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Cysteine Residues in the Nucleotide Binding Domains Regulate the Conductance State of CFTR Channels Biophysical Journal, Volume 82, Issue 3, 1 March 2002, Pages 1278-1292 Melissa A. Harrington and Ron R. Kopito Abstract Gating of cystic fibrosis transmembrane conductance regulator (CFTR) channels requires intermolecular or interdomain interactions, but the exact nature and physiological significance of those interactions remains uncertain. Subconductance states of the channel may result from alterations in interactions among domains, and studying mutant channels enriched for a single conductance type may elucidate those interactions. Analysis of CFTR channels in inside-out patches revealed that mutation of cysteine residues in NBD1 and NBD2 affects the frequency of channel opening to the full-size versus a 3-pS subconductance. Mutating cysteines in NBD1 resulted in channels that open almost exclusively to the 3-pS subconductance, while mutations of cysteines in NBD2 decreased the frequency of subconductance openings. Wild-type channels open to both size conductances and make fast transitions between them within a single open burst. Full-size and subconductance openings of both mutant and wild-type channels are similarly activated by ATP and phosphorylation. However, the different size conductances open very differently in the presence of a nonhydrolyzable ATP analog, with subconductance openings significantly shortened by ATPγS, while full-size channels are locked open. In wild-type channels, reducing conditions increase the frequency and decrease the open time of subconductance channels, while oxidizing conditions decrease the frequency of subconductance openings. In contrast, in the cysteine mutants studied, altering redox potential has little effect on gating of the subconductance. Abstract | Full Text | PDF (920 kb) |
Comparing the Temperature-Dependent Conductance of the Two Structurally Similar E. coli Porins OmpC and OmpF Biophysical Journal, Volume 98, Issue 9, 5 May 2010, Pages 1830-1839 István Biró, Soroosh Pezeshki, Helge Weingart, Mathias Winterhalter and Ulrich Kleinekathöfer Abstract The temperature-dependent ion conductance of OmpC, a major outer membrane channel of Escherichia coli, is predicted using all-atom molecular dynamics simulations and experimentally verified. To generalize previous results, OmpC is compared to its structural homolog OmpF at different KCl concentrations, pH values, and a broad temperature range. At low salt concentrations and up to room temperature, the molecular modeling predicts the experimental conductance accurately. At high salt concentrations above 1 M KCl and above room temperature, the simulations underestimate the conductance. Moreover, the temperature dependence of the channel conductance is different from that of the bulk, both in experiment and simulation, indicating a strong contribution of surface effects to the ion conductance. With respect to OmpC, subconductance levels can be observed in experiments only. Subconductance and gating levels can be clearly distinguished by their differences in conductance values and temperature-dependent behavior. With increasing temperature, the probability of a subconductance state to occur, increases, while the dwell time is decreased. The open probability, frequency, and dwell time of such states is largely pH- and KCl concentration-independent, while their amplitudes show a lower increase with increasing salt concentration than gating amplitudes. Voltage dependence of subconductance has been found to be negligible within the uncertainty of the measurements. Abstract | Full Text | PDF (679 kb) |
Block of the Ryanodine Receptor Channel by Neomycin Is Relieved at High Holding Potentials Biophysical Journal, Volume 82, Issue 4, 1 April 2002, Pages 1953-1963 Fiona Mead and Alan J. Williams Abstract In this study we have investigated the actions of the aminoglycoside antibiotic neomycin on K+ conductance in the purified sheep cardiac sarcoplasmic reticulum (SR) calcium-release channel (RyR). Neomycin induces a concentration- and voltage-dependent partial block from both the cytosolic and luminal faces of the channel. Blocking parameters for cytosolic and luminal block are markedly different. Neomycin has a greater affinity for the luminal site of interaction than the cytosolic site: zero-voltage dissociation constants (Kb(0)) are respectively 210.20±22.80 and 589.70±184.00nM for luminal and cytosolic block. However, neomycin also exhibits voltage-dependent relief of block at holding potentials >+60mV when applied to the cytosolic face and a similar phenomenon may occur with luminal neomycin at high negative holding potentials. These observations indicate that, under appropriate conditions, neomycin is capable of passing through the RyR channel. Abstract | Full Text | PDF (255 kb) |
Copyright © 1989 The Biophysical Society All rights reserved.
Biophysical Journal, Volume 56, Issue 4, 795-806, 1 October 1989
Research Article
G.J. Strecker and M.B. Jackson
Department of Physiology, University of California, Los Angeles 90024–1601.
The curare-induced subconductance state of the nicotinic acetylcholine receptor (AChR) of mouse skeletal muscle was examined using the patch-clamp technique. Two mechanisms for the generation of subconductance states were considered. One of these mechanisms entails allosteric induction of a distinct channel conformation through the binding of curare to the agonist binding site. The other mechanism entails the binding of curare to a different site on the protein. Occupation of this site would then limit the flow of ions through the channel. The voltage dependence and concentration dependence of subconductance state kinetics are consistent with curare binding to a site within the channel. The first order rate constant for binding is 1.2 X 10(6) M-1s-1 at 0 mV, and increases e-fold per 118 mV of membrane hyperpolarization. The rate of curare dissociation from this site is 1.9 X 10(2)s-1 at 0 mV, and decreases e-fold per 95 mV hyperpolarization. The equilibrium constant is 1.4 X 10(-4) M at 0 mV, and decreases e-fold per 55 mV hyperpolarization. This voltage dependence suggests that the fraction of the transmembrane potential traversed by curare in binding to this site is 0.46 or 0.23, depending on whether one assumes that one or both charges of curare sense the electric field. Successive reduction and alkylation of the AChR agonist binding sites with dithiothreitol (DTT) and N-ethyl maleimide (NEM), a treatment which results in the loss of responsiveness of the AChR to agonists, produced no change in curare-induced subconductance events, despite the fact that after this treatment most of the channel openings occurred spontaneously. Mixtures of high concentrations of carbamylcholine (CCh) with a low concentration of curare, which produce channel openings gated predominantly by CCH, resulted in subconductance state kinetics similar to those seen in curare alone at the same concentration. Thus displacement by CCh of curare from the agonist binding sites does not prevent curare from inducing subconductances. The results presented here support the hypothesis that curare induces subconductance states by binding to a site on the receptor other than the agonist binding sites, possibly within the channel pore. It is the occupation of this site by curare that limits the flow of ions through an otherwise fully opened channel.


