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TextPipe Lite 9.7.3
TextPipe is the ultimate Webmaster tool for updating text. It handles an unlimited number of files and folders, and is unique in handling files of unlimited size. It performs one or more changes AT THE SAME TIME, and can search for MULTI-LINE text and special characters. Search for 'fuzzy' text patterns using popular perl-style regular expressions, and friendly EasyPatterns, with predefined patterns for [Date], [Time], [IPAddress] and more.
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Disc Create Express 4.0.1
The Disc Create Express is truly the most powerful yet simple CD DVD burner which enables you to burn any data (text, image, video, audio and more) from your computer onto CD-R, DVD-R, DVD+R, CD-RW, DVD-RW, DVD+RW, HD DVD and Blu-ray discs; burn AVI, MPEG-1, MPEG-2 and WMVD files to DVD-R/DVD+R discs quickly and easily; burn audio files to audio CD that can be played in any standard CD player with ease; rip audio tracks from your music CDs.
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Recovery Toolbox for Outlook Express 1.8.43
Recovery Toolbox for Outlook Express is the easiest service for Outlook Express recovery that you have ever seen. The utility recovers damaged mailboxes with dbx extension that are not openable by Outlook Express. It works with any version of this email client and parses the source dbx files that correspond with Outlook Express folders. It is the last chance to get back your email after failures and if you have not prepared a copy of mailbox.
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Outlook Express Backup Toolbox 1.1.17
Outlook Express Backup Toolbox quickly makes a full backup of Outlook Express mailbox. It is done in literally several mouse clicks. It works with any version of this email client, try this utility if you'd like to keep your mailbox in safety. There are two available modes for Outlook Express restore, for beginners and more experienced users: Simple and Advanced. By default, all additional settings are turned on, this tool saves everything.
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Express Rip Plus Edition 1.97
Express Rip Plus Edition CD Ripper for Windows is a CD ripping program for Windows. Express Rip provides a useful tool to extract digital audio files from a CD. Express Rip Plus features a user-friendly interface for easy ripping. Express Rip is one of the fastest rippers available and provides perfect digital quality extraction.
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Express Rip CD Ripper Free 1.97
Express Rip Free CD Ripper for Windows is a CD ripping program for Windows. Express Free provides a useful tool to extract digital audio files from a CD. Express Rip Free features a user-friendly interface for easy ripping. Express Rip is one of the fastest rippers available and provides perfect digital quality extraction.
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Web Miner 1.2.5
Avant Prime Web Miner is the ultimate data extraction and web scraping tool. Crawl the web and extract emails, images, URLs, phone numbers, microformats, files and documents, keyword density reports, meta tags plus more. Use your own custom regular expressions or XSLT documents to perform custom data extraction. This tool supports automatic sending of emails, building image & document gallery, automatic posting of artefacts to web services.
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Express Project Free Project Manager 1.10
Project management software for Windows that's free and easy to use. Quickly master project goals and objectives with Gantt charts while staying within your established constraints of scope, time, quality and budget. Effectively monitor and track all project activities to stay up to speed on team member needs to accomplish project goals.
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Mail Mechanic 1.33.1
Recover lost and corrupted email databases and save messages removed from the Deleted Items folder in just a few clicks! Mail Mechanic handles all sorts of issues with individual email messages and email databases in Microsoft Outlook, Outlook Express, and Windows Vista Mail. If your mail database is corrupted or not recognized by an email client, Mail Mechanic will fix the damage by repairing the database.
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SoftAmbulance Live Mail Recovery 4.36
Permanently deleted an important message? Lost access to your email after a system failure? Corrupted DBX database? Install SoftAmbulance Live Mail Recovery to get back your email and restore Outlook Express operation in a matter of minutes! Can't access your mail? Outlook Express does not open? Empty mail folders? No problem! SoftAmbulance Live Mail Recovery fixes major problems as effectively as it handles minor issues.
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Talon Computing Rule Engine Express 1.0
REX is the application name given for Talon Computing Rule Engine Express. As the name suggests, REX is a lightweight rule engine that is used by your development team to process business rules and react to decisions arising from those business rules. REX is a framework for describing business logic for various aspects of your application.
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VISCOM Digital Signage Display Software 8.18
AV Manager is a Digital Signage, Multimedia display, Digital Video Management software which can operate multiple display units ( plasma, LED, LCD displays, VGA projectors and video walls) AV Manager supports various types of contents, such as F4V, M2TS,MPEG-1, MPEG-2, MKV, .DIVX, AVI, WMV, ASF, QuickTime, TV channel, cable TV, web cam, text, BMP, GIF, JPEG image, live events from Microsoft Expression Encoder and RSS Feeder, RSS Scrolling Text. AV Manager supports all these contents running on plasma TVs, LCD displays, LED signs. Display units must be connected to one or more PC workstations that have individual fixed IP address. Therefore contents can be sent to selective display units. Various types of contents are supported, such as MPEG 1 and MPEG 2 video, picture, website, text, digital clock, ad-hoc text message, PowerPoint, Flash File, TV channel or cable TV programs. Sequence feature is to group a number of contents into groups or categories each with a sequence of play-list order, so that use ...
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VISCOM Outlook Express ActiveX OCX SDK 2.69
Browse all the folders of Outlook Express. Extract attachments from Outlook Express message. Export Outlook Express Message to eml file format. View Message in Outlook Express window.Get number of Attachment of each Outlook Express Message. Rename / Move / Delete / Create a folder. Get Message State / Display From / Subject /Received Date. Delete / Copy / Move / Create message. Messages in the specify folder. Add all Contacts to window address book from folder. Create contact in window address book. Browse contacts in window address book. Royalty free distribution of the OCX file. Compatible with any programming language that supports ActiveX (Access, Visual C , Visual Basic , Visual Foxpro, Delphi, .Net, etc.) Include Access, Delphi, VB, VFP, VC Sample code.
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Silverlight .NET Image Viewer SDK 1.63
For .NET Developers who need to imaging SDK on Window and Mac OS X or browser-based application. Silverlight Image Viewer (TIFF, JPEG, BMP, PNG, GIF) and Barcode reader, image processing SDK on Window and Mac OS X or browser-based application. Display BMP, GIF, JPEG, PNG, multi-page TIFF. Save as bmp, JPEG, PNG, multi-page TIFF. Save as bmp, JPEG, PNG, multi-page TIFF with specific size. Save as multi-page TIFF with different compression (LZW, JPEG, CCITT FAX3, No Compression). Save as PDF, Save as multi-page PDF, Save as PDF with custom size, Crop to PDF file (need PDF Encoder plugin). Create PDF file and Insert new page with text and image (need PDF Encoder plugin). Zoom in, Zoom out, Fit to Width, Fit to Height. Image rotation support (0, 90, 180, 270 degrees). Drawing selection rectangle and crop specific part of image. Display Thumbnail List and Set the Thumbnail List Alignment. Image Effects plugin - Support add image effects for full image or selected part of image. Image Effe ...
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Silverlight .NET Video Capture SDK 1.59
For Web or Window Developers who need to Video Capture processing on Window and Mac OS X or browser-based application. Capture Video From WebCam. Snapshot to JPEG file or WriteableBitmap. Programmatically select video device, get the specific video device name and count of video device. Support a lot of Video Effects: 1.Brightntess 2.Contrast 3.Invert 4.BandedSwirl 5.Bloom 6.ColorKey Alpha 7.Color Tone, 8.Directional Blur, 9.Embossed, Gloom, 10.GrowablePoissonDisk, 11.Magnify, Monochrome, 12.Pinch, 13.Ripple, 14.Sharpen, 15.Smooth Magnify, 16.Swirl, 17.Tone Mapping, 18.Toon Shader 19.Zoom Blur 20.Old Movie 21.Transition PixelateIn 22.PaperFold 23.Parametric Edge Detection 24.Pivot 25.Sketch PencilStroke 26.Sketch Granite 27.Splinter 28.Tiler 29.Transparent Alternating Pixels Multiplied 30.Wave Warper 31.Glass Tiles 32.Frosty Outline 33.Apply TextureMap 34.Bands 35.Transition Wave 36.Image Mixing effects. Include Sliverlight c# 2 ...
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TMDBoolean 4.8
A children's program for creating expressions with two simple variables = true or false. Using pictures of animals, compose an expression then add lines to get the desired result, equality.
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Express Invoice Plus Edition 4.10
Express Invoice Plus Edition billing software for managing accounts, billing, quotes, orders, invoicing and applying payments. Make your business excel using web access so multiple users can create invoices, reports and apply billing payments from their web browser. Express Invoice allows you to create templates of recurring invoices for ongoing services and link to credit card billing gateways to easily process payments for goods and services.
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Express Invoice Free Invoicing Software 4.10
Free billing software for managing accounts, billing, quotes, orders, invoicing and applying payments. Make your business excel with an online console so multiple users can create invoices, reports and apply billing payments from their web browser. Express Invoice allows you to create templates of recurring invoices for ongoing services and link to credit card billing gateways to easily process payments for goods and services.
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DBX Recovery Tool 4.02.01
In case of Outlook Express DBX file corruption, all email items like emails, attachments, images, contacts, drafts, notes, sent items, calendars, email properties, etc. become inaccessible. As they hold your crucial email information, they must be recovered as soon as possible at any cost. Repairing severely corrupted DBX database and recovering all mailbox data is not possible manually. For this, you must use a powerful DBX recovery tool like RecoveryFix for Outlook Express. RecoveryFix for Outlook Express is proficient Outlook Express DBX recovery tool which proves its outstanding performance and accurately recovers all email data from corrupt, damaged or inaccessible Outlook Express DBX files. This DBX recovery software extracts mailbox data from damaged Outlook Express Store and saves them in a new DBX or EML file. In addition, this software accurately recovers emails emptied from "Deleted Items" folder and displays them in RED color for easy identification. RecoveryFix for Outlook ...
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Mergemill Pro 4.7.1
Mergemill Pro is a versatile data processing tool. Users may use it to reap the many benefits of generating static web pages, cleanse and de-duplicate data to improve data quality, analyze website traffic logs to obtain crucial web stats, do survey by email without a website, automate the conversion of text file formats and character encodings, monitor web page changes automatically, and freely test and learn powerful regular expressions.
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Recovery Toolbox for Outlook Express Password 1.1.21
The program recovers user account details, stored in Outlook Express email client and provides a password that can unlock this program. Recovery Toolbox for Outlook Express Password saves your account details into a text file or you can copy the source combination and unlock your email account in Outlook Express immediately. It works with any version of this email client and you can easily forget about the system requirements of application.
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Album Express Professional Win 5.9
Album Express 5 Professional is a stand-alone software especifically designed to accelerate the creation and the layout process of high quality digital photo albums.
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Album Express Professional MAC 5.9
Album Express 5 Professional is a stand-alone software especifically designed to accelerate the creation and the layout process of high quality digital photo albums.
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Express Accounts Free Accounting Program 4.91
Free accounting software for small business for simple and easy bookkeeping. Document incoming and outgoing cash flow including sales, receipts, payments and purchases. See how your business is doing with real time balances and reports. Fax or email your accountant directly. Prepare your tax returns quickly with your financial reports. Upgrade to the professional version for remote access and additional features.
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Express Uninstaller 2.5
Did you know that the standard Windows remove program uninstalls an application but does not find or delete leftover files or registry entries? These leftover items serve no purpose but over time they build up and start to slow down your computer. Uninstalling programs with Express Uninstaller is the safe and fast way to remove the application along with all leftover files. Use Express Uninstaller for a clean and thorough uninstall ever time.
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text: Encouraging Language Development in Babies 10 Ways to Encourage Babies to Develop Language Skills by Rebecca Gruber 4/14/11 0 Reactions 115 Shares Print 76 32 7 0 0 Don't tell the producers of The King's Speech, but a few "ums" and "uhs" in mama's daily lexicon may actually be beneficial when talking to tots! According to a new study just released in Developmental Science, the little stumbles in adult language actually help tots learn language more effectively – signaling toddlers' minds that they are about to learn something new. To ensure that your talking tyke is growing his language development skills as much as possible, parents and caregivers must incorporate speaking directly to their children as part of their daily activities. Check out our 10 tips for aiding the development of language in tots. Source: Thinkstock Sing Nursery Rhymes What's Your Reaction? 0 0 0 0 0 0 Though you may prefer to jam to the latest from Beyoncé, nursery rhymes have lasted as long as they have because of their simple words and concepts. As tots' verbal skills develop begin leaving out individual words that they can help you fill in – such as the animal on old MacDonald's farm. Source: Getty 1 / 10 Use Real Words . . . What's Your Reaction? 0 0 0 0 0 0 ...not baby words. Talking to your child in baby talk will only encourage them to use those words when they are able to speak on their own. Use real words, including the correct words for foods, body parts, etc. to get the child used to them. Source: Getty 2 / 10 Read, Read, Read What's Your Reaction? 0 0 0 0 0 0 Reading to a baby from birth has been shown to aid in a love of books and help with language development. When reading to a baby, point out items on the page such as the red wagon or a blue balloon. Source: Getty 3 / 10 Make Eye Contact What's Your Reaction? 0 0 0 0 0 0 Looking your baby in the eye when speaking to her will help her better concentrate on what you are saying. Source: Getty 4 / 10 Use Every Locale as a Learning Experience What's Your Reaction? 0 0 0 0 0 0 A trip to the grocery isn't a simple errand when a baby's in tow. Count the number of potatoes you place in the cart, discuss the color of the apples and tell your youngster the name of everything he points to during the trip. The variety of colors and objects will keep his attention throughout the trip. Source: Getty 6 / 10 Keep Background Noise to a Minimum What's Your Reaction? 0 0 0 0 0 0 Though music is beneficial to children, turn off the radio, iPod and television when engaging in active play with your lil one. Doing so will help her better concentrate on what you are saying and allow her to hear the correct pronunciation of words. Source: Getty 6 / 10 Crank Up the Kiddie Tunes What's Your Reaction? 0 0 0 0 0 0 Yeah, the latest track from Coldplay or Jay-Z may be a bit catchier than Raffi's "Wheels on the Bus," but the kiddie tunes will help your baby learn the necessary words for future speech development. When rolling through town, pop in a CD of nursery rhymes or baby stories to aid in vocabulary development. Source: Getty 7 / 10 Visit Story Times What's Your Reaction? 0 0 0 0 0 0 Though the youngest of children may not be able to sit through an entire story time session, just taking them to one on a regular basis will allow them to see how other kids are listening and learning. Plus, the session will give you some new book ideas. Source: Getty 8 / 10 Go on an Adventure Walk What's Your Reaction? 0 0 0 0 0 0 Taking a hike around your neighborhood or the local park can be more than just fresh air for baby and some exercise for mama. Use the time to describe what you see, the colors, what your plan is for the day, etc. The active – though one-sided – conversation is great for language development. Source: Getty 9 / 10 Make Them Say It What's Your Reaction? 0 0 0 0 0 0 Babies love to point at objects they want. If they are old enough to name what they want – the ball, their milk, etc. – don't give them the object until they say it. If they are too young to verbalize the name of the object, hand it to them while saying the name. Source: Getty 11 / 10 76 32 7 0 0 Read More Health And FitnessListSpeechNews Health and Fitness 10 Safe Sunscreens For Kids (Including Some You Can Find at Your Drugstore) 5/19 Clean Up Your Kids' Eating Habits With 14 Healthy Alternatives 4/17 Alert! Cute and Convenient Carriers For Allergy Meds 2/13 DLVR Maternity Survival Gear Gives You an Excuse to Live in Your Yoga Pants 7/15/13 7 Ways to Make Brushing and Flossing Fun For Kids 5/28/13 5 Reasons to Feed Your Family Organic (and 7 Easy Ways to Do So) 5/23/13 Link Love Mom forced to stop feeding baby homemade formula — BabyCenter Blog The easiest ways to save on organic food — The Stir A look inside Fergie's second baby shower — Celebrity Baby Scoop Danielle Jonas debuts her baby bump — People Moms & Babies 7 light and fresh recipes to take you through Summer — FitPregnancy Does where you live affect your risk for PPD? — The Bump Where to find the best deals on school supplies — Real Simple Now this is how you announce a pregnancy! — HuffPost Parents

