text:
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As with many cameras nestled in the niche between sub-£300
point-and-shoots and full-fledged, £600-plus DSLRs,
the PowerShot G1 X is pure, drooling goodness when
you take it out of the box. It's got a massive 1.5-inch,
14.3-megapixel sensor and the same DIGIC 5 processor found in
Canon's latest digital SLRs. Couple that with 1080p video, a solid
body that takes its design cues from the stalwart days of film, and
you're left wondering: What's the catch? Full review
The 22.3-megapixel Canon EOS 5D Mark
III captured some of the cleanest images I've seen from a DSLR
when shooting in low light at high ISOs. That's no small feat.
Cameras such as the 5D Mark III's predecessor -- the 5D Mark
II -- and the 16.2MP Nikon D4, are designed as low-light
assassins, with large, full-frame sensors approximately the same
size as a frame of 35-millimeter film.
That the Canon 5D Mark III does so well in so little light is
all the more impressive because the pixels on its 36 x
24-millimeter CMOS sensor are smaller than those in the
lower-resolution D4. Tinier pixels have less surface area for
absorbing light and should, theoretically, stumble more easily in
the dark. Not so with the 5D Mark III.
Full review
Canon's PowerShot SX150 IS superzoom offers full
manual shooting controls as seen on pro SLRs, and lets you
capture them using a 14-megapixel sensor. But can one particular
weak spot detract too much from the attraction of these
The SX150 isn't the smallest compact by any means at 113 x 73 x 46
mm, but its ergonomic exterior feels robust, without being heavy.
The rear features well laid-out menu controls and a 75mm (3-inch)
LCD screen. While a decent size, the image quality of the screen is
average at best, and undermines one of the camera's most impressive
features. We'll come back to this shortly.
Shooting pictures is quick and easy, as buttons are exactly
where you'd expect them, so there's very little design-wise to stop
you from whipping the camera out in an instant and capturing the
moment. A dedicated video recording button features on
the back for quick access to shooting video, and the long
12x zoom lens on the front is quiet -- only in almost-silent
situations will its operation be audible in any videos you
take. Full review
If you're looking for a high performance camera with great image
quality, you should get a digital SLR, right?
Well yes, DSLRs are top-drawer picture-takers. But they're bulky
and they weigh a ton. They also aren't exactly the most discreet
cameras out there -- put a long zoom lens on a DSLR and try to take
it to a pro sporting event or a rock concert and, unless you have a
press pass, you'll be sent packing.
A far less conspicuous and more portable option is the Canon
PowerShot G12, a compact, consumer-style 10-megapixel camera with
the photo skills of a serious pro model. Full review
Panasonic's Lumix DMC-GF2 camera succeeds and replaces the
original GF1 model (a camera so impressive this writer bought one
after returning a review sample). So what has changed within the
year that separates the two? And more importantly, is this smaller,
lighter successor worthy of upgrade money?
The GF2 is a Micro Four Thirds camera, which in a nutshell means
it offers DSLR-like functionality and interchangeable lenses, but
in a body more akin to a large compact camera. The original GF1 was
one of the first models to use this compact new system, and it did
so admirably. But the GF2 aims to take things further. However,
when initially testing the new model, it's clear Panasonic knew
it's first-born was an out-of-the-box winner, because little has
changed internally. Full review
Mobile retailer Phones 4u has launched a contract that lets customers upgrade their handset as often as every six months, without egregious upfront costs »
Inspired by twitchers' field notes, Dutch designer Ruben Pater, 29, created the Drone Survival Guide, which illustrates 26 types of UAV, drawn to scale »
Wired.co.uk reviews the best and cheapest tablets for students on a budget »


text: Whitney-Houston By May 13, 2013 8:57 AM Share on Facebook Share on Twitter Category: Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! More from 102.7 KORD What Should I Eat at the Benton Franklin Fair? [SURVEY] Watch the Video From the 2014 Black Widow Mud Run! Love Those Kord Branded Listeners! Lots of Fun at the KORD Booth! Come See Montgomery Gentry + John Michael Montgomery at the Fair TONIGHT! Best of the Web

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LP Monday Message: See Sarvis run!? 2013 list
Posted on Sep 9, 2013
Dear Friend of Liberty,
Rob Sarvis,
LP Virginia
Candidate for Governor
Robert Sarvis is getting so much publicity by running for governor!
He's a perfect example of how you can amplify your voice for liberty a thousand times by running for office!
From the Richmond Times-Dispatch to Fox News to Public Radio, Sarvis is there. He gets cheated out of the debates, but he's out there in other ways. Just take a look at the list of 111 stories on his media page. Of course, the 37 campaign events he lists are impressive too.
If the Libertarian Party of Virginia had to pay for all of that publicity, instead of getting it for free from the candidate, it would cost tens, if not hundreds, of thousands of dollars.
Now for the full disclosure: The Sarvis for Governor campaign had to pay more than $25,000 just to get on the ballot. And I believe that Sarvis contributed more than $15,000 of his own money for that petition drive.
Ouch! That's a lot of money out of his pocket, plus a lot of time taken away from his family!
But that's the kind of dedicated heroes we have running for office in the Libertarian Party. People willing to give their time and money to make America a freer place for themselves, for their families, and even for the stranger that may never even know about it but will reap the benefits of liberty.
Click here for our complete list of candidates in the 2013 elections. Please send a note to email@example.com if you see anybody missing from our 2013 list.
I think the number one thing you can do to promote the Libertarian Party and its principles is to run for office. Any office! Please click here to submit your name as a possible future candidate.
You don't have to work as hard as Robert Sarvis. We'll help you find an office that fits your time and budget.
Texas has the earliest deadline for the November 2014 elections (December 9 of this year), so if you're a Texan, submit your name today, before it's too late!
If you'd like to donate to the Libertarian Party, that will help us recruit and promote more candidates. The Libertarian National Committee often pays to get state parties on the ballot so that their candidates don't have to pay for ballot access out of their own pockets.
Please run for office, or donate today. $15,000 anyone? $1,500 or $150 or any amount helps.
Thank you for all that you do.
Wes Benedict
Executive Director
Libertarian National Committee


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Port St. Lucie, FL (Sports Network) - Allen Craig's RBI single in the eighth inning proved to be the difference in St. Louis' 3-2 victory over the New York Mets on Thursday.
David Freese had a solo home run and Adam Wainwright contributed a run scoring single in addition to his 4 2/3 innings of work in the start for the Cardinals. He struck out three and gave up two runs on three hits.
New York starter Jeremy Hefner struck out four and surrendered two runs on five hits over five frames. Matt den Dekker's two-run scoring triple in the fourth inning accounted for the Mets' only runs.
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Arizona has the toughest Sheriff in the Country, and now the toughest Marijuana DUI laws.
Driving under the influence of marijuana is illegal in Arizona under Arizona Revised Statutes (Section 28-1381(A)).
In Arizona, motorists are prohibited not only from driving while impaired by the effects of marijuana, but also "while there is any drug defined in section 13-3401 or its metabolite in the person's body." Recent case law exists that allows for prosecution under this law in Arizona, even if the motorist was not driving impaired. That is, if the only substance found in their bodily system was residual trace compounds that were present due to Marijuana smoked or ingested weeks prior to the DUI stop, they may still be prosecuted.
Frequent Marijuana users, especially Medical Marijuana users, have been known to tolerate anywhere from 2 to 5 times of what would be considered the legal limit of Marijuana in some of the states that have legalized it in some fashion, and still drive without impaired function in driving skills.
We provided a post post on this ruling several months ago. This is refresher and update on the topic since the ruling could have broad impacts throughout the country. A US Supreme Court ruling that would hold this decision in favor of prosecuting the non-impaired motorist, could potentially have serious consequences not only for Arizona residents, but also for people from out of state who are driving to or through Arizona and used marijuana a month before their trip. We believe that the defendant is appealing the case to the Supreme Court, but there is no word on whether the court has decided to hear this case as of yet.
A first time marijuana DUI offense can be punished by up to six months in jail, as well as with a mandatory substance abuse program and the requirement that you install an ignition interlock device on your vehicle. If convicted of only driving under the influence of marijuana (as opposed to marijuana and alcohol), your driver's license will also be revoked for a year.
The active ingredient in marijuana is the drug THC. Unlike blood alcohol tests, a blood test for marijuana cannot determine how intoxicated or impaired you might be from the THC. THC is rapidly metabolized in the blood stream and turns into about eighty different molecules called metabolites. These metabolites are stored in the user's body fat. Some of them have a half life of twenty hours, but others can take 10-13 days to be eliminated from the body. When a blood test is taken, certain non-active metabolites may show up on the test. Anecdotally, some heavy marijuana smokers have reported positive test results well over a month after stopping smoking.
Earlier this year in the case Arizona v. Shilgevorkyan, an Arizona appellate court ruled that any motorist with any metabolite or marijuana in their bloodstream could be convicted of driving under the influence of marijuana. The defendant had been stopped for speeding and unsafe lane changes and agreed to take a blood test. One metabolite, Carboxy-THC was found in his bloodstream.
The defendant argued that it was not "the" metabolite referred to in the statute. His attorney put forward an expert who testified that this metabolite was not psychoactive and could take 4 weeks to leave the body. The superior court agreed with him, but the State appealed. The appellate court looked at the legislative intent of the statute and determined that the statute intended to outlaw any of the metabolites into which THC metabolizes.
The medical marijuana bill barely passed in Arizona--it was defeated in 12 out of 15 counties and as the case described above shows, Arizona continues to penalize drug use very harshly even if it happened in the past.
If you are arrested for a DUI involving marijuana or another marijuana-related offense, you should retain an attorney knowledgeable about these types of cases to defend and protect your rights. Contact The Law Office of James Novak at 480-413-1499 for a free consultation.
Additional Resources:
• Arizona Drug DUI Laws
• Arizona Drugs Defined Under Criminal Code
• Mesa AZ Police Department
More Blogs


