text: Spring Wedges For Moms Shoe-In! The Best Spring Wedges For On-the-Go Moms by Lisa Horten 3/28/13 2 Reactions 10 Shares Print 3 0 7 0 0 Whether your Spring afternoons are going to be spent chasing tots or balancing a baby bump, wedges are the best shoes of the season for both busy moms and moms-to-be. The extra height elongates legs without the challenge of walking (or running) in heels. Since everyone's height threshold is different, choose a pair that you're comfortable and confident in. Just make sure that they have an ankle strap, because a backless shoe just isn't practical for a mama on the move! Kate Spade New York Carmelita Wedge Sandal What's Your Reaction? 0 0 0 0 0 0 Dress them up, or dress them down. Kate Spade's Carmelita Wedge Sandals ($258) are a playful and pretty way to show off your Spring pedicure. 1 / 9 Splendid Granite Wedge What's Your Reaction? 0 0 0 0 0 0 Easy, versatile, and feminine, Splendid's Granite Wedge Sandals ($95) would be great with a pair of cuffed (maternity or regular) jeans! 2 / 9 Forever 21 Neon Strap Wedge Sandals What's Your Reaction? 0 0 0 0 0 0 Low enough for running around the playground but still on-trend thanks to a playful neon strap, Forever 21's Neon Strap Wedge Sandals ($23) are a fun option for the budget-conscious mama. 3 / 9 KORS Michael Kors Valora Wedge Sandals What's Your Reaction? 0 0 0 0 0 0 The rich tan shade of these KORS Michael Kors Valora Wedge Sandals ($225) is sure to go with most everything in your closet, and the espadrille heel transitions easily to Summer. 4 / 9 TOMS Brushed Metallic Cork Wedges What's Your Reaction? 0 0 0 0 0 0 TOMS used to be known only for its signature supercasual slip-ons. For the past few seasons, however, the brand has introduced more fun, stylish options that still support its "one for one" mission. These Brushed Metallic Cork Wedges ($140) would be perfect for Spring strolls in the park and playgroups. 6 / 9 Tory Burch Adonis Wedges What's Your Reaction? 0 0 0 0 0 0 A classic option for the traditionalist, Tory Burch's Adonis Lower Wedge Espadrilles ($185) come in navy, bleach, or army green. 6 / 9 Salvatore Ferragamo Patent Cork Wedges What's Your Reaction? 0 0 0 0 0 0 A dressier selection, Salvatore Ferragamo's My Sunset Patent Cork Wedges ($395) would be great for Spring parties — especially those where you're likely to be chasing around the little ones. 7 / 9 Marc by Marc Jacobs Demi Wedge Sandals What's Your Reaction? 0 0 0 0 0 0 If you splurge on one new pair of sandals this season, then these Marc by Marc Jacobs Demi Wedges ($174, originally $248) just may have to be it. They come in vibrant pink and yellow, glam rose gold, or classic black. 8 / 9 Eric Javits Effie Braided Wedge What's Your Reaction? 0 0 0 0 0 0 Eric Javits's Effie Braided Raffia Wedges ($200) are the ultimate transitional Spring sandals — perfect for day-to-night wear. 9 / 9 3 0 7 0 0 Back to Homepage Comments Read More Mom ShoppingSpring ShoesSpringWedges Spring 40 Outdoor Date Ideas For Summer Lovin' 7/20 9 Ways to Brighten a Dark Home 7/18 20 Prime Recipes to Pack on a Picnic 7/18 The Patio Anyone Can (and Should) Copy 7/11 Floral Centerpieces For Every Occasion 7/07 18 Appetizing (and Healthy!) Strawberry Recipes 6/23 What's Your Reaction? 0 0 0 0 0 0 0Reactions Link Love Mom forced to stop feeding baby homemade formula — BabyCenter Blog The easiest ways to save on organic food — The Stir A look inside Fergie's second baby shower — Celebrity Baby Scoop Danielle Jonas debuts her baby bump — People Moms & Babies 7 light and fresh recipes to take you through Summer — FitPregnancy Does where you live affect your risk for PPD? — The Bump Where to find the best deals on school supplies — Real Simple Now this is how you announce a pregnancy! — HuffPost Parents


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Fire investigators in Oregon are investigating what caused a shed to catch fire overnight.
Firefighters were called to a home on the 1300 block of Harbor View Drive around 2 a.m., Sunday.
There was heavy smoke damage, and fire crews same flames spread to a nearby garage.
The exact amount of damaged caused has not yet been released.
Copyright 2013 Toledo News Now. All rights reserved.
730 North Summit Street
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subset: commoncrawl


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Proposals put forward for prisoners' right to vote
The Justice Secretary Chris Grayling has outlined proposals for what should be done about prisoners' right to vote.
Under a ruling by the European Court of Human Rights, Britain must remove its blanket ban on prisoners voting by tomorrow (November 23rd).
A special committee is being set up to consider the idea.
The three proposals put forward by the Justice Secretary are as follows:
Prisoners who have been sentenced for less than four years could have the right to vote
The right to vote could be limited to those serving prison sentences for six months or less
MPs could restate the current position - that is that no one serving time in prison has the right to vote


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7-Day Archives
Saturday, June 14
Start your day with a roundup of top defense news.
The latest news from Flightlines
- Al-Qaida pamphlet urges attack on Air Force Academy
- QF-16 takes first flight as a target
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All you need to know about your military benefits.
Guard & Reserve All you need to know about the Guard & Reserve.


text: Dusty Baker won't manage the Cincinnati Reds until the final series in St. Louis, giving him time to recover from an irregular heartbeat that left him hospitalized last week. Baker met with owner Bob Castellini and his team on Tuesday before a game against the Brewers. Bench coach Chris Speier said he'll manage the final three home games against Milwaukee and three in Pittsburgh over the weekend, with Baker taking over for the last three games next week. The 63-year-old manager was hospitalized in Chicago last Wednesday for an irregular heartbeat, a problem he's had for a while. He was in the hospital for four days, missing the Reds' 6-0 win over the Dodgers on Saturday night that clinched the NL Central title.(Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


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Assistant Pathologist
Massachusetts General Hospital
Assistant Professor in Pathology
Harvard Medical School
Email: firstname.lastname@example.com
Cogan Laboratory, Massachusetts Eye and Ear Infirmary
Molecular Neuro-Oncology Laboratory
Our lab's research focuses on identifying the underlying molecular changes in the lesions and malformations associated with hereditary brain tumor syndromes (neurofibromatosis 1, neurofibromatosis 2, schwannomatosis and tuberous sclerosis), and the identification of activated pathways or events that lead to tumor progression.
See details at the Stemmer-Rachamimov Lab.
Phone: 617-726-5510
Phone 2: 617-726-5156
Fax: 617-724-1813


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Gulf view tropical condo at Lido Beach--May available in Lido Key
- bedrooms 2
- baths 2
- sleeps 4
- pool yes
- hot tub no
- pets allowed no
- type Condo
- community Lido Shores
- rates (USD) $ 2,200 - $ 4,000 / month
vacation rental description
Beautiful views of Gulf of Mexico, Lido white beach, colorful
sunsets in the west, and sunrises on the east.
Refreshing cross-breezes through the condo.
Four blocks to famous St. Armands Circle, fine restaurants, shopping.
Enjoy beautiful Sarasota, fine dining, theater, opera, ballet, art
galleries, antique shops, museums, Ringling home, Mote Marine,
South Lido Park for picnics, beach, or nature walk.
World famous Selby Botanical Gardens and orchid collection.
Nearby fishing, sailing, golfing, tennis, bicycling, kayaking.
One hour to Tampa airport, parks, museums, sporting events.
Two hours to Orlando attractions.
Fully furnished, tropical, modern furnishings, well supplied
kitchen, linens, towels, beach chairs.
vacation rental location
property availability
- dates with deals
- unavailable dates
Last modified on 07-1-2014 at 9:34 AM.
email owner view full calendar
Gail Zittel 941-552-6448
condo rental amenities
Cheerful, open, Florida beach get-away!
High-end upgraded kitchen with light maple custom cabinets and granite
counter-tops: all new kitchen appliances, microwave, ceramic top stove, refrigerator, toaster oven, dishwasher, all small appliances, dishes, cookware, spices, and kitchen linens.
Bathrooms newly remodeled, bright & beautiful! Shower has built-in bench, relaxing soaker tub, grab-bars. Plenty of matching towels for bath and beach
Two bedrooms, one king bed with new Sealy mattress, two twin beds. All bed linens provided.
Large flat screen TV with cable, bedroom TV's, DVD-CD player, radio Wireless high-speed internet
Couches with recliners, and leather recliner, Desk & chair
Dining room seats 4 with an additional 4 bar stools at counter.
Patio furniture to enjoy beach view & sunsets.
For the beach: beach chairs, umbrella, noodles, large beach towels.
Pool, heated in winter months, Poolside gas grill, Meeting room
Secured lobby entry Covered parking Laundry room on floor
4th Floor, Elevator & Stairs. New tile, carpet, paint. Adults only. No smoking. No Pets. CLEAN, COMFORTABLE, BRIGHT, & MODERN
activities and attractions in Lido Key Gulf Coast Central
Swimming, fishing, boating, beach walking, bicycling, shopping, theater, museums, antique shops, casual & fine dining, kayaking, Myakka Park.
Just relaxing!!!
vacation rental rates
Jan, Feb, March $4,000.00 month
April $2,400.00 month
May, Oct, Nov $2,200.00 month
December $2,500.00 month
June through September--not available for rent
Monthly rentals only, 30 day minimum
For availability, check calendar above
Damage deposit $500
Cleaning fee $85 (Standard 3 hour cleaning)Full payment required to reserve condo.
References requested.
Cancellation with 60 days or more advance written notice: amount received minus $200. Cancellation with 30-59 days written notice: one half rental fee refunded.
Cancellation less than 30 days notice: no refund.
Gail Zittel 941-552-6448
accepted payment methods
Prior to paying a reservation deposit, always verify payment instructions by calling the phone number displayed on this listing page. By contacting the owner directly and paying by an approved method - credit card, paypal, check or bank transfer - your reservation payment will be protected up to $1,000.Learn more in our Security Center
Top things to do in Lido Key
- Swim and Sun
- St. Armands Circle
- Great dining
- Unique Shopping
- Mote Marine-See manatees
Top things to do on a budget
- Enjoy the beach
- Walk, jog, bicycle
- Get ice cream
- Farmer's Market Saturday AM downtown
- Explore South Lido Park
Top things to do with a family
- Beach
- Mote Marine Boat Trip
- Go fishing
- Rent a wave-runner, kayak, paddleboard
- Jungle Gardens/Selby Gardens
Gail Zittel , owner


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Jamie Andrus
Jamie graduated with her bachelor's degree in human resource management in 2009 and later received her master's degree in human resources in 2010 from the Huntsman School of Business.
While attending classes full time she held the position of recruiting associate for the MHR program. Jamie was also the seminar coordinator for the SHRM Crossroads Conference. She interned at Rio Tinto and at Convergys.
Before returning to school at USU, Jamie worked in the dental field and was a small business owner. She participated in community theater and was a dance instructor. She has had numerous volunteer opportunities in community, schools and church. She enjoys music, dance, cooking, gardening and skiing.


