text:
Nvidia hits back at AMD's Gameworks allegations
Company reps flat out deny AMD's claims, dismissing most as simply lies.
Akitio's Thunder2 Quad review
Akitio's Thunderbolt-based external storage provides speedy transfers, but its market is limited...
What is Qualcomm's 'challenge' in China?
The semiconductor giant posts a solid quarter, but Chinese market is proving...
Microsoft's earnings show a company in transition
Revenue is up, but hardware is proving to be a big drag...
Don't Miss
'Battlefield: Hardline' delayed to 2015
Check your e-mail: Sony sends out free 'Destiny' Beta keys to select PS3, PS4 gamers
Bigger than consoles
Early access might come to PlayStation and Xbox
Update: 'Tekken 7′ announcement gets leaked, uses Unreal Engine 4, official trailer released
Every 'Destiny' beta code unlocks three download keys to share with friends
Xbox will remain a key focus for Microsoft, says Nadella
Beloved indie hit 'Rogue Legacy' slashing onto PS4, PS3 and PS Vita later this month
Report: Samsung's Gear VR headset revealed, will be modular and powered by Galaxy devices
Xbox owners only get four days in the 'Destiny' beta
Meet the Chairless Chair: a seat you can 'wear' to sit anywhere
Why didn't I think of this earlier?
iPhone 6 front and rear-shell combined give complete look at Apple's upcoming juggernaut
The 4.7″ iPhone 6 reminds us of the original iPhone (2007).
Sony Xperia M2 Aqua brings top-notch waterproofing to low-end Android sector
So far considered premium features worthy of only expensive high-end mobile devices, water and dust protection make their Western debut on an entry-level, hopefully budget-sensible Android – Sony's Xperia M2 Aqua.
Apple may sell 75 million iPhone 6 units before year's end
RBC Capital Markets notified investors today that it expects demand for new iPhones to surge so much so that Apple may sell over 75 million units by the end of this year.
Meet the noPhone, a hilarious, innovative smartphone surrogate
The noPhone may not technically be a smart device, or a real phone for that matter, but it does offer a "technology-free alternative to constant hand-to-phone contact", and so it's a truly unique… thing, with an unrivaled list of special features.
'Swing Copters', aka Vertical 'Flappy Bird', making its comeback, er, debut this week
Defying all the haters that dubbed his work a one-hit wonder affair, "Flappy Bird" phenomenon creator Dong Nguyen is back with an original new product (yeah, right), called "Swing Copters" and featuring basically the exact same gameplay as the erstwhile aviary gold mine.
iPhones with sapphire displays to hit the market next year
According to a JPMorgan analyst Apple isn't going to release iPhones with sapphire displays this year instead its setting up the stage for 2015.
Ultra-affordable $200 HP Stream Windows 8.1 laptop detailed at last, low-end specs in tow
Enough joking around and waiting for Chromebook demand to miraculously start lagging after so many great months, Microsoft is just about ready to take the bull by the horns and launch a super-low-cost Windows 8.1 rival.
Reversible USB cables may be shipped with upcoming Apple mobile devices
It is possible that Apple may ship USB cables that are reversible on both ends with upcoming mobile devices like the iPhone 6.
A8 iPhone 6 processor will reportedly have 1GB RAM
Alleged details of the next generation iPhone have emerged online today, its A8 processor may be accompanied by 1GB of RAM.
Motorola Droid Turbo crops up out of nowhere, S805 and QHD screen in tow
Yet another upcoming top-shelf Motorola smartphone seems to have surfaced online, carrying the ballsy Droid Turbo moniker and a Samsung Galaxy Note 4-rivaling spec sheet.
Premature Best Buy listing outs Moto 360 price and near-complete list of features
After gathering numerous bleak pricing hints in regards to the unveiled-but-not-yet-released Motorola Moto 360 smartwatch, it comes as a very nice last-minute surprise that the Android Wear timepiece is officially listed at a palatable $250.
5.5-inch 'iPhone 6L' tipped as 2,915 mAh battery beast, 4.7-inch iPhone 6 packs 1,810 mAh
With a little over three weeks reportedly left until Apple finally brings to light the greatly anticipated iPhone 6 pair, the battery capacity puzzle seems fully settled, although the latest purported leaks out of Asia, like all Asian leaks, have to be taken with prudence.
HTC One E8, aka plastic-made M8, en route to America's Sprint
HTC's fantastic in plastic, affordable, single rear camera-sporting take on the all-metal One M8, confusingly named One E8, is apparently headed stateside, after going live in a handful of European and Asian territories back in June.
Kateeva's coating makes bendable displays affordable
California-based Kateeva claims to have invented a flexible coating which can seal OLED displays. Their coating, which costs half the price of other alternatives, would allow for production of bendable screens at affordable prices.
Near-complete Samsung Galaxy Note 4 spec sheet surfaces, teasing also begins
You'd think Samsung would be in full damage control mode now that nearly everything there is to know about its upcoming Galaxy Note 4 is out, but even as a credible, semi-exhaustive list of features transpires, the Koreans insist on keeping mystery in the air.
First Asus smartwatch headed for market in September with Android Wear on board
Unlike Sony, which stubbornly wagers on a proprietary smartwatch OS, Asus reportedly plans to keep its wearable efforts simple and adopt the growing Android Wear platform.
Leaked Nokia Lumia 830 photos showcase PureView cam, various color options
Expected out in the days leading up to IFA 2014, at a press event recently teased by Microsoft, the Nokia Lumia 830 is a visual mystery no more, at least if we assume the newest slate of "leaked" photos is legitimate.
New discovery could change how we stop asteroids
Researchers have discovered that a rapidly spinning asteroid is actually a pile of rubble held together by Van der Waals forces. This may change how we approach defending against asteroids in the future.
Starwood Hotels hire robot butlers
Starwood's Aloft Hotel in Cupertino is doing a trial with two robots, which will bring amenities to guests and more. Starwood hopes to bring robots to more than 100 of their hotels in the near future.