subset: commoncrawl


text:
The Ospreys jumped out early on Dolphins starting pitcher Alex McRae (West Allis, Wis./New Berlin Eisenhower) sending eight men to the plate in the first inning. The Ospreys tallied five runs on six hits to jump out to an early 5-0 lead.
The Dolphins answered with a run in the bottom half of the second. Drew Luther (Fullerton, Calif./Fullerton College) singled and advanced third on a single by Kris Molter (Jacksonville, Fla./Bishop Kenny). Jake Huxtable (Winter Springs, Fla./Santa Fe College) then lifted a sacrifice fly to left scoring Luther easily from third.
UNF answered back with a run in the top of the fifth to expand the lead to 6-1.
The Dolphins pushed across a run in the bottom half of the fifth. Garrett Ruckel (Jacksonville, Fla./Stanton College Prep) reached on an error. One out later Zachary Houck (Orange Park, Fla./Eagles View Academy) singled advancing Ruckel to third. Dylan Dillard (Kissimmee, Fla./Osceola) then followed with and RBI single to left to make it a 6-2 game.
That is as close as the Dolphins would get. The Ospreys added a pair of runs in the seventh and followed up with two more in the eight.
The Dolphins scored a run in the bottom half of the seventh. Ethan Loosen (Uniondale, N.Y./FSCJ) reached on a one out single. Houck then followed with a single. Dillard walked loading the bases. Nathan Koslowski (Jacksonville, Fla./Episcopal) ripped an RBI single making it 8-3.
The Dolphins added a run in the bottom half of the ninth. Loosen led off with a double. Dillard singled advancing Loosen to third. Loosen then scored on a wild pitch to round out the scoring at 10-4.
Dillard led the Dolphins offensively. Dillard went 3 for 3 on the day with a walk and an RBI while upping his average to .330 on the season.
Alex McRae (3-5) was tagged with the loss after going five innings allowing nine hits and six runs while striking out four.
Game three of the series is tomorrow at 1pm from John Sessions Stadium. All of the action can be followed live at www.judolphin.com


text:
Emergency crews responded to the scene of a pedestrian struck in Newport on Thursday morning.
It happened around 7:30 a.m. at 9th and Columbia, which is near Newport Middle School.
A male student was struck, but not seriously injured. He was not taken to the hospital.
Copyright 2012 WXIX. All rights reserved.
Hershey Company has unveiled its new corporate logo.
635 W. 7th Street
Cincinnati, OH 45203
Switchboard: (513) 421-1919
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Monday - Thursday 9am - 8pm Friday - Saturday 9am - 5pm Sunday 11am - 3pm 235 32nd Street, Avalon, NJ 08202 609-967-7155
Library Catalog
Classes - Programs
History Center
Library By Mail
Driving Directions
Contact Us
hoopla is here! Instantly access thousands of popular movies, television shows, audiobooks and full music albums on your computer or tablet or smartphone. Watch these brief tutorials for more information, or sign up for an account using your valid Avalon library card and start browsing today!
Note to Windows users: hoopla is compatible with all browsers except Internet Explorer v. 11.
Mango Languages has provided our library with a one-year free trial, featuring the most popular languages in their 60+ language offerings: Spanish, French, Italian, German, Chinese, Japanese, Russian, English for Spanish Speakers and Pirate (we arrrren't kidding!). Try learning a new language today and have fun doing it!


