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Ginas Acoustic Stuff | 40 songs - 0% edited |
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FamilyReUnion2009 | 47 songs - 6% edited |
by Scenics Collection of Songs for the SaundersTaylor 2009 ReUnion | Beatles, Creedence Clearwater Revival, Bob Seger, John Cougar Mellencamp, , Roger Miller, Johnny Cash, Misc. Country and Western, Unknown, Tony Hazzard, written in G... |
Deramani's Songbook | 20 songs - 0% edited |
by deramani A mix of tunes for regaling the masses at Heartland and beyond. | Sting, Johnny Cash, Sister Hazel, The Who, Bon Jovi, Eric Clapton, Incubus, Felder, Henley & Frey, Gordon Lightfoot, Staind, Don McLean, Babyface and Cat Stevens |
Dr KC songbook 1 | 47 songs - 0% edited |
by Dr KC Easy songs that even an idiot like me can string together. | Pink Floyd, Unknown, Radiohead, Don McLean, Robbie Williams, Bob Dylan, Cure, Deep Blue Something, Snow Patrol, Avril Lavigne, Tom Petty, Johnny Cash, Oasis, REM... |
Cat Stevens | 7 songs - 86% edited |
by john stuart A small selection of easy to play and simply presented Cat Stevens songs, enjoy :) | Cat Stevens |
Barrett Av Songbook | 22 songs - 0% edited |
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lolly123 songbook | 97 songs - 0% edited |
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Double Espresso | 94 songs - 32% edited |
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Front Porch Favs | 69 songs - 0% edited |
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LWD'S BOOGIE BOOK | 14 songs - 0% edited |
by pioterp This is a collection of songs that have some rythm! enjoy! | Eric Clapton, Jackie Wilson, Stevie Wonder, Robert Palmer, performed by Tennessee Ernie Ford, Key: Cm, Hank Snow and Rod Stewart |
Nice mixed songs | 47 songs - 0% edited |
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Rob's Country Tunes | 70 songs - 0% edited |
by rcbrown Some good ole country songs, in other words no Rascall Flatts or Kenny Chesney!! | George Strait, Willie Nelson, Buck Owens, Hank Williams, Johnny Cash, Ray Price, Merle Haggard, Dwight Yoakam, Gary Allan, John Anderson, Moe Bandy, Randy Travis... |
SlowhandKev | 28 songs - 0% edited |
by SlowhandKev Classic Rock and Blues for parties and gigs. | Eric Clapton, Allman Brothers Band, Grand Funk Railroad, Orleans, Rolling Stones, Doors, Classics Iv, Doobie Brothers, By The Eagles, Eagles, Stevie Ray Vaughan... |
camdener songbook | 77 songs - 0% edited |
by camdener these are songs by my favourite artists that i can manage! | Kooks, Vines, Amy Macdonald, Coldplay, Suede, Nirvana, Franz Ferdinand and Strokes |
Pig Roast | 21 songs - 0% edited |
by wheatdab | Johnny Cash, Van Morrison, Everly Brothers, John Denver, Steve Miller, Pogues, Waterboys, Neil Young, Steve Earle, R. Miller, Unknown, Kris Kristofferson, Paul Simon... |
vandamonium's songbook | 120 songs - 0% edited |
by vandamonium A collection of my favorite songs | Guy Clark and Jerry Jeff Walker |
The Noize Boys | 32 songs - 0% edited |
by Steve Oliver Grand brassac | Rolling Stones, Gerry Rafferty and Buddy Guy |
A bit of everything | 95 songs - 1% edited |
by henasl | Traditional, Elvis Presley, Bob Marley, Tom Waits, Ray Charles, Jimmie Rodgers, Paul Simon, Cat Stevens, Pink Floyd, Dr. Hook, Dwight Yoakam, Band, Eric Bogle, Beatles, ... |
easy stuff | 52 songs - 0% edited |
by ruttin_juttin good fun songs that anyone can play, both acoustic and electric songs. | Lynyrd Skynyrd, Ac/Dc, Guns N'Roses, Deep Purple, Jimi Hendrix, Misc. Cartoons, Misc. Soundtrack, Alan Jackson, Black Sabbath, Misc. Blues, Kenny Chesney, Led Zeppelin... |
nuthin but fun | 79 songs - 0% edited |
by 1narvik1 Mostly simple songs that I love to play | Beatles, Elvis Costello, Kinks, Buddy Holly, Peter and Gordon, Van Morrison, Loudon Wainwright Iii, Linda Ronstadt, Creedence Clearwater Revival, Yardbirds, Ricky Nelson... |


