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Michael Connelly, MD
Nothing is more basic in medicine than the desire to treat pain, but major change is needed in how prescription pain medications are managed, and this topic is increasingly in the news.
To address these needed changes, the Massachusetts Board of Registration in Medicine now requires doctors to earn education credits on prescribing opioid medication. And the Massachusetts Legislature recently considered mandating physicians to check patient information in a prescription database before prescribing pain medication. But how did we get to this point?
During the 1990s, there was a strong effort to improve pain treatment. Hospitals were directed to record pain as the fifth vital sign, and the specialty of pain medicine grew through fellowship training programs that resulted in many doctors becoming board-certified pain specialists.
For the most part, this has been good news. We are better at treating pain during child birth and after surgery, and we now have excellent options for managing spinal pain. For example, a 10-minute procedure to place steroid medication on a painful nerve is effective for nearly two thirds of patients with a disc herniation.
But medicine made a wrong turn in the effort to treat pain by promoting more prescriptions for addictive opioid medication. This wrong turn resulted from the honest interest to improve pain treatment, combined with pharmaceutical companies promoting medications like Oxycontin.
An opioid is a medication that relieves pain by stimulating receptors in the brain and spinal cord that interfere with the transmission of pain signals. We are learning that there is a big difference between short-term pain, from a broken bone, for example, and ongoing chronic pain. Chronic pain is not well managed with opioid medication. Studies show pain continues with a very small reduction in pain scores.
A pain medication like Percocet not only turns down the pain signal, it also releases a chemical called dopamine deep in the brain. Dopamine causes us to feel good and this "feel good" response is the same response the body gets from heroin — the most addicting of opioids. Other highly addictive chemicals such as cocaine and nicotine cause a similar release of dopamine.
Though addiction is rare with short-term use, in the long term it can pose a major problem. After the release of dopamine, the brain creates more receptors for dopamine to enhance the response, and over time this may lead to addiction. Without the opioid, the dopamine receptors are empty, and empty dopamine receptors make us feel bad. The state of addiction is one where the opioid is taken just to feel normal. Without it, people feel they cannot function.
Death from prescription drug abuse — nearly 30,000 per year — is the second leading cause of accidental death in the United States. More people die from prescription drug abuse than from cocaine and heroin combined. The rapid increase has followed the increase in opioid prescriptions.
What can be done for chronic pain? The best approach is to seek a board certified pain specialist who evaluates patients for structural problems and looks more broadly at muscular conditioning, weight and stress. Treatment may involve injections, medications, physical rehabilitation, relaxation strategies for stress and medication for depression. There are limited roles for opioid medication, but based on the extent of abuse and number of deaths, a change is needed from current practice. We need more information to identify when it can be safe and effective.
• • •
Michael Connelly, MD, a board-certified pain specialist with New England Neurological Associates, is on staff at Merrimack Valley Hospital, a Steward family hospital. The Gazette regularly publishes columns by Merrimack Valley Hospital doctors.


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Delray Rocks taking football, cheerleading registrationMonday, May 3rd, 2010
The Delray Rocks Youth Football and Cheerleading program is taking registration for the fall season. The program is open to participants ages 6-15.
Cost is $65 per child through June 28, and $75 for Delray Beach residents and $80 for nonresidents June 29 through July 31. Register at Pompey Park, 1101 NW 2nd Street. Participants must bring a birth certificate, proof of guardianship and proof of residency.
Practice begins Aug. 2. Physicals are required for all participants.
For information, call (561) 243- 7356. Ben Leonard (football) or Julie Nixon (cheerleading).

subset: commoncrawl


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Naylor departs Accrington Stanley (From Lancashire Telegraph)
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Naylor departs Accrington Stanley
4:04pm Thursday 16th January 2014 in Football
ACCRINGTON Stanley have ended the contract of Lee Naylor by mutual consent.
The former Wolves, Celtic and Cardiff City left back had only signed a short-term contract with the Reds in an effort to revive his career and it is understood he has been the subject of interest from at least one League One club closer to his Midlands home.
"I've had a few long chats with Lee and the travelling has been really getting to him. He's had a bit of interest from higher league clubs and we decided to mutually terminate his contract," said Stanley boss James Beattie.
"We're sad to lose Lee with him being an experienced pro but we had a chat and were honest with each other. It's disappointing to lose a player of his quality but I understand totally where he's coming from.
"For the board it's another player off the wage bill but I'm not looking at it like that. I see it as us losing a player of top quality and we wish him all the best."
Beattie added that Naylor's exit presented an opportunity for players such as Michael Liddle and Laurence Wilson to stake their claim.
"They must have been disappointed when Lee came in and I would hope that they were," he said, adding: "The competition for places in the squad is healthy but we're always looking for additions whether the window is open or closed."
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Narrow your search
Looking for an e-book reader? You have more choices than ever before--though the number of models we
After the tech giant agrees to pay millions in the e-book price-fixing lawsuit, the presiding judge says, "I'm concerned about the terms of the settlement."
Scribd and Oyster's all-you-can-read e-book subscription services add 'Big 5' publisher's backlist titles.
In the battle to become the "Netflix of digital books," Scribd is taking its app to Amazon Kindle Fire tablets while updating its iOS and Android apps.
While it doesn't necessarily beat the Kindle Paperwhite, the $119 Nook GlowLight is an excellent e-reader that's strongly worth considering if you don't want to buy into the Amazon ecosystem.
On 3 December, Sony Japan will be launching the DPT-S1: a 13.3-inch E Ink reader for PDFs, aimed at the student market.
Whether you've got an avid reader on your list or are just looking for some page-turning recommendations, these e-books are sure to please.
Barnes & Noble's new e-ink e-reader costs the same ($119) as the Kindle PaperWhite, is lighter at 6.2 ounces, and has an improved lighting scheme.
Barnes & Noble's next-generation e-ink e-reader costs the same ($119) as Amazon's Kindle Paperwhite, is lighter at 6.2 ounces, and has an improved lighting scheme. Check out CNET's photos of the new device.
With its more portable design, the Kobo Aura is a worthwhile -- albeit pricier -- Kindle Paperwhite alternative for EPUB fans who don't want to be tied to Amazon's proprietary ecosystem.
In some ways, the Kobo Aura beats the Kindle Paperwhite.


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WHY DOESN'T AMERICA CELEBRATE HOPKINS?, Before the doping Armstrong was heraleded!!
WHY DOESN'T AMERICA CELEBRATE HOPKINS?, Before the doping Armstrong was heraleded!!
Mar 10 2013, 02:29 PM
Post #1
Junior Welterweight
Group: Members
Posts: 1,095
Joined: 20-June 12
From: UrANUS
Member No.: 13,708
America is very selective at best when it comes to who we pick and chose when it comes to making celebrities, if BHop was in any other country in the world he'd be on the cover of every magazine, box of cereal, doing all the commercials and an icon to their status as a proud nation.
But in the USA, Hopkins isn't celebrated, isn't given any or very little fanfare at all. I wish I knew the reasoning for this but I guess I'd have to ask you guys here to speculate as to why this is, Lance Armstrong prior to his downfall was The Man in his native land and the only person who stood par with him are Jordan and Pacquiao.
I have a few reasons why I believe he'd never get the status he deserves in the public's persona are the following:
1. Former Felon
2. Not considered by some to be an exciting fighter
3. Boxing as a whole isn't amongst the country's most embraced sports like Football
4. He's African American (not necessarily a racial thing here) but if he were White then I believe he'd get the fanfare because white America still longs for their GWH
5. He isn't exactly pleasing to the eye (looks), the missing teeth do not help
6. In the past some took the comment he made about Joe C "never let a white boy beat me" as a racial attack and they won't live it down/let it go
7. The powers that be doesn't want an old face to be the face of this sport, they prefer the young bruiser types like Tyson
Personally, I believe he should be given more credit for what he has done and continues to do because as far as I know there isn't another dominant champion in any other sport at his age that continues to be as defiant/at the top of their league and doing it against opposition nearly half their age.
Mar 14 2013, 12:56 PM
Post #2
Group: Banned
Posts: 1,729
Joined: 21-April 07
From: New York, New York
Member No.: 5,991
So who is it that he's is/was supposed to fight? You can make a case for many ATG's fighting far worse competition then him. He fights at 175 and he's beating belt holders and solid young champions. Cloud seems like a prospect to some, though not me. But blame that on his shitty promoter.
What he's done is something to truly marvel at and it will NEVER be done again and if by chance it does none of us will be around to see it. The man has 6 losses and truthfully only 3( his 1st pro fight, the 1st RJJ fight and the Dawson rematch) of the 6 can't be disputed
He's the greatest of his era of boxers. None of them could do what he's doing now. Not RJJ, not Toney, and definitely not Calzaghe
I hate to agree with a CHITOWN MOFO-- (IMG:style_emoticons/default/fuck.gif) but you are dead on LMAO!!! Floyd Mayweather is not the greatest of this era.. Hopkins is. I am sure RJJ keeps going because he says to himself, "Damned, Bernard's career is beginning to make mines look sub par"... LOL
This post has been edited by neophyte7: Mar 14 2013, 12:58 PM
|Lo-Fi Version
|Time is now: 23rd August 2014 - 12:45 AM


