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Whether you are an existing customer, new to Origin, moving house, or just wanting to compare Origin's energy plans, we can help. Tell us a little bit about yourself, your household energy use, and what sort of plan you are looking for, and we will show you the options Origin has available online.
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Origin also offers a Standing Offer which is a no lock in, no base discount product with terms and conditions set under the National Energy Retail Rules. Different charges apply for our natural gas standing offer. For current pricing, please refer to the price fact sheet. To find out more please call us on 13 24 63.
Origin also offers a Standing Offer and for natural gas a Regulated Offer which are both no lock in products with terms and conditions set under the National Energy Retail Rules. For current pricing, please refer to the price fact sheet. To find out more please call us on 13 24 63.
Plan discounts apply to Origin's market contract usage charges and not Origin's transitional charges. Transitional standard retail contract customers should consider what's best for them before switching plans, transitional charges have lower supply and usage charges. Find out more.


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Eagles Prepare to Host Mercer on Senior Day
FORT MYERS, Fla. – The FGCU softball team will close out the 2010 season on Saturday when they host the Bears of Mercer in a doubleheader at the FGCU Softball Complex. First pitch for game one is slated for 2 p.m. Seniors Jessica Gary (Naples, Fla.), Hayley O'Mara (Naples, Fla.), and Lauran Ziegler (Palm Bay, Fla.) will be honored in between games.
The Eagles bring a 22-28 overall mark into the doubleheader, with a 10-8 record in conference play. Last weekend, the Blue and Green earned a split of a four-game road trip to Nashville, Tenn. FGCU swept Belmont on Friday afternoon before dropping a pair of games at Lipscomb on Saturday.
Gary leads the team in hitting with a .348 average, along with seven home runs, 27 RBIs, and 11 steals. Ziegler leads the A-Sun with 58 hits and is second in the conference with 24 stolen bases. Courtney Platt (Greenville, Ohio) continues to lead the team with nine homers and 31 RBIs.
Mercer (22-27, 4-10 A-Sun) is led by Holly Oglesbee, who is hitting .310 with 19 RBIs. Kristin Marko leads the team in home runs with seven, in addition to 18 RBIs and a .294 average. In the circle, Jenni Holtz has a team-high 14 wins and is second in the Atlantic Sun with 303 strikeouts.
Saturday's doubleheader will mark the final games in the careers of FGCU seniors Jessica Gary, Hayley O'Mara, and Lauran Ziegler. All three of them played integral roles on last year's team that finished 47-9 and was ranked as high as 18th in nation. A ceremony to honor the Eagle seniors will take place in between games.
Prior to the first game, the Children's Miracle Network will be in attendance and a child from the All Children's Hospital will be throwing out the first pitch.
About All Children's Hospital
Children are the sole focus of All Children's Hospital and its new, million-square-foot St. Petersburg FL campus devoted to pediatric specialty care. The ten-story All Children's Hospital and its adjacent Outpatient Care Center (dedicated in January 2010) replace an existing 42-year old facility just two blocks away.
All Children's Hospital is the only hospital on Florida's West Coast totally devoted to children's care - a leader in pediatric treatment, education, research and advocacy. As a regional referral center for children with some of the most challenging medical problems, All Children's draws patients from throughout Florida, all 50 states and 36 foreign countries. The mission of this private, not-for-profit hospital is rooted in its beginnings in 1926 as Florida's first Crippled Children's Hospital for polio victims. All Children's understands that it's not enough to treat disease -- that true progress comes from teaching and research to cure disease. All Children's shares its pediatric expertise through research & education affiliations with the University of South Florida (USF Health) as well as Moffitt Cancer Center, an NCI-designated Comprehensive Cancer Center.
|Copyright ©2014 FGCU Athletics. All Rights Reserved.

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Decorative Buddha head statue is made of terra-cotta from the royal state of Rajasthan in India. The Buddha head sculpture is hand-painted in traditional style of the region and measures 7 inches high and 5 inches wide. Handmade, no two pieces are identical. Celebrate your spirituality and bring home a decorative and inspirational Buddha statue.
Goldstone Beads Happy Buddha Charm Bracelet


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Gold Prices Surge As Bernanke Speaks
NEW YORK (TheStreet) -- Gold prices surged Tuesday as Federal Reserve Chairman Ben Bernanke gave the yellow metal a boost with his assertion that the central bank would continue a policy of low interest rates.
Gold for April delivery settled up $28.90 at $1,615.50 an ounce at the Comex division of the New York Mercantile Exchange. The gold price traded as high as $1,619.70 and as low as $1,583.70, while the spot price was popping $20.90, according to Kitco's gold index.
"He [Bernanke] says asset purchases will continue, and then throughout the testimony one of the things he said is that while he supports the Japanese fight against deflation, what does that mean? More easy money, more money printing, and clearly that's a good thing for gold in the medium term," Axel Merk, chief investment officer of Merk Investments, said in an interview.
Senators barraged Bernanke for some two hours with questions about the economy and the Fed's role in maintaining low inflation rates and reducing the unemployment rate -- the bank's "dual mandate.""Notably, keeping longer-term interest rates low has helped spark recovery in the housing market and led to increased sales and production of automobiles and other durable goods," Bernanke said in his testimony. "By raising employment and household wealth--for example, through higher home prices--these developments have in turn supported consumer sentiment and spending." Silver prices for March delivery added 27 cents to $29.26 an ounce, while the U.S. dollar index was slipping 0.05% to $81.85. "I think there was some noise a few weeks ago about the Fed potentially giving up on monetary stimulus; I think it's premature for that," said Troy Logan, senior economist at Warren Financial Service. "I think the Fed is going to be accommodative for a while. So they're going to continue to support the economy." Gold mining stocks closed mostly higher on Tuesday. Shares of NovaGold Resources popped 4%, while shares of Randgold Resources (GOLD) rose 3.5%. Among volume leaders, Barrick Gold (ABX) was up 1.5% Gold ETF SPDR Gold Trust (GLD) added 1.2%, while iShares Gold Trust (IAU) jumped 1.3%. -- Written by Joe Deaux in New York. >Contact by Email. Follow @JoeDeaux
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State plans lottery for firewood lotsDecember 09,2012State plans lottery
for firewood lots
WATERBURY Vermonters will have a chance to cut their own firewood from state forests.
This year, roadside lots are available in Plymouth, Shrewsbury, North Duxbury, Orange, Roxbury, Johnson, Groton, and Westmore.
The lottery for the cut-your-own lots opens on Jan. 2 and ends Jan. 18.
Lottery winners pay $30 for a lot that yields about three cords of wood from trees marked for removal. The firewood is suitable for the 2013 home heating season.
Lottery winners will be notified in March.
Registrations are available at the Vermont Department of Forests, Parks and Recreation website at www.vtpr.org or call 241-3678 for more information.MORE IN This Just InThe city is making free parking available for Sen. Jeffords' funeral. Full StoryPittsford seeks Full StoryAfter fire, city issues order to boil water Full Story
- Most Popular
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- TOMORROW'S HEADLINES TODAY: Jim Jeffords' legacy, Brandon takes a few questions about proposed budget, beleaguered city playground likely to move, woman awakes to find strange man with knives standing at her bedside.
- TOMORROW'S HEADLINES TODAY: Former U.S. Senator James Jeffords dies Monday in Washington D.C., a local man is beaten and robbed while walking on West Street, Clarendon sets a tax rate and Brandon convenes an informational public meeting about its budget.
- RICHARD'S POOR ALMANACK: On this day in 1915, the New York World publishes scoop: Thom. Edison diverts chemical from war production to help German pharmaceutical company make aspirin; on this day in 1935, Will Rogers, Wiley Post die in Alaska plane crash.
- TOMORROW'S HEADLINES TODAY: State panel briefed on smuggling drugs into prisons; new French-German documentary about Vermont's heroin addiction; solar project at Vets Home falls apart; update dispute between Open Door Mission and treatment center.
- TODAY'S WEATHER MINUTE: Climatologists might not know as much about El Nino as they thought they knew. New studies show 10,000 years ago, El Nino was active, and polar ice sheets were rapidly melting — just like today.
- TOMORROW'S HEADLINES TODAY: State colleges get a budget cut break, vandals spray paint Wallingford basketball court, state's attorney will replace lost deputies, cop lawsuit proceeds, Mendon mini-golf proposal makes headway.


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A meatless clinical animal diet for use in nutritional management of adverse food reactions in both dogs and cats. Entirely vegetarian, containing no meat or meat by-products. Designed ... Learn More
A meatless clinical animal diet for use in nutritional management of adverse food reactions in both dogs and cats. Entirely vegetarian, containing no meat or meat by-products. Designed to be used with meats which are non-allergenic for your specific animal. Does not achieve feline protein recommendations. This product is intended for intermittent or supplemental feeding only.
Reviewed by 1 customer
Best Uses
Comments about Wysong Vegan Canine/Feline Diet:
Though this is a vegan dry pet formula sold as being for both cats and dogs, please see the below for more information. This is from the Wysong website:
**A natural meatless vegetarian dog and cat food designed to be used with an alternative fresh meat source, or in conjunction with other Wysong meat based diets such as Archetype™ and the Au Jus™ canned diets.
Rich in vitamins, minerals, probiotics and enzymes.
Vegan does not meet minimum protein requirements for cats.**
My dog ate it with no problem, but he'll eat anything so that's not a big endorsement. =) While his coat was less flaky, his feces were dry and hard and seemed harder to pass. The cats would eat it, but didn't seem overly thrilled over it. I'll be mixing the remainder with other vegan cat/dog foods while I transition them to a different brand of food.
Ground Corn, Ground Extruded Whole Soybeans, Corn Gluten Meal, Ground Wheat, Oat Groats, Ground Brown Rice, Cane Molasses, Tomatoes, Ground Flax Seeds, Sun-Cured Alfalfa Meal, Dicalcium Phosphate, Wheat Gluten, Rice Gluten, Barley Sprouts, Canola Oil, Soybean Oil, Dried Yeast, Ground Sesame Seeds, Taurine, DL-Methionine, Salt, Dried Wheat Grass Powder, Dried Barley Grass Powder, Yeast Culture, Lecithin, Natural Extractives of Cloves, Sage, and Rosemary, Dried Kelp, Garlic, Black Pepper, Artichoke, Dried Bacillus subtilis Fermentation Product, Dried Aspergillus oryzae Fermentation Product, Dried Entercococcus faecium Fermentation Product, Dried Lactobacillus acidophilus Fermentation Product, Dried Lactobacillus casei Fermentation Product, Dried Lactobacillus lactis Fermentation Product, Dried Aspergillus niger Fermentation Product, Ascorbic Acid, Zinc Proteinate, Iron Proteinate, Vitamin E Supplement, Niacin Supplement, Manganese Proteinate, Calcium Pantothenate, Thiamine Mononitrate, C
Wysong, a unique company trying to make a difference in the world. At Wysong they are not marketers but are staffed by doctors and scientists specifically dedicated to achieving optimal health with products and information of conscience. Wysong is a 25-year treasure of products for you, your family, and your pets. If you are serious about health, if thinking matters to you, this is where you can get honest and competent information about holistic nutrition, vitamins, premium pet food for dogs, cats and ferrets .
A prescription is required for this product. Once we receive your order, we'll quickly contact your vet and ship your prescription within one business day of receiving approval.* If you have a prescription in hand, select the "mail my prescription" option during checkout.
*UPS doesn't ship on Saturday, Sunday, and most holidays. Note: If you are ordering medication, shipping is not available in the following states: LA


