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Funding opportunities
Stem cell-based strategies for treatment of Alzheimer's and other neurodegenerative disease
Funding Type:
Disease Team Planning
Grant Number:
Funds requested:
$54 952
Funding Recommendations:
Not recommended
Grant approved:
Public Abstract:
Alzheimer's disease (AD) is a progressive brain disorder that gradually destroys a person's memory and ability to communicate. AD is the most common form of dementia, currently affecting more than 5 million people in the United States. There is no cure for AD, and even the most effective drug treatments only temporarily delay the relentless progress of the disease. Ironically, since AD is a disease of aging, as therapies for other diseases improve and life spans increase, the number of people with AD is increasing. If this trend continues, in the next 50 years 16 million Americans will be afflicted with AD.
Stem cell therapies have been proposed for treatment of AD, but most scientists agree that cell replacement is unlikely to work because the damage is too widespread throughout the brain and involves too many different types of cells. We propose a stem cell therapy approach that doesn't require replacement of cells, but instead uses stem cells in two novel ways. First, we plan to use stem cell transplantation in a promising new method to deliver substances that protect neurons and help them to regenerate. Second, we will use nerve cells developed from human embryonic stem cells to screen drugs that are currently approved or in development for the treatment of AD.
The unprecedented team approach that we propose starts with a core group of five scientists: a clinician, a pharmaceutical researcher, an expert in creating transgenic mice for testing drugs, a basic researcher studying the molecules involved in AD pathology, and a human embryonic stem cell expert. All of the scientists are leaders in their respective fields and were chosen because they are all excellent collaborators and are excited about the opportunity to learn from the others. After a series of planning meetings among the core team members, a draft plan will be offered for discussion at an off-site meeting for the core team and additional experts, twelve people in all. Finally, the team will devise the best path to successful therapy that they can, using their combined expertise, and will draft a strategic plan to go forward with a formal team effort.
Statement of Benefit to California:
There are now nearly half a million people in California living with Alzheimer's disease (AD). AD is the most common form of dementia, currently affecting more than 5 million in the U.S; a new case is diagnosed in the US every 72 seconds (Alzheimer's Association.) Nearly half of all people over the age of 85 suffer from AD, and it affects one in eight of those over the age of 65. Ironically, deaths from AD have risen more than 30% in the last 10 years, a decade that saw decreases in deaths from heart disease, cancer, and stroke.
As life spans increase, the number of people with AD is increasing; in 2050 years 16 million Americans will be afflicted, The loss of productivity by the family members who care for AD victims costs California businesses $3 billion a year. More than a million people provide unpaid care to AD patients in California each year-as many as in Florida and New York combined. Their unpaid time has been valued at more than $8.5 billion. Nearly half of the nursing home residents in California, more than 100,000 people, have AD, costing the state and federal governments another $10 billion in Medicare and Medicaid each year.
AD is an incurable disease, and there are no therapies that can do more than temporarily reduce the relentless progression of nerve cell death and loss of memory. A therapy that could halt the disease would have immeasurable value; even if it is possible only to delay a person's decline by a year or two, the cost savings would be billions of dollars, and to a family of an AD victim, every extra year would be priceless.
Review Summary:
Executive Summary
Alzheimer's disease (AD) is the most common adult onset neurodegenerative disease affecting more than 5 million people in the United States. At present, there are neither cures nor effective therapies for the treatment of AD. The current application proposes to put together a clinically oriented research program using a suite of early stage and well developed technologies with the goal of developing a combination therapy strategy for improving memory and halting further progress of neurodegeneration. The investigators envision using stem cells (SCs) as a two track approach by first building on existing evidence that transplanting cells can aid in brain recovery by clearing amyloid plaques and delivering neurotrophic factors. The second track would then use SCs to speed drug development by incorporating human embryonic stem cells (hESCs) into toxicology and functional screens for drug candidates. This program is somewhat diverse and employs both an interventional approach with cell delivery as well as a somewhat unrelated in vitro approach.
Conceptually, this proposal targets two cell-based strategies for the treatment of AD and other neurodegenerative diseases. With the focus on AD, the proposal has high significance as it represents a major unsolved problem that is clearly an appropriate target for SC-based approaches. However, when comparing this application to other similar ones in this RFA, this proposal was not clearly defined. The proposal was felt to be overly broad, with both a drug screening and a cell therapy approach. Furthermore, although both approaches are novel, they do not share much in the way of overlapping biology, as the biology necessary for transplantation is quite different than the biology associated with in vitro screening. This breadth may be problematic for team assembly and to keep the project(s) on track. Reviewers agreed that the drug screening approach is more realistic than the engraftment therapy approach.
There was a consensus during the review discussion about the strength that the principal investigator (PI) brought to this application. The PI is an outstanding scientist with a very good track record in publications. The investigator proposes a core team that includes a neuropathologist with some clinical trial experience, a cell biologist, a pharmaceutical researcher with Investigational New Drug (IND) experience, an expert in AD models and assays, and an expert in establishing clinical trials in humans. None of these people however, have extensive experience in executing a large clinical trial. In that respect, reviewers thought the group would benefit from bringing in external advisors. Unfortunately, the core team is only loosely described, and there is little evidence in their description about the inclusion of an external advisory committee.
In terms of the planning approach, the review panel agreed that the main objective is poorly defined and seems to be in a development phase. The planning approach had major shortcomings, including lack of milestones, poor definition of the responsibility and mission of each of the members of the group, and a poorly-integrated collaborative approach. The proposal describes a planning meeting and conference calls that will lead to the draft strategy, and suggests the addition of other members who might be necessary during the first months; however, actual goals, plans, and structures of meetings remain unknown.
In summary, the panel felt that the proposal suffered from a lack of focus. The concept was overly broad and appeared very early in development. This was reflected in the planning approach, which was also judged to be in a development phase.
Reviewer One Comments
There are 2 approaches described in this proposal, a drug screening and a cell-replacement approach. The drug screening is far better and realistic than engraftment therapy. Although both approaches as noted in this limited description are novel, they do not share much in the way of overlapping biology as the biology necessary for transplantation is quite different than the biology associated with in vitro screening.
There is little experience with drug discovery in the proposed team. The plan is superficial.
The investigator proposes a team although this team is not well outlined. There is a core team that includes a neuropathologist with some clinical trial experience; a cell biologist; a pharmaceutical researcher with IND experience; an expert in AD models and assays; and an expert in establishing human research.
None of these people however, have extensive experience with putting together a large clinical trial and to that end would certainly benefit by bringing in external advisors far more experienced in this round. Unfortunately, the core team is only loosely described and there is little evidence in their description about the inclusion of an external advisory committee. Moreover, a more clear definition of the types of meetings, milestones that would be achieved by meeting periodically is missing in their disease planning approach. As compared to other disease planning applications, this one is far more superficial with thin details about actual goals, plans, structures of meetings, identifying local as well as more national experts in all of the rounds.
Reviewer Two Comments
- This proposal targets cell-based strategies for the treatment of Alzheimer's and other neurodegenerative diseases.
- This represents the second AD grant in this pile, and enjoys a very high significance as it represents a major unsolved problem that is clearly an appropriate target for stem cell-based approaches.
- The strength of the proposal includes, in addition to the significance of the project, the talent of the PI.
Principal Investigator:
- The PI got his/her PhD from the University of Oregon in 1979. He/She is an outstanding scientist with a very good track record in publications.
- 10% effort with salary requested.
- Moved in 2007 from Burnham Institute to Scripps Institute across the street.
- Team includes people from UCD, Torrey Pines Therapeutics, UC Irvine, and the Burnham Institute. The strength of the team is not at the highest level, certainly when compared with the other Alzheimer's proposal.
Planning Approach:
- This proposal was not as clearly defined as the others on the same topic in my pile, and there are major shortcomings, including lack of milestones, poor definition of the responsibility and mission of each of the members of the group, and a poorly-integrated collaborative approach.
- The main objective is poorly defined and seems that it still is in its development phase. During the first months, there will be planning meeting and conference calls that will lead to the draft of a strategy and suggest the addition of other members who might be necessary. The rest remains unknown.