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Special to The Leader
The Orange Leader
AUSTIN, Texas —
The national debate over the future of Medicare is playing a role in some Texas congressional races. Outside GOP groups are spending big bucks to accuse Democratic candidates of supporting $716 billion of cuts to Medicare. Democrats say Republicans want to "end Medicare as we know it." Both charges have been labeled as falsehoods or partial truths by independent fact checkers.
Paul Van de Water, senior fellow with the left-leaning Center on Budget and Policy Priorities (CBPP), insists that the Medicare cuts under "ObamaCare" target overpayments to private Medicare Advantage plans and payments to health-care providers.
"None of this involves actually reducing the benefits that Medicare beneficiaries will receive, in terms of doctors' visits and hospital stays and nursing home stays."
Democrats have relied on a study from Van de Water's think tank to portray a proposal by Mitt Romney as costing seniors more than $6,000 a year, but fact checkers say that figure is based on a previous plan by vice presidential candidate Paul Ryan to create a Medicare voucher program. Romney's current plan, they report, says vouchers could be an experimental addition to traditional Medicare.
Conservatives, such as the Wall Street Journal editorial board, say the passage of "ObamaCare" - which has been widely portrayed as a government takeover of health care - opened up a political window for Republicans to campaign on changes to Medicare that not long ago would have scared off moderate voters. Liberals defend the Affordable Care Act and warn of big setbacks if it is repealed.
Mark Steinberg, deputy director of health policy with Families USA, warns that under Romney's plan, seniors would lose new preventive-care and prescription-drug benefits.
"There are some other problems, too, including changes to Medicaid, changes to the life of the trust fund and Medicare premiums going up - all of which matter to people with Medicare today."
With both sides saying they want to save Medicare, it's up to voters to decide whose approach they trust more. There are signs that the public is serious about sifting through the steady stream of misleading soundbites, 30-second ads and debate accusations. A recent survey found that 64 percent of persuadable swing voters say they are making independent efforts to fact-check candidate claims.


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ANDERSON — Kevin Donahugh made the trip from Missouri worthwhile as he passed John Robbins with 24 laps remaining to win the Grant Fritz/Greg Dietzen Memorial race for the Legends division.
Donahugh was the second different winner of the event in six years at Anderson Speedway.
The classic first started in 1996 and has become a stable on the speedway's annual schedule attracting some of the best competitors from around the nation.
Donahugh was able to get inside of Robbins on Lap 51 following a restart when Robbins' car was unable to maintain the preferred low groove.
Robbins was able to keep pressure on Donahugh, closing to his rear bumper with 15 laps remaining. At the finish Donahugh won by less than a car length.
Ross Rollings finish third followed by Eric Black and Cody Anderson.
Robbins took advantage of a mechanical problem for early leader Aaron Holden on Lap 29 to take the lead coming off the fourth corner.
For several laps there were sparks visible under Holden's car and when his car drifted high in the corner that allowed Robbins and Kevin Donahugh to slip pass.
Holden spun in Turn 2 when the car lost a muffler and was unable to continue.
With Robbins in the lead Donahugh and Ross Rollings swapped the second position several times. Rollings moved into the second spot on Lap 43 and closed to the rear bumper of Robbins when the second caution flag waved when Mark Dietzen lost an engine.
Defending champion David Moyes III, who would have been looking for a sixth consecutive win, crashed Friday night at a race at the Nashville (TN) track and didn't make the trip to Anderson.
With the victory, Robbins qualifies for the national championships later this year at Erie Speedway.


