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Who can resist Smartwool® Snowflake Flurry Socks on a cooler day? This naturally moisture-wicking, breathable and antibacterial sock with pleasing graphic design features WOW™ technology for added comfort in key areas.
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Make your feet more comfortable with Sockwell® Circulator Meta Cushion Socks. Constructed to help relieve foot pain, these therapeutic socks feature MRT, which distributes weight over the forefoot pressure zone and minimizes the burning sensation at ball of foot. To maximize circulation and support your muscles, they offer 15-20mmHg Graduated compression.
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Power cut hits south Herefordshire (From Hereford Times)
Get involved! Send your photos, video, news & views by texting HT NEWS to 80360 or e-mail us
Power cut hits south Herefordshire
Updated 9:40am Friday 13th June 2014 in News
POWER cuts knocked out the electricity to around 3,300 houses in Herefordshire on Thursday as temperatures hit 22 degrees celcius.
Engineers from Western Power were able to divert power and reconnect all but 400 homes within half an hour.
Those still without power are largely in the Belmont area, however other parts of the city may experience dips in power at the engineers try to establish the cause of the cut.
Heatwaves have long been linked to power cuts, and Hereford this afternoon ranked in the top-five hottest places in the UK, according to BBC Weather.
Comments (4)
Please log in to enable comment sorting
6:59pm Thu 12 Jun 14
yokelyokel says...
That really is the mother of all heatwaves and it's no wonder the power went down. Temperatures really did soar, didn't they.
I must go out and fry an egg on the pavement. I may be some time.
8:39pm Thu 12 Jun 14
The Russian 1 says...
9:23am Fri 13 Jun 14
mizza21 says...
We should invite the England team over for their hot weather conditioning in the garden.
10:10pm Sat 14 Jun 14
yokelyokel says...
That is why there was a bit of mocking before one of the HT grownups read what had been published and got a bit embarrassed and changed it.
Comments are closed on this article.

subset: commoncrawl


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Lékué Collapsible Mixing Bowl
Experience the convenience of Lékué's signature platinum silicone with this collapsible mixing bowl. Perfect for melting chocolate or softening butter in the microwave, bowl features sturdy handles and edges for easy transport and is collapsible for space-saving storage when not in use.
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Our attractive lemon-shaped prep bowls brighten any room and are...
Now: $11.99
Was: $19.95


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Thread: LT deal...what do you think?
08-20-2004, 05:36 PM #1Rookie
- Join Date
- Dec 1969
- Posts
- 145
LT deal...what do you think?
i know it's old news now but i was just wondering what people think of ladainian tomlinson's decision to stay with the chargers for the long haul. you kind of have to respect him for that. i know he's making tons of money from the deal but i think just about any team that could afford it probably would have given him the same deal. a lot of players have left teams because they don't like their losing ways, like terrell owens. but this at least shows he is determined to make this team better. consider also that although he was one of the best backs in the afc these last two seasons he did not make the pro bowl. being on the chargers probably had a little to do with that. i just think it was nice to see a player show some loyalty to a team instead of going to whoever is winning right now.
or do you think he signed the deal for totally different reasons?
08-20-2004, 05:43 PM #2Asst. Coach
- Join Date
- Dec 1969
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- 582
LT deal...what do you think?
it's all good he's the best complete rb in the gameHere s the most important thing: You can NEVER lose your sense of humor. Without that, you ve got NOTHING. (Divinci) James Belushi
LT deal...what do you think?
He really needs to leave, he could have a really good chance of winning a super bowl even for a mediocre team, hes just that good. respect the decision,but, a bad one.
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POD: Happy Anniversary
Posted on March 6th, 2013 by Michael Johnson
|From Picture of the Day 2013
Today our 8 year Anniversary, to celebrate I surprised her with some flowers. It's hard to believe that it's been 8 years the time has gone so fast, and now I can't imagine my life without her. I love you Melissa.
Filed under: Family, Picture of the Day


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Hampton edge out Whitgift in Natwest Cup (From Richmond and Twickenham Times)
Contact us: Got a photo? Text 'SLPICS' to 80360. Got a story? Call the newsdesk: 020 8722 6328
Hampton edge out Whitgift in Natwest Cup
Updated 1:06pm Thursday 16th January 2014 in Sport
War of attrition: Whitgift School were strong in defence but Hampton School edged a thriller in Croydon Scrumpix
Hampton School remain on course for a Twickenham final appearance after reaching the last 16 of this year's U18 Natwest Schools Cup.
Hampton, skippered by London Wasps academy star Akira Takenaka, launched a second half comeback to win 11-6 at Whitgift School on Wednesday.
The hosts led 6-0 at half time, but Takenaka's side levelled through two Rory Chatterton penalties and then flanker Paul van der Merwe crossed off the back of a driving maul.
Hampton director of rugby Zoran Higgins said: "Every single one of the 22-man squad contributed to what was a really hard, physical and high quality game of rugby – it would have graced the final at Twickenham.
"Credit to Whitgift, who gave everything and are an outstanding team and we wish all the players and coaches the best for the rest of the season.
"We now have to face Campion who are a very good side and we will not underestimate them."
Hampton now face Campion School in the London and South East A regional final and Takenaka could not hide his delight.
"I am so proud of everyone in the squad and feel that the Hampton boys really showed their heart and passion for the team and the school during the game," he added.
"The feeling at the end of the match was pure elation and relief and we are now really excited about the next round in the Schools Cup."


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"Luxury safari vacations custom designed by Opulent Africa so that your safari holiday in Africa is unique to you."
Klein's camp in the Serengeti.See the migration, excellent game viewing at Klein's camp.
Nightcaps overlooking the Serengeti.Relax on the Serengeti plains.
Klein's Camp in the Serengeti.Refresh in the pool.
Comfortable lodge rooms at Klein's.Relax between game drives..
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The Serengeti National Park in Tanzania plays host to one of the planet's most spectacular wildlife events – the Great Migration.
A massive swathe of plains animals are compelled to sweep across the rolling Serengeti and on into the Masai Mara regardless of what is in their path. Danger is ever present for these huge herds of zebra and wildebeest - on land in the form of gathering numbers of watchful, hungry lion, leopard and cheetah; and in the water crossings lie some of the largest crocodiles in Africa.
The captive panorama is magical to wildlife observers and keen photographers alike and in this area there is excellent luxury safari accommodation in which to feed the body whilst the spirit is uplifted by daily witness of the superb game viewing.
Klein's Camp is a private and remote camp located on the northern border of the Serengeti National Park and set just below the crest of the Kuka Hills. Due to this elevated position the camp overlooks the corridor of land that links the Serengeti to the Masai Mara and as such has full view of the migrating herds across the rolling grasslands during the Migration.
From Arusha Airport a number light aircraft services operate a morning scheduled flight to Klein's own airstrip where guests are met and enjoy a leisurely one hour game drive to the camp.
Aside from the months of the migration this camp, set in a rugged, rolling landscape gives breathtaking views of the surrounding hills and valleys and enjoys excellent game viewing.
The camp comprises of ten intimate cottages constructed of white washed local stone with wooden floors, classically furnished interiors with comfortable, canopied double beds and en-suite facilities. A private veranda offers a place to relax and survey the excellent views of the surrounding landscape.
The large, welcoming communal area is open sided and the bar /seated area with deep leather armchairs around a central fireplace (perfect for those cooler evenings) and dining room, serving excellent, freshly prepared meals. There is a pool, ideal for a refreshing dip between game drives, deck area and small safari shop to tempt guests with locally made Maasai crafts.
Whilst children are very welcome at Klein's Camp regrettably those aged under five years of age cannot be accommodated on game drives, however, a child minding service can be arranged.
At Klein's Camp the twice daily game drives by 4 x 4 vehicle are taken in the camp's wilderness concession or in the Serengeti National Park. In fact the camp is the only lodge to offer night drives and game walk in the wilderness concession. The night drives can offer a unique opportunity to see the nocturnal creatures of the area. The game drives are all accompanied by Maasi trackers and community visits can be arranged for guests that want to explore further the local culture and community projects. Bush walks, accompanied by an armed guide and Maasai tracker can also be organised to provide a different game viewing experience.


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Andrew, any comments?
Andrew, any comments?
I will try my best to get this resolved on my end.
Follow @AndrewAtNokia on Twitter for news and updates about Nokia Publish!
Andrew is now on Facebook to assist you with any publishing related inquiries.
Thanks Andrew for your efforts. I'm a programmer and I know that things can go wrong.
But I'm here for just one month, and I think that the things here go wrong very usualy .
Just a Comment
To me and in this "problem", or Nokia in this area have bad programmers (I hope not) or have legacy systems that dont know how to integrate. But this is just my opinion.
But I think that worse than not knowing how much I'm gaining every day, is that I'm unable to do a correct marketing of the app (I'm not sure if the price of my app must go up or down), this for me is the worst.
Of course this is the worse assuming that the accounts are well made.
Last edited by cotonet; 2011-12-04 at 02:56.
Dear Andrew. Tell me, how the lack of updates the statistics on paid applications affected place in the ranking of sales programs for nokia store? It looks like we're losing sales because of your constant problems. And it's not fair that this problem affects only a part of the developers.
So I'm guessing the problem is still going on as I show no sales for Dec yet? Any ETA on when it will be fixed. Up until recently the reports had been working fairly well updating at an acceptable level. What happened?
We have been pleased with our Ovi sales increases and want to keep suppling content but these report issues really make that difficult as we feel like we are doing our part and Nokia is letting us down...
Every month same problem again and again. :-( Are you lacking resources to fix this bug in your reporting system once and for ever? I understand that bugs is usual thing in any software, but seems that you cannot fix it from May. Very annoying. :-(
This time are now 5 days without reports. Too Much.
How 'developer 123' say: "Every month same problem again and again."
We need a definitive solution.
I have also noticed that the list of best sellers is dislodging.
Too many problems.
Thanks for your efforts Andrew.
Andrew, you should be promoted. Also, I suggest you explain to your superiors that the best way to talk with developers is not email because maaaan do you take long to reply (or no reply at all).
For the last 2 weeks, reports began to show erratic behaviour. They stopped working altogether 5 days ago. Team answered saying there's an issue though, so there's that. Any ETAs?
Same.. Like this since 23th Nov. Our last 7 days revenue appear as +0%.. too sad.
They broke it completely.
Not only the reports, because is happening the same thing of the other month: the ovi store positioning its upside down and we dont get views of the customers
Yea...no update of report from 29 th of November..I hope the issue will be resolve quickly.
Now, not working for the last 7 days.
Andrew, any comments?


