text: 27 Share This Story!Let friends in your social network know what you are reading aboutFacebookEmailTwitterGoogle+LinkedInWATCH: Dave Owens On Tracking TigerWATCH: Dave Owens On Tracking TigerPost to FacebookWATCH: Dave Owens On Tracking Tiger on WUSA9.com: http://on.wusa9.com/1bdSnbw Incorrect please try again Try Another Audio Captcha Image CAPTCHA Help {# #} CancelSendPosted!A link has been posted to your Facebook feed." Sent!A link has been sent to your friend's email address.Join the ConversationTo find out more about Facebook commenting please read the Conversation Guidelines and FAQsWATCH: Dave Owens On Tracking Tiger Dave Owens On Tracking Tiger WUSA 9 Staff, WUSA 7:17 p.m. EDT June 29, 2012SHARE 27 CONNECTTWEETCOMMENTEMAILMOREBETHESDA, Md. (WUSA) - The second day of the A T & T National Tournament at Congressional Country Club resulted in an up and down round for for Tiger Woods.Watch the above video to see Dave Owens' report on Tiger's game.More Stories:


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In a real-life episode that seemed like a cross between the 2006 film Snakes on a Plane and the old Twilight Zone episode about a gremlin on a plane's wing (also re-made for the 1983 movie), a 10-foot python hitched a ride on a two-hour flight from Australia to Hong Kong.
No human was hurt as the snake stayed outside the plane, wedging itself in between the plane's fuselage and wing. But it ended badly for the reptile. In a video shot by passenger Robert Weber, blood is appears by the end of the clip, suggesting that whipping around during flight -- and the cold and high altitude -- got the best of the beast.
Watch the video of a witness account below.
What's the weirdest thing YOU'VE ever seen on an airplane?

subset: commoncrawl


text:
The BSN to DNP Mental Health Nurse Practitioner program prepares registered nurses (RNs) who hold a Bachelor of Science in Nursing as psychiatric-mental health nurse practitioners.
Graduates of the program are equipped to provide a wide range of services to adults, children, adolescents, and their families in a primary care facility, outpatient mental health clinic, psychiatric emergency services, skilled nursing and assisted living facilities, private practice, or in a hospital or community health center.
PMHNPs diagnose, conduct therapy, and prescribe medications for patients who have psychiatric disorders, medical organic brain disorders or substance abuse problems. They are licensed to provide emergency psychiatric services, psychosocial and physical assessment of their patients; treatment plans, and manage patient care. They may also serve as consultants or as educators for families and staff. The PMHNP has a focus on psychiatric diagnosis, including the differential diagnosis of medical disorders with psychiatric symptoms, and on medication treatment for psychiatric disorders.
During the first two years of the DNP/PMHNP program, students complete coursework in the Master of Science in Nursing (MSN), preparation that uniquely qualifies them develop the PMHNP skillset within the context of the integrated health micro-system.
Faculty Project Descriptions
For more information about the program, please contact Susana Torres in the School of Nursing and Health Professions (San Francisco main campus) at (415) 422-2806 or firstname.lastname@example.com.
Graduates meet the outcome competencies and practice standards of the American Association of Colleges of Nursing (AACN) for the Doctor of Nursing Practice degree. In the program, students complete 1,000 hours of supervised clinical practice, complete the DNP qualifying examination, and complete an evidence-based practice project (which replaces the dissertation). The program is accredited by the Western Association of Schools and Colleges.