text:
Due to the Labor Day holiday, today's episode of All My Children was a rebroadcast of an episode that aired earlier this summer.
Regular programming will resume tomorrow where Friday's show concluded. There will be no "lost" episodes as a result of this pre-emption.
Share this story with friends, family or the world.
Babe ran into Jamie and Amanda and Amanda, in her own special way, made it very clear that she and Jamie were a couple. After a brief civil exchange with Jamie Babe left. Jamie told Amanda know that he knew she purposely rubbed Babe's face in them being together and that if she pulled something like that again, they were finished. Amanda tried to seduce Jamie, but he rejected her.
Tad told Dixie that she had Julia's life in her hands. He explained that Julia is a target and that her old boyfriend Kevin was the one targeting her. She told Tad that Kevin was not part of a big mob family or a group of hit men. Dixie told Tad to back off but he said he couldn't. She told him she couldn't tell him what she doesn't know. Tad asked if she was scared of Kevin and if that were the case he would protect her. He again pleaded for any information about Kevin and Dixie told him that she wouldn't play with Julia's life. Dixie told Tad that either he had to stop torturing her or he had to leave her forever.
Julia asked Sam why he was living in Pine Valley while his mom and sister were in California. He told her that he was a Martin now. She told him that family couldn't be replaced. He told Julia that his mom just quit loving his dad. Julia told Sam a story about his mom and dad before they were married and how much they loved each other. Julia tried to explain the complexities of relationships to Sam and how couples can change. She told him whatever happened with his mom and dad, it didn't mean that they didn't love each other. He said that he had found his real family with the Martins. She told him that the Martin's were his relatives, but his family was in California.
Zach called Ryan and told him to continue to stay dead and that if he hurt Greenlee or Kendall, he would hunt him down and kill him himself. Mimi then caught up with Zach and wanted to have a talk with him, but he said he was too busy. Then Zach saw Babe and wanted information about Di Kirby. Babe told Zach that if he told her what he had on Di, she might be able to help him. Babe took Zach to where Tad and Dixie were and from behind a tree, they saw Di Kirby kissing Tad.
Erin told Ryan she would take Jonathan to the hospital where he could get the help he needs. Ryan told her that he walked away from his old life and that now she and Jonathan were his family. Erin asked Ryan if they could forget past grudges and start again. Ryan reassured her that he wanted nothing more.
Greenlee realized that if Ryan was alive it meant that he was intentionally staying away. Kendall tried to reason with Greenlee by telling her that Lily was not a reliable witness. Kendall told her that Ryan adored her and he would never run off and live another life. Greenlee told Kendall that they could not go on with their plans to have Ryan's baby, but Kendall reassured her that they were making the right decision. Greenlee said that if Ryan let her believe he was dead, she would have no reason to go on. Greenlee gave Kendall three books on pregnancy as well as an exercise plan. She then told Kendall that she could no longer have shellfish, alcohol and had to divorce Zach. Kendall refused. Greenlee asked Kendall for one good reason why she wanted to stay married to Zach. Kendall told her that her marriage gave her security and she was going to stay married. Greenlee then realized that Kendall cared for Zach. Kendall said the only reason she was staying married to Zach was to keep her from falling for someone else and getting into another failed relationship.
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Tad and Aidan were greeted with a new client: Zach. Mr. Cambias was looking for Di Kirby. Tad was thrown, but only for a moment and asked Zach the typical PI questions about Di. Zach played along briefly and then dropped the bomb he knew Di was Dixie � and he needed her help. When Tad didn't offer any, Zach bolted. Alone with Tad, Aidan wondered if Dixie might be involved with the Julia mess. "She's my Dixie,"said Tad. Apparently he didn't need that DNA test, it only look one kiss. Tad admitted to Aidan he was falling for Dixie and was sure she wasn't lying to him.
After spotting Jamie and Amanda dining together, JR went over to offer a few snide remarks and advise his brother to stay far away from Amanda. Later, Jamie and Amanda had a heart-to-heart about Amanda's mom, Janet-from-another-planet. By the end of the episode, the duo decided to see a movie together.
Di confided in Del that she feared she was about to lose everything. Del advised his sister to keep mum. If she gave away the info that could help save Julia, Di would lose her life as Dixie and possibly her life in general. Di decided to take a drive and her car steered her to see Krystal. The former prison pals talked about Tad, and Krystal warned Di not to hurt him. After leaving Krystal, Di went to get some fresh air. Too bad a mystery person grabbed her from behind.
While trying on a dress for the wedding, Dani's zipper got stuck. And who popped in the dressing room to help her with it? That creepy Garret. After zipping her up, Garret promised to keep all of her secrets, to which Dani answered that there was one secret her mom needed to know: Garret had feelings for Dani. He assured her he didn't have "those" kind of feelings. She confessed he make her uncomfortable, and when Mimi walked up, Garret told Dani to tell Mimi just that. Dani told her simply that she liked the dress. She tried to hint that something was off, but Mimi didn't take the bait as they all stood in front of a mirror like a seemingly happy family.
Babe arrived at the Chandler mansion only to find out the social worker wasn't there yet. At first, JR was adamant she not see the baby, but after she set her plan into motion, JR showed he had a little heart and decided he'd stay and supervise the visit. When Babe realized she forgot a toy for the baby, she went to the car to get it, leaving the baby with JR. When she returned, JR was on the phone. Babe asked where the baby was and the two started looking for him. The episode ending with a spine-chilling scream from Babe.
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Babe and JR search madly for their son, though JR is convinced that Little Adam can't have gone far. Del joins them on the patio to see what the commotion is about, and when filled in, joins the search. Babe takes off to check by the pool, and soon JR is treated to an ear piercing scream, followed by a splash that can only mean she dove into the pool to save their son. He pauses briefly, and then quickly follows the path his ex-wife recently took. The next few moments pass in a flash, and then suddenly a soaked Babe carries her equally drenched son back to the patio with JR on her heels. Little A cries for a moment, and then stops. Babe fears for her son's life and attempts to start CPR. JR, frozen in fear, only reacts when Babe screams at him to call 911. As he does, Tad shows up, disbelieving what is right before his eyes. As Babe continues to work on Little A, Tad holds a frantic JR back, assuring him that Babe knows what she's doing. She finally gets him to breathe again, and JR allows her to hold and comfort him as they hear the sirens getting closer. When the paramedics arrive, JR demand that they call ahead to PVH and have specialists waiting at the door when they arrive. The paramedics tell him that Little A will be checked out thoroughly once they get to the hospital, but they know he will be fine because Babe performed CPR by the book. Babe asks if she can go with them in the ambulance, and JR, after taking a moment to realize that he once again owed Babe for his son's life, says that they aren't leaving without him on board as well. They all take off, leaving Tad and Del behind. Del starts to leave, but Tad stops him and demands to know where he can find Dixie. Del tells him that he doesn't know where she went, only that she said she needed air. Tad, furious that he can't get more information on Dixie's whereabouts, tries to call Dixie on her cell phone. They quickly find out that she left her cell phone behind when it starts ringing where it lay on one of the patio couches. Tad then asks if Zach Slater had stopped by to see Dixie, but Del swears that he didn't see him. Tad pleads with Del to think back over the last conversation he had with Dixie, and tell him anything that might help. Finally, Del says that Dixie mentioned the location where she and Tad first saw each other, this time around. Realizing that she was referring to the cliffs, Tad takes off in search of his beloved.
At the hospital, Babe tearfully looks at the empty crib as JR watches her in the background. When the nurse comes into the room, they look at her, hoping the news she bears is good. She tells them that the amount of time that their son stopped breathing wasn't long enough to cause any significant damage. JR is prepared to do whatever it takes to get Little A thoroughly tested, but the nurse assures him that while there are more tests to come, their son had been through enough that day - and that all he needed now was rest, and his parents. She exits the room, leaving them alone again. It only takes JR a moment before he starts in on Babe, asking how she will exact her revenge: by either going to the cops or to the courts and claiming negligence on his part. Babe tries to assure him that she has no such intentions, but JR is hard pressed to believe her. Babe reminds him of the time that she looked away: back in the days when they had Bess (Miranda)...she was at the park and looked away to help a little boy tie his shoes. When she looked back, the baby was gone. But JR was there, like a hero, to save their baby. She then admits that she knew it was a set up, and that he did it to make her look like an unfit parent. JR worries that Babe will stick it to him because of this latest incident, but Babe runs down the list of panicked thoughts that she had while saving their son, none of which had a thing to do with how to get a better custody arrangement or more visitation with Little A. It's a lot for JR to take in - this acting like their feud is less important than their son. He then quietly asks her if she will teach him CPR. She denies his request - but only because she isn't certified. She tells him that she will go to classes with him, if that's what he wants. Just then, the nurse brings their crying son back into the room. JR and Babe immediately shift their attention to him, and the nurse, who tells them that Little A will be a lot better once he gets some rest. She reminds them about visiting hours, Babe thanks her, and the nurse takes her leave. Once she does, JR tells Babe that her visiting hours are over and Babe looks at him incredulously. Then, realizing the kind of man JR still is, she kisses her son and tells him that she will be back as soon as she can. She goes to leave, but JR calls out to her. He changes his mind because the doctors might have some questions that only she can answer. She goes back into the room and makes a beeline for her son, as JR watches the loving exchange from the background.
During a lunch stop at BJ's, Dani fills a disturbed Simone in on her dressing room mishap with Garret. Simone is taken aback at Dani's unsure tone, and reminds her that not long ago, she too was worried about Garret's true motives. Dani admits that she still is, but she can't be sure if Garret is really making inappropriate advances or if she is completely off the mark. They discuss the possibility, with nothing really resolved. Then, Josh stops by their table to see how they are - and receives a cold shoulder from Dani. As they step away to talk, Ethan swoops into the restaurant, flower in hand, lavishing affection on Simone.
By the bar, Dani rips Josh a new one, calling him a coward because he tried to talk his way out of landing in jail. She tells him that she can still have him arrested - all it takes is one phone call. Josh tells her that she can do what she likes - after she tells him what made her think that he was just playing games with her. She admits that she had a talk with Garret and got the scoop on him. Taken aback, Josh does some calling out of his own - how is it that Dani would take the word of someone who doesn't know him over her own feelings, when she knows him quite well? He asks how Garret got to her, and she recoils a little too violently, insisting that Garret did no such thing. Josh then asks if she plans on telling him exactly what is going on, or if she is going to make him guess.
Back at the table, Simone fills Ethan in on what's been happening. Ethan seems skeptical but Simone tells him that Dani has looks working for her and that as a man, Garret is seeing that. Ethan tries to save himself from being lumped into a category with someone they suspect is capable of such deviant actions, but Simone makes a quip about how Ethan should be willing and able to clean up his gender group.
A short time later, Josh and Dani join Ethan and Simone at the table. After joking about Josh joining Ethan's crusade to rid the planet of all bad guys, they talk in earnest about finding out more about Garret. Dani feels like she has really gone too far with it, and that someday they will look back and laugh at how she overreacted. However, everyone else at the table notes that because Garret is aiming to be a part of her family, it's too important not to investigate. Josh then confesses that he has an idea that might help them on their quest. Ethan tells Dani that the final decision is hers, and asks her thoughts. She says that she hopes they are all wrong about Garret, because she can't envision the horror that will ensue if he is not who he says he is.
At the police station, Garret tries to ease Mimi's fears about Dani and the upcoming wedding. They don't stay cozy for long, as Derek soon spots them and curtly asks if Mimi and her team found any more leads to Julia. Returning the tone, Mimi insists that she came to the station so that she could check in with her team on a secure line. She leaves, and Garret tries to approach Derek for a chat by putting a hand on his shoulder. Wanting little if anything to do with his ex-wife's new man, Derek threatens to throw Garret in jail if he doesn't remove his hand. Garret immediately apologizes, and insists that since he will be marrying into the family, he just wanted to get to know Dani's father better. He invites Derek and Livia to the wedding, and says that it would mean a lot to Dani. Derek makes it clear that he isn't interested, and further states that Garret is to never again attempt to tell him how Dani feels or what is good for her. Knowing that he is fighting a losing battle, Garret changes the subject and tries to make a monetary contribution to a "cops with kids" program. Derek assumes that Garret is trying to buy his way into good standing, and notes that he would prefer to simply handcuff him and lock him away. Before the lid can blow completely off of the situation, Mimi returns and gives Derek some papers to look at, which she believes will diffuse his temper. After giving him a moment to look it over, she reveals that she is petitioning the court to modify their custody agreement. By doing so, Dani is free to choose where she wants to live: New York City, or Pine Valley. Derek suspects that this is just another bribe, and asks what they are up to. Frustrated, Mimi tells him that there isn't anything that she wants from him - Garret just convinced her that it was the right thing to do by their daughter. Derek is unconvinced, as he believed this "generous" offer should have been made when Mimi dumped Dani in his lap over a year ago and walked away. Unable to tolerate his rigid demeanor any longer, Mimi repeats her act and walks out of the room. Garret stays behind for a minute, saying that he has a favor to ask. Derek, slightly gloating because he knew it was coming, invites Garret to bring it on. Garret informs him that the favor has already been asked - they really want Derek and Livia at the wedding. Garret says they feel it is important to show Dani that they can merge the two families and make it work. At this point, Mimi returns. She hears Derek insist that he has work to do, but she can see that his tough exterior cracking a bit. She tells him that while the Santos case is important, she thought that they could slip in some personal business between strategies. Finally, Derek relents and says that he'll talk to Livia. Even if she doesn't want to go to the wedding, he will - for Dani's sake. He walks off, and Mimi and Garret quietly rejoice.
Krystal meets up with Adam at the Roadside Bar, and after trading a few low blows, he asks what she has found out about "Dixie" and any siblings she may have. After getting the boys in the bar to quiet down so she doesn't have to get quite so cozy with Adam, Krystal leads him around by the nose for a moment, discussing how Del knows how to protect his sources, and how popular Paul "Seabone" Hunkle was around Pigeon Hollow. Finally fed up with her delays, Adam demands to know if Del has any sisters that they don't know about. Krystal fesses up that she got Del to cop to having 2 sisters: Dixie and Lanie - but that he clammed up after that. Upset that Krystal failed miserably at his simple request, he tells her that they are no longer working together. Incensed that he could treat their tenuous relationship so carelessly, she stands up and announces that not only is she carrying his baby, she is upset that he won't follow through on his promise to marry her. All of Krystal's biker friends immediately come to her rescue and look at Adam threateningly, while he bleats about how cruel she is to tell such lies. Her friends turn a deaf ear, grab Adam and drag him out the door, protesting the entire way. Once he's outside, Krystal places a call to a travel agency, requesting a ticket on a flight that will take her from Pine Valley to Crow Hollow, West Virginia.
Out in the alley, Adam picks himself up and attempts to dust himself off. When he does, he places a call to his flight crew and tells them to get the jet ready for a trip to Crow Hollow.
Zach shows up at a remote cabin with a kidnapped Di in tow. Fearful that she may come to some harm at his hands, she asks as much with regard to his intentions. Zach tells her that while he would prefer not to hurt her, that subject would be discussed after she tells him everything she knows. Di quickly reveals that she thinks Zach is one of the henchmen in Kevin Sturgess' employ, and Zach does nothing to correct that. She pleads with him to let her go, as she had already promised to never reveal what she knew. Unmoved, Zach plants himself in a chair, proclaiming that he was sent to do a job, and that he takes pride in doing it well. His flat delivery rattles her nerves, and she continues to try to talk her way out of being trapped in the cabin - noting that as long as she stays alive, Kevin is in the clear. However, if she dies, the letter with every last detail of the secret she is keeping will be sent and his cover will be blown. Zach asks where the letter is but Di refuses to divulge that information. He then asks what she is doing in Pine Valley, and she retorts that as long as she keeps quiet, her reasons shouldn't matter. Zach then lets his fa�ade slip a little and asks why the sainted Dixie Martin would do time as Di Kirby. Realization dawning, she demands to know who Zach really is. He tells her that Julia Santos is his friend, and returns the demand by sternly requesting that she give up any and all information that could help get Julia out of danger. She swears that she doesn't know anything that could help Julia, but Zach clearly doesn't believe her. She then warns him away from digging for the truth - simply because he doesn't know what he's getting into. Zach tells her that the look he saw in her eyes when she thought he worked for Kevin is the same look that Julia has in her eyes every day. Di tells him that she can't tell what she knows because it would mean a death sentence - for both of them. She suggests that he let her go so that they can both wake up tomorrow morning, and the morning after that. She starts to beg him, and goes on to say that she wants to be able to stand by her son and see her grandson graduate from Harvard. She tries to leave, but Zach prevents her from doing so. He continues to demand that she tell him everything but she keeps hemming and hawing, knowing that if she spills the beans, they are both dead. After she tells him that his treatment of her almost makes confessing worth it, Zach then asks her where she hid the "in case I die" letter - if he has that, he can get all the information that he needs without her saying a word. Before she can crack and tell him where it is, Tad storms into the cabin and physically attacks Zach. He pushes Zach onto the nearby bed and goes directly to Di, checking to see if she's okay. Zach stumbles to a standing position, and closes the door that Tad came in through. He demands once again that Di give him the name of the person that wants Julia dead. Tad swears that Di doesn't know and insists that Slater get out of their way. Slater then informs Tad that she does know the answers he needs, that everything she told Zach before Tad came in was the truth, and everything that she told Tad since returning to Pine Valley was a lie.
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In Tad's attic, Julia started to pack up her belongings while being haunted by voices from her past. Sam arrived and ordered Julia to stay put. Julia told her nephew about what life in the Witness Protection Program is really like. Sam found the report sobering, but insisted to Julia that she not leave anyway. She remarked that he sounded just like his dad.
At the Canadian hospital, Jonathan reunited with Erin and Ryan after undergoing a battery of tests. Jon then heard a ticking bomb inside his head and started to panic; his sibs tried to calm him down, but his visions expanded to include his menacing father, then Kendall and Greenlee. Ryan and Erin summoned the doc, who restrained Jon. The doctor then informed Erin and Ryan that Jon isn't insane.
Simone, Ethan and Josh encouraged Danielle to set a trap for Garret in order to figure out if he is indeed making skeevy moves on her. After she agreed, the group was interrupted by the arrival of a beaming Mimi, with Garret on her arm. The happy couple reported that their nups were imminent, distressing Dani. Once they left, her pals convinced her to go through with her plan nonetheless, so she made plans to meet up with Garret later. When he returned to the office, Garret fell into Dani's trap, as Josh listened in.
Zach divulged to Tad that "Dixie" has written a letter to be read in the event of her untimely death that discloses the name of the man after Julia. Di furiously denied it. When Tad sided with her, Zach proclaimed him a fool, then left. Tad and "Dixie" got back to his place, where he demanded to know where the letter was. He implored her to tell her who's after Julia before it's too late. Sam interrupted their on-the-verge-of-getting-heated argument, then returned to the attic to tell Julia that Tad would be up soon. Back downstairs, Tad made it clear to Di that he wasn't going to drop the matter. Julia sauntered in and told "Dixie" that even if she didn't tell Tad the name of the guy gunning for her, she'd sure as hell tell Julia...
Greenlee and Kendall set out for a girls' night on the town at the roadside bar. Del sidled up his ex-lover, Kendall, and they enjoyed a pleasant reunion, but Greens sent him packing. As payback, Kendall made Greenlee hit the karaoke machine, where she warbled � what else? � "She's Having My Baby." When the gals returned to Greenlee's, they discovered that Zach was there. He accused Kendall of turning Julia into the police again; she denied it. Zach then revealed to the ladies that he'd found proof in Greens's house of their scheme to have Kendall become the surrogate mother to Ryan and Greenlee's baby � and, he added, he intended to stop it from happening.
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The Kelty Red Cloud Junior delivers trusted Kelty trail performance in dimensions designed for younger backpackers. This classic backpack has load-hauling capability, convenient access points and an array of features.
Ideal for long day hikes or lightweight overnights, the Kelty Lakota Junior internal frame backpack delivers adult performance youth-friendly dimensions. The Lakota Junior offers an impressive combination of durability and affordability.
The rugged Mountainsmith Youth Pursuit internal frame backpack offers 3051 cubic inches of storage space. Load-carrying capability and organizational features combine to make the Youth Pursuit an ideal option for young adventurers.
The versatile panel-loading Mountainsmith Approach 40 backpack has the organizational and performance features you need for weekends in the backcountry, technical day hiking and extended travel. Fits torsos ranging from 15"-19".
Designed to tote a single day's worth of gear, clothes or books, daypacks are perfect for the trail, around town or the classroom.
These packs are sized for overnights or a weekend with smaller lightweight gear.
Ideally sized to carry an average tent, sleeping bag and a typical weekend's worth of food and gear.
Larger packs for trips of 3 or more days or weekends with lots of gear.
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Hear the untold stories of enslaved people and learn about historical and contemporary slavery.
A beautiful building housing one of the UK's finest collections of fine and decorative art.
Uncover objects from the Titanic, find out about life at sea and learn about the port of Liverpool.
This new museum tells the story of Liverpool with diverse exhibits housed in a stunning building.
Explore a Victorian merchant's house with its period furniture and beautiful paintings.
Beautiful paintings, sculpture and decorative art from the 13th century to the present day.
Discover treasures from around the world, explore outer space and meet live creatures!
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I am holding a second Beginner's Race Clinic on February 21st.
http://www.wenzelcoaching.com/Camps&Clinics.htm [1]
The clinic is designed to be complementary to the Early Bird Training Sessions and reach those riders who either missed or heard about the Early Birds too late.
All new racers, attending the clinic or not, are encouraged to participate in the Early Birds as much as possible. Skills learned at the clinic are intended to enhance and build on what is taught at the EBs.
See you at the EBs.
Ron Castia


