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Marisa Tomei
Marisa Tomei | |
Tomei at the Inescapable premiere, 2012
Born | Brooklyn, New York, U.S. |
December 4, 1964
Residence | Greenwich Village, New York |
Occupation | Actress |
Years active | 1984–present |
Marisa Tomei (/məˈrɪsə toʊˈmeɪ/; born December 4, 1964) is an American stage, film, and television actress. Following her work on As The World Turns, Tomei came to prominence as a supporting cast member on The Cosby Show spinoff A Different World in 1987. After she had appeared in a few films, her breakthrough came in 1992 with the comedy My Cousin Vinny, for which she won the Academy Award for Best Supporting Actress.
Of the many films she appeared in over the past fifteen years, her most commercially successfu to date are What Women Want (2000), Anger Management (2003), and Wild Hogs (2007).[1] She received critical acclaim for her performances in Unhook the Stars (1996), Slums of Beverly Hills (1998), and Before the Devil Knows You're Dead (2007) and received Academy Award nominations for her performances in In the Bedroom (2001) and The Wrestler (2008).[2]
Life and career[edit]
1964–83: Early life and career beginnings[edit]
Tomei was born in Brooklyn, New York, the daughter of Patricia Adelaide "Addie" Tomei (née Bianchi), an English teacher, and Garrett A. Tomei, a trial lawyer.[3][4] She has a younger brother, actor Adam Tomei, and was partly raised by her paternal grandparents, Rita and Romeo Tomei.[5] Both of Tomei's parents are of Italian descent. Her maternal grandmother is from Sicily, Tomei's maternal grandfather is from Tuscany, and her father is also of Tuscan descent.[6][7] Tomei grew up in the Midwood neighborhood of Brooklyn.[8] While there, she became captivated by the Broadway shows her theater-loving parents took her to and drawn to acting as a career. At Andries Hudde Junior High School, she played the part of Hedy LaRue in a school production of How to Succeed in Business Without Really Trying. After graduating from Edward R. Murrow High School in 1982, she attended Boston University for a year.[5]
1984–2002: Breakthrough and critical success[edit]
Tomei followed up As the World Turns in 1986 with a role on the sitcom A Different World as Maggie Lauten during the first season. Her film debut was a minor role in the 1984 comedy film The Flamingo Kid, with Matt Dillon. Following several small films, her breakthrough comedic performance came in the 1992 film My Cousin Vinny,[9] for which she received critical praise. Critic Vincent Canby wrote, "Ms. Tomei gives every indication of being a fine comedian, whether towering over Mr. Pesci and trying to look small, or arguing about a leaky faucet in terms that demonstrate her knowledge of plumbing. Mona Lisa is also a first-rate auto mechanic, which comes in handy in the untying of the knotted story."[10] For her performance, Tomei was named Best Supporting Actress at the 1993 Academy Awards, prevailing over Miranda Richardson, Joan Plowright, Vanessa Redgrave and Judy Davis. American film critic Rex Reed created controversy (and a minor Hollywood myth)[11][12][13] when he suggested that Jack Palance had announced the wrong name after opening the envelope.[14][15] While this allegation was repeatedly disproved[16][17] – even the Academy officially denied it[18] – Tomei called the story "extremely hurtful." A Price Waterhouse accountant explained that if such an event had occurred, "we have an agreement with the Academy that one of us would step on stage, introduce ourselves, and say the presenter misspoke."[19]
After her Oscar win, Tomei appeared as silent film star Mabel Normand in the film Chaplin, with her then-boyfriend Robert Downey Jr. playing the title character. The following year she starred in the romantic drama Untamed Heart with Christian Slater, for which they won the MTV Movie Award for Best Kiss. Tomei had won the previous year for Best Breakthrough Performance for My Cousin Vinny. The following year Tomei appeared alongside Downey again in the romantic comedy Only You. She then appeared in Nick Cassavetes's Unhook the Stars opposite Gena Rowlands. Of Tomei's performance, The New York Times wrote, "Ms. Tomei is equally fine as Mildred's younger, hot-tempered neighbor, whose raw working-class feistiness and bluntly profane vocabulary initially repel the genteel older woman."[20] She received her first Screen Actor's Guild Award nomination for Outstanding Female Supporting Actor for her performance. In 1998, she received an American Comedy Award nomination for Funniest Supporting Actress for Tamara Jenkins's cult film Slums of Beverly Hills, in which she appeared alongside Natasha Lyonne and Alan Arkin. The independent film was well received by critics and the public.[21] The New York Times writes, "Jenkins makes the most of an especially ingratiating cast, with Ms. Tomei very charming and funny as Rita"[22] while another critic states Tomei is "spunky and sexy, . . . more subdued than she usually is."[23] Tomei spent several years away from high-profile roles and major motion pictures in the late 1990s, before rising again to prominence in the early 2000s.[24] Tomei appeared in the 2000 film What Women Want with Mel Gibson and Helen Hunt, which was a commercial success, and had a supporting role in the romantic comedy Someone Like You with Hugh Jackman and Ashley Judd.
In 2001, Tomei appeared in Todd Field's Best Picture nominee In the Bedroom opposite Sissy Spacek and Tom Wilkinson, earning several awards including a ShoWest Award for Best Supporting Actress in 2002. Variety wrote, "Tomei is winning in what is surely her most naturalistic and unaffected performance,"[25] while The New York Times writer Stephen Holden exclaimed, "Ms. Tomei's ruined, sorrowful Natalie is easily her finest screen role."[26] In the Bedroom earned Tomei a second Academy Award nomination and her first Golden Globe Award nomination for Best Supporting Actress. Tomei also shared a Screen Actors Guild Award nomination for Outstanding Performance by a Cast. In 2002 she appeared in the Bollywood-inspired film The Guru and voiced the role of Bree Blackburn, the main antagonist in the animated feature film The Wild Thornberrys Movie.