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UPDATE (Nov. 20, 10:30 p.m.)—The Silver Alert for Clarence Leroy Wessel has been canceled. "He has been located and is safe and well," police announced.
UPDATE (Nov. 20, 9:57 p.m.)—Baltimore County police are requesting the public's help in locating a White Marsh man who went missing late Tuesday morning.
Clarence Leroy Wessel, 82, was last seen at his home at about 11 a.m. on Nov. 20 in the 700 block of Gaylord Street in White Marsh. He had planned to drive to the MVA office at North Plaza Mall in the 8900 block of Waltham Woods Road in Parkville, according to the Silver Alert issued by police Tuesday night.
Wessel is described as 5-foot 5-inches tall, 170 pounds, with green eyes, gray hair and glasses. He was last seen wearing a royal blue windbreaker, jeans and blue sneakers. His vehicle is a tan four-door 2004 Chevrolet Celebrity with Maryland registration RRH370, according to police.
Anyone with information is urged to call police at 410-307-2020.


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Meghan Heuer tops 1500 meters record, 4x400 relay mark beaten by five seconds
Meghan Heuer, Sidra Sherrill add names to record book
Huskies take second-place finishes in three events
Freshman tops former school mark en route to first-place tie
Freshman Jasmine Wilson qualifies for MAC Championships in javelin
2013-14:Indoor- Did not compete. Outdoor-Competed a six meets during the season... Set a new personal record in the 200 meters with a 25.43 run at the Wisconsin Open (5/10), finishing fifth... Placed 19th in the 100 meters at the MAC Championships (5/16) with a time of 12.51... Ran a season-best 100 meters time of 12.17 at Wisconsin... Took fourth in the 100 meters at the Cougar Classic (3/22).
2012-13: Indoor- Saw action in three meets... Registered a 27.44 time in the 200 meters at GVSU Big Meet (2/9)... Placed 13th in the 60-meter dash at the Ball State Quad (2/15)... Outdoor- Competed in seven events... Recorded her best 100 meters time, 11.99, at the Chicagoland Championship (4/6)... Finished third in the 100 meters at the Huskie Open (4/20)... Recorded a 12.10 100 meters prelim time at the MAC Championships (5/10)... Registered a season-best 26.04 200 meters time at the Sea Ray Relays (4/12).
2011-12: Indoor- Ran in three meets during the indoor season... Set a personal record in the 60 meters at the Cyclone Holiday Preview (12/9) with a 7.84 run to finish in sixth place. Outdoor- Did not compete.
2010-11: Indoor- Ran a personal-best time of 7.93 in the 60-meter dash at the Iowa State Classic (2/10) ... placed sixth at the Ball State Quadrangular (2/18) in the 60-meter dash with a time of 7.97 ... earned a third-place finish at in the 200 meter dash at the Ball State Quad (2/18) with a time of 26.06 ... placed sixth at the Indiana Wesleyan Invite (1/29) with a time of 26.94 in the 200 meter dash. Outdoor-Recorded a time of 25.20 in the 200-meter dash with a new personal record of 25.20 at the Point Loma Nazarene Invitation (3/12) ... Completed the 100-meter dash in 12.26 seconds... Assisted the Huskies in breaking the school-record and first place win in the 4x100 relay ... took fourth-place at the Tom Botts Invitational (4/09/11) in the 100-meter dash with a time of 12.06 ... contributed to the Huskies first place finish in the 4x100-meter relay with a time of 46.54 ... contributed to the sixth-place finishes of both the 4x100-meter relay (47.03) and the 200-meter relay (1:41.25) at the Tennessee Sea Ray Relays (4/16/11) ... Placed third in the 100-meter dash with a time of 12.15 at the Huskie Open (4/23) ... contributed to the 4x200-meter relay team seventh-place finish crossing the finish line with a time of 1:37.99 at the Drake Relays (4/27) ... Assisted the Huskies to a 10th-place finish in the 4x100-meter relay with a time of 46.52 ... Placed second in the 100-meter dash at the Whitewater Invitational (4/30) with a time of 11.88 (wind-aided)... helped NIU capture the MAC Championship in the 4x100-meter relay with a winning, and school-record, time of 45.64 seconds (5/14) ... also finished ninth in the 100-meter dash at the MAC Championships with a time of 11.87 seconds ... competed in the 4x100-meter relay at the NCAA West Preliminary, helping the Huskies to a 23rd place finish (46.64 seconds) (5/28).
Personal:Born on Nov. 2, 1990... daughter of Lisa Smith... majoring in general studies.


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17-12-2011 19:35
Windows 7 Premium x64. Install Nokia Suite 3.2.100. It installs with no errors. Connect 701 via USB cable, more drivers install with no errors. When I tell it to check for updates I et the following message;
"Somethings gone wrong. It seems that some program files of Nokia Suite are missing. To fix this, please uninstall nokia suite and download the latest version of the application ..."
I've done this mulitple times and receive the same message.
Solved! Go to Solution.
19-12-2011 10:44
Hi Williamtell64
There is a problem with the suite for Win7 64-bit users.... You're not the only one and There isn't a solution available as yet... Also facing the same problem
Can you load Maps though?
19-12-2011 13:55
I had to update my maps through the phone. Nokia Suite maps has an error. Thanks for the info of the Nokia Suite problems
19-12-2011 14:02
Guess I'll wait for the Nokia Suite update...
17-04-2012 9:08
Error has been fixed and Nokia Suite 3.4 contains the fix. You can download and install latest beta version of Nokia Suite from here ...
To download the installer, you need to log-in with the SAME credentials that you use on this Forum..
Best regards,
Nokia Suite team


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Tropical Waterfront Island Pool Home with Kayaks! in Tarpon Springs
- bedrooms 3
- baths 3
- sleeps 9
- pool yes
- hot tub no
- pets allowed no
- type House
- community
rates (USD)
/ week
$ 4,000 - $ 6,000 / month
vacation rental description
This beautiful privately owned home in a small island neighborhood is perfect for couples, honeymoons, families, reunions or a girlfriend getaway. It is lavishly furnished in bright tropical hues with a Key West feel and faces northwest to experience gorgeous sunsets. The deck is brand new and spacious, equipped with a grill for barbequeing, a sparkling pool, plenty of comfy patio furniture for sunbathing, relaxing or just enjoying the view. Enjoy Al fresco dining or a cool drink in your beautiful private waterfront backyard where you have dolphins, manatee, and even a bald eagle as your neighbor! You can fish right out your back door, or pick up something to grill from one of several fresh fish markets.
This 3 Bedroom 3 Bath home with a loft is located in Tarpon Springs, one of the best-kept cultural secrets in Florida. It is one of the largest Greek communities outside of Greece and listed in the National Registry of Historic Places. Its yearly calendar is filled with Greek festivals, street dancing, music and events. Just a few minutes by boat will take you to the beautiful open water of the Gulf of Mexico, where you may visit Anclote Key and its famous lighthouse immortalized by singer Bertie Higgins! Here you can hike, snorkle, collect shells, visit the lighthouse or just relax on an island maintained in its pristine and natural condition. Other beaches in the area are the equally lovely Honeymoon Island, and Caledesi Island State Park, which is consistently ranked as one of the most beautiful beaches in the U.S.
With plenty of windows in the house and two kayaks for guest use, you will enjoy to the fullest what you came to Florida to do--enjoy the sunshine and warm temperatures, which are year round. Take out a kayak and explore one of the many uninhabitied islands that dot the river where you may see herons, egrets, eagles, osprey, manatee, tarpon, dolphins, sting ray, the elusive rosette spoonbill, and much more all in their protected habitats. Sunset Beach, known for its sunset concerts, and Fred Howard Park Beach with wonderful picnic facilities, wind surfing and playground are both just a short drive away, as well as the world renown Innisbrook Golf Courses. Tarpon Springs even has its own picturesque course where you can warm up!
Please note there is no safety fence around the pool area, and no fence around the home where it backs up to the water. Therefore, the property may not be suitable for small children and nonswimmers.
The home is located in a quiet, private island neighborhood in Tarpon Springs, approximately 25 minutes from the Suncoast Parkway, approximately 40 minutes from highway 75. St. Petersburg/Clearwater is about 30 minutes south and Tampa is about 40 minutes east. Orlando and the Disney vacation land is just a quick 1 1/2 hours east.
vacation rental location
property availability
- dates with deals
- unavailable dates
Last modified on 07-7-2014 at 3:51 PM.
email owner view full calendar
Diane Underwood 605-695-0708
house rental amenities
This home is truly your own private waterfront resort, featuring spectacular views and private pool with solar heater. The kitchen is newly updated with stainless appliances and granite countertops. It is fully equipped for any culinary desire or special occassion. The family room has plenty of comfortable seating for watching the large screen TV in a stunning great room layout. A breakfast nook and an additional dining room provide ample dining space for everyone.
The Master Bedroom suite is luxuriously appointed with a kingsize bed, walk-in closet, elliptical trainer, and TV. The adjoining master bathroom has his and her granite sinks and a large garden tub. Two more equally beautiful bedrooms upstairs have queen beds and tropical furnishings. A lofted area with bunk sleeping for 3 more brings the sleeping total to 9. With its own TV, the loft area is perfect for teens and children who want their own space while the grownups hangout downstairs.
Cable and wireless internet are included in the rental fee. There are ceiling fans throughout the home, solar heater for the pool to remove some of the chill, and romantic pool lighting for evening swims. There are even some citrus trees outside for your fresh squeezed juice!
Two sea Kayaks are included with the rental and are yours to explore the gulf and inland waterways full of mangroves and manatees and all the lush tropical wildlife you can imagine. Plush outdoor living furnishings to relax and soak up the sunshine, are waiting for you on the deck when you return.
All linens and towels are provided, as well as an indoor laundry room with washer and dryer.
Celebrating a special occasion or a honeymoon? We have packages available that can make your time even more special--from birthdays, to anniversaries, Valentine's Day and more. Ask us about details.
activities and attractions in Tarpon Springs Gulf Coast Central
If you decide to venture out from your fabulous vacation home, there are plenty of other things to do and see in Tarpon Springs.
The Coral Springs Aquarium, the Scenic Pinellas Trail for hiking, biking or jogging-bike rentals available at Tarpon Toms, Tarpon Tavern and craft beers, a winery with tour and tasting room, the antique district with its red brick streets and cafes, the historic Railroad Museum, art galleries, a day spa, Greek culture, shopping and food at the world famous Sponge Docks, beach concerts and movies at Sunset Beach, picnicing at Howard Park, restaurants featuring some of the freshest seafood around brought in daily by their own boats, Brooker Creek Nature Preserve and hiking trails, charming Victorian homes, deep sea fishing trips on the Viking Fleet, sailing and sightseeing excursions, private boat rentals at Belle Harbor Marina, scuba diving, tennis, street festivals, farmer's market, art shows, paddle board rentals, Jolly Trolly that provides service as far south as Clearwater, delectible Greek pastries, and a very busy events calendar and theater schedule. Our guest book is filled with local information, restaurant menus and savings, discounts on boat rentals, tide charts, fishing info, events calendar and much more!
We are sure that once you experience Tarpon Springs and this beautiful rental, you will want to come back again and again.
20 minutes to Brighthouse Fields Spring Training Camp for Philadelphia Phillies
1 .5 hour drive to Orlando Amusement Parks including Disney World, Epcot, Islands of Adventure, Universal Studios, MGM, and Sea World
45 minute drive to Busch Gardens and Adventure Island Amusement Parks
50 minutes from Hard Rock Hotel and Casino and Ford Amphitheatre
45 minutes from Tampa International Airport
30 minutes from St. Pete/Clearwater Airport
Several Championship Golf Courses in the surrounding area
45 minute drive to Weeki Wachee Water Park home of the famous mermaid show.
vacation rental rates
Refundable deposit $300. provided property is damage-free and only normal cleaning required.
There is a -$150-200 cleaning fee, and 12% combined Florida sales/resort Tax.
Additional nights can be added to the weekly rate for $180-$250 per night depending on time of year and number of guests.
Diane Underwood 605-695-0708
accepted payment methods
Prior to paying a reservation deposit, always verify payment instructions by calling the phone number displayed on this listing page. By contacting the owner directly and paying by an approved method - credit card, paypal, check or bank transfer - your reservation payment will be protected up to $1,000.Learn more in our Security Center
Top things to do in Tarpon Springs
- Fishing
- Sponge Docks
- Shopping
- Dining
- Boating
Top things to do on a budget
- Walking
- Fishing
- Sight seeing
- Free Parks
- Sun Bathing
Top things to do with a family
- Tarpon Springs Aquarium
- Fishing
- Several Nature Parks
- Beaches
- Sight Seeing
Diane Underwood , owner