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Funding opportunities
Stem Cell Therapy for the Lysosomal Storage Diseases, the Major Cause of Neurodegeneration in Children
Funding Type:
Disease Team Planning
Grant Number:
Funds requested:
$54 330
Funding Recommendations:
Not recommended
Grant approved:
Public Abstract:
Children with lethal inherited degenerative diseases of the brain, the lysosomal storage diseases or LSDs, should be among the first to benefit from novel approaches based on stem cell therapy (SCT). This belief is based on a number of medical and experimental observations including:
1) These diseases cause profound mental retardation or lead to death in most affected children; 2) SCT has already been shown to work in the milder forms of LSD that do not affect the brain; 3) The safety of neurotherapy for stem cell transplantation is already being established in the LSDs; 4) Many of the pertinent regulatory hurdles have already been overcome; and 5) Experimental work has clearly shown that SCT can be used to treat the brain in the severe forms of LSD.
This combination of medical and experimental data strongly suggest that the LSDs are uniquely poised to benefit from novel SCT and that this therapy is likely to be successful, a prediction that can less reliably be made for SCT applied to other brain and spinal cord diseases and injuries. Additionally, results of clinical trials of novel stem cell neurotherapies for the LSDs will be directly pertinent to proposed stem cell neurotherapies for some other neurological diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke, as specific targets for these and other brain and spinal cord diseases and injuries are better identified.
Efforts aimed at moving this new SCT into clinical practice, however, will be complex and involve basic, translational, and clinical research as well as the collaboration of multiple clinical centers. As a result, we have already recruited 20 superbly qualified clinicians and translational research scientists to work as a team in moving stem cells into clinical practice to better treat children with LSDs.
Statement of Benefit to California:
Most patients with severe diseases or injuries that might be treatable with stem cells have multiple medical problems and must be seen by multiple specialty physicians. In addition, the translation of experimental stem cell therapies to clinical practice requires the participation of basic and clinical research scientists from a variety of academic backgrounds. Thus, the Disease Team approach to these problems, supported by the California Institute for Regenerative Medicine (CIRM), is an entirely appropriate way to move stem cells from the laboratory to the patient.
Our team is focusing on a class of childhood brain diseases that causes the child's brain to degenerate and results in severe mental retardation or death. These diseases also affect other organs of the body. Many of these organs can already be successfully treated with stem cell therapy. Our team proposes to take these lessons of success and apply them to treating the brain as well. Because of this established stem cell success, this new stem cell therapy, we propose, has a high probability of success. This will not only provide a potential cure for the children that are treated with this new stem cell therapy, but will also benefit California by 1) reducing the State's burden for caring for these children and 2) providing a successful model of stem cell therapy of the brain that will both bolster public confidence in CIRM's mission to move stem cell therapies into the clinic, and lay the groundwork for using this type of therapy with other brain diseases such as Alzheimer's disease, Parkinson's disease, stroke, and multiple sclerosis.
Review Summary:
Executive Summary
This proposal targets the lysosomal storage diseases (LSDs) through stem cell (SC) therapy. The applicants make the case that enzyme replacement in the central nervous system (CNS) in these diseases has proved difficult and that neural stem cells (NSCs) or mesenchymal stem cells (MSCs) may be good candidates to supply the missing enzyme. The applicant proposes a multimodal treatment strategy, using different SC populations, perhaps in conjunction with other means of enzyme replacement and substrate reduction.
Reviewers felt that the problem being addressed in this proposal has great significance as this is a class of diseases that causes end organ destruction, severe mental retardation and/or death in children. While hematopoietic stem cell transplantation can reverse some of the peripheral manifestations of these diseases, the efficacy of reversal of neurogeneration has been limited. The effectiveness of current SC approaches for the treatment of LSDs is limited by insufficient impact on the central nervous system (CNS) and unequal efficacy in all peripheral tissues. This significantly diminishes the quality of current cures.
The applicants propose a team that will lead a clinical trial consisting of standard bone marrow SC therapy and enzyme replacement therapy, which would be augmented with combinations of systemic MSC and/or intraventicular MSC or NSC therapies. The reviewers agreed that, while the delivery method, effectiveness and safety of introducing various SC populations are established in a combination of clinical and preclinical studies, the precise SC source for the proposed clinical trial is not yet established. The applicants did not present a plan to determine which SCs should be introduced into the brain, whether differentiation of cells is a necessary component for providing functional enzyme, and whether immune tolerance protocols should be evaluated. If these questions are to be addressed in the context of the trial then a discussion is needed of how the safety and efficacy of testing multiple SC sources would be evaluated with a limited patient population.
Reviewers felt that the likelihood of clinical translation within five years is questionable due to many unknowns in this proposal, and considerable pre-clinical work is still needed before a curative strategy can be developed.
Reviewers agreed that the PI has good organizational skills and a proven ability to function as a leader of multidisciplinary teams, although the PI is not necessarily a leader in this field. The PI has assembled a large team for the proposed project. Members of the planning team that s/he has recruited bring expertise in the use of hematopoietic cells to treat LSDs, moving MSCs into clinical trials and experience in filing SC-based investigational new drug (IND) applications. While the PI's background in SCs is strong, his/her experience in leading a translational team is more limited.
The proposed plan includes the necessary personnel to execute a clinical trial of augmented SC therapy for LSDs. It also includes a detailed description of how the group will meet and work together to develop a plan, as well as how to address regulatory issues. However, it is not exactly clear how the interactions between the team members will occur. Furthermore, the plan does not provide a description for addressing the unresolved issues around SC sources to treat the CNS or importantly, how they will proceed from animal experiments to a clinical trial in humans. In summary, the reviewers did not find that the plan was sufficiently well developed at this point to recommend it for a Disease Planning Award.
Programmatic Discussion: A motion was made to recommend that this application be moved to Tier 3 – Not Recommended for Funding. Concern was expressed regarding the use of a variety of cells in the same therapeutic strategy, although the use of hematopoietic SCs was noted to be a plus. Concern was also expressed for the lack of clarity on how the applicants would transition animal experiments to a clinical trial in 5 years. These concerns were balanced by a consensus that LSDs are probably the best targets for cell therapy and the fact that the existent animal models for LSD are superb. The motion to move this application to Tier 3 failed.
Reviewer One Comments
The treatment of lysosomal storage diseases with bone marrow SC transplant is established as effective and safe. However, the effectiveness of current SC approaches is limited by insufficient impact on the central nervous system and unequal efficacy in all peripheral tissues. This significantly diminishes the quality of current cures. In this proposal a clinical trial of standard bone marrow SC therapy and enzyme replacement therapy would be augmented with combinations of systemic mesenchymal SC (MSC) and/or intraventicular mesenchymal or neural SC (NSC) therapies. The target is well established and the therapeutic concept is clear. While the potential SC sources, delivery method, effectiveness and safety are established in a combination of clinical and preclinical studies, the precise SC source for the proposed clinical trial is not yet established. Unknowns include:
• Whether peripheral MSC transplantation would be coincident or follow BMT.
• Whether MSCs or NSCs would be utilized for intraventricular implantation.
• Whether MSCs and NSCs from the same donor or from cell lines would be utilized.
• Whether immune tolerance protocols should be evaluated.
• What the longevity of transplanted cells will be in the CNS.
No experimental plan is described for resolving these issues. It is not clear whether the group feels these should be resolved prior to a clinical trial or be resolved in the context of a clinical trial. If the latter, then a discussion of how limited numbers of patients will impact on the power of a trial to distinguish between the effectiveness and safety of multiple SC sources is required. Therefore it is difficult to judge the maturity of this essential aspect of this study. This is an important clinical problem that has a very high likelihood of advancing the medical applications of SC therapies, and further defining the applications of different SC sources, provided that an appropriate research plan is in place.
Principal Investigator:
The PI is a recognized leader in human SC science and has a proven ability to function as a leader of multidisciplinary teams. The assembled team provides for the necessary expertise to plan and perform a clinical trial.
Planning Approach:
The proposed plan includes the necessary personnel to execute a clinical trial of augmented SC therapy for lysosomal storage diseases. The plan includes a detailed description of how the group will meet and work together to develop a plan and a document, as well as address regulatory issues. It does not however provide a plan for addressing the unresolved issues around SC sources to treat the central nervous system. There is no description of an experimental plan to address these issues. There is no discussion of how patient numbers will affect the number of questions that can be answered in a clinical trial setting (whether patient numbers will limit the power to discern differences between different treatment arms). Therefore, I do not believe that the plan is sufficiently well developed at this point.
Reviewer Two Comments
This is a proposal to develop SC therapy for lysosomal storage diseases (LSD). The problem is of significance, as this is a class of diseases that causes end organ destruction, severe mental retardation or death in children. While hematopoietic cell transplantation can reverse some of the peripheral manifestations of disease, the efficacy of reversal of neurogeneration has been limited. This team proposes to use SCs to treat the neurodegenerative disease in addition to the other end organs. Bone marrow transplantation is efficacious for preventing much of the peripheral pathology associated with LSDs and clinical trials underway should broaden its application to less severely affected patients. A Phase I clinical trial of human marrow SC injection into the brain parenchyma of some LSD patients is already underway, and will hopefully establish the safety of neurotherapy. MSC transplants have already been shown to be safe in LSD patients and they also have potential therapeutic benefit in tissues where BMT is not effective, such as the bones and joints. MSCs have also been safely injected into the brain of non-human primates. Enzyme replacement therapy in combination with BMT improves the efficacy of BMT, suggesting that these approaches may be synergistic. Intraventricular injection of NSCs has been efficacious in animal models of LSD and pharmacological approaches have improved efficacy. Thus, the clinical and pre-clinical data suggest that this is a mature concept that could soon be applied to patients. The concept of using hematopoietic SCs derived from the same donor as the MSCs and NSCs is a rational approach to overcoming immune barriers that may limit the survival of both NSCs and MSCs. Thus, the rationale is strong. However, there are many unknowns, such as the requirement for differentiation of injected cells in vivo, and it seems that considerable pre-clinical work is still needed before a curative strategy can be developed. Thus, the likelihood of clinical translation within five years is somewhat questionable.
Principal Investigator:
Dr. Schwartz received his Ph.D. degree at UCLA in 1992. He is a Senior Scientist II at Children's Hospital of Orange County. He has 46 publications, 10 of which he is listed as senior or first author on. He clearly has strong expertise in generating ES cell lines and has an extensive teaching track record in this area. He has led the hESC Culture Training Course and a National Human Neural SC Resource and has recruited many scientists to participate in SC workshops and symposia. He has assembled a large team for the proposed project. He leads a SC resource that provides cell lines to basic and translational research scientists in a variety of projects. Members of the planning team that he has recruited, including at least 20 faculty, have brought expertise in the use of hematopoietic cells to treat lysosomal storage disease and in moving MSCs into clinical trials. A GMP grade facility at his institution is not described, but the investigator has secured a collaboration with a clinical cell production facility for this purpose. Members of the team are experienced in successfully filing SC-based INDs. Thus, while the PI's background in SCs is very strong, his experience in leading a translational team is limited. Nevertheless, the strong group of collaborators that he has assembled should help to assure success.
Planning Approach:
A detailed planning approach, including multiple meetings of translational research scientists, medical geneticists, etc. is described. The development of the document will be performed largely by the PI with input from the team members. The team members listed include individuals with expertise in many different aspects of the treatment of LSDs. However, it is unclear who will conduct the animal research and design strategies to investigate in the animal models. This is an important issue, as the specific strategy to be evaluated clinically has not yet been determined.
Reviewer Three Comments
The LSDs while relatively uncommon are nonetheless an attractive target for SC therapy. There is some data in animal models of these diseases that SC therapy can result in normalization of enzyme levels and extend the life of the animal. Autologous mesenchymal cell transplants might be a better source of enzyme than neural SCs in respect to immune rejection of the latter which of course would be allografts. While it might be likely that combined therapies in the LSDs will be required to bring about a cure, the concept here is a long way from clinical translation.
Principal Investigator:
The PI is a senior scientist at CHOC. He has considerable practical experience with ES cells and neural SCs. He runs a successful ES cell training course, funded by the NIH. His publication record and current grant support is reasonable. He could not be regarded however as a leader in the field although I believe he has considerable organizational skills that are very important here.
Planning Approach:
The applicant has identified a broad-based group of scientists, both at CHOC and other Californian institutions. However, it is not exactly clear how he sees them interacting. He proposes to hold three meetings whereby the group will take their ideas toward filing an IND. He proposes some state-of-the-art communications to accomplish this, but there is a lack of even an outline of how they will proceed from animal experiments to humans.

