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Rohnert Park Party on the Plaza
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Tonight from 7p-8p catch E-Town's show with Judy Collins & Shawn Colvin. Part 1 of 2. Conversation and music!
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text:
black n white with color Black & White
Artist description:
No description entered.
Created Jun 25, 2012. Unless noted Copyright 2012
sistercool .
We encourage you to submit a comment and let the artist know what you think of this drawing. Please log in or join to post a comment.
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wow, i love this! the symmetry, the contrast and the hart they make! great drawing!
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subset: commoncrawl


text:
Cedars West serves Cedars tennis resort with lawsuit
Date: November 4, 2009
by: Robin Hartill | Community Editor
Cedars West of Longboat Inc. filed a lawsuit against Cedars Tennis and Fitness Club Inc., seeking damages in excess of $15,000. The dispute is over two hard-surface tennis courts located across the street from Cedars West condominium, 5655 Gulf of Mexico Drive.
The lawsuit, filed Friday, Oct. 23, in the Manatee County Courthouse, states that the tennis club took over the courts "by strong arm without the consent of Cedars West."
According to the lawsuit, Cedars West had exclusive rights to the courts as the result of a 1981 agreement with Hunt Building Corp., the predecessor in title to Cedars Tennis and Fitness Club.
The lawsuit states: "The Agreement further provided that it could only be terminated by Cedars West, its successor or assigns relinquished its rights in writing or if Cedars West constructively abandoned the Tennis Courts by failing to maintain and repair the tennis courts, nets and fencing in a manner substantially equivalent to its then existing condition."
An Aug. 14 report from the Longboat Key Police Department stated that Cedars West Manager Patricia Bell called police after Randy Langley, president of Cedars Tennis and Fitness Club, delivered a letter to the condominium stating that residents no longer had rights to the two tennis courts. The letter said that Cedars West's failure to maintain and repair the courts, nets and fencing amounted to "constructive abandonment."
The letter stated: "There are new locks on the gates. Your right to the courts is hereby terminated and your presence on the courts will be considered trespassing."
The lawsuit states that shortly after Langley purchased the tennis club in May 2008, he "demanded of Cedars West management that (Cedars Tennis and Fitness Club) have joint use of the tennis courts with Cedars West, as (Cedars Tennis and Fitness Club) had need for hard surface courts for its tennis club."
Langley said he could not comment on the lawsuit.
According to Andre Perron, of the Bradenton law firm Ozark, Perron & Nelson, which represents Cedars West, the two parties initially entered into negotiations, but he is unable to comment on the negotiations. But he said that at the time Langley assumed control of the tennis courts, Cedars West had a contract with Lawson Courts Inc. to make repairs.
"In any event, we deemed the courts playable," Perron said.
Perron said that Langley has continued to use the courts without making any substantial repairs of which Cedars West owners are aware.
A temporary-injunction hearing is scheduled for 2:45 p.m. Friday, Nov. 6, at the Manatee County Courthouse.
Contact Robin Hartill at email@example.com
Currently 0 Responses
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March 10: The great debate
The Observer will hold a debate for Longboat Key Town Commission candidates at 7 p.m. March 10, at Bayfront Park Recreation Center, 4052 Gulf of Mexico Drive. -
Greg Hoffman SCOREs award
Longboat Key resident Greg Hoffman received Manasota SCORE's Platinum Leadership Award at the organization's 50th anniversary awards luncheon Feb. 24. -
Spring forward for Daylight Saving
Daylight Saving Time begins Sunday, so turn your clocks forward by an hour before bedtime Saturday night.


text:
I hope that this story will encourage others to consider adopting an older dog. My 14-year-old Lab/Chessie mix (an AHS alum) had passed away, and after a period of mourning, I decided that I needed a dog in my life again. I really enjoyed my dog's "golden years" and decided to adopt an older dog. It was my lucky day when I found Gunner, a 10-year-old lab on the Animal Humane Society website. She had lived with dogs, cats, kids, the whole 9 yards, but had lost her home to foreclosure! It was pretty much love at first sight as far as I was concerned. And she REALLY wanted to get out of the shelter and go to a new home. With a new name (she is Sunny now) and a new little "pack" that includes two very welcoming and laid-back cats (also AHS alums) she is very, VERY much at home a year and a half later. I am so happy to have found her, and I have no doubt that she is thrilled to have found us. I deeply appreciate the sacrifice that her first family made in giving her up. They raised a wonderful dog, and I am the beneficiary of their love and labor. You would never guess that this girl is now going on 12!
Patrice E.