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Residencia La Ciutadella
La Ciutadella Youth Hostel was inaugurated in January 2001, as part of a deal with the Universitat Pompeu Fabra. The hostel accommodates students of both genres and includes 270 rooms.
Availability & RatesTo view availability and prices please select dates and click 'Update Dates'
Hostel Facilities & Policies
- 24 hour reception
- Bicycle parking
- Breakfast Included
- Card phones
- Common Room
- Credit Cards Accepted
- Elevator
- Fax Service
- Free City Maps
- Free Internet Access
- Free Wifi
- Games Room
- Gym
- Kitchen
- Linen Included
- Luggage Storage
- Non Smoking
- Parking
- Reading Light
- Taxes included
- Towels Included
- Vending Machines
- Washing Machine
- Wheelchair Accessible
Cancellation PolicyThis property has a 1 day cancellation policy. Failure to cancel within this time will result in a cancellation charge equal to the first night of your stay.
DirectionsShow MapHide Map
The Hostel is situated in a central location, since it is in front of the well-know La Ciutadella Park, only a 10 minute walk away from the Ramblas, 20 minute walk away from the beach amd from the Sagrada Fam�lia.
The closest Metro stations are Metro Line 1: Marina or Arc del Triomf, and Metro Line 4: Ciutadella or Bogatell .
As for metropolitan Buslines, the nearest are the bus stops numbers 14, 39, 40, 41, 42, 51 and 141.
We are 5 minute walk away from Barcelona Nord bus station to travel to different areas in Catalonia, as well as, to the main cities along Spain and Europe.
There is the tram in front of the residence to go to the Forum or Diagonal Mar.
We are near the train stations of Arc del Triomf and Fran�a.
Located Near
The Hostel is situated in a central location, since it is in front of the well-known La Ciutadella Park, only a 10 minute walk away from the Ramblas, 20 minute walk away from the beach and from the Sagrada Família.


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Terminal 4 Upper Departure Level
A1A Travel Mart - Offers an extensive assortment of news, magazines, books, convenience items, snacks, and local merchandise. It's an ideal stop for people on the run!Hours: 4 a.m. - 11:30 p.m.
Public Bag Storage
Public Baggage Storage - If flight time allows, enjoy exploring the airport or surrounding communities without taking your luggage with you by using the secure baggage storage service. For more information, call 954-359-5505.
ATM and Phone Cards
ATM - Automated teller machines and pre-paid phone cards for local and international calling.Hours: 24 hours a day
Postage Stamps
US Postal Service - Machines to purchase postage stamps.Hours: 24 hours a day
Currency Exchange
Currency Exchange - Services for international passengers.Hours: 8:30 a.m. - 7:30 p.m.


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Post by Dan @ 05:09pm 23/11/12 | 38 Comments
Since the very early days of videogames, Australian gamers have been paying a higher price for their favourite pastime than those from lands across the sea. Once upon a time there were many valid reasons for this, but are they still relevant today?
The Internet has rocketed awareness of these differences, now affectionately known locally as The Australia Tax, and it endures even in digitally distributed products we buy direct from international websites. But there is a lot of confusion and misdirected anger about exactly who is responsible, and how it can be addressed.
In the throes of another holiday shopping season, with the year's top videogame launches still setting records above all other entertainment mediums, we take a look at the factors and forces responsible for the disparity in retail prices for games in Australia relative to other developed nations, and discuss what Australian consumers can possibly do about it. Read on for our in-depth analysis.
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Naperville, ILUSA 60540
January 1, 2013
Hi, I'm Deborah, Look forward to experiencing new and different sounds music expression!
All varieties of music from rock to classical.
Through other meet up venues.
Hi, How are you doing over there .... I really love your profile. would love to talk to you & get to know more about you...I'm a busy kind of person i come on here once in a while you can text me on [masked] if you care for a chat ,..i will be expecting Your text ....Take care
Hi Deborah. Do you use a shortened version of your name if not its all well! :) Welcome to the group!
Thank you for joining & welcome!
Welcome Deborah! We look forward to meeting you at an upcoming event. I'm sure you'll enjoy our rides and also making new friends who love to cycle too!
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You can use the very cool cloud-based system provided by EDA Playground
Would you use a cloud-based IDE?
Arrayent's technology was recently embedded in an Internet-enabled thermostat from Hunter Fan.
This month,
we show you how to use Microsoft's TypeScript as a productive superset of JavaScript, how to use OData in Microsoft Web apps, and how continuous testing in the dev cycle will save time and sanity. As always, this is useful, bits under the fingernails, approachable information that you can put to work right away
, and much more!
Download the latest issue today. >>


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On Wednesday, September 12, 2012 the University of Notre Dame officially became a member of the Atlantic Coast Conference. All of Notre Dame's athletic programs, except for football, will fully compete in the ACC. Starting in 2013, all other ACC football programs will play 9 conference games each year, while Notre Dame's football program will compete in only 5. This special arrangement allows the Fighting Irish to keep their football independence, while initiating a severely impactful culture change in the ACC. A culture of concessions and special treatment for Notre Dame will negatively impact many future situations the conference will encounter. This type of culture will weaken the ACC in the long run.
Do you dream of bathing in an unending wave of college football goodness? Do you ever feel like you just see too much of your girlfriend, the sun or your Jack Russell, Bo? If so, do we have...
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United Kingdom Parliament
Privy Council: The Rt Hon
All Cabinet Ministers of the United Kingdom Parliament are members of the Privy Council. Other Ministers outside the Cabinet may also be admitted to the Privy Council. It is an appointment that is held for life.
Some junior Ministers of any particular administration may not be admitted to the Privy Council, but most of these are Members of Parliament, and others may have seats in the House of Lords.
Privy Counsellors have the prefix 'The Rt Hon' before their names. Mr is dispensed with, but if a Privy Counsellor is also a knight, his style of address would be 'The Rt Hon Sir John Smith'. If the Privy Counsellor is female 'The Rt Hon' replaces Mrs/Miss/Ms in her style of address, but if she is also a dame, her style of address would be 'The Rt Hon Dame Elizabeth Brown'.
All Members of the House of Commons of the United Kingdom have the letters MP after their names.