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SOURCE ENERGYbits
Startup Gets Social with Sochi
BOSTON, Jan. 6, 2014 /PRNewswire/ -- In the days prior to social media, you had to be a large corporation or big advertiser in Times Square to make a big media splash. But thanks to the growth of social media, even a tiny startup like ENERGYbits® can now turn their passion for supporting their community into a big media success.
This Boston sports nutrition company wanted to honor athletes competing in the 2014 Winter Olympic Games. But like most startups short on cash, didn't have the bank account to fund an advertising campaign. So they used social media instead. The result is a month long social media campaign that kicks off January 6th with the company's Twitter header being transformed into an electronic billboard, reminiscent of Times Square. Each day throughout the month of January, the @ENERGYbits® Twitter header will feature an elite athlete training for the Winter Olympic Games, whose photo will be reposted on ENERGYbits® Pinterest, Instagram and Facebook. Each of the featured athletes is a Brand Ambassador with ENERGYbits® so they not only use ENERGYbits® algae tabs for their own training and competitions, they endorse taking them at high stake games like the Olympics.
Olympic athletes have relied on spirulina algae like ENERGYbits® for decades. While algae has been sold in the USA/Canada for fifty years, it remains virtually unknown here or worse, is considered pond scum. The reality couldn't be further from the truth. For decades, algae has been recognized as a nutritional powerhouse, prized by Olympic athletes like Lee Evans, a four-time USA track-and-field gold medalist, who back in 1968 was one of the first to attribute his success to algae, "spirulina algae improved my training, gave me speed and improved my endurance all of which resulted in my faster times."
Evans is not alone in crediting algae for his success. For decades, elite groups like NASA, the United Nations and Carnegie Institute have endorsed algae as the most nutritionally dense food in the world. And no wonder. It boasts the highest concentration of nutrients and protein in the world (three times that of steak). The lack of awareness of algae's nutritional profile is what motivated ENERGYbits® to be the first company to build algae into a national brand so it could be easier to understand and take. Athletes looking to improve their performance were the first to embrace ENERGYbits® tabs but now the word is out and consumers everywhere are taking ENERGYbits® to improve their health, stamina, focus and energy, all without caffeine, sugar, chemicals or gluten. Swallow a handful and you're good to go.
If you're going to the Olympics this year, be sure to pack ENERGYbits® to stay energized. If you need to purchase some, just visit www.energybits.com or look for the ENERGYbits® team who will be at the Olympic Games with samples, swag and banners that say "It's OK to Swallow". These tiny "bits-of-food" are sure to make you feel so great, you just might want to leap over tall buildings in a single bound. But try to leave that to the guys in the blue tights and red capes, or the athletes in Sochi.
View all ENERGYbits® athletes at http://www.pinterest.com/energybits/meet-our-elite-athlete-partners. Purchase your ENERGYbits® at www.energybits.com
Athletes Being Featured on @ENERGYbits®
Featured on
Chris Creveling
Short Track/Speedskating
Travis Jayner
Alyson Dudek
Nancy Swider-Peltz Jr.
Long Track/Speedskating
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January 16th-17th
Atsuko Tanaka
Ski Jumping
January 19th-25th
Alex Gough
January 6th-8th
Arianne Jones
January 9th-11th
Alexandrea Ianculescu
January 18th
David Morris
Freestyle Aerials
January 26-February 1
About ENERGYbits®
ENERGYbits® is a sports nutrition company that sells algae tabs to the professional sports, fitness and consumer communities. ENERGYbits® is a wholly owned subsidiary of Bits of Health, a five-year-old nutraceuticals company based in Boston, MA, USA. For more information or to purchase yours visit www.energybits.com or www.bitsofhealth.com
For more information:
Catharine Arnston Founder and CEO Bits of Health™ l ENERGYbits® 617-886-5106 Email
Read more news from Bits of Health.
©2012 PR Newswire. All Rights Reserved.


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Roger Vadim directs his ex-wife Brigitte Bardot once again in this conventional film about an innocent young woman, Genevieve (Bardot), who ends up on the losing side of a relationship with an alcoholic -- at least for awhile. Genevieve is a typical, introverted, middle-class woman who would like to be a homemaker and live relatively well. Instead, she goes to a small town to receive an inheritance, and by accident she walks into the wrong room in her hotel. And just in time. The alcoholic Renaud (Robert...more
All Love on a Pillow cast + crew photos


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Makes 1 cup / According to Traditional Chinese Medicine, greens cleanse and restore liver function; garlic boosts levels of detoxifying enzymes. Swirl a scoop of this tasty pesto into plain broth, spread on crusty whole-grain bread, or mix it with whole-wheat pasta.
6 cloves garlic 1 cup walnuts 2 cups (packed) fresh mustard greens, washed and dried 1/2 teaspoon garlic powder 1/2 teaspoon kosher salt 3 tablespoons extra-virgin olive oil
1. Place garlic in a food processor and mince. Add walnuts and process until finely ground. Add mustard greens, garlic powder, and salt and process until a thick paste forms. Slowly drizzle in olive oil and process until smooth.


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Crime Scene sells forensic supplies and detective clothing to the public. We are also home to an interactive detective game. | View Crime Scene Cases | |
Plastic SpatulaIdeal for use when mixing casting material, this flexible plastic mixing spatula washes easily. Customers who bought this product also purchased... |
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27 Donavon Lewis
09/29/2013 No. 25/23 Fresno State Holds Off Hawai'i'Dogs survive four second-half turnovers to defeat Hawai'i 42-37 06/20/2012 More `Dogs Earn Academic Accolades50 Fresno State student-athletes were named Academic All-WAC for the spring sports season. 12/07/2013 Fresno State vs. Utah State (USATSI)Fresno State vs. Utah State (USATSI) 11/23/2013 Fresno State vs. New Mexico, 11/23/13Fresno State defeats New Mexico 63-28 on Senior Day, 11/23/13 11/03/2012 Fresno State beats Hawaii 45-10The Bulldogs defeated Hawaii 45-10 09/29/2012 Fresno State vs. San Diego StateFresno State defeats SDSU 52-40 in Bulldog Stadium 09/15/2012 Fresno State vs ColoradoFresno State vs Colorado
2012 (Sophomore): Started all 13 games at outside linebacker ... tallied a total of 36 tackles and 28 unassisted tackles ... posted 10 tackles for a loss and four sacks on the season ... added one forced fumble, one pass breakup and three quarterback hurries ... recorded a season-best six tackles with two stops behind the line of scrimmage and one sack against SMU in the Sheraton Hawai'i bowl ... had four tackles against Tulsa and San Diego State ... against Nevada he posted two tackles for a loss of 15 yards ... had a sack and a forced fumble in the Nevada game that the Bulldogs were able to recover in the end zone for a touchdown.
2011 (Freshman): Appeared in every game as a true freshman, making two starts ... recorded 12 tackles (seven solo and five assisted) ... posted four tackles for a loss of 27 yards ... had 2.5 sacks for a loss of 18 yards ... recorded first career sack against California on Sept. 3 ... recorded a season-high two tackles four times on the year, the last being against San Diego State, a game in which he started ... his sack at SDSU was for a loss of nine yards ... also started the Sept. 24 game at Idaho and he finished that contest with two tackles and one tackle for a loss.
High School: Led Clovis West High School to the 2008 and 2010 Valley Championship ... as a senior, he was named the Valley Lineman of the Year, the Co-Defensive Player of the Year, selected first team All-Valley and played on the winning City All-Star team ... In 2010, he had 81 tackles and nine sacks to break the school record for most sacks in a career that was set by his brother ... in 2009, Lewis had recorded 52 tackles ad seven sacks .. as a sophomore, he had 68 tackles with 12 sacks and one forced fumble.
Personal: Personal: Born on April 3, 1993 ... son of Karen and James Lewis .. has one brother, Chris, and one sister, April ... his brother played at Fresno State in 2009 and 2010 and now plays for the San Jose SaberCats in the AFL ... his sister was a track athlete at Fresno State ... criminology-law enforcement major. Donavon Lewis' Career Stats Loading...