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Brent Richard Pease
Position: QB
Height: 6-2 Weight: 201 lbs.
Born: October 8, 1964 in Moscow, ID
College: Montana (school history)
Drafted by the Minnesota Vikings in the 11th round (295th overall) of the 1987 NFL Draft.
Weighted Career AV (100-95-...): 3 (10215th overall since 1950)
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text:
Systematic (IUPAC) name | |
2-(2-(2,6-dichlorophenylamino)phenyl)acetic acid | |
Clinical data | |
Trade names | Aclonac, Cataflam, Voltaren |
AHFS/Drugs.com | monograph |
MedlinePlus | a689002 |
Pregnancy cat. | C (AU) C (1st. and 2nd. trimenon), D (third trimenon) |
Legal status | Prescription Only (S4) (AU) P (UK) Rx-only most preparations/countries, limited OTC in some countries, manufacture and veterinary use is banned in India, Nepal, and Pakistan due to imminent extinction of local vultures |
Routes | oral, rectal, intramuscular, intravenous (renal- and gallstones), topical |
Pharmacokinetic data | |
Protein binding | more than 99% |
Metabolism | hepatic, no active metabolites exist |
Half-life | 1.2-2 hr (35% of the drug enters enterohepatic recirculation) |
Excretion | 40% biliary 60% urine |
Identifiers | |
CAS number | 15307-86-5 |
ATC code | D11AX18 M01AB05, M02AA15, S01BC03 |
PubChem | CID 3033 |
IUPHAR ligand | 2714 |
DrugBank | DB00586 |
ChemSpider | 2925 |
ChEBI | CHEBI:47381 |
ChEMBL | CHEMBL139 |
PDB ligand ID | DIF (PDBe, RCSB PDB) |
Chemical data | |
Formula | C14H11Cl2NO2 |
Mol. mass | 296.148 g/mol |
(what is this?) (verify) |
Diclofenac (INN; see trade names below) is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. It is supplied as or contained in medications under a variety of trade names.
The name "diclofenac" derives from its chemical name: 2-(2,6-dichloranilino) phenylacetic acid. Diclofenac was originally developed by Ciba-Geigy (now Novartis) in 1973.[1] It was first introduced in the UK in 1979.[2][3]
In the United Kingdom, India, Brazil, and the United States, diclofenac may be supplied as either the sodium or potassium salt; in China, it is most often supplied as the sodium salt, while in some other countries it is only available as the potassium salt. Diclofenac is available as a generic drug in a number of formulations, including diclofenac diethylamine, which is applied topically. Over-the-counter (OTC) use is approved in some countries for minor aches and pains and fever associated with common infections.
Medical uses[edit]
Diclofenac is used to treat pain, inflammatory disorders, and dysmenorrhea.[4]
Inflammatory disorders may include musculoskeletal complaints, especially arthritis, rheumatoid arthritis, polymyositis, dermatomyositis, osteoarthritis, dental pain, TMJ pain, spondylarthritis, ankylosing spondylitis, gout attacks,[5] and pain management in cases of kidney stones and gallstones. An additional indication is the treatment of acute migraines.[6] Diclofenac is used commonly to treat mild to moderate postoperative or post-traumatic pain, in particular when inflammation is also present,[5] and is effective against menstrual pain and endometriosis.
As long-term use of diclofenac and similar NSAIDs predisposes for peptic ulcer, many patients at risk for this complication are prescribed Arthrotec - a combination of diclofenac and misoprostol, a synthetic prostaglandin (PGE1) analogue, to protect the gastric mucosa.[citation needed]
Diclofenac is also available in topical forms under the brand names Flector, Pennsaid, Solaraze, and Voltaren for the treatment of conditions such as osteoarthritis, actinic keratosis, and acute pain caused by minor strains, sprains, and contusions (bruises).[7]
In many countries,[8] eye drops are sold to treat acute and chronic nonbacterial inflammations of the anterior part of the eyes (e.g., postoperative states).[citation needed] A common brand name is Voltaren-ophtha.
Investigational uses[edit]
Diclofenac is often used to treat chronic pain associated with cancer, in particular if inflammation is also present (Step I of the World Health Organization (WHO) scheme for treatment of chronic pain).[9] Good results (sometimes better than those with opioids) have been seen in the pain associated with bony metastases.[citation needed]
Diclofenac can be combined with opioids if needed. Under trade names such as Combaren and Voltaren Plus, a fixed combination of diclofenac and codeine (50 mg each) is available in Europe. Combinations with psychoactive drugs such as chlorprothixene and/or amitriptyline have also been investigated and found useful in a number of cancer patients.[citation needed]
Fever due to malignant lymphogranulomatosis (Hodgkin's lymphoma) often responds to diclofenac.[citation needed] Treatment can be terminated as soon as the usual treatment with radiation and/or chemotherapy causes remission of fever.
Diclofenac has been found to increase the blood pressure in patients with Shy-Drager syndrome and diabetes mellitus[citation needed]. Currently, this use is highly investigative and cannot be recommended as routine treatment.
Diclofenac has been found effective against all strains of multidrug-resistant E. coli, with a MIC of 25 micrograms/ml. Therefore, it may have the capacity to treat uncomplicated urinary tract infections caused by E. coli.[10] It has also shown effectiveness in treating Salmonella infections in mice,[11] and is under investigation for the treatment of tuberculosis.[12]
Diclofenac is an antiuricosuric.[13]
- Hypersensitivity against diclofenac
- History of allergic reactions (bronchospasm, shock, rhinitis, urticaria) following the use of aspirin or another NSAID
- Third-trimester pregnancy
- Active stomach and/or duodenal ulceration or gastrointestinal bleeding
- Inflammatory bowel disease such as Crohn's disease or ulcerative colitis
- Severe insufficiency of the heart (NYHA III/IV)
- Pain management in the setting of coronary artery bypass graft (CABG) surgery
- Severe liver insufficiency (Child-Pugh Class C)
- Severe renal insufficiency (creatinine clearance <30 ml/min)
- Caution in patients with pre-existing hepatic porphyria, as diclofenac may trigger attacks
- Caution in patients with severe, active bleeding such as cerebral hemorrhage
- NSAIDs in general should be avoided during dengue fever, as it induces (often severe) capillary leakage and subsequent heart failure.
Side effects[edit]
- Diclofenac is among the better-tolerated NSAIDs. Though 20% of patients on long-term treatment experience side effects, only 2% have to discontinue the drug, mostly due to gastrointestinal complaints.[citation needed]
Following the identification of increased risks of heart attacks with the selective COX-2 inhibitor rofecoxib in 2004, attention has focused on all the other members of the NSAIDs group, including diclofenac. Research results are mixed, with a meta-analysis of papers and reports up to April 2006 suggesting a relative increased rate of heart disease of 1.63 compared to nonusers.[14] Professor Peter Weissberg, Medical Director of the British Heart Foundation said, "However, the increased risk is small, and many patients with chronic debilitating pain may well feel that this small risk is worth taking to relieve their symptoms". Only aspirin was found not to increase the risk of heart disease; however, this is known to have a higher rate of gastric ulceration than diclofenac.
A subsequent large study of 74,838 users of NSAIDs or coxibs found no additional cardiovascular risk from diclofenac use.[15] A very large study of 1,028,437 Danish users of various NSAIDs or coxibs found the "Use of the nonselective NSAID diclofenac and the selective cyclooxygenase-2 inhibitor rofecoxib was associated with an increased risk of cardiovascular death (odds ratio, 1.91; 95% confidence interval, 1.62 to 2.42; and odds ratio, 1.66; 95% confidence interval, 1.06 to 2.59, respectively), with a dose-dependent increase in risk."[16] In Britain the Medicines and Healthcare Products Regulatory Agency (MHRA) said in June 2013 that the drug should not be used by people with serious underlying heart conditions—people who had suffered heart failure, heart disease or a stroke were advised to stop using it completely.[17]
Diclofenac has similar COX-2 selectivity to celecoxib.[18] A review by FDA Medical Officer David Graham concluded diclofenac does increase the risk of myocardial infarction.[19]
- Gastrointestinal complaints are most often noted. The development of ulceration and/or bleeding requires immediate termination of treatment with diclofenac. Most patients receive a gastro-protective drug as prophylaxis during long-term treatment (misoprostol, ranitidine 150 mg at bedtime or omeprazole 20 mg at bedtime).
- Liver damage occurs infrequently, and is usually reversible. Hepatitis may occur rarely without any warning symptoms and may be fatal. Patients with osteoarthritis more often develop symptomatic liver disease than patients with rheumatoid arthritis. Liver function should be monitored regularly during long-term treatment. If used for the short-term treatment of pain or fever, diclofenac has not been found more hepatotoxic than other NSAIDs.
- As of December 2009, Endo, Novartis, and the US FDA notified healthcare professionals to add new warnings and precautions about the potential for elevation in liver function tests during treatment with all products containing diclofenac sodium.[20]
- Cases of drug-induced hepatotoxicity have been reported in the first month, but can occur at any time during treatment with diclofenac. Postmarketing surveillance has reported cases of severe hepatic reactions, including liver necrosis, jaundice, fulminant hepatitis with and without jaundice, and liver failure. Some of these reported cases resulted in fatalities or liver transplantation.
- Physicians should measure transaminases periodically in patients receiving long-term therapy with diclofenac. Based on clinical trial data and postmarketing experiences, transaminases should be monitored within 4 to 8 wk after initiating treatment with diclofenac.
- Studies in Pakistan showed diclofenac caused acute kidney failure in vultures when they ate the carcasses of animals that had recently been treated with it. Drug-sensitive species and individual humans are initially assumed to lack genes expressing specific drug detoxification enzymes.
- NSAIDs "are associated with adverse renal [kidney] effects caused by the reduction in synthesis of renal prostaglandins"[21] in sensitive persons or animal species, and potentially during long-term use in nonsensitive persons if resistance to side effects decreases with age. However, this side effect cannot be avoided merely by using a COX-2 selective inhibitor because, "Both isoforms of COX, COX-1 and COX-2, are expressed in the kidney... Consequently, the same precautions regarding renal risk that are followed for nonselective NSAIDs should be used when selective COX-2 inhibitors are administered."[21]
Mental health[edit]
- Mental health side effects have been reported. These symptoms are rare, but exist in significant enough numbers to include as potential side effects. These include depression, anxiety, irritability, nightmares, and psychotic reactions.[22]
- Bone marrow depression is noted infrequently (leukopenia, agranulocytosis, thrombopenia with/without purpura, aplastic anemia). These conditions may be life-threatening and/or irreversible, if detected too late. All patients should be monitored closely. Diclofenac is a weak and reversible inhibitor of thrombocytic aggregation needed for normal coagulation.
- It induces warm antibody hemolytic anemia by inducing antibodies to Rh antigens; ibuprofen also does this.[23]
- Diclofenac may disrupt the normal menstrual cycle.
- Research (published 2010) has linked use of diclofenac to an increased risk of stroke.[24]
Mechanism of action[edit]
The exact mechanism of action is not entirely known, but the primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis.[25]
Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid.[citation needed] This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.[citation needed]
The action of one single dose is much longer (6 to 8 hr) than the very short half-life of the drug indicates.[citation needed] This could be partly because it persists for over 11 hours in synovial fluids.[26]
Diclofenac may also be a unique member of the NSAIDs. Some evidence indicates it inhibits the lipoxygenase pathways,[citation needed] thus reducing formation of the leukotrienes (also pro-inflammatory autacoids). It also may inhibit phospholipase A2 as part of its mechanism of action. These additional actions may explain its high potency - it is the most potent NSAID on a broad basis.[27]
Marked differences exist among NSAIDs in their selective inhibition of the two subtypes of cyclooxygenase, COX-1 and COX-2.[citation needed] Much pharmaceutical drug design has attempted to focus on selective COX-2 inhibition as a way to minimize the gastrointestinal side effects of NSAIDs such as aspirin. In practice, use of some COX-2 inhibitors with their adverse effects has led to massive numbers of patient family lawsuits alleging wrongful death by heart attack, yet other significantly COX-selective NSAIDs, such as diclofenac, have been well tolerated by most of the population.[citation needed]
Besides the well-known and often-cited COX-inhibition, a number of other molecular targets of diclofenac possibly contributing to its pain-relieving actions have recently been identified. These include:
- Blockage of voltage-dependent sodium channels (after activation of the channel, diclofenac inhibits its reactivation also known as phase inhibition)[citation needed]
- Blockage of acid-sensing ion channels (ASICs)[citation needed]
- Positive allosteric modulation of KCNQ- and BK-potassium channels (diclofenac opens these channels, leading to hyperpolarization of the cell membrane)[citation needed]
Ecological effects[edit]
Use of diclofenac in animals has been reported to have led to a sharp decline in the vulture population in the Indian Subcontinent, a 95% decline in 2003,[28] 99.9% decline as of 2008. The mechanism is, it is presumed, renal failure, a known side effect of diclofenac. Vultures eat the carcasses of livestock that have been administered veterinary diclofenac, and are poisoned by the accumulated chemical,[29] as vultures do not have a particular enzyme to break down diclofenac. At a meeting of the National Wildlife Board in March 2005, the Government of India announced it intended to phase out the veterinary use of diclofenac.[30] Meloxicam is a safer candidate to replace use of diclofenac.[31] It is more expensive than diclofenac, but the price is coming down as more drug companies begin to manufacture it.[32]
"The loss of tens of millions of vultures over the last decade has had major ecological consequences across the Indian Subcontinent that pose a potential threat to human health. In many places, populations of feral dogs (Canis familiaris) have increased sharply from the disappearance of Gyps vultures as the main scavenger of wild and domestic ungulate carcasses. Associated with the rise in dog numbers is an increased risk of rabies"[31] and casualties of almost 50,000 people.[33] The Government of India cites this as one of those major consequences of a vulture species extinction.[30] A major shift in transfer of corpse pathogens from vultures to feral dogs and rats can lead to a disease pandemic causing millions of deaths in a crowded country like India; whereas vultures' digestive systems safely destroy many species of such pathogens.
The resulting multiplication of feral dogs in India and Pakistan has caused a multiplication of leopards feeding on those dogs and invading urban areas looking for dogs as prey, resulting in occasional attacks on human children.[34]
The loss of vultures has had a social impact on the Indian Zoroastrian Parsi community, who traditionally use vultures to dispose of human corpses in Towers of Silence, but are now compelled to seek alternative methods of disposal.[31]
Diclofenac has been shown also to harm freshwater fish species such as rainbow trout.[35][36][37][38]
Pennsaid is a minimally systemic prescription topical lotion formulation of 1.5% w/w diclofenac sodium, which is approved in the US, Canada and other countries for osteoarthritis of the knee.
Flector Patch, a minimally systemic topical patch formulation of diclofenac, is indicated for acute pain due to minor sprains, strains, and contusions. The patch has been approved in many other countries outside the US under different brand names.
Voltaren and Voltarol contain the sodium salt of diclofenac. In the United Kingdom, Voltarol can be supplied with either the sodium salt or the potassium salt, while Cataflam in some other countries is the potassium salt only. However, Voltarol Emulgel contains it as dichlofenac diethylammonium where 1.16% is equivalent to 1% of the sodium variety.
Diclofenac is available in stomach acid-resistant formulations (25 and 50 mg), fast-disintegrating oral formulations (25 and 50 mg), powder for oral solution (50 mg), slow- and controlled-release forms (75, 100 or 150 mg), suppositories (50 and 100 mg), and injectable forms (50 and 75 mg).
Diclofenac is also available over-the-counter in some countries: 12.5 mg diclofenac as potassium salt in Switzerland (Voltaren dolo), the Netherlands (Voltaren K), United Kingdom (since October 2008 as Voltarol Pain-eze), and preparations containing 25 mg diclofenac as the potassium salt in Germany (various trade names), New Zealand, Australia, Japan, (Voltaren Rapid), and Sweden (Voltaren T and Diclofenac T). Diclofenac as potassium salt can be found throughout the Middle East in 25-mg and 50-mg doses (Cataflam). Solaraze (3% diclofenac sodium gel) is topically applied, twice a day for three months, to manage the skin condition known as actinic or solar keratosis. Parazone-DP is combination of diclofenac potassium and paracetamol, manufactured and supplied by Ozone Pharmaceuticals and Chemicals, Gujarat,India
Trade names[edit]
Trade names include:
- Aclonac Emulsi Gel
- A-fenac (Bangladesh)
- Abitren
- Acteric (Costa Rica)
- Almiral
- Anaflex (Argentina)
- Anuva
- Arthrotec (combination with misoprostol)
- Artifen (Pakistan Abbott Laboratories LTD)
- Befol
- Berifen
- Betaren
- Bufenac Forte
- Cambia
- Cataflam
- Catafast
- Caflam (Pakistan)
- Clafen
- Clofast
- Clonac
- Dedolor
- Deflamat
- Deflox
- Diclac
- Diclo M (India & Myanmar) V.I.P Pharma
- Dicloberl
- Diclobene
- Diclo-Denk (Germany)
- Diclofenac
- Diclofenac-Asteria (USA and Korea)
- Diclofenaco Normon (Spain)
- Diclofenacum
- Dicloflam (South Africa)
- Dicloflex
- Diclogem
- Diclogesic (Jordan and Romania)
- Diclohexal
- Diclon
- Diclomar (Argentina)
- Diclomex (Finland)
- Dicloran (Malaysia)
- Diclowin Plus (India)
- Diclon
- Diclopar (Tanzania)
- Diclotab (Laos)
- Diklofenak T Actavis (Sweden)
- Difen
- Difenac (Venezuela)
- Difene
- Difnal (Malaysia)
- Dinac (Nepal)
- Dioxaflex (Latin America, Central America)
- Disflam K (diclofenac potassium, Central America)
- Dolex
- Dolphin (Egypt)
- Dolmina (Czech Republic)
- Dyloject
- Feloran
- Fenac (diclofenac potassium, Australia)
- Flamrase
- Flector Patch
- Flogozan (Mexico)
- Idinac (India)
- Immunagel (India)
- Kemoren (Indonesia)
- Klodifen
- Modifenac
- Morbidic (India)
- Motifene
- Naklofen
- Neofenac (Bangladesh)
- Neopyrazon (United Laboratories, ASIA)
- Oflam
- Olfen
- Ortofen
- Phlogin - Diclofenac Sodium (Pakistan)
- Panamor
- Parazone-DP (combination of Paracetamol & Diclofenac potassium)
- Pennsaid
- Pritaren
- Rapidus
- Rapten-K
- Reactin (India)
- Rhumalgan
- Rofenac (Middle East)
- Rufenal
- Safeguard (combination with misoprostol)
- Sandoz (diclofenac sodium, Australia)
- Solaraze
- Seradic (India)
- Topac
- Trabona
- Tratul (Austria, Romania, Moldova)
- Uno
- Veltex CR (South Africa)
- Vetagesic
- Viclofen (Australia)
- Voldic
- Volini (India)
- Volfenac (Thailand)
- Voltaflam (India)
- Voltaren (Argentina, Australia, Belgium, Egypt, France, Germany, Israel, New Zealand, Norway, Portugal, Russia, South Africa, Sweden, Turkey)
- Voltaren Emulgel (Australia, Canada, New Zealand, UK)
- Voltaren Gel (US)
- Voltarol
- Voltarol Emulgel
- Voltarol Pain-eze
- Voltfast
- Voren (Taiwan)
- Voltral (UK, Pakistan)
- Votrex
- Vostar
- Votalin (China)
- Voveran
- Vurdon
- Zipsor
- Zolterol
- Zengesic (combination of Paracetamol & Diclofenac sodium)
- Hitflam (Ambee Pharmaceuticals Ltd. Bangladesh)
- ^ http://www.novartis.com/about-novartis/company-history/index.shtml
- ^ http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1434053
- ^ Salmann AR (1986). "The history of diclofenac". Am. J. Med. 80 (4B): 29–33. doi:10.1016/0002-9343(86)90076-8.
- ^ "Diclofenac Epolamine". The American Society of Health-System Pharmacists. Retrieved 3 April 2011.
- ^ a b "RUFENAL". Birzeit Pharmaceutical Company.
- ^ http://www.cambiarx.com/
- ^ http://www.mayoclinic.com/health/drug-information/DR600545
- ^ SPC Netherlands
- ^ WHO's pain ladder for adults
- ^ Mazumdar K, Dutta NK, Dastidar SG, Motohashi N, Shirataki Y (2006). "Diclofenac in the management of E. coli urinary tract infections". In Vivo 20 (5): 613–619. PMID 17091768.
- ^ Dutta NK, Annadurai S, Mazumdar K, Dastidar SG, Kristiansen JE, Molnar J, Martins M, Amaral L. (2007). "Potential management of resistant microbial infections with a novel non-antibiotic: the anti-inflammatory drug diclofenac sodium". Int. J. Antimicrob. Agents 30 (3): 242–249. doi:10.1016/j.ijantimicag.2007.04.018. PMID 17644318.
- ^ Dutta NK, Mazumdar K, Dastidar SG, Park JH (2007). "Activity of diclofenac used alone and in combination with streptomycin against Mycobacterium tuberculosis in mice". Int. J. Antimicrob. Agents 30 (4): 336–340. doi:10.1016/j.ijantimicag.2007.04.016. PMID 17644321.
- ^ Naidoo V, Swan GE (August 2008). "Diclofenac toxicity in Gyps vulture is associated with decreased uric acid excretion and not renal portal vasoconstriction". Comp. Biochem. Physiol. C Toxicol. Pharmacol. 149 (3): 269–74. doi:10.1016/j.cbpc.2008.07.014. PMID 18727958.
- ^ Kearney P, Baigent C, Godwin J, H, Emberson J, Patrono C (2006). "Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials". BMJ 332 (7553): 1302–8. doi:10.1136/bmj.332.7553.1302. PMC 1473048. PMID 16740558.
- ^ Solomon D, Avorn J, Stürmer T, Glynn R, Mogun H, Schneeweiss S (2006). "Cardiovascular outcomes in new users of coxibs and nonsteroidal antiinflammatory drugs: high-risk subgroups and time course of risk". Arthritis Rheum 54 (5): 1378–89. doi:10.1002/art.21887. PMID 16645966.
- ^ Fosbøl EL, Folke F, Jacobsen S, Rasmussen JN, Sørensen R, Schramm TK, Andersen SS, Rasmussen S, Poulsen HE, Køber L, Torp-Pedersen C, Gislason GH (2010). "Cause-Specific Cardiovascular Risk Associated With Nonsteroidal Antiinflammatory Drugs Among Healthy Individuals". Circ Cardiovasc Qual Outcomes 3 (4): 395–405. doi:10.1161/CIRCOUTCOMES.109.861104. PMID 20530789.
- ^ BBC: Heart risk warning over painkiller diclofenac, 29 June 2013
- ^ FitzGerald G, Patrono C (2001). "The coxibs, selective inhibitors of cyclooxygenase-2". N Engl J Med 345 (6): 433–42. doi:10.1056/NEJM200108093450607. PMID 11496855.
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- ^ http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm193047.htm
- ^ a b Brater DC (2002). "Renal effects of cyclooxygyenase-2-selective inhibitors". J Pain Symptom Manage 23 (4 Suppl): S15–20; discussion S21–3. doi:10.1016/S0885-3924(02)00370-6. PMID 11992745.
- ^ "Diclofenac Side Effects". Drugs.com. Retrieved 21 January 2013.
- ^ www.merck.com/mmpe/sec11/ch131/ch131b.html?qt=diclofenac&alt=sh#sec11-ch131-ch131b-174
- ^ ABC News: Study links Voltaren to strokes http://www.abc.net.au/news/stories/2010/09/14/3011102.htm
- ^ Dutta NK, Annadurai S, Mazumdar K, Dastidar SG, Kristiansen JE, Molnar J, Martins M, Amaral L (2000). "The anti-bacterial action of diclofenac shown by inhibition of DNA synthesis". Int. J. Antimicrob. Agents 14 (3): 249–51. doi:10.1016/S0924-8579(99)00159-4. PMID 10773497.
- ^ Fowler PD, Shadforth MF, Crook PR, John VA (1983). "Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis". Eur. J. Clin. Pharmacol. 25 (3): 389–94. doi:10.1007/BF01037953. PMID 6628528.
- ^ Scholer. Pharmacology of Diclofenac Sodium. Am J of Medicine Volume 80 April 28, 1986
- ^ Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout BA, Shivaprasad HL, Ahmed S, Chaudhry MJ, Arshad M, Mahmood S, Ali A, Khan AA (2004). "Diclofenac residues as the cause of vulture population decline in Pakistan". Nature 427 (6975): 630–3. doi:10.1038/nature02317. PMID 14745453.
- ^ "Vet drug 'killing Asian vultures'". BBC News. 2004-02-28.
- ^ a b "Saving the Vultures from Extinction" (Press release). Press Information Bureau, Government of India. 2005-05-16. Retrieved 2006-05-12.
- ^ a b c Swan G, Naidoo V, Cuthbert R, Green RE, Pain DJ, Swarup D, Prakash V, Taggart M, Bekker L, Das D, Diekmann J, Diekmann M, Killian E, Meharg A, Patra RC, Saini M, Wolter K (2006). "Removing the threat of diclofenac to critically endangered Asian vultures". PLoS Biol 4 (3): e66. doi:10.1371/journal.pbio.0040066. PMC 1351921. PMID 16435886.
- ^ Gill, V. New drug threat to Asian vultures BBC News December 9, 2009.
- ^ Rabies follows disruption in food cycle
- ^ Nature Shock, UK Channel 5 television, Tuesday 7 Sept 2010,8 to 9 pm.
- ^ Schwaiger et al. (2004). Aquat. Toxicol. 68(2): 141-150.
- ^ Triebskorn et al. (2004). Aquat. Toxicol. 68(2): 151-166.
- ^ Schwaiger & Triebskorn (2005). UBA-Berichte 29/05: 217-226.
- ^ Triebskorn et al. (2007). Analyt. Bioanalyt. Chem. 387(4):1405-1416.
External links[edit]
Wikimedia Commons has media related to Diclofenac. |


