text:
Funding opportunities
Derivation of new human pluripotent stem cells using small molecules
Funding Type:
New Cell Lines
Grant Number:
Funds requested:
$1 324 404
Funding Recommendations:
Not recommended
Grant approved:
Public Abstract:
Pluripotent stem cells have the potential to treat a variety of human diseases, including diabetes, cardiovascular diseases, Parkinson's diseases and Alzheimer's diseases, in cell replacement therapies. Human embryos are the main sources for producing human pluripotent stem cells that are genetically unmodified so far. Alternative methods for producing pluripotent stem cells include somatic cell nuclear transfer or therapeutic cloning, which needs unfertilized or newly fertilized eggs, and has been experiencing both ethical and technical difficulties. Recent progress in reprogramming by retroviral transduction of a cocktail of four transcription factors offers a solution to these problems because no embryos or eggs are needed in this system. However, the use of retroviral transduction represents a serious hurdle to the use of these induced pluripotent stem cells for therapeutic application, because retroviral transduction can cause activation of cancer-inducing genes and are therefore risky. The goal of this research is to create new pluripotent stem cells that are genetically unmodified by inducing endogenous pluripotency regulators using small molecules. Screening for small molecules that induce endogenous pluripotency factors to replace retroviral delivery of reprogramming factors will allow safer production of customized patient-specific stem cells from patient's own somatic cells and open up new avenues into stem cell therapies. It will make the dream of stem cell-based therapies come true in the foreseeable future.
Statement of Benefit to California:
The establishment of pluripotent stem cell lines opened a new era in biomedical research. Human pluripotent stem cells provide great hope to be used in cell replacement therapy for a variety of human diseases. The derivation and propagation of new lines of human pluripotent stem cells from somatic sources using small molecules will allow production of patient- and disease- specific stem cells in a safe and efficient manner. These virus-free pluripotent stem cells will have important research and clinical application for understanding, diagonosing and treating serious injury and diseases that Californians may suffer. Californians will therefore benefit tremendously from the outcome of the proposed research. In addition, the development of new methods to derive genetically unmodified human pluripotent stem cells that do not require the use of either human embryos or eggs will reduce the ethical concerns of Californians for stem cell research and will stimulate other stem cell-related research in California. This research will undoubtedly bring enormous benefits for California.
Review Summary:
Executive Summary The applicant proposes to develop new pluripotent cell lines using high throughput screening of a small molecule library to identify compounds that induce reprogramming in human fibroblasts. S/he will employ a reporter assay to screen for the transcriptional activation of two pluripotency regulators believed to be central to embryonic stem cell (ESC) identity, and then will determine if the identified compounds can be used to generate induced pluripotent stem cells (iPSC). The proposed work could lead to the identification of molecules useful for deriving new pluripotent cell lines from somatic cells without the need for retrovirus-mediated gene transfer, an important and significant goal. The approach constitutes a high-risk screening experiment, but it is likely, given the applicant's expertise and environment, s/he will be able to perform this screen. Reviewers praised the reporter construct design but differed in their assessment of the overall technical approach. One reviewer felt that the design of the screen is viable from a technical point of view, but another reviewer raised several questions with regard to feasibility. The applicant may identify molecules that are potentially useful, but in order to sort out hits from the high throughput screening campaign, and to identify those compounds that are worthy of further characterization, the expertise of a medicinal chemist will be necessary. However, an appropriate collaborator is not included in this proposal. Furthermore, the applicant prefers to identify a compound that activates both targeted genes but does not consider that such a compound may non-selectively activate a large number of genes through a broad and general mechanism. Thus, s/he needs to develop a secondary assay to rule this out. In general, follow-up assays that verify the purported activities of the compounds identified in the screen were inadequately described. In addition to these technical concerns, reviewers questioned whether the biology of reprogramming was adequately considered in the proposed screening approach. Dedifferentiation seems to be a sequential process with multiple steps involved, and reactivation of the two targeted genes is clearly a secondary event in this process. Thus, molecules that directly regulate the two genes can help to enhance or speed up the reprogramming process but will not be the ones that truly reprogram. Furthermore, it is possible that combinations of molecules that target multiple pathways and that individually produce a weak effect are required for reprogramming, and if so, the screen as proposed may not yield any active molecules. Reviewer Synopsis The goal of this proposal is to identify small molecules that can activate the endogenous Oct4 and Nanog locus in human cells. Proposed is a screen based on a dual luciferase high-throughput reporter, then to test if the identified compounds can be used to produce iPS cells and finally to show that these new iPS cells are truly pluripotent using standard pluripotency tests. City of Hope has obtained a chemical library of 70,000 compounds and the applicant is confident that there will be components that can directly reactivate two key pluripotency genes. Reviewer One Comments Significance: Dr. Yanhong Shi proposes to develop a new pluripotent cell line using high throughput screening and a reporter assay to identify compounds that induce reprogramming in human fibroblasts. The significance is that this work could lead to the identification of molecules useful for deriving new pluripotent cell lines from somatic cells without need for virus transfection. Feasibility: The proposal asks for support for 10% of the PI (no salary, however), four co-PIs (no salary), and three postdocs for 100% effort and salary. Aim 1 is to identify small molecules that activate endogenous human ES cell pluripotency regulators Oct4 and Nanog, two transcription factors believed to be central to stem cell identity. They will use an Oct4 and Nanog promoter-driven luciferase reporter gene system. Aim 2 involves the use of molecules identified from Aim 1 for secondary assays to confirm that they promote human embryonic stem cell morphology. Aim 3 is further characterization of the derived lines including gene expression and epigenetic profiles and pluripotency potential. My major criticism is that the assumption is that compounds identified through the high throughput screen are going to be adequate for use for purposes of somatic cell reprogramming. There may be molecules that are potentially useful but they will have a number of compounds they will need to sort through to determine which are worthy of further characterization. None of the people on this proposal have a medicinal chemistry background and this is absolutely necessary to help sort out hits from the high throughput screening campaign. The cell line for the high throughput screen has not been constructed yet, and this will take three months at the minimum, if all goes smoothly. The dual luciferase construct is a good design so that they can distinguish between compounds that increase expression of either gene or both in the same cells. They need to try to choose a cell line that expresses both to a similar degree so that the same conditions can be used for both signals. A stable cell line will be much preferred, although they mention the need for transients if expression levels are too low. This strategy really should be a last resort. They prefer a compound that activates both genes but need to be careful because these compounds may non-selectively activate a large number of genes through a broad and general mechanism. They need to develop the secondary assay to rule this out. They are choosing a human fibroblast cell line that has been shown previously to successfully produce pluripotent cells. They have a 70,000 compound library that has been used productively for other screens. They mention a million compound library of natural products through a collaboration with Strathclyde Institute for Drug Research that they could use if no hits are found. Another potential weakness is that if more than one target or pathway has to be modulated to produce the reprogramming, they will not be able to identify any active molecules. Combinations of molecules that produce a weak effect are a possibility and identification of the mechanism of how the molecules may be working will be important for interpretation of the effects. They propose to use microarray data to help determine mechanism and whether any deleterious effects such as oncogenesis are noted. The PI has experience with these types of assays and high throughput screening, the co-PIs have complementary skills that will be necessary for the project. They would benefit from a medicinal chemistry consultant to help sort out the molecules they identify in the screen. Responsiveness to RFA: The proposed work fits well in the RFA for development of new stem cells using an alternative method than from embryos from IVF. The proposed work will also potentially contribute to our knowledge about reprogramming. Reviewer Two Comments Significance: This Proposal addresses a significant problem in the field, since current technologies use integrating retroviral vectors for gene delivery. Feasibility: - design is clearly feasible from a technical point of view, it is likely that given the PI's expertise and the given environment they will be able to do this screen - problem with the biology: dedifferentiation seems to be a sequential process with multiple steps involved, reactivation of Oct4 and Nanog are clearly secondary events thus molecules that directly regulate Oct4 or Nanog can help to enhance or speed up the process but will be not the one that truly reprogram - overall high-risk screening experiment


text: 1 MICROSOFT Forza Motorsport 5 - for Xbox One Age minimum 3+ Racing Home delivery Collect in store £39.98 Product details Jump behind the wheel of some of the world's greatest cars in Microsoft's Forza Motorsport 5 exclusively for the Xbox One. Interactive racingReturning for the latest addition to one of the highest rated racing franchises in recent years, Forza Motorsport 5 is a high octane turbo-charged racing spectacular with stunning graphics and intelligent technology. Harnessing the power of the cloud, Forza 5 lets you pit your skills against adaptive AI as you find the perfect line around some of the... Find out more More info

subset: commoncrawl


text:
marked the kick-off of the new Health Insurance Marketplace Education Effort- a
new website to help Americas
sign up for health insurance.
called healthcare.gov, and it's the newest way to choose the plan that's best
for you.
and Human Services Secretary Kathleen Sebelius joined FOX29's Karen Hepp and
Sheinelle Jones live on "Good Day Philadelphia" Monday to talk about that, and
give the lastest on little Sarah Murnaghan.
Join FOX 29's Mike Jerrick and the Good Day Philadelphia team for a tasty night of yummy treats benefiting local youth.
WJBK-TV | Fox 2 16550 West Nine Mile Rd.Southfield, MI 48075Main Station: (248) 557-2000Newsroom: (248) 552-5103


text:
Charity fair for Great Ormond Street (From Borehamwood Times)
Get involved: send your pictures, video & news by texting BOREHAMWOOD to 80360, or upload here
Annbel Karmel to attend charity fair at Village Hotel, Elstree, for Great Ormond Street
5:10pm Thursday 8th November 2012 in News
Celebrity chef Annabel Karmel will be visiting a charity fair in Borehamwood to help raise cash for Great Ormond Street.
The baby and toddler fair, at the Village Hotel, in Elstree Way, will feature raffle prizes in aid of the children's hospital.
Mrs Karmel will be on hand to dish out some healthy cooking tips for children, and organizers will be canvassing the hall in an attempt to raise cash for the charity. The £5.50 entrance fee will also be donated to the hospital.
Anyone is invited to attend the event on Sunday, November 11 from 10am to 4pm.
Comments are closed on this article.