text:
The 'central core' of most operating systems, the kernel is the component directly responsible for communications between the software and hardware components of a computer.
The kernel's main task is efficiently managing the computer's physical resources (CPU, RAM, etc) so that a user can execute an application (a document editor, a game, etc).
Kernels & Malware
Rootkits pose the greatest danger to kernels, as certain types of rootkits specifically target and manipulate the kernel in order to hide their presence or actions. These are known as kernel-level rootkits.
Kernel-level rootkits typically function by exploiting vulnerabilities found in the kernel. Given the critical importance of the kernel, most security experts will strongly recommend users to keep their computer system updated with the latest patches from their operating system vendors.
A program or hardware component that surreptitiously monitors and stores all the strokes typed into a keyboard. Some keylogger programs will also forward the stored information to an external server for easier retrieval by the attacker.
Keyloggers are typically used by malicious attackers to steal vital information such as personal details, credit card details, online account login credentials and so on. The stolen information can then be used to perpetrate such crimes as identity theft, online fraud, monetary theft and so on.
Types of Keyloggers
There are two types of keylogger programs - software and hardware.
Keylogger programs may be dropped on a system by other malware, or may be manually installed by the attacker. On the other hand, keylogger hardware must be manually installed, which requires the attacker to have physical access to the target machine.
Keylogger programs will often allow an attacker to remotely retrieve the stored information, reducing the amount of risk involved; data stored on keylogger hardware must usually be physically retrieved in order to access the information saved on the device.
Keylogger Malware
Nowadays, keylogging functionality can be found in so many trojans that a distinct sub-type has been developed to distinguish them - Trojan-Spy.
Like most trojans however, a Trojan-Spy can usually only be installed on a victim's computer through various social engineering-based attacks, or an exploit of a vulnerability present on the computer system.
A classification term used by F-Secure to indicate the potential severity of threat a program may pose to the user's computer system and/or confidential information.
About Detection Names
A quick guide to Detections - why they are important, how they work and how to read them. Also includes Generic Detections and how they differ from traditional Detections.


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Main Content
Zip up and head out to the basketball court in the Antigua® NBA youth Frost fleece pullover. The long-sleeve fleece is super soft and warm, and features a ¾-zip placket with an adjustable bungee double-toggle bottom to help keep out the cold. Everyone will know you're a loyal fan when they see the embroidered team graphics proudly displayed on the chest.
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Prepare Your Guts: Game of Thrones BEER Coming in March
Wednesday, December 19, 2012 | awesome, beer, game of thrones beer, ommegang beer, ommegang game of thrones
Now you can drink like a king with this 'Iron Throne Blonde Ale' coming from Ommegang Brewery out of Cooperstown, NY. The beer will be released in tandem with the HBO show on March 31, 2013.
"Iron Throne is a blonde ale at 6.5% ABV and brewed with a robust amount of pils, honey, aroma malts and red wheat. Gentle hopping includes Styrian Golding and Hallertau, appropriately noble hops."
Sounds good enough to soothe any Dothraki's inner dragon.


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Very elegant '38 Ford Convertible Sedan! One of only 2,743 built in 1938! Fitted with its correct 221ci Flathead V8 and 3-speed manual transmission!... More
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One of the greatest things to come out of the explosion in vintage rodding is the rebirth of the flathead Ford V8. This 1939... More
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This 1940 Ford Deluxe Suicide Coupe features a Boss 302 V-8 8cyl Gasoline engine. It is equipped with a 3 Speed Automatic transmission. The... More
Very nice 1951 Ford Custom Convertible. Flathead V-8. Runs very well. Stock except for electric fuel pump and auxilliay cooling system. Difficult to find in... More
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1947 Ford Deluxe V8 Club Coupe, early '50's style kustom. Built by a dedicated well know hobbyist/machinist in the Canton area over many years... More
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This 2-door sedan sports a 283 ci V8 engine with 225 hp and Muncie 4-speed manual transmission. Originally built in 1960 and carefully stored... More