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18. Tobey Maguire and Carey Mulligan shoot scenes for the 'Great Gatsby!'
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Last night, Millionaire Matchmaker Patti Stranger, a huge fan of Nola Singer's designs came out to the home of her parents, Deena and Marty Singer, to celebrate the launch of her new jewelry collection at Intermix and Planet Blue the evening was hosted by Perrier-Jouet. |
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List Price: $11.99 Online Discount: 5% You Pay Only: $11.39Catalog #: MC203S ISBN-10: 8558410041 ISBN-13: 855841004102Dimensions: 17 x 17 inches / Weight: 0.35 LBSIn Stock?: YES
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Despite the benching of their best hitter, who missed an entire week of play while battling an illness, the Lady Bulldogs managed to pull off a 2-3 win Saturday over the visiting Lady Tigers of Hayden.
Hotchkiss pulled off a 27-25 win in game one. Setter Kelli Buhrdorf had a long string of serves, including two aces, to give the Lady Bulldogs an early 9-1 lead in game two.


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I was able to book a room for $88.00 which would be the most I would pay for this room. Location okay, friendly service, but a little worn all around the property.
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Upstate school mixes education and entertainment
UPDATED 10:47 AM EDT Mar 15, 2013Spartanburg school serves as role model in South Carolina.
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Atomic bomb 'Atomic bomb, to fall on city in mock raid. 1954 Mock atomic raid to last over hour. Mock atom raid blows Denver off the map. Denver razed 3n mock raid from Shreveport, La., air force says P 0
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Turkish Baths
Plunge into Harrogate's past at the town's fabulously tiled Turkish Baths. This mock-Moorish facility is gloriously Victorian and offers a range of watery delights – hot rooms, steam rooms, plunge pools and so on; a visit should last around 1½ hours. There's a complicated schedule of opening hours that are by turns ladies-only and mixed – call or check online for details.


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My daughter has the same love for paper dolls as I did as a kid, however her dolls just kept getting torn up by her little brother. Even the magnetic ones lost their heads! So, I was on a mission to figure out a way to let her be able to enjoy her paperdolls without the fear of her little brother being able to tear them apart.
So.. go... now... and check out my new tutorial on the Moda Bake Shop, Flat Emelie & Matt {named after my kiddos}
I hope you love them as much as I do.


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PwC's monthly report shedding light on the IASB's activities. This edition looks at (1) IASB's Discussion Paper on Conceptual Framework, (2) IASB Chairman's 'ten-point' plan to improve disclosures, (3) proposals for insurance contracts – the final act?, (4) IFRS foundation on global adoption of IFRS, (5) exposure draft on bearer plants, (6) IAS 39 amendments for novation of derivatives, (7) EU requirements on payments to governments, and (8) know your IFRS 'ABC': 'H' for hedging.
PwC's monthly report shedding light on the IASB's activities. The July/August 2013 edition looks at:
Our weekly guide and immediate alerts to the latest developments in accounting and reporting matters.


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Time after time, Cyndi Lauper reinvents herself. From being the girl who just wanted to have fun, she's now scored her first Broadway musical, Kinky Boots, and received her first Tony nomination! With much hype building, will this wacky girl from Queens win big this time around?
Ruled by Water signs -- Cancer Sun, Pisces Rising, Scorpio Moon -- Cyndi is a lady who goes with the flow. Lucky for her, the flow will be heading her way. Close to the day of the nomination announcement, a full Moon eclipse in Scorpio occurred, highlighting Cyndi's solar Fifth House, bringing sudden events that will affect her ego and entertainment sector. Then, when the Tony Awards happen on June 9, lucky Jupiter will head into Cancer -- fully entering on June 25. This means that the planets are aligning for Cyndi's success. To up the ante for Cyndi's win, a month prior to the show there will be a full Moon eclipse in Sagittarius, hitting her natal Tenth House, which rules career. Cyndi's chart shows prominence, and her luck is only moving up from June 25 onward!