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Soon, the Catholic Church will need to pick a new pope now that Pope Benedict XVI is resigning his post at the end of the month, so what are the odds that an American could replace him?
It's not a job anyone can apply for -- and it's not typically one that gets quit, but at 85 years old, Benedict said he is simply too weak to continue in the role.
In addition to leading the prayers and policy for one billion Cathoilcs across the globe, the pontiff also serves in the role of religious diplomat and has a strong influence on international relations.
Professor Massimo Faggioli is a nationally-known historian of Catholicism, and he says the announcement could be a game-changer for the church.
"We've never had this kind of situation, when the next conclave -- in a few weeks -- will elect a new pope knowing that the former pope is still alive," he explained.
Even so, Faggioli thinks it's unlikely an American cardinal would be elevated to the church's highest post since the U.S. is already widely seen as an economic and military superpower.
"In political terms, we could say that the Roman Catholic Church is the last empire. It's everywhere. It's in five continents," he said.
Benedict plans to resign at the end of February, but many Minnesota Catholics told FOX 9 News they prefer to think of it as retirement.
A Vatican spokesperson said it is likely that a new pope will be appointed by Easter.
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Scott charges to be tried separately
Bank robbery suspect Michael Scott will face separate trials on two charges that were until now combined for one trial. In a motions hearing Wednesday, Public Defender Bernie Straetker argued that the bank robbery charge and the theft and fraud charges involving ATM cards should be tried separately.
County Attorney Doug Warner told the court that after reviewing the statutes, it appears the two cases should be handled separately. With no objection from the prosecution, District Judge Randy Lippstreu granted the motion to sever the cases.
Since pretrial was already scheduled for April 25th, the Judge requested the prosecution decide which case would move forward in the May jury term and inform the court by April 23rd ahead of the scheduled pretrial hearing.
The 42 year old is accused of robbing the Valley Bank and Trust branch at Broadway and Beltline in Scottsbluff just before Thanksgiving of last year. He is also accused of theft and fraud involving bank ATM cards. Scott will face a third trial involving the alleged assault of an inmate while being held in the Scotts Bluff County jail.
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Flying to see us soon? You'll be happy to know you have yet another way to get to Hilton Head Island quickly and inexpensively. JetBlue recently announced it will add service to the Savannah/Hilton Head International (SAV) airport, its 50th destination, with flights from New York's JFK and Boston's Logan airports. The Savannah/Hilton Head International airport is just a few exits down I-95 from the Hilton Head Island exit, making it a convenient and easy way to get to the island.
Beginning Feb. 13, 2014, there will be two daily round-trip flights to JFK and one daily round-trip from Boston. From these airports, you can connect to other destinations, such as Denver, Los Angeles, Albuquerque and San Francisco.
They're currently offering special $89 one-way fares for travel between Feb. 13-April 10, 2014, so we highly recommend booking your Hilton Head spring break airfare now! To book flights and check rates, visit www.jetblue.com.
Regarding the Boston flights, JetBlue'Äôs vice president of network planning Scott Laurence says, "Bostonians work hard, and they need more great places to get away. Savannah/Hilton Head¬Ýis an easy weekend getaway or vacation, and priced right so our customers can get away more often." We couldn'Äôt agree more! Now, you'Äôve got one more reason to come and enjoy all that Hilton Head Island and Palmetto Dunes has to offer from tennis and golf to biking and the beautiful Atlantic Ocean.
JetBlue carries 29 million customers a year to 79 cities in the U.S.,¬ÝCaribbean¬Ýand¬ÝLatin America with more than 700 daily flights. On JetBlue, all seats are assigned, all fares are one-way, and an overnight stay is not required. Your first checked bag is also free on JetBlue, and they offer a range of amenities like free DirectTV, free SiriusXM Radio and satellite WIFI.
Would you consider JetBlue for your next flight into Hilton Head?
Be sure to check out our Fall Escape Special with three FREE nights when you book four nights, plus free daily tennis and discounts on golf, bike rentals and more. Good for bookings through Oct. 31, 2013.