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Data Centre > Servers
VMware EMC partner Cisco inks reselling deal... with Simplivity
Exocet for EVO: RAIL?
Docker's VMware tryst is about giving sysadmins the whip hand
VMworld 2014 The time has come to beat cloud upstarts into shape
EMC to toss Avamar and other code into its VMware's EVO boxen
Phoenix servers used in elastic cloud storage appliance will rise again
VMware's MARVIN emerges as 'EVO' for branch offices and web-scale rigs
VMworld 2014 Converged infrastructure appliance made by Dell, Fujitsu and EMC. Yes, EMC
BBC goes titsup: iPlayer to News websites down – Auntie working to fix it
Updated Did DDoS attack on Sony kick Beeb TV offline?
Shoot-em-up: Sony Online Entertainment hit by 'large scale DDoS attack'
Games disrupted as firm struggles to control network
Your move, sucker! Microsoft tests cloud gaming system that cuts through network lag
Back to the future with DeLorean software
Silicon Valley jolted by magnitude 6.1 quake – its biggest in 25 years
Pics Did the earth move for you at VMworld – oh, OK. It just did. A lot
Sony DENIES PlayStation Network WOBBLES despite gamer GRIPES
Updated Claims of a DDoS attack swell online
Red Hat: ARM servers will come when people crank out chips like AMD's 64-bit Seattle
LinuxCon 2014 Standards to lift data center boxes out of device doldrums
Oracle reveals 32-core, 10 BEEELLION-transistor SPARC M7
New chip scales to 1024 cores, 8192 threads 64 TB RAM, at speeds over 3.6GHz
US regulators OK sale of IBM's x86 server biz to Lenovo
Now all that remains is for gov't offices to ban the boxes
Flash to the Max: HGST, NEC ink SQL Server appliance deal
Reference architecture for PCIe flash cards
Chinese Bitcoin farms: From scuzzy to sci-fi
Roaring fans to liquid baths, China's cryptocurrency rigs are serious business
Dell The Man shrieks: 'We've got a Bitcoin order, we've got a Bitcoin order'
$50k of PowerEdge servers? That'll be 85 coins in digi-dosh
Supermicro adorns servers with bright and shiny ULLtraDIMMs
Faster flash for speedier servers
Whoops, my cloud's just gone titsup. Now what?
No email? No CRM? No Daily Mail iPad edition? You need a plan
Cisco to reveal UCS for small businesses
New fabric interconnect for up to 15 servers emerges
Rackspace touts cloudy, single-tenant OnMetal servers to world+dog
Pricing revealed for dedicated boxes that provision like clouds
Sysadmin Day 2014: Quick, there's still time to get the beers in
He walked over the broken glass, killed the thugs... and er... reconnected the cables*
SAP: It was our Big Data software wot won it for Germany
Vorsprung durch grossendatatechnik, as we like to say in Germany
Manic malware Mayhem spreads through Linux, FreeBSD web servers
And how Google could cripple infection rate in a second
Kaboom: Delayed patent bomb hits SAP in the Q2 profit
Hey ho, more cloud sales it is
Speaking in Tech: How I was outsmarted by my LG smartwatch
Podcast Plus: Google's new hired hacker, 'Princess' Parisa Tabriz
Donahue grabs Atlantis double crown: Takes CEO and pres titles
Virtual software firm's former CEO goes upstairs
Virty server bones thrown: Gartner mages see Microsoft rising
What a shock, VMware in the lead
Mobile, cloud, social? Data? Nadella strings sexy words together
Comment Long-winded memo makes us miss Steve Ballmer
Microsoft's new 'Adam' AI trounces Google ... and beats HUMANS
Asynchronous design crucial in giving 120-machine cluster the edge in neural-network wars
China clears Lenovo's slurp of IBM server biz
Firm reckons deal will close this year, despite US national security concerns
IBM promises mainframes on tap as SoftLayer lands on London
Unbelievable... Chessington's nowhere near London
Aereo presses pause on 'tiny antenna' TV-streaming service
Vows to fight on after US Supreme Court ruling
Windows Server 2003 end of life: Plan your WS2012 migration now
Webcast Watch this guide
Unisys makes a tilt at converged infrastructure and containerisation
Reference platforms on the way to allow other server-makers to spread the love
Most read
- JLaw, Kate Upton exposed in celeb nude pics hack
- Google flushes out users of old browsers by serving up CLUNKY, AGED version of search
- China: You, Microsoft. Office-Windows 'compatibility'. You have 20 days to explain
- GCHQ protesters stick it to British spooks ... by drinking urine
- Twitter declines to deny JLaw tweet scrubdown after alleged iCloud NAKED PHOTOS hack


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It's Sonic and the SEGA All-Stars, racing - but this time it's transformed.
VideoGamer.com Score:8
Our Verdict: Sonic & Sega All-Stars Racing Transformed mixes some wonderfully loving nostalgia and ambitious design to create a credible Mario Kart alternative.
Latest Articles for Sonic & All-Stars Racing Transformed
Aliens: Colonial Marines shipped 1.31 million copies by March 31, 2013
SEGA shipped more units of Sonic & All-Stars Racing Transformed.
Team Fortress 2's Heavy, Pyro and Spy race into Sonic All-Stars Racing Transformed on PC
Football Manager and Shogun: Total War characters along for the ride, too.
Sumo Digital: Nintendo could learn from Sonic & All-Stars Racing Transformed
Executive producer thinks Nintendo could take a leaf out of his latest racer for Mario Kart.
UK Video Game Chart: Black Ops 2 is No.1 with biggest launch of 2012
The fourth biggest week one total of all time in the UK.
Heads-up: New games out this week (November 16)
A look ahead to this week's new releases, which include Black Ops 2 and F1 Race Stars.
Sonic & All-Stars Racing Transformed Euro Limited Edition detailed
Includes OutRun Bay track, Metal Sonic Mod Pack and more.
Related Topics
Sonic & All-Stars Racing Transformed is now free to play on iOS & Android in Article Comments
VIP Pass is free to those who already bought the game.
PlayStation Plus - Your December Instant Game Collection in Article Comments
Guacamelee and Sonic All Star Racing are quality, you gotta love PS Plus
UK Wii U eShop content and pricing in Article Comments
It's not as perfectly responsive as I would of liked it to have been, but so far I have experienced no any frame rate loss/ movement stutter, whilst actually using the touch functionality,...


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Bi-Lateral Trade Agreements
Numerous bilateral agreements between the U.S. and individual nations provide a framework for expanded global trade. The American Meat Institute supports free and open trade for the mutual benefit of nations. At left is a country-by-country listing of key bilateral trade agreements of importance to the U.S. meat and poultry industry.