text:
Wednesday night in San Francisco, the Giants were no-hit by the Diamondbacks' Trevor Cahill through six innings. They did break through in the seventh, scoring a couple of runs, but by then the game was pretty much out of hand; Arizona led 6-2 going into the eighth inning.
In the top of the eighth, D'backs shortstop John McDonald led off with a single and was singled to second by Ryan Wheeler. The next hitter, rookie Adam Eaton, hit a ground ball to first baseman Brandon Belt, who threw to Pablo Sandoval at third in an attempt to get McDonald. That's when this happened:
Sandoval tagged McDonald; McDonald took exception, apparently, to how hard Sandoval tagged him. Sandoval took exception, apparently, to McDonald elbowing him in the chest after the tag. The two exchanged words; third-base umpire Greg Gibson held Sandoval back (no easy feat, as you might imagine), so there was no real fight, just a lot of cream-clad Giants and rust-colored Diamondbacks milling around third base until order was restored.
The D'backs eventually won the game 6-2 and crept to within 6½ games of the second wild-card spot; despite the loss, the Giants maintained their 4½-game lead in the NL West when the Dodgers lost to the Padres.
For more on the D'backs, please visit AZ Snakepit; for more on the Giants, please visit McCovey Chronicles.


text:
Discover Adionomy, Your Online Radio Advertising Campaign, Fast, Easy and Custom-Made!
Sycronomica is a melodic black metal band hailing from Munich, Germany. Formed in 1996, they released the Demo "Durch das Geaest" the same year. In 2000 they released a Live Demo, followed by a Promo Demo in 2002. In 2004 they finally released their first Full-Length album "Paths". In fall 2006, their latest album "Gate" has been released. Their lyrical themes are Feelings and Fantasy Tales. Sycronomica.de
No radio station found
No radio station found


text:
Friday, December 7, 2012
© Copyright 2014 Gwinnett Daily Post
DULUTH -- Rise up, Gwinnett. Atlanta Falcon's Thomas DeCoud is coming to town.
The dirty bird's safety is hosting a fan event Tuesday at the new Studio Movie Grill in Duluth for several lucky fanatics. DeCoud is choosing his favorite movie to watch with the crowd, plus food from the theater's menu.
But you must enter to win.
Fans can win passes through a random drawing by entering their name, date of birth and describe how they "rise up" to firstname.lastname@example.com. Entries must be received by Monday at 10 a.m.
Another way to win a pass is by attending the SMG's weekly Game Day series on Sunday, which will broadcast the Falcons/Panthers game. More random people will be selected during the game to attend.
DeCoud's event begins at 7:30 p.m. Tuesday. All winners and guests must be 17 years and older.
More like this story
- Safety DeCoud sets pace for Falcons with 6 INTs ( December 18, 2012 )
- DeCoud to sign new deal with Falcons ( March 6, 2012 )
- Falcons face tough road stretch ( October 19, 2009 )
- Safeties DeCoud, Moore added to Pro Bowl roster ( January 21, 2013 )
- Home sweet Dome
Falcons win another one at home, but face brutal road trip ( October 20, 2009 )


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text:
From the 2009 Youth Risk Behavior Surveillance System:
During the past 12 months, how many times did you use an indoor tanning device such as a sunlamp, sunbed, or tanning booth? (Do not include getting a spray-on tan.)
Data include adolescents who have used an indoor tanning device one or more times in the past 12 months.