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Howling Wolf For My Mom Animals
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i love the texture of this wolf :D the expression is also very powerful! 5/5!
This is absolutely gorgeous, I love your technique! You draw wolves a lot the same as I do. I will have to get one of my wolf drawings up for you to see. Definitely faves!
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GameDB • Xbox 360 • The Last Remnant
Square Enix signs Unreal Engine 3 for "multiple" unannounced games
Square Enix Japan does deal with Gears of War maker.
News 17/11/2011 20
Square Enix: "one-console market is over"
Japan needs to "recognise" global audience.
News 20/11/2008 40
Square Enix reveals 360 release dates
Star Ocean, Last Remnant, Inf. Undiscovery.
News 10/06/2008 83
Squenix wants simultaneous global Last Remnant, FF dates
Feasibility being studied - CEO
News 11/07/2007 11


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This tutorial will instruct those with basic computer skills how to merge their Gmail account into Apple Mail 2.0-3.x in 10-15 minutes. YOU WILL NEE...
Open your desired your Internet Browser (Safari, FireFox, Google Chrome, etc).
Go to www.gmail.com and sign into your account.
Click the GEAR IMAGE on the TOP RIGHT CORNER of the website. - A drop down box of options will appear. -Click MAIL SETTIN...
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Click the bubble ENABLE POP FOR ALL MAIL.
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Exit out of the Internet Browser.
Open the APPLE MAIL APPLICATION . -The mail icon will be on your desktop. This looks like a postage stamp with an eagle on it. ...
Click Mail on the TOP LEFT CORNER of your screen. -Click PREFERENCES.
Click the tab Accounts. -Click the PLUS SIGN [+] AT THE BOTTOM LEFT OF THE WINDOW to create an account.
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Exit out of ACCOUNTS and PREFERENCES windows and return to the APPLE MAIL APPLICATION.
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VISION 2013 Cancelled, Show Moves to a Biennial Cycle
February 11, 2013
With a broad vote in favor of the new cycle, VISION 2013 will be cancelled and replaced by VISION 2014.


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ANJEL's Retrograde 34 Manga (Original)
Artist description:
Guys I don't know if it's just me or I might be losing my touch when doing effects for manga pages .__. I dunno maybe it's just the scene I'm doing right now lol. Anyway, I feel kinda bad for Yuuta since he doesn't even remember his parents :D
Created Mar 17, 2012. Unless noted Copyright 2012
Ms. Diary .
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Awww poor guy!!! D: And I think it still looks good even if theirs not much effects!
Oh me gee, if yuuta makes you want to cry you might want-to-cry of possibly cry a lot in this series c:
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W Hotel Minneapolis The FoshayDog-Friendly Hotels821 Marquette AvenueMinneapolis,Minnesota 55402Call 866-676-3077 To Book This Hotel Get Map or Directions In one soaring bastion of 1920's art deco splendor, your stay at W Minneapolis-The Foshay will be both legendary and cutting edge cool. No other skyscraper is listed on the National Register of Historic Places. With 447 feet of historical chic, the hotel presents 229 rooms, over 6,000 square feet of meeting space, Manny's restaurant, a sensational bar and our sensual W Living Room. You'll have everything you need to stay on top of the city's surging cosmopolitan scene. Featuring around-the-clock signature Whatever/Whenever service, the hotel infuses the city's historical architecture with modern culture and a fashionable attitude amid a flurry of edgy art, independent music, and thriving theater. From unwinding at SWEAT Fitness Center to wining and dining at our indulgent offerings, W Minneapolis - The Foshay flirts with your senses and meets every need. Known as the modern and hip twin to the more conservative and quiet St. Paul, Minneapolis is home to the financial district, just steps from The Foshay. You're also in the city's hot spot of architectural and cultural gems, such as the, the Walker Art Center, and the new Guthrie Theatre. If you're looking for more style and wild, the Mall of America and Minnesota Zoo are just a few miles down the highway. And don't worry about the infamous Paul Bunyan-caliber winters-miles of climate-controlled skyways mean you can work, shop, dine, and explore with having to brave the elements. We welcome cats and dogs 40 pounds or less. Guests must sign a waiver upon check-in and will be charged $25 per pet per day above the room rate. There is also a non-refundable $100 cleaning fee regardless of length of stay.In addition to offering numerous onsite amenities - including world class dining and a 27th floor observation lounge, this skyscraper hotel also sits amid an historic, cultural, and vibrant downtown community offering something for everyone. One dog up to 70 pound is allowed for an additional one time $100 pet fee plus $25 per day. Canine guests receive a custom pet bed to use, dinnerware with a mat, a pet toy, turndown treat, disposal bags, and a dog-walking service.
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Parents fight for release of son jailed in Mexico
MIAMI — A South Florida family is fighting to get their son, a Marine veteran, released from a prison in a dangerous area in Mexico while facing charges that he carried across the border a shotgun with a barrel that's an inch too short.
Jon Hammar and his friend were on their way to Costa Rica in August and planned to drive across the Mexican border near Matamoros in a Winnebago filled with surfboards and camping gear. Hammar, 27, asked U.S. border agents what to do with the unloaded shotgun, which his family said belonged to his great-grandfather.
"They examined it, they weighed it, they said you have to fill out this form," his father, Jon Hammar, told The Associated Press in a phone interview Tuesday from his home near Miami.
But when the pair crossed the border and handed the paperwork to Mexican officials, they impounded the RV and jailed the men, saying it was illegal to carry that type of gun. Hammar's friend was later released because the gun did not belong to him.
The family's attorney said Mexican law prohibits civilians from carrying certain types of guns, like sawed-off shotguns, which can be more easily concealed. Mexican law prohibits shotguns with a barrel of less than 25 inches (63.5 centimeters). Family attorney Eddie Varon-Levy said Mexican officials measured the barrel on Hammar's shotgun as 24 inches (61 centimeters). It has not been sawed off.
Family members said the gun was purchased at Sears and blamed U.S. officials for telling Hammar he could bring it across the border in the first place.
Varon-Levy also questioned the way Mexican officials measured the gun, because the measurements can differ depending on where they are taken on the barrel.
He said dealing with Mexican authorities has also been difficult. He said Hammar was brought to court a few weeks ago, where officials tried to convince him to plead guilty without a lawyer present. Varon-Levy said he didn't show up because he was told there was a continuance.
"I am fuming," he said.
Hammar could face 12 years in prison, but Varon-Levy said that's unlikely. He wants to get the charges downgraded, hoping Hammar can plead guilty to a lesser charge of carrying an unregistered weapon, which only carries a fine.