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People Who Sound Like Kermit The Frog
In the year of our Lord 1990, Jim Henson, the famous puppeteer and voice of Kermit The Frog, passed away. He died before his time from sudden illness. This was a very sad day. No more Jim Henson, and no more Kermit The Frog. But wait, Kermit The Frog still lives! He's still on tv and in movies, he still has a voice.
How is this possible? It's not. Except for the very small possibility that someone else is doing the voice. It sounds crazy, but it's possible.
Since googling this and quickly finding out the answer seems complicated and like something a lazy hack writer would do, I've instead compiled a list of two suspects.
Eugene Robinson, and Beth Karas.
Eugene Robinson is the overrated, boring, predictable, shallow columnist for the Washington Post. That rag. He also won a Pulitzer prize, likely for puppeteering. Listen to Kermit suspect number 1:


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Our policy prohibits comments that are:
Judging from the picture, it looks like, at least the windows have been pretty well destroyed already.
I hope that a good Home was found for the 3 Manual EM Skinner Pipe Organ, the Stained Glass Windows and the Pews and other furniture in this church and that it wasn't just put up on the Auction Block.
I cannot believe that the City of Lewiston is allowing the Beautiful Lovely Old Stone Church Building to be Torn Down! Why wasn't this building on the National Historical Register? I can't believe this is happening! Why are we allowing to Happen?! We can Save St. Mary's Catholic Church but, we Can't Save a Protest Baptist Church??
What is Lewiston, Coming to?


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It's "int'l."
Your question is too broad. I'm afraid there isn't an easy formula for learning all abbreviations; besides, some words have multiple possible abbreviations. The only way to learn abbreviations is to learn them one by one.
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The Enrollment Management and Marketing Department is responsible for providing the vision and leadership toward advancing the overall growth and reputation of Regis College. These efforts encompass strategic planning, program development, budget oversight, data analysis and institutional coordination of areas focused on the recruitment, retention and promotional efforts of the College at both the undergraduate and graduate education levels.
The Enrollment Management and Marketing Department oversees the Undergraduate Admission, Graduate Admission, Athletics, Financial Aid, Marketing, Publications, Center for Student Services, and Lifelong Learning divisions at Regis.


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Many of our fellow travelers neglected to request early dining and so they were put on a waiting list. The dining room was so full at early seating that, at a table for 10, we barely spoke to the 2 couples at the other end. The noise was such that one had to yell to the person next to him. This was because of the sheer volume of people trying to speak at a normal level. On day 2 service was terrible. The Captain's table was opened for an additional 20 guests and our waitstaff was overburdened. Even the head waiter was serving. We couldn't fault the servers, though. You could see that they were working hard and all pitching in to help. After that one night service was smooth. All of the dining room staff was efficient and courteous.We heard that the late dining was only about 1/2 full, but 8:30 was too late for us to be starting dinner.
The food was good and, as long as you could order as much as you wanted, plentiful. Chops had the best food on board, as it should for an additional $30/person.
Early dining was at 6PM and late at 8:30. The theater times were 8:45 and 10:30. If we went straight to the theater after early dining we had to wait at least 1 hour before the show started. I nearly fell asleep waiting. If you waited until later to go to the theater there were no seats left. We saw one early and one late show only.
The islands were, of course, beautiful. Even when there was rain we were happy to be there.
The worst part of the entire holiday came at the very end. After disembarkation we were to take a shuttle bus back to our hotel to get our car. We were in the parking lot with our luggage around 10:00. The shuttle wasn't allowed to come to us so we had to move all of our stuff across the parking lot. The shuttle finally arrived at 11ish. Surprisingly there was no room in the van for us. We were told by one of her traveling companions that a cruise critics friend, had encouraged some airport bound friends of hers to take our shuttle. We were displaced by people who were not even going to our hotel! We had to wait an extra hour standing in the parking lot surrounded by our luggage before another van could be dispatched to pick us up. We didn't get on the road until after noon. Finally got home about 8:30 that night.


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"Blast From The Past" Softball Game
Community Events
Sat. 11 May, 2013 3:00 pm
Blast From The Past softball game between "Old" Lady Blues and current Lady Blues, Laurel Park, Buena Vista, fund-raiser for American Cancer Society, admission $4 adults, $2 students.
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Oceania Cruises offers several "Signature Sailings," which include voyages exploring culinary, wine, music, health & wellness themes.
Oceania Cruises is renowned for offering an exceptional experience at an incredible value. Book early & save on our most popular itineraries.
There's still time! Take advantage of our limited availability offers, including our 2014 Winter voyages to the Caribbean and South Pacific.
Our ships cater to just 684 pampered guests on Regatta, Nautica and Insignia, and 1,250 privileged guests on Marina and Riviera.
As you travel from one destination to the next, you'll dine on the finest cuisine at sea, spend serene days filled with enriching entertainment and retire each evening to your richly appointed suite or stateroom.
Offering more than ever with no compromise in quality.
Oceania Cruises pioneered extensive overnight stays and late evening departures allowing guests to truly experience each destination to it's fullest.
Save up to 40% off à la carte prices when you purchase the Your World Collection or Unlimited Passport Collection value packages.
For even more in-depth exploration and discovery, we have created a special collection of extended land programs that is without equal.
Oceania Cruises painstakingly selects each world-class hotel for its superb location, ambiance, standards of service, cuisine and amenities.
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Sign in or register for My Oceania.
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Being a member of the Oceania Cruises family allows you to enjoy the most generous rewards in premium cruising.
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Socialize with guests, comment on your favorite stories, posts, images and videos!
If you are already booked with us, please sign in to view and manage your current cruise reservation.
Receive maximum pre-cruise savings by purchasing shore excursions online as early as 180 days and up until 72 hours prior to your sail date.
Discover the hotels and land programs available on your voyage, purchase beverage packages and make your dining reservations.
Visit the Before You Go section to complete your guest registration, request air deviations and learn about insurance, visas and more.
Home > Find a Cruise > Western Mediterranean > Mediterranean Shores > Excursions > Palma de Mallorca > Modernist Art and Architecture in Palma
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À La Carte Excursions | General Information
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Explore Palma's rich contemporary art tradition, including the modernist works of Joan Miró and earlier paintings and sculpture that were inspired by the light and atmosphere of the island.
Begin your gallery walk with a visit to the Casal Solleri, a Baroque building dating from 1763. This stunning building, also known as Can Morell, was acquired by the Palma City Council in 1975 and is used for visiting art exhibitions and cultural events.
Next, you will see the turn-of-the-century Grand Hotel, designed by Catalan Modernist architect Lluis Domenech y Montaner. Then, step inside the Es Baluard Museum, Palma's esteemed Museum of Modern and Contemporary Art. This fascinating facility was built using the Renaissance façade of the ancient San Pedro Fortress, located in the heart of Palma. The building symbolizes the lifestyle of the Mediterranean by including the external spaces as part of the museum enclosure, establishing a natural flow between the indoors and outdoors. It represents a unique architectural and art experience all in one location.
Important Note: Tour does not operate on Sundays or Mondays.
NOTICE: All Oceania Cruises shore excursion fares are listed per person, and are subject to change and availability. Some tours are capacity controlled and may be withdrawn at any time without prior notice. Tour departure times are subject to change so please reference your actual tour ticket for the correct departure time. Minor children under 18 years of age must be accompanied by a an adult parent or guardian on all shore excursions. While Oceania Cruises makes every effort to adhere to the specifics mentioned in each shore excursion description, circumstances may require otherwise. All shore excursion information contained on this website is subject to change without notice at Oceania Cruises' discretion. Oceania Cruises is not responsible or liable for typographical error, omissions or misprints.
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Arsenal Targeting Tiote?
According to the link, Arsenal are preparing a £15 million bid for Cheick Tiote. Obviously, it's entirely probable that this is just another rumor (the same link mentions that Man Utd is unhappy with Rooney and might consider selling him), so I'm taking this report with a large grain of salt. However, in light of Song's transfer, Tiote does make a lot of sense for Arsenal (plus he speaks French!).