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text:
New User - Guitar Effects
I have taken several months since getting reasons essentials to get all the hardware setup and have kind of figured out how to navigate around. The set up was pretty smooth. But as I didn't know anything about using an actual mixer before I bought Reason Essentionals with a Balance interface. So after getting the software going, I realized it's really not the right software if you didn't know anyting about mixers before hand. But now we're here. And the mic works and the midi keyboard works; and the guitar kind of works, in that a signal goes in and comes out and sounds like the guitar. No buttons in the FX section of the mixer affect the sound of the guitar. I've watched all the tutorials and looked at the documentation. What combination of the very very many buttons in the mixer causes the sound of the guitar to change? It's extremely frustrating as everything seems to go according to the book, except the sound does not chaange. Thanks. Paul
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text:
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Chamber retains interim board
Published on Wed, Mar 26, 2008 by
Anna Lillian Moser
Read More
A special meeting of the Sequim-Dungeness Valley Chamber of Commerce on March 20 set the stage for a stronger organization.
Close to 150 chamber members packed the Guy Cole Convention Center after a group calling themselves the Concerned Chamber Committee called on the chamber president to set the special meeting.
Although there were several agenda items, the key purpose was to vote on removing the interim board and replacing it with an entirely new board.
Walt Schubert, who recently stepped up as interim board president, chaired the meeting that began with a vote to amend the bylaws in order to be able to remove the board members with a two-thirds majority vote.
Interim board vice president Mike McAleer admitted the bylaws needed to be revised after several in the audience remarked they hadnt been updated for several years.
Our bylaws are far from perfect, McAleer said.
McAleer noted when he was chamber president in 2004 the bylaws didnt get updated as they should have.
We have conflicts with the RCWs. Theres certainly nothing that in our bylaws that deals with what occurred on Feb. 12, McAleer said, referring to the chamber meeting that ended with the resignation of 11 board members after the board fired executive director Lee Lawrence.
The change to the bylaws passed 133-20.
The second agenda item called for approval to allow a special election that would take place only once.
This is just for tonight, Schubert told the membership.
The motion passed 143-9, laying the groundwork for the third item, the removal of the standing board members who included Hattie Dixon, Ron Gilles, Annette Hanson, Deborah Rambo Sinn and McAleer. Schubert and Irrigation Festival representative Jean Wyatt were excluded from the vote.
Robin Ferre, co-owner of Latte 101 and a member of the CCC, made the motion to remove the interim board members.
Do you really want to remove them? asked chamber volunteer Esther Nelson. Does everybody want to get rid of some good people?
Another chamber member asked what the board did to deserve removal.
Its not so much what they did, its what they didnt do, said Ron Ferre, co- owner of Latte 101 and co-chairman of the CCC.
Larry McHugh, a former board director, called the meeting the dumbest, most ridiculous meeting Ive ever seen.
After more discussion, the vote was taken, with members in good standing checking a yes or no box and placing ballots into cardboard boxes for validation by an impartial election judge, Sequim Bible Church pastor Dave Wiitala.
The resolution to remove the board failed, with 69 voting for removal and 84 voting to keep the board.
There is not a two-thirds majority, so the existing board exists, Schubert said after the votes were counted.
The board now has seven vacancies to fill. Rambo Sinn read 21 nominees for the vacancies. Any further nominations may be sent to Rambo Sinn by March 30.
Elections will take place in early April, she said. A committee to review nominees has been appointed by Schubert.
McAleer said he would resign shortly after a new board has been seated, which was his plan from the beginning.
Byron Nelson, former Sequim Police chief, thanked Schubert and the present board from a grateful community.
In turn, real estate broker Linda French asked for a round of applause for the CCC for demanding more accountability from the chamber board.
We cant just close our eyes and pretend nothing happened, French said.
As for hiring a new executive director, Schubert said that would not happen until a full board is seated.
It wouldnt be fair to hire a director without a board, he said.
Schubert told the group he will step down as soon as the new board is commissioned.
I want to be done by the end of May, he said.
Schubert also is gathering a bylaws committee that will report back to the board 30 days after the review of the bylaws is complete.
Its not an easy thing to do, Schubert said of rewriting bylaws.
The meeting adjourned at 8 p.m., much more quickly than many thought when arriving at 6 p.m.
Hattie Dixon breathed a sigh of relief when the gavel closed the meeting at 8 p.m.
This is a good first step, Dixon said, fielding congratulatory remarks from chamber members.
But there are still challenges ahead.
The 21 current nominees for positions on the board are Dale Barrell, Ron Bell, Arturo Briseno, John Carson, Scott Clausen, Jacques Dulin, Robin Ferre, Ron Ferre, Dorothy Gonzalez, Allen Grant, Liz Beth Harper, Linda Harvey, Bill Head, Bill Humphrey, Damien Humphrey, Charles Martin, Sandy Placek, John Rosaschi, Gil Simon, Kevin Wall and Emily Westcott.
Chamber members have until March 30 to petition (signed by 10 chamber members in good standing) for additional nominees. Send petitions to Deborah Rambo Sinn c/o Olympic Music School, P.O. Box 2796, Sequim WA 98382, or deliver to a lockbox at 319 1/2 W. Bell St.
Ballots for the upcoming election will be sent by mail to all chamber members after April 1. Members are instructed to cast their ballots and return them by mail.