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Tom Bartel
Figurative Ceramic Sculpture Workshop & Demo
Art Department Ceramics Studio - Todd Hall Room 113
Wednesday, April 3rd from 8:30 a.m. - 11:30 a.m. & 1:30 p.m. - 4:30 p.m.
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"Blue Fertility Figure",
Ceramic, 2011, 20" X 12" X 10"
"Party Bust",
Ceramic, 24" X 18" X 12"
Artist Statement:
"The figure has been a potent symbol and charged subject since antiquity, and continues to be an appropriate vehicle to ask some of life's most challenging questions. I believe creating images of or depictions about ourselves can be attributed to a primal need to ensure we survive or to simply tell important stories about what it means to be human. As a result, I am confident that this subject will continue to hold our interest for a very long time.
My work takes cues from a "shotgun blast" of influences ranging from antiquity to popular culture and is constructed to refer to both the body and also charged, stylized, surrogates for the body such as dolls, toys, and figurines. The questions that arise from this cultural mishmash fuel my creative practice. I am interested in both the fragmentation and simplification of human form, especially how this decision encourages, if not requires, the viewer to participate with the work. Within this context, I view that which is absent as significant as that which is present. Furthermore, I use the human condition as a point of departure where themes related to gender, rites of passage, fertility and mortality are constant "threads" within my creative practice.
I see our skin as having the same story-telling potential as the ceramic surfaces I develop. Ultimately, I view these "marks" as having the capacity to be both formally beautiful and to suggest changes that have taken place over time. Surface patterns are also used to blur the line between where clothing ends and skin begins, where the concepts of mask, identity, disguise, and transformation are fundamental to my concerns. Throughout our life our appearance slowly and inevitably changes; in the process our skin records this story."
Tom Bartel Biography
Tom Bartel grew up on the Erie shores of Cleveland, Ohio and is known for his disturbing and humorous fragmented figures that take cues from a "shotgun blast" of influences ranging from antiquity to popular culture. He received his BFA from Kent State University and his MFA from Indiana University-Bloomington.
Tom has lectured, conducted workshops and exhibited extensively throughout the United States and internationally. His work is included in numerous public and private collections and he has received Individual Artist Fellowships from the Pennsylvania arts council, the Kentucky Arts Council and the Ohio Arts Council.
He has numerous publications to his credit, including American Craft, Ceramics Monthly, Clay Times, Ceramics Art and Perception as well as many other periodicals and books.
Bartel currently holds the position of Associate Professor of Art at Ohio University in Athens, Ohio.
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Looking to improve your career and technical education competency or refine your instructional or administrative skills? That's exactly what you can achieve with our master's degree program in Career and Technical education. Previous teaching experience is not required. The strength of this program is that it enables career and technical instructors in allied health, business, home economics, and technical education at secondary and postsecondary levels, as well as industrial training and development personnel, to attain an advanced education by building on your previous training and occupational experience.
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Rated 3,7 out of 5 by 140
Rated 5 out of 5 by DavidZeng Nice and Kind Staff
Compared to the SPG tier 4 Needham Sheraton, although this property only got tier 2. It has better room, better staff, better lounge food ( even better than NYC and Seattle Sheraton). And the Staff was really really nice. Just like SPG standard. I will recommend this one for Boston suburban stay. And this property got free parking lot and free Internet.
11 de marzo de 2014
Rated 5 out of 5 by ESiregar Great service
Lovely hotel with warm superb service.
18 de diciembre de 2013
Rated 5 out of 5 by jk78621 Excellent Staff and Hotel amenities
excellent place to indulge in family activities and fun at the BSC club.
11 de diciembre de 2013
Rated 5 out of 5 by Dash Rowing Club goes to Boston
I had 4 rooms for my grandaughter's Rowing Club from John Carroll University. They had a great stay and were well treated by a great staff. Hope we will return next yearfor this event.
Best regards, Dean Dashner
22 de octubre de 2013
Rated 5 out of 5 by BluedogTraveler Club Level worth it
Stayed at the Boston Colonial and one night we were got the complimentary upgrade to the Club level (on a Sun night). The Club level is so much nicer. Bigger room, tasty evening snacks (hot/cold), good/acceptable breakfast. The Boston Colonial North is conveniently located right off the freeway and there is a nice selection of restaurants within 10-15 min drive. We took the 1 down to the airport and we were surprised what a fast drive it was (within 30 min). You also get access to the health club next door but we didn't have time for that but it looked nice.
1 de octubre de 2013
Rated 5 out of 5 by Lloyd101 This hotel had wonderful staff
Form the moment that I arrived at the hotel and was checked in by Jenny (working at the front desk) I was greeted pleasantly by all staff during my entire stay. I upgraded to the club floor and was pleased at how quiet the room was. I did not hear any noise from adjoining rooms nor from other guests in the hall. I was disappointed in the food selection offered in the club lounge. It was by far the poorest selection I had ever seen being offered in a club lounge. I don't think it was worth cost of the upgrade as I didn't feel I got my money's worth.
12 de septiembre de 2013
Rated 5 out of 5 by krb6 great value
College move-in weekend can be crazy in Boston. But this hotel is very reasonable and highway access is great. Received excellent service from the staff. Also enjoyed the adjacent sports club -- just wish the operating hours were longer.
3 de septiembre de 2013
Rated 5 out of 5 by MikeyG327 just WOW
I recently achieved my platinum status - not only did the staff go above and beyond by recognizing me at check in with multiple "check-in amenities" as I shared I wasn't having a great day. the recognition I received was unbelievable. I truly felt recognized and like a valued memeber for my continued loyalty.
1 de septiembre de 2013


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This photo is awaiting approval and will be posted soon.
Play our fun game and find out if the one you like likes you back. Confide in us if you think you'd hit it off by clicking: Yes, No, or Maybe. We'll anonymously find out and let you know if the feeling is mutual. You have nothing to lose!
You've already said YES! If the feeling is mutual, we'll let you both know.
You've already said No. If you've changed your mind, let us know. If you say Yes, we'll anonymously find out if the feeling is mutual. You have nothing to lose!
You've already said Maybe. If you've changed your mind, let us know. If you say Yes, we'll anonymously find out if the feeling is mutual. You have nothing to lose!
You both said YES! The feeling is mutual. Now the rest is up to you! Say Hi and get the conversation started.
"Sephardic from the bottom now we're here"............... ........Ok, back to the usual profile business. It seems today, that all you see, is violence in movies and sex on TV. Where are those good ol fashioned values, on which we used to rely (trumpet part). Lucky there's the Jdate guy. Lucky there's a dude who, won' t date you and confuse you, cause that will probably make you, mad and cry. He's...the...Jdate.. ..guyyyyyy. (Stewie) I say, what the deuce are you doing? (JDguy) I am writing a profile Stewie, you have any suggestions? (Brian)I do, why don't you remove that hat, it's probably scaring the ladies (JDguy) Nah, it's not like I wear it out in public or anything (Quagmire) Hey, you want to borrow my leopard bathrobe and pose in it, heh heh, I bet you would giggety giggety get some replies. (JDguy) Leopard? ummm nope. (Quagmire)Suit yourself, chicks dig the leopard, aaaaalright. (Mort Goldman) Oh this profile is too long, it is hurting my retinas. (Tom Tucker) This just in, Jdate guy just got IMed. Her exact words...... "hi" What do you make of this Diane? (Diane) Not sure Tom, but it sounds like she is shy. (Tom Tucker) We now go live to Ollie Williams with today's Jdate forecast...(Ollie Williams) It's cold!!!! (Tom Tucker) Thanks Ollie. In another breaking story, pigs that refuse to eat jews? Stay tuned. (Peter Griffin) Bon Jovi everyone. What's going on? (Brian) Jdate guy is trying to finish writing this profile. (Peter) Ooh ooh, say that you like to Zumba, eat tofu, and quote Shakespeare on a daily basis. (JDguy) But I don't. (Peter) Heheheheh, wuss. (Stewie) Oh for goodness sake, all of you imbeciles are giving me a headache. Leave the room at once so I can plan my world domination. (Lois) Aww I think Stewie needs a nap (Stewie) Silence you contempible shrew or I shall wreak havoc on you and your tupperware. JDguy, you wretched bench pressing Jew, end this profile at once. (JDguy) Ok, ok...sheesh.


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The Pocket Shark: Not Mightier Than A Sword, But Could Still Put An Attacker's Eye Out
The Pocket Shark is a $7 pen that doubles as a weapon thanks to its rugged construction.
For starters, it's made from the glass-reinforced plastic, Grivory, the same tough material we use in our NIGHTSHADE SERIES (of knives), and features walls that are 4 times thicker than similar markers. This means it's built for impact and, in a self-defense emergency it can become an efficient Yawara stick for driving off an attacker. Plus, the screw-top cap will stay in place and won't pop off like a regular marker's cap would when you strike a percussion blow, or when obtaining joint locks or submission holds.
ZOMG! One minute I'm thinking, "yes, that marker does looks sturdy", and next thing you know they're talking about "percussion blows" and "submission holds". Well, I guess as long as the cap doesn't come off while I'm braining some poor sap. Hey, Superficial Writer -- come check out this pen trick I just learned!
UPDATE: Jesus, who the hell brings nunchucks to work?
Pocket Shark Isn't Your Average Marker [ohgizmo]
Thanks to Mikey, who may or may not be a pocket pool shark.
Well folks, it's finally happened: mechanical pencils and markers are breeding. What's next, paperclip/staple orgies? NOT IN MY DESK DRAWER! Haha, like I have a desk! Sharpie has combined the permanence of a pen with the erasability of a pencil with their new Liquid Pencil.... / Continue →
Let's face it, at one time or another we've all wanted to get stabby on a coworker. Sometimes the feeling is fleeting, but usually it's something we think about doing constantly and doodle pictures of. Enter the $20 Campco TacPen (the Tac stands for tactical, not taco, which ... / Continue →
First of all, thank you all for the kind birthday wishes. I just went through and read them all and that was some seriously sweet shit you all said (I'm so eloquent). I almost cried, but then I wrestled a bear (and won) so that I wouldn't. But seriously -- thanks, I had the... / Continue →


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Wabasha-Kellogg Chamber and CVB
- 137 W Main St, PO Box 105, Wabasha, MN 55981 | Get Directions
- Phone: 651-565-4158
- Toll Free: 800-565-4158
- Fax: 651-565-2808
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- Visit Website
Add to my trip
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Year-RoundWabasha is the oldest city on the entire upper Mississippi River and has been occupied continuously since 1826. Our city was named in honor of an Indian Chief of the Sioux Nation, Chief Wa-pa-shaw.
Wabasha's historic district has more than 50 buildings listed on the National Register of Historical Places. Take our historic walking tour and discover the stories that have made this town so unique.
Hospitality has been a Wabasha trait. Wabasha dishes up generous hospitality to all kinds of guests with four seasons of exciting fun. Visitors enjoy outdoor activities, including eagle watching, artistic experiences, unique shopping, fine dining and lodging to fit every taste and budget.
The Wabasha-Kellogg Area Chamber of Commerce and Convention and Visitors Bureau is open 8:00am - 5:00pm Monday - Friday, Saturday 9:00am - 3:00pm except Holidays, closed Sunday. We are located at 137 West Main Street in historical downtown Wabasha.
Other Date Information
- Additional Date Information: Open Monday thru Friday 8:00 am - 5:00 pm, Saturday 9:00 am - 3:00 pm Closed Holidays.
- Soar With the Eagles Package
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1/6/2014 - 3/31/2014 - National Eagle Center & Lark Toys Getaway
1/6/2014 - 12/31/2014 - Wabasha Romance Package
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3/1/2014 - 12/31/2014 - Sail Lake Pepin Getaway
5/1/2014 - 11/1/2014