text:
If you're looking for a web link or information that aired on Eyewitness News, this is where that information is posted.
Deramaxx 11/13/2006
USA Today Article of Safety of Pet Medication 11/13/2006
Free Prescription Drugs from Meijer 10/23/2006
Stage Fright 10/23/2006Check out the haunted houses at Stage Fright Indy.
Pray For Emily 10/10/2006MySpace page for Emily Downey
Circle City Classic 10/05/2006Check out all the events related to the Circle City Classic this weekend.
IN District 41: Greg Walker 10/03/2006Republican Greg Walker, 42, is an accountant from Columbus, IN. He defeated incumbant Bob Garton in the May GOP Primary.
IN District 41: Terry Coriden 10/03/2006Democrat Terry Coriden, 59, is an attorney from Columbus, IN. He's a former city attorney for Columbus.
IN District 41: Kenn Gividen 10/03/2006Libertarian Kenn Gividen, 53, is a direct marketer from Columbus, IN. He ran for the State Senate in 2002 and Governor in 2004.
Bret Neylon Updates 09/29/2006Welcome to the new Morris Trucking/Team Bloomington web site
08/14/2006Dell Inc. said Monday it will recall 4.1 million notebook computer batteries made by Sony Corp. because they can overheat and catch fire.
08/15/2006Men's Magazine 100 most angry cities
Tips to Save Energy 07/14/2006
Tips to Stay Cool 07/14/2006
American Cancer Society 07/05/2006
Indianapolis Downtown Inc 07/05/2006This web site has information on Black Expo, traffic restrictions, road closings,parking, hotels and other information.
Sports of All Sorts 06/28/2006
Taking Down Words 06/22/2006Link to a Democrat blog site with the entire Hoosier Lottery Complaint
Indy Aquatics 06/14/06Pool info for the City of Indianapolis.
One Sole - 06/14/06Shoes with interchangeable tops.
Colts: Make It Personal 06/14/2006Visit the Colts: Make It Personal Tour bus over the next few weeks. It's traveling around the state. Here's a list of it's stops - and what you'll find inside the bus.
Cool Touch 06/13/06New treatment for varicose veins.
Microsoft Security 06/13/2006Download the latest security patches from Microsoft.
FBI report on violent crime 06/12/06The FBI released the Preliminary Annual Uniform Crime Report for 2005 Monday, which showed a mixed direction in crime nationwide: the number of violent crime offenses rose 2.5 percent, but the number of property crime offenses decreased 1.6 percent when compared with data from 2004.
HIV/AIDS Prevention 06/11/2006
Keeping kids safe online - 06/09/06This page from Missingkids.com has many resources for parents and teens to stay safe online.
Lucas Oil Stadium - scale model 06/08/06See a scale model of the new Lucas Oil Stadium.
Sun Pill 06/07/06Can a pill really help protect you from the sun's harmful rays? One company says yes.
Helping America's Youth 06/06/06Learn more about a youth mentoring program supported by the President and First Lady.
Hewlett-Packard - 06/06/06This update from HP prevents certain types of digital cameras from applying a charge to the batteries which can cause them to overheat.
Home-A-Rama 06/6/06The Home-A-Rama opens its doors to nine luxurious homes in the exclusive Sagamore community in Noblesville. The tours begin on Saturday, June 10th.
Probable cause affidavit
Congressional travel 06/05/06The following links track the travel habits of your congressional representatives:American Radio WorksPublic IntegrityMedill News - Power Trips
Laura VanRyn 06/01/2006Family blog of the Laura VanRyn family which chronicles the recovery of the girl they thought was their daughter.
Bruce Kopp "Little Red Door Open" 05/31/06Register now for the 2nd Annual Bruce Kopp "Little Red Door Open" on Thursday, June 22nd at 12:00 noon at Prestwick Country Club in Avon, IN. Proceeds benefit the Little Red Door Cancer Agency which assists medically underserved residents of Central Indiana.
Bean Blossom Bluegrass Festival 05/31/06The Bean Blossom Bluegrass Festival is June 10-17 at the Bill Monroe Music Park.
38th Street detour info 05/29/06Plan your route while 38th Street is closed between Michigan and I-65.
Indy Aquatics 05/29/06Pool info for the City of Indianapolis.
Jeffrey Mittman 05/29/06Army Sergeant Jeffrey Mittman suffered serious injuries in Iraq on July 7, 2005. He faces a series of surgeries to repair the injuries before he resumes his life in New Palestine. He has received numerous notes of thanks and encouragement from all over the country. If you would like to add your own, you may follow this link to Jeff Mittman's e-mail account.
Cara Charities 05/25/06One of the most popular social events surrounding the Indianapolis 500-Mile Race celebrates its 25th anniversary in 2006.
Allstate best drivers list 05/25/06Find out how your city or town ranks.
Indy Jazz Fest 05/23/2006The Indy Jazz Fest is at Military Park June 16-18. Herbie Hancock and Bonnie Raitt are among the performers. For a complete schedule and ticket information - here's a link to the festival's website.
The US Government's Official web portal 05/22/2006Link to Veterans Affairs website for info about veterans' vital information being stolen.
US Veterans ID Theft 05/22/06Check this site if you have concerns about a report that veterans' Social Security numbers were taken home by a government employee.
Megabus 05/22/06For cheap bus tickets to Chicago and other Midwest destinations.
Buckle Up America 05/22/06Get information on seat belt safety.
Indiana Department of Education 05/19/06See Adequate Yearly Progress reports for Hoosier students.
French Lick Resort 05/18/06Get an update on the restoration.
Children's Bureau 05/18/06
Major Moves 05/18/06Read about the state's ten-year road-building plan.
Cody's First Step 05/16/06Learn more about Cody Unser's fundraising efforts for transverse myelitis.
Internet safety tips for parents 05/16/06Advice for parents and teens online 05/16/06Online safety advice from the National Center for Missing and Exploited Children 05/16/06Monitoring software reviews 05/16/06
Adventure Playset recall 05/16/06Get a list of backyard playsets involved in a recall. The affected playsets have defective bolts that could cause the swingset frame to detach.
Creative Patriot 05/16/05Follow the journey of painter Scott Lobaido. He's a New York City man traveling to all 50 states to paint a flag on a building rooftop. It's a tribute to the military troops returning home from the war. He'll be in Indianapolis in June.
Visit Indiana Card 05/15/2006Find out how to get discounts on in-state tourist destinations. You can get a card free at any Kroger store. Kroger locations.
Indiana Surplus Sale 05/15/2006The state is selling real estate, aircraft & homes to get rid of assets Indiana no longer needs. This will link you to a list of what is up for auction.
Heart to Heart 05/12/2006Myesha Morris book signing Saturday, May 13th from 2-4:30 p.m. at Universal Ministries Worldwide Assembly 1927 E. 32nd Street, Indianapolis.
The book is available at the Borders in Castleton and the Family Christian Bookstore in Speedway. You may order a copy of Heart to Heart $14.95 plus tax at: firstname.lastname@example.com
If you are interested in hiring Myesha through supported employment please contact Noble of Indiana, 375-4256 or email: email@example.com
Indiana Dept of Natural Resources-Indianapolis Star "Falcon Cam" 05/12/2006The Indiana Dept of Natural Resources and our partners at The Indianapolis Star cooperated to bring you a web page featuring a live camera at a peregrine falcon's nest in downtown Indianapolis. IndyStar.com thanks the Indiana Department of Natural Resources, Mansur Property Management, and Xila Communications for their support and cooperation in making Falcon Cam possible.
PLUS inmate reform program 05/11/2006Learn more about a program that seeks to turn inmates' lives around through faith and character building.
Military Mother's Day Greetings 05/11/2006View video clips of military greetings from Hoosier soldiers to their moms.
Medicare Prescription Drug Benefit 05/11/2006Get information on the different plans available.
Flex fuel cars 05/10/2006Is your car on the E85 list ?
Executive Service Corps 05/10/2006This is the home page of Executive Service Corps of Indiana and its mentoring program for high school students.
Discover Mass. Ave 05/10/2006Find out about events in this popular cultural district near downtown Indianapolis.
WHO Avian Flu 05/09/2006Track cases of avian flu throughout the world. See also Indiana's plan for a flu pandemic .
50 Smart Places to Live 05/09/2006Find out if your community made the list!
500 Festival Mini Marathon Results 05/08/2006
Indianapolis Motor Speedway Schedule 05/07/2006
I-SAFE: Internet Safety Education 05/05/2006Internet Safety Education
NetSmartz 05/05/2006Internet Policing for Parents and Guardians
Best Indiana companies to work for 05/03/2006These are the best Indiana companies to work for, as selected by the Indiana Chamber of Commerce. Find out if your employer made the list!
Pandemic Flu 05/03/2006The federal government's plan for a flu pandemic.
Mini Marathon 05/02/2006For more information on the Mini-Marathon
Chase Bank 05/01/2006Report a fraudulent email to Chase.
Sunlight Foundation 04/28/06
Open Secrets 04/28/06
Track where money to politicians is coming from.
PLUS inmate reform program 04/28/06Learn more about a program that seeks to turn inmates' lives around through faith and character building.
Edmunds 04/28/06This is an automotive research website that recently did a gas savings test on two vehicles. See the results!
Visian Implantable Lens 04/26/06A new way to see without glasses. See also: FDA approval of Visian lens and Staar Surgical
Beech Grove redevelopment 04/25/2006Redevelopment plan for the City of Beech Grove
Gas Buddy 04/25/2006Find the lowest gas prices in your city. Information is updated several times a day.
Indiana Voter ID 04/24/2006You will need to have a photo ID with you when you vote during the May 2 primary
Carmel-Clay comprehensive land use plan 04/19/2006People who live in Carmel's Clay Township can weigh in on the latest draft of the community's comprehensive plan. Residents can hear about the plan and ask questions at an open house 8 a.m. to 2 p.m. Saturday May 6th at Carmel City Hall.
Energy Conservation Tips 04/19/2006Get ideas on how to save energy. For more ideas locally, visit Earth Day Indiana - This takes place on April 22, 2006
Summer Concert Schedule 04/18/2006Verizon Wireless Music Center releases full concert schedule for 2006
Dents & Dings Repair 04/17/2006Information about repairing dents and dings to your vehicles from hail damage.
Indiana Stadium construction cameras
Help Is Here Express 04/13/2006Prescription Drug Program Assistance
Organ Donation Website 04/12/2006Learn more about the how organ donors are finding patients who need their help. It is illegal to receive any kind of financial benefit from organ donation.
Apple Computer Windows Software 04/06/2006Look on the Apple website for a free download to get Windows software.
American Cancer Society 04/04/2006Relay for Life is a fun-filled overnight event to raise money for research and programs for the American Cancer Society. Teams camp out for 24 hours, taking turns to walk and run the track.
Best Indiana Places 04/03/2006View the list of 100 best places to live in the United States according to Relocate-America. The list includes four Indiana cities.
Salvation Army in Indiana 04/03/2006Find out how to help storm victims through the local chapter of the Salvation Army
Indianapolis International Airport Parking 03/31/2006Reserve your spot in the Tiger Lot.
Indy Jazz Fest 03/30/2006The festival is a three-day musical celebration spotlighting the best in jazz, funk, R&B, blues, zydeco, gospel and more. We have local, regional and national appeal and are a family-oriented music festival.
Apple iPod Volume Control Update 03/29/2006Apple has released a free software download that will allow you to set a maximum volume limit on some iPods.
Kelvin Sampson Website and Biography 03/28/2006For more information about Kelvin Sampson.. who resigned as Oklahoma's basketball coach. Sources say he'll take the head coaching job at Indiana.. replacing Mike Davis.
Indiana Chamber of Commerce 03/28/2006Link to Chamber of Commerce web site with tips on how to deal with Indiana's changing of the clocks on April 2.
The Federal Reserve for Kids 03/28/2006Information on the Fed's history and operations is all offered in a kid friendly way. The goal is to bolster financial literacy in a new generation.
Forbes.com 03/27/2006Ten Cars With The Best Residual Values
Financial Literacy 03/25/2006Easy things workers can do to save money on taxes.
Indianapolis Airport flight information
Indiana Do Not Call list

subset: commoncrawl


text:
Another great show. Just recorded an episode earlier tonight.
Another great show. Just recorded an episode earlier tonight.
I ****ing love Bourdain. His takes are all right on (except he took it a bit easy on RayRay). I especially liked blurbs on Giada and Mario. Molto Mario was the best!
I'll agree some of the stuff he makes is insanely complicated, but it is all authentic and traditional. I'm actually glad he doesnt take the easy road when it comes to Mexican food because so much of it is so complex.
I cant believe no one has thrown Robin Miller under the bus yet, but i guess thats because no one is watching her show
The most annoying is that Giada isn't topless...nuff said.
I love Rachel Ray. Her mouth was built for blowjobs.
Cookin in Brooklyn is with Alan Harding on the Discovery Home channel. He rocks. And his recipes... well, he just kinda dumps a ****load of stuff in... hilarious.Quote:
What is that?
But again off-network, I love Andrea Immer (her wine-pairing cookbook of original recipes absolutely ROCKS) and America's Test Kitchen kicks MAJOR ass. Now THAT is a great show. The recipes are almost always foolproof, and the product testing is great. No celeb bull**** there. It hasn't changed one iota in well over 10 years.
And for you Tony Bourdain fans, if you haven't read his guest blog rant on foodTV chefs, check it out HERE. It's HILARIOUS. He's done other guest blogs there recently too.
Totally agree on Immer. She's great, and very impressive. She is a trained chef, as well as being one of only 14 women in the world who are master sommeliers. Plus, she reminds me of my aunt. ;)
Ray, hands down! Can't stand that b****!
Yum-Oh! Shut the F*** up!
I voted Bobby Flay solely because of his antics after he won the Iron Chef competition (the Japanese one). But, how the hell can you leave the Barefoot Contessa off this list? Dear God, I just cannot stand her and her douchebag housband. If I were as rich as her husband obviously is and my wife did nothing but sit at home so that she can cook and get fatter I'd be kind of pissed.
Yeah honey, I really do love how you went down the the cheese shop and bought that fresh fetta to crumble over the freshly chopped vegetables from our garden but can you do me a favor and jump on the ellypical machine a bit more often. It would be nice if one of these days you weren't TWICE MY SIZE!!!
Rachel Rae hands down. It's her voice. Good lord, shut her up sometimes.


