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Funding opportunities
Pluripotent stem cells for regenerating and regulating immunity
Funding Type:
Early Translational I
Grant Number:
Funds requested:
$5 529 600
Funding Recommendations:
Not recommended
Grant approved:
Public Abstract:
It is now well accepted that the immune system, or its dysregulation, plays a central role in causing or worsening many of the most common and life-threatening diseases, such as cancer, HIV1 infection, and autoimmune disorders like diabetes. Recent research has raised the exciting possibility that cells of the immune system might be engineered to treat disease. The immune system is produced from blood-forming stem and progenitor cells (Hematopoietic Progenitor Cells/HPC) and consists of different types of lymphoid cells; of these, T cells are essential for immune-competence. In laboratory research, T cells have been engineered to kill cancer cells, become resistant to infections like HIV-1 and produce immune tolerance for autoimmune disease. In many cases, the use of adult sources of HPC or T cells (bone marrow and blood) is not optimal or even feasible. For example, HPC and T cells are absent after bone marrow transplantation and deficient after chemotherapy, they may be infected as in the case of HIV-1, or contaminated with malignant cells as in leukemia. In addition, adult HPC and T cells do not self-renew during culture and so the ability to engineer or expand them to target disease is very limited. Blood cells can be produced from pluripotent stem cells (PSC), i.e. human embryonic stem cells (hESC) and reprogrammed adult cells aka "induced pluripotent stem cells" (iPSC). Our group has shown that PSC-derived HPC can produce T cells after transplantation in mice. This finding opens up unlimited theoretical opportunities for immune cell therapy that would use banks of iPSC, perfectly matched to each patient, that can be expanded in culture indefinitely and can be engineered to produce T cells that target specific diseases, for example to treat cancer, restore the immune system after bone marrow transplantation, chemotherapy and severe infection, and produce immune tolerance to suppress autoimmune diseases and prevent organ rejection after transplantation. However, PSC-derived immune therapy cannot be brought to clinical translation because of the following bottleneck: Current methods of differentiating PSC produce a very low yield of HPC, and these HPC are inefficient at generating the cells of the immune system. In addition, the culture methods are not clinically useful as they involve the co-culture of human PSC with mouse cells. Our goal is to develop methods that can be used clinically to efficiently produce HPC that can in turn generate the cells (particularly T cells) of the immune system. This proposal brings together a multidisciplinary team of physicians and scientists with expertise in the biology of hESC, iPSC, HPC, the development of the immune system, clinical cell therapy and transplantation. These advances will have direct and immediate application for medical therapies that regenerate and regulate the immune system and open therapeutic possibilities for many serious diseases.
Statement of Benefit to California:
Development of methods for regenerative medicine using stem cells will have wide-spread applications to improve the health of millions of Californians and to provide novel, effective therapies for tens of millions of people world-wide. One major area of clinical promise involves the production of blood forming (hematopoietic) progenitors from pluripotent stem cells (PSC) to regenerate and regulate the immune system. Many severe medical conditions can be cured or improved by transplantation of blood-forming hematopoietic stem and progenitor cells (HPC), including cancer and leukemia, genetic diseases of blood cells, such as sickle cell disease and inborn errors of metabolism or of the immune system. HPC may be engineered to make them resistant to infections (e.g. HIV/AIDS) or to target specific cancers and leukemias. Additionally, transplants of HPC may induce states of immunological tolerance to provide new treatments for auto-immune diseases (e.g. Diabetes, rheumatoid arthritis, systemic lupus erythematosis) and to prevent rejection of transplanted cells or organs (e.g. kidney, liver, heart, lung). A major bottleneck to the use of PSC as a source of immune cell therapy is the low numbers of HPC that currently can be made from PSC and the relative inability of these HPC to produce the lymphocytes (T, B and NK cells) that comprise the immune system. This proposal brings together experts in the biology of stem cells, the mechanisms for development of the immune system, and the methods used to interrogate and to manipulate these cell systems. A logical series of milestones will be achieved to improve production of HPC from PSC using methods that can be used clinically and to improve the ability of HPC, in turn, to produce the immune system, These advances will have direct and immediate application for medical therapies that regenerate and regulate the immune system and will thus have wide-ranging application to the many diseases now known to be caused or worsened by immune dysregulation. All scientific findings and biomedical materials produced from our studies will be publicly available to non-profit and academic organizations in California, and any intellectual property developed by this Project will be developed under the guidelines of CIRM to benefit the people of the State of California.
Review Summary:
This is a proposal that aims to improve the ability to generate T cells from induced pluripotent stem cells (iPSCs). The investigators propose a multipronged approach to improve the T cell developmental potential of hematopoietic stem cells (HSCs) derived from embryonic stem cells (ESCs) and iPSCs. Based on the observations from their laboratory that ESC-derived hematopoietic progenitor cells (HPCs) do not efficiently undergo T cell development, the investigators hypothesize that epigenetic changes associated with the origin cell influence the potentiality of iPSC and that the use of hematopoietic cells as the source for iPSC generation will lead to improved hematopoietic potential. Successful T cell development will be essential to the success of using HPCs derived from pluripotent stem cells (PSC) for any therapeutic application, and this proposal represents an attempt to overcome this bottleneck. Reviewers were generally enthusiastic about the concept and the potential impact of the proposed research. The proposal addresses an important need, as T cell development is often poor in adults receiving hematopoietic stem cell transplantation for hematologic malignancies, resulting in a high incidence of infection. The ability to use iPSCs as a source of T cell progenitors would allow the use of autologous T cells for improving immune reconstitution, treating tumors, and potentially generating regulatory cells to treat autoimmune diseases. Enthusiasm for the proposal was dampened, however, by a lack of proposed methods that seem likely to enhance T cell lymphopoiesis above that achieved with marrow- or mobilized peripheral blood-derived HSCs. Reviewers felt that a fundamental problem of poor lymphopoiesis in cancer or autoimmune disease patients is related to thymic function, and this study is not designed to address this bottleneck. The applicant did not propose methods to generate T cells from progenitors in vitro or enhance thymic homing potential. Instead, efforts are limited to an attempt at efficiently generating hematopoietic stem cells and T cell progenitors. Without demonstration of improved T cell generation ability, the rationale for using iPSC rather than autologous adult HSCs is weak. The stated milestones are generally reasonable, but the proposed timelines are particularly aggressive. Reviewers praised the system for single cell ES determination as well designed and thought it highly probable that the system could yield compounds that promote hematopoietic differentiation. The reviewers felt that, although the second aim, generation of iPSC with optimal hematopoietic differentiation potential, is based on a scientifically intriguing hypothesis, adequate preliminary data or literature support for the proposed approach is lacking. Since iPSCs produced from the cord blood cells may contain alloreactivity, reviewers thought it would have been desirable to emphasize use of adult HSCs for reprogramming. Cell signaling and transcription network studies outlined in the proposal were considered important and well designed, but they constitute basic studies that are unlikely to have immediate impact on the translational research. Finally, the review panel believed the proposal should have devoted more consideration for the issues relating to GMP-clinical reagents and media. The PI is a leader in this field and well qualified. The research team was judged to be excellent, and the research environment judged outstanding. Reviewers, however, believed the budget to be excessive considering the proposed scope of the work. The cost of supplies was judged to be high. Another reviewer considered the number of FTEs and consultants involved in this study to be an unnecessarily high number. Finally, concern was raised over possible overlap with an existing CIRM grant. Overall, the studies could eventually have a high impact, and the proposed science is intriguing. However, reviewers were uncertain on the rationale for some of the experimental design and approaches and had concerns about the project's translational potential.


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MIDDLETON — A second mosquito taken from collection traps near the Danvers Water Treatment Plant has tested positive for West Nile virus, the town's board of health announced yesterday — and further mosquito-spraying is slated to take place on Tuesday.
The results were recently confirmed by a laboratory, according to the statement from Director of Health Derek Fullerton. A mosquito taken from the same area of Lake Street had previously tested positive for the virus earlier this month, ending a years-long string of negative test results.
The New England Massachusetts Mosquito Control Management District plans to spray a triangular swath around Middleton Pond on Aug. 27, beginning at sunset, though that depends on the weather.
Residents are urged to continue taking precautions such as using insect repellent, covering exposed skin, and avoiding being outdoors at dusk and after nightfall, when mosquitoes are most active.

