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Tuesday April 6, 2004
I think that it is fair to say that those who were in attendance at the Twins home opener last night got their money's worth!! Just under four hours, and 11 innings after Brad Radke threw the season's first pitch to former Twin Matt Lawton, Shannon Stewart drilled an 0-1 pitch into the left field bleachers to give the Twins a 7-4 win.
Last night, the Minnesota Twins opened their regular season with a home game against their division rivals, the Cleveland Indians. It certainly did not start out well for the home nine. The Twins fell behind 4-0 after 6 innings. Brad Radke gave up all 4 runs (although just two were earned), three on home runs. North Dakota native Travis Hafner hit two homers, and Jody Gerut hit one just off the glove of Shannon Stewart over the left field fence. CC Sabathia was great, unhittable. After giving up two first inning hits, Sabathia did not give up another hit through seven innings. He struck out 7 and never really even struggled.
But then came the 8th inning. The Twins saw that a new pitcher was coming in, in the person of Jose Jimenez, the former Rockies closer brought into Cleveland to set up for David Riske. As Al Newman said in his postgame radio interview, it was like "a breath of fresh air." Joe Mauer walked (for the 2nd time in the game) and Cristian Guzman singled to right field. With Guzman on the move, Shannon Stewart grounded back to the mound for the first out. With runners on second and third and Luis Rivas due to hit, the Twins sent left-handed Michael Ryan to the plate. Cleveland's manager, Eric Wedge, countered by bringing in lefty Scott Stewart. It was just what Ron Gardenhire wanted, and he replaced Ryan with Michael Cuddyer. On the second pitch, Cuddyer singled up the middle, knocking in the Twins first two runs. Doug Mientkiewicz then singled off Stewart. Corey Koskie came up and drilled a ground rule double over the fence in left centerfield, scoring Cuddyer and holding Mientkiewicz at 3B. Torii Hunter hit a single to left field, scoring Mientkiewicz and tying the game at 4. Jacque Jones and Matthew Lecroy struck out against the new Indians pitcher, Rafael Betancourt, to end the inning.
The game remained tied until the 11th inning. Jacque Jones led off with his 4th strikeout of the game. Matthew Lecroy walked (And Nick Punto pinch ran). Joe Mauer knocked his second hit, another single, and Punto advanced to third base. Cristian Guzman had another terrible at bat, striking out with a runner on third and less than two outs. However, after taking one strike, Shannon Stewart came through with a long, game winning homer off Chad Durbin to give the Twins the win.
Random Twins Thoughts from Opening Day
Joe Mauer's big league debut was more than anyone could have hoped for. First, his presence meant almost 2,000 tickets were needed for his friends and family. Second, he was pretty good behind the plate. And offensively, he showed much of what has made him baseball's top prospect. He was patient. He walked in his first and third plate appearances. Even in his second at bat, when he struck out, he worked it to a full count. Then, in his final two plate appearances, he had solid singles. So, as of right now, he is hitting .667 with an .800 On-Base Percentage... think he can continue at that pace?
Michael Cuddyer should be playing every day. He came off the bench as a pinch hitter and came up with a big hit. Then he went in to second base and made a couple of plays. The highlight was when Omar Vizquel doubled into the right field corner and Matt Lawton tried to score from first. Cuddyer turned a perfect relay throw to Joe Mauer and they got Lawton on a close play. I think that he should spell Luis Rivas once or twice a week at 2B. I think that he should give Doug Mientkiewicz and Corey Koskie weekly (or every 10 games) days off. Then, he should play RF and LF to give those guys an occasional day off. Doing that, he should play 4-5 times per week, which should mean about 400 at bats this season. I also think that based on their injury histories, it would be good for Mientkiewicz and Koskie to get some time off. Oh, and if he continues to play well, don't be surprised to see Cuddyer become the full-time 2B at some point in the season.
Yeah, Jacque Jones can't hit lefties. It is that obvious. Against Sabathia (one of the better lefties in baseball), Jones was clueless. He struck out twice and walked once (I know, that is crazy!). Then, he struck out in two later at bats. Don't worry, I still think he will have a great season. I just really think that he should get days off against some hard-throwing lefties. That said, it was Opening Night, and it is my opinion that you put your regulars in the starting lineup for the announcements, and Jacque Jones deserves that!
You will hear comments about Shannon Stewart saying things like 'Now we see why the Twins signed him long term,' and the like. I think Stewart is a great player. I have no problem (anymore) with them giving up Bobby Kielty for him. Just one quick note. In reality, we got Shannon Stewart, and a minor league pitcher, for Bobby Kielty, LaTroy Hawkins and Eddie Guardado. You hate to look at it like that, but in the offseason, Terry Ryan made the decision to re-sign Stewart instead of the two pitchers. It is way too early to judge whether that was the right decision or not. Guardado was unable to pitch on Sunday because he couldn't get his arm loose. Hawkins struggled as Spring Training came to an end. Shannon Stewart played Hero last night (he was 2-5 with the 3 run homer), and he will be a very important player throughout the season.
The bullpen, which has been much maligned throughout the offseason and in spring training, definitely came through for the team last night. After Radke gave up the four runs in 6 innings, the bullpen pitched five scoreless innings. Aaron Fultz (7th), Joe Roa (8th), JC Romero (9th), Joe Nathan (10th) and Juan Rincon (11th) each gave up at least one baserunner, but did not allow a run.
Twins fans in attendance were introduced to the entire roster in the pregame ceremonies. They were introduced to most of them later in the game. Of position players, only backup catcher Henry Blanco and pinch-hitter Jose Offerman did not play. Of pitchers in the bullpen, only Carlos Pulido did not see action.
Have I mentioned that Joe Mauer is going to be good?
Have I mentioned that Michael Cuddyer is going to be a star?
Have I mentioned that I am annoyed that I did not get to see the game because my cable provider chooses not to get Victory Sports?
Have I mentioned that Justin Morneau should be DHing?
Have I mentioned that Ron Gardenhire deserves a lot of credit for this win?
Summary - Good win for the Twins. Excellent comeback. The lone concern is that they will see a lot of left-handed pitchers within the AL Central (CC Sabathia, Cliff Lee, Brian Anderson, Darrell May, Jeremy Affeldt, Mark Buehrle, etc.) and that's not even mentioning the likes of Mark Mulder and Barry Zito. They will need to do something to put a stronger lineup against them.
What did you think of the game? Were you able to watch it? E-mail me.
More Opening Day Thoughts
Why is the NCAA Basketball Championship Game always on on Opening Night? I hear Connecticut beat Georgia Tech by a bunch, but who really cares? There was baseball on TV!!
The Tigers crush Roy Halladay and the Blue Jays. The Pirates beat the Phillies. The Brewers beat the Cardinals. It all just makes the saying, "It's just ONE game" a pretty true saying. One game out of a 162 game schedule. Remember when the Devil Rays beat the Yankees on Opening Day from Japan? What happened the next day? And, well, what will happen as the season progresses. The Tigers, Pirates, Brewers and Devil Rays will probably still be the team's with the four worst records at season's end. But the beauty of opening day is that even the fans from those cities can dream! Don't take that away from them!
Roy Oswalt is still my NL Cy Young choice. But Barry Bonds made him look like Scott Klingenback. Two doubles, and then the big 8th inning three-run homer to tie the game. I didn't even put Bonds in my top three in NL Batting Average in my predictions. But, I should alter those thoughts. Bonds will probably walk 180 times this year. Could this be the year that someone (he) hits .400??? Scarily, it may be possible.
If you were Jimy Williams, do you keep Roy Oswalt in with 2 on and 2 outs in the 8th inning with Bonds coming up? Well, Grady Little got fired from Boston for keeping Pedro Martinez in the game in a similar situation last fall. I think Oswalt is your best pitcher, so I have no problem with him keeping Oswalt in the game there. That said, it's the first game of the year, he had already thrown a lot of pitches, Brad Lidge was ready. There is no right answer. Really, there isn't. The manager's job is to make a decision. If Oswalt gets Bonds out, no one even talks about it. If he brings in Lidge, and Bonds hits the homer, Williams made the wrong decision by taking Oswalt out. It's a no-win situation for the manager. So, really, lay off!!!
Craig Wilson really, really can hit. He also really, really needs a haircut.
Kenny Rogers was Kenny Rogers last night. Keeping the Oakland hitters off balance for 7 innings and leaving the game with his team ahead 4-3. Sometimes, it isn't just about how hard you can throw and how many you can strike out. Sometimes it is just about giving your team a chance to win. Of course, the Rangers lost the lead after Rogers left the game with Oakland winning 5-4.
The fan in me would really like to see that Cincinnati outfield of Adam Dunn, Ken Griffey and Austin Kearns. I want them all in the lineup 150 times this year. However, Griffey already sat out Opening Day. The team was saying that it was just precautionary, but other sources insist that he could be traded soon. All I know is that I don't think I want to see Wily Mo Pena swing any more!
Mendy Lopez? Mendy Lopez? He may not hit more than 2 or 3 more homers this season. But that was a good one.
Why did Carlos Beltran throw his helmet before jumping into the Royals mob at home plate following his game-winning home run off Damaso Marte? I think I would want to keep my helmet, shin pads, elbow pads and any other equipment I could find because those mobs would be painful!