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Search for exciting venues and eventsFind a Venue
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Building 6 occupies a purpose-built, 33,000sq ft space within The O2. Spread across three levels, it comprises four bars, three dance floors, two entertainment rooms, two mezzanine levels… more »
New review coming soon Venue review of Building Six at The O2 … more »
Tracing the history of London's river, ports and people, the Museum of London Docklands is Canary Wharf's only Grade I-listed venue. Spread… more »
With a commanding position on the fourth floor of Canada Place, Plateau is a go-to for glamorous Christmas parties in Canary Wharf. Its… more »
If you're looking for a venue for a private film screening, Cineworld is an obvious choice. The chain has 801 screens spread across 78 cinemas… more »
If you're looking for a venue for a private film screening in the Docklands area, Cineworld West India Quay is an obvious choice. The East… more »
London's famous entertainment venue The O2 is home to one of the city's largest cinemas. Cineworld at The O2 has state-of-the-art digital… more »
Established in 1870 and still owned by the same family, Davy's has over 25 bars and restaurants in locations throughout the City and West… more »
This spectacular arched glass atrium in Canary Wharf soars above 682sq m of coloured marble floors. It has beechwood panelling on two walls… more »
Designed as a music venue that could also meet the needs of corporate event organisers, indigO2 combines clubby interiors with an easily adaptable… more »
Tracing the history of London's river, port and people from the arrival of the Romans to the rise of Canary Wharf, the Museum of London… more »
Since it started life catering on the dinner-party circuit in 1975, Party Ingredients has built up a solid base of high-profile events that… more »
Established in 1975, Party Ingredients may have started on the dinner party circuit, but the company now caters to high-profile events including… more »
Established in 1975, Party Ingredients may have started on the dinner party circuit, but the company now caters to high-profile events including… more »
Plateau sits in a prime fourth-floor position at the top of Canada Place, with views across the lawns and sculptures in Docklands' Canada… more »
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Professor Kanter publishes and lectures extensively on United States, comparative, and international Disability Law. She is the co-author of the first law casebook on international and comparative disability law and has published numerous articles and book chapters on disability law. In 2010-11, she was named the Distinguished Switzer Fellow by the US Department of Education's National Disability Rehabilitation Research Institute. In 2009-10, she was a Fulbright Scholar. In 2005, she received Syracuse University's most prestigious teaching award, the Laura J. and L. Douglas Meredith Award for Excellence in Teaching. She also holds a courtesy appointment in the School of Education. Professor Kanter is founder and co-editor of the SSRN Journal on Disability Law, and co-founder of the Disability Law Section of the American Association of Law Schools. She is a former Commissioner of the American Bar Association's Commission on Mental and Physical Disability Law. From 2001-06, Professor Kanter was invited to work with the United Nations on the process that lead to the UN Convention on the Rights of People with Disabilities, and is currently researching the impact of this Convention in various countries, particularly in the Middle East. She has been invited to work with NGOs and governments in such countries as India, Israel, Turkey, Ghana, Jordan, and Vietnam on developing their domestic disability laws. At Syracuse University College of Law, Professor Kanter founded and directs the Disability Law and Policy Program, which houses the nation's first joint degree program in Law and Disability Studies and which awards a Certificate in Disability Law and Policy to eligible students. She also co-directs the Syracuse University Center on Human Policy, Law, and Disability Studies, which is the nation's first multi-disciplinary center dedicated to research, advocacy, academic programming, and public education on issues of inclusion and equality for people with disabilities. Professor Kanter teaches courses on U.S., comparative, and international disability law and policy, education and special education law, legislation and policy, ethics, and professionalism.Since joining the law faculty in 1988, Professor Kanter has served as Associate Dean for Academic Affairs, Director of Clinical Legal Education, and Director of the Externship Program. Since 2005, she has been the Chair of the Chancellor's Task Force on Disability. Prior to joining the SU law faculty, Professor Kanter taught at Georgetown University Law Center and practiced public interest law at a national disability rights organization in Washington, D.C. where she represented clients before the United States Supreme Court and in Congress.
Encyclopedia of Human Rights (5 Vol.), David Forsythe, ed., Chapters, (Oxford University Press 2009).
Encyclopedia of American Disability History (3 Vol.), Susan Burch, ed.,Chapters, (Infobase Publishers 2009) .Learning from Practice: A Professional Development Text for Legal Externs, Second Edition, and Teachers' manual J.P. Ogilvy, L. Lerman, L. Wortham, Kanter, et. al., (West, 2007) CASES AND MATERIALS ON INTERNATIONAL HUMAN RIGHTS AND DOMESTIC MENTAL DISABILITY LAW, M. Perlin, A. Kanter, M.P. Treuhart, K. Gledhill, & E. Szeli, (Carolina Academic Press, Spring 2006).INTERNATIONAL HUMAN RIGHTS AND DOMESTIC MENTAL DISABILITY LAW DOCUMENT SUPPLEMENT, M. Perlin, A. Kanter, M.P. Treuhart, K. Gledhill, & E. Szeli, (Carolina Academic Press, Spring 2006). BEHIND CLOSED DOORS: HUMAN RIGHTS ABUSES IN THE PSYCHIATRIC FACILITIES, ORPHANAGES AND REHABILITATION CENTERS OF TURKEY, (Mental Disability Rights International, September 28, 2005) Primary author of legal analysis section.
The Globalization of Disability Law, chapter in P. Blanck, Ed., DISABILITY RIGHTS, Ashgate Pub. (2005). Students with Disabilities Studying Abroad, chapter in RIGHTS AND RESPONSIBILITIES OF STUDENTS WITH DISABILITIES, Mobility International USA (2004). Foreign Policy and Disability: Legislative Strategies and Civil Rights Protections to Ensure Inclusion of People with Disabilities, Report commissioned by the National Council on Disability (with E. Rosenthal) (September 9, 2003).
The Right to Community Integration: Protections under United States and International Law, chapter in DISABILITY RIGHTS: INTERNATIONAL AND NATIONAL PERSPECTIVES, (with E. Rosenthal), M. Breslin, S. Yee A. Meyerson, eds., Transnational Publishers (2002).
Towards Equality: The Americans with Disabilities Act: Accommodation of Differences, chapter in Lee Ann Basser Marks and Melinda Jones, eds., DISABILITY, DIVERS (ABILITY) AND LEGAL CHANGE, Kluwer Publishers (1999).
Legal and Ethical Issues in the Community Care of Older People, and Protecting Elders Rights, chapters in AT HOME: STRATEGIES FOR SERVING OLDER PEOPLE WITH MENTAL DISABILITIES IN THE COMMUNITY (1995).
The Housing Needs of People with Mental Illness, in OUTCASTS ON MAIN STREET - REPORT OF THE FEDERAL TASK FORCE ON HOMELESSNESS AND SEVERE MENTAL ILLNESS (May 1992).
CURRENT ISSUES IN MENTAL HEALTH LAW, University of Texas, (1989).
A Brief History of Deinstitutionalization, chapter in PROTECTION AND ADVOCACY FOR PEOPLE WHO ARE LABELED MENTALLY ILL (1987).
Combating NIMBY: Recent Zoning Cases Uphold the Establishment of Group Homes for the Mentally Disabled, chapter in PROTECTION AND ADVOCACY FOR PEOPLE WHO ARE LABELED MENTALLY ILL (1987). Recent Articles: The Law: What's Disability Studies Got to Do With It or An Introduction to Disability Legal Studies, Columbia Journal of Human Rights (forthcoming).The Convention on the Rights of People with Disabilities and its Implications for the Rights of Elderly People Under International Law, 25 Georgia State U. L. Rev. 873 (2009).
Permanency Planning for Children with Disabilities: Ensuring the Right of Every Child to Live with A Family, 28 Children's Legal Rights Journal 1 (2008) (Journal of the American Bar Association Center on Children and the Law) (lead article).The Promise and Challenge of the United Nations Convention on the Rights of Persons with Disabilities, 34 Syracuse Journal of International Law and Commerce 287 (2007)The Right of People with Disabilities to Exercise Their Right to Vote under The Help America Vote Act, 30 Mental and physical disability law reporter 852 (with R. Russo) (2006). Ethics in Externships: Confidentiality, Conflicts and Competence, 10 CLINICAL LAW REVIEW 473 (with A. Anderson and C. Slane), (lead article, 2004). (Recognized as one of the top ten downloaded articles from the SSRN Legal Studies Research Journal).
The Globalization of Disability Rights Law, 30 SYRACUSE JOURNAL OF INTERNATIONAL LAW & COMMERCE 243 (2003).People with Disabilities Need an International Convention. Op Ed in SYRACUSE POST STANDARD, June 25, 2003.The Presumption Against Extraterritoriality As Applied to Disability Discrimination Laws: Where Does it Leave Students with Disabilities Studying Abroad? 14 STANFORD L. AND POL. REV. 291(2003).
The Need for Representation of People with Disabilities in Immigration Proceedings), 25 MENTAL AND PHYSICAL DISABILITY L. RPTR. 511 (with C. Nugent and C. B. Chisam) (2002).
Involuntary Outpatient Commitment in Israel: Treatment or Control? 24 INTERNATIONAL JOURNAL OF LAW AND PSYCHIATRY 637 (with M. Ajzenstadt, U. Aviram, M. Kalian) (2001).
The Right To Asylum for People with Disabilities 73 TEMPLE U. L. REV. 1117 (with K. Dadey) (2000).
Introduction to the Human Rights Symposium on The Concept of Human Rights and Its Application to Africa, 26 SYRACUSE JOURNAL OF INTERNATIONAL LAW & COMMERCE (Spring 1999).
Involuntary Outpatient Commitment in Israel, MISHPATIM (1998-99) (in Hebrew) (with U. Aviram and M. Ajzenstadt) (1998-99).
Israel's Involuntary Outpatient Commitment Law: Lessons from the American Experience, 29 THE ISRAEL L. REV. 565 (with U. Aviram) (1995).
A Home of One's Own: An Analysis of the Fair Housing Amendments Act of 1988 and Access to Housing for People with Mental Disabilities, 43 AMERICAN U. L. REV. 925 (1994).
Abandoned But Not Forgotten: The Rights of Elderly People in State Psychiatric Institutions, 19 N.Y.U. REV. OF L. AND SOC. CHANGE 273 (1992).
Homeless But Not Helpless: Legal Issues in the Care of Homeless People with Mental Illness, 45 JOURNAL OF SOCIAL ISSUES 91 (Winter 1989).
Advocating for Freedom: The Community Placement of Elders From State Psychiatric Hospitals, co-authored with Elizabeth Jones, 1989 CLEARINGHOUSE REVIEW 444 (1989).
Zoning, Real Estate and Related Issues, Presidential Committee on Mental Retardation, Washington, D.C., paper published in conference proceedings (February 1988).Legal Barriers to Access: The Unmet Health Care Needs of Homeless People, paper commissioned by the Institute of Medicine, National Academy of Sciences, Washington, D.C. (May 1987).
Homeless Mentally Ill People: No Longer Out of Sight and Out of Mind, 3 HUMAN RIGHTS ANN. 331 (1986).
Recent Zoning Cases Uphold the Establishment of Group Homes for the Mentally Retarded, 18 CLEARINGHOUSE REVIEW 515 (1984).
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text: The wife is still in the hospital, but she has the movement of all her limbs. Her speech is still slurred, but the Dr.'s agree that with therapy she will be back at pre-stroke condition. They said there is different levels of strokes and this was a mild one. And I'm convinced that the prayers from family and friends helped make it that way. Thanks again for all your support.