subset: commoncrawl


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Victoria Business Park, Waun-Lwyd, Ebbw Vale, Gwent, Wales NP23 8AN View Map.
General Manager:
Laura Lummis.
Contact us
Tel. 01495 307185
|pub opening times
|meal times
|Monday - Thursday 11am - 11pm
Friday & Saturday 11am - 12mn
Sunday 12noon - 10.30pm
|Monday - Saturday 11.30am - 10pm
Sunday 12noon - 10pm
Whats New & Forthcoming
|See whats new and forthcoming at our Brewers Fayre.... Read more
What's New & Forthcoming
Brewers Fayre Bonus Club
Pick up a Brewers Fayre Bonus Club card next time you visit us. This will entitle you to some great savings and member only special offers.
About Us
|Victoria Park is located on a Business Park in Waun-Lwyd near Ebbw Vale... Read more
Victoria Park is located on a Business Park in Waun-Lwyd near Ebbw Vale, a rural area two minutes walk away from the railway station. Being close to a housing estate our clientele include many regular locals, passers by, visitors and business people staying at the 44 room Premier Inn. Local tourist attractions include Blaenavon Ironworks, five miles away and Brynmawr Science Visitor centre, three miles from here. There are also attractive walks to be enjoyed. This Brewers Fayre is open plan and family friendly. The bar has comfy seating and is a good place to relax and catch up with the new on the flat screen TV over a pint of the best. Together with the restaurant there are about 240 covers. Quality Brewers Fayre food is served at a reasonable price from an extensive menu and the children's menu has appetizing choices for our younger visitors. We have an indoor Playzone which is very popular with the youngsters as is our outdoor play area during the summer months. If you are in the area you must pay this proper Welsh pub a visit. We even have sheep walking around the car park!
Our Food & Menus
|We pride ourselves on offering our guests quality wholesome pub food at grea... Read more
We pride ourselves on offering our guests quality wholesome pub food at great value prices. We have a great selection of tasty dishes for you to choose from including all your pub favourites - there's something for everyone; and what's more, we've even reduced the prices of some of our most popular dishes! Our dishes on the children's menu shows our commitment to promoting healthier eating for kids. Also enjoy our weekday Carvery and all you can eat evening time buffet.
Meal Times
Monday - Saturday 11.30am - 10pm
Sunday 12noon - 10pm
Ebbw Vale Premier Inn
|Stay at the Premier Inn, situated next to this pub restaurant... Read more & Book a room
See our own website for current rates.
Available in Brewers Fayre restaurant to residents & non residents
Monday - Friday 6.30am - 10.30am
Saturday, Sunday & Bank Holidays 7am - 11am
Full Premier Breakfast from £8.25. Continental £5.25. (all you can eat).
Make a Hotel Reservation.
|Our indoor play facility has everything to keep the kids entertained.... Read more
Our indoor play facility has everything to keep the kids entertained.
Opening Times
Open during food service times.
Free of charge, adult supervision required.
Our Drinks
|We have an excellent selection of the best drinks on draught, wines & spirits... Read more
Drinks on Draught
Becks Vier, Budweiser, Carling Extra Cold, Stella Artois, Tetleys Smoothflow, Guinness & Strongbow Cider
Real Ale
Brains SA (4.2% ABV) & Brains The Rev. James (4.5% ABV)
Other Drinks
Wide Selection of Quality Wines, Teas & Costa Coffee
Our Entertainment
|Come and watch some television whilst having a meal and drink.... Read more


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Click on the image below to see a larger interactive version of the campus library map.
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FORT WORTH -- Investigators are working to determine what sparked a fire that killed a 75-year-old Fort Worth woman.
Maritta Brown was pronounced dead at a local hospital at 3:40 a.m. Rescuers found her on a couch inside her burning home at 720 East Robert Street. The fire did heavy damage to the back of the house, and the home is considered a total loss.
Neighbors reported seeing flames around 1 a.m. An off-duty police officer also saw the fire as he drove along the highway, according to one witness. She said the officer was among the first to attempt rescuing the woman, but the flames were too strong.
Emergency crews were eventually able to get Brown from the home, but she could not be resuscitated.
"It was tough last night," said neighbor Artis Purvey. "I've never seen anything like it."
Brown lived alone at the home.
"She was real nice," said neighbor Kenneth Carr. " She would come over every now and then, just to use the telephone, and then she'd go right back home."
The investigation into the fire's cause is ongoing.
E-mail firstname.lastname@example.com


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Asking about boredom is a red flag for me. Most marathon swimmers have strategies for this and don't think about too much.
I have the same problem (minus the "occasionally"), but I couldn't have expressed it so well.Occasionally I lapse into a 'sleepy' phase where my mind wanders – I lose track of 'the now' and drift off onto some thought thread – my swimming slows and gets lazy, then I 'wake up' and get back to swimming.
It's not exactly boredom I suppose, but more of a struggle to resign to spending such a long duration swimming
It looks like you're new here. If you want to get involved, click one of these buttons!


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SSI Doctoral Student Kristine Hoffman was featured recently in a news broadcast on Bangor TV stations Fox 22 and ABC 7. The story highlights Kristine's research focusing on the conservation and habitat of the blue spotted salamander (Ambystoma laterale). Kristine is looking at the breeding ecology, habitat selection and life histories of blue-spotted salamanders, including the distance they emigrate from vernal pools.
Kristine is a member on SSI's Protecting Natural Resources at the Community Scale (Vernal Pools) project.
For more information see the news article on University of Maine website.
A video of the news story is available on Fox Bangor News website.


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There's a bug in the Leave a note concept demo that manifests itself if Raccoon is installed to the memory card.
The C:\data\apache\mod_python\py\[logadd.py|logbrowse.py] scripts assume that the Apache root directory is located on the same drive as the binaries, while it actually is always located on drive C:. To fix the problem, replace
withCode:... logname = drive + "\\data\\apache\\mod_python\\py\\log.html" ... logform = drive + "\\data\\apache\\mod_python\\py\\logform.html"
in both files.Code:... logname = "C:\\data\\apache\\mod_python\\py\\log.html" ... logform = "C:\\data\\apache\\mod_python\\py\\logform.html"


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YUMS Classic Outline 9FIFTY Snapback Cap
Made of 100% Polyester, Woven
This 9FIFTY™ Snapback cap features an embroidered (raised) logo at front, a stitched New Era® flag at wearer's left side and secondary logo next to a snapback closure for an adjustable fit. Interior includes branded taping and a moisture absorbing sweatband.
- 20541785
- Color:
- Graphite/Storm Grey
International shipping available to Canada - info
no sizes available


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River's Edge Condos in Town - River View - Private Balconies in Helen
- bedrooms 1
- baths 2
- sleeps 2
- pool yes
- hot tub yes
- pets allowed no
- type Condo
- community River's Edge Condos
rates (USD)
/ week
vacation rental description
River's Edge Condos are located on the Chattahoochee River in the Blue
Ridge Mountaims of North Georgia in Alpine Helen Georgia. We are just
one block from the German Festhalle and within walking distance of
many shops and restaurants.
Your unit has a very large deck overlooking the river where you can
enjoy watching the tubers or enjoy watching the geese and deer early
in the morning or at dusk. This unit has a king size bed, woodburning
fireplace, full kitchen and two bathrooms one with a jacuzzi. It has
been completely remodeled with wood floors, granite counters in the
kitchen and baths, and very tastefully decorated.
Add the 2nd bedroom with another full bath and another fireplace with
two double beds, bring the kids or the inlaws.
property availability
- dates with deals
- unavailable dates
Last modified on 09-11-2008 at 1:09 PM.
email owner view full calendar
bavarian brook rentals 706-878-2840
condo rental amenities
Large Deck Overlooking the Chattahoochee River
King Bed
2 Double Beds
2 Baths/ 3rd with additional bedroom
Fully Equipped Kitchen
Dining Area
Living Room and Bedroom with Fireplaces
2 TV's
activities and attractions in Helen Georgia
Tubing the river
Trout Fishing
Horseback riding
Horse and buggy rides
Museums and theater
Hiking/mountain biking
White water rafting
vacation rental rates
normal-- $120 / 140 per night
holidays/oktoberfest-- $160 per night
add 2nd bedroom-- additional $85 / 130 per night
weekday and weekly rates available
bavarian brook rentals 706-878-2840
payment methods
Owner has not provided their accepted payment methods
Prior to paying a reservation deposit, always verify payment instructions by calling the phone number displayed on this listing page. By contacting the owner directly and paying by an approved method - credit card, paypal, check or bank transfer - your reservation payment will be protected up to $1,000.Learn more in our Security Center


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Daughter of murdered pensioner says attacker is "scum"
The daughter of a murdered pensioner has described the person who attacked her mother as 'scum.'
Emma Winnall who was 93, was beaten in her bed by an intruder, exactly three months ago today.
She suffered a fractured skull and a partially severed finger, she later died from her injuries in hospital.
Two people arrested in connection with her death were released without charge.
This morning her daughter joined police to re-appeal for information that might lead to the attacker being caught.


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Town Square
SPORTS: BUSC U10 Select opens season with great team play
Original post made on Aug 19, 2010
Read the full story here Web Link posted Thursday, August 19, 2010, 8:07 PM
on Aug 19, 2010 at 10:26 pm
Another great .500 showing by BUSC. Weekly, this club charges fees of close to $2k per player. This is not Rec. This should only be newsworthy when these boys, who are held out to be better than others, actually win something. Mustang 6 BUSC 1... story of their lives.
on Aug 20, 2010 at 11:36 am
Robert, you either had a kid (or kids) who didn't show any interest or talent in sports or you had your rear handed to you as a child. Regardless, you obviously don't have any clue about how this club is run or what the cost is to play in this league. You are way off on so many levels. I think the rec. league is looking for a publicity manager - you should apply.
on Aug 20, 2010 at 11:57 am
Robert, these kids work incredibly hard in this competitive club and they deserve props regardless of if they win or lose. You're the loser. Not these kids.