Speaking of the White Sox/Royals series, who am I supposed to cheer for? I want both of them to lose. I was happy that Billy Koch and Damaso Marte struggled, but I don't want the Royals to win, especially not in such dramatic fashion. Maybe I want them to just split.
A few guys had very disappointing 2003 seasons, but got off to a good start in 2004. Paul Konerko was 3-4. Juan Gonzalez was 2-4. Pat Burrell was 3-4. Ben Grieve was 2-4 with a homer and 3 RBI. Was it an Opening Day fluke, or a sign of things to come?
Kip Wells is very underrated. His win-loss record for Pittsburgh should not be looked at. He has good stuff and last year, had an ERA just over 3.00. Expect his name to be mentioned in trade rumors before the deadline.
Milton Bradley went to the Los Angeles Dodgers. Yesterday, he was inserted into the 3 hole of the Dodgers lineup. He had singles in his first two at bats.
Some may think that the Indians gave up on Bradley too quickly, and maybe they're right. However, they came out just fine in the deal. Now, they don't have to deal with Bradley's attitude. Some may think team chemistry doesn't matter in baseball. I think Milton Bradley can really hurt a clubhouse, specifically a young clubhouse like Cleveland's. Also, the Indians got a great hitting prospect in OF Franklyn Gutierrez. The 20 year old moved up to AA last year. By the end of next year, maybe even by September, the Indians could have a starting outfield of Gutierrez, Grady Sizemore and Jody Gerut. I like the way the Indians GM Mark Shapiro works.
That's it for my thoughts on Opening Day. It was full of good baseball, and it is just great that the season is on!
Any baseball thoughts? How 'bout them Twins? If you have any questions or comments on anything, send me an e-mail.
And because this is so short, check out the postings from recent days.


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Lightening Video Games
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... From Final Fantasy 13
Created Jan 22, 2009. Unless noted Copyright 2009
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WOW. I didn't expect someone could draw a final fantasy character as realistic as one on Flash. THIS IS WHAT SKILL LOOKS LIKE!!!!!!!! YOU DID SUPER!!!!!
I love how you did her hair!! This doesn't look like it was made with flash O.o
I tried to play the game but it was too hard. But you drew Lightning perfectly! 5/5 hearts definitely.
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Easy Chocolate Drops Recipe
Friends and relative of Heather De Cal, from Terrace Bay, Ontario, relish these crunchy goodies she gives.
- 1 cup (6 ounces) semisweet chocolate chips
- 1 cup butterscotch chips
- 1 cup shoestring potato sticks
- 1 cup salted peanuts
- In microwave-safe bowl, melt chips; stir until smooth. Stir in potato sticks and peanuts.
- Drop by teaspoonfuls onto waxed paper-lined baking sheets. Refrigerate for 15 minutes or until set. Store in airtight containers. Yield: 3-1/2 dozen.
Editor's Note: This recipe was tested in a 1,100-watt microwave.
Originally published as Easy Chocolate Drops in Taste of Home
December/January 1997, p18
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Reviewed Mar. 24, 2011
So easy and so delicious. I would definitely make this again.
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House Judiciary Committee
Election and Ethics Laws Subcommittee
ELECTION AND ETHICS LAWS SUBCOMMITTEE The following is a list of bills which may be discussed at the Election and Ethics Laws Subcommittee meeting on Wednesday, January 23, 2013, at 11:00 a.m.. in Room 516 of the Blatt Building.
H. 3197 State Elections Commission Rep. Clemmons
This is not an exclusive list of bills to be discussed. The agenda is subject to change. The members may bring up and discuss any bill presently in subcommittee.
Last Updated: Thursday, January 17, 2013 at 4:41 P.M.


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[JURIST] Iraqi government sources Saturday unveiled a plan to proclaim emergency laws in troubled central areas of Iraq, including Falluja and Ramadi. A spokesperson for the Iraqi Interior Ministry stated that the emergency laws could be imposed without declaration and would restrict land and water transportation. In addition, a civilian curfew will be enforced and a total ban on the carrying of arms will be imposed. Under the emergency laws, also known as National Safety Law, the Iraqi Prime Minister has authorization to any issue military orders to enforce security in rebel territories. The Kuwait News Agency has more.
[JURIST] Concluding its 82nd session in Geneva, the UN Human Rights Committee asked the United States on Friday to delineate the legal status of inmates in Afghanistan, Guantanamo Bay, and Iraq. The US, which has been sharply criticized by human rights groups for abuses, is six years overdue on its regular report to the Committee on its compliance with the 1976 International Covenant on Civil and Political Rights. Reports are generally due every four years and cover such topics as protection of the right to life, self-determination and due process, and freedom of movement, expression and religion. Brooks Robinson, spokeswoman at the US diplomatic mission in Geneva, said that Washington will file its report in the next few months and that the response will address relevant activities of the US armed forces. Reuters has more.
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[JURIST] Former governor of East Timor, Abilio Jose Soares, was released late Friday from Jakarta's Cipinang prison. Soares' 2002 conviction in 2002 for failing to prevent violence that erupted after the East Timorese voted on a United Nations sponsored referendum for independence was overturned by the Supreme Court in Indonesia. The court concluded that he had no role in the security of East Timor nor in the deaths of the 2,000 East Timorese who died in the hostilities. AP has more.
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First Alert Forecast: Pleasant weekend on the way
UPDATED 12:55 PM EDT Nov 02, 2012Sandra says a mild and dry weekend is on tap around the Palm Beaches.
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Video: Anthony Valadez – "Asleep" ft. Anna Wise (Sonnymoon)
July 26th, 2012
[kml_flashembed movie="http://www.youtube.com/v/F-tlDZw7egE" width="550" height="445" allowfullscreen="true" fvars="fs=1" /]
This album is a such a gem. Anthony Valadez has got a new video for another Just Visiting track called "Asleep" featuring the mystical Anna Wise of Sonnymoon on lullaby duty. We've totally spaced out to this track about seven times already and forgot to finish this post. Loving the dim evening mood to this video - it's so dreamy.
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Catherine Connors
I think the question, how am I empowering women through my blog, is better phrased as, how am I being empowered - by blogging and by this community – and how am I using that empowerment to make a difference? I use the power that my readers give me (by reading and responding to and sharing my stories) to lift the veil on women's, and especially mothers', real lives, and by urging others to use their storytelling platforms to inspire each other to work for real change in and through those lives, and the lives of others who need inspiration and empowerment.
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Charging My Lazor
by Resurgence Tees
iPhone & iPod Skin
Skins are thin, easy-to-remove, vinyl decals for customizing your device. Skins are made from a patented material that eliminates air bubbles and wrinkles for easy application.
For this piece I wanted to delve into more complex illustrations, so constructing elements out of multiple brush strokes and textures layered on top of one another, this intergalactic spacebug – charging his lazor[!] of spirographs and wisps of energy – was born.
- 25Promote


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Copyright © 2008 All rights reserved.
Cell Stem Cell, Volume 2, Issue 1, 34-37, 10 January 2008
ISSCR: Meeting Report
Add/View Comments (0)Stem Cells Shine in Shanghai
Linzhao Cheng1, , , Lei Xiao2, Fanyi Zeng3 and Y. Alex Zhang4
1 Stem Cell Program, Johns Hopkins Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
2 Shanghai Institute of Biochemistry and Cell Biology, Key Laboratory of Stem Cell Research, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
3 Shanghai Institute of Medical Genetics and Shanghai Key Laboratory for Developmental Biology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
4 Xuanwu Hospital, Capital Medical University, Beijing 100053, China
- From November 6 to 9, 2007, more than 500 scientists from 20 countries and regions gathered in Shanghai, China, to attend the 2007 Shanghai International Symposium on Stem Cell Research. This dynamic meeting was jointly organized by the International Society for Stem Cell Research (ISSCR), the Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (SIBS/CAS), and other institutes in China. For the first time, the ISSCR added its name to a conference other than its own annual meeting, embracing this opportunity to learn more about research that is happening in China and providing a platform for local researchers who do not always have the opportunity to travel internationally to the ISSCR annual meetings. Here we present a sampling of the diverse research presented by the local and international participants during the science-packed 4 day meeting.
Main Text
The Shanghai symposium was a concentrated, interactive meeting, providing researchers with many opportunities to discuss their work and hear that of others. More than 70 investigators gave oral presentations, and two poster sessions were held with 102 submitted abstracts. Many investigators focused on recent, unpublished findings.
Derivation of New Pluripotent Stem Cells, the Germline, and Embryology
Qi Zhou (CAS, Beijing) shared his experience in somatic cell nuclear transfer (SCNT) in various animals ranging from mice and rats to cows and monkeys as part of his studies of reprogramming and the developmental events of early embryos. In addition, Zhou and collaborators in Guanzhou and Shanghai have established two parthenogenetic human embryonic stem cell (ESC) lines (Mai et al., 2007). A further report of a parthenogenetic human ESC line was made by Ge Lin in Guanxiu Lu's group (Central South University, Changsha, China), who derived a line from an activated oocyte following a standard in vitro fertilization (IVF) procedure (Lin et al., 2007). In the latter study, it seems the oocyte was not fertilized but was somehow activated by the IVF procedure, resulting in one pronucleus in the center of ooplasm with a second body extrusion. After 5 days of culture, it developed into the blastocyst stage and, despite poor morphology, an ESC line was established and propagated. Molecular analyses revealed that the derived human ESC line is parthenogenetic with a high degree of homozygosity. These reports, together with two others earlier this year (Kim et al., 2007,Revazova et al., 2007), suggest that derivation of human parthenogenetic ESC lines may not be as difficult as previously thought.