text:
Did the success of Snooki on the MTV reality show Jersey Shore help inspire the producers of The Bachelorette cast Emily Maynard as their new #1 most eligible single? People magazine thinks her casting is official. While Snooki professes to be a Jersey Girl with loose Catholic morals, Emily [who recently broke off her engagement with The Bachelor Brad Womack after his second go-around with the show] purports to be an All-American girl. Conservative, Southern Baptist, and very well kept, she's the polar opposite from Nicole Polizzi but queen in her own small corner of the world.
The Bachelorette 2012: What to expect if they cast Emily Maynard
Here's just a few things people who love to watch The Bachelorette can look forward to in the upcoming season if rumor mill reports are true that Emily Maynard has already been cast as the next most eligible single focus of the show. What do they both have in common? That's a pretty simple question to answer. Each one thinks their half of the United States revolves around them like they are the sun and their fans are their devoted servants from around the world. More over, both seem to be completely enamored with high hopes of becoming even more rich and famous than they already are by airing their idiosyncrasies and dirty laundry on a reality television show.
- Ricki, Ricki, Ricki. EmilyMaynard is obsessed with herself, her home life, and her 6-year-old daughter Ricki. Named after her dead father, young Ricki is quite the spoiled girl. Her suddenly famous mom talks about being a celebrity parent as often as Snooki mentions liquor, flashes her cootchie coo at the club while out dancing, and denies she has a secret romance going on the side with Mike 'The Situation' Sorrentino. Neither woman ever starts a conversation that's more interesting or participates in one that's more in-depth. It's like they are emotionally stunted and have never read a book about anything insightful. The only thing they are able to discuss is themselves despite all that is happening in this big, beautiful world.
- There's no place like home. Snooki might love spending time at the Jersey Shore, but you can bet your last dollar that if she met a hot guy from another cool city, he was rich, and totally in love with her she'd move and make him marry her. Not Emily Maynard. Word is the only way the producers could land a contract with her was if they agreed to move their Hollywood production to her hometown of Charlotte, N.C. What's more, Emily already refused to move to Texas to live with or marry her fiance Brad Womack — so any gentlemen suitors need to be prepared to kiss their careers and life goodbye. Oh, and PS — they will have to rent of buy a place in North Kakolacki if they expect to date her because nobody's allowed to shack up with her and her little girl.
- The past trumps the present. When Emily Maynard lost her fiance, she lost more than a hand to hold. Used to living the glamorous lifestyle of a trophy girl, her NASCAR driver boyfriend Ricky Hendrick and his wealthy family gave her a taste of the life of luxury while the two were still teens. He died at age 19, impressing forever on the little blonde the romantic ideals of a high school love affair mixed with having access to every material think in the world one could possible ever want. According to Maynard, she found out days after he was killed that she was pregnant with his baby. That grandchild has kept her linked financially to her dead boyfriend's family — and to make sure they never forgot it, she named they child after him (even though she was a girl). That little trump card plays on an emotional heart string more often than Snooki does shots at Karma whenever she's in town.
- Then there is Brad Womack (yep — he is still hanging around). Even though Brad Womack totally blew it with Chantal O, the daughter of the Seattle Seahawks owner who was his perfect match and the best girl around, he is still sniffing around Maynard after his last V2 season of The Bachelor. While we suspect he is hoping the third time he might appear as the central feature of a show, our suspicions have yet to be confirmed. But, always making sure she has the men of the world fawning over her as the most likeable and sweet, helpless Barbie doll looking girl, Emily says she and bad Brad are still really close. Nothing like a hot right guy who is totally built and has a huge back tattoo of a giant cross to keep the interest of a good Southern girl. Maynard claims Womack "taught me that I have it in me to love again." Uh-huh… in a bunch of new positions that never made it into the Karma Sutra either, we're sure. It makes one wonder if they practiced the Jersey Shore pull the dirty comforter over themselves to avoid being filmed while fooling around or being caught in the act by the little girl.
So heading towards the Summer of 2012 with eager anticipation to find out if Emily Maynard is the new Bachelorette (for better or for worse), we all have to resist the urge to vomit in our mouths a little when saying that since Ricky's death, Ricki's celebrity mom has made a living working as a charity benefit party planner. Yes… rumor is she hosts lavish events for charity benefits where her dead baby-daddy's family is in charge of contributing most.
And, guys thinking of courting her be warned… her entire mansion is decorated in shades of pink and green. The furniture, the walls, the floors, the ceiling, the carpets, and everything. She makes Lilly Pulitzer look like clothing made for Snooki and JWoww to wear while hooking. And while the curtains do not match her royal blond rug (metaphorically speaking), they do in fact match everything else. God forbid you have a window that is not decorated with expensive and embellished fabric that does not completely harmonize with everything. It's like looking at the playbook for building the Barbie Dream House — minus the hip factor and replacing the missing cool with Preppy Handbook meets old money bling the way it is set up.
To that end, our deepest condolences go out to whatever men do try to woo her. That girl is a self-absorbed and high-maintenance individual. While she probably thinks she means well by doing the charity work, she's not exactly doing a lot of unpaid labor for humanitarian causes… and no single woman without financial and physical help could possibly have the time of the financial resources to pay for the home the show filmed her living in with her daughter.
No way, no how Emily Maynard is a self-made multimillionaire who is more talented at decorating than Martha Stewart.
For that reason, if she has not been cast already — for the love of all that is decent and real — consider casting someone who really is a nice girl. Shawntel Newton is a hard-working woman with a profitable (albeit strange) career as a mortician. She's smart, funny, attractive, and most likely never meet a great guy without help because she lives in a small town and always works. Heck, she even got turned down by sustainable agriculture endorsing hipster Ben Flajnik — who appeared to think even he's too rich and famous to date her!
Emily Maynard, on the other hand, has been given all the best opportunities to have a successful life. She's totally able to pick and choose which men she wants to date and has them all lining up to do her bidding and be at her beck and call.
Granted, while people like Bentley Williams are the kind of guy most attracted to that type of girl, it will take a real man to man up and date sweet and sexy Shawntel.
To that end, do the world a favor and let her host her own show. After all, she's really good at getting money from people to help she and her daughter live a more glamorous lifestyle. Let The Bachelorette show be the place where everyday nice guys are able to compete to win the heart of a genuinely loving and potentially long-term life mate sort of girl.
The high maintenance required for suitors to impress Emily is likely to bring the show record high ratings, but still. When the Jersey Shore cast Snooki it was for comic relief — not to be treated like she is the epicenter of the dating world. [And no, please don't case Nicole Polizzi to get your ratings back after that flop with Ashley Hebert either.]
But that's just my "one guy's take" on it all (and her) after being sucked into watching these shows with my girlfriend. At the very least I don't think I totally wasted my down time because now I have something foolish to gossip about when I am wasting time around the office water cooler at work. And for the record I mean it when I say I truly hope my gut instincts and impression that Emily Maynard is truly vain, manipulative, shallow, and a bit evil are wrong.
What's your take on Emily Maynard? Is she really the right person to cast on the show and truly a nice girl?


text:
Skip to content. |
Skip to navigation
Did you not find what you were looking for? Try the
Advanced Search
to refine your search.
Subscribe to an always-updated RSS feed.
Monsanto's genetically modified Roundup Ready
alfalfa may take over the West, as the company re-engineers the
world to conform to its business plan
The West in your Inbox


text:
Routes Sorted
L to R R to L Alpha
Kathy's Crack is a left-angling crack to the left of Stone Groove. The route follows a the crack which is filled with grass and shrubs before finishing on typical 11-Mile bathtubs. Best bet is to climb the crack and then bathtubs until reaching an easy traverse to the left ending in the descent gully. Note: Would be a decent beginner lead if it was cleaned. I climbed this route with a 70m rope but a 60 should reach if you traverse left 20-30 feet after the crack ends and bathtubs begin. With a 50m one should find a good spot toward the end of the crack to build a belay.
From the base of 11 Mile Dome, hike south 75 feet and then up the gully 150 feet. Kathy's Crack is the definable crack system left of Stone Groove which is an obvious, right-facing, wide crack. Currently, it's full of grass and shrubs.
A few small to medium cams.


text:
Earth day is April 22nd, and the Detroit Zoo is celebrating with its inaugural GreenFest.
The weekend will feature Earth-friendly craft projects, an endangered species and green scavenger hunt. GreenFest fun will also include a Green Games Gallery and hands-on science experiments. All activities are free with Zoo admission.
GreenFest runs Saturday, April 20th and Sunday April 21st from 9:00 a.m. until 3:00 p.m..
Click here for more information.
35 Skyline Drive
Phone: (407) 644-3535
Didn't find what you were looking for?
All content © Copyright 2000 - 2014 Fox Television Stations, Inc. and Worldnow. All Rights Reserved.
Privacy Policy | New Terms of Service What's new | Ad Choices


text:
Outdoor Leadership Ministries
Cool Facts
Did you know that Outdoor Leadership Ministries majors get to:
- Participate in wilderness dogsled and ski treks.
- Practice living outdoors in winter and summer conditions.
- Learn how to construct snow shelters.
- Analyze and interpret American youth culture for the purpose of understanding and ministering to adolescents.
- Gain an understanding of backpacking equipment, trip planning, camping skills, group management and backpacking trips.
- Learn how to conduct beginning top rope rock climbing experiences in camps, adventure programs and other wilderness settings.
- Gain essential skills in nurturing spiritual development in children.
- Practice providing emergency medical care in remote areas by using portable and improvised equipment.