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The Duke University Board of Trustees has voted to rename Aycock, a freshman dormitory named for Gov. Charles B. Aycock, according to The Duke Chronicle, pointing to Aycock's racist views as a reason for the change.
The dorm will be named East Residence Hall, which was its original name.
Aycock was elected governor in 1900 and embarked on an ambitious program to ramp up public education in North Carolina, which had languished after the Civil War. But he endorsed segregation and did not believe blacks should vote.
Aycock was one of North Carolina's leaders at a time when whites re-asserted dominance after the end of Reconstruction, and he traveled the state speaking about the importance of white supremacy.
Once he became governor, education was his priority. But how public education would be funded was a critical issue in Aycock's time – many powerful white leaders did not want taxes to fund education for blacks. Aycock's compromise was that taxes from whites would fund white schools, and taxes from blacks would fund black schools. The disparity in wealth, however, led to substantially different funding for schools between the races.
When Aycock was elected governor, North Carolina had 900 public school districts with no school houses. During Aycock's four years as governor, the state added 1,100 schools.
Aycock served as governor for four years. He decided to run for the U.S. Senate in 1911 but died while giving a speech on the importance of education in Birmingham, Ala. He is buried at Oakwood Cemetery in Raleigh.
Aycock High School in Pikeville is named for him and his birthplace in Wayne County, near Fremont, is a North Carolina historic site.
Aycock graduated from the University of North Carolina at Chapel Hill in 1900. A residence hall at UNC is also named for him.
A statue of Aycock pointing to a book is one of North Carolina's two statues in the U.S. Capitol.
A book entitled "The Life and Speeches of Charles Brantley Aycock" from 1912 said of Aycock records his career. In the introduction, the authors say,
"IN LOOKING over the completed chapters of this volume, that which seems to stand out clearest, even where our first aim has been to record achievements and labors, is the personal character of Governor Aycock. It is well if this is true. It is, in our opinion, not his greatest distinction that he was at one time Governor of North Carolina and one of the greatest of our Governors, nor yet that he was a leader in a great revolution that established the political supremacy of the white race in North Carolina, and in another revolution that made universal education forever 'a matter of course instead of a matter of debate' in the Commonwealth. His greatest distinction is rather that he was the most beloved North Carolinian of his generation."
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Sami and her long-time friend Michiko Watanabe, 78, in Sami's living room in her pre-fab housing. The forced evacuation has been hard on them, but they take care of each other.
© Noriko Hayashi / Greenpeace
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Longboat Key temperatures reach record highs
August 25, 2014
Temperatures reached a scorching 100 degrees over the weekend.
Primary election takes place tomorrow
August 25, 2014
Longboat Key residents vote at two separate places on the island, depending on whether they live in Sarasota or Manatee county.
PHOTO GALLERY: Sarasota Bay Watch Scallop Search
August 23, 2014
More than 130 volunteers searched for scallops with Sarasota Bay Watch Saturday, Aug. 23.
Longboat Key makes list of Florida's safest places
August 22, 2014
The town is the 10th safest city in Florida, according to Safe Choice Security's "20 Safest Cities in Florida."
PHOTO GALLERY: St. Mary Men's Club Hot Dog Cookout
August 22, 2014
Guests gathered for St. Mary Men's Club's first annual Hot Dog Cookout Thursday, Aug. 21, at St. Mary Star of the Sea.
PHOTO GALLERY: Business After Hours
August 21, 2014
Liquid Limousine Charters and Kathleen D Sailing Catamarans sponsored the Longboat Key Chamber's Business After Hours event Thursday, Aug. 21, at Harbour Square.
Mote and Florida Fish & Wildlife release snook into Sarasota Bay
August 21, 2014
More than 2,000 snook were released over three days.
Think Tank
August 21, 2014
Mote Marine Laboratory and Aquarium is intent on expanding its research capability on its City Island campus — and hopes to build a new bayfront aquarium on the mainland.
The Faces of Summer
August 20, 2014
We took to the streets to take a closer look at the people and places of Longboat Key during the off-season. What we found was that the Key is still in season for a variety of people who live, work, visit and shop in the area during the summer. Although the weather is hot and humid, the visitors and residents we found out and about over the weekend are the pulse that brings the town to life.
County to hire consultant to review Big Pass dredge
August 20, 2014
After Sarasota County Commissioner Nora Patterson raised some stipulations, the board unanimously agreed to find a third party to review the Lido Beach renourishment project.
- Oct
2 Florida's Children First 2014 Sarasota Reception
5:30 pm - 7:30 pm
- Oct
16 Pillar of Hope Open House
5:00 pm - 9:00 pm
- Oct
17 Taste of St. Armands
5:30 pm - 8:30 pm
- Oct
17 Night of Fish, Fun & Fright
6:30 pm - 9:00 pm
Goliath grouper lives up to name
Talk about a real big fish.
Mazel tov to Klauber and Mancini
The West Coast Florida Region of AJC (American Jewish Committee) will honor Michael Klauber and Phil Mancini, of Michael's On East, with its Civic Achievement Award in November.
Bob Havel celebrates 90 years with family members
Bob Havel recently celebrated his 90th birthday on Longboat Key with 24 members of his family.