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Under increasing political pressure from the Bush
administration and its appointees, agency scientists find it
difficult to keep both their jobs and their integrity
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> View this now
Published on: August 02, 2011
Type of content: EGUIDE
Length: 13 pages
Price: FREE
A reliable records retention management system is a vital weapon against increased regulatory scrutiny and litigation seen more and more in IT environments today. Is your company in line with e-discovery requests? This expert E-Guide provides a crash course on everything e-discovery by outlining 10 steps to building a records retention management system and also discusses three main objectives in developing an electronic data retention policy. Read on to learn more.


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Virginia's festivals are perfect for families with funnel cakes, great music, wonderful arts and crafts, and so much more. Come, have fun!
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Doc's Guide Service
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Results 1 to 5 of 37
Thread: Roll Through Life!-THE GAME
Threaded View
May 27th, 2013 10:11 PM #63
You, Vera Antonia Fairchild and your partner Jacob Christopher 'Jake' Robinson, are getting married after three years being together. The style of your wedding is: the classic "Vegas" wedding. You honeymoon for five weeks in: New Zealand-An action-packed, thrill-seeking, adventure honeymoon. Two weeks after your return home from your honeymoon in New Zealand you find out you are pregnant! Nine months later you come home with: quadruplets, all boys! Gideon Charles, Phineas James, Lazarus Knox, and Zachary Penn are all healthy and strong.
Three days before the babies turn 3, you have another birth. This time you have: sextuplets! Alice Rose, Clara Grace, Beatrice Josephine, Hunter David, Edith Victoria, and Ryder Adam are welcomed by their big brothers.
When your oldest are 6 and your youngest are 3, you have your third and final birth. This time you have, thank the heavens, one child, a son; Ash Isaac.
One year later there is a suprise.... YOU ADOPT A DOG! It is a boy, you name it: Ozzy.
Vera Antonia Fairchild and Jacob Christopher Robinson
Gideon Charles, Phineas James, Lazarus Knox, and Zachary Penn
Alice Rose, Beatrice Josephine, Clara Grace, Edith Victoria, Hunter David, and Ryder Adam
Ash Isaac, and
OzzyJust a name-obsessed writer ever-looking for the perfect name.
Daphne | Rowena | Guinivere | Aurora | Delilah | Margaret | Aurelia | Diana | Gwendolyn | RosamundEdmund | Theodore | Joseph | Christian | Benjamin | William | Jonathan | Caspian | Gideon | Sebastian


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On Monday, March 18 a man who had been in a position of trust at PikeView High School was arrested by law enforcement officer in Mercer County.
This is a story that 59News brought to you first. Jonathan Kirk was the physical education and health teacher at PikeView High until he resigned in January of allegation of sexual misconduct with a student.
On Monday afternoon, police arrested Kirk on charges that resulted from their investigation. Those charges included three counts of Use of Obscene Matter with Intent to Seduce a Minor; three counts of Use of Minors in Filming Sexually Explicit Conduct; three counts of Distribution/Display to a Minor of Obscene Matter; tour counts of Sexual Abuse and five counts of Soliciting a Minor by Computer.
State Police said there were multiple victims all were 16 to 18-years old. 59News reported in January that more than two girls at the school made accusations against Kirk.
He is being held on a $100,000 cash only bond. Watch for more details on the story coming up on 59News at 5 and 6.


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Meet the Teams: Winter Edition
FORT MYERS, Fla. - FGCU fans will get their first opportunity to see the 2009-10 men's and women's basketball, and swimming and diving teams and coaches on Thursday, October 29 when the Athletics Department hosts "Meet the Teams: Winter Edition" at Alico Arena on the campus of FGCU.
Admission for the event is $7 and will be available for purchase only at the door. Tickets include food provided by Arizona Pizza. Doors will open at 5:15 p.m., dinner will be served by FGCU Athletics staff members beginning at 5:30p.m.
A action-packed program will follow with team introductions, a 3-point shootout, dunk contest, raffle for prizes, autographs, and scrimmages from both basketball teams.
Please reserve your space by October 27th by emailing Audrey Campbell at email@example.com.
|Copyright ©2014 FGCU Athletics. All Rights Reserved.


text:
Many baby boomers have watched their retirement savings dwindle because of unexpected events. According to a survey by Ameriprise Financial nest eggs are down an average of 117-thousand dollars.
90-percent of those surveyed, experienced at least one economic or life event that hurt their retirement savings. "Retirement derailers" include job loss, market declines and having to support an adult child.
50-to-70-year-olds with at least 100-thousand dollars in cash savings and investments participated in the survey.
(source: CNN)
Evangelist Franklin Graham prayed on a sidewalk outside the Pentagon Thursday after his invitation to a prayer service inside was withdrawn because of comments that insulted people of other religions. More>>


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Special Issue "Organic Iodine Chemistry 2012"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 August 2012)
Special Issue Editor
Guest Editor
Prof. Dr. Bimal K. Banik
President's Endowed Professor, Science & Engineering, Professor of Chemistry, The University of Texas Pan American, 1201 West University Drive, Edinburg, TX 78539, USA
E-Mail: firstname.lastname@example.com
Phone: +1 956 380 8741
Fax: +1 956 384 5006
Special Issue Information
Dear Colleagues,
In recent years, a large number of organic reactions have been reported using molecular iodine as catalyst and consequently "Organo-iodine chemistry" is considered as an emerging field of modern synthetic organic chemistry. Iodine is an inexpensive weak Lewis acid, readily available and easy-to-handle reagent for various organic transformations and yields products with outstanding selectivity and excellent yields. There is a growing trend of using iodine in organic synthesis. Molecules, a widely distributed journal of organic chemistry has planned to publish a Special Issue emphasizing "Organo-iodine chemistry". As a Guest Editor of this Special Issue it gives me immense pleasure to welcome iodine-mediated research works and reviews from academic and industrial scientists.
The main objective of this issue will be to provide useful information to researchers and students who are interested in the chemistry of iodine and its fascinating role in organic synthesis. Efforts will be made to include not only the synthesis of organic compounds but also to understand the mechanism of iodine-mediated reactions under different conditions.
I believe this Special Issue on "Organo-iodine chemistry" will offer a world-wide forum to present original research works and reviews focused on the synthesis of organic compounds especially, molecules of biological interest, using a variety of novel and eco-friendly strategies. I also hope that this issue will reflect the innovation and diversity of this growing field of "Organo-iodine chemistry".
Prof. Dr. Bimal K. Banik
Guest Editor
- iodine
- organic synthesis
- mechanism
- biologically active compounds
- catalysis
- eco-friendly reactions
Communication: Radioiodination of Aryl-Alkyl Cyclic Sulfates
Molecules 2012, 17(11), 13266-13274; doi:10.3390/molecules171113266
Received: 7 September 2012; in revised form: 24 September 2012 / Accepted: 23 October 2012 / Published: 7 November 2012Show/Hide Abstract | Cited by 1 | PDF Full-text (217 KB) | Supplementary Files
Molecules 2012, 17(11), 12718-12733; doi:10.3390/molecules171112718
Received: 11 September 2012; in revised form: 10 October 2012 / Accepted: 19 October 2012 / Published: 26 October 2012Show/Hide Abstract | Cited by 2 | PDF Full-text (754 KB) | HTML Full-text | XML Full-text | Supplementary Files
Article: Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles
Molecules 2012, 17(9), 11046-11055; doi:10.3390/molecules170911046
Received: 6 August 2012; in revised form: 29 August 2012 / Accepted: 10 September 2012 / Published: 13 September 2012Show/Hide Abstract | Cited by 3 | PDF Full-text (260 KB)
Last update: 4 March 2014