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CHARLESTON, W.Va. - Count inspirational rapping among the talents of Antonio Easley.
Antonio is an 11-year-old fifth-grader at Watts Elementary School on Charleston's West Side, where he serves as student council president. He was the school Math Field Day representative and maintains a 4.5 grade point average.
"My favorite classes are math and reading," he said. "Math will help me in life and so will reading. Biographies are my favorite. I like to learn about new people. They interest me."
Principal Pam Gould said Antonio will be missed as he moves on to middle school. She said he even made a presentation to the Kanawha County Board of Education on behalf of the school improvement council.
Add to his many interests basketball, football, playing drums and writing his own lyrics for rapping.
He said he likes to perform as a rapper as a way of inspiring other kids to use their individual talents in bold ways.
He steers away from those already written lyrics that promote drugs and inappropriate behavior. Instead, his songs inspire others to make the most of life and do homework to achieve good grades.
"I try to get kids who are nervous to show their talent," he said. "I believe everyone has a talent no matter what they say."
Antonio will be among performers at the Salvation Army's Boys & Girls Club End of School Block Party 11 a.m. to 2 p.m. Saturday at 301 Tennessee Ave.
The annual event encourages adults to spend meaningful time with children.
The block party will include food, prizes and many activities for parents and their children, ages 6 to 18. There will be a free tech-style hip-hop class, chess tournament, contests, games inflatables, face painting and vendor tables.
Some of the activities include concert performances by the Coyotes in Boxes, Elevation Ministry and Antonio, a member of the Charleston club whose stage name is Mr. Eazy.


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Image Number: 0519-1001-1622-2238
President Barack Obama and First Lady Michelle Obama welcome visitors to the White House in the Blue Room. 1/21/09.
This free, public domain photograph may not be used in materials, advertisements, products, or promotions that in any way suggest approval or endorsement of the President of the United States, the First Family, the White House or any persons appearing in the photos. Stock photography by White House Public Domain.
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director of choral music / assistant professor of music
Shepherd joined Catawba from Concord University in Athens, West Virginia, where he served during the 2011-2012 academic year as assistant professor and director of choral and vocal music. He also served from 2006 until 2011 as associate professor and director of choral and vocal music at Austin Community College in Austin, Texas.
Shepherd earned his Bachelor of Music degree in Music Education and his Master of Music in Choral Conducting from Morehead State University in Morehead, Kentucky. He holds his Doctor of Musical Arts in Choral Conducting from the University of Texas in Austin, Texas.
He is active in professional organizations including American Choral Directors Association, College Music Society, Music Educators National Conference (NafME), Phi Mu Alpha Sinfonia, Texas Choral Directors Association, Texas Music Educators Association, West Virginia Choral Directors Association, and the National Collegiate Choral Organization, of which he is an inaugural member.
Shepherd's goal at Catawba is to "foster artistic, self-sufficient musicians." He values "the privilege of education" and plans "to continue inspiring music educators and performers through the choral art."
What is your particular interest in your field? Why?
Growing up in rural east Kentucky, my uncles "picked and sang" bluegrass music more than they drank, which is saying a lot. And while my loving mother is borderline tone def, she began buying me classical, country, and even rap music cassette tapes as soon as I began school. I joined the band in middle school and later the choir in high school and it changed my life. While attending a music festival at my local university in Kentucky, I fell in love with the idea of going to college to become a music teacher. After being the first to graduate high school in my family's history, I did just that. My biggest interest in music is fostering a love for high level music making through the same type of inspirational and meaningful rehearsals and performances that changed my life.
What is one thing that no one knows about you but you wish they did?
That I chose a music scholarship in college over an athletic scholarship (tennis).
If you could be someone else who would it be and why?
Stephen Sondheim. He's the greatest musical theatre genius ever, in my opinion.
Share a couple of items that are on your bucket list:
To see a baseball game in all 30 major league stadiums (5 to go). To visit the Baltic nations. To conduct all the choral works of Estonian composer Arvo Pärt.
What is your biggest pet peeve?
People who text during movies. I am the text police.
If you could only have one thing to eat, what would it be?
BBQ ribs
Share a word or a phrase that best describes you:


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Loves Park, IL (August 27, 2010) Residents of Loves Park and Machesney Park can receive two for one admission at Rockford Speedway this Saturday, with proof of residency. The nights events will include the Beatin' N' Bashin' Boat Race, Stanley Steemer NASCAR Late Models, Bargain Hunter Sportsman, Budweiser American Short Trackers, Mtn Dew RoadRunners, American Super Cups, plus Fan/Driver Egg Toss, and the Kids Mini Grand Prix.
The Mtn Dew RoadRunner division is packed with local drivers, from Loves Park there's Jason Van Hise, Joshua Lundy, Anthony Lloyd and Linnea Lundy, and from Machesney Park there's "Hotrod" Lloyd Hawkins, Jason Brockway, Kyle Watts, Mike Wallis and "Gentleman" Gene Marocco. Marocco is coming off of a second place finish from last weeks RoadRunner feature, the veteran driver proves age is just a number.
American Short Tracker driver Rachel Sparkman of Loves Park will be battling it out against her uncle, BJ Sparkman of Machesney Park. BJ is coming off of a third place finish in last weeks feature. Rachel is only the second woman to win an American Short Tracker Feature in the history of the division.
The racing action will begin at 7:07, General Adult Admission is $10, General Kids Admission for those ages six to 11 is $5 and kids five and under are admitted free. For more information on any 2010 season event please visit www.rockfordspeedway.com or call 815-633-1500.
This article was posted to the website on August 27th, 2010


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Land of Songs
Aldona Watts Five grandmothers in a Lithuanian village are the last in a long line of traditional folk singers, whose songs have survived centuries of war and occupation. Today, most young people are not continuing this oral tradition. As one granddaughter learns about the village's troubled past, she discovers the importance of her grandmother's songs as chronicles of history, agents of political action, and deep expressions of mourning, healing, and joy. But is it too late? | When making a fiscal sponsorship donation with a credit card, 3% is deducted from the donation amount to cover the merchant account processing fees. This deduction is waived when donating with a check. Checks can be made out to "San Francisco Film Society" and mailed to: San Francisco Film Society ATTN: Finance Dept. 39 Mesa St. Suite 110 San Francisco, CA 94129 Please indicate "FSP 1452" in the memo of the check. |


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Christopher B. LeFevre of Delta died Dec. 17, 2011, at his home. He was 39.
A memorial service will be held Saturday, Jan. 7, at 2 p.m. at Taylor Funeral Service Chapel in Delta.
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BeerAdvocate on your phone?! True story. Try the beta now.
Tickets for American Craft Beer Fest are on sale now! (May 30 & 31 in Boston, MA)
Route 113 I.P.A. - Sly Fox Brewing Company
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New Hampshire
3.59/5 rDev -3.8%
look: 3.75 | smell: 3.75 | taste: 3.5 | feel: 3.25 | overall: 3.75
Appearance - Cloudy, burnt orange with a two-finger width, light tan, soft/frothy head. Head slowly disappears and leaves lacing all the way around the glass.
Aroma - Combination of caramel sweetness and floral/resinous hop flavors.
Taste - Similar to the smell with the caramel sweetness and the floral hops.
Mouthfeel - A very, very bitter IPA that almost numbs the tongue. Slight carbonation. Some stickiness to go along with the overpowering bitterness.
Overall - First beer from Sly Fox. Didn't have any real expectations going into it other than knowing it would be a bitter IPA at 113 IBUs. The bitterness of the beer just overpowered all the flavors/aromas which took away from my overall perception of the beer.
Serving type: can
01-21-2014 18:07:20 | More by ChrisL24481
3.65/5 rDev -2.1%
look: 3.5 | smell: 4 | taste: 3.5 | feel: 3.5 | overall: 3.75
Six pack from Giant Eagle $9.99
Undated can at 40 degrees into goblet
Aroma piney
Head average (3 cm), off white, frothy, mostly lasting
Body dark orange, hazy
Flavor begins with a piney bitterness, no malt, no alcohol, no diacetyl
Ends with a light chalky astringency
Palate medium, slight oilyness, carbonation lively
I've had this on draft, in bombers, and in cans. It's a nice, go-to IPA, easy drinking.
Serving type: can
01-18-2014 15:34:10 | More by Ozzylizard
Route 113 I.P.A. from Sly Fox Brewing Company
out of 100
based on 341 ratings.