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Expired Property Listing
This property is disabled.
37200 Wildberry Close in Sea Ranch
- bedrooms 2
- baths 2
- sleeps 5
- pool yes
- hot tub yes
- pets allowed yes
- type House
- community
rates (USD)
/ week
vacation rental description
Cute little cottage in the meadow near the large recreation center.
Great ocean view! Large natural rock fireplace in living room. Light,
spacious kitchen. Hot tub in private fenced yard. Ladder loft for
extra sleeping.
house rental amenities
Beds available in the unit:... 1 Queen bed and 1 Twin bed in master
bedroom, 1 Double bed in 2nd BR and 1 Twin mattress in loft
Great Kitchen, washer/dryer,spa, fireplace, loft. Great view.
activities and attractions in Sea Ranch North Coast
Rec Center offers swimming, tennis, and saunas. There are miles of
well marked trails for hiking, bicycling and horses. There are
children playground area including swings, slides, volleyball.
Beaches within walking distance.
vacation rental rates
The rents listed below represent normal low-season rates including
taxes and after departure cleaning. Some homes have variable rates
based on the number of occupants. All rates are 10% higher during the
months of July and August and during Labor Day, Memorial Day,
Thanksgiving, Christmas and New Years Holidays. Rates are also
affected from time to time by special promotions. In addition to the
rent, you will pay a refundable security deposit (usually $200.00)
and non-refundable processing fee of $25.00. Your reservation agent
will explain your charges in detail.
Maximum guests:... 6 2 night rental:... $464.12 7 night rental:...


text:
Updated Dec 19, 2012 - 6:35 pm
Wreckage of small plane found in northern Arizona
Originally published: Dec 19, 2012 - 7:21 am
PAYSON, Ariz. -- Authorities say wreckage spotted in a mountainous area in northern Arizona is that of a small plane reported missing on a flight from Show Low to Payson.
A state Department of Public Safety helicopter spotted the wreckage about 10 a.m. Wednesday in the Mazatzal Wildnerness area around the 7,000-foot level.
Gila County Sheriff's officials say pilot David Kappes was found dead in the snow-covered wreckage. His age and hometown wasn't immediately released Wednesday night.
Federal Aviation Administration spokesman Ian Gregor says the pilot of the twin-engine Piper PA31 radioed air traffic controllers that he was diverting to Phoenix because of bad weather near Payson on Tuesday night.
Controllers lost radio and radar contact with the plane when it was about 50 miles east of Phoenix at about 8:30 p.m. Tuesday.


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PREMIUMSHOP – RESPONSIVE PRESTASHOP THEMEPremiumshop is an e-commerce theme created by Boxpixel. It has a High-tech & Trendy design for your store. We created the Premiumshop v2.1 from Original version of prestashop v184.108.40.206 & v184.108.40.206 We have created an advanced Theme controller module for Premiumshop.
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The Product Detail page have Advanced Search module, It will be very useful for your visitors to find the products by Price, Categories, Colors, Availability, Weight, Brands
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Prestashop Compatibility : v220.127.116.11 to v18.104.22.168+
Browsers Compatibility : Firefox, Safari, IE8, IE9, Chrome, Opera
UpdatesDo not forget to update your theme! Download the .zip file from your themeforest account downloaded history and replace the old files with the new ones provided.
12-02-2014Product Combination issue fixed
Jqzoom & Image enlarge issue fixed
Advertising block "Adblock plugin issue" solved
21-01-2014Version Updated: v22.214.171.124
Fixed: Best Seller page Issues
updated: product page page Issues
19-12-2013Version Updated: v184.108.40.206
11-11-2013Version Updated: v188.8.131.52
Updated to responsive
Updated Theme control module
Hover image for product images
List and grid view on category page
Advertisement banner updated
Footer module changed to suit responsive


