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Metro police arrested a man early Monday morning for his fourth DUI.Jeremy Church, 31, was pulled over on Elliston Place after an officer spotted him driving down the center turn lane without making a turn.The officer stated he noticed a strong odor of alcohol coming from inside the car and Church's speech was slow and slurred.Church later refused to get out of the car and asked if he could sleep in the backseat instead. According to the police report, Church finally got out of the car but refused to cooperate and argued the officer was not the original police officer who stopped him.Arrest records show Monday is the fourth time Church has been stopped on suspicion of DUI in Davidson County. His most recent arrest was in late October.Church was not involved in any crashes at the time of his DUI arrests.Phaedra Olsen with Mothers Against Drunk Driving told Nashville's News 2 tougher DUI laws are needed in Tennessee. "Tennessee needs to have a primary ignition interlock program. By being able to have that we can keep those drivers from driving as repeat offenders," said Olsen.Olsen knows firsthand what can happen at the hands of a drunk driver. She was hit by one in 1996, a crash that nearly killed her and left her confined to a wheelchair. "It's frustrating. It's frustrating because in today's society everyone knows drinking and driving is against the law and in a situation like this there are so many options," said Olsen.Church made bond and was released from jail Monday morning. He is due in court January 9.
The following are mugshots of individuals arrested in May by local authorities in Northeast Tennessee.
441 Murfreesboro Road Nashville, TN 37210
Telephone: 615.369.7222
Fax: 615.369.7329
Email: email@example.com


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Nintendo has announced it plans to release new games hardware, with the intention of helping the company expand into new and developing territories »
What if a hardware manufacturer built a gaming machine that functioned with all the ease-of-use of a console, but could accept modular upgrades like Ara? »
China has announced it is drafting rules to accompany the lifting of its 14-year ban on gaming consoles »
Ouya, the Android-based games console, will now be accepting Bitcoin for payments »
Sony has released the PlayStation 4 1.51 firmware update ahead of the console's 29 November launch in the UK »
The Xbox One has sold more than one million consoles in its first 24 hours, according to information released by Microsoft »
Many game consoles aspire to be more than just a game console, but Xbox One really means it. Xbox One wants to be your everything and run your TV, your Blu-rays, your streaming, your music and, oh, sure, your videogames too »
Just ahead of the Xbox One's launch, Activision has announced that Call of Duty: Ghosts is already dominating the next-gen game space »
Microsoft has confirmed that the Xbox One will launch with a dedicated YouTube app in the UK and other markets »
Sony has issued a statement acknowledging that there are several issues being reported with PlayStation 4 consoles but pegs the number of affected units at less than one percent »
The PlayStation 4 has sold more than a million units in the first 24 hours of its release in North America »
As part of an earnings call, Ubisoft's CEO put PlayStation 4 pre-orders ahead of those for the Xbox One, although was keen to stress affection for both consoles »
Production of Nintendo's original Wii console has been officially discontinued »
An Ofcom report reveals that games console ownership in UK households has declined for the second year in a row »
The UK could face up to four months of PS4 shortages after the console launches on 29 November after the company underestimated consumer demand »
Microsoft's Xbox One will launch in the UK on 22 November, 2013 »
Nintendo's most recent quarterly financial report paints a rather bleak picture of the Wii U with the console not even managing to outsell the nearly seven-year-old Wii »
After the traditional flutter of anxiety, frustration and resignation which greets the pricing announcements of new console generations (hello, £429 Xbox One and £349 PS4), much airtime is being given to more affordable alternatives like GameStick »
Google is working on a videogame console based on its Android operating system, according to a report in the Wall Street Journal »
Nintendo reports that the Wii U console has missed its sales target by around half a million units »
In what is best described as a flash memory willy-waving demo, Kingston has unveiled a 1TB USB thumbdrive -- that's over a thousand gigabytes on your keyring »
The new working environment is at once rec room and high street, coffee bar and potting shed »
Wired.co.uk reviews the Vodafone Smart 4 Turbo »

subset: commoncrawl


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i've been reading a lot about self-signed certificates and a lot of people seem to know a lot about them and i was wondering if anyone can help me. i have a nokia n73 which runs s60 3rd edition, and when i created my theme .sis file and transfer to my phone, it says certificate may not be valid, expired,or phone clock settings incorrect.
the 2 solutions i've already read about on this forum is to use the cygwin program to create the key and cer file and the other to syncronise phone time and computer time
i've downloaded cygwin and created the .key and .cer file from that and it still doesn't work. i've also made my phone's time settings the same, earlier, and later than my computer's clock time.
i would really like to create my own themes!
i would really appreciate the help!


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|Drone outcries a double standard
By Cal Thomas
AN UNSIGNED and undated Justice Department white paper, obtained by NBC News, reports The New York Times, ". . . is the most detailed analysis yet to come into public view regarding the Obama legal team's views about the lawfulness of killing, without a trial, an American citizen who executive branch officials decide is an operational leader of Al Qaeda or one of its allies."
The proviso is they must pose "an imminent threat
|Tuesday, February 12, 2013 4:29 PM
|Last Updated on Wednesday, February 13, 2013 1:57 PM


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|SitePoint Sponsor
User Tag List
Results 1 to 2 of 2
Thread: Please help in htaccess !
Jul 24, 2011, 18:38 #1
- Join Date
- Jul 2011
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Please help in htaccess !
Hello ,
I have programmed an small script for my members
script job is
1- They can create them folder on my site
2- They can create unlimted html pages in them folder on my site !
i have configured wildcard on server and it's ok
every thing is okay
i need only htaccess file
i want htaccess do that
1 - rewrite [VALUE1].mysite.com ----- mysite.com/folder.php?foldername=[VALUE1]Code:
2 - rewrite [VALUE1].mysite.com/[VALUE2] ---- mysite.com/folder.php?foldername=[VALUE1]&[VALUE2]
[VALUE2] is [page=about_me&paged=2]
Please Help
i finnaly finished my script after 4 months work !
and really need your help !
some one asked this question before
here the post
and they answered him right
but he required only one value [ profile.php?username=[NAME]
i required two values [folder.php?foldername=[VALUE 1]&[VALUE 2]
Jul 29, 2011, 02:27 #2
- Join Date
- Feb 2002
- Location
- Auckland
- Posts
- 14,680
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You are trying to capture the username from the subdomain and a filename, too. No problem.
IMHO, you should NOT attempt to redirect to the main domain but the subdomain should be pointed at the main domain (SHARED DocumentRoot) and allow mod_rewrite to fetch the subdomain's folder (because it makes your redirections easier when the URL does not change).
1 - rewrite [VALUE1].mysite.com ----- mysite.com/folder.php?foldername=[VALUE1]Code:
RewriteEngine on RewriteCond %{HTTP_HOST} !^www\.mysite\.com$ RewriteCond %{HTTP_HOST} ^([a-z]+)\.mysite\.com [NC] # NOTA BENE: The subdomain and folder must be lowercase! RewriteRule ^$ folder.php?foldername=%1 [L]Code:
2 - rewrite [VALUE1].mysite.com/[VALUE2] ---- mysite.com/folder.php?foldername=[VALUE1]&[VALUE2]Code:
RewriteCond %{HTTP_HOST} !^www\.mysite\.com$ RewriteCond %{HTTP_HOST} ^([a-z]+)\.mysite\.com [NC] # again, the subdomain and folder must be lowercase! RewriteRule ^([a-z./]+)$ folder.php?foldername=%2&link=$1 [L] # I added a key name of "link" for $1 to enable it to be accessed properly # the path/filename must be lowercase letters only (with / and . as appropriate)
DKDavid K. Lynn - Data Koncepts is a long-time WebHostingBuzz (US/UK)
Client and (unpaid) WHB Ambassador
mod_rewrite Tutorial Article (setup, config, test & write
mod_rewrite regex w/sample code) and Code Generator


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Alex Brightman, Andrew Kober and F. Michael Haynie Will Join Composer Drew Gasparini at 54 Below
By Andrew Gans
Award-winning composer Drew Gasparini will make his 54 Below debut in December.
The Dec. 13 concert will feature songs from the composer's musicals Make Me Bad; #UntitledPopMusical; Crazy, Just Like Me; and Inappropriate Stories Told At A Bar as well as songs from his album "I Could Use A Drink." Show time is 11 PM.
Gasparini will be joined by The Morontourage (Broadway's Alex Brightman, Andrew Kober and F. Michael Haynie) as well as his sisters, Kasie and Chloe Gasparini. Doors open at 10 PM.
Drew Gasparini won the John Lennon Songwriting Award, and his music has been heard on NBC's "Smash" and in venues all over the country, including the Kennedy Center. His musical Make Me Bad (book by Alex Brightman) won PACE new Musicals, his musical Crazy, Just Like Me won Best of Fest at NYMF 2011, and his musical adaptation of Turn Of The Screw (book by Michael Kimmel) was presented at Lincoln Center in 2012.
There is a $25-$35 cover charge and a $25 food and beverage minimum. 54 Below is located at 254 W. 54th Street. Tickets and additional information are available at 54Below.com.
Send questions and comments to the Webmaster
Copyright © 2014 Playbill, Inc. All Rights Reserved.