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Theory of Nuclear Fission
Nicolas Schunck,
Lawrence Livermore National Laboratory (LLNL)
Wednesday, January 30, 4:10 PM - Nuclear Science Seminar
NSCL Lecture Hall
The mechanism of nuclear fission has been used successfully for several decades in practical applications such as energy production. However, most of these applications rely on powerful semi-phenomenological models finely tuned to specific data, and the connections between these models and the underlying nuclear interactions within the atomic nucleus remain somewhat unclear. In many areas of basic nuclear science where fission plays a major role, such as, e.g., the stability of superheavy elements, or the formation of elements in nuclear capture processes (fission recycling), experimental data is scarce at best, very often unavailable. A predictive theory of fission, which would firmly root the dynamic of the fission process and the properties of the fission fragments into the theory of nuclear interactions, would, therefore, prove invaluable. The Lawrence Livermore National Laboratory has started such a comprehensive program on nuclear fission theory a few years ago. The laboratory is also a key player in large global US efforts, such as the SciDAC 2 UNEDF and SciDAC 3 NUCLEI programs, which aim at achieving a better understanding of nuclear structure by combining our best knowledge of the nuclear force, high-performance computing and applied mathematics. Our framework to describe fission is the nuclear energy density functional theory (DFT) and large amplitude collective dynamics, and it is very dependent on the growing field of computational nuclear physics on leadership class computers. After a historical reminder, specific challenges and selected advances in the field will be reviewed. In particular, special attention will be put to the quantum mechanics of the scission point (when the nucleus finally splits in two) and the impact of high-performance computing in large-scale DFT calculations.


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Government Identity
The federal government has several ID card programs underway. At the same time, states have been redesigning their driver's licenses. If improperly designed and implemented, these initiatives could facilitate undue government and private sector tracking of individuals. CDT advocates for technical and legal safeguards for ID information.
Follow the latest CDT news with Press Releases, Events, and where we've been featured around the Internet.
Name | Issues | Date |
PASS ID Act Offers REAL Reforms Blog Post: Today legislation was introduced in Congress to provide a much needed overhaul of the REAL ID... |
6/15/2009 | |
CDT Supports Privacy Protections Proposed in the PASS ID Bill Press Release: Washington--The Center for Democracy... |
6/15/2009 | |
Bill Would Rein In Laptop Searches at the Border Statement: Random, intrusive searches of the contents of laptop computers at the border would be outlawed by... |
Border Searches | 9/29/2008 |
Leslie Harris, A Technology Agenda for the Next Administration, The Huffington Post, Sept. 29, 2008 Commentary: It's taken a little less than eight years to demolish the Constitutional balance between security... |
9/29/2008 | |
CDT Policy Post: Security and Privacy Issues Associated With Federal RFID-Enabled Documents Statement: CDT issued a policy post today addressing security and privacy issues associated with federal RFID-... |
7/25/2008 |
Find all our latest Policy Posts (Policy Posts are in-depth analyses on current tech policy issues from CDT experts) testimony, papers, and other reports here.
Name | Author | Issues | Date |
Testimony of Ari Schwartz Testimony: Testimony of Ari Schwartz before the Senate Judiciary Committee on "Passport Files: Privacy... |
Ari Schwartz | 7/10/2008 | |
Testimony of Ari Schwartz Testimony: Testimony of Ari Schwartz before the Committee on Homeland Security and Governmental Affairs on... |
Ari Schwartz | 6/18/2008 | |
Written testimony and prepared oral statement of Sophia Cope Testimony: Written testimony and prepared oral statement of Sophia Cope before the Senate Committee on... |
Government Fails to Enforce Privacy on New IDs Commentary: Balancing national security and civil liberties requires delicate diplomacy to ensure a balance... |
Leslie Harris | REAL ID | 1/25/2008 |
Federal ID Proposals for US Citizens and Others Grow in Number and Scope Policy Post: Federal ID Proposals for US Citizens and Others Grow in Number and Scope (1) Federal ID Proposals... |
1/18/2005 |


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This week in Comment, Margaret Talbot looks at how gun-control measures are losing support in Congress and recommends that such legislation should be treated with urgency, despite the perceived political consequences: http://nyr.kr/Y3jEYI
Illustration by Tom Bachtell
(Source: newyorker.com)
Postscript: Robert Bork, 1927-2012
Robert Bork, who died Wednesday, was an unrepentant reactionary who was on the wrong side of every major legal controversy of the twentieth century.
- Jeffrey Toobin. Continue reading: http://nyr.kr/WsJ5XE
Photograph by CNP/Getty.
So much for "health-care Monday," which had Washington and the media world in a rare tizzy. Shortly after ten o'clock this morning, John Roberts and his colleagues handed down a bunch of rulings, some of them significant, such as one that struck down part of the Arizona immigration law, but none of them pertaining to the Affordable Health Care for America Act, a.k.a. Obamacare. The justices, like producers of a Hollywood soap opera, were keeping their best plot twist for the end.
John Cassidy on how the Supreme Court gave hope to both sides on health care: http://nyr.kr/MTu2LH
Kelefa Sanneh on the Supreme Court's decision about immigration law, "Another Anticlimax…": http://nyr.kr/KXNcpK
Nation of Immigrants: In this week's Comment, Steve Coll looks at President Obama, Senator Marco Rubio, and the Criminalization of Immigrants http://nyr.kr/LcR67I
Abortion has been a flashpoint of American politics for so long that it can be wearying to think about it. There is always a temptation to think that it will, somehow, fade away as an issue. But it doesn't and it hasn't. And, in 2012, abortion remains—more than ever, in fact—the biggest and clearest difference between Republicans and Democrats.
The G.O.P.'s Abortion Problem: http://nyr.kr/N3Rcjf