George Daley (Harvard Medical School and Children's Hospital Boston, Boston) first described efforts in his laboratory to derive human ESC lines using poor-quality embryos after IVF. He reported that they established 11 human ESC lines from day 3–5 IVF embryos that would otherwise be discarded without clinical use (Lerou et al., 2007). Daley also reported their latest findings to reprogram human somatic cells using a procedure similar to that first described by Yamanaka and colleagues at Kyoto University (Kyoto, Japan) (Takahashi and Yamanaka, 2006). Although the four factors described by Yamanaka (Oct4, Sox2, Klf4, and c-Myc) were sufficient to reprogram human fetal lung fibroblasts back to an ESC-like state, reprogramming postnatal human cells occurs with much lower efficiency and required supplemental factors to generate induced pluripotent stem (iPS) cells in Daley's laboratory (Park et al., 2007). Together with other reports published since the meeting (Takahashi et al., 2007,Yu et al., 2007), this marks the first wave of direct reprogramming of human somatic cells to iPS cells with few defined factors, similar to successful stories with mouse cells published by several laboratories. Konrad Hochedlinger (Massachusetts General Hospital, Boston) reported his progress in characterizing mouse iPS cells, including their epigenetic properties, a critical comparison needed to establish the full picture of similarities and differences between ES cells and iPS cells. Holm Zaehres (Max Planck Institute for Molecular Medicine, Münster, Germany) talked about GFP reporter systems under the control of an Oct4 or Nanog promoter element. These novel systems may aid us in monitoring more efficiently reprogramming of human somatic cells.
Sheng Ding (Scripps Institute, La Jolla, CA) introduced a chemical screening approach to identify small molecules with applications in stem cell biology. His group identified a novel molecule that substitutes for LIF in the propagation of undifferentiated mouse ESCs. This molecule also appears useful to derive ESC lines from other species. Ding also reported efforts to substitute small molecules for transgene expression in the reprogramming of mouse somatic cells to an ESC-like state. Using reprogramming of mouse tissue-specific progenitor cells as defined model systems, only two of the four transgenes were required to derive mouse ESC-like cells.
Wenzhi Ji (Kunming Institute of Zoology/CAS, Kunming, China) focused his talk on the characterization of rabbit ESC lines. They resemble primate (monkey and human) ESC lines rather than their mouse counterparts in cell-surface marker expression and responses to BMP4, activin/nodal/TGFβ, and bFGF. Furthermore, the derived rabbit ESC lines readily differentiate into trophoblast cells spontaneously or upon BMP stimulation, as reported for primate ESCs but in contrast to mouse ESCs (Xu et al., 2002). Bertrand Pain (Ecole Normale Superieure de Lyon, Lyon, France) reported the molecular characterization of chick ESCs, cultured blastodermal cells from which they had derived the ESCs, and germinal cells. The chick ESCs expressed at high levels a set of key genes associated with pluripotency, including cPouf5 (also known as Oct3/4), Nanog, and Gcnf.
Fanyi Zeng (Shanghai Institute of Medical Genetics and Shanghai Jiaotong University School of Medicine, Shanghai, China) reported the characterization of global changes in gene expression and the identification of key molecular processes in mouse preimplantation stages that accompany and likely underlie the important transitions in early mouse embryos. For example, fertilization resulted in changes in the transcript profile in the one-cell embryo that were far greater than previously recognized, and genome activation during the two-cell stage was quite selective rather than global and promiscuous. To investigate other factors affecting early embryonic development and reprogramming, they used bovine embryos and SCNT to explore the effects of mitochondrial DNA haplotypes on SCNT embryo development. They found that the mitochondrial structure, quantity, and functions significantly affect the developmental competence of reconstructed embryos (Jiao et al., 2007). Zichuan Liu of Nathalie Beaujean's group (Institut national de la recherche agronomique [INRA], Jouy en Josas, France) reported on their analysis of trichostatin (TSA) effects on the reorganization of nuclear structure in mouse parthenogenetic embryos. Interestingly, TSA treatment resulted in extended survival of parthenogenetic fetuses after embryo transfer.
Karim Nayernia (University of Newcastle upon Tyne, Newcastle upon Tyne, UK) presented a hypothesis in which certain somatic cells could be direct descendants of the germ lineages. He also reported progress on ESC-derived gametogenesis. Lixin Feng (Shanghai Jiaotong University School of Medicine, Shanghai, China) reported his work on improving mouse ESC-derived gametogenesis by expressing a germline-specific transgene encoding Dazl. Both sperm-like and oocyte-like cellular structures were formed from R1 mouse ESCs (XY karyotype) after Dazl transduction and in vitro germline differentiation.
Haifan Lin (Yale University, New Haven, CT) reported his progress in functional studies of the Piwi protein family and Piwi-interacting RNAs (piRNAs). The RNA-binding proteins, Piwi and its mammalian homologs Miwi and Miwi-like (or Mili) in mice and Hiwi in humans, appear to be critical to stem cell self-renewal in diverse organisms. There are at least 60,000 species of their target piRNAs, each 26–32 nucleotides in length. As piRNAs can positively regulate mRNA stability, and possibly translation and epigenetics, this represents a brand-new mechanism crucial for regulating stem cell functions (Yin and Lin, 2007).
Adult Stem Cells and Their Niches and Regulation Mechanisms
A major theme of the meeting was the importance of the microenvironment, or niche, that maintains stem cells throughout development and adult life. Linheng Li (Stowers Institute for Medical Resaarch, Kansas City, MO) proposed a new model in which distinct subpopulations of hematopoietic stem cells (HSCs) exist in the bone marrow of adults. These subpopulations of HSCs can be distinguished according to the levels of N-cadherin expression. Toshio Suda (Keio University, Tokyo) summarized the molecular interactions between the osteoblastic niche and HSCs and then showed that N-cadherin is expressed in HSCs and is important for their function. Presenting data from an animal model in which the Hif1α gene was inactivated in HSCs, Suda also showed that levels of intracellular reactive oxygen species (ROS) were critical for determining HSC life span. Hong Qian from Sten Erik Jacobsen's and Marja Ekblom's groups (Lund University, Lund, Sweden) discussed distinct roles for integrins α6 and α4 in fetal liver hematopoietic stem and progenitor cell homing. She also described a role for thrombopoietin as a part of the niche, in the regulation of posttransplantation HSC expansion as well as the maintenance of adult quiescent HSCs, a critical mechanism to avoid postnatal HSC exhaustion. This and a similar study from Suda's group have since been published (Qian et al., 2007,Yoshihara et al., 2007).
Tao Cheng (University of Pittsburgh, Pittsburgh, and Tianjin Institute of Hematology, Tianjin, China) reported his long-standing studies on the roles of cell-cycle regulation and adult HSC self-renewal. He and others have previously demonstrated that the cyclin-dependent kinase inhibitors p21, p27, p16, and p18 are involved in adult stem cell regulation. They directly compared roles of p18 and p21 in regulating murine HSCs using knockout mice and bone marrow transplantation systems (Yu et al., 2006). HSCs that lack p18 had a striking advantage over p21 null or p27 null cells in long-term engraftment experiments. Tariq Enver (University of Oxford, Oxford) reported that nephroblastoma overexpressed (Nov or CCN3) is an important regulator of human HSCs or progenitors. A knockdown diminishes HSC/progenitor function, while its overexpression enhances stem cell activity.
The niche in the regulation of neural stem cells was also the subject of research for many scientists at the meeting. Hongjun Song (Johns Hopkins University, Baltimore) presented his elegant work on identifying the factors that are involved in maintaining the neural stem cell niche within the dentate gyrus of adult mice. He also presented data on how newly generated neurons integrated into existing neural networks. Weimin Zhong (Yale University, New Haven, CT) used both fly and mouse models to demonstrate that the Numb-mediated symmetric cell division is a mechanism by which neural stem cells choose between self-renewal and differentiation during development. Lingsong Li (Peking University Stem Cell Research Center, Beijing) reported his recent discovery that the Pax6-Sox2-FGFR pathway is required for neural stem cell proliferation during the development of cerebral cortex.
Ting Xie (Stowers Institute, Kansas City, MO) reported that Notch signaling is required for germline stem cell (GSC) niche formation and maintenance in the Drosophila ovary. During early development, ectopic Notch activation leads to expansion of the niche size, and its reduction results in the reduced niche size and the GSC number, while the absence of Notch signaling causes loss of the niche in adults. Finally, Xie showed that GSC aging is controlled extrinsically and intrinsically, and manipulation of the niche signal, adhesion, and ROS-induced cellular damage can modulate the stem cell aging process (Pan et al., 2007).