text:
modern living + innovative design + inspiring ideas
Dart Modern Bronze 21-Inch-WPendant Light
"If you don't include at least one geometric design in your home, shame on you!"
- P. Daniels, Photo Stylist
About Euro Style Home
Dwell on Design
Fresh Home
My Modern Met
Blog Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.
From our Euro Style Lighting family to yours, we wish you a very Happy New Year!
Image: Geronimo Balloons
With the holiday season coming to a close it's time to take the Christmas cards and heaps of greenery down. Are you looking around your home at the blank spaces where the Christmas tree once stood or the greenery once laid? . . . Well, it's time to get your home looking refreshed with new modern accessories that will make your home feel spruced up. Although it might feel a little toned down from all of those holiday decorations, I think staying with a neutral color scheme is important because it makes for an easy transition now. In the Spring you'll want to layer on the bright bold colors.
Here are a few of my favorite accessories that will have your home feeling jazzed up for the rest of the Winter.
Jamie Young Leather Strap 19" High Round Wall Mirror
Are you looking at that empty space on your wall and longing for something to fill it? I have lots of little spaces like that in my home (especially where my tree once stood). Contemporary mirrors are a great addition and this Jamie Young round mirror would work well in any space. The leather cowhide frame makes for a wonderful detail that sets this mirror apart from a normal silver frame.
Round Silver Sunburst on Stand
All right, you might think I'm a bit crazy – I promise I'm not. For those of you who don't use your fireplaces or don't have a working fireplace this is the item that will make your empty space look unique. I've used similar sunburst objects in client's homes and they look fabulous.
Nambe Crystal 6" Wide Butterfly Bowl
In my eyes crystal bowls can be used two ways – as art work and for serving. Which means this beautiful Nambe bowl could be used to store your Winter accessories on a mantel or coffee table.
Brighton Iron and Leather Wine Holder
Do you have leftover wine lying around from hosting parties? A small wine rack next to your bar for those bottles of Pinot Noir or Sauvignon Blanc will remind you to grab one as you walk out the door to a party or open a bottle after a long day at the office.
Braided And Lattice Design Matte White Small Diana Vase
Last but not least, vases are one of my favorite accessories to decorate with – I use them empty or with a beautiful arrangement. This stunning ceramic with lattice texture would be perfect for a coffee table or console.
Now that you've seen a few of my favorites, do you have any post holiday accessories you're decorating with right now?
Image: Desire to Inspire
+You've got to see this museum shaped like a tub. It's actually attached to the older building next to it and the contrast is amazing (the interior is even cooler)!
+For those of you starting the new year off with healthy intentions, Refinery 29 provides a great list of the best L.A. juice bars.
+Have you seen The Hobbit yet? Well, chances are you don't like it as much as Maddie Chambers who built a hobbit dollhouse!
+If you're in the mood for some great photography and you can't make it to NY for the Ann Hamilton 'The Event of a Thread', then head over to Whimsey + Spice, where Jenna Park shares her photos of the art installation.
+In other news, there's a giant rubber ducky drifting through Syndney's Darling Harbour.
Image: LA Times
January, 2013
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text:
a ponderous research paper by four scholars writing under the aegis of National Bureau of Economic Research (the entity that decides, officially, when recessions start and end).But it's not intelligence that interests them. It's how popular you were (or weren't) in high school. Does such popularity in any way relate to your earning potential as an adult? And if does, how determinative might it be?
Read more http://feeds.abcnews.com/click.phdo?i=16eb5261235f5f32ca67ff1c7d9df57e


text:
LOUISVILLE, Ky. (WDRB) – The University of Louisville continued its push toward the top of the Big East standings Saturday, dispatching Seton Hall, 79-61, at the KFC Yum! Center.
With Georgetown winning at Syracuse and Marquette falling to Villanova, Louisville is tied with the Orange and the Golden Eagles for second place, one game behind Georgetown. The three-way tie won't last long. Syracuse plays at Marquette Monday night.
Georgetown plays at Connecticut Wednesday, the same night Louisville visits DePaul in Chicago.
The Cards enjoyed one of their best three-point shooting nights of the season, making seven of 15. Luke Hancock was three for three and Kevin Ware made two of five. After a 9 for 41 start from the three-point line, Hancock has made 29 of his last 71 threes (41 percent).
Russ Smith and Gorgui Dieng also had solid nights. Smith finished with 19 points while Dieng had 23, making all but one of his 11 field-goal attempts. He also had three blocks. Smith was a perfect 10 of 10 from the free-throw line.
The game against the Pirates was the second in a three-game stretch against the three bottom teams the Big East. Louisville defeated last-place South Florida Sunday and gets DePaul next.
LEAGUE LEADERS – Here is where Louisville players rank among the Big East statistical leaders:
Russ Smith, second in scoring, 18.4; Chane Behanan, fourth in rebounding, 7.4; Behanan, ninth in field goal percentage, 50.7; Peyton Siva, third in assists, 6.08; Siva, third in steals, 2.08; Smith, fourth in steals, 2.04; Siva, second in free throw percentage, 87.7.
DOUBLE DIGITS -- The victory upgraded Louisville's league record to 10-4, making it the seventh straight season the Cardinals have won 10 or more Big East games.
FAMILY TREE – Former U of L assistant Kevin Willard, one of 25 former Pitino assistants or players who has become a head coach, coaches Seton Hall. Nine are currently head coaches of Division I programs.
The victory improved Pitino's record to 6-0 against Willard and 32-9 against the group.
WHERE IS THE LOVE? – Rick Pitino's players have only been honored twice in 14 weeks in the Big East player of the week and freshman of the week awards. U of L guard Russ Smith was selected at the player of the week on Dec. 31 after the Cards' victory over Kentucky, and Chane Behanan was the pick on Dec. 17.
The only two Big East players to honored twice are Cincinnati guard Sean Kilpatrick and Shabazz Napier of Connecticut.
JaKarr Sampson of St. John's has been the freshman of the week selection six times.
FOOTBALL SIGHTING – Charlie Strong's football staff was in the house – along with nearly 60 top prospects from the Class of 2014.
HARLEM SHAKE – Louisville rolled out its edition of the "Harlem Shake," video last week, and the spot was featured on the video board early in the second half. As of early Saturday afternoon, the video had inspired more than 504,000 views on YouTube.com.
UP NEXT – Louisville completes its conference road schedule next week. The Cardinals visit Chicago to play DePaul Wednesday night and then travel to Syracuse to play the Orange on Saturday. Louisville has won nine straight against the Blue Demons.
Copyright 2013 WDRB News. All Rights Reserved.
624 W. Muhammad Ali BlvdLouisville, KY 40203


text:
My granny
Prayer Requests, Family Announcements, Weddings, Anniversaries, Birthdays, etc.
Moderator: Team Cub
13 posts • Page 1 of 1
My granny
My granny is in the hospital with congestive heart failure. It don't look good so yur prayers will be appreciated thanks
He that tilleth his land shall be satisfied with bread: Proverbs 12:11
Re: My granny
Prayers sent from Michigan
1929 Farmall Regular
1935 John Deere B
1937 John Deere A
1941 John Deere H
1952 John Deere B
1953 Farmall Cub
Re: My granny
yall are in our prayers David!!
Re: My granny
prayers on the way.
1975 cub (LouAnn) serial # 245946, 1941 John Deere Model H
Good judgment comes from experience,
and a lot of that comes from bad judgment. Will Rogers
Re: My granny
You and yours are in our prayers. May the Lord bless you all with what you will need according to His plans (+)
Confusion breeds Discussion which breeds Knowledge which breeds Confidence which breeds Friendship
Re: My granny
Prayers on the way!
Re: My granny
Prayers on the way from Tenn.
Re: My granny
Prayers for you and all of your family from Arkansas
Re: My granny
Prayers from Western Arkansas. May God Bless.
Guiena, 1951 Farmall Cub; Jumping Willy, 1949 Farmall Cub.
Re: My granny
Prayers lifted from Va.
I started out with nothing and now I only have half of that left !
Re: My granny
Sorry to hear about this. Sandra and I are with you and your family at this time.
If you can't find it, don't lose it.
Re: My granny
Bev and I both are praying for her.
"Life's tough.It's even tougher if you're stupid."
- John Wayne
" We hang petty thieves and appoint the great ones to public office."
- Aesop
Re: My granny
Prayers up from the Ozarks.
High atop Hummingbird Hill
In the Missouri Ozarks
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Some Detroit party store customers were horrified to see their pictures on social media sites with racist comments. They called Fox 2 looking for answers.People who think racism is wrong and disgraceful will be disgusted and sickened by this. Cell phone pictures were taken of black customers who did not know they were being disrespected, and some of them were kids.Watch Andrea Isom's video report for more on this story.
WTXF-TV330 Market StreetPhiladelphia, PA 19106-2796Phone: (215) 925-2929Fax: (215) 982-5494


text:
OLYMPIA, WA - Small,
rural school districts could transition to a money-saving, four-day school week
if a bill proposed by Sen. Curtis King, R-Yakima, becomes
Bill 6242 would make permanent a 2009 pilot program set to expire this year
that allows up to five school districts with fewer than 500 students to condense
their school week.
"The communities of Bickleton and Paterson have taken
advantage of this pilot program and found it to be an excellent cost-saver,"
King said. "In talking with the superintendents of these school districts, they
have found the shortened week has not affected their educational standards and
they've been able to maintain the same level of quality education as before.
It's really working well for them, and my bill will allow them to keep
King added that the Bickleton school district has reported a
100-percent graduation rate and a zero percent dropout rate since changing to
the four-day school week. King also noted that there are still three other slots
available for school districts with fewer than 500 students to participate in
the program, and those slots will remain open if SB 6242 is approved by the
House of Representatives.
"Now that my bill has passed the Senate unanimously, I'm
looking forward to helping it make its way through the House committees and
finally to a vote of the full body," King said.
SB 6242 has already been scheduled for a public hearing in
the House Committee on Education at 8 a.m. tomorrow.