During the 1990s, Tomei made several television appearances. In 1995, she made a guest appearance on the sitcom Seinfeld, playing herself in the two-part episode "The Cadillac." In the episode, George Constanza attempts to get a date with her through a friend of Elaine Benes. She also made an appearance on The Simpsons as movie star Sara Sloane, who falls in love with Ned Flanders. Former Saturday Night Live cast member Jay Mohr wrote in his book Gasping for Airtime that, as guest host in October 1994, Tomei insisted that a proposed sketch, "Good Morning Brooklyn," not be used because she did not like the idea of being stereotyped; that stand displeased the writers and performers, given the show's penchant for satirizing celebrities.[27] Tomei did however, parody her role from My Cousin Vinny, which had considerable Brooklyn influence, in a skit (out of several recurring) spoofing the 1995 O.J. Simpson murder trial.
In 2003, Tomei appeared in one of her biggest commercial hits, Anger Management. The following year, she appeared in the film Alfie based on the 1966 British film of the same name, opposite Jude Law. In 2005, she was featured in an ad campaign for Hanes with the slogan "Look who we've got our Hanes on now", featuring various other celebrities including Michael Jordan, Jennifer Love Hewitt, Damon Wayans, Matthew Perry and, on Spanish-language advertising, Aracely Arámbula and Pablo Montero. In 2006, Tomei had a recurring role on Rescue Me, playing Johnny Gavin's ex-wife Angie. She won a Gracie Allen Award for Supporting Actress in a Drama Series for her work in the four episodes she appeared in. The following year she appeared in the comedy Wild Hogs alongside John Travolta, Tim Allen, William H. Macy and Martin Lawrence. The film was the 13th highest-grossing movie of 2007 ($168,273,550 domestic box office). She also starred in the Sidney Lumet-directed Before the Devil Knows You're Dead opposite co-stars Philip Seymour Hoffman and Ethan Hawke. The film was released to critical acclaim.
In 2008, Tomei played Cassidy/Pam, a struggling stripper, in the Darren Aronofsky film The Wrestler opposite Mickey Rourke. She appeared in several nude dance numbers in the film. On working with Tomei, Aronofsky said, "This role shows how courageous and brave Marisa is. And ultimately she's really sexy. We knew nudity was a big part of the picture, and she wanted to be that exposed and vulnerable."[28] Numerous critics heralded this performance as a standout in her career. The Hollywood Reporter wrote, "Tomei delivers one of her most arresting performances, again without any trace of vanity."[29] Ty Burr of The Boston Globe wrote, "Tomei gives a brave and scrupulously honest performance, one that's most naked when Pam has her clothes on."[30] Variety exclaimed, "Tomei is in top, emotionally forthright form as she charts a life passage similar to Ram's."[31] For her performance she was nominated for her first BAFTA, second Golden Globe and third Academy Award for Best Supporting Actress.
In 2009, Tomei recorded the role of Mary Magdalene in Thomas Nelson's audio Bible production The Word of Promise.[32]
Tomei was No. 18 on the 2009 FHM list of "100 Sexiest Females in the world".[33] The following year she appeared in two films: a comedy-drama, Cyrus and a comedy, Grown Ups.[citation needed] Tomei hosted the 2011 Scientific and Technical Awards, which was followed by an appearance at the 83rd Academy Awards.[34] She starred alongside Matthew McConaughey and Ryan Phillippe in the mystery suspense film The Lincoln Lawyer. She also appeared with Jennifer Connelly, Pierce Brosnan and Greg Kinnear in Salvation Boulevard, which premiered at the 2011 Sundance Film Festival. Tomei's other 2011 films included Crazy, Stupid, Love., with Steve Carell, Julianne Moore, Ryan Gosling, and Emma Stone, and the George Clooney film The Ides of March, with Clooney, Ryan Gosling, and Paul Giamatti. She is in talks to star alongside Sarah Jessica Parker in the indie comedy Married and Cheating.[35] In an interview, Lady Gaga stated that she would want Tomei to portray her in a film about the singer. Tomei responded, "I was thrilled when I heard. I love her. I love her music. And she's a smart businesswoman. So I was so touched, really. I think it's incredible that she likes my work and that she'd think of me."[36]
Tomei was featured in the second episode of the third season of NBC's Who Do You Think You Are?, on February 10, 2012. In the episode, she traveled to the Tuscany region of Italy and the island of Elba (part of Tuscany) to uncover the truth about the 100-year-old murder of her great-grandfather, Francesco Leopoldo Bianchi, on her mother's side of the family.[37]
Year | Title | Role | Notes |
1984 | Flamingo Kid, TheThe Flamingo Kid | Mandy | |
1984 | Toxic Avenger, TheThe Toxic Avenger | Health Club Girl | Uncredited[38] |
1986 | Playing for Keeps | Tracy | |
1991 | Oscar | Lisa Provolone | |
1991 | Zandalee | Remy | |
1992 | My Cousin Vinny | Mona Lisa Vito | |
1992 | Equinox | Rosie Rivers | |
1992 | Chaplin | Mabel Normand | |
1993 | Untamed Heart | Caroline | |
1994 | Only You | Faith Corvatch | |
1994 | Paper, TheThe Paper | Martha Hacket | |
1995 | Perez Family, TheThe Perez Family | Dorita Evita Perez | |