ES Cells: Self-Renewal and Pluripotency Mechanisms
Ying Jin (SIBS/CAS and Shanghai Jiaotong University School of Medicine, Shanghai, China) reported her recent work demonstrating that downregulation of nucleolar protein, LYAR, in mouse ESCs significantly reduces cell proliferation, anchorage-dependent growth, and teratoma formation. She showed that LYAR forms a protein complex with nucleolin, thus stabilizing nucleolin by preventing autodegradation. Gen-Sheng Geng (Xiamen University, Xiamen, China, and Burnham Institute, La Jolla, CA) discussed roles for Shp2, an intracellular tyrosine phosphatase with two SH2 domains, in regulation of human and mouse ESC differentiation. In mouse ESCs, Shp2 modulates LIF and BMP signaling through Erk, Stat3, and the Smads and in human ESCs modulates the FGF and BMP pathways via Erk and Smads.
Linzhao Cheng (Johns Hopkins University, Baltimore) focused his talk on using human ESCs as a research model for studying human cell biology and diseases. After several years of efforts, they generated two clonal human ESC lines lacking the expression of phosphatidylinositol glycan class A (PIG-A), which is required for the synthesis of a glycosyl phosphatidylinositol (GPI)-anchored cell-surface molecules and often mutated in HSCs of patients with PNH (a rare somatic hematological disease). Lei Xiao (Shanghai Institute of Biochemistry and Cell Biology, SIBS/CAS, Shanghai, China) extended his previous studies demonstrating that activin can aid maintenance of human ESCs (Xiao et al., 2006). He reported that blocking activin/nodal/TGFβ signaling in human ESCs by selective inhibitors induced the loss of pluripotency, resulting in trophoblast differentiation as when treated by BMP4. Renhe Xu (University of Connecticut, Farmington, CT) reported that, although both FGF and activin positively regulate the growth of undifferentiated human ESCs, the mechanisms of action are different; FGF signaling promotes proliferation, while activin does not stimulate cell proliferation.
Directed Differentiation of Embryonic Stem Cells
Xin Wang (Shanghai Institute of Biochemistry and Cell Biology, SIBS/CAS, Shanghai, China) reported work in his lab to generate functional hepatocytes from mouse ESCs in vitro. Activation of both Wnt and nodal signaling can result in production of definitive endodermal cells at 80%–90% of the total ESC-derived cells. Further differentiation protocols and functional assays are under test.
Huangtian Yang (SIBS/CAS and Shanghai Jiaotong University School of Medicine, Shanghai, China) investigated the regulation of calcium signaling during differentiation of ESCs into cardiomyocytes and neuronal cells. Using mESCs as an in vitro model, her lab demonstrated that, in the differentiation of ESC-derived cardiomyocytes, functional RyR2, the type 2 ryanodine receptor, is essential to the rapid uptake and frequency of calcium transients that regulate contractions. Neurogenesis induced by activation of GABAA receptors and L-type calcium channels depends critically on a functional RyR2.
Ronald Li (University of California, Davis, Davis, CA) reported efforts in his group to use various cell- and gene-based approaches to differentiate human ESCs for cardiac tissue regeneration. Zack Wang (Maine Medical Center Research Institute, Scarborough, ME) reported his progress in generating CD34+ vascular progenitor cells from human ESCs under animal-product-free conditions by adding BMP4, VEGF, and bFGF sequentially. Hongkui Deng (Peking University, Beijing) reported his recent studies using human ESCs to generate insulin-producing cells in vitro by mimicking the pancreatic islet development process. The differentiated cells morphologically form islet-like clusters and can express islet-specific markers such as C peptide, pdx1, insulin, glucagon, and glut2. They can not only secrete insulin and C peptide in response to glucose stimulation but also rescue hyperglycemia in STZ-induced diabetic nude mice.
Su-chun Zhang (University of Wisconsin, Madison, WI) presented his work on directed differentiation of human ESCs to the neural lineage. In the past several years, Zhang has developed a chemically defined in vitro system in which human ESCs can differentiate into the primitive and the definitive neuroectoderm. Based on such a model system, Zhang was able to further induce definitive neuroectodermal cells into different types of nerve cells, including the forebrain glutaminergic and GABAergic neurons, midbrain dopaminergic neurons, spinal cord cholinergic neurons, and myelinating oligo-dendrocytes. Wei Cui (Imperial College, London) presented her work on directed differentiation of human ESCs into first the definitive endoderm and then hepatocytes. Both Zhang's and Cui's work underscored the potential of a defined in vitro system of human ESC differentiation to recapitulate the process of normal organ development of the body for better future applications.
Stem Cell Applications
Various speakers presented their data on extending the stem cell research into the application arena. Alan Colman (A∗STAR Institute of Medical Biology, Singapore) led the way by providing a review of the challenges facing new stem cell therapies. He pointed out that, in addition to the necessary technological advances, safety and regulatory compliance (e.g., GMP production) remain a major hurdle. In part addressing the safety issue of stem cell therapy, Alex Zhang (Xuanwu Hospital, Beijing) pointed out that studies with nonhuman primates is a necessary step before new stem cell-based therapies can be used for human patients. Zhang's lab has been working on diabetes and Parkinson's using monkey models to test the efficacy and safety of cell therapy and has shown that β cells derived from adult pancreatic progenitor cells were able to ameliorate hyperglycemia in diabetic monkeys for at least 6 months.
Wei Han (Shanghai Jiaotong University, Shanghai, China) described the use of chemokine CXCL9 (also known as Mig) as a bone-marrow-protective measure prior to chemotherapy that otherwise preferentially kills proliferating hematopoietic progenitors cells in addition to the target cancer cells. CXCL9/Mig acting through its receptor CXCR3 on bone marrow cells inhibits G1 to S phase transition of these cells, reducing the toxic effects of chemotherapy agents such as 5-FU both in vivo (mice) and in vitro. This study suggests that it may be developed as a new myeloprotective drug in cancer therapy. Xuetao Pei (Beijing Institute of Transfusion Medicine, Beijing) presented his work on a 3D bioreactor that would facilitate the function of hepatocytes derived from hepatic stem cells. Hung-Fat Tse (University of Hong Kong, Pokfulam, Hong Kong) reported on their randomized, controlled clinical trial using autologous bone marrow cells in treating severe ischemic heart diseases.
Global Issues/Beyond the Science
To conclude the meeting, speakers looked beyond the immediate technical challenges of the field. Jeremy Sugarman (Johns Hopkins University, Baltimore) discussed bioethics issues related to stem cell research and treatment as both a physician and a seasoned ethicist. From his position as cochair of the Johns Hopkins Embryonic Stem Cell Research Oversight Committee (ESCRO), he introduced current practices of stem cell research oversight and the human subject protection provided by the Institutional Review Board (IRB) in U.S. biomedical research institutes. Among many new issues and challenges raised by stem cell research and related applications, Sugarman emphasized the importance of the Hippocratic oath—to help and do no harm—in the treatment of patients. Supporting what John Gearhart had discussed in his opening keynote speech, Sugarman warned of the risks in rushing to claim effective stem cell therapies as seen in some cell-based interventions prematurely or inadequately conducted and publicized.
Good communication of research cannot be emphasized enough both for individual scientific success and in driving the field forward in a global and collaborative fashion. Deborah Sweet (Editor, Cell Stem Cell and Developmental Cell, Cambridge, MA) and Monya Baker (Nature Publishing Group, San Francisco, CA) shared their expertise with investigators on how to publish high-profile papers. Douglas Sipp (Riken Center for Developmental Biology, Kobe, Japan), chair of the ISSCR's International Committee, described ISSCR international activities and membership. He also introduced other international and regional collaborations such as a CAS-sponsored international conference in Beijing on April 18, 2008, and the commencement of the Stem Cell Network for the Asia and Pacific (SNAP).
We thank Guotong Xu, Ying Jin, and Linheng Li for co-organizing this meeting in collaboration with the ISSCR. We also thank Ting Xie for his contribution to this report. We apologize that many other exciting findings could not be covered by this report due to limited space.
Jiao et al., 2007 (2007). Mol. Reprod. Dev. 74, 1278–1286. CrossRef | PubMed
Kim et al., 2007 (2007). Cell Stem Cell 1, 346–352. PubMed
Lerou et al., 2007 (2007). Nat. Biotechnol. . doi:10.1038/nbt1378 | PubMed
Lin et al., 2007 (2007). Cell Res. 17, 999–1007. CrossRef | PubMed
Mai et al., 2007 (2007). Cell Res. 17, 1008–1019. CrossRef | PubMed
Pan et al., 2007 (2007). Cell Stem Cell 1, 458–469. PubMed
Park et al., 2007 (2007). Nature , doi:10.1038/nature06534 | Published online December 23, 2007. PubMed
Qian et al., 2007 (2007). Cell Stem Cell 1, 671–684. PubMed
Revazova et al., 2007 (2007). Cloning Stem Cells 9, 432–449. CrossRef | PubMed
Takahashi and Yamanaka, 2006 (2006). Cell 126, 663–676. Abstract | Full Text | PDF (1296 kb) | CrossRef | PubMed
Takahashi et al., 2007 (2007). Cell 131, 861–872. Abstract | Full Text | PDF (2210 kb) | CrossRef | PubMed
Xiao et al., 2006 (2006). Stem Cells 24, 1476–1486. CrossRef | PubMed
Xu et al., 2002 (2002). Nat. Biotechnol. 20, 1261–1264. CrossRef | PubMed
Yin and Lin, 2007 (2007). Nature 450, 304–308. CrossRef | PubMed
Yoshihara et al., 2007 (2007). Cell Stem Cell 1, 685–697. PubMed
Yu et al., 2006 (2006). Blood 107, 1200–1206. CrossRef | PubMed
Yu et al., 2007 (2007). Science , doi:10.1126/science.1151526 | Published online November 20, 2007. PubMed


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Found 414 Recipes | Revise this Search New Search |
New York Style Cheese Cake
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Definition of yarn-dyed in English:
Line breaks: yarn-dyedadjective
- (Of fabric) dyed as yarn, before being woven.More example sentences
- Girouard notes that the denim looks like a yarn-dyed product when it is garment dyed.