text:
BOSTON (KNOE 8 News/AP) - Residents of the Northeast who have already had enough winter to last them a while are getting another dose of snow, sleet and freezing rain.
The second storm of the week is canceling classes, closing government and business offices and causing power outages across the region. The storm had a similar impact yesterday in the Midwest.
Anywhere from a few inches to a foot or more of snow is expected to fall today on East Coast states. Some are getting freezing rain and sleet that is making driving treacherous. It's the region's second go-round since Monday.
Massachusetts is bracing for six to 12 inches of snow. It started falling in western parts of the state before dawn. Boston and other communities have closed schools and banned street parking to prepare for snow removal. Some non-essential Massachusetts state employees have been told to stay home.
A mix of snow and freezing rain began falling after midnight in the New York area. Manhattan could get three to six inches of snow, and up to a half-inch of ice. In upstate New York, hundreds of schools are closed and authorities are advising against any unnecessary travel.
Icy conditions have knocked out power to more than 200,000 electric customers in southeastern Pennsylvania. Nearly 30,000 homes and businesses in New Jersey are without power.
To the west, much of Ohio got four to eight inches of snow overnight. Many counties declared snow emergencies. Freezing rain and ice that moved through Kentucky overnight left thousands without power.


text:
Marine Protein 700mg 100 V caps
OTHER SIZES click to show/hide additional sizes & quantities
About Ingredients:
- MARINE PROTEIN 700 mg
MARINE PROTEIN 700 mg
Freeze-dried Anchovy or sardine, Natural Vitamin E (as an...
A Safer Way to Eat Fish
Protein Source: Seagate has developed a unique freeze-dried 75% protein concentrate from whole sardines and anchovies. Seagate harvests these fish along the Pacific coast of Baja California, part of an abundant stable resource. These species inhabit the lower level of the marine food chain and therefore are free of toxins and contaminants found in the predator species such as shark, swordfish and tuna.
Suggested Use: There is no better source of protein than fish, as long as the fish are pure. Nine (vegetable) capsules of Marine Protein per day provide 5 grams of protein, equal to approx. 10-15% of the adult daily protein requirement plus 246 mg. of omega-3 fatty acids. Marine Protein is ground into a very fine powder that is easy to digest, providing quick absorption and assimilation.
Processing: The fish are cooked, pressed, freeze-dried, and ground into powder in Seagate's state-of-the-art manufacturing facility. Seagate controls each step of processing.
Purity: This product has been laboratory-tested and contains no mercury, pesticides, or PCBs. The fish used in this product are plankton-feeders, a level of the marine food chain that has not yet been subjected to the accumulation of toxins that may be found in larger fish species.
Benefits: Marine Protein is a safe and convenient way to receive the full nutritional benefits from eating whole fish while eliminating the cooking, tasting and chewing. Marine Protein is a very rich source of amino acids with only 26 calories per serving.
A nine capsule serving provides the following essential amino acids(in mgs):
Isoleucine 199
Lysine 454
Phenylalanine 215
Tryptophan 58
Leucine 402
Methionine 151
Threonine 156
Valine 198
Cystine 51
Histidine 167
Arginine 315
Glycine 227
Aspartic Acid 308
Serine 163
Glutamic Acid 596
Proline 200
Hydroxyproline 14
Alanine 291
Tyrosine 181
These capsules are easily stored at home or packed on trips, and can be taken in larger quantities as a temporary meal substitute during emergencies.
Nutrition Facts
Review Snapshot
Average Customer Rating (based on 2 reviews)
Already own it? Write a Review
Awesome results
By: Donna from Muncie, IN US on January 23, 2010
"I purchased the Marine Minerals and the Broccoli capsules and shared them with my daughter. She was suffering from back pain for months to the point of depression. My intention was for her to just take them for better health but to our surprise her back has not bothered her and she said her anxiety has also decreased. What a bonus. We don't understand it but we will take it!!"
20 of 34 people found this review helpful. Was this review helpful to you? Yes | No
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Heading out to see the relatives this Thanksgiving? Before you travel over the river and through the woods to Grandmother's house, check out these sanity-saving tips to make your ROADTRIP stress-free and even fun. (If you are flying instead of driving, check out my tips on How to Have Fun at the Airport with Kids in Tow.)
Tip: Make a List
Make a list of everything you'll need on the trip for everyone in the family. If it's on the list, you won't forget it. To make it easier, download a free Family Vacation Packing List and then add your unique items.
Tip: Plan the route ahead of time.
By taking a little time up front to plan the route including places to stop for bathroom breaks or energy stops, you might feel a little more in control before you ever set foot in the car. To find the cleanest restrooms, download the free Sit or Squat app for your phone.
Tip: Plan Some Fun Stops
If you are driving more than 4 hours, plan some stops to reenergize the bored family. Check out RoadsideAmerica.com, a site dedicated to helping you find those amusing road side attractions. You know, like the World's Largest Ball of Twine or Flipper the Dolphin's Grave. (I'm not making that up.)
Tip: Don't Leave Home without These
Snacks - No messy or crumbly snacks for the kids! Unless you want to start an all-you-can-eat snack bar under the back seats, little, individual size snack bags work perfect. Grapes are good, easy to eat and no peel to worry about. Skip the juice boxes, too. Put drinks in drip-proof sippy cups or sports bottles so they don't leak or get squirted everywhere.
Water Bottles – Always have at least one bottle of water in the car. Even if you don't drink it, it's nice to be able to rinse off your hands or that binky that fell in the back seat and is now covered in dog hair.
Garbage Bag – Always have a bag in the car to throw out trash. Trust us, you don't want to hold a snotty Kleenex or ketchup covered wrapper or banana peel for 4 hours. (Been there. Done that. Not fun.)
Pillows, Snuggle Buddies, or Neck Wraps – If the stars are aligned and Holiday fortune is smiling on you, your young kids will fall asleep for awhile. (When they are older, they put their iPod headphones on and they may as well be asleep.) While most kids are resilient and flexible, they shouldn't have to kiss their navel while they are napping. Give them some support.
Antibacterial Wipes/Hand Sanitizer – Buy it in bulk.
Boredom Bag – You'll need plenty of entertainment to keep the kids (and adults) amused for the long haul. Read my post on How to Keep Kids Amused on Car Trips.
For more, check out all of my family travel tips and fun ideas.
What items do you take on your Holiday Road Trips that you can't live without? How do you keep everyone in the family from getting bored in the car?


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Information contained on this page is provided by an independent third-party content provider. WorldNow and this Station make no warranties or representations in connection therewith. If you have any questions or comments about this page please contact email@example.com.
SOURCE Orexigen Therapeutics, Inc.
SAN DIEGO, June 13, 2014 /PRNewswire/ -- Orexigen® Therapeutics, Inc. (Nasdaq: OREX) today announced that management will present a company overview at the Wells Fargo Securities 2014 Healthcare Conference in Boston. The presentation is scheduled for Wednesday, June 18th at 1:50 p.m. EDT. To listen to the live webcast or a replay of the presentation, please visit the Investor Relations section of the Company's Web site at www.orexigen.com. A replay will be available for 14 days after the event.
About Orexigen Therapeutics Orexigen Therapeutics, Inc. is a biopharmaceutical company focused on the treatment of obesity. The Company's lead product candidate is NB32. Based on successful results of the Light Study, an ongoing cardiovascular outcomes trial, Orexigen's strategy for NB32 is to pursue approvals worldwide and pharmaceutical partnerships for global commercialization. The Company has submitted applications for marketing authorization in the United States and Europe, with potential approvals in 2014. If approved, North American partner Takeda Pharmaceuticals will commercialize NB32 in the United States. The Company's other product candidate, Empatic™, has completed Phase 2 clinical trials. Further information about the Company can be found at www.orexigen.com.
Orexigen Contact:
Media Contact:
McDavid Stilwell
Denise Powell
VP, Corporate Communications and Business Development
(858) 875-8629
(510) 703-9491
©2012 PR Newswire. All Rights Reserved.