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About 16 years ago I was 34 and had suffered from nasal allergies my whole life. I woke up every morning stuffed and sneezing and never knew what it was like to not have at least one nostril stuffed up all day. Not to mention one dry nostril or both - ever.
We had a hot tub. I used bromine tablets to treat the water. They came in a tubluar continer and we were running low. I shook the container and like an idiot put my face close to the top to see if there was any more in the container. As I did that, the remaining powder residue poured out onto my face and I inhaled some in through my nose.
My nose felt like it was on fire. I flushed it with water and it was very irritated. I did not immediately seek medical attention because it did not feel that bad. It caused some nasal bleeding but it was minor.
The following few days after healing, I noticed a totally new experience, my nostrils were dry. Completely. I also was not stuffed up in the morning at all. I did not even sneeze around dogs or dust anymore.
I went to an allergist, told him what happened and he say I may have effected my nasal receptors.
It was amazing. It still is. I am 49 years old and still have my dry nose.
My 22 year old son suffers the exact same way I did. I often wonder if there is something less drastic that can cure this suffering for people.
I just wanted to share my story.View Thread
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Amaury Gutiérrez, Jotdog and More Set for Latin GRAMMY Pre-Telecast
Current Latin GRAMMY® nominee Pasión Vega, along with The Latin Recording Academy® President/CEO Gabriel Abaroa Jr. and Chairman of the Board of Trustees Luis Cobos will host the XIII Annual Latin GRAMMY® Pre-Telecast Ceremony (www.latingrammy.com), it was announced today by The Latin Recording Academy. Additionally, current Latin GRAMMY nominee Milly Quezada will present awards in select categories and current Latin GRAMMY nominees Amaury Gutiérrez, Jotdog, Gian Marco, and Cuartetango String Quartet, will perform at the Latin GRAMMY Pre-Telecast Ceremony, which is set for Nov. 15, from 1:30 – 3 p.m. PT at House of Blues inside theMandalay Bay Hotel & Casino in Las Vegas. Additionally, Latin GRAMMY En Vivo will feature a live stream of the ceremony (beginning at 1:30 p.m. PT) and the Latin GRAMMY green-carpet arrivals (3 – 5 p.m. PT) at www.latingrammy.com.
The Biggest Night in Latin Music, the XIII Annual Latin GRAMMY Awards® telecast, is set for Nov. 15 at the Mandalay Bay Events Center and will be broadcast live on the Univision Network (www.univision.com) from 8 – 11 p.m. ET/PT (7 p.m. Central). For updates and breaking news, please visit The Latin Recording Academy's website and its social networks on Twitter and Facebook: www.twitter.com/latingrammys, www.facebook.com/latingrammys.
The XIII Annual Latin GRAMMY Awards Pre-Telecast Ceremony will announce the winners in approximately 35 of the 47 Latin GRAMMY categories. The presentation takes place prior to the evening's telecast, kicking off a full evening of celebrating excellence in recorded Latin music from around the world. The Pre-Telecast will remain on demand at www.latingrammy.com for 30 days following the event.
Additionally, the Latin GRAMMY green-carpet celebrity arrivals will also be streamed live, and Latin Recording Academy Person of the Year red-carpet arrivals will be made available on demand providing music fans with special content, video interviews and photos. Please visitwww.latingrammy.com beginning at 1:30 p.m PT for live XIII Annual Latin GRAMMY coverage.
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- Cast of Las Vegas' JERSEY BOYS to Perform on THE QUEEN LATIFAH SHOW Tomorrow
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- VIDEO: Lifetime's THE TRIP TO BOUNTIFUL, with Cicely Tyson, Premieres Tonight
- Cast of Broadway's LES MISERABLES to Perform on ABC's GOOD MORNING AMERICA, 3/13


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Wine Loving Robot Scores World Record
The Tasting Robot, designed by NEC, has scored a 2008 Guinness World Record as the first robot sommelier (wine steward). The cute little bastard can "accurately assess a wine's type and ingredients by simply holding a sensor over the bottle". But he doesn't stop there, he can do the same thing for a lot of fruits and cheeses as well. Because let's face it, apples and bananas are often hard to differentiate. I was skeptical so I decided to really put the little guy to the test by tossing him in the cat's litterbox. Sadly the little bastard exploded. However his dying words did sound a lot like "oh shitâ€, which was correct.
R.I.P. Wine Loving Robot, you'll be missed homey. I'll pour out a little Cabernet Sauvignon in your memory as soon as I can afford a box.
NEC Robot Sommelier cracks open the Guinness records books [dvice]
This is The Inebriator, a robotic bartender capable of mixing preprogrammed (undoubtedly poisonous) cocktails by dispensing up to five different juices and nine different liquors. Just want a beer? TOO BAD. Want a cherry in your Mai Tai? NOT GONNA HAPPEN. Want to leave with... / Continue →
Wine: it makes you kiss all sloppy with your tongue and then the whole world spin until you wind up in bed without showering holding one hand against the wall and the other to the floor swearing to Dionysus you'll never drink again if you just don't puke. You'll pass out and n... / Continue →
Alcohol and power-tools, baby: God's combo. You wanna know what my problem with wine is? It isn't alcoholic enough. Sure if I take two bottles to the face the whole world starts spinning, but then what? Exactly, I almost drown in the bathtub. My neighbor already told me he'... / Continue →


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Homeowners can take small steps to reduce their carbon footprintsDec 28 2010 Homeowners can take small steps to reduce their carbon footprints Those who are searching for ways to decorate their homes in a unique manner could consider searching for cost-effective appliances and decorations. Lights that are powered with LED blubs will last longer and use significantly less energy, and home products such as floors and woven mats can be made from natural fibers like bamboo or wool. Soy-based candles will offer an eco-friendly way to scent the air. Homeowners should search for kitchen appliances that are energy-efficient When updating kitchens, individuals can make an effort to use dishwashers, clothes dryers and microwaves only when necessary. Those interested in minimizing their carbon footprints can install blinds such as honeycomb cellular shades. Blinds that trap heat in the winter and block the sun in the summer may reduce heating and cooling costs along with carbon emissions. Related Articles | (888) 633-7840 M-F 6am to 5pm Sat 6am to 3pm PST | |||||
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Search Rivier.edu
Welcome to your Rivier University Online Forms Center. You'll find documents pertaining to your academic and administrative responsibilities here at Rivier University in this central repository.
Please review the following forms to see if they apply to you:
Business Office
Financial Aid
International Students
Registrar's Office
Business Administration
Computer Science
Individualized Studies Program
Liberal Studies Program
We've gathered information and links that graduate/post graduate students may find useful; we hope that you will feel free to browse throughout. You can find information about your programs, links to specific portions of the Riv website, departmental information, administrative information, program sheets and more.Here is some common information you may need from time to time:


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Project Description
[from Arctic System Science Data Coordination Center home page, http://nsidc.org/arcss/] The Arctic System Science (ARCSS) Data Coordination Center (ADCC) at the National Snow and Ice Data Center, University of Colorado at Boulder, is the permanent data archive for all components of the ARCSS Program. Funded by the National Science Foundation's Office of Polar Programs, the project's focus is to archive and provide access to ARCSS-funded data. |


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Spurscast #212: Reviewing the Spurs' draft picks
In our draft review podcast, Jeff and I talk about Spurs' draft picks James Anderson and Ryan Richards. Though we both think Anderson will do a good job with the Spurs, we both felt Texas' Damion James was the better pick.
After talking about both players, we discussed the latest news including rumors that R.C.Buford was headed to the Portland Trailblazers to fill the job left vacant after Kevin Pritchard's firing, the possibility of Spurs' Assistant G.M. Dennis Lindsey to the Phoenix Suns, all the news surrounding Tiago Splitter, and Splitter in a Little Red Riding Hood outfit? All that and much more on this episode of the Spurscast.
The Spurscast. The first and orignial Spurs podcast!