text:
FILE - In this Dec. 8, 2011 file photo, White House Chief of Staff William Daley, left, and White House Press Secretary Jay Carney, second from left, listen during President Barack Obama's news conference in the White House briefing room in Washington. Administration officials say Daley resigning as White House chief of staff. (AP Photo/Carolyn Kaster, File)
WASHINGTON (AP) — William Daley is resigning as President Barack Obama's chief of staff just one year into the one of the most pivotal jobs in politics, senior administration officials said Monday.
Daley's job as day-to-day manager of the White House operation had already been changing — if not diminishing — as senior Obama aide Pete Rouse took over more of those duties in November. Yet Daley was not expected to leave the job and return to Chicago, where his family has long held a political dynasty, until after the November presidential election.
Officials confirmed the news on condition of anonymity because the president had not yet announced it. The president planned to do so later Monday afternoon.
Obama will now have the third chief of his staff of his presidency in the midst of a re-election year.
Daley is to be replaced by Jacob Lew, now the White House budget director. The change will be effective at the end of the month.
Obama chose Daley to be his White House chief of staff in January 2011, but the former banker and veteran political fighter Daley has had a somewhat rocky tenure.
In the least, the job has not seemed like the best fit.
Daley had been brought in to improve relations with the business community, Republican lawmakers and others with whom he had built ties over the years. He replaced Rahm Emanuel, who is now Chicago's mayor.
Daley served as commerce secretary under President Bill Clinton and ran Al Gore's 2000 presidential campaign. He's the brother of recently retired Chicago Mayor Richard M. Daley and the youngest son of legendary Chicago Mayor Richard J. Daley.
Daley's resignation was first reported by the Chicago Tribune/Los Angeles Times.
Associated Press
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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You're In. What's Next?
Being admitted to Western is the first step toward making your mark on the world as a part of the Western community. Congratulations! We've put together the list below to help you through your next steps to Western.
1. Finalize Your Decision
When you are ready to finalize your decision, you can easily accept or decline your offer of admission.
- Accept your offer today and pay the non-refundable $250 Enrollment Confirmation Fee. Your confirmation isn't complete without it. We encourage you to submit your enrollment confirmation as soon as possible to receive information about course registration, orientation programs, and to activate your Universal Account and Western email address.
- Online: once you receive your admissions packet in the mail you can confirm and pay using our online payment system
- Mail: you can mail your check payment and the Enrollment Confirmation form you received in your admit packet (print a blank form)
Can't afford the $250 confirmation fee at this time? Don't worry. The fee can be postponed until your first tuition bill if you've demonstrated significant financial need on your FAFSA. To request to have your fee postponed, email firstname.lastname@example.com with an explanation of your circumstances, along with your name and Western ID number.
- Decline your offer online. If you do not intend to come to Western, please withdraw your offer so your enrollment space can be given to another student.
2. Get to Know Us Better
- Facebook: Join the You're In! WWU New Students 2014 Facebook group and with your friends!
- Visit campus: Western's ideal location and gorgeous campus is one of the biggest reasons students choose to attend Western, so come see for yourself! We offer a variety of ways to visit, including daily tours, information sessions, and Western Preview, our admitted fall freshmen open house on April 5, 2014. Directions to campus, hotel suggestions and information about Bellingham are on the website as well.
- First Year Interest Groups (FIGs) offer freshmen a unique learning community their first quarter on campus. A group of 25 students enroll in three classes together – two larger general education courses and one small seminar. By connecting students with professors and campus resources, FIGs helps students feel more confident and supported in their first quarter. It is also a great way to make friends, enroll in popular courses and meet some of the best instructors! This special program also allows you to register early for FIGs courses, starting May 19. Visit the FIGs website for more information.
- Viking Launch offers incoming freshmen a strong, focused start up to college life at Western. The program brings incoming freshmen to campus seven days early to beat the hustle and bustle of the fall move-in while preparing them for a successful Western experience. Participants will be immersed in Western life by completing a two-credit preparation course or thematic seminar, a community service learning project, college success workshops, recreation activities and more. Find out more at the Viking Launch website.
- Refer to Western's website for specific departmental information or contact the campus operator at (360) 650-3000.
- Check your email and postal mailbox regularly as you will receive information related to interests identified on your application for admission as well as other information about Western.
If the Admissions staff can be of assistance at any step of the way, feel free to contact us directly at email@example.com or (360) 650-3440. We can help connect you to others on campus and also are available Monday through Friday, 12pm - 2pm for drop-in appointments (no advance arrangements are necessary).
3. Plan Your Finances
Western is nationally recognized for providing excellent education at an affordable cost, with Forbes, Kiplinger and Washington Monthly magazines ranking Western as a top value in education.
As you review estimated annual expenses, it is helpful to know that payment for tuition, fees, housing and meals is due at the start of each quarter. Also, remember that costs for transportation, books, supplies and personal expenses can be reduced depending on your lifestyle.
If you plan to apply for need-based financial aid, you need to submit the online Free Application for Federal Student Aid (FAFSA). Fortunately, you only have to file one FAFSA for all of the schools you're considering. The FAFSA4caster is a financial aid estimator that can tell you roughly what to expect for need-based financial aid. Go to www.fafsa.ed.gov now to apply for a PIN so you can get started with the online application when you're ready. And, be sure to include Western's Federal School Code on your FAFSA so we receive your results: 003802.
Western's Financial Aid Priority Deadline is February 15; applicants submitted after the priority deadline will receive full consideration as long as funds are available.
All first year scholarships and financial aid offers for on-time applicants will be sent out by the end of April.
Your application for admission also serves as your application for most of Western Washington University's scholarships. We encourage you to seek out external scholarship opportunities through your high school, community organizations and local businesses. You can also look at online scholarship search sites such as:
- TheWashBoard.org (for Washington residents)
- CollegeBoard
- FastWeb
Many students help to cover college expenses by working on campus or in the Bellingham community. Refer to Western's Student Employment Center for related information.
4. Find a New Home
Living on campus can really enhance your overall college experience. More than 90% of Western's freshmen live on campus, so you should definitely consider doing so. Take virtual tours of our 16 residence halls and submit your housing application online by the priority deadline:
- May 1 - Fall Quarter
- December 1 - Winter Quarter
- March 1 - Spring Quarter
Tip: Connect with potential roommates using WWU's MyRoommate, the You're In! WWU New Students 2014 Facebook Group, and the WWU On-Campus Housing Facebook page.
5. Prepare for Orientation & Registration
The New Student Services/Family Outreach Office hosts orientation sessions for new students before classes begin. Orientation programs include: orientation, academic advising, course registration, general interest sessions, and other seminars to get you prepared for Western. Fall Quarter: Summerstart is a 2-day orientation program for new Fall quarter freshmen that occurs every year in August; detailed information will be sent after the May 1 enrollment confirmation deadline. Winter and Spring Quarters: Orientation for Winter and Spring quarter freshmen occurs the day before classes begin; detailed information will be sent after you submit your enrollment confirmation fee.
The following list includes items you'll need to take care of before you get to campus:
- Activate Universal Account: After you have confirmed your intent to enroll at Western, you will need to activate your Universal Account. This is especially important because you won't be able to make your Summerstart reservations or register for classes without it. Your Universal Account provides technology resources to enhance your academic experience, including the myWestern web portal and a web-based email account, on-campus computer labs, personal storage on network servers, wireless internet access and laptops available for check out. Students are required to check myWestern email regularly, as official university correspondence will be delivered to myWestern email accounts.
- Measles Immunity: Proof of measles immunity is required for all students born after January 1, 1957. This document must be on file with the Student Health Center in order for you to register for courses. Detailed instructions will be provided after enrollment confirmation.
- Math Placement Test: Take the Math Placement Test (MPT) in the spring during the Mathematics Testing Program when math skills are fresh and there is a discount on the testing fee. Students who live in or near Washington can take advantage of the testing program prior to attending orientation. Otherwise, be sure to take the MPT at Summerstart, Transitions or Fall Orientation. Believe us, waiting is take the MPT is not a good idea, so make your plans now! See MPT FAQs
- Final Transcripts: Be sure to make arrangements for your high school to submit a final transcript, including your graduation date, as soon as it is available and no later than July 15.
- College Credits: If you plan to receive college credit for AP, IB, or Cambridge International exams and/or college coursework completed during high school, refer to the information at the Running Start and other college credit website. It is your responsibility to insure that official scores and/or transcripts are received in the Office of Admissions by July 15. Every effort will be made to provide you a transfer credit evaluation prior to course registration.
- Academic Planning: It is never too early to begin planning for your academic future and we encourage you to visit the Academic Advising Center as it includes information about the many academic resources available to Western students. You can view the General Course Catalog online as well.
6. Tie Up Loose Ends
- Please let us know about email or mailing address changes as soon as possible by emailing email@example.com. Be sure to include your full name and Western ID number.
- Western is a residential community where you don't need to have a car and using alternative methods of transportation is encouraged. Learn more about transportation options on campus:
- Bicycles: Bicycles are the preferred form of transportation on campus and there are over 900 parking spaces within the academic core. All residence halls provide bicycle storage, and there is a student-run bike shop at Western's Outdoor Center that provides access to bike tools, bike repair, and bike parts and supplies. You can register your bicycle through University Police.
- Bus Pass: Students taking 6 or more credits are allowed to use their student ID as a bus pass on the Whatcom Transit Authority (WTA) system. Buses run regularly throughout campus, downtown and Whatcom County. Most students choose to take the bus over driving a car to get around town.
- Parking Permits: While limited parking is available on campus, you can expect to pay about $275 for an academic year parking permit. See the Parking Services website for rates and permit information.
- Zipcar: Western has partnered with Zipcar to bring self-service, on-demand car sharing to the area, with discounted hourly rates for students, faculty, and staff.
- Students who intend to access services provided by disAbility Resources need to make contact with them prior to enrollment to insure timely coordination of services.


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Unique 2 way Rental/ Relax, Reflect, and Recharge at Rocky' in Lake Anna
- bedrooms 4
- baths 2
- sleeps 8
- pool no
- hot tub no
- pets allowed no
- type House
- community
rates (USD)
/ night
$ 950 - $ 1,700 / week
vacation rental description
Relax, Reflect, and Recharge are the words to express the aura of this
secluded, 7 acre retreat that is surrounded with mature hardwood
trees, as well as open pasture, nestled on a deep water, open cove.
You'll immediately begin winding down as you enter Stagecoach Road,
that was originally used in the 1800's to cross the river. It has
been maintained in it's original state, and it initiates your
peaceful adventure to experience nature and the lake, at your desire.
"Rocky's Run" will allow you to take a breath, open a bottle of
complimentary Lake Anna Wine, and catch the magnificent sunsets.
With our cottage-like accommodations, complete with 2 bedrooms, 1
bath, w/d, fireplace, direct tv/xm radio with surround sound, dvd
library, and a fully equipped kitchen, you will feel right at home.
Enjoy the gas grill and pic-nic table, while listening to songbirds
on our feeders, or catch a glimpe of an occassional wild turkey,
or deer passing through.
Our gazebo deck is another sanctuary for relaxing. Fire up the
chiminea, watch for bald eagles and fall asleep in the lounge chairs
as the enchanting sounds of nature intoxicate you.
If boating, swimming or fishing is to your liking, walk our gentle,
sloping trail to the boathouse with a screened in porch, with ceiling
fan, refridgerator and hammock. Watch for beaver, ducks, geese, and
herons. Find that huge cat-fish that always eludes our lure. Night-
time in the screened porch exemplefies the romance of this rental
and the lake.
Don't miss this opportunity to experience what so many renters
desire.....a chance to rejuvinate your body and soul.
By the way, full moons rising, sunsets, and stars you've never seen
before, are absolutely no charge!
vacation rental location
property availability
- dates with deals
- unavailable dates
Last modified on 07-21-2014 at 6:11 PM.
email owner view full calendar
tom doss 2403513024
house rental amenities
Both masters have/"Pillow-Top", queen beds, 2ndbr/twin beds, both baths bath/tub-shower,w/d,a/c,
gas fireplace in one section , ceiling fan, stove micro.,d/w, fridge, coffee-maker,
blender, mixer, waffle maker, pots/pans, etc.,. dvd library, xm,wi-
fi,direct tv, Billiards for 2 families rental only board games, eclectic group of books, gas grill, pic-
nic table, screened in gazebo/deck, chiminea, sandy beach/boardwalk,
boathouse/dock/fishing deck, screened in porch with hammock, fridge,
ceiling fan, ample elec outlets. pool table for 2 fam only
activities and attractions in Lake Anna Virginia
boating, skiing, tubing, jet ski rental very close by.
Lake Anna Marina less than 5 minutes drive time.
Fishing, swimming, horse shoes, hiking at lake anna state park,
within ten minute drive, Lake Anna winery within 5 minute drive.
Blue grass festivals, antiquing, historical cival war sites,
shopping in Fredericksburg boutiques, 45 minutes to Richmond,
historical Charlottesville, Monticello are 45 minutes away.
Amusement park 30 minutes.
Blue ridge mountains are 45 minutes drive. Luray Caverns 90 minutes
away. Busch Gardens/Williamsburg 90 minutes.
golfing, museums, various restaurants.
vacation rental rates
Short Week (mon.-fri.) available
Inquire for certain holiday rentals at extra charge.
rates depend on number in party/number of nights/time of year/holidays/week ends
ENTIRE LOWER LEVEL SLEEPS 8-10 (PRICING ABOVE) VARIES WITH TIME OF YEAR, HOLIDAYS, NUMBER OF NIGHTS....( 2 MORE BRs + ANOTHER BATH, LARGE FAMILY AREA, BILLIARDS, WET BAR, 50" SURROUND SOUND, DIRECTV, WIFI, Security deposit is required. (amount dependent on length of rental/ one family/two family
rental insurance/$49 for $1500 required
Reservation Payment:
An advanced rental deposit of 50%, upon making a reservation, is
required immediately upon reserving. Final payment 30 days before arrival.
Other circumstances may require an immediate deposit.
Final Payment:
Balance must me made no later than 30 days prior to arrival date.
Check In/Out:
Check in is no earlier than 2:00 pm
Earlier check in may be poss.
Check out is no later than 11:00am.
tom doss 2403513024
accepted payment methods
Prior to paying a reservation deposit, always verify payment instructions by calling the phone number displayed on this listing page. By contacting the owner directly and paying by an approved method - credit card, paypal, check or bank transfer - your reservation payment will be protected up to $1,000.Learn more in our Security Center
Top things to do in Lake Anna
- Boating/Fishing/ water sports
- State park/Hiking/bike riding
- Wineries/Golfing/Antiques
- Historical Fredericksburg/Monticello
- Richmond/Luray Caverns/Kings Dominion
Top things to do on a budget
- Parks/petting zoos/wineries
- nature trails/picnics/
- music festivals/boat shows
- fishing tournaments
- historical tours
Top things to do with a family
- boating/fishing/Fredericksburg
- Kings Dominion
- Busch Gardens/Skyline Drive
- Luray Caverns/historical Culpepper, Va.
- Octoberfest at wineries
tom doss , owner