subset: commoncrawl


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Harry Vonray Swayne
Position: T-DE
Height: 6-5 Weight: 290 lbs.
Born: February 2, 1965 in Philadelphia, PA
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I found this picture of a CC powered by a stationary engine in the Zagray Farm photos.
Zagray Cub CadetModerator: Team Cub
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Zagray Cub CadetI found this picture of a CC powered by a stationary engine in the Zagray Farm photos.
Bob "We don't need to think more,
we need to think differently." -Albert Einstein
Re: Zagray Cub CadetTwo seater with a rumble seat.
"The probability of life originating from accident is comparable to the probability of the unabridged dictionary resulting from an explosion in a printing shop." Edwin Conklin, biologist
Re: Zagray Cub CadetSomebody had some time on their hands... Certainly one-of-a-kind.
Re: Zagray Cub CadetHa Ha, That's ArtC's (Chester) dad. He cruises around the farm in it. He is a really great guy too.
Those Chester's are a clever and hard working bunch. 1971 Cub (Rufus) 1950 Cub (Cathy) 1965 Lo Boy Fast Hitch (Nameless III) 1970 Cub 1000 Loader & Fast Hitch (Lee)
Re: Zagray Cub CadetI like it
Explains a bit about Art now don't it Confusion breeds Discussion which breeds Knowledge which breeds Confidence which breeds Friendship
Re: Zagray Cub CadetCool.
David Dee Mock-Leonard
Nothing is foolproof to a sufficiently talented fool. Some days it's not worth chewing through the restraints
Re: Zagray Cub CadetIt was there on one of the spring startup's and it looks great in person.
I'm technically misunderstood at times i guess its been this way my whole life so why should it change now.
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I stayed for 4 nights in this hostel, really good location near Termini. The hostel itself is small but it has 3 bathrooms and like 4 rooms, so you really feel like you are sharing flat with other girls. The kitchen is small but it has the necessary like fridges and microwave. The only thing missing is cuttlery!! please get... More
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Mabelynn Capeluj
Hometown: San Diego
Height: 5' 8"
Age: 22
Mabelynn Capeluj was born and raised in sunny San Diego. She is currently studying broadcast journalism at Chapman University. After she obtains her Master's degree, Mabelynn aspires to work for E! News as an Entertainment Reporter. Aside from being a student, Mabelynn is a working model and has shot campaigns for several widely recognized brands.
Recently, she was named a spokesperson for the National Psoriasis Foundation and is the Ambassador for the Walk to Cure Psoriasis in Los Angeles and San Francisco. She was diagnosed with this chronic autoimmune disease that appears on the skin at the age of sixteen and is proud to raise awareness and funds for this great cause.
In her spare time, she likes to go to the beach and enjoys outdoor activities such as jet skiing and rock climbing with her friends. She is proud of being a big sister to her six younger brothers. True to her Latin heritage, Mabelynn loves to spend time watching soccer games with her family.
In her own words
fun facts
- 1
There is never a dull moment in Mabelynn's life since she is the older sister to six younger brothers.
- 2
Mabelynn was diagnosed with psoriasis at age 16 and is now a spokesperson for the National Psoriasis Foundation.
- 3
Mabelynn modeled for Miami Swim and recently did a Sketchers campaign.


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Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)
Tracking Information | |
First Received Date ICMJE | May 26, 2011 |
Last Updated Date | February 27, 2014 |
Start Date ICMJE | October 2010 |
Primary Completion Date | January 2014 (final data collection date for primary outcome measure) |
Current Primary Outcome Measures ICMJE |
Fatigue severity scale [ Time Frame: Baseline, 3 M, 6M, 9M,12 M ] [ Designated as safety issue: No ] Self reported fatigue severity scale, (agreement with 9 questions describing impact of fatigue on daily activities) |
Original Primary Outcome Measures ICMJE |
Average walking speed [ Time Frame: Baseline, 12 M ] [ Designated as safety issue: No ] Average walking speed calculated from 25 foot walk. Distance (feet)walked divided by time in seconds. |
Change History | Complete list of historical versions of study NCT01381354 on ClinicalTrials.gov Archive Site |
Current Secondary Outcome Measures ICMJE |
Original Secondary Outcome Measures ICMJE |
Current Other Outcome Measures ICMJE | Not Provided |
Original Other Outcome Measures ICMJE | Not Provided |
Descriptive Information | |
Brief Title ICMJE | Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS) |
Official Title ICMJE | Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS) |
Brief Summary | The study will use a multimodal therapeutic lifestyle intervention consisting of a study diet, stressing more vegetables and fruit, elimination of foods at greatest risk for food allergy, meditation, self massage, progressive exercise and neuromuscular electrical stimulation for rehabilitation of gait and fatigue disability in the setting of secondary and primary progressive multiple sclerosis with gait disability. |
Detailed Description | Restoration of function is very rare in individuals with MS who have experienced gradual worsening in the absence of acute MS symptoms (relapses) and partial or complete recovery of those acute symptoms (remissions). A recent case report of a patient with secondary progressive MS documented a transition from scooter dependence to mild gait disability following the initiation of electrotherapy in the form of neuromuscular electrical stimulation and nutritional interventions aimed increasing the nutrient density and decreasing the risk of food sensitivity and food allergies. Multiple studies of neuromuscular electrical stimulation in athletes, cerebral palsy and stroke patients have demonstrated gains in strength and coordination. Multiple authors have reported that antioxidants, essential amino acids and micronutrient rich diets are neuroprotective. It is likely that the combination of the intensive nutrition and the electrotherapy contributed to the marked gains in improvement. However in the absence of an additional case report the strength of the association remains unknown. The intent of this study is to replicate the interventions from the case report as closely as possible. Our primary objective is to measure how many and how completely subjects implement 1) the nutritional interventions, 2) the home exercise program intervention, and 3) the electrotherapy intervention and if the improve improved nutrition and exercise are associated with improved function. To assess improvements in function will measure 1) the change in nutritional status as reported in food frequency surveys, 24 hr dietary recalls, 2) change in neurocognitive testing and behaviors, 3) change in self-reported function and disability scales, 4) change in gait and 5) change in medications doses or classes for MS related symptoms. Subjects will be followed for three years. After the first year, subjects will not receive intensive support from the study team. The subjects return at months 18, 24 and 36 to assess adherence with study interventions, function and quality of life. Nutrition intake is assessed again at 24 and 36 months. To assess for safety we will assess safety labs (kidney and liver function tests) and changes in weight, and self reported side effects questionnaire. |
Study Type ICMJE | Interventional |
Study Phase | Phase 1 |
Study Design ICMJE | Endpoint Classification: Safety Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Condition ICMJE | Multiple Sclerosis |
Intervention ICMJE |
Study Arm (s) | Experimental: Combined intervention
Combination intervention consisting of the following: structured modified paleolithic diet, Progressive Exercise, Neuromuscular Electrical Stimulation designed to facilitate the adoption of multiple therapeutic lifestyle behaviors associated with superior health outcomes.
Publications * |
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
Recruitment Information | |
Recruitment Status ICMJE | Active, not recruiting |
Estimated Enrollment ICMJE | 40 |
Estimated Completion Date | May 2016 |
Primary Completion Date | January 2014 (final data collection date for primary outcome measure) |
Eligibility Criteria ICMJE | Inclusion Criteria:
Exclusion Criteria:
Gender | Both |
Ages | 18 Years to 65 Years |
Accepts Healthy Volunteers | No |
Contacts ICMJE | Contact information is only displayed when the study is recruiting subjects |
Location Countries ICMJE | United States |
Administrative Information | |
NCT Number ICMJE | NCT01381354 |
Other Study ID Numbers ICMJE | 200911781 |
Has Data Monitoring Committee | Yes |
Responsible Party | University of Iowa |
Study Sponsor ICMJE | University of Iowa |
Collaborators ICMJE |
Investigators ICMJE | Not Provided |
Information Provided By | University of Iowa |
Verification Date | February 2014 |
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |