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These are commands,
England fight back!
Australia ponder changes!
Pakistan warn against ... !
Sri Lanka crush (whoever)!
These are teams:
(Team) England has a big win.
(Team) Australia selects its team,
(Team) Pakistan is batting
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Nonpublic School Advisory Council (NPSAC) Meeting Minutes
Nonpublic School Advisory Council (NPSAC) 2013-2014 Meeting Calendar
|Representing Non-Public Schools (2.2014)
|Kent Bicknell,
Sant Bani School
19 Ashram Road
Sanbornton, NH 03269
|Lyn Kutzelman, Founder
Hampstead Academy
320 East Road
Hampstead, NH 03841
|Lisa Braiterman,
Chief Financial Officer
Brewster Academy
80 Academy Drive
Wolfeboro, NH 03894
Gregg Magoon, Education Coordinator
|Doug Cummings,
Executive Director
Independent Schools Association of
Northern New England
38 Clark Cove Road
Bowerbank, Maine 04426
|David Parker,
Parker Academy
2 Fiske Road
Concord, NH 03301
|Claire Doody,
Country Village Montessori School
26 Windsor Drive
Amherst, NH 03031
|Stephen Poirot, Chairman
Assistant Head of School
Tilton School
30 School Street
Tilton, NH 03276
Rev. John Fortin
Trudy Wright,
Rick Johnson
|Representing the Public
|William Bennett, Director
Commission on Independent Schools
New England Association of Schools & Colleges (NEASC)
209 Burlington Rd, Ste 201
Bedford, MA 01730
|Linda Johnson Esq.
McLane, Graf, Raulerson, and Middleton, PA
900 Elm Street, Box 326
Manchester, NH 03105
|Representing the Department of Health and Human Services
|Eileen Mullen,
Division of Children, Youth, & Families
129 Pleasant Street
Concord, NH 03301
(603) 271-4343
|Patricia Tilley, Administator
Bureau of Maternal & Child Health
29 Hazen Drive
Concord, NH 03301
(603) 271-4526
|Claire Pstragowski
NH Dept. of Health & Human Services
Sununu Youth Services Center
1056 North River Road
Manchester, NH 03104
(603) 625-5471
|Representing the Department of Education
|Dr. Judith Fillion, Director
Division of Program Support
101 Pleasant Street
Concord, NH 03301
(603) 271-3855
|Deborah Krajcik,
Education Consultant
Bureau of Special Education
101 Pleasant Street
Concord, NH 03301
(603) 271-3301


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Andre S. Watson
Aug 14, 2014
Jose Alberto Miranda
Jul 24, 2014
Juan Sanchez-Rodriguez
Jul 16, 2014
Anthony M. Kay
Jul 10, 2014
Home » News » Crime
Owner of Epping tow company faces drug possession charges
Timothy Castine, of 93 Jenness Road and the owner of Tim & Joni's Towing, was arrested on charges of drug possession, state police Lt. Nicole Armaganian said.
The arrest followed an investigation that began earlier in the day when state police from Troop G arrived to conduct a motor vehicle dealer audit.
During the audit, Armaganian said police "smelled a heavy odor" of what appeared to be marijuana inside the residence on the property where the business is also located.
Police then applied for and were granted warrants to search the property. During the search, which included three police K-9s, Armaganian said police found drugs and drug paraphernalia.
Several state police cruisers were at the property throughout the day, first for the audit and later for the drug investigation that lasted into Monday night.
- Somersworth liquor store robbed - 0
- Judge drops charge in Derry case - 0
- Windham thefts from vehicles on the rise - 0
- Manchester Crime Watch: Tuesday robbers match Saturday robbers' description - 0
- Panel to probe Portsmouth police officer's windfall - 0
- Portsmouth man indicted for alleged Dover burglary spree - 0
- Vt. man indicted for high-speed chase in Rochester last year - 0
- Rochester police release video footage of man in Dos Amigos robbery - 0
- Rochester police ask for public's help to ID restaurant robber - 0
Alleged accomplice of Dover-area burglaries indictedREADER COMMENTS: 0
- Hanover St. building has a buyer - 0
- ISIS beheads NH journalist - 0
- Route 101 plaza unanimously granted two variances for improvements to property - 0
- Mother, daughter, man charged in prostitution case in Nashua - 0
- Rockingham County attorney candidates talk leadership at forum - 0
- Hampton Falls woman charged with striking Rye police officer with her car - 0
- Durham man dies after car door-bike collision - 0
- 73-year-old man drowns in Bow pool - 0
- Manchester stores allowed to reopen after spice outbreak - 0
2nd District GOP candidates spar at FPU debateREADER COMMENTS: 0
ISIS beheads NH journalist
Hanover St. building has a buyer
Market Basket: On the brink again
Pope's call-out Where's the Muslim outrage?
Target: Obamacare
ISIS beheads NH journalist
Market Basket: On the brink again
Judge slams spice search
NH's immigrants: Welcome the ones from Mass.
Pope's call-out Where's the Muslim outrage?
- Mass. Supreme Judicial Court has found upskirt photos taken on a subway aren't illegal. Should such voyeurism be a crime?
- Yes
- 83٪
- No
- 17٪
- Total Votes: 917


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It's been a long day of will they/won't they regarding the Jeremy Stephens vs. Yves Edwards bout at UFC on FX 5: Browne vs. Bigfoot.
Stephens was arrested this morning on an outstanding felony warrant and the bout appeared headed for cancellation. Dana White insisted that the fight WOULD in fact go on despite the arrest and Stephens still being in jail hours before the fight was to take place.
After word circulated from multiple sources that the fight was cancelled, Dana is now tweeting out that the fight will still take place.
The Facebook prelims were cancelled and there isn't exactly time on the standard broadcast for the fight, so it would seem likely that the bout will be after the main event if it does indeed take place.
This is an absolute mess at this point and really it makes no sense to move ahead with the bout.


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More From electrical line
Safety Watch
Posted by Brooke Wisdom on Jun 01, 2011
Electrical problems Recognize, evaluate and control hazards to stay safe By Equipment World Staff The accident: A four-man crew was adding space to ...
Do you want some tips to stay safe on the job site?
Equipment World has created an entire section devoted to safety.
Here are the most recent tips we've posted:
Hauling headaches: Know your load limits when trailering equipment
One-man machines: The operator should be the only person on a wheel loader


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Salem, NH — Of Rockport NH, passed on Nov. 18 , 2012, 70 yrs. Mother of two beloved children: Marvin Clyde Gruelle and Jon Robert Gruelle. She is survived by siblings: Gunnar Johnson, Elly-Ann Johnson, and Roy Johnson, and 6 grandchildren; Jordan Gruelle, Gunnar Gruelle, Margaret Gruelle, Vivian Gruelle, Winston Gruelle, and Truman Gruelle.
She was born June 17th, 1942 in Rockport, MA. She worked for Eastern Airlines as a flight attendant for many years. When her children became school age she started working full-time as the school bus driver and drove the big yellow bus for almost 40 years. She recently retired at the age of 70 this past spring. Driving the kids to school every day and taking them on their numerous trips gave her great joy. She also enjoyed spending time with her siblings, children and grandchildren.
ARRANGEMENTS: Honoring her wishes, there will be no funeral service. Condolences can be made to Marvin Gruelle firstname.lastname@example.com and Jon Gruelle email@example.com.
In lieu of flowers, donations can be made to the American Cancer Society, P.O. Box 22718, Oklahoma City, OK 73123-1718.


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YOUNGSTOWN, Ohio - Able-bodied Ohioans without children are now required to work, or they face losing their food stamps.
For years, Ohio waived a mandate requiring able-bodied individuals without children to work, volunteer or attend job training at least 20 hours per week in order to receive their food stamps.
In late 2013, that waiver expired and has not been renewed for some Ohio counties, including Mahoning where there are about 4,500 individuals that could be affected.
"They come in to be assessed and then we refer them to some place where they can volunteer and continue receiving the benefits," said Gwendolyn Graves with Jobs and Family Services.
So far, the county agency has tried to meet with about 1,500 individuals, but the majority are not coming for their assessment. Therefore, they do not receive the food stamps, which for some is $200 per month.
"If they don't come in for it evidently there is no need for it, but those who need that assistance will come in," said Graves. "You're talking a ratio of 60-70% that are 'no show.' That's a lot of individuals who just choose to not come in."
Despite the "no shows," Graves believes the work mandate still needs to be waived in Mahoning County.
"Here in Youngstown regardless of what the unemployment rate looks like, there are a lot of individuals that are unemployed and there's no jobs. There are not enough jobs here," said Graves.
The Second Harvest Food Bank says at this point, it's too soon to tell if they will see an up-tick in need due to the work requirement.
They expect to see the impact, if any, by early spring.