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Nature's Best
by Tina Shake
Related Articles |
Getting Rid of Roaches
Natural Roach Remedy Natural Insect Repellents |
I am a natural woman. You know the kind. I am the one with the flowing natural blonde curls standing on a breezy hillside chasing the butterflies through the prairie grass. I am woman, hear me roar. Okay, I am a middle-aged grandmother that wears sweatpants that are two sizes too small. I lug around a snot-nosed grandchild on one hip and I am usually swatting at various insects and pests with the new book that my daughter Petunia checked out in the library. I am learning natural pest control.
This book said that if I was serious about getting rid of the flies and other pests that I should carefully read each chapter. I did read every chapter. One chapter was about the flies; it said that bats eat over 3,000 insects per night! Bats! Now that is a great answer to a big problem. I could let the bats eat the flies at night while we were sleeping. When I get up the next morning, my home would be fly-free! Petunia and I got little Eugene tucked into his car seat and proceeded to a rural farm store in search of bat houses. I figured if they were going to work so hard for me, the least I could do is provided them a comfy place to sleep during the day. I set up the houses outside and it wasn't long before the houses had their little occupants living inside. Yes, you could watch them at night swooping around the security light. Now I want you to learn from my mistakes. Please do not sneak the bat houses into your house. A bat in the house is a bad idea, and yes, it is messy. Your little darlings will die of starvation, as they need lots of flies to live on. Not that I tried doing that.
Flies and mosquitoes do not like basil. Fix up a few muslin bags with basil inside to keep them away. Put the bags in inconspicuous places. If you hang too many bags, your dinner guest might be a little too curious. Don't have the bags in the same areas as the bats, again the bats will starve. Not that I tried doing that.
Now, sometime in your life, you will have to deal with a cockroach. Cockroaches hitch hike in your home through very innocent means. Some come in from the grocery store hidden in your sack of potatoes or in the paper bags. Now I am not saying that I have cockroaches in my home. That stampeding sound when you turn the lights on in the kitchen at night could just be your imagination. Anyway, the book said to place a shallow dish of cheap wine under the sink. The cockroaches drink the wine and you find them later on their backs with their little feet sticking straight up in the air. A little tip from me to you. There is no need to sample the cheap wine. You do not need to buy an assortment of wine for this purpose. Not that I tried doing that.
My pet poodle, Killer, brought a flea into the house this past summer. I do not like fleas. Dinner parties can be ruined by fleas. Do not try to make the best of things by trying to start a flea circus. (Fleas, contrary to popular belief, are hard to train.) Anyway, according to the library book, fleas do not like the scent of brewer's yeast and garlic. You could put out this concoction in small containers around the house. Do not attempt to make carpet sprinkles out of yeast and garlic. This does not smell like Glade. Not that I tried doing that.
Rodents among other things are rats and mice. Do you remember the cartoon "Tom and Jerry"? My mice were nothing like Jerry. My mice don't have a cute little house in a hole in the wall. Mine are nasty. I mean I have heard that they are nasty because I haven't really ever had a mouse problem. If I did have a mouse problem, I would know that rodents do not like oil of peppermint. You can find oil of peppermint at your drug store and other department stores. It is used to make candy, but in this case, just put a little on a cotton ball and place them in the areas that have shown evidence of rodent visits. Candy canes do not work. Do not leave leftover candy canes throughout your home. Not that I tried doing that.
I thought that I would pass on this wisdom to you all because I can just imagine what it would be like to have a nasty pest problem like yours. Of course, when you keep a house as clean as mine, you rarely see a......
"Eugene, that is not a pet! No, no! Petunia get the wine! No, it is underneath the bat house! Oh drat that candy cane is stuck to the bottom of my slipper. There it goes, it is underneath the couch!"Share your thoughts about this article with the editor: Click Here
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Luck ready for new version of old offense NFL The Score
July 12, 2013, 05:36:48 AM »
He's ready to get started.
INDIANAPOLIS (AP) Andrew Luck can't wait to get back to work, even though he knows it won't be the same.
Of course, Luck was the star attraction.
While some young quarterbacks struggle to adapt to major offensive changes, Luck has a built-in advantage. He worked with Hamilton at Stanford and ran a similar offense with the Cardinal, so he already knows the concepts and the playbook.
Before getting back to football,
adidas jeremy scott
, though, Luck was taking care of other business in Indianapolis - launching ``Change The Play,
jeremy scott adidas wings
,'' a campaign intended to help children stay active and make healthy nutritional choices. Luck is working through Riley Hospital for Children and spent two hours Saturday going through exercises with about 50 kids at the Indiana University Health Sports Performance center.
``I took some time off, relaxed, worked on Change The Play and got back to work,'' he said.
And when he gets back to the office this week, there will be plenty to do.
It starts with learning a new offense. Instead of relying on Arians' vertical passing game, new offensive coordinator Pep Hamilton will implement his version of the West Coast offense with a power running game.
On Monday, the veterans will be streaming into the team's west side complex for their first team meeting of the 2013 season.
``I think we've all been chomping at the bit since the last game,'' Luck said, referring to January's playoff loss at Baltimore. ``It's nice to be back in town and seeing the guys trickle in.''