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Selected Publications of Dr. Holz
All downloadable files are in PDF format.
Regulation of glucose homeostasis by GLP-1
Progress in Molecular Biology and Translational Science 2014
This review summarizes the current state of knowledge regarding how GLP-1 influences systemic glucose homeostasis in humans with type 2 diabetes and in various animal models of type 2 diabetes. Also provided is an update concerning GLP-1 based drug development strategies that target the GLP-1 receptor or DPP-IV in order to lower levels of blood glucose.
Identification and characterization of small molecules as potent and specific EPAC2 antagonists.
Journal of Medicinal Chemistry 2013
This paper describes the synthesis and properties of novel small molecule Epac2 antagonists including HJC0350. The specificity of these antagonists was evaluated by the Holz lab in FRET-based assays of Epac2 activation. The work was a collaboration of the Holz laboratory with Drs. Chen, Tsalkova, Mei, Cheng, and Zhou of the University of Texas Medical Branch in Galveston, TX.
Synthesis, characterization and pharmacodynamics of vitamin-B12-conjugated glucagon-like peptide-1.
Chem Med Chem 2013
Vitamin B12 conjugates of GLP-1 are under investigation as orally administrable blood glucose-lowering agents. These conjugates bind to gastric instrinsic factor and undergo intestinal absorption using the body's own B12 uptake mechanism. For this study, the Holz laboratory collaborated with Dr. Robert P. Doyle of the Syracuse University Department of Chemistry in a thesis project of SU graduate student Susan Clardy-James.
Epac2 makes a new impact in beta-cell biology.
Diabetes 2013
This invited Commentary summarizes findings demonstrating that under conditions of insulin resistance induced by a high fat diet, the global knockout of Epac2 gene expression leads to beta-cell decompensation that is measurable as defective glucose-stimulated insulin secretion in mice. The Commentary concerns findings published by the laboratory of Dr. Mehboob A. Hussain at Johns Hopkins University School of Medicine (Song et al., Diabetes, 2013).
Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.
Molecular Endocrinology 2013
The Holz laboratory collaborated with the laboratories of Dr. Friedrich W. Herberg (Kassel, Germany) and Xiaodong Cheng (Galveston, TX) in order to demonstrate that the fatty acid amide receptor GPR119 stimulates proglucagon gene expression, a necessary first step in GLP-1 biosynthesis. In this study, a new 6-Bn-cAMP-AM analog developed by the BIOLOG Life Sci. Inst. (Bremen, Germany) was also demonstrated to be a selective activator of proglucagon gene expression under the control of RII alpha/beta regulatory subunits of PKA.
Carbon dioxide/bicarbonate and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.
Journal of Biological Chemistry 2013
Soluble adenylyl cyclase (sAC) expressed in pancreatic beta cells can generate cAMP in response to an elevation of blood glucose concentration. The glucose-dependence of sAC activity is explained by its coordinate activation in response to glucose-derived metabolic coupling factors (bicarbonate ion, calcium, ATP). We also find that sAC is an intermediary linking beta-cell glucose metabolism to islet insulin secretion. This paper constituted a collaboration of the Holz laboratory with the laboratories of Drs. Lonny Levin, Jochen Buck, and Geoffrey W.G. Sharp of Cornell University.
Leptin-stimulated K-ATP channel trafficking: a new paradigm for beta-cell stimulus-secretion coupling?
Islets 2013
Park et al. (PNAS 2013) find that leptin stimulates AMPK in order to promote K-ATP channel trafficking from cytosolic vesicles to the plasma membrane of beta cells. Such findings provide an unexpected explanation for the earlier report of Kieffer et al. (Diabetes 1997) demonstrating increased K-ATP channel current and reduced insulin secretion in response to leptin. Conceivably, K-ATP channel trafficking can operate in a reverse mode in order to promote depolarization-induced insulin secretion. For example, high concentrations of glucose may suppress AMPK activity, thereby reducing K-ATP channel density and current in the plasma membrane.
Role of phospholipase C-epsilon in physiological phosphoinositide signaling networks, Cellular Signalling 2012
This review concerning PLC-epsilon was a collaboration of Drs. Alan V. Smrcka, Joan Heller Brown, and George G. Holz. Summarized are current concepts regarding how Epac signals through Rap in order to control PLC-epsilon activity, thereby influencing Ca2+ handling, excitation-contraction coupling, and exocytosis in various cell types.
cAMP Sensor Epac and Gastrointestinal Function, Physiology of the Gastrointestinal Tract, Fifth Edition 2012
Summarized in this handbook chapter are the surprisingly diverse roles Epac proteins play in gastrointestinal function. The work was a collaboration of the Holz laboratory with Dr. Xiaodong Cheng of the University of Texas Medical Branch in Galveston, TX.
Isoform-specific antagonists of exchange proteins directly activated by cAMP, Proceedings of the National Academy of Sciences 2012
A major breakthrough for the field of signal transduction research was the discovery by Dr. Xiaodong Cheng of small molecule compounds (ESI-05, ESI-07) that specifically inhibit Epac2 while leaving Epac1 and PKA unaffected. The specificity of ESI-05 and ESI-07 was validated in FRET-based assays of Epac or PKA activation, as performed in the Holz laboratory by Drs. Oleg G. Chepurny and Colin A. Leech.
Phospholipase C-epsilon links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans, Islets 2011
This report provided the first evidence that a novel Epac2 and Rap1 –regulated PLC-epsilon mediates the action of cAMP to potentiate glucose-stimulated insulin secretion from mouse islets. Consistent with this concept, the insulin secretagogue action of an Epac activator (8-pCPT-2'-O-Me-cAMP-AM) was found to be diminished in islets of Epac2 and PLC-epsilon KO mice. The study was a collaboration of the Holz laboratory with Dr. Youming Lu who provided the Epac2 KO mice, and Dr. Alan V. Smrcka who provided the PLC-epsilon KO mice.
Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic beta cells, Progress in Biophysics and Molecular Biology 2011
This review provided an update concerning the molecular basis for incretin hormone action, as it pertains to insulin secretion under the control of GLP-1. New findings reported in this review included the discovery of Dr. Igor Dzhura that an Epac activator (8-pCPT-2 '-O-Me-cAMP-AM) initiated electrical "bursting" activity in mouse islets. This bursting activity was comprised of action potentials, and it occurred in synchrony with oscillations of cytosolic [Ca2+] that are known to "trigger" pulsatile insulin secretion.
PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans, American Journal of Physiology 2010
This paper established the efficacy of Epac activator 8-pCPT-2 '-O-Me-cAMP-AM as a stimulator of insulin secretion from human pancreatic islets. Surprisingly, protein kinase A (PKA) activity was found to be permissive in order for the Epac activator to exert its effect. Based on this finding, our view is that Epac participates in beta-cell stimulus-secretion coupling at an "early" step upstream of PKA-dependent secretory granule exocytosis. For example, our studies demonstrate that Epac facilitates glucose-dependent K-ATP channel closure, Ca2+ influx, and Ca2+ mobilization.
Facilitation of beta-cell K-ATP channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac, Islets 2010
Clinical studies demonstrate that there is an increased risk of hypoglycemia in patients administered a sulfonylurea and a GLP-1 receptor agonist. Our 2010 paper published in Islets provided evidence that this clinical observation can be explained by the synergistic interaction of sulfonylureas and GLP-1 receptor agonists to promote beta-cell K-ATP channel closure.
Epac2-dependent mobilization of intracellular Ca2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta cells of phospholipase C-epsilon knockout mice, Journal of Physiology 2010
Epac2 is an activator of the small GTPase Rap1, and Rap1 is know to participate in the stimulation of insulin secretion by cAMP-elevating agents such as GLP-1. This 2010 paper provided the first evidence that the Ca2+ dependent exocytosis of insulin might be stimulated as a consequence of the Epac2 and Rap1 mediated activation of a novel phosphoinositide-specific phospholipase C-epsilon. The study was a collaboration of the Holz laboratory with the laboratory of Dr. Alan V. Smrcka of the University of Rochester School of Medicine.
Epac2-dependent Rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1, Vitamins and Hormones 2010
This review summarized current concepts regarding the relative contributions of Epac2 and PKA to the control of islet insulin secretion by GLP-1 receptor agonists. An overview was provided concerning which steps of beta-cell stimulus-secretion coupling are under the control of Epac2 and/or PKA.
Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM, The Journal of Biological Chemistry 2009
Soon after the Holz laboratory moved from NYU School of Medicine to SUNY Upstate Medical University, we collaborated with the BIOLOG Life Science Institute in order to demonstrate the potent insulin secretagogue action of a novel AM-ester of an Epac-selective cAMP analog (ESCA). Such AM-esters of ESCAs are powerful new tools with which to study Epac signal transduction since these compounds have especially high membrane permeability.
Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM, Islets 2009
Working with Dr. Grant G. Kelley of SUNY Upstate, the Holz laboratory was the first to document that the AM-ester of 8-pCPT-2 '-O-Me-cAMP exerted a powerful stimulatory action in mouse islets to potentiate first and second phase glucose-stimulated insulin secretion (GSIS). These findings resolved a long-standing discrepancy in the literature in which the non-AM ester of this Epac activator was reported to either stimulate, or not stimulate, islet insulin secretion.
Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells, PLoS One 2009
This collaborative study of the Holz (SUNY), Prentki (University of Montreal), and Heart (MBL) labs re-examined whether GLP-1 renders beta-cells "glucose competent" by upregulating oxidative glucose metabolism in the beta cells. Surprisingly, and in contrast to findings of Tsuboi et al. 2003 for insulin-secreting MIN6 cells, no such action of GLP-1 was measurable in isolated human or mouse islets.
Role of the cAMP sensor Epac as a determinant of K-ATP channel ATP-sensitivity in human pancreatic beta cells and rat INS-1 cells, Journal of Physiology 2008
This paper was the first to demonstrate that an Epac-selective cAMP analog has the capacity to render beta-cell K-ATP channels more sensitive to the inhibitory action of ATP. This finding provides one possible explanation for how cAMP-elevating hormone GLP-1 acts as a beta-cell glucose sensitizer to enhance insulin secretion.
Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells, Biochemical and Biophysical Research Communications 2008
Reported in this paper are new findings concerning the role of adenylate kinases as intermediaries linking intracellular glucose metabolism to the closure of K-ATP channels in human beta cells.
Epac-selective cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors, Cellular Signalling 2008
This review constitutes a collaboration of the Holz lab with Dr. Frank Schwede of the BIOLOG Life Science Institute. Summarized is an account of research that led to the generation of Epac-selective cAMP analogs (ESCAs). Also summarized are the structural and pharmacological properties of these ESCAs.
Synchronizing Ca2+ and cAMP oscillations in pancreatic beta cells: a role for glucose metabolism and GLP-1 receptors? American Journal of Physiology, Cell Physiology 2008
This commentary provides a summary of our understanding as to how beta-cell glucose metabolism and GLP-1 signal transduction interact to generate oscillations of Ca2+ and cAMP that are in-phase, and that stimulate pulsatile insulin secretion. The paper represents a collaboration of the Holz lab with Dr. Emma Heart of the Marine Biological Laboratory, Woods Hole, MA.
A novel cyclic adenosine monophosphate-responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein-coupled receptor drug discovery efforts, Journal of Biomolecular Screening 2007
This paper describes the invention of a luciferase reporter that is cAMP responsive, and that is useful for screening of cell lines that express G protein-coupled receptors. New ligands that activate these receptors can be identified, or ligands with known structures can be evaluated in order to determine their efficacies or potencies.
Cell physiology of cAMP sensor Epac, The Journal of Physiology Topical Review 2006
This Topical review highlights the emerging role of cAMP sensor Epac as a central player in multiple aspects of cell physiology. The novel pharmacological properties and physiological actions of Epac-selective cAMP analogs (ESCAs) are also updated.