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Vanity Stool Bench by Coaster
This upholstered cherry vanity stool offers a tasteful solution to your miscellaneous storage and seating needs. Lifted on four shapely legs, this piece emanates a sense of movement that is sure to draw the eyes and add dimension to any room. A rich cherry finish on the leg and base woodwork creates a comforting warmth, while a floral and leaf upholstered pattern on the seat provides a traditional touch of elegance to refine the piece. To top it off is a lift top seat that offers ample storage space for discreetly tucking away items with ease. Place in a hallway or beside a wall to add a classic piece to polish any room.
- Traditional Style
- Floral Fabric Upholstered
- Wood Veneers and Solids Construction
- Lift Top
- Ample Storage Space
- Cherry Finish
- Minor Assembly Required
- Overall Size: 15"W x 21"D x 18"H
- 13.2 Lbs.
- Classic,
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Now You Can Get That 'Whee, I'm Popping Edamame!' Feeling Wherever You Go
Love edamame? Have no idea what edamame is? They're soybean pods. And the beans inside are delicious. Mmmm, soybeans, mmmm. Half the fun of eating them is kicking the scrumptious little bastards out of their pod home. Pop! Now you can get that feeling anywhere thanks to Bandai's Puni Puni Edamame keychain. The $6 gadget gives you that satisfaction of evicting soybeans whenever you want. Each bean has a different face on it, so you'll never get bored because each pod will contain three different faces! That's a lot of entertainment. For six dollars. Also, it says you're not supposed to eat them but I did anyways. I'm growing a bean plant in my tummy!
Hit the jump for a disturbing promotional picture featuring a guy with streamers coming out of his eyes, and two videos. Of which you should at least watch the first, so you can see all the fun to be had.
Thanks to Mike, who knows the only good beans are magic ones. Jack and the beanstalk these, bitches!
Mmmm, bento boxes. They combine two of my favorite things. Bento. And boxes. Apparently Anna the red makes these delicious lunches for her boyfriend, who might very well be the luckiest guy in the world. You don't want to lose this one, boyfriend-guy. Hold on tight, man. ... / Continue →
I don't get it: I love bacon, and I love boobs, but something about this image made me want to hide under the bed and weep into my Pokemon blanket. Hit the jump for the uncensored version, which may or may not be suitable for work depending on your employer's policy on delicio... / Continue →
That's right folks: according to the cannibals of Papua New Guinea, the Japanese are delicious. Anthropologist Olga Ammann describes it more succinctly in the book. She quotes people who have eaten other humans: "The meat of white people smells too strongly and is too salty.... / Continue →


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Whether a beginner or an expert orchid grower, you will find membership in the American Orchid Society a truly rewarding experience. You'll join over 16,000 others worldwide who share a passion for orchids, as well as furthering conservation and research efforts for these wondrous plants. Join the AOS now Click here
Katie is an amateur photographer who over the years as a mother, early childhood educator, and an avid indoor/outdoor gardener has taken numerous pictures of children and plants. As a student in the orchid judging program, Katie discovered educational benefits from studying the multiple views of her enlarged orchid photos on a computer screen. This intensified her desire to take the clearest most detailed photographs of orchids possible. Katie is continuing this pursuit as the current AOS awards photographer for the Great Lakes Judging Center. She also enjoys doing the SITF (Species Identification Task Force) measurements and photos for provisional awards requiring identification. The smaller the flower and flower parts the more she enjoys the challenge.


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Request your free information packet now!
Learn More- Events
- Dordt College News
Dordt College News
Dordt Pair Earn Honors
November 12, 2012
(Monday, November 12; Sioux Center, Iowa) Meghan Warners (Senior; Hudsonville, Michigan) and Heidi Ferkranus (Sophomore; Thousand Oaks, California) earned honors in balloting done by the conference coaches at the conclusion of the 2012 women's soccer season.
Warners made the all-GPAC second team as a defender and scored two goals for Dordt this season. Ferkranus started and played in 16 games this season for the Defenders.
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RuBot II – The Rubik's Cube Solving Robot
At speedcubing.com I read about a new version of a robot called RuBot II which solves Rubik's Cube. Solving Rubik's Cube is one thing, but building a real looking robot solving Rubik's Cube is really something else.
RuBot II has been built by Pete Redmond from Dublin in Ireland. It has to be the coolest looking robot solver ever with sound and music. There are cameras in the eyes of the head that scan the cube before the pneumatic arms solve it. It usually solves the Cube in a max of about 50 seconds (not including [Read More...]


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I went to high school with Jennifer Aniston. This was long before Friends made her a superstar, and Aniston was just another slightly awkward teen at the High School of Performing Arts/LaGuardia School of the Arts. You may know it as the Fame school, where adolescents danced in the cafeteria and lea ... More >>
With 22 Olympic medals (18 of them gold), Michael Phelps is the most decorated Olympian in history. Though he's obviously a champion swimmer there's another sport Phelps excels at without even trying - competitive eating (if it's on ESPN, it's gotta be a sport, right)?Though Phelps hasn't yet compet ... More >>
Jamie Oliver's Food Revolution continues with its third episode. This one was jam-packed! It included Jamie's food quizzes for students (See above and tell me the guacamole Q&A isn't a l'il bit funny). But seriously, a lot going on in this episode. It starts with Jamie's culinary class at West ... More >>
Judd Apatow delivers
Crist and a former beauty queen are "a confirmed item" at least in some newspapers