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>Brookings Oregon News, Sports, & Weather | The Curry Coastal Pilot
|County Jail Log June 15, 2013
|Written by The Curry Coastal Pilot
|June 15, 2013 01:06 pm
The following information is taken from the daily logs (http://justice.co.curry.or.us/arrestlog.pdf) of local law enforcement agencies. Charges listed are preliminary and are made at the discretion of the arresting officer or agency. Charges may be amended or dropped at the discretion of the district attorney or courts.
Tuesday, June 11
Scott Ingram McBroom, 53, Gold Beach, for harassment. Bail set at $5,000.
Wednesday, June 12
Larry Daniel Klamroth, 23, Gold Beach, on a warrant for first degree theft, parole violation, criminal trespass and criminal mischief.
Jared Michael Clark, 39, Brookings, for contempt of court. No bail.


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In an op-ed for AOL News, Professor David Reiss discusses the future of the failing mortgage giants, Fannie Mae and Freddie Mac. Urging Congress and the Obama administration to take radical action, he argues that the hybrid model of Fannie Mae and Freddie Mac are no long needed into today's economic world. Professor Reiss explains, "Fannie and Freddie are not, however, integral to a healthy market for residential mortgages, and we now have an opportunity to fundamentally reshape housing finance policy so that it meets the needs of American homeowners and taxpayers."
Read the full article.
Read the latest issue of BLS LawNotes
"Brooklaw," the BLS Seal, and Logo are service marks of Brooklyn Law School. Contents Copyright © 1995-2013 Brooklyn Law School. All rights reserved.


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CATEGORIES MoviesJeffrey Wright -- in Toronto over the weekend plugging the upcoming 'Ides of March' -- revealed that he probably won't appear in the next James Bond film, still using the working title of 'Bond 23.' His character -- CIA agent Felix Leiter -- appeared in both 'Casino Royale' and 'Quantum of Solace.' [Coming Soon]
Nyuck, nyuck, nyuck. After years of delays and false starts, 'The Three Stooges' finally has a calendar position. Twentieth Century Fox as set April 4, 2012 for the Farrelly Brothers-directed comedy, with Sean Hayes, Chris Diamantopoulos and Will Sasso starring as Larry, Mo and Curly, respectively. TV vets Larry David, Jane Lynch and Sofia Vergara round out the cast. [Deadline]
Speaking of release dates: Summit Entertainment has set Aug. 10, 2012 for 'Step Up 4,' the latest dance revolution film in the surprisingly lucrative franchise. The latest incarnation heads to Miami and focuses on a rich businessman's dance-happy daughter and the boy she loves from the wrong side of the tracks. No word yet on whether 'Step Up 4' will -- like 'Spy Kids 4' before it -- appear in "4-D." Smell those dance moves! [Coming Soon]
Late Friday, Fox Searchlight picked up controversial festival fave 'Shame' for distribution later this year. The film -- from 'Hunger' director Steve McQueen -- stars Michael Fassbender as a sex addicted New Yorker, Carey Mulligan as his sister and reportedly features enough nudity and sex to potentially warrant an NC-17 rating. The awards-season player has already earned Fassbender the Best Actor trophy from the Venice Film Festival. [Press Release]
Adorable 'Crazy, Stupid, Love.' scene stealer Analeigh Tipton, Dave Franco (James's brother) and Cory Hardrict have joined the cast of 'Warm Bodies' opposite Nicholas Hoult, Teresa Palmer, Rob Corddry and John Malkovich. The film follows a zombie (Hoult) who falls in love with the still-human girlfriend (Palmer) of one of his victims. Jonathan Levine, '50/50' fame, directs. [Variety]
After an 18-month battle with non-Hodgkin lymphoma, 'Spartacus: Blood and Sand' star Andy Whitfield passed away yesterday. The 39-year-old actor leaves behind a wife and two children. His wife, Vashti Whitfield, released this statement: "[Andy] passed peacefully surrounded by love. Thank you to all his fans whose love and support have help carry him to this point. He will be remembered as the inspiring, courageous and gentle man, father and husband he was." Whitfield appeared in two films -- the 2007 fantasy thriller 'Gabriel' and the 2010 horror film 'Clinic' -- but he was best known for his work on the small screen. Mo Ryan of AOL TV has more details on this tragic development. [AOL TV]
Photo: Frederick M. Brown/Getty Images


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September 20, 2007
Homerville - People in Clinch County say they're ready for the investigation of the Alapaha Judicial Circuit to be over.
Sissy Suggs, resigned as deputy sheriff Monday.
Acting Clerk of Court Melinda Davis will also resign by October 31st.
Davis took over as Clerk of Court last month after former clerk Danny Lecesse pled guilty to a federal mail fraud charges.
An audit said they were three of five county employees who collected money from a secret account created by Alapaha Judicial Circuit Chief Judge Brooks Blitch.
Over 73 thousand dollars has been collected since 1992, funded by the illegal collection of fees from misdemeanor defendants.
They all must make restitution payments for the amount of money they collected.
No one we spoke with in Homerville agreed to go on camera but most people said they hope the investigation will end soon so the county can get back to normal.
Feedback: email@example.com?subject=clinch
P.O. Box 3130
Albany, GA 31706
(229) 446-1010
FCC Public File
(229) 446-4005
EEO Report
Closed Captioning


text:
Sloppy Joe Pasta Recipe
- 1 pound ground turkey or beef
- 1 envelope sloppy joe mix
- 1 cup water
- 1 can (8 ounces) tomato sauce
- 1 can (6 ounces) tomato paste
- 1 package (7 ounces) small shell pasta, cooked and drained
- 1 cup (8 ounces) 4% cottage cheese
- 1/2 cup shredded cheddar cheese
- In a large saucepan, cook beef over medium heat until no longer pink; drain. Stir in the sloppy joe mix, water, tomato sauce and paste. Bring to a boil. Reduce heat; simmer, uncovered, for 5-8 minutes or until heated through. Remove from the heat; stir in pasta.
- Spoon half into a greased 2-1/2-qt. baking dish. Top with cottage cheese and remaining pasta mixture. Sprinkle with cheddar cheese.
- Bake, uncovered, at 350° for 30-35 minutes or until bubbly and cheese is melted. Yield: 4-6 servings.
Reviews for Sloppy Joe Pasta
Sort By :
My mother has been making this for over 30 years..A few differences in the recipe: Mix the cottage cheese in after you add the Large Shell Noodles to the sauce. Also mix in about 1/2 cup sharp cheddar cheese. Bake for 35 - 40 Minutes then top with cheese to your liking bake additional 10-15 minutes. If you mix this with Ragu you won't have Sloppy Joe Casserole. I usually double up on the recipe and serve with Salad. My family loves this and my husband loves the leftovers for lunch!
I originally found this recipe a couple of years ago in a Taste of Homes magazine and have been making it ever since. It's awesome and the kids really love this one as does everyone else. I always add a little parmesan in with the cheddar on top and it gives it just a little more depth.
love this. One of the few casseroles I make that my husband actually requests.
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styledotcom What to wear and where to go this weekend: stylem.ag/1lwqNC5 #LaborDay pic.twitter.com/tkwbLhmdRA
Leave it to the queens to do Halloween in style. Last night at MoMa PS1, Humberto Leon and Carol Lim along with Luis Venegas of Candy magazine hosted an art-meets-fashion Halloween drag ball, complete with an old-school pageant. "This is Miss America on steroids," proclaimed MC Ladyfag before letting the contestants loose on a makeshift catwalk.
Later, Ladyfag explained, "It's really a celebration of a culture that always dresses up. Most of the people here do this every day. It's nice for people to stop and think what really goes into all of this all the time—how much work it is being a drag queen!" The work was evident in the hundreds of elaborate, detailed transformations—a sparkling, towering mummy bride; a red-lip-smeared Horn of Plenty; and co-host Melissa Burns as Prince. Also in the crowd: a well-disguised Michael Stipe and Justin Bond. "This look? I wanted to make it a bit Saint Laurent grunge, but at the same time I thought it would be cool to have something that would remind people a bit of Norman Bates' mother—Norman from Psycho," explained Venegas of his ladylike, lace-collared flower frock. "You know I come from Spain, so to be in New York celebrating Halloween with a drag ball is quite amazing for me!"
"It's a total mess, but it's great!" added Swedish pop star Robyn from beside the tequila bar. "I just think people are having a good time."
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Brandon Lyon received a three-year, $15 million contract out of the Houston Astros prior to the 2010 season, and while that seemed to be a little pricey for a middle reliever, the Astros outfoxed us all by making him a closer. Pretty inexpensive for a closer, hmmm?
Lyon then pitched like Brandon Lyon, not striking a lot of hitters out and not giving up too many runs -- there's an argument that Brandon Lyon might be the most average reliever of all-time. Though he had an awful first game of the season, he settled down to do more Brandon Lyon things before he went on the disabled list with shoulder weakness. Though he rested most of May, things got even worse when he returned, as he pitched three innings and gave up eight earned runs.
Turns out he was hurt. Really hurt. He was actively avoiding using his right arm around the house, and he was fighting through a rotator cuff tear in addition to upper arm pain. And now he'll see Dr. James Andrews for a unique procedure to put Lyon's biceps tendon back in its groove. In other news, Brandon Lyon should totally nickname his tendon "Stella."
The surgery will knock Lyon out for the year, and Mark Melancon will continue on as the Astros' closer.