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The UN Global Compact's environment principles are derived from the Rio Declaration on Environment and Development.
The three principles are:
The world is today facing unique and daunting environmental challenges. These include climate change; an emerging global crisis in water availability and water pollution; record loss of biodiversity and long-term damage to ecosystems; pollution of the atmosphere; waste production and disposal; impacts of chemicals use and toxic substance disposal; damaged aquatic ecosystems; and deforestation and land degradation.
In recent years, increasing numbers of companies have adopted broad-based strategies and policies to manage the widening array of risks, and in some cases opportunities, presented by these environmental challenges. Companies that pursue such sustainable approaches can generate benefits from the following:
While more and more companies have embraced environmental sustainability as a management imperative, it is also clear that even more comprehensive strategies and actions will be required if business is to reach its full potential with respect to global and local environmental challenges.
In addition to its core environmental principles, the UN Global Compact is focusing on two of the most critical — and related — environmental issues of this century: climate change and water sustainability.
In this regard, participants are encouraged to join the following engagement platforms:
UN Secretary-General Ban Ki-moon has repeatedly stressed the critical importance of sustainable energy, and is mobilizing key constituencies from all sectors of society in a major global initiative intended to shape the fundamental policy and investment decisions needed to put countries on a more sustainable energy pathway over the next two decades. This new global initiative, Sustainable Energy for All, will engage Governments, the private sector and civil society partners to achieve three major targets by 2030:
In support of the Secretary-General's initiative, the Global Compact has developed A Global Compact for Sustainable Energy: A Framework for Business Action, which was launched at the Private Sector Forum 2011. The Framework aims to motivate and guide business engagement and action in support of the initiative. In keeping with the initiative's 2030 targets, the Framework identifies how companies can have the most significant impact – through their core business operations as well as product and service development; through social investments and philanthropy; and through advocacy and public policy engagement. The Framework will be further developed ahead of the UN Conference on Sustainanble Development (Rio+20). Efforts are focused on defining, on an industry-by-industry basis, the actions that the private sector can and must take to realize the Secretary General's vision and to mobilize companies around the world.
The United Nations Environment Programme (UNEP) produces a range of training materials for decision makers in government, industry and business, and local communities.
Lila Karbassi
UN Global Compact Office
karbassi (at) un.org


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Does leaving an attachment (specifically my Woods belly mower) in the raised position when the Cub is parked place any added strain on the TC components (seals, etc.)? Is it desirable to lower the mower when the Cub is parked or does it make any difference?
Unrelated to the above subject, I have been out of touch with the forum for a week due to no internet service at my farm and I find that upon my return that there seems to be a significant delay when I am posting a topic. The delay is from the time that I click on "submit" till it goes to the next screen. I am wondering if any one else is experiencing such a delay, or might this be an issue with my computer. Thanks, Thiggy


text:
- Rio Tinto gets Alcan
Rio Tinto says its offer for Canadian aluminium company Alcan has been successful. It has received… 24/10/07 07:10 CET
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US investment bank Merrill Lynch has revealed that in the third quarter it had to write down 5.5… 24/10/07 07:10 CET
- Cute and flexible cars on show in Tokyo
Facing falling sales in their home market, Japanese car makers are trying all kinds of strange and… 24/10/07 07:10 CET
- Foretaste of criticism for Turkey
Ahead of the European Commission's annual report this November on progress towards EU membership… 24/10/07 07:10 CET
- Parliament rewards film which gives EU a slam
The Parliament has applauded a Turkish contribution towards European cinema. Fatih Akin's The Edge… 24/10/07 07:10 CET
world news
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Demonstrations by thousands of Venezuelan students against planned changes to the constitution… 24/10/07 07:10 CET
- Turkey gets Iraq backing over PKK crisis
As Turkish troops mass on its northern border, Iraq has promised to close the offices of the… 24/10/07 07:10 CET
- Beirut deputies living in high-security hotel
They live quite literally in the dark – 40 deputies from Lebanon's anti-Syrian parliamentary… 24/10/07 07:10 CET
- Million flee homes as wildfires rage across California
Nearly one million people are reported to have fled their homes in southern California as more than… 24/10/07 07:10 CET
- Kurdish fears of Turkish offensive rise
Villages on the frontline of a potential war between Turkey and Kurdish rebels lie empty, except… 24/10/07 07:10 CET
- EU hopeful after Iran nuclear talks in Rome
The EU is hoping for further talks next month on Iran's nuclear programme after what has been… 24/10/07 07:10 CET
- Anna Amalia reopens in Weimar
One of the world's cultural crown jewels and UNESCO world heritage site the Anna Amalia… 24/10/07 07:10 CET
- Turkish planes pound rebel positions in northern Iraq
It has been revealed that Turkish warplanes and troops have been attacking Kurdish rebels inside… 24/10/07 07:10 CET
- Wildfire evacuations largest in California's modern history
More than 70 million euros worth of damage so far -and the wildfires are still burning. The largest… 24/10/07 07:10 CET
- TV images of "captured" Turkish soldiers broadcast
A Kurdish TV station has broadcast images of what are claimed to be Turkish soldiers being held… 24/10/07 01:10 CET
- China launches first moon orbiter
China has launched its first ever spacecraft designed to orbit the moon. The Chang'e One orbiter… 24/10/07 01:10 CET
- California wildfires rage into fourth day
Wildfires are continuing to rage out of control in California, sparking an unprecedented exodus… 24/10/07 01:10 CET
- Kyrgyzstan government quits after referendum
The Kyrgyzstan government has resigned following the dissolution of parliament and President… 24/10/07 01:10 CET
- Turkish jets attack Kurdish militant positions
It has emerged that Turkish warplanes have been attacking Kurdish rebel targets just inside Iraq… 24/10/07 01:10 CET


text:
Price AR, Xu G, Siemienski ZB, Smithson LA, Borchelt DR, Golde TE, Felsenstein KM. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science. 2013 May 24;340(6135):924-d. PubMed.
Please login to recommend the paper.
Comments on Primary Papers and News
In our comments to Alzforum on 17 February 2012, we reported our failure to confirm the data of Cramer et al. in the APPSwFILon, PSEN1*M146L*L286V (5XFAD) mouse model of Alzheimer's disease. Mice were fed bexarotene 100 mg/kg/day for up to 50 days. We found no difference between test and control mice in a standard Morris water maze test, and no significant difference in the number of Aβ deposits. We did not publish these negative results, and only suggested that further in-depth investigation was indicated. That has now taken place with additional failures to confirm using other Tg mouse models. Given such data, it is difficult to be optimistic that bexarotene will be effective in treating AD.View all comments by Pat McGeer
Phase 2A Trial of Bexarotene in Patients with Alzheimer's DiseaseView all comments by Jeffrey Cummings
Cramer and colleagues (Cramer et al., 2012) reported the rapid reduction of soluble amyloid, as well as amyloid plaques, in two species of transgenic mice. The effect occurred over a period of only a few days and correlated with improved performance on murine cognitive tests. This report elicited substantial excitement in the scientific community, as the pathway by which bexarotene exerts its effects through the retinoid X receptors (RXR) has been subject to relatively little study and might represent a new avenue of therapy for Alzheimer's disease (AD). Attempts to reproduce this work (Fitz et al., 2013; Price et al., 2013; Tesseur et al., 2013; Veeraraghavalu et al., 2013) confirm some aspects of the original report and fail to replicate others. The two studies assessing memory (Fitz et al., 2013; Veeraraghavalu et al., 2013) both showed enhanced cognition following treatment with bexarotene. All studies showed target engagement with induction of ApoE isoforms and effects on ABCA1. Fitz and colleagues (Fitz et al., 2013) showed a remarkable effect on soluble Aβ, reducing the level of Aβ oligomers by 50 percent. None of the studies was able to reproduce the reported effect on fibrillar amyloid and plaque burden. Some studies cautioned against pursuing studies of bexarotene in AD patients (Tesseur et al., 2013; Veeraraghavalu et al., 2013). The Cleveland Clinic Lou Ruvo Center for Brain Health has initiated a Phase 2A study of bexarotene in patients with AD. Patients with mild to moderate cognitive impairment or AD who have been verified by the presence of an amyloid burden on amyloid imaging are entered into a double-blind, randomized, placebo-controlled trial. One dose of bexarotene will be studied. The double-blind portion of the trial is one month in duration. The primary outcome is the reduction of plaque burden on amyloid imaging, and secondary outcomes include a variety of other biomarkers and clinical outcomes, including novel computerized assessments. The implementation of a human clinical trial of bexarotene might be viewed as premature. Given the uniformly fatal nature of AD, the current absence of disease-modifying therapies, the preliminary evidence from animal models to AD, and the large available safety database indicate that a clinical trial of bexarotene in patients with AD is warranted. Preclinical studies provide preliminary information regarding construction of human clinical trials. The high rate of non-reproducibility of preclinical outcomes (Gunawardena) and the inconsistency exhibited by the available studies of bexarotene, even when conducted by expert experimentalists, are daunting. The variability of outcomes in these preclinical studies might function as a case study in the challenges of translating preclinical observations to clinical research. The utility of bexarotene for human AD can be resolved only by studying human AD. Studies of pharmacodynamics of the effects of bexarotene on ApoE in healthy controls will provide important biological information, but these effects might differ markedly from pharmacodynamics in AD where amyloid clearance, aggregation, and deposition are dramatically different from those in healthy volunteers. A notable advantage of repurposing drugs approved for other indications that exhibit pharmacodynamic features relative to the treatment of AD is the safety data available on these agents. Bexarotene has been used in the treatment of many elderly patients with cutaneous T cell lymphoma since its approval. Moreover, AD patients and their caregivers have shown a high tolerance for side effects if treatments have promise of ameliorating their disease (Bearer et al., 2007). Thorough monitoring of both known and unknown side effects is required for responsible human clinical trials, and many safety measures are built into the clinical trial being performed at the Cleveland Clinic Lou Ruvo Center for Brain Health. The clinical trial we are conducting will not solve the issue of whether bexarotene is a potential therapy for AD. It will not confirm or disprove any aspect of the amyloid hypothesis or the RXR pathway. It will resolve the issue of whether bexarotene given at a specific dose for a specific amount of time and measured with specific outcomes has measurable effects in patients with AD. This is the most information that any clinical trial can be expected to provide. A beneficial effect of bexarotene will be followed by further exploration of dose responses, the potential value of intermittent therapy to minimize toxicity, the testing of other agents with effects on RXR-related pathways, and optimization of a related molecule with a better adverse event profile. A negative outcome will be followed by a comprehensive review of dose and duration of therapy, optimal outcomes, and integration of emerging preclinical data. The clinical trial being implemented at the Cleveland Clinic Lou Ruvo Center for Brain Health is a logical next step for exploring this potential pathway of therapy for AD. The trial is given increased urgency by the failure to produce disease-modifying effects through other approaches.
Like many others, our group was excited about the findings published by Gary Landreth's group (see Cramer et al., 2013) and we repeated the main experiments with short-term dosing of bexarotene in the mutant APPSWE/PS1ΔE9 mouse model. While the ABCA1 target was upregulated in APP/PS1 mice treated with bexarotene, this drug failed to attenuate Aβ plaques or fear-conditioning deficits. In addition, we are unable to replicate a robust and persistent fear-conditioning deficit in APPSWE/PS1ΔE9 mice even with an alternate, highly sensitive testing paradigm. Instead, we found significant gender differences present in plaque load and the fear-conditioning task, both primary measures used by Cramer et al. Bexarotene has now been tested in several animal models of Aβ amyloidosis besides APPSWE/PS1ΔE9, including APP/PS1-21 and 5XFAD (Veeraraghavalu et al., 2013) and APPSWE/PS1ΔE9 with APOE3/4 allele knock-ins (Fitz et al., 2013). All have failed to replicate a change in soluble or plaque forms of Aβ in brain tissue, with the exception of a single positive finding from Verraraghavalu et al. that the non-pathogenic, soluble Aβ40 decreased after acute treatment with bexarotene in the 5XFAD mouse model, but not in the APPSWE/PS1ΔE9 or the APP/PS1-21 models. Fitz et al. reported a significant decrease in interstitial fluid Aβ levels, though this was not replicated in their ELISA analysis of brain tissue for soluble or insoluble Aβ. Together, the array of published work on the effect of bexarotene on pathology and cognitive impairment in mouse models of Aβ amyloidosis produces no rigorous evidence that bexarotene is a suitable candidate for the treatment of Alzheimer's disease.View all comments by Katherine LaClair