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4dr Sdn Auto s Grand Touring
Starting at | Starting at 18 MPG City - 27 MPG Highway
The previous version of the MAZDA6 was already established as a fun-to-drive mid-size sedan. When the new, revised model went on sale in 2009, Mazda made the 6 especially spacious and safe, making the interior more luxurious and adding some new tech features.
The mid-size MAZDA6 sedan is unchanged for 2012.
The MAZDA6 comes in two different model lines, designated by their respective engines. Economy-minded 'i' models get a 170-horsepower, 2.5L 4-cylinder engine, while sportier 's' models come with a 272-hp, 3.7L V6.
Safety Ratings |
Driver Crash Grade |
Passenger Crash Grade |
Rollover Resistance |
Side Impact Crash Test - Front |
Side Impact Crash Test - Rear |
Braking & Traction |
4-Wheel ABS | Std |
Traction/Stability Control | Std |
Tire Pressure Monitoring System | Std |
Passenger Restraint |
Driver Air Bag | Std |
Passenger Air Bag | Std |
Passenger On/Off | Std |
Side Air Bag | Std |
Side Head Air Bag | Std |
Rear Head side Air Bag | Std |
Child Safety Locks | Std |
Road Visibility |
HID Headlights | Opt |
Fog Lamps | Std |
Electrochromic Rearview Mirror | Opt |
Intermittent Wipers | Opt |
Variable Inter. Wipers | Opt |
Rain Sensing Wipers | Opt |
Accident Prevention |
Back-Up Camera | Std |
Handsfree Wireless | Std |
Security |
Alarm | Std |
Anti-theft System | Opt |
Mazda Certified Pre-Owned Warranty |
Each Mazda Certified Pre-Owned vehicle comes with a 12-Month / 12,000 Mile Vehicle Limited Warranty with no deductible on covered components, which begins when the factory warranty ends. If it's out of warranty, the 12-month/12,000 miles warranty begins on the certified retail date. Coverage begins on the limited powertrain warranty from the original retail sales date and covers 7-Years /100,000 miles, whichever comes first. |
Age/Mileage Eligibility | 2008-2014 model years and less than 80,000 miles |
Lease Term Certified | No |
Point Inspection | 150-Point Detailed Inspection Autocheck® Vehicle History Report with 3-year buyback protection from Experian, subject to all Experian & Experian Automotive buyback terms and conditions. |
Return/Exchange Program | No |
Roadside Assistance | 24hr Roadside Assistance for the life of the Powertrain Limited Warranty offers confidence on the road around the clock. |
Special Financing | Yes, see your Mazda dealer for details. |
Transferrable Warranty | Yes |
Warranty Deductible | $0 |
Please enter your ZIP code to find vehicles for sale in your area.
Data on this page may have come in part, or entirely, from one or more of the following providers.


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BGSU Information Technology Policies
BGSU MyVPN Access Request Procedure
Applicability | BGSU Employees BGSU Employee Supervisor ITS Technology Support (TSC) Staff Members ITS Security Staff Members | Number | IT - xx - xx |
Last Revised | August 19, 2008 | ||
Policy Owner | Office of the Chief Information Officer firstname.lastname@example.com | ||
Governing Body | N/A |
The following procedure must be followed in order to obtain an account on the BGSU MyVPN.
- BGSU Employees
- BGSU Employee Supervisor
- ITS Technology Support Center (TSC) Staff Members
- ITS Security Staff Members
1. The supervisor of the employee needing access to the BGSU MyVPN will contact the Technical Support Center (TSC), 110 Hayes Hall to request access
email@example.com - or -
419-372-0999 - or -
2. The supervisor will need to provide TSC with the following information of the individual requiring access:
Name: | |
Email Address: | |
Phone Number: | |
Mailing Address: | |
Does the employee already have a Secure ID Token? | Yes No |
Purpose for BGSU MyVPN Access: | FMS |
| ITS Tech Support |
3. TSC will create an incident to document the access request. The incident will be assigned to the ITS Security Staff.
4. ITS Security staff will verify the account request.
5. If the ITS Security staff verifies that the account request is valid, the account will be created. The employee will be notified that their BGSU MyVPN account has been created and they will be provided with any appropriate instructions.
Additional statements related to BGSU MyVPN Access Request Procedure may be found in other policies issued by the Office of the CIO. See also BGSU MyVPN Policy , BGSU Information Technology Policy .
Once printed, this procedure may be outdated. The official procedure can be found at: http://www.bgsu.edu/offices/cio/page54483.html.
Printable pdf version of this document


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The late Ben Hogan said, "A good golf swing starts with a good grip." Whatever position you put your hands in on the golf club is the position the clubface will be in during your swing.
If you are a right-handed golfer, the left hand is the top hand and should be placed in a position where you can see two knuckles on the back of your left hand without moving your head. Everything that is said here is just the opposite for the left-hander.
The left thumb will be in the 1 o'clock position. The pressure points of the left hand will be in the last three fingers and the heel of your left hand. The amount of pressure should be about 5 or 6 on a scale of 1 to 10.
The right hand is your power hand and should be placed on the club with the palm of your right hand facing the target. I feel the right hand is more important than the left, as it dictates the position of the clubface at impact.
The left thumb should fit in the life line of the right hand with the little finger overlapping the index finger of your left hand.
The right thumb should be in the 11 o'clock position on the grip. The pressure from the right hand will be from the middle two fingers and about 4 or 5 on a scale of 1 to 10. This grip is called the Vardon grip or overlapping grip and is the most popular grip on the various professional tours. More than 90 percent of professionals use the Vardon grip.
The interlocking grip is with the index finger of the left hand and the little finger of the right hand interlocked together with the pressure points the same as the Vardon grip.
The full-fingered grip is used by people with very small hands with the hands in the same position and the pressure points the same as the other grips.
You will never master the game, but if you master the grip the game will become much more enjoyable.
Lee Martin is the director of instruction at River Ridge. He can be reached at 983-4653.