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Danny Shafer, acoustic
- When: Friday, February 8, 2013, 9:30 p.m.
- Where: Carl's Tavern, Steamboat Springs
- Cost: Free
- Age limit: 21+
- Categories: Blues, Singer/songwriter
Danny Shafer — Carl's Tavern, 9:30 p.m.
Boulder-based singer-songwriter plays Americana and blues. FREE. Call 970-761-2060. Seventh and Yampa streets.
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Effective Employee Relations CO251
Creating and sustaining a positive work environment is a core responsibility of HR. Through proactive initiatives, HR practitioners can guide managers and work with employees on addressing employee issues and concerns. This highly interactive workshop delivers a practice-based approach for managing employee relations within your organization. Applying realistic and common workplace challenges, this two-day workshop will provide you with the knowledge and skills to:
- Incorporate employee relations competencies and techniques
- Identify and learn how to address employee concerns
- Practice coaching, counseling, and progressive discipline strategies
- Demonstrate effective communication
Key Topics
- Understanding the role of employee relations as it applies to an HR Professional
- Providing guidance and support about organizational policies and practices
- Developing constructive and cooperative working relationships with managers and employees
- Working strategically with managers to problem-solve and address employee relations issues
- Collaborating and consulting with colleagues and other areas of expertise, including legal
- Conducting effective conversations
- Recognizing different working styles and preferences
- Guiding managers through the coaching, counseling and progressive discipline processes
- Partnering on Performance Improvement Plans and Terminations
- Managing complex employee issues and complaints
- Promoting and maintaining positive employee relations
Who Will Benefit
HR professionals who have recently acquired responsibility for employee relations in their organizations. Also, HR professionals who are new to the employee relations area, have had limited employee relations responsibilities, or have assumed this function in addition to other duties.
Susan W. Brecher, Esq., Director of Employee Relations, Legal, EEO and Diversity Programs in Human Capital Development at Cornell University, ILR. She currently manages learning services in Legal, Employee Relations, and EEO, including developing, designing and facilitating programs. In addition, Ms. Brecher partners with private, public, and non-profit organizations on customized training programs. During her tenure at Cornell, Ms. Brecher served as a Director of Statewide Management Programs as well as oversight of all aspects of the EEO, Labor Relations, Human Resources, Management Development and Online Learning programs. Ms. Brecher teaches in a graduate level Human Resources Program and advises, consults, coaches, handles all aspects of employment law, employee relations, internal investigations, dispute resolution issues and mediates, facilitates and conducts fact-findings. She worked at the law firm Skadden, Arps, ABC and NBC and holds a B.A. summa cum laude, Phi Beta Kappa, from Union College and a J.D. from Case Western Reserve University, where she was on the Law Review.
Lisa Csencsits, Associate Director in Human Capital Development at Cornell University, ILR, is responsible for the design, development and delivery of customized learning and capability development programs. Ms. Csencsits, as an Organizational Development Practitioner, leverages her experience working with large privately and publicly held companies, as well as her research and educational expertise to provide programs grounded in theory with practical solutions to enhance participant learning and professional development. Ms. Csencsits's expertise includes implementing effective, innovative and sustainable interventions to enhance organizational performance, individual and team development. Lisa's work has included establishing talent management processes for greater efficiency and results, delivering learning programs aimed at building strategic leadership, working alongside management and leaders to identify and define the necessary capabilities needed to perform effectively in their functions and creating unique career development opportunities to support both organizational needs and employee growth. Over the years, Lisa has also been actively involved in partnering to present and publish research in the field of Industrial/Organizational Psychology. Lisa holds a B.A. In Psychology from Adelphi University and a M.A. in Industrial/Organizational Psychology from Hofstra University.
Shelley M. Greenwald, Esq., Principal, Shelley M. Greenwald, Esq., specializing in the field of employment practices and litigation. Ms. Greenwald advises, counsels, trains, and handles all aspects of employment law litigation. Formerly, she was in-house counsel at NBC and has appeared on CourtTV and CNBC.


text: 1 Hurry! Last few MANFROTTO MK394-PQ Photo Kit QR Tripod Suitable for compact & compact system & DSLR cameras Mount size: 1/4" Max. height: 1.44 m Maximum load: 3.5 kg Home delivery unavailable Collect in store £17.97 was £69.99 Save £52.02 Product details If you need support for both still photography and video recording, then the Manfrotto MK394-PQ Photo Kit QR Tripod is for you. The Manfrotto MK394-PQ with an integrated compact photo head and a quick camera attachment providing fast, multi-angle movements will allow superb photography solutions so you can get the perfect shot.Thanks to its aluminium construction, the Manfrotto MK394-PQ Photo Kit QR Tripod is lightweight, sturdy and won't let you down. It's also incredibly easy to transport... Find out more More info


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One woman is auctioning off her rare 65-year-old Lincoln to help out a child in need.
5-year-old Ryder Page was born with cerebral palsy and also has a very rare form of muscular dystrophy; one that only affects 1 in 1 million people.
"Some people, when I tell them about my son, they say I'm sorry for you and I tell them I'm not sorry at all. He is one of the most incredible people I've ever known in my life and I'm honored that God blessed us with such an amazing child," said Kiralee Page, Ryder's mother.
Saturday a special car is going up on the auction block at Barrett-Jackson, and its proceeds are helping Ryder and other children like him.
"Ryder, even at 5-years-old, is a classic car nut, so for him to be here is a thrill of a lifetime for us," said Greg Page, Ryder's father. "It's such a blessing to give a little bit back and hopefully another kid can have the same opportunities to have a normal life as Ryder has."
It's a 1957 Continental Mark 11, Elvis had one of only 44 that were manufactured. Only two were in green and we have one of those two," said Karen Malta, auctioned car owner.
Karen met Ryder and his mother at the salon and she instantly fell in love with the family.
She and her husband decided to auction off their rare car to help Ryder and others like him.
"It's a love car, it's a 'helping pay it forward' car, it can bless a lot of people. It's gonna do a lot more good going through Barrett-Jackson than at home. We just want to make a difference," said Malta.
A portion of the proceeds from the auction will go the Barrow Neurological Institute at Phoenix Children's Hospital.
Karen and John Malta are hoping that the proceeds will make a huge difference in children's lives, just as Ryder has made a difference in theirs.
"Ryder's a hero. He's positive, he's happy and so are his parents and his little sister. They're just an inspiration to us and all people who have kids at children's hospital," said Malta. "He has just brought light into so many peoples lives, we're so touched by him every day."
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Friday, February 15, 2008
Kevin Regan posts career-high 52 saves for Wildcats
Box Score - Text Box - Game Sheet
PROVIDENCE, R.I. - The 14th-ranked Providence College men's hockey team and No. 4 New Hampshire played to a 1-1 overtime tie Friday night in a Hockey East game at Schneider Arena. The Friars outshot the Wildcats, 53-29, but UNH goalie Kevin Regan made a career high 52 saves.
The Wildcats took advantage of their first power-play opportunity to take a 1-0 lead. PC goalie Tyler Sims (Fort Wayne, Ind.) made a save on a shot by Brad Flaishans, but Danny Dries pounced on the rebound and scored his seventh goal of the season. The Friars held a 20-11 shot advantage in the first period, but were unable to put the puck past Regan.
However, the Friars broke through at 13:39 of the second period as sophomore John Cavanagh (Warwick, R.I.) tallied his fifth goal of the season. Junior John Mori (Westport, Conn.) and freshman Ian O'Connor (Londonderry, N.H.) cycled the puck down the right wing before O'Connor played the puck to the slot to John Cavanagh who fired a high wrist shot by Regan.
John Cavanagh had chance to give PC the lead with 2:39 left in the third period as he was on a partial breakaway, but Regan turned his shot aside. In overtime, Mike Radja also had an opportunity to score the winner when he had a clean breakaway, but his shot went wide with 26 seconds remaining in the extra session. Sims finished with 28 saves for the Friars.
The two teams will close out the home-and-home series tomorrow night at the Whittemore Center in Durham, N.H.
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~ Le Me ~ Last.fm ~ Instagram ~ My Second Blog ~ My gifs
If this is all that I remember, can I ever trust myself?
Dunja, 22, Serbia.
Studying Scandinavian languages and culture in Belgrade (Swedish being my main). Interested in all that is metal, from all the subgenres to the lifestyle itself [melodeath, folk and heavy being the most important]. Geography, languages, history, paganism (Nordic and Slavic mostly) follow - the stranger, the farther, the better. And the rest - cats, books, long haired guys, purple, fetishes for leather and high heels, alcohol... and who know what else, you know what they say about Aquarians - they keep tripping they are unique and peculiar, and I am no exception whatsoever.
Occasionally spamming with Vikings, Game of Thrones/ASOIAF, The Walking Dead, True Blood, Band of Brothers, American Horror Story, Hannibal etc, so be warned.
52 notes
18th August 2011 @ 01:54am


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Bandit Lites is working with this year's Country Music Awards Horizon winner and Female Vocalist of the Year, Carrie Underwood. Lighting designer, Seth Jackson, and Bandit's lighting director, Drew Gnagey, collaborated with David "Fuji" Convertino to program and direct the show.
Underwood is out on her first tour, supporting her multi-platinum album, Some Hearts. The tour includes headline dates as well as special guest slots on tours such as Kenny Chesney and Brad Paisley. Seth Jackson and crew put together a simple system that is able to merge into whatever house or headline artist's system that they might encounter.
The show carries a riser package and a swaged velour backdrop. Upstage, on the floor, are Martin MAC 2000s. Built into the set are six towers that each have a Vari*Lite VL3000 Spot mounted to the top.
"The 2ks upstage give us the perfect floor light for one song, and then they can open up their zoom and fill the drape with color for another," explains Jackson. "The VL3ks are also a perfect fit. With the zoom abilities of the light, those six lights, only ten feet off the ground, are able to cover the entire performance area."
The show was built with a grandMA console, and Gnagey, is traveling with a Grand MA Lite. Jackson and team programmed the show so that it not only included the lights they are traveling with, but also an overhead rig that matches their touring rider.
"No matter what types of lights we run into, Drew is able to adjust the console to respond to the cues the same, giving the show a great deal of consistency in look, even though the physical hardware may be quite different from day to day," explains Jackson.
Bandit vice president, Michael Golden adds, "Carrie Underwood is an incredible talent and with the production support of production manager, Chris Coffie and tour manager, Keith Dean, I believe she will be a touring force for many years to come."Bandit Lites Lighting Carrie underwood concert Tour Mac Martin


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Our Services
When it comes to local business advertising, there are no cookie-cutter solutions. Your business is unique, and your marketing needs can vary depending on what you do, where you're located, and who your customers are.
At Dex Media, it's our business to provide your local business with the marketing solutions it needs to succeed.
Online Business Listings
Dex Media's online business listings will get your message in front of consumers who are ready to buy, and will ensure that your business info is easy to find.
You never get a second chance to make a first impression, so make sure you dazzle your customers from the start with a professional and attractive website for your business.
Search Engine Marketing
With so many businesses advertising online these days, you need an edge to set yourself apart from the competition. Our SEM services can help your website rank higher in organic and paid search results, which means more clicks and more leads for your business.
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Listings/Reputation Management
Managing your online reputation has never been easier! Our Digital Presence Management solution makes it simple to track your online listings, view your customer reviews, and keep tabs on your social media buzz.
Social Media Marketing
If you're looking for a way to build trust and loyalty with your customers while promoting your brand, social media is definitely the way to go. Dex Media can help you connect with your customers and build them into a community of loyal fans.
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Text message marketing is a great way for local businesses to reach out to mobile shoppers. Whether you're looking to motivate your customers with special offers or reward them for their loyalty, Dex Media has a solution that's right for your business.
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Online video advertising is an excellent way to reach out to potential customers and forge a deeper connection with them. Video ads are convenient and engaging, which makes them the perfect medium for pitching your products or simply showcasing your business.
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Traditional print media is still a viable means for reaching out and connecting with potential customers. Dex Media's print advertising solutions can be used as standalone marketing strategies or to enhance your online marketing campaign.
Performance Tracking
Our call tracking and reporting services take the guesswork out of marketing your business. We capture and track every call your ads generate, so you can tell at a glance which parts of your marketing campaign are working and which might need a little tweaking.