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Record Breaking Talk Submissions PyCon 2011
"PyCon 2011 has broken all existing PyCon records for content submitted by the Python community." - PyCon Blog
PyCon 2011 will be held March 9-17 at the Hyatt Regency in Atlanta, Georgia. PyCon is broken down into 3 parts: Tutorials on March 9-10, Main Conference on the 11-13 and Development Sprints to be held in the 14-17.
Having received over 250 talk and tutorial submission for PyCon 2011 the schedule for talks and tutorials are now in place and the poster section of the event has doubled in size from 17 last year to 34 this year. PyCon keynote speakers include Hilary Mason, Guido van Rossum, Rian Hunter, David Cramer, Jason Yan, Chris McAvoy, and Andy Smith. For those wishing to attend PyCon 2011 registration is now open.
What is PyCon? According to the PyCon Blog the event is presented by the Python Software Foundation and sponsored by Google and is the world's largest Python conference that brings together a diverse group of developers, enthusiasts, and organizations to explore new challenges, launch new businesses and forge new connections within the Python community.
Issue 167/2014
Buy this issue as a PDF
Tag Cloud
Tool Predicts Which Websites Will be Compromised
Carnegie Mellon researchers say 3 million pages could fall down the phishing hole in the next year.
SSH Key Management Guidelines
The US government rolls new best-practice rules for protecting SSH.
Knoppix 7.4 Released
Klaus Knopper announces the latest version of his iconic Live Linux system.
PHP Attack Puts WordPress and Drupal at Risk
All websites that use these popular CMS tools could be vulnerable to denial of service attacks if users don't install the updates.
Heartbleed Bleeds On
According to a report, many potential victims of the Heartbleed attack have patched their systems, but few have cleaned up the crime scene to protect themselves from the effects of a previous intrusion.
Drone Brain Goes Open Source
DARPA and NICTA release the code for the ultra-secure microkernel system used in aerial drones.
Password Management Services Vulnerable to Attack
Should you trust an online service to store your online passwords?
New Raspberry Pi Adds Two USB Ports
New B+ board lets you build cool things without the complication of a powered USB hub.
Microsoft Grabs No-IP.com Domains
Redmond rushes in to root out alleged malware haven.
Firefox Steps into 3D
New initiative will bring futuristic virtual reality effects to the web surfing experience.


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This beautiful calcified San Juan volcanic tuff (not limestone) crag looks like it is straight out of France. Located just past Lake City, this is THE sport climbing destination near Gunnison. The walls are steep pocketed pocketed streaked in black orange and white. The view from the crag is spectacular! Weather can be very fickle so bring a rain jacket and watch the clouds.
Getting There
Starting in Lake City, get to the road to Engineer Pass (Henson Creek road). From highway 50, turn right on 3rd street, go 2 blocks and turn left. This road turns into Henson Creek road. Set your odometer and at about 7.2 miles you will come to a pull out on you right and Gods Crag will be visible high and to the right.
Per erik rieger: watch for ticks, do your tick checks.
Climbing Season
26 Total Routes
The Classics
Browse More Classics in God's Crag
Mountain Project's determination of some of the classic, most popular, highest rated routes for God's Crag:
The Warm Up 5.9 5c 17 VI 17 HVS 5a Sport, 1 pitch, 35' High Gravity Wall
Fear is Never Boring 5.10 6b 20 VII- 19 E2 5b Sport, 2 pitches, 280' High Gravity Wall
Wishbone 5.11d 7a 24 VIII 25 E5 6a Sport, 1 pitch, 50' Creamy Salmon Wall
Bone Machine 5.12a 7a+ 25 VIII+ 25 E5 6a Sport, 1 pitch, 65' Creamy Salmon Wall
Sterling Coach 5.12b 7b 26 VIII+ 26 E5 6b Sport, 1 pitch, 65' Creamy Salmon Wall
Black Velvet 5.12b 7b 26 VIII+ 26 E5 6b Sport, 1 pitch, 65' Creamy Salmon Wall
Bone Flex 5.12b 7b 26 VIII+ 26 E5 6b Sport, 1 pitch, 65' Creamy Salmon Wall
Featured Route For God's Crag
Fear is Never Boring 5.10 6b 20 VII- 19 E2 5b CO : Gunnison : ... : High Gravity Wall
A great route with fun moves and some wild exposure! The route is mostly sustained 5.9 with a couple of 5.10 cruxes. There are three rappel stations, which allows the use of one 60m rope. The first pitch is 180 feet and can be broken up into two pitches, but it is best to climb past the first set of anchors (which is a little off route anyway). The second pitch is 80 feet and gains anchors at the top of the wall. Rappel the route, three rappels....[more] Browse More Classics in CO
Local Information for God's Crag
Latest Regional Forum Messages
From Colorado Go to Forum | What's New | Post New Topic


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Representatives for Paparazzi Accessories in WY
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St. Petersburg Mayor Bill Foster has shot down a request by the Tampa Bay Rays to explore options for a new stadium in Hillsborough County.
In a letter to Stuart Sternberg, owner of the Tampa Bay Rays, Mayor Bill Foster said that by the terms and spirit of the contract, the team cannot look for a new stadium location in Hillsborough County.
Foster said the city will only negotiate with the team for a St. Pete location or in the Gateway area, which is the site of a proposed stadium by CityScape.
In the letter, Foster writes:
"At this point, the only way to adequately preserve the interests of the people of St. Petersburg is to leave the Use, Management and Operation Agreement intact, and the City will not agree, by affirmative act or acquiescence, to any stadium exercise outside of St. Petersburg or Pinellas Gateway. However, the offer by the city to explore the CityScape proposal is still on the table, and I remain hopeful that we can work together to preapre an amendment allowing the Rays to work with CityScape to fully examine this site as a future home for the Tampa Bay Rays. While we can write letters all day long, my preference is still a face to face meeting to discuss these issues of great mutual importance."
According to Foster, the Rays are still obligated to the citizens of St. Petersburg to play either 15 more seasons or 1,215 more game in Tropicana Field. The Rays, Foster said, have an obligation to St. Pete and Pinellas County because both have stepped up to help the Rays in the past.
"When you became the principal owner of the Rays in 2005, you did so with your eyes wide open, fully aware of this history, and with full knowledge of these commitments made by your predecessors just ten years earlier. In 1995, the Dome was completely vetted by a MLB facility review team, and the city and county were asked by the Rays to step up once again to make $50 million in improvement to bring the Dome in line with Major League Baseball's standards. St. Petersburg and Pinellas County did step up, as they always have, to support the Rays."
City admin and its legal team have said letting the Rays explore locations outside of St. Petersburg opens up the opportunity for the Rays to leave the entire region.
John Wolfe, St. Pete City Attorney, said while he believes the Rays want to remain in Tampa Bay, there is a huge risk by letting them negotiate with Tampa directly.
"The Rays and the Times want us to allow them to talk to Tampa," Wolfe said at an August council meeting. "All that does, if that provision is set aside or waived, both the Times and Tampa are really helping to allow the Rays to talk to anybody in the country."
In September, the 'Rays at Carillon Park' was introduced to the public.
Developers Darryl LeClair and CityScape presented their plan for the "Rays Park at Carillon," in front of the St. Petersburg City Council, Pinellas County Commission and members of the Rays organization.
The cost could range from $424 million to $574 million, with private financing or a combination of public and private financing as options, organizers said.
"Every successful project just like this one begins with an idea," said Susan Johnson, executive vice president of CityScape, on at the Sept. 28 stadium presentation. "And that idea evolves into a vision and a vision is refined into a plan and the plan matures into a commitment … and a commitment gets a shovel."
"This moment presents the opportunity to keep the Rays in the only home they've ever known," Johnson said.