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Voice Platform and Support Network for Families of Missing and Victims of Crime
Started this discussion. Last reply by Tony Romeyn Oct 11, 2011. 5 Replies 1 Promotion
Started this discussion. Last reply by Tony Romeyn Mar 29, 2011. 5 Replies 0 Promotions
Started this discussion. Last reply by Tony Romeyn Mar 13, 2011. 3 Replies 0 Promotions
Tony Romeyn has not received any gifts yet
Added by Tony Romeyn 1 Comment 1 Promotion
Posted on January 15, 2013 at 12:11am 0 Comments 0 Promotions
Hello, Sara, Todd, Maureen, Jan and Larry,
A very belated Happy New Year. I pray all of you and families are well.
I have sort of been out of it somewhat, due in part to the events of last year and health not the best.
In the next few months I hope to turn over my Highway of Tears website to one of the Native Family Services Societies. I plan to also look for someone to take over my I am Missing website.
Not easy to do, I have put word out but not much…
ContinuePosted on November 2, 2012 at 1:54pm 1 Comment 2 Promotions
Hi there Denise, this morning I saw a news article on 1150 AM Radio News
The search continues for Charles Horvath-Allan
Wendy McLeod
Posted on May 22, 2012 at 12:03am 0 Comments 1 Promotion
Hello All, I wanted to share with you the ACTION BIBLE by David C Cook and Sergio Cariello.
It has about 720 pages, Old and New Testament. A lot of real Action Pictures, Comic type Bible, not meant for really young kids, more for early Teens and Up.
It is available as a Hard Cover Bible about $12 to $16 CAN. And an Audio Book as well, downloadable on your iPhone, iPad…
ContinuePosted on May 2, 2012 at 12:00am 1 Comment 1 Promotion
Just wanted to say HELLO to ALL of YOU at Peace4 The Missing, and SARA it is nice to see you back. I pray that God is Blessing you.
I am still fighting to be "Cleared"
It is my prayer that God would hold all those who are hurting because of a missing Loved One.
May He answer your prayers and comfort you through this horribly tough…
Posted on January 15, 2012 at 11:46pm 3 Comments 3 Promotions
Yes, I miss being here on Peace4 Missing a lot.
I wanted to re-share a poem I had written and posted early last year. I hope and pray that it will be meaningful to many of you.
I have a hard time keeping up with my personal websites, due to health. But YES God is good and keeps me…
ContinueHey Tony!
Thanks for getting back to me about the project! I understand about the photos. It is difficult to get them, as the rights belong to the families.
If you'd like to post it on the websites, I'd definitely appreciate it, as some of the family then may reach out themselves to take part. Please let me know if that would be something you'd do!
Thanks for your help,
© 2014 Created by Sara Huizenga.


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The Woodrow Wilson Center Press
Afghanistan and Pakistan: Conflict, Extremism, and Resistance to Modernity
Related Topics: Asia, Afghanistan
This timely study surveys the conflict in Afghanistan from Pakistan's point of view and analyzes the roots of Pakistan's ambiguous policy—supporting the United States on one hand and showing empathy for the Afghan Taliban on the other. The author, a former foreign secretary of Pakistan, considers a broad range of events and interweaves his own experiences and perspectives into the larger narrative of the Afghanistan-Pakistan relationship.
Beginning with the 1989 departure of Soviet troops—and especially since the 2001 NATO invasion—Riaz Mohammad Khan examines the development of Afghanistan and surveys the interests of external powers both there and in Pakistan. He discusses the rise of extremism and religious militancy in Pakistan and its links with ongoing conflicts in Afghanistan. Ultimately, Khan argues, Pakistan reveals a deep confusion in its public discourse on issues of modernity and the challenges the country faces, an intellectual crisis that Pakistan must address to secure the country's survival, progress, and constructive role in the region.
What People are Saying
".....an extremely important memoir-analysis by Riaz Mohammad Khan, a Pakistani diplomat who served as foreign secretary of Pakistan from 2005 to 2008. While sharply criticising some aspects of the Pakistani miltary's strategies regarding Afghanistan, he also brings out well the sheer intractibility of the Afghan situation, and the degree to which Pakistan too has been trapped by forces and developments beyond its control. It is exceptionally important that US policy makers read the book by (Riaz) Mohammad Khan, because there is strong tendency in US official circles and US media to treat the Pakistani state as the enemy in Afghanistan, and to assume that Taliban resistance in Afghanistan would largely disappear if Pakistan could somehow be bullied or bribed into submission. This misunderstands the deep popular sympathy on both sides of the border for the Taliban, who are seen among many Pakistani Pushtuns as a legitimate resistance force."—Anatol Lieven in The New York Review of Books
"This book offers an insider's extremely well-informed account of events in the Afghanistan-Pakistan region and an insightful perspective on history that is normally not available in academic books. Riaz Mohammad Khan has produced a serious piece of work but one that is also eminently readable."—Shuja Nawaz, director, South Asia Center, Atlantic Council
"The most compelling features of this book are the analysis of Pakistan's intellectual crisis and of the interests of various regional players in Afghanistan."—Ziad Haider, Harvard Kennedy School
Chapter List


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"Its bigger sister, the 2000 Haut-Brion (a blend of 51% Merlot, 43% Cabernet Sauvignon, and the rest Cabernet Franc) showed incredibly at the tasting, and for me is one of the three or four most prodigious wines of the vintage. A compelling nose of roasted herbs, scorched earth, sweet blueberries, plums, black currants, and a hint of graphite is followed by a deep, layered, sumptuously textured, full-bodied Haut-Brion, but one with extraordinary complexity. This wine seems more evolved and approachable than I had expected it to be at age 10. My window of maturity seven years ago was 2012-2040, but I would change that to 2010-2050. Haut-Brion can be among the trickiest Bordeaux to taste young, often needing a full decade before the extraordinary complexity that marks this terroir begins to emerge. I was thrilled to see how well both the second wine, Bahans Haut-Brion, and Haut-Brion performed in this tasting, and both scores are slight upgrades." 99 Points The Wine Advocate
"Full red-ruby. Roasted plum, currant, tobacco and minerals on the nose. Compellingly dense and thick but almost miraculously lively and light on its feet. Has a texture like liquid velvet, coating the entire palate. Wonderfully unmanipulated wine, with perfectly integrated acids giving it superb subtle vinosity and thrust. Finishes with outstanding building persistence, with the substantial tannins perfectly supported by the wine's fat middle." 96 Points International Wine Cellar
Château Haut-Brion is the oldest and by far the smallest of the "Premiers Grands Crus" vineyards of the Gironde 1855 classification. Château Haut-Brion is one of the few remaining family-owned domains of the Bordeaux region with a history going back to the 16th century. It has been owned by the American Dillon family since 1935.
(PEH-sak lay-ohn-yawn) One of the top appellations within Graves, Pessac-Leognan is home to the only Graves chateau listed as a first growth in the 1855 Medoc classification - Chateau Haut-Brion. In fact, praise for the chateau dates back to the days of Thomas Jefferson, when, upon visiting the chateau in 1787, he bought 125 bottles for his cellar in Virginia. Notable Facts The...Read More About Pessac-Leognan
Bordeaux Blends The Fab Five With so much history under its belt, it's no wonder that Bordeaux has figured out the recipe to produce amazing wines. Centuries of making (and drinking) wine led to the blend that has become synonomous with Bordeaux. Winemakers in the New World replicate this formula to create successful blends in their respective regions - you may see Bordeaux blends...Read More About Bordeaux Red Blends
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An active alum, Dan Goodman '01 is more like another teammate than a fan. He often stops by practice, attends games, and offers constant support to the team he says he looks to for support. Goodman was one of head coach Larry Anderson's first recruits and his close ties to the team offer inspiration to both sides.
On March 9, the same day that MIT took on Staten Island in the NCAA third-round, Goodman was in surgery at Massachusetts General Hospital to remove a malformation from his brain stem. Anderson says Goodman serves as an example of what it means to stay optimistic even through adversity, and the players say Goodman helps them focus on what's important.
Read Goodman's story on NCAA.com.