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A boy calls 911 from inside a carjacked vehicle with four other kids.
MOBILE, Ala. (AP) - Mobile County Sheriff's officials say a teen who escaped from a courtroom and eluded authorities has been recaptured.
AL.com (http://bit.ly/X8NzwQ ) reports 18-year-old Deven Lane Stephens escaped a Mobile courtroom, ran from several officers and bondsmen and ran downtown Wednesday morning after his bail had been revoked. The man had not been placed in handcuffs.
Stephens was arrested on charges of manufacturing and trafficking methamphetamine and was also charged with burglary.
Police say they found the man hiding under a house in Chickasaw, just north of Mobile.
Information from: Press-Register, http://www.al.com/press-register/
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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It's very strained- it would be far more natural to use a conjunction like 'because', 'as' or 'since'. I can't say it's wrong, and the usage does exist, but it really doesn't work in your examples, IMO.
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Charming Updated Cabin, Newly Remodeled, Quiet, Hot Tub, Near Heavenly in South Lake Tahoe
- bedrooms 4
- baths 2
- sleeps 10
- pool no
- hot tub yes
- pets considered no
- type House
rates (USD)
/ night
$ 1,225 - $ 1,680 / week
vacation rental description
Welcome to our 'Cozy Cabin'
We fell in love with this house the minute we saw it, and we know you will too! This place truly defines the 'Tahoe Experience'. Located in the quiet, lovely Black Bart neighborhood, on a spacious, wooded lot, with a gorgeous meadow and stream across the way, you truly feel like you are away from it all. However, hop right on Pioneer Trail and you will be at Heavenly Ski Resort, the casinos, or the beach in just 5-10 minutes. Bijou Park with a skate park, playground, and fields are also within walking distance or a short bike ride away.
The charming house is located at the end of a culdesac, with no neighbors on either side. It is tucked away from the street, so it feels like you are secluded. Have kids? So do we. They will love running around and exploring the wooded lot, with NO traffic going by. We know our kids do!
Our cabin is newly renovated, top to bottom, with gorgeous wood floors, pine doors and trim, open, beautiful vaulted wood ceiling, granite counter-tops, and travertine tile.
Fast WiFi (N600 router) that has a strong signal throughout the house and will handle multiple devices with ease.
Keyless entry (4 digit code) makes it very convenient to come and go without having to carry a key. Especially convenient for larger groups since there is no need to share keys.
Downstairs, you will walk into a large open foyer, with the two bedrooms, a laundry room with brand new full size washer/dryer, and a mud room to keep all those jackets and snow boots out of the way.
The master bedroom, on the first floor, has it's own bathroom with a newly tiled shower, tub and granite topped vanity. It also has a cozy, romantic fireplace, ceiling fan, two closets, flatscreen TV, and French doors leading out onto the porch. You will love the queen size bed, with a brand new luxury plush mattress, soft pillows, and Pottery Barn bedding.
Also downstairs, the 'bunk room' has two sets of bunk beds, a flatscreen TV, Playstation 3 (with games), and lots of games for the kids to enjoy. It's a great place for the kids to hang out and have fun.
Both downstairs bedrooms are equipped with ceiling fans. The home does not have air conditioning (as most Tahoe homes do not), however even in the summer the the nights are very cool and letting in the mountain air will be enough to cool you off.
Upstairs, you will be wowed by a large, open great room with brand new leather couches and a cozy floor to ceiling brick fireplace . A brand new 55' LG smart LCD TV (with internet access, Netflix, Hulu, etc), Blu-Ray DVD player, and a soundbar for rich theater sound. Want to listen to music? Just connect your mobile device (smartphone, iPOD, etc) to the soundbar for great sound.
The dining room table seats 8 and you will love enjoying the gorgeous view of Mt. Tallac right out the large picture window.
Adjacent to the open great room is the kitchen, with granite counter-tops, brand new appliances and a breakfast nook with seating for 4. The kitchen is fully stocked with cookware, dishes, coffee maker, toaster, crock pot, blender, just about anything you need! We also have coffee filters, coffee creamer, olive oil, aluminium foil, plastic wrap, and spices on hand to help save money on your grocery bill.
Just off the great room is a huge deck with a beautiful view of the meadow out front. The deck has a patio table for outdoor dining, chaise lounges, brand new BBQ, and a steaming hot tub ready to go.
Upstairs there are also two more bedrooms, each with a queen size bed, and one more bathroom. We splurged on super comfortable Sealy pillow top mattresses, soft pillows, and Pottery Barn bedding....so you are sure to have a good night's sleep every night.
We also just installed a brand new tankless water heater that never runs out of hot water....so your group can enjoy unlimited hot showers without ever worrying about running out of hot water.
There is also beach gear (beach chairs, umbrella, and a cooler) that is available for guest use in the summer months.
Booking: Your reservation will be confirmed when the first payment and signed rental agreement have been received. Minimum age for renters/groups of adults is 25.
vacation rental location
property availability
- dates with deals
- unavailable dates
Last modified on 08-19-2014 at 11:26 AM.
email owner view full calendar
Jamie Loosbrock 8583956392
house rental amenities
Property Type
- house
- floor area 1700 sq. ft.
- guests provide their own meals
Location Type
mountain view
- Breathtaking views of the Mt. Tallac from the balcony deck and family room.
- mountain view
- adventure
- away from it all
- family
- romantic
- sports & activities
- tourist attractions
- internet
- fireplace
- wood stove
- heating
- linens provided
- towels provided
- washing machine
- clothes dryer
- parking
- living room
- hair dryer
- iron & board
- kitchen
- refrigerator
- stove
- oven
- microwave
- dishwasher
- dishes & utensils
- pantry items
- coffee maker
- toaster
- dining area
Pool / Spa
- hot tub
- Bathrooms
- 2 bathrooms
- bathroom 1: toilet, combination tub/shower
- bathroom 2: toilet, shower
- Bedrooms
- 4 bedrooms, sleeps 10, beds for 10
- bedroom 1: 1 queen
- bedroom 2: 1 queen
- bedroom 3: 1 queen
- bedroom 4: 2 bunk bed, Two sets of bunk beds - 4 beds total
- television
- satellite / cable
- dvd player
- video library
- video games
- games
- toys
- game room
- stereo
- outdoor grill
- deck / patio
- balcony
- minimum age limit for renters
- children welcome
- non smoking only
- wheelchair inaccessible
- pets not allowed
activities and attractions in South Lake Tahoe Lake Tahoe Area
- marina
- playground
- restaurants
- cinemas
Leisure Activities
- beachcombing
- gambling casinos
- outlet shopping
- paddle boating
- scenic drives
- walking
- shopping
- sight seeing
- boating
- sledding
- wildlife viewing
- horseback riding
- antiquing
- horseshoes
Sports & Adventure Activities
- fly fishing
- freshwater fishing
- ice skating
- mountain climbing
- pier fishing
- water tubing
- golf
- kayaking
- sailing
- water skiing
- parasailing
- jet skiing
- swimming
- cycling
- mountain biking
- cross country skiing
- skiing
- snowboarding
- snowmobiling
- hiking
- fishing
accepted payment methods
Prior to paying a reservation deposit, always verify payment instructions by calling the phone number displayed on this listing page. By contacting the owner directly and paying by an approved method - credit card, paypal, check or bank transfer - your reservation payment will be protected up to $1,000.Learn more in our Security Center


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*Today's post was sponsored by Fruitshoot. All opinions and lunch ideas are my own.
I have this special treat I love to do for my girls.
I don't do it as often as I should, but then it's not a treat, is it?
I like to make bento-style lunches for them.
I create sushi rolls out of sandwhiches, or just the meat and cheese. I add in vegetables and fruits, and the best part? They are so excited by the fun take on the food, that they happily eat all the healthy food I can pack into the meal…and even better? They eat more than they would if I just offered them a sandwich.
Today we're heading out on an adventure for our first day of spring break. For my new job (more on that later), we're heading out to a farm to check out the baby animals. The girls are so excited, but I'm going to surprise them with their favorite kind of lunches.
I've got all their favorites in there. Tomatoes, cheese, carrots, bologna, craisins, strawberry's, yogurt covered raisins, and hard boiled eggs. I rolled the bologna and cheese into sushi-like rolls, and then made the [amazon_link id="B00CDPNA70" target="_blank" container="" container_class="" ]kitten and panda faces[/amazon_link] out of them, too. I went with a "round" theme with the carrots to match the rest of the fruits, and mixed all the fruits, dried and fresh, together for them.
All of that is topped off with their (and my) newest favorite drink. Apple Fruitshooter's!! They love the tasty drink, and that they can open them themselves (that whole independent streak they've got going) – and I love that handy little note at the top of the label "No Sugar Added".
It's a fun and easy way for us to all get what we want…and it's a great way to get a drink into their lunches.
So how do you like to fun-up your kids lunches?
*Today's post was sponsored by Fruitshoot. All opinions and lunch ideas are my own.


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The St. Louis Rams will take on the New Orleans Saints without starting quarterback Sam Bradford who will miss the second game in a row dealing with an ankle injury. Bradford tried to give it a go this week in practice again, but will give way to back up A.J. Feeley. Bradford is dealing with a high ankle sprain, which often take at least three weeks to heal. You should expect Bradford to give it a go again next week in practice.
Even if Bradford were playing, the Rams passing offense has been dreadful this season. The transition to Josh McDaniels offense hasn't gone smoothly at all. The addition of wide receiver Brandon Lloyd should help with Bradford comes back, but there is still a lot of work to do.
For more on the Rams head over to our Rams blog Turf Show Times. For more information on Week 8 in the NFL and fantasy news, follow this StorySteam.