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Annapolis Office of the President
"The Republic of St. John's College"
Convocation Remarks of Christopher B. Nelson
President of St. John's College, Annapolis
August 27, 2008
Welcome to St. John's College. A warm welcome to our entering freshmen and their families and friends! Welcome back to our returning students, faculty and staff!
I want to tell you a story which opened up a question for me that I simply could not resist exploring in preparing these remarks.
In the spring of 2004, a friend of mine, the president of another liberal arts college, called to ask for a favor. He was being given a six month sabbatical and wondered whether he might enroll at St. John's College or take some classes with us over the fall term. We talked some about the importance of beginning at the beginning, and he got excited about reading Homer, Plato, Herodotus, Thucydides, Aeschylus and Sophocles with our freshmen. He ended up auditing the fall freshman seminar, reading everything expected of him, and remaining a silent participant in the conversation. You can read all about his sabbatical experience in a newly published book entitled Racing Odysseus, chronicling his experience in the classroom, on the quad, in the coffee shop, and especially at the boathouse, where he resolved to join the novice crew and take up rowing on the Severn River in the wee hours of each morning with a good sized group of eager, if sleepy, students. It turns out that the star of the story is our very own Mr. Pickens, Director of Athletics at the College, but several students and tutors play lead support roles in the education of my friend, "Rusty" Martin.
After he'd been at the college a while, and become acquainted with many of our students, mostly freshman, he found himself observing out loud to one of his crew mates as follows:
"Like you, Tom, so many of the freshmen I have met applied only to St. John's. They seem to have a real sense of what it means to be a Johnnie even before they get here." (Does this sound familiar to any of you?)
"Maybe so," Tom responds ... "But they aren't Johnnies when they arrive."
"So when does that happen?" I ask, surprised by his response.
"When they have completed Plato's Republic! Then they become Johnnies."
End of story. But I was now hooked on thinking through what I'd just read. What would it mean to say that one becomes a member of this college community upon completing the six seminars we devote to Plato's Republic in the middle of the freshman fall term? (In fact, freshmen will be halfway through it at Parents' weekend, and you parents can return to campus to test the theory and ask your students this question.)
I have no idea whether this view of Mr. Tom's is widely shared at the college, but I thought it was worth taking seriously. So, I'd like to play with the idea for just a bit. I recognize that I can only begin to tease out a few possible answers with a book as inexhaustible as the Republic. But here's a start.
If there is a principal question at the root of the many that are explored in the Republic, it may be "What good is justice? Should we choose to live the just life or the unjust, and why?" Indeed, the dialogue opens with a spirited argument for the good of injustice but closes with a myth that reminds the readers of the thousand years of punishment that awaits the man who chooses a life of injustice over one devoted to justice. The dialogue is Plato's longest, and engages more participants than is usual. The two principal interlocutors, however, are the young Glaucon and Adeimantus, brothers to Plato himself, who does not appear as a character in the drama.
These two young people, particularly Glaucon, behave a lot like St. Johnnies. They pursue Socrates; they pursue conversation to get to the bottom of things they can hardly fathom; Glaucon at least just won't let up; he questions everything at each turn. Socrates quickly sees that he must take Glaucon seriously because Glaucon has both passion and ambition. He can see the good in Glaucon's soul, in his desire for understanding, but he can also see the dangers to both Glaucon and the state if a mind as fertile as Glaucon's is not turned to the good and is instead allowed to play with false icons. Glaucon needs to be persuaded that it is better to do right than wrong, and he needs to own the argument himself; it must be a case that he will not forget, filled with images, arguments and stories that will not fail to keep him straight. Socrates has his work cut out for him, and he puts together as beautiful a set of images and arguments as we can find in all literature.
Of course, to ask the question "What good is justice?" provokes the next: "What then is justice?" To help answer the question, Socrates and his two young helpers set about to found a city in speech which is designed to help us see what justice might look like on a large scale, in order that we might better understand what justice would look like in the human soul. It turns out that this city is not populated by people that Glaucon can either recognize or respect. He calls it a city of pigs, one that satisfies the appetite of the stomach, but not of the chest or the head. There is no place in this city to practice leisure, enjoy the finer arts, or move beyond a life of consumption to a life more noble. They reorganize the city at least twice more, but each of these cities seems to fail another of Glaucon's tests that they be realizable in our political world.
So, Socrates seeks to answer this demand with one of his more memorable statements, in the dead center of the book: "Unless the philosophers rule as kings, (he says) ... there will be no rest from ills for the cities, ... nor I think for human kind, nor will the regime we have now described in speech ever come forth from nature, insofar as possible, and see the light of the sun." We can only suppose that if the earlier versions of the city were unrealistic, this latter suggestion — that the best king must also be a philosopher, a lover of wisdom — would be still further beyond the bounds of imagination for Socrates' interlocutors. To their credit, Glaucon and Adeimantus push him on to justify his claim. Socrates agrees, and goes on to give an account of the life of the philosopher and the education appropriate to him.
In the middle of this explanation, Socrates gives us three of the most memorable images our students will encounter in their four years at the college. First, he compares the Good, which is the object of the philosopher's search, to the Sun which is the source of life, of all that is, but also the illuminator of all the appearances in the world. Socrates cannot seem to say what the Good is, but he can give us a sense of what it is like.
Second, he proposes a geometric model, a "divided line" to give us a picture of what the ascent to the Good might require of us mortals still in this world below, a sense of the kind of intellectual activity we must engage in, the kind of journey we must take to get closer to that object beyond us. In the study of mathematics, we quickly come to understand that the pictures we draw of squares and triangles, lines and proportions, are just images or representations of the true objects of geometry, which are only accessible by thought. Through the image of the divided line, we come to appreciate the need to access a world of intelligible objects in order to better understand what lies behind, and gives order to, their appearances in the visible world.
Third, in the cave analogy, Socrates gives us a drama to describe the great difficulty and pain we can expect in making the ascent from the world of images to the one source of all we can see and know. He asks us to imagine that we are all prisoners in a cave, chained so that all we can see are the shadows cast upon a wall in front of us. We cannot, on our own, turn around and see that these shadows are not real at all, but mere reflections of objects carried by people behind us who are passing in front of a fire which is the source of the light that casts the shadows. He describes first the pain, then the disbelief, and finally the wonder experienced by a prisoner who is released from his bonds and forced to turn around and look into the light of the fire and see what the image makers have known all along.
But that is not all. This cave has an entrance open to the light of the sun across the whole width of the cave. Socrates now asks us to imagine that the newly released prisoner is dragged up the steep, rocky, upward way out into the light of the sun. At first, he'd be blinded and see less well than before, but then he would get accustomed to the light and see all the other things the world has to show him — the waters and the land and the starry heavens above, until he could make out the sun itself and see what it is like. That man would be happy at his freedom from the shadows below, and would pity those still in the cave. His education would have literally been an education in the art of turning around, the art of seeing better, in a truer light, what is already really there, of seeing what ought to be seen.
Around here, we sometimes call this an education in the arts of freedom, or the liberal arts — the arts that liberate us to flee the bonds of prejudice, the false opinions, and the shadows about us, and see things as they truly are. Every image, every opinion expressed by the image makers and spin doctors around us, should be an occasion for us to pull ourselves, and others with us, out of our caves and into the light of the sun. We recognize that this sun is there for everyone in the cave to access. The entrance to the cave is open to all who are below.
After exploring these images, Socrates then constructs the education of the philosopher, and explores the kinds of governments that arise when the rulers are no longer philosophers. He closes with a grand overarching myth that attempts to incorporate the whole, reminding us that we have a lot at stake in the choices we make in living our lives. Just as we are meant to see the city-building exercise that occurs in the first nine books of the Republic as an image of the education of the individual soul, so we see the closing myth as an image of the choices available to that soul. We see that it is literally a matter of life or death (or at least a matter of great reward or unimaginable punishment) how we choose to live our lives, and how wise we would be to turn ourselves now to the question of justice so that we might learn to live a life that practices it. The well regulated soul, one that is turned to the Good, that is whole, well integrated and balanced, is also, we imagine, the soul best fit to rule our city.
I think it is time for me now to try to give my answer to the question I opened with: What would it mean to say that our students don't become Johnnies until they've finished the Republic?
The dialogue probably gives us the best account we have of what learning ought to be. It belongs to us at the college, and serves as a kind of model for our program of instruction. The book thus gives our students an opportunity to examine the education they are then engaged in, allows them to ask what it would be like to construct a curriculum fit for a philosopher king, and invites them to compare it to the one they are undertaking at St. John's.
The Republic is a beautiful book, filled with the richest of images that help us remember that the difficult search for truth is worth all the effort. It gives us poetic, musical and mathematical images, myths and analogies, to aid us in our search for an understanding of our world and our place in it, images we cannot possibly forget, images that will be available to us forever.
Like all of Plato's dialogues, the Republic engages the readers and asks them to become participants in the dialogue that Socrates is having with his friends. It asks us to question the answers given by Glaucon and others, to try them out and formulate better ones. It also helps to lead us up out of our own personal caves, encouraging us, and showing us how to find our way to a life that is better than we have experienced heretofore.
The Republic allows our freshmen to see how integrated the whole of learning is in relation to the singular soul. It helps explain the importance of mathematics in our curriculum, that it is not just a tool required for the specialist in the sciences, engineering, or the trades, but is an indispensable aid to philosophy itself, an aid to self understanding.
More than anything, however, I think it must be in our several seminars on the Republic that we become aware of the republic that is shaping itself around us, the republic of friends around the table who are searching together for answers to the deepest of questions: how we ought to be living our lives. We, like Glaucon and Adeimantus, find ourselves being initiated into the one republic that Socrates and his friends have succeeded in realizing. At St. John's, we call this republic our community of learning.
In the world, we often speak of the ties that "bind" us to a human community as healthy things, often beautiful and reaffirming ties. It is easy to forget the dark side of this image which is that we can be "tied" and "bound" to a community as to a cave that we fear to escape. We can become yoked to a larger political body by a common interest, a piece of territory, a tribal custom, a shared enemy, or a popular idea — foundations that we may cease to question. And questioning these foundations of community can become taboo, as the chains tighten about us.
We are fortunate, then, that the larger community most of us belong to, the United States of America, is founded on a paradox: the ties that bind us as Americans are rooted in human freedom, and the more we exercise the freedom to question our institutions the stronger are our ties to the founding principal. That freedom, protected by our laws, provides us with a very comfortable and open cave in which to live our lives and shape our institutions.
We at St John's have taken advantage of that freedom and that cave to found a college grounded in a very similar paradox: we find our truest sense of community in an image of human freedom that finds us somehow "together" seeking to escape the confines of the individual caves that imprison each of us. For lovers of wisdom, the young Glaucons among us, the desire to see things as they are, to strive toward the source of our being and come in to the light of the sun, is too beautiful an activity to resist — and too wonderful not to share with others. We make this search for truth, this struggle to climb out of our caves, our chief community endeavor.
Perhaps, in our search for such a liberating community, and in our occasionally achieving it, "then, we become Johnnies". Nonetheless, I will today welcome you to the Republic of St. John's College. I'm done trying to justify why you must wait 10 weeks to become one of us. We are happy to call you ours today, and to welcome you to our community of learning.
Thank You.
I declare the College in session this 27th day of August, 2008.