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Three children killed in a Louisiana house fire on Christmas morning were from Valley Head in DeKalb County, according to officials.
12-year-old Jasmine Mejia and two of her brothers, 11-year-old Josue Mejia and 9-year-old Rommy Mejia, perished when a fire broke out in the mobile home where they were staying in Houma, Louisiana, for the holiday.
The fire marshal said the fire started in a living room where the family was staying.
The home was completely destroyed. There's so much damage investigators said they may never be able to determine an exact cause of the fire, but they suspect a space heater may be to blame.
The home didn't have any smoke detectors that worked.
The children's parents and five other children were taken to a burn unit at a hospital in Baton Rouge.
Fire investigators said the children's father was burned rescuing one child after smoke came under his bedroom door.
News of the tragedy quickly spread back home to fellow students and teachers at Valley Head School, who said the children will be greatly missed.
"Very smart, very well-behaved. Everyone liked them. They ran all of your errands, very social; they were just very well-liked and loveable. Rommy, who was in my class, just hugged constantly... very sweet," recalled teacher Tara Kirby.
Kirby said she and the staff of the school of just 500 students said they will be bracing for a tough day when classes resume from the winter break.
"It's going to be heartbreaking when they walk in. And that's probably when it will hit; when his desk is empty and he's not there. But we have things planned. We have counselors from around the county that's going to come in and speak to the students," Kirby said.
She said she will talk to her students about grief and how to cope with loss. They will also celebrate the lives of the three children lost and remember everything the loved about them.
Kirby said a memorial fund has been set up at the three locations of Citizens Bank in Valley Head, Ider, and Mentone.
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Product ID: KUR1131-KUR1135
Our primary delivery methods are US Postal Service, FedEx and UPS. Orders ship based on their estimated production times, which are listed on the product's page. We will send you an email notification with tracking information once your order is shipped. Then you can go to the carrier's order tracking page to check on the status of your shipment.More Shipping Info
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Kurgo Quantum Dog Leash This product helps out in many different ways. It extends from a 6 foot long lead to a shoulder or a waist leash, to a double dog walker. All with a simple caribiner adjustment.
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The Florida primary is in 11 days and one of the races to watch is the fight for Florida's U.S. Senate seat.
Representative Connie Mack is among seven republicans vying for their party's nomination and the shot to go head-to-head in November with democratic incumbent Senator Bill Nelson. Instead of going after his republican challengers, Mack is already focusing his ads on Nelson.
One of them paints Senator Nelson as the state liberal who sides most of the time with the president and the Democratic Party. It's meant to appeal to the more conservative voter – but we wanted to know exactly how much of it is true?
This ad hit the air the week of the president's most recent campaign tour of Florida. It's paid for by Freedom Pac and supports Congressman Connie Mack.
The ad states, "Nelson voted for Obamacare."
We checked into Nelson's voting record - available to the public at Senate.gov - and found that, yes, in 2009 he did vote in favor of the Patient Protection and Affordable Care Act.
This claim is true.
The ad also states, "And chose to side with President Obama 98 percent of the time."
Freedom Pac is referring to Nelson's voting record since President Obama took office.
The senator's office debunked the claim saying, "He supports the president's proposals when he agrees with them and opposes them when he doesn't. The bottom line is: Nelson puts Florida first."
There are several websites dedicated to measuring how often a senator votes with their party and here's what we found:
A Washington Post analysis of the 111th Congress shows nelson voted with his party 93 percent of the time and for the 112th Congress 94 percent of the time.
A similar site that tracks Congressional roll call is Opencongress.org. It only measures the 112th Congress and it shows Nelson voted with his party 92 percent of the time. There are a few percentage points difference between what we found and what the ad claims. So we rank this claim - mostly true.
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The trial for a Lumberport man accused of sexually abusing two female children continued Thursday.
Judge J. Lewis Marks, Jr. heard closing arguments and the case went to a jury, comprised of eight men and four women, for deliberations around 2:25 p.m. Just before 5 p.m., the jury returned to ask Judge Marks a question regarding evidence in the case and continued deliberations. At 5:30 p.m., the jury announced that it had found Corriveau guilty on sexual abuse, incest and first degree sexual assault charges.
Judge Marks heard testimony Thursday from Michael Corriveau, who told the jury multiple times that he didn't perform the acts he is accused of committing. Corriveau took the stand for about 20 minutes.
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While Teen Mom-star-turned-porn-actress Farrah Abraham may be the most popular attraction at the Exxxotica convention this weekend in Fort Lauderdale, there's a new kid on the block of booths with hardcore DVDs, porn actress autographs, erectile help and S&M whips.
There's the booth of BeLoved, a new Miami Beach church that ministers to those who work in the sex business.
Manned by half a dozen Christians who promise not to judge, the booth adorned with its "Jesus loves porn stars" logo was seeing a steady flow of conventioneers during Friday's packed opening night.
"Look at how many people are at this convention," said pastor Timothy Savage, whose ex-stripper wife founded the ministry. "It's proof that western culture has fully embraced the medium of porn. It's not going anywhere.
"So, it makes sense to minister to it instead of fighting it."
Savage's faithful, up to 40, gather at 8 a.m. Sundays at the Miami Tattoo Co. parlor on Washington Avenue for prayer and nondenominational fellowship. Most work in strip bars and may stumble into his services straight from the job.
"Our message is that Jesus loves everybody, even porn stars and strippers and swingers. We're not encouraging anyone to quit what they're doing."
This, however, doesn't mean that Savage and his followers condone what goes on in porn, strip bars or massage parlors.
A former hip-hop DJ and frequent brothel visitor, Savage calls those who leave the sex industry "survivors."
"As in everything that's pleasurable, there are addictions involved," he said.
Riley gets served
Miami Heat boss Pat Riley was served a subpoena before Thursday's Heat-Indiana Pacers NBA playoff game at American Airlines Arena.
Heat staffers seem to have changed their attitude drastically after Gossip Extra's report that team representatives had blown off a process server with paperwork for an upcoming trial involving Heat guard Dwyane Wade.
"I guess the Heat read [The Herald's] story," said process server Chris Yeoman of Gotcha Legal Services. "We figured we'd try it again, and we went back to the arena.
"This time, their lawyer came out and was very nice and polite and accepted service for Riley. Everything suddenly became very easy."
Last week, the process server said, in-house lawyer Raquel Libman wouldn't accept. The subpoena is for Riley to testify in a mid-June trial to determine the division of marital assets between Wade and ex-wife Siohvaughn Funches.
House getting Trumped?
South Florida's most expensive single family house could meet a wrecking ball sometime soon.
Yep: The 33,000-square-foot Palm Beach waterfront digs that Doral Golf Resort & Spa owner Donald Trump sold in 2008 for a record $95 million is expected to be leveled by the end of the year.
"It's one of the plans we're considering," said the 6.8-acre property's manager, David Lifson.
The proud owner of the house, which has a ballroom, a full-sized art gallery and a 500-foot beach, is Russian oligarch Dmitry Rybolovlev. He's rumored to have stayed at the joint one time.
Said Trump of the property: "I don't care about the house. I bought it for $41 million, put in $3 worth of paint and gave it a good cleaning — and I sold it for the highest price ever."