- Lew also said yarn-dyed Tencel fabrics in large plaids were being picked up for both men's and women's wear.
- The fabrics include washed denims, soft poplins, heavy canvas, twills, and yarn-dyed plaids.


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Rainbow Room's Chefs Will Mine 75 Years of Menus for Relaunch
There will most definitely be classic cocktails on the menu.
Skip to content, or skip to search.
Skip to content, or skip to search.
There will most definitely be classic cocktails on the menu.
Ideally, said chef will have a really good recipe for crab cakes.
After two years of sitting empty, the Rainbow Room at last sees some action.
The search for a tenant has apparently been suspended.
Lenders are owed over $3.6 billion — not that they're going to get it.
And why is he ranked below the Speyers?
Rather than face a painful and protracted foreclosure, the two companies have given up the massive apartment complex.
This means foreclosure will likely come sooner rather than later.
They were judged to have improperly deregulated rent-stabilized apartments.
Sources tell the paper that, at maximum, the investment group headed by Tishman Speyer and BlackRock has until February before they run out of cash to service their debt on the massive property.
Though, I'll admit, I'm not above chuckling about it.
A judge ruled that they may owe tenant up to $200 million for illegally raising rent and deregulating apartments.
Are the Ciprianis becoming the Blagojevich of the restaurant world?
The actress smoothly buys into a hard-to-crack co-op, while JPMorgan and the New York 'Times' struggle, in our daily digest of real-estate, finance, media and law news.
"Wall Street got drunk," the president said, "and now it's got a hangover." Also, Donald Trump Jr. invests in India, 'Esquire' editors decide to flash people, and more, in our daily roundup of finance, real-estate, media, and law news.
Also, Lehman Brothers weighs its options, and 15 CPW breaks the $100 million barrier.
A dating blogger seeks a book deal, trading desks think recession, and Jean Nouvel wins the Pritzker in our daily roundup of media, finance, law, and real-estate news.


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I am looking for information on data plans and pricing for 3G ipads on Verizon. I can't find it easily on the site, maybe someone could help?
The only stuff I see is http://picfu.net/8c37e7/original.png, but it doesn't speak about international data roaming. Please advice, Thank you.
I found this on google I dont know if its correct or not
Verizon: $0.002/ KB Canada; $0.005/ KB Mexico; $0.02/ KB everywhere else
Thanks @MrHicks. If you can give me the URL where you found it please so I can confirm if it is correct. Thank you.
For information on using your voice and data services outside the United States, please click on the following link:
The international roaming rates are the reason that I bought an iPad from AT&T. The GSM version of the iPad allows you to use a local SIM when traveling. I just returned from Taiwan, where I spent under $25 (US) for one month of unlimited data on my iPad. I used 750MB in 12 days, which would have cost $15,000 if I had been roaming.


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It's official. We're in a drought. Everyone in whitetail country is experiencing reduced rains in one degree or another, and for now there's no relief in sight. This is nothing new. Every few years the man upstairs shuts off the spigot. There's not much you can do unless you're lucky enough to own water rights for irrigation, but even those are monitored and being shut down as fast as a government whistleblower.
The United States Department of Agriculture (USDA) rates only 24 percent of the nation's corn crop in good to excellent condition, with a similar rating for soybeans. That means nearly 75 percent of the nation's corn crop is withering and soybeans are close behind.
Whitetails are adaptable, thus the reason for their expansion into the North Country and throughout urban backyards. Before the European invasion and the introduction of modern farming, whitetails were strictly browsers, not dinner guests to manicured farm fields.
If your food plot or favorite farmland buffet is drying up, try these tips.
1. Irrigate a plot. A small food plot doesn't take much water. An old well, a tap in a rural water system or even flood irrigation via a portable water tank can keep a small food plot green and attracting deer. Be creative and keep a small plot flourishing.
2. Water your buck. Even if your food attraction site might be dying, you can still lure deer in with water. Art Helin, a Hunter's Specialties pro staffer from southwest Wisconsin, has been struggling with food plots all summer, but his manmade waterholes are attracting bucks daily. He fills them via a water tank on a trailer.
3. Think autumn. As the seasons change, so does the increased chance of precipitation. Plan for a fall food plot. Prepare your area and keep it weed-free. Watch the forecast. Plant when a rain event, especially an extended front, is about to hit. A little bit of green can pull bucks in that are tired of dry browse.
4. Move your stand. If food plots fail, move your stands to greener riparian zones where deer might increasingly be found browsing. Also, scout for mast crops and fruit trees. The deer have been pounding the chokecherries near my home, and the plums are about ready for the taking as well. Acorn trees can also be early season hotspots.
5. Check your laws. If you can bait, set up a bait station. It's events like these that can actually make baiting successful. A top-end food attraction like Buck Natural, a hand-pollinated cross of special strains of corn, can lure-in bucks tired of nipping crispy leaves.
There's no great escape from drought conditions, but you can still find whitetail success with forward-thinking strategies.


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Teen Services
Top 10 Best Books for Teens in 2007
All books are listed in alphabetical order by author. Click here to see if a book is in!
The Astonishing Life of Octavian Nothing, Traitor to the Nation Vol. 1: The Pox Party
by M.T. Anderson
It sounds like a fairy tale. He is a boy dressed in silks and white wigs and given the finest of classical educations. Raised by a group of rational philosophers known only by numbers, the boy and his mother - a princess in exile from a faraway land - are the only persons in their household assigned names. As the boy's regal mother, Cassiopeia, entertains the house scholars with her beauty and wit, young Octavian begins to question the purpose behind his guardians' fanatical studies. Only after he dares to open a forbidden door does he learn the hideous nature of their experiments - and his own chilling role in them.
Samurai Shortstop
by Alan Gratz
Tokyo, 1890. From his first day at boarding school, Toyo Shimada is taken aback when the seniors keep him from trying out for the baseball team - especially after he sees their current shortstop. Toyo isn't afraid to prove himself; He's more troubled by his uncle's recent suicide. Although his uncle's defiant death was supposedly heroic, it has made Toyo question many things about his family's samurai background. As the gulf between father and son grows wider, Toyo searches desperately for a way to prove there is a place for his family's samurai values in modern Japan. Baseball might just be the answer, but will his father ever accept a "Western" game that stands for everything he despises?
by Sonya Hartnett
As life slips away, Gabriel looks back over his brief twenty years, which have been clouded by frustration and humiliation. A small, unforgiving town and distant, punitive parents ensure that he is never allowed to forget the horrific mistake he made as a child. He has only two friends - his dog, Surrender, and the unruly wild boy, Finnigan, a shadowy doppelganger with whom the meek Gabriel once made a boyhood pact. But when a series of arson attacks grips the town, Gabriel realizes how unpredictable and dangerous Finnigan is. As events begin to spiral violently out of control, it becomes devastatingly clear that only the most extreme measures will rid Gabriel of Finnigan for good.
by Patricia McCormick
Lakshmi is a thirteen-year-old girl who lives with her family in a small hut in a mountain village in Nepal. Her life is made up of simple pleasures but these happy times are undercut by the desperate poverty that threatens the lives of the villagers. Then one day, Lakshmi's father brings her to a shopkeeper in town and tells Lakshmi that she is going to go work as a maid in India so that her wages can be sent home. Glad to help support her family, Lakshmi undertakes the long journey and arrives at "Happiness House" full of hope. But she soon discovers the unthinkable truth: she has been sold into prostitution.
Anahita's Woven Riddle
by Meghan Nuttall Sayres
Anahita, a nomad, learns that her father has promised her hand in marriage to a man she dislikes. Determined to have a say in her own fate, Anahita convinces her father to let her hold a contest, in which potential suitors must correctly answer the riddle she has woven into her wedding carpet. A diplomat, a schoolteacher, a shepherd, and a prince compete in Anahita's battle of wits, for the heart of this extraordinary girl.
The Trap
by John Smelcer
Seventeen-year-old Johnny Least-Weasel knows that his grandfather Albert is a stubborn old man and won't stop checking his own traplines even though other men his age stopped doing so years ago. But Albert Least-Weasel has been running traplines in the Alaskan wilderness alone for the past sixty years. Nothing has ever gone wrong on the trail he knows so well.
When Albert doesn't come back from checking his traps, with the temperature steadily plummeting, Johnny must decide quickly whether to trust his grandfather or his own instincts.
The King of Attolia
by Meghan Whalen Turner
By scheming and theft, the Thief of Eddis has become King of Attolia. Eugenides wanted the queen, not the crown, but he finds himself trapped in a web of his own making surrounded by the subtle and dangerous intrigue of the Attolian court. When a naive young guard expresses his contempt for the king in no uncertain terms, he is dragged by Eugenides into the center of the political maelstrom. Like the king, he cannot escape the difficulties he makes for himself but he discovers a reluctant sympathy for Eugenides as he watches the newly crowned king struggle against his fate.