There's at least one player Luck does not intend to mentor: Reggie Wayne.
``I think it's the Colts offense, but it will be good,'' Luck said when asked about comparing it to the Stanford offense. ``I'm excited to get to work with him (Hamilton). I think it will be good to not have to learn a whole new thing.''
``I'd like to go to a Super Bowl, but it's going to take a lot of work,'' he said. ``We need to make sure we get to the team meeting on time Monday, first.''
But all Luck really wants to do this season is change the final chapter.
The Colts' locker room will have plenty of new names and faces. Bruce Arians isn't around, so Indy's second-year quarterback will be working with a new offensive coordinator. Instead of wondering where he'll be playing in the fall or completing classes to earn his architectural degree, Luck can spend the entire offseason working with his teammates.
Luck brought along several teammates including running back Vick Ballard, left tackle Anthony Castonzo, defensive tackle Josh Chapman and receiver Griff Whalen. Also attending were IndyCar driver Charlie Kimball, who has a weekend off from racing, and Juergen Sommer, a Indiana University alum who was an American goalkeeper on two World Cup teams in the 1990s.
He wasn't alone.
The upside of the change is that the Colts will have at least three players -- Luck,
jeremy scott leopard shoes
, Coby Fleener and Whalen, all Stanford alums -- around to help teach their NFL teammates how it works.
``Reggie's too smart, he doesn't need me teaching him anything,'' Luck said.
Here, he's an emerging NFL star.
Last season, Luck produced one of the best rookie seasons ever by a quarterback. He orchestrated one of the greatest one-year turnarounds in NFL history, as the Colts improved from 2-14 in 2011 to 11-5 and made a shocking return to the playoffs. He also set NFL rookie records for attempts (627) and yards passing (4,374) and most yards passing in a single game (433), broke Peyton Manning's franchise rookie mark for completions (354) and finished third all-time among rookies with 23 TD passes. Afterward, he earned a trip to the Pro Bowl, where he teamed up with Manning on the AFC team.
So how does a high-profile quarterback spend his first pro offseason,
``What sport would I play if I couldn't play football? I'd love to play soccer,'' he said when one of the children asked. ``I grew up in Europe, so soccer was a big sport over there.''
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RuntimeMethodHandle Structure
.NET Framework 4.5
RuntimeMethodHandle is a handle to the internal metadata representation of a method.
Namespace: System
Assembly: mscorlib (in mscorlib.dll)
The RuntimeMethodHandle type exposes the following members.
Name | Description | |
Equals(Object) | Indicates whether this instance is equal to a specified object. (Overrides ValueType.Equals(Object).) In XNA Framework, this member is overridden by Equals(Object). | |
Equals(RuntimeMethodHandle) | Indicates whether this instance is equal to a specified RuntimeMethodHandle. | |
GetFunctionPointer | Obtains a pointer to the method represented by this instance. | |
GetHashCode | Returns the hash code for this instance. (Overrides ValueType.GetHashCode().) In XNA Framework, this member is overridden by GetHashCode(). | |
GetObjectData | Populates a SerializationInfo with the data necessary to deserialize the field represented by this instance. | |
GetType | Gets the Type of the current instance. (Inherited from Object.) | |
ToString | Returns the fully qualified type name of this instance. (Inherited from ValueType.) In XNA Framework 3.0, this member is inherited from Object.ToString(). |
Name | Description | |
Equality | Indicates whether two instances of RuntimeMethodHandle are equal. | |
Inequality | Indicates whether two instances of RuntimeMethodHandle are not equal. |
Windows 8.1, Windows Server 2012 R2, Windows 8, Windows Server 2012, Windows 7, Windows Vista SP2, Windows Server 2008 (Server Core Role not supported), Windows Server 2008 R2 (Server Core Role supported with SP1 or later; Itanium not supported)
The .NET Framework does not support all versions of every platform. For a list of the supported versions, see .NET Framework System Requirements.


text:
Forums → Popular Media
Posted Sep 19, '12 at 11:11pm
12,058 posts
There aren't very many movies out there that make me laugh hysterically every time I watch them, but Weekend at Bernie's is a rare case of endless hilarity for me.
Have you seen this movie? If you have not, I recommend it to anyone who can appreciate comedy and real humor. It truly is a classic, and there really aren't any movies out there that are anything like it.
Well, except for Weekend at Bernie's 2...
Discuss the movie. What do you think of this comedic masterpiece (and perhaps its sequel)?
Posted Sep 20, '12 at 12:25am
9,740 posts
Yup, I've seen it many times. You might think that the dead guy will start to smell eventually.
Posted Sep 20, '12 at 7:44pm
You might think that the dead guy will start to smell eventually.
He does, actually, in Weekend at Bernie's 2.
Posted Sep 20, '12 at 9:30pm
1,180 posts
I did see the first one a number of years ago, but I don't remember much about it because I was probably about 15 or 16 at the time... I do remember it having some good laughs, though... I'll have to watch it again soon of course to make sure!