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Darwin's on 4th
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Darwin's on 4th
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1525 4th Street
Sarasota, FL 34236
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$30 and under
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Darwin's on 4th Details
Dining Style:
Casual Dining
(941) 343-2165
Hours of Operation:
Dinner: Sunday - Tuesday: 5:00pm - 10:00pm Wednesday - Thursday:5:00pm - 11:00 pm Friday - Saturday: 5:00pm -1:00am
Payment Options:
AMEX, Discover, MasterCard, Visa
Peruvian, Global, International, Brewery
Executive Chef:
Darwin Santa Maria
Dress Code:
Business Casual
Accepts Walk-Ins:
Additional Details:
Bar Dining, Bar/Lounge, Beer, Counter Seating, Entertainment, Full Bar, Gluten-free Menu, Happy Hour, Late Night, Non-Smoking Restaurant, Private Room, Takeout, Wine
Open to customer's need.
Wednesday 8:00pm to 11:00pm Undr8ed - Contemporary Hip Thursday 8:00pm to 11:00 pm Ben Hammond - Contemporary Hip Friday 8:00pm to 11:00 pm Bryan Spainhower - Classic Guitar Saturday 7:00pm to 10:00 pm De Corazon - Latin Jazz Fusion Trio
Special Events & Promotions:
4/19/2012 Beer & Food School at Publix on University. 4/21/2012 SRQ Film Festival after party 11:30 pm. 4/28/2012 St. Pete Anna Faiola Model Casting.
Getting there
A word from Darwin's on 4th
Urban Street Food and Brewery.
Foodspotting photos
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Awards voted by OpenTable diners
Diners' Choice Winner
Best Overall
Diners' Choice Winner
Best Food
Diners' Choice Winner
Fit for Foodies
Darwin's on 4th -
Best Restaurants in Sarasota
Diner Reviews
We sat at the food bar and were
entertained the whole evening. The good was so perfect. It is definitely one of my favorite places to eat in Sarasota. We have been several times and it is consistently excellent!"
Dined on 8/23/2014
An all round positive experience.
Accommodating to gluten free."
Dined on 8/23/2014
Food was inventive and very well
prepared. Nice selection of drinks; home brewed beer, full bar, after dinner drinks. Overall a very nice dining experience."
Dined on 8/23/2014
Darwins on 4th is one of our go to
places. We know it will be welcoming, the service is great and the food fantastic."
Dined on 8/23/2014
My first time to Darwins and we
had friends from South Africa visiting. The quality, presentation of food and staff friendliness made the night one to remember. All four of our group chose different items from starters to dessert and we all were quite pleased! We will definitely be back. For once we all felt like we got exactly as we were expecting!! Yea !!!"
Dined on 8/20/2014
We had a great time at Darwin's.
We were celebrating an anniversary so wanted a more up-scale restaurant. This place has exceptional food and the service was great. We loved the atmosphere and decor. They had live music in the bar area, but we were seated near the kitchen where you could watch the cooks. Next time I think we would like to sit where we can watch the band, but overall, would definitely recommend this place!"
Dined on 8/16/2014
Food is diverse and full of
flavor. Ambience is very warm and makes you feel like you are in South America. If there was any doubt about authenticity, the Pisco Sour cured that. Pisco is not a common drink in the US. This one was made just like the ones I have had in Peru. Great place. Can't wait to take some friends there."
Dined on 8/15/2014
We make a point of coming here
while on vacation. The food is fantastic. The spiced porter is one of the best I've had. The people who work there are friendly and very attentive! I love Darwin's."
Dined on 8/15/2014
Food was well presented, cooked
perfectly, and delicious. Outstanding dishes. Weak point would be their home brewed beer. Service was excellent."
Dined on 8/8/2014
I'm fairly new to the area and the
food and service at Darwin's were the best that I have had in Sarasota. The flavors were amazing and the presentation was excellent. I had a chance to talk with Owner/Chef Darwin briefly as he was orchestrating the activity in the open kitchen and he was open and friendly. Without a doubt Darwin's is now my go to spot for taking out of town guests and family. My only surprise was the dessert that they called flan which was more of a chocolate mousse. So be wary if you are looking for the traditional flan to cap off the meal. It was tasty but not the light finish that I was hoping for."
Dined on 8/8/2014
We wish they would bring back
their strip steak with truffle fries. It was our favorite dish. Still, there are plenty of good items to choose from on the menu. Our waitress was nice, and our meals were terrific."
Dined on 7/31/2014
Darwin's continues to impress me
every time I dine there. They have wonderful service to compliment their outstanding food. You can't go wrong with anything on the menu!"
Dined on 7/31/2014
What should have been a wonderful
dining experience was marred by poorly trained front-end staff and having to yell across the table to be heard. The quality and cost of the food was not in keeping with the ambiance of the place."
Dined on 7/26/2014
I took my son his wife and
children as well as my wife to dinner here. The food was fantastic. We had cerviche for starters the beef and mix to. We had a variety of dishes but mostly the skirt steak it was outstanding the kids ate everything but the plates. The adults had some of the special cocktails and evryting drink wise was to perfection."
Dined on 7/26/2014
Good food with interesting
flavors, but menu has been Americanized. Music was nice, but too loud to talk over"
Dined on 7/22/2014
Fabulous food and the home brews
match the food. If you want the quality without the noise go a little earlier. Good music after 8 on Saturday's"
Dined on 7/12/2014
My fiance and I were having our
anniversary dinner there on Monday, July 7th. The staff was truly amazing. We had the perfect table, our server was friendly and attentive without hovering. (She should be commended for the excellent service she provided!) Words cannot describe how good the food was. It was a truly magical night, and they made us feel like celebrities. I already loved Darwin's, but after Monday night, I love it even more."
Dined on 7/7/2014
Very tasty, excellently presented
food. Staff, in particular our waiter "Jordan", was very attentive. It was fun watching the cooks at work in the kitchen. The pairing of beers with the Savor Sarasota menu was a very interesting experience. All in all an excellent evening."
Dined on 6/21/2014
We wanted to hear the guitar
music, but other reviewers have warned about the noise level in (and above) the bar area so we ate in the separate dining area. Unfortunately, the noise level there was so high we couldn't hear the music, nor could we have a pleasant conversation. My gluten-intolerant wife enjoyed the Wahoo Tiradito and the Risotto and my Sirloin Burger was very good (and huge). Very nice meal presentation. I had a flight of their craft beers, which was interesting but contained too many unusual flavors for my taste. I will stick with my regular IPA. Attractive decor with very good food and service. Overall an above-average restaurant for Sarasota."
Dined on 6/21/2014
In Sarasota on business and
couldn't believe I found a Peruvian restaurant! EVEN better a wonderful one with a server who is a native. In fact, most employees looked Peruvian!! Piscou Sour!!! Try one! Daniela even knew where we could purchase Piscou. Tried the Ceviche/Tiraditos sampler dish (your choice, but I had...Mayan shrimp, Beef ceviche and tuna Tiradito...amazingly different flavors, just the right portion for me. My husband really enjoyed the grilled sea bass with black bean sauce and other Peruvian accompaniments, including huge kennels of roasted corn. Also, try the Kalken Cabernet Sauvignon. Live music and not too loud in the back where we were seated."
Dined on 6/20/2014
The service is always
professional, the food is fresh and interesting, the drinks are fabulous!"
Dined on 6/16/2014
The restaurant was quite
interesting, with all the touches of copper and wood. The (I believe) owner seated us and was not upset because one of our group wasn't able to attend at the last minute. He put my walker right near me (nice to have access to should I need to use the rest room). The waitress was adorable, helpful and knowledgable. The portions were not aimed at long distance truck drivers - they were just the right amount. We went for "Savor Sarasota", but I know we will be back, and soon, as it was a most pleasurable experience."
Dined on 6/14/2014
We went to the restaurant because
it was part of the early June "Savor Sarasota" promotion. We were disappointed that we had to ask our waitress for the special-price menu instead of simply being given it. Our service was prompt but not particularly friendly. The micro-brewed beers offered as pairings with our entrees and desserts were excellent. The wine list is excellent."
Dined on 6/14/2014
Excellent food. Great use of
flavors everything merried well together It was a shame the beer of my choice ran out after the first glass though!"
Dined on 6/13/2014
It is very difficult to rate a
restaurant when it is Restaurant Week. I find it frustrating that most of the restaurants that participate don't give you the special menu. That being said..the meal was great but very small I will try Darwins again because I think it was due to the Savor Sarasota Week"
Dined on 6/13/2014
Savor Sarasota menu was excellent.
We especially enjoyed the craft beer pairings; a nice touch!"
Dined on 6/13/2014
During Restaurant Week, we took
the opportunity to try new restaurants in our area. I am so glad that we chose Darwin's! The restaurant really had so much character and atmosphere. We sat in the loft area where we had a great view of the tv, the musicians and most of the other diners. Our server was Darby (I think). She was wonderful! We ordered from the prix fixe menu. Everything was excellent and the portions were the perfect size. They also had a very good wine list. We eat out a lot and this will become one of our regulars!"
Dined on 6/13/2014
From the first time we dined at
Darwin's we fell in love. The atmosphere is romantic but fun, and the food is just amazing. Chef Darwin has outdone himself on the beer pairing so perfectly with his elegant menu. Love the presentation of dishes! Sometimes I feel badly destroying them!"
Dined on 6/12/2014
I always try something different
when we go to Darwin's as the mixture's of flavors and textures is outstanding."
Dined on 6/9/2014
We tried Darwin's as part of Savor
Sarasota and we WILL be back often. It had a diverse menu with Peruvian influence. And their own microbrews that were paired perfectly with each dish were exceptional. They have an inviting bar/lounge area to come and have a drink and snacks. For dinner next time I want to try sitting at the round to watch the chefs do their final preparations. Lots of fun."
Dined on 6/9/2014
Nice location. Food was great.
Just a little loud for my taste. Hard to hold a conversation. "
Dined on 6/7/2014
Delicious food, great atmosphere,
interesting and well-made cocktails, Darwin's was a great place for a night out! Good for group or romantic dinners! My only negative comment was the service could have been a little better. Server was perfectly nice, but seemed like it took a while to get order in. Food was outstanding and I already know what I'm going to order when I go back!!"
Dined on 6/7/2014
This was a first time for us both
at Darwins and their food type, it was marvellous."
Dined on 6/6/2014
This restaurant was a gem! Great
service, menu with many delectable options, great ambiance. From the ceviche to the meal, we enjoyed every bite!"
Dined on 6/6/2014
The taste of the food was pretty
amazing. The portions were not huge. More of a tapas size."
Dined on 6/6/2014
food is great, service
outstanding. Noise level bad"
Dined on 6/4/2014
Bar scene was hopping and food was
good if not great. Service was a bit slow but ok. "
Dined on 6/4/2014
All the food was great, with