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Trials & Litigation
Priceline doesn't have to tell customers it pockets profits, appeals court rules
Posted Mar 27, 2013 2:00 PM CDT
By Molly McDonough
The New York-based 2nd U.S. Circuit Court of appeals ruled Wednesday that Priceline.com doesn't have a fiduciary duty to tell its customers when it pockets profits from bookings through its "Name Your Own Price" service.
Plaintiffs Lee Johnson and Joey Marie Kelly sued Priceline, alleging the online travel agency was breaching its fiduciary duty to customers by failing to disclose that bids for hotel rooms often exceeded the amount Priceline compensates hotel vendors, Reuters reports.
But the unanimous three-judge panel sided with Priceline, holding that while the company is obligated to provide accommodations at the stated sum, customers have no authority over how the reservation is negotiated. The court likened the company to "an intermediary or middleman rifling through its inventory of discounted hotel rooms until it locates an item for which the customer has stated a willingness to pay a specified price."
The court further held that, "The fact that only Priceline has access to both its algorithm and its particular inventory of discounted hotel rooms does not create a fiduciary relationship with a customer where none otherwise exists."
Reuters notes that the decision affirms a decision by U.S. District Judge Bond Arterton, of the District of Connecticut, to dismiss the suit.
Add a Comment
We welcome your comments, but please adhere to our comment policy. Flag comment for moderator.


text:
Professional Sections
The EAIE has 10 different Professional Sections (PSs) providing specialised expertise in key areas of international education for EAIE members.
For all those involved in credential evaluation, student mobility and recognition of periods of study abroad.
For administrators, advisers, educators and scholars in the field of Economics and Business Studies.
For professionals involved in all aspects of educational cooperation with developing countries, ranging from policy development and information dissemination to liaison work, project development, implementation and management, and student advising.
For professionals involved in employability skills, international internships and graduate careers.
For those with overall managerial responsibilities or those who work with institutional policies at an institutional or departmental level, or managers at national/international organisations within the field of international education.
For professionals working with diverse cultures and languages in educational institutions, business, human services, governmental and non-governmental agencies.
For all those involved in all aspects of European programmes from policy development and information dissemination to liaison work, European project development and management as well as student advice.
For those who develop, or wish to develop, international marketing and recruitment responsibilities within higher education institutions, or have international marketing responsibilities at a national or international level.
For professionals in the field of guidance and counselling for domestic and international students.
For all those involved in providing services and guidance to foreign students and scholars, advising students about study abroad opportunities or promoting study abroad programmes in their institutions.
Become a member and log in to the Member Centre to choose your Professional Sections.
Become a member and log in to the Member Centre to choose your Professional Sections.


text:
Inspired by the dresses of Flamenco dancers the ruffles on these show stopping sandals gently curve around the ankle. Heel measures 120mm/4.7
US Standard FREE
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See full delivery and returns information.
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Jimmy Choo shoes are in Italian sizing


text:
After a pair of early picks, Jay Cutler settled in for the Chicago Bears as they beat the Cleveland Browns, 38-31, in Cutler's return from injury on Sunday.
Bears coach Mark Trestman made the controversial decision to start Cutler instead of Josh McCown, who led Chicago to three wins while filling in for an injured Cutler during the last month and a half. That decision looked as though it would backfire early after two early picks put the Bears in 10-3 hole, but Cutler bounced back to finish with 265 yards and three touchdowns.
Cutler's day got off to a bad start when he threw a redzone interception on his first possession of the game. On just his fourth attempt, he attempted to fit a pass into double coverage and had it tipped and intercepted in the endzone by Tashaun Gipson.
Gipson picked off Cutler a second time midway through the second quarter, this time finding the endzone for a 44-yard pick-six to put the Browns up 10-3.
The Bears would return the favor with an almost identical play early in the third quarter when Zack Bowman picked off Jason Campbell and raced 43 yards down the sideline to give the Bears a 17-10 lead.
The Browns then answered with a 14-0 run. Edwin Baker found the endzone on a two-yard rush, then T.J. Ward picked up a Chicago fumble and raced 51 yards for a defensive touchdown to put Cleveland up, 24-17.
Cutler really began to hit his stride in the fourth quarter, leading the Bears to touchdowns on three consecutive drives to pull away late. The comeback began when Alshon Jeffery climbed the ladder to haul in a 45-yard pass early in the quarter to tie the game at 24.
Cutler then found Earl Bennett on a four-yard score to take the lead. Michael Bush put the game way with a 40-yard run to take a two touchdown lead with just over three minutes remaining.
The Browns pulled back to within seven with just over a minute left when Josh Gordon busted loose for a 43-yard touchdown.
Fantasy studs and duds
Cutler's strong play led to big days for two of his receivers. Brandon Marshall had six grabs for 95 yards and touchdown while Jeffery caught five passes for 72 yards and a touchdown. Matt Forte rushed 24 times for 127 yards, but failed to find the endzone.
An otherwise quiet day from Gordon was salvaged on a late 43-yard touchdown. He finished with just three receptions for 67 yards.
Did they cover?
The Bears covered the spread after opening as 1.5-point favorites, according to Oddsshark.com.
What's next?
Cleveland Browns travel to the New York Jets at 1 p.m. ET next Sunday, and the Bears travel to Philadelphia for an 8:30 p.m. ET game with the Eagles.
More from SB Nation NFL
• NFL Week 15 updates, highlights and GIFs | Live Scores
• Count out Touchdown Tom, Fins beat Pats
• GIFs: Steven Jackson bulldozes for a TD | Alshon Jeffery's crazy TD
• Vernon Davis scores, runs into wall | Victor Cruz out with concussion
• Breaking Madden: Tony Gonzalez, cranky old man of destruction


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Zelda Stein Weiss Cancer Center of Mon General Hospital dedicated
Posted Date: 9/28/2011
Zelda Stein Weiss has dedicated more than half a century of volunteer service and philanthropy to Mon General Hospital. On Thursday, Sept.15, 2011 her commitment was celebrated with the naming of the hospital's new Zelda Stein Weiss Cancer Center of Mon General Hospital in her honor.
Zelda passed away February 15, 2012 at the age of 95. Her unique spirit will be missed throughout Mon General and the entire community.
"Zelda's high standards and her commitment to this Health System have been second to none," Mon Health System President and CEO Darryl Duncan told the 150 friends, community leaders and hospital staff gathered in the hospital's main lobby for the center's official dedication.
Weiss involvement in cancer care at Mon General dates back to 1990 when the Zelda Stein Weiss Cancer Awareness and Early Detection Project of Mon General Hospital was launched. This program has been providing low cost cancer screenings and cancer information to the residents of Morgantown and the surrounding region.
In addition, thanks to the Zelda Stein Weiss Cancer Awareness and Early Detection project, the hospital recently opened two computer kiosks just off the main lobby for patient and visitor use. The kiosks are designed to allow users to look up health information on the internet. Each station consists of a computer, printer and telephone. In addition, the kiosks contain printed cancer information and cancer screening materials.
Weiss has been a member of The Foundation of Mon General Hospital Board of Directors since its inception in 1976. She is also an original member of the Mon General Hospital Auxiliary, formed in 1944.
"Zelda had a vision that we could do comprehensive cancer care right here at Mon General Hospital," Duncan said. "That's our goal. That's where we are heading. We've taken a few giant leaps with the addition of Dr. Larry Beall and Dr. Darryl Saunders to the hospital staff this fall and putting their offices right next to the Infusion Center.
"The vision continues. We are going to have comprehensive cancer care here at Mon General Hospital. And you're the one that started it," he told Weiss. "It's very appropriate that your name go on the cancer center."
Duncan's comments were echoed by board members and physicians.
"We are honoring one the most dedicated, driven, and beautifully put together women that I have ever met in my entire life," said Mon Health System Board Chairman Glenn Adrian.
Adrian first met Zelda 22 years ago when he was a new member of The Foundation of Mon General Board. "As a new board member, she wanted to make sure she took the time to introduce herself," he said. "But, also to remind us as Board members we were there to do a job. 'You're going to help us, you're going to contribute and we're going to make this hospital better.' She didn't say that, but you could see it. Those eyes, warm as they are, they have steely blue in them. It was from that moment on that I understood the great commitment that Zelda has for this hospital.
"Bricks and mortar are great," he said. "But a community hospital is all about people. I would say to you today that if we opened up the bricks and mortar of Mon General Hospital, on its heart would be emblazoned the name of Zelda Stein Weiss. That's the kind of commitment that must continue."
"Zelda Stein Weiss is a name that when you mention it to anyone who has known her, it evokes a warm feeling," said Mon General Board of Directors Chairman Sarah Minear, thanking her for helping to make Mon General the finest hospital in the region. "The powerful combination of Zelda's keen intellect and her deep compassion to help others is an inspiration to anyone who has met her."
"From the first time we met, I knew that I was in the presence of an extraordinary woman; a lady with tremendous self-confidence, poise, warmth, wisdom and intellect," said Mon General Hospital Foundation Board Chairman Steve LaCagnin in comments read at the dedication. "I know that I speak for The Foundation Board and the hospital when I say we have been blessed to have her as a volunteer, benefactor, critic, supporter, and friend. It can truly be said that Zelda has been instrumental with our hospital achieving excellence, and by virtue of that, Zelda has made our community a better place in which to live and raise our families.
Oncologist Charles L. Beall, MD, said Weiss was the definition of philanthropy and thanked her for her generosity.
To officially name the cancer center, Duncan and Zelda's son, Ken Weiss, unveiled a mockup of the new "Zelda Stein Weiss Cancer Center of Mon General Hosiptal" sign. The new name can also be seen at the East Canopy elevator.
Also during the Zelda Stein Weiss Cancer Center dedication, the hospital celebrated the grand opening of its new Infusion Center. Tours were offered during the three hour program.
Mon General Hosiptal's new Infusion Center is located on the 3rd Floor of the hospital's North Tower. The Infusion Center is part of the Zelda Stein Weiss Cancer Center and is where many Mon General oncology patients receive treatment on an outpatient basis.
"This is a new day for cancer care at Mon General Hospital," said Oncologist Darrell Saunders, MD, thanking Weiss for her support. "With the building of the new Infusion Center and soon to be doctors' offices, we will be able for the first time to have cancer care under one roof which will make it a lot easier for our patients."
Infusion Therapy includes the administration of intravenous (IV) medication, intravenous fluid and/or blood products as ordered by the patient's physician.
The Infusion Center was relocated from the 1st Floor of the hospital's South Tower to make room for a new Orthopedic Center. The Infusion Center features eight treatment rooms. Six of the rooms are private and two are semi-private. The new center also includes a dictation room for physicians and a private consultation room.
"This is a positive move for the Infusion Center," said Ellison Ponzurick, Director of Mon General Hospital's Oncology Service Line. "The move will place the center adjacent to the Oncology physician offices and will bring it closer to clinical services."
"The new Oncology Center is light, airy, quiet and calming," Ponzurick said. "Every room has a window, so there is a lot of natural light. Special ceiling tiles were used to reduce noise."
Cancer Care
Cancer Health Library
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text:
Printing to certain lab printers through the UB wireless network on a MAC running OSX 10.7 is different than prior version of OSX. Follow these instructions to add the printer and release it from the IPRINT server. To use wireless printing, you need:
The following printers are available to students:
To print wirelessly from OS 10.7.x, you will need to first add the lab printer you want to use, then each time you send a document to the printer, you need to release it for printing.
Add the Printer to your Computer
Note: You might have to download the correct print drivers. Go to http://support.apple.com/kb/DL907 , download, and install HP Printer Drivers.
That printer is now available for you to select as a printer.
Release the Document for Printing
The next step is to review and release the document from the print server. You will have 30 minutes to release the document before it is automatically deleted.
Note: You have to access https://iprint.ubalt.edu/pcounterwebclient from the same Mac that you printed from to be able to release the document. Documents not released within 30 minutes are automatically deleted.