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This is minus the h and ts and p and double slashes.Of course the dots are replaced with dot.Other than that it was pasted onto the title.
You can copy the address straight off the mb page paste it into your search bar and replace the dots with "." and it will go straight to the other board.


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Wednesday, March 12, 2014
The Associated Press
AUGUSTA — Services for Maj. Gregory Sanborn, second-in-command of the Maine Warden Service, were rescheduled due to the snowstorm.
Calling hours will be 4-6 and 7-9 p.m. Sunday. A celebration of life ceremony honoring the 47-year-old Sanborn will be 11 a.m. Monday, also at the Maine Criminal Justice Academy at 15 Oak Grove Rd. in Vassalboro.
The 23-year veteran of the warden service died Tuesday in hospice from cancer.
The events were rescheduled because Sanborn's family wanted to make sure that everyone who wants to attend can travel safely.
This story's headline was updated at 4:44 p.m. Sunday to correct the day of the funeral.


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British Open ChampionsThe following table lists the winners of the British Open Championship golf tournament from 1920 to the present. George Duncan was the first person to win the British Open in 1920 with a score of 303.
Information Please® Database, © 2007 Pearson Education, Inc. All rights reserved.
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Prep Time: 5 mins
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Senegalese thirsty to learn find an oasis in a simple library
In a nation of 40 percent literacy and great poverty, students read novels in lunch-break installments at this struggling civic institution.
Pikine, Senegal
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Fatima Ndoye has just finished "L'enfant noir," a novel based on the childhood of Guinean author Camara Laye. She could hardly put it down – except that she hardly had the chance to pick it up, either. She has been reading it in borrowed snatches of time when she races across the street from her school to the Pikine Library during her lunch break.
This crude library – a 15-by-65 foot room in a concrete cultural center – is a treasure trove for the 14-year-old, who says she tries to read a novel a week here during hour-long visits. The daughter of a construction worker who earns $10 a day, she can't afford the $2 library card nor the two passport-sized photos required to get one, so she reads the books in installments, a little every day.
Fatima, her blue school vest covering jeans and T-shirt, knows every corner of the library: She walks to a shelf that's three-quarters full and tells a visitor, "these are the novels." The shelf below, she says, are books about business. She wanders a few more steps, and indicates the children's section, picking up a picture book and rifling through the pages.
"When I was little," she muses, "I liked these books. But now I'm bigger and I've changed. Because you progress. You progress all the time. I'm 14 now, and I read much bigger books."
• • •
This bustling – even crowded – lending library, cobbled together with hope, donations, and volunteerism, is evidence of how strong demand is for more libraries in Senegal, which, as one of the world's poorest countries, has a 40 percent literacy rate. The single room off a sandy courtyard in the Leopold Sedar Senghor Cultural Center is the only public library in this city of 2 million.
Poverty aside, Senegal has a rich literary history. Among its celebrated authors is the country's first president and a world-renowned poet and intellectual, Leopold Sedar Senghor, for whom the center was named.
There are many development programs, paid for by the government and international aid organizations, working to teach basic reading skills and to get more children in school. But the director of the cultural center, Pape Baba Ndiaye, says funding is needed for the next step in the process – giving people access to books and information.
"The government says it dedicates 40 percent of the budget for education," Mr. Ndiaye says. "I would like to see more of that 40 percent given to books and public reading." Currently his library operates on a tiny fraction of the cultural center's budget of less than $40,000 and relies almost entirely on donations from nongovernmental organizations and embassies.
The state is doing what it can, he says. "There is a director of libraries, in the Ministry of Culture; there are library networks in the country." But he says it just isn't enough.
In a culture where stories are traditionally passed on orally, Ndiaye was fortunate to even have a model of a library to follow. He grew up in Medina, a crowded neighborhood in Senegal's capital, Dakar, "not very far from the library network in downtown," he says.
"Every Wednesday and Thursday evening, we didn't have school, so that's when we'd go to the library to read, to discover things. It helped us do our homework better."
When Pikine's current mayor was elected, he pledged to revitalize the library, which had been given space in the 1990s when the cultural center was built, but had long been ignored. Under Ndiaye's direction, it reopened in 2005 with thousands of donated books. He says the library now has over 10,000 volumes, but a glance around the room suggests the true number is far smaller.
Ndiaye's vision is to expand Pikine's library into branches, one for each of the city's 16 districts of sprawling concrete neighborhoods that are gridlocked with colorful minivan-buses, rickety taxis, boys selling newspapers between cars, and women selling peanuts on the sidewalk.