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Kidderminster CAMRA members branch out (From Kidderminster Shuttle)
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Kidderminster CAMRA members branch out
6:20am Wednesday 19th February 2014 in News
MEMBERS of Kidderminster's CAMRA sub-branch have voted to become a branch in their own right.
Steady recruitment over the past year was boosted by a surge in membership at last year's Kidderminster Beer Festival. Membership has risen from 190 to 270 and members are confident that 300 will be achieved at this year's beer festival, if not before.
The decision to set up the new branch was taken during its annual meeting at Severn Valley Railway in Kidderminster.
Previously, Kidderminster was a sub-branch of CAMRA's Redditch and Bromsgrove Branch. The sub-branch's ability to organise a successful beer festival was recognised regionally and nationally. Regional director Gary Timmins expressed support for its new status.
Officers have been voted into place and the newly-formed Wyre Forest Branch of CAMRA will soon have a new logo and be in charge of its own finances.
Meanwhile, work is advanced on this year's beer festival at Kidderminster Town Hall, from May 22 to 24 inclusive. As well as local ales, ciders, perries and wine, this year it will feature a range of beers from coastal breweries.
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DescriptionA snake eye follows your every move in this live wallpaper.
The photo-realistic eye follows your every move. It responds to your phone orientation as well as to you touching the screen. You can optionally disable automatic tracking.
This is a Live Wallpaper you have to "see" to believe!
* Live wallpapers are set similar to a background. Search for "Set Live Wallpaper" + your phone
* No support for landscape orientation.


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Public Meeting Requirements Relating to Accessibility
The subsequent information is in compliance with the Americans with Disabilities Act (ADA); the following will be made available upon request:
- American sign language interpreters
- A sound enhancement system
- An agenda of meeting available in alternative formats and
- A reader during the meeting
To arrange for the above services, please contact Megan Bourne at 415.750.3669 at least two working days prior to a meeting. A late request will be honored if possible. Minutes of the meeting will be made in alternative formats upon request. Meeting agendas are available on the City of San Francisco's SFGov.org website.
In order to assist the City's efforts to accommodate persons with severe allergies, environmental illnesses, multiple chemical sensitivity, or related disabilities, those attending public meetings are reminded that others may be sensitive to various chemical-based products. Please help the City to accommodate these individuals.
For information about Muni's accessible services, call 415.923.6142.
Accessible seating for persons with disabilities (including those using wheelchairs) will be available. For Telecommunication Device for the Deaf (TDD), the Museums use the California Relay Service.
2012 Board of Trustees Meetings 2014 Board of Trustees Meetings
|Thursday, January 23
|3 pm
Piazzoni Murals Room, de Young
|Thursday, April 3
|3 pm
Board Room, Legion of Honor
Thursday, June 5
3 pm
Piazzoni Murals Room, de Young
Thursday, October 16
3 pm
Board Room, Legion of Honor
2014 Executive Committee Meetings
Wednesday, May 7*- CANCELLED as of 4/28/2014
Thursday, September 18
|3 pm
|Piazzoni Murals Room, de Young
Tuesday, December 9
|3 pm
|Board Room, Legion of Honor
*Note: The date of this meeting was changed at the January Board Meeting from March 5 to May 7. Please note the time and location also changed.
Meeting Agendas
FAMSF Board of Trustees meeting agendas are available on SFGov.org, the Web site of the City of San Francisco


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UC Application opens Aug. 1st.UC App filing period is Nov. 1st to 30th.start your UC Transfer Planner anytimeask us how.
We provide friendly, highly informed counseling and advising to NVC students planning to transfer to a four-yearuniversity. Our special focus is helping students transfer atthe Junior level to the college of their choice.
Spring Hours Contact Info Monday, Wednesday, Thursday, 9 to 5 p.m. 707.256.7333 Tuesday, 9 to 7 p.m. Room 1335Friday, 9 to Noon Our Resources Plan Your Transfer Now! -Counseling and advising 1. Decide on transfer major -Transfer education plans 2. Choose universities you are interested in -Visiting university representatives applying to that offer your major -Transfer Admission Guarantees 3. Know the criteria for acceptance into those -Concurrent Enrollment universities and the major: -Transfer Advocate Program a. # of transferable units -Web access to transfer information b. Major prerequisite courses -Transfer Day c. General Education -Van and bus tours of local colleges d. Grade Point Average needed to be competitive - Transfer Student Celebration 4. Will you need to Audition or submit a portfolio, have - Workshops and Class Presentations major related job/volunteer experience?
Our StaffJose Hurtado, Counselor & Career/Transfer CoordinatorKristine Hannum, Secretary 1Mark Martin, Student Service Specialist
Talk to US follow the link, in red, to let us know what you think.
Napa Valley College • 2277 Napa-Vallejo Highway • Napa, CA 94558 • (707) 256-7000 • (800) 826-1077
Upper Valley Campus • 1088 College Avenue • St. Helena, CA 94574 • (707) 967-2900
Accredited by The Accrediting Commission for Community and Junior Colleges
Designated Hispanic Serving Institution (HSI), US Department of Education


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Welcome to the fantasy world of Glorantha at Glorantha.com, the place on the web to experience the richness and wonder of Greg Stafford's Glorantha. This is nexus of Gloranthan activities regardless of whatever rules system you use.
Welcome to the fantasy world of Glorantha at Glorantha.com, the place on the web to experience the richness and wonder of Greg Stafford's Glorantha. This is nexus of Gloranthan activities regardless of whatever rules system you use.
You've heard us talk about all the great things that happened at Gen Con. But alas, there was a dark lining lurking within our silver clouds: several people at Moon Design and Fire Opal got sick, and are in no condition to launch a Kickstarter this week. Even mighty Neil the Indefatigable seems a bit on the defatigable side.
So we're delaying the start of our 13th Age in Glorantha Kickstarter until our key people are healthy enough to contribute to the effort. We have a few things that need to be finished before we launch, and we're hoping that rest, lots of liquids, and visits to the doctor pay off and we'll be able to launch in a week. We'll keep you posted!
In the meantime, enjoy this Gen Con seminar on 13th Age adventure design with Rob Heinsoo, ASH LAW, Gareth Ryder-Hanrahan and Philippe-Antoine Ménard (aka the Chatty DM).
Moon Design Publications is excited to announce that we have partnered Jeff Richard up with Rob Heinsoo and Jonathan Tweet of Fire Opal Media to produce a Glorantha core supplement for 13th Age. The book 13th Age in Glorantha will be launched via a Kickstarter starting on August 27, 2014.
13th Age is the Ennie-nominated, OGL d20-rolling game that's built to help your campaign generate great stories. It is targeted towards experienced games masters and players of all levels of roll-playing experience. 13th Age offers straightforward rules that promote dramatic, exciting combats.
As a supplement, 13th Age in Glorantha does not repeat the rules presented in the 13th Age core rulebook. Instead, the classes, monsters, and rules appearing in 13th Age in Glorantha will enable you to use the 13th Age rules to experience the mythic fantasy of Greg Stafford's Glorantha.
13th Age in Glorantha is myth-centered and set during the Hero Wars. Heroquesting to set things right, or to at least set things into a place that isn't infested with Chaos monstrosities, is the focus of the default campaign style. Glorantha veterans will have no trouble adapting the heroquesting tools to their own campaign styles. Newcomers to Glorantha will get to learn about the world by playing through its foundational myths.
Come learn more and get ready to join the Kickstarter at www.13thageinglorantha.com!
We have a new discussion area in the forums for it as well.
Moon Design Publications is very proud to announce that the first three pages of the Prince of Sartar webcomic by Kalin Kadiev and Jeff Richard is now up at http://www.princeofsartar.com.
Prince of Sartar will be a regular feature, telling the story of the Hero Wars, myths, and exploring Glorantha through Argrash, Samastina, Jar-eel the Razoress, Harrek the Berserk, and many more! You know the drill – check it out!
Here's that link again: http://www.princeofsartar.com.
If you want to discuss it, we have a new area in the forums for it as well.
Come join Moon Design this August 14th through the 17th at GenCon in Indianapolis. The whole team will be there:
Rick Meints, President, Moon Design Publications
Plus special guests: Ian Cooper, Pete Nash, Michael O'Brien (MOB), and Lawrence Whitaker! And special special guest: SANDY PETERSEN!
We've got a ton of events going on, including the following seminars and panels:
Plus we will be making some big announcements, which you will hear about very soon! Some come and visit us! We'll have copies of the Guide to Glorantha, Sartar, Pavis, Sartar Companion, maps, and more for sale as well. MOB will have the Zero Edition of our newest card game – UNFAMY! – and you'll have lots of chances to play it with its designer!
You can now buy the Guide to Glorantha and the Argan Argar Atlas directly from our store! PDFs are now immediately available, hardcopies will ship after the Kickstarter and Pre-Orders are fulfilled (which is starting now). There are a limited number of copies of the Guide to Glorantha book, so get yours while it is still available. The Guide will also be available to buy at GenCon and EssenSpiel, so you can save on shipping if you get it there. Curious what this book looks like? Check it out here:
It has come to our notice that the legend for the Argan Argan Atlas can be difficult to read without retina display or a large monitor (it looked fine on our iPads, MacBooks, and big screen monitors, so we didn't catch the problem in our review). The legend is also printed as a full page in the Guide to Glorantha, where it is very readable. But why should you have to open the Guide to read the legend for the AAA? We say, you shouldn't have to! Instead here's the legend for the Argan Argar Atlas as a nice, easily readable jpg:
We are about to throw the big switch on the wall of Moon Design HQ that will open the floodgates of PDF downloads. Yep, the PDFs are ready to get downloaded into your eagerly awaiting (and thankfully patient, hands).
Very shortly registered Kickstarter backers will be receiving an email from us with download instructions and such. We are sending these out in random small batches to backers first, so you may get the email a little later or earlier than one of your Kickstarter Colleagues. If you have not registered on Glorantha.com you will not get the email. We can send a download link shortly after you do register. Our digital dwarves have been slaving away to make sure it will be an efficient experience, but there is always the possibility that gremlins and nilmergs may test us along the way.
A few things we ask you to keep in mind as you begin downloading:
Once we have sent everything out to the registered Kickstarter backers, we can start the process of getting the download links to those who preordered the Guide!
As always, thank you for your support.
For more information, please go to: https://www.kickstarter.com/projects/224590870/the-guide-to-glorantha/posts/906955
Here it is – the Guide to Glorantha. A magical tome detailing the fantastic mythic realm of Glorantha. Six kilos of Gloranthan Gold. Perhaps this video can describe it better than words:
|Copyright © 2014 Moon Design Publications - All Rights Reserved. Glorantha is a Trademark ® of Moon Design Publications | Glorantha | Legal Information