text:
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text:
Book Reviews
Literature Features:
Readers & Writers Our monthly conversation on contemporary literature
North Country Reads A one book, one community project for the North Country
Recent Books Recent regional books received at NCPR
Recommended by listeners and staff The 2008-09 Winter Reading List
Book Reviews
Jun 19, 2014 — Maria Venegas' emotionally raw, technically complex new memoir chronicles her troubled relationship with her father, a man whose life was dominated — and eventually ended — by violence.
May 22, 2014 — The Essential Ellen Willis focuses on the writer's explicitly feminist culture criticism. It was edited by Willis' daughter, who published an earlier collection of her mother's essays in 2011.
May 21, 2014 — Francine Prose's latest novel was inspired by a 1932 photo of two lesbians, one of whom was in the Gestapo. Critic Maureen Corrigan says it's an ingenious excursion into the Parisian demimonde.
May 5, 2014 — Biographer Amanda Vaill's new book delves deeply into the lives of journalists like Ernest Hemingway and Martha Gellhorn, whose documenting of the war helped shape public perception.
Apr 6, 2014 — Years after she first read and adored Ellen Emerson White's series of young adult novels, author Tova Mirvis still finds herself wondering, "What would Meg Powers do?"
« first « previous 10 76-85 of 92 next 7 » last »


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Dallas Cowboys wide receiver Dez Bryant has left the team's practice on Monday with an apparent knee injury, according to reporter Clarence Hill. The 6-foor-2, 220 pound wide receiver was seen with trainers examining his knee, officials told Hill.
Bryant caught two passes for 15 yards in Saturday's 28-20 preseason loss to the San Diego Chargers.
Before the Cowboys' first preseason game against the Oakland Raiders, Bryant was banged up with a hamstring injury that kept him out of practice and only participating in walkthroughs. Two days after suffering the hamstring injury, he caught one pass for 24 yards and only played in one possession.
In three years in the NFL, the Oklahoma State product has pulled in 108 passes for 1,489 yards for the Cowboys. Last season was by far his best, as he nearly reached the 1,000 mark with 928 yards.
Check out Blogging the Boys for more on the Dallas Cowboys, or hit up SB Nation's NFL hub.


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If you don'Äôt count your blessings every day, you will after listening to Jonathan Kozol'Äôs Fire in the Ashes, read by Keythe Farley; and if you'Äôre not affected by these true stories from the sordid, shameful inner city, better check for a pulse. For many decades and in many books, Kozol has given a voice to the voiceless: children who grow up in punishing poverty and their parents. He'Äôs not an observer, but part of the fabric of their lives. Here, he tells the stories of young men and women who spent their very early years in the notorious Hotel Martinique, a hellish, filthy, drug-infested homeless shelter right across from Macy'Äôs on New York'Äôs Herald Square, and were later moved to the poorest section of the Bronx. They'Äôre grown now'ÄĒthe ones who survived'ÄĒsome terminally damaged, while some, with the aid of a few truly good people, including Kozol and a determined parent, found their way out, and found the spark that lights the fire. Listen'ÄĒthere'Äôs much to be learned.
The Beautiful Mystery, Louise Penny'Äôs latest, brings Chief Inspector Armand Gamache and his close comrade Inspector Jean-Guy Beauvoir to Saint-Gilbert-Entre-les-Loups, a remote monastery deep in the Quebec wilderness, to investigate the murder of the choirmaster. Long hidden from the world, these cloistered monks have lived in quiet self-sufficiency, praising God in simple, glorious Gregorian chant for centuries. But now a recording made to raise much-needed money has become a global sensation'ÄĒand one of the monks has become a murderer. Gamache and Beauvoir find deep discord beneath the harmonious surface of the abbey and, in its devout solemnity, find themselves face to face with their own doubts, demons and insecurities. This is much more than a whodunit; Penny renders her characters with real depth and puts them in an unusually intriguing setting and situation. And Ralph Cosham'Äôs excellent, empathetic narration enhances it all.
Where'Äôd You Go, Bernadette is an epistolary novel, without epistles'ÄĒat least, not the conventional kind. Instead, author Maria Semple weaves together emails, school report cards, police reports, FBI files, an emergency room bill, a psychiatrist'Äôs notes, a fundraising letter and more. The only narrative is offered by 15-year-old Bee, one of the most charming teenagers I'Äôve met in ages. And Bee is not the only charmer. Bernadette'ÄĒwho, as you know from the title, does a disappearing act'ÄĒis a fabulous creation: an architect who only built one house, won a Mac¬≠Arthur 'Äúgenius'ÄĚ grant, then gave it all up in a grand snit; an agoraphobic, Seattle-hating Seattleite who can quip with the best; and Bee'Äôs mother, who cherishes her brilliant daughter. The other characters are drawn with the same wit, the subplots unleashed with an accurate, antic take on our world. Kathleen Wilhoite'Äôs reading, lit by a range of voices, accents, cadences and emotions, is a true treat.


text:
Please join us for the The Italian American Law Students Association Annual Alumni DinnerWednesday, April 14th6:30 — 9:00 pmForchelli Conference Center, Feil Hall205 State Street, Brooklyn, NY The Italian American Law Students Association will be celebrating a successful 2009-2010 year. The organization will honor Judge Eric N. Vitaliano for his contributions to Brooklyn Law School and his exemplary career as an Italian-American jurist. Ms. Evelyn Lawrence '42 will also be honored for her distinguished career as an attorney in Brooklyn and her contributions to the Italian-American legal community. She will provide a brief discussion on her time at Brooklyn Law School during World War II.
RSVP to: email@example.com Space is limited. For questions please contact: firstname.lastname@example.com
View video of the recent Symposium: Choice of Law in Cross-Border Bankruptcy Cases
"Brooklaw," the BLS Seal, and Logo are service marks of Brooklyn Law School. Contents Copyright © 1995-2013 Brooklyn Law School. All rights reserved.


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Find Your Next Interior Designer!
Search below to find Interior Designers near you
Are You a designer?
1. Register your design company
2. Select the locations you serve
3. Connect with more Clients
How It Works:
1. Search your area
2. Browse local designers
3. Read reviews & contact who you like


text:
Travis Watley, charged in the murder at the Henderson American Legion, has been released on a $150,000 bond this morning from the Rusk County Jail.
bond was assigned by Justice of the Peace Precinct 5 Judge Joe Sorrells.
According to the Henderson Police Department, At approximately 12:20
a.m. on Sunday, the Henderson Police Department received a call of
multiple shots being fired at the American Legion located at 601 Sand
St. in Henderson, Texas. Officers were informed there was at least one
person, inside the building, that had sustained multiple gunshot wounds
to his upper body.
The victim was identified as 53-year-old Roy Lee Moore of Henderson.
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text:
A bizarre mountain retreat built on top of a 26-floor Beijing residential building faces demolition after complaints by residents.
The rooftop structure is covered by fake rocks, trees and bushes, and can be clearly seen from one of Beijing's busiest commuter roads in one of the city's more upmarket areas.
Locals say the unusual high-rise retreat has been slowly taking over the rooftop for years -- construction is said to have started in 2007 -- but is only now receiving attention after images of the unlikely extension went viral on social media.
The owner of the rocky outcrop has been identified as Professor Zhang Biqing, a doctor of traditional Chinese medicine who owns a national chain of acupuncture clinics, and is a former member of a district People's Political Consultative Conference (CPPCC), according to the South China Morning Post.
Some residents claim the retreat has caused cracks in their walls, which leak when it rains.
Zhang is reported to have said he would demolish the villa if requested.


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FreeNAS™ is an embedded open source network attached storage (NAS) system based on FreeBSD and released under a BSD license. A NAS provides an operating system that has been optimized for file storage and sharing.
The FreeNAS™ Project was originally founded by Olivier Cochard-Labbé in 2005 and was based on m0n0wall, an embedded firewall based on FreeBSD. It was PHP based, easy-to-use, and had lots of features. In December of 2009, Olivier announced that the .7 branch would be placed in maintenance-only mode as he no longer had time to devote to further FreeNAS™ development. Volker Theile, a FreeNAS™ developer who also develops on Debian in his day job, decided to start the OpenMediaVault project, which would be a rewrite of FreeNAS™ based on Debian Linux and released under the terms of the GpLv3 license. Many FreeNAS™ users were not pleased about the change of license and the loss of kernel-based ZFS support due to GPL incompatibilities with the CDDL license.
iXsystems, a provider of FreeBSD-based hardware solutions and professional support, took the initiative to continue the development of a BSD licensed FreeNAS™ solution based on FreeBSD. They took the opportunity to analyze the positives (lots of cool features) and negatives (monolithic, everything-but-the-kitchen-sink design that was difficult to maintain and support). It was decided that the next version would be rewritten from scratch using a modular design that would provide a basic core NAS with a plugin architecture for adding non-core features. This would allow FreeNAS™ to have a small footprint that was easy to support while allowing users to just install the plugins for the features they desired. It would have the added benefit of allowing users to create and contribute plugins for niche features, allowing usage cases to grow according to users' needs.
Work on the new design began in 2010 when the 8.x branch was created to differentiate the new design from the original design. Table 1a lists the 8.x releases and provides links to the release notes for each released version:
Table 1a: FreeNAS™ 8.x Releases
|Release Date
|Release Notes
|May 2, 2011
|September 30, 2011
|October 13, 2011
|January 3, 2012
|February 29, 2012
|expected May, 2012
|expected Q2 2012 and will be based on FreeBSD 8.3
Except for the upcoming 8.3 release, each release in the 8.x branch is based on FreeBSD 8.2. Once the 8.x branch has reached the end of its development cycle, the 9.x branch will be created. This is expected to occur when FreeBSD 9.1 is released, in late 2012.


text:
Your Source For Tracy and Mountain House California Real Estate
Tracy California
You can find a great selection of Tracy CA Homes and Tracy Real Estate here at our website. Also, Between 1990 and 2007, the population of Tracy more than doubled as people found the hometown feeling and a more relaxed way of life. Locals call Tracy one of the friendliest cities in California.
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Tri Delta Transit offers Mountain House residents convenient commuter bus service to the Dublin/Pleasanton BART station. In addition Mountain House is served by, San Joaquin Regional Transit District (SJRTD) at the ParkNRide by the West Valley Mall in Tracy, and the Altamont Commuter Express (ACE) station, which provides commuter rail service to the San Francisco Bay Area.