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Funding opportunities
CPMC Shared Research Laboratory
Funding Type:
Shared Labs
Grant Number:
Funds requested:
$809 063
Funding Recommendations:
Not recommended
Grant approved:
Public Abstract:
Human Embryonic Stem (hES) cells have the capacity to become all of the cell types of the human body. However, clinical applications of these cells require an understanding of how to isolate the downstream embryonic progenitors (EPs) of specific tissues. The CPMCRI Shared Research Laboratory (SRL) proposes to utilize a new two-step single cell technique to rapidly isolate a large number of potentially useful EPs, expand the number of those cells, test them for quality, and then share those purified cell types with other medical researchers throughout California. Specifically, the SRL will: 1. Isolate uniform populations of novel EPs that can become different tissues directly from discarded human IVF embryos. Using the two-step technology, ~ 1000 novel cell lines will be isolated and analyzed for gene expression and quality, banking, and distribution. 2. Isolate uniform populations of novel EPs that can become different tissues from hES cells derived from discarded IVF embryos carrying disease genes. In collaboration with Pacific Fertility Center, embryos carrying disease genes will be used to generate hES cells or caused to change into cells that can become different tissues using the two-step technology. Novel disease-bearing EP lines will be provided to California researchers in parallel to the normal lines for drug discovery and inherited disease research. To this end a 1500 sq/ft laboratory at CPMCRI will be renovated and dedicated as the SRL for stem cell research not sanctioned by the Federal Government. The facility will contain 3 cell culture hoods, 6 incubators, a cryopreservation system, microscopes, centrifuges, a robotics cell culture platform, and various equipment items necessary for cell culture. The Principal Investigator will serve as the Director of the facility. A Facilities Manager will be responsible for the day-to-day supervision of the facility. Core personnel will be responsible for the culture, cryopreservation, and distribution of the cells to researchers at CPMCRI, neighboring institutions, and institutions throughout California. CPMCRI researchers have projects that include neurological disease (ALS and nerve cell regeneration), cancer (breast cancer stem cells and cell migration), cardiovascular disease (myocyte regeneration), and inherited disease-related organ repair (cystic fibrosis and sickle cell disease).
Statement of Benefit to California:
The proposed research at the CPMCRI SRL benefits the people of California by providing medical researchers in the state novel human cell lines useful in both basic scientific study and potentially for use in the treatment of numerous degenerative diseases. The CPMCRI SRL will provide its collaborators with human embryo-derived cells that are more differentiated than human embryonic stem cells, are closer in their characteristics to the actual tissue that they are intended to repair, and therefore are closer to therapeutic application. The role of the SRL at CPMCRI will be to generate, characterize, test, and distribute these cell lines derived from normal human embryos through a process of direct differentiation wherein human embryonic stem cell lines are not utilized. In addition, the CPMCRI SRL will generate EPs from embryos carrying inherited disease gene alleles. The novel method of deriving these cells and the unique genetic properties of those generated with abnormal genetic backgrounds, offer a unique service to California researchers, useful in understanding the biology of disease and early human development, cell based drug discovery, and for the cell-based treatment of degenerative disease.
Review Summary:
SHARED LABORATORY SYNOPSIS OF PROPOSAL: The stated goal of this application addresses establishing a Shared Research Lab (SRL) focused on an important area of stem cell research - the isolation and expansion of novel, clonal, stable, partially differentiated embryonic progenitor (EP) cells isolated from two sources: 1) direct differentiation of discarded IVF embryos; 2) the direct differentiation from embryos or human embryonic stem cell lines from discarded embryos diagnosed with genetic diseases. This work will be performed in collaboration with the Pacific Fertility Center. All of these embryonic progenitor lines would be made available to investigators to allow them to have access to uniformly committed lines of cells for terminal differentiation, thus avoiding some of the early pitfalls. To carry out this goal, the applicant proposes the renovation and equipping of 1500 square feet of laboratory space for an SRL for stem cell research not sanctioned by the Federal Government. A lab manager and core personnel will isolate EP lines using "two step clonal isolation technology", culture, cryopreserve, test and distribute lines internally and externally to institutions throughout California. The institution's investigators conduct research in neurological disease, cancer, cardiovascular disease and inherited disease organ repair. QUALITY AND IMPACT OF THE SCIENCE: The SRL would provide a source of new human embryonic progenitor (EP) cell lines with varied and early differentiation properties, but with still robust proliferation capacity. A list of PIs that would presumably be users of the lab is given, but no documentation of the nature, extent or purpose of their use is provided. Indeed, the implication is that the SRL would be dedicated to the generation of lines by the lab manager, a technician and the director. This grant proposes the establishment of an SRL for the generation of human embryo-derived cells. As such, these goals fall outside of NIH guidelines, yet do not involve the derivation of hESCs. No research is proposed. The proposed SRL will be used to isolate hundreds of diverse and scalable EPs from two novel sources – direct differentiation from discarded embryos from IVF and from embryos or cell lines derived from discarded embryos carrying disease alleles using a "two-step clonal isolation technology". Approximately 1000 novel endodermal, mesodermal and ectodermal embryonic progenitor clones will be isolated, tested for quality, expanded, banked, and shared with qualified California researchers. A large bank of clonal hEP cell lines with a wide variety of primitive differentiation properties would, in principle, be a valuable resource for stem cell biologists to screen for a renewable cell source for a wide variety of therapeutic, toxicologic, and pharmacologic applications. More critical evaluation of cell lines and the nature of those analyses should be an important consideration prior to their release to other researchers. No research on adult or nonhuman stem cells will be performed. The qualifications and productivity of users of this cell-resource will be determined by who requests cells. Fifteen investigators are listed in the application: 10 are from the applicant institution, 1 is from Blood Systems Research Institute, 1 is from Advanced Cell Technology, 1 is from UC Berkeley and Advanced Cell Technology, 1 is from UCSF and 1 is from USF. The description of preliminary cell culture studies does not clearly delineate the experience of the PD, Dr. Gruenert, nor the experience of Dr. Chu, based on the cited references. In fact, Dr. Gruenert has extensive experience with cell culture derivation of human airway epithelial cells and Dr. Chu has derived hESC progenitor cell lines at Advanced Cell Technology. It was unclear to the reviewers what the research plans were for use of the proposed space by most of the investigators. Although the application contains bio-information about many highly qualified individuals and letters of support; it lacks sufficient information to understand what work will actually be performed by these investigators as a result of establishing the SRL. There were four figures included without discussion that appear to illustrate current research, but the PI associated with the figures is not stated. Although eight other PIs from CPMCRI are listed (besides Dr. Guernert and Dr. Chu), there are no roles or projects described for them, no indication that they will use the space or equipment, and none have prior experience with stem cells. This lack of relevant information severely limits enthusiasm for this application. The goal to create a resource of quality controlled early embryonic progenitors is valuable and important, but the relationship of this goal to the listed investigators is not provided, nor are the areas of research and plans/goals for the SRL clearly stated. APPROPRIATENESS OF SPACE AND EQUIPMENT TO SCOPE OF PLAN: Fifteen hundred square feet of laboratory space is to be renovated and dedicated as a non-federal shared research laboratory. The laboratory would be equipped with 3 cell culture hoods, 6 incubators, a cryopreservation system, microscopes, centrifuges, robotics cell culture platform, and "various items of cell culture equipment." The size and scale of the lab, equipment and personnel are appropriate for its single dedicated purpose of providing a large, unique source of human EP cell lines. A biosafety hood is available for other users, if needed. The project is not designed to meet the needs for NIH-free research space, training, or direct collaboration with other investigators of the host or neighboring institutions. It seems that this space and equipment is largely to be used as a facility for the aforementioned EP generation, and then as a shared research laboratory only as an afterthought. While these attempts at EP generation may be laudable, this is not the appropriate forum for funding of this grant application. Documentation of the need and projected use by other investigators would greatly increase the enthusiasm for this SRL application. Much NIH-free space is available at CPMCRI, and the intent of this application is not to provide access for researchers to equipment and space for work with cells not in the NIH-registry. Rather, the purpose is to equip space already available to apply a specific technology to create a thousand new stem cell lines. QUALITY OF MANAGEMENT PLAN: The quality of the plan to support, manage and maintain the lab and equipment is adequate, because a single dedicated project for one investigator and the absence of other committed users from within or without the host institution means little management is necessary. The ambiguity regarding other users needs clarification. The program director has long-term expertise in developing human non-stem cell lines, including hematopoietic multipotent progenitor cells, but has no publications demonstrating expertise with hESCs or generating stem cell lines. The qualifications of Dr. Chu to operate the ACTCellerate are likely unsurpassed, because she has been hired from ACT where her duties involved generating these kinds of embryonic progenitor lines, presumably using the ACTCellerate system, but that was not explicitly stated. In addition, preliminary studies with data presented suggest that useful partly differentiated cell clones can be obtained. However, it is not clear whether the data is derived from work with an ACTCellerate at CPMCRI, at ACT, or is information provided by ACT. Dr. Gruenert lists only 15% effort on this project, and Dr. Chu and the "to be named" technician will each devote 75% effort to this project. It is questionable whether this is sufficient personnel to derive, expand, characterize and bank the stated 1000 embryonic progenitor cell lines in three years. Although there are no descriptions for work in the SRL by any other than the technician who oversees the ACTCellerate and robotics instrumentation, scheduling is proposed to be on a signup first-come, first-serve basis with a web-based calendar. There is a clear institutional commitment to provide space for the Shared Lab. The oversight committee is advisory with emphasis on the technology and technology transfer. It is composed of comprised of highly knowledgeable, capable individuals from the Pacific Fertility Center, Advanced Cell Technology, the CPMCRI Tech Transfer Office, the director and assoc. director of CPMCRI, and the program director, who is also the chair of the CMPCRI SCRO. DISCUSSION: All the reviewers agreed that the proposed work – to derive 1000 lines from discarded and PGD embryos and then partially differentiate them, store and make available for research use - is conceptually good. However, significant parts of the proposal were missing such as the research of other proposed users and how this facility would enable such research.