1995 | Four Rooms | Margaret | |
1996 | Unhook the Stars | Monica Warren | |
1997 | Brother's Kiss, AA Brother's Kiss | Missy | |
1997 | Welcome to Sarajevo | Nina | |
1998 | Slums of Beverly Hills | Rita Abromowitz | |
2000 | Happy Accidents | Ruby Weaver | |
2000 | Watcher, TheThe Watcher | Dr. Polly Beilman | |
2000 | What Women Want | Lola | |
2000 | King of the Jungle | Det. Costello | |
2000 | Dirk and Betty | Paris | |
2001 | In the Bedroom | Natalie Strout | |
2001 | Someone Like You | Liz | |
2002 | Wild Thornberrys Movie, TheThe Wild Thornberrys Movie | Bree Blackburn | voice |
2002 | Just a Kiss | Paula | |
2002 | Guru, TheThe Guru | Lexi | |
2003 | Anger Management | Linda | |
2004 | Alfie | Julie | |
2005 | Loverboy | Sybil | |
2005 | Marilyn Hotchkiss' Ballroom Dancing and Charm School | Meredith Morrison | |
2005 | Factotum | Laura | |
2006 | Danika | Danika | |
2007 | Grace Is Gone | Woman at Pool | |
2007 | Wild Hogs | Maggie | |
2007 | Before the Devil Knows You're Dead | Gina Hanson | |
2008 | War, Inc. | Natalie Hegalhuzen | |
2008 | Wrestler, TheThe Wrestler | Cassidy/Pam | |
2010 | Cyrus | Molly | |
2010 | Grown Ups | Spectator | Cameo |
2011 | Lincoln Lawyer, TheThe Lincoln Lawyer | Margaret McPherson | |
2011 | Salvation Boulevard | Honey Foster | |
2011 | Crazy, Stupid, Love. | Kate | |
2011 | Ides of March, TheThe Ides of March | Ida Horowicz | |
2012 | Inescapable | Fatima | |
2012 | Parental Guidance | Alice | |
2014 | Love Is Strange | Kate |
Year | Title | Role | Notes |
1984 | As the World Turns | Marcy Thompson | 2 episodes |
1987 | ABC Afterschool Special | Noelle Crandall | Episode: "Supermom's Daughter" |
1987 | Leg Work | Donna Ricci | Episode: "Pilot" |
1987 | Different World, AA Different World | Maggie Lauten | 21 episodes |
1996 | Seinfeld | Herself | Episode: "The Cadillac" |
1998 | Since You've Been Gone | Tori | Uncredited |
1998 | Only Love | Elvie | |
1998 | My Own Country | Mattie Vines | Movie |
2003 | Simpsons, TheThe Simpsons | Sara Sloane (voice) | Episode: "A Star Is Born Again" |
2006 | Rescue Me | Angie Gavin | 4 episodes |
2007 | Rich Inner Life of Penelope Cloud, TheThe Rich Inner Life of Penelope Cloud | Penelope Cloud | Movie |
Year | Title | Role | Notes |
2010 | Core and Curves | Herself | Exercise video |
Stage work[edit]
Tomei has also done substantial work in the theatre.
- 1987: Beirut
- 1994: Slavs!
- 1998: Wait Until Dark (lead Broadway role)
- 2003: Salomé (lead Broadway role)
- 2008: Top Girls
Awards and nominations[edit]
- ^ "Marisa Tomei". Box Office Mojo. Retrieved 2011-02-04.
- ^ Rochlin, Margy (1997-02-02). "Vinny's Girlfriend, Climbing Back After Success". The New York Times. Retrieved 2008-10-18.
- ^ "Marisa Tomei Biography.". Tiscali.co.uk. Retrieved 2011-02-04.
- ^ Stated on Who Do You Think You Are?, February 10, 2012
- ^ a b "Maris Tomei Biography. Yahoo! Movies". Yahoo!. 1964-12-04. Retrieved 2011-02-04.
- ^ Euvino, Gabrielle. The Complete Idiot's Guide to Italian History and Culture. Alpha Books, 2002. ISBN 0-02-864234-1.
- ^ "Film professor researches how female stardom links to American views on immigration and ethnicity". University of North Texas. October 25, 2001.
- ^ Collins, Glenn. "Actress's Challenge in Change of Pace and Diction", The New York Times, August 10, 1992. Retrieved October 23, 2007.
- ^ "UP AND COMING: Marisa Tomei; She's Straight Out of Brooklyn". The New York Times. 1992-03-22. Retrieved 2010-05-29.
- ^ Canby, Vincent (March 13, 1992). "My Cousin Vinny (1992) Review". The New York Times. Retrieved 2011-06-02.
- ^ Roger Ebert Movie Answer Man : the questions that will not die, August 27, 2000
- ^ Diane Negra, Off-white Hollywood: American culture and ethnic female stardom Routledge, 2001, ISBN 0-415-21678-8, p. 160
- ^ Richard Roeper Urban Legends: The Truth Behind All Those Deliciously Entertaining Myths That Are Absolutely, Positively, 100% Not True, Career Press, 2000,ISBN 1-56414-418-6, p. 127
- ^ Truth and rumors: the reality behind TV's most famous myths. Google. December 2007. ISBN 978-0-275-99247-7. Retrieved 2010-05-29.
- ^ Roger Ebert, Movie Answer Man, June 15, 1997
- ^ "Marisa Tomei Awarded Oscar by Mistake?". snopes.com. Retrieved 2010-07-31.
- ^ "Marisa Tomei on 'The Wrestler' and that weird, pesky rumor that she didn't really win the Oscar for 'Vinny'". Los Angeles Times. 2008-12-15. Retrieved 2010-05-29.
- ^ Roger Ebert, Movie Answer Man
- ^ Young, Josh (March 6, 2002). "Return Tomei". Entertainment Weekly. Retrieved 2011-06-02.
- ^ Holden, Stephen The New York Times November 1, 1996 Unhook the Stars (1996) Retrieved February 2, 2011.
- ^ Rotten Tomatoes Slums of Beverly Hills review
- ^ Maslin, Janet (August 14, 1998). "The Slums of Beverly Hills (1998)". The New York Times. Retrieved 2011-03-13.
- ^ Levy, Emanuel (May 24, 1998). "Slums of Beverly Hills". Variety. Retrieved 2011-03-13.
- ^ Richard Schickel, The Appeal of Her Zeal, Time, May 18, 2002
- ^ McCarthy, Todd (January 22, 2001). "In the Bedroom". Variety. Retrieved 2011-06-02.
- ^ Holden, Stephen (November 23, 2001). "In the Bedroom (2001)". The New York Times. Retrieved 2001-11-23.
- ^ Mohr, Jay (2004-06-09). Gasping For Airtime: Two Years In the Trenches of Saturday Night Live. Hyperion. ISBN 1-4013-0006-5.