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When you are running AnalyzeCovariates to analyze your BQSR outputs, you may run into an error starting with this:
org.broadinstitute.sting.utils.R.RScriptExecutorException: RScript exited with 1. Run with -l DEBUG for more info.
The main reason why this error often occurs is simple, and so is the solution. The script depends on some external R libraries, so if you don't have them installed, the script fails. To find out what libraries are necessary and how to install them, you can refer to this FAQ article.
One other common issue is that the version of ggplot2 you have installed is very recent and is not compatible with the BQSR script. If so, download this file and use it to generate the plots manually according to the instructions below.
If you have already checked that you have all the necessary libraries installed, you'll need to run the script manually in order to find out what is wrong. To new users, this can seem complicated, but it only takes these 3 simple steps to do it!
-l DEBUG (that's a lowercase L, not an uppercase i, to be clear) and
-csv my-report.csv (where you can call the .csv file anything; this is so the intermediate csv file will be saved).
The snippet below shows you the components of the R script command line that AnalyzeCovariates uses.
INFO 18:04:55,355 AnalyzeCovariates - Generating plots file 'RTest.pdf'
DEBUG 18:04:55,672 RecalUtils - R command line: Rscript (resource)org/broadinstitute/gatk/utils/recalibration/BQSR.R /Users/schandra/BQSR_Testing/RTest.csv /Users/schandra/BQSR_Testing/RTest.recal /Users/schandra/BQSR_Testing/RTest.pdf
DEBUG 18:04:55,687 RScriptExecutor - Executing:
DEBUG 18:04:55,688 RScriptExecutor - Rscript
DEBUG 18:04:55,688 RScriptExecutor - -e
DEBUG 18:04:55,688 RScriptExecutor - tempLibDir = '/var/folders/j9/5qgr3mvj0590pd2yb9hwc15454pxz0/T/Rlib.2085451458391709180';source('/var/folders/j9/5qgr3mvj0590pd2yb9hwc15454pxz0/T/BQSR.761775214345441497.R');
DEBUG 18:04:55,689 RScriptExecutor - /Users/schandra/BQSR_Testing/RTest.csv
DEBUG 18:04:55,689 RScriptExecutor - /Users/schandra/BQSR_Testing/RTest.recal
DEBUG 18:04:55,689 RScriptExecutor - /Users/schandra/BQSR_Testing/RTest.pdf
So, your full command line will be:
RScript BQSR.R RTest.csv RTest.recal RTest.pdf
Please note:
For new users, the easiest way to do this is to do it from within an IDE program like RStudio. Or, you can start up R at the command line and run it that way, whatever you are comfortable with.
You may have noticed that a lot of the scores that are output by the GATK are in Phred scale. The Phred scale was originally used to represent base quality scores emitted by the Phred program in the early days of the Human Genome Project (see this Wikipedia article for more historical background). Now they are widely used to represent probabilities and confidence scores in other contexts of genome science.
In the context of sequencing, Phred-scaled quality scores are used to represent how confident we are in the assignment of each base call by the sequencer.
In the context of variant calling, Phred-scaled quality scores can be used to represent many types of probabilities. The most commonly used in GATK is the QUAL score, or variant quality score. It is used in much the same way as the base quality score: the variant quality score is a Phred-scaled estimate of how confident we are that the variant caller correctly identified that a given genome position displays variation in at least one sample.
In today's sequencing output, by convention, Phred-scaled base quality scores range from 2 to 63. However, Phred-scaled quality scores in general can range anywhere from 0 to infinity. A higher score indicates a higher probability that a particular decision is correct, while conversely, a lower score indicates a higher probability that the decision is incorrect.
The Phred quality score (Q) is logarithmically related to the error probability (E).
$$ Q = -10 \log E $$
So we can interpret this score as an estimate of error, where the error is e.g. the probability that the base is called incorrectly by the sequencer, but we can also interpret it as an estimate of accuracy, where the accuracy is e.g. the probability that the base was identified correctly by the sequencer. Depending on how we decide to express it, we can make the following calculations:
If we want the probability of error (E), we take:
$$ E = 10 ^{-\left(\frac{Q}{10}\right)} $$
And conversely, if we want to express this as the estimate of accuracy (A), we simply take
$$ \begin{eqnarray} A &=& 1 - E \nonumber \ &=& 1 - 10 ^{-\left(\frac{Q}{10}\right)} \nonumber \ \end{eqnarray} $$
Here is a table of how to interpret a range of Phred Quality Scores. It is largely adapted from the Wikipedia page for Phred Quality Score.
For many purposes, a Phred Score of 20 or above is acceptable, because this means that whatever it qualifies is 99% accurate, with a 1% chance of error.
|Phred Quality Score
|Accuracy (1 - Error)
|1/10 = 10%
|1/100 = 1%
|1/1000 = 0.1%
|1/10000 = 0.01%
|1/100000 = 0.001%
|1/1000000 = 0.0001%
And finally, here is a graphical representation of the Phred scores showing their relationship to accuracy and error probabilities.
The red line shows the error, and the blue line shows the accuracy. Of course, as error decreases, accuracy increases symmetrically.
Note: You can see that below Q20 (which is how we usually refer to a Phred score of 20), the curve is really steep, meaning that as the Phred score decreases, you lose confidence very rapidly. In contrast, above Q20, both of the graphs level out. This is why Q20 is a good cutoff score for many basic purposes.
Detailed information about command line options for BaseRecalibrator can be found here.
The tools in this package recalibrate base quality scores of sequencing-by-synthesis reads in an aligned BAM file. After recalibration, the quality scores in the QUAL field in each read in the output BAM are more accurate in that the reported quality score is closer to its actual probability of mismatching the reference genome. Moreover, the recalibration tool attempts to correct for variation in quality with machine cycle and sequence context, and by doing so provides not only more accurate quality scores but also more widely dispersed ones. The system works on BAM files coming from many sequencing platforms: Illumina, SOLiD, 454, Complete Genomics, Pacific Biosciences, etc.
New with the release of the full version of GATK 2.0 is the ability to recalibrate not only the well-known base quality scores but also base insertion and base deletion quality scores. These are per-base quantities which estimate the probability that the next base in the read was mis-incorporated or mis-deleted (due to slippage, for example). We've found that these new quality scores are very valuable in indel calling algorithms. In particular these new probabilities fit very naturally as the gap penalties in an HMM-based indel calling algorithms. We suspect there are many other fantastic uses for these data.
This process is accomplished by analyzing the covariation among several features of a base. For example:
These covariates are then subsequently applied through a piecewise tabular correction to recalibrate the quality scores of all reads in a BAM file.
For example, pre-calibration a file could contain only reported Q25 bases, which seems good. However, it may be that these bases actually mismatch the reference at a 1 in 100 rate, so are actually Q20. These higher-than-empirical quality scores provide false confidence in the base calls. Moreover, as is common with sequencing-by-synthesis machine, base mismatches with the reference occur at the end of the reads more frequently than at the beginning. Also, mismatches are strongly associated with sequencing context, in that the dinucleotide AC is often much lower quality than TG. The recalibration tool will not only correct the average Q inaccuracy (shifting from Q25 to Q20) but identify subsets of high-quality bases by separating the low-quality end of read bases AC bases from the high-quality TG bases at the start of the read. See below for examples of pre and post corrected values.
The system was designed for users to be able to easily add new covariates to the calculations. For users wishing to add their own covariate simply look at QualityScoreCovariate.java for an idea of how to implement the required interface. Each covariate is a Java class which implements the org.broadinstitute.sting.gatk.walkers.recalibration.Covariate interface. Specifically, the class needs to have a getValue method defined which looks at the read and associated sequence context and pulls out the desired information such as machine cycle.
Detailed information about command line options for BaseRecalibrator can be found here.
This GATK processing step walks over all of the reads in
my_reads.bam and tabulates data about the following features of the bases:
For each bin, we count the number of bases within the bin and how often such bases mismatch the reference base, excluding loci known to vary in the population, according to dbSNP. After running over all reads, BaseRecalibrator produces a file called
my_reads.recal_data.grp, which contains the data needed to recalibrate reads. The format of this GATK report is described below.
To create a recalibrated BAM you can use GATK's PrintReads with the engine on-the-fly recalibration capability. Here is a typical command line to do so:
java -jar GenomeAnalysisTK.jar \ -T PrintReads \ -R reference.fasta \ -I input.bam \ -BQSR recalibration_report.grp \ -o output.bam
After computing covariates in the initial BAM File, we then walk through the BAM file again and rewrite the quality scores (in the QUAL field) using the data in the
recalibration_report.grp file, into a new BAM file.
This step uses the recalibration table data in recalibration_report.grp produced by BaseRecalibration to recalibrate the quality scores in input.bam, and writing out a new BAM file output.bam with recalibrated QUAL field values.
Effectively the new quality score is:
Following recalibration, the read quality scores are much closer to their empirical scores than before. This means they can be used in a statistically robust manner for downstream processing, such as SNP calling. In additional, by accounting for quality changes by cycle and sequence context, we can identify truly high quality bases in the reads, often finding a subset of bases that are Q30 even when no bases were originally labeled as such.
Note that the BasRecalibrator no longer produces plots; this is now done by the AnalyzeCovariates tool.
The recalibration report is a [GATKReport](http://gatk.vanillaforums.com/discussion/1244/what-is-a-gatkreport) and not only contains the main result of the analysis, but it is also used as an input to all subsequent analyses on the data. The recalibration report contains the following 5 tables:
This is the table that contains all the arguments used to run BQSRv2 for this dataset. This is important for the on-the-fly recalibration step to use the same parameters used in the recalibration step (context sizes, covariates, ...).
Example Arguments table:
#:GATKTable:true:1:17::; #:GATKTable:Arguments:Recalibration argument collection values used in this run Argument Value covariate null default_platform null deletions_context_size 6 force_platform null insertions_context_size 6 ...
The GATK offers native support to quantize base qualities. The GATK quantization procedure uses a statistical approach to determine the best binning system that minimizes the error introduced by amalgamating the different qualities present in the specific dataset. When running BQSRv2, a table with the base counts for each base quality is generated and a 'default' quantization table is generated. This table is a required parameter for any other tool in the GATK if you want to quantize your quality scores.
The default behavior (currently) is to use no quantization when performing on-the-fly recalibration. You can override this by using the engine argument -qq. With -qq 0 you don't quantize qualities, or -qq N you recalculate the quantization bins using N bins on the fly. Note that quantization is completely experimental now and we do not recommend using it unless you are a super advanced user.
Example Arguments table:
#:GATKTable:true:2:94:::; #:GATKTable:Quantized:Quality quantization map QualityScore Count QuantizedScore 0 252 0 1 15972 1 2 553525 2 3 2190142 9 4 5369681 9 9 83645762 9 ...
This table contains the empirical quality scores for each read group, for mismatches insertions and deletions. This is not different from the table used in the old table recalibration walker.
#:GATKTable:false:6:18:%s:%s:%.4f:%.4f:%d:%d:; #:GATKTable:RecalTable0: ReadGroup EventType EmpiricalQuality EstimatedQReported Observations Errors SRR032768 D 40.7476 45.0000 2642683174 222475 SRR032766 D 40.9072 45.0000 2630282426 213441 SRR032764 D 40.5931 45.0000 2919572148 254687 SRR032769 D 40.7448 45.0000 2850110574 240094 SRR032767 D 40.6820 45.0000 2820040026 241020 SRR032765 D 40.9034 45.0000 2441035052 198258 SRR032766 M 23.2573 23.7733 2630282426 12424434 SRR032768 M 23.0281 23.5366 2642683174 13159514 SRR032769 M 23.2608 23.6920 2850110574 13451898 SRR032764 M 23.2302 23.6039 2919572148 13877177 SRR032765 M 23.0271 23.5527 2441035052 12158144 SRR032767 M 23.1195 23.5852 2820040026 13750197 SRR032766 I 41.7198 45.0000 2630282426 177017 SRR032768 I 41.5682 45.0000 2642683174 184172 SRR032769 I 41.5828 45.0000 2850110574 197959 SRR032764 I 41.2958 45.0000 2919572148 216637 SRR032765 I 41.5546 45.0000 2441035052 170651 SRR032767 I 41.5192 45.0000 2820040026 198762
This table contains the empirical quality scores for each read group and original quality score, for mismatches insertions and deletions. This is not different from the table used in the old table recalibration walker.
#:GATKTable:false:6:274:%s:%s:%s:%.4f:%d:%d:; #:GATKTable:RecalTable1: ReadGroup QualityScore EventType EmpiricalQuality Observations Errors SRR032767 49 M 33.7794 9549 3 SRR032769 49 M 36.9975 5008 0 SRR032764 49 M 39.2490 8411 0 SRR032766 18 M 17.7397 16330200 274803 SRR032768 18 M 17.7922 17707920 294405 SRR032764 45 I 41.2958 2919572148 216637 SRR032765 6 M 6.0600 3401801 842765 SRR032769 45 I 41.5828 2850110574 197959 SRR032764 6 M 6.0751 4220451 1041946 SRR032767 45 I 41.5192 2820040026 198762 SRR032769 6 M 6.3481 5045533 1169748 SRR032768 16 M 15.7681 12427549 329283 SRR032766 16 M 15.8173 11799056 309110 SRR032764 16 M 15.9033 13017244 334343 SRR032769 16 M 15.8042 13817386 363078 ...
This table has the empirical qualities for each covariate used in the dataset. The default covariates are cycle and context. In the current implementation, context is of a fixed size (default 6). Each context and each cycle will have an entry on this table stratified by read group and original quality score.
#:GATKTable:false:8:1003738:%s:%s:%s:%s:%s:%.4f:%d:%d:; #:GATKTable:RecalTable2: ReadGroup QualityScore CovariateValue CovariateName EventType EmpiricalQuality Observations Errors SRR032767 16 TACGGA Context M 14.2139 817 30 SRR032766 16 AACGGA Context M 14.9938 1420 44 SRR032765 16 TACGGA Context M 15.5145 711 19 SRR032768 16 AACGGA Context M 15.0133 1585 49 SRR032764 16 TACGGA Context M 14.5393 710 24 SRR032766 16 GACGGA Context M 17.9746 1379 21 SRR032768 45 CACCTC Context I 40.7907 575849 47 SRR032764 45 TACCTC Context I 43.8286 507088 20 SRR032769 45 TACGGC Context D 38.7536 37525 4 SRR032768 45 GACCTC Context I 46.0724 445275 10 SRR032766 45 CACCTC Context I 41.0696 575664 44 SRR032769 45 TACCTC Context I 43.4821 490491 21 SRR032766 45 CACGGC Context D 45.1471 65424 1 SRR032768 45 GACGGC Context D 45.3980 34657 0 SRR032767 45 TACGGC Context D 42.7663 37814 1 SRR032767 16 AACGGA Context M 15.9371 1647 41 SRR032764 16 GACGGA Context M 18.2642 1273 18 SRR032769 16 CACGGA Context M 13.0801 1442 70 SRR032765 16 GACGGA Context M 15.9934 1271 31 ...
The memory requirements of the recalibrator will vary based on the type of JVM running the application and the number of read groups in the input bam file.
If the application reports 'java.lang.OutOfMemoryError: Java heap space', increase the max heap size provided to the JVM by adding ' -Xmx????m' to the jvm_args variable in RecalQual.py, where '????' is the maximum available memory on the processing computer.
I've tried recalibrating my data using a downloaded file, such as NA12878 on 454, and apply the table to any of the chromosome BAM files always fails due to hitting my memory limit. I've tried giving it as much as 15GB but that still isn't enough.
All of our big merged files for 454 are running with -Xmx16000m arguments to the JVM -- it's enough to process all of the files. 32GB might make the 454 runs a lot faster though.
I have a recalibration file calculated over the entire genome (such as for the 1000 genomes trio) but I split my file into pieces (such as by chromosome). Can the recalibration tables safely be applied to the per chromosome BAM files?
Yes they can. The original tables needed to be calculated over the whole genome but they can be applied to each piece of the data set independently.
I'm working on a genome that doesn't really have a good SNP database yet. I'm wondering if it still makes sense to run base quality score recalibration without known SNPs.
The base quality score recalibrator treats every reference mismatch as indicative of machine error. True polymorphisms are legitimate mismatches to the reference and shouldn't be counted against the quality of a base. We use a database of known polymorphisms to skip over most polymorphic sites. Unfortunately without this information the data becomes almost completely unusable since the quality of the bases will be inferred to be much much lower than it actually is as a result of the reference-mismatching SNP sites.
However, all is not lost if you are willing to experiment a bit. You can bootstrap a database of known SNPs. Here's how it works:
For users concerned about run time please note this small analysis below showing the approximate number of reads per read group that are required to achieve a given level of recalibration performance. The analysis was performed with 51 base pair Illumina reads on pilot data from the 1000 Genomes Project. Downsampling can be achieved by specifying a genome interval using the -L option. For users concerned only with recalibration accuracy please disregard this plot and continue to use all available data when generating the recalibration table.
Please be aware that if you have been using BaseRecalibrator scatter-gathered with Queue (GATK versions 2.0 and 2.1), your results may be wrong. You will need to redo the base recalibration of your data WITHOUT scatter-gathering.
This issue will be fixed in the next release (version 2.2). We apologize for any inconvenience this may cause you!