I didn't know they made a sequel! I'll have to check that one out too if I can find it anywhere... =)
Posted Oct 19, '12 at 6:51pm
461 posts
o wait thats that movie i saw when these guys came to a rich persons house and he died for some reason and they had a party in his house and he was dead the whole time its been awhile since i seen it but it kinda was like that?
Posted Oct 19, '12 at 10:20pm
I'll have to watch it again soon of course to make sure!
You will laugh until you die. Then you'll start dancing to Caribbean music.
You'll understand when you watch both movies.
That's Weekend at Bernie's, in a nutshell, but it's a lot funnier than it sounds. And it sounds pretty hilarious as it is.
You must be logged in to post a reply!


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For the thirty-third year, Ruston will be hosting one of north Louisiana's most popular outdoors events, the Sportsman's Jamboree.
Spawned back in 1980, the initial meeting was held at the Ruston Civic Center with a gathering of a few dozen hunters and property owners who met to discuss topics related to hunter safety but the main focus was on letting property owners know how valuable they are to hunters for making their acreage available for hunters to use, mostly free of charge; that was before the advent of hunting leases in north Louisiana.
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Mon February 25, 2013
Mo. House panel to consider Medicaid expansion
Proponents of a Medicaid expansion will get their say at the Missouri Capitol — even if they don't get their way.
A House committee is scheduled to hear testimony Monday on a Democratic proposal to expand eligibility for the Medicaid health care program to an estimated 260,000 additional lower-income adults. The plan has the support of Gov. Jay Nixon and is called for by President Barack Obama's health care law.
But the Republican-led Legislature has generally opposed the Medicaid expansion.
The Democrats' bill is not expected to pass. But Republican Rep. Jay Barnes, who is chairman of the committee, plans to introduce his own Medicaid proposal.
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BeerAdvocate on your phone?! True story. Try the beta now.
Tickets for American Craft Beer Fest are on sale now! (May 30 & 31 in Boston, MA)
Bison Organic Gingerbread Ale - Bison Brewing
Displayed for educational use only; do not reuse. |
Ratings: 245 | Reviews: 143 | Show All Ratings:
Reviews by athouve1:
More User Reviews:
3.5/5 rDev +2.9%
look: 3.5 | smell: 3.5 | taste: 3.5 | feel: 3.5 | overall: 3.5
I'll cut to the chase, this is a disappointing beer, especially for the price.
It pours nice and dark with very little head. The aroma is faintly spiced and barely beer-like.
The taste is light and crisp, beer-like with a nice hint of spice. It is a subtle, balanced flavor. The aftertaste is nice and it makes for a mildly interesting burp.
This brew is pretty tame and subtle. It is not a good value and I will avoid it in the future.
Serving type: bottle
02-27-2014 23:42:58 | More by schoolboy
4.11/5 rDev +20.9%
look: 4 | smell: 4 | taste: 4.25 | feel: 4 | overall: 4
A: Pours dark brown, almost black in the glass with a tan/light mocha head.
S: Ginger, cloves, nutmeg and coffee in a delicious smelling nose. Interesting.
T: Lighter fruits, citrus peels, then ginger and nutmeg, maybe cloves, then coffee, biscuit and finally floral and citric hops in the finish.
M: Medium bodied and a bit smooth.
O: It's what you might expect from a gingerbread stout, minus the roasty flavors. It's pretty good, but it would likely benefit from the admixture of roasted malt.
Serving type: bottle
02-08-2014 06:08:17 | More by BierJager89
South Carolina
3.68/5 rDev +8.2%
look: 3.5 | smell: 4 | taste: 3.5 | feel: 3.75 | overall: 3.75
12 oz bottle. Poured very dark brown with a semi-durable beige head.
Aroma: excellent balance in a blend of porter and gingerbread.
Flavor: not so balanced as the aroma, but richer and with more ginger. Also a touch of spicy hops. Lingering bready malt and ginger flavor.
Feel: medium body and carbonation; lively; enough ginger to add to the feel.
O: good but may improve with a little aging.
Serving type: bottle
01-27-2014 16:45:50 | More by chinchill
3.19/5 rDev -6.2%
look: 3.25 | smell: 2.75 | taste: 3.5 | feel: 3.5 | overall: 2.75
I'm a fan of pumpkin beers and that's what this beer reminded me of, since gingerbread and pumpkin spice contain some of the same spices. In actuality, this beer didn't remind me enough gingerbread. I did enjoy the lightness of the beer but if it was a bit creamier or had more of a ginger flavor, I think I would have enjoyed it better.
Serving type: bottle
01-22-2014 00:39:31 | More by iheartmyTHO
4.24/5 rDev +24.7%
look: 4.5 | smell: 4.25 | taste: 4.25 | feel: 4 | overall: 4.25
12 oz bottle poured into Sam Adams Perfect Pint Glass.
A: Nice Dark brown, pretty clear with a good 2 fingers worth of creamy off white head with fantastic lacing from start to finish.