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ABC News reports that the names were disclosed when Taliban spokesperson Qari Yousuf Ahmedi forgot to use the BCC function, and instead CC'ed the list, effectively making the addresses available to the public
The list is made up of mostly local and international journalists, but includes email addresses of academics, activists, and two that appear to belong to a provincial governor and an Afghan legislator, respectively.
Afghanistan-based journalist Mustafa Kazemi tweeted the following after the list was made public: "Taliban have included all 4 of my email addresses on the leaked distribution list. Quite reassuring to my safety."
Kazemi added that "On that Taliban email where they disclosed all 500 recipients' email addresses, there is a large number of Taliban personnel email also.
Ahmedi did not respond to ABC for comment.


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Gloucester Daily Times
---- — To the editor:
I would just like to take a brief moment to ask our current mayor one simple question, but before I do perhaps I should give a little insight as to why I, and many others who face the same problem, want an answer to this question.
My wife and I recently purchased a home in Magnolia, which we fell in love with from the moment we saw it. We love living here and, to be honest, there are few places I would rather be and I'm almost certain there is nowhere else my wife would want to be. We felt, and still feel, incredibly lucky to be in this position when so many others are barely making ends meet.
The one big downside about living in Magnolia, or any of the other outlying areas of the city for that matter, is the fact that the closest viable fire station to my own home is not even in Gloucester, it's in Manchester.
Which brings me back to my question: Mayor Kirk, can you please tell my family and the other families this impacts why stockpiling "free cash", an oxymoron if ever there was one, always seems to trump ensuring the safety of those living in these areas?
Is a small upgrade in our bond rating and the nominal savings that comes with that really more important than properly funding essential services vital to the safety of our community? Would it be, even if those savings were vast?
OK, so I lied — I guess that's really three questions. But I'm hoping they are all worth your time to consider and hopefully answer.
Western Avenue, Magnolia


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Updated Jan 25, 2013 - 6:37 pm
The early favorite for NHL Celebration of the Year
By Arizona Sports
Originally published: Jan 25, 2013 - 6:27 pm
Originally published: Jan 25, 2013 - 6:27 pm
Don't tell 19-year-old Nail Yakupov that it's only the first week of the NHL season.
The first overall pick in the 2012 draft has had quite a debut for the Edmonton Oilers. After scoring his first career goal Tuesday against the San Jose Sharks, Yakupov did one better two nights later against the defending Stanley Cup champions.
Down 1-0 with under 10 seconds to go, Yakupov took a rebound off a shot from Taylor Hall, and calmly put the puck past Los Angeles Kings goaltender Jonathan Quick to force overtime.
While the Oilers eventually won in the extra session, the night will most certainly be remembered for Yakupov's post-goal celebration. Eat your heart out Theo Fleury:
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D&W talk to all the top decision makers in Arizona sports.


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Satin fabric is smooth, shiny and silky on the outer side and dull on the reverse. Satin is made of 100% polyester fibers. It is a lightweight fabric. It is best for warm climates and times of year. Satin is polyester, but does have a luxurious feeling that is similar to silk. Our satin bath robes and pajamas for men are simple and elegant. They come in a variety of classic prints including paisley, fleur-di-lis and diamonds.
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March 10, 2003
COFFEE CO. - Follow the yellow brick road, and you find, not brick, not asphalt, but a dirt road turned to mud and rivers running through it by a weeks worth of heavy rains.
"We have to take mud out and put gravel in to get it to where busses can travel," Coffee County Road Director Don Stokes said.
At least nine roads were far from ready at sunrise Monday morning, marked by wash out and road closed signs. That's why the Coffee County School system made it a four day weekend.
"Still wet so asked Mr. Lee to close because one day would really help us dry it up and get around," Stokes said.
Some roads were difficult for even the repair crews to get down. Calls of vehicles stuck in the mud have been quite common the past few days. People living on washed out roads are asked to be patient, at least some motorists are listening.
"You can't tear up road overnight and can't put it back together overnight, road I live on tore up at both ends, it takes a while," Clark Holton said. He lives in the neighborhood.
"We had crews out, Saturday, and Sunday and we'll be out until dark tonight," Stokes said. On Tuesday morning school busses will be back on the roads, hoping to avoid the remaining mud and wet spots.
Coffee County has nearly 700 miles of dirt roads and less than 400 miles of paved roads. They are using local option sales tax money to pave about 10 miles per year.
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Everyone living with HIV has a story to tell. Find out how to share your own experiences in one or both of the series below, which feature the writings of readers like you.
Whether it was AZT or Atripla, the 1980s or the 2010s, a person living with HIV who is on treatment always remembers his or her first pill. And we want to hear about it! Were you hesitant to begin treatment? How did you find the regimen that was right for you? Write out your story (between 200 and 1,000 words, please!) or film a YouTube video, and email it to firstname.lastname@example.com. Read the user-submitted stories that are part of this series below!
|Triumeq (Tivicay + Epzicom) Becomes Newest Single-Pill HIV Treatment Regimen
|The Role of Triumeq in HIV Treatment
|12 Ways to Give HIV Stigma a Well-Deserved Side Eye
|How Does PrEP Affect Fertility and Pregnancy Outcomes?
|Insight Into HIV Transmission Risk When the Viral Load Is Undetectable and No Condom Is Used
|The Role of Triumeq in HIV Treatment
|12 Ways to Give HIV Stigma a Well-Deserved Side Eye
|Insight Into HIV Transmission Risk When the Viral Load Is Undetectable and No Condom Is Used
|Getting to the Bottom of It: Anal Sex, Rectal Fluid and HIV Transmission
|ACT UP Calls on Congress for Price Cut on Sovaldi for Hepatitis C Treatment
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It is a long way from Minnesota to South Georgia but Edward Tabut could probably run the entire trip.
Edward Tabut won the Albany Marathon Saturday morning.
The Coon Rapids, Minnesota resident completed the 26-mile course in 2:21:05.
Christopher Zablocki from Connecticut finished second 23 seconds behind Tabut.
Tabut says he just started running marathons last year and this is his 6th event.22-year old
Taylor Stephens from Savannah won the women's marathon with a time of 02:58.
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Creeks and Peaks features breathtaking full-colour photographs of some of the flowing waters, at the base of a number of grand peaks, in the Canadian Rocky Mountains.
Take a journey through these areas where you are led to some of the off beaten paths that follow the grandeur, flow, and light that exists in these special places.
Lawrence (Lars) Steinke illuminates these locations with the use of light and form through a camera lense. With this collection of photographs he hopes to show you places and features that are often not seen and more rarely photographed.