Simultaneous Optical Measurements of Cytosolic Ca2+ and cAMP in Single Cells, Science's STKE 2006
Our collaboration with the laboratory of Dr. Michael W. Roe at the University of Chicago has generated this ground-breaking technology that allows for the very first time, the simultaneous digital imaging of cAMP and calcium concentrations in single living cells. The detailed protocols described here are an extension of the prior study of the Roe, Lohse, and Holz labs (Landa et al. 2005, see below).
cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic β cells and rat INS-1 cells, Journal of Physiology 2006
This research paper describes a novel form of ion channel modulation in which the activity of pancreatic beta cell ATP-sensitive potassium channels is shown to be be inhibited by Epac-selective cAMP analogs. The significance of this finding is that it establishes Epac, a cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF), to be a likely target for pharmacological intervention in the treatment of type 2 diabetes mellitus.
Diabetes Outfoxed by GLP-1?, Science's STKE 2005
This perspective published originally at Science magazine's STKE web site provides our view of how GLP-1 influences pancreatic beta cell growth and differentiation.
A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic β cells, Journal of Physiology 2005
This research paper is the first to establish the phenomenon of Second Messenger Coincidence Detection as a key cellular signaling event underlying the ability of a GLP-1 receptor agonist (Exendin-4, also known as Byetta) to stimulate pancreatic beta cell function.
Interplay of Ca2+ and cAMP Signaling in the Insulin-secreting MIN6 β-Cell Line, Journal of Biological Chemistry 2005
This research paper is the first to demonstrate that a newly-developed Epac-based FRET reporter can be activated as a consequence of GLP-1 receptor stimulation in pancreatic beta cells. The significance of this finding is that it establishes the cAMP-binding domain of Epac to be sensitive to the increase of cytosolic cAMP concentration that results upon stimulation of beta cells with Exendin-4. This report is an outgrowth of collaborative studies with the laboratory of Dr. Michael Roe of the University of Chicago.
New Insights Concerning the Glucose-dependent Insulin Secretagogue Action of Glucagon-like Peptide-1 in Pancreatic β-Cells, Hormone and Metabolic Research 2004
This review summarizes our view of how GLP-1 and glucose metabolism interact to stimulate the secretion of insulin from pancreatic beta cells.
Epac: A New cAMP-Binding Protein in Support of Glucagon-Like Peptide-1 Receptor-Mediated Signal Transduction in the Pancreatic β-Cell, Diabetes 2004
This perspective highlights the potential role of cAMP-binding protein Epac as a determinant of GLP-1 signal transduction in the pancreatic beta cell.
Glucagon-Like Peptide-1 Synthetic Analogs: New Therapeutic Agents for Use in the Treatment of Diabetes Mellitus, Current Medicinal Chemistry 2003
This review summarizes current efforts directed at the generation of GLP-1 analogs that have an extended duration of action and which are useful for treatment of type 2 diabetes mellitus.
Epac-selective cAMP Analog 8-pCPT-2'-O-Me-cAMP as a Stimulus for Ca2+-induced Ca2+ Release and Exocytosis in Pancreatic β-Cells, Journal of Biological Chemistry 2003
This paper describes the pharmacological properties of a newly developed cAMP analog that activates Epac and which stimulates calcium signaling and exocytosis in pancreatic beta cells.
Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 β-cells, Biochemical Journal 2003
This paper describes collaborative studies with the laboratory of Dr. G. Rutter in which stimulatory effects of GLP-1 on mitochondrial ATP production were documented.
Amplification of exocytosis by Ca2+-induced Ca2+ release in INS-1 pancreatic β cells, Journal of Physiology 2003
This paper was the first to demonstrate that GLP-1 receptor agonist Exendin-4 stimulates exocytosis by mobilizing an intracellular source of calcium.
Exendin-4 as a Stimulator of Rat Insulin I Gene Promoter Activity via bZIP/CRE Interactions Sensitive to Serine/Threonine Protein Kinase Inhibitor Ro 31-8220, Endocrinology 2002
This paper describes our studies of regulatory elements in the rat insulin 1 gene promoter that mediate stimulatory actions of Exendin-4 on insulin gene expression.
Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic β-cell lines for use in transplantation, Cell and Tissue Research 2002
This paper describes a strategy for the generation of insulin-secreting cell lines that overexpress GLP-1 receptors and which exhibit robust glucose-dependent insulin gene expression.
cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic β-cells, Journal of Physiology 2001
This paper was the first to establish a link between GLP-1 receptors, activation of Epac, and the mobilization of intracellular calcium.
Glucagon-Like Peptide 1 Stimulates Insulin Gene Promoter Activity by Protein Kinase A-Independent Activation of the Rat Insulin I Gene cAMP Response Element, Diabetes 2000
This paper was the first to demonstrate that protein kinase A-independent signaling pathways mediate stimulatory actions of GLP-1 at the insulin gene promoter.
cAMP-dependent Mobilization of Intracellular Ca2+ Stores by Activation of Ryanodine Receptors in Pancreatic β-Cells, Journal of Biological Chemistry 1999
This paper established a link between GLP-1, cAMP production, and the release of calcium from intracellular calcium stores in beta-cells.
Leptin Suppression of Insulin Secretion and Gene Expression in Human Pancreatic Islets: Implications for the Development of Adipogenic Diabetes Mellitus, Journal of Clinical Endocrinology and Metabolism 1999
This study examined the action of Leptin - a newly described "obesity hormone" that was found to inhibit pancreatic beta cell insulin gene expression. The findings were generated at Massachusetts General Hospital through the collaboration of Dr. Holz with Dr. Jochen Seufert while working in the laboratory of Dr. Joel F. Habener.
Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K+ Channels in Pancreatic β-Cells, Diabetes 1997
This was the first published study to demonstrate that the "obesity hormone" Leptin stimulates the function of ATP-sensitive potassium channels. Leptin receptors on pancreatic beta cells were characterized, and the inhibitory action of leptin on beta cell insulin secretion was established. The findings were generated through a collaboration of Dr. Holz with Dr. Timothy Kieffer while working in the laboratory of Dr. Joel F. Habener at Massachusetts General Hospital.
Signal transduction of PACAP and GLP-1 in pancreatic beta cells, Annals of the New York Academy of Sciences 1996
This review summarized our laboratory's findings concerning the cAMP-mediated actions of PACAP and GLP-1 to activate non-selective cation channels in pancreatic beta cells. These findings were presented by Drs. George Holz and Colin Leech at a meeting of the New York Academy of Sciences in New Orleans, LA.
Activation of a cAMP-regulated Ca2+-Sgnaling Pathway in Pancreatic β-Cells by the Insulinotropic Hormone Glucagon-like Peptide-1, Journal of Biological Chemistry 1995
This paper established a role for non-selective cation channels as targets of cAMP signaling in pancreatic beta cells. In addition to its inhibitory effect at ATP-sensitive potassium channels, GLP-1 promotes sodium-dependent depolarization of beta cells, thereby increasing levels of cytosolic calcium. The study was a collaboration with Dr. Colin A. Leech of Massachusetts General Hospital while working in the laboratory of Dr. Joel F. Habener.
Pituitary Adenylate Cyclase-Activating Polypeptide Induces the Voltage-Independent Activation of Inward Membrane Currents and Elevation of Intracellular Calcium in HIT-T15 Insulinoma Cells, Endocrinology 1995
This paper describes the stimulatory action of the neuropeptide PACAP on beta cell function. PACAP is structurally-related to GLP-1, and the PACAP receptor bears resemblence to the GLP-1 receptor. The study was a collaboration with Dr. Colin A. Leech of Massachusetts General Hospital while working in the laboratory of Dr. Joel F. Habener.
Application of patch clamp methods to the study of calcium currents and calcium channels, Methods in Cell Biology 1994
This review concerning patch clamp electrophysiology was published in Volume 40 pgs. 135-151 of Methods in Cell Biology for the issue "A Practical Guide to the Study of Calcium in Living Cells".
Voltage-Independent Calcium Channels Mediate Slow Oscillations of Cytosolic Calcium That Are Glucose Dependent in Pancreatic β-Cells, Endocrinology 1994
This study demonstrated that spontaneous oscillations of intracellular calcium concentration can occur in beta cells, a phenomenon not necessarily linked to membrane depolarization. The findings are of interest in view of the role of intracellular calcium stores as determinants of beta cell stimulus-secretion coupling and regulated gene expression. The study was a collaboration with Dr. Colin A. Leech of Massachusetts General Hospital while working in the laboratory of Dr. Joel F. Habener.
Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37), Nature 1993
This letter to Nature was the first published study in support of the Glucose Competence Concept. Our view is that GLP-1 restores the ability of compromised beta cells to metabolize glucose and to secrete insulin. The induction of glucose competence is measurable as the synergistic interaction of GLP-1 and glucose to inhibit ATP-sensitive potassium channels in beta cells. The study was a collaboration with Dr. Willem M. Khutreiber of Massachusetts General Hospital while working in the laboratory of Dr. Joel F. Habener.
Signal transduction crosstalk in the endocrine system: pancreatic β-cells and the glucose competence concept, Trends In Biochemical Sciences 1992
This review concerning the Glucose Competence Concept was published in a thematic issue of Trends in Biochemical Sciences. This issue signified the emergence of Signal Transduction as a dominant theme in contemporary biology. It was also the first formal publication generated by Dr. Holz as a consequence of his collaboration with Dr. Joel F. Habener, co-discoverer of GLP-1.
G Proteins Couple α-Adrenergic and GABAb Receptors to Inhibition of Peptide Secretion from Peripheral Sensory Neurons, Journal of Neuroscience 1989
This research report is the culmination of postdoctoral studies performed by Dr. Holz while working in the laboratory of Dr. Kathleen Dunlap at Tufts University School of Medicine. The findings demonstrate that alpha-adrenergic receptors, GABA-B receptors, Pertussis Toxin-Sensitive G proteins, and Voltage-Dependent Calcium Channels constitute a "signaling module" which when activated, generates presynaptic inhibition of neuropeptide secretion from peripheral sensory neurons.
Characterization of the Electrically Evoked Release of Substance P from Dorsal Root Ganglion Neurons: Methods and Dihydropyridine Sensitivity, Journal of Neuroscience 1988
The role of L-type and N-type Voltage-Dependent Calcium Channels as determinants of neuropeptide secretion was first established in this study examining the exocytosis of Substance P from peripheral sensory neurons. This is the first study to demonstrate that the electrically-evoked release of a neuropeptide results from depolarization-induced activation of omega-conotoxin GVIA-sensitive N-type Calcium channels.
G proteins as regulators of ion channel function, Trends In Neuroscience 1987
This review provided the impetus for numerous studies examining the role of heterotrimeric G proteins as signaling intermediaries linking G protein-coupled receptors to the modulation of Calcium and Potassium channels in excitable cells.
Modifying channel function, Nature 1986 News and Views
This is the News and Views article which accompanied our 1986 report in Nature concering G protein regulation of voltage-dependent calcium channels.
GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels, Nature 1986
This is the paper that established a link between activation of G proteins and the inhibition of voltage-dependent calcium channels. It was the most highly cited paper in the field of Neuroscience for the year 1986 according to the ISI. Publication of this study was facilitated by the generosity of Dr. Ronald D. Sekura of the NIH who provided Dr. Holz purified preparations of Bordetella pertussis toxin, which at that time were not commercially available.
Serotonin Decreases the Duration of Action Potentials Recorded from Tetraethylammonium-Treated Bullfrog Dorsal Root Ganglion Cells, Journal of Neuroscience 1986
This research report summarizes the Ph.D. studies of Dr. Holz performed while working in the laboratory of Dr. Edmund G. Anderson, Chairman of Pharmacology at the University of Illinois in Chicago. The role of serotonin receptors in the generation of presynaptic inhibition was investigated in electrophysiological studies of primary sensory neurons.