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our locations
Midtown1345 Ave. of Americas
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New York, 10105 Read More
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As the premier provider of New York City temporary, virtual and co-working offices in six Midtown locations with over 200,000 square feet of shared office space, you'll have your pick of the best commercial real estate properties in NYC. In fact, our business tenants gain limitless opportunities for leasing office space in some of Manhattan's most prominent business buildings.
Whether you need a completely furnished executive office suite for an individual or something larger to accommodate a growing company, we have just the plans you need for turnkey, short-term shared office spaces.
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Need a prime location in New York City without the expense of a physical office location? Our virtual office solutions are perfect for those businesses desiring the prestige of a Manhattan NY location without the expense. We provide you with a business address, mailbox and company listing as well as mail handling and distribution. NYC phone numbers are also available. Read More ….
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Virgo conference and meeting quarters are available at all our leasing locations in Manhattan. Each facility provides conferencing space for 5 to 20 people. Rooms come fully equipped with flat screens, whiteboards, speakerphones, handsets and voice conferencing. Our meeting and conference facilities also offer access to secure, high speed internet and cable TV. Our office rental properties and conference session rooms rent by the hour or by the day. Read More ….


text:
I am loading a DLL dynamically using Rlibrary::Load() API in a console application. DLL gets loaded without error.
I got the pointer of the NewL() present in DLL using RLibrary::LookUp().
But When I call that function, application is exiting with error " Exit type 2,3, KERN-EXEC".
PLease provide any work around for this probelm.
DLL has ALL capability, application has Local Services capability
Code is as follows:
RLibrary lib;
RBusDevComm idevcom; //dummy
CSTLC2500 *icstlc2500;
if (!lib.Load(STBtDriver))
console->Printf(_L("STLC2500 loaded"));
console->Printf(_L("STLC2500 not loaded"));
TLibraryFunction entry=lib.Lookup(4);
typedef CSTLC2500* (*Tstlc2500newl) (RBusDevComm&);
Tstlc2500newl newl = reinterpret_cast<Tstlc2500newl>(entry);
icstlc2500 = newl(idevcom);
console->Printf(_L("Newl returned"));
Thanks in Advance


text:
Updated May 7, 2013 - 4:59 pm
Northbound SR 51 reopened after truck rollover
By Martha Maurer
Originally published: May 7, 2013 - 3:35 pm
Originally published: May 7, 2013 - 3:35 pm
A cement truck rollover closed northbound State Route 51 for more than three hours on Tuesday.
Northbound traffic was forced off the highway at Cactus.
The Arizona Department of Safety said the truck blew a tire and the driver lost control, hitting two vehicles and then striking the median wall, removing a large chunk. The truck was full of cement at the time.
Debris from the crash also blocked two lanes of southbound SR 51. Those lanes were reopened about 2:50 p.m. The northbound lanes were reopened about 3:30 p.m.
Minor injuries were reported.
Martha Maurer, News Editor
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If there is one thing both Spring-Ford and Pennridge learned in last weekÆs District 1-Class AAAA quarterfinals, it was how no lead is a safe lead ģ and how to, well, hang on.
Spring-Ford had a 28-0 halftime lead, then withstood a Ridley air attack for a 28-26 win Ś which wasnÆt secured until Zameer McDowell dropped RidleyÆs quarterback one yard short of the end zone on a two-point conversion attempt with 2:46 remaining. Pennridge had a 28-7 lead late in the third quarter, then withstood a very impressive Pennsbury rally for a 28-27 win ¢ not secured until PennsburyÆs final point-after attempt hit the upright with 1:47 remaining.
Eerie similarities, for sure.
Big leads.
Big leads nearly blown.
A two-point win, a one-point win.
And both teams are coming off their traditional Thanksgiving games Ś Spring-Ford against Phoenixville (played Wednesday night), and Pennridge against Quakertown (played Thursday morning).
On top of all that, theyÆre both the Rams.
So, dare we say it? Sure, why not.
This afternoonÆs district semifinal could be (and probably will be) a ōBattle of the Battering Rams.ö
But the similarities donÆt necessarily end with what happened last week.
Spring-Ford has a couple of backs, namely Jarred Jones and Yousef Lundi, who love to run anywhere their line leads them. Pennridge has one particular back, Mike Class, who loves to run anywhere his line leads him.
All three scat, scoot and sprint rather well, too.
Jones, who missed six midseason games but has been back for the last three, has 838 yards and an area-high 8.8 yards per pop average. Lundi, who was the workhorse in JonesÆ absence but has since returned to his normal fullback spot, has 959 yards and a team-high 14 touchdowns. Class, meanwhile, is absolutely in a class of his own, bettering the combined Jones-Lundi numbers with 2,359 yards, an 8.6-yard per carry average, and 31 touchdowns ¢ and thatÆs despite not carrying the ball one single time Thursday against Quakertown when he sat out with a reported concussion.
Spring-Ford has a very good quarterback in Hank Coyne, as does Pennridge in Alex Krivda.
Both throw the football very well, and quite accurately.
Coyne has completed 54.1 percent of his attempts for 1,687 yards and 22 touchdowns, and has three very good receivers in Tate Carter, Gary Hopkins and R.J. Sheldon. Krivda has completed 53.6 percent of his attempts for 1,076 yards and 13 touchdowns, and has two very good receivers in Kyle Bigham and Micah Stutzman.
Add all of those numbers up, along with their respective unsung teammatesÆ contributions, and you get Spring-Ford Ś without the non-varsity starterÆs production Wednesday night Ś averaging 356 yards and 36.8 points a game, and Pennridge averaging 391 yards and 33.2 points a game (after capturing the Suburban One Continental Conference championship with the 28-13 win Thursday morning at Quakertown).
ōIÆve seen both (teams),ö a Suburban One Conference assistant coach said off the record earlier this week. ōThey are very similar on offense. Spring-Ford may be a little more balanced with the run and pass, but Pennridge has Class, heÆs a game-changer, and Krivda is a darn good quarterback, too.ö
So what gives, or what will give?
Well, no postseason game, in any sport when you come to think of it, is ever won without defense.
Needless to say, the teamsÆ similarities run the gamut on the other side of the ball, too.
Spring-Ford has some size up front, gets to the football pretty well, and had limited opponents to 17 points a game prior to the Phoenixville mismatch. Pennridge has some size up front, gets to the football pretty well, and has limited opponents to 19.3 points a game.
Sure looks like an even-up, or quite intriguing, game Ś according to the math, or at least on paper.
So, dare we say it one more time? Sureģ
ōA Battle of the Battering Rams.ö
Don Seeley is the sports editor of The Mercury. He can be reached at email@example.com


text:
I am developing an app with QML on N9. And I wanna play some sound effects and background music. So I use QML components SoundEffect and Audio. It works normally running on simulator, but fails on N9 device. I have add mobility into my pro file as follows:
I got some information from compile output:Code:CONFIG += qdeclarative-boostable mobility MOBILITY += multimedia
aegis-installing wordmatch (from '')
Package wordmatch: denied 'GRP::audio' -- origin '' does not allow it
Package wordmatch: denied 'GRP::audio' for '/opt/WordMatch/bin/WordMatch' -- origin '' does not allow it
Package wordmatch: denied 'GRP::audio' for 'applauncherd-launcher::/usr/bin/applauncherd.bin' -- origin '' does not allow it
But i can't figure it out.
Did anybody come up against this problem? Plz help me, Thanks~
Ps: The source of SoundEffect & Audio is from local audio files, like mp3.


text:
ph: my own
Hey boos- I've added more goodies for sale over on my Copious store!
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Check it all out HERE. Happy shopping + selling!
ps- Check out two of my favs Man Repeller + because im addicted on Copious as well!
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text:
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Identifying aortic valve regurgitation early is important because the condition can worsen with time, and you may need surgery to correct it.
Your doctor may first suspect that you have aortic valve regurgitation during a routine office visit after listening to your heart with a stethoscope and hearing an abnormal heart sound (heart murmur). Blood leaking through the aortic valve often makes a distinct sound.
To begin the evaluation of your heart, your doctor will ask you questions about your personal and family health history. Next your doctor will perform a physical examination that concentrates on your heart.
From this information, your doctor decides what tests you may need in order to make a diagnosis and develop a treatment plan. For testing, you may be referred to a cardiologist — a doctor who specializes in the study of the heart and its function.
Other heart problems can cause signs and symptoms similar to those of aortic valve regurgitation, and it's possible to have more than one disorder at the same time. Common tests doctors use to diagnose aortic valve regurgitation include:
These tests help your doctors diagnose aortic valve regurgitation, determine how serious the problem is, and decide whether your aortic valve needs repair or replacement.
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text:
FOX 8 received this news release from the Louisiana Workforce Commission Thursday evening:
Not seasonally adjusted nonfarm employment grew in Louisiana in May to 1,956,800, with the private sector growing by 1.6 percent over the year, the federal Bureau of Labor Statistics reported today.
Not seasonally adjusted total nonfarm employment increased by 19,400 over the year and 4,500 over the month.
Private sector employers continued to account for the growth, with 24,600 private sector jobs added over the year and 5,700 jobs added over the month. Those not seasonally adjusted gains offset losses in total government employment, which was 347,800 in May, down 5,200 over the year and 1,200 over the month.
"The key trend is that private sector employers are continuing to hire and create new jobs, while some major industries are ramping up for expansions," said LWC Executive Director Curt Eysink.
The BLS uses a survey of more than 6,000 employers around the state to calculate nonfarm employment. The survey queries employers on the number of people working in their place of work, and captures a broad cross section of industry sectors.
The BLS uses a separate survey of about 600 households to estimate the civilian labor force and to compute the unemployment rate for metro areas and the state as well as the civilian labor force. In May, the state's not seasonally adjusted civilian labor force – the number of people employed plus those looking for work – grew to 2,107,914, an increase of 17,800 over the year and 24,260 over the month.
The number of employed grew to 1,961,135 in May, up 7,500 over the year and 6,525 over the month. The number of unemployed was 146,779, up 10,300 over the year and 17,735 over the month.
Louisiana's not seasonally adjusted unemployment rate for May was 7.0 percent, an increase of 0.5 percent over the year and 0.8 percent over the month. The national rate in May was 7.3 percent, a decrease of 0.6 percent over the year and an increase of 0.2 percent over the month.
Not seasonally adjusted unemployment rates increased over the year in all Louisiana metropolitan statistical areas:
• Alexandria, 7.0 percent, up from 6.5 percent in May 2012;
• Baton Rouge, 6.8 percent, up from 6.5 percent;
• Houma, 5.1 percent, up from 4.7 percent;
• Lafayette, 5.3 percent, up from 4.9 percent;
To view the BLS nonfarm estimates for the state, click here: http://data.bls.gov/pdq/querytool.jsp?survey=la.
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Louisiana Media Company, LLC.
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New Orleans, LA 70125
General Number: (504) 486-6161
News Tips: (504) 483-1503
News Room Fax: (504) 483-1543


text:
Course Description:
(3 Units) Course designed to help students further develop their abilities in addressing the complexity of a topic, developing an argument, organizing information, and controlling language. Students successfully completing the course and the final examination will be eligible to register for Writing Proficiency courses.
Two unsuccessful attempts on the Writing Proficiency Screening Test (WPST).


