text:
Funding opportunities
Endoderm-specific integration for human embryonic stem cells: towards tissue regenerative solutions for lung and pancreas
Funding Type:
Comprehensive Grant
Grant Number:
Funds requested:
$2 630 624
Funding Recommendations:
Not recommended
Grant approved:
Public Abstract:
Human embryonic stem cells (hESC) show great promise for tissue regeneration because of their propensity to make many of the cell types in the body. However, exactly how hESC can be directed to make specific parts of the body remains unclear. This is a major roadblock to harnessing the striking potential of hESC as a regenerative engineering solution for organ failure. Regeneration of complex tissues derived from the inner layer of the body called the endoderm such as the lung and pancreas is particularly challenging. We already have in hand several novel hESC lines that have a strong propensity to enter endodermal tissues in small scale culture systems. We also have already enjoyed preliminary success with other kinds of stem cells in getting them to enter and make lung in special kinds of mice. Now we plan to see if we can make lung and pancreas with our new hESC lines. Aim 1 We will try to force hESC to enter endoderm cell lineages by driving them with organ specific signals. Aim 2. We will see how hESC do when they are introduced into developing lung or pancreas because we think there are special signals that come from naturally growing tissue. Aim 3. We will see whether hESC can actually replace damaged lung or pancreatic tissue to simulate the repair of diseased tissue. This project brings together an experienced team of investigators with complementary sets of expertise in hESC, tissue development, tissue repair and tissue regeneration. We expect to discover a toolbox of critical factors that will drive hESC to integrate into and function as part of endoderm derived tissues and hence are likely to directly bring forward hESC based regeneration solutions for failure of the lung and pancreas. This work cannot be funded by the Federal Government because we will utilize novel hESC lines.
Statement of Benefit to California:
Diabetes and pulmonary failure are two serious and increasingly common problems among the children and adults of California. These serious public health problems lead to much loss of schooling and productivity every year. This proposal seeks to discover a toolbox of critical factors that will enable hESC to enter, integrate in and function as part of tissue regenerative solutions for lung and pancreatic failure. If we are successful, these critical factors may become medicines that will be critical to harnessing the potential of hESC as tissue regeneration solutions. The know-how for these critical processes will reside in California, giving the State a clear competitive advantage.
Review Summary:
SYNOPSIS: The specific aims of this proposal are 1) to create endoderm lineage-specific stem/progenitor cells from human embryonic stem cells (hESCs); 2) to develop novel assay systems to determine how to optimize the functional endoderm-specific engraftment of hESCs into endoderm-derived organs including lung and pancreas; 3) and to optimize the contribution of precursor cells to lung and pancreas regeneration in vivo. Methodologies to be used include: lentiviral infection or electroporation to establish expression of transcription factors, pharmacologic enhancers of differentiation; immunohistology; flow cytometry; Affymetrix and microarrays; murine genetic mutants, hESC microinjection into embryonic lung and pancreatic tissue; functional studies of Wnt, BMP, Shh, and VEGF; and in vivo treatment with hESCs of animals whose lungs and pancreatic islets have been injured by various modalities. SIGNIFICANCE AND INNOVATION: The goal is to investigate the possibility that hESCs can be driven to express key endodermal phenotypes that then can integrate into adult tissue and repair damage, all without forming teratomas. The specific tissues focused on are the lung epithelia and the pancreatic islets. If the hypothesis were supported, it would be very exciting with important implications for the field. Reviewers agree that creating new approaches to using hESCs to enhance endoderm lineage-specific stem/progenitor cells, developing new assay systems to determine approaches to optimize functional endoderm-specific engraftment of hESCs into lung and pancreas, and optimizing in vivo rescue of damaged lung and islet tissue in vivo would be innovative and important contributions. QUALITY OF RESEARCH PLAN: The proposal is considered an unrealistic, ambitious plan to drive hESCs to endoderm by lineage-specific ectopic transcription factor expression (Nkx2.1 for lung, Pdx-1 for pancreas) and to develop means of having them incorporate in vivo to damaged lung or pancreas. As steps to do this, the hESC will be genetically manipulated to express stably lung or pancreas lineage genes, endoderm will be differentiated, a novel assay for high throughput determinations of optimizing the niche in explanted mouse tissues developed, and non-invasive imaging of in vivo of injected hESCs partially along endoderm differentiation developed. However, the under-developed status of the preliminary data in the proposal and the sketchily described experimental plans themselves raise questions about feasibility (see below). According to reviewers, the proposal is not formulated as a proper research proposal and the quality of the research plan is seriously compromised by the lack of sufficient methodological detail, coherence, and preliminary data. Lack of this information makes the plan seem overly simplistic. The initial conception of the grant, i.e. that lung and pancreas arise relatively simply from foregut under the influence of one or a small number of known morphogens, is considered simply not correct. The aims are sweeping and unobtainable, that through a candidate gene approach (and a small number at that) lineage-specific lines will be obtained for lung and pancreas. Further, the applicant plans to apply these results to multiple tissue regeneration models. Throughout the proposal, there is essentially no strategic rationale or design. One reviewer noted that the discussion of statistics is particularly weak. While the concept of combining lung and pancreas as two endodermal tissues in the same project has some rationale, it dilutes the focus. Preliminary data show that 9% of the cells within embryoid bodies of mESC spontaneously express surfactant C; this is taken as an indication of ability to develop endoderm from ES cells. Lineage-specific lentiviral vectors based on controllable expression of the transcription factor nkx2.1 (and pdx-1) and GFP reporter are proposed to be all that is necessary to get ESC to specific endoderm; however, no details of this vector nor when would it be expressed nor how specificity of the resultant cell type would be obtained, and other details are provided. For example, pdx-1 is expressed in foregut endoderm that becomes antrum of stomach, duodenum and exocrine and endocrine pancreas; how would hESC be driven to islets? Many investigators have been trying to get endoderm populations under manipulated conditions and the protocols are improving, but no details about how this group plans to approach this are given. STRENGTHS: The expertise of the PI is cited as a strength. The PI is an expert on lung development and has a team with expertise in ESC, viral vectors, and bioinformatics. (The pancreatic development aspect is less well represented.) The lung explant model and the in vivo injury models are excellent for this project (however, those of the pancreas are less well developed. Usually for pancreas explants by E12, the stomach and duodenum are dissected away, leaving just the two pancreatic buds for culture.) There are 12 novel hESC lines generated at UCLA to be used (but no rationale is provided for using so many or nor how they will be tested is described.) The environment and facilites are excellent and all that is needed for this work. WEAKNESSES: Reviewers agree that overall the proposal is too broad and lacks details, appreciation of likely difficulties and a proper scientific design. The proposal presents unconvincing preliminary data. The lack of preliminary data using mESCs and hESCs that are available to the PI makes this proposal premature. Specific points raised by reviewers include the following. For Aim 1, the successful use of adenoviral vectors (which can introduce new cDNAs into cells transiently) to provide sufficient new protein to cells is marginal at best. Fig. 7 of the Preliminary data suggests this is possible in islets, and that introduction of PDX-1 has restored glucose control to STZ-treated mice. However, no images of STZ-treated islets are shown; it is not related how many animals are represented in Fig 7E, nor how many survived; it is not commented on whether any animals became hypoglycemic; no studies of glucose-stimulated insulin secretion were performed to demonstrate physiologic beta cell function; and no work was done with mESC or hESC. The latter omission is difficult to understand since the PI states he has 12 lines of hESCs to use. Why hasn't this already been attempted as a preliminary experiment? Another example in this Specific Aim is a description of experiments for lung tissue and the use of differentiation enhancers (inhibitors of PI3K and/or Exendin-4) with no information about drug concentrations or culture conditions. It is also indicated that development of novel vectors will be carried out in collaboration with Don Kohn via his current CIRM program proposal, which at this point is not been reviewed or funded. For Aim 2, plans are presented to study the effects of Wnt, BMP, Shh, and VEGF signaling using mutants and inhibitors, but no experimental details are provided. For Aim 3, it is proposed to inject hESCs through tail veins. This route might reach injured lung tissue, but almost certainly will not reach injured pancreatic islets because of lung capillary clearance. A superior mesenteric artery or even aortic injection approach would be much more feasible. How was the number 1.5 million hESCs established? No functional studies of pancreatic islets are proposed to insure that the hESC treatment will improve glucose-stimulated insulin secretion, which could be done in vivo and in vitro. No preliminary data using ESCs, mouse or human is provided, and easily could have been. No consideration of immune rejection by mouse recipients of human ESCs is even considered. One reviewer points out that preliminary data on mouse amniotic fluid stem cells are given for showing in vitro incorporation of cells into lung and pancreas. However, for the lung, there is no evidence that the diI fluorescence is within differentiated cells within the lung (Fig 5). Similarly the data on AFSC+AD-PDX-1-HA are not provided in enough detail (controls used, cycles) to accept these startling results. The low dose strep mouse model does not usually reach peak hyperglycemia until 10-15 days since there is an immune component in the destruction; many have made the interpretation that there is a recovery in this model as differentiation of new beta cells when actually it is an interruption of the further immune destruction. 3. Why are both luciferase and Ferridex labeling proposed for non-invasive imaging without trying to do any correlation between the two? None of the necessary controls are mentioned. How many cells can be detected using luciferase? How reproducibly? How well is the pancreas localized in either modality? Can there be distinction between pancreas (or lung) and the surrounding tissues? 4. Teratoma risk is high for injecting hESCs in vivo. There is some mention of this risk but monitoring of this over both time and tissues is unclear. 5. Intraperitoneal placement of islets does not work well; many more islets are needed. Additionally one might expect more risk of teratomas in the less specific niche. A reviewer suggests the following for improving the proposal: limit the studies to lung or pancreas; be more thorough in writing the experimental plan; collect preliminary data using ESCs that will allow an informed assessment as to the feasibility of the proposal. DISCUSSION: There was no further discussion beyond the reviewers' comments.