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Buy your favourite cutaways and archive images online now. Thousands of unique aviation photographs available
A demonstration to the press and officials of the technique in which the segmented fuselage of a Supermarine Spitfire could be loaded into Avro York C.1, MW105 14th January 1944.
Same comment as for image/page #333 - I don't think this is from a Spitfire. (York? Lanc. ?)


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Growth & Planning
Writers on the Range
One species versus 1.8 million others
Susan Tweit sees the growing tally of roadkill as a sign that there are too many humans threatening ecological balance.
by Susan Tweit, Sep 29, 2008 -
Keep 'em down on the farm
by Richard van Pelt, Sep 09, 2008 -
Wet dreams
by Ramona Gault, Sep 09, 2008 -
Don't eat the rich, tax them
by David Graber, Sep 09, 2008 -
Book Reviews
Portrait of a threatened land
In Travels in the Greater Yellowstone, Jack Turner celebrates and fights for the preservation of an incredible but endangered landscape.
by Matt Goodlett, Sep 01, 2008 -
Peace on the Gila, too?
by Estevan Lopez, Aug 26, 2008 -
Death, and taxes
In Western communities with runaway land values, many ranching heirs have a hard time holding on to the family farm.
by Jennie Lay, Aug 15, 2008 -
Winning the West
Primer 6: Immigration
Our policies are schizophrenic.
by Jonathan Thompson, Jul 05, 2008 -
Regulating the river
Montana counties set streamside setbacks
by Andrea Appleton, Jul 03, 2008 -
Plowing under the fields of shame
Rebecca Clarren talks to migrant farmworker women about a threat they face every day in the fields: sexual harassment and assault by coworkers and bosses.
by Rebecca Clarren, Apr 14, 2008 -
The leasing protest game
Conservationists can file formal protests when the BLM wants to auction off public land to energy companies, but the differences between regional management plans and styles make the protest game little more than a crapshoot.
by April Reese, Apr 14, 2008 -
Yellowstone grazing allotments
Buyouts and tradeoffs
by Francisco Tharp, Mar 21, 2008 -
Two Weeks in the West
Two weeks in the West
A flurry of end-of-year easements saves lots of lovely landscapes; heli-skiing wins in Utah; snow-lovers help starving Colorado deer; a possible ceasefire on the Klamath; and bark beetles are destroying Colorado's lodgepole pines.
by Jodi Peterson, Feb 04, 2008 -
Writers on the Range
Whatever we do about illegal immigration, somebody suffers
Philip Cafaro takes a thoughtful look at the impacts of illegal immigration on Colorado's construction trade.
by Philip Cafaro, Jan 28, 2008 -
Writers on the Range
A bad idea hits the gas pumps
Dustin Heron Urban resolves never to put ethanol-spiked gasoline into his Prius again.
by Dustin Heron Urban, Jan 21, 2008


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Converse 2 Tone Mens Baseball JacketConverse offer a varsity jacket that captures all of the cool and creative style that's made the brand such a recognisable name around the world. This baseball jacket is designed using a two-tone colourway that draws the eye and makes sporty style easily achievable. Signature branding comes in the form of a Chuck Taylor logo to the chest, while the elasticated hem and cuffs round off the piece with a compact, neat fit. Wear this baseball jacket over a Converse T-shirt, and pair it with jeans and Chuck Taylor All Stars for a taste of preppy Collegiate Americana. Useful info:
View all Converse products | |


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In 1816, James Hart Stark and a small band of pioneers moved from Kentucky and settled on the western banks of the Mississippi in a place that would later become Louisiana, Missouri. With him, Stark brought a bundle of apple scions from his family orchard in Hutchison. From this bundle grew a thriving nursery business which became the world famous Stark Bro's Nurseries & Orchards Co.
By carefully selecting and propagating only the best varieties, James Stark started a tradition in horticultural excellence. This work of quality and excellence led to an association with famed plant wizard Luther Burbank. He personally selected Stark Bro's to carry on his work and willed over 750 varieties to the company. Today, Stark Bro's holds exclusive propagation rights to many patented varieties of fruit. Paul Stark Sr., in fact, was instrumental in writing U.S. legislation creating plant patents in the 1930s., and Stark Bro's continues to utilize those laws in developing their own new varieties. Through a dedication to quality, Stark Bro's has gained world leadership as a developer and promoter of outstanding fruit varieties. The most famous of these are the Stark Red Delicious Apple from 1893 and the Stark Golden Delicious Apple from 1914.
Stark Bro's continues to operate in the tradition of the past 194 years. Our president's father was instrumental in setting up the Stark Garden Center in Louisiana. Stark trees have been grown on their family farm for many years and continue to be grown there today.
In the Stark tradition, new and innovative products continue to be introduced through the Stark Bro's catalog and web site, including the new Stark Kwik Krop™ Fruit Tree, the quickest bearing trees ever offered. Most of Stark Bro's Custom Grafts and some fruit and nut trees are grown in "bottomless" pots to naturally air prune the roots, creating a dense mass that transplants and establishes quicker, eliminating loss due to transplanting, accelerating rate of growth and inducing early flowering and fruiting.
Stark Mother Lode™ Berries are cloned from the tissue of only the finest, most productive mother plants. All are uniform in size, shape, quality and growth patterns, certified disease and virus free and potted to keep the root system intact.
Stark Bro's intends to be at the forefront of the industry in innovation and productivity. You can look forward to many years of new Stark products to meet your fruit tree, small fruit, nut and landscaping needs in the future. As we move into this new century, look for us. We will be there.
Trees that are shipped without soil to ensure good contact with soil in your yard. When shipped, they are about 3-4' tall with 3/8" or larger trunk diameter. When they mature, they will be one of three sizes*:
Matures to be about 8-10' tall and wide. Provides an abundance of full-size fruit.
Matures to be about 12-15' tall and wide. Gives maximum fruit yield per square foot.
Matures to be about 15-25' tall and 20' wide. A multi-purpose fruit and shade tree.
Top-grade, bare-root trees that give you a head start on growing. When shipped, they are about 4-5' tall with 5/8" or larger trunk diameter.
Trees in bottomless pots that allow some roots to be air pruned, so that a dense mass of productive, feeder roots can grow within the pot to make transplanting easier. Mature sizes vary. When shipped, they are about 1-2' tall.
Top-grade, potted trees chosen to give you a head start on growing. When shipped to you, they are about 3-4' tall.
*Tree sizes may vary by variety. See our Growing Guide for details.
Since 1816, Stark Bro's has promised to please customers with the very best fruit trees and landscaping products, no matter what. It's just that simple. If for any reason you are not completely satisfied with your purchase, let us know within a year of delivery and we will send you a free one-time replacement or refund your full purchase price if you don't want a replacement. To receive your replacement or refund, please call 800.325.4180. This warranty gives you specific rights, and you may also have other rights, which vary from state to state.


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Archos 705 WiFi PVP on preorder
Amazon.com is now showing that the Archos 705 WiFi portable video player is now available for preorder.
Amazon.com is now showing preorder pages for the mythical Archos 705 WiFi portable video player. If you're in the market for a super-sized, Internet-ready PVP for the holidays, the 705 WiFi comes in 80GB and 160GB capacities for $399 and $499, respectively. For the price, you get a 7-inch, 800x480 touch screen, Mac/PC compatibility, and all the features found in the latest Archos 605 WiFi--most notably, the online content portal.
What do you think? Is the 705 making you salivate? Can a PVP ever be too big?