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the tremaine ! pianofortes i are acknowled by all who have them in use and by the first musical talent to be eqnai and in many respects superior to any manufactured thev combine immense fencer equality sweetness aud brilliancy q lone elasticity of louclt and great durability dealers teachers and others i desiring to purch_se a lirst-class instrumentare invited to examine these pianos before maki i ho ir selection elsewhere patent agraffe treble together with all modern improvements the most thoroughly reasoned timber the markel af ford ie selected regardless of cost as we feel asauredit will be the cheapest in the end the great increase in the alt of ou instru j ments has enabled us to reduce our prices for j first class pianos from ten to twenty-five per \ j cent less than any other bonsc offering il.e same class ofinstrument in the cnited states while we act upon the maxim of quick sa and bmall profits we make it at the same time a special object to furni our customers with instruments in no way inferior to the best in the market many families have had a de-ire to obtain a piano but could ml afford to pay the dealer a profit of frum 100 to .:!"". neither do they wish , to purchase a cheap made instrument that j would cost more to keep in n pair lhan it i wortb hence a large clai-8 ol our music loving i people have been obliged to do without we cau furnish new seven-octave piano fortes from 275 t 0 dollars second baud pianos trom 1 ... 50 dollars v parlies ordering by mail may rely upon . the best selections our pianos aie in 1 ly warranted for six years descriptive circulars senl to all parts of t!.o cotmiiy upou application . c m tremaine & brother manufacturers 435 broome street je\?7 li'cik o t the burdett j combination orgah with carpenter and burdctt's new improvements j the disagreeable reedy tone entirely over ; come in thii instrument tbf vertlirl iscbabimotis the lircntrst succr_sof llie ut !. tf challf llie world it i.tii ! ! and cordially invite the profession dealers and the musical world generally to examine this truly wonderful instrument the burdett coml>inat_i ai as its n sine indicates is an in pei usui ion ofall oar standard iui n-.o euls t.i i.ii i < \ ,\\, n -,,.\,\, new features nev.i bcfoi • iutrodnved or atu-miiu-d in reed orpins t..,_i-tl.t makiiij uat,t i n the m ni's ii.ika of iitsiinn t-i . mid oue tl.at i as al roady rrrati-il a revolution in tbe public mind in tbe decided favor of tbe general ad lion ol reed organs both for secular and sacred n.ustc _ i ere an instrument is required either to accouipanj tb voire or lo produce orchestral efle ts with the multitudinous and sui r slip ccn-bina tion i hat are con tan t.i in this inst in n nt the most intricate music of the great masici can l>e ren ifretl u on a grand organ : or tl .• mos simple iiiii . sic lor the ntelodeon can he played by a child all tli various improvenu nts on ;! e bt rdett t r pan are proteeted by patent bclonp exclusively tc il.s company and ran be u i ... uo othei organ the present burdett organ has n • eived t!ie niosi r..ri:al and highest eneonii nis from those rankin among tbe rratof musician and organists ts\t xt tr york independent says ofthe bur dett organ : it is by far the most j erfect reed instrument we have ever seen the christian leatur says : ' v el ad no idea tl al a reed instrument couid be bn u>;ht tosuch perfection " the xew york observer y its pnrit of voicing richness of ue and wonderful or ehestral combination ecther wiib a number . of new ami original , render it an int»trn ment ot such perfeol i^tobe beyond com petition ** the press and public everywhere who have had an opportunity of listening to its beautiful ■strains not only give it their u i ualifieil appro val but uuhe&itatingh concede tba it stands without a rival ll e burdett organ ran pis in price from 135 to 1000 i w ° ave also xew cabinet oigane at 45 i 100 c c freinaiibo uro r holes ale agents j.iy«tit>jr0se st.,ivew stouk sfc-tilj i il-1_?j upncani nil i is»3^^p—i^mi i 7i::w goods j mccubbins sullivan & co j v • : i . t i kail dn w ii terftocl ol i •,..;... - . vtii j • : i'i ' t»js fl i ■■■■■•■■■i ..... di ■-*•■. it i -' ' '■'■'■'*- '* i,r :|:"' . ,■. paint and l>y stuc iron and .-:■■. ■. sad i e harness and < oacli jr n r u p f-ole i }• r !!..!:.--■and skirting leather blasting anrl i ifie powder bagging and ties in fact every thing the peoi le need don't tail to call and see us they keep constantly on hand a larpe stock of guano phosphates lime <.'_. s ml in your oiler s s my n <*.. sept 19.1871 catawba n**r fj re v-.-v _, it v a <--.-■'- tt » ': w<ah\€£l 2l-a.a v,_7:_.^-_:y-.ju high school m wton n « . itev j c i lapp a ij i j m i imikii a m . principals j d rowe late of university of va assistant the i .-•--'. m of 20 eeks begius jan lary 1st i ri tuition frmn 10 t ya.r.'t ■, ■i -. - m 11 ard i.i au 1 •-■fr y < ? ■i i •••' :'<> tm ii.uie i ii ii it ili sale ■:' spiritu j ons liqnt-rs w it iti two miles of the institu tion the teachers have been regularly educ ted j f .|- tii ni ; i ..'.-. ;.. . tt three olleg.'s ll g thefirsl iii ti 1 •• and the discipiiiic ami i driu are thorough newtou is remarkab • ' . i.ea ti and mor i al ity for circular and iart:c'i?;irs a '■.-- ' lai l & t'i i newton dec .">• 13/j ii bpd i /* mf r a ! f jl_hli^__j j**"k'i*i&sdm o — pn th 3th q?y of january is 72 i v,ill sell at the court-house door in states ville the following valuable tracts and interests ; ii lands belonging to the estate of james f bell del-cast tl viz : number one | known as the xiaw^crtco tract two miles from statesville containing three1 hundred and thirty-two acres more or less : fn the warrs of fourth creek 40 to 60 acres ' of which is very ri i ere !, bol l m l''u or n.ore ! acres heavily timbered ii i uplands and the : i a in nee mostly cleared upland ; d joining the ' i lands of hayne davis esq and others | number two ; kr.c_'p as the cihscn rr»ct ron taining two li limited acres more or less three miles li om stall sville on the taylorsville r lad 0 in 60 acres well timbercil 40 to 50 a res re j t-tiilv cleared and the remainder more j worn but al level clay upland capable ofim-i i . i nt no broken washing land on it two branches ufibruing stock water number three i one-fifth interest in the t ___,. t.t i place adjoining no '_', the wliole of which | containing two hundred and seventy-four acres more or lesss ! number four one ot in the town of states ville known as the "( otton lot so designa . t ii in the \\ iii ; containing one and a half acres fronting on depot street and adj lining the de : pot lots terms o sal one-third - i cash one-third ? ' ai the e ■ii iti"ii of six months and oik third ;'. : within twelve months from day of sale interest on two last payments from : i dav of sale notes with approved security will be requir ; ed and title withheld until lull payment is i made persons whishing to examine said lands will please call on capt t a trice simonton j liouse statesville j hervey stevenson executor of j 1 rell dee'd november 1 1s71 also at the same lime ntl place i will -.•!! sundry notes tunl other claims for money and railroad stuck belonging to the estate ol 1 a i bell deceived 1 hi iivl.y stevenson j ixecntor i.v novi ml ■"' :. sti ii ltdsj sgi •■•••, : 4-v drrcan : «- v x s . j ■. -' - . .. -- 1 j - m . * 1 \ i .:■- o • * _. o i j i ■!•>'; ' v i \ i .* i ii v a ,;. tii i ■, . \ . . \ , great ' y (.';:.'■., ;':(] it 7 it-tec is oi li : - .-: i'si-in ii'ii inter i i , j " nc !•* : . ! ■. : ■i ! \ .-- \ nun iter ' i ■• • ■>. .;. :.■• . . i-j ■i ;:.;.(! c!e i i:7.-ip i .,.;: o •■;;■•..,■■7 • \ 117 . i - n ■.'. i t ': : ■; *.* -. a . s sj a i '. ; res i : < : .... ii ' •. . .'•. rchil ct re agri . ..:■:. uer i -. silence and art farmer il_*'han'l s 1n lktous engineers chei i ts mai ctnn rs and people of all i'mfe isiom or trade will l-'ii.d the sc 1 est fic a m k it i can of great value and interest its practical suggestions will save hundreds oi i!i iii to evi ry house t !.';.. workshop und factor in the land besides affording a con tinual source of valuable instruction the kditois are assisted by many of the ablesl american ami kttropi in writers and baring access to a'l the leading scientific and me ehani al jt irnal of tin v tn id :!.■• c lumi .• o the scientific v-iutrican are constnntlj enrich ed with lhe choicest information an 0ffical list , :' all the patentslssued is published weekly the yearly utunbers ol the scientific american make tv i spi ■:-. i 1 oiu nes i nearly one tbt.usand pages equivalent in size to pour thousand ordinary book pages specimen copies sent free term -. — v a year 1.50 flail vear clubs hi ii lines f i one v.-.i jj each f_5 0 with a spier did trcvrs ivm totheper.on wi is tbe v.iuo cousistuigi-la copy of the celebrated steel-piate engravinir men ol progress iu connection ■the publi ition of the 1 scient fie americau the in der igi d cmi i i i ■' " o ; extei sive agei ej in the world foi proc irii p r __._.__ !■_'_. s the besl way to obuin an answer to thi question can 1 obtain a paten ' is to write to m.ux.xr d cc 37 park row | ni-w _ ork woo li ve had ,, er twenty-five rears experience in the bnsii ess no charge ■'-:- :'■■opinion and advice a p ti-an'd ink sketch or full written descripti n of the inventii n sbould be sn t for instructions coiu-ernina american and euro ie patent — caveaw r ■.;--■,. -[■. terferences r.-jecud uases-riiits on selliui patents !. lies and proceedings ofthe patent i laws fa ansimuions-~e_tensions--infrin£re meuts etc etc send for instucction book which will i.em.n ed ime on applicniion vi i ti siness strictly confidi ntial address ivxulffw d co ; t publishers of the sen tic american \ 3t:13 3 park row new york e__9_b__!'_______s_3naan-a_s£-_bl_-abiaj"b_-l ■•*■» *■■■' special notices tiie great pictorial annual hosteller united slates almanac for 1-72 for distribution ijrt lis thrt ugliout the i nited suites nml iil civilized countri - ': the \\ cst ern hemisphere will lie published about tiie first of january in the english german french j norwegian welsh sweedish holland bo | in ni.iii and spanish languages and all who . wish tt understand the true philosophy of health j -!". nld nail and ponder tiie valuable sugges tions it contains in addition to an admirable medicai treaties on thu causes prevention and cure of a great variety of diseases it embraces a large amount of information interesting tothe merchant the mechanic the miner the farmer the planter the professional man and the cal culations have been made for such meridians and latitudes as are mi t suitable for a correct and comprehensive natioxax calendar the nature uses and extraordinary sanitary effects of hosteller's stomach bitters the sta ple tonic and alternative of more than half the christian world are fully set forth in its pages which are also interspersed with pictorial ill is iraii.in valuable recipes for the house a ni farm humorous anecdotes and other instruct ive ami amusing matter original and selected among the annuals to appear with the open ing of the year this will be one of the most use ful and miy be had for die asking the propri i ii-7 hosteller a smith pittsburgh l'u tm receipt of a two cent stamp will for ward a copy by mail to any p rson who cannot procure one in his neighborhood the bitters . nr ... i in everv city town unci village and arc i , .'• nsiv •!-. t set tin ■: ui tiie entire civilized svoi i . _ i iih cause am cure oe i 0n | blviil'lion . ■■. ._ a.m i w e i . u...-_iiij..i.i'ii is derange 1 . ie i .;'. i..i . i ",_..■..■....-• ms i-ii s derangement i ■u..uc u.ii.-.i.-tii u in a in ..;." i-s.i.;....i mi ny . ■_ . .:.,.,.. meal 7 i ;. ... .:.- io ivl.icll the nil lii.uii.il .), the i u b conveiieu miu blood and i ... , |. . . i oi tiie uou . fetxoua a ith di j ■un li.u .. i.'.i having tiie slightest pre-dis i..-.ii io paluioiitti disease or it tli take coid iviii i.i very u bie-to lutve consumption ol lhe ' lungs ..: .-.?....- nl its i inns and i bold tiiat 1 will i iiu uiijiossib.eiooa.ean casi old tisumption with j out :...-. resior.uga good digestion and liealthj as gimiiation il.e very lu'.-i tinug i be doue is to cleanse t ie stomach anil boweis from all d.seaseu unices ard slime ivhicli isciog^in l.'iese organs bu uiul tiiey caunot perform tue'u functions and j tiie rouse ii and restore i lie liver to a health ue tion i nr this p;ip se the sui est and best remedy ■; is schenek's au_.r_._e it iis i tiese pills clean the ! stomach ami bowels of all the dead and morbid slime that is causing disease and lecay in the whole : system 1 in y w li clear out the liver of all diseased j i bile that has aeearuulated tliere and roust n upto ! a new and healthy action by which natural und he tithy bile is secreted the stomach bo ve!s and liver i hus ele msed by the use nl ichen k's mandrake i'i iis but tin ... re : mams in the stomach an excess of acif i lie < rg n is torpid and the appetite poor in the bowels the ■; lacteais are • ■eak ;.;■.■requirirg strength anp sup port it is in a c mditiou like 7 is !• ut si nenoi s : seaweed i'onic proves to be the i o t va nab eieni | i-i ever discovered it is alkaline aud its use i will neutralize all excess ol acid making tlie**tou ■i n.ii sweet and fresh it will give permanent tone i ! to this important organ afld ereai a pood i early , oppeiite ami i n-ii ie the system foi tht lirst process : ni a good digestion and ultiniutel make good health . liviuu dlo id aftei this ep in ion in ut ment what remains to cure mosi case i rcon-'iimp i tion is the tree and persevering use of schenek's ; pulmonic syrup the pulmonic s rup uourisl es 1 i1 .• system pi nfiesthe bl i and is readih absorb i ed into the circulation nnd thence distri uted in : tiie diseased iuugs riiereii rij ns-all morbid mat ' u-is whether in the form of absesses oi tnheivies i and then assists nature to expel ail tie diseasi i matter in the form of free expectoration when once it ripens it is tin n bj the pr it he i ing aa.d '■purifying properties of sclienek'n pulmonic si j that all nlcersand cavities are healed up sound and in patient is cun i . ti.e e.-s nl ial i liiiis 1 1 i.e ft m in crinc con um tioi : i ip . l'ot.'i a •.':>: anrl n o.i . i . - i n s 1 n r i tlir l lv «- 11 _'. iii lies ii n-i i-i ftr !;_. i i |. rs li l!i s li r s lllll — il ■■\ 171 ..:" ■'.!'-. .-■tier . — t'r-l v-j i ily c imot ' e i the n a'ter v i.nnt ri . sn ion n t • r ■■. y i"n is 1 el tv |. . . w t - ne e.s try o tu . it ■■■n re rilt-r n f tli ii s n iroo it p lilt n n i nnl i i.-n id iot !■. .-. '••■fl ■(, mil _. 1 1 ■: then natur ishtljic-.l t •■,- :, -, ii . ■..■■- !,.. , the in tt»*r iil r en a:i 1 he 1 1 • r • n nl i arir u.ii.l es a nit the i-eson r.-jolin e = illi 11 nil 1 r jrth li s i r l me antl 01 lj 1 nn t cure c.n 1 su i ami i:7i . ers 11 is ■eiy l.tvl il tli i 11 r ■re 1 i ••■■' i tlt-sl r.'i - ■! <> nii i nt nnj . ii rtlypi — i ii i ■n .. i 1 ttal 7 ' ii •: the tir 0 lieal nji j ll rt i • . fe 1 7ii e -■■n '" an :: rs i s i un .! itli nly ■. - snui il lj v i :.. i e _. y if tl i p il ll ii ■■th s is •* 111 .- 1 f rk . ' .■,. - it ill o to vt ■e cot.sn i i n . t . y u i . ■■! .■n oui ilie s 111 rh sn eel en a .! st .■t 1 it.-i . t j np a _ ■i i ti in n _ ve a . tin ' i h c s 1 need to rlc r lie i lem full lie i.s •;. e '■' t i in he in a nrltati ver t e f nn nia.v b . i n mp riant lli 1 w iie usi .- pc fnck's mettic'n s ■a e i-lii ulii he exercisiil n t o lake c id ; teeji 11 loo s in c i ' and ih-.m no her v id nifftn air.an'i take out |.| r xerrise only in a gciiia1 nnd aim .:.-=■i 1 . ••. 1 tv h t ilisi nn ii n iii isio d i i'a i i ■en i recoirtmi n a h'i.'i.t t t e car - li 1 n reirard lo lakin old while u_i 1 my ' .:; ine 1 do .. : r p ri i reas 11 a 111 ■1 : j nl .. hat i u pa tia'.ly r f..v n il i lira ihe fl fl i a had cold s tar moie iiah'e i.<a reia 9 1i1 n one mho has heen ! nlir li cured ami i i.s pivris y th same in regarti to consumption .*.. 1 11 as the inn lire uot perlectly ! he 1 tl j'ii *" on 9 tli r i 1 inent danger . f :. i 11 re : inii oi t e isease ii • ie it s ti.nt ' ... st eiiuous y in ' pulmonary p-tients pa 1 exposinu lhe s • ive . i 11 ntn sph "• i a s :• i re1 ial and ,.!•■. sa t cont rni ' 1 . 11-11 t 1 i . . -' lungs ii . a m:_8 1.1 s res wh'cl lh '■.. sl i .-._..• am ph re nil flame le grand s c'e 0 ni sue ess h my me liciiies co si.-ts n my i it j i . n suhtl.ie nil mttiatio ins eati of t rov kin it as 1 ni m v -■! 1 1 fji oily :■■. n inflame u g cnn'.o it ill • alet t to 1 p-i i nt he e>p ed to the l-iliun b'a t ol ; •' nie .. ■i.'i in winds ol spring r autum . il is . 1 d *• e car f ly s!-i 11 • ■•' ir m a'l iiri ati g i flu nee 1 - ■1 ■-■1 e . 1 1 ... i .- <■' • 1 \ ■li iii his pa ic inr 1 -.- wi ■i a cur 11 e 1-i111 1 : a y c rvun.s-.aiice is an 1 , - ih.li-y j i ■l '.- rs t 1 m l i • n a iv .■lesom and rui r ' i tin s i u i a 1 1 • 1 : oni no 11 until li i j ' s 1 1 r t i tl.t " i 1 u...i;li ..•! flesh and 1 i ■1 1 i'n 1 ■• i : i i s ir.yi.tcu 1 tl in this t - t ml fllewrrsl k'nd nl 1 1 stun 7 n ii 1 h-v ! . : ; ; - fi nd hi art i i ■r \ a y a s it 11 in m i ... e ha e 1 1 01 sa >:« int.e :' ■v ry many hav been cured ! 7 il.'s ir a . nt i ' nvc 1 v i . • n i u ' first f "■•• ' er 1 • v eel 1 t kt pos-essionol . y nc bui i . a ti.e no ihea.t corner 0 .-;>. li a ' ; reli - e t . i •■i s a 1 b pi ased to fiv advice to | 1 ! i ■■:■■,\ r qui e .'. --'... i • t s - .• • pany al y i'.ni cf i - s pn t'.at a ne - i * rt . ■v '. i '.. r a ily in il by • 1 .■■t t a : h sam ". j ii -« iie ch m i ila,l--p a john f ' es 1 y s c . 1 ■.. p.a .-. new y i e 15 1 v 1 le ite ' i . u thousands attest its virtues anil from all quarters of the (..-' ibe come testimonials of won ■tei ful cures performed by simmons liver kegulator how to get money is tbegreat ties-ire oi ali a really g oil and servicable sewing machine ibat will maki money tor ytm or belp you to save it wili be seni to yia own home on trial i't'i :*'. days mi matter v in re ynu maybe \ and you can pay foi il in small monthly in stallments by writing t.o the great american machine oo cor john and nassau street sew york or you can have a coui.'.y i...'1 free as agent and ; lake : loney last we a ivi e small men to secure the tusineis as in ■:..