impressive presentation. The service was impeccable! It was quite a treat to visit such an impressive restaurant while visiting Sarasota! Loved it! The owner took the time to conversate and share his interesting story about their brewery. We will definitely return when we're in The area."
Dined on 6/4/2014
This restaurant delivers
delectable, artfully prepared dishes. The server was professional and gracious. Happily we have found a neighborhood restaurant worthy of repeat visits, there are too few in Sarasota."
Dined on 6/3/2014
I travel to Sarasota about 4 times
a year for work. I am eating at Darwins on 4th 2x this trip because its soooooooooo good. I do not have anything but praise for the resturant, the food and staff. I had the pleasure of speaking with Darwin and found out he is a Johnson and Wales grad[to me the proud Mother of a Johnson and Wales grad that explaned a lot]. Thanks for a great meal"
Dined on 6/2/2014
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Dusty est un avion qui rêve de voler en compétition, au milieu des avions les plus rapides au monde. Mais Dusty n'a pas l'étoffe d'un champion, et en plus, il souffre du vertige. Il décide donc de faire appel à un as de l'aéronautique pour l'aider à se qualifier et à affronter le redoutable tenant du titre. Dusty va déployer ses ailes...
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Dusty est un avion qui rêve de voler en compétition, au milieu des avions les plus rapides au monde. Mais Dusty n'a pas l'étoffe d'un champion, et en plus, il souffre du vertige. Il décide donc de faire appel à un as de l'aéronautique pour l'aider à se qualifier et à affronter le redoutable tenant du titre. Dusty va déployer ses ailes pour relever, sous les yeux des spectateurs du monde entier, le plus grand défi de sa vie.
Pour accéder à l'horaire, entrer votre code postal afin de trouver les cinémas où ce film est à l'affiche dans votre région.
Disney's Planes arrives as a spin-off of Pixar's Cars and on the heels of the most critically disappointing movie in the current Pixar filmography: Cars 2. Under the shadow of Pixar's least appreciated work, one can forgive low expectations for yet another 3-D CGI kiddie movie set in ''the world of Cars.'' The fact that it has been made by the direct-to-video Disney production arm DisneyToon Studios will add another strike to the animated movie's prospects, especially considering director Klay Hall's only other film is another Disney spin-off: the direct-to-video Tinker Bell and the Lost Treasure. Who can blame any knee-jerk judgments based on these factors? But to take any critical assessment of Planes based on such prejudices does this amiable, if flawed, animated romp a disservice.
Though Planes is not innocent of some rather lazy, hackneyed Disney tropes, more often than not, it transcends expectations by taking its time with its hero's steady rise to self-actualization. Planes follows Dusty (Dane Cook), a prop engine plane with aspirations to be ''more than just a crop duster.'' While flying low over a field of corn, Dusty daydreams of winning an aerial race around the world. His mantra: ''I'm just trying to prove maybe I can do something more than I was built for.'' It's the classic underdog story fraught with overcoming conflicts outside (an experienced, conniving and bullying racer named Ripslinger voiced by Roger Craig Smith) and within (a fear of heights).
Though apparently concocted as a direct-to-video cash-grab, Planes deserves the big screen, 3-D treatment more than many other 3-D films. The movie features three variations of flight scenes: the third-person perspective looking on at planes zipping toward the screen, the first-plane rollercoaster-like experience from the Windshields of the planes and the stomach-dropping depiction of poor Dusty's vertigo. The fact that higher-definition projection has improved the 3-D effect to decrease edge blurring makes this one of the better 3-D films ever made.
Key to Planes' success comes from its reserved pacing. It actually spends quality time with its characters. Exhilarating race sequences are varied and never feel overlong and unending. In a race around the globe, the director knows how to hold-off on the throttle of indulgence and save room for the next heat, as no single race sequence overstays its kinetic drama to devolve into a droning series of set pieces that grow tiresome. It also does quiet moments quite nicely, indulging in some CG magic hour backdrops and a playful pallet of varying light sources including some rather atmospherically nostalgic effects like neon glows and incandescent lights.
Though these more serene moments may play well to adults, it may test the patience of the little ones in the film's target demo. There are moments, especially before the race commences, where the anthropomorphized vehicles share conversations featuring commentary that will fly over the heads of younger audience members. It may make for some rather nice moments of character development for parents hoping for a little more substance, but on the other extreme, parents will have to endure a few moments of the laziest type of crude humor (a fart joke appears two minutes into the action, and it's not the only one).
However, the biggest hit against Planes is how it reinforces stereotypes disguised as character color. Coupled with plane bodies stylized to depict cultural and racial stereotypes, including, most offensively, a chunky Mexican entry decked out in a luchador mask named El Chupacabra (Carlos Alazraqui), it makes for a rather mixed message by Disney. It's not just a cheap gimmick, but a harmful reductive trope that reveals the hypocrisy of Disney's message that marginalizes more than celebrates diversity.
So often, Disney movies feature unlikely heroes rising up against bullies, however these cringe-worthy, short-sighted characterizations only serve to reinforce the differences that create such easy targets for bullies. It's ironic that Planes' protagonist works so hard to overcome prejudice to rise above social classification while the film itself indulges in the same disregarding behavior its hero attempts to transcend. Leaning on cultural stereotypes is the film's biggest if somewhat subtle offense. Otherwise, it should make for a worthwhile distraction as far as 3-D experiences for the family. Lest you feel prejudicial as far as the filmmakers' credentials behind a sub-label within the Disney Studios umbrella, the film still deserves the benefit of the doubt.
Follow Hans Morgenstern on Twitter @Indieethos
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The indictment charges 48 counts each of health care fraud and wire fraud. It seeks forfeiture of $1.3 million from McCutcheon as proceeds of the frauds.
Each of the healthcare fraud counts carries a maximum punishment of ten years in prison and a $250,000 fine. Each of the wire fraud counts carries a maximum penalty of 20 years in prison and a $250,000 fine.
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Star Point on Snow Pond in Belgrade Lakes
- bedrooms 2
- baths 1
- sleeps 4
- pool no
- hot tub no
- pets allowed yes
- type Cottage
- community Sidney
rates (USD)
/ week
$ 5,400 - $ 5,400 / month
vacation rental description
Prime Time Weeks Available in July! Come for one week or two, July 5 to July 12, and July 19 through August 2. It's a GREAT time for a Maine Vacation!
Spend a week or more at Star Point, and experience summer in Maine, the way life should be! Our comfortable cottage is situated at the wide end of Messalonskee Lake (aka Snow Pond), in the famous Belgrade Lakes chain.
Located at the waters edge, our camp was built in 2004 and features an open floor plan with 170 degrees of lake views. Two decks and a porch offer plenty of outdoor seating in the sun or in the shade - where you will enjoy spectacular sunsets, the call of the loons, and gorgeous night skies.
Inside, the kitchen is a cook's delight and you can't beat those views. If you would rather just toss something on the grill as you toss a salad, that will work too! The main bedroom is on the first floor, with a king-sized bed, 2 dressers, and large closet. The bath is small but efficient, and is also on the first floor. Kids enjoy the loft bedroom with its cozy nook where they have a birds-
eye view of the lake and first floor. The loft has a queen-sized bed and room for sleeping bags, plus a computer with Internet access.
The property is nestled in a small cove with a sandy bottom, great for swimming, fishing, or just floating. We have a small dock for your boat and you are welcome to use our canoe.
For fishermen, Snow Pond is a dream spot. The lake was named one of Americas 150 Best in 2007
according to Field & Stream. Trout, Bass and huge Northern Pike, are all here waiting for you to cast a line.
Well-behaved dogs allowed; per town ordinance, all dogs must be leashed at all times.
vacation rental location
property availability
- dates with deals
- unavailable dates
Last modified on 05-8-2014 at 6:46 AM.
email owner view full calendar
Tim & Lauren
cottage rental amenities
Master bedroom has a king size bed w/Pillow Top Mattress
The loft bedroom has a queen bed
Full bathroom with oversized shower
2 large closets
Rinnai Gas Heater for those rainy days and cool summer evenings
Fully equipped kitchen with gas cook top/electric oven, microwave, toaster, coffee maker,
refrigerator w/ice dispenser, cookware, flatware, kitchen knives and dishes
Flat Panel TV w/DirecTV and DVD player
High Speed Internet access with wireless internet
Outside you will find a deck, gas grill, picnic table and more
Canoe with life jackets and paddles
Private dock
Public Boat launch area is 3 minutes away
Cell phones work well in area.
Linens: blankets and pillows provided, bring your own sheets & towels
activities and attractions in Belgrade Lakes Maine
The Maine Coast or the Western Mountains for exploration or shopping in Freeport or Bangor are all within an hour away. Colby College and its fine Museum of Art are less than 12 miles away in Waterville, which hosts the Maine International Film Festival every summer. Along with the Belgrade Lakes the Kennebec River offers Kayaking, Canoeing and fishing. 15 minutes to Augusta or Waterville with shopping, restaurants, cinemas and to I-95. Several public golf courses within 30 minutes drive.
www_belgradelakesgolf_com, www_natanisgc_com, www_watervillecountryclub_com
vacation rental rates
Rate Calendar for 2013 Season:
Spring $1200 week before June 21st
Summer $1500 week June 21st - September 22nd
Fall $1200 week after September 22rd
Partial week rentals available May, June and late Sept. Inquire for rate.
Full week rentals only July, August and early Sept.
Check-In: Saturday after 2 PM Check-Out: Saturday at 10:00 AM Sharp!
We require a Security Deposit of $500.00 within 7 days to confirm and hold your reservation, with Full Rental payment due 30 days prior to arrival. The security deposit will be returned within seven (7) days of checking out, if the home is left as you found it.
Cancellation policy: We will retain the deposit if we are unable to re-rent your week(s).
Tim & Lauren
accepted payment methods
Prior to paying a reservation deposit, always verify payment instructions by calling the phone number displayed on this listing page. By contacting the owner directly and paying by an approved method - credit card, paypal, check or bank transfer - your reservation payment will be protected up to $1,000.Learn more in our Security Center
Top things to do in Belgrade Lakes
- Golf at the Belgrade Lakes GC
- Visit the Maine Lakes Resource Center
- Dine at the Village Inn
- See the view from Blueberry Hill
- Hike in the Kennebec Highlands
Top things to do on a budget
- Boat, Fish, Kayak, Bike & Swim
- Kayak a section of the Kennebec River
- Visit the Colby Museum of Art
- Star Gaze on the front deck
- Sunday Concerts at New England Music Camp
Top things to do with a family
- Popham Beach State Park
- Pemaquid Beach State Park
- Eat Lobster at Young's in Belfast
- Visit the Penobscot Marine Museum in Searsport
- Visit the Maine State Museum and Viles Arboretum in Augusta
Tim & Lauren , owner