text:
Akaroa Guided Kayak SafariChristchurch, New Zealand Kayaking & CanoeingOnly 80 minuets from Christchurch, New Zealand, Akaroa Guided Kayak Safari gives you the exciting adventure you dream of! Your qualified guide will help you throughout the safari, ensuring that your comfort and safety is always his top priority....Starting at 99 Per Person
Canoe Hire And Jet Boat Tours TaumarunuiTaupo, New Zealand Kayaking & CanoeingTaumarunui Canoe Hire has Canoe, Kayak & Jet Boating on the Whanganui River. Our business is built on our ability to provide up to date equipment, give accurate information & most important deliver a Quality, Professional and Personalized service....Starting at 50 Per Trip
Adventure South New ZealandChristchurch, New Zealand Bike ToursSmall group cycling and hiking tours for all abilities with experienced, friendly guides exploring New Zealand's stunning South Island wilderness plus exciting activity based soft adventure vacations....Starting at 1,345 Per Person
New Zealand Motorcycle Tours & HireChristchurch, New Zealand Motorcycle ToursAward Winnning Service, offering fully guided & self guided motorbike tours of New Zealand. Budget to luxury accommodation. Superior motorcycle rentals at competitive prices. Our bikes consist of well maintained BMW, Triumph, Honda & Harley-Davidson....Starting at 175 Per Night
Parapro Paragliding and Paramotoring ProfessionalsChristchurch, New Zealand ParaglidingChristchurch based Paragliding and paramotoring school, providing tandem flights, tuition for paragliding, paramotoring and speed flying....Rates from 190 Per Person
Naturally New Zealand HolidaysChristchurch, New Zealand Hiking & TrekkingNew Zealand holiday & vacation planner. Experiences such as: Walk Milford, Abel Tasman, Tongariro. Sea Kayak Bay of Islands, Queen Charlotte, Milford Sound. Cycle, horse ride, raft North & South Island. B&B, wilderness, luxury, farm, winery stays....
Aqua Air AdventureAuckland, New Zealand Hang GlidingHang-gliding. Land Yachting, Hovercraft, Yike Bikes...
AJ Hackett Bungy QueenstownQueenstown, New Zealand Bungee JumpingAJ Hackett Bungy is the world pioneer of commercial Bungy Jumping. It all started in Queenstown, New Zealand in 1988, and since then they have become an established World Leader in the Tourism Industry. Bungy jumping is a must do in NZ!...Starting at 150 Per Person
New Zealand Fun Family River HolidaysRangitikei, New Zealand Rafting TripsMangaweka is the place to stop during your journey through New Zealand. Fun raft trips for all ages, riverside motor camps and other accommodation, swimming, great trout fishing, galleries, bike trails and the iconic DC3 on SH1. Next stop Mangaweka!...Starting at 75 Per Person
Nelson Hang Gliding AdventuresNelson, New Zealand Hang GlidingHang Gliding instruction and tandems...Starting at 185 Per Trip
Heli Rafting, half day to Multi day AdventuresCoastline, New Zealand Rafting TripsHeli-rafting, whitewater rafting and multiday camping/rafting expeditions across the west coast of the south island. Scenic gorges, glacial backdrops, excellent whitewater, cliff jump, canyon swims, live monster eels... Trips range from grades 2-5....Starting at $100 Per Trip
Fendalton House Bed and BreakfastChristchurch, New Zealand Bed & BreakfastsFriendly comfortable B&B with NZ born owner, superking bed and ensuite bathroom. Beautiful situation walking distance to town centre. Delicious breakfasts, Free Wi Fi...Starting at 165 Per Night
Point Break Backpackers accommodation by the beachChristchurch, New Zealand Youth HostelsEnjoy a relaxed and casual atmosphere at Point Break. The surrounding area offers everything from a relaxing day at the beach, a bathe in the sun or go shopping at local shopping mall....Starting at 27 Per Person
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Kiwi Dundee Adventures Ltd. New ZealandCoromandel, New Zealand Eco ToursDoug & Jan are two fun loving genuine 'Kiwi' Guides.Doug Johansen is regarded as one of NZ's foremost guides with a wealth of knowledge on the natural world. His feats earned him the 'Kiwi Dundee' title in 1988, the Queens medal for services to Natur...Starting at $230 Per Person
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Queenstown Wine Trail - wine tours New ZealandQueenstown, New Zealand Wine TastingFirst time tasters or wine connoisseurs join us for a full afternoon of wine tasting, just a short journey from Queenstown this relaxed personalised tour takes in a selection of our finest boutique wineries. Operating daily deparures at 12.30pm....Starting at 129 Per Person
Study English in New ZealandHamilton, New Zealand Language SchoolsStudy English in New Zealand at Waikato Institute of Education. A wide range of quality courses and programmes including General English at 6 levels (academic and general), IELTS Preparation, English for High School, Summer & holiday programmes...Starting at 340 Per Week
Rainforest, Nature Retreat, Unique accomodationBay of Plenty, New Zealand Health Spas & RetreatsIn Native Rainforest, Mount Tutu Eco-Sanctuary is Eco-Lodge, Nature Retreat/Bird Sanctuary-has 3 cosy whare/ensuite. Guests receive Glow-Worm tour, enjoy Bush Walks, feed unique Mount Tutu Sheep, & enjoy expansive woodland/water gardens. Full B/fast...Starting at 150 Per Night
Self Drive and Guided New Zealand ToursChristchurch, New Zealand Sight-Seeing ToursAt The Road Trip we offer you the chance to experience our country's unique beauty on your terms - offering flexible New Zealand guided tours and self-drive packages that give you everything you need to enjoy your time here....Great Deals Now! 799 Per Trip


text:
Radiation Oncology
Radiation Oncology
2333 Buchanan St., "B" Level
Pacific Campus
San Francisco, CA 94115
Radiation Oncology at California Pacific offers a wide range of conventional and innovative cancer treatments provided in a patient-centered, caring environment. Radiation oncology is often the first line of attack to eradicate tumor cells. At CPMC we offer the state-of-the-art treatment modalities to treat a wide variety of malignancies including Trilogy® radiotherapy with SABERKnife technology to non-invasively treating brain tumors or other critical anatomy and intraoperative radiation therapy (IORT) for treating breast cancer.
At California Pacific, we use an exacting protocol for quality confirmation with each treatment; wherein every treatment plan is meticulously reviewed before treatment starts. Daily quality assurance checks are performed on each treatment machine, and dose delivery is monitored as the treatment occurs. Each patient's treatment is planned, monitored and delivered by an experienced board-certified radiation oncologist, medical physicist, medical dosimetrist, and radiation therapist, thereby assuring safe, accurate treatment. Our staff members fulfill rigorous on-going safety training and compliance education related to the administration of radiation therapy.
California Pacific Medical Center
Bryan Hemming Cancer Care Center
Radiation Oncology
The Bryan Hemming Cancer Care Center at California Pacific Medical Center in San Francisco features some of the top-rated cancer physicians and cancer surgeons in the San Francisco Bay Area and northern California. We provide personalized patient care using the most successful cancer treatment options and procedures available. Serving communities in San Francisco, Marin and Northern California.
- Contact Cancer Patient Navigation Services.
- Visit the Cancer Services Directory.
- Learn more about the Radiation Oncology Residency Program.


text:
Just plain beautiful.
Hey guys, my first post here.... Just put this together for a buddy of mine so I thought I'd share some pics. It's a Sig P226 Stainless Elite in 9mm with a Streamlight TLR-1 light attached. The rosewood grips that came with the gun were too thick for my buddy's liking so I swapped them out with a set of factory poly grip panels. Hope you enjoy the pics!
Just plain beautiful.
I have one and they are amazing.
The black and white pic is so sick!
Great looking gun.


text:
Ask Charlotte Archive 2006-2007
Greetings, friends!
As you may have noticed, the format of the 'Ask Charlotte' archives have been changed. To the left you will see that each column has been archived with others from the same year. And, although the more historic columns (from 2006-07, for example) are still accessible--please remember that much has changed since then, and all information may not be accurate at this point in time.
If you would like to search for a particular subject amongst past columns, please use the Hartwick Web site search function (that small white box on each page).
If you have current questions for me, please complete the 'Ask Charlotte' form and send it to me!