-.:._ pays better tban the a ncj foi a good si vvii _ machine write.atonco * 3:iy notice to the ladies among the many useful inventions produced by the nineteenth century none occupies a mon prominent position than that of the sewing ma chine the cheerful imin of these tireless litilt j helpmates of onr mothers and wives may now ne beard in almost every house in the land — , fhey are mad..1 in endless variety and one is al most at a loss to chi osewhen there are so many of decided merit one of tbe latest and most improved is tin empiue manufactured by tbe l.mi'iiik sewixg maciiixk co '—'■', bowen n ". .. speedy no - ■•-•■and d x le and we can conscientiously reeomnn nd parties in search o n machine to give it an examination before ci n cluding to pur liase agents wapted liberal discounts given may2g:ly executors notice alli persons having claims against the estate of moutfml s mckenzie deet'a?*ed i are hereby notified to exhibii th sa i e to the | uiideisil'n.ii on r before the 23rd day of november a d 1**71 c h mekenzle john vv mckexzie executors of montfort s mckenzie deo'd nov ltf 1872 • 12:6t j allen beown h s taken the room recently occupied by overman holmes __ co in murphy's granite row and opened a produce cof-7.:_!isseossa business solicits cash orders from abro d produce bought and shipped on very abort notice re pectfully refers to business en of the city i jfpcash paid for all leading articles of country produce w l 1 davis ■• ** ••■si?<_i_i__i m ' nr-i £ nt 7 u ffl . 1 i ;* «_ i u i 9 ml h u n ar 1 . rock hill sr c solicits hipmenth ol flour meal wheat io ■.• d outs to be sold on commission ; ; o ■• h i 7 products to til should corres pond with it c and obtain market prices at i'oek hi 1 which can generally be done in 21 hours ; reference a i.n i shaver esq -»!:-. j 0 white salisbury dec 1,1871 ll:3m:pd ujo southern eacee?s inu barents a card from oes gordox my excr.se for addressing you mist be the great importance ofthe subject to which i would call attention—that of tin pre r education ofour children and the proper development of their self-respect and character 1 need not repeat any commonplaces in re gard io the lasting eiiect of early impressions ! the almost impossibility of diverting the minu from the bent given i in early years — all this you know as well as 1 nor need 1 say anything about the powerful silent influence in this edu cational work of the school books from which ; our children derive their views of right and wrong and their knowledg of the facts or mis representations of history — for this too you j km iw lull weil and whin i say that having been for long j years almost en tirelv dependent upon liie north i'or our school hooks we hive been compelled to use many which were very distateful tons because we had no alternative i only state that which every reader can substantiate long belore the wa we all felt the necessity for a change in this respec — the necessity for unobnox ions school books for unsectional un political books school books prepared by our own soli liars il tbat might be and since the war ilii necessity has increased ten-fold indi vidual efforts of ibe most praiseworthy charac tt ;• have from time to time teen made in this di rection by southern men but not of a sufficient ly comprenbensive natun lo accomplish llie purpose in view to meet the want thus ti i v felt sever al of our ripest scholars ■■■successful i teachers uniied in prcparii s of school oi ks unsurpassed by anv excellence beauty and cheapness maury wn ite geogrnphi ' i istn ni imy v enable wrote ariihm ies ' jebras c lit imes wrote history gi arsane kead l l's scheie de v r wn te fn nch books ( iiidi rsli eve wn • l ! '" ■' ks i ... lome wroti sciei tii hoi ks i.tinton made iv ruins books ic etc and lh combined seri sis ailed the unircrsity series of s , i /.'•*-,* a seriesnot only not objec tionable to our peoph , '■■; positively attractive to i degree hen to iore en ii ly unknown our history instiiutii :;- ai ! ... i ',' thought here receive im pari ia treatment * and instead of be ; in i iiion d i lie intt ■is if tiie south here re ci ive i ijnal i pr si nta i u tin n as to intrinsii ,. it wl o ? nows more about geography than maury or of llisiory and i rnmm n tl an lit inn ■. i r of matlieuia.ics than veil le ai . h on ton nigh all the ii-t v each author is a master in bis special depart tun it ii i for this seri s i i bt oks so excellent so acceptable wo cheap they are the cheapest ix ok published ihat your favor is solicited the books of the cm - •' series are present ed directly upon theirs s you are not asked to usi infei ior books if these two questions can be answered af firmatively : — are these books equal ti any in merit a re they as cheap as any ? should they not receive your preference ? what is more reasomd h than that southern schools ibould be supplied with books written by soutiit eru schol . -, provided the are equally goods with those written bj northern men is it not better both for us and for our children thai such inn ks should be used already the response whir was inevitable to this ruiestion has come more lhan 5,000 oi our ' est si eii in rn schooh are using these boi iks several southern states have already ;: opted ihem for exclusive use in tbeir public schools county boards in every southern state arc adopting them and th best private sei tools an replacing books hitherto used with them hie succcss of the university series is un prece de n'i d ii tin history of school i oi k publishing ami ii i destinc-d to be et greater i o the people ot the south desire to rid then - elvcs of obnoxious bo '.:- at d pernicious teach ing can il be belt ci done than by ti minim ons 1 v sustain ing this firsi c unpn hensivi education al enterprise of our own scholars and j>v inak i n ie " i i.i ct . shy .- s : ies tbe l'xifokm series im every - 1 ll'l 11 lil'.x state including of course any olher booksrhavin equal claim for consideration gursehools jvili then lie supplied with looks which they can long continue to use pupils compelled to change tin ir si i i ols will no loni'ir be retarded ii tbeir studies by a cl ai e ol books for all will use the same and parents will be saved the ex pense of present constant changes while the ; are relieved of all anxiety in regard to lit char : aeu r of the teachings under which their chil li r '. urs i rought this subject in all iis ! earings is of the iii '. 7 - ..',/.. ..-, o r fs . , h i ' .• ply countrvmen it is n i a sectional mov tent but a national . and patriotic one 1 is not a mi re rivalry be tween different pul li her . dr 1 wonld not pre sume to a-k your al i-i tion to it it goes down deep into our dearest interests ; it is tbe form ing of tilt minds of your children and mine which is at stake ; tin i loping of their self rtspeel and ch inn ter which is i ht tbe result it is an e-nti rprisi so im rtant to r.s that onr besl citiz our representative men in everv state to the number of '■'.' 0 and more the mi i we all honor and esteem — bav ; ut tiieir monev i ii:e work not lo mal i pruti out of ii al thotigh that is certain i ut tl idant means sl ild not be in king i ; the enti r prise on the largest sc lie will the teacher and i tbe south istain these atitli i -. hese ji :, lo in the woi k thus ii scribi . by adi ptinjj ing tbcsi to the i ion of all m i . mr answer i f yon dt sire further ini rmalien in n aid tn : the books write to • unit csity _ ' '..', g \ company 1-35 and 157 t rosby st new york — or 5-1 lexington sl . :• m or t meat atlanta ga and illustrated catalogues and ol her i ' n ti n will ent lo vou at . nee ! without ...:.. . . 12 3t t.b.gordon meroney & i.iiotiij.i i am attextl »> to 1 heir j ounary , • tl a . nm e jaop aad plaaiu - kill ssspthresh rs & horse-powers repaired bashes blinds and'doors made to order castings such s mill gearing gudgeons ttc v ill bell a lot of tobacco fixtures also a 15 horse power portable steam eno.no o t _____ now opening mnch the largest stock f gooth-t i ever offered iti this market and can buhl out greater inducements than ever to the wholesale and retail dealer with 20 years close experience in tin trade i think no denier will run any risk in giving mv stock a close examinution before making liis purchases either at wholes-tie or retail 1 call attention to a few leading articles which i will aid in reaching tho dit goods in a die various departments notions r»ady made clothing gents un der-wear rant goods hats and ' itiis bouts and siloes stationary wail aud curtain pi per bolting cloths — and rtttilf *•""■117 \ ijl _.!_■__.-, nails , sho 1 spades iron steel and castings rugs medicines paints oils of all kinds dye stuffs aud ' rocken • f f f*h tfk v-j v g usb *"**> e il£-&7 11 £___*$_? h coffee sugar molasses salt cheese soaps candles spices oi all kinds con fectioneries stiis dandies currants all complete in that line upper sole ain't harness leather 1 de heavily in all kinds whiskies awl brandies nd call your special attention to t j foster's old log cabin vvjjis ke . unsurpassed by any i am agent inr the famous watt plow wheeler millick & go's iiuiisiirpasseil thresher and cleaner at manufacturers prices v strict attention given to all orders i buy all kinds of s-*r ri h w u i 1 ip u 3 h 3 h lj cl j bb i 1 i f very thankful for the liberal patron age given uie in my busiaesa connections heretofore i hope to earn u continuance .'(' tin same mv sale men under present arrangements are : geo b bo.ti.tn m f hunt jno l burke m a vanderford moses l reed thos j foster no :_.' main street east ward ) salisbury n c ) 3:n:8 oct 3 1871 i jvotice £__ _?£..*_« 6--_.'y pistrict court of the v states l nor the cape fear district qf n cor linn ix i 7i;i 1-k v id the flatter of samuel rose bankrupt vtotice — this to give notice that a -"-^ petiiion inis been tiled by samuel grose of mecklenburg county in saitl dis trict court who has heretofore been l-.i!v declared a bankrupt upon the petit on ui creditors under the act of congress enti tled an act to establish :> uniform system of bankruptcy throughout the united states approved march 2d 1867 for a discharge and certificate thereof from all his debts and other claims proveablc under the said act and that on the 20th day of december 1871 at li o'clock a m in salisbury at the office of r ii broadficld cne ofthe registers of said court in bankruptcy at the time and place assigned for the hearing of the same when and where the creditors may attend and show cause it any they have why tho prayer oi the said petition should not be mted wm larkjns clk of the u s l)i>t court of said dist '• ll:2t:pd n^'oe to v 0xiees v in daui .. '- who have bad i'i ent and acceptance ';' i'i • ..'- 7 ■! have not paid b r •' ■• re ; . to forward amo n i * md oblige the editopt look ! litigants ! in pursuance of an order from the inver nor of north carolina a special term of the superior < auiri for the county of rowan for the trial ol civil causes will be held on monday the first day of january a li lc/2 at whi ti t.-rui of sai.l court parties an.l witnesses in all civil causes are liere by notified to appear and prosecute or de fend their suits d a.davis chairman county commissioners obadiah woodson clerk 10 tit cheap chattle mortgages and varioun ot*er blanks for sale here • • star cooking stoye the best and cheapest design ever yet invented witnesses on the ground whose experience prove it it is simple and ea bilymanaged it 1ms the largest oven of anv stove made in america other vari eties also on hand all sold cheaper than anv stove peddler can sell them and war ranted to perform well tin ware on hand and tin copper and sheet-iron work ofall kinds done to order with dispatch brown & weant meroney & brother dealers in d02ostic & fancy goods furnishing goods hosiery dress trimmings white goods boots slii.es hats cups groceries confectioneries c r>*"thev are agents for sewing machines agricultural implements ax " ranups & bros main street two doors above court-hov.se on sale fresh and salted fish of all kinds a full supply of family grocekies liquors and yankee notions also boots shoes hats caps domestics yarns __ crockery all going low for cash and country pro duce call and try them mar 24 wanted 100,000 lbs old bones vtwallace asks publie attention to his large & select 3tool of grootis comprising everything in the merc utile ! line and offered as chenp as the cheapest .' — his remaining winter stock at cost in which great bargains are daily given the high est cash prices paid in goods at the lowest rates for all kinds of country produce furs furs furs bring all your furs to wallace painting c s moring & son house digit & ornamental painters salisbury j ¥¥. bl 1 1 ina li main street salisbury ! wholesale & retail dcalsr iii general merchandise embracing all leading articles buys and sells all kinds of country produce wholesale liquor dealer and commission merchant — — agent for navassa guano co orders solicited r w price t j price i pexc3 & bro \ j[x have opexr v^a familv grocer ■_, jn the new building lately occ 1 by g smith selling a choice selection of ; j articles in tl me at greatly reduced prices . flour meal bacon butter lard c all fresh and sweet always ready coffees su guars and teas to suit the fancy bring your produce and trade with price & bro burton craige kerr craige craige & cbaxge ! attorneys at law jfo c council st/'eet opposite tht i ovrthouse practice in tin superior courts of rowan ar.d ad joining counties ; in the supreme court at raleigh and in the united states ircuit and district courts forthe dist of xorth ■i carolina march 23 1871 \ , i gf _?_!__ bs fill ji ! w dentist j office corner of church and inniss j streets salisbury 2 i wm m barker | ytbsr coach islaker §_________§_____ i menufactnring all kinds | of vehicles at his shop on lee street anv j one needing a mil iy good and fine job can | getithere call and see all work after the most approved patterns and v'l compare with any north or soul ii special attention invited to his light work and to his paint ing and trimming i7''0r:!'!*ue*.li*i and sign painting done with neatness and dispatch salisbury march 23 come to rooks !" the salisbury book store by j 1 stewart | is the place in gel books from a b c up wards until ymi can learn to lk n lan guages which few can understand — school books full series of all the most popular authors also auy amount of mil ies tes tament hymn docks vocal and instru mental music jycl»ia books copy books blank lllff^r books memo randums pens ti3i____r pencils papers writing and wall inks and ink-stand with a long catalogue of story books \ binghab * co sz&xf.jk wiii.i.ksai.i am retail : imgrocehs lk*"v i___e yiain st salisbury arc receiving a very large stock of ' salt sugar molasses bacon lard rice cheese candles oap powiier shot wilis brandy tobacco wot ware ro kery si ] llass ware and aii articles usually in i jrocery line which wc arc selling at wholesale and retail on tin most favorable ernis now i si ore 0 sacks coffee 30 bbls su_rar io boxes candles 80 " molasses 50 gross gail & ax's snpr scotch snnff p ' for sale low yo * ~ the very besl kerosei •■oil pure clarified cider vinegar pure candies raisens nuts cheese crackers corn starch hecker'a farina cox's gelatine de&icated cocoanajt j roval baking powders just received it bingham a co's ! john s hehder'oh gttorncs at sato salisldnry nf o mrs correll ~ thankfttl for pasl k*rors ha •' .. . . to announce thi | of hei of millinehy goo | hats bonnets chignons switcl j flowers bil ns o.c she is fn ' receiving additioi thus keeps on hand tin latest pier flowers ati very b ami see orders solicited done as usual store n lineally oppo ite n st an at ! as an wt sal ard be bo c i am ; rioi . tier kci j j j mt r i 3 ! can des ! blcs was recepl ii m chairs and pi : rustic windo :-::-.'' t.ai pleteness beaut . i ! ity also mail ol i.i ,' ar icles hicl ■pared to sell as cheap or cl liouse in the western i of state •?'- i !': oi . ....•!.: h sewood ie and wal lurial l -. v hich i . i furnished ; : • notice be sure to call . triy op osil ■* ii _ j sion iiu i ne t 1 office see . • and 1 special orders i in our offit t i v : : ! ed c f e 2 & co whole ■rs in tin sheet-iron and copper ware cook i and hii i - : i . of every size and quality stills repair 1 ed houst 5 roofed g i and 7 oi:t 1 all at short i work vai:i..i ed full c in store we cani t be highest pri es paid per j allen shown ml ... ■in ! grain flouk hai sal iscufty n c ' /• rder in ei ::;'. peri i7ja gl .:: ", and othi >: i rs also lime for building i - n eii a al u •■.-:-. office ai wm overm shoe t ore ■■i j allen wn insnitnc . y>epresents i ling ■*-*" and most n . ibi n ) ii i es both fire and life issues policies i iow est rates i ; " wm overman t self's sho 77 a k-___v ____&_& ix wash x ;. n^^c p labor v'v jy*fv " el £**#= '■'■■, * : v ' •* v-'i-d 1 • t^j 1 u*?i ---.-" ikmj r • \ ■• - ' - s vj - ■* - _ _ st d lor t'iiciir-ii v ". i ■list aitk 1 - wax i kd i wilson lockwood ever . . 1 hurra - . • 7 s in a t-i is '.. ■. ' .- . car . '■■j l 1 t c ._. " - fruit and ornamental 5«>i %-__.:__.__ <_' 1871 we invite thi -. . : to our la | stanilui 1 and duort t'i rape vii i ma uii • . ! ' ■x ai.tl iln buun riesci i.tiv . ■■. . t pr "_■.—'_> ' ' . v ___._.:_.! . _ __..-._ i •-■■•" . - irs 1 ; ge va;k v il - - . . 33 vv__i will a"i . a . agents 530 per dis rove ies if i and pleasant .-• ■; . ; dyelt v i v j i j a mllion bo 3 ph •'•■■<*. but , • ' - ■■•- - ■i vealing t1 e bci ret ol th bup'mei idi!ie.-.9 rrfl ; land deeds tra tee do commissioner's deeds deeds chattle mort . for sale it ifr
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Published: Apr. 21, 2011
Updated: Apr. 21, 2011
How do you say "thank you" to the doctor who gives you your life back?
I am a 54-year-old wife, mother, and full-time employee who has suffered from severe back pain for over 10 years.
Narcotics, pain patches, and muscle relaxants -- I was taking them all on a daily basis and still in severe pain, and yet my regional doctors could not find anything "wrong" with my back.
However, one visit to the Duke Spine Center and Dr. Carlos Bagley determined my problem and explained the operation that would correct it.
His expertise and calming manner in explaining the complex procedure left me with one question -- "Can you operate tomorrow?"
My spinal fusion for degenerative disk and scoliosis from my shoulder blades to my pelvis -- in which two titanium rods were inserted the entire length of my spine -- has given me a whole new lease on life. By four months after surgery, I was off all pain medications and back at work part time.
I live each day totally pain-free and free of the fog that accompanies narcotics. I cannot believe the freedom of life without pain or medications!
I praise God everyday for Dr. Bagley and his wonderful team for their continuous, compassionate care they provided before, during, and after my extensive surgery.
No human needs to suffer when there is help available at the Duke Spine Center.