- ^ Freydkin, Donna (2008-12-21). "Marisa Tomei: A no-holds-barred acting job in 'Wrestler'". USA Today. Retrieved 2011-03-17.
- ^ Farber, Stephen (2008-09-05). "Review". The Hollywood Reporter. Retrieved 2011-03-17.
- ^ Burr, Ty The Boston Globe December 25, 2008 The Wrestler film review Retrieved February 1, 2011.
- ^ McCarthy, Todd September 5, 2008 Variety The Wrestler Retrieved February 1, 2010.
- ^ "BELIEFS : Stars lined up for elaborate audio Bible : Michael York, Jason Alexander and many others gave voice to a 79-CD reading of Old and New Testaments".
- ^ "FMH 100 Sexiest 2009." FHM magazine. April 2009.
- ^ Academy of Motion Picture Arts & Sciences Press Release February 12, 2011 Marisa Tomei to Host Academy's Sci-Tech Awards Retrieved February 5, 2011.
- ^ "Marisa Tomei and Sarah Jessica Parker Are 'Married and Cheating'". First Showing. 2011-03-13. Retrieved 2011-03-17.
- ^ "There's no questioning Tomei's acting range". The Charlotte Observer. 2011-03-17. Retrieved 2011-03-17.
- ^ "First look at Marisa Tomei on NBC's Who Do You Think You Are(VIDEO)". Unreality TV. February 6, 2012. Retrieved February 6, 2012.
- ^ "(official studio site)". ToxicAvenger. Retrieved 2011-02-04.
External links[edit]
Wikimedia Commons has media related to Marisa Tomei. |
- Marisa Tomei at the Internet Movie Database
- Marisa Tomei at the Internet Broadway Database
- Marisa Tomei at the Internet Off-Broadway Database
- 1964 births
- 20th-century American actresses
- 21st-century American actresses
- Actresses from New York City
- American film actresses
- American people of Italian descent
- American soap opera actresses
- American stage actresses
- American television actresses
- Best Supporting Actress Academy Award winners
- Boston University alumni
- Living people
- People from Brooklyn


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Risky but right move for Bruins to trade Tyler Seguin
The Bruins' trade of Tyler Seguin instantly garnered an emotional and pretty divided response among fans when it was announced Thursday afternoon in the midst of countless cookouts across New England.
Initially, the narrative boiled down to two camps:
- This is ridiculous! He's 21 years old! The B's gave up on him way too early.
- The kid's immature and he's an underachiever! Get something while you can.
Really, there's probably a bit of truth in both.
Seguin put together an average (by expectation, that is) lockout-shortened season in which he scored 16 goals and totaled 32 points to rank tied for third on the Bruins in scoring. He added a plus-23 rating. What the numbers didn't show were his bouts with inconsistency, limited hockey sense, and generally soft-natured style. Call it an unwillingness to "play like a Bruin," if you'd like.
The postseason was an entirely different story; one that didn't involve any smoke or mirrors. In fact, it read more like a missing person's report.
Seguin scored a mere one goal – coincidentally in a rare loss against the Rangers – on 70 shots and he accounted for eight total points, good for ninth on the team, while eventually being demoted to the third line. Not good for a guy on the brink of starting a 6-year, $34.5 million extension. Not good for a former second overall draft pick in his third season. Not good for a guy who was given every opportunity to succeed but simply couldn't find his groove. Let's just ignore for now the minus-two rating he ended the playoffs with as the rest of his squad was a plus-77.
Coupled with that lack of production were the organization's ever-growing concerns that Seguin wasn't enough of a professional, as general manager Peter Chiarelli discussed quite publicly last weekend at the NHL Draft. In short, the GM could live with his budding star's floating style of play, but he'd had enough of the kid's lack of focus and commitment.
Despite trade rumors involving the Calgary Flames, I took Chiarelli's comments to stand for more of a grand warning than a real threat of movement. At 21, Seguin's upside seemed too great. I was wrong.
Now, as so often happens when a controversial figure leaves town, the stories of Seguin's off-ice indiscretions, some which had been so thoughtfully overlooked previously, are hitting the Internet like a tabloid. The latest, and it's a juicy one, comes from Comcast SportsNet New England's Joe Haggerty, who describes the youngster's ill-advised partying while on the road during the playoffs. That, in all likelihood, is just the beginning.
But, make no mistake, if Seguin had shined over the last few months – heck, shown up at all – we're not talking right now about his trip to Dallas.
The B's have shown a willingness over the last few years to deal with a little immaturity, however frustrating it may have been. After all, he's a young, good-looking professional athlete in a major city, already with a Stanley Cup championship, and millions of dollars on the way. To a certain extent, kids will be kids. The Blackhawks learned that with Seguin's overseas roommate, Patrick Kane, and now he's a Conn Smythe winner. Without the production, that's when you're labeled an expendable and overpaid headache.
So here we are. Seguin, teammate Rich Peverley (and his hefty $3.25 million cap hit each of the next two seasons), and minor leaguer Ryan Button are bound for the Stars. In return, the Bruins receive Loui Eriksson and prospects Joe Morrow, Matt Fraser and Reilly Smith.
Today, and seemingly for the next few seasons, the Bruins are almost undisputedly the winner of this trade. With the salary cap dropping, the B's cleared $4.75 million in space for next year – helpful when considering that Tuukka Rask is in line for a big payday and the team is in need of wingers without Seguin, Peverley, Nathan Horton, and assumedly Jaromir Jagr – and they get a nearly 28-year-old durable and consistently proven scorer in Eriksson.
The veteran of seven seasons has scored 150 goals and tallied 207 assists in 501 career regular season games. In his last four full NHL seasons, the future right wing has missed only three games and averaged 29.5 goals and 69.5 points a year. Seguin scored 29 goals and led the Bruins in scoring with 67 points as a 20-year-old All-Star in 2011-12, far and away his best professional effort. One glaring difference, though, is that Eriksson hasn't enjoyed a trip to the postseason since his Stars reached the Western Conference Finals in 2008. The native of Sweden was your classic case of a good player on a bad team for the last several years, but he joins a perennial contender in Boston with a system more suited for his style than that of the guy he's replacing.