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Some of our most important drugs were discovered partly by accident. Penicillin was developed after Alexander Fleming found a mold devouring the bacteria he was growing in a petri dish. A class of valuable blood pressure medications called ACE inhibitors... (Read More)
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Home Remedies
Q. My husband and I can't use KY Jelly or any other brand of lubricant we have tried. They make me itch and burn. We have found, though, that the slimy gel that oozes from aloe leaf when you break... (Read More)
Q. I struggled with a condition called angular cheilitis for 60 years. From the time I was five years old until two years ago I had redness, irritation and cracks at the corners of my mouth. When my family doctor... (Read More)
This is one of the tastiest and most unusual home remedies we have ever collected. Donald Agar had suffered from Crohn's disease for many years. Diarrhea was a constant problem. By accident he discovered that Archway Coconut Macaroon cookies helped... (Read More)
Pediatrician Alan Greene discusses his thoughts on the safety and efficacy of using hand sanitizers for children to prevent colds and the flu. --------... (Read More)
When we read about this treatment for alopecia areata in the Archives of Dermatology (November 1998) we were astounded. The Scottish dermatologists stated that "Cedarwood, lavender, thyme, and rosemary oils have hair growth-promoting properties. These oils have been anecdotally used... (Read More)
This is one of the most bizarre discoveries we have ever heard about. A scientist noticed that when he got up out of his chair after watching a football game, his arthritis pain was greatly diminished. During the course of... (Read More)
A reader shared with us his novel approach for treating arthritis with a Aspertame (also known by the brand name NutraSweet®) and Equal. -------- I was surprised to read a letter in your column from a diabetic who gets headaches... (Read More)
Q. When I first developed hemorrhoids I could hardly believe this was happening to me. I called my doctor and she suggested surgery, but I didn't want to go under the knife. A favorite book about foods that heal suggested... (Read More)
Warts are extremely susceptible to home remedies, and many have been developed for this common condition. One of our favorites is readily available at any grocery store. Tape a small piece of banana skin (with the fleshy side towards the... (Read More)
Q. Your readers did it again! I've been drinking oolong tea for over a month now, and the patches of psoriasis have disappeared along with the flaking. I still have a couple of areas that need some ointment now and... (Read More)
Doctors love scientific explanations for how things work. That is why they are quick to prescribe medications for a variety of conditions. FDA approval provides reassuring evidence of effectiveness. Dietary supplements, herbs and home remedies rarely have scientific support and... (Read More)
Thanks to Nell Heard and Wendall Dean for this contribution. Wendall is a wood-carver and scroller. His carving buddies always keep a packet of black pepper on hand for times when they cut themselves on sharp tools. Nell, her sister,... (Read More)
Q. I have suffered from bursitis in my right hip for about four years. I had six cortisone shots in my hip during this time. The first shots helped a lot, but the later ones did virtually nothing. I started... (Read More)
Q. I have a friend who says that Preparation H can smooth wrinkles on your face. She has lovely skin, but I am dubious. Could a hemorrhoid product really do any good against wrinkles, or is this an urban legend?... (Read More)
Q. Here is a home remedy for you. I got bitten by fire ants yesterday, and the bites swelled up and itched like crazy. I applied castor oil right away, and the itching stopped. The bites are just a little... (Read More)
Q. Have you ever heard of using castor oil for bruises? My mother-in-law swears by this remedy. Whenever one of my kids bumps a knee, she rubs castor oil on it and there is never a bruise. A. Arnica... (Read More)
Q. My cat was attacked by two pit bulls. Her abdomen was extremely swollen and she had two severe puncture wounds. We live on an island and the vet was out of town for a week. His advice to us... (Read More)
Q. I was amused to read about catnip as a mosquito repellent. A couple of summers ago I grew my own catnip (in hanging pots to keep it out of reach of the neighborhood cats) and followed a recipe for... (Read More)
Q. Recently you discussed how to avoid ticks and other creepy-crawlies in the summer. Some studies show that catnip oil is as good as DEET in repelling mosquitoes, and geranium oil likewise is effective for ticks. I use a combination... (Read More)
A competetive sprinter in his eighties shares his favorite home remedy for treating arthritis pain. --------... (Read More)
Q. I'm a 39-year-old woman in need of an herb that can decrease sex drive. I think you've written about this before, but I can't recall the herb you suggested. I'm in excellent health, taking only Flonase, Ortho Tri-Cyclen and... (Read More)
Q. I have been battling gout for the past five weeks and was on indomethacin, ibuprofen and a low purine diet. The attacks kept moving around from joint to joint, and the ordeal has been extremely painful. I heard that... (Read More)
This home remedy for curing hiccups sounds delicious. --------... (Read More)
Q. I have a home remedy that is amazing. I used to have severe psoriasis on my knees, elbows, eyes, forehead, wrists, feet and scalp. It would crack and bleed, itch and flake. One day a man commented on my... (Read More)
Q. I honestly hate the taste of cinnamon, although my husband loves it in cookies, cakes or anything else. I am 53 and was diagnosed with type 2 diabetes almost four years ago. My doctor has me on metformin twice... (Read More)
Cinnamon has been proven to help lower blood sugar, and can be helpful for people with type 2 Diabetes trying to manage their blood sugar. --------... (Read More)
Q. I heard about eating coconut macaroons to help with irritable bowel syndrome on your radio program. Our dog was having trouble with recurrent bouts of diarrhea and the vet could not find a reason. I gave her coconut flakes... (Read More)
Q. I believe Archway Coconut Macaroons help my IBS [irritable bowel syndrome], but as a diabetic I don't want the sugar. Do you know why they help? In other words, could I just eat unsweetened coconut? I called Archway Cookies... (Read More)
Asthma can be a serious disease that requires medical management, not home remedies. But we mentioned in the first edition of "The People's Pharmacy®" that if you are caught without medicine, a couple of cups of strong coffee may help... (Read More)
Q. For about 15 years, I've gotten an ugly cold sore on my upper lip at the end of the summer. It is always painful, and it takes at least a month to heal. The remedies I tried didn't help... (Read More)
Q. Sorry to repeat a question I know you've answered, but at the time I didn't know someone with the problem. My niece has recently been diagnosed with Crohn's disease and in spite of medication is in a lot of... (Read More)
Vaginal dryness is a common problem after menopause or certain cancer treatments. Finding an acceptable sexual lubricant can be a challenge. We heard from one couple who used an old-fashioned moisturizing hand lotion called Corn Huskers for twenty-five years. They... (Read More)
Q. I remember reading in one of your columns that soaking your toes in corn meal will get rid of toenail fungus. I have very bad toe fungus from years of competitive tennis and I would love to get rid... (Read More)
This listener shares her experience of using a home remedy consisting of cornmeal paste to cure her nail fungus. --------... (Read More)
Q. Our family has had several bouts of respiratory infections this fall. Our 5-year-old daughter is still coughing through the night and keeping everyone awake. We tried over-the-counter cough remedies but they didn't make much difference. My wife worries they... (Read More)
Q. Your column about using sugar on wounds has changed the way I treat the cattle on my ranch. We have nearly replaced tetracycline powder for cattle hoof abscesses and lesions. We did a test and saw equal results with... (Read More)
Q. The secret for lowering my hubby's cholesterol about 100 points was to eliminate all unnatural oils. I wouldn't allow him to take the medications. I'd been brainwashed about using vegetable oils years ago and they made his cholesterol numbers... (Read More)
Q. I have high blood pressure (about 180/80) and my doctor has prescribed nearly everything he can think of. We have tried over a dozen different medicines, with unacceptable results or side effects. I am currently taking Diovan which makes... (Read More)
Q. I am suffering terribly with eczema, aka atopic dermatitis. That's what my dermatologist calls my dry, red, itchy nasty skin. The doctor thought I might have an infection as well, and I have tried Bactroban antibiotic ointment as well... (Read More)
Research on duct tape was published in the Archives of Pediatric and Adolescent Medicine (Oct. 2002). Parents were told to cover the wart with a piece of duct tape for six days. If it fell off, they were to replace... (Read More)
Q. I suffer terribly from ear pain when flying. I take the decongestant pseudoephedrine, chew gum and blow my nose but none of these strategies is working any more to relieve the pressure. Do you have any recommendations? A. Over... (Read More)
It is estimated that almost two-thirds of American adults are infected with the virus that causes cold sores or fever blisters. A red lesion on the lip or near the mouth can be embarrassing and painful. People seem to stare... (More On This Topic)
Home remedies rarely get scientific attention or respect. The lack of double-blind trials means that it can be difficult to determine whether a specific suggestion will be helpful. Sometimes we get enough testimonials about a remedy, though, that we conclude... (Read More)
Q. I am 17 years old and was recently diagnosed with osteoporosis due to anorexia. I am hesitant to start taking a drug for osteoporosis because it seems that it can have bad side effects. Have you heard about any... (Read More)
Q. I have found that elderberry extract really helps against the common cold. If I start taking it soon enough I can keep the cold from getting a foothold. A. German researchers have found that a standardized elderberry extract is... (Read More)
Q. Three nights ago I was awakened by a feeling of the room whirling around. Ever since then, I cannot bend down or turn my head without vertigo and I have vomited as well. I have taken Bonine but it... (Read More)
We have received numerous solutions for flatulence, but this one seems the most popular. A physician's wife wrote to tell us that her husband's serious gas problem was solved when he followed this advice from a Hungarian masseuse: 1 tablespoon... (Read More)
This is the time of year that fungi thrive. Heat and humidity are the lifeblood for mold and mildew. Just check your shower curtain or the crawl space under your house in August to see signs of fungal growth. Your... (Read More)
Flaxseed is rich in soluble fiber. One reader has found a way to utilize this property to prevent constipation: "I purchase flaxseed in bulk at a health food store for about $1.50 per pound. I put three quarts of water... (Read More)
Q. I want to pass along a tip that I've been using for 20 years. I put about 2 teaspoons of cinnamon in my coffee filter and then put coffee grounds on top. I get the benefits of the cinnamon... (Read More)
We have received more mail about this "raisin remedy" than any other home remedy we have written about. We don't know how it got started or why it works, but many readers swear it relieves arthritis pain. Ingredients: golden raisins... (Read More)
We love this remedy and use it whenever we feel a cold coming on.It came to us from a radio listener in the hills of West Virginia but originated with her grandmother in India. Grind about half an inch of... (Read More)
One listener shares his experience using ginger to treat the symptoms of the common cold. Ginger is well known for its beneficial effects on the digestvie tract, but can also ease coughs and colds. --------... (Read More)
This is a lovely story from a retired nurse describing one of our favorite home remedies for treating arthritis. --------... (Read More)
Dermatologist Amy Wechsler talks with us about hair loss, including treating hair loss in women. --------... (Read More)
Q. Ice cream works very well against my migraines. I have suffered from these headaches for ten years and nothing has offered relief, not even strong painkillers. After reading that ice cream could help, I tried it. It relieves a... (Read More)
Click the arrow to play audio file:
Conventional wisdom has it that people who suffer migraine headaches should avoid chocolate. But a trucker tells us that, for him, a chocolate milk shake eases the pain of a migraine as well as Imitrex does. It works even though... (Read More)
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There are many home remedies for headaches. In this sound clip, a listener to our radio show tells of a traditional West Indies headache remedy: the white pith from the inside of an orange peel. Click on the blue arrow... (Read More)
Bonus Interview: listen to an additional interview with our guest:
Heartburn is a consequence of stomach acid splashing back into the lower part of the esophagus, where it causes damage and pain. Many people have shared their unusual home remedies for heartburn, from grated apple or a handful of almonds... (Read More)
Q. Several months ago I went to the ER because of severe chest pain. I thought I was having a heart attack. After some tests they told me it was heartburn. My highly respected naturopathic doctor told me not to... (Read More)
Here's a remedy that goes back generations. We can't explain or vouch for it…but it has been popular for a long time to promote regularity. A reader shared the following : "I have always had problems with regularity and recently... (Read More)
Q. I have been using honey as an ointment to prevent and treat skin infections for years. Not only does it work for cuts and scrapes, but it also works on herpes cold sores, cutting down on the length and... (Read More)
Q. I was suffering from severe diabetes-induced osteomyelitis (bone infection with open ulcers) on my foot. I was prescribed Medihoney to treat the ulcer. This is a waxy sheet of honey that you cut to the size of the wound... (Read More)
Q. After reading comments regarding the hot pepper remedy for heartburn at PeoplesPharmacy.com, the scientist in me couldn't resist giving it a try. For several years I have taken omeprazole, ranitidine or antacids to combat occasional acid reflux, especially after... (Read More)
Hot peppers and spicy food like salsas could provide relief from the discomforts of Psoriasis. --------... (Read More)
Bonus Interview: listen to an additional interview with our guest:
One reader shares his story of using spicy hot gumbo soup to stop a migraine cold. --------... (Read More)