text:
Related Stories
The main focus continued to be on injuries in Packers head coach Mike McCarthy's Monday press conference. Fresh off a thrilling 28-24 victory over the Vikings and Brett Favre the night before, McCarthy said that OL Brady Poppinga (knee) and rookie DE Mike Neal (shoulder) would require season-ending surgeries.
McCarthy also said starting DE Cullen Jenkins, who hurt his calf before the Vikings game, must be considered questionable for next weekend's game against the high-powered Jets.
The way we see it
Jenkins is a key cog up front, but on Sunday evening the defensive line persevered in fine fashion with young defenders B.J. Raji, C.J. Wilson and Jarius Wynn all stepping up in prime time. McCarthy went out of his way to praise the young trio, in addition to ILBs A.J. Hawk, who won a game ball, and Desomnd Bishop.


text:
Vitamin B6
Vitamin B6 is a water-soluble vitamin and is part of the vitamin B complex group. Several forms of the vitamin are known, but pyridoxal phosphate (PLP) is the active form and is a cofactor in many reactions of amino acid metabolism, including transamination, deamination, and decarboxylation. PLP also is necessary for the enzymatic reaction governing the release of glucose from glycogen.
- 1 History
- 2 Forms
- 3 Functions
- 4 Metabolic functions
- 5 Dietary reference intakes
- 6 Food sources
- 7 Absorption and excretion
- 8 Deficiencies
- 9 Toxicity
- 10 Oncology
- 11 Preventive roles and therapeutic uses
- 12 References
- 13 External links
In 1934, the Hungarian physician Paul Gyorgy discovered a substance that was able to cure a skin disease in rats (dermititis acrodynia). He named this substance vitamin B6.[1][2] In 1938, Samuel Lepkovsky isolated vitamin B6 from rice bran. Harris and Folkers in 1939 determined the structure of pyridoxine, and, in 1945, Snell was able to show the two forms of vitamin B6, pyridoxal and pyridoxamine. Vitamin B6 was named pyridoxine to indicate its structural homology to pyridine. All three forms of vitamin B6 are precursors of an activated compound known as pyridoxal 5'-phosphate (PLP), which plays a vital role as the cofactor of a large number of essential enzymes in the human body.
Enzymes dependent on PLP focus a wide variety of chemical reactions mainly involving amino acids. The reactions carried out by the PLP-dependent enzymes that act on amino acids include transfer of the amino group, decarboxylation, racemization, and beta- or gamma-elimination or replacement. Such versatility arises from the ability of PLP to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates.
Overall, the Enzyme Commission has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities.[3]
Seven forms of this vitamin are known:
- Pyridoxine (PN), the form that is most commonly given as vitamin B6 supplement
- Pyridoxine 5'-phosphate (PNP)
- Pyridoxal (PL)
- Pyridoxal 5'-phosphate (PLP), the metabolically active form (sold as 'P-5-P' vitamin supplement)
- Pyridoxamine (PM)
- Pyridoxamine 5'-phosphate (PMP)
- 4-Pyridoxic acid (PA), the catabolite which is excreted in the urine
All forms except PA can be interconverted.
Pyridoxal phosphate, the metabolically active form of vitamin B6, is involved in many aspects of macronutrient metabolism, neurotransmitter synthesis, histamine synthesis, hemoglobin synthesis and function and gene expression. Pyridoxal phosphate generally serves as a coenzyme for many reactions and can help facilitate decarboxylation, transamination, racemization, elimination, replacement and beta-group interconversion reactions.[4] The liver is the site for vitamin B6 metabolism.
Amino acid metabolism[edit]
Pyridoxal phosphate (PLP) is a cofactor in transaminases that can catabolize amino acids. PLP is also an essential component of two enzymes that convert methionine to cysteine via two reactions. Low vitamin B6 status will result in decreased activity of these enzymes. PLP is also an essential cofactor for enzymes involved in the metabolism of selenomethionine to selenohomocysteine and then from selenohomocysteine to hydrogen selenide. Vitamin B6 is also required for the conversion of tryptophan to niacin and low vitamin B6 status will impair this conversion.[4] PLP is also used to create physiologically active amines by decarboxylation of amino acids. Some notable examples of this include: histidine to histamine, tryptophan to serotonin, glutamate to gamma-aminobutyric acid (GABA), and dihydroxyphenylalanine to dopamine.
Vitamin B6 also plays a role in gluconeogenesis. Pyridoxal phosphate can catalyze transamination reactions that are essential for the providing amino acids as a substrate for gluconeogenesis. Also, vitamin B6 is a required coenzyme of glycogen phosphorylase,[4] the enzyme necessary for glycogenolysis to occur.
Lipid metabolism[edit]
Vitamin B6 is an essential component of enzymes that facilitate the biosynthesis of sphingolipids.[4] Particularly, the synthesis of ceramide requires PLP. In this reaction serine is decarboxylated and combined with palmitoyl-CoA to form sphinganine, which is combined with a fatty acyl-CoA to form dihydroceramide. Dihydroceramide is then further desaturated to form ceramide. In addition, the breakdown of sphingolipids is also dependent on vitamin B6 because S1P lyase, the enzyme responsible for breaking down sphingosine-1-phosphate, is also PLP-dependent.
Metabolic functions[edit]
The primary role of vitamin B6 is to act as a coenzyme to many other enzymes in the body that are involved predominantly in metabolism. This role is performed by the active form, pyridoxal phosphate. This active form is converted from the other natural forms found in food: pyridoxal, pyridoxine and pyridoxamine.[5]
Vitamin B6 is involved in the following metabolic processes:
- amino acid, glucose and lipid metabolism
- neurotransmitter synthesis
- histamine synthesis
- hemoglobin synthesis and function
- gene expression
Amino acid metabolism[edit]
Pyridoxal phosphate is involved in almost all amino acid metabolism, from synthesis to breakdown.
- Transamination: Transaminase enzymes needed to break down amino acids are dependent on the presence of pyridoxal phosphate. The proper activity of these enzymes is crucial for the process of moving amine groups from one amino acid to another.
- Trans-sulfuration: Pyridoxal phosphate is a coenzyme needed for the proper function of the enzymes cystathionine synthase and cystathionase. These enzymes work to transform methionine into cysteine.
- Selenoamino acid metabolism: Selenomethionine is the primary dietary form of selenium. Pyridoxal phosphate is needed as a cofactor for the enzymes that allow selenium to be used from the dietary form. Pyridoxal phosphate also plays a cofactor role in releasing selenium from selenohomocysteine to produce hydrogen selenide, which can then be used to incorporate selenium into selenoproteins.[4]
- Vitamin B6 is also required for the conversion of tryptophan to niacin, so low vitamin B6 status will impair this conversion.[4]
Neurotransmitter synthesis[edit]
Pyridoxal phosphate-dependent enzymes play a role in the biosynthesis of five important neurotransmitters: serotonin, dopamine, epinephrine, norepinephrine and gamma-aminobutyric acid (GABA).[4] Serine racemase, which synthesizes the neuromodulator D-serine, is also a pyridoxal phosphate-dependent enzyme.
Histamine synthesis[edit]
Pyridoxal phosphate is involved in the metabolism of histamine.[4]
Hemoglobin synthesis and function[edit]
Pyridoxal phosphate aids in the synthesis of hemoglobin, by serving as a coenzyme for the enzyme ALA synthase.[6] It also binds to two sites on hemoglobin to enhance the oxygen binding of hemoglobin.[4]
Gene expression[edit]
It transforms homocysteine into cystathionine then into cysteine. Pyridoxal phosphate has been implicated in increasing or decreasing the expression of certain genes. Increased intracellular levels of the vitamin will lead to a decrease in the transcription of glucocorticoid hormones. Also, vitamin B6 deficiency will lead to the increased expression of albumin mRNA. Also, pyridoxal phosphate will influence gene expression of glycoprotein IIb by interacting with various transcription factors. The result is inhibition of platelet aggregation.[4]
Dietary reference intakes[edit]
|Life Stage Group
0–6 months
7–12 months
1–3 yrs
4–8 yrs
9–13 yrs
14–18 yrs
19–50 yrs
50–>70 yrs
9–13 yrs
13–18 yrs
19–50 yrs
50–>70 yrs
<18 yrs
19–50 yrs
<18 yrs
19–50 yrs
The Institute of Medicine notes, "No adverse effects associated with vitamin B6 from food have been reported. This does not mean that there is no potential for adverse effects resulting from high intakes. Because data on the adverse effects of vitamin B6 are limited, caution may be warranted. Sensory neuropathy has occurred from high intakes of supplemental forms."[7] See the full Dietary Reference Intake Table [8] from the Institute of Medicine.
Food sources[edit]
Vitamin B6 is widely distributed in foods in both its free and bound forms. Good sources include meats, whole grain products, vegetables, nuts and bananas. Cooking, storage, and processing losses of vitamin B6 vary and in some foods may be more than 50%,[9] depending on the form of vitamin present in the food. Plant foods lose the least during processing, as they contain mostly pyridoxine, which is far more stable than the pyridoxal or pyridoxamine found in animal foods. For example, milk can lose 30 to 70% of its vitamin B6 content when dried.[4] Vitamin B6 is found in the germ and aleurone layer of grains, and milling results in the reduction of this vitamin in white flour. Freezing and canning are other food processing methods that result in the loss of vitamin B6 in foods.[10]
The best natural sources include avocados, brewer's yeast, wheat bran, wheat germ, liver, kidney, heart, blackstrap molasses, milk, eggs, beef.[11][12]
Absorption and excretion[edit]
Vitamin B6 is absorbed in the jejunum and ileum via passive diffusion. With the capacity for absorption being so great, animals are able to absorb quantities much greater than necessary for physiological demands. The absorption of pyridoxal phosphate and pyridoxamine phosphate involves their dephosphorylation catalyzed by a membrane-bound alkaline phosphatase. Those products and non-phosphorylated vitamers in the digestive tract are absorbed by diffusion, which is driven by trapping of the vitamin as 5'-phosphates through the action of phosphorylation (by a pyridoxal kinase) in the jejunal mucosa. The trapped pyridoxine and pyridoxamine are oxidized to pyridoxal phosphate in the tissue.[4]
The products of vitamin B6 metabolism are excreted in the urine, the major product of which is 4-pyridoxic acid. It has been estimated that 40–60% of ingested vitamin B6 is oxidized to 4-pyridoxic acid. Several studies have shown that 4-pyridoxic acid is undetectable in the urine of vitamin B6 deficient subjects, making it a useful clinical marker to assess the vitamin B6 status of an individual.[4] Other products of vitamin B6 metabolism that are excreted in the urine when high doses of the vitamin have been given include pyridoxal, pyridoxamine, and pyridoxine and their phosphates. A small amount of vitamin B6 is also excreted in the feces.
The classic clinical syndrome for B6 deficiency is a seborrhoeic dermatitis-like eruption, atrophic glossitis with ulceration, angular cheilitis, conjunctivitis, intertrigo, and neurologic symptoms of somnolence, confusion, and neuropathy.[13]
While severe vitamin B6 deficiency results in dermatologic and neurologic changes, less severe cases present with metabolic lesions associated with insufficient activities of the coenzyme pyridoxal phosphate. The most prominent of the lesions is due to impaired tryptophan-niacin conversion. This can be detected based on urinary excretion of xanthurenic acid after an oral tryptophan load. Vitamin B6 deficiency can also result in impaired transsulfuration of methionine to cysteine. The pyridoxal phosphate-dependent transaminases and glycogen phosphorylase provide the vitamin with its role in gluconeogenesis, so deprivation of vitamin B6 results in impaired glucose tolerance.[4]
A deficiency of vitamin B6 alone is relatively uncommon and often occurs in association with other vitamins of the B complex. The elderly and alcoholics have an increased risk of vitamin B6 deficiency, as well as other micronutrient deficiencies.[14] Renal patients undergoing dialysis may experience vitamin B6 deficiency. Also, patients with liver disease, rheumatoid arthritis, women with type 1 diabetes, and those infected with HIV also appear to be at risk, despite adequate dietary intakes.[15][16] The availability of vitamin B6 to the body can be affected by certain drugs such as anticonvulsants and corticosteroids.[10] The drug isoniazid (used in the treatment of tuberculosis), and cycloserine, penicillamine, and hydrocortisone all interfere with vitamin B6 metabolism. These drugs may form a complex with vitamin B6 that is inhibitory for pyridoxal kinase, or they may positively displace PLP from binding sites.[17]
Clinical assessment of vitamin B6[edit]
The biochemical assessment of vitamin B6 status is essential, as the clinical signs and symptoms of its deficiency are very nonspecific.[18] The three biochemical tests most widely used are the activation coefficient for the erythrocyte enzyme aspartate aminotransferase, plasma pyridoxal phosphate (PLP) concentrations, and the urinary excretion of vitamin B6 degradation products, specifically urinary pyridoxic acid. Of these, plasma PLP is probably the best single measure, because it reflects tissue stores.[19] When plasma pyridoxal phosphate is less than 10nmol/L, it is indicative of vitamin B6 deficiency.[19] A PLP concentration greater than 20nmol/L has been chosen as a level of adequacy for establishing Estimated Average Requirements and Recommended Daily Allowances in the USA.[20] Urinary 4-pyridoxic acid is also an indicator of vitamin B6 deficiency; levels of less than 3.0 mmol/day is suggestive of vitamin B6 deficiency.[21]