The Rules of Survival
by Nancy Werlin
It all starts when Matthew observes a heroic scene in a convenience store: A man named Murdoch puts himself
between an abusive father and his son. Matt is determined to get to know this man. And when, amazingly,
Murdoch begins dating Matt's mother, it seems as if life may become peaceful for the first time.
Matt and his sisters have never before known a moment of peace in a household ruled by their unpredictable,
vicious mother. And so, after Murdoch inevitably breaks up with her and the short period of family calm is
over, Matt sees that he needs to take action. He refuses to let his family remain at risk. Can he call upon
his hero, Murdoch? And if not, what might his desperation lead him to do?
American Born Chinese
by Gene Luen Yang
Three apparently unrelated tales of a monkey king, a young Asian boy, and a popular football player come together with an unexpected twist, in a modern fable that is hilarious, poignant, and action-packed. American Born Chinese is an amazing ride, all the way up to the astonishing climax.
The Book Thief
by Markus Zusak
Set during World War II in Germany, Markus Zusak's groundbreaking new novel is the story of Liesel Meminger, a foster girl living outside of Munich. Liesel scratches out a meager existence for herself by stealing when she encounters something she can't resist-books. With the help of her accordion-playing foster father, she learns to read and shares her stolen books with her neighbors during bombing raids as well as with the Jewish man hidden in her basement before he is marched to Dachau.


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Gluten in Cosmetics, Lotions, Shampoos, Soaps … Should You Worry?
Categories: All, Gluten Free 101, New Gluten Free Products
Tags: , Bath, Celiac, Cosmetics, Dermatitis Herpetiformis, DeVine, Gluten Free Beauty, Gluten Rash, Hugo Naturals, Kristen Campbell, Lipgloss, Lipstick, Lotion, Topical Gluten
There was quite a stir this week after the annual scientific meeting of the American College of Gastroenterology in Washington, D.C. Why? Because a new study by George Washington University researchers showed not only that gluten is an ingredient in many cosmetics and topical lotions (although they are rarely labeled as containing gluten – a problem), but that using these products may actually exacerbate celiac disease.
The lead author of this study – a professor of medicine at George Washington University – indicates that anyone who is sensitive to gluten could experience a topical reaction. Wow – that is news, because up until now, most physicians had glossed over (pardon the pun) any effects gluten in topical products might have on the body of a celiac or someone with gluten sensitivity. These conclusions are considered preliminary until published in a peer-reviewed journal.
What we do know for sure, is that accidental and inadvertent exposure to gluten can come from using gluten-containing lotions, lipsticks, or other products if the product is used around the mouth. It's also wise to check the gluten-free status of your dental products, like mouthwash and toothpaste (although it's not common). Some household cleaners may contain gluten and pose a threat as well (click here to read an article on gluten-free cleaners).
Dr. Daniel Leffler, director of clinical research for the Celiac Center at Beth Israel Deaconess Medical Center in Boston was interviewed recently for an article on this subject for Allergic Living Magazine. He noted that "There is infinite variability in human disease, too – perhaps other conditions that share similar pathways to celiac disease. 'We diagnose people all the time with conditions that don't have a name or a reason but that doesn't stop us from prescribing a reasonable treatment for it,' he continues. 'That is the bottom line.'"(For more on this investigation and the medical response, read this Allergic Living article)
Whether product reactions could come due to celiac disease, gluten sensitivity or wheat allergy, the real problem all of us gluten-free'ers face is that there is little to no ingredient labeling on cosmetics and other topical lotions and soaps. The George Washington University study authors investigated 10 leading cosmetic companies in the US, and found that only two offered detailed ingredient information, and even those did not indicate whether their products contained gluten.
If you would like to avoid gluten in your cosmetics and skin care products, these are the main ingredients to watch out for: wheat, barley, malt, rye, oat, triticum vulgare, hordeum vulgare, secale cereale and avena sativa.
For more on this topic, I asked Kristen Campbell, gluten intolerant "Skinnovator" of the Gluten Free Beauty skin care and cosmetics line to share her expertise on the subject. Below is Kristen's take on whether and why gluten doesn't belong in your cosmetics, lotions and shampoo, and how to find out whether it is an ingredient. To hear my interview on the subject with Kristen, listen to the free podcast of The Gluten Free Voice with Jules.
Years ago when I read that up to 60% of what we put on our skin is absorbed into the bloodstream, I was a fast convert to natural and organic skin, hair and cosmetic products. If anything was going to be absorbed into my body, I was going to have something to say about it.
Despite my healthy diet and switch to healthier, natural beauty products, however, in the middle of my twenties, I found myself battling horrible, seemingly incurable acne. Oddly enough, it was mostly relegated to my back and chest; a sudden and strange occurrence that even a doctor, an aesthetician, and an acupuncturist could not solve. But then I made the connection to gluten.
After being diagnosed as severely intolerant to gluten, I thought about that 60% and figured I had better raid my bathroom cabinets and drawers, ridding it of all traces of gluten. This was several years ago now, so at the time, there was little information available about gluten in topical products. The few online sources I found blamed Vitamin E Oil, and finding a list of natural and gluten-free products was nearly impossible.
So I started calling the manufacturers. At the time most companies had little clue what gluten was, so I would have to know what I was talking about. Some ingredients were easy to pick out like "hydrolyzed wheat protein," but ingredients like Vitamin E Oil, Lactic Acid and Xanthan Gum which can be derived from various protein sources needed further investigation. And I was surprised by what I learned:
- · Vitamin E Oil is More Often Than Not Gluten-Free: Even a few years ago, most companies were using Vitamin E Oil sourced from corn or soy, not wheat germ oil. I've even tested pure wheat germ oil using an ELISA Tek EZ Gluten Test Kit and had it come out negative. But, would I use a product containing wheat germ oil, still NO.
- · Expect the Unexpected: In food terms I've never heard of Xanthan Gum or Lactic Acid derived from wheat. Usually Xanthan is from corn, and Lactic acid is from beet sugars or dairy. But in the realm of the beauty world, I have come across both sourced from wheat. In a recent news release Dr. Pia Prakash spoke about a patient who was reacting to a gluten-containing lotion, stating that, "celiac patients face a huge challenge in trying to determine whether cosmetic products contain gluten — and a risk of unknowingly exposing themselves to gluten." I find that the easiest way to avoid topical gluten is to use only products with easily understandable ingredients. And if you don't know what something is, ask.
- · What Goes Up Must Come Down: For me, some of the less obvious contributors to my breakouts were my hair products. While gluten can be in any product from a lipstick to a body wash, I would say that more hair products than not contain gluten. When you think about the nature of a hair product, it is actually meant to coat the hair, so when you're showering—especially if you condition your hair last thing–it's all washing right down your face, back, chest and body, coating the skin.
Things are, however, moving in the right direction. Some of those same companies that I was calling a few years ago are already labeling gluten-free hair, skin, nail and cosmetic products as such. I've even called the not-so-natural brands to receive prompt answers to my inquiries about the gluten status of specific products.
But where are the doctors on this? A little behind. Most celiac experts will admit that while medicine tells them that the gluten protein is too large to be absorbed by the skin, their patients are telling them otherwise. And those same doctors are paying attention. In a recent article for Living Without Magazine, renowned celiac expert Dr. Alessio Fasano confirmed the existence of gluten intolerance and sensitivity saying, "The patients, as usual, were visionary, telling us this stuff existed but healthcare professionals were skeptical." So I would say, "Hold tight!" The medical community is still playing catch up, but they are getting there.
Personally, I know that topical gluten affects the body, because I've witnessed it firsthand. After ridding our home of all external (and internal) gluten, my skin cleared right up. If I do have a topical gluten-slip and accidentally apply gluten to my skin, I will still have acne breakouts, or develop a rash on my scalp, but by sticking to gentle, natural product lines with good ingredient labeling, staying topically gluten-free is not too big a challenge.
The subject of gluten in beauty products is a cause that has become close to my heart; going topically gluten-free has improved my health and my life, and I hear from hundreds of men and women each year who are also making the connection between the gluten in their hair, skin and cosmetic products and the challenges they have faced with their skin and health. After years of reviewing natural, gluten-free beauty products, I even decided to create my own gentle, natural line, Gluten Free Beauty to help eliminate some of the guesswork.
–>Kristen Campbell made the connection between topical gluten and her acne, rosacea and skin rashes years ago when she was diagnosed as intolerant to gluten. At the time very little information about gluten in beauty products existed, which led her to start a blog dedicated to the subject. Years later she put all of her research to work and developed Gluten Free Beauty, a gentle, natural, effective skin care and cosmetic line created to help address the skin care needs of the gluten-free community. Kristen was recently named a "Skinnovator" by Prevention Magazine for the development of her innovative beauty line.
If you are interested in more gluten-free brands, here are some others of my favorites:
Red Apple Lipstick: All Red Apple Lipstick products are certified gluten free, paraben free, soy free, dairy free and allergen free. They are also also vegan, natural and cruelty free.
DeVine Lip Shimmers - These girls make some fun lip gloss, and it's not only natural and yummy tasting, it's also packed with antioxidants! Their glosses come in everything from Vanilla to their trademark wine flavors: Champagne, Merlot, Bordeaux and Rosé complete with "tasting notes" on the site!