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see you at the pole - Today's Christian Videos
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The guide to Medicare attack lines
By Becky Bowers
Published on Friday, August 24th, 2012 at 5:28 p.m.
Last updated August 27, 2012, 1:03 p.m.
A vote for Republicans or Democrats in November is a vote for politicians who plan to limit growth in Medicare spending.
Both sides agree Medicare's soaring expense must be slowed down as medical costs rise and Baby Boomers retire. Each side abuses the truth when they say the other side's method abandons seniors.
The reality is that both sides risk eroding seniors' benefits as they seek savings. But the risks aren't equivalent. If efforts to trim spending fail, Republicans are more likely than Democrats to let beneficiaries, rather than taxpayers and care providers, take the hit.
President Barack Obama's health care law reins in traditional Medicare through regulations, incentives and stronger oversight of payments to doctors and hospitals. That could limit some seniors' access to care if their doctors or hospitals can't stay afloat on reduced payments.
The Republican approach, authored by U.S. Rep. Paul Ryan of Wisconsin and embraced by presidential candidate Mitt Romney, seeks to bring more private insurance companies into Medicare. They believe market pressures will push down costs.
If that doesn't work, Ryan's plan doesn't say what it would do to meet its spending cap. That leaves it open to criticism that beneficiaries would end up paying more for their Medicare -- and maybe not be able to afford it at all.
But campaign rhetoric rarely acknowledges these complex realities. Instead, it's, "The other guy wants to end your Medicare!"
Here's a roundup to help you stay on top of the most common campaign lines.
Does either side 'end' Medicare?
Democrats have been chanting "Republicans voted to end Medicare" since an April 2011 vote on a proposed budget from Ryan, now the GOP vice presidential nominee. The claim -- often made bluntly and with no qualifiers -- was so pervasive, PolitiFact chose it as our 2011 Lie of the Year.
Ryan's most recent plan keeps Medicare intact for people 55 or older, but changes the program by providing government subsidies for people to buy either private insurance or a traditional Medicare option.
We've left it up to you to decide whether Ryan's most recent plan ends Medicare "as we know it" — a qualifier that's more opinion than checkable fact in the case of the plan's significant changes. (Read our extended analysis.)
It wasn't tough to make the call, however, when Romney declared that Obama is "ending Medicare as we know it." Under Obama's approach, Medicare would still be a large, single-payer, federally run health care program for seniors. We rated Romney's claim Pants on Fire.
Is Ryan's plan a "voucher" plan?
Democrats have repeatedly criticized Republican privatization proposals as "vouchers." Republicans don't like the word and try to avoid it. They prefer to call Ryan's Medicare plan "premium support," which evokes a history of proposals that offer a set payment for seniors to buy insurance policies with a defined set of services. Payments were designed to grow along with health care costs.
We found that Ryan's plan hovers somewhere between the two concepts — while pretty much fitting the dictionary definition of "voucher." Obama said that Romney and Ryan "want to turn Medicare into a voucher system." We rated that Mostly True.
Then there was the Obama radio ad that said Romney and Ryan would "end Medicare and replace it with a voucher." We called it Mostly False, because Ryan's plan doesn't end Medicare, and it still puts a lot of requirements on insurance companies that offer plans.
Was $700 billion "robbed" from Medicare?
Democratic and Republican plans for Medicare seek to slow Medicare's growth over a decade by more than $700 billion. An Obama staffer claimed that Ryan's plan, put forward in Congress earlier this year, included such savings. We rated that True.
But Romney went too far when he claimed that the president's plan "takes that money out of the Medicare trust fund and uses it to pay for Obamacare." That gives the impression that the law takes money that was already allocated to Medicare and funds the new health care law with it. In fact, the law uses a number of measures to try to reduce the rapid growth of future Medicare spending. Those savings are then used to offset costs created by the law -- especially coverage for the uninsured -- so that the overall law doesn't add to the deficit. We rated Romney's statement Half True.
We were even less impressed when Romney said Obama "robs" Medicare of the same amount, and gave that claim a Mostly False.
In a campaign ad, Romney pointed out that Obama attacked his 2008 opponent John McCain along similar lines. The ad accurately shows Obama saying,"Sen. McCain would pay for part of his plan by making drastic cuts in Medicare, $882 billion worth." (Back then, we rated Obama's attack False.)
Will Republican or Democratic plans hurt seniors?
Obama has said that Republicans will stick seniors with higher Medicare costs, while the Romney team says Obama's board of bureaucrats will deny them care. Ryan likes to say his plan won't affect current seniors. All of these claims stretch the truth.
Obama's been guilty of referring to an older, harsher version of Ryan's plan when he claims that it "could raise future retirees' costs more than $6,000." We simply don't have enough details to know how much extra money seniors might have to pay for traditional Medicare under the current Ryan plan, the one Romney supports. We rated the president's claim Half True.
Meanwhile, Ryan claimed that "unelected, unaccountable bureaucrats" will make decisions that will "lead to denied care for current seniors." Members of Medicare's new Independent Payment Advisory Board are appointed by the president and approved by the Senate. But the president can fire them for neglect of duty or malfeasance, and Congress can overrule their recommendations.
And "denied care" is a strong way to phrase the board's possible effect. The board oversees only a small percentage of the Medicare savings in the health care law. It's expected to recommend cutting provider payments, with an eye on getting rid of waste and inefficiency. That could restrict some seniors' access to care if some providers find they can't cope with lower reimbursements.
But the board is required by law to pay attention to issues like access to care in rural areas, and explicitly isn't allowed to engage in rationing or changing benefits. Ryan creates the specter of an unaccountable board making all of Medicare's spending decisions. That's scarcely the case. We rated his claim Mostly False.
Ryan's on somewhat stronger ground when he says that his plan for Medicare "does not affect your benefits." That's the case for his Medicare reform ideas, which would not affect people currently 55 and older.
But it ignores Republicans' promises to "repeal and replace" the federal health care law. Repealing the law would take away benefits for current enrollees — such as reducing the cost of prescription drugs, which saved Medicare beneficiaries $2.1 billion last year. Until it's clear just what benefits Republicans would "replace," we have to assume enrollees' benefits could be affected by the law's repeal. We rated Ryan's claim Half True.
See other Medicare claims you'd like us to check? Send them to email@example.com.
See individual fact-checks for complete sources.
Researchers: Angie Drobnic Holan, Louis Jacobson, Molly Moorhead, Katie Sanders
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text:
You do know that the first Portal game already was on consoles and it was exactly the same on PC, right?
It can only get better.
Don't be such a PC elitist fanboy. You made a terrible argument.
You do know that the first Portal game already was on consoles and it was exactly the same on PC, right?
It can only get better.
Don't be such a PC elitist fanboy. You made a terrible argument.
OBVIOUSLY you haven't seen gameplay versed around the single player campaign. You're probably judging Portal 2 based on the commercials being shown on TV. BTW if you were smart you would know that those bots are for THE CO-OP STORY! not the single player. get your facts right before you jump to conclusions
The portal reason is just truly bizzare. Kind of shocked that a person working for a game magazine can even make such a weird conparison and use it as evidence that the ps3/360 ports will cause the game to be "dumbed down" even though the original game was on those systems as well!
This person must just sit in their own little bubble.
Even playing Portal on Orange Box for PS3 was incredible, and Steam will definitely be getting mucho dolares for Portal 2. Valve delivers. You're just trying to get some attention, PCWorld AU. Probably because you're Australian and not American.
You do realize that the "cute" robots are only in coop right? The single player is still Chell. Some of the gameplay videos they've shown had much more complex puzzles than anything in Portal. The robots just make better 30sec commercials, thats all.
And the first one had console ports as well. While it is true that so many games that go multiplatform are often dumbed down, I just don't see that with Portal 2. Valve still has a huge audience on PC, so that market is important to them (especially because of Steam).
I doubt they would abandon their audience for a bunch of CoD kids.
I understand his argument, and it makes sense. He's going on the 'If it isn't broke, don't fix it' logic. Unfortunately, sometimes, games and other products are changed to appeal to larger crowds, even if it means losing its originality or uniqueness.
He's not saying it's definitely going to be a bad game; he's just concerned that it will turn out to be a sub-par game. So hopefully, this article is incorrect about Portal 2.
I don't think Valve has dumbed any of their sequels down. Ever. They don't have a big publisher pressing down on them. They truly seem to design games to be good and not just to sell well. And finally, they've had a solid three years to get it right.
But that's all kinda moot, isn't it? The concern here isn't about whether Portal 2 will be good, nor even if it will be as good as the original Portal. The question is whether it'll "deliver" on its massive hype. And that's the real flaw of this article: it's all just speculation, pandering to the hater crowd in the gamer community.
Valve doesn't "dumb down" their games, EVER.
Not to mention that Chell is still in single player, and the robots are only for the co-op mode.
Oh, and the first Portal had console ports.
You're clearly either an idiot, or just vying for attention, and are unfortunately succeeding.
Now this game I have heard less than amazing things about from people who've played it.
well i think they're deliberately trying to be contraversial. do us a favour and pick on a more obvious title like the next over hyped, over played and over-the-hill call of duty series. they need to take this genre to the next level before we all die of old age. :)
I agree with Duke nukem... I honestly have always thought that serious was horrible with a completely unlikable and immature character.
This I can totally agree with. MMO is always disappoint. Like DCUO, or Cataclysm.
First time hearing of this site (thx N4G for another stupid site) and clearly they dont follow the games that much butthurt pc fanboys because portal is on consoles and in SWTOR you dont craft you let your companions craft when your oflline so GG there for not following the game
First time hearing of this site (thx N4G for another stupid site) and clearly they dont follow the games that much butthurt pc fanboys because portal is on consoles and in SWTOR you dont craft you let your companions craft when your oflline so GG there for not following the game.
oh hay look i don't have to register to make a comment...
Just wanted to say this writer for PC world should have done a lot more research for the games he/she is reporting on and maybe give a opinion on some games he/she knows about not just take a game that seems like a good rant and pick and unsupported reasons a game might fail...
As for this game, I must say for the average gamer this game wont be for them as they might have not ever played a MMO in their life time... but as far as MMOs go it will be what was promised.
Also, "If only you knew the power of the DarkSide!"
This is speculative trash. If you're going to write an article of this nature, then research your subject. If you're going to down-talk a game then back it up with research and legitimate reasons why. The only two of these that I agree might be a disappointment are Duke Nukem, simply because of the bad stigma attached to it and it's dated gameplay formula (not to mention the aging of the original fanbase), and Driver, because no one was hyped for that game in the first place. And looking at your odds, I feel like you must've gotten those two right by accident. The others are solid IPs being fleshed out by exceptional developers with pedigree, and monstrous funding to back it up.
Think before you publish. Kthanx.
The Diablo 3 one is a hard one to agree with. Another game that people said this about was Starcraft 2, and that has become one of if not the best RTS games of all time, and it will single handedly save Esports. I was a lot of faith in Blizzard so I think Diablo will be fine
first time ive heard of driver: SF and i scour through games sites every single day.....so how can it be overhyped? who is writing this rubbish?
How can a game be overrated when no one knows about it?
This is sounding stupid
"Now that it's being tailored for consoles as well as PCs, and it's getting the mass-market treatment, we think Portal 2 is going to be dumbed down and cutesier than the original"
Portal 1 was on 3 platforms and Portal 2 is on... 3 platforms. Obviously a good gaming site.
And how is Driver: SF overhyped? I hadn't heard of it until now and noone is talking about it.
Why isn't an actual overhyped game on the list like Dead Island. No gameplay and it doesn't have any of the emotional punch the trailer did according to sites yet everyone's looking so forward to it.