Adverse effects have been documented from vitamin B6 supplements but never from food sources. This article discusses only the safety of the common supplemental form of vitamin B6, pyridoxine (for a full discussion please see pyridoxine). Toxicologic animal studies identify specific destruction of the dorsal root ganglia[22] which is documented in human cases of overdosage of pyridoxine.[23] Although it is a water-soluble vitamin and is excreted in the urine, doses of pyridoxine in excess of the RDI over long periods of time result in painful and ultimately irreversible neurological problems.
The primary symptoms are pain and numbness of the extremities. In severe cases, there may also be motor neuropathy with "slowing of motor conduction velocities, prolonged F wave latencies, and prolonged sensory latencies in both lower extremities" causing difficulty in walking.[24] Sensory neuropathy typically develops at doses of pyridoxine in excess of 1,000 mg per day but adverse effects can occur with much less and, therefore, doses over 200 mg are not considered safe.[25] Symptoms among women taking lower doses have been reported.[26] Two reported cases of neuropathy with pyridoxine treatment of 24 and 40 mg/day may have been coincidental.[25] This condition is usually reversible when supplementation is stopped.[27]
Existing authorisations and valuations vary considerably worldwide. In 1993, the European Community Scientific Committee on Food defined intakes of 50 mg of vitamin B6 per day as harmful and established a tolerable upper intake level of 25 mg/day for adults in 2000.
The Expert Group on Vitamins and Minerals of the Food Standard Agency UK (UK EVM) derived a safe upper level (SUL) of 10 mg/day for a 60-kg adult in 2003.
The tolerable upper limit has been set by the US FDA at 100 mg/day in 2000.[28] The nutrient reference values in Australia and New Zealand recommend an upper limit of 50 mg a day in adults. "The same figure was set for pregnancy and lactation as there is no evidence of teratogenicity at this level. The UL was set based on metabolic body size and growth considerations for all other ages and life stages except infancy. It was not possible to set a UL for infants, so intake is recommended in the form of food, milk or formula." "The ULs were set using results of studies involving long-term oral administration of pyridoxine at doses of less than 1g/day (Berger & Schaumburg 1984, Bernstein & Lobitz 1988, Dalton 1985, Dalton & Dalton 1987, Del Tredici et al 1985, FNB:IOM 1998, Parry & Bredesen 1985). A NOAEL (No-observed-adverse-effect level) of 200 mg/day was identified from the studies of Bernstein & Lobitz (1988) and Del Tredici et al (1985). These studies involved subjects who had generally been on the supplements for five to six months or less. The study of Dalton and Dalton (1987), however, suggested the symptoms might take substantially longer than this to appear. In this latter retrospective survey, subjects who reported symptoms had been on supplements for 2.9 years, on average. Those reporting no symptoms had taken supplements for 1.9 years."[29]
Because no placebo-controlled studies show therapeutic benefits of high doses of pyridoxine, and the well-documented occurrence of significant toxic effects, there is little reason to exceed the RDI using supplements unless under medical supervision e.g. in treatment of primary hyperoxaluria.
Vitamin B6 intake is inversely associated with the risk of colorectal cancer.[30]
Preventive roles and therapeutic uses[edit]
Vitamin B6 has been used to treat nausea and vomiting in early pregnancy for decades, commonly in conjunction with other medications such as metoclopramide or doxylamine. Alone, it has been found safe and effective, though any woman's prenatal caregiver must help guide treatment for these symptoms.[31]
At least one preliminary study has found this vitamin may increase dream vividness or the ability to recall dreams.[32] This effect is possibly due to the role this vitamin plays in the conversion of tryptophan to serotonin.[32] Anecdotal evidence suggests supplemental vitamin B6 may be associated with lucid dreaming.[citation needed]
The intake of vitamin B6, from either diet or supplements, could cut the risk of Parkinson's disease in smokers by half, according to a prospective study from the Netherlands.[33]
Pyridoxine has a role in preventing heart disease. Without enough pyridoxine, the compound homocysteine builds up in the body. Homocysteine damages blood vessel linings, setting the stage for plaque buildup when the body tries to heal the damage. Vitamin B6 prevents this buildup, thereby reducing the risk of heart attack. Pyridoxine lowers blood pressure and blood cholesterol levels and keeps blood platelets from sticking together. All of these properties work to keep heart disease at bay.[34][unreliable source?]
Nutritional supplementation with high dose vitamin B6 and magnesium is one of the most popular alternative medicine choices for autism, but randomised control trials have had mixed results and small sample sizes mean no conclusions can be drawn as to the efficacy of this treatment.[35][36]
Some studies suggest the vitamin B6-magnesium combination can also help attention deficit disorder, citing improvements in hyperactivity, hyperemotivity/aggressiveness and improved school attention.[37]
If people are marginally deficient in vitamin B6, they may be more susceptible to carpal tunnel syndrome (CTS). CTS is characterized by pain and tingling in the wrists after performing repetitive movements or otherwise straining the wrist regularly.[34] Vitamin B6 has been shown in at least two small-scale clinical studies[38][39] to have a beneficial effect on the syndrome, particularly in cases where no trauma or overuse etiology is known.
Vitamin B6 has long been publicized as a cure for premenstrual syndrome (PMS). Study results conflict as to which symptoms are eased, but most confirm women who take B6 supplements have reductions in bloating, breast pain, and premenstrual acne flare, a condition in which pimples break out about a week before a woman's period begins. Strong evidence suggests pyridoxine supplementation, starting 10 days before the menstrual period, prevents most pimples from forming. This effect is caused by the vitamin's role in hormone and prostaglandin regulation. Skin blemishes are typically caused by a hormone imbalance, which vitamin B6 helps to regulate.[34][unreliable source?]
Mental depression is another condition which may result from low vitamin B6 intake. Because of pyridoxine's role in serotonin and other neurotransmitter production, supplementation often helps depressed people feel better, and their moods improve significantly. It may also help improve memory in older adults.[34][unreliable source?] However, the effectiveness as treatment for PMS, PMDD, and clinical depression is debatable.[40][41]
Ingestion of vitamin B6 possibly can alleviate some of the many symptoms of an alcoholic hangover and morning sickness from pregnancy. This might result from its mild diuretic effect.[42] Though the mechanism is not known, results show pyridoxamine has therapeutic effects in clinical trials for diabetic nephropathy.[43]
Larsson et al. have shown vitamin B6 intake and pyridoxal phosphate (PLP) levels are inversely related to the risk of colon cancer. While in their study the correlation with B6 intake was moderate, it was quite dramatic with PLP levels, where the risk of colon cancer was decreased by nearly half.[44]
Vitamin B6 is also known to increase the metabolism of Parkinson's medications, such as levodopa,[citation needed] and should be used cautiously.
- ^ Paul Gyorgy (1934) "Vitamin B2 and the pellagra-like dermatitis in rats," Nature, vol. 133, pages 498–499.
- ^ György P, Eckardt RE (September 1940). "Further investigations on vitamin B(6) and related factors of the vitamin B(2) complex in rats. Parts I and II.". Biochem J. 34 (8–9): 1143–54. PMC 1265394. PMID 16747297.
- ^ Enzyme Nomenclature
- ^ a b c d e f g h i j k l m n Combs, G.F. The Vitamins: Fundamental Aspects in Nutrition and Health. 2008. San Diego: Elsevier
- ^ Lichtstein HC, Gunsalus IC, Umbreit WW (1945). "Function of the vitamin B6 group; pyridoxal phosphate (codecarboxylase) in transamination" (PDF). J Biol Chem. 161 (1): 311–20. PMID 21005738.
- ^ "Heme Synthesis". Rpi.edu. doi:10.1042/BJ20030513. Retrieved 2012-11-02.
- ^ Food and Nutrition Board. Institute of Medicine. "Dietary Reference Intakes: Vitamins". National Academies, 2001.
- ^ http://www.iom.edu/~/media/Files/Activity%20Files/Nutrition/DRIs/DRI_Vitamins.ashx
- ^ McCormick, D. B. Vitamin B6 In: Present Knowledge in Nutrition (Bowman, B. A. and Russell, R. M., eds), 9th edition, vol. 2, p.270. Washington, D.C.: International Life Sciences Institute, 2006.
- ^ a b Sauberlich H. Vitamins -how much is for keeps? Nutr Today 1987; 22:20–28
- ^ Earl Mindell The Vitamin Bible, Arlington Books, 1982
- ^ "09038, Avocados, raw, California". National Nutrient Database for Standard Reference, Release 26. United States Department of Agriculture, Agricultural Research Service. Retrieved 14 August 2014.
- ^ Andrews' Diseases of the Skin, 10th Edition, Elsevier.
- ^ Bowman, B.A., Russell, R. M. Present Knowledge in Nutrition. 9th Edition. Washington, DC: ILSI Press; 2006; pg.273
- ^ Rall L.C., Meydani S.N. (1993). "Vitamin B6 and immune competence". Nutrition Reviews 51 (8): 217–225. doi:10.1111/j.1753-4887.1993.tb03109.x. PMID 8302491.
- ^ Massé, PG; Boudreau, J; Tranchant, CC; Ouellette, R; Ericson, KL (2012). "Type 1 diabetes impairs vitamin B(6) metabolism at an early stage of women's adulthood". Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 37 (1): 167–75. doi:10.1139/h11-146. PMID 22288928.
- ^ Bhagavan H.N. (1985). "Interraction between vitamin B6 and drugs". In Reynolds R.D., Leklem J.E. Vitamin B6: Its role in Health and Disease. New York: Liss. pp. 401–415.
- ^ Gibson R.S. (2005). "Assessment of vitamin B6 status.". Principles of Nutritional Assessment (2nd ed.). New York: Oxford University Press. pp. 575–594.
- ^ a b Liu A.,Lumeng L., Aronoff G., Li T-K. (1985). "Relationship between body store of vitamin B6 and plasma pyridoxal-P clearance: metabolic balance studies in humans". Journal of Laboratory and Clinical Medicine 106 (5): 491–497. PMID 4056565.
- ^ Food and Nutrition Board Institute of Medicine (1998). Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press.
- ^ Leklem J (1990). "Vitamin B-6: A status report". J. Nutr 120: 1503–1507. PMID 2243296.
- ^ Perry TA, Weerasuriya A, Mouton PR, Holloway HW, Greig NH. Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy. Exp Neurol2004, 190, 133–144
- ^ Schaumburg H, Kaplan J, Windebank A, Vick N, Rasmus S, Pleasure D, Brown MJ. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983, 309, 445–448.
- ^ Foca FJ (September 1985). "Motor and sensory neuropathy secondary to excessive pyridoxine ingestion". Arch Phys Med Rehabil. 66 (9): 634–6. PMID 2994596.
- ^ a b Katan MB (Nov 12, 2005). "[How much vitamin B6 is toxic?]". Ned Tijdschr Geneeskd. 149 (46): 2545–6. PMID 16320662.
- ^ http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0404.1987.tb03536.x/abstract
- ^ Vitamin and Mineral Supplement Fact Sheets Vitamin B6
- ^ The EFSA Journal (2008) 760, 1–13
- ^ NHMRC Nutrient Reference Values - Nutrients vitamin B6
- ^ Larsson SC, Orsini N, Wolk A (March 2010). "Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies". JAMA 303 (11): 1077–83. doi:10.1001/jama.2010.263. PMID 20233826.
- ^ Sheehan P. Hyperemesis gravidarum--assessment and management. Aust Fam Physician. 2007 Sep;36(9):698–701.
- ^ a b Ebben, M.; A Lequerica; A Spielman (2002). "Effects of Pyridoxine on Dreaming: a Preliminary Study". Perceptual and Motor Skills 94 (1): 135–40. doi:10.2466/pms.2002.94.1.135. PMID 11883552. Retrieved 2012-05-23. "The effect of pyridoxine (Vitamin B-6) on dreaming was investigated in a placebo, double-blind study to examine various claims that Vitamin B-6 increases dream vividness or the ability to recall dreams."
- ^ "Increased intake of vitamin B6Sheet". Retrieved 2006-08-11.
- ^ a b c d TLC Cooking "Benefits of Vitamin B6"
- ^ Pfeiffer SI, Norton J, Nelson L, Shott S (October 1995). "Efficacy of vitamin B6 and magnesium in the treatment of autism: a methodology review and summary of outcomes". Journal of Autism and Developmental Disorders 25 (5): 481–93. doi:10.1007/BF02178295. PMID 8567594.
- ^ Angley M, Semple S, Hewton C, Paterson F, McKinnon R (2007). "Children and autism—part 2—management with complementary medicines and dietary interventions" (PDF). Aust Fam Physician 36 (10): 827–30. PMID 17925903.
- ^ Mousain-Bosc M et al. (2006). "Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders". Magnesium Research 19 (1): 46–52. PMID 16846100.
- ^ Ellis J et al. (Oct 1979). "Clinical results of a cross-over treatment with pyridoxine and placebo of the carpal tunnel syndrome". Am J Clin Nutr 32 (10): 2040–6. PMID 484522.
- ^ Kasdan ML, Janes C.: Carpal tunnel syndrome and vitamin B6. Plast Reconstr Surg. 1987 Mar;79(3):456–62.
- ^ Vitamin Pills: Popping Too Many?, WebMD
- ^ "Vitamin B6 Therapy for PMDD", Complementary and Alternative Medicine, Creighton University School of Medicine
- ^ Ebbets, Russ. "The Mysterious Vitamin B6". USATF Niagara. Archived from the original on 2007-03-26. Retrieved 2012-05-14.
- ^ Sergi V.C., Wenhui Zhang, Billy G.H., Anthony S.S., Paul A.V. Pyridoxamine protects proteins from functional damage by 3-Deoxyglucosone; mechanism of action of pyridoxamine. Biochemistry 2008, 47, 997–1006.
- ^ Larsson, S. et al. JAMA 2010; 303:1077–1083.
External links[edit]
- Facts about Vitamin B6 from Office of Dietary Supplements at National Institutes of Health
- The B6 database A database of B6-dependent enzymes at University of Parma
- COT statement on vitamin B6 (pyridoxine) toxicity (June 1997) (Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT))
- Vitamin B6 at the US National Library of Medicine Medical Subject Headings (MeSH)