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sfai news
SFAI Announces Appointment of Aziz + Cucher as Artists-in-Residence and Guest Faculty to Lead Low-Residency MFA in Studio Art Program
The San Francisco Art Institute is pleased to announce the appointment of SFAI alumni Anthony Aziz and Sammy Cucher as artists-in-residence and guest faculty to lead the Low-Residency Master of Fine Arts (MFA) in Studio Art program for Summer 2014. Known to the art world as Aziz + Cucher, the collaborative duo are renowned pioneers in the realms of digital media, photography, and multichannel video installation.
Left: Aziz + Cucher, Maria, 1994–95. C-print, 50 x 40 inches. Courtesy of the artists.
Right: Aziz + Cucher, Chris, 1994–95. C-print, 50 x 40 inches. Courtesy of the artists.
Graduates of SFAI's MFA program (Aziz, MFA Photography, 1990; Cucher, MFA New Genres, 1992), the team earned critical acclaim with their breakthrough series Dystopia (1994–95), a series of portraits digitally manipulated so the subjects' facial features appear to have turned inward. The work is considered pioneering as it was one of the first to use Photoshop in a strictly fine arts context, paving the way for contemporary digital explorations and other hybridized photography/new genres practices in contemporary art. Later works continued to conceptually engage the interplay between the human and nonhuman, and the natural and technological, with imagery drawn from landscape, architecture, and the body.
Aziz + Cucher's work has been exhibited extensively, including at venues such as the 1995 Venice Biennale, the 1999 Biennale de Lyon, the MIT List Visual Arts Center, the New Museum of Contemporary Art, SFMOMA, and the International Center of Photography (ICP), among numerous other international centers of art and culture. Their work is represented by Clampart, New York; Gazelli Art House, London; and Artereal, Sydney. Both Aziz and Cucher are presently on the faculty at Parsons The New School for Design, New York.
The artists have noted their investment in SFAI, and their eagerness to contribute to an educational community that profoundly nurtured their own creative practices at formative and pivotal moments in each artist's development. As students in the 1990s, the artists were drawn to the Institute's legacy of experimentation and innovation, as well as the interdisciplinary nature of the curriculum:
"It was a very welcoming community for people from all over the world to come together to discover and forge new paradigms of art-making. It was essentially a graduate laboratory that fostered a sense of real possibility, and at the time, there was not a lot of collaborative work being created in the art world; however, we were fortunate to discover synergies between our disciplines and disparate cultural backgrounds, and we were able to merge our practices into a single body of work. Because of the way the Institute was designed—and still is structured—that kind of unexpected synergy was able to occur."
The artists commented further: "It is emotional for us to consider coming back and spending time at SFAI. There's a sense of duty that we feel, having gotten so much as students, to be able to give something back and do something meaningful for the school and its current student body."
To learn more about Aziz + Cucher, visit: www.azizcucher.net
The Program
SFAI's Low-Residency MFA in Studio Art program provides an exciting interdisciplinary context in which emerging artists develop and refine their work while engaging the historical, theoretical, sociopolitical, and creative concerns of the contemporary moment. Founded on the principle that critical inquiry and experimentation are at the forefront of art-making, the program fosters students' use of their own questioning to generate a sustaining and vital creative practice.
The three-year program offers the rigor of a full-time MFA program in a flexible format ideally suited for artists who wish to develop their work without sacrificing a professional career or commitment. Students work with faculty during intensive eight-week summer sessions in San Francisco, and independently—with guidance from artists in their home communities—during the fall and spring. Summer sessions combine critiques, art history and critical studies seminars, visiting artist lectures, and individualized tutorials to create a comprehensive studio- and research-based curriculum. The program culminates with the highly celebrated MFA Exhibition.
The priority deadline for applications for Summer 2014 is January 15, 2014. To speak with an admissions counselor, email: email@example.com