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Diabetes Mellitus
•Chronic metabolic disorder characterized by high blood sugar (hyperglycemia = > 126 mg/dl)
•Affects CHO, Fat & Protein Metabolism • Damages: Blood Vessels (Heart Disease, Stroke, HTN, PAD); Nerves (neuropathy); Kidney (nephropathy); Eyes (retinopathy) •Caused by Insulin Deficiency, Insulin Resistance Or both |
Incidence of DM
•Affects all age groups
•Affects 18.2 million people in US |
•Liver converts glucose to glycogen
•Glycogen stored in liver and muscle cells |
•Liver converts glycogen to glucose
•Liver Synthesizes glucose from non-carbohydrate sources:
•Amino acids, lactic acid, glycerol |
Primary energy source, provides 4kcal/gram
fat metabolism
9kcal/gram |
CHO to triglycerides (via liver) -> fatty acids (via lipase) -> Ketones (via liver) this occurs when large amounts of fatty acids are used for energy source, causes ketoacidosis/ metabolic acidosis
Protein Metabolism
4kcal/gram |
excess AA converted to FA ketones, or glucose. •Body breaks down proteins and uses the amino acids as a major substrate for GLUCONEOGENESIS
Kidney Regulation of Glucose
•Glucose almost totally reabsorbed by renal tubules
•However, when plasma glucose is > 180 mg/dl, glucose spills in urine (glycosuria) |
Brain & NS and Glucose
•Can only use glucose as energy source
•Only stores enough glucose to last few minutes •Prolonged & severe hypoglycemia can result in brain death |
Muscle tissue and glucose
•Uses either glucose or fatty acids
•At rest -> fatty acids •Exercise -> glucose •Muscle fibers more permeable to glucose during exercise due to contraction process even in absence of insulin. |
Alpha Cells of Pancreas
•Secretes Glucagon: ↑ BS
•Glucagon: Regulated by blood sugar level •↓ BS= ↑ Glucagon = ↑ BS •Maintains BS between meals & fasting/starvation states •↑ BS by ↑ hepatic glucose production |
Beta Cells of Pancreas
•Secretes Insulin= ↓ BS
•Insulin: Regulated by blood sugar level •↑ BS = ↑ Insulin = ↓ BS •Insulin receptors on cells of the body recognize insulin and allow glucose to be transported into the cell where glucose is converted to energy |
Action of Insulin
Promotes glucose uptake by target cells,
Promotes storage of excess glucose in fat cells, •Increases protein synthesis by increasing transport of amino acids into body cells •Inhibits protein breakdown |
↑ BS •Maintains BS between meals & fasting-starvation states
•↑ Hepatic glucose production |
•Epinephrine & Norepinephrine (adrenal medulla)
•↑ BS during stress •Promotes conversion of glycogen to glucose (Glycogenolysis) |
•Cortisol (adrenal cortex)
•↑ BS during stress •↑ Hepatic glucose production |
Growth Hormone
•Secreted by anterior pituitary
•Promotes protein synthesis in all cells, increases fat mobilization and use of fatty acids for energy and decrease use of CHO |
Diabetes Mellitus Type I
(juvenile onset, insulin dependent) |
accounts for 10% of cases, occurs at any age, Genetics and autoimmune responses plays a role,
S/S DM Type 1
Sudden onset,Body type thin, Peak age = 12 (although may occur any age)
,Fatigue / Listlessness, Polyuria, Polydipsia, Polyphagia, Weight Loss, Glucosuria, Ketoacidosis |
Diabetes Mellitus Type II
(adult onset, non-insulin dependent) |
•Accounts for 90% of all cases of diabetes characterized by
•Insulin Resistance ↓ Insulin Secretion ↑ Hepatic Glucose Production |
DM I etiology
Genetics: associated w/ Human Leukocyte antigen
Hypothetical Environmental Antigen: triggers autoimmune response, autoimmune response: destroys Beta cells |
Etiology of DM II
Insulin Resistance:
Fewer insulin receptor sites on cell membrane Insulin receptor abnormality Abnormality in glucose transporter -Function only after insulin binds to receptor site ↓ Insulin Secretion: •Hyprinsulinemia leads to beta cell exhaustion •Beta cells "poop out" ↑ Hepatic Glucoseroduction:• Insulin Deficiency Cells unable to use glucose as energy source •Cells starving •Liver converts glycogen to glucose •Worsens hyperglycemia |
DM II Risk Factors
Age >20, obesity (85% obese), Genetics (20-50%.. greater than type 1), Race (Black, Native Americans, Hispanics) Impaired Fasting Glucose (pre diabetes 110-125mg/dl), Gestational Diabetes (hyperglycemia in pregnancy 5-10yrs later), Insulin Resistance Syndrome (Metabolic Syndrome,Syndrome X,Presence of Four atherosclerotic risk factors:
Insulin resistance, Hypertension, Hyperlipidemia, Central obesity) |
MODY (maturity onset diabetes of the young)
DM II onset age <25yo,
•Often Obese •Genetic Defect ==> Autosomal Dominant |
> 40, Obese, 3 P's: (Polyuria, Polydipsia, Polyphagia), Skin infections, Vaginal Yeast Infections, Cystitis NO WEIGHT LOSS NO KETOACIDOSIS |
FPG: Fasting Plasma Glucose
•Normal; 70-100mg/dl,
•IFG "Pre diabetes": 110-125 mg/dl, •DM:> 126 mg/dl - confirmed with 2 FPG |
Random Blood Sugar
Non fasting test
DM= > 200 mg/dl PLUS the presence of classic sx |
Oral Glucose Tolerance Test |
•Used to detect gestational DM or to detect DM-2 in person who has a normal FPG
DM= > 200 mg/dl after 2 hours |
Hemoglobin AIC
•Normal = 4-6%
•Goal for DM = <7% •Determines how well DM is being managed •Reflects average glucose for the preceding 6-12 week period •Not affected by food intake, stress or exercise |
DKA: Diabetic Ketoacidosis
•acute complication in DM-1
•When Does it Occur? Onset of disease (before dx) Omit insulin or insufficient dose Illness or Physical-Emotional Stress ==> ↑ BS 2nd to ↑ Counter Regulatory Hormones |
Diabetes Lab findings
•↓ pH (< 7.35)
•↑ BS (often 600-700) •↓ HCO3 (< 15 mE/L) •Ketones in blood and urine •Glucose in urine •Compensate = Kussmaul's respirations |
Hyperglycemic Hyperosmolar Nonketotic Coma |
Acute complication of DM 2
•Lab Findings BS > 600 mg/dl Serum osmolarity > 310 mOs/L No ketoacidosis |
Hypoglycemia or Insulin Reactions
Occurs in DM-1 or DM-2
BS = < 50 mg/dl |
S/S Hypoglycemia
↓ Cerebral Function, Autonomic NS Activity; conscience-> injest sugar, unconscience-> HOSPITALIZE
Somogyi Phenomenon
Occurs with DM-1
•Morning hyperglycemia 2nd nocturnal hypoglycemia •Nocturnal hypoglycemia Occurs because evening dose of insulin too high •Morning Hyperglycemia = Compensatory response ↑ counter regulatory hormones ↑ Hepatic glucose production •Confirm Somogyi effect by measuring BS 2-3 am •Tx: Decrease evening insulin dose |
Dawn Phenomenon
•Occurs in DM-1 or DM-2
•Morning hyperglycemia without nocturnal hypoglycemia •Caused by circadian rhythm secretion of growth hormone •Tx:Increase PM insulin dose Switch evening NPH to HS |
Chronic complication of DM- microvascular disorder
all DM1, 60% DM 2 damage/ruptured blood vessels in eyes |
Chronic complication of DM- microvascular disorder
•DM-1: present after 15 years •DM-2: present at time of dx •Affects blood vessels that supply glomeruli •Leading cause of ESRD •First sign of diabetic nephropathy is an ↑ urinary albumin excretion (microalbuminuria) •Microalbuminuria defined as urine protein loss between 30-300 mg/day. |
Chronic complication of DM- microvascular disorder
•Endothelial thickening of blood vessels that supply nerve -> nerve ischemia •Demyelinization of Schwann Cells which slows nerve conduction Peripheral Neuropathy • Most common •Affects lower extremities •Numbness / Tingling •Loss of Sensation |
Chronic Complications of DM-
Macrovascular Disorders |
•DM-2: present at time of dx
•DM-1: onset depends on age & duration of DM CAD (agina, MI), CVA(stroke), PAD (pain/intermittent claudication) |
•Small gland located in front of neck just below "adam's apple"
•Consists of two lateral lobes connected by an isthmus •Covered by sternomastoid muscle •Usually NOT palpable |
Thyroid function
•Takes iodine and converts it to thyroid hormones - T3 & T4
•Iodine Necessary for synthesis of thyroid hormones |
Follicular Cells
•Functional unit of thyroid gland;
•Tiny sac-like structures that absorb iodine; •Combine iodine and tyrosine (amino acid) to make T3 and T4. •Have approximately 2-3 months supply of thyroid hormone stored in gland |
•Insufficient thyroid hormone
•↓ BMR •Slows down all body activity •Classification Congenital Acquired |
Congenital Hypothyroid
•Affects approx 1 of 4000 births
•Caused by -Absent thyroid gland -Inadequate hormone production - Deficient TSH •Cretinism=manifestations of untx congenital hypothyroidism -Growth retardation -Mental retardation Tx: Hormone replacement |
Acquired Hypothyroid
Primary Hypothyroid = Thyroid Gland Dysfunction
Secondary Hypothyroid = Hypothalmic or Pituitary Dysfunction (less common) |
Causes of Hypothyroidism
•Hashimoto's Thyroiditis (most common)
•Surgical-induced hypothyroidism • Radiation-induced hypothyroidism |
Hashimoto's Thyroiditis
•Most common
•Primarily affects women (5:1 ratio) •Autoimmune disorder form autoantibodies which react with thyroid antigens destroys gland •May produce transient hyperthyroid state = leakage of preformed thyroid hormone from damaged cells |
Surgical Induced Hypothyroid
•Complete or partial removal of thyroid gland |
Radioactive Iodine (RAI)
• Used to tx hyperthyroid
• Thyroid gland concentrates RAI •Destroys gland become hypothyroid |
S/S Hypothyroidism
Sx Vary ==> May be subtle or overt
Gradual onset, weekness and fatigue, skin dry and course Hair course and brittle, Accumulation of hydrophilic mucopolysaccharide substance, Puffy appearance especially around eyes, Bradycardia, Decreased RR, Decreased appetite, Menorrhagia, Easy fatigueabiity, Physically/mentally sluggish, Severely hypothyroid, unable to metabolizes sedatives, analgesics and anesthetic drugs, ↓ T3, T4, ↑ TSH, ↑ Cholesterol |
•Excess thyroid hormones
•↑ BMR •Accelerates all body activity |
Primary Hyperthyroid
Thyroid gland dysfunction
Secondary Hyperthyroid
Hypothalamus or Pituitary Dysfunction
Hyperthyroid Causes
•Graves' Disease (most common cause)
other causes not discussed |
Grave's Disease
•Autoimmune Disorder
Abnormal stimulation of thyroid gland by thyroid stimulating immunoglobulins (TSI) TSI Bind to TSH receptors on thyroid gland Competes with TSH ↑ T3,T4 •Affects mostly women (7:1 ratio) •Onset usually 20-40's •Familial Tendency / Genetics 15-20% of pts have close relative with the disorder |
S/S Grave's Disease
Presentation may be subtle or dramatic ==> Depends on hormone level, Onset: Insidious, heat intolerance, smooth velvety skin, thin fine silky hair, breakable nails, Graves Dermopathy (Rare occurs after many years), Exophthalmos (occurs in 1/3 pts), Goiter (2-3x normal size), Increased CO, Tachycardia, Angina, SOB with exertion, increased appetite, Amenorrhea, muscle protein breakdown= used as fuel, Restless, anxious, nervous, insomnia, difficulty concentrating, Increased sensitivity to catecholamines (epi/norepi)
• ↑ T3, T4 • ↓ TSH • ↓ Cholesterol |
Adrenal Glands
located on the top of each kidney; Composed of : Adrenal Medulla & Adrenal Cortex
Epi and Norepi. Hormones of Adrenal Medulla.
•Increase BP, HR, Respirations •Increases peripheral vasoconstriction •Increases sweating |
Hormone of Adrenal Cortex
•Cortisol (Hydrocortisone) = major Glucocorticoid •Protects against stress •Raises Blood Sugar •Depletes Tissue Protein •Mobilizes Fatty Acids for Energy (instead of glucose) |
Hormone of Adrenal Cortex:
•Regulates Na+, K+, & Water levels |
Sex Hormone
•Adrenal cortex produces small amounts of sex hormone in both males and females
Cushing's Syndrome
•↑ Glucocorticoid / Cortisol
•Syndrome refers to a constellation of clinical features of ↑ cortisol from any cause •4 x more common in women than men •Onset = 30-50 YO |
Causes of Cushing's Syndrome
Pituitary Tumor -> Increased ACTH
Adrenal Tumor -> Increased Cortisol Lung Cancer -> Increased ACTH Long term prednisone therapy -> Suppresses ACTH |
S/S of Cushing's Syndrome
Wide range of emotions, Moon face (full/round), Overt DM develops in approx 20% of pts, Muscle Wasting esp. in extremities, Decreased humoral and cell mediated immunity, Mask infection/inflammation, (Increased Androgen) Acne, Facial hair (hirsutism), Osteoporosis, (loss of collagen) Produces thin/weak integumentary tissue, Peptic ulcers, Increased Na/water retention -> Hypertension, edema, Increased ACTH -> melenocyte stimulating activity
Primary Adrenal Insufficiency
•↓ Cortisol,↓ Aldosterone, ↑ ACTH
•Relatively rare •5 cases / 100,000 persons •Female:Male = 2:1 ratio Autoimmunity: (•Destruction of adrenal gland •Makes up about 80% of Cases) Other: •Metastatic destruction of adrenal gland •Tuberculosis - common in countries where TB is prevalent •Adrenal hemorrhage (anticoagulants/trauma) •Adrenal infarction (thrombosis) |
S/S Primary Adrenal Insufficiency
Gradual onset, Sx appear when 90% of gland destroyed, (↓ Cortisol) Hypoglycemia
Poor tolerance to stress, infection, trauma, (↓ Aldosterone):• Excrete Na/Water; Retain K+, Hypovolemia, Hyponatremia, Hyperkalemia, Hypotension, Weight loss ↑ ACTH: Melenocyte stimulating activity ↓ Androgen: Females = sparse axillary/pubic hair |