text:
While we're basking in Olympic spirit, let's pay tribute to our local Olympians.
Let's start by taking inventory.
How many Olympians have we had from Marin County through the years? We can consider those who were born here, those who grew up here or those who lived here late in life. Shoot, anybody who had a cup of coffee here could be claimed as a local, right?
We've had some ace swimmers ( Ann Curtis Cuneo, Rick DeMont), some stellar sailors ( Paul Cayard, John Kostecki), a sprinter ( Archie Williams) and a freestyle skier ( Jonny Moseley). Of those, DeMont and Moseley were the most homegrown.
That just a list to get us started. Who are we missing? What are your favorite memories of watching our locals at the Games? Share your comments below.


text:
Select Route:
Voice from the Dust is another of those obscure, yet good, long free lines in Zion. It seems that every other pitch on this thing is great. That also means that every other pitch is not so great. There is a good topo at the visitor center.
Standard desert rack with multiples in finger- to hand-size. Bring a big piece for the wide start on pitch 5; although manageable, it is unprotectable without it. See the topo for a detailed gear list.
The route starts on a heavily huecoed face on the far south end of the east face. The first pitch starts in a short chimney to the right of some large huecos and roofs. See beta photo.
Rappel the route, skipping the belay at the top of pitch 5. You can rappel from the top of pitch two to the ground.