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Mobile Products Support
Woodward, OK 73801
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text: Family Movie Matinee - Divergent You've read the book, now watch the movie on the big screen! We will be showing Divergent (PG-13) on Saturday, August 30th at 2:00pm. Enjoy popcorn and lemonade provided by The Friends of the Library during the film. Date: Saturday, August 30, 2014 - 2:00pmEvent & Program Ages: AdultsChildrenTeensEvents & Programs Locations: Pomeroy Public Library


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I am in the planning stages of designing a workbench for the shop. It will mainly be used for light to medium work. What are some of the features that i should "design" into it. I plan on having a vise and a grinder in the corners. Does anybody have any suggestions or advice?
Thanks in advance,


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A Lauderdale County health inspector reported two critical violations reported here at the Peking Chinese Restaurant in Florence as they scored an 84.
The inspector reports an employee drink in a food prep area and that cut melon was nine degrees above the maximum temperature required to prevent bacterial growth in cold-holding foods.
A Marshall County health inspector reported three critical violations at the Captain D's in Guntersville as the fast food restaurant scored an 81.
The inspector reported dirty soda nozzles, dirty ice bins, open employee drinks in a cooler and a cracked ice scoop.
For all of the most recent health inspection scores, log on to the Alabama Department of Public Health Food Establishment Scores.
Copyright 2012 WAFF. All rights reserved.
1414 North Memorial Parkway
Huntsville, AL 35801
WAFF Is a Proud Member
of the Raycom Family of Stations
FCC Public File
EEO Report
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1BR Lbs Villa from$ 79 NT-by the Ocean, Beach, Pool in Lauderdale-by-the-Sea
- bedrooms 1
- baths 1
- sleeps 3
- pool yes
- hot tub no
- pets allowed yes
- type Villa
- community Villas by the Sea
rates (USD)
/ night
$ 490 - $ 1,390 / week
$ 1,300 - $ 2,900 / month
vacation rental description
There's no need for a car,ocean,beach, shops, stores, and restaurants are in walking distance.
Call for reservation tel # 1-954*604-3005 or skype: viprent4u
or visit my web site www, lbsvilla,com
or visit mi web site www, lbsvilla,com
Come relax at this beautiful beach getaway and you will be returning year after year. This elegant one or two bedroom unit is fully renovated. It includes all new furniture, linens, cookware and electronics. This lovely unit is overlooking a beautiful heated pool and is equipped with all you will need during your vacation stay.Beautifully new furnished, linens and towels provided.Griil, Private new pool & yard. Great place to relax or entertain!Steps to the beach in one of the safest cities in South
Florida,public tennisand basketball courts,and access to
sportfishing. Close proximity to over 50 public championship golf
courses. Minutes to downtown Ft. Lauderdale, Las Olas Blvd., and the
Performing Arts Center and numerous fine dining establishments. 20
minutes to Ft. Lauderdale Airport .
vacation rental location
property availability
- dates with deals
- unavailable dates
Last modified on 09-1-2014 at 10:20 AM.
email owner view full calendar
Venice Management 954 604 3005
villa rental amenities
Completely newly remodeled new furnished one bedroom,one bathroom villa.Brand new heated swimming pool,Central A/C.
Free parking, laundry room, plasma TV's in the living room and in the bedroom, DVD players, deluxe cable TV , wi-fi wireless high speed internet, central air conditioners, full kitchen, toasters, coffee makers, beautifully furnished,linens and towels provided.
Fully equipped kitchen with everything you need -microwave -stove -fridge/freezer-fully equipped kitchen-iron and ironing board -glasses -dishes -cutlery -bake ware, bowls, pots and pans.
activities and attractions in Lauderdale-by-the-Sea Atlantic Coast South
Just a 1 minute walk to the beautiful beach and Lauderdale-by-the-Sea Fishing Pier, fine restaurants and the night life of Lauderdale by the Sea. Biking, Golf, Tennis, Basketball, Miniature golf, Casino, Horse Racing, Fishing, Shopping,
Restaurants, Sightseeing, Swimming, Snorkeling, Diving, Sailing,
Surfing, Jet Skiing, Shelling & Cruise Ships (day trip or extended
stay) depart regualrly from Ft. Lauderdale;
Call for reservation tel # 1-954*604-3005
or visit mi web site www, lbsvilla,com
vacation rental rates
04/16/11 - 12/14/11 ---from---$89 per night--- $550 per week-----$1700 per month
12/15/11 -04/15/12 ---from---$140 per night---$980 per week-----$2900 per month
Call for reservation tel # 1-954*604-3005
or visit mi web site www, lbsvilla,com
(1-4 persons)
Venice Management 954 604 3005
accepted payment methods
Prior to paying a reservation deposit, always verify payment instructions by calling the phone number displayed on this listing page. By contacting the owner directly and paying by an approved method - credit card, paypal, check or bank transfer - your reservation payment will be protected up to $1,000.Learn more in our Security Center