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It's All Politics Change Of Plans In Change Of Plans: O'Donnell To Be At Iowa Tea Party Event August 31, 2011 Meanwhile, Sarah Palin has plans to be in Iowa and New Hampshire over Labor Day weekend.
The Two-Way VIDEO: Christine O'Donnell Walks Out On CNN's Piers Morgan August 18, 2011 She thought he was being rude by asking about issues she writes about in her new book. He said he was being "charming and respectful."
The Two-Way Delaware's O'Donnell Fires Back At 'Thug Politic Tactic' December 30, 2010 There was "no impermissible use of campaign funds whatsoever," the Tea Party/Republican candidate for Senate said this morning, as she responded to allegations about improper use of campaign money for personal expenses.
The Two-Way Reports: Feds Probing Christine O'Donnell's Use Of Campaign Funds December 29, 2010 The Associated Press and Wilmington's News Journal say authorities are looking at whether the Tea Party Republican spent some of the money given to her Senate campaign for personal expenses. She says she has nothing to hide.
The Two-Way Break 'Quote Of The Year' Tie: Christine O'Donnell Or BP's Tony Hayward? December 13, 2010 A Yale librarian who tracks such things says "I'm not a witch" and "I'd like my life back" tied for 2010's best quotes. Which would you pick? Or is there another that was "better?"
It's All Politics Chris Coons Defeats Christine O'Donnell In Delaware: CNN, AP November 2, 2010 Coons' victory over O'Donnell was expected and a vindication for the GOP establishment which warned that she was a weak candidate and rued the loss of a Senate seat the party could have picked up.
It's All Politics Christine O'Donnell Closes Gap With Chris Coons In Pre-Gawker Poll October 29, 2010 The GOP Senate nominee is now 10 points behind the Democrat, cutting his lead in half in two weeks. The poll was conducted before the controversial Gawker which has created something of a sympathy backlash for her.
It's All Politics Christine O'Donnell Stuns Audience With 1st Amendment Gaffe October 19, 2010 Christine O'Donnell appeared not to know that the First Amendment requires the separation of church and state. She revealed this lack of knowledge at a debate with rival Chris Coons at before an audience of law professors and students.
It's All Politics In Del., O'Donnell Survives Debate With Coons October 13, 2010 Christine O'Donnell appeared comfortable on TV; her rival Chris Coons more in command of facts.
It's All Politics Christine O'Donnell TV AD: 'I'm Not A Witch' October 5, 2010 Christine O'Donnelly, the GOP nominee for a Senate seat from Delaware, opens herself to fresh ridicule with her new ad in which her opening lines are "I am not a witch."
It's All Politics Delaware's Mike Castle Won't Be Write-In Candidate September 30, 2010 Rep. Mike Castle (R-DE) won't run as a write-in candidate in the race for a U.S. Senate seat. It remains a two-way contest between the woman who beat him in the Republican primary, Christine O'Donnell, and Democrat Chris Coons who holds a large lead.
It's All Politics Poll: 'Significant Majority' Might Vote Against Obama September 27, 2010 A new survey from Politico and George Washington University signals discontent with the president over changes in health care laws and his efforts to get the economy moving.
Political Junkie Delaware's Mike Castle Considering Write-In Effort To Save Senate Bid September 27, 2010 Mike Castle, the Delaware Republican who lost his Senate primary to a Tea Party-backed challenger in an upset, is considering running as a write-in candidate.
It's All Politics Tea Party's Christine O'Donnell 15 Points Behind Chris Coons September 21, 2010 Chris Coons, the Democratic nominee for the Senate seat in Delaware, doesn't have Republican Christine O'Donnell's celebrity, But he has something more important, a 15-point lead in the latest Fox News poll.
Political Junkie Tea Party Furious At Murkowski Write-In, But O'Donnell Did It In '06 September 20, 2010 The Tea Party Express and other opponents of Alaska Sen. Lisa Murkowski may be angry with her, but they aren't expressing the same misgivings about what Delaware's O'Donnell once did.
It's All Politics O'Donnell Preaches Anti-Elite Message September 17, 2010 After riding Tea Party fervor to a stunning win in Delaware's Republican Senate primary, Christine O'Donnell brought her us-against-the-D.C.-ruling-class-elites message to a Values Voter crowd, promising a "revolution of reason."
It's All Politics Karl Rove Makes Democrats' Case Against Christine O'Donnell, Again September 15, 2010 Karl Rove continued to provide Democrats with ammunition to use against Christine O'Donnell, the GOP nominee for a Senate seat from Delaware.
It's All Politics Rep. Mike Castle Won't Endorse O'Donnell: Report September 15, 2010 A source or sources inside Rep. Mike Castle's campaign says he won't endorse winner Christine O'Donnell, the Tea Party favorite who won the GOP Senate nomination.
It's All Politics Christine O'Donnell Gets Top Republican Support For Now September 15, 2010 Christine O'Donnell got support from Sen. John Cornyn, head of the National Republican Senatorial Committee committee who gave her $42,000, a maximum contribution.
It's All Politics ANALYSIS: Castle's Loss Is Victory For Partisanship September 15, 2010 COMMENTARY: The long-time Delaware lawmaker has been a political bridge-builder and at a time of hyper-partisanship his presence in the Senate might have helped get things moving.
It's All Politics In Delaware, O'Donnell Beats Castle For GOP Senate Nod September 14, 2010 Christine O'Donnell led Mike Castle in Delaware with more than 41 percent of the vote counted.
It's All Politics Delaware's O'Donnell A 'Fraud' Ex-Aide Tells Politico September 14, 2010 Christine O'Donnell, pick of the Delaware Tea Party for the GOP Senate nomination, was hit by a highly negative robocall by an ex aide calling her a "complete fraud."