text:
We've been running around the Adobe Summit 2012 show floor, interviewing folks on camera about their experiences. Our Summit Insiders, Michele Kiss and Ben Gaines, interview everyone from Salt Palace Convention Center staff to executives, some entertaining tidbits and some enlightening things too.
If you are with us at the Salt Palace, you may have seen them on one of the 27 TV's around the venue. For everyone else couldn't join us in person, watch them below!
Adobe Summit 2012 Day One Keynote Reactions
Flavors of Summit 2012
What are You Learning at Adobe Digital Marketing Summit 2012?
CMO Panel at Adobe Summit 2012


text:
Expired Property Listing
This property is disabled.
ESJ Towers Ocean Front Condo Hotel in Puerto Rico
- bedrooms 2
- baths 1½
- sleeps 6
- pool yes
- hot tub yes
- pets allowed no
- type Condo
- community San Juan
rates (USD)
/ night
$ 1,050 - $ 1,750 / week
vacation rental description
Beautiful 2 bedroom apartment in the ESJ Towers on the finest beachin Puerto Rico. Within the area are major hotels and attractions,
including the El San Juan Hotel and Casino, " Pueblo" supermarket.
Please call for more availabilities in the ESJ Towers for
- Studios
- One bedroom
- Two bedroom
- Three bedroom
Please call for special "Last Minuets Deal"
condo rental amenities
1 1/2 bathrooms
Telephone line
Washer and dryer
Fully equipped kitchen with coffee maker and microwave and toaster
Kitchen utensils and plates
King size bed in master bedroom
2 twins in the second bedroom
Big living room
Beautiful ocean view
The hotel has facilities including a Olympic size swimming pool,
jaccuzi, sauna, gym, restaurant and bar, mini market, high speed
internet access, video game room and ping pong room, billiard tables,
a card room.
activities and attractions in Puerto Rico Caribbean
We are located next to the El San Juan Hotel and Casino, major
restaurants, water sport in the beach, we have a concierge desk where
you can book a tour all over the island which provides
scuba diving, snorkeling, kayaks, banana boat, para sailing. Direct
access to the beach.
vacation rental rates
April 15 - December 15
Daily - $155-$185
Monthly - $2500
December 15 - April 15
Daily - $225-$275
Monthly - $3500-$3700


text:
I like it--restrained, elegant, and classic. James Bond might pull this from his jacket pocket if called upon to cut a twist of lemon for his martini.
It is exactly what James Bond would use!
Beautiful, as always!
Take a look around at: www.sharpandshinyshop.com
Email me at: email@example.com
Beautiful knife, Pierre! As we've come to expect from you.
That would go real well with my ivory knife collection. Oh.... wait, I don't have an ivory knife collection. They all flew the coop. sad face.
I haven't lived the life I wanted, just the lives I needed too at the time.
awesome work brother!
I haven't lived the life I wanted, just the lives I needed too at the time.
Let those smiles back out Son, still got a few tricks up my sleeve!
Looks great. I use your my Rodrigue parer frequently, whoever get this one is in for a real treat.
That is amazing Pierre. Strong work.
"In Japan they don't call it Japanese food, they just call it food." -- Children's Hospital Quote


text:
Andes & Altiplano Trek
Combine a remote trek to Machu Picchu with an exhilarating trek in Bolivia's Condoriri range
Combine a remote trek to Machu Picchu with an exhilarating trek in Bolivia's Condoriri range
Experience one of Peru's best treks and the delights of Cusco
Travel to Peru to retrace the steps of the Inca, Peru's fascinating ancient civilisation. Follow the Inca traditions from Cuzco, through the fertile heartland of the Sacred Valley and Ollantaytambo before reaching the magnificent Machu Picchu. This action-filled Peruvian tour gets you closer to the secrets of this elusive civilisation on a breathtaking adventure.
Travel through the soaring Inca heartland, from the beaches of Lima to the streets of Cuzco, high up in the Andes. Unlock the secrets of the many mystic sights as you explore the streets of Arequipa, trek along historic Inca pathways, explore the wildlife-studded Ballestas Islands and ramble over the ruins of Machu Picchu.
Explore one of world's deepest canyons and the 'white city' of Arequipa
View the spectacular Nazca Lines and the Ballestas Islands (mini-Galapagos) by boat
An ideal short jungle adventure into the Tambopata Reserve exploring the jungle on foot and by boat and experiencing the prolific birdlife of the Amazon rainforest
This adventure takes you through the centre of ancient Inca heartlands on a short but sweet Overland tour. Travel through Peru and Bolivia and discover the secrets of these mystical places as you explore the streets of Cuzco, trek along ancient Inca pathways, visit the islands dotting Lake Titicaca and ramble over the impressive Machu Picchu ruins.
Traverse via the lost ruins of Choquequirau to Machu Picchu
A remote trekking experience along uncrowded trails to view snow capped Andean peaks, the enigmatic Machu Picchu and to experience Andean culture first hand
An exhilarating itinerary combining many of Peru's highlights
Visit South America and travel through Peru from Cuzco to Lima. Uncover ancient mysteries and discover the rich culture of this unique corner of the globe. Starting in Cuzco, the heart and soul of Peru, this exceptional Overland adventure includes an unforgettable trek through spectacular Andean scenery taking in ancient ruins and stopping at remote villages.
Ultimate multi activity trip from Cusco to Machu Picchu
An exhilarating journey through the cultural heart of Peru
Journey from Cusco to La Paz via Lake Titicaca
Explore Cusco, the Sacred Valley and Machu Picchu


text:
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Black Forest Schwarzbier - Black Forest Brew Haus
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Ratings: 7 | Reviews: 7 | Display Reviews Only:
New York
4.38/5 rDev +7.9%
64oz growler filled at Black Forest Brew Haus in Farmingdale, NY on 10/10/09. Served in both a pilsner glass and a glass beer mug.
Dark, Black, Schvartze! I got a fluffy tan head on a vigorous pour that hung around for most of the glass and left some sticky lacing.
Roasted coffee bean aroma.
Very good tasting beer, roasted malty sweetness with notes of coffee and bitter chocolate, delicious.
Lighter bodied beer than the taste would lead one to believe, silky smooth feel.
Very easy to drink.
10-10-2009 23:31:48 | More by JoeyBeerBelly
New York
4.25/5 rDev +4.7%
Pours a near black color with a dense tan colored head that settles into a chunky ring with slight lacing. The aroma is of roasted malt, charcoal/ash, and semi-sweet chocolate. The taste is much like the aroma, nice roasted malt, nothing over the top, perfect for the style. This is followed by some coffee and chocolate flavors with a slight metallic (copper) twang. Light to moderate feel, crisp, fizzy carbonation, finishes with a light roasted malt bitterness. This is a very nice schwarzbier. Nice roasted flavor yet very crisp and drinkable. I'm happy a picked up a growler of this bad boy.
09-27-2009 01:51:50 | More by Gmann
New York
4.03/5 rDev -0.7%
Poured a deep brown hue with a one finger creamy white head. There was very good retention and lacing.
The smell featured a nice roasted grain with some touches of dark chocolate and caramel.
The taste consisted of some subtle coffee notes, some smoke and an earthy hop.
The mouthfeel was of average fullness for the style.
Overall a very good black beer. very easy to drink.
09-23-2008 02:34:13 | More by plaid75
New York
4.1/5 rDev +1%
Poured from 64 oz. growler a nice black color when held to the light it appears a brownish red on the edges. Minor head and lacing.
Aroma is mostly of roasted malts,coffee (maybe some smoked aroma), with some sweet malt.
Pretty well balanced with the sweet malt flavor backed up with a dry bitter roasted malt finish (chocolate then coffee)
By the end of this growler I split with my Brother I would have preferred a fuller body or some more carbonation. However, at the beginning I did enjoy it. It was light, but not too thin.
According to the chalkboard at the Brew Haus this beer was 5.5%. And I easily enjoyed the several beers I had out of this growler with my Brother. Some people have problems drinking a dark beer all not even if it has a lighter mouthfeel and body like a schwarzbier. Just some psychological thing, but I would have no problem drinking this again or drinking this throughout the night.
09-10-2007 04:18:12 | More by shaebs99
4/5 rDev -1.5%
This one was a free sample at the brewery. It was a lovely dark brown color, but by the time I got it there was no head to speak of.
The aroma was of rich malt, and was quite sweet. Much more so than I would have expected for a schwarzbier, but it was pleasant.
The taste was of very strong, roasted chocolate malt. Very nice. I enjoyed this one.
06-29-2004 02:43:01 | More by connecticutpoet
3.85/5 rDev -5.2%
Appearance: Clear dark brown (almost black) with a slight reddish tint when held up to the light. Thick tan head.
Smell: Slight malt aroma.
Taste: Malt sweetness flavor up front, along with slightly roasted toffee and chocolate flavors. Good bitter aftertaste, which became more pronounced as I drank more of the beer. Enjoyable taste.
Mouthfeel: A little thin.
Drinkability: Very drinkable.
Comments: I enjoyed this beer. Some of the flavors are subtle and become more noticeable as you drink more of this (as opposed to first few sips).
03-02-2003 11:15:25 | More by Denali
New York
3.8/5 rDev -6.4%
Appearance: DARK brown almost black...but when held to light there was a hint of ruby color...thin dark tan head
Aroma: Slightly sweet
Taste: Sweet at first mixed with roasted malt hint of caramel and finished dry...Great flavors, however a little too sweet in the beginning
Drinkability: Once you get over the sweet taste, you can drink alot...but I just couldn't...
Overall a good beer
03-02-2003 10:31:36 | More by stegmakk
Black Forest Schwarzbier from Black Forest Brew Haus
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Why College Makes Sense for Your Kid
By Larry Light, Editor-in-Chief
Aug. 1, 2014
College? Isn't it too expensive? And given high unemployment among Millennials, what's the point anyway? Financial advisors increasingly wrestle with these questions. Clients want to know whether the exercise is worthwhile.
The overwhelming answer is: Yes. We'll discuss this in a minute. But it is darned expensive, with higher education costs as much as $60,000 per year. Well, there are remedies for that problem.
In that spirit, we're running a sweepstakes for a free college education in conjunction with National Financial Advisor Week, Sept. 15-19. Run by our parent organization, AIQ Inc., this contest will cover expenses for a student entering a four-year college in fall 2016. Other ways of paying for college include 529 savings plans and student aid, which you can find out about at studentaid.ed.gov.
Barry Glassman, founder of Glassman Wealth Services in McLean, Va., wrote in an article for us: "You want to give your children the best chance of success. Funding their education is one of the best ways to do this."
College is worthwhile, the record shows. As David Leonhardt writes in the New York Times: "For all the struggles that most young college graduates face, a four-year degree has probably never been more valuable." According to the Economic Policy Institute, getting a four-year degree allows you to earn almost double what those without one make.
In fact, MIT economist David Autor, writing in the journal Science, calculates that the real cost of college is negative $500,000. In other word, over a lifetime, grads' superior earnings eclipse the college price tag. It's a half-million-dollar benefit to graduates.
Young people (ages 20 through 24) with a college degree had half the unemployment rate of those without. Moreover, stats from the National Center for Education Statistics show that 83% of those who graduated in spring 2008, right before the worst financial cataclysm since the Great Depression, are working today. While the flip side of that is that 17% are not working, note that people pursuing graduate degrees are in that 17%.
So when you are planning with your advisor about how to chart your offspring's future, remember that the more education they get, the better. They will thank you for it.