We discovered this technique in the book Dermatology: Diagnosis and Treatment* and have been using it ever since we wrote it up in the first edition of "The People's Pharmacy®." Moderate itching (the sort of thing you get from a... (Read More)
Dermatologist Amy Wechsler explains the efficacy of laser hair removal. --------... (Read More)
Pediatrician Alan Greene addresses some concerns about the safety of sunscreens for children, and discusses the safest ingredients to look for when choosing a sunscreen for children. --------... (Read More)
Q. The best tip I ever received for mosquito bites is to dab on hydrogen peroxide. I have very sensitive skin and bites used to get very swollen and itch for weeks. Now, I apply drugstore hydrogen peroxide and in... (Read More)
Q. A few years ago I was plagued with insomnia. I was exhausted, anxious and barely functional but never sleepy. Only sleeping pills knocked me out, but I hated the side effects. I read about vitamin D in your column.... (Read More)
Q. I fell on a tour in Central and South America and a woman rushed to my aid from her post at the jewelry store. She started packing dry instant coffee onto my mooshed-up shin, assuring me she was a... (Read More)
Pediatrician Alan Greene talks us through the most current thinking about the potential risk of Aspirin, Reye's Syndrome, and what the best options are for treating pain and fever in children. --------... (Read More)
Put orange juice (8 oz? unspecified) and a diced banana or peach into a 16 oz jar, cap tightly and shake. Then add 1/3 cup raw rolled oats and 1 Tablespoon ground flax meal. Cap once again, shake, let sit... (Read More)
Q. I want to thank you for saving me from a most embarrassing situation. I am president of a small corporation and we were making a pitch to an important client. I had been suffering from a cold for about... (Read More)
Q. My friend works as a cook in a Mexican restaurant. The other day he cut the tip of his finger pretty badly. No matter what he tried he couldn't stop the bleeding. He went to an urgent care center... (Read More)
A gentleman called in to our public radio show with an amazing story about Listerine mixed with baby oil. His veterinarian had recommended this combination for relieving itchy spots on his Dobermans and horses. He found that it worked and... (Read More)
A horse lover shared the following formula she used on the mane and tail of her filly: 1/3 Listerine (original formula) 1/3 baby oil and 1/3 water Put in a spray bottle, shake well and spray it on. This is... (Read More)
We have heard from several readers that Listerine can be helpful in preventing lice infestations. We recently received this testimonial from a reader: "The best way to prevent head lice is old-fashioned Listerine Antiseptic Mouthrinse. We were in the Army... (Read More)
A reader offered the following suggestion for getting rid of nail fungus: "I cured my toenail fungus using a 50/50 mixture of vinegar and Listerine. I combined them in a quart jar with a screw-on lid and used a clean... (Read More)
The meat tenderizer trick was our very first home remedy in the original edition of The People's Pharmacy®.* We stumbled across it in the Journal of the American Medical Association.** Dr. Harry L. Arnold of the American Health Institute suggested... (Read More)
Q. I am in my late seventies, and my breasts are very large. In hot weather I used to have a serious problem with heat rash. Various creams and lotions didn't help much. Then I tried milk of magnesia, and... (Read More)
Q. My family has used milk of magnesia as a deodorant for 60 years since Cuba. That is what everyone used, even before the revolution. My family still uses it today in the United States, since it's better than any... (Read More)
Q. I walked all around the house for 10 minutes last night with a cramp in my ankle that wouldn't quit. Then I remembered my sister telling me to try mustard. I went to the refrigerator and got a dab... (Read More)
Q. I have scars on my arms and legs after a bad outbreak of poison ivy. Are there any natural remedies for scars? A. Dermatologists and plastic surgeons report that no single therapy has been proven effective for reducing scars... (Read More)
Q. Are there any natural approaches for the pain of neuropathy? A. There are two possibilities. One is alpha lipoic acid. A meta-analysis of 15 randomized controlled trials demonstrated that it is safe and probably effective for treating diabetic nerve... (Read More)
Q. For nearly 30 years I got "honeymoon cystitis" following intercourse. After menopause I learned from a TV show that women were using olive oil for postmenopausal vaginal dryness. I was pleasantly surprised that it not only assisted with lubrication... (Read More)
Q. My daughters both suffer from eczema. It's just heartbreaking. My older daughter had it on her hands starting when she was one. It was so bad that her skin started to bleed and crack, and her nails were brittle... (Read More)
Q. When I am sick with a cold I crave onions. I am not sure why and I don't know if they actually help me get over my cold any faster. I just read an article that is circulating on... (Read More)
Q. I have been plagued with nummular eczema for years. It does not respond to Benadryl, prednisone or any kind of topical cortisone ointment. I read in your column about some doctors in Japan who had people with eczema drink... (Read More)
A listener shares her own personal recipe and technique to make a Passion Flower extract to treat her husbands insomnia. --------... (Read More)
Q. I have had irritable bowel syndrome (IBS) for two years. I have constipation (can't "go" for a week). When I finally can go, I can't stop. At that point the stool is soft and runny. I also have cramps,... (Read More)
A listener to our radio show called in the following recipe his Philippine-American girlfriend taught him. He says eating this chicken once a week keeps colds away. We don't know about that, but it might keep everyone else away as... (Read More)
Q. I don't have restless leg syndrome (RLS) or nighttime leg cramps. Rather I have "restless foot," sometimes in the right foot, sometimes in the left. I can actually feel the energy building up in my foot when it comes... (Read More)
Q. After reading a column about turmeric for plantar warts, I began treating a very large wart that covered my entire heel. I am happy to report that it has stopped growing and is slowly healing. Thank you. A. Other... (Read More)
Pediatrician Alan Greene gives us his top three recommendations for pro-active ways to deal with Eczmea. --------... (Read More)
Recipe 1 cup applesauce 1 cup coarse, unprocessed bran 3/4 cup prune juice Mix all the ingredients together. They will turn into a pasty, stiff glop about the consistency of peanut butter. After mixing, it should be kept refrigerated. Take... (Read More)
This home remedy for arthritis pain has generated almost as much mail as the gin and raisins. One newspaper column reader related that her grandmother had been using it as long ago as 1945. Purchase Certo in the canning section... (Read More)
We roared with laughter when we read the letter from a woman who told us that her uncle's little terrier had cured his long-standing case of athlete's foot. Every evening when he got home, he would take off his shoes... (Read More)
One of the strangest remedies we have ever heard of involves sauerkraut juice against canker sores. Take a tablespoon of sauerkraut juice in your mouth and swish it around morning and night, then swallow it. Do this twice a day... (Read More)
Q. My sister is coming over in a week. I have dandruff on my face (eyebrows, nose, forehead and inside my ears). Can I cure it with Vicks or other remedies? Please tell me how. A. Facial dandruff is called... (Read More)
People use all sorts of remedies for bee or wasp stings. Some swear by tobacco juice, but that is getting hard to come by as the habit of chewing tobacco is fading (along with cigarette smoking). Others prefer mud or... (Read More)
Q. I recommend extra virgin coconut oil for vaginal dryness. It's a natural anti fungal and antibacterial. I use it a a sexual lubricant but also as a moisturizer for my face and neck. Stephanie A. We have heard from... (Read More)
Q. For several years now I have kept a bar of soap in my bed under the top sheet for leg cramps. I find that it works. For almost a year now, I have had severe nighttime pain in my... (Read More)
There is now a prescription drug (Requip) to treat RLS (restless leg syndrome). The only problem is that some people fall asleep during the day. This could be risky if they are behind the wheel. As far as we can... (Read More)
Q. Several years ago I read about the soy sauce remedy in The People's Pharmacy. Luckily we always have large quantities of soy sauce in the house. Since that day, any time I burn myself in the kitchen I immediately... (Read More)
An Airborne Ranger shares with us his experience of being burned during a training excercise, and what the Special Forces medic used to treat him might surprise you. --------... (Read More)
Q. I want to thank you for writing about warts on teenagers. My son had been battling warts for years, but burning, cutting and immune response methods had not worked. One wart on the back of his Achilles tendon was... (Read More)
Q. I have an old chemical burn on my shin that re-opened. The wound cultured positive for MRSA, so I took antibiotics for a month. Despite that, the wound continued to get worse and nothing seemed to help. I tried... (Read More)
Hiccups are rarely serious, but they certainly can be annoying. There are dozens of remedies from holding your breath to drinking water from the far side of a glass. This is one we have been talking about since 1976. It's... (Read More)
There are so many wart remedies it is hard to know where to start or stop. Castor oil applications are highly recommended by our readers. But one of the few treatments that have actually been tested is taking Tagamet. This... (Read More)
Sweaty hands can be embarrassing, and sweaty feet can lead to foot odor and increase the risk of athlete's foot. One dermatologist we consulted offered the following home remedy: Boil five tea bags in a quart of water for five... (Read More)
Q. I teach elementary school and lice are an ongoing frustrating problem. Many low-income families struggle with the high cost of treatments, which often are not effective. I have two suggestions that are natural and quite effective (given to me... (Read More)
Purple concord grape juice has some anti-clotting effects and can inhibit inflammatory compounds in the blood. It can also produce a modest increase in good HDL cholesterol. Dr. Jane Friedman at Boston University School of Medicine explains her study on... (Read More)
Q. I am very sensitive to mosquito bites, and mosquitoes LOVE me. If I get one bite, I have ten. A friend suggested a shot glass of tonic water each day. While she was on her honeymoon in a tropical... (Read More)
Dermatologist Amy Wechsler shares with us her advice on treating dry and chapped lips. She disusses what causes chapped lips, and what to avoid to prevent becoming dependent on lip balm. --------... (Read More)
Dermatologist Dr. Amy Wechsler discusses with us the most effective ways to treat the excessive sweating known as Hyperhidrosis. --------... (Read More)
Dermatologist Amy Wechsler shares her tips for treating oily skin. --------... (Read More)
Dermatologist Amy Wechsler discusses with us her favorite ways to remove warts. --------... (Read More)
Turmeric and its most active ingredient curcumin have gotten attention for their anti-inflammatory properties. We have heard from readers that this yellow spice used in curry powder and mustard can help alleviate arthritis pain. One reader offered the following experience.... (Read More)
A radio listener shares her stepfather's experience with Turmeric for his severe Psoriasis. --------... (Read More)
The People's Pharmacy® radio show is made possible in part by Redex Industries, makers of Udder Cream, Udderly Smooth Hand and Body Lotion, and the new COUNTRY CREAM.aids for dry, chapped skin. 800-345-7339 . The website is: http://www.uddercream.com... (Read More)
Pediatrician Alan Greene dicusses some unique ways to treat head lice without using harsh pesticides. --------... (Read More)
Q. I had problems with cracked, calloused soles and toenail fungus. I had medicine but it did not go very far. One of the items in the medicine was urea, which I believe is a by-product of urine. I started... (Read More)
Q. I just read in one of your emails that someone used "Organic Apple Cider Vinegar" for their scalp psoriasis. I owe that person big time for writing in!!! Do I dare say that it is the best thing I... (Read More)
Anyone who has ever had to give a talk in front of a large audience knows that anxiety can be paralyzing. One woman had to give up a career as a musician because her stage fright was incapacitating. Even after... (Read More)
This home remedy has gotten us into a lot of trouble. In recent years lice have seemingly become resistant to over-the-counter lice shampoos, which has left families desperate for relief. One mother wrote that a pediatric dermatologist, Neil Prose, M.D.,... (Read More)
If you click on the white arrow above you will hear an interesting story from Jane, a foot care nurse in Massachusetts. She travels the state taking care of patients with diabetes and other conditions that create all sorts of... (Read More)
One listener shares her experience of using Vicks® VapoRub® in a novel way to treat her severe and chronic cough. --------... (Read More)
People who suffer from vertigo often feel desperate. If the problem is benign paroxysmal positional vertigo, the world seems to spin any time they move their heads. It is extremely uncomfortable, even disorienting. BPPV is caused when calcium crystals in... (Read More)
There are so many uses for vinegar it boggles the mind. An otolaryngologist (ear, nose, and throat specialist) recommended rinsing the ear with the following solution: one part vinegar to five parts tepid water. He suggested putting drops in the... (Read More)
Almost all antiperspirants contain aluminum, in one form or another. It is hard to say at this time whether we absorb any of that aluminum into our systems and even if we did, whether it would be harmful. Nonetheless, some... (Read More)
Q. I use milk of magnesia as a deodorant but first I apply a spray of vodka under my arms. Using vodka to fight body odor is no recent discovery. Theatrical wardrobe professionals going back to vaudeville days have used... (Read More)
Here is another doctor-recommended home remedy. Russell Copelan, M.D., wrote about this one in the Journal of the American Academy of Dermatology.* He suggests adhering a tiny piece of salicylic acid plaster (the kind used to treat warts) over a... (Read More)
Dermatologist Amy Wechsler tells us about some warning signs that should send you to see a dermatologist right away. --------... (Read More)
Q. You have written several times about putting yellow mustard on a burn for relief. Thank goodness I have known about this emergency approach for more than 30 years. About eight years ago, when my twin girls were three years... (Read More)