text:
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subset: commoncrawl


text:
Thread: Sports Writing
Sports Writing
I have a question to how hard is it to get a sports writing job?I am a 15yr old high school student that lives in illinois and i want to be a sports writer.How much do they get payed and how hard is it to be one.Thanks
Re: Sports Writing
Is anybody gonna help a brother out? This is my career choice man..Help me out!!!
Re: Sports Writing
"DaVizzles" wrote:
Is anybody gonna help a brother out? This is my career choice man..Help me out!!!
Probably why nobody replied.
I am thinking you clicked on a topic in the "Latest Talk" and just started a New Topic.
Have to go the the Forum Index and select the proper forum.
Also, gotta give people more than 9 minutes.
Re: Sports Writing
"DaVizzles" wrote:
Is anybody gonna help a brother out? This is my career choice man..Help me out!!!
I don't know anything about it.
Recommend you contact a counselor at school.
He/She can probably help you out with things like pre-reqs, colleges that offer courses etc etc.
Also I have found that google is a great source for info.
Maybe you could google a few key words or phrases to see what you can get that way.
Good luck in your quest.
;DMany many thanks to my talented friend Jos for the new Sig.
Re: Sports Writing
This is my same career path at this point. I'll tell you right now that the most highly touted school for journalism, broadcast journalism, and sports journalism (that's what you'll want to go into in order to become a sportswriter or analyst) is the newhouse school of communications at Syracuse University. In order to get into Newhouse school under the new standards, you likely need 4 AP classes in high school, all A's and B's, top 5% of your high school class, and a very high SAT score. Now there are a lot of other Journalism and Broadcast journalism schools out there so I would consider talking to a college counseler at your high school and ask them about your career path.
Now I don't know the typical wages for a sports journalist but I imagine it varies as you go from lower to higher scale (local papers, local radio stations to things like sports illustrated and other high profile magazines and ESPN etc). I wouldn't expect something big starting out
How hard is it to be one? I don't know. It really depends on a lot of circumstances. Most people say it's the easiest job in the world but you can say that about almost anything and then it's a lot harder than it looks when it comes down to it. Do you get good English or Literature grades? Do you truly have a passion in sports or is this just a spur of the moment thing. If you truly are interested I would look for old episodes of the show dream job on ESPN. Cool stuff.
I hope that helped.
Re: Sports Writing
Yea man thanks alot. You said this is your career path? How old are you? Are you in college if so what college. I will probably go to Northern Illinois University or Beloit Community college possible Chicago St. Do you think these are worthy colleges to get a good job with.....Thanks alot
Re: Sports Writing
The most important thing is to talk to a college counseler to help you decide what you need to do in high school to help you later on in college (School newspaper? Morning announcements or school television? School Radio?) I'm no expert on this and the people at your school will be able to tell you where you could go with your grades and PSAT scores etc. There are plenty of large land grant state schools across the united states that have great journalism schools. I would ask a teacher or something if there's a college counseler you can talk to right away. They're the experts.
Re: Sports Writing
If Kevin Hench can keep a job as a sportswriter, then you both have a very good chance of succeeding!BANNED OR DEAD...I'LL TAKE EITHER ONE
05-01-2007, 01:00 PM #9Training Camp
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Re: Sports Writing
Checking with an advisor at school as to what colleges offer the best in the way jounalism is good advice. If you find that writing your essays is the most rewarding thing that you do at school, then you are probably headed the right way with your choice of writing as a career.
While you are pondering these choices, there are a few freelance web sites out there whereby you may get a chance to test your abilities as they often are looking for sports writers.
Have a look at elance, It's a site which hooks up writers and customers who outsource their writing needs. I did some web writing there on sports a few times. It's not all that financially rewarding, but you learn about deadlines, quality writing needs, and the pressures of finding good topics on a regular basis. It's a bid/offer set up, and it takes some time to get a bid accepted. There is, however, a fee for joining and continuing as a bidder, which I do not agree with, but that's where the site makes it's money.
Good luck finding a school that will give you the courses that you are looking for, I wish you well.
Re: Sports Writing
Another school with a great journalism program is Northwestern. A LOT of guys in mainstream media have come from the Medill school of journalism at Northwestern University (Michael Wilbon and Mike Greenberg to name two).
Here's some info. on the profession:
Just like any career, it's going to be hard to end up like Wilbon or Greenberg. I'm sure there are 1000s of journalism majors around the country right now with the intent of going into sports writing.
Most will start out with small jobs, basically being the bitch boy for a local paper. If you're lucky you can get into a big city (Chicago, New York, LA) and work your way up from the bottom, but even the entry level journalism jobs at those places are difficult to come by.
If you look at most ESPN type guys (if that's what you aspire to be) they have made a splash somewhere else. No one comes right out and gets a job at ESPN, Sports Illustrated or a major newspaper. Mike Greenberg (who graduated from Northwestern's school of journalism) started in Chicago covering the Bulls and White Sox, etc. for a radio station and then left there for another radio station and ended up in TV for about 5 years before coming to ESPN.
Colin Cowherd (another ESPN Radio host) although not a journalism guy, started out small doing play by play for a minor league baseball team on the west coast. Then he held down jobs in Tampa, Portland and was a five time sportscaster of the year in Las Vegas. Then ESPN brought him in...he made a splash somewhere else and came in.
Wilbon started with internships at the Washington Post when he was 21 and worked his way up the food chain.
Like I said, it's hard and very few guys make it that far. You have to be VERY GOOD to do anything on a national level.
I hope some of that helps.
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Suunto Ambit
4-star: 0
3-star: 0
2-star: 0
1-star: 0
78 g / 2.75 oz
The Suunto Ambit is the most advanced ABC/GPS Navigation…
Source: bought it new
Price Paid: $500
The Suunto Ambit is the most advanced ABC/GPS Navigation Trainer watch. It's a Game Changer.
- Solid build construction
- Advanced GPS with total adjustability
- Screen display is the sharpest made
- Fast GPS lock up times
- 3D compass that can be used while moving
- Adjustable backlight that is so bight you can read by it.
- All new altimeter and barometer sensors
- Firmware updates adds all new features
Suunto Ambit reviewed by a hunter/outdoorsman's perspective.
I am going to try to do a review of the new Suunto Ambit Black GPS navigation training watch. This is going to be difficult because the Ambit is an evolving product with many firmware updates planned by Suunto for additional features. As a longtime multiple ABC watch owner, I can safely say that the Ambit is in another league. It's a "game changer" for outdoor watches.
It is so much more advanced over my beloved Suunto Core, that it would be like comparing an 8-year-old basic Cell phone to the latest iPhone smart phone. The Ambit, even as just an ABC watch, uses all new sensors and does the ABC thing better and more accurately than the Suunto Core. Up till now the Suunto Core was the gold standard of ABC watches.
The Ambit is a big watch. It is not heavy and is very well balanced. The strap is very good and has a waffle pattern that allows your skin to breath and allow water to escape when swimming. It is long enough to strap over a light jacket or just over your skin.
It is worth noting that the strap is now connected to the head of the watch with allen head screws and not the typical flat head screws of the past. The size of the Ambit is thicker than the Core but if you can wear the Core as a every day watch, you can wear the Ambit as an everyday watch. It's that simple. I found it slips under my winter jacket cuffs without any problems.
The Ambit is designed and manufactured in Finland and is Suunto's halo watch. Its build quality is a tank and a notch above anything Suunto has produced previously. The button push is solid and smooth. The watch oozes quality and feels very reassuring if you were to use it in the real rough stuff. The display is another feature that blows any other digital display away. It has a very high dense pixel count and is crisp and sharp. The closest analogy I could use would be the Core's display is standard def tv, the Ambit is like a 1080P LCD hi def. It's that good and is a major feature to this watch.
Your main interface with this watch is its display and having the sharpest display available gives the user a giant advantage over anything before. The unprecedented feature of this display is its ability to switch display from positive to negative display with a push of a button. No longer do you have to buy a separate watch for two great looks. The negative display is very cool looking and is way more legible than any negative display by any manufacturer. The positive display is just as impressive. I can read the negative display from 8' across the room and can read the positive display 10' away across the room.
The adjustable back-light may be the brightest I have ever seen and was only at 50%. It's so bright you can read by the light (no joke). I have not seen how bright 100% is. I lowered the back-light to only 30% and it's still brighter than any back-light I have ever used. The Core's back light would be a 3-5% in comparison. Very impressive.
The Ambit has a screen-saver to save battery life. If the Ambit doesn't sense any movement in 30 minutes, The screen is turned off but all measurements are still active. The slightest movement brings the Ambit's screen to life.
The alarm has a very high quality multi tone chime. When the alarm sounds, the light comes on and stays on 10 seconds after you push a button to either turn the alarm off or activate the snooze. Of course, you can adjust features like the light during the alarm,etc...
It's hard to narrow down the Ambit on who and what it was designed for. It is so versatile and can be custom tailored to about any and all activities. It's a training watch that can be easily linked with a heart rate or bike pod strap. It has very detailed training logs that go way beyond my use.