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Today's Best Country. Tomorrows hits today, Absolutely country now on 1.Fm
It's a FLASHBACK WEEKEND-EVERY DAY. All the biggest CLASSIC HITS from the 70s & 80s-Guaranteed No Repeat Workdays-Double Shot Every Hour - Badfinger Queen Firefall Van Halen Steve Miller Styx Foreigner Chicago Cars Journey Springsteen Doobies(100s more)
Playing classic country music. We've moved to 1.fm LOOK for us as Classic Country.
Country Music Hits from the 80's and 90's UPDATED February 2013
Boot Scoot'n Country - Your Hand Clap'n, Knee Slap'n, Foot Stomp'n Music
Playing high lonesome bluegrass from the roots to today's contemporary branches. If you like what you hear, invite your friends and family to join us.
Todays Hottest Top 40 Country Hits and your all time favorites ! Live365 Award Winner ! Toby Keith, Tim McGraw, Rascal Flatts, Alan Jackson, George Strait, Kenny Chesney, Reba
Hot Country Hits by Taylor Swift, Toby Keith, Carrie Underwood, Rascal Flatts, Kenny Chesney, Jason Aldean, Tim McGraw, Miranda Lambert, Sugarland, Alabama, George Strait, Trisha Yearwood, Lonestar, Keith Urban, and many more top country stars.
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CLASSIC ROCK...60s&70s...All the treasures that defined an era including, The Beatles, Led Zeppelin, Pink Floyd, The Doors, The Moody Blues, CSNY, Clapton, and other architects of the 60s and 70s consciousness.....
UPDATED 10/26/2007. You'll hear Led Zeppelin, The Beatles, Rolling Stones, The Guess Who, CCR, Boston, The Who, Bob Seger, Lynyrd Skynyrd, ZZ Top, Supertramp, The Moody Blues, Jimi Hendrix, The Eagles, and much, much more...
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Your favorite artists every day - Allison Krauss, Ralph Stanley, Nickle Creek, Seldom Scene, Ricky Skaggs, Earl Scruggs and more


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S. IL Davenport children?
My Aunt said that these two could be Davenport children. They were from Southern Illinois, and she believes they live in Anna, Saline County, IL. But...she is not sure. If anyone could help me out I sure would appreciate it. Thank you!
P.S. I have found a postcard to my G-Grandma Josephine (Travelst
... show more


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SAC Capital Advisors' Steve Cohen has again made headlines for his avid art collecting - this time for his purchase in May of "Turquoise Marilyn," a...
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The Bank Technology Management Strategies advisory service will focus on the enterprise-wide solutions and strategies banks are employing to serve customers, meet financial goals, and transform their business models. The banking industry is at a crossroads — recovering from the financial crisis and embracing new technology-based initiatives such as cloud computing, big data, social media, and mobile devices. In this service, we will discuss some of these broad topics, as well as core banking transformation, vendor management, and business process operations issues.
IDC Financial Insights' Bank Technology Management Strategies provides financial institutions and FinTech vendors with survey-based research and thought leadership analysis on key trends, including technology investment, banking trends, and technology renewal.
Throughout the year, this service will address the following topics:
- Cloud and its ability to transform business
- Customer onboarding solutions
- The impact of mobile on the banking workforce
- Vendor management
- Core banking strategies
Our research addresses the following issues that are critical to your success:
- How can vendors be effectively managed in hybrid environments?
- How can core banking investments be justified economically?
- What are best practices in vendor management?
- How will social media and mobile impact my institution?
- Which vendors are most appropriate to meet my needs?
Financial institutions and technology vendors that support the use of our research to guide their internal investment decisions, help them plan for future technology needs, benchmark the competition, and stay current on solution offerings. We also provide clients an open dialogue with our expert analysts to support key Financial Technology investment strategies.
- Guidance on technology trends impacting enterprise banking technologies and solutions
- Analysis of key technology providers and their approaches to the banking market
- Strategic advice on your initiatives and how they compare with peers
- In-depth research reports on some of the strategic investments that banks are making today
IDC Financial Insights values building client relationships and strives to foster a partnership with each client through continuous analyst interaction; timely delivery of current, concise, and relevant research; as well as custom research when needed. Each advisory service delivers strategic research covering business and technology issues. A summary of the basic service deliverables available to subscribers includes the following:
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Our IDC Insights Community is designed to enable technology buyers to engage with our industry analysts, share knowledge and best practices, and connect with colleagues. To participate in our community, members create a profile to:
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Related offerings to our industry-specific research practices include IT Spending Guides — segmented regional and country-level analysis by solution area; Go-to-Market Services (GMS) — a modular set of deliverables to assist clients in extending their market reach, validating their market strategy, and producing more responsive customer-centric marketing campaigns; and IDC Advisory Tools — a growing set of solutions designed to ensure clients that technology purchasing and deployment decisions are optimized. In addition, IDC Financial Insights experts are available for individualized consulting engagements to address specific challenges or to customize the results of our syndicated research offerings.


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Effect of L-arginine and Glutamine on Preterm (preterm)
The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2010 by Ain Shams University.
Recruitment status was Not yet recruiting
Recruitment status was Not yet recruiting
Ain Shams University
Information provided by:
Ain Shams University
ClinicalTrials.gov Identifier:
First received: December 17, 2010
Last updated: NA
Last verified: December 2010
History: No changes posted
- Full Text View
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
effects of enteral l-arginine to decrease feeding intolerance and risk of NEC in neonates via its role as a NO precursor. Also, enteral glutamine which may play a role as an immunomodulator on preterm neonates. all these had never been studied in developing countries where sepsis and nec act as a major participant in mortality rates.
Condition | Intervention | Phase |
NEC/Sepsis/Pulmonary Hypertension/Intracranial Haemorrhage/RDS |
Drug: enteral glutamine Drug: l-arginine Other: placebo |
Phase 2 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Single Blind (Caregiver) Primary Purpose: Prevention |
Official Title: | Effect of Early Enteral Supplementation of L-arginine and Glutamine on Preterm Neonate |
Resource links provided by NLM:
Further study details as provided by Ain Shams University:
Primary Outcome Measures:
- NEC incidence, stage and outcome [ Time Frame: age of 28 days of life ] [ Designated as safety issue: Yes ]determining the incidence, stage and outcome of NEC in both l-arginine recieving and control groups
- sepsis incidence, severity and outcome [ Time Frame: age of 28 days of life ] [ Designated as safety issue: No ]determining the incidence, stage and outcome of sepsis in both glutamine recieving and control groups
Secondary Outcome Measures:
- incidence, severity and outcome of RDS, pulmonary hypertension, intracranial haemorrhage [ Time Frame: age of 28 days of life ] [ Designated as safety issue: Yes ]incidence, severity and oucome of RDS, pulmonary hypertension, intracranial haemorrhage in the 2 studed groups compared to control
Estimated Enrollment: | 75 |
Study Start Date: | December 2010 |
Estimated Study Completion Date: | December 2012 |
Estimated Primary Completion Date: | December 2012 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Active Comparator: glutamine, PT, sepsis
effect of enteral glutamine on incidence, severity and outcome of sepsis in PT neonate
Drug: enteral glutamine
early enteral glutamine supplementation of VLBW and effect on 1ry and 2ry outcomes
Placebo Comparator: placebo
after been randomized, will receive nothing and observed for the same outcomes
Other: placebo
after randomization by blocks, this group will receive nothing and will be obeserved for effect on 1ry and 2ry outcomes
Active Comparator: L-arginine,NEC, PT
effect of l-arginine on incidence, severity and outcome of NEC in preterm neonate
Drug: l-arginine
early enteral l-arginin supplementation of VLBW and effect on 1ry and 2ry outcomes
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Gestational age ≤34 weeks
- Birth weight ≤ 1500 gm
Exclusion Criteria:
- Severe congenital anomalies.
- Congenital non-bacterial infection
- Evidence of intraventricular hemorrhage (IVH) grade ≥II on cranial ultrasound scan by day 3 of life
- Conjugated hyperbilirubinemia
- Evidence of an inborn error of metabolism
- Exchange transfusion during the study period
- Pre-existing kidney failure (<0.5 mL /kg per hour urine for >8 hours).
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01263041
Egypt | |
NICU of Children hospital and Nicu of obstetric and gynecology hospital, ain shams university | Not yet recruiting |
Cairo, Egypt, 11566 | |
Contact: hesham abdelsamie awad, Professor 0101433165 ext 002 firstname.lastname@example.com | |
Contact: maha m. hassan, Ass.Professor 0105287175 ext 002 email@example.com | |
Principal Investigator: Ghada a. saleh, ass.lecturer |
Sponsors and Collaborators
Ain Shams University
More Information
Additional Information:
Keywords provided by Ain Shams University:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 11, 2014
Additional Information:
Responsible Party: | Prof. Hesham Awad |
ClinicalTrials.gov Identifier: | NCT01263041 History of Changes |
Other Study ID Numbers: | ghada a. saleh MD protocol |
Study First Received: | December 17, 2010 |
Last Updated: | December 17, 2010 |
Health Authority: | Egypt: Ministry of Health and Population |
Keywords provided by Ain Shams University:
Glutamine, NEC, L-arginine,Preterm,Sepsis |
Additional relevant MeSH terms:
Hemorrhage Hypertension Hypertension, Pulmonary Sepsis Intracranial Hemorrhages Pathologic Processes Vascular Diseases Cardiovascular Diseases Lung Diseases |
Respiratory Tract Diseases Infection Systemic Inflammatory Response Syndrome Inflammation Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases |
ClinicalTrials.gov processed this record on March 11, 2014