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The definition of insanity is doing the same thing over and over again, expecting different results. To make your website stand out, you have to stay up to date with the web rate of change. Relying on the same old approaches to your website content management won't work.
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CALGARY, Alberta (AP) -- Loui Eriksson had a short-handed goal and added an assist in regulation, then scored in a shootout in the Dallas Stars' 3-2 victory over the Calgary Flames on Sunday night.
Jamie Benn scored on Dallas' first attempt in the shootout, and Eriksson connected on the second.
Michael Ryder added a power-play goal, and Kari Lehtonen made 36 saves and assisted on Eriksson's goal. The Stars have climbed to seventh in the Western Conference, going 6-0-1 in their last seven games.
Curtis Glencross and Jarome Iginla scored for Calgary. The Flames have lost two straight and three of their past four.


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High tech, low tech face off at 25th ICFF
The 25th edition of the International Contemporary Furniture Fair here was marked by a distinctive contradiction between high and low: tech, that is. Recent advances in technology resulted in cutting-edge creations utilizing 3D printing as well as LED applications - not just for lighting but also for innovative wall décor, furniture and more.
Posted: June 17, 2013


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Cytochrome c oxidase
|Cytochrome c oxidase
|EC number
|CAS number
|IntEnz view
|BRENDA entry
|NiceZyme view
|KEGG entry
|metabolic pathway
|PDB structures
|RCSB PDB PDBe PDBsum
|Gene Ontology
|AmiGO / EGO
The enzyme cytochrome c oxidase or Complex IV, EC 18.104.22.168) is a large transmembrane protein complex found in bacteria and the mitochondrion of eukaryotes.
It is the last enzyme in the respiratory electron transport chain of mitochondria (or bacteria) located in the mitochondrial (or bacterial) membrane. It receives an electron from each of four cytochrome c molecules, and transfers them to one oxygen molecule, converting molecular oxygen to two molecules of water. In the process, it binds four protons from the inner aqueous phase to make water, and in addition translocates four protons across the membrane, helping to establish a transmembrane difference of proton electrochemical potential that the ATP synthase then uses to synthesize ATP.
The complex is a large integral membrane protein composed of several metal prosthetic sites and 14 [1] protein subunits in mammals. In mammals, eleven subunits are nuclear in origin, and three are synthesized in the mitochondria. The complex contains two hemes, a cytochrome a and cytochrome a3, and two copper centers, the CuA and CuB centers.[2] In fact, the cytochrome a3 and CuB form a binuclear center that is the site of oxygen reduction. Cytochrome c, which is reduced by the preceding component of the respiratory chain (cytochrome bc1 complex, complex III), docks near the CuA binuclear center and passes an electron to it, being oxidized back to cytochrome c containing Fe3+. The reduced CuA binuclear center now passes an electron on to cytochrome a, which in turn passes an electron on to the cytochrome a3-CuB binuclear center. The two metal ions in this binuclear center are 4.5 Å apart and coordinate a hydroxide ion in the fully oxidized state.
Crystallographic studies of cytochrome c oxidase show an unusual post-translational modification, linking C6 of Tyr(244) and the ε-N of His(240) (bovine enzyme numbering). It plays a vital role in enabling the cytochrome a3- CuB binuclear center to accept four electrons in reducing molecular oxygen to water. The mechanism of reduction was formerly thought to involve a peroxide intermediate, which was believed to lead to superoxide production. However, the currently accepted mechanism involves a rapid four-electron reduction involving immediate oxygen-oxygen bond cleavage, avoiding any intermediate likely to form superoxide.[3]
Site of assembly is believed to occur near TOM/TIM, where complex intermediates are accessible to bind with subunits imported from cytosol. Hemes and cofactors are inserted into subunits I & II. Subunits I and IV initiate assembly. Other subunits may form sub-complex intermediates that later bind to others to form COX complex. In post-assembly modifications, the enzyme is dimerized, which is required for active/efficient enzyme action. Dimers are connected by a cardiolipin molecule.[4][5]
Summary reaction:
- 4 Fe2+-cytochrome c + 8 H+in + O2 → 4 Fe3+-cytochrome c + 2 H2O + 4 H+out
Two electrons are passed from two cytochrome c's, through the CuA and cytochrome a sites to the cytochrome a3- CuB binuclear center, reducing the metals to the Fe2+ form and Cu+. The hydroxide ligand is protonated and lost as water, creating a void between the metals that is filled by O2. The oxygen is rapidly reduced, with two electrons coming from the Fe2+cytochrome a3, which is converted to the ferryl oxo form (Fe4+=O). The oxygen atom close to CuB picks up one electron from Cu+, and a second electron and a proton from the hydroxyl of Tyr(244), which becomes a tyrosyl radical: The second oxygen is converted to a hydroxide ion by picking up two electrons and a proton. A third electron arising from another cytochrome c is passed through the first two electron carriers to the cytochrome a3- CuB binuclear center, and this electron and two protons convert the tyrosyl radical back to Tyr, and the hydroxide bound to CuB2+ to a water molecule. The fourth electron from another cytochrome c flows through CuA and cytochrome a to the cytochrome a3- CuB binuclear center, reducing the Fe4+=O to Fe3+, with the oxygen atom picking up a proton simultaneously, regenerating this oxygen as a hydroxide ion coordinated in the middle of the cytochrome a3- CuB center as it was at the start of this cycle. The net process is that four reduced cytochrome c's are used, along with 4 protons, to reduce O2 to two water molecules.
Cyanide, sulfide, azide, and carbon monoxide[6] all bind to cytochrome c oxidase, thus competitively inhibiting the protein from functioning, which results in chemical asphyxiation of cells. Methanol in methylated spirits is converted into formic acid, which also inhibits the same oxidase system.
Subcellular Localization and Presence at Extramitochondrial Sites[edit]
Cytochrome c oxidase has 3 subunits which are encoded by mitochondrial DNA. Of these 3 subunits encoded by mitochondrial DNA, two have been identified in extramitochondrial locations. In pancreatic acinar tissue, these subunits were found in zymogen granules. Additionally, in the anterior pituitary, relatively high amounts of these subunits were found in growth hormone secretory granules.[7] The extramitochondrial function of these cytochrome c oxidase subunits has not yet been characterized. Besides cytochrome c oxidase subunits, extramitochondrial localization has also been observed for large numbers of other mitochondrial proteins.,[8][9] This raises the possibility about existence of yet unidentified specific mechanisms for protein translocation from mitochondria to other cellular destinations.[7][9][10]
Genetic defects and disorders[edit]
Defects involving genetic mutations altering cytochrome c oxidase (COX) functionality or structure can result in severe, often fatal metabolic disorders. Such disorders usually manifest in early childhood and affect predominantly tissues with high energy demands (brain, heart, muscle). Among the many classified mitochondrial diseases, those involving dysfunctional COX assembly are thought to be the most severe.[11]
The vast majority of COX disorders are linked to mutations in nuclear-encoded proteins referred to as assembly factors, or assembly proteins. These assembly factors contribute to COX structure and functionality, and are involved in several essential processes, including transcription and translation of mitochondrion-encoded subunits, processing of preproteins and membrane insertion, and cofactor biosynthesis and incorporation.[12]
Currently, mutations have been identified in seven COX assembly factors: SURF1, SCO1, SCO2, COX10, COX15, COX20, COA5 and LRPPRC. Mutations in these proteins can result in altered functionality of sub-complex assembly, copper transport, or translational regulation. Each gene mutation is associated with the etiology of a specific disease, with some having implications in multiple disorders. Disorders involving dysfunctional COX assembly via gene mutations include Leigh syndrome, cardiomyopathy, leukodystrophy, anemia, and sensorineural deafness.
COX histochemistry is used for mapping regional brain metabolism in animals, since there is a direct relation between enzyme activity and neuronal activity.[13] Such brain mapping has been accomplished in spontaneous mutant mice with cerebellar disease such as reeler[14] and a transgenic model of Alzheimer's disease.[15] This technique has also been used to map learning activity in animal brain.[16]
Additional images[edit]
See also[edit]
- Cytochrome c oxidase subunit I
- Cytochrome c oxidase subunit II
- Cytochrome c oxidase subunit III
- Heme a
- ^ Balsa E, Marco R, Perales-Clemente E, Szklarczyk R, Calvo E, Landázuri MO, Enríquez JA (September 2012). "NDUFA4 is a subunit of complex IV of the mammalian electron transport chain". Cell Metab. 16 (3): 378–86. doi:10.1016/j.cmet.2012.07.015. PMID 22902835.
- ^ Tsukihara T, Aoyama H, Yamashita E, Tomizaki T, Yamaguchi H, Shinzawa-Itoh K, Nakashima R, Yaono R, Yoshikawa S (August 1995). "Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 A". Science 269 (5227): 1069–74. doi:10.1126/science.7652554. PMID 7652554.
- ^ Voet, Donald (2010). Biochemistry. New York: J. Wiley & Sons. pp. 865–866. ISBN 0-470-57095-4.
- ^ Khalimonchuk O, Rödel G (December 2005). "Biogenesis of cytochrome c oxidase". Mitochondrion 5 (6): 363–88. doi:10.1016/j.mito.2005.08.002. PMID 16199211.
- ^ Fontanesi F, Soto IC, Horn D, Barrientos A (December 2006). "Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular process". Am. J. Physiol., Cell Physiol. 291 (6): C1129–47. doi:10.1152/ajpcell.00233.2006. PMID 16760263.
- ^ Alonso JR, Cardellach F, López S, Casademont J, Miró O (September 2003). "Carbon monoxide specifically inhibits cytochrome c oxidase of human mitochondrial respiratory chain". Pharmacol. Toxicol. 93 (3): 142–6. doi:10.1034/j.1600-0773.2003.930306.x. PMID 12969439.
- ^ a b Sadacharan, S. K., Singh, B., Bowes, T. and Gupta, R. S. (2005). Localization of mitochondrial DNA encoded cytochrome c oxidase subunits I and II in rat pancreatic zymogen granules and pituitary growth hormone granules. Histochem Cell Biol. 124:409-421.
- ^ Gupta, R. S., Ramachandra, N. B., Bowes, T. and Singh, B. (2008) Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10. Novartis Found Symp. 291: 59-68.
- ^ a b Soltys, B. J. and Gupta, R. S. (1999). Mitochondrial proteins at unexpected cellular locations: export of proteins from mitochondria from an evolutionary perspective. International Review of Cytology. 94:133-196.
- ^ Soltys , B. J. and Gupta, R.S. (1999) Mitochondrial proteins at unexpected locations: Are they exported?" Trends Biochem. Sci 24: 174-177.
- ^ Pecina P, Houstková H, Hansíková H, Zeman J, Houstek J (2004). "Genetic defects of cytochrome c oxidase assembly". Physiol Res. 53 Suppl 1: S213–23. PMID 15119951.
- ^ Zee JM, Glerum DM (December 2006). "Defects in cytochrome oxidase assembly in humans: lessons from yeast". Biochem. Cell Biol. 84 (6): 859–69. doi:10.1139/o06-201. PMID 17215873.
- ^ Wong-Riley MT. (1989). "Cytochrome oxidase: an endogenous metabolic marker for neuronal activity.". Trends Neurosci. 12 (3): 94–111. doi:10.1016/0166-2236(89)90165-3. PMID 2469224.
- ^ Strazielle C, Hayzoun K, Derer M, Mariani J, Lalonde R. (April 2006). "Regional brain variations of cytochrome oxidase activity in Relnrl-orl mutant mice.". J. Neurosci. Res. 83 (5): 821–31. doi:10.1002/jnr.20772. PMID 16511878.
- ^ Strazielle C, Sturchler-Pierrat C, Staufenbiel M, Lalonde R. (2003). "Regional brain cytochrome oxidase activity in beta-amyloid precursor protein transgenic mice with the Swedish mutation.". Neuroscience 118 (4): 1151–63. doi:10.1016/S0306-4522(03)00037-X. PMID 12732258.
- ^ Conejo NM, González-Pardo H, Gonzalez-Lima F, Arias JL. (2010). "Spatial learning of the water maze: progression of brain circuits mapped with cytochrome oxidase histochemistry.". Neurobiol. Learn. Mem. 93 (3): 362–71. doi:10.1016/j.nlm.2009.12.002. PMID 19969098.
External links[edit]
- The Cytochrome Oxidase home page at Rice University
- Interactive Molecular model of cytochrome c oxidase (Requires MDL Chime)
- UMich Orientation of Proteins in Membranes families/superfamily-4
- Cytochrome-c Oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)


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FootprintWire 14.9.12
Today's green news: British artist Morag Myerscough's pop-up Movement Cafe now open in Greenwich
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Click here for more information and past shows!
Rebecca Pronsky
Rebecca Pronsky is a born and raised Brooklynite who plays twangy folk that is "as urban as it is rural, not afraid to be sophisticated" (Maverick). "Pronsky's voice conveys the wisdom of experience" (NPR) and her live performances are "passionate and wry" (Time Out NY). Only Daughter, Rebecca's newest album, will be released in March 2013. Her most adventurous work yet, the album is gritty and noir-ish, layered and dreamy, bravely disobeying the usual conventions of the Americana genre.
Nels Andrews
"Where has this guy been hiding? In the library, maybe." (Jim Blum, NPR's Folk Alley, Best of 2012)
Nels Andrews has spent the last decade wandering, gathering songs, and singing them all over the globe, sharing them around campfires, coffee shops, clubs , festivals, and living room floors. Critically, he's struck a nerve, earning songwriting awards from prestigious US festivals such as Kerrville, Telluride, and Mountain Stage. His latest record Scrimshaw, tells stories culled from a time off the road, working as a chauffeur in Manhattan.
Penny Nichols
Penny Nichols is an award winning, 3-time Grammy nominated singer/songwriter and vocal arranger who has been performing and teaching since 1966. Her most recent ventures include a new CD of songs by old friend Jackson Browne, Colors of the Sun: The Early Songs of Jackson Browne, her book/CD: The 8 Voyages of Nep, teaching at Colorado Roots Music Camp, SAMW folk camp in New Hampshire and Moab Folk camp in Utah and being the founding director of the non-profit SummerSongs, Inc., which is going into its 14th year of music camps for songwriters.