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Fire-breathing robot invades city hall
A giant, fire-breathing robot has taken over part of Osaka's city hall.
Its baby face makes it the perfect instrument for striking terror into the hearts of the 2.6 million residents of this Japanese metropolis.
The metal monster is called Giant Torayan and it stands over three stories tall. It can spew 20-foot-long jets of flame from its infant lips. See the video below.
Constructed of steel, aluminum and brass, the robot is the brainchild of Japanese artist Kenji Yanobe, who describes it thus: "This Giant Torayan doll is the ultimate child's weapon, as it sings, … Read more


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Rigoni di Asiago Fiordifrutta Organic Fruit Spread Raspberry -- 8.82 oz
This product is deeelicious!
This is an excellent product. Organic and sweetened with apple juice. I wish Vitacost would get more flavors, such as Cherry and Black Currant, which are my favorites. Blueberry and Blackberry are wonderful too...but I want my Cherry and Black Currant!
No other fruit spread compares to Rigoni diAsiago. Once you have this fruit spread you will not want any other. I love it.
August 4, 2013
The best
It is the best...organic, no sugar and deeeelicious!
July 22, 2013
Delicious! Real raspberries, real raspberry taste.
I am very happy with this organic fruit spread. It taste very fruity and it isn't sweetened with sugar.
May 4, 2013
Superb product in everyway, and not least of all it is only sweetened with applejuice, a big plus!
April 13, 2013
Great product
This jam is so rich and delicious. Yummy and good for you.
January 2, 2013


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Distributor: Paramount Vantage Starring: Synopsis: When a weathered, God-fearing ex-blues musician finds the town nymphomaniac severely beaten and left for dead on the side of the road, he vows to cure her of her wicked ways in Hustle & Flow director Craig Brewer's raw and unflinching follow-up. Lazarus (Samuel L. Jackson) is a hard-living ex-blues guitarist for whom the troubled days are beginning to outnumber the good. Rae (Christina Ricci) is a 22-year-old sex addict whose wild ways are finally about to catch up with her. When Lazarus discovers ... Full Synopsis
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Website | mappingsuite.com |
Category | Software |
Phone | 33 3 20 14 66 66 |
Employees | |
Founded | 1988 |
Description | print management software |
Venture Round, 11/2007 CIC Investissement Nord CM-CIC Capital Prive | $2.23M |
MAPPING SAS develops print management software. Its products include MAPPING Suite, which allows the users to design, print, archive, fax, email, and consult documents locally or remotely; MAPDRAW, a document template composition tool; MAPREPORT, which extracts data from various sources; MAPOFFICE, an automated word processing software module; and OUTPUT MANAGER that manages spool files. The company's products also include MAPOUT, which electronically archives, searches, and displays spool files; MAPGED, which archives scanned documents; MAPWEB, a document publishing solution; MAPCOM, an automated emailing and faxing solution; MAPSEND that allows the emailing of remapped spool files in the PDF format; and MAPPING VERSION MANAGER, which manages the structure of the organization. It also offers printing chain audit and guidance, project management and contracting assistance, software and licenses installation, technical integration, technical support helpdesk, and maintenance services. The company serves banking and insurance, industrial, and retail customers.
MAPPING SAS, formerly known as Coginord SA, was founded in 1988. The company is headquartered in La Madeleine, France.


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Alien Big Cat (ABC) reports from the Paranormal Database
Large Black Puma
Location: St Mawgan (Cornwall) - RAF St Mawgan Date / Time: April 2004 Further Comments: Military surveillance equipment was set up around the airbase following several reports of a large black cat seen on the site. A spokesperson said that the RAF would make 'every possible attempt to ensure it is captured humanely'. Even though a professional tracker was called in, the creature was never caught.
Lion or Teddy Bear?
Location: St Osyth (Essex) - Field off Earls Hall Drive Date / Time: 26 August 2012 Further Comments: Residents of this village were asked to stay indoors while people at a nearby caravan park were evacuated after the police warned the public that a lion may be on the loose, having been presented with a grainy image of a cat in a field. After police helicopters and armed officers found nothing, the photo was released in the press. The owner of a large domestic cat named Teddy Bear said the 'lion' looked like her pet, which is known to bask in the sun in the same field.
Large Cat
Location: Stansfield (Suffolk) - Exact location not known Date / Time: July 1996 Further Comments: This feline was seen from a distance of about 25 metres.
Roe Deer Kill
Location: Stroud (Gloucestershire) - Woodchester Park Date / Time: January 2012 (corpse found), and throughout 2012 Further Comments: The corpse of a roe deer discovered by a member of the public had wounds similar to animals killed by big cats. The National Trust, who own the land, said they were carrying out tests on the body - these later came back with only deer and fox DNA detected. Video footage was also captured of the 'Stroud Valleys Wildcat' a couple of years prior to this attack, although was only analysed in 2012, with opinions differing to whether the creature was an ABC or just a large domestic cat.
Large Black Cat
Location: Sudbury (Suffolk) - Henny Road Date / Time: 28 September 2010, 05:30h Further Comments: While driving home this witness watched a large black cat, 'as large as a Boxer dog', run from out of a hedge into the car headlights. The creature continued to run along the road for a short distance before vanishing into another hedge.
Black Puma
Location: Telford (Shropshire) - Area around Blockleys Brickmaker's Date / Time: September 1999 Further Comments: Clear CCTV footage showed a large (around two meters in length) black cat stalking the neighbourhood. The RSPCA stated the creature was indeed a puma.
Yellow Eyed Cat
Location: Telford (Shropshire) - Silkin Way Date / Time: Early 2011 Further Comments: After hearing rustling in nearby bushes, a walker approached closer only to hear loud cat-like screeching. As they backed away, a large black cat with yellow eyes was spotted.
Black Cat with Glowing Eyes
Location: Thetford (Norfolk) - Woods Date / Time: April 1985 Further Comments: A large cat with eyes that glowed red was reported in the forest.
Green Eyes
Location: Thompson (Norfolk) - Unstated road in the area Date / Time: 2004, around midnight Further Comments: A witness returning home by car spotted a large cat just a few metres away from a deer. He stated that he saw the perfect side profile of the creature just before it disappeared into the hedge: a long sleek body with a long tail drooping to the ground and then hooking upwards.
Location: Tilgate (Sussex) - Tilgate Forest Date / Time: 10 September 1979 Further Comments: A sleek black cat was seen hiding in the forest.
Light Brown Cat
Location: Todmorden (Yorkshire) - Bacup Road Date / Time: February 2011 Further Comments: Licensee of the Masons Arms Lynne Goldfield reported observing a brown cat with high hind legs as she walked her dog along this road.
Location: Tollerton (Nottinghamshire) - Area near airport Date / Time: Summer 1976 Further Comments: Dozens of witnesses reported seeing a large cat that resembled a lioness, though no hard evidence was ever produced.
Dark Fawn ABC
Location: Tolleshunt Knights (Essex) - Exact location not known Date / Time: January 1996 Further Comments: Possibly the same creature seen in Great Wigborough, the ABC observed here was thought to be a lion.
Cat Attack
Location: Trellech (Gwent) - Woods near the village Date / Time: August 2000 Further Comments: Joshua Hopkins, aged 11, was attacked by a strange cat 150 centimetres in length. The claw marks that were left on his cheek had to be treated in hospital.
Cat Crossing Road
Location: Tunstall Forest (Suffolk) - Road cutting through the area Date / Time: 20 April 2004 Further Comments: While driving through the forest, this woman saw a large unidentified cat cross the road ahead of her. She reported it was between 4.5 feet - 5.5 feet in length, including the tail. When it was mentioned to a forest warden later in the day, he said it was not an uncommon report in that particular area.
White Cat
Location: Turin (Angus) - Fields near Turin House Date / Time: Day time, Summer, 1989 Further Comments: A mother and daughter watched a large white cat close to woodland over a period of fifteen to twenty minutes. They compared the size of the cat to that of a deer.
Vectis Monster
Location: Vectis (Isle of Wight) - General area Date / Time: 6 January 1940 Further Comments: An early ABC report from the UK, this creature was said to have a head of a lion, though the body resembled a dog. Deaths were reported in the local livestock population.
Panther Size Cat
Location: Warter (Yorkshire) - Woods near Warter Priory Date / Time: 2001, circa 15.30h Further Comments: While walking their dog, this witness watched a large black cat leap across the path twenty yards (18 metres) ahead of them. The dog, which was running around freely, immediately ran back to the owner, and both walked back the way they had came.
Alsatian-Sized Cat
Location: Welham Green (Hertfordshire) - Station Road, woodland near Date / Time: 2007 Further Comments: Andrew Hollings, out walking his dog in the evening, encountered a cat 'the size of a Labrador or Alsatian with a long tail'. The creature slowly emerged form woodland.
Beast of Brookmans Park
Location: Welwyn (Hertfordshire) - General area Date / Time: 2005 Further Comments: Named the 'Beast of Brookmans Park' by the local press, this panther was spotted by several people during 2005.
Location: Wendover (Buckinghamshire) - Main Exit to Woods Date / Time: September 2006 Further Comments: A driver reported passing along this road and slowing down for what they assumed was a large black dog. As they approached, they realised the creature was in fact a very large black cat.
Chiltern Puma
Location: Wendover (Buckinghamshire) - RAF Halton housing estate Date / Time: May 1983, and 2005 Further Comments: In May 1983, four women encountered the 'Chiltern Puma' while walking through the estate - the creature past within three metres of the group. The cat was seen a half dozen times during that year, in over a three week period, all within a thirteen mile radius. In 2005 another witness reported seeing a large black creature close to the old RAF hospital site.
Beast of the Bay
Location: Whitby (Yorkshire) - Several areas, including abbey, St Peter's Court woods, and surrounding villages Date / Time: 2001 onwards Further Comments: A black panther-like cat has been observed a dozen times over a seven year period, on one occasion the cat was accompanied by a cub.
Big and Black
Location: Willingham (Cambridgeshire) - Exact area unknown Date / Time: February 1996 Further Comments: This typical large black cat seen at some distance.
Flecked cat
Location: Winchcombe (Gloucestershire) - Area around Mount View Drive Date / Time: April 2012 Further Comments: Several witnesses reported seeing a large cat in the area of this new housing estate. One woman said it was the size of a Labrador with a flecked brown coloured coat. Fur from the creature had been recovered, but at the time of writing, DNA analysis has not been carried out on the evidence.
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Nov14-12, 04:22 PM
Sci Advisor
HW Helper
What is the difference between the two, in that EM calorimeter will stop photons and electrons effectively wheras hadronic calorimeters stop hadrons effectively (but both do not seem to affect much muons)? What materials are used in each type?
One usually hears that the EM calorimeters interact electromagnetically whereas the hadronic calorimeters interact via the strong force. This is misleading since charged hadrons do interact electromagnetically, of course, and the em calorimeters contain nuclei which do interact via the strong force, so what makes something a good material for use in an em calorimeter or a good material for a hadronic calorimeter? I know that the mass must be a key factor in explaining why charged hadrons do not interact much within the em calorimeters (they must interact *some* but apparently not much) but what explains the difference of interaction between the hadrons and the EM and hadronic calorimeters, respectively? Thanks |
Nov14-12, 08:05 PM
The names are a bit misleading.
In both calorimeters there are electromagnetic interactions and nuclear/strong interactions. The EM calorimeters usually have a material of high Z (Sensitive to EM interactions) and hadronic calorimters have material with High A (Sensitive to hadronic interactions). That usually makes a difference of no more than a factor 2 in that respect. The naming really comes about form the fact that EM calorimters are designed to stop photons and electrons and prevent the EM shower from leaking into the hadronic calorimeter. These are the particles which on average loose there energy on the shortest distances. The same would be true if the hadronic calorimeter would come first. Many hadrons still loose most of there energy in the EM calorimter via strong interactions. However, unlike photons and electrons, sometimes some of there energy leaks into the hadronic calorimeter. In that respect, the hadronic is a leakage detector. It mainly stops hadronic showers from penetrating through into the muon chambers, where a high a purity of muons can be reached, Higher mass is the reason why charged pions and muons loose much less energy in EM interactions than electrons. |
Nov15-12, 09:05 AM
You can even build both from the same material and together - electromagnetic showers will be stopped earlier, and that part acts as electromagnetic calorimeter then. Hadrons can start their showers in the electromagnetic calorimeter, but they continue (and deposit most of their energy) in the thicker part behind - the hadronic calorimeter.
As an example: The electromagnetic calorimeter at LHCb corresponds to 25 EM interaction lengths (=> all EM showers will be stopped within), but just 1.1 hadronic interaction lengths (many showers will start there, but deposit their energy in the hadronic calorimeter behind). The hadronic calorimeter corresponds to 5.6 hadronic interaction lengths. |
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Sensory nerve
From Wikipedia, the free encyclopedia
A sensory nerve is an enclosed, cable-like bundle of sensory nerve fibers in the nervous system.
Nerve: Sensory nerve | |
Latin | nervus sensorius |
Code | TA A14.2.00.022 |
External links[edit]
This neuroscience article is a stub. You can help Wikipedia by expanding it. |