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Syrian violence contributed to a sharp rise in the number of journalists killed for their work in 2012, as did a series of murders in Somalia. The dead include a record proportion of journalists who worked online. A CPJ special report
Syrian violence contributed to a sharp rise in the number of journalists killed for their work in 2012, as did a series of murders in Somalia. The dead include a record proportion of journalists who worked online. A CPJ special report
The Maria Moors Cabot Prizes, administered by Columbia University Graduate School of Journalism in recognition of journalistic contributions to Inter-American understanding, are the oldest international prizes in journalism. But Josh Friedman, director of the prizes, said this year marked the first time he remembered arriving at the awards ceremony to be greeted by protesters screaming from behind barricades. The tuxedo and gown-clad guests last night shot confused glances across the street from Columbia's Italian Academy building, where about 20 protesters brandishing Ecuadoran flags and pictures of President Rafael Correa yelled slogans like "Down the with corrupt press!" and "Long live President Correa!" One sign identified a long list of alleged "enemies of Latin American democracy" that managed to include the leading dailies of South America, the United States, Spain, the Ecuadoran press freedom group Fundamedios and the Committee to Protect Journalists.
Bogotá, October 4, 2012--The Committee to Protect Journalists condemns the exorbitant fine imposed upon a Quito newsmagazine for an opinion column related to a national referendum and urges Ecuadoran authorities to ensure that election regulations are not used to punish outlets for critical coverage.
Violence and legal harassment: the two greatest obstacles to press freedom in Latin America today. That's the message that CPJ Executive Director Joel Simon is delivering this morning in Washington, D.C., at a briefing hosted by Congressman Sam Farr. Farr, a California Democrat, hosts a monthly series looking at emerging trends in the Western Hemisphere. The panel today also includes Commissioner Dinah Shelton of the Inter-American Commission on Human Rights and Delphine Halgand of Reporters Without Borders.
New York, September 20, 2012--Ecuadoran authorities must immediately investigate threats against Janet Hinostroza, a journalist with the private network Teleamazonas, the Committee to Protect Journalists said today. The threats have forced Hinostroza to take a temporary leave of absence.
The Quito government's decision to grant Julian Assange political asylum comes at a time when freedom of expression is under siege in Ecuador. President Rafael Correa's press freedom record is among the very worst in the Americas, and providing asylum to the WikiLeaks founder won't change the repressive conditions facing Ecuadoran journalists who want to report critically about government policies and practices.
Bogotá, Colombia, July 3, 2012--Ecuadoran photographer Byron Baldeón was shot dead Sunday in front of his home in El Triunfo, about 60 kilometers (100 miles) north of the city of Guayaquil. The photographer had become a witness in a criminal case involving alleged police corruption, according to news reports.
New York, June 26, 2012--The Committee to Protect Journalists strongly condemns personal attacks made by Ecuadoran President Rafael Correa on Gustavo Cortez, editor of the leading daily El Universo.
CPJ has received an encouraging letter from Ambassador Maria Luiza Ribeiro Viotti, Brazil's permanent representative to the United Nations, affirming the country's support for the UNESCO-led U.N. Plan of Action for Security of Journalists and the Issue of Impunity.
On Sunday the general assembly of the Organization of American States will convene in Bolivia in the verdant, highland valley city of Cochabamba. The 35 member states (every nation in the region except Cuba) are expected to vote on a measure that, if passed, could curtail free expression and press throughout the hemisphere and put journalists and others at greater risk.
Stressing concerns of human rights groups about the deterioration of press conditions under the administration of President Rafael Correa, 17 members of the United Nations submitted recommendations to Ecuador on freedom of expression issues before the U.N. Human Rights Council this week. While Ecuador tried to pass off the criticism as resulting from ignorance, the states' observations made clear that the international community is fully aware of Correa's repressive tactics against the local media.
New York, February 27, 2012--Ecuadoran President Rafael Correa announced today that he would pardon several news managers and journalists he had sued for libel, but his actions in the cases have done grave damage to free expression in his country, the Committee to Protect Journalists said today. Correa had won separate libel complaints against executives of the daily El Universo and authors of the book The Big Brother concerning reporting critical of his administration.
In some Latin American countries, state-owned media are used not only for propaganda but as platforms to smear critics, including journalists. Some elected leaders have even invested in large multimedia holdings to further their agendas. By Carlos Lauría
The press freedom climate continued its sharp decline under President Rafael Correa. In September, a CPJ special report concluded that Correa's policies had transformed the country into one of the hemisphere's most restrictive nations for the press. In March, Correa brought a criminal libel complaint against senior managers of El Universo, the country's leading critical daily. The case, which centered on a biting opinion column that condemned Correa's actions in a 2010 standoff with police, resulted in convictions, prison sentences, and multimillion-dollar fines against the managers. The managers were free on appeal in late year. Other government officials also used the nation's archaic criminal defamation laws to try to silence journalists. The president made frequent use of cadenas, presidential addresses that pre-empt all private broadcast programming nationwide, to smear individual journalists and news outlets. Although cadenas have traditionally been used to deliver information in times of crisis, they have become a forum for political confrontation under Correa. The administration used other tactics to supplant independent voices with its own perspective, repeatedly ordering individual broadcasters to give over portions of their news programming to government "rebuttals." In a May referendum, voters approved ballot measures that would allow the administration to regulate news content in vaguely defined areas and force media owners to divest other holdings.
The sentence against Ecuadoran newspaper El Universo, its opinion editor, Emilio Palacio Urrutia, and its three top executives, Carlos Eduardo Pérez Barriga, César Enrique Pérez Barriga, and Carlos Nicolás Pérez Lapentti, for supposed offenses against Ecuadoran President Rafael Correa in Palacio's article "NO to lies," is a worn-out manifestation of the perverse concept of public freedoms that certain elected governments manipulate. They pervert their legitimacy with an authoritarian self-assuredness that permeates their exercise of power.
New York, February 16, 2012--Today's decision by Ecuador's highest court to uphold the criminal libel conviction brought by President Rafael Correa against El Universo represents a serious blow to freedom of expression and a setback for democracy, the Committee to Protect Journalists said.
New York, February 16, 2012--The Committee to Protect Journalists is outraged that Ecuador's highest court upheld today a libel conviction brought by President Rafael Correa against the Guayaquil-based daily El Universo.
New York, February 7, 2012--The Committee to Protect Journalists condemns the sentence handed to two Ecuadoran journalists yesterday after they were found guilty of defaming President Rafael Correa.
New York, January 31, 2012--Reforms to Ecuador's electoral law that will take effect on February 4 could hamper the ability of the country's journalists to cover political campaigns and elections, the Committee to Protect Journalists said today.
January 18, 2012
José Miguel Insulza
Secretary General of
the Organization of American States
1889 F Street N.W.
Washington, D.C.
Dear Mr. Insulza:
The Committee to Protect Journalists has been monitoring with increasing concern an offensive launched by the government of Ecuador aimed at weakening the Inter-American human rights system, an effort that if successful could represent a serious blow to freedom of expression in the hemisphere.
A controversial 2011 defamation verdict against the leading Ecuadoran daily El Universo, which became a symbol of vastly deteriorating press conditions under President Rafael Correa, appears headed to a final determination. The nation's highest court is due to hear the newspaper's appeal, although the hearing date itself is still subject to intense debate. The ramifications are enormous for free expression in Ecuador: The verdict, if upheld by the high court, could bankrupt the newspaper, put its managers in jail, and send a chill quashing dissent for years to come. As it fights for its existence, the paper has mounted an aggressive defense that includes an allegation that the trial judge allowed the president's own lawyer to write the verdict.