Eriksson, on the books for three more seasons at $4.25 million per, is a fast, top-line talent who's described as a solid two-way player with a good shot, positional flexibility on the wing, and he's deadly on the power play (accounting for 36 of his 43 career special teams goals). It also doesn't hurt that he played with Senators free agent captain Daniel Alfredsson – coveted by Chiarelli since his days in Ottawa – at the World Championships and in the Olympics.
Another intriguing piece to the deal is Morrow, a first-round selection of the Penguins in 2011, and a player who Chiarelli believes will eventually be a top-four NHL defenseman. Fraser and Smith bring some top-level experience and depth up front.
Ultimately, though, unless Morrow turns out to be something great in a Black and Gold sweater, this will be remembered as the Seguin for Eriksson swap.
Seguin, who displayed flashes of brilliance with 56 goals and 65 assists in 203 regular season games before being regularly stunted in the playoffs (three goals in his last 40 games after three scores in his first two contests), now has a chance at, as Horton's agent might say, a "new beginning." It's a return to his natural center position, which he never got a fair shake at playing in Boston because he wasn't going to leap-frog David Krejci or Patrice Bergeron.
Moreover, it's an opportunity to positively explode offensively in a system that's less defensively-stimulated; to put up numbers he never would have accumulated under Claude Julien's watch. [As an aside, I only hope Seguin's camp doesn't begin to respond to these party-themed allegations with attacks that Julien's system held him back or hampered his development. The less drama, the better.] That performance may decide the winner of this trade in the long-run, though a Cup title or two for the Bruins while Seguin's in the Lone Star State could render even a Hall of Fame career inferior in the argument.
In the here and now, and I suspect the future as well, this is the right move for Chiarelli. He made exactly the correct draft pick on that June night in Los Angeles back in 2010; it just didn't pan out. Whether influenced by the current salary cap situation or not, give him credit for cutting ties while Seguin's value is still very high and shedding Peverley's crummy contract in the process. What either player would have done as Bruins going forward no longer matters, only how the new guys fit in.
Still, I can't help what wonder what Seguin – the man once projected to be Steven Stamkos – is thinking about all this. Is he excited for this fresh start in Dallas, or wishing he'd done a few things differently in Boston?
Follow me on Twitter at @AdamMKaufman
The author is solely responsible for the content.
About this blog
Adam Kaufman is a writer and broadcaster who can also be heard regularly on 98.5 The Sports Hub, WBZ NewsRadio 1030, the national CBS Sports Radio Network, and broadcasting Boston College hockey games. The Massachusetts native is a Syracuse grad and a pop culture fanatic who offers a unique and entertaining look at your favorite Boston sports teams. Please don't hold his love for Jean-Claude Van Damme movies against him.
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The strange moves just keep on coming. In a trade broken by Tennessean beat writer Joshua Cooper, the Nashville Predators have traded Alexander Sulzer to the Florida Panthers for a conditional seventh round draft pick. According to Cooper, the pick is conditional on Sulzer re-signing with the Panthers.
We'll have more on this as we find out, but for now, Nashville only has 17 healthy skaters.
Steve Sullivan has also been placed on injured reserve with a 'recurring groin injury.'
Press release after the jump.
Nashville, Tenn. (February 25, 2011) - Nashville Predators President of Hockey Operations/General Manager David Poile announced today that the club has acquired a conditional seventh-round pick in the 2012 Entry Draft in exchange for defenseman Alexander Sulzer. Nashville will receive the seventh-round pick if Sulzer appears on the Florida's Reserve List during the 2011-12 season.
Sulzer is one of a franchise-record 18 Predators draftees to appear for the club this season, posting four points (1g-3a) in 31 games. He was selected 92nd overall (third round) in the 2003 Entry Draft.


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Bioequivalency Study of Letrozole 2.5 mg Tablets Under Fasted Conditions
This study has been completed.
Roxane Laboratories
Information provided by (Responsible Party):
Roxane Laboratories
ClinicalTrials.gov Identifier:
First received: June 3, 2011
Last updated: January 17, 2014
Last verified: January 2014
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The objective of this study was to prove the bioequivalence of Letrozole Tablet under fasted conditions.
Condition | Intervention | Phase |
Breast Cancer |
Drug: Letrozole |
Phase 1 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Endpoint Classification: Bio-equivalence Study Intervention Model: Crossover Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | A Single Dose, 2-Period, 2-Treatment 2-Way Crossover Bioequivalency Study of Letrozole Tablets Under Fasted Conditions |
Resource links provided by NLM:
Genetics Home Reference related topics:
breast cancer
MedlinePlus related topics:
Drug Information available for:
U.S. FDA Resources
Further study details as provided by Roxane Laboratories:
Primary Outcome Measures:
- bioequivalence determined by statistical comparison Cmax [ Time Frame: 31 days ] [ Designated as safety issue: No ]
Enrollment: | 28 |
Study Start Date: | March 2008 |
Study Completion Date: | April 2008 |
Primary Completion Date: | April 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Active Comparator: Letrozole
2.5 mg tablet
Drug: Letrozole
2.5 mg Tablet
Other Name: Femara
Active Comparator: Femara
2.5 mg tablet
Drug: Letrozole
2.5 mg tablet
Other Name: Femara
Ages Eligible for Study: | 18 Years to 45 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- No clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening
Exclusion Criteria:
- Positive test for HIV, Hepatitis B, or Hepatitis C.
- Treatment with known enzyme altering drugs.
- History of allergic or adverse response to letrozole or any comparable or similar product.