Seriously? They should be focused on making the game not releasing information? You obviously don't know how the development of a game works, or just separation of workload. Obviously you can work on a game, while people who work for your company, like say, I don't know, MARKETING REPRESENTATIVES can release information on a game while the developers actually work on the game itself.
This entire article provides unsound arguments, which started when you compared Portal 2 (a PC game going to 360/PS3) to the Wii version of Call of Duty 3 (which didn't end up the way it was to appeal to mainstream, it did so because of hardware limitations, not to mention COD 3 wasn't even on PC).
Rockstar are not only masters of developing, they're also masters of marketing.
Remember GTA IV with the biggest marketing campaign a videogame ever had?
It was a succes and it's record sales still aren't beaten.
Don't mess with Rockstar.
They never fail.
Just like Valve.
SO F*** YOU and f***this top 5.
Holy moley these guys really do talk some **** Rockstar are the daddy of computer game makers...ask anybody in the know! L.A. Noire is going to be a very different type of gaming experience to the GTA series, we all know this. But do you honestly believe the Houser brothers(rockstar founders) are going to risk their reputation, i doubt it. These guys really do know what it takes to make a classic game...there that told you ;-)
You new to the game world? If you aren't you should know how Rockstar works, they release a few trailers showing some gameplay and some features of the game; not everything is shown, but full story details are left for the player to find out. The arguments are not unsound, you probably work for this stupid site, you're probably the retard that wrote this article.
Why is every article on n4g now a bunch of whining hipsters talking trash about anything popular? "Top reason why xbox/playstation suck" "why this game is overrated" "why i was disappointed at e3" WOW. Can we get some new online journalists that are not a bunch of whining pretentious pseudo-intellectuals?
Who is the moron responsible for this article?
your a moron mafia and la noire are two different games entirely.
Well spoken, and very good points, ...lol, i think most of you guys in here must be in your 20's or younger,lol So your perspective on the buisness of gaming and how it operates is minimal to non-existent, which is why you dont get what he's sayn, lol.
Yeah, this site is retarded.
LA Noire - JUST ANOTHER MOBSTER GAME! lol
Are you for real? Rockstar Games is publishing L.A Noire, they're not developing it. As a publisher they are marketing the game... And if you have been following news about the game you would know that it's not until recently we've begun getting news regularly...
That's because the game is nearing it's release, and It's a new concept so it needs marketing so that the game doesn't fail miserably (in sales terms).
And what do you mean "even since the games announcement"? The game was announced in 2006.... We never saw or heard anything major about the game until the latter half of last year.
Gah. Agreeing on the fact that this site and this list is an utter fail.
my mistake i didn't read your comment properly.
This list is an utter fail.
If you're looking for hits, I guess you've succeeded, meanwhile you've made your website and Australia look nonsensical and even further displaced from the real world.
- Embarrassed Australian
Rockstar has nothing to do with the Mafia games made by 2K.
Give Rockstar a chance to see what they can do.
Do you have any clue what LA Noire is about? That fact that you think it's going to belike Mafia has me thinking that you don't.
I dont know about the other games but i dont think L.A. Noire should be on that list. I mean although there's a possibility that it might be a disappointment that always exists when it comes to gaming, that game is shaping up to be something interesting.
Well Rockstar is owned by 2K so i'm guessing thats what he was getting at... Still no reason to have it on the list.
Okay, Holy smokes people!
To start, Portal2 was actually released on the PS3, Xbox 360, and PC, so you're whole argument of it now being released to the "mainstream" market is invalid. It is invalid because the original was also released to the "mainstream" market and it fared pretty well. Second, if you actually take a look at the game play, the concepts of the levels look a lot more complex than in the previous title. Plus the developers have said that the whole game will be much longer. Also they said the characters will be more developed than in the first title, so the "cutesy" aspect that you talk about is probably just new characters fully realized.
Holy mackerel, where did the call of duty 3 reference come from. First off this game will not be releasing on the Wii, second you can't compare a game that went from PC to Wii, to a game that is going from PC to PS3/Xbox 360. Just not the same argument. The problems that occur from porting from PC to Wii will be different from PC to XBOX360/PS3, so whatever problems that would hinder the game on Wii wouldn't be the same on PS3/XBOX 360 (The PS3 and 360 would also pose different problems as well, but from my knowledge not as substantial as what the Wii would encounter).
Never played Diablo so I can't comment on that one.
The Duke Nukem one didn't even make sense to me.(Maybe I'm too tired but I doubt it)
For SW who knows how old that pic is, it could be from very early in the development cycle. If you look at what recently happened with Crysis 2 on PS3, (The demo was an old build, but the final looked way better) the same situation could apply. If this is an old picture, then the improvements may not be seen. Also you cannot compare every other MMO to this one without knowing what the game play entails. You could be right, but you don't know that yet, and therefore can't put the game down for something that it hasn't done yet. Like putting a person in jail because you think they might commit a crime. On top of all that you demoralize the excited fans because they can see the potential this game offers.
The driver 4 argument is probably the most valid of the six. Although I wouldn't consider this game over hyped. I have only heard of this game once, and that was at E3, although I could be wrong about it being over advertised (that is what over hyped means by the way).
Finally I reach the one that pisses me off just as much as the portal two "argument". It's about time that a game came along and tried to change the way we look at games. L.A Noire looks to encourage us to think twice about a character, and the if we judge the truth properly, the quicker, and easier the cases will be solved.
Yet you guys seemed to overlook this HUGE detail, and deemed this to be a "guns-'n'-gangsters game" when you are actually trying to capture criminals not necessarily gangsters. Also it has a huge emphasis on detective work so its not just about the guns.
Also if you look at the track record of the developer, Team Bondi (Through Rockstar games), you find that they arebeing published by the makers of GTA, one of the best series of all time. Most of Rockstars games are in green on Metacritic, a site used to so whole heartily against the Driver series. I wonder why you chose not to include that in this article. Okay sure it's not all the same developers making the games, but the point is that most of the games published by Rockstar are in the green.
"Ever since the game's announcement, we've been bombarded with LA Noire marketing material: screenshots, trailers, concept art... it seems like every day there's something new coming out. And that worries us, to be honest — shouldn't Rockstar be concentrating on, y'know, the game itself?"
First of all the game was announced around the same time as GTA IV, around 4 years ago, with one teaser trailer. Then around three years later the next bit of information came out. It was no longer exclusive. One year later(about Dec of 2010) videos started being released showing the tech behind the game, and small amounts of gameplay. On IGN there are 10 videos and 53 pictures of the game. While battlefield 3 already has 9 videos, and it is still approximately 8 months away, while L.A Noire is a little over a month. Secondly releasing a few video's about the game a few months before the release isn't going to kill the game.
What are they supposed to do, finish the game and TELL NO ONE that it is coming out, or show them nothing and expect them to buy it based on their word alone.
And shouldn't you be excited about new stuff coming out. I mean come on, of all the reasons to hate on a game, you choose "every time we turn around something new comes out". We finally get a game that really innovates and you crap all over it.
That is my opinion on how well this article has been written. I find it appalling that whoever wrote this is probably getting paid. I've written a more thought out COMMENT, then their ARTICLE. Hey, Maybe I can have a job, and people might be satisfied with what they read.
The reasons that this person gave are 100% crap. I hope this article was a joke. I really do, because I can come up with something 800 times better in less than an hour.potential this game offers.
I'm being serious when I say I want a job, fire this goof and sign me up!
This site is dumb as hell. You play as a cop in L.A. Noire, you retards, and you solve different cases, no one knows if it's going to revolve around the mafia, but most likely it won't since you solve different cases that probably aren't interconnected. Also Rockstar is publishing, not developing. Also why would you bring Mafia 2 in it when it was developed by 2K Czech not Rockstar? I should actually write for this site and make it more credible, because it's obvious you guys don't do your homework and are only trying to make troll articles to generate hits.
I usually write long comments when I comment on an article but there is no reason to do so here I am not going to waste any time. The most important rule of journalism (at least if you want to be taken seriously) is to CHECK YOUR FACTS, absolutely everything you say completely contradicts all other information available from THOUSANDS of other sources on the internet, newspapers, and magazines. What the HELL are you talking about? Summary
Portal has been mainstream on consoles since about a year after release
SWTOR is completely different from just about any other MMO on the planet and bioware isn't known for screwing anything up
Duke Nukem I agree with I dont think its going to be awful but 15 years and multiple studios closing and the fact that gearbox isn't developing this game but "fine tuning and polishing and putting the finishing touches on it" I just dont think it will meet the hype.
LA Noire? You are an idiot I am sorry 9 out of 10 rockstar games are very good at the absolute least and this game is revolutionary in so many ways
Driver also had not heard of before this its like you wanted to be "cool" and have a top 6 list instead of a top 5 so you just threw it in there.
Diablo III
There are a lot of harsh critical things I could say of your "research" I could go the politically correct route and give positive criticism or I could simply say the nastiest rudest things possible about how you have no idea at all what the hell you are talking about? but lets just call it a day and say all of the above.
Little sidenote I and some friends have been working on our videogame review/preview website the last few months and we haven't even launched. You know why? WE ARE DOING OUR RESEARCH and we aren't going to basically troll the internet with a nonsensical story just to get "hate traffic" we are actually spending the time to do the proper research and try and be unique about how we approach it. This is pathetic I am sorry, and so you understand how bad it is for me to be saying the stuff I am to you?
I rarely ever insult anyone ever! But you are making all journalists everywhere look like tools when you post crap like this and that is not something I will condone.
Oh and your site took a good 10 minutes to load up on a high speed cable connection wtf?
Commenters and article readers!
Please do not be alarmed!
Thank you for your time!
Are you seriously suggesting just because Mafia II, (a game not even devoloped by the same company,) was mediocre that LA noire will be? By that justification I bet you thould Red Dead Redemption was going to blow because of Call Of Juarez.
And judging by the fact that GODDAMN BIOWARE is devoloping SWTOR, yes, I honestly do believe it will look as good as that screenshot. If you don't remember, Bioware devoloped Knights Of The Old Republic, which received 9.5 across the board. Don't let your own blatant bias against MMO's factor into this article.
And I'm not even going to mention Portal 2, there's been a slew of others who've already done just that.
I fully agree with this list, all of those games will probably be OK but no spectacular.
But LA Noir does have an amazing technology, i'll say that.
I notice this article says it is written by PC World staff, because the person who wrote it is probably too ashamed to name themselves, Blizzard especially have always delivered but you add to your general worthlessness by suggesting both Valve and Bioware won't get it right as well, somebody needs to stick to photocopying and making coffee.
I don't want a different game, I want Diablo. Just like SC2 I know it will be a good game, whether it'll be as amazing and new this time round I don't care. All I know is that Blizzard have never made a bad game.
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First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.
For work use, Microsoft Word and Excel programs pre-installed on the device are adequate for preparing short documents.
The Fujitsu LifeBook UH574 allowed for great mobility without being obnoxiously heavy or clunky. Its twelve hours of battery life did not disappoint.
The screen was particularly good. It is bright and visible from most angles, however heat is an issue, particularly around the Windows button on the front, and on the back where the battery housing is located.
My first impression after unboxing the Q702 is that it is a nice looking unit. Styling is somewhat minimalist but very effective. The tablet part, once detached, has a nice weight, and no buttons or switches are located in awkward or intrusive positions.