text:
Indicazioni stradali per Amber Tree Lodge Backpackers
10 Kloofnek Road, Tamboerskloof, Città del Capo, Sudafrica
Mappa & Indicazioni stradali
Cape Town City Central brings you into the Cape Town City Centre, and will drop you off at Rafiki's Restaurant and Bar.
Keep Right on sliproad to settlers way(N2).
Take EXIT 5 on left to M3/de waal Drive towards Vredehoek.
Then turn left on Rheede Street.
Turn left on Kloof Street.
Turn right on Kloof Nek road
Arrive at destination on left.
10 Kloof nek road


text:
Giving voice to children's causes
Gala honors advocates for youngsters, encourages others to join the effort
Take seven founders of Voices for Virginia's Children, a former Virginia governor, three former Virginia first ladies, a congressman, a state senator, and what have you got?
At Lewis Ginter Botanical Garden on Oct. 23, the gathering produced not only a gala celebration for the first-ever recipients of the Carol S. Fox Making Kids Count Award, but an opportunity for long-time child advocates to renew their dedication to the cause.
One such advocate, Rob Dugger, co-founded a national organization in 2006 that partners with business leaders to promote investment in early childhood development. The group, ReadyNation, has focused its efforts on collecting evidence of the economic and societal benefits of interventions in early childhood – from housing, nutrition and health care to parenting education and preschool programs.
As managing partner of Hanover Investment Group, Dugger is immersed in the world of high finance and in the task of helping asset management companies navigate shifting economic conditions.
But his real passion, Dugger noted, is uniting business leaders behind the vision of giving young children a good start in life today – with the understanding that it will pay off in a better society and stronger workforce tomorrow.
"What gets businessmen to tune into [this message] is a whole lot of people saying This is important," Dugger emphasized. "And what fires me up is what I see going on in the rest of the world.
"The rest of the world," he pointed out, "is focusing on investing in children."
Pebbles and ripples
Johanna Schuchert (pictured, far right), the individual recipient of the first Carol S. Fox award, became a champion for children's causes when she was a young mother in the 1970s.
"I learned about the issue of child abuse . . . through the Virginia Federation of Women's Clubs," Schuchert told the crowd at the gala. "I wanted to do something more."
Thirty years later, after helping to found Prevent Child Abuse Virginia (PCAV), she serves as the organization's executive director. Among PCAV's community-based prevention programs is the model program Healthy Families Virginia, which provides home visiting and parent education services to vulnerable first-time parents.
"We've all been doing this together," Schuchert told the audience in receiving her award. "Often you were the pebbles and I was the ripple, but none of us was doing this alone."
Greg Peters, president and chief executive officer of United Methodist Family Services, echoed Schuchert's theme of working together as he accepted the organizational award for UMFS.
Founded 112 years ago as an orphanage, UMFS has transformed itself into a statewide non-profit providing a variety of foster care and adoption services, treatment and education programs for troubled youth and special needs children, and family support and preservation services. In 2011, Peters told the crowd, the organization served 1100 youth and helped 344 families stay together – in addition to partnering with Fairfax County to establish Leland House.
Forging partnerships in the community, Peters emphasized, has been key to the success of UMFS. "The community is beginning to see us as something more than a service provider. . . Together we can make a difference [and do things] we can't do alone."
Like Schuchert, Peters also had praise for the efforts of the organization's supporters and staff.
"The heroes in this room," he said, "are the staff and the board of UMFS. They will do whatever it takes, and they do it because they believe in the children and the families they serve."
Not ready to learn
The Carol S. Fox award, which will be presented annually by Voices for Virginia's Children, was named for a founder and long-time board member at Voices and honors an individual and an organization that have demonstrated exemplary effort to improve the lives of Virginia's children.
At the reception, Fox took a few moments to trace her involvement with children's causes back to her days living in West Point in the 1970s, when she was inspired to establish a child development center.
"We know the most important development of the brain is in the first three years," Fox reminded the crowd. "But there was no public kindergarten [then], and some kids started school not ready to learn ... and were disruptive."
In 1987, after 25 years in West Point, Fox moved to Richmond and got involved with a similar program at the William Byrd Community Center. That led her to help found the Action Alliance for Virginia's Children and Youth (later changed to Voices for Virginia's Children), a non-partisan research and advocacy organization that serves as the Kids Count data center for Virginia.
"It's the first place Virginia legislators turn to for information ... about Virginia's most vulnerable population," said Fox.
In his welcoming remarks, Voices Executive Director John Morgan highlighted the Kids Count program as well, pointing out that Voices is known "for our bipartisan credibility and our bipartisan voice." In meetings with policy-makers, Morgan added, "sometimes we are the only group in the room that is independent. We have no stake except helping children.
"We are very proud to be the home of Virginia Kids Count. "
Recommitment and resolve
Among the Voices founders and supporters recognized in addition to Fox were former Virginia first ladies Jinx Holton, Anne Holton, and Jeannie Baliles, as well as former governor Linwood Holton. Board member Eleanor Saslaw was accompanied at the gala by her husband, Senator Dick Saslaw; and Congressman Bobby Scott received special mention for an award he earned from First Focus Campaign for Children.
It was the second consecutive year that Scott has received the national "Champion for Children" award, said Morgan – and he was the only member of the Virginia delegation to do so.
While the economic and political climate continue to pose challenges, noted one speaker in summing up, the passion in the room at Lewis Ginter Botanical Garden made it clear that those challenges could be overcome.
"Rather than get discouraged," said Greg Peters, "we've got to increase our resolve."
Quoting Mahatma Gandhi – "Be the change you wish to see in the world" – Schuchert agreed.
"No one can do everything, but everyone can do something," said Schuchert.
"I hope this gathering can be a celebration – and a recommitment to what we're doing."
Celebrating 106 years
Former Sandston resident Mildred Taylor celebrated her 106th birthday Aug. 9. Taylor, who now lives in Powhatan, is still a member of Sandston Baptist Church. She was visited the day after her birthday by several members of the church, who played for her a recording of the entire church membership singing happy birthday to her during worship. > Read more.
YMCA breaks ground for aquatic center
YMCA officials gathered last week to break ground on the new Tommy J. West Aquatic Center at the Shady Grove Family YMCA on Nuckols Road. The center, which will featured 7,600 square feet of competitive and recreational space, including water slides, play areas for children and warmer water for those with physical limitations, is the fourth phase of a $4 million expansion at the facility. West was president and CEO of Capital Interior Contractors and a founding member of the Central Virginia Region of the Virginia Chapter of Associated Builders and Contractors. > Read more.
Rotary donates to 'Bright Beginnings'
The Sandston Rotary Club recently donated $1,000 to the Sandston YMCA for its Bright Beginnings program, which helps provide children in need with school supplies for the new school year. > Read more.
Page 1 of 116 pages 1 2 3 > Last ›
Journey to mediocrity
'The Hundred-Foot Journey' fails to capitalize on tasty concept
The Hundred-Foot Journey is a curious little Romeo and Juliet of a film. A family, forced out of their native India, begins a trek across Europe.
The family's sole mode of transportation sputters and dies in a sleepy little French town, but the town's food culture is high, and that's a perfect place for a family of restaurateurs to settle down. There's only one problem – the family's rustic "Maison Mumbai" is right across the street (a hundred feet away, if the title didn't clue you in) from a prestigious French bistro with a Michelin star, run with an iron fist by the dreaded Madame Mallory (Helen Mirren, pictured).
It's here that a particular Romeo and Juliet story begins to develop, with Hassan (Manish Dayal) on the Indian side and Marguerite (Charlotte Le Bon) on the French side. > Read more.
Weekend Top 10
Enjoy the final days of summer with comedian Guy Torry, the Sam's Club National BBQ Tour or mystery writer Mary Miley Theobald at Twin Hickory Library. Another great way to welcome the beginning of fall is to check out the UR Spider Football season opener with man's best friend. For all our top picks this weekend, click here! > Read more.
Bottoms up
Short Pump brewery offers more than just beer
I am still (happily) thinking about my entire experience at Rock Bottom Restaurant and Brewery last week. Knowing nothing about this new brewery out of Denver, I was leery of brew-pub in the heart of Short Pump Town Center – this is not what I'd usually think of as a perfect fit, and yet, it was.
The restaurant and craft brewery opened in early June and features 10 beers made by female brewmaster Becky Hammond (pictured). This is the restaurant's second location in Virginia; the first is in Arlington. Behind glass walls, customers watched the beer brewing in massive steel barrels. For our up-and-coming beer region, it makes sense that Short Pump would jump on board.
As I walked up to the back of the mall near the comedy club, I was taken aback by what I saw: at the top of the stairs was an overflowing restaurant with outdoor seating, large umbrellas and dangling outdoor lights. > Read more.
Henrico County property transactions, Aug. 4-10
Fairfield, Varina meeting Sept. 8 to spotlight upcoming Civil War reenactments
Just winging it
Business in brief
Board approves Walmart, Wegmans, microbrewery
- More News
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Aug. 21, 2014Click here to read the print edition.
Journey to mediocrity
Weekend Top 10
Bottoms up
Cultural Arts Center announces 2014 fall class schedule
Restaurant watch
- More Entertainment
Obituary – Helen S. Davis
Obituary – Betty Davis Greene
Obituary – Susan Amy Hayik
- More Obituaries
Celebrating 106 years
YMCA breaks ground for aquatic center
Rotary donates to 'Bright Beginnings'
- More Community
Let's all go back to school
The death of a journalist
Henrico supervisors erred in reviving public prayer
- More Opinions
Down to the wire
Babe Ruth 13U World Series arrives in Glen Allen
RIR September race tickets go on sale May 23
- More Sports
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text:
If you had to create a school program from the ground up that best served the students and families in Alabama today, what would it be?
For one thing you would want school to be a fairly continuous process, so students would retain what they learn from week to week, month to month, year to year .
Yet to allow struggling students to get remedial help before lagging too far behind their peers we would need three or four short breaks throughout the year. Those short breaks could also allow students who excel to take enrichment classes that couldn't be taught during the regular sessions. This could give those students an extra year of education by the fifth grade.
We might want to stagger the school sessions, which would make more efficient use of your facilities and staff … no point in wasting our tax dollars.
And the school day should coincide with the parents' work day, since so many moms and dads work outside the home. Parents wouldn't have to pay someone to watch their kids during the day. No unattended children at home. Less stress on the parents.
Of course, what we're talking about is year round , extended day school.
More than 2 million students in close to 3,000 public schools in 41 states and 610 school districts attended year round schools last year..
Students in countries that routinely outscore the United States on international tests, spend more time in school, often as many as 50 days per year more than in Alabama.
In order to keep our children competitive in the world, we may have to give up a system designed for an agrarian America, in favor of one better suited for America and the world today.
12 East Delano Avenue
Montgomery, AL 36105
(334) 288-1212
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text:
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Use our Fuel cost calculator to find the approximate
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