The Ambit is a navigation watch for trail running, mountain climbing, hunting, and any sport you might find yourself doing in the mountains. It's great for motor-sports like motorcycle riding, ATV riding, boating, etc... You get the picture? The Ambit can be custom designed by the owner through Suunto's free downloadable software called "Movescout". You can totally adjust all features and settings via Movescout on your computer if you want.
The watch is powered by a internal lithium-ion rechargeable battery that is charged through any usb power source. The Ambit comes with an alligator clip adapter that clips to the watch and makes contact with contact points on the bottom of the watch. Simply plug into any USB plug on your computer, AC adapter, car adapter, or even a solar USB charger. However you would charge your iPod, you can charge the Ambit.
Battery life depends on how hard you run the gps. As a standard ABC watch the battery life is 30 days. When using the gps the battery time is 15 hours with 1 sec GPS fix and 50 hours with 60 sec GPS fix. The watch always remains sealed and Water Resistant to 100M. The Ambit has more in common with an iPod than a watch. Even the way the Movescout mirror syncs between the computer and watch parallels Apple's iTunes and a iPod. That should open up a lot of endless possibilities.
How does it perform?? Let's dive into only the ABC functions. The Ambit is using a totally different sensor than the Core. It finds its altitude quicker and doesn't bounce up and down as much. I set the altimeter to a reference of 997ft. I then would run up and down three flights of stairs in my house. The Ambit changed as fast as I could move and when I would stop half way up, the Ambit's numbers would stop. It was like it was locked into a gps signal but it wasn't.
The set up is similar to the Core but with many more features to set. The Altimeter now has a 12 hour graph. The Barometer graph is 27 hours long. Like the Core, the Ambit has an Altimeter profile for hiking and telling the altitude. A Barometer profile that tells the weather trend and a automatic profile that lets the watch decide the correct profile for the activity.
The compass is another major upgrade. The compass no longer has to be held flat and still for a correct reading. It has 3D compass which allows for readings on the move. The temperature reading still has to be removed from the wrist for accurate readings without your body temperature effecting it. A side benefit helps keep the Barometer more accurate knowing a approximate temperature internally.
Now the big news,..The GPS. The Ambit uses the latest SiRF star IV technology. Cold lock up times were very fast and compatible to my cars Garmin Nuvi 3490 at 14-20 seconds. After that lock-up times were almost instantaneous. Lock-up times inside my 3 story brick house on the first floor is 3 seconds. That's about as good as it gets and is outstanding on a wrist gps.
In car performance on the wrist was just as good. The internal memory holds 100 waypoints that can be set on the watch in real time or in the Movescout program. It is very easy and intuitive. Perfect for marking your parked car before entering the woods and then mark a few landmarks along you days journey. The watch has a long list of icons and preset labels that can be personalized more detailed if you like.
The Ambit has custom profiles that Suunto calls "training logs". A training log is a custom set of priorities you design your Ambit to do. The possibility are endless.
As you can see by my pic I set my Ambit up for ATV riding and any motorsport that looks and locks onto the gps signal and records a waypoint every 1 second. A general Hunting stopwatch timer that mirrors features similar on the Core like altitude, etc...but doesn't look for a gps signal. Trekking that looks for a gps signal and marks a waypoint every 60 seconds. These are very very basic exercise modes I have designed on Movescout. I cant stress how many options and tasks you can custom tailor and store as a "exercise log" in your Ambit.
I am going to wrap this review up because I could go on and on with the features of the Suunto Ambit. Remember many new features will be released as firmware updates for the Ambit like storm alarms, count down timer, and who knows what else??? At the time of writing this review, the Ambit Black was getting very hard to find,... The MSRP is $500 for the Ambit a $550.00 for the Ambit with the additional heart monitor. You can always buy the Suunto heart monitor at a later date. It is a standard Suunto accessory and your Ambit will link up with it in under a few seconds. I purchased mine at "CleverTraining.com".
Suunto is currently asking what features its users want at email@example.com. This shows the company has great plans for the Ambits future. It's an exciting and brand new world for Suunto and the Ambit. It could be Suunto's most significant watch and is certainly their most complex and versatile ABC/GPS Navigation/Training watch.
I recently purchased this watch for a hunting/trek…
Source: bought it new
Price Paid: $348 and worth every penny spent!
I recently purchased this watch for a hunting/trek in August. I was not disappointed. This watch is perfect for any outdoor person wether an outdoor adventurer/military/law enforcement. The watch is easy to use and compare to several other outdoor watches this watch super-cedes all. It is large, the buttons are easy to use and it took me about 2 days to master it. It has a gps, barometer/altimeter, several countdown timers, can change from a black face to grey face. Overall I'm using this watch over my other outdoor watches. It has not failed me yet.
- Big, easy to use
- Mil spec I think
- Outdoor adventurist dream watch
- Tons of efficient buttons for gps, altimeter/barometer
- Tactical black with nice rugged wrist band
- Heart rate monitor
- Suunto warranty, this watch rocks!
- Rechargeable- lasted me 9 days without a recharge
- Middle button can interfere with hand if you got a fat wrist
I recently returned from a 7-day hunting/ trek in the Trinity Alps. I purchased this watch because I heard about it on a website. When I got it I was amazed by everything detail that Suunto provides. The watch comes in a awesome box that is geared to anyone who has any type of outdoor background. It is stylish, set up is easy and once charged and place on your wrist you're gonna love it. I mastered the watch very rapidly within 2 days without looking at the manual.
I am sort of a gear junkie since I was in the military and love proper gear that works! This watch does everything from temperature readings, compass, night readings with two types of screens. You can have the grey screen or tactical black screen. I love all the features. You can plot gps points and accurately get back to you points of interest.
This watch is water resistant and when you have to jump in a lake to clean up you don't have to worry about it not working. This watch is dependable and trust worthy. If you have a fat wrist like I do you will find out that the watch will slightly rub and press the middle button. It can be overcome by pressing the locked button.
Overall I buy the beat gear. I don't settle for cheap but I do shop around to get the best quality products because when you are roughing it in the mountains and have to rely on your gear you should only settle for the best.
Where to Buy
Manufacturer's Description
Retailers' Descriptions
Here's what other sites are saying:
Perfect for outdoor athletes, the Suunto Ambit2 S GPS multifunction watch provides the key training data you need (speed, distance, bike power, swim stroke) to take your performance to the next level.
Whether it's a week-long bike tour in the Pyrenees, a backcountry ski tour in the Wasatch, or a summer of training for a marathon, let the Suunto Ambit2 GPS Watch supply you with every bit of information you need. Full GPS functionality pinpoints your location and elevation, and it keeps you on course while the barometer graphs changes in pressure and alerts you to impending storms. You can also quickly switch between running, cycling, training, and swimming modes for instant access to pertinent information like lap times, calories, and total distance. Plus, the watch battery can be recharged via USB, and over 1000 free applications are available from Suunto for even greater customization.
- Backcountry.com
All the features needed for running, cycling, swimming, and hiking-navigation, pace, distance, weather conditions, altitude, and more-make the Suunto Ambit2 a necessity for outdoor athletes and explorers.
Suunto Ambit2 S HR - The stylish Ambit2 S White comes with a soft, elastic strap for greater comfort on women's wrists. The Suunto Ambit2 S is designed to fuel your passion for sports. Latest GPS in a light and sleek design with advanced features for running, biking, swimming and more. Thousands of Suunto Apps available to add new features to your watch. Perform at your absolute best - every time, everywhere. PRODUCT HIGHLIGHTS Advanced multisport functions Personalize with 1000+ free Sports Apps 12 h battery life with GPS Improved fit for smaller wrists
- Massey's Outfitters
Suunto Ambit
$239.93 - $550.00


text:
The Erie Otters won't give up on getting Andre Burakovsky in their lineup next season.
"I believe the best possible (way) for Andre Burakovsky to become a professional (hockey player) is to come and play with us," Dave Brown, Otters assistant manager of hockey operations, said today in response to reports that Burakovsky, the fifth overall pick in last week's CHL Import Draft and the Washington Capitals' first-round pick in the recent NHL Entry Draft, won't report to the Otters.
Brown said Otters officials weren't surprised when they learned of the initial report Monday, which was in a tweet from Ryan Kennedy of The Hockey News. Kennedy reportedly received confirmation from Kevin Epp, Burakovsky's agent with Titan Sports Management of Vancouver, British Columbia.
Brown said club officials have yet to speak with Epp and Burakovsky. Yet they received conflicting thoughts before the CHL draft regarding Burakovsky's hockey home next season. Contacts within the NHL told Brown that the Austrian-born Burakovsky would play in the CHL. Patrik Aronsson, his agent with AC Hockey AB in Molndal, Sweden, told Brown that Burakovsky wouldn't report.
Meanwhile, Brown has received positive feedback from Capitals officials, namely Director of Player Development Steve Richmond, about Burakovsky joining the Otters. "They think it's a great idea (that) he play in Erie and get to play on a line with Connor McDavid," Brown said.
Now Otters officials will wait to learn about the Capitals' plans for Burakovsky. The Otters also plan to speak with Epp, Brown said, to "prove … we are as good an organization as we think we are."
Note: I'm waiting to hear back from Sherry Bassin, Otters managing partner and general manager, who was unable to speak this morning because he was in a meeting. Epp hasn't returned a message left earlier today, while Aronsson has yet to respond to an e-mail. Check back for updates as well as a report in the Erie Times-News on Wednesday
- Victor Fernandes