text:
Insulin-like growth factor 1
Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene.[1][2] IGF-1 has also been referred to as a "sulfation factor"[3] and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s.
IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin, is used for the treatment of growth failure.[4]
IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7,649 daltons.[5]
- 1 Synthesis and circulation
- 2 Mechanism of action
- 3 Receptors
- 4 Related growth factors
- 5 Factors influencing the levels in the circulation
- 6 Clinical significance
- 7 Diagnostic test
- 8 As a therapeutic agent
- 9 Miscellaneous uses
- 10 Interactions
- 11 References
- 12 Further reading
- 13 External links
Synthesis and circulation[edit]
IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone (GH) and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signalling pathway post GH receptor including SHP2 and STAT5B. Approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio.
In rat experiments the amount of IGF-1 mRNA in the liver was positively associated with dietary casein and negatively associated with a protein-free diet.[6]
Recently, an efficient plant expression system was developed to produce biologically active recombinant human IGF-I (rhIGF-I) in transgenic rice grains.[7]
Mechanism of action[edit]
Its primary action is mediated by binding to its specific receptor, the insulin-like growth factor 1 receptor (IGF1R), which is present on many cell types in many tissues. Binding to the IGF1R, a receptor tyrosine kinase, initiates intracellular signaling; IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death .[citation needed]
IGF-1 is a primary mediator of the effects of growth hormone (GH). Growth hormone is made in the anterior pituitary gland, is released into the blood stream, and then stimulates the liver to produce IGF-1. IGF-1 then stimulates systemic body growth, and has growth-promoting effects on almost every cell in the body, especially skeletal muscle, cartilage, bone, liver, kidney, nerves, skin, hematopoietic cell, and lungs. In addition to the insulin-like effects, IGF-1 can also regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis.
Deficiency of either growth hormone or IGF-1 therefore results in diminished stature. GH-deficient children are given recombinant GH to increase their size. IGF-1 deficient humans, who are categorized as having Laron syndrome, or Laron's dwarfism, are treated with recombinant IGF-1. In beef cattle, circulating IGF-1 concentrations are related to reproductive performance.[8]
Insulin-like growth factor 1 receptor (IGF-1R) and other tyrosine kinase growth factor receptors signal through multiple pathways. A key pathway is regulated by phosphatidylinositol-3 kinase (PI3K) and its downstream partner, the mammalian target of rapamycin (mTOR). Rapamycins complex with FKBPP12 to inhibit the mTORC1 complex. mTORC2 remains unaffected and responds by upregulating Akt, driving signals through the inhibited mTORC1. Phosphorylation of eukaryotic initiation factor 4e (eif-4E) [4EBP] by mTOR inhibits the capacity of 4EBP to inhibit eif-4E and slow metabolism.
IGF-1 binds to at least two cell surface receptors: the IGF-1 receptor (IGF1R), and the insulin receptor. The IGF-1 receptor seems to be the "physiologic" receptor - it binds IGF-1 at significantly higher affinity than the IGF-1 that is bound to the insulin receptor. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. IGF-1 activates the insulin receptor at approximately 0.1 times the potency of insulin. Part of this signaling may be via IGF1R/Insulin Receptor heterodimers (the reason for the confusion is that binding studies show that IGF1 binds the insulin receptor 100-fold less well than insulin, yet that does not correlate with the actual potency of IGF1 in vivo at inducing phosphorylation of the insulin receptor, and hypoglycemia).
IGF-1 is produced throughout life. The highest rates of IGF-1 production occur during the pubertal growth spurt. The lowest levels occur in infancy and old age.
Other IGFBPs are inhibitory. For example, both IGFBP-2 and IGFBP-5 bind IGF-1 at a higher affinity than it binds its receptor. Therefore, increases in serum levels of these two IGFBPs result in a decrease in IGF-1 activity.
Related growth factors[edit]
IGF-1 is closely related to a second protein called "IGF-2". IGF-2 also binds the IGF-1 receptor. However, IGF-2 alone binds a receptor called the "IGF-2 receptor" (also called the mannose-6 phosphate receptor). The insulin-like growth factor-II receptor (IGF2R) lacks signal transduction capacity, and its main role is to act as a sink for IGF-2 and make less IGF-2 available for binding with IGF-1R. As the name "insulin-like growth factor 1" implies, IGF-1 is structurally related to insulin, and is even capable of binding the insulin receptor, albeit at lower affinity than insulin.
A splice variant of IGF-1 sharing an identical mature region, but with a different E domain is known as mechano-growth factor (MGF).[9]
Factors influencing the levels in the circulation[edit]
Protein intake increases IGF-1 levels in humans, independent of total calorie consumption.[10] Factors that are known to cause variation in the levels of growth hormone (GH) and IGF-1 in the circulation include: genetic make-up, the time of day, age, sex, exercise status, stress levels, nutrition level and body mass index (BMI), disease state, race, estrogen status and xenobiotic intake.[11] The later inclusion of xenobiotic intake as a factor influencing GH-IGF status highlights the fact that the GH-IGF axis is a potential target for certain endocrine disrupting chemicals - see also endocrine disruptor. In free-ranging animals, nutrition and predators may influences levels of IGF-1.
Fasting, including intermittent fasting, can reduce IGF-1 levels rapidly and dramatically.[12]
Clinical significance[edit]
Contribution to aging[edit]
It is now widely accepted that signaling through the insulin/IGF-1-like receptor pathway is a significant contributor to the biological aging process in many organisms. This avenue of research first achieved prominence with the work of Cynthia Kenyon, who showed that mutations in the daf-2 gene double the lifespan of the roundworm, C. elegans.[13] Daf-2 encodes the worm's unified insulin/IGF-1-like receptor. Despite the impact of IGF1-like on C. elegans longevity, direct application to mammalian aging is not as clear as mammals do not form dauer-like developmental stages.
Insulin/IGF-1-like signaling is conserved from worms to humans. In vitro experiments show that mutations that reduce insulin/IGF-1 signaling have been shown to decelerate the degenerative aging process and extend lifespan in a wide range of organisms, including Drosophila melanogaster, mice,[14] and possibly humans.[15][16][17][18] Reduced IGF-1 signaling is also thought to contribute to the "anti-aging" effects of Calorie restriction.[19]
Nevertheless, anabolic deficiency in men with chronic heart failure is prevalent and could have an associated detrimental impact on survival. Deficiency of anabolic hormones identifies groups with a higher mortality.[20][21]
Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occur in old age.[22]
Therapeutic administration with neurotrophic proteins (IGF I) is associated with potential reversal of degeneration of spinal cord motor neuron axons in certain peripheral neuropathies.[23]
Rare diseases characterized by inability to make or respond to IGF-1 produce a distinctive type of growth failure. One such disorder, termed Laron dwarfism does not respond at all to growth hormone treatment due to a lack of GH receptors. The FDA has grouped these diseases into a disorder called severe primary IGF deficiency. Patients with severe primary IGFD typically present with normal to high GH levels, height below -3 standard deviations (SD), and IGF-1 levels below -3SD. Severe primary IGFD includes patients with mutations in the GH receptor, post-receptor mutations or IGF mutations, as previously described. As a result, these patients cannot be expected to respond to GH treatment.
People with Laron syndrome have strikingly low rates of cancer and diabetes.[24]
The IGF signaling pathway has a pathogenic role in cancer. Studies have shown that decreased levels of IGF lead to decreased growth of existing cancer cells.[25] People with Laron syndrome have also recently been shown to be of much less risk to develop cancer.[26] Dietary interventions and modifications such as vegan diets shown to down regulate IGF-1 activity, has been associated with lower risk of cancer.[27]
Diagnostic test[edit]
IGF-1 levels can be measured in the blood in 10-1000 ng/ml amounts. As levels do not fluctuate greatly throughout the day for an individual person, IGF-1 is used by physicians as a screening test for growth hormone deficiency and excess in acromegaly and gigantism.
Interpretation of IGF-1 levels is complicated by the wide normal ranges, and marked variations by age, sex, and pubertal stage. Clinically significant conditions and changes may be masked by the wide normal ranges. Sequential management over time is often useful for the management of several types of pituitary disease, undernutrition, and growth problems.
As a therapeutic agent[edit]
Mecasermin (brand name Increlex) is a synthetic analog of IGF-1 which is approved for the treatment of growth failure.[28] IGF-1 has been manufactured recombinantly on a large scale using both yeast and E. coli.
Several companies have evaluated IGF-1 in clinical trials for a variety of additional indications, including type 1 diabetes, type 2 diabetes, amyotrophic lateral sclerosis (ALS aka "Lou Gehrig's Disease"),[29] severe burn injury and myotonic muscular dystrophy (MMD). Results of clinical trials evaluating the efficacy of IGF-1 in type 1 diabetes and type 2 diabetes showed great promise in reducing hemoglobin A1C levels, as well as daily insulin consumption. However, the sponsor, Genentech, discontinued the program due to an exacerbation of diabetic retinopathy[30] in patients coupled with a shift in corporate focus towards oncology. Cephalon and Chiron conducted two pivotal clinical studies of IGF-1 for ALS, and although one study demonstrated efficacy, the second was equivocal, and the product has never been approved by the FDA.
However, in the last few years, two additional companies, Tercica and Insmed, compiled enough clinical trial data to seek FDA approval in the United States. In August 2005, the FDA approved Tercica's IGF-1 drug, Increlex, as replacement therapy for severe primary IGF-1 deficiency based on clinical trial data from 71 patients. In December 2005, the FDA also approved Iplex, Insmed's IGF-1/IGFBP-3 complex. The Insmed drug is injected once a day versus the twice-a-day version that Tercica sells.
Insmed was found to infringe on patents licensed by Tercica, which then sought to get a U.S. district court judge to ban sales of Iplex.[31] To settle patent infringement charges and resolve all litigation between the two companies, in March 2007 Insmed agreed to withdraw Iplex from the U.S. market, leaving Tercica's Increlex as the sole version of IGF-1 available in the United States.[32]
By delivering Iplex in a complex, patients might get the same efficacy with regard to growth rates but experience fewer side effects with less severe hypoglycemia.[citation needed] This medication might emulate IGF-1's endogenous complexing, as in the human body 97–99% of IGF-1 is bound to one of six IGF binding proteins.[citation needed] IGFBP-3 is the most abundant of these binding proteins, accounting for approximately 80% of IGF-1 binding.
IGFBP-3 is a carrier for IGF-1, meaning that IGF-1 binds IGFBP-3, creating a complex whose combined molecular weight and binding affinity allows the growth factor to have an increased half-life in serum. Without binding to IGFBP-3, IGF-1 is cleared rapidly through the kidney, due to its low molecular weight. But when bound to IGFBP-3, IGF-1 evades renal clearance. Also, since IGFBP-3 has a lower affinity for IGF-1 than IGF-1 has for its receptor, IGFR, its binding does not interfere with IGF-1 function.
In a clinical trial of an investigational compound ibutamoren, which raises IGF-1 in patients, did not result in an improvement in patients' Alzheimer's symptoms.[33] Another clinical demonstrated that Cephalon's IGF-1 does not slow the progression of weakness in ALS patients, but other studies shown strong beneficial effects of IGF-I replacement therapy in ALS patients,[34] and therefore IGF-I may have the potential to be an effective and safe medicine against ALS,[35] however other studies had conflicting results.[36]
IGF-1 has also been shown to be effective in animal models of stroke when combined with erythropoietin. Both behavioural and cellular improvements were found.[37]
Miscellaneous uses[edit]
Numerous sources have claimed that Deer Antler Spray, purportedly extracted from cervid sources, contains IGF-1.[38][39][40][41] Credence to this claim comes from the fact that deer's antlers grow extremely rapidly and that the associated cellular factors can similarly aid in skeletal healing in humans. IGF-1 is currently banned by various sporting bodies. However, sprays and pills claiming to be 'deer antler velvet extracts' are freely available on the market.[42] As IGF-1 is a protein, it cannot be absorbed orally since it is rapidly broken down in the gastrointestinal tract.[43] In September, 2013, the headquarters of SWATS, an infamous distributor of deer antler spray and other controversial products, was raided and ordered to shut down by Alabama's attorney general citing "numerous serious and willful violations of Alabama's deceptive trade practices act".[44][45]
Anthony Bosch, of the Biogenesis clinic in Miami, Florida, alleged to have supplied and injected New York Yankee Alex Rodriguez with Insulin-like growth factor 1, along with several other performance enhancing drugs.[citation needed]
Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 Binding Proteins (IGFBPs), of which there are six (IGFBP1–6).
Specific references are provided for interactions with IGFBP3,[46][47][48][49][50][51] IGFBP4,[52][53] and IGFBP7.[54][55]
- ^ Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS (1985). "The human gene encoding insulin-like growth factor I is located on chromosome 12". Hum. Genet. 69 (2): 157–60. doi:10.1007/BF00293288. PMID 2982726.
- ^ Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL (1983). "Sequence of cDNA encoding human insulin-like growth factor I precursor". Nature 306 (5943): 609–11. doi:10.1038/306609a0. PMID 6358902.
- ^ Salmon W, Daughaday W (1957). "A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro". J Lab Clin Med 49 (6): 825–36. PMID 13429201.
- ^ Keating GM (2008). "Mecasermin". BioDrugs 22 (3): 177–88. doi:10.2165/00063030-200822030-00004. PMID 18481900.
- ^ Rinderknecht E, Humbel RE (1978). "The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin". J Biol Chem 253 (8): 2769–2776. PMID 632300.
- ^ Miura Y, Kato H, Noguchi T (March 1992). "Effect of dietary proteins on insulin-like growth factor-1 (IGF-1) messenger ribonucleic acid content in rat liver". Br. J. Nutr. 67 (2): 257–65. doi:10.1079/BJN19920029. PMID 1596498.
- ^ Cheung SC, Liu LZ, Lan LL, Liu QQ, Sun SS, Chan JC, Tong PC (2011). "Glucose lowering effect of transgenic human insulin-like growth factor-I from rice: in vitro and in vivo studies". BMC Biotechnol. 11: 37. doi:10.1186/1472-6750-11-37. PMC 3098155. PMID 21486461.
- ^ Yilmaz A, Davis ME, RCM Simmen RCM (1999). "Reproductive performance of bulls divergently selected on the basis of blood serum insulin-like growth factor I concentration". J Anim Sci 77 (4): 835–9. PMID 10328346.
- ^ Carpenter V, Matthews K, Devlin G, Stuart S, Jensen J, Conaglen J, Jeanplong F, Goldspink P, Yang SY, Goldspink G, Bass J, McMahon C (February 2008). "Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction". Heart Lung Circ 17 (1): 33–9. doi:10.1016/j.hlc.2007.04.013. PMID 17581790.
- ^ McGlothin P, Averill M (2008). The CR way: using the secrets of calorie restriction for a longer, healthier life (1st ed.). New York: Collins. p. 16. ISBN 978-0-06-137098-4. "Many studies of growth regulation in adulst and children show that protein intake increases IGF-1 levels - independent of calories"
- ^ Scarth J (2006). "Modulation of the growth hormone-insulin-like growth factor (GH-IGF) axis by pharmaceutical, nutraceutical and environmental xenobiotics: an emerging role for xenobiotic-metabolizing enzymes and the transcription factors regulating their expression. A review". Xenobiotica 36 (2–3): 119–218. doi:10.1080/00498250600621627. PMID 16702112.
- ^ "The power of intermittent fasting". BBC News. Retrieved 2 May 2013.
- ^ See publications documenting series of experiments at Cynthia Kenyon lab, in particular, Dorman JB, Albinder B, Shroyer T, Kenyon C (December 1995). "The Age-1 and Daf-2 Genes Function in a Common Pathway to Control the Lifespan of Caenorhabditis Elegans". Genetics 141 (4): 1399–406. PMC 1206875. PMID 8601482.; and Apfeld J, Kenyon C (October 1998). "Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span". Cell 95 (2): 199–210. doi:10.1016/S0092-8674(00)81751-1. PMID 9790527.
- ^ Bartke A (January 2011). "Single-gene mutations and healthy ageing in mammals". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 366 (1561): 28–34. doi:10.1098/rstb.2010.0281. PMC 3001310. PMID 21115527.
- ^ Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD (February 2011). "Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans". Sci Transl Med 3 (70): 70ra13. doi:10.1126/scitranslmed.3001845. PMC 3357623. PMID 21325617.
- ^ Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, Chen J, Joyner AH, Schork NJ, Hsueh WC, Reiner AP, Psaty BM, Atzmon G, Barzilai N, Cummings SR, Browner WS, Kwok PY, Ziv E (August 2009). "Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity". Aging Cell 8 (4): 460–72. doi:10.1111/j.1474-9726.2009.00493.x. PMC 3652804. PMID 19489743.
- ^ Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P (March 2008). "Functionally significant insulin-like growth factor I receptor mutations in centenarians". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3438–42. doi:10.1073/pnas.0705467105. PMC 2265137. PMID 18316725.
- ^ van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW, Zwaan BJ, Slagboom PE, Westendorp RG (April 2005). "Reduced insulin/IGF-1 signalling and human longevity". Aging Cell 4 (2): 79–85. doi:10.1111/j.1474-9728.2005.00148.x. PMID 15771611.
- ^ Barzilai N, Bartke A (February 2009). "Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones". J. Gerontol. A Biol. Sci. Med. Sci. 64 (2): 187–91. doi:10.1093/gerona/gln061. PMC 2655014. PMID 19228789.
- ^ Friedrich N, Schneider HJ, Haring R, Nauck M, Völzke H, Kroemer HK, Dörr M, Klotsche J, Jung-Sievers C, Pittrow D, Lehnert H, März W, Pieper L, Wittchen HU, Wallaschofski H, Stalla GK (January 2012). "Improved prediction of all-cause mortality by a combination of serum total testosterone and insulin-like growth factor I in adult men". Steroids 77 (1–2): 52–8. doi:10.1016/j.steroids.2011.10.005. PMID 22037276.
- ^ Jankowska EA, Biel B, Majda J, Szklarska A, Lopuszanska M, Medras M, Anker SD, Banasiak W, Poole-Wilson PA, Ponikowski P (October 2006). "Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival". Circulation 114 (17): 1829–37. doi:10.1161/CIRCULATIONAHA.106.649426. PMID 17030678.
- ^ Sattler FR (August 2013). "Growth hormone in the aging male". Best Pract. Res. Clin. Endocrinol. Metab. 27 (4): 541–55. doi:10.1016/j.beem.2013.05.003. PMID 24054930.
- ^ Insulin-like growth factor-I: potential for treatment of motor neuronal disorders. Lewis ME, Neff NT, Contreras PC, Stong DB, Oppenheim RW, Grebow PE, Vaught JL.SourceCephalon, Inc., West Chester, Pennsylvania 19380!
- ^ Wade N (2011-02-17). "Ecuadorean Villagers May Hold Secret to Longevity". New York Times.
- ^ Arnaldez FI, Helman LJ (June 2012). "Targeting the insulin growth factor receptor 1". Hematol. Oncol. Clin. North Am. 26 (3): 527–42, vii–viii. doi:10.1016/j.hoc.2012.01.004. PMC 3334849. PMID 22520978.
- ^ Gallagher EJ, LeRoith D (April 2011). "Is growth hormone resistance/IGF-1 reduction good for you?". Cell Metab. 13 (4): 355–6. doi:10.1016/j.cmet.2011.03.003. PMID 21459318.
- ^ McCarty, M. F. "Vegan proteins may reduce risk of cancer, obesity, and cardiovascular disease by promoting increased glucagon activity." Medical hypotheses 53.6 (1999): 459-485.
- ^ Rosenbloom AL (August 2007). "The role of recombinant insulin-like growth factor I in the treatment of the short child". Curr. Opin. Pediatr. 19 (4): 458–64. doi:10.1097/MOP.0b013e3282094126. PMID 17630612.
- ^ Vaught JL, Contreras PC, Glicksman MA, Neff NT (1996). "Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease". Ciba Found. Symp. 196: 18–27; discussion 27–38. PMID 8866126.
- ^ "Genentech Discontinues IGF-I Drug Development Effort in Diabetes" (Press release). Genentech. 5 September 1997. Retrieved 15 March 2013.
- ^ Pollack A (2007-02-17). "Growth Drug Is Caught Up in Patent Fight". The New York Times. Retrieved 2010-03-28.
- ^ Pollack A. (2007-03-07). "To Settle Suit, Maker Agrees to Withdraw Growth Drug". The New York Times. Retrieved 2010-03-28.
- ^ Sevigny JJ, Ryan JM, van Dyck CH, Peng Y, Lines CR, Nessly ML (November 2008). "Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial". Neurology 71 (21): 1702–8. doi:10.1212/01.wnl.0000335163.88054.e7. PMID 19015485.
- ^ Nagano I, Shiote M, Murakami T, Kamada H, Hamakawa Y, Matsubara E, Yokoyama M, Moritaz K, Shoji M, Abe K (October 2005). "Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis". Neurol. Res. 27 (7): 768–72. doi:10.1179/016164105X39860. PMID 16197815.
- ^ Sakowski SA, Schuyler AD, Feldman EL (April 2009). "Insulin-like growth factor-I for the treatment of amyotrophic lateral sclerosis". Amyotroph Lateral Scler 10 (2): 63–73. doi:10.1080/17482960802160370. PMC 3211070. PMID 18608100.
- ^ Sorenson EJ, Windbank AJ, Mandrekar JN, Bamlet WR, Appel SH, Armon C, Barkhaus PE, Bosch P, Boylan K, David WS, Feldman E, Glass J, Gutmann L, Katz J, King W, Luciano CA, McCluskey LF, Nash S, Newman DS, Pascuzzi RM, Pioro E, Sams LJ, Scelsa S, Simpson EP, Subramony SH, Tiryaki E, Thornton CA (November 2008). "Subcutaneous IGF-1 is not beneficial in 2-year ALS trial". Neurology 71 (22): 1770–5. doi:10.1212/01.wnl.0000335970.78664.36. PMC 2617770. PMID 19029516. Lay summary – newswise.com.
- ^ Fletcher L, Kohli S, Sprague SM, Scranton RA, Lipton SA, Parra A, Jimenez DF, Digicaylioglu M (July 2009). "Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke. Laboratory investigation". J. Neurosurg. 111 (1): 164–70. doi:10.3171/2009.2.JNS081199. PMID 19284235.
- ^ Jaslow R (2013-01-30). "Deer-antler spray: What is IGF-1?". CBS News.
- ^ Rovell D (2011-08-09). "Deer Antler Velvet Sales On The Rise, Does It Really Work?". CNBC.com
- ^ Spector D (05-15-13). "Deer Antler Spray: The Natural Supplement That Seems Too Good To Be True". BusinessInsider.com.
- ^ Kotz D. (2013-01-31). "Are deer antler spray and other muscle-boosting supplements safe?". Boston Globe
- ^ Hinnen J (2013-01-30). "S.W.A.T.S. salesman says he watched Tide players use deer spray". CBSSports.com.
- ^ Amet N, ChenX , Lee H-F, Zaro J, and Shen W-C (2010). "Transferrin Receptor–Mediated Transcytosis in Intestinal Epithelial Cells for Gastrointestinal Absorption of Protein Drugs". In Narang AS, Mahato RM. Targeted Delivery of Small and Macromolecular Drugs. Boca Ratan, Florida: CRC Press/Taylor & Francis Group. p. 32. ISBN 142008772X.
- ^ Galloway D (2013-09-05). "Sports Performance Company Ordered to Stop Selling 'Deer Antler Spray,' Other Products". WHNT.
- ^ Otano J (2013-09-05). "Ray Lewis' alleged deer antler supplier has office raided in Alabama". SI.com.
- ^ Horton JK, Thimmaiah KN, Houghton JA, Horowitz ME, Houghton PJ (June 1989). "Modulation by verapamil of vincristine pharmacokinetics and toxicity in mice bearing human tumor xenografts". Biochem. Pharmacol. 38 (11): 1727–36. doi:10.1016/0006-2952(89)90405-X. PMID 2735930.
- ^ Ueki I, Ooi GT, Tremblay ML, Hurst KR, Bach LA, Boisclair YR (June 2000). "Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system". Proc. Natl. Acad. Sci. U.S.A. 97 (12): 6868–73. doi:10.1073/pnas.120172697. PMC 18767. PMID 10823924.
- ^ Buckway CK, Wilson EM, Ahlsén M, Bang P, Oh Y, Rosenfeld RG (October 2001). "Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF binding". J. Clin. Endocrinol. Metab. 86 (10): 4943–50. doi:10.1210/jcem.86.10.7936. PMID 11600567.
- ^ Cohen P, Graves HC, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG (October 1992). "Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma". J. Clin. Endocrinol. Metab. 75 (4): 1046–53. doi:10.1210/jcem.75.4.1383255. PMID 1383255.
- ^ Twigg SM, Baxter RC (March 1998). "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit". J. Biol. Chem. 273 (11): 6074–9. doi:10.1074/jbc.273.11.6074. PMID 9497324.
- ^ Firth SM, Ganeshprasad U, Baxter RC (January 1998). "Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3". J. Biol. Chem. 273 (5): 2631–8. doi:10.1074/jbc.273.5.2631. PMID 9446566.
- ^ Bach LA, Hsieh S, Sakano K, Fujiwara H, Perdue JF, Rechler MM (May 1993). "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol. Chem. 268 (13): 9246–54. PMID 7683646.
- ^ Qin X, Strong DD, Baylink DJ, Mohan S (September 1998). "Structure-function analysis of the human insulin-like growth factor binding protein-4". J. Biol. Chem. 273 (36): 23509–16. doi:10.1074/jbc.273.36.23509. PMID 9722589.
- ^ Ahmed S, Yamamoto K, Sato Y, Ogawa T, Herrmann A, Higashi S, Miyazaki K (October 2003). "Proteolytic processing of IGFBP-related protein-1 (TAF/angiomodulin/mac25) modulates its biological activity". Biochem. Biophys. Res. Commun. 310 (2): 612–8. doi:10.1016/j.bbrc.2003.09.058. PMID 14521955.
- ^ Oh Y, Nagalla SR, Yamanaka Y, Kim HS, Wilson E, Rosenfeld RG (November 1996). "Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II". J. Biol. Chem. 271 (48): 30322–5. doi:10.1074/jbc.271.48.30322. PMID 8939990.
Further reading[edit]
- Butler AA, Yakar S, LeRoith D (2002). "Insulin-like growth factor-I: compartmentalization within the somatotropic axis?". News Physiol. Sci. 17: 82–5. PMID 11909998.
- Maccario M, Tassone F, Grottoli S, Rossetto R, Gauna C, Ghigo E (2002). "Neuroendocrine and metabolic determinants of the adaptation of GH/IGF-I axis to obesity". Ann. Endocrinol. (Paris) 63 (2 Pt 1): 140–4. PMID 11994678.
- Camacho-Hübner C, Woods KA, Clark AJ, Savage MO (2003). "Insulin-like growth factor (IGF)-I gene deletion". Reviews in endocrine & metabolic disorders 3 (4): 357–61. doi:10.1023/A:1020957809082. PMID 12424437.
- Dantzer B, Swanson EM (2012). "Mediation of vertebrate life histories via insulin-like growth factor-1". Biological Reviews 87 (2): 414–429. doi:10.1111/j.1469-185X.2011.00204.x. PMID 21981025.
- Trojan LA, Kopinski P, Wei MX, Ly A, Glogowska A, Czarny J, Shevelev A, Przewlocki R, Henin D, Trojan J (2004). "IGF-I: from diagnostic to triple-helix gene therapy of solid tumors". Acta Biochim. Pol. 49 (4): 979–90. PMID 12545204.
- Winn N, Paul A, Musaró A, Rosenthal N (2003). "Insulin-like growth factor isoforms in skeletal muscle aging, regeneration, and disease". Cold Spring Harb. Symp. Quant. Biol. 67: 507–18. doi:10.1101/sqb.2002.67.507. PMID 12858577.
- Delafontaine P, Song YH, Li Y (2005). "Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels". Arterioscler. Thromb. Vasc. Biol. 24 (3): 435–44. doi:10.1161/01.ATV.0000105902.89459.09. PMID 14604834.
- Trejo JL, Carro E, Garcia-Galloway E, Torres-Aleman I (2004). "Role of insulin-like growth factor I signaling in neurodegenerative diseases". J. Mol. Med. 82 (3): 156–62. doi:10.1007/s00109-003-0499-7. PMID 14647921.
- Rabinovsky ED (2004). "The multifunctional role of IGF-1 in peripheral nerve regeneration". Neurol. Res. 26 (2): 204–10. doi:10.1179/016164104225013851. PMID 15072640.
- Rincon M, Muzumdar R, Atzmon G, Barzilai N (2005). "The paradox of the insulin/IGF-1 signaling pathway in longevity". Mech. Ageing Dev. 125 (6): 397–403. doi:10.1016/j.mad.2004.03.006. PMID 15272501.
- Conti E, Carrozza C, Capoluongo E, Volpe M, Crea F, Zuppi C, Andreotti F (2005). "Insulin-like growth factor-1 as a vascular protective factor". Circulation 110 (15): 2260–5. doi:10.1161/01.CIR.0000144309.87183.FB. PMID 15477425.
- Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish". Int. Rev. Cytol. International Review of Cytology 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. ISBN 9780123646477. PMID 15797461.
- Sandhu MS (2005). "Insulin-like growth factor-I and risk of type 2 diabetes and coronary heart disease: molecular epidemiology". Endocrine development. Endocrine Development 9: 44–54. doi:10.1159/000085755. ISBN 3-8055-7926-8. PMID 15879687.
- Ye P, D'Ercole AJ (2006). "Insulin-like growth factor actions during development of neural stem cells and progenitors in the central nervous system". J. Neurosci. Res. 83 (1): 1–6. doi:10.1002/jnr.20688. PMID 16294334.
- Gómez JM (2006). "The role of insulin-like growth factor I components in the regulation of vitamin D". Current pharmaceutical biotechnology 7 (2): 125–32. doi:10.2174/138920106776597621. PMID 16724947.
- Federico G, Street ME, Maghnie M, Caruso-Nicoletti M, Loche S, Bertelloni S, Cianfarani S (2006). "Assessment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: a proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED)". J. Endocrinol. Invest. 29 (8): 732–7. doi:10.1007/bf03344184. PMID 17033263.
- Zakula Z, Koricanac G, Putnikovic B, Markovic L, Isenovic ER (2007). "Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes". Med. Hypotheses 69 (2): 302–6. doi:10.1016/j.mehy.2006.11.045. PMID 17289286.
- Trojan J, Cloix JF, Ardourel MY, Chatel M, Anthony DD (2007). "Insulin-like growth factor type I biology and targeting in malignant gliomas". Neuroscience 145 (3): 795–811. doi:10.1016/j.neuroscience.2007.01.021. PMID 17320297.
- Venkatasubramanian G, Chittiprol S, Neelakantachar N, Naveen MN, Thirthall J, Gangadhar BN, Shetty KT (October 2007). "Insulin and insulin-like growth factor-1 abnormalities in antipsychotic-naive schizophrenia". Am J Psychiatry 164 (10): 1557–60. doi:10.1176/appi.ajp.2007.07020233. PMID 17898347.
External links[edit]
- Insulin-Like Growth Factor I at the US National Library of Medicine Medical Subject Headings (MeSH)
- IGF-1 at Lab Tests Online