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Press the play button to hear the latest news from THE REGION.
Crown Point, Indiana
- Mayor Uran and the City of Crown Point will join the First United Methodist Church at 7:30am and 7 pm for a 9/11 Remembrance Ceremony. Mayor Uran will speak at the 730am ceremony located at 352 S Main St. For more information please contact First United Methodist Church at 663-1515
Gary, Indiana
-The City of Gary will host a 9/11 ceremony on the steps of City Hall at 8:00 am to remember and pay tribute to those who lost their lives during the terrorist attacks in 2001. The public is invited to attend.
Hobart, Indiana
The city has scheduled an Always remember Memorial Service from 7:30 to 8 pm Tuesday at Festival Park, 111 E. Ridge Road. The Service, in remembrance of 9/11, is being sponsored by the city, Hobart Fire and Police departments, the American Legion and the Veterans of Foreign Wars. The events will include speakers, presentation of wreaths, volley fire salutes and balloon release. The Marine Corps League, Ladies Auxiliary and ROTC will also take part
Lake Station, Indiana
-Please join us at Lake Station City Hall at 9:00 am on September 11th, 2012 for the eleventh anniversary of 9/11. a brief ceremony will be held with Mayor Keith Soderquist, who will speak about those who perished and carry on the memory of 9/11. Event highlights include a Moment of Silence, Opening Prayer, Raising of the Flag, River Forest Band, singer/song writer Ron Crist, and Polk Elementary Kid will sing.
Merrillville, Indiana
-The Merrillville Town Council has scheduled a 9/11 memorial ceremony Tuesday evening at Town Hall, 7820 Broadway starting 6:30 pm. The program will include a candlelight vigil, the Merrillville police department's honor guard, the Merrillville High School choir along with the schools orchestra are expected to participate, through out the service police and firefighters prayers will be said.
South Haven, Indiana
-American Legion Post 502 in South Haven presents "Patriot Day Remembrance" on Tuesday September 11th at 7:00 pm in the Pavilion. The event will open with Sheriff David Lain singing the National Anthem, Post 502 Honor Guard to Post Colors, Portage Township Trustee Brandon Clancy will also attend, along with South Haven Fire Department doing Ringing of the Fives, and Cerie Copes of Porter Co. Pilots Association who provides packages to the troops. 429 W. 750 N. Valparaiso, In for more info please contact the Post at 219-759-2121
Valparaiso, Indiana
-Tuesday, September 11, 2012 the the 11th anniversary memorial of 9/11, the American Legion Post 94, at 4 E. Monroe, (across from Von Toble Hardware) will have a memorial service to remember, honor and pray for the true American Hero's who perished that day, along with family, friends, and loved one's left behind on the day infamy that changed our lives. Public is welcomed, services start at 11 am. Please come and honor our hero's with us. Any questions contact American Legion Post 94 at 219-462-4452
-The public is invited to the annual September 11th observance at 9:00 am on Tuesday September 11th at the First Responders Tribute Garden located in Foundation Meadows part at 3210 Campbell in Valparaiso, The Cooks Corners 5th grade class will walk to the ceremony accompanied by the Valparaiso Fire Department honor guard. Principal Erin Utesch will speak on the history of 9/11. while Mayor Jon Costas and State Representative Ed Soliday will pay silence to reflect on the tragedy that affected all Americans that day. Deputy Fire Chief Steve Jacobs will have the closing comments of the ceremony. Any attendees at the ceremony are welcome to join the 5th graders in their process back to Cooks Corners Elementary School. In case of inclement weather, the event will be moved to the Parks Department maintenance building at the same site
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Use the Entire Site search box on the top of the page to return results across all our sites.
Our men's vintage hats were produced to commemorate special bands, concert, or events held by Bill Graham Presents. The authentically vintage styles include mesh caps, baseball hats, felt westerners, visors and painters caps. All of our hats are one size fits all, although because they are vintage they tend to run on the smaller size.
The Allman Brothers Band,
Warren Haynes,
Bernie Worrell


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Concerned citizens should be roused to action in light of the controversy surrounding Congressional debates in Rhode Island's Second District, specifically with regard to refusals by both Democratic incumbent Jim Langevin and Republican candidate Mike Riley to participate in any form of public debate with Independent candidate Abel Collins. This began with Langevin's and Riley's withdrawing from a WJAR roundtable discussion upon word of Abel Collin's inclusion, and this has been followed by a scheduled WPRI debate between the two to the exclusion of Mr. Collins.
It is shameful to think that our own Congressman Langevin, or challenger Mr. Riley, would refuse to engage with a candidate whose voice likewise represents the views of a significant portion of the electorate. Abel Collins' platform is a unique one, containing stances not held by his opponents, and he constitutes one-third of the ballot. He received a requisite 500 signatures to appear there in November. Those signatures represent the opinions of 500 registered voters in the district, and to them, and surely many others, Mr. Collins is a worthy candidate deserving of consideration.
We live in an America that witnesses a growing discontent with a stagnant, often vitriolic and dysfunctional two-party system. An increasing number of Rhode Islanders have shed their party ties to become unaffiliated voters. This is true not only at the state but also the national level, where during the 2012 election cycle we have witnessed an upsurge in support for third-party candidates with the likes of Libertarian candidate Gary Johnson and Green Party candidate Jill Stein. There is no doubt that Rhode Islanders' support for Abel Collins is symbolic of this phenomenon appearing across our republic.
The potential for an Independent candidate in our state is evident. Look no further than our state's chief executive, Independent Governor Lincoln Chaffee—the only current Independent governor in the United States. Additionally, out of a total of 253,699 likely voters for the upcoming election for the Second Congressional District, nearly half are unaffiliated. [1] If I, an unaffiliated voter and constituent of the district, should provide any explanation for this trend, it is that neither party's platform appeals to my particular set of values and opinions, and in each election a candidate's positions deserve to be independently considered regardless of party affiliation.
As a democrat, Congressman Langevin should indeed (as it appears he is) be troubled by the appearance of a serious, liberal-independent candidate on the ballot. Collins risks pulling voters from Langevin's base, thus tightening the gap between the incumbent and his challengers, and decreasing the congressman's chances for reelection. Yet who (with the exception of Congressman Langevin) should say that this is a bad thing? Rather it is a healthy sign for our democracy that voters have found someone to better represent their interests. The congressman should relish at the opportunity to sway votes back into his camp through an open debate with Mr. Collins regarding contentious issues. To refuse to do so both denies his constituents a fair glimpse of his continued worthiness to serve, and indicates that Mr. Langevin would rather win votes through a process of pigeonholing than through intellectual superiority and democratic choice.
Similarly, what harm is Collins' inclusion to Mike Riley's candidacy? The conservative platform of the former Wall-Street banker is virtually diametrically opposed to Collins', who was involved with the Occupy movement. Riley's support would certainly not wane with Collins' presence at the podium, as something tells me their respective supporters have already chosen sides. The only logical explanation for Riley's refusal to debate with Mr. Collins appears to be a refusal on his part to stand toe-to-toe with what Riley considers to be a less "serious" candidate. Quite the ego for someone who has yet to win elected office.
If either Jim Langevin or Mike Riley believes, as they both so rightly should, that the Rhode Island voter deserves the best possible representation in Washington, then they would not shrink, as they have, at publicly engaging the full spectrum of opinions that exists in this state. This is not advocacy for a candidate, but for process, one in which broadcasted debates play a vital role. They are the primary means through which voters can engage with their candidates and make informed decisions—particularly during a time of economic distress, when the working citizen often does not enjoy the luxury of extra time to actively partake in political life. To exclude the independent voice is to detract from the fairness of the democratic process and deny voters the full freedom of choice as envisaged by our founders.
Patrick Dolan
145 Cassandra Lane
North Kingstown, RI 02852
* It should be noted that while my position has no bearing on this election or these candidates, I serve as the campaign manager for incumbent state senator Dawson Hodgson (R), District 35. My opinions do not in any way represent those of the senator.
[1] rVotes Campaign Software (aggregates voter/election data into an electronic database available to assist campaign strategy)


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House of Week; 5535 Taft Avenue
Like New in Birdrock
Sought after quiet Birdrock location near the famous La Jolla beaches. Amazing panoramic ocean & sunset views. Meticulous interior design with bell waiter elevator. Environmentally friendly solar powered home. Almost 4,000 square feet of luxurious living space. Spacious backyard, patio, and rooftop deck areas for entertaining. Call for more info and to set up a showing.
Offered at $2,989,000
Tim Tusa
American Dream Homes
(619) 822-0093
Related posts:
- House of Week; 7033 Via Estrada
- House of Week; 774 Bonair Way
- Home of the week: 7550 Eads Avenue #208
- Home of the week: Heart of La Jolla Village
- House of the Week: 8070 La Jolla Scenic Drive North
Short URL: http://www.lajollalight.com/?p=101917
Posted by Staff on Feb 20, 2013. Filed under Featured House of the week, House of the Week. You can follow any responses to this entry through the RSS 2.0. You can skip to the end and leave a response. Pinging is currently not allowed.