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Democratic voters in Harrisburg have said no to a second term for Mayor Linda Thompson, and have picked Eric Papenfuse to be their mayoral nominee in the November election.
Thompson conceded defeat Tuesday night after finishing third behind Papenfuse and city controller Dan Miller in the Democratic primary.
"We worked hard -- really, really hard," Papenfuse said after his victory. "We ran out every ground ball, we went door-to-door in every precinct of this city, we had an aggressive media strategy, and I think we worked harder than any of the other campaigns, and it paid off."
With 100 percent of precincts reporting, Papenfuse, a small business owner, had received 39 percent of the total with 2,467 votes, according to the unofficial tally.
Miller had 32 percent of the vote with 2,066 ballots cast for him, and Thompson had 1,810 votes, or 28 percent. Lewis Butts Jr. received 64 votes, or 1 percent.
Thompson, who was Harrisburg's first African-American mayor and the capital city's first woman mayor, told abc27 News that she will leave the mayor's office with her head held high.
"My legacy goes well," she said. "I came in with four priorities - that was fiscal solvency, focusing on business growth, job creation and public safety - and I think we've done that and we've done it well. The worst fiscal crisis in the history of the City of Harrisburg, and few could walk that journey, and I think I walked it well."
Papenfuse will face Independent candidate Nevin Mindlin in the November election. Mindlin lost to Thompson as a Republican in 2009.
No Republican candidates ran in the primary, but Miller ran a write-in campaign on the GOP ballot and 424 write-in votes were awaiting an official count. A candidate with at least 100 write-in votes could have a spot in the general election.
For more vote results, visit http://www.abc27.com/category/200274/election-2013-vote-results
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SEABROOK, N.H. (AP) — A New Hampshire woman accused of forcing her two young children to drink bleach is being held on $200,000 bail.
Wendy Wright of Seabrook has been charged with two charges alleging she "knowingly attempted to cause serious bodily injury" to her children, ages 6 and 7.
Police say Wright induced her children to consume the chemical last month at their home. All three were taken to hospitals. Authorities say both children were released from the hospital and are doing well.
Wright's lawyer, Tony Naro, said prosecutors' $500,000 bail request was excessive. He argued for $1,000, saying it was all her family could afford and that she's undergoing mental health treatment and won't be able to continue if kept in jail. A judge set the bail at $200,000 later yesterday.


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Let's not forget the reason for the FDA's existence. The agency was formed to assure the purity of food and drug products (1906). They went on to regulate drug safety (1937) and then drug efficacy (1962). The efficacy regulations were in response to what was truly a safety issue—the use of thalidomide in pregnant women. The FDA is the institutionalized embodiment of the Hippocratic Oath to "first do no harm." They are cautious because that is their job. Safety does come first. You can always replace a drug that's not working, but you cannot replace a patient who has died. Suggesting biosimilars could be approved without clinical data is not a very cautious position to take and leads one to wonder about the possible motivation of the FDA in taking that position.
Of course companies are not impartial bystanders on this issue. However, the figure below, which appears on a leading biopharmaceutical company's website,* does nicely represents the situation at hand. The complexity and size differences between small organic molecules and biopharmaceuticals are enormous. Complete physico-chemical characterization is probably never truly achieved for a biopharmaceutical product. They are not small molecules.
By definition, within the realm of biotechnology, microorganisms are used to produce drugs, hence the term biopharmaceuticals. These microscopic "chemists" are not following any prewritten procedures or SOPs; they don't have lab notebooks. They are living organisms, greatly affected by their environment and the process conditions under which they "work." The biopharmaceuticals they produce have three or four levels of structure. These therapeutic proteins can fold; they can aggregate; they take the form of alpha helixes in some regions and beta sheets in others. In addition, they are equally if not more susceptible to all chemical degradation processes that can inactivate small molecules or make them toxic. Plus, they can be immunogenic.
Sometimes small changes in biopharmaceuticals are not readily detectable by analytical methods and sometimes they can affect the safety and efficacy of the final product. In many cases animal data regarding safety and efficacy is not very reliable since for many biological substances there are species-specific structural differences in the biopharmaceuticals they produce.
In essence, the complexity of biopharmaceuticals as drug molecules plus the inherent variability in how they are produced make them difficult to duplicate. This difficulty is sometimes encountered within the same company when transfer between different manufacturing sites is attempted. Imagine how much more challenging it will be to validate that successful duplication has occurred between the reference company and a new biopharmaceutical company. Imagine trying to conduct this validation without clinical testing. I don't believe it is very likely.
In their communications, the FDA highlights the fact that they can waive the requirement for clinical studies for biosimilars, but would they? Could they? Would you want them to? What argument would convince them not to test a biosimilar in humans and remain true to their mandate of safety first?
The whole issue reeks of political hokeyness, unbefitting serious healthcare issues. Biopharmaceutical sales comprise about 15% to 20% of overall pharmaceutical sales; therefore, savings in this area will not have a dramatic effect on the health care bottom line. Biopharmaceutical products are usually critical care or life-saving treatments administered in a hospital by injection or infusion. Manufacturing and testing of biopharmaceuticals is complex and will remain complex. Only large, well-funded companies will be able to afford to make them—a vastly different situation than banging out millions of acetaminophen tablets on an industrial press to generically replace Tylenol. Biosimilars are not generics, could never be and any suggestions to the contrary should be avoided.
A company on the path for approval of a biosimilar will always have to face the prospect of long and expensive clinical studies. The process will be beyond the capabilities of a mom and pop operation, and costs will go up.
I don't think the FDA wants to look like the bad guy here. They would like to avoid the appearance of stifling competition or of being unresponsive to health care reform. The FDA states they will judge each biosimilar on a case-by-case basis, which is good but is also a way of avoiding accountability.
So why the big fuss? The risks here will be borne by the investor and the patient, and I am not sure what the benefits will be. The litigation scenarios are almost limitless. The government should make some clear regulations about exclusivity, since patent issues with natural products are complex, and let it go at that.
Since in reality the hurdles to approving a new biopharmaceutical will not change much, the complexity and cost of producing new biopharmaceuticals will not change much, and their impact on the overall cost of healthcare will not be significant, the furor and anticipation surrounding issuance of the biosimilar guideline . . . is, unfortunately, much ado about nothing.
*Genentech's web page on biosimilars.
Related site: click here for a good executive summary of biosimilars.
To read Part 1 of this blog, click here.
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Routes Sorted
L to R R to L Alpha
Splash starts off the ledge on the right side of the block. Squeeze behind the block to a belay anchor. Splash heads up the west face of the block and on to the main wall proper. Two clips and a thinish 5.11c/d move initiate the route and dust the crux. Jog left above the block and immediately jog back right to head up on more moderate terrain. A bit run out higher up, but the climbing eases back to 5.9. Good continuous climbing on largely fine rock that has been well bolted give the line two stars. Splash is route number 10 in Rolofson's guide to Clear Creek. Since it begins on the mid-level ledge, use one of the approach pitches. Starting up on Grilled Trout (#3, out of the water), lands you at the base of Splash without scrambling the ledge and makes for a logical two pitch climb.
QD only. This 70ft route needs 9 - 10 draws and something for the two bolt anchor at the top.


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Police hunt Bradford's big-nosed robber (From Bradford Telegraph and Argus)
Get involved: send your pictures, video, news and views by texting TANEWS to 80360, or email
Police hunt Bradford's big-nosed robber
7:07pm Sunday 26th January 2014 in News
A man with a big nose tried to rob someone on a cul-de-sac in Wibsey, police say.
The attempted robbery, which involved other suspects, happened at a house on Somerville Park.
The offence came to light after police released details of crimes in the Wibsey ward between January 19 and Saturday.
The suspect is described as Asian, 5ft 5in, slim, 20 to 25, with black hair and black eyebrows. He was wearing a light-grey Adidas hooded top and black leather gloves.
Anyone with any information the offence can call Police on 101.