text:
Makes 6 to 8 servings
Ingredientsadd to shopping list
- 1 lb. smoked ham (cubed)
- 1/2 lb. chaurice* (hot sausage cut in pieces)
- 1/2 lb. smoked sausage (cut in 1/2-inch slices)
- 1 cup chopped onions
- 3 cups uncooked rice
- 1/4 cup chopped green onions
- 1/2 tsp. paprika
- 1 tbsp. chopped parsley
- 1 tsp. ground thyme
- 1 tsp. chopped garlic
- 1/2 cup chopped green pepper
- 1 tsp. salt
- 1 bay leaf
- 1 lb. shrimp (peeled and deveined)
- 4 cups boiling water
Place ham, sausages, and onions in 3-quart saucepan. Cover and cook over medium heat until onions are soft. No need to add any oil as the meat will provide enough fat for cooking. Add rice and stir well. Add all other ingredients. Bring to a boil. Let boil for 5 minutes. Lower heat. Cover pot tightly and let cook slowly for 35 minutes or until rice is tender. With a fork, fluff rice up, mixing sausages well.
*Editor's note: Chaurice is a freshly made (not precooked) hot sausage common in southern Louisiana. Any uncooked hot sausage can be substituted.
my notes
Nutrition Informationper serving (6 servings) POWERED BY Edamam
- Calories755
- Carbohydrates89 g (30%)
- Fat25 g (38%)
- Protein40 g (80%)
- Saturated Fat9 g (43%)
- Sodium2,195 mg (91%)
- Polyunsaturated Fat3 g
- Fiber1 g (4%)
- Monounsaturated Fat11 g
- Cholesterol156 mg (52%)
recipe featured in
recipe at a glance
main ingredients: Sausage, Onion, Ham, Bell Pepper, Rice, Shellfish
cuisine: Cajun/Creole, Southern/Soul Food
holiday/celebration: Mardi Gras