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Found December 21, 2012 on
State of the Texans:
J.J. Watt, Texans 2012 Team MVP
The Houston Texans have voted for their end of the season awards. All awards are voted on by the players…..
Texans 2012 award winners. DE Watt is team MVP. QB Schaub wins Ed Block Courage Award. RG Jones is Rookie of Yr. C Myers gets Bruener Award.
— Houston Texans (@HoustonTexans) December 21, 2012
Explanation of Ed Block and Mark Bruener Awards
Mark Bruener award is given to the player who exemplifies outstanding leadership, sportsmanship, work ethic and commitment to his teammates.
— Houston Texans (@HoustonTexans) December 21, 2012
Ed Block Courage Award annually honors 1 player from every NFL team who exemplifies commitment to principles of sportsmanship and courage.
— Houston Texans (@HoustonTexans) December 21, 2012
Past Team MVPs
Previous #Texans team MVPs: @briancushing56 (2011), @arianfoster (2010), @johnson80 (2008-09)
— Nick Scurfield (@NickScurfield) December 21, 2012
Original Story:
The Texans can clinch home field throughout the AFC Playoffs this week. Week 16 playoff scenarios.
Texans looking to corral Peterson, and secure homefield against Vikes
Texans auction to benefit Newtown
Kevin Faulk Reveals Great Gifts He's Received From Teammates in Wake of Arian Foster's Holiday Gesture (Video)
Texans donating to Conn. shooting victims
Foster buys Segways for Texans offensive line
Arian Foster gives Segways to his offensive linemen
Houston Texans to Add Two New Mega-Video Screens to Reliant Stadium
Johnson perfect complement in Texans offense
Arian Foster Buys His Offensive Line Segways For Christmas
Texans to Watch: Vikings Edition
Minnesota Vikings at Houston Texans: Week 16 NFL Pick
Is J.J. Watt the next Reggie White? Maybe so
Vikings' key versus Texans is slowing Watt
NFL Forum Discussions
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The team raced their newest vehicle, Eleanor, a total of 3,021 kilometers from the northern city of Darwin to Adelaide in South Australia, in five days. Eleanor is the 10th solar vehicle that the MIT Solar Electric Vehicle Team has built and raced since 1984. The vehicle's performance in this year's competition ranked among the team's best finishes.
Designed and built by the SEVT in 2008 and 2009, the car, weighing 430 pounds without a driver, is a fully solar-powered electric vehicle built from high-tech composites and containing the state-of-the-art in power electronics.
Power is provided by an array of six square meters of silicon solar cells that outputs a maximum of 1200 watts — less than most hairdryers. Despite this, the car with a driver can maintain highway speeds throughout the day. The array charges a battery pack designed by Genasun, a company founded by a SEVT alumnus, composed of 551 extremely high energy density lithium-ion cells donated by Panasonic. The pack is able to power the car without recharging from Boston to New York.
The MIT Solar Electric Vehicle Team is a student-run organization that designs, builds, tests, and races a solar vehicle on a two-year design cycle. Consisting mainly of undergraduates, the team competes in domestic and international competitions. The SEVT operates with the support of its sponsors, including Infinesse Corp., MIT's Edgerton Center, Ford, and Panasonic Corp.


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Ault Insurance Brokers is a trading name of J Sydney Ault Ltd.
For more than a century, Ault Insurance has provided reliable personal and business insurance to clients in the Black Country, the West Midlands, the UK and beyond. We offer comprehensive insurance solutions for property, vehicles, commercial activities, individuals and groups, with customer service that's second to none.
The STA has dealt with Aults for over a quarter of a century. As International experts in safety training solutions we have significant potential risks which are all insured through Aults...
Roger Millward
Chief Executive, Swimming Teachers Association
Read More
Important changes to the Civil Justice rules relating to the conduct of bodily injury claims will be introduced on 1st April and 31st July 2013
If you have visited our offices in West Bromwich, you will not have failed to see our display of fire insurance marks in our reception area...
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