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Start something new!
Everyone should have a hobby, right? Maybe you're not sure where to start, or you've made it to expert level with a different hobby and need something new.
Here's a list of 10 great (and free!) online courses that can help you start a hobby with some expert assistance.Read More »
10 Hobbies to Take up with an Online Class
With so many options for hobbies to take up this summer, try these 10 ideas paired with a go-at-your-own-pace online class.
9 Hot College Scholarships to Check Out This Summer
Scholarship money for college is a must in these days of rising tuition costs, and finding college scholarships has never been easier than through ScholarshipAdvisor. Start out with these great college scholarships that have summer deadlines, then find and bookmark even more!
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College Career Services offices are not the same old résumé helper. They are preparing students with lifelong professional skills for today's job market.
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What are the best types of retirement jobs? In this exclusive interview, the CEO of Retirement Jobs shares expert career advice for midlife job seekers.


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Classic Saint Laurent skinny knit tie with two-toned, checkerboard pattern.Width: 1.2 Inches
100% Silk
Silver-toned metal chain loop
Style ID: 3166864Y0151077
Made In Italy
Some color/size variations are shipped from our local warehouse and can be available for Next Day and Saturday Delivery.
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Zach Randolph could miss up to two months due to a knee ligament tear suffered early in the Memphis Grizzlies' Sunday loss to the Chicago Bulls, reports Ron Tillery of the Memphis Commercial-Appeal. Randolph's injury initially looked ugly, but the news was positive after the initial examination, and the All-Star power forward was expected to miss only a couple of games.
But a closer look during Z-Bo's recovery has killed that hope, and Randolph will need some serious time on the shelf.
The Grizzlies are reportedly in the process of acquiring Philadelphia 76ers forward Marreese Speights in a trade sending guard Xavier Henry to the New Orleans Hornets. Speights may either plug into Randolph's starting spot or fill in behind Dante Cunningham, who started for Randolph on Tuesday against the Sacramento Kings. Sam Young played a smallball four behind Cunningham on Tuesday, and lit the small Kings up for 20 points.
Randolph gives the Grizzlies two seemingly devastating injuries in two years; the team missed Rudy Gay for the entire post-All-Star break last season due to a separated shoulder. Despite that loss, the Grizzlies made the playoffs and beat the No. 1 seed San Antonio Spurs in the first round. Memphis hopes to repeat the task this season, though the team's frontcourt depth is much more shallow than the wing depth had been last season.
For more on the Grizz, visit Straight Outta Vancouver.


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faculty profile
Brett Reichman
Associate Professor
My highly detailed, labor-intensive approach to realism addresses the complexities of identity politics. Through the post-modern staging of the figure in performative situations with objects, I question societal norms by painting images of exaggeration and artifice. This inquiry into the politics of gay culture critiques political correctness and cultural assimilation through images that convey an amplified visibility and difference. My approach to realism is never simply reproductive. I separate the concept of realism from naturalism within a discourse that views popular culture as anxious, obsessed with artificiality and unnatural beauty.
Selected Exhibitions:
- Simulations, Gallery Paule Anglim, San Francisco, CA, 2010 (solo)
- Silence, Exile and Cunning, Sonoma Valley Museum of Art, 2010
- Pacific Light: A Survey of California Watercolor 1908-2008, Nordic Watercolor Museum (Nordiska Akvarellmuseet), Skärhamn, Sweden, 2008
Selected Publications:
- Pacific Light: A Survey of California Watercolor 1908-2008 Nordiska Akvarellmuseet, Sweden, 2008
- Untitled Publication (Red Square), Feature Inc., New York, 2007
- Art – A Sex Book, John Waters and Bruce Hainley, Thames & Hudson, 2003
- BFA, Carnegie Mellon University
- MFA, University of California, Berkeley


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When Tiffany Hassler Johnson heard what she describes as a "dull bang" coming from the downstairs of her Vallejo, CA, home, the last thing she expected it to be was a gunshot.
But it was. And there was her son, Cody Hassler, 20, the oldest of four siblings, running to the stairs and crying, "Mom, I've been shot."
Johnson screamed to her oldest daughter to call 911, she said, and ran to Cody and held him until the paramedics arrived, thinking this must have been a drive-by shooting.
"Another friend of Cody's ran in," recalls Johnson, "and said, 'Cody, you alright? Relax bro, they are coming.' I turned and asked him, 'Where is Sammy?'"
Sammy Turner, 19, longtime friend of Cody's since 6th grade at Cunha Intermediate School in Half Moon Bay, CA, spent a lot of time with Johnson's family. Especially within the last two years, "Sammy had issues with his father or other problems, and Cody would bring him out to our house," said Johnson, who knows all too well the pain Turner has experienced over the years, abandoned by his mother at an early age and raised by a single dad.
Johnson, too, is "one of those broken and damaged kids," she said.
And now? "I'm the keeper of our lost and hurt kids and adult kids. I have this drive to wanna love and fix these people. I would just be there for my kids' friends, feed them, clean their clothes, remind them to shower, and to just say, I'm not perfect, but I do care."
She cares so much she tried everything she could on Tuesday to reach Turner, who fled from her Vallejo home and was hiding from law enforcement officials in his El Granada apartment before the San Mateo County SWAT arrested him Wednesday morning after shooting her son in the stomach for reasons still unclear.
"I began to call anyone I could think of to get access to the negotiators but it didn't seem like they were taking us seriously," she said, "and then I came upon Half Moon Bay Patch, desperate to get some information, and then I had an idea."
She sent messages to Sammy on Patch:
She also uploaded a video of Cody in the ICU at the North Bay Medical facility in Fairfield, saying he forgives Sammy for shooting him and cares about him and their friendship. Their hope was that this would reach Sammy and coerce him out of the apartment to end the standoff peacefully with a SWAT Team at his door.
"As Cody was in and out of consciousness, he would cry and ask about Sammy and beg me to do something. Cody was sure he could talk him out [of the apartment] without incident," she said.
Cody without hesitation taped his plea to Turner, said Johnson.
"It was so touching to watch my son have such devotion to this boy he calls his best friend that just shot him. I am changed forever, and I am so proud of my son that he has that kind of heart even after his own letdowns and disappointments. I couldn't do anything more than to love and honor my son by loving and forgiving the boy who almost took my son from me."
Still, Cody and Sammy weren't so tight in the beginning. When they first met in middle school, they fought, said Johnson.
"But quickly Cody saw in Sam something that others didn't see or maybe didn't understand," said Johnson. "He saw how Sammy was treated by the group of boys he considered his friends. Cody took an interest in Sammy and there started their brotherhood. Cody got him. He really understood Sammy and saw and felt all his pain. Cody just became very protective of him."
Johnson says her son also feels pain from an absent father, distant relationships with siblings and other close family.
"As a younger child, Cody also suffered from severe hearing loss, and some behavior issues, which resulted in him being bullied a bit," she said.
During his high school years, Cody was in and out of youth authorities. In 2010, he graduated out of the program and returned home to Half Moon Bay to find Sammy, about to graduate from Half Moon Bay High School, still hanging out with old friends, many who started coming over to Johnson's house on a daily basis.
She describes Sammy as a "brilliant, loving, compassionate kid" and "a victim of an absent mother and a father who did what he could."
"Sammy was just the kid that was a little off," Johnson said.
His mental state, however, became worse over recent months, and whether it was brought on from an emotional illness or substance abuse or both, Johnson doesn't know, she just noticed that "his behavior was becoming a little more erratic," she said.
A month or so ago Sammy went missing, she said, and she and Cody were very worried.
"We looked for him everywhere, checking hospitals and jails," she said.
Then, about three weeks ago, he showed up at her new house, now living in Vallejo since making the move from the Coast in December 2011.
"He was very upset and sad," said Johnson. "I put him in the shower, fed him, and told him to go lay down till Cody got home. Sammy confided in me that he really missed his mom and wanted to find and contact her so I sat down with the very little information he had on her and started to search."
Johnson says she couldn't find much more on her and when she told Sammy, she saw a "lonely, hurt, boy, that felt unloved, and unworthy," she said. "I got so sad and told him no matter the problems his parents had that they loved him and that his mother has unfortunately missed out on a great kid."
Sammy stuck around Johnson's house the next couple of weeks and the guys quickly got into "a groove of hanging out and going to local raves and events with friends," said Johnson.
"The two of them seemed to have a sixth sense about each other. They spent all day and all night hanging out and playing video games."
Then Monday, Nov. 26 came. Johnson returned home from running errands and found Cody tearful, saying that Sammy was upset and left after they were bickering back and forth.
"I reminded Cody that this was his friend, who was in emotional crisis and to be gentle and talk about what they were arguing over," she said.
Still, Cody says he's not entirely clear on what the trigger was but "they argued and I think Sammy just had a break of reality due to the trauma he has been dealing with concerning his father and the lack of any communication with his mother," he said.
And somewhere a gun came into play and Cody was shot in the stomach by his best friend.
"Out of confusion and desperation, I'm thinking Sammy in a stable mind would have taken a bullet for Cody not discharged one into him," said Johnson. "Sammy is broken and profoundly scarred by his past. I just hurt for him. As a mom, I just want to grab him in my arms and hold him and make him feel safe and wanted. I just want to replace some of his pain with love because I know all too well how it feels to be all alone in this world."
Johnson says the past couple of days have been nerve-wracking, worried about her son's recovery and Sammy's state and whereabouts.
At first she thought Sammy might commit suicide or that law enforcement would end the standoff on Tuesday in the loss of Sammy's life.
"Neither myself or Cody could stand by without reaching out to his cherished friend," said Johnson, who adds that now is the time to "repair these two boys. They are not disposable. They matter to me."
She says that Cody doesn't want to press charges. That he plans on trying to have the charges dropped completely and if that's not possible, then charges to be reduced to lowest terms.
"I hope and pray for a totall recovery for Cody and total mercy on Sammy," said Johnson. "This tragic event is bigger than these two young men. It is a reflection of what happens when we damage and break our children."
Follow us on Twitter here | Like Half Moon Bay Patch here | Sign up for our daily newsletter | Blog for Half Moon Bay Patch here