And I see a new product I might have to try since I sampled my first lip shimmer in September: Rush High Powered Lip Balm with caffeine and B vitamins. Hard to tell what lips pumped up with caffeine might say or do, but it could be fun to try!
26 Comments
We'd love to hear yours!
Liz said: on November 4, 2011
Thank you! Even my husband thinks I am being a bit neurotic about this so it's really nice to hear evidence backing me up! Beauty and makeup products are undergoing a major overhaul in our house!
Keela said: on November 6, 2011
I have noticed feeling unwell after wearing certain lip products and I always breakout after wearing certain hypoallergenic brands of makeup… I never put two and two together. Thank you for the product list.
Jill Ricks said: on November 8, 2011
I love your website! It's very informative and easy to navigate. I work for a company that sells gluten-free lipsticks. We are so confident you'll love our products we offer an exchange program- send us your old lipstick (any brand) and we'll send you one of ours (shipping not included). http://www.redapplelipstick.com/
Thank you for bringing to light the importance of a gluten-free lifestyle. My niece suffers from Celiac disease and I am going to pass your site along to my sister. Thanks! Jill
Jules said: on November 9, 2011
Thanks for sharing that information, Jill! Sounds like a great program – I might have to try that! Now, where did I put that "other" lipstick ….?!
Kasey said: on January 25, 2012
Thank you so much for sharing this information! I have been tested twice now, both showing negative results, but my body cannot handle gluten whatsoever – I get fatigue, weak, achy muscles and severe wringing stomach issues if I have anything containing gluten. Recently, I have developed skin sensitivity to gluten as well (perhaps triggered by severe bout of bronchitis?) I have replaced ALL of my skin care, cosmetics, soaps, and hair care products with certified gluten-free ones. I am now going through some of my "unknowns" trying to figure out if they contain gluten. If you know of any other hidden gluten, please let me know. Again, thank you so much!
Beth Meadows said: on July 9, 2012
Thanks, Jules!! My shampoo and hair products made me as sick as gluten foods. It was a 'silent killer' to this Celiac Sister. Gluten was in everything I used. For new friends: You have to ready EVERY Single LABEL in your life.
Maryellen Callahan said: on October 20, 2012
Hi not only is my nineteen year old daughter gluten insensitive (her brother and grandmother have diagnosed celiac disease) but she is highly allergic to corn, soy, eggs, oats, nuts, apples, oranges, carrots, yeast, milk,cheese and tomatoes. I am having a hard time finding food for her. Rice everything, meat, and potatoes and broccoli is about all she eats. When you are gluten free shopping the gluten is substituted with corn, oats, soy,…Soups have carrots and tomatoes. So if I get her rice noodles or gluten free crusts still no pizza, no spaghetti. Now she showered and broke out in a rash on her neck, chest, face, and ears. So what kind of gluten free shampoos and lotions do not have the fruit above and other allergens above. Do you have any helpful suggestions for us. Thank you so much! Sincerey Maryellen Callahan very sad mom
Jules said: on October 21, 2012
Hi Maryellen – definitely contact GlutenFreeBeauty.com and ask Kristen about her products or recommendations for other shampoos, etc. As for your daughter's other food allergies, I'd strongly suggest you buy or borrow my book from the library: Free for All Cooking. It addresses what to do when you're dealing with gluten AND other food allergies and intolerances. I think you'll find it very helpful in cooking for your daughter. Please let me know if I can be of help in other recipes, as well. That book has a fantastic yeast-free, gluten-free sandwich bread, for example, that will be great for her! All the best to you both!
IrishHeart said: on November 6, 2012
"60% of what we put on our skin is absorbed into the bloodstream"
Can you please provide a Pub Med or scientific journal resource for this fact?
I have never heard this before.
Jules said: on November 7, 2012
Hi Irish Heart, that statistic is part of the quoted interview of Kristen Campbell at GlutenFreeBeauty.com. Please contact her directly via this link to find out more. Thanks for reading!
Jamie said: on December 1, 2012
Hi! I have been using Aveeno Noursih and condition leave in treatment. It contains wheat and gluten.
I recently been diagnosed with celiac and just realized I have also been using this product. I was curious does this effect it? effect my skin? (which is bad) even if its just in my hair? thank you so much.-
Jules said: on December 1, 2012
Jamie – great question. Technically with celiac disease exposure to gluten is only harmful if it is INGESTED (eaten). Many people find, however, that they are sensitive to wheat a gluten topically as well. With products like lip care and toothpaste that go on or in the mouth, it is critical that they be gluten-free, but if you are not reacting to gluten on your skin or hair, then you shouldn't worry too much about that. If your skin is already bad though, you may want to try gluten-free products to see if that helps. Hope that answers your question!
Peggy said: on February 15, 2013
I have heard the exact opposite about vitamin E. It is listed as tocopheryl and tocopheryl acetate in ingredient lists. For example – when I contacted the Body Shop they confirmed that 100% of the tocopheryl they use is wheat based. 9 times out of 10, for me, if I am reacting to a product I find this in the ingredient list.
Ginny said: on May 14, 2013
I have the same allergic reaction to tocopheryl and tocopheryl acetate in facial products. It makes my eyes swell and I have a very dry itchy rash from it.
Rachael said: on March 1, 2013
I have been gluten free now for 2 months and I feel great for the most part! It is amazing what one little thing can do to mess up your whole bodily systems. The last bite of any gluten I have had was 2 weeks ago (one tiny girl scout cookie). Usually I just feel nauseous and I can pretty much go on with my day. But for the last week I haven't been able to figure out what is up with me feeling sick again. This morning I checked my vitamin E cream for no apparent reason and found that it has wheat germ oil. Which led me to my internet search if this could make it into my bloodstream and essentially give me a "gluten attack" as I have been calling it. I am going to quit using it and see if it makes a difference! Thank you for your article!!
Jules said: on March 1, 2013
So glad the article has been helpful to you, Rachael – I hope you feel better soon!
Pilar said: on March 5, 2013
I am just learning about being truly gluten free. This is amazing to be thisinformed. Only 7 days ago I was diagnosed as allergic to gluten. I am happy to have so many options. I feel healthier and educated. Thank you.
Amanda Aswegan said: on June 10, 2013
Arbonne offers products that are certified vegan & gluten free!
Hair care, skin care, baby care, cosmetics, nutritional support (protein shakes, energy drinks, etc.) -
Pamela said: on August 9, 2013
After feeling miserable at times and I couldn't connect it to food, I finally investigated topical possibilities. Sure enough, a new skin care regimen contained gluten. When I stopped it, I immediately felt fine. I found out that all Origins' boxes, not the tubes or bottles, contain the ingredients list. When I called the company, I found that they are very well informed. Better yet, all their products are gluten tested annually. They could tell me which of their products are gluten free.
Jules Shepard said: on August 9, 2013
Great tip to look for Origins brand, Pamela. Thanks!
Barbara S said: on September 15, 2013
Hi, I just got a new bottle of Clinique Dramatically Different Moisturizer. The yellow one that probably millions of women use every day. They have changed the formula and it now contains barley. The older bottle, for which I still have the box, does not. They sent a free sample of dark spot concealer which also contains barley. Just thought I would mention it in case you know of anyone who uses the product.
Jules Shepard said: on September 15, 2013
Thanks so much for the information, Barbara!
Julia said: on February 19, 2014
I have celiac disease. My head and neck have been itching me like crazy. I got checked for lice and definitely didn't have any. I've been using herbal essences honey I'm strong and I'm not sure if it's gluten free. Will non gluten free shampoo cause my head and neck to itch?
Jules Shepard said: on February 19, 2014
Hi Julia, everyone has different sensitivities, so I would definitely switch shampoos and see if it helps. Just because you have celiac disease doesn't mean that your skin will react to topical gluten, but there could be something else in the shampoo (or it could be the gluten) that is causing your skin to react. If no other hair care products are touching your scalp, you haven't changed detergents or any other variables, then I would certainly try that first. I hope it helps!
13. Sep, 2012
[...] This post by Jules Gluten Free about gluten-free cosmetics (featuring an interview by Gluten Free Beauty, Kristen Campbell). Do you react to gluten in cosmetics? Did you know the average woman consumes approximately four pounds of lipstick over a lifetime? [...]
03. Oct, 2013
[…] that can be absorbed in any way into the blood stream. Who knew? I didn't. This blog julesglutenfree.com has great information on topical products, cosmetics and gluten intolerances as well as […]
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Trees knocked down, power knocked out after storms hit region, including Salem
Much of Southwest Virginia was left in the dark Friday night after an evening storm with gusts topping 80mph swept through the area, downing trees and sparking fires.
Between 8:30 and 9:30 p.m., dark clouds blotted the sky after a sunny, record hot day. Within minutes lights inside homes began to flicker, and many lost power altogether.
By 11:30 p.m., at least 50,000 Appalachian Power Co. customers were without electricity across Southwest Virginia, according to spokesman Todd Burns. Nearly 1million were in the dark across its entire service territory, Burns added.
Outage reports continued into the quiet hours of the night.
To read the rest of the Roanoke Times story, click here.