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CATEGORIES Sci-Fi & Fantasy, Warner Brothers, Scripts, Remakes and Sequels, Western, CinematicalWouldn't you love to go to a theme park that supplied robots to fulfill all of your fantasies or at least watch people go and fulfill their own? Michael Crichton wrote about that very experience in 1973 and now Billy Ray is writing his take on what an android fantasy amusement park would be like in the remake of Westworld for Warner Brothers. In the original film the theme park supplies three worlds in which humans can play in; a Western themepark, harboring the android of Yul Brynner (the dreamiest bald guy I've laid eyes on), a Medieval world and Roman world. Humans paid a hefty $1,000 admission ticket to be satisfied in any way they desired and the robots were programmed to comply. Unexpectedly, the android Brynner begins to rebel against the programming and begins to attack and kill the humans. Eventually, someone puts an end to the android violence (after three attempts, mind you) by sending the gun-slinging Yul Brynner to his death.
Ray, who most recently came out with the February release Breach, with Laura Linney and Chris Cooper, reported to SCI FI Wire that "I love the basic idea of the movie, which is that our amusements can kill us." He didn't give any thoughts as to eventual casting, however. Who would you cast as the gun-slinging android? I vote Bruce Willis circa the current issue of Vanity Fair or Billy Zane ... he was just so spectacular in Titanic.


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Red hot snapper fishing after Hurricane Ikeby Willie Howard
Snapper fishing was hot, hot, hot last week after Hurricane Ike blew by under South Florida.
"They're nice, big, beautiful yellowtails," drift boat captain Ira Laks said Sunday after his clients caught 11 muttons and 30 'tails on a half-day trip in 70 to 120 feet off Singer Island.
On Saturday night, captain Bill Taylor of the Black Dog took out a bachelor party that hit the snapper jackpot. They caught about 100 fish drifting in 90 feet between the Juno Beach Pier and Jupiter Inlet.
"This is as good as it gets," Taylor said. "We did one three-hour drift and never stopped catching snapper."
Action was even better just as the seas were settling last Friday from the effects of Ike.
Scott Sanders headed offshore on the Tramp II to drift for snapper that Friday and caught a 9-pound mutton snapper. His fishing buddy, Linda Adkins, caught a 29-inch "flag" yellowtail that weighed 7 pounds.
Sanders said Adkins caught the jumbo yellowtail using a dead sardine on a circle hook in 60 feet near the south end of John D. MacArthur Beach State Park.
Kingfish were all over the place that day, too. They went out again Saturday and had another fantastic day of snapper fishing, Sanders said.
Tags: Bill Taylor, Hurricane Ike, Ira Laks, mutton, snapper, yellowtail


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About the Author
Mike Wilkening
Senior editor
Recent posts by Mike Wilkening
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Here's a matchup to watch in Sunday's Dolphins-Browns game:
Browns RS Joshua Cribbs vs. Dolphins PK Dan Carpenter, P Brandon Fields and Miami's return units
Cribbs earned AFC Special Teams Player of the Week honors after he was one of the catalysts for Cleveland's 27-19 win at Indianapolis last Sunday. His two longest returns — a 52-yard kickoff return in the second quarter and a 43-yard punt return in the fourth quarter — set up Browns' touchdowns.
The previous week, Cribbs was nearly as productive. With the Browns trailing 13-0 in the second quarter, Cribbs' 51-yard kickoff return helped spark a Cleveland comeback. The Browns followed that with their first touchdown of the game and eventually took a 17-13 lead. With Cleveland later trailing 20-17 late in the fourth quarter, Cribbs broke a promising 21-yard punt return that could have been a much longer gain if not for WR Greg Little accidentally crashing into Cribbs after delivering a booming block on Bengals P Kevin Huber.
Cribbs didn't get an abundance of optimal return opportunities a season ago, and he suffered a concussion and injured toes. This season, he's back in top form. He made Indianapolis pay dearly for kicking to him, and he nearly did the same vs. Cincinnati. He's yet to return a kickoff or punt for a touchdown this season, but he's knocking on the door.
Whether the Dolphins can limit Cribbs' return chances could be one of the keys to the game, considering how well he's played. PK Dan Carpenter's longest kickoff this season was a 74-yarder vs. Houston, which was returned for 34 yards. A 71-yarder was returned 43 yards by Houston's Danieal Manning, a good returner in his own right. In the season opener vs. New England, Carpenter's longest kickoff traveled 71 yards, with the longest Patriots return 37 yards.
Dolphins P Brandon Fields has a strong leg; six of his nine punts have been 50 yards or longer, including a 70-yarder vs. Houston. But about that 70-yarder: the Texans' Jacoby Jones caught it with the nearest Dolphin almost 30 yards away. By the time Jones was able to gather himself and start moving forward, the Dolphins' coverage unit had started to close in, but Jones was able to get past the first wave of defenders, and he wasn't stopped until he had notched a 40-yard return.
For the record, Fields' other punts vs. Houston were very good — a 50-yarder produced no return, and a 61-yarder netted 65 yards after a four-yard loss on the return. However, if the Dolphins are pinned deep and Fields (who's had 8-of-10 punts returned) has to let it fly, the Browns will likely get a chance to set up a return. Then it will be on Miami's coverage units to bring down one of the game's return aces.


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By Gail McCarthy
Staff Writer
---- — The towering wind turbines rising above Blackburn Industrial Park have already translated into revenue with the city, clearing $60,000 in the first three months, according to Mayor Carolyn Kirk.
That was just one element of information shared Thursday night by Kirk and three experts at a wind energy panel discussion that prompted more than 300 Gloucester and Rockport residents to flock to the Sawyer Free Library for a panel discussion on wind energy.
Within three months worth of performance, Kirk said this year's revenue projection for this calendar year will be $430,000. The only reason that is below the $450,000 estimate is that in the first few months of operation, there were glitches that needed to be addressed and required the turbines to be turned off. Once the operation is in full swing, Kirk said the city will be on track to meet its savings projections.
The city benefits because it partnered with Equity Industrial Turbines LLC, which erected the two turbines at Gloucester Engineering at Blackburn Industrial Park. The turbines were erected in November and put into operation on Dec. 31.
"They did all the work, took all the risk, and financed the two turbines for $10 million, and we collect the check," said Kirk. "The more they spin, the more we get."
Varian Semiconductors/Applied Materials, the city's largest employer, paved the way in the permitting process by being the first to start the process of installing a wind turbine in Gloucester. Varian has the largest of the three. The motivation for both projects was their large consumption of electricity and a move to enter the realm of clean energy.
The Varian turbine is 328-feet tall and the diameter of the rotor is 328 feet. The other two turbines stand at 256 feet tall and their rotor diameter is 295 feet. The Gloucester Wind turbines weigh in at 683,433 pounds.
"The turbines seem to be the biggest buzz around town," said Gloucester Ward 1 City Councilor Paul McGeary, the panel moderator. "We wanted to present everything you wanted to know about Gloucester's new skyline. The turbines on the hill send a message to world about Gloucester. Those turbines signal that Gloucester is open for business."
Note cards were circulated among the audience to submit questions for the panel. While most in the audience supported the wind energy projects, a few cards from disgruntled residents were also read aloud.
"I didn't expect something like jets taking off," wrote one resident.
But the major thrust of the Gloucester Lyceum event was positive, with residents eager to know the details of the project. In addition to Kirk, the panel was comprised of Rick Johnson, the facilities manager at Varian/Applied Materials and the Varian turbine project manager, Tom Michelman of Boreal Renewable Energy Development in Arlington, who presented turbine study highlights, and Sumul Shah, the CEO of Sloaya Energy, who discussed turbine construction and operation.
"It started with a cold call out of the blue from Bob Shatten from Boreal in 2003," Johnson related. "He said 'we think we can save you some money with wind turbines.' They saw our electricity profile and ... we're on one of the strongest wind production sites in Massachusetts."
"Why our project? Because we spend a ton of money on electricity," he said. Varian spends $3.1 million annually on electricity, and the savings from the turbine will be $1 million a year, said Johnson.
Varian went through two years of the permitting process, and would pave the way for the second wind energy project. The permitting process involved local, state and federal agencies, including the planning board, conservation commission, the FAA, the Federal Energy Regulatory Commission, U.S. Fish and Wildlife Service to name a few. The financial meltdown at the end of 2008 had an impact, but they forged ahead.
Johnson noted that the turbines mean a reduction in carbon dioxide, nitrous oxide, sulfur dioxide and particulates.
"We are helping the environment by avoiding fossil fuel generators," he said.
Johnson also mentioned that the Varian turbine is monitored around the clock in Germany.
Michelman, representing Boreal, shared several highlights — and fielded a question about the impact on birds.
"On an annual basis, turbines get one or two birds a year," he said. "Cats kill more birds."
On the technical side, he highlighted the ideal conditions here that support the creation of these projects. One is that the industrial park already has a robust electrical infrastructure. He noted the need for height with wind turbines because the more turbulent wind is closer to the ground so the higher the better. Gloucester, located on an island, had ideal wind speed with its proximity to the ocean.
"Gloucester is special," said Michelman.
Shah, of Solaya Energy, talked about the need for the large size.
"The larger the rotor, the more surface area to capture the wind," he said. "Why so tall? Because wind speeds are greater at higher elevations," he said. The height also helps to avoid the turbulence closer to ground.
He explained that the modern turbines don't work like the windmills of centuries ago, when air pushes the blades that causes them to spin.
"While they may look similar, the way they capture the wind works in a different fashion. It works very much like an airplane wing. The blades are a special shape and designed to maximize the wind. Air flows faster over the top and causes it to lift. Air causes the blades to rise and that causes turbines to spin," he said. "The blades pitch so you can adjust the speed of the blades. On a plane, you can see flaps changing to change speed, and the same applies to wind turbines."
He went on to explain that the slow-moving blades turn gears that cause a generator to spin really fast, and the spinning generator produces electricity.
"They look like they are spinning slowly – about 20 rpm, a gentle rotation, but inside is the gearbox that converts that to 2,000 rpm," he said.
A transformer is used to apply that energy to the local grid, but there are no large batteries to store the power because that energy goes into immediate use or goes into the local grid.
"The nice thing about this site is that it is so close to where (the energy) needs to go to," said Shah.
Kirk noted that the projects here have come amid a movement to "go green," and referred to the city's Clean Energy Commission.
"The benefits would have been greater if we had city-owned projects," the mayor said, "but I believe the municipality is not the right owner/operator of such cutting-edge technology.
"Based on some good advice, I felt that we needed some private industry to finance and partner with in some way so the risk is all taken by private industry," she added. "In this way, the citizens of Gloucester don't have to worry about whether public works is taking care of the turbines. They are being taken care of by experts."
Gail McCarthy can be reached at 978-283-7000, x3445, or at firstname.lastname@example.com.