text:
I really didn't know what 'Topic' to put this under. I don't want surgery - thinking more along the lines of fillers for the upper lids/brow-bone and lower lids. I've read it can achieve a fuller lid and can be reversed if, I don't like it. I realize it's a temporary fix, but it will buy me some time before committing to a fat transfer procedure. Seeing my pictures, do you think it's possible to obtain a more refreshed, less sad look, with this type of treatment? Thank you in advance.
Orbital Fat Loss - What Can Be Done? I'm 49, my Eyes Look Much Older. (photo)
Doctor Answers (16)
Ptosis and hollow upper lids
Melody I would have to see you in person,but I think a good first step in improving your eyes would be doing a conservative upperlid bleph. with levator elevation. Any tissue harvested during the bleph. could possibly be used to make the upper lid concavity less severe. This is not saying that you still might need a filler in the upper lids.If you have fat injected in your upper lids I would suggest you see someone like Sydney Coleman M.D. the professor of fat injections.
Orbital fat loss
The pictures do show a orbital fat loss and very hollow upper lids. From the pictures is also apparent that there some ptosis present. Repairing the ptosis will reduce the aperture of the eyelid opening and help from raising the eyebrows to compensate for the ptosis. Best to seek out an oculoplastic surgeon well versed in ptosis repair and a possible small amount of fat grafting to the upper lids.
Web reference: http://eyelids.com
Fat depletion from eyelid areas
You do have hollowing around the eyes from loss of fat tissue support. A fat transfer or filler (done with a very experienced injector who is comfortable working in this area) is a good solution.
Before you proceed get an evaluation for the droopy upper eyelids that come from weakening of the upper eyelid "lifting" muscle, (called "ptosis") to see if you need a tightening procedure. That will also help make you look less hollow.
Good luck. I think your objectives are possible.
You might also like...
Eyelid ptosis
Looking at your photos, it seems that your upper eyelids are somewhat droopy [eyelid ptosis]. Furthermore, I think that you are subconsciously elevating your eyebrows to compensate for this.
Raising your eyelids [ptosis repair] will definitely help your upper eyelids become less hollow. But you should be aware that your subconscious drive to raise your eyelids may go away and unmask a mild droopy eyebrow.
I would recommend consultation with an Oculoplastics surgeon [or a Facial Plastic surgeon or General Plastic surgeon that has extensive experience with eyelid ptosis repair].
You can find an ASOPRS trained Oculoplastics surgeon near you. The link is provided below.
Web reference: http://www.asoprs.org/custom/directory/?pageid=3657&showTitle=1
Combination of upper eyelid ptosis and hollowness of lower eyelids
Depending on what is truly bothering you the most, you have several options to rejuvenate your eyes. It appears as if you may have ptosis of the upper eyelids which can be treated with a fairly simple procedure and would help "brighten" your eyes. You also have hollowness under your lower eyelids which can be treated with in office injections with restylane or juvederm or autologous fat transfer. These results can last anywhere from 6 months to several years depending on the modality chosen.
Address eyelid ptosis first
Before considering fillers, please be seen by an oculoplastic surgeon (an ophthalmologist who does eyelid surgery) and have an evaluation for eyelid ptosis. That may be more of what you have than fat loss. Also, when considering fillers, you can always have a saline injection to see if you like the effect. This will go away in a few hours but the amounts and technique can be determined for you if you happen to like it and want to convert to HA's.
Orbital Fat Loss - What Can Be Done? I'm 49, my Eyes Look Much Older.
Great question and posted photos. Options are fillers like HA's or fat grafts. Best to obtain in person opinions.
Orbital Fat Loss - What Can Be Done? I'm 49, my Eyes Look Much Older.
You do appear to have a deep or hollow upper eyelid sulcus. In your case, this results from drooping upper eyelids. Not extra skin, rather excess laxity in the eyelid elevating muscle. This condition is called upper eyelid ptosis and can be repaired. This should improve the appearance of your upper eyelids and should be performed before considering adding any fillers to this area. I hope this information is helpful.
Stephen Weber MD, FACS
Weber Facial Plastic Surgery
Web reference: http://weberfacialplasticsurgery.com/blepharoplasty/
Eyelid Injections Instead of Surgery?
You are correct that we can very often temporize surgical rejuvenation with volumizing injections in the eyelid area. But from the pictures provided, it would seem you could have a medical condition that might require addressing first. Ptosis is a condition in which your eyelids can't be raised fully- when your upper eyelids are in a perpetual state of "half mast". My advice? Get yourself examined before anyone puts any fillers or fat into or around your eyelids. I think you'll find that ptosis repair might solve much of your distress over the appearance of your eyes. Thanks for the question! -Dr. Capone
Upper Eyelid Ptosis and Volume Loss
I would agree there is some volume loss, but the eyelid ptosis is noticeable and should be corrected. Kenneth Hughes, MD Los Angeles, CA
Web reference: http://www.hughesplasticsurgery.com/Upper-and-Lower-Eyelids.php
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


text:
"We are transitioning our dialysis service over to DaVita. They will be the provider over here in Great Falls", Benefis Hospice President Laura Goldhahn says.
The dialysis unit at Benefis has 25 staff members who care for 125 patients. But President Laura Goldhahn insists that despite myths of poor service after being sold to a billion dollar corporation the quality of care will only improve.
"For our patients, the transition should be seamless. they will continue to be provided care from the same nurses because DaVita has hired the employees we had working there" she stated.
Goldhahn says the new ownership process was initiated by Benefis for growth.
"We were the ones to approach and say, as we look to the future we think we need someone with more expertise then what we're going to be able to provide going forward.", she told us.
DaVita operates more than two thousand outpatient clinics, which Goldhahn says will be a huge benefit for the dialysis unit in the long run.
"They'll bring a higher level of training resources of clinical resource and also a buying power in terms of the drugs and supply side of dialysis centers that we simply could not do on our own."