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The Laughing Baby :: Baby and Puppy Meet For the First Time (VIDEO)
by Paul Heling12.7 million views... 1,746 thumbs down???? Who hates babies... or puppies?
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by Nikki MontgomeryPeople are naturally curious about multiples. Shortly after I announced I was having twins the questions started rolling in. Do twi...
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1st Solids
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My Kid Eats Mud...ummm...yeah....about that...
by Corey CarterThis is Cole, one of our twin boys. Of our two boys he seems to be the more devious of them...he doesn't listen to "no" very well,...
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A Lesson In Teaching Respect For Others - Pop Music Style
by Mark EvansI spent four years as the radio voice of Northern Michigan University. In the Wildcats locker room was a logo that NO ONE ever touc...
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Latest product recalls
by Nikki MontgomeryAs a mom I'm always concerned about product recalls so here's a list of the most recent product recalls for infants, toddlers and yo...
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Another Reason Not To Have Kids - Mommmm! Help!
by Jim ParishSure she's adorable, but come on kid... use a tissue... your sleeve... the drapes... anything!!! Ok maybe you don't have a proble...
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The Laughing Baby :: Hysterical Bubbles (VIDEO)
by Paul HelingWhat? 554 give this a thumbs down? How can that be?
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Monday, March 10, 2014
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You could soon have to be 21 to place a bet in New York State if two Queens lawmakers get their way.
The change is being proposed in a bill by Assemblyman Philip Goldfeder and Senator Joseph Addabbo, whose districts include the Resorts World Casino at Aqueduct Racetrack.
New York is one of the few states in the country where 18-year-olds can gamble.
Goldfeder says he is concerned after spotting gamblers under 21 at Resorts World, which is near several schools.
The bill comes months before New Yorkers will vote on whether to legalize Vegas-style casinos in the state.


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Ireland, 23 Feb 09
In the context of the Irish Society of Chartered surveyors' recent conference theme, Ireland's Future In A Global Economy, the major question was: is the role of the surveyor changing? From a global perspective, the answer is yes. Surveyors will contribute to the global agenda in an important way through the Millennium Development Goals. Simply stated, no development will take place without having a spatial dimension and no development will happen without the footprint of surveyors – the land professionals. There is a big swing that could be summed up in the phrase "from measurement to management." This does not imply that measurement is no longer a relevant discipline of surveying; the change is mainly in response to technology development. Collection of data is now easier, while the assessment, interpretation and management of data still require highly skilled professionals. The role is changing into managing the measurements. There is wisdom in the saying "all good coordination begins with good co-ordinates" and the surveyors are the key providers. The move from measurement to management includes an increased focus on the social science issues of the surveying disciplines, such as land tenure, land polices and land management. Surveyors play a key role in supporting an efficient land market and also effective land-use management. These functions underpin development and innovation for social justice, economic growth and environmental sustainability. The eight goals form a blueprint agreed to by all the world's countries and the world's leading development institutions. The first seven goals are directed at reducing poverty in all its forms. The last goal – global partnership for development – is about the means to achieve the first seven. The goals represent a wider concept of a vision for the future, where the contribution of the global surveying community is vital in providing the relevant geographic information in terms of mapping and databases of the built and natural environment, and also providing secure tenure systems for land valuation, land-use management and land development. The work of surveyors forms a kind of backbone in a society that supports social justice, economic growth and environmental sustainability. These aspects are all key concepts within the goals. From a global perspective, surveying and land administration are basically about people, politics and places. It is about politics in terms of human rights, engagement and dignity; it is about politics in terms of land polices and good government; and it is about places in terms of shelter, land and natural resources. In facing the global agenda, the role of the international federation of surveyors - the global surveying community – is threefold. It should explain the role of the surveying profession and the surveying disciplines in terms of their contribution to the goals. Such statements should also make the importance of the surveying profession disciplines better understood in a wider political context. It should also develop and disseminate knowledge, polices and methods towards achieving and implementing the goals- a number of International Federation of Surveyors publications have already made significant contributions in this regard. Finally, the federation should work closely with the UN agencies and the World Bank in contributing to the implementation of the goals. An outcome of these efforts relates to co-operation with UN-HABITAT in developing a model for providing secure social tenure for the poorest. Surveyors – nationally and globally – will have a key role as providers of the relevant spatial information and also as builders of efficient land tenure systems and effective measures for urban and rural land-use management. This should support economic growth, social equity and environmental sustainability Written by Prof Stig Enemark. Prof Stig Enemark is president of the International Federation of Surveyors and professor in Land management at Aalborg University, Denmark


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I am a third year student in the Fine Art depertment of Dublin Institute of Technology.
Born in 1961, Martin Hinchcliffe's early childhood was spent in the Middle and Far East. His family moved back to the UK in 1970 and Martin attended school in the South East of England before studying at Maidstone College of Art in 1979.In 1983 he graduated from Sheffield's Fine Art Painting
I was brought up in England and in the Languedoc region of France, where much of my family comes from.
My earliest encounter with Art was with Goya's Caprichos.
I became convinced of
Painter and Poet, Endri Kosturi, was born in Tirana, Albania in 1980. He started painting at a young age and his first painting (Spring, 1m x 2m) was exhibited in the National Art Gallery of Tirana, when the artist was only 7 years old. Tags: Abstract, Abstract expressionism, Abstract painting, Dense, Dreamy, Layered, Melancholy, Saturated, Tense, Urban


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Home » Undergraduate College » Admission » Art & Music » Courses
Please note
This course information is derived from the Online Course Catalog, which is under development. The information may not be accurate and is provided only as a convenience. Please consult the print or PDF version of the Course Catalog for all official course information.
How Music Works
4 sem. hrs. Discusses the music of many stylistic periods and their place within various societies. Studies examples of nontraditional notation leading to discussions and analysis of a range of compositions. Requires a basic understanding of music notation and familiarity with the keyboard. Builds on concepts from MUS 110. Note: MUS 110 and 111 are designed in sequence but may be taken separately.
Course details
- Course number: MUS-111
- Credits: 4.00
- Academic Level: Undergraduate
- Currently Offered: Yes
- Course Type: Lecture
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Truman State student's Facebook profile used in Kirksville investigation
One Truman State University student was surprised when her private Facebook status went public.
By Joshua Teasley (Columbia, Mo.)
Kirksville's Department of Public Safety made a house call earlier this month after a Facebook status a student wrote matched up with the rumor of a gun threat in the area. The status did not refer to an actual suspect, but rather relayed reports from earlier in the day. Despite this example, Truman State Student Affairs member Nicholas Sutherland says he is confident about his privacy settings.
"I don't think its ever happened to me, I don't think it will happen per se but pretty much you have to be a friend to get any of my information so unless personally I know you, you're not going to be able to get any of my personal information," Sutherland said.
Even on an account with the highest privacy setting, the Department of Public Safety officials were able to track down and contact the student who posted the status in question an hour after it was posted.
The Two-Way


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If you can't find the right words to thank your Dog Groomer, let the Whimsical Dog Groomer Watch say it for you. It features hand-crafted miniatures of a Poodle, clippers and perfume bottle. The perfect way to show your appreciation for your Dog Groomer.