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It's been more than five months since 37 Madera County citizens attended an orientation outlining the rigorous training schedule one would undergo to become a member of the Madera County Sheriff Department's Search and Rescue (MADSAR) team.
The orientation, presented Jan. 18 at Minarets High School by Sgt. Jim Bernardi, a 23 year veteran of the department and seven year MADSAR coordinator.
Bernardi was assisted during the half day orientation by 10-year MADSAR team leaders Mike and Brenda Perreira, Ron Vargas, and about a dozen other Search & Rescue team members and deputies. That afternoon was the beginning of 120 hours of classroom and field training for the dedicated volunteers.
Classroom curriculum included SAR management/incident organization, legal and ethical aspects, fitness, survival, safety, personal equipment, tracking, communications, search techniques, helicopter safety, rope rescue, and map and compass navigation.
In addition to their time, each trainee was responsible for purchasing the necessary equipment required, including quality back packs, walking sticks, a compass, and suggested protective gear all totaling about $500.
At the end of five month training academy, 23 of the original 37 prospects successfully completed the training and passed written and field exams.
The Search & Rescue version of "graduation," took place May 31, in the form of a "Mock Search & Rescue" operation on the 4,500-acre San Joaquin Experimental Range off Highway 41, five miles south of Coarsegold. Sheriff John Anderson welcomed the group and thanked them for their dedication and service on behalf of the citizens of Madera County.
Five search teams
The trainees were split into five search teams, each with a mission to locate a simulated lost person, while being closely monitored by a veteran team member observer. Each team was provided maps that outlined five different 45-acre search areas. Utilizing maps, hand-held Global Positioning Systems, compasses, and the skills they learned during training, the teams set-out over the dry, rolling hills to locate their subjects. All were successful.
Members of the state Military Department, including Randy Orpe of North Fork, participated with portable satellites that provide the command post with vital Internet service when in remote locations.
Another part of the operation was a portable communications room under the direction of Emergency Operations Lieutenant Tyson Pogue. Pogue and other department information specialists work with an information system called WebEOC that was implemented by Anderson in 2007.
"WebEOC is an management system that allows for real-time information sharing between emergency incident managers, command staff, first responders, emergency shelters, and other county departments during MADSAR activities or other emergencies," Pogue said. "It's an extremely versatile and powerful tool. We have even used it to stream live video during incidents allowing command staff to see first hand."
``Diverse and dedicated group of volunteers
Reasons for volunteers wanting to join the team are as varied as the volunteers themselves.
Ed Greene, who retired after a 30 year career with the California Highway Patrol, had numerous occasions to work with Search & Rescue teams.
"I knew they were looking for volunteers and were starting an academy training class back in January, "Greene said. "They only give this training every two years, so this was the perfect opportunity to become a volunteer, since I retired on Dec. 31, 2013.
Greene said he talked with a friend, Don Bartunek, about becoming a Search & Rescue volunteer.
"I was interested in riding one of the ATVs and Don was interested in the equestrian aspects of Search and Rescue," Greene said. "So we both both attended all the training classes, and it was great to have a friend going through the training together."
After 32 years of service with the US Postal Service (12 years as post master at Bass Lake, Coarsegold and Oakhurst), Kerry Abbott retired three years ago. Husband Tim worked for the postal service for 16 years in Auberry and Oakhurst, eventually retiring after serving Mariposa as post master for six years. Kerry said she has always had a personnel interest in the Search & Rescue mission.
After giving it a little thought, Kerry said she realized joining the team would offer her the opportunity to do something totally different from anything she had done in the past.
"It has also afforded me the chance to connect and develop camaraderie with a group of people over a shared passion for helping others in need," Abbott said.
Abbott said the 16 Saturdays of training was unexpectedly comprehensive.
She said the training was professionally presented and extremely well organized.
"The support offered by training leaders Mike and Brenda Perreira and Ron Vargas, along with other team members was beyond my expectations," Kerry said. "Their willingness to support the group in every way to ensure our success in the program was incredible."
Kerry ultimately realized her 'small' contribution, in combination with everyone else on the team, could result in the opportunity to save someone's life.
"What else could match the feeling of potentially playing a role in saving the life of a fellow human being," asked Abbott.
Madera County Road Commissioner Johannes Hoevertsz said he signed-up for the training to further serve and help the residents of Madera County.
"The five month commitment was well worth it," said Hoevertsz, who has been in the county road department 13 years (seven as commissioner). "The training team is world class. The diversity of experience among the recruits was an asset to the entire team. We learned excellent skills that I look forward to enhancing and putting to work to save lives and help rescue people as needed."
At 18, Amanda Miller is the youngest trainee to go through the training. Home schooled her entire life, she graduated high school online and has been working for West Coast Imaging since 2012.
An outdoor enthusiast with seven brothers, Miller loves to hunt, fish, hike, camp, and ride horses.
"I just love challenging myself and that was a big reason for joining the SAR team," Miller said. "I also wanted to join because I have the desire to do something to help people and this is a great way to do that."
Miller said the first couple of weeks of training was pretty intimidating, and being the youngest, she felt pretty secluded from the others.
"But as the weeks went by more and more people left and after a few weeks we had a solid group," Miller said. "It was a long haul, but the commitment was worth it."
Miller missed only one day of training, and that was when she accompanied her father Dave, who ran the Boston Marathon April 21.
Sheriff Anderson proud of team
Anderson said he made a commitment to professionalize the team about 15 years ago when the group was trained according to national standards.
Anderson told the group he would match the members of the Madera County Search & Rescue team against any in the state.
"I'm proud of our team for its skills, dedication and continuous training they undergo," Anderson said.
Bernardi said almost all teams in the state are now trained to the same standards.
"This is important, because when a mutual-aid call goes out, we are all on the same page," Bernardi said.
The current team consists of about 70 volunteers, with about 60% being Mountain Area residents.
There are about 70 current members on the team - about 60% Mountain Area residents and 40% from the Valley.
Perreira said it was due to the generosity of Minarets High School Principal Michael Niehoff and school secretary Patti Collins, that the entire academy, including classroom work and field training, was held at Minarets at no expense.
Once background checks are completed, the volunteers will be officially placed on the volunteer call-out list as needed.
"This group was the largest class to ever go through the training," Mike Perreira said. "The background of the individuals in this group made it clear from the start that they brought a lot of experience and intelligence to the training academy. All of this plus the training that they have received from more than 20 current SAR volunteers, will make them able to contribute to our MADSAR teams in the very near future."
The next training session will be held in early 2016, with applications being taken in the fall of 2015.
Anyone interested in joining the team, can contact Perreira, (559) 349-8903, or Sgt. Bernardi, (559) 642-3201.
New MADSAR volunteer
The latest group of volunteers to join the Madera County Sheriff Department's Search & Rescue team are:
- Tim and Kerry Abbott retired postmasters/US Air Force veteran
- Don Bartunek special investigator for the State of California
- Carol Bende retired police officer and investigator for the Bakersfield DA's office.
- Lance Boyer general construction management.
- Vic Bruno former sheriff's reserve deputy
- Dr. Jerry Chastain Kaiser Permanente
- Jerry Collins Captain, Madera County Fire Department.
- Rick Cooley retired Cal Fire Captain.
- Gary Delvin former US marine and school district administrator.
- Stephen Dougherty owner of Madera Veterinary Center.
- David Ficklin designer and engineer at the Linear Accelerator, Stanford University.
- Lynn Fullmer former reserve deputy,
- Madera County Sheriff's Office, and California state investigator.
- Ryan Fullmer owner, Fullmer's Appliance Repair.
- Frank Gilb retired after 20 year career with LAPD.
- Ed Greene retired 30 year CHP sergeant.
- Brian Hansen retired Cal fire captain.
- Johannes Hoevertsz Madera County Road Commissioner.
- Amanda Miller Yosemite High School graduate and youngest trainee at 18.
- Michael Medina nutritional science and dietetics technician, Fresno Economic Opportunity Council.
- Frank Mosca Army combat veteran and combat medic.
- Tim O'Connor US Forrest Service Hotshot supervisor.
- Tim Roche US Navy veteran, and O'Neals cattle ranch owner.
- Kenny Thome former US Marine, retired rancher and mechanic.


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Browns CEO Joe Banner told reporters this week that he won't wait long to make a decision on head coach Pat Shurmur and general manager Tom Heckert at season's end. Changes in Cleveland would surprise absolutely no one, given the club's new ownership and yet another losing season. Numerous reports have former Browns personnel man and current NFL Network analyst Mike Lombardi as a potential candidate for an evaluator's role in Cleveland should Heckert depart, with Patriots offensive coordinator Josh McDaniels a prominent name in the rumor mill for a potential Shurmur replacement.
If changes are to come, the trickle-down effect on the roster bears watching, especially at quarteback, where rookie Brandon Weeden has been inconsistent and will be 30 next October. One recent surprising personnel move was the release of No. 3 CB Dimitri Patterson. Little is known why the Browns let go of a player re-signed nine months earlier to a three-year deal with $6 million reportedly guaranteed, and Shurmur and defensive coordinator Dick Jauron's refusal to discuss the matter was especially notable. But it's clear the club likes second-year player Buster Skrine, who can fill Patterson's role at a much cheaper cost.
The Browns' organization with Banner at the helm started to come into greater focus this week with the naming of former Cowboys senior vice president / executive counsel Alec Scheiner as team president. Scheiner will run the business side of the Browns, with Banner expected to have an active role in football operations.


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Giants first baseman Aubrey Huff has been placed on the 15-day disabled list for an anxiety disorder, and has returned to his home in Tampa.
CSN Bay Area's Andrew Baggarly reports that Huff could rejoin the team and continue treatment:
Giants manager Bruce Bochy still hasn't addressed the team to explain Aubrey Huff's situation, but he plans to call the group together soon.
The veteran was placed on the 15-day disabled list because of what Bochy described as "an episode of anxiety" and already has received treatment in Florida. He'll rejoin the team Friday or Saturday in San Francisco, where he'll continue in some sort of undisclosed treatment program, Bochy said.
Baggarly goes on to say that Huff's wife has filed for divorce; he first heard about this during spring training and, after the reports of Huff leaving the team surfaced, Baggarly confirmed this through publicly-available court documents. He goes on to say:
I do not revel in discovering these documents, nor do I wish to inflict any more pain on Huff as he goes through what by all accounts is a very difficult time. Anxiety is a complex disorder that can be caused by many things, and I was careful in my story not make a direct link between the divorce proceedings and any mental difficulties that Huff is dealing with now. For most people, sure, it would be a contributing factor. But until Huff decides to issue public comments on his situation, it's not right to make any assumptions.
It's a tough call. As Baggarly writes, "It took me five minutes on my laptop to find the court records from Hillsborough County, Fla. Anyone could have done it. The court filings are public record."
At the same time, he says we shouldn't make any assumptions. So I won't; I simply pass along what's already been written.


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Most of us know that soda isn't good for us, but that doesn't mean we stop drinking it. Here are 22 financial, health, and other reasons to kick the habit.
Whole grain? Whole wheat? Enriched? While they might all sound nutritious, they're far from equal. Learn how to get the most from your grains.
Pre-prepared meals can be a great way to fit back into your old jeans...as long as you can also fit the meals into your food budget.
Eating right while traveling is quite the trick, especially when you're hanging in places that revere fried foods above all. So how can you get your greens and keep your h
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Rainbow Project charity pots PR gold (From Daily Echo)
When news happens, text SDE and your photos or videos to 80360. Or contact us by email and phone.
Southampton's Rainbow Project charity pots Leepeckgroup's PR gold
Updated 9:23am Thursday 20th February 2014 in News By Rebecca Pearson, Reporter
THEY have been providing vital support to young people for more than 30 years.
And now The Rainbow Project has won a year's support from a PR company.
The Southampton-based charity that supports disadvantaged and vulnerable youngsters in and around the city, won the Leepeckgroup Christmas competition.
They went head to head with seven other charities in the race to clock up the most votes and win a £200 donation and a year's support to help them raise awareness and boost funds.
The prize money will help The Rainbow Project provide tools and equipment to help maximise the success for youngsters using their Life Chances supported employment placement service.
Charity project manager Laura Coleman said: "We are a very small, local, young people's charity and an opportunity to receive PR from such a reputable company is invaluable to us and not something we would ordinarily have the privilege of.
"We think it is fantastic that a local company took the time and trouble to promote local charities and that Rainbow was selected for this campaign – it's a brilliant idea and makes a real difference to the local community. Thank you to Leepeckgroup and to everyone who voted for us."
Log on to the Rainbow Project at therainbowproject.co.uk.
Comments are closed on this article.