S: I'm getting a lot of ginger spice aromas, very much like a freshly baked ginger bread cookie. There is also a little cinnamon in the aroma.
T: A lot like the smell here.... Gingerbread cookie with nutmeg, cinnamon and a light touch of chocolate. There is also a nice roasted malt running underneath everything.
M: Medium bodied with good carbonation, pretty smooth with a clean finish and a little warming feeling
D: A very nice holiday beer, great flavors good ABV. Perfect for the season, well worth looking for.
Serving type: bottle
01-06-2014 01:06:19 | More by mralphabet
South Carolina
3.15/5 rDev -7.4%
look: 3.5 | smell: 3.25 | taste: 3 | feel: 3.25 | overall: 3.25
Pours an opaque dark brown with a massive head that laces and retains very well. Nose is like a weak porter with ginger added. Some hint of dark malts is present, but very subdued. The body barely makes it past the light category. Very well carbonated, which helps bring forth what flavor is there. Like the nose, dark malt flavor is subdued resulting in a profile that is mostly ginger. While not overpowering, it is rather mild, the ginger needs to be balanced with a background malt flavor profile. The finish is somewhat crisp with a residual weak ginger astringency. Not a bad beer, but it could be improved upon.
Serving type: bottle
12-21-2013 18:09:57 | More by tillmac62
Bison Organic Gingerbread Ale from Bison Brewing
out of 100
based on 245 ratings.


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NEWSLETTERS Free Newsletters Archive My Subscriptions NEWS News by Subject News by Disease News by Date PLoS Search News Post Your News JoVE CAREER NETWORK Job Seeker Login Most Recent Jobs Browse Biotech Jobs Search Jobs Post Resume Career Fairs Career Resources For Employers HOTBEDS Regional News US & Canada Biotech Bay Biotech Beach Genetown Pharm Country BioCapital BioMidwest Bio NC BioForest Southern Pharm BioCanada East US Device Europe Asia DIVERSITY INVESTOR Market Summary News IPOs PROFILES Company Profiles START UPS Companies Events INTELLIGENCE Research Store INDUSTRY EVENTS Biotech Events Post an Event RESOURCES Real Estate Business Opportunities
"Inhibrx has developed an antibody with strong pre-clinical study results on a highly validated target with very promising therapeutic potential," said Tom Daniel, M.D., President of Research and Early Development for Celgene Corporation.
"We are pleased to have a company of Celgene's caliber as the licensee of this program. On a global basis, Celgene has the science, clinical, regulatory and commercial expertise as well as the commitment to patients that continue to deliver disease-altering solutions to patients in need as quickly as possible," stated Mark Lappe, CEO of Inhibrx.
The total deal potential is in excess of $500M. This includes upfront, clinical and regulatory milestone payments. Additionally, Inhibrx is eligible to receive royalties on commercial sales.
About Celgene
Celgene Corporation, headquartered in Summit, New Jersey, is an integrated global biopharmaceutical company engaged in the discovery, development and commercialization of novel therapies for the treatment of cancer and inflammatory diseases through gene and protein regulation. For more information, please visit http://www.celgene.com.
About Inhibrx
Inhibrx is a biotherapeutic discovery and development company, with an extensive internally developed pipeline. Active programs are focused on cancer, inflammatory and metabolic diseases. Inhibrx's programs are based on comprehensive target discovery and selection expertise coupled to the creative implementation of multiple antibody and biologic development strategies for therapeutic lead generation, selection, functional enhancement and optimization. For more information, please visit http://www.inhibrx.com.
Inhibrx LLC:
Mark Lappe, 858-759-1499
Chief Executive Officer


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50. Miley Cyrus tweets holiday photos with her doggy on December 25.
52. Vanessa Bryant, wife of Kobe Bryant attends the Los Angeles Lakers Vs New York Knicks Basketball Game at the Staples Center in Los Angeles, CA on December 25.
Hot Photos Of December 29th
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Adorable White House dog Bo Obama steals the show as Michelle Obama reads 'Twas The Night Before Christmas'. The First Lady was reading the Christmas classic to sick children at Children's National Medical Center in Washington D.C. when Portuguese Water Dog Bo leapt onto her lap and commanded her attention. Photo: Splash News
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A Family Affair!The Duke and Duchess of Cambridge attended Christmas Carols at St Marks Church, Englefield, Berkshire. Prince William and Kate, were accompanied by the Middleton family. Michael, Carole, Pippa and James who sat together in the Church. Photo: Splash News
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My Sanford Chart allows you secure online access to your personal health information and your child's health information. It's available anywhere you have internet access. There is no cost to you and registering is quick and simple.
There are many myths about Tourette's disorder (TD).