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As we all know, West Ham has been relegated. This means there is not a chance in hell Scott Parker is going to join them in the Championship next season. He's tough and multi-talented, the kind of midfielder we haven't really had since Vieira (not that i'm saying he is a Vieria). He could cover multiple roles in our midfield (most importantly, as another enforcer since we are thin there) and would be a serious upgrade over the likes of Denilson.
I predict (not that it is hard) that multiple premiership teams are going to be fighting for his services. So the question I put forth to you is, should we be in that conversation? Keep in mind the possibility that Cesc may not stay.


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Seven soldiers with the 96th
Civil Affairs Battalion received medals for valor during a ceremony this morning
at Fort Bragg.
Staff Sgt. Michael P. Pate, of
Charleston, S.C., was presented the Silver Star medal for actions during a
reconnaissance patrol in Afghanistan.
The Silver Star is the third
highest military decoration for valor in the United States Armed Forces.
During the ceremony, held at the JFK Memorial Auditorium, Lt. Gen. Charles T. Cleveland, commanding general for the U.S. Army Special Operations Command, also awarded two Bronze Star Medals with Valor Devices, and four Army Commendation Medals with Valor Devices.


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Christine May ReviewsChristine May
Broker, ABR , Real Estate Broker, GA & SC (19 years experience)
83 Recent Sales (last 12 months)
Buyer's Agent, Listing Agent, Relocation, Foreclosure
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12/20/2013 - mariapullen
Bought a Single Family home in 2006 for approximately $225K in Martinez, GA.
Ms. Christine May was very instrumental in making my family's move from Fort Drum, New York to Augusta, Georgia a pleasant one. Being a military family and having to deal with constantly moving can be stressful and overwhelming but Ms. Christine May was very understanding and patient with us and met all of our needs, demands, and more. She was very dependable and consistently impressed us with her willingness to do whatever it took to get the job done. My family and I were able to make a smooth transition from one duty station to another thanks to Ms. Christine May's professionalism and knowledge of her job. I always recommend her to family, friends, and coworkers.
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09/06/2013 - mixpix45
Bought a Single Family home in 2012 for approximately $150K in Martinez, GA.
We bought our house using Christine and Drew, and in the future I will definitely not be utilizing them to help me sell. They are only about their own bottom line. Once we settled on a house and signed all our closing paperwork, we never heard from Christine or Drew again - I only got to speak with their assistant. When we closed on our house, the old property owner was at the house and he had left copious amounts of garbage throughout the property. Unfortunately I had not noticed because he walked through the entire house with me and I did not even imagine that somebody would leave their bathroom drawers full of garbage. Our backyard was full of garbage. Once again, Christine or Drew were nowhere to be seen for the closing.
This real estate company in particular was nothing but unpleasant to work with. Oh, and of course the closing was postponed too because nobody liked to communicate in a timely manner with me or the sellers realtor. Ridiculous.
This real estate company in particular was nothing but unpleasant to work with. Oh, and of course the closing was postponed too because nobody liked to communicate in a timely manner with me or the sellers realtor. Ridiculous.
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03/31/2014 - htrn1978
Bought a Single Family home in 2014 for approximately $300K in Appling, GA.
I worked with Christine after cold calling several realtors in the area. I was moving in from out of state and found her and her staff to be extremely responsive and helpful from the start which is why I decided to use them as my agent. All through the process, Christine, Drew and Crystal took care of even the smallest detail without any inconvenience to me and my family. I had to fly down for several quick turnaround trips to view as many homes as possible within a short time frame and they were always ready and made every house we wanted to look at fit within our schedule. Their knowledge of the area certainly helped us find the house that we were looking for within the price range we could handle. Their network of contacts with the various entities needed for closing made the process seamless. I would definitely work with Christine and Drew again in the future.
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03/28/2014 - user4241252
Bought a home in 2014.
We were looking for a foreclosure that needed some repairs. We gave Christine our budget and location we would have liked to settle in. She took that information to task and let us view the house we eventually bought before it came on the market. Christine has a pipeline of other realtors that feed her inventory and she was able to match us up perfectly! It was a pleasure working with Christine, Crystal, Drew and Samantha. I would highly recommend them as your future realtor.
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03/27/2014 - kj smith2008
Bought a Single Family home in 2014 for approximately $125K in West Side, Augusta, GA.
This bunch is great! They showed us many of properties that was in our price range and even filled us up with the best coffee! Christine connected us with a great mortgage plan! Their assistant Crystal Morgan is the best! She made sure everything ran smooth and the contractors did what they promised! She don't take crisp and deals great with inspectors and contractors! These folks are who you want on your team! We were first time home buyers and they tauht us much about the real estate business! They handled everything on a prompt manner and kept us informed about everything that was taking place! We had a great experience with them and wouldn't have it any other way!
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03/26/2014 - philip rausch
Bought a Single Family home in 2013 for approximately $125K in Waynesboro, GA.
Christine was a God send. I had contacted another realtor and lets just say it didn't go well. When I spoke to Christine she was extremely responsive. I had a list of houses that I had researched online and went out and looked at them myself. I had already chosen the one that I wanted. She was extremely helpful in helping me place my offer and worked hand in hand throughout the buying process! There were several issues that came up and Christine and her staff kept me informed every step of the way! As a Retired First Sergeant, I highly recommend Her and her staff to anyone new to this area, she is very proactive and will help you every step of the way!! Its was a pleasure working with her team!!!
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03/25/2014 - TanjaG
Bought a Single Family home in 2013 for approximately $200K in Grovetown, GA.
Can't say nothing but good things , Christine and Drew made our first home buying experience easy and understanding. We did not feel pressured or nervous. They went above and beyond to help us. Not only did we find a great home in a great location but new friends!
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03/10/2014 - dfisher4321
We connected, but it did not work out. Looking in Snead, Evans, GA 30809
Mrs. May was recommended to me by an national buyers agent organization. I provided her a list of characteristics I was looking for in a home. She was quick to respond and provide several listings. The listing provided did not match our desires. Not one listing provided was even in the school district we desired. After this continued I sent her an email noting I was not going to pursue a home purchase with her. She returned a long ranting email about what an ignorant consumer I was and that she was the professional and knew what was best for me.
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12/20/2013 - qgriffin5
Bought a Single Family home in 2013 for approximately $100K in Blythe, GA.
We purchased a house through Christine and her family. Samantha showed us the house after we asked to look at another one in the area and we fell in love with the house. Christine and Samantha guided us through the paperwork and made sure we closed quickly and easily. All in all a wonderful experience.
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10/09/2013 - jctdbowers
Showed home in 2013 in Jamestown, Hephzibah, GA 30815.
I would like to say all you have to do is tell Mrs May what your wanting in a home and its like she found us the exact home we were looking for. Wow great home great price we will only use her in any futurr endevors.
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