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01367652
United States, North Dakota | |
PRACS Institute, Ltd. | |
Fargo, North Dakota, United States, 58104 |
Sponsors and Collaborators
Roxane Laboratories
Principal Investigator: | Alan Copa, PharmD | PRACS Institute, Ltd. |
More Information
No publications provided
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 06, 2014
No publications provided
Responsible Party: | Roxane Laboratories |
ClinicalTrials.gov Identifier: | NCT01367652 History of Changes |
Other Study ID Numbers: | LETR-T25-PVFS-1 |
Study First Received: | June 3, 2011 |
Last Updated: | January 17, 2014 |
Health Authority: | United States: Institutional Review Board |
Additional relevant MeSH terms:
Breast Neoplasms Neoplasms by Site Neoplasms Breast Diseases Skin Diseases Letrozole |
Antineoplastic Agents Therapeutic Uses Pharmacologic Actions Aromatase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action |
ClinicalTrials.gov processed this record on March 06, 2014


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Nov 30, 2004 | 05:51 AM |
Aluminum giant Alcan Inc. will cut about 520 jobs as part of a major restructuring across nine of its European operations.The Montreal-based company said it plans to close its rolled products plant in Flemalle, Belgium, and two packaging operations in Cruseilles, France, and Garbagnate, Italy, as part of the restructuring.....
Aluminum giant Alcan Inc. will cut about 520 jobs as part of a major restructuring across nine of its European operations.
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Will more metals companies discontinue health care coverage for their employees in light of the Affordable Care Act?
June 20-21, 2013 New York
Billet is the strongest part of the aluminum business right now. ... I can't pinpoint exactly why (but) ... some customers are ordering double what they did last year.
--Aluminum trader


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Executive Assistant Assassins
Series: Aspen Comics Executive Assistant Assassins
volume: 11
publisher: Aspen Comics
product type: digital comic/eComic (Ongoing Series)
Explore the creation of a master assassin and the tragic past of Executive Assistant Lotus in "Bloodline", the origin of one of the EA Universe's most popular-and deadly-heroines. As a child raised in India, Rani (Lotus) was continually teased amongst her peers for her vulnerability and proclivity towards technology and science. However, following a horrific turn of events that shatters her existence at its core, Rani must choose to grow up fast, and to rely on her survival instincts and technical expertise in order to survive-or die!


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Length: | 29.5 in. |
Width: | 78 in. |
Height: | 56 in. |
Weight: | 908 lbs. |
Horsepower: | 15 |
Lubrication: | Oil-Lube |
Maximum Pressure: | 175 PSI |
Motor: | NEMA |
Motor Phase: | Three |
Power Type: | Electric |
Pump Style: | Steel |
SCFM At 40 PSI: | 54.4 |
SCFM At 90 PSI: | 51 |
Style: | Horizontal |
Tank Capacity: | 120 gal. |
Voltage: | 208 - 230/460V |
Do you have questions about this product?
get answers from real customers and in-house experts with AnswerBox.
How much oil/how many quarts of oil does this 3 stage compressor take?0 answers
NEW Air Compressors: From the date of purchase by the original purchaser as follows: Standard Duty - One Year; Serious Duty - Two Years; Extreme Duty - Three Years; Maxus Model Series - Five Years.
RECONDITIONED Air Compressors: From the date of purchase by the original purchaser as follows: One Year Limited Warranty.
WHO GIVES THIS WARRANTY (WARRANTOR):Campbell Hausfeld / Scott Fetzer Company, 100 Production Drive, Harrison, Ohio, 45030, Telephone: (800) 543-6400
WHO RECEIVES THIS WARRANTY (PURCHASER): The original purchaser (other than for purposes of resale) of the Campbell Hausfeld compressor.
WHAT IS COVERED BY THIS WARRANTY: Substantial defects due to material and workmanship with the exceptions noted below on any Campbell Hausfeld air compressor.
Additional items not covered under this warranty:
All Compressors:
Lubricated Compressors
Belt Drive / Direct Drive / Gas Driven Compressors
RESPONSIBILITIES OF WARRANTOR UNDER THIS WARRANTY: Repair or replace, at Warrantor's option, compressor or component which is defective, has malfunctioned and/or failed to conform within duration of the warranty period.
WHEN WARRANTOR WILL PERFORM REPAIR OR REPLACEMENT UNDER THIS WARRANTY: Repair or replacement will be scheduled and serviced according to the normal work flow at the servicing location, and depending on the availability of replacement parts. This Limited Warranty applies in the U.S., Canada and Mexico only and gives you specific legal rights. You may also have other rights which vary from State to State or country to country.


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4.6 out of 5
7 Reviews
Very comfortable
August 04, 2011
I was skeptical on how comfortable this boot would be. I wanted something that I could wear in the water and on land. I wear a size 10.5 shoe size and purchased the 11. I am glade I went with the larger size. The boot holds firm and tight no matter where I go. It has a really soft sole that provides comfort even on long jouneys. I would not recommed on hot days unless your feet are going to be in the water because they will get really hot. I wear them when white water rafting with minimal hicking and they work great!
Pros: comfortable, good traction, Cons: feet get wormGreat sole. Nice finish
August 09, 2007
These wet shoes are headed for the BWCAW. I have a pair of NRS Attach shoes that fit great in a low volume sea kayak but I needed more of a stout sole for use on canoe portage trails in the BWCAW. The lug sole is perfect for canoeing and portaging. If you pair them with the NRS 2 mm wetsocks, order up one size to accomodate the sock. They would rate five stars except they are a tad heavy. Order them with confidence.
June 06, 2012
The boot fits true to size, however the material has changed over the years and is much softer than older versions of this boot. I wear an 11 in regular footwear and I size up a size to fit over my rescue suit in this boot. Because of the softer material I am going to get my regular size.
Excellent for Texas flats wading
August 25, 2008
This is the best wading shoe I have found for wading Texas flats. The stout sole and adjustable arch support handle the soft muck and plentiful razor sharp oyster shells with ease and stability. My family owns four pair of these.
A great purchase for my Trip to BWCA.