text: Old Town Hosts Oktoberfest Friday, October 04, 2013 7:44 a.m. EDT Oktoberfest USA in La Crosse. (courtesy of Facebook). Old Town in Lansing will be bustling with people and music this weekend. The 8th annual Oktoberfest begins tonight and continues tomorrow. Organizers say the German heritage celebration is a 21 and up event. Comments


text: Don't tell the Cardinals that OLG Alan Faneca is over the hill. The way we hear it, the perennial Pro Bowler is more than pulling his weight in the desert. "He still moves pretty well," one team insider said of Faneca, a free-agent addition this offseason after being released by the Jets. "He's still very good at pulling and finding defenders in space. He just has a really good feel for picking up guys at the second level. They thought he still had something left when they signed him, and they've been pretty satisfied." Faneca also has been an effective decoy. "Sometimes they'll pull him and then run in the other direction, so that's another good thing he's doing," the insider said. As for Faneca's pass protection, our sources believe he's been holding his own. "I haven't seen any major breakdowns," the insider said. "They have much bigger concerns elsewhere on the line."


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here is a site that I like http://perso.wanadoo.fr/marc.esprit/. this guy has a huge restore project .
have a special look to "celestin". This kind of single cylindered tractors were very popular in europe until the 50's. the "Vierzon French Society" was bought by CASE in the early 60's and the production of these machines stopped.
No "harvest show" can happend in france without at least one Vierzon or Lanz tractor to power the treshing machine. Their noise, especialy at idle is so impressive! Well, starting is another adventure.
of course the site is in french, but there is a lot of pictures...


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LOUISVILLE, KY. (WDRB) -- It would be nice to select all your players out of the blue-chip, can't-miss catalog. In fact, the best college basketball programs today are pretty much able to do just that.But every once in a while, even for those programs, somebody sneaks through that isn't supposed to.Saturday in U of L's 69-66 win over Illinois State in the KFC Yum! Center, the two guys the University of Louisville basketball team absolutely could not do without were two guys it almost did without -- voluntarily.Russ Smith had 24 points and made offense happen when the Cardinals could find no other way to do it. After Smith's freshman season, U of L coach Rick Pitino had told them there was little future for him in Louisville, and after a long talk with his father, decided they'd give it one more year and see what happened.A Final Four happened.This past summer, Pitino gave Van Treese the "you need to go somewhere if you want playing time" speech. Montrezl Harrell showed up, and Van Treese was out, even took a couple of visits. Then Rakeem Buckles decided to head back home to Miami to rehabilitate his knee injury, and Van Treese came back eagerly at Pitino's invitation.On Saturday, he delivered enough defense and rebounding in the absence of Gorgui Dieng to help U of L avoid the kind of home-court loss that sends the pundits wagging and leaves team confidence flagging.Instead, Van Treese came into the game early and seemed to be the spark the team needed. He played 34 minutes. Smith played 35 minutes. No other Cardinals played more than those two.
"It just felt good," Van Treese said. "I've been here a long time and never really felt like I was contributing the way I could, because of injuries or whatever. So it's good to be in a position to be able to help the team. The team needs it right now and I want to work really hard to make sure I come through."You have to like it when the question goes from, "What am I going to do with this guy?" to "What would we do without him?""What I wanted for Stephan was to go to Bellarmine and play 38 minutes (a game) to get his confidence back in his game, then come back for your last year with us," Pitino said. "But get on the court and start playing because I didn't think he would play a lot with us. Then he started visiting Illinois and other places. I said that is absurd and ridiculous. I called him back and said that I have been reading all this crap, it is time to come back home. He said I am so relieved coach, I will be back immediately. I just wanted what was best for him and it is funny how things turn out."Here's how it has turned out for Van Treese. He hung tough against Mason Plumlee and Duke. And against Illinois State, became a player Pitino didn't want to take off the court.
"Stephan is a warrior. . . ." Pitino said. "We watch Kenneth Faried tapes and his technique every day. Stephan has looked at it. Stephan wasn't a good rebounder, because he stays in his plane. But he's been watching Faried and the key to why Faried is so great is not only does he block out at the defensive end, but he watches the ball the entire time, so he knows how to chase it down and tip it to himself. We're watching and trying to get that technique and Chane (Behanan) and Stephan have been getting better at that. He gave us a big lift when we needed it. It's going to be a fight. We're not going to have an easy game, but it's going to be a fight until we get our shot blocker back. But Stephan did a fabulous job."
As for Russ Smith, well, he's a study in contradictions."Russ nearly lost us the game by losing his man (at the buzzer)," PItino said. "But he single-handedly won the game. ... You know Russ is a very special basketball player. He does things you would never think of. He made a move with the game on the line that possibly we could lose, and he goes behind his back to make the move? You wouldn't even think of that. That is what makes him so special. He has absolutely no fear of anything and you have to have that on a basketball team. It doesn't matter if he is playing in the Bahamas or here. Some guys get tight at home, not Russ."This would've been some conversation to overhear. Pitino said Gorgui Dieng -- who himself was the lesser heralded player in a recruiting race to land Fab Melo -- engaged Pitino in a philosophical discussion last week."Gorgui said something to me the other day," Pitino said. "He said things happen for a reason. I said Gorgui, 'That is not true and I don't believe in any of that stuff. I said things don't happen for a reason. You fell down and fractured your wrist. That is not the Lord saying, 'I am going to take Gorgui out so Louisville gets more experience and drive Coach Pitino up the wall with a straight jacket.'"Maybe not. But basketball works in mysterious ways. Van Treese and Smith leading the Cardinals in minutes played on Saturday is proof.NOTES: The Cards got a combined zero points from Wayne Blackshear, Kevin Ware and Luke Hancock. The trio went 0-for-11 from the field, though they did combine for 10 rebounds. At a spot most teams count on for significant scoring, it's a problem."We're struggling a little bit right now at the three spot, we really are," Pitino said. ". . . We just have to keep staying positive, but we have to get better."-- Pitino poked a little fun at himself and his tendency to build up opponents. He was talking about how good he believes Illinois State to be, saying, "They have one of the great young coaches in the game," and comparing Dan Muller to Butler's Brad Stevens. Then Pitino said this:"You guys don't believe me because I tell you how great bad teams are, but this team, the Missouri Valley Conference, is terrific."-- Pitino said Chane Behanan is going to have to change his free-throw form. He praised Behanan's overall play after the sophomore contributed 15 points (on 7-of-8 shooting) and nine rebounds, but made just one of seven free throws, including a couple of crucial late misses."I told Chane if he doesn't change his form, it's not going in," PItino said. "I actually was more pleased with his last two, even though they didn't go in."
Copyright 2012 WDRB News. All Rights Reserved.
624 W. Muhammad Ali BlvdLouisville, KY 40203


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The U.S. Marshals Service Northern Iowa Fugitive Task Force is seeking the public's assistance in locating Robert Jon Galvin. Galvin, 28, is 6'4" tall, 220 lbs and is wanted by the Iowa Department of Corrections for probation violation, operating while intoxicated, domestic abuse assault 2nd offense, and burglary 3rd degree. Galvin has numerous tattoos. The last known address for Galvin was South Sioux City, NE.
Anyone having information on the whereabouts of Galvin or information leading to the arrest of Galvin should contact the U.S. Marshal Service in Sioux City, IA at (712) 252-0211 or email@example.com. Callers can remain anonymous and the information provided will remain confidential. The U.S. Marshal Service routinely works with local law enforcement agencies in locating and arresting fugitives. For more information on the U.S. Marshals visit www.usmarshals.gov
Siouxland News
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text:
Expired Property Listing
This property is disabled.
"Cottage on the Green" at Tan Tar A! Indoor Waterpark! in Osage Beach
- bedrooms 3
- baths 2
- sleeps 12
- pool yes
- hot tub no
- pets allowed no
- type House
- community TanTarA Estates
rates (USD)
/ night
vacation rental description
This property is geared to "FAMILIES" and "MATURE ADULTS Only".
You must be at least 30 years of age to rent this property.
This is our home at Lake of the Ozarks. It is located in Tan Tar A Estates. It sits right on the #4 green of Hidden Lakes Golf Course. This is a 3 bedroom 2 bath home.
OR you may rent as a 1 bedroom suite.
The home has been remodeled and beautifully decorated. Located on a cul de sac and just a short drive from one of two community pools. Lake access and most of Tan-Tar-A Resort amenities are available. The home can easily house more than one family with several children. It has one master bedroom with two queen beds, one bedroom with two queen beds and a third bedroom with 2 full size beds. The second and third bedroom share a bathroom.
Our home has a full kitchen with stove, refrigerator and dishwasher. Kitchen utensils, pots, pans, and dishes are all furnished.
There are two covered porches and one uncovered patio. The large covered patio off the living room has a table, chairs and large gas grill.
The living room has an HD flat screen TV with DVD player. All bedrooms have a TV. The third bedroom has Super Nintendo and many board games for your enjoyment. There is parking for 3 cars. There is a electric fireplace.
Electric Fireplace, and wireless internet!
This is a non-smoking and no pets home!
If the house is left damaged, smoked in, has items missing, or excessively dirty, an additional fee will be charged to your credit card.
house rental amenities
Some Tan Tar A Resort amenities can be included in your vacation experience (for extra $$). Here is what the resort has to offer: Miniature golf, bowling, arcade, fast food restaurants, two five star restaurants, golf cart rentals, indoor waterpark, horseback riding, spa, boat rental, jet ski rentals, parasailing, Tropic Island Cruises.
There are two pools available for your use (seasonal) free of charge.
The home sits on the #4 green of Hidden Lakes Golf Course which is a public 9 hole course nestled in the estates. Less than 3 miles away you can find 2 more public golf courses that each have an 18 hole golf course for your enjoyment.
activities and attractions in Osage Beach Missouri
Very close by you will find fine dining, fast food, grocery stores, antique shops, shopping malls, live theatre, and cinemas. Still need more. . .Osage Beach offers fun for the entire family with state parks, hiking, caves, picnic areas, natural springs, and the very best Missouri has to offer. Big Surf Water Park is only 5 minutes from your front door with a days worth of fun for the entire family!
TanTarA Resort was voted one of the best places to visit by Midwest Living Magazine.
vacation rental rates
May 23 - Sept 8 Rental Rate is $299/night plus tax
Sept 9 - May 21 Rental Rate is $199/night plus tax
OR just rent as a suite for the following rates.
May 23 - Sept 8 Rental Rate is $169/night plus tax
Sept 9 - May 21 Rental Rate is $99/night plus tax
We do not provide daily housekeeping however cleaning is available for an additional charge. Some guests choose a mid-week clean during their weekly vacation.
Towel, Trash and Tidy Package
- Make bed with existing linen
- Provide clean towels
- Take out trash
- Vacuum
- Replenish Paper Towels, Toilet Paper, Soap and Shampoo
Cost: $44 per day
Full Clean Package
Suite will be fully cleaned to quality standards with fresh linen, Paper Towels, Toilet Paper, Soap and Shampoo
Cost: $74 per day
Tax Rate: 8.475%
MC, Visa, or Discover
A deposit via credit card is required to confirm a reservation.
Cancellation Policy: No refund of deposit if cancellation is within 30 days of reservation. If cancellation is prior to 30 days, a refund less a $25.00 service fee will apply. If cancellation is within one week of reservation, you will be responsible for the entire rental amount.