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IC Markets cTrader is an innovative ECN (Electronic Communication Network) trading platform, designed specifically with forex and metals trading in mind. cTrader combines the speed of an ECN trading platform with the multi-bank liquidity of IC Markets True ECN environment, providing clients with the ultimate trading solution. cTrader utilises proven technology that will enable you to take your trading to the next level.
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Tennessee Titans
Kamerion Wimbley - #95 - DE
|6' 4"/ 255 lbs.
|Wichita, KS
|Florida State
|Years played
|2006, 1st round, 13th pick by Browns
Report: Giants reach agreement with Bulluck
Unrestricted free-agent LB Keith Bulluck has reached an agreement with the Giants on a one-year contract, a source close to the player has told NFL.com.
Titans' Fisher upset at USC's Kiffin
Titans head coach Jeff Fisher is unhappy with new USC head coach Lane Kiffin over the manner in which Kiffin hired away Fisher's RB coach, Kennedy Pola.
AFC South training-camp reports
In the third installment in our series of training-camp reports, we look at the AFC South teams.
Reports: Titans, RB Johnson to rework deal
The Titans and RB Chris Johnson have agreed to a restructuring of his contract, ProFootballTalk.com, ESPN and NFL Network reported Monday.
Strength, quickness, instincts aid Titans' Curran
At 5-11 and 235 pounds, Titans rookie LB Rennie Curran knows he is not among the tallest players at his position, but he long ago figured out how to succeed against bigger competition.
Titans agree with LB Curran
The Titans agreed on a contract with LB Rennie Curran, a third-round pick from Georgia, the club announced Wednesday.
Titans' OL switch smooth transition
The Titans' most notable offseason shake-up on offense — the moves of Eugene Amano from left guard to center and Leroy Harris from a reserve to the starting left guard — doesn't appear to be a very big deal at all ...
Report: Titans QB Simms arrested
Titans QB Chris Simms was arrested Thursday morning in New York City on charges of operating a motor vehicle while impaired by marijuana, The New York Post reported Thursday.
Report: Titans' Morgan arrested on speeding, suspended-license charges
Titans DE Derrick Morgan, the club's first-round pick, was arrested Wednesday night in Resaca, Ga. on speeding and suspended-license charges, The (Nashville) Tennessean reported Thursday.
Titans' young DBs aim to bounce back
Second-year CBs Ryan Mouton and Jason McCourty, tested early as rookies, are competing for a starting job as the Titans' secondary looks to bounce back after a tough '09 season.
Titans agree with rookie QB Smith
The Titans have agreed on a multiyear contract with QB Rusty Smith, a sixth-round pick, the club announced Thursday.
Patience key for Titans
With two years left before QB Vince Young's contract is up, the Titans have plenty of time to decide on his future. But he's clearly their best starting option in 2010 and could be difficult to replace if ...
Titans agree with WR Mariani, DT Howard
The Titans have agreed on multiyear deals with WR Marc Mariani and DT David Howard, their seventh-round picks, the team announced Tuesday.
Titans agree with CB Verner
The Titans and CB Alterraun Verner, their fourth-round pick in the 2010 draft, have agreed on a multiyear contract, the team announced Tuesday.
Report: Titans reach deal with S Rolle
The Titans and S Myron Rolle, a sixth-round pick, have reached agreement on a four-year contract, ProFootballTalk.com reported Monday.
The Tennessee Titans have agreed to terms with defensive end Kamerion Wimbley on a multi-year deal, wasting little time after being rejected by Peyton Manning. Terms of Tuesday's deal were not announced.||||||| General manager Ruston Webster said in a statement he liked Wimbley coming out of Florida State as a defensive end in a 4-3 defense, a role Wimbley will play for the Titans. The 6-foot-4 Wimbley has 42.5 career sacks. The 13th pick overall in 2006 had 11 sacks as a rookie in Cleveland. He had 16 sacks in 32 games as a linebacker in Oakland the past two seasons before being released last week.
The Oakland Raiders have told linebacker Kamerion Wimbley they will release him one year into a $48 million, five-year deal. Agent Joe Linta said in an email Friday that he was unable to work out a new contract with general manager Reggie McKenzie so the Raiders decided to cut Wimbley instead.||||||| Oakland gave Wimbley the big contract last summer. He got paid $5 million in 2011 and is still guaranteed an additional $6.5 million from the Raiders. The team would have been on the hook for $4.5 million more in 2012 if Wimbley was on the roster Saturday, as well as an additional $13 million in guaranteed money for the rest of the deal. Wimbley had seven sacks, 21.5 quarterback knockdowns and 9.5 hurries last season, according to STATS LLC.
The Oakland Raiders have agreed to a five-year, $48 million contract with Wimbley.||||||| Wimbley had been set to play for the $11.3 million franchise tag tender before agreeing to the long-term deal Monday. Wimbley will be guaranteed $29 million in the deal, while the Raiders get additional room under the salary cap.
The Oakland Raiders have used the franchise tag to keep Wimbley under contract for 2012||||||| The Raiders originally hoped to use a $3.5 million buyback option to keep Wimbley under contract for next season. But Linta says that deal violated the NFL's rules prohibiting base salaries rising more than 30 percent in a year. That led to the Raiders decision to use the franchise tag, which is projected to be worth about $10 million. Linta says Wimbley is open to negotiating a long-term deal to stay in Oakland.
Wimbley is making sure his addition in a trade from Cleveland isn't overlooked.||||||| Wimbley had four sacks in the first half of last week's exhibition win at Chicago, overwhelming Bears starting left tackle Chris Williams with speed and moves the Raiders haven't had since Derrick Burgess' Pro Bowl years in 2005-06.


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Go Bananas for fair trade (From Harrow Times)
Get involved: send your pictures, video & news by texting Harrow Times to 80360, or upload here
Go Bananas for Harrow Borough Council's fairtrade summit
Updated 5:29pm Monday 17th February 2014 in News By Simon Stiel
Community groups and school pupils will 'go bananas' to mark fair trading and a special meeting.
People are invited to Harrow Borough Council's event, which will celebrate Harrow Central Mosque becoming the first mosque to achieve Fair Trade status.
The summit's theme will focus on making the banana trade fair, and people who attend will learn about how the Fair Trade campaign can be promoted in the borough.
Councillor Nana Asante, chairman of the Harrow Fairtrade Steering Group, said: "This is an opportunity for everyone to see how well we are doing and commit to doing their little bit to make Harrow a Fairtrade borough.
"Fairtrade is about trade justice and being part of creating a fairer world."
The event will be held at the Harrow Civic Centre, in Station Road will host the event which is on Tuesday 18 February between 6.30pm and 8.30pm.
Comments are closed on this article.