text:
Four year fire dispute over (From Basildon Recorder)
Get involved: send your pictures, video, news and views by texting ECHONEWS to 80360, or email us »
Four year fire dispute over
8:44am Wednesday 24th October 2012 in News
FIREFIGHTERS have reached an agreement with the fire service after a long running trade dispute.
A series of strikes were held over the summer following a four year battle between the Fire Brigades' Union and the Essex County Fire and Rescue Service.
The union had claimed planned changes by the fire service could cost lives and were not in the best interests of residents.
However the FBU accepted the offer by the fire service late last night and all future strikes have been called off.
Comments (3)
Please log in to enable comment sorting
10:23am Wed 24 Oct 12
wellnow says...
11:46am Wed 24 Oct 12
HadleighBoy says...
2:30pm Wed 24 Oct 12
Old Boy says...
Comments are closed on this article.


text:
Coach: kaskier7 [at] yahoo [dot] com (Dawson Emrich) 970-749-3466
Manager: nancy [dot] shanks [at] state [dot] co [dot] us (Nancy Shanks) 970-799-1294
Practices: Monday & Wednesday, 6-7:30 pm at Escalante Middle School
U16 United Photo Gallery
U14 Girls Take Championship at Gaylord Shepperd
The tough competition was no match for DYSA's U 14 girls, Durango En Fuego ('on fire') at the Gaylord Shepperd Tournament on November 19-20. Lead by head coach Bree Baker (FLC assistant coach, women's soccer) and assistant coaches Cassie Seaney and Joe Casey (both freshmen, FLC Skyhawks), the girls finished a strong season by taking the silver bracket championship at the annual New Mexico tournament. Durango En Fuego won its first three games of the weekend 2-0, 2-1 and 3-2; then shut out NM Rush's Barcelona 3-0 for the championship (a team that had bested En Fuego 3-2 in a recent league match.)
"We had a great season, scores aside, because the girls became better in every way--individually and as a team," Baker said. "If every season is like that, you're a lucky coach."
The young team--in just their third season together--finished up a solid season in New Mexico's Duke City Soccer League with a win-loss-tie record of 5-2-1.
Top Row, left to right: Clare Carroll, Elli Earl, Maddie Robertson, Chloe Ciotti, Maddy Duran, Katie Milliet, Ellie Gervais, Sydney Mattox, Naomi Marquez, Raeden Shanks, assistant coach Cassie Seaney.
Front Row, left to right: Leah Stephens, Lauran Morrissey, Becca Schaldach, Sarah Waller, Ashlee Scalf
(not pictured are Kirsten Lloyd, Julianne Marqua and Hayden Stills)


text:
when I modify my .svg file for the icon (either for the emulator or the device), it doesn't show me the last one, it seems that the .mif file is not rebuild by carbide.vs !! is it true ? must I rebuild by myself thru a command line ? if yes, which one ?
PS: the project is generated inside the VS .Net thru file/new/project/new symbian os project ; I have changed nothing to the file, I only want to modify the gfx/qgn_menu.svg file ...
Thanks 4 your help,


text:
Skipper's Escape in Destin
- bedrooms 5
- baths 5½
- sleeps 16
- pool yes
- hot tub no
- pets allowed yes
- type House
- community Crystal Beach
rates (USD)
/ night
$ 1,800 - $ 5,200 / week
$ 2,200 - $ 2,200 / month
vacation rental description
***Minimum renting age is 25 years old*** No college or high school groups!
ESCAPE to this fun 5 bedroom, 5.5 bath house sitting just steps away from the sugar white sand of Crystal Beach in Destin, Florida! The nearly 3000 sq. ft. house features a private heated pool, guest cottage, tile throughout, and great views of the beautiful gulf waters. Listen to your favorite CD with the surround sound system both inside and out.
The pool area includes an outdoor shower, large gas grill, chaise lounges, and many chairs to enjoy the sun. The spacious living room has a 55" plasma TV with expanded cable, stereo, and DVD player. Each bedroom has a TV and DVD player with cable, and the bunk room has a TV/DVD combo with cable. Destin Commons outdoor shopping mall, with stores like Bass Pro Shop, Abercrombie & Fitch, Victoria's Secret, Talbots, Books A Million, and a 14 movie stadium seating theater, along with countless fantastic restaurants! Walking distance to nearly everything you could want on your vacation including Camille's Restaurant for your morning coffee.
Your vacation time here is sure to be relaxing and enjoyable. Sleeps 16.
Main House
First Floor: Screened-in porch, living room with a 32" flat-screened TV and DVD player, queen sleeper sofa, fully equipped kitchen, dining area, ½ bath walking in from the pool, full-size washer and dryer, king bedroom with private bath and porch area.
Second Floor: Master suite has great views of the gulf, king bed, private bath with Jacuzzi, balcony; queen bedroom with private bath and porch; bunk room with a twin top and a double bottom bunk and separate twin bed, full bath.
Third Floor: Loft with two porches to enjoy the view of the Gulf.
Guest House
Living room with queen sleeper sofa, TV with cable, DVD player, kitchen area with coffee maker, refrigerator, microwave, and sink, hall bath, and king bedroom with TV.
vacation rental location
property availability
- dates with deals
- unavailable dates
Last modified on 09-1-2014 at 10:11 AM.
email owner view full calendar
Janet or Chris Kiley
house rental amenities
- Private pool with outside speakers, gas grill, large deck, and plenty of seating.
- Beach views from 2nd and 3rd floors
- Linens/towels provided
- Washer/dryer
- Secure WiFi available
- Cable TV/DVD players in all bedrooms, living areas
- CD changer with stereo system and surround sound and iPod connector
- Full kitchen with separate ice machine, waffle maker, crock pot
- Beach chairs, pool and beach toys, pool floats, rolling cooler, child wagon, push cart to take items to the beach
- Non-Smoking
- Small pets considered
activities and attractions in Destin Gulf Coast North
- Golf
- Sailing
- Parasailing
- Swimming
- Fishing
- Amusement Parks
- Restaurants
- Boating
- Jet Skiing
- Cinemas/movie theaters
- Shopping
- Waterskiing
- Biking
- Miniature golf
vacation rental rates
2014 Rates
Mar. 1-7 $350/nt $2400/wk 3 Night minimum
Mar. 8-Apr. 25 $3500/wk 7 Night minimum
Apr. 26 - May 9 $475/nt $2800/wk 3 Night minimum
May 10 - May 23 $3200/wk 7 Night minimum
May 24 - May 30 $4400/wk 7 Night minimum
May 31 - Jun. 27 $4800/wk 7 Night minimum
Jun. 28 - Jul. 4 $5200/wk 7 Night minimum
Jul. 5 - Aug. 1 $4800/wk 7 Night minimum
Aug. 2 - Aug. 15 $3500/wk 7 Night minimum
Aug. 16 - Aug. 22 $2800/wk 7 Night minimum
Aug. 23 - Sep. 5 $475/nt $2800/wk 4 Night minimum
Sep. 6 - Oct. 31 $325/nt $1800/wk 7 Night minimum
Nov. 1 - Feb. 28 $325/nt $1800/wk 3 Night minimum
Thanksgiving & Christmas - $2200/wk Jan & Feb - $2300/mo
Fees not included in above rate: $325 cleaning, 3% reservation, and 11% tax
Pool heating available for additional fee
Small dogs considered (max 2 under 30 lbs.)
Janet or Chris Kiley
accepted payment methods
Prior to paying a reservation deposit, always verify payment instructions by calling the phone number displayed on this listing page. By contacting the owner directly and paying by an approved method - credit card, paypal, check or bank transfer - your reservation payment will be protected up to $1,000.Learn more in our Security Center


text:
The Detroit Wallpaper Company offers designers and consumers unique wallpaper with a keen interest to innovate the art form.
Creators of the Detroit Wallpaper Company, Andi and Josh, find inspiration from travel and pop culture. Their wallpaper includes six original collections, Botanicals, FABrics, Metrix, Sprout, Wallgazer and Wander Walls.
The collections can be further explored on the Detroit Wallpaper Company's website. Andi and Josh's wallpaper is based on clean, modern design for both kids and parents. The wallpaper comes in many different designs and colors. It comes in pre-pasted rolls that are strippable.For more information, visit www.detroitwallpaper.com.
KTTV FOX 111999 S. Bundy Dr.Los Angeles CA 90025Main: (310) 584-2000News Tips? (310) 584-2025


text:
(Covington) – Mary Bird Perkins Cancer Center at St. Tammany Parish Hospital is hosting two free prostate cancer screenings during September.
An appointment is required. Call 888- 616-4687 for more information.
The prostate screening includes a PSA blood test and a physical exam performed by a physician. The screening is available to men 45 and older who do not have a doctor or who have not been screened for prostate cancer in the past 12 months.
Mary Bird Perkins Cancer Center at St. Tammany Parish Hospital provides comprehensive cancer care that strives to positively impact the lives of cancer patients and their families on the Northshore. Services include chemotherapy, radiation therapy and surgery, as well as patient navigation, clinical trials and free community screenings. Not only do patients have access to these vital cancer services and high quality cancer care, but these services are readily available close to home.