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The Taipei Times reports the firm is seeking a $500 million price.
Owned by Jimmy Lai — Hong Kong's version of Rupert Murdoch and a vocal critic of Beijing — Next's foray into local TV broadcasting was reportedly hemorrhaging cash, according to the Times.
Bear in mind that the company does a lot more than just the Taiwanese animations that bloggers are so fond of.
While Lai initially attempted to sell only that division, he was advised to sell the entire firm to get a higher asking price, the Times said.


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|Grand Theft Auto V
|Eclipse Boulevard, West Vinewood
|Refers to:
|Whisky a Go Go
Tequi-la-la is a nightclub in Grand Theft Auto V. It is located at the intersection of West Eclipse Boulevard and Milton Road in West Vinewood, Los Santos. It is based on the rock n' roll nightclub Whisky a Go Go, which is located on Sunset Boulevard in West Hollywood, California.
The bar is comprised of three main areas:
- Main floor : Features the bar itself at one end with a stage at the other and a small dance floor between the two.
- Second floor : VIP lounge and technical/DJ area.
- Basement : Game room with a pool table, QUB3D arcade and darts board.
It is featured in the Strangers and Freaks side mission Vinewood Souvenirs - Willy, where Trevor Philips must collect a gold tooth from Willy, the bassist of Love Fist who are playing there.
After this mission, the bar is available for purchase for $2,000,000. Once bought, it generates a weekly profit of $16,500. The player can then choose to participate in side missions such as picking up alcohol or defending the establishment from Gang Attacks.
Owner of the most legendary rock club in town!
Hi Mr. De Santa/Philips/Clinton,
My name's Cody and I'm the club manager at Tequi-la-la. Just throught I'd reach out and say hi to my new boss! You've bought a piece of history, dude. Pretty fucking cool.
Anyway, I'll keep you in the loop.
Rock on,
- Tequi-la-la.
- Tequi-la-la's marquee was seen in the first trailer for GTA V.
- The interior is only accessible in Vinewood Souvenirs - Willy. The front and back doors are locked for the rest of the game, even if the establishment is bought.
- The marquee advertises Love Fist playing "for one night only," although the sign never actually changes for the rest of the game.
- According to a certificate found on the wall in the entrance booth at the front of the establishment, Tequi-la-la opened on January 1, 2012, although strangely if you take the Vinewood Star Tours Bus, the Tour Guide mentions Tequi-la-la being opened in 1983.
- If purchased, Tequi-la-la will take 122 weeks to turn a profit over the initial investment, not counting bonuses from side jobs.
- When on a Vinewood Star Tours, the tour guide will mention that the club used to be a restaurant owned by an unknown mafia family in Los Santos. This is probably a reference to the now nearly defunct crime family, the Los Angeles crime family, seeing that one of its members owns a pizzeria in the city of Westwood.


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511 Lexington Avenue at 48th Street, Midtown East, New York City, NY 10017 – Show map
Excellent location – rated 9/10! (score from 582 reviews)
Rated by guests after their stay at The Lexington New York City, Autograph Collection®.
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The Standard, High Line New YorkLatest booking: 15 minutes ago There are 13 people looking at this hotel.
The Waldorf Astoria, a landmark hotel on Park Avenue in Manhattan, offers luxurious rooms with marble bathrooms, just blocks from upscale shopping on 5th Avenue.
Score from 2626 reviews Very good
Hilton Garden Inn Central Park SouthA 7-minute walk from Central Park, this Manhattan hotel features an on-site fitness center and rooms with city views. Times Square is just over half a mile away.
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Just minutes from Times Square and Broadway theaters, this New York City hotel offers Wi-Fi access and rooms with plush bedding and a flat-screen TV. Central Park is a 5 minute walk away.
Score from 2051 reviews Good
Featuring a rooftop bar, this hotel is in the Midtown West neighborhood of Manhattan, just a 10-minute walk from Times Square. Wi-Fi access is provided free of charge to guests.
Score from 39 reviews Excellent
Location was great, staff was friendly, room was cute and clean
There were some type of insects, probably bed bugs in our bed at night, I woke up with itching mosquito like bites on my legs. It didn't bother me too much though since New York does have a problem with bed bugs
Loved location! Daughter had a blast ..not much in hotel. .comfy room..
Rushed check in..
Our room was amazing, the bed was so comfortable and the facilities in the room were top notch. We loved our stay and wished we could have been there longer!
Could not say a bad thing about this hotel!
Nice staff. Upgraded us to larger room. Nice location. Fun art all through hotel. Busy lounge area with funky chairs and nice environment.
Is near to Times Square, Grand Central Station, UN and the Chrysler Building
Location and cleanliness
Room was too small for 2 people
Atmosphere in a Lobby was great
Room 405 had a view if the generators, very expensive hotel bar, old hotel with a new face
I loved the location, the service, the amenities, the cleanliness. The prices were worth the value. Juan the bellman was extremely helpful & helped me get to a room with a better view. All staff were kind and courteous. Will definitely return again with the family!!! Also very close to subway 6, great way to travel around the city and save.
I liked everything, no negatives.
Great location Smart lobby refurbishment feels very contemporary Lobby wi fi is free
Bedroom wi fi is not free Bedroom is small Bathroom small and fittings are old Pricey
Location, service,
Cleanliness of the rooms and the excellent front desk service.
Nothing everything was gross
The sleeper sofabed had used sheets on it. But after a phone call, the staff quickly supplied clean sheets.
The hotel staff members are horrible. Very noisy hotel , the A/C was noisy and not clean enough
It is the best hotel and the location it is near from any where such as times square and station for swbe way you can go any way by 2$
Superb Location
The location was great for the price! Also the valet parking attendants were very nice and informative.
One of the fitted sheets were stained. The ac didnt work as well as I expected. Breakfast was kinda expensive.
Good location, clean, friendly, helpful staff, overall good atmosphere. You won't be disappointed here, but also don't expect too much.
Free Wifi only in lobby (it's just a small thing, but that makes it not less annoying), small room, dirty window blind, not much of a view.
Location was excellent. Room was quiet and well equipped. I would consider staying there again.
Not being able to use wifi for free in my room was a disadvantage.
Noisy Storage of luggage not free Limited amount of products in the room (1 small bottle of shampoo for 2 people-3nights..)
Good Location, and our suite was very large with balcony and great views. We were given two rooms together which was very convenient for the family.
We had booked for 3 people for the suite, but the bedding for the sofa bed had not been changed. We complained but it took over an hour for the hotel to send up clean linen. Also free coffee provided on first night, but no policy to replace this for subsequent nights. We complained and hotel gave us some vouchers as compensation.
Great location
Bathroom was outdate. No proper towels.
Attractive lobby artwork in lift etc. Allowed early check in. Location good close to 5th avenue and Times Square and bus routes.
Charge to keep luggage in storage for two hours. Never had to do that in any hotel anywhere in the world before.
Nice room and staff
No refrigerator
Location was excellent
The room was too small & the room servive was disappointing
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Yorkton Council had a look at its Land Fund Budget Monday.
In making the presentation to Council Director of Finance Lonnie Kaal said the Land Fund is about funding "growth", adding that means "infrastructure required for growth."
In "looking at the big picture, long term" financing potential growth will be significant, said Kaal. She noted there are currently some 1,700 acres within the city which could be developed, with an estimated infrastructure cost of some $90 million, a cost which could stretch out over the next 25-years.
While substantial costs Kaal noted "the Land Fund doesn't cost taxpayers any money," and thus has "a budget separate from the City budget."
The 2014 Land Fund Budget presented will see some $15,826,075 invested in infrastructure to serve a number of projects.
Kaal said in most of the projects the costs are recouped with the sale of the land for actual development.
The one project which is something of an anomaly is infrastructure for the lands where the new Parkland College Trades and Technology will be built, said Kaal, explaining the land was donated by the City to the college project.
If the City had sold the land to the college (20 acres @ $180,000 = $3,600,000), the proceeds would have paid for the entire upgrade project. Since the land was gifted, the general tax base is funding $2,745,000 from drainage, roads and waterworks budgets with the remaining $755,000 being paid by the College ($320,000 development charges & $435,000 direct servicing agreement), detailed a report circulated to Council.
With the funding from the City's general capital, detailed in the 2014 City Budget, the near $16 million in expenses will be balanced by development charges on land serviced, said Kaal.