Myth | Truth |
"Everyone who has Tourette's disorder uses obscene words and gestures." |
Most people who have the condition do not have this symptom. |
"People who have Tourette's disorder often 'blow up' and get very angry." |
People who have Tourette's disorder are no more likely to blow up than other people. But some people with TD who also have attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), or an anxiety disorder may be more likely than others to have strong emotional reactions to stress. |
"Adults who have Tourette's disorder drink or have problems with substance abuse." |
Like many adults, people who have Tourette's disorder may drink or use drugs. But this type of behavior is not a cause or a direct effect of the condition. |
"People who have Tourette's disorder can control their tics if they really want to." |
Some people who have Tourette's disorder are able to control their tics for short periods of time, but eventually they need to allow the tics to occur. With treatment, people who have TD can learn the warning signs of tics and take steps to prevent them. |
"People who have Tourette's disorder live restricted lives." |
Most people who have Tourette's disorder live normal lives. |
"Intelligence is affected in people who have Tourette's disorder." |
Tourette's disorder does not lower a person's intelligence. |
By | Healthwise Staff |
Primary Medical Reviewer | John Pope, MD - Pediatrics |
Specialist Medical Reviewer | Karin M. Lindholm, DO - Neurology |
Last Revised | July 22, 2013 |
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Research shows that #music does all kinds of great things for kids. http://t.co/oq8zjJkkDC #SanfordChildrens 01:50 PM Feb 25 |


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Stirring the Fire: A Global Movement to Empower Women and Girls
Monday May 06
Showcases the work of photographer Phil Borges.
Where: Fred Jones Jr. Museum of Art
Phone: 325-3272
Address: 555 Elm
Website: ou.edu/fjjma
Showcases the work of photographer Phil Borges.
The University of Oklahoma University Theatre in conjunction with the OU School of Music will present G. F. Handel's opera&nbs ...
Offering significant awards and support to artists, the Oklahoma Visual Arts Coalition's (OVAC) Art 365 exhibition challen ...
One of Oklahoma's beloved artists is getting statewide appreciation during the centennial of his birth. Allan Houser Drawings: ...


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Funding opportunities
Osteosarcoma stem cell-targeted therapy using novel retinoid agonist
Funding Type:
Disease Team Therapy Planning I
Grant Number:
Funds requested:
$110 000
Funding Recommendations:
Grant approved:
Public Abstract:
Treatment of osteosarcoma by targeting osteosarcoam stem cells
Osteosarcoma is the most common type of cancer that arises in the bone and occurs mainly in teenagers and young adults. There are approximately 900 patients diagnosed each year with this disease in the US. Approximately 80% of patients are diagnosed with localized disease while the remaining has either spread to the lungs (most common) and rarely to other bones. Osteosarcoma is treated with surgery and chemotherapy. With this treatment, about 65 out of every 100 patients diagnosed with localized disease are cured. Survival rates have not changed for this disease over the last 3 decades. Moreover, those who relapse or who are diagnosed with metastatic disease have a very poor prognosis where only 10-20 out of every 100 patients survive. Therefore, new treatments are urgently needed to improve treatment and survival for patients with osteosarcoma. One such treatment approach is to change the programming of cancer cells to make them behave more like normal cells-a process called differentiation. Retinoic acid and its derivatives (called retinoids) are agents that are used to cause differentiation of cancer cells in a variety of cancers.
It is believed that "cancer stem cells" give rise to cancer. These cells are also thought to be responsible for resisting treatment and causing relapse that often leads to death. Only few of the cells in the tumor are "cancer stem cells". Recent scientific data strongly suggest that cancer chemotherapy kills the majority of cells in a tumor but the "cancer stem cells" that are within the tumor escape and survive, leading to relapse.
In the laboratory, we have identified a population of cells from osteosarcoma that have "stem cell" properties and call the osteosarcoma-initiating cells (OSIC). These cells can initiate osteosarcoma and cause tumors to grow rapidly when injected into mice that lack immune systems. OSIC have a receptor that can be targeted by retinoic acid that causes differentiation. A synthetic form of retinoic acid called Am80 that is much more powerful and binds more specifically to this receptor on OSIC is now available. By being more specific, it has fewer side effects when compared to retinoic acid. When used in the laboratory, it caused regression of osteosarcoma tumors that were created in immune deficient mice transplanted with OSIC-enriched cells. AM80 is approved for use in Acute Promyelocytic Leukemia (APL) in Japan and is already in clinical trials in the US for patients with APL and lung cancer. AM80 drug supply that is ready for use for treatment of patients is available. We propose to conduct a clinical trial in children, adolescents, and young adults with certain solid tumors that may respond to retinoids and specifically develop OSIC-targeted therapy with AM80 that will benefit patients with osteosarcoma.
Statement of Benefit to California:
Effective treatment of cancers with the least amount of toxicity will result better overall health and an improvement in productivity and is desirable. Standard treatment approaches for most cancers include surgery, radiation and chemotherapy. These result in significant suffering and decreased quality of life. Cancer stem cells are believed to be responsible for cancer initiation as well as resistance to treatment that results in relapse of the disease and death. Targeting cancer stem cells may lead to eliminating cancer and decreasing resistance to treatment resulting in more cures. Targeted therapy being more specific in action will result in fewer and less severe side effects leading to better quality of life and social contribution.