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- Medizin (5)
- Philosophie (1)
- Die Welt jenseits der Oszillografen : ein Streitgespräch zwischen dem Hirnforscher Wolf Singer und dem Philosophen Marcus Willaschek (2005)
- Neurowissenschaftler fordern einen illusionslosen Umgang mit Begriffen wie Willensfreiheit und Bewusstsein. Philosophen kritisieren offen die Thesen von Hirnforschern. Stehen sich diese Positionen unversöhnlich gegenüber? Wo gibt es Möglichkeiten einer Annäherung, gar einer Kooperation? Der Religionsphilosoph Prof. Dr. Thomas M. Schmidt und der Biologe Stefan Kieß loten die Situation in Frankfurt aus; ihre Gesprächspartner sind der Hirnforscher Prof. Dr. Wolf Singer (links), Direktor am Max-Planck-Institut für Hirnforschung, und Prof. Dr. Marcus Willaschek (rechts), Philosoph an der Universität Frankfurt.
- A clinically relevant gene signature in triple negative and basal-like breast cancer (2011)
- INTRODUCTION: Current prognostic gene expression profiles for breast cancer mainly reflect proliferation status and are most useful in ER-positive cancers. Triple negative breast cancers (TNBC) are clinically heterogeneous and prognostic markers and biology-based therapies are needed to better treat this disease. METHODS: We assembled Affymetrix gene expression data for 579 TNBC and performed unsupervised analysis to define metagenes that distinguish molecular subsets within TNBC. We used n = 394 cases for discovery and n = 185 cases for validation. Sixteen metagenes emerged that identified basal-like, apocrine and claudin-low molecular subtypes, or reflected various non-neoplastic cell populations, including immune cells, blood, adipocytes, stroma, angiogenesis and inflammation within the cancer. The expressions of these metagenes were correlated with survival and multivariate analysis was performed, including routine clinical and pathological variables. RESULTS: Seventy-three percent of TNBC displayed basal-like molecular subtype that correlated with high histological grade and younger age. Survival of basal-like TNBC was not different from non basal-like TNBC. High expression of immune cell metagenes was associated with good and high expression of inflammation and angiogenesis-related metagenes were associated with poor prognosis. A ratio of high B-cell and low IL-8 metagenes identified 32% of TNBC with good prognosis (hazard ratio (HR) 0.37, 95% CI 0.22 to 0.61; P < 0.001) and was the only significant predictor in multivariate analysis including routine clinicopathological variables. CONCLUSIONS: We describe a ratio of high B-cell presence and low IL-8 activity as a powerful new prognostic marker for TNBC. Inhibition of the IL-8 pathway also represents an attractive novel therapeutic target for this disease.
- Final results of a phase I/II pilot study of capecitabine with or without vinorelbine after sequential dose-dense epirubicin and paclitaxel in high-risk early breast cancer (2010)
- Background: The integration of the non-cross-resistant chemotherapeutic agents capecitabine and vinorelbine into an intensified dose-dense sequential anthracycline- and taxane-containing regimen in high-risk early breast cancer (EBC) could improve efficacy, but this combination was not examined in this context so far. Methods: Patients with stage II/IIIA EBC (four or more positive lymph nodes) received post-operative intensified dose-dense sequential epirubicin (150mg/m2 every 2 weeks) and paclitaxel (225mg/m2 every 2 weeks) with filgrastim and darbepoetin alfa, followed by capecitabine alone (dose levels 1 and 3) or with vinorelbine (dose levels 2 and 4). Capecitabine was given on days 1-14 every 21 days at 1000 or 1250 mg/m2 twice daily (dose levels 1/2 and 3/4, respectively). Vinorelbine 25 mg/m2 was given on days 1 and 8 of each 21-day course (dose levels 2 and 4). Results: Fifty-one patients were treated. There was one dose-limiting toxicity (DLT) at dose level 1. At dose level 2 (capecitabine and vinorelbine), five of 10 patients experienced DLTs. Therefore evaluation of vinorelbine was abandoned and dose level 3 (capecitabine monotherapy) was expanded. Hand-foot syndrome and diarrhoea were dose limiting with capecitabine 1250 mg/m2 twice daily. At 35.2 months' median follow-up, the estimated 3-year relapse-free and overall survival rates were 82% and 91%, respectively. Administration of capecitabine monotherapy after sequential dose-dense epirubicin and paclitaxel is feasible in node-positive EBC, while the combination of capecitabine and vinorelbine as used here caused more DLTs. Trial registration: Current Controlled Trials ISRCTN38983527.
- A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP (2011)
- Parkinson's disease (PD) is a neurodegenerative disorder frequent at old age characterized by atrophy of the nigrostriatal projection. Overexpression and A53T-mutation of the presynaptic, vesicle-associated chaperone alpha-synuclein are known to cause early-onset autosomal dominant PD. We previously generated mice with transgenic overexpression of human A53T-alpha-synuclein (A53T-SNCA) in dopaminergic substantia nigra neurons as a model of early PD. To elucidate the early and late effects of A53T-alpha-synuclein on the proteome of dopaminergic nerve terminals in the striatum, we now investigated expression profiles of young and old mice using two-dimensional fluorescence difference in gel electrophoresis (2D-DIGE) and mass spectrometry. In total, 15 proteins were upregulated and 2 downregulated. Mice before the onset of motor anomalies showed an upregulation of the spot containing 14-3-3 proteins, in particular the epsilon isoform, as well as altered levels of chaperones, vesicle trafficking and bioenergetics proteins. In old mice, the persistent upregulation of 14-3-3 proteins was aggravated by an increase of glial fibrillary acidic protein (GFAP) suggesting astrogliosis due to initial neurodegeneration. Independent immunoblots corroborated GFAP upregulation and 14-3-3 upregulation for the epsilon isoform, and also detected significant eta and gamma changes. Only for 14-3-3 epsilon a corresponding mRNA increase was observed in midbrain, suggesting it is transcribed in dopaminergic perikarya and accumulates as protein in presynapses, together with A53T-SNCA. 14-3-3 proteins associate with alpha-synuclein in vitro and in pathognomonic Lewy bodies of PD brains. They act as chaperones in signaling, dopamine synthesis and stress response. Thus, their early dysregulation probably reflects a response to alpha-synuclein toxicity. Electronic supplementary material: The online version of this article (doi:10.1007/s00702-011-0717-3) contains supplementary material, which is available to authorized users.
- Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures (2011)
- Background: Current prognostic gene signatures for breast cancer mainly reflect proliferation status and have limited value in triple-negative (TNBC) cancers. The identification of prognostic signatures from TNBC cohorts was limited in the past due to small sample sizes. Methodology/Principal Findings: We assembled all currently publically available TNBC gene expression datasets generated on Affymetrix gene chips. Inter-laboratory variation was minimized by filtering methods for both samples and genes. Supervised analysis was performed to identify prognostic signatures from 394 cases which were subsequently tested on an independent validation cohort (n = 261 cases). Conclusions/Significance: Using two distinct false discovery rate thresholds, 25% and <3.5%, a larger (n = 264 probesets) and a smaller (n = 26 probesets) prognostic gene sets were identified and used as prognostic predictors. Most of these genes were positively associated with poor prognosis and correlated to metagenes for inflammation and angiogenesis. No correlation to other previously published prognostic signatures (recurrence score, genomic grade index, 70-gene signature, wound response signature, 7-gene immune response module, stroma derived prognostic predictor, and a medullary like signature) was observed. In multivariate analyses in the validation cohort the two signatures showed hazard ratios of 4.03 (95% confidence interval [CI] 1.71–9.48; P = 0.001) and 4.08 (95% CI 1.79–9.28; P = 0.001), respectively. The 10-year event-free survival was 70% for the good risk and 20% for the high risk group. The 26-gene signatures had modest predictive value (AUC = 0.588) to predict response to neoadjuvant chemotherapy, however, the combination of a B-cell metagene with the prognostic signatures increased its response predictive value. We identified a 264-gene prognostic signature for TNBC which is unrelated to previously known prognostic signatures.
- Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers (2013)
- INTRODUCTION: We examined if a combination of proliferation markers and estrogen receptor (ER) activity could predict early versus late relapses in ER-positive breast cancer and inform the choice and length of adjuvant endocrine therapy. METHODS: Baseline affymetrix gene-expression profiles from ER-positive patients who received no systemic therapy (n = 559), adjuvant tamoxifen for 5 years (cohort-1: n = 683, cohort-2: n = 282) and from 58 patients treated with neoadjuvant letrozole for 3 months (gene-expression available at baseline, 14 and 90 days) were analyzed. A proliferation score based on the expression of mitotic kinases (MKS) and an ER-related score (ERS) adopted from Oncotype DX® were calculated. The same analysis was performed using the Genomic Grade Index as proliferation marker and the luminal gene score from the PAM50 classifier as measure of estrogen-related genes. Median values were used to define low and high marker groups and four combinations were created. Relapses were grouped into time cohorts of 0-2.5, 0-5, 5-10 years. RESULTS: In the overall 10 years period, the proportional hazards assumption was violated for several biomarker groups indicating time-dependent effects. In tamoxifen-treated patients Low-MKS/Low-ERS cancers had continuously increasing risk of relapse that was higher after 5 years than Low-MKS/High-ERS cancers [0 to 10 year, HR 3.36; p = 0.013]. High-MKS/High-ERS cancers had low risk of early relapse [0-2.5 years HR 0.13; p = 0.0006], but high risk of late relapse which was higher than in the High-MKS/Low-ERS group [after 5 years HR 3.86; p = 0.007]. The High-MKS/Low-ERS subset had most of the early relapses [0 to 2.5 years, HR 6.53; p < 0.0001] especially in node negative tumors and showed minimal response to neoadjuvant letrozole. These findings were qualitatively confirmed in a smaller independent cohort of tamoxifen-treated patients. Using different biomarkers provided similar results. CONCLUSIONS: Early relapses are highest in highly proliferative/low-ERS cancers, in particular in node negative tumors. Relapses occurring after 5 years of adjuvant tamoxifen are highest among the highly-proliferative/high-ERS tumors although their risk of recurrence is modest in the first 5 years on tamoxifen. These tumors could be the best candidates for extended endocrine therapy.