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RINGGOLD, GA (WRCB) -- A two year battle between Catoosa County, a businessman and his upset neighbors has finally come to an end. A judge has ruled in the case over whether a Ringgold man's tree service, that's run out of his house, is a nuisance and goes against zoning ordinances.
A superior court judge made the final decision this week saying Craig Burchfield can continue operating ASAP Tree Service in his yard even though it's in a residential zone. As you could guess, not everyone is happy with the outcome.
For the last two years, people living along Dietz Road have complained to the county on Craig Burchfield's business ASAP Tree Service saying it's loud and it shouldn't even be there.
"It's not zoned for that and that's the law," neighbor Jeffrey Hutchins told Channel 3 in a previous interview.
"I continue to get calls from zoning about problems. Sometimes it's noise. Sometimes it's starting work too early," ASAP Tree Service Owner Craig Burchfield told Channel 3 in a previous interview.
Several months ago zoning officials had him put up an eight foot fence to take business out of eye and ear shot, but neighbors say it wasn't enough.
"There's been a lot of noise, dust that kind of stuff, dump trucks, logging, chainsaws," neighbor Ryke Merrill said.
After getting constant complaints, Catoosa County took Burchfield to court for a judge determine if the tree service was a nuisance or "home occupation business."
The final decision this week. The business can stay open, but with some limitations like sawing between 8 a.m. and 5 p.m. only up to 10 hours a week and behind the privacy fence. No outdoor advertising except the truck and sign in the front yard. Also, Burchfield has to use the back entrance for heavy equipment or selling firewood to the public.
"If he does what they've asked him to do, I appreciate that. That's neighborly, but at the same time, why are we only stopping at the noise ordinance? Why aren't we going after it being a business," Merrill said.
Several neighbors Channel 3 talked to agree with Ryke Merrill, saying their biggest problem is the constant foot traffic.
"You start adding other guys in here that you don't know and I've got a 15 year old and a 10 year old. I get a little concerned," Merrill said.
Merrill put up a privacy fence, while another neighbor posted surveillance cameras.
Burchfield didn't want to go on camera, but says he's just glad for it to all be over with. He hasn't started back to work yet, even though the cease and desist order was lifted a few days ago.
Meanwhile, neighbors say they're disappointed with county, and don't think the saga is over.
900 Whitehall Road
Chattanooga, TN 37405
(423) 267-5412
WRCB Jobs EEO | FCC Public Files


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I have never minded spending any amount of time when a patient needed me or to do anything that bettered patient care. I am sure that none of you have ever minded being awakened at night by a patient who was ill and needed attention: hey, we're ObGyns. I would not object to spending any amount of time on the conversion to an electronic medical records (EMR) system if I thought it would really benefit patient care. But I am convinced that it does not.
I knew that I would have problems with our new electronic medical record (EMR) system on the first day of training. The initial training was conducted by a programmatic, not medically trained "yuppette" from the IT Department, who extolled to a 60-year-old Mac user the wonders of the EMR system: you should right click here, single click there (oops, don't double click!), and then enter some esoteric bit of medical history.
Copyright © 2000-2012 Quadrant HealthCom Inc., Parsippany, NJ, USA. All rights reserved. Unauthorized use prohibited.
The information provided on FemalePatient.com is for educational purposes only.
Use of this Web site is subject to the medical disclaimer and privacy policy.


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COLORADO SPRINGS, Colo. (AP) — Atmel Corp. has laid off 140 permanent employees in Colorado Springs in its latest round of cuts due to weak economic conditions.
Nineteen-year Amtel programmer Barry Pettis tells The Gazette the layoffs affected hourly workers as well as salaried managers (http://bit.ly/W5ps2H ). The company, based in San Jose, Calif., makes touchscreen microcontrollers.
Atmel's investor relations director, Peter Schuman, says the cuts Tuesday and the layoffs of 60 temporary workers in mid-December came because the company's Colorado Springs plant has been operating at about 70 percent capacity for more than a year.
The plant now has about 1,100 employees.
About a year ago, the Colorado Springs City Council approved retroactive tax breaks that cut the company's tax bill by $339,070 on $25 million in capital spending planned by 2015.
Information from: The Gazette, http://www.gazette.com


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"The loyalty of patrons, audience getting involved, passionate performers, a good sound system, awesome outfits." Byron Bay born Melbourne DJ TigerFunk (known to his parents as Ezra Harvey) has a simple checklist when it comes to a good club night. Currently calling Bimbos home on a Tuesday night, Harvey is not a man afraid to enjoy his night as much as his audience. "For me it is mostly my jumping up and down. Just getting excited and translating that into the music and movement. Vocalization as well, if you can get away with it. Whooping and screaming."
That being said, Harvey is far from what could be called a self-indulgent DJ. Though he is passionate about the music he spins, he admits, "It really depends on who you are dealing with", when it comes to planning his set. Rather than being holed away behind his decks, he reveals, "I am always trying to find some way to include them, to the point that when it is dead, I will actually walk around the room and undertake a survey of what people are actually into. Then I can play that for them."
Though prepared to go to extreme lengths to ensure that the dance floor is buzzing, there are clear limits as to how far Harvey will go to tailor his evening for the individual. With an admirable honesty, he reveals, "I hate when people request songs, but it is ok when people request genre. I am a lot more willing to give back to them when I know what people want to hear. I hate it though when people hear their one song and then head off the dance floor. I love it when people are like 'have you got any dirty, phat, tech house?' I am just like 'yeah! I like that too!'"
While it may at first seem a little odd that the crowd pleasing DJ refrains from going the extra mile for the individual, upon closer inspection, it becomes apparent that the logic behind his slightly closed approach is more than understandable. He confesses, "I would prefer to play something that people don't know, not for the education factor but for the creation of a full feeling," before offering "Do you want to hear the whole theory?"
His candid approach is irresistible to any journalist. Rather than closely guarding his secrets, Harvey is willing to entice further audience participation by explaining at length his expectations. "When people go out, there are two things going on. One, people who go to hear what they already know. The cheese factor. The classic example is Michael Jackson, but it can also be what is played on the radio at the moment. What that does, for an audience member, for me, when I go out, it transports me back to the first time I heard that or a moment I shared it with my friends. So I am sort of exited from the moment. Whereas, if I go somewhere and hear something I have never heard before then there is a greater chance that I will be transported into a new moment. I could make a new memory. I can just be caught up in the now and create a new memory. Forging new paths instead of treading old."
Given that as a DJ, he is far from wishing to be an educator, what is it that the introduction of new music feeds him? "When you get that synergy between a crowd and performer, when it is totally there, in the music. I don't get that so much with older music, everybody knows how it goes. Whereas if it something they are not already open to, they find themselves being elevated."
While he describes himself as a "genre whore, I will pretty much play anything", he admits that his adversity to the song request could also be related to the fact he has "had some horrible requests. Anything from Matchbox 20 to god knows what. You know, when you are playing dark ass breaks and someone requests that, you obviously have to question mark it. You just go 'What?!?' I just wish people would get creative if they are going to be that stupid!"
With his rules clearly defined and his expectancies of an evening set high, Harvey has proved himself to be a defining feature of the Melbourne scene since his arrival some six years ago. Given that Melbourne has access to everything, the question remains, how have people responded to his "genre whore" attitude? "It is not so much about the genres, it is more about the energy of it all. People know they will get an up vibe. It really depends on how open people are, but lots of people want to operate on that frequency."
Tigerfunk [AUS] plays the Best Of Both Sides Festival at Lucky Coq, which runs from Tuesday April 19 until Monday April 25.


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AC Lighting Inc. has officially announced that it has been appointed as the North American distributor for Artistic Licence, the UK-based developer of specialist control products and test equipment for the entertainment lighting industry.
In addition to maintaining a significant stock of a wide range of Artistic Licence products, AC will be offering full technical support and system design services.
Bob Gordon, president and CEO of AC Lighting, sees the addition of the Artistic Licence product range as a natural progression: "Here at AC we are all about providing people with solutions to their problems," Gordon explains. "Artistic Licence have won numerous industry awards for their intelligent and creative product line, and we see their range as providing inventive solutions to number of issues".
"We've had a very positive relationship with AC Lighting Inc over the years, both in the development of new products and in the application of existing ones," adds Wayne Howell, managing director of Artistic Licence. "However it's now time for us to have a more concentrated focus on the North American market and cement our relationship. AC Lighting, with their extensive experience in selling and supporting high technology products, are the ideal partners."