Approximately 134,000 Californians were anticipated to be diagnosed with cancer in 2010 and 55,000 would die from some form of the disease (www.cdph.ca.gov). 1800 Californians are less than 20 years of age are diagnosed with cancer each year. Over the last two decades, the incidence of cancer has decreased by 15% for men and 9% for women in California. Simultaneously, the death rate decreased by 24% for men and 19% for women. It is estimated that there are 1.2 million individuals living in California today were diagnosed with cancer at some time point. California has the lowest lung cancer rates in the country and this can be attributed to successful tobacco control efforts. However cancer continues to be a leading cause of death and hospitalization resulting in significant health care costs as well as lost working days.
AM80 is a drug that belongs to a family of drugs called retinoids and targets cancer stem cells in osteosarcoma, which is the most common bone cancer. It changes the cancer stem cells to make them more like normal cells thereby decreasing cancer formation and progression. Osteosarcoma occurs mainly in children, adolescents and young adults and has a cure rate of approximately 65%. This survival rate has not improved in the past 3 decades. Moreover, the survival of osteosarcoma patients who have advanced disease or who relapse is dismal with less than 20% of patients surviving two years. Treatment with AM80 may improve survival in osteosarcoma patients with fewer side effects. Since osteosarcoma occurs in young individuals, this will result in the maximum number of person-years saved by curing cancer. Additionally, AM80 will likely have broader applicability and show efficacy in other cancers such as lung cancer, ovarian cancer, certain skin cancers, bladder cancer, sarcomas, and several other childhood cancers. Since this clinical trial will be primarily conducted in California, our State's economy stands to gain from the number of person-years that can be potentially saved as well as result in improved quality of life. Additionally, scientific insight gained from this innovative trial may further the biotech industry and lead to new discoveries.
Review Summary:
Project synopsis
The applicant seeks to develop a clinical trial examining the activity of the retinoid Am80 in osteosarcoma (OS), a bone tumor. Am80 is thought to induce the differentiation of putative cancer stem cells, the OS initiating cells (OSICs), thereby eliminating their tumor initiating potential. Am80 is already approved for clinical use in Japan for acute promyelocytic leukemia (APL), and is currently undergoing clinical testing in the US in APL as well as lung cancer. Am80 was designed to display improved target specificity when compared to a related compound, all-trans retinoic acid (ATRA), and may alleviate toxicities associated with the latter agent. The applicant aims to file an investigational new drug (IND) application, conduct a phase I trial and initiate a phase II study.
Significance and Impact
- While two-thirds of OS patients are cured by standard approaches including surgery, radiation and chemotherapy, some patients, especially those with advanced or relapsed disease, have a high mortality rate. Agents that improve clinical outcomes for those patients would be significant.
- It is unclear whether Am80 has the potential for an improved toxicity profile over ATRA in the targeted OS patients. Patients with APL who are treated with ATRA rarely show the skin and other toxicities noted by the applicant, and toxicities associated with a condition known as retinoic acid syndrome would not be seen with either ATRA or Am80 in patients with solid tumors.
- The proposal to study a single agent, Am80, to target cancer stem cells (OSICs) qualifies as an eligible therapeutic approach under this RFA. However, it is unclear whether OSICs are responsible for cancer relapse or progression in OS, since the preclinical data provided in the application were based on the analysis of a single OS cell line.
- Responsiveness to the RFA is questionable since the selectivity of Am80 for putative OSICs has not been clearly demonstrated.
Project Rationale and Feasibility
- Reviewers felt that significant therapeutic responses to Am80 are unlikely based on previous clinical experience with retinoic acid-related compounds. Data to support the role of any retinoic acid-related agonists, such as ATRA, for the treatment of any relapsed refractory adult or pediatric sarcoma would have helped to alleviate this concern.
- One reviewer thought that given the anti-OS activity of Am80 in the preclinical studies, a clinical trial using this agent is warranted.
- The in vivo efficacy data for Am80 is not particularly convincing, since the studies rely on the use of a human OS cell line. Furthermore, the anti-tumor activity of Am80 appears to be only modestly increased compared to ATRA.
- Since Am80 is already approved for the treatment of APL in Japan and is currently undergoing clinical testing in the US for several indications, a clinical trial utilizing this agent in OS is certainly achievable.
- Extensive pharmacokinetic (PK) data is available for Am80 in several animal models and in humans from the APL study in Japan. It is thus unclear why additional PK studies, as proposed, are needed
- The applicant did not justify the selected age range for the phase II study subjects, and the endpoints demonstrating efficacy, especially against OSICs, are not well defined.
Principal Investigator (PI) and Planning Leader
- The Principal Investigator has carried out the preclinical studies leading to the proposal, and is an experienced translational investigator, but has minimal experience in advancing molecules to the clinic or in carrying out clinical trials.
- The Planning Leader is an experienced clinical pediatric hematologist and oncologist, who has been involved in numerous clinical trials and is well suited to carry out the planning proposal.