September 17, 2008
I bought these boots for my trip to BWCA where I knew that I would be getting wet, hiking (portaging), and canoeing. They worked great! They kept my feet warm in the cold water and were very comfortable. However, I was told to buy the boots in half size larger for space. That extra space caused my feet to move to much. I didn't wear socks with the boots ( your not supposed to) so I would recommend getting your normal size if you are going to be out of the water with them. Over all this was just what I wanted for the trip and I plan to use them again the next time I go!
great wetshoe
March 10, 2011
I recently had the opportunity to try out the ATB wetshoes. I had quite high expectations of a NRS product and I was not disapointed. I found the fit at size 11 was spot on. The hook and loop instep strap is a very nice feature as it allows for a very secure feeling if there's any mud or muck on the river bank. The tread on the sole provides good traction with out being to heavy.
Great Shoe, Worked Exactly as Planned
June 01, 2010
I bought these for wading in gravel and mud creeks in SE Kansas. On a four day trip, never had anything get in the shoe, and never felt one rock through the sole. A little heavy out of the water, but other than that, an absolutely great product. Highly recommend.
Available sizes, while supplies last, include size 6, size 7, size 8, size 9, size 10, size 11, size 12, size 13 and size 14: 6, 7, 8, 9, 10, 11, 12, 13, 14.


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Women's Swimwear
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Garnet Hill
Garnet Hill Ruched Swim Skirt
Thin material and poor quality. . .
I normally LOVE GH swim suits but this skirted bottom is terrible. I purchased the "midnight (black) stripe" color. It did not look like the photo (the stripe is beige and looks dingy). I have never had a problem with fit before but this item is very short and very tight in my normal size. I do not like the low cut on this bottom either. The material is very thin and I feel that the quality is very poor. Try a GH "signature" swim skirt instead!
February 19, 2014
Cute skirt
I bought two of these. Went down a size on the second order. I am 69 years old and this does not look "old lady".
February 5, 2014
Great skirt
Perfect fit! The photo makes it look a bit longer than it fits on me. Gives nice coverage, easy to wear, looks very cute without looking old-fashioned. I love it! I wear it along with the ruched top for a very light but comfortable pool and beach set.
January 27, 2014
flattering and good coverage.
I should have ordered a size down but normally swimsuits run smallish . If you unsure you might want to chose smaller size.
October 7, 2013
Great for the beach!
This swim skirt is not too "skirty" and looks cute with my solid black swim top. For the sale price, it's a keeper!
September 19, 2013
awesome little skirt!
this skirt is short! It has panties in it. I wear it for beach but over a bikini. I also wear it to yoga over my hot yoga gear (not in the hot class) as a cover up going in and out. If you are someone who likes to get a tan in your front yard without shocking your neighbors with your bikini, this is the perfect little skirt for you. Also good if you are at a resort or place with swimming pool to head down to the pool.
September 2, 2013
(8 Questions : 19 Answers)
Product Q&A
Ask your questions. Share your answers.
1 year, 9 months ago
yes, attached - very comfortable - bottom1 year, 6 months ago
Yes it has a built in bottom,. very comfortable!Age: 55-64
Gender: Female
1 year, 6 months ago
Yes, there is a brief attached to the swim skirt.Age: 45-54
Gender: Female
1 year, 6 months ago
Top 1000 Contributor
Yes there is a built in bottom.1 year, 8 months ago
There is a built in bottom attached to the skirt.Age: 45-54
Gender: Female
1 year, 9 months ago
Yes. It has a fully lined bikini bottom attached at waistband seam.1 year, 9 months ago
Age: 45-54
Gender: Female
2 years, 8 months ago
it is a regular length and just covers your rear end without too much excess fabric, works for swimming not just lounging.Age: 45-54
Gender: Female
1 year, 9 months ago
We measured our size 12 sample from below the 1-3/4" band to the bottom of the skirt. It measures 10" in the front and 11" in the back. These measurements will vary slightly for smaller or larger sizes.2 years, 8 months ago
2 answers
How does the fit of this skirt compare to the fit of GH pants? (specifically the slim cut cords)
Age: 25-34
Gender: Female
2 years ago
Top 1000 Contributor
It clings to the top of the thighs a bit. I have the boyfriend shorts in a 2 which fit perfectly and true to size. I ordered this in a 4 (for ample coverage in a swimsuit), but it still clings...I think it is supposed to fit this way. I still like it though. I would order up if in doubt.1 year, 9 months ago
We are sorry but we really can't compare a swim skirt to a pair of pants however we do recommend ordering according to your pant size.2 years ago
Age: 45-54
Gender: Female
1 year, 10 months ago
I would say it is gunmetal grayAge: 55-64
Gender: Female
1 year, 10 months ago
The background color on the pink blooms is graphite.1 year, 10 months ago
Age: 45-54
Gender: Female
1 year, 9 months ago
yes it does.Age: 45-54
Gender: Female
1 year, 7 months ago
The dark slate and the background color of the pink blooms do not match.1 year, 9 months ago


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CALRAD Electronics Dual IR Flashing Emitter - 10-Pack
Item#: YYI1-KV9096 | Model#: 92-152-2-10DUAL IR FLASHING EMITTER KIT Product Details
- 3.5mm plug
- 6' cord
- 10-pack
Manufactured by: CALRAD
Warranty provided by: CALRAD
Mfg Part No: 92-152-2-10
UPC No: 601520952109
Box Size: ( Length:0, Width:0, Depth:0)
Shipping Weight: 0.8000 pound(s)
Click here for full warranty and support information - Limited Warranty: A full text version of the limited warranty
may be obtained by mailing a self addressed, stamped envelope to the
address below and requesting the warranty for item number: YYI1-KV9096
Warranty Information
7795 W. Flagler St. Suite 35
Miami, FL. 33144 - CALRAD logos are registered trademarks of CALRAD. All others trademarks and copyrights mentioned herein are the property of their respective owners.


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Unlike David Benson-Pope I have been selected for hanging and final judging....
....at least my entry into the 2006 National Bienniel Portrait Competition has.
Who is managing Labour's social media campaign?
11 minutes ago
This blog intends to debunk the myths surrounding the welfare state. The government is not caring and compassionate. It cannot replace families and community. The welfare state is unsustainable economically, socially and morally.