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Uncover your inner self! Develop your strengths and attain your dreams and desires with the help of the stars.
"Very insightful, brings back memories of some very happy times. Wish I could have had these insights earlier on, I may have made better choices. Well, as they say all things are going as planned. :)"
-- Andy, United States


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- Home
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MARTIN GARCIA, LOVE AND PRIDE, WINNER: "The instructions were to let her break and
not fight her, just let her be happy. That's exactly how the race turned out. I let her break, sat, then when it was time to go she just finished the job. I'm very lucky to ride this beautiful horse and I will pray to see if I can stay with her."
ROSIE NAPRAVNIK, JOYFUL VICTORY, SECOND: "She's a filly I've never ridden before, but (trainer) Larry (Jones) made it clear she doesn't really like to be down on the inside. Unfortunately, we were stuck there for three-quarters of the race. But I eased my way out and the only chance I had was coming around the turn and she finished very well and she kept on very gamely. I think this is her preferred surface, based on her form. I've never ridden her. I never was on her, even in the morning."
JOE TALAMO, INCLUDE ME OUT, THIRD: "We had a perfect trip – I thought she ran really well. Just like Ron (Ellis) said, you just can't win if you're not in front on this track. It feels real good, but it's definitely favoring frontrunners today. We had a pretty good trip – I was able to get over and didn't want to move too early and she put the brakes on. I thought we had a good trip today. We're still high on her."
MIKE McCARTHY, ASSISTANT TO TODD PLETCHER, LOVE AND PRIDE, WINNER: "Exactly," when asked if she figured to be in front based on past performances. "Turning up the backside I thought Martin's horse (Via Villaggio) might come up and give her a little company, but he was nice enough to go ahead and sit right off of her.
"This filly, when she gets a chance to settle into a rhythm, she's obviously able to finish off her races. I think you saw that today. Provided everything goes well, I believe this filly and the horse we run tomorrow (Turbo Compressor in the John Henry) will stick around (Santa Anita for the Breeders' Cup)."
RON ELLIS, INCLUDE ME OUT, THIRD: "You just can't close on this track the way it is. Speed's holding, and they didn't go very fast. But it was good. We'll do better next time. It's just the way the track is now. Unless you're on the lead, you can't win."
NOTES: The winning owner is Dimitrios Katsaros of New York City who races as Green Hills Farm, Inc.


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The Lee County Sheriff's Office is currently responding to a crash on Metro Parkway just north of Daniels Parkway in Fort Myers.
The crash, involving a LeeTran bus and two other cars, shut down the southbound lanes of Metro Parkway for over an hour.
Five victims were transported to the hospital from the two cars, one of which was a trauma alert.
The driver of the LeeTran bus was not injured and no passengers were on board the bus.
The crash remains under investigation. Additional details will be posted as they become available.
3719 Central AvenueFort Myers, FL 33901Main Phone: (239) 939-2020Newsroom Phone: (239) 939-6223


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401 Water Street (left) to Contemporary Art Center (right)
Cardiff school of art and design, first gigapan experiment with a Canon G10, 88 images around 1.5 MB each
This fantasy map was created from tessellated aerial photography of the area around the New York Public Library in Midtwon Manhattan. A printed copy of this fantasy map is in the map collection of the New York Public Library. View map on my website: www.nikolasschiller.com/blog/index.php/archives/2008/06/25 /...
Every Fall for the past 33 years some of the planet's most insightful and influential design leaders have gathered to share, argue, and bond at DMI's Annual Design Management Conference. From October 5–8 we hope you will join in and explore what happens when you mix traditional approaches to design, identity, and...
The new design center close to Tokyo Midtown building. The particularity of this building is that the roof is made of one folded steel plate.
A unique store which carries many well designed products and authorized as a Japan Good Design Award Partner Shop.
A unique store which carries many well designed products and authorized as a Japan Good Design Award Partner Shop.


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Cedar - North Laguna - New ! in Laguna Beach
- bedrooms 1
- baths 1
- sleeps 4
- pool no
- hot tub no
- pets allowed no
- type Condo
- community
- rates (USD) $ 3,195 - $ 4,200 / month
vacation rental description
Cedar North Laguna 240 Jasmine Street, Unit B | Laguna Beach, Ca 92651 Nestled among art galleries, boutiques and lush flowering gardens, Cedar North Laguna is an extraordinarily tranquil and serene posh beach villa. Flowering bougainvillea and lush vines surround the corner-lot duplex property, creating a true beach villa feel. Ideally located in the much sought after North Laguna Beach area, the home is within walking distance of world class beaches and the historic Heisler Park. This brand new renovated 1-bedroom 1-bath villa occupies the second floor of the property and comfortably accommodates 4 guests in an idyllic setting. The home is immaculate and boasts stylish modern décor with high-end finishes, while still retaining the warmth of a vintage era.
The brand new, top of the line, custom gourmet kitchen is just the right size for cooking up breakfast or dinner and features a convenient circular glass modern dining table across with bar chairs to enjoy your meals and views of the hillside and coastline. Brand new Kitchen Aid stainless steel range, microwave and dishwasher are included as well as a full-size refrigerator. Plenty of natural light flows through the villa and recessed can lighting adds to the ambiance. The cozy living room comes equipped with a very comfortable sofa-sleeper and a 50" Samsung Flat Screen TV and a Sony DVD player. A touch of whimsy will be enjoyed in the room's coastal décor and a sitting area beckons with its warm natural light. Across the room is a striking work desk where guests can enjoy the complimentary wireless access. Acacia wood floors and versatile pattern shells reef, beige brushed limestone floors combine with elegant crown moldings to elevate this beach rental with style, class and flair.
vacation rental location
property availability
- dates with deals
- unavailable dates
Last modified on 09-2-2014 at 8:50 AM.
email owner view full calendar
customerservice 949-310-4161
condo rental amenities
- Comfortably sleeps 4 guests - one Queen bed, one queen sleeper sofa
- Gourmet kitchen with quality appliances and cooking/serving utensils
- Stone Flooring Throughout
- Modernized Bathroom with Plush Towels
- Ceiling Fans
- Brand-New Contemporary Furnishings
- Wireless Internet Access (WiFi)
- Total 2 Flat Screen TVs with DVD Players
- BluRay DVD Player with the main 46-inch LED TV
- Washer & Dryer
- Iron & Ironing Board
- Barbecue Grill
- Beach Chairs and Beach Accessories
- Outdoor Hot &Cold Shower
- Cozy & Private Outside Deck
- Single-Car Parking space-assigned
activities and attractions in Laguna Beach Los Angeles Area
Cedar North Laguna is located in a charming Laguna Beach neighborhood filled with flowers, ocean breezes and ocean views. The cottage is a short stroll from North Coast Highway and is walking distance to Laguna Beach.
• Laguna Beach is beautiful and sun-kissed. Play in the waters, lay on the beach, pack a picnic, shop the galleries, see working artists, visit the Pacific Marine Mammal Center or the Laguna Playhouse. Laguna's Tide Pools are a great place to see wildlife in its natural setting. Historic Heisler Park is about 1 block away as well as outstanding scuba and snorkeling beaches
• A short drive south to Dana Point Harbor offers opportunities for fishing, sailing and whale watching excursions. Stand Up Paddle Boards and wave runners are availvable for rent. Surfing at adjacent Doheney Beach is another favorite activity.
• Newport Beach is approximately 15 minutes to the North on Coast Highway.
For everyone who loves art, Festival of Arts is a can't-miss event. For over 70 years Laguna Beach has been graced with the presence of this celebratory event, now exhibiting the works of over 140 acclaimed local artists. Festival of Arts has grown from humble beginnings to become the world-famous attraction it is today. A special Summer treat is the Pageant of the Masters -- a true-to-life staging of some of the art world's most famous pieces. Paintings by artistic "masters" are brought to life by volunteer actors. Be sure to check out the tableaux vivant.
• The Festival of the Arts displays artwork by the best local artists on the grounds in Laguna Canyon. The artwork is all for sale. Summer & December seasons.
•The Laguna Art Museum is a fun museum overlooking the ocean. The permanent exhibit features artwork by California artists. Walking distance from Jasmine North Laguna.
Laguna Beach has been made famous by the MTV television show of the same name, but it still manages to retain its artsy, laid-back vibe.
vacation rental rates
- June - $4000/month
- July - August - $4200/month
- September - $3195/month
- October - April - $3195/month
Additional Terms
- Security Deposit
- Utilities: $200/month
- Cleaning Fee $150
- No Smoking, No Parties, Weddings and/or Receptions
customerservice 949-310-4161
accepted payment methods
Prior to paying a reservation deposit, always verify payment instructions by calling the phone number displayed on this listing page. By contacting the owner directly and paying by an approved method - credit card, paypal, check or bank transfer - your reservation payment will be protected up to $1,000.Learn more in our Security Center
Top things to do in Laguna Beach
- Downtown
- Surf
- Ride bike
- Kayaking
Top things to do on a budget
- Shopping
- Eat
- Golf
Top things to do with a family
- Sightseeing
- Beach Volley
- Surfing
- Movies
customerservice , owner


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