text:
40 pages | 8.5 x 11
The third edition of On Being a Scientist is now available here.
Since the first edition of On Being a Scientist was published in 1989, more than 200,000 copies have been distributed to graduate and undergraduate science students. Now this well-received booklet has been updated to incorporate the important developments in science ethics of the past 6 years and includes updated examples and material from the landmark volume Responsible Science (National Academy Press, 1992).
The revision reflects feedback from readers of the original version. In response to graduate students' requests, it offers several case studies in science ethics that pose provocative and realistic scenarios of ethical dilemmas and issues.
On Being a Scientist presents penetrating discussions of the social and historical context of science, the allocation of credit for discovery, the scientist's role in society, the issues revolving around publication, and many other aspects of scientific work. The booklet explores the inevitable conflicts that arise when the black and white areas of science meet the gray areas of human values and biases.
Written in a conversational style, this booklet will be of great interest to students entering scientific research, their instructors and mentors, and anyone interested in the role of scientific discovery in society.
Institute of Medicine, National Academy of Sciences, and National Academy of Engineering. On Being a Scientist: Responsible Conduct in Research, Second Edition. Washington, DC: The National Academies Press, 1995.
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Carteron proud of third place finish
Mali head coach Patrice Carteron said his side were proud to have achieved third place in the Africa Cup of Nations after a 3-1 win over Ghana
(01:15) | February 10, 2013
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Conte looking to lift Italy
International Football: Stewart Robson believes Conte is one of the best coaches in Europe but needs better players to score goals.
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Pope Francis visited by his football team
International Football: The Pope was visited by the Argentinean football team San Lorenzo in Vatican City after they won the Copa Libertadores.
(01:09) | Aug 20, 2014
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Conte lands dream job
International Football: Antonio Conte has spoken of his delight at being selected as the new head coach of Italy.
(01:24) | Aug 20, 2014
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Robson: Balotelli wrong fit for Liverpool
Premier League: ESPN FC's Stewart Robson explains why Mario Balotelli is a wrong fit for Brendan Rodgers and Liverpool.
(01:26) | Aug 21, 2014
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Dzeko: City is a second home to me
Premier League: Manchester City striker Edin Dzeko has signed a new four year deal with the Premier League Champions.
(00:53) | Aug 21, 2014
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Lochte glad to see Phelps back in action
More Sports Video: As he prepares to face Michael Phelps at the Pan Pacific Championships this week, Ryan Lochte says he's glad to see the 18-time Olympic champion back in action.
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Scott looking to end on high
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Stosur sails past Bouchard
Tennis Video: Sam Stosur powered into the quarter-finals of the Connecticut Open with a 6-2 6-2 win over Eugenie Bouchard.
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McEnroe: Murray needs to step up
Tennis Video: Four-time US Open champion John McEnroe believes Andy Murray needs to perform this year at Flushing Meadows, after a difficult season.
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Home > Post > Post 3 > Post 3 News Release > 2012 News Releases > News Release
News Release
Trooper Jonathan M. Biven
Public Affairs Officer
Kentucky State Police
Post 3, Bowling Green
(270) 782-2010
Click here to e-mail Trooper Jonathan M. Biven
Update to the Murder Arrest in Hart County
Date of News Release: 03/25/2012
(Bowling Green, KY) -- The victim of the stabbing complaint that Kentucky State Police Post 3 Bowling Green responded to on Saturday, March 24, 2012, has been identified as Patrick L. Dunlap (52) of Smithville, TN.
The investigation is still ongoing.
Original News Release Below:
Murder Arrest in Hart County
Date of News Release: 03/25/2012
(Bowling Green, KY) -- On Saturday, March 24, 2012 at 5:37 P.M. (CST), Kentucky State Police Post 3 Bowling Green responded to 380 Hatcher Valley Road in Horse Cave, Kentucky. The call was in regards to a male subject that had been allegedly stabbed at the above residence.
When KSP Troopers arrived on scene along with Hart County Sheriff's Deputies they found the male subject located inside the residence with apparent knife wounds to his body. There was also two other subjects located at the residence upon the arrival of law enforcement.
At 9:05 P.M. (CST), Kentucky State Police Detectives arrested Douglas W. Miller (41) of 380 Hatcher Valley Road in Horse Cave, Kentucky. Mr. Miller is charged with the murder of the male subject.
The other subject that was at the residence at the time of the murder has been identified as Deborah Thistlewaite (50) of Bloomfield, Kentucky. Ms. Thistlewaite was arrested by the Hart County Sheriff's Office on unrelated warrants.
Mr. Miller and Ms. Thistlewaite were both lodged in the Hart County Jail.
The male subject's body was taken to the Medical Examiner's Office in Louisville for autopsy. The male subject's name is being withheld pending notification of family.
Detective Michael May is leading the investigation. He was assisted by KSP Post 3 Personnel, Hart County Sheriff's Department, Hart County Coroner's Office, and members of the Horse Cave Fire Department.


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What kind of knot is that?
Darren, The cord is attached to the quick\link with a figure 8, clove hitch to equalize the system, tied that off with a trucker's hitch to keep the clove from slipping, and backed up with a mule knot (can't see in the photo, but the mule is attached to the webbing with a biner also).
Word is the nuts have been stripped off this anchor - so don't expect them if you are heading up.
Booty! (Lame)


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Students Gather To Remember Slain 14-Year-Old
Aaliyah Johnson, Her Father Reuben Johnson Both Found Dead In San Carlos Home Saturday
Hundreds turned out at West Hills High School in Santee on Sunday to remember a slain 14-year-old girl.
» Sign Up For Breaking News Alerts» Like Us On Facebook» Follow Us On TwitterAaliyah Johnson, 14, and her father Reuben Johnson, 56, were found dead on Saturday in their San Carlos home. The teenager's mother, Regina Johnson was arrested Saturday and is suspected of fatally shooting her husband and daughter possibly last Wednesday and then staying home with the bodies for three days.On Sunday, nearly 200 students and their families gathered to remember Aaliyah. They wrote messages on poster boards and released balloons with fond farewells.Family friend Anderson Hartfield told 10News, "I dont know how It's going to be tough getting over this one.""[Aaliyah] was really humble," said longtime friend Jenae Parlier-Ned. "I just can't believe this happened to her."Police said the girl's mother was booked into jail on two counts of first-degree murder. She is scheduled to be arraigned on Wednesday. She reportedly called a relative in Washington state, saying her husband and daughter were dead."I never would have guessed that anything would happen to her," said Tyffannie Covey, another friend of Aaliyah's.Covey, who said she had known Aaliyah since kindergarten, said she is shocked that the girl's mother will be charged with their deaths."Her mom used to be so sweet," added Covey. "We would always talk and then her dad always made me laugh. They were a really close family."Aaliyah's 14-year-old boyfriend, Michael Alfaro, laid flowers at the front of the school on Sunday. Alfaro told 10News that the couple last texted late Tuesday night about her wanting to learn Spanish.On Sunday, he tried to remain strong as he witnessed the presence of friends on the school's campus."I knew a lot of people were going to come here and support her because we all loved her," he said.Her friends gathered for a group photo near the school sign which was covered with purple balloons, stuffed animals and flowers.They had this final message for her: "We love you, Aaliyah!"


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Keystone Lake was quiet on Friday afternoon, but in 24 hours, that was expected to change.
All around the lakes, preparations were underway for the kick-off to the summer season. Marinas and restaurants, like Pier 51, were gearing up for the rush of visitors that Memorial Day weekend brings, every year.
"It gets pretty crazy. A lot of people," manager, Shane Pratt said, laughing. "Whole lot of people. That whole parking lot up there will be packed tonight -- guaranteed."
A packed house is what Pratt was hoping -- and preparing -- for.
"If the weather stays nice like this, we'll be busy today, all day Saturday, all day Sunday, and Monday," Pratt added.
Weather was at the front of everyone's mind, with fingers crossed that Mother Nature would keep outdoor activities dry.
"Hopefully, we won't get no rain. I can't believe you said that. Don't jinx us -- we need the sun. We've had enough rain," said visitors, Rick and Connie Patterson, when asked about plans, if rain moves in.
The Pattersons are no strangers to Keystone Lake. They are the kind of loyal customers that Pratt and everyone at Pier 51 want to see on these holiday weekends.
"Every memorial day weekend, we come here. We're here, Labor Day weekend, all through the summer, 4th of July," they said.
That loyalty is what Pratt said he is banking on, bringing on extra hands to help with the rush.
"I mean, it's just crazy-busy. Going to have a lot of -- lot of staff," Pratt said, laughing.
Visitors that Tulsa's Channel 8 spoke with said, rain or shine, their weekend plans will go on, as scheduled.
Evangelist Franklin Graham prayed on a sidewalk outside the Pentagon Thursday after his invitation to a prayer service inside was withdrawn because of comments that insulted people of other religions. More>>
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- Room Rates
Room rates are available on the the Student Accounts website
Lyons and Breen are two of the apartment buildings on campus. Living in either building is a natural step in the progression of student development. The apartments offer a variety of amenities such as full kitchens with stoves, microwaves, and full size refrigerators.
Each apartment is also complete with two full bathrooms. These juniors and seniors-only apartments offer all of the benefits of living off campus, but with a network of support that is only provided with on campus housing. It is indeed the best of both worlds.
Location: Northwest Campus
- Lyons: 32 (coed by apt.)
- Breen: 32 (coed by apt.)
Room Dimensions: Single 11' x 9'
Window Dimensions: Single 36'' x 48''


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Creating Wines of Distinction and Personality
Knights Bridge has enlisted the talents of rising star winemaker Jeff Ames. Using fruit from exceptional vineyards, he produces specific wines that reflect each vineyard's terroir and his own sense of style. This allows Knights Bridge to produce wines of great distinction and personality from our estate vineyards and other notable properties.
Jeff Ames
Having worked under some of the most respected names in winemaking, Jeff has established himself as a winemaker known for crafting wines of distinct style and finesse. Jeff served as assistant winemaker under Thomas Brown, James Johnson of Bisou, Barry Waitte of Tamber Bay, and also worked at Howell Mountain, Schrader Cellars and Maybach Cellars before becoming winemaker for Kenward Family Wines. There, he made wine from fruit purchased from such top vineyards as Howell Mountain, To Kalon, Hudson Vineyard, and Judge Vineyard. Besides making wine for Knights Bridge, Jeff is the owner and winemaker of Ames Wine Company, founded in 2005.