The Salem Red Sox game last night was ended early last night due to high winds and flickering lights – they shared this information in their normal post-game press release:
Salem, VA (June 29, 2012) – Around 9 PM, Manny Rivera was loosening for the top of the eighth inning, with Salem trailing Potomac 4-1, when some of the stadium lights went out and the wind started whistling. As more of the lights dimmed, the wind intensified, and both teams retreated to their dugouts and clubhouses while fans were escorted to the sturdy stairwells and the secure ground level tunnel underneath the main concourse. While Mother Nature displayed her power with winds estimated at around 80 miles per hour, everybody waited, with the game officially being called approximately an hour after the delay began.
We also have some storm damage reports from our Salem friends on Facebook, posted around 11 and 12 p.m. last night, Friday, June 29:
Chris Stevens: Limbs down on Alleghany Drive
Beth Jennings: Lots of trees down in my yard on Mitchell rd near exit 137
Jeff Brunk: Below Karen Hills got rocked Mulberry/Pyrtle area..power lines down on my house, trees fell on cars across the street…I'm sure its bad everywhere.
Heather Gillespie Alvarez: Fireworks tent in front of Salem Walmart is in the road.
Robin Realtor-Atkins: My front porch is terrible, my car is totally muddy from my once hanging plants, heavy grill is totally destroyed,
Zach Ruble: Power line down on Mountview rd. off of Callaway! no power
Sandra Elliott: no power at Salem Village
Tammy Davis Epperly: huge mess at the end of Ross in Salem. I have a huge locust tree down in my backyard. Next door neighbor has hole in roof from limb falling. Will post pics in morning.
If you have damage reports or photos you'd like to share, post to our Facebook page or email us at firstname.lastname@example.com.


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This is some freaky-deaky Star Wars porn by an artist named Miravi. This is the tamest picture I could find, so you can imagine what some of the other stuff is like. Think fully nude hardcore shit that'll burn your corneas out (I can type by touch). So, yeah. There are two more pictures after the jump, and a link to the gallery, which is WAY WAY WAY WAY WAY NSFW. You hear me? You will be fired before you can tell the IT guy "I thought I was being Rick Rolled, I swear!" And on top of being unemployed, you'll be branded perv of the year. But seriously, if anybody actually uses these pictures to, you know, PEW PEW!, make sure to leave a comment so we can all make fun of you. Wait -- actually, don't.
Hit it pervert.
Click this only if you are at home and your wife or girlfriend thinks the computer is a microwave
Thanks to Nathan, who found the pictures strictly by accident.
First of all, these videos are NSFW because they're all of of some chick pleasuring a microphone. Jesus, I feel dirty just posting them. Apparently they're part of some performance piece by artist Wojciech Kosma that has something to do with, um, acoustics, and, uh, bl0wjobs.... / Continue →
Have a mouse problem? Stop leaving cheese out yo. But if you want to get rid of them and feel like a sadistic bastard in one fell swoop, look into the Victor Multi-Kill Electronic Mouse Trap. Basically a mouse walks in, up some stairs, gets his electrocution on in the Shock ... / Continue →
WARNING: NSFW VIDEO IS NSFW This is the highly, highly, HIGHLY NSFW music video for the Flair's 'Truckers Delight'. I can't even begin to describe to you how dirty I felt after watching it. Unless you've ever swam in pig shit and then showered in vomit afterward. In which c... / Continue →


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BMW 3-Series AWD vs. BMW 5-Series AWD
bruceomega Posts: 250
markcincinnati Posts: 5,042In the wings a 335 sedan and in the +1 year from now (or perhaps a bit less) wings, a 335xi sedan and coupe.
As an Audi lover, it seemed a lot like driving an S4 that was at least $7000 less and got better gas mileage.
The 335xi sedan should be a threat to the Audi line up A4/S4 range -- ain't competition great!?! :shades:


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Mathri Recipe
Mathri Recipe | Mathri Recipe in Hindi
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Nimki Recipe
Nimki has a flavor of kalonji and is crispy like namakpaare. It has salty and spicy taste. Serve them with kasundi or green coriander chutney, in both ways you will like its special taste. हिन्दी में
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Besan Pare Recipe
Namak pare made with all purpose flour (maida) are often liked by everyone. If you don't like using maida, then besan pare is what you will like more. Besan pare are made with gram flour and wheat
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Potli Samosa Recipe
Potli samosa are like small packets or bag that look very beautiful, unique and very delicious. Compared to other samosa, potli samosa are very small in size and can be served as starter in any party
13514 Views
Sugar coated Shakarpare Recipe
Shakarpare coated with sugar are very delicious, these can be prepared for any festival or occasion or any other time you want and have them whenever you crave for something time. - Ingredients for
10918 Views
Farsi Puri Recipe
Mathari made in Gujarati Style is called Farsi Puri. It is extremely crispy and can be eaten in the breakfast or as a snack with tea in the evening.I am sure your family members will like this
37237 Views
Dhania Masala Mathari Recipe
Masala Mathari prepared with Coriander leaves is more preferable in taste than any simple Mathari. Simple Mathari is prepared by simply adding Carom Seeds (Ajwain) to it, But this crispy Masala
27768 Views
Corn Flaky Biscuits - Makke ki Mathri Recipe
Corn dishes help in protecting us from cold in winters. Let's make the corn flakes biscuits to eat along with the evening's tea. Ingredients for Corn Flaky Biscuits Corn flour – 500 gm Salt – 1 ½
11868 Views
Makki-Til Sweet Mathri Recipe - Indian Corn flour mathri
Both sesame and corn meal are healthy for winters. We are making corn meal and sesame ki tikki today. Ingredients for Corn-Sesame Tikki Corn meal (Makke ka atta)– 200 grams ( 2 teacups) Jaggery
13410 Views
Maida Papdi
Maida papdi is very crispy and good in taste. You can make papadi at home and store in an air-tight container for a longer period of time and eat with tea or coffee everyday or whenever you like.
19986 Views
Mathri Recipe – Salted Crackers Recipe
Before the trend of Biscuits shot up, home-made Matharis (Flaky Biscuits) were preferred for snacks and treats. Its specialty is that you can make them at home and can be stored for more than a month
32958 Views
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Baltimore's Collection of Collections
Art lovers share an unspoken bond. Standing before a work of art, we are transported. Art takes us beyond our sense of sight; a vivid amethyst evokes the rich scent of wine - a brilliant saffron, the warmth of sunshine. An almost magnetic force arrests us as we take in a drawing or painting or sculpture - our only choice is to stop, look and step inside. So it must have been for the early collectors who created the foundation for Baltimore's thriving art scene; each cultivated an appreciation for beauty, ideas and creativity. For modern-day art enthusiasts, Baltimore's museum collections provide an exciting link to the past. Your half-day tour of museum collections will take you from the Maryland Historical Society and The Walters Art Museum to the Baltimore Museum of Art (BMA).
The artistic legacy of the Peale family is celebrated in museums around the country, but the Maryland Historical Society houses the nation's largest collection of paintings by the creative clan. The 19th-century Baltimore family was known for their artistic tendencies: sons with names like Rubens, Raphaelle and Rembrandt became well-known painters of their time. Charles himself was a portrait painter, as was his brother James. James's daughters Sarah, Anna and Margaretta were painters as well. The Peale Collection at the Maryland Historical Society also boasts an archive including 252 glass plate negatives made in the 1920s, and 133 modern photo prints printed from negatives.
During the time that the prolific Peales were creating art in Baltimore, another local family was finding its artistic footing in a different way. Born in 1819, William Thompson Walters was a Pennsylvania native who arrived in Baltimore in his early twenties. Two decades later, having become a successful merchant, Walters turned his attention to collecting art. Walters patronized local artists in Maryland, and after moving his family to Paris, France, he continued to patronize contemporary French artists such as Jéan-Leon Gérôme, Honoré Daumier and Antoine-Louis Barye. Walters' son, Henry, shared his father's passion for collecting and, as a young man, stood in for his father at international art exhibitions. Years later, after his father's death, Henry developed a vision for a museum that would fulfill an educational role within the local community. Today, The Walters is acclaimed as one of the best art museums in the United States, featuring art and artifacts which span more than 5,000 years of history and the globe.
At the turn of the 20th century, the art scene in Baltimore would find two more allies whose influence would be felt for decades to come. The Cone sisters, Claribel and Etta, were members of Baltimore nobility-educated, cultured and well-traveled. The sisters had very different tastes: Etta was the younger, more conservative sister, and Claribel, more open to the avant-garde. By the time the sisters were in their thirties, they had become friends with writer Gertrude Stein and her brother Leo, and through them, joined an exciting creative community of writers, musicians and artists. The sisters made annual trips to Europe to purchase fine art for their stately Bolton Hill apartments. In 1906, Etta met French painter Henri Matisse during a visit to Paris. Over the course of Matisse's career, the sisters collected paintings, sculptures, drawings, prints and illustrated books from the artist. Thanks to the Cone sisters, Baltimore has the world's largest collection of works by Henri Matisse with unmatched holdings of more than 600 works of art.
The Cone Collection is a must-see for art lovers visiting Baltimore. In addition to the works of Matisse, the internationally renowned collection features works by Paul Cézanne, Paul Gauguin, and Vincent van Gogh, as well as a variety of textiles, jewelry, furniture, and African, Asian, and Near Eastern art.
Many sites require groups to make advanced reservations for tours and visits. Please contact each site before your group tour.
Plan your trip!
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