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After a week without games, the Final Four matchups have been sliced and diced in almost every way. In the first game between rivals Louisville and Kentucky, the Cardinals' stout defense hopes to disrupt a more talented Kentucky team with AP player of the year Anthony Davis. Sports Illustrated's Luke Winn has an excellent graphic analysis of each Final Four team, and he highlights the offensive versatility of Davis:
According to SI's charting, Davis has 47 offensive possessions in the NCAA tournament, and he's averaging 1.191 PPP, down from his season-long figure of 1.358. His ability to alter his offensive identity from game-to-game, though, has only gotten better.
The ways Davis tries to score in the tourney have varied widely. Against Baylor in the Elite Eight, Davis had 13 possessions and was heavy on spot-up jumpers (four) and lobs (four). He posted up just once.
Kentucky coach John Calipari insists that Davis will be a three at the next level, and much of Winn's analysis bolsters that notion and reiterates his outside skills on the offensive end of the floor.
The second game will feature a strength-on-weakness matchup when it comes to turnovers, as Ohio State guard Aaron Craft is one of the best in the country at forcing them and Kansas' Tyshawn Taylor has been one of the most turnover-prone guards in the tournament so far. Winn has two telling graphs that highlight these strengths and weaknesses, and he also drops this stat on Craft's defensive prowess:
This is my current favorite CraftFact: In the NCAA tournament, he's accounted for 40.20 percent of Ohio State's total turnover production. That includes 13 credited steals, 5.5 uncredited turnovers, one charge taken and one moving-screen foul drawn.
While the main focus will be on the inside clash between the All-Americans, Jared Sullinger of OSU and Thomas Robinson of KU, the second game will likely be won or lost in the backcourt.
For coverage of the Louisville Cardinals, stop by Card Chronicle. For more on the Kentucky Wildcats, Louisville's Final Four foe, check out A Sea of Blue. For all news and information regarding the Ohio State Buckeyes, please visit Along The Olentangy. For updates and perspective on the Kansas Jayhawks, head on over to Rock Chalk Talk. For all your 2012 March Madness needs, stay tuned to SB Nation's dedicated NCAA Tournament hub.


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Gloucester Daily Times
---- — Track
Swampscott 44,
Gloucester 41 (boys)
A team needs at minimum 44 points to win a track meet in NEC play and Swampscott came through with a win by the slimmest of margins as Gloucester falls to 1-3 on the year.
"We knew it was going to be a battle today," Gloucester head coach Jeff Destino said. "You never like to lose but I couldn't be happier with the way we competed."
The Fishermen came into the meet undermanned with multiple key contributors nursing injuries or ill. With a team the size of Gloucester's every missing player makes a big impact.
Gloucester had several strong individual performances led by Matt Carpenter in the 600 and Noah Mondello in the mile. Both finished in first place and both qualified for the state meet with times of 1:27.4 and 10:09.5 respectively.
Everest Crawford (1,000m), Jared Marshall (hurdles), and Matt Ciaramitaro (high jump) all took home first place finishes. Destino also praised the work of senior captain Jacob Holscher in the mile, whose time of 4:37.6 was good enough to qualify for the state meet, and freshman Jeremy Meunsaveng, who finished second in the 300.
Swampscott 59,Text ColorSwatch/NoneStrokeStyle/$ID/SolidText ColorSwatch/NoneStrokeStyle/$ID/Solid$ID/NothingText ColorText Color$ID/NothingText ColorText Color Text ColorSwatch/NoneStrokeStyle/$ID/SolidText ColorSwatch/NoneStrokeStyle/$ID/Solid$ID/NothingText ColorText Color$ID/NothingText ColorText Color
Text ColorSwatch/NoneStrokeStyle/$ID/SolidText ColorSwatch/NoneStrokeStyle/$ID/Solid$ID/NothingText ColorText Color$ID/NothingText ColorText ColorGloucester 22 (girls)
Gloucester falls to 2-2 at the hands of a strong Swampscott team.
Liz McCormack led the way for an undermanned Gloucester team, that was fighting injury and illness, with a first place finish in the shot put. Gloucester also got personal bests from Hannah Pastagal in the shot put, Chloe Kenyon in the hurdles, Corinne DeLouise in the 600 and Caity O'Leary in the 300. Head coach Liz Moran also praised the work of Kelly Foster and Melanie MacDonald in the two-mile.
Beverly 5 Gloucester 1
The Fishermen fall to 1-5-1 on the season with the loss to the unbeaten Panthers. Alex Webb scored Gloucester's goal which was the first goal Beverly has allowed in Northeastern Conference play this season.
Boys Basketball
Revere 69, Gloucester 52
The Fishermen (3-7) had a tough second quarter scoring six points and were forced to play catchup the rest of the night against a solid Revere team.
"We had a cold shooting quarter in the second and then we couldn't catch up," Gloucester head coach Bill Cahill said. "Revere got into a rhythm in the second half and when they're hitting their threes they're a good team."
Drew Shairs led the way for Gloucester with 18 points and 12 rebounds, Jason Vizena had 10 points and Austin Davis scored 8.
Hamilton-Wenham 48, Rockport 45
The Vikings (4-3) took a 30-22 lead into the break but went cold from the field in the second half en route to their third straight loss.
Freshman Andrew Waynrynen led the way for Rockport with 19 points on five three pointers. Senior captain Tucker Meredith had 12 points, Sam Knowlton had eight while Jake Rostowski drew praise from head coach Tim St. Laurent for his defense and rebounding off the bench. St. Laurent also praised Mike McCarthy for toughing out an ankle injury.
"I couldn't have been prouder of the way we played," St. Laurent said. "The effort was great, we couldn't have played harder, we just came up a little short."


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Former head of Boston FBI faces federal charges
The former head of the Boston office of the Federal Bureau of Investigation was charged with a federal crime for allegedly having professional contact with the FBI once he retired and went to work for a private investigative technology company.
Kenneth Kaiser, 57, of Hopkinton, is charged with making prohibited post-employment contacts, the U.S. Attorney's office announced Thursday. He could face up to one year in prison and a fine of up to $100,000.
Kaiser worked as head of the Boston FBI between 2003 and 2006. He then went to work as an assistant director for the FBI's Criminal Investigative Division in Washington, D.C. until his retirement in 2009.
Upon his retirement he went to work for LocatePlus, a Boston-based investigative technology and database company. He was hired to conduct an internal investigation into wrongdoings by the company's chief executives and to generate government sales for the company as Director of Government Sales.
It was in those capacities that Kaiser allegedly had " numerous prohibited electronic, telephonic and in-person contacts" with FBI employees regarding the investigation into LocatePlus, according to the U.S. Attorney's office.
He also allegedly contacted FBI employees in an effort to sell LocatePlus' products.
A federal ethics law prohibits senior personnel from making professional contacts with the agency in which they were employed for one year after their end of government service.
Follow Michael Naughton on Twitter @metrobosmike.
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|Sudden Death Syndrome in soybeans shows up in Putnam County
|Thursday, August 22, 2013 12:05 AM
Ag Educator
Putnam County
The following information is condensed from a Purdue fact sheet (Diseases of Soybeans, BP-58-W) on soybean sudden death syndrome (SDS). SDS is showing up in Putnam County fields and the first signs are small, bright, pale green to yellow spotted leaves and then leaf drop. It occurs in wet areas, end rows and/or compacted areas that may enlarge after two-three weeks. Generally, the soybeans upper leaves between the veins will turn yellow and then turn brown and die.
To positively identify SDS, split the soybeans lower stem and taproot and look for a slightly tan to light brown discoloration in infected plants. The pith (central portion of stem) will remain white or slightly cream-colored. SDS infected plants often have light blue patches on the soil line near the taproot's surface which are blue SDS spore masses. SDS is caused by the soilborne fungus Fusarium solani and survives the winter in the crop residue or lives freely in the soil.
The fungus also can survive in cysts of the soybean cyst nematode (SCN) and can withstand wide soil temperature fluctuations (including freezing) and resists desiccation (drying out). As soil temperatures rise in the spring, spores near soybean roots are stimulated to germinate and then infect soybean roots. The fungus may infect roots as early as one week after crop emergence but aboveground symptoms of SDS rarely appear until mid-July, when soybean plants start to flower. Heavy rains during reproductive stages (R3-R6) often are critical for SDS development. Over a period of years, flowing water and cultivation practices may move the spores over large areas, increasing the infected area.
SDS management options are limited. Although soybean varieties less sensitive to SDS have been developed, there are no highly-resistant varieties. While most seed companies have removed highly-susceptible varieties from their inventories, no highly-resistant varieties are available. Fungicides applied in furrow during planting or as seed treatments have only limited effects, and fungicides applied to foliage have no effect on SDS. Management practices may reduce the risk of SDS damage but they will not prevent the disease.
Early planting predisposes soybean to infection due to cool wet soils. Rapid spring soybean growth and dry soils limit the risk of SDS infection and if the SDS fungus is not present, the soybeans will not develop SDS. So growers should plant fields with no history of SDS first and then plant fields where SDS has been a problem later.
Compacted soils impede water percolation and restrict root growth. A heavy rain when soybeans havereached the reproductive stage will saturate compacted areas, which promotes SDS development. Correcting soil compaction and water permeability problems may reduce the risk for SDS. Tile drainage or planting cover crops may improve permeability. In some soils, no-tillage can be beneficial and increase soil water permeability. In other soils, tillage may be necessary for maintaining sufficient vertical water movement. Growers should focus on how to create the best soil drainage to reduce SDS infection.
There does not appear to be a rotation that significantly reduces SDS. Corn does not reduce the incidence and severity of SDS; and severe outbreaks of the disease have occurred even after several years of continuous corn. However, crop rotation does reduce other soybean pathogens. It appears that shifting to a two-year rotation of corn and soybeans (compared to longer rotations) has favored the buildup of SDS populations and other soil-borne soybean pathogens.
Purdue studies have found that when corn is grown in the field, soil-borne soybean pathogen populations may decline but not enough to substantially reduce the problem. Although a two-year C-S rotation may hold soybean cyst nematode (SCN) populations below threshold levels when the SDS population is low, such a rotation appears to be too short to reduce populations of SDS during the year corn is grown.
The combined action of SDS and SCN will damage soybean varieties susceptible to both pathogens. Production practices that maintain SCN at low levels may reduce the risk for SDS and if SCN is present, a management strategy for both pests should be implemented. Including cover crops in the crop rotation, especially cereal rye or oil seed radish may improve soil health, soil diversity and improve soil drainage to lower SCN populations.
Yield reductions due to SDS are dependent on when infections begins and usually the most productive part of the field is affected. Early infections will result in pod abortion, reduced seed number and size. Infections after flowering will not have a significant impact on yield. See http://ohioline.osu.edu/ac-fact/pdf/0044.pdf for more information.