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Have you wondered why your child's report card does not reflect his/her potential? Or why he/she excels in certain subjects and not others? I specialize on helping people derive at the correct answer in any subject. Below is how I can help:With 11 years of experience tutoring and teaching, I can spot the tutee's challenges and overcome them. I started tutoring in 9th grade in a school-sponsored peer tutoring program, 10 hours/week. I tutored pretty much everything, from pre-algebra to pre-calculus, from ESL to AP English, and all the required social sciences (and AP US History). During my college years at UC Berkeley, I tutored 15+hours/week. My marketing thing was "Get A for the test, or your money back." While I tutored a variety of subjects, I specialized on social sciences and business essay writing: to put your insights on paper concisely and interestingly - to get a WOW and an A+. The more I tutor, the more I realize that people are very intelligent - they just have three fundamental challenges that prevent them from excelling:This is a negative feedback loop because the more they believe they are bad at a subject, the less time they spend on it and the more pain they feel while actually studying it. For instance, Bill, one of my Calculus tutee. Bill believes that he's an excellent writer, but somehow he is "dumb" at math. So I asked him: "How do you know you are dumb at math?" "Because I had a D on my last midterm" Bill Replied. I went: "Did you know Einstein failed at Math as a child?" Bill was taken completely by surprise. I continued: "Math is about practice; it has nothing to do with your intelligence. It's like sports (Bill is a football player), the more you practice with your problem set, the more natural it is to you." Then we just methodologically "Blitz" through the problem set, one by one. Bill became very confident and aced the final. I can help get rid of those deadly mental blocks in any subject.+No time management/prioritizing skill: People do badly in school because they have wrong priority while studying. I had an observation at Cal: The B and C students spend hours going through the material and frequently miss class. The A students show up in class, take notes, ask questions, and spend much less time studying at home. Consequently, they spend less time study, understand the materials better, and get A's. In addition to the content I tutor, I also add in advice about active listening, asking questions, how to take good notes, and minimize study hours and maximize learning. +No definite long term goals: A+ students who take 4 AP Classes a semester, in 5 extracurricular activities in addition to sport team and student government aren't super human. They just have high motivation and definite goals that they want to achieve. I noticed this in high school, at Cal, and at my work-I am an executive for a high-tech start up in the Bay Area. I noticed that the top learners and earners ask this question: "Why do I do this? If it's done, how would I feel and how would my life be if I consistently achieve these goals?" Relate this to tutoring, I love playing this vision building exercise with my tutee: "If you have an A in class, would it affect your chance of getting into great college?" (YES) "If you get into a great college, would you make more money and have better connections than someone who doesn't?" (YES)"Wouldn't having a prestigious degree make you look good and allow more options for your job?" (YES) "Would it then make your life more comfortable and allow you more chance of doing what you love, instead of worrying about money and paying the bill everyday?" (YES) "You hate being broke and looked down by people do you?" (YES) "I understand. I feel the same. Let's make a goal of completing these problem sets by Wednesday and get an A on the next midterm. I'm not just a tutor, I help with setting definite goals and finding the reason those goals are important as well. If you are looking for someone to help with not only the subject matter at hand, but to inspire a love of learning, I'm your man. Here's a quick summary of my credentials (for additional peace of mind):-Eleven years of tutoring experience.-Bachelor of Arts from UC Berkeley (Business and Political Science).-Perfect score on GMAT Writing.-Founder and Lecturer at Berkeley City College's Study Skill Workshop.-Former President of UC Berkeley's Toastmasters International (I coached people doing the scariest thing in the world-Public Speaking)-I have excellent people skill, I can relate with and motivate my tutees to aspire to be a life long learner.
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I am fluent in English and Vietnamese, College-level french. I am currently learning Chinese, so I understand the difficulty of learning new languages and know how to overcome them from experience. I tutored TOEFL in the past, and tutored a total of 5 international students before.
I am the Former President, and a member of Toastmasters International-UC Berkeley Branch for 2 years. I've help coach 10+ people who are terrified of public speaking to give the first speech in the club.I was a Founder and Lecturer at Berkeley City College Study Skills Workshop. One of the skills I taught is confidence and mindset, which are critical components of public speaking.I was also Director of Business Development, at Specialdeals. I trained and lead a Specialdeals... Read More
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When I run into Sophie coming through the thick fog, I am uncertain whether she is a real person or a figment of my own imagination.
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In West Babylon two lanes blocked on The Southern St Pkwy WB between Belmont Ave/X37 and before Straight Path/X36 in Amityville In West Babylon two lanes blocked on The Southern St Pkwy WB between Belmont Ave/X37 and before Straight Path/X36 in Amityville In Brookville closed due to accident on North Broadway Both NB/SB at Hwy 106/Newbridge Rd and ... (more)
Suffolk bill would let sheriff fill positions
Suffolk County Sheriff Vincent DeMarco stands in one of the four pods at the new Suffolk County Correctional Facility in Yaphank.
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February 28, 2014 - Suffolk County Police First Squad detectives are investigating a single-car crash that killed a woman in Amityville early this morning.
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This file photo shows the detective shield and patch of the Suffolk Police Department on Oct. 26, 2009 in Yaphank.
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A majority of Amityville's trustees have signed a letter seeking to cap the pay of top-earning officers in the village police department, a move they say would save $800,000 over the four years remaining in the current contract.
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Taking Back Sunday is set to play at Revolution Bar and Music Hall in Amityville, N.Y., on Apr. 14. The special performance is courtesy of Looney Tunes , a record store located in West Babylon.
Meeting to present NY Rising's rebuild in Babylon Town
Proposals for rebuilding storm-damaged infrastructure and revitalizing six Babylon Town communities hit hard by superstorm Sandy will be presented at a New York Rising Community Reconstruction Development Program meeting Monday in Lindenhurst.
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Babylon Town officials are considering proposals to build at a North Amityville intersection, shown on Feb. 21, 2013, infamous for its open-air drug trade.
Powerball jackpot winning numbers drawn: 02-09-14-21-23
A sign at the U. S. Petroleum gas station on Route 110 in North Amityville shows that the current Powerball jackpot is up to $330 million on Saturday, Feb. 15, 2014.
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Kings Park High School at 200 East Main St. houses students grades 9 through 12. It is the only high school in the Kings Park Central School District.
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Mar. Drugs 2012, 10(10), 2349-2368; doi:10.3390/md10102349
ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels
CSIRO Materials Science and Engineering, Bag 10, Clayton South, Victoria 3169, Australia
Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia
Health Innovations Research Institute, RMIT University, Melbourne, Victoria 3083, Australia
Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia
School of Chemistry, Monash University, Clayton, Victoria 3800, Australia
Current address: Faculty of Science and Technology, Deakin University, Locked Bag 20000, Geelong, Victoria 3220, Australia.
* Authors to whom correspondence should be addressed.
Received: 12 September 2012; in revised form: 10 October 2012 / Accepted: 12 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Marine Peptides and Their Mimetics)
Download PDF Full-Text [866 KB, uploaded 22 October 2012 16:01 CEST]
Abstract: The neuronal voltage-gated N-type calcium channel (Cav2.2) is a validated target for the treatment of neuropathic pain. A small library of anthranilamide-derived ω-Conotoxin GVIA mimetics bearing the diphenylmethylpiperazine moiety were prepared and tested using three experimental measures of calcium channel blockade. These consisted of a 125I-ω-conotoxin GVIA displacement assay, a fluorescence-based calcium response assay with SH-SY5Y neuroblastoma cells, and a whole-cell patch clamp electrophysiology assay with HEK293 cells stably expressing human Cav2.2 channels. A subset of compounds were active in all three assays. This is the first time that compounds designed to be mimics of ω-conotoxin GVIA and found to be active in the 125I-ω-conotoxin GVIA displacement assay have also been shown to block functional ion channels in a dose-dependent manner.
Keywords: Cav2.2; conotoxin; peptidomimetics; radioligand binding; Ca2+ fluorescence assay; patch clamp electrophysiology
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Click here to load and display the download statistics.Cite This Article
MDPI and ACS Style
Tranberg, C.E.; Yang, A.; Vetter, I.; McArthur, J.R.; Baell, J.B.; Lewis, R.J.; Tuck, K.L.; Duggan, P.J. ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels. Mar. Drugs 2012, 10, 2349-2368.
AMA StyleTranberg CE, Yang A, Vetter I, McArthur JR, Baell JB, Lewis RJ, Tuck KL, Duggan PJ. ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels. Marine Drugs. 2012; 10(10):2349-2368.
Chicago/Turabian StyleTranberg, Charlotte Elisabet; Yang, Aijun; Vetter, Irina; McArthur, Jeffrey R.; Baell, Jonathan B.; Lewis, Richard J.; Tuck, Kellie L.; Duggan, Peter J. 2012. "ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels." Mar. Drugs 10, no. 10: 2349-2368.
Mar. Drugs
Published by MDPI AG, Basel, Switzerland
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There's nothing quite like California Almonds to add a premium and sophisticated touch to your latest recipes and formulations. They add so much more than just subtle, buttery taste and sought-after nutrition. They're also chock-full of value, versatility, and variety—making it almost impossible for consumers around the world to resist them. So, serve up your next dish or product with an extra dose of appeal. Make almonds part of the equation.
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"Great Service, price and experience. THANKS KEVIN!"
Return with single pedestal must be used with right-pedestal desks, desk shells, peninsulas or corner units in the HON 10500 Series Wood Laminate Furniture, a versatile collection for any office arrangement. Smooth, flat edges and a full modesty panel deliver a clean look. Scratch-resistant, spill-resistant and wear-resistant, Harvest laminate on strong inner-frame construction assures trouble-free performance and long life. Return features one full pedestal on the left with two locking file drawers that include integrated hangrails for side-to-side letter-size and legal-size folders and front-to-back for letter-size filing. Five-sided drawers operate on full-extension, ball-bearing suspension to ensure smooth, long-lasting operation. Non-freestanding return also has one worksurface grommet and one cord pass-through grommet in the top center of the modesty panel to reach wall electrical outlets and interchangeable, core-removable lock for quick and easy rekeying.