text:
Food & Recipes
Sodium Directory
Sodium News Archive
Sort by: Date A-Z
- 'Western' Diet Is a Global Heart Risk
- 90% in U.S. Get Too Much Sodium; 5 Foods Blamed
- AMA Balks at a Low-Salt Diet for All
- Americans Advised to Cut Salt, Follow Thirst
- Americans Advised to Cut Salt, Follow Thirst
- Are you taking in more salt then current guidelines recommend?
- Chicken Nuggets Loaded With Fat, Salt
- Chinese Restaurants: Calories Galore
- Cut Heart Risk by Eating Less Salt
- Cut Hypertension Drugs With Low-Salt Diet
- Cutting Salt as a Teen May Help Heart Later
- Cutting Salt as Good as Quitting Smoking
- Debate Over U.S. Plan to Cut Salt in Diet
- Denny's Sued Over Salty Food
- Experts Urge FDA to Mandate Salt Reduction
- For Some Women, Limiting Salt Can Drastically Lower Health Risks
- Group Wants FDA to Cut Salt in Foods
- Group Warns of 'Extreme' Restaurant Meals
- Group: Too Much Salt in Restaurant Food
- Is Salt Really So Bad?
- Lawsuit Asks FDA to Regulate Salty Foods
- Less Salt Is Often Still Too Much
- Less Salt Will Cut Heart Disease Rate
- Link Between Blood Pressure and Salt Stirs Up Seasoned Debate
- Sack the salt, experts say.
- Salt Lurks in Unsuspected Foods
- Salt May Restrict Blood Flow to Heart
- Salt Sensitivity Increases Heart Disease Death Risk
- Salt Substitute May Help Hearts
- Salt Tied to Heart Disease in the Overweight
- Salty Diet Linked to Stroke Risk
- Salty Diet Makes Ulcer Bug Bite
- Salty Diet Might Help Trigger MS, Rheumatoid Arthritis
- Shaky Amount of Iodine in U.S. Salt
- Smoking, Extra Salt Increase Heartburn Risk
- Spoonful of Salt Helps the Medicine Go Down
- Study Shows Salty Diet Good, Heart Group Disagrees
- Too Much Salt Hurting Majority of Americans
- Watching Salt Intake Won't Ease Asthma
- Wine, Salt, and Your Heart: Confusion Abounds
Today on WebMD
What condiments are made of and how much to use.
How to get what you need.
Easy ideas for dinner tonight.
Health benefits, what you can eat and more.
WebMD Recipe Finder
Browse our collection of healthy, delicious recipes, from WebMD and Eating Well magazine.


text:
One man is recovering after a rollover accident in Independence.
Authorities responded to the 2200 block of 155th Street at 2:37 p.m. Tuesday for a car rolled over in the ditch.
Authorities say Lester Steffens of West Union was driving westbound on 155th street when he lost control of the car he was driving, and drove into the ditch. The car then rolled over onto its top.
Steffens was taken to the Buchanan County Health Center with minor injuries.


text:
Please vote below for your favorite meme!
When Harry Redknapp was manager of Tottenham Hotspur, he told an interpreter to tell Roman Pavlyuchenko to "just fucking run around a bit!" during the Russian's first appearance with the team under him. The phrase (and acronym) has become synonymous with Redknapp's lack of true tactics.
After a foul, Swansea City captain Ashley Williams attempted a clearance that drilled Manchester United striker Robin Van Persie in the head from only a few feet away. Sir Alex Ferguson, in his typical level headed manner, had a perfectly reasonable opinion on the matter.


text:
Tag Archives: Collisions
David A. Amador of High School Sports Magazine will do anything to get his shot, including taking a devastating hit from a large and oblivious
That's Brandon Douglas of the Erie SeaWolves running and Brian Jeroloman getting just fuckin' crushed. The bone-jarring play happened during a playoff game, so perhaps
Baseball isn't usually a contact sport – but it can be when an out-of-control skydiver comes into play.
Look out!
Move, female. Get out the way.
Arizona Diamondbacks catching prospect Stryker Trahan has a bright future in addition to his awesomely badass name. He also has an iron shoulder, which he


text:
Will the jury be a bunch of bitter bitches intent on punishing the most deserving and rewarding the least offensive? It certainly wouldn't be the first time.Survivor: Redemption Island Episode 13 5/11/11 | Jeff Probst
Jeff Probst - Survivor Video Blog Week 12
Survivor: Video Blog 4/27/11
Stealth-R-Us. Phillip is pure gold. Straight out of the river bed. If there has ever been a more fascinating Survivor contestant, please share.Survivor: Redemption Island Episode 9 4/14/11 | Jeff Probst
Rob is so in control I think he even yelled to our camera operator, "We gotta move" as if to say — if you want to get the shot of me trading out the idol notes, then you better start running, because I have no time to waste!Survivor: Redemption Island Episode 5 3/16/11 | Jeff Probst
Nobody integrates product as well as we do. Last night you watched an incredibly dramatic challenge that was built all around tools from Sears.Survivor Redemption Island Episode 4 Blog 3/10/11 | Jeff Probst
Historic Moments in time: Jan. 10th , 1935 Canned Beer invented May 6th, 1954 – First Sub-Four Minute Mile July 20th, 1969 – Apollo 11 lands on the moon March 2nd, 2011 – Russell Hanz voted out of Survivor: Redemption IslandSurvivor: Redemption Island – Episode 3 Blog 3/2/11 | Jeff Probst
As part of the new SB Nation launch, prior users will need to choose a permanent username, along with a new password.
Your username will be used to login to SB Nation going forward.
Please login to your Vox Media account. This account will be linked to your previously existing Eater account.
As part of the new SB Nation launch, prior MT authors will need to choose a new username and password.
Your username will be used to login to SB Nation going forward.
We'll email you a reset link.
If you signed up using a 3rd party account like Facebook or Twitter, please login with it instead.
You must be a member of Uncommon Sportsman to participate.
We have our own Community Guidelines at Uncommon Sportsman. You should read them.
You must be a member of Uncommon Sportsman to participate.
We have our own Community Guidelines at Uncommon Sportsman. You should read them.
Choose an available username to complete sign up.
In order to provide our users with a better overall experience, we ask for more information from Facebook when using it to login so that we can learn more about our audience and provide you with the best possible experience. We do not store specific user data and the sharing of it is not required to login with Facebook.


text:
Evanna Lynch, Domhnall Gleeson, and James and Oliver Phelps Attend Dublin Premiere of "DH: Part 2"DH Film
Evanna Lynch (Luna Lovegood), Domhnall Gleeson (Bill Weasley), and James and Oliver Phelps (Fred and George Weasley) recently attended the Dublin premiere of "Harry Potter and the Deathly Hallows: Part 2." We have some images of them posing near a "Deathly Hallows: Part 2" poster here in our galleries. Enjoy!
Many thanks to Snitchseeker!


text:
By MIKE KRAFCIK6 News Reporter
KNOXVILLE (WATE) - Three protesters on trial for trespassing on the Y-12 National Security Complex were found guilty Wednesday on all charges.
Upon hearing the guilty verdict, Michael Walli, Sister Megan Rice and Greg Boertje-Obed, members of Transform Now Plowshares remained relaxed, perhaps even joyous.
The three even sang along to protest hymns before being handcuffed and taken into custody.
The three were on trial for trespassing on Y-12 property last summer, cutting fence, spreading human blood and spray painting messages.
"They're at peace about this, they're peace makers, and they knew that they risked this. Nobody is happy to go jail but they understand," said Joe Quigley, attorney for Michael Walli.
All three took the stand Wednesday before the defense rested their case. The three defendants admitted to breaking in to the complex as part of a nuclear weapons protest.
They face sentencing on two charges: willingly destroying government property under what's known as The Sabotage Act and "depredation against property of the United States" with damages exceeding $1,000.
Sentences of up to 30 years in prison are possible.
Rice took the stand first Wednesday and was cross-examined by prosecutors. When asked about violating U.S. laws, she said the protestors were keeping the law of the land.
Rice said she considers herself a citizen of the world and said that all boundaries were "arbitrary."
She described her career and said she had spent over 40 years in Africa. She testified that she was inspired to break in to the Y-12 complex after seeing a break in at a submarine in California.
Rice also said she didn't regret what she had done, only that she had not done it sooner, "My guilt is that I waited 70 years to speak," she testified.
Michael Walli took the stand next and described his background, including his service in Vietnam and time spent homeless.
When asked by prosecutors whether he believed they committed crimes at Y-12, Walli said the group's actions were morally equivalent to cutting the fences at Auschwitz in Nazi Germany.
Walli also discussed a previous felony conviction in which he said he and a Catholic priest entered a missile silo in North Dakota.
In his testimony, Greg Boertje-Obed echoed the sentiments of his co-defendants saying the group did not mean to harm the Y-12 facility or national security in general.
Like Rice and Walli, Boertje-Obed said he had no remorse over the incident and was glad he did it.
During the closing arguments, the defense argued that offering bread and lighting candles was a symbol of offering peace, and not destruction.
When prosecutors insinuated that he trespassed on the property for media attention, Boertje-Obed said the group only talked to media when approached and did not seek it out.
Defense attorneys argued that the protestors did not harm or threaten national security, and that they, in fact, helped by exposing a weakness in security at the Y-12 complex.
Attorney Joe Quigley said that being for disarmament is not the same as intending to injure national defense.
"Don't blame the thermometer for the fever," he said. "They were the thermometer that pointed out the fever."U.S. Assistant Attorney Joe Theodore argued that Y-12 is a unique facility that contributes to national defense.
"When you are interfering with Y-12, you are interfering with national defense," he said.
Theodore compared the situation to a home burglary. If a burglar breaks in to your home and you didn't have sufficient security, is it the homeowner's fault?
Theodore added that it was clear the protesters meant to interfere with national security, "Why else would they go there," he said.
Anne Wright testified as a security expert on behalf of the defense. Wright served 29 years in the U.S. Military, and says she oversaw embassies across the world.
She helped to reopen the U.S. Embassy in Kabul, Afghanistan, in December 2001, before resigning because of the U.S. involvement in the Iraq War
Wright is currently a self-proclaimed "peace protester."
Wright offered her opinion that the group never posed a real security risk.
Wright contends the complex didn't mean security was threatened because the group never had malicious intent, she contends.
Wright says Oak Ridge is more secure today than it was before the July 28th breech.
The case was handed over to the jury, which is made up of nine men and three women, just after 4 p.m.
A verdict was returned around 6 p.m.
"They are kind of like modern day martyrs. Especially if they have a long sentence," said Jerry Dawada, a Transform Now Plowshare protester.
"It's very rarely when has the government has given a sabotage charge had they lost," said Patrick O'Neil, a writer for the National Catholic Reporter.
O'Neil has covered around dozen Now Plowshares cases since the 1980s.
Rice, Walli and Boerjte-Obed all say they were led by the spirit and religious beliefs.
Motivations that were likely a tough sell for jurors, according to O'Neil.
"These are jurors who are coming into the case and it's very different, very unusual, very out of the range of anything considered normal. To get an acquittal on this you would have to have someone with some very deep spiritual thinking, " O'Neil said.
The three were placed in custody after the verdict was read and were taken to the Blount County Detention Center.
Federal prosecutors contend that a congressional mandate requires individuals convicted under the "Sabotage Act" to remain detained until the sentencing hearing.
U.S. District Judge Amul R. Thapar said the congressional ruling was written was unclear, and that he would study the guidelines overnight.
The judge said he make a determination during a Thursday hearing at 9 a.m.
Defense attorneys have asked the judge to throw out the sabotage conviction, based on what they believe is a lack of evidence.
"We still have a chance to wipe that decision out in the next couple weeks," said Joe Quigley, attorney for Michael Walli.
1306 N. Broadway NE Knoxville, Tennessee 37917
Telephone: 865.637.NEWS(6397)
Fax: 865.525.4091
Email: email@example.com