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Possible Traffic Delays at 46th and 47th Street along Monarch Way
Due to steel deliveries for the New Art Building, there may be traffic delays along Monarch Way at the 46th street and 47th street intersections while the trucks are being unloaded. The deliveries are scheduled for June 17th through July 12th.
Posted By: Pamela Kiger
Date: Fri Jul 05 10:39:42 EDT 2013


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Town Square
Swalwell applauds reversal of TSA knives policy
Original post made on Apr 23, 2013
Read the full story here Web Link posted Tuesday, April 23, 2013, 7:39 AM
on Apr 23, 2013 at 9:04 am
More congressional meddling and grandstanding. Let the experts do their jobs, Congressman. The TSA is using science and hard data to balance public safety and the efficient use of travel security resources. Do you seriously think air passengers are going to start attacking one another and their flight crews with nail clippers and swiss army knives? Flight crews naturally want 100% safety and full control over their passengers, but they are working in an airplane, so pen knives have to rank pretty low on the risk list. All TSA search and seizure practices should be balanced against personal rights and objectively analysed for efficacy and efficiency.
on Apr 23, 2013 at 9:36 am
OMG, it's beginning to look like Swalwell is just as crazy as Stark (well, maybe not THAT crazy, but still plenty crazy). Banning pen knives is just ignorant. If they think pen knives are that dangerous, then they better ban those bottles of booze they serve on planes. It's plenty easy to break one of those and have a weapon much more dangerous than a pen knife. Oh, I forgot, most left-wing-loon politicians love their booze.
I suppose the next thing these liberal jackasses will propose, after the Boston bombing, is to ban pressure cookers, nails, ball bearings, black powder, circuit boards (they go all your gadgets), cell phones, back packs, and automobiles.
on Apr 23, 2013 at 9:53 am
Stalwell is just following the Democratic Party line. No data. No science. Just sound bites: ban those knives; ban those guns; ban those plastic bags; ban everything. Solve no real problems: just create more and more useless laws and regulations, then raise taxes through the roof to enforce the useless laws and fund the creation of more useless laws and regulations.


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Allegations that a Coral Gables clinic at the center of a Major League Baseball doping scandal also provided drugs to high school athletes could lead the Miami-Dade school district to consider drug-testing for students involved in extracurricular activities.
School Board member Raquel Regalado wants the district to establish a random drug-testing policy, and board members could approve a cost and feasibility study for such a program next week. Regalado said drug testing is appropriate considering the federal probe into whether Biogenesis of America gave performance-enhancing drugs to student athletes.
"I don't see it as controversial. I think it's responsible," Regalado said. "Whether we're on [the list] or not, it's an issue every district should be talking about."
The Biogenesis scandal has led to lengthy suspensions of multiple pro baseball players, including University of Miami star Ryan Braun and homegrown superstar Alex Rodriguez. With regard to high school athletes, whistleblower and former Biogenesis employee Porter Fischer has said teenagers frequented the clinic in the company of their parents. He met this month with a federal grand jury in Miami-Dade County and has been ordered to turn over clinic documents in his possession.
The Miami Herald has seen a partial list of alleged clients of Biogenesis from October 2011. On it are two local high school ballplayers — from private schools — who are now seniors, and five other players from Miami-Dade and Broward who are now in college.
"I'm very concerned. This [clinic] is less than a mile and a half from Coral Gables Senior High," Regalado said.
Her proposal has the support of the Florida High School Athletic Association, the state's governing body for high school sports. Executive Director Roger Dearing has called for greater attention from school districts to the use of performance-enhancing drugs.
But more importantly, Regalado needs support of a majority of School Board members, who gave her pitch a lukewarm reception Wednesday at a committee meeting. Among their concerns: the potential for racial profiling of black athletes; and funding tests that, when the FHSAA conducted 600 of them in 2007-08, cost $166 a pop.
"My first feeling dealt with the profiling, and also the number of African-American youth who are in these competitive sports and the implication of what might also come about as a result of this testing," said board member Wilbert "Tee' Holloway.
Still, none of Regalado's colleagues said they opposed her proposal. Daniel Tosado, chief of staff for Superintendent Alberto Carvalho, said the conversation about drug testing and awareness is worth having.
Regalado said Miami-Dade Schools last had a drug-testing policy in 1981. She said the School Board approved a pilot drug-testing program in 1997, which was ditched after funding ran out. The FHSAA stopped conducting tests five years ago after a grant ran dry.
Regalado said she's not asking the district to fund the program, which would include all extracurricular activities. She said donors are willing to fund its first year.


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Update: The recent federal black sea bass stock assessment update found black sea bass were no longer overfished or undergoing overfishing. Based on the rebuild status of black sea bass, the South Atlantic Fishery Management Council has proposed to more than double the current annual catch limit. NOAA Fisheries approved this request and it will go into effect Sept. 23, 2013. Learn more about the recent updates to the Atlantic black sea bass fishery.
Gulf State Waters
Atlantic State Waters
Minimum Size Limit
10" total length
13" total length
Daily Bag Limit
100 pounds per person
5 fish per person
Gear Requirements:
Black sea bass, which are often called "rock bass," prefer natural, hard bottom areas and limestone ledges. While they are most commonly caught along Florida's central and northern coasts, they sometimes venture to south Florida waters during cold winters. Mature black sea bass generally prefer depths of 20 to 80 feet but juveniles can also be caught in shallower water over sea grass and near jetties and reefs. Like many other members of the grouper family, black sea bass prey on fish, squid, shrimp and other crustaceans.
Anglers commonly catch black sea bass incidentally while bottom fishing for grouper or snapper. While smaller than most other members of the family, black sea bass are aggressive and fun to catch, especially if you scale back to lighter tackle. Light to medium weight spinning or bait casting tackle with 10 to 20 pound test line is sufficient. At times (especially during the winter months) black sea bass are so hungry and aggressive that they will hold on to your lead all the way to the surface or the bottom of your cooler. Good baits for black sea bass include squid, shrimp or cut bait, or jigs tipped with squid. As a food fish, black sea bass are excellent and known for their firm white flesh and mild flavor.
Florida Rule
Gulf Federal Waters Rules
Atlantic Federal Waters Rules
Atlantic federal waters
NOAA Fisheries Service determined that the 2010-2011 recreational annual catch limit (ACL) of 409,000 pounds for black sea bass (set in Amendment 17B) was reached before the end of the fishing year. As an accountability measure, the recreational fishery for black sea bass in federal waters of the South Atlantic closed Feb. 12, 2011, and reopened June 1, 2011. This action was intended to prevent overfishing of black sea bass.
When final recreational landings for the 2010-2011 fishing year became available, NOAA Fisheries Service determined that the ACL was exceeded by 67,253 pounds. In response, NOAA Fisheries Service reduced the 2011-2012 recreational ACL from 409,000 pounds to 341,747 pounds to account for the 67,253 pound overage.
NOAA Fisheries Service has determined that the 2011-2012 recreational annual catch limit has been reached. As a result the recreational sector for black sea bass in federal waters of the south Atlantic closed October 17, 2011 and reopened June 1, 2012.
In an effort to keep anglers from exceeding the annual catch limit for black sea bass in future fishing years, NOAA Fisheries Service approved regulations that reduce the recreational bag limit for black sea bass from 15 to five per harvester per day in federal waters of the Atlantic. This bag limit reduction took effect June 22, 2011, in Atlantic federal waters only.
Charter and headboats that hold federal snapper-grouper permits are required to abide by these federal rules, even in state waters. The recreational bag limit for black sea bass harvested in state waters of the Atlantic will remain at 15 per harvester per day for anglers who are not fishing from federally permitted vessels. State waters extend three nautical miles from shore into the Atlantic.
On July 1, 2012, the recreational minimum size limit was increased from 12 inches total length to 13 inches total length in federal waters.
The recreational harvest of black sea bass in Atlantic federal waters closed Sept. 4, 2012.
The FWC made several changes to black sea bass management in Atlantic state waters at its Dec. 5, 2012, Commission meeting in Apalachicola. Changes include increasing the minimum recreational size limit from 12 inches total length to 13 inches total length and lowering the bag limit from 15 fish per person to 5 fish per person. These changes became effective Feb. 18, 2013.
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The latest in the new set of Social Enterprise courses, Board and Executive Management of Nonprofits, was introduced in the fall term. The course represents a material change in the purpose of the School's nonprofit curriculum.
"In the past, we focused on the relatively small share of students who sought careers in nonprofit management," explains Professor Ray Horton. "The new approach recognizes that today's students, who are tomorrow's alumni, will also contribute to the nonprofit sector by serving on nonprofit boards and by donating money to the nonprofit sector."
"We need to prepare our students for all three roles," Horton says, "because a large share of our alumni during the course of their careers will contribute to the nonprofit sector as board members, donors and top executives."
The new course was offered as a six-week course in the second half of the fall term and drew strong evaluations from the 26 students who took it. Half of them plan nonprofit management careers, mostly in New York City, but others are planning to work in the private sector.
"I don't plan on working directly in the nonprofit sector after graduation," says Gwen Shufro '06, "but I plan to be actively involved in the sector, and I wanted to learn how I could contribute to nonprofits that share my concerns."
The course drew on a number of nonprofit leaders and alumni, including Paul Guenther '64, (pictured, photo credit: Chris Lee, New York Philharmonic), chairman of the New York Philharmonic; Frances Hesselbeim, chairman of the board of the Leader to Leader Institute (formerly known as the Peter Drucker Foundation for Nonprofit Management); and Mary McCormick '78, president of the Fund for the City of New York.
"I was pretty pleased with the first iteration of the course," Horton says, "but we would like to continue improving the course, particularly by developing cases that explore the complicated relationships among chief executives, board members and donors. I want to offer it as a six-week course one more time before elevating it to a full-term course."
The course is the third developed under the auspices of the Social Enterprise Program in the last three years. The first two were Business and Society and Finance and Sustainability, which were developed and are taught by Geoff Heal, the Paul Garrett Professor of Public Policy and Business Responsibility, and by Professor Bruce Usher, respectively.