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Recent Success Stories
- Creative Scholar Preserves
Architectural Heritage - Kent State Hosts See You @
College Conference - Kent State Earns Tree Campus USA Designation for
Sixth Straight Year - Kent State's 12th Annual
Martin Luther King Jr. Celebration
Honors the Dream - Army ROTC at
Kent State
Commissions Officers - Scholar Fuels Students'
Knowledge of Technology - Congratulations to Our New Graduates
- Therapy Dogs Help Ease Stress of Finals Week
College of Podiatric Medicine Celebrates First Commencement Under Kent State
The Kent State University College of Podiatric Medicine, formerly the Ohio College of Podiatric Medicine, celebrated its first official Commencement as a college of Kent State on May 16, 2013. The Class of 2013 graduated 102 podiatric students from Kent State's College of Podiatric Medicine. The ceremony was held in the University Auditorium at Cartwright Hall on the Kent Campus in Kent, Ohio.
John Guiliana, D.P.M., a trustee of the American Academy of Podiatric Practice Management and adjunct professor at Kent State's College of Podiatric Medicine, gave a heartfelt, motivating commencement address to the Class of 2013. Guiliana also had the unique opportunity to see his son, Stephen Guiliana, graduate and follow in his father's footsteps of being a podiatrist.
Thomas V. Melillo, D.P.M., chief executive officer of Kent State's College of Podiatric Medicine, stated, "This was truly another major milestone in the history of the College of Podiatric Medicine. This class represents a new era of podiatric medical education under Kent State. I am very proud of our students, faculty and staff who have been instrumental in helping the college transition from the Ohio College of Podiatric Medicine to Kent State University College of Podiatric Medicine."
Kent State University's College of Podiatric Medicine, the largest podiatric medical college in the United States, is a four-year, graduate-level medical college, granting the degree of Doctor of Podiatric Medicine. The college's mission is to educate students to be highly competent doctors of podiatric medicine who will excel in residency training. Founded in 1916, the college has graduated more than 6,000 podiatrists who have made outstanding contributions to the field and study of podiatric medicine.
For more information about Kent State's College of Podiatric Medicine, visit www.kent.edu/cpm.
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There are many myths designed to tell you how you should wear your hair at your age. Were these ideals designed with "you" in mind, or are they generic rules that we are supposed to believe apply to all women your age? Wow, that'd be a lot of women with the same haircut!
Hairstylist to the stars Ken Paves offers some tips meant to influence, not restrict your own personal style. Ken says he believes that a woman's personal style evolves and changes as she embraces all that life has to offer her. "I find that many women I meet share many of the same personal goals at similar times in their lives, and I believe this influences their personal style," he says. No matter what your age, it is most important to stay true to yourself, Ken says. "These are merely suggestions that I have noticed along the way that make my clients feel confident and beautiful. Embrace the moment and don't hold onto the past. Feeling good about yourself gives you an incomparable glow that comes from the inside. Respect yourself and cherish every moment that has made you the beautiful woman you are today!" Hairstyles for… Advertisement
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1. Project Description
OpenRC is a dependency based init system that works with the system provided init program, normally /sbin/init. It is not a replacement for /sbin/init. OpenRC is 100% compatible with Gentoo init scripts, which means you can probably find one for the daemons you want to start in the Gentoo Portage Tree. OpenRC, however, is not exclusively used by Gentoo Linux, so our goal is to be platform-agnostic.
Related project: Gentoo Base System.
2. Developers
All developers can be reached by e-mail using firstname.lastname@example.com.
3. Documentation
4. Getting involved
The Gentoo OpenRC Project is open to all contributions. If you would like to get involved in the project, feel free to join us on irc/#openrc or even irc/#gentoo-base. We're also reachable via firstname.lastname@example.com. However, all bug reports should go through Bugzilla rather than e-mail. Please file bugs under the "Gentoo Hosted Projects" product and the "openrc" component.
You can also find the source code in the OpenRC git tree.
Page updated June 23, 2011
Summary: The Gentoo OpenRC Project manages Gentoo's initialization scripts system.
David Abbott Author William Hubbs Editor Mike Frysinger Editor
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Mousse in a Minute Recipe
To finish meal, I blend convenient canned lemon pie filling with whipped topping to make this dessert. It's light, tangy and a snap to whip up.Edna Shaffer, Beulah, Michigan
- 1-1/2 cups whipped topping
- 1 can (15-3/4 ounces) lemon pie filling
- 4 individual graham cracker tart shells or 1 graham cracker crust (9 inches), optional
- Shredded lemon peel, optional
- In a bowl, fold whipped topping into pie filling. Spoon into dessert dishes, tart shells or crust. Refrigerate until serving. Garnish with lemon peel if desired. Yield: 4 servings.
Originally published as Mousse in a Minute in Quick Cooking
January/February 1999, p20
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