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Lehotak will be a part of the Powerade NCAA Youth Clinic, a community outreach program that connects kids ages 8-16 with the basketball, baseball and softball championships. Participants receive instruction from NCAA coaches and student-athletes on fitness, healthy lifestyles and sportsmanship. The clinics also feature a session for parents and guardians with information on recruiting, academic and eligibility issues.
Joining Lehotak for the clinic will be senior Katie Kelly and junior Sarah Sigrest, who each plan to coach following their careers with the Dolphins.
"I'm honored to be chosen for this event," said Lehotak. "I love teaching softball and excited that I get to represent our school at this event. This is a once in a lifetime opportunity so I'm glad we get a chance to do it."
Lehotak is coming off of her strongest year at JU after leading the Dolphins to the A-Sun regular season and tournament titles in 2011 to earn A-Sun "Coach of the Year" honors. JU won 26 of its final 30 games en route to a school record 44 victories. The Dolphins also posted a program best 22 home wins, including 16 in a row (the fourth-highest nationally).
Kelly, who didn't miss a game in her four years, finished as JU career leader in hits (207), runs (111), doubles (38), RBI (103), at bats (674), total bases (277) and assists (357). She also hit a career-best .426 in A-Sun play this season to earn second team all-conference accolades.
Sigrest was named A-Sun "Pitcher of the Year" after posting single-season records in wins (27), strikeouts (208), ERA (1.10) and shutouts (10). She posted a 12-0 mark with an 0.56 ERA in her final 13 appearances before the NCAA Tournament to receive Louisville Slugger/NFCA second team all-region honors.


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Spend $250 on Currey & Company, get $25 in store promo code.Promotion code can be redeemed on your next Zinc Door order. Enter code CURREY25 on the shopping card page.


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ATHENS, Ga. (AP) - Brandon Boykin had two long interception returns and Tavarres King caught a winning touchdown pass Wednesday in No. 19 Georgia's scrimmage win against a Bulldogs scout team running Boise State's playbook.
Richt used a scenario that had Georgia down 31-0 to Boise State to begin the second half. The Bulldogs "won" 34-30 behind a combined 115 yards rushing by tailbacks Isaiah Crowell and Ken Malcome and six interceptions by the Georgia defense.
While the real Bulldogs managed to beat the fake Broncos, coach Mark Richt says there's much room for improvement before they face the real Boise State September 3rd in Atlanta.
Richt said his team would not have been ready if the game were played Wednesday, citing an opening drive that made the offense appear sloppy and unprepared.
He said while it wasn't awful, the play wasn't clean. He also identified communication and substitution patterns as potential concerns.
Richt named four seniors - Boykin, center Ben Jones, defensive end DeAngelo Tyson and kicker Blair Walsh - as captains for the Sept. 3 opener in Atlanta.
Crowell gained 54 yards and scored once despite just six carries, but still hasn't done enough to earn a starting nod in Week 1. Richt said he still has Richard Samuel atop his pecking order ahead of the talented freshman, though Samuel continues to miss time with a quad injury.
Copyright 2011 by The Associated Press. All Rights Reserved.
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Expired Property Listing
This property is disabled.
Carib Condos in Jamaica
- bedrooms 1
- baths 2
- sleeps 3
- pool no
- hot tub no
- pets allowed no
- type Condo
- community
rates (USD)
/ night
$ 700 - $ 700 / week
vacation rental description
412 Carib Condo is a two floor, one bedroom apartment (approx. 1, 200 sq.ft). The bedroom and main bathroom is on the second floor. Kitchen, living room and second bathroom is on the first floor.
The first floor varanda is immediately over the ocean. The lapping of the waves eases you to sleep at nights. You're well tucked away from the hustle-bustle of the main road, but within ten minutes walk of the main town of Ocho Rios. There is a beach area within three minutes walk of your doorsteps.
The compound is an idelic setting of singing birds, green plants, bright flowers and the ocean.
condo rental amenities
There's a refregerator, microwave, Cable TV and more...


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A collection of scholarly works about individual liberty and free markets. A project of Liberty Fund, Inc.
Theory and History: An Interpretation of Social and Economic Evolution, ed. Bettina Bien Greaves (Indianapolis: Liberty Fund, 2005). http://oll.libertyfund.org/titles/1464,
|Available in the following formats:
|LF Printer PDF
|This text-based PDF was prepared by the typesetters of the LF book.
|EBook PDF
|This text-based PDF or EBook was created from the HTML version of this book and is part of the Portable Library of Liberty.
|This version has been converted from the original text. Every effort has been taken to translate the unique features of the printed book into the HTML medium.
Liberty Fund's edition of this work. Theory and History is primarily a critique of Karl Marx, his materialism, and his prediction of the inevitability of socialism. This book discusses the theory of economics, i.e., the study of purposive human action, and with history, the record of the past actions of individuals. History looks backward into the past, but the lesson it teaches concerns things to come. It opens the mind to an understanding of human nature, increases wisdom, and distinguishes civilized man from the barbarian.
The copyright to this edition, in both print and electronic forms, is held by Liberty Fund, Inc.
This material is put online to further the educational goals of Liberty Fund, Inc. Unless otherwise stated in the Copyright Information section above, this material may be used freely for educational and academic purposes. It may not be used in any way for profit.


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Largent80 wrote:
Largent80 wrote:
vongstaTHEmonsta wrote:http://forums.49ers.com/showthread.php?t=136825&page=4
There's is pretty good of our seahawks.
HawkFan72 wrote:
cccrew wrote:
Are you seriously implying that after a decade of suck that I should feel bad about losing in the NFC Championship game to the eventual Super Bowl Champion? With a rookie head coach? And no offseason program due to the lockout? And no Wide receivers? In overtime by 3 points? Really?
Wow. LOL. Try again.
Bakergirl wrote:Alex Smith
Aaron Rodgers
A merging of the two...
= Freakin scary.
Largent80 wrote:
Return to [ THE OFFICIAL NET NATION FAN FORUM ]


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Vt. neighbors say man in NH hotel stabbing had temperBy LISA RATHKE
The Associated Press | January 31,2013AP Photo
An undated photo provided by the White Mountain School in Bethlehem, N.H., shows Catherine Houghton, who was a trustee of the school.WEST DANVILLE Some residents of the small hometown of a man charged with stabbing a 70-year-old woman to death at a New Hampshire hotel said Wednesday the suspect was known for having a short fuse.
Prosecutors say 37-year-old Rodney Hill, of West Danville, repeatedly stabbed the woman Monday night in the lobby of the Hampton Inn in Littleton in what officials call a random attack.
Catherine Houghton, of Novato, Calif., died at a hospital shortly after the attack. She was a 1960 graduate of the White Mountain School in nearby Bethlehem and a member of the schools board of trustees. School officials said she was in town for board meetings Sunday and Monday and remained an extra day to rehearse with the schools a cappella choir.
What motivated the attack on Houghton is unknown. Prosecutors say Hill and Houghton were strangers who happened to be registered at the same hotel Monday night.
Jeff Downs, owner of Joes Pond Country Store, said Wednesday that Hill was a frequent customer of the store and its small cafe counter and that it didnt take much to set him off.
Downs said Hill was in early Sunday the day before Houghton was killed and was making such a ruckus that Downs came downstairs from his office to see what was going on. He said waitress Evelyn Daly told him, Oh, its just Rodney going off.
But Downs said that same waitress was so distraught Wednesday that she had to go home. Downs said she told him before leaving, It could have happened to any of us.
Downs said Hill was often very loud and opinionated but he never felt threatened by him. But Downs also said he was always happy to see him leave.
Katharine Pastula, who also works at the country store, said Hill could get riled up but she was never frightened by him. Hill did welding and other maintenance work on her familys farm, and they were shocked to learn of the charges against him, she said.
Hill graduated from Danville High School in 1993 and lives with his wife, Amy, and three children. Amy Hill has not returned a message seeking comment. The driveway at the familys home is posted with a No Trespassing sign.
Hill was arraigned on two second-degree murder charges Tuesday and is being held without bond. He is due back in court Tuesday for an evidentiary hearing.
Public defender Martha Hornick, who represented Hill during his brief court appearance, didnt immediately return calls seeking comment.
Senior Assistant Attorney General Susan Morrell said Wednesday that Houghtons autopsy has been completed but results wouldnt be released until today.
Houghtons is the first killing since 1999 in Littleton a community of 4,000 just west of the White Mountains National Forest in northwest New Hampshire, near the Vermont border.
Houghton held masters and doctoral degrees from Stanford University, had served in the Peace Corps in Nepal and worked as an international officer for Bank of America before joining the global business arm of the Commerce Department often working under the auspices of the U.S. Foreign Service at embassies worldwide.
Every indication Ive been given is, frankly, that this is a random, senseless attack, said Timothy Breen, head of the White Mountain School.MORE IN Vermont NewsMONTPELIER A lawsuit filed Wednesday against the state Department for Children and Families... Full Story
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Mon, 09/9/2013 - 11:37am
The STAAR Testing Schedule for the 2013-2014 has been finalized and is posted on the Quick Links at the bottom of the webpage. Please mark these dates on your calendar to try and avoid conflicts with doctor's appointments or out of town trips. The STAAR test is timed, so students will have to be in their testing rooms promptly at 8:30 on the days of the tests. Due to limit in staff on these days, please plan for your student to stay the entire day. Thank you!"