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Register for Citi Field opener Tuesday
Mets fans can sign up through Feb. 24 for their chance at tickets
NEW YORK -- The Mets launch their online registration for purchasing tickets for Opening Day at Citi Field on Tuesday at 10 a.m. ET on Mets.com and LosMets.com. The registration for the online random drawing runs through Tuesday, Feb. 24. Opening Day, the first at Citi Field, is Monday, April 13, against the Padres at 7:10 p.m.
Fans registering automatically become eligible for the random drawing. No fee or purchase is necessary to register. A limit of one entry per person is in effect. No guarantee exists that those who register will gain an opportunity to purchase tickets. All purchases are limited to four tickets. The opportunity to purchase tickets is non-transferable.
A limited number of fans will be selected in the online random drawing. They will be notified via e-mail by Feb. 27. Ticket prices start at $27 each. All purchases must be made using a major credit card. Per ticket and per order fees apply. Season tickets are on sale now at Mets.com and LosMets.com. Information regarding the sale of single-game tickets for the inaugural 2009 Mets home season at Citi Field will be announced shortly.
This story was not subject to the approval of Major League Baseball or its clubs.


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The King Charles Spaniel is a breed of small dog in spaniel category known for its reserved, gentle, affectionate and well-mannered temperament. However, just like other dogs, training is necessary to teach this breed what is acceptable and what is not acceptable behavior. There are many objectives of training a dog. From the most basic […]
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Training A King Charles Spaniel
Filed Under: King Charles Spaniel Training Tagged With: Acceptable Behavior, Cavalier King Charles Spaniel Training, Cheerful Voice, Dogs Training, Encouragement, Interaction, King Charles Spaniel, King Charles Spaniel Training, Obedience Commands, Objective, Pup, Puppy, Social Relationships, Spaniel, Temperament, Train A Dog, Train Dog, Training A Dog, Training A King Charles Spaniel, Training Dog


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Olympia Entertainment revealed today plans for the Coke Zero Fan Zone, a five-day, 122,000-square-foot hockey fan event, that will take place outside of Comerica Park December 27-31, 2013.
The hockey and winter-themed event for all ages will take place in conjunction with the SiriusXM Hockeytown Winter Festival inside Comerica Park leading up to the highly anticipated 2014 Bridgestone NHL Winter Classic at Michigan Stadium New Year's Day.
"The Coke Zero Fan Zone makes one of the biggest celebrations of hockey ever, even bigger," said Tom Wilson, President & CEO of Olympia Entertainment.
Click here to view an event map
Click here to purchase tickets
The Coke Zero Fan Zone will be free to fans holding tickets to that day's hockey games at the Hockeytown Winter Festival. Admission for non-ticketholders is $5 each day with tickets available for purchase at the entrance. The event will span three heated tents with hockey-themed exhibits, interactive games and activities, autograph and photo opportunities and local music and food offerings:Hockey-themed Exhibits, Games & Activities:• Premier artifact exhibit hosted by the Hockey Hall of Fame• Full-size street hockey rink for ages five and older• Open skate on a full-size synthetic ice rink (hockey skates only please)• Hardest shot radar cage game• Top shot electronic hockey net game• Mini-sticks game• Bubble hockey game• Video game challengesAutograph & Photo Opportunities• Stanley Cup display with photo opportunities• Q&A sessions with Red Wings and Maple Leafs alumni• Alumni autograph booths• Locker room displays and photo opportunities in the stall of a favorite Wings or Maple Leafs playerFood & Entertainment• SnowZilla simulated toboggan slide• Bounce house• Local musical acts• Popular food truck vendors• Detroit restaurants• Hot cocoa and s'mores stations<• Fire pit warming stationsThe Coke Zero Fan Zone hours complement the Hockeytown Winter Festival inside Comerica Park:• Friday, December 27 from 1 p.m. to 10 p.m.(Great Lakes Invitational games MSU vs. MTU – 3:30 and WMU vs. U-M – 7 p.m.)• Saturday, December 28 from 1 p.m. to 10 p.m.(GLI Consolation Game – 3:30 and GLI Championship Game – 7 p.m.)• Sunday, December 29 from 11 a.m. to 8 p.m.(OHL games London vs. Saginaw – 1:30 and Windsor vs. Plymouth – 5 p.m.)• Monday, December 30 from 1 p.m. to 8 p.m.(AHL game Toronto Marlies vs. Grand Rapids Griffins – 5 p.m.)• Tuesday, December 31 from 11 a.m. to 4 p.m.(Red Wings vs. Maple Leafs Alumni Showdown games – 1 and 3:30 p.m.)
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Ah, Thailand, the Fairy Kingdom! It's not perfect, but it's the closest place to Paradise I know. Amid corruption, most of it harmless, and subsistence living, Thais are the happiest people I have ever encountered. Why so? They have a king who has devoted his life to the national welfare, strong family bonds, a warm climate, wonderful food, a low cost of living, including excellent and low cost health care, pleasant countryside, and a Buddhist way of life.
Thai culture is unusually accepting of gays. People do not think twice about them here, and so the gay movement is weak.
The photos in this volume show Chiang Mai, often listed as one of the five best cities in the world to retire to, the surrounding area, and the Thai North. Volume 2 will show Bangkok, the central, eastern, and southern parts of the country.


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New London, Conn - March 28, 2009 - In its outdoor season-opener, the Springfield College men's track and field team finished third on Saturday at the Coast Guard Invitational. Coast Guard won the meet with 171.50 points, followed by Westfield State's score of 131. The Pride rounded out the competition with a mark of 93.50.
In his first competition since winning the 55 meter dash at the NCAA Indoor Championships, Steve Headley set a school record and qualified for the NCAA Outdoor Championships with a time 10.54 in the 100 meters. Headley also anchored Springfield's 4x100 relay team of Matt Amendola, Tom Brognano, and Nickel Hay that placed first after crossing in 42.21.
Chris Quetant won the 400 in 50.02 and Brian Fuller won the 5,000 in 15:13.20 as both qualified for New Englands. In the 3,000 meter steeplechase, Kyle Moriarty took first with a 10:15.76.


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A new report out this week says sexual assault in the military has risen by over 30 percent in the last few years. Top aides to President Obama and members of Congress have met to discuss how to solve the problem. Indiana's Jackie Walorski was at those meetings.
She along with a Congresswoman from California have introduced a bill to protect victims of sexual assault. Specifically the bill would protect them if they report the incident. She said people are afraid of retaliation within the military system if they come forward about sexual abuse. Walorski says that needs to change because the numbers are too high. "I was appalled. I was absolutely appalled. It is, it really is something you have to have a zero tolerance for," said Walorski.
Walorski said the goal of her bill is to create a safe zone for people to report sexual assault. She said only after it's accurately reported can it be dealt with. After her meeting at the White House she's optimistic that will happen. "We're gonna see a major bipartisan group of women that once and for all and working with the president once and for all shutting this issue down and being able to eradicate."
Walorski said there is a lot of bipartisan support for her bill. It's been assigned to the armed services committee and will start on the Senate side soon.
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Italian Pork Chops Recipe
Skillet-browned chops are simmered with tomatoes, mushrooms and green pepper in this tasty treatment for pork. It's easy to prepare, especially if you buy the mushrooms already sliced. Adeline Piscitelli of Sayreville, New York
- 6 bone-in pork loin chops (6 ounces each and 3/4 inch thick)
- 2 tablespoons olive oil
- 1 large onion, chopped
- 1/2 pound fresh mushrooms, sliced
- 1 garlic clove, minced
- 1 can (14-1/2 ounces) Italian diced tomatoes, drained
- 1 teaspoon salt
- 1/2 teaspoon dried oregano
- 1/2 teaspoon dried basil
- 1/8 teaspoon pepper
- 1 large green pepper, julienned
- In a large nonstick skillet, brown pork chops in batches on both sides in oil; remove from skillet. Add the onion, mushrooms and garlic; saute for 5 minutes or until tender. Stir in the tomatoes, salt, oregano, basil and pepper.
- Return pork chops to skillet; arrange green pepper between the chops. Reduce heat; cover and simmer for 30 minutes or until meat is tender. Yield: 6 servings.
Originally published as Italian Pork Chops in Light & Tasty June/July 2002, p27
Light-Bodied Red Wine
Enjoy this recipe with a light-bodied red wine such as Pinot Noir.
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