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Best-in-class standard diesel 800 lb.-ft. of torque and 400 horsepower.* Plus excellent fuel efficiency to go with all that power.** B20 capability and clean, quiet operation too. That's the Ford-built 6.7L Power Stroke® V8 Turbo Diesel. The Power Stroke features a graphite iron engine block that is stronger yet lighter than cast iron. Aluminum cylinder heads with precision dual water jackets reduce weight and improve cooling. Inboard exhaust and outboard air induction architecture helps reduce turbo lag. The class-exclusive† single-sequential turbocharger uses the compact, efficient design of a dual-sided compressor wheel to help generate maximum power - and deliver it quickly with 30 psi of boost. Another great feature is the high-pressure common-rail induction system which, operating at nearly 30,000 psi, delivers up to five injections per combustion cycle for optimum throttle response and fuel efficiency, as well as reduced noise, vibration and harshness (NVH). What's more, the Power Stroke is equipped with instant-start glow plugs for quick start-ups, even at extremely low temperatures.
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PastaBAR Hours PastaBAR, a simple name for a simple idea. Great food, great drinks in a great surrounding. What makes PastaBAR unique is the fact there aren't a lot of places doing these simple things well. Simply exceptional. PHILOSOPHY The best way to make a quality product is to infuse quality at every chance. This includes steps taken well before any food hits the pan. Menu planning, wine selection, judging flour, cheese, anything that unifies the theme; Simply Exceptional. At PastaBAR we use only the finest ingredients, matched with distinctive flair for an unmatched result. Only the best makes it to our kitchen, and from that... to you. MENU »Download PDF menu
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Struggling to Adapt
Webmaster ~ December 20th, 2011
Looking back at our blog, we've had an interesting year: Tornadoes, earthquakes, hurricanes and then a freak pre-Halloween snow storm that resulted in long term black outs.
I was certainly more prepared for the snowpocalypse than the last few curve balls thrown at us by Mother Nature. My husband and I were lucky enough to have family we could stay with. We went on a mini vacation until things started to improve near our house. Then we headed back so my husband could go to work as his office had power. We came back even though the Dynamic Living office and our apartment were still without power. I figured I'd be fine. And I was…. Sort of.
Every now and then I'd catch myself thinking "oh I'll just plug that in…" or "I can turn that on…" Except that plugging things in or turning things on wasn't going to do much. As one friend put it: I'd make a crummy pioneer. If the power had stayed out longer I would have eventually gotten used to it. I kept myself busy and found ways to adapt to not having power. Looking back I realize the whole experience is very similar to what happens when you have an injury or an illness that heaves your daily routine right out the window.
At first, we were shocked. We didn't know what to do, so we went looking for help. We had to leave the comfort of our own home so that we could just have the basics that we needed to survive. We also needed help from family and friends. We came home once we were feeling a little more secure about what we needed to do. After we got home, I went through the process of adapting our apartment for the current situation and made sure we had enough gadgets to supplement those adaptations.
My husband and I were able to get back to normal fairly quickly, but not everyone got power back in a timely manner. While we were putting things back they way they were, many people in our area were looking at adaptations that could last a longer.
The whole experience was a reminder for me that I take many things for granted. For example, the ability to walk around my apartment safely after the sun sets is something I came to appreciate in those days. So now that we're back to "normal" I've left many of those adaptations as they were. If I take them down, I'll have to start over the NEXT time the power goes out. Being prepared for it will make the already stressful situation a little easier to cope with.


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By Mr. Smizik of Brookline, a petition (accompanied by bill, House, No. 2027) of Frank I. Smizik and others relative to the licensure of professional landscape architects. Environment, Natural Resources and Agriculture.
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Petitioners: Frank I. Smizik, James J. Dwyer, Jennifer E. Benson, Sal N. DiDomenico, Alice K. Wolf


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Tray dimensions: 38" x 24"
Height: Approximately 61"
Weight: Approximately 75 lb.
Java wood is one of the only bird safe, hard woods that actually grows horizontally making great climbing wood bird stands for parrots. That means that you are getting a "real" tree style wood bird stand rather one that has been cut to size and screwed together. You'll find that Java Wood Bird Stands are much sturdier and that the branches never loosen like man-made trees or Manzanita Bird Stands. Each Java Wood Bird Stand has it's own unique formation and the one you receive may look different from the picture.
Java Wood Bird Stands are truly a five star bird gym! Each bird stand has a unique branch structure that has been pruned to make an optimum climbing and play experience for the size of parrot you are purchasing the bird stand for. Java Trees grow in such unique configurations that the climbing surface is one piece and one of a kind. Further, each tree trunk is individually fitted large tray to minimize your parrot pooping over the side and on the floor. The tray is sealed with a non-toxic, water-proof finish.
Assembling the Java Wood Bird Stand is quick. Just secure the tree trunk to the base with three long bolts and slide the top canopy onto the trunk.
These bird stands come with 2 bowls and 2 eye style toy hooks.
Shipping Information: This Java Wood Bird Stand can ship via UPS.
Flat rate shipping in Continental U.S. is $165.00


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