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WILLIAMSBURG, Virginia –Sophomore Sam Scolarici scored at the 103:39 mark to lead fifth-seeded Hofstra to a 2-1 double-overtime victory over third-seeded UNCW in the championship game of the 2012 CAA Women's Soccer Championship Sunday at Albert-Daly Field on the campus of William & Mary.
The Pride improved to 11-8-2 overall as they won the league title for the third time in school history (2005 & 2007). Hofstra also receives the league's automatic berth to the NCAA Tournament. Making their first championship game appearance since winning the CAA title in 2009, the Seahawks finished their season with a 12-7-3 record.
After both teams were unable to register a shot during the first overtime session, Scolarici teamed up with sophomore Lulu Echeverry just under four minutes into the second overtime session to score the game-winning tally. Echeverry gained possession in the Seahawks half and worked her way up the middle of the field before finding a streaking Scolarici at the top of the box. Scolarici was able to create separation from the UNCW defenders on the right side before sending a shot from 12 yards out into the lower-left hand corner of the net for her 10th goal of the season.
Earlier in the contest, Echeverry put the Pride up 1-0 in the seventh minute, tapping home a cross from freshman Leah Galton for her eighth goal of the season.
The Seahawks created several scoring opportunities after the Echeverry strike before finally drawing even at the 37:22 mark of the first half. Senior Stephanie Rose converted a penalty kick opportunity after sophomore Stephanie Bronson was taken down inside the box. The goal was Rose's league-leading 14th tally of the season.
UNCW nearly took the lead moments after the Rose strike as freshman Maddie McCormick teamed up with Rose on a give-and-go opportunity to create space before the McCormick sent a shot that beat Morphitis to the right side, but slid past the outside of the post.
Seahawk senior Kim Currie had the first opportunity of the second half, getting behind the Pride defense on the left side in the 52nd minute before sending a shot towards the lower right-hand corner of the net that Morphitis was able to get her left foot on to keep the game level.
McCormick almost found the back of the net in the 57th minute, sending a volley from the right side of the box that hit the top of the crossbar before continuing out of play.
Freshman Jeannine Molleda had the best opportunity of the second half for the Pride, battling her way through two UNCW defenders in the 72nd minute before firing a shot from six yards out that went to the outside of the right post.
McCormick had a pair of scoring opportunities in the final 11 minutes of regulation. In the 79th minute, McCormick unleashed a shot from the right side that Morphitis was able to keep out of the net. Less than three minutes later, McCormick was able to get to a loose ball at the top of the box and knock it past an oncoming Morphitis, but the Pride defense was able to clear the ball away before it crossed the goal line.
Hofstra posted a 20-19 shot advantage in the contest and enjoyed a 4-2 edge in corner kicks taken. Morphitis and UNCW senior keeper Caitlin Hunter finished the game with six saves apiece.
2012 CAA Women's Soccer Championship All-Tournament Team Eva Badana, Drexel Brooke Bendernagel, Hofstra Melissa Chapman, Drexel Leah Galton, Hofstra Kiersten Harpe, William & Mary Caitlin Hunter, UNCW Leci Irvin, William & Mary Jen Ludemann, UNCW Maddie McCormick, UNCW Emily Morphitis, Hofstra Jill Mulholland, Hofstra
Most Outstanding Performer: Emily Morphitis, Hofstra
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As more information surfaces, the severe mismanagement and "lack of integrity" within the Department of Veterans Affairs (VA) health system has grown increasingly clear. A nationwide audit of access and wait times at 731 VA facilities was released just days ago. The results were highly alarming and only added to my serious concerns about veterans' access to medical care. The audit found that more than 57,000 veterans have waited at least 90 days for their first appointment at a VA facility.
By Congressman Robert Hurt
I never see Rick Howell's Liberal Agenda before I write my column, so anything that looks like coordination between the two is not due to deliberate planning. Sometimes it's due to two political minds running in the same gutter. In other cases, it's pure coincidence. Last week's Bedford Bulletin witnessed one of those coincidences.
The Virginia Republican Party nominated Ed Gillespie on Saturday to run against incumbent Democrat Mark Warner for the U.S. Senate.
Gillespie easily dispatched two lesser rivals, and was nominated on the first ballot. Newspapers reported that even though some 4,200 delegates had registered, less than 3,000 of that showed up and voted.
In lockstep with regulatory expansion in nearly every part of our economy, on June 2nd the Environmental Protection Agency (EPA) put forth yet another rule, this time attacking affordable and reliable energy. Once again, we see the Executive Branch bypassing Congress to enact far-reaching legislative policies that would hit families, small businesses, and manufacturers in the pocketbook.
Last week, we commemorated the 70th Anniversary of the largest seaborne invasion in our history, which took place on D-Day. In honor of the anniversary of this fateful day, I participated in the National D-Day Memorial Commemoration in Bedford to commemorate the Anniversary of the Allied invasion of occupied France.
They were farmers, baseball players, factory workers.
They had girlfriends—they enjoyed using the dollar they earned at National Guard meetings to buy popcorn and share a drink at the movies.
The got Bibles for Christmas; they shot pool.
And they gave their all for their country.
Friday marks the 70th anniversary of D-Day, when this nation's best stormed the beaches of Normandy. And in the first wave were the best and brightest of Bedford.
Facts are indeed stubborn things, as Rick Howell wrote in the Liberal Agenda last week. Liberals are also stubborn things although I often tend to think of them as more perverse than stubborn.
One area where their perversity comes to fore is how they view the Constitution. When it suits them, they view the Constitution as a rubber document that can be stretched in any direction they choose. At the same time they can be hard-nosed strict constructionists when something can be used to support their social agenda.
Copyright © 2014
The Bedford Bulletin is your source for local news, sports, events, and information in Bedford County and Bedford, VA and the surrounding area.


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Team New York reaches half-way point by Team New York - over 3 years ago
"Team New York walks in Washington D.C. to support Breast Cancer research. The event raised over 5 Million dollars. The event took place in Washington D.C. on April 30th and May 1st, a two day walking event that started at the Washington Monument and ended 26 miles later in Chevy Chase, Maryland. We wanted to represent our home state NY while in D.C. Custom Ink helped to create this design and they came out beautifully. We we're proud to wear them and proud to walk and experience all that we did. Thank you Custom Ink for being a part of the Avon Walk for Breast Cancer."


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Pictured above, from left to right: Sarah Gray (3L), Kimberlee Martin (2L), Cristina Neuman (2L), Ligianette Cordova (3L), and Daphne Bareket (3L). Standing, Professor Ila Klion.
FIU Law's Board of Advocates Intercultural Human Rights Moot Court team competed at the Susan J. Ferrell Moot Court Competition on Saturday, Jan. 28, 2012. The competition was held at St. Thomas University School of Law in Miami Gardens.
The FIU team, which included five students, Gigi Cordova (3L), Daphne Bareket (3L), Sarah Gray (3L), Kimberlee Martin (2L), and Cristina Neuman (2L) won the Runner-Up trophy. In addition, Kimberlee Martin won the Best Orator trophy. The team also finished with the Second Runner-Up Brief/Memorial award.