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3/17/2014 11:39:33 AM. For Customer Service, please call
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The Story
Graceful curves reshape a timeless setting into a classic for today. Smooth contoured handles subtly arch to contemporary forms crafted in gleaming stainless steel.
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497 Franklin St Melrose, MA 02176-1742
For train information at Melrose Highlands Station tune to 1630 AM
This MBTA station is accessible (Accessibility Key)
Parking Spaces: 77
Average Weekday Availability:
Parking Rate: $2.00
Accessible Spaces: 2
Bike Spaces: N/A
Managed By: City of Melrose
City of Melrose is responsible for parking lot snow removal, maintenance and fee collection. Please contact MBCR [click here] regarding station and platform snow removal, cleanliness and maintenance issues.
Commuter Rail Lines
Fare Information
Travel anywhere on the MBTA system for the same price.See all Fares & Passes information.
Transit Mode | Passes / Tickets |
Rail |
$2.00 - $11.00 Zones 1A - 10 $70 - $345 Monthly Pass, unlimited travel to and from your zone plus travel on all bus, subway and Inner Harbor Ferry. 50% Seniors and Persons with Disabilities |
Bus |
$1.50 CharlieCard $2.00 CharlieTicket / Cash-on-board $48 Monthly Bus Pass $70 LinkPass - unlimited travel on Local Bus and Subway. |


text:
Please enter your travel dates.
Standard Room, 2 Queen Beds
Standard Room, 1 King Bed
Standard Room, 1 King Bed (Spa)
Suite, 1 King Bed with Sofabed
Suburban hotel one mile from Mall of America
With a stay at Courtyard by Marriott Minneapolis Bloomington in Bloomington (Bloomington - Mall of America), you'll be minutes from Water Park of America and close to Mall of America.
This hotel is within close proximity of Nickelodeon Universe and Sea Life Minnesota Aquarium.
Make yourself at home in one of the 193 air-conditioned guestrooms. Complimentary wired and wireless Internet access is available. Conveniences include desks and complimentary weekday newspapers, as well as multi-line phones with voice mail.
Be sure to enjoy recreational amenities, including an indoor pool, a spa tub, and a fitness center. Additional amenities include complimentary wireless Internet access, concierge services, and an arcade/game room.
Enjoy a meal at a restaurant, or stay in and take advantage of the hotel's room service (during limited hours). Quench your thirst with your favorite drink at a bar/lounge.
Featured amenities include complimentary high-speed (wired) Internet access, audiovisual equipment, and express check-out. Planning an event in Bloomington? This hotel has 2800 square feet (260 square meters) of space consisting of conference/meeting rooms and banquet facilities. A roundtrip airport shuttle is provided at no charge.
Hotel Amenities
- General
Courtyard by Marriott Minneapolis Bloomington provides free shuttle service to the airport and the Mall of America. The front desk handles requests for faxes and photocopies, and guests can use a printer in the lobby. Six meeting rooms can accommodate groups of up to 70, and catering is available. Wired and wireless Internet access is complimentary.
An indoor pool, fitness center, and 24-hour convenience mart are also on site.
The heated underground parking (surcharge) is a boon during Minnesota winters.
- 24-hour front desk
- Air-conditioned public areas
- Airport transportation (complimentary)
- Arcade/game room
- ATM/banking
- Audiovisual equipment
- Banquet facilities
- Business services
- Complimentary newspapers in lobby
- Multiple large conference rooms
- Dry cleaning/laundry service
- Event catering
- Express check-out
- Fitness facilities
- Laundry facilities
- Multilingual staff
- Parking garage
- Patio
- Room service (limited hours)
- Safe-deposit box at front desk
- Security guard
- Swimming pool - indoor
- Use of nearby fitness center (complimentary)
- Total number of rooms - 193
- Number of floors - 7
- Bar/lounge
- Concierge services
- Free Wi-Fi
- Free wired high-speed Internet
- Free guest parking during stay
- Restaurant
- Meeting facilities size (meters) - 260
- Number of meeting/conference rooms - 6
- Year Built 1998
- Meeting facilities size (feet) - 2800
- Smoke-free property
- Number of buildings/towers - 1
- Spa tub
- Breakfast available (surcharge)
- Free parking
- Internet
Available in all rooms: Free Wi-Fi, Free wired high-speed Internet
Available in some public areas: Free Wi-Fi, Free wired high-speed Internet
- Parking
Free parking, Free guest parking during stay, Parking garage
- Room Amenities
- Air conditioning
- Climate control
- Clock radio
- Coffee/tea maker
- Complimentary weekday newspaper
- Cribs/infant beds available
- Desk
- Extra towels/bedding
- Hair dryer
- Daily housekeeping
- Iron/ironing board
- Multi-line phone
- Private bathroom
- Rollaway/extra beds available
- Voice mail
- Wake-up calls
- Window opens
- Connecting / adjoining rooms available
- Free Wi-Fi
- Free wired high-speed Internet
- Dining
Jake's Restaurant and Bar - This subdued, white-tablecloth restaurant and bar just off the lobby serves breakfast, lunch, and dinner, with a comfort-food menu that features American and regional specialties such as Minnesota walleye, Bourbon Salmon, and meatloaf.
- Recreation
The visitor center for the 14,000-acre Minnesota Valley National Wildlife Refuge—one of only four urban wildlife refuges in the U.S.—is 2 miles east of the hotel. Prime activities there include walking the trails, bird-watching, and nature photography. Also nearby is Fort Snelling State Park, with facilities for hiking, biking, skiing, and canoeing. The Mall of America, of course, provides miles of corridors for all-season walking.
The recreational activities listed below are available either on site or near the hotel; fees may apply.
- Golfing nearby
- Hiking/biking trails nearby
- Rowing or canoeing nearby
- Skiing - cross-country nearby
- Swimming nearby
- Accessibility
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessible bathroom
- Accessible path of travel
- Braille or raised signage
- Accessible parking
- In-room accessibility
- Roll-in shower
Policies & Fees
- Check-in
Check-in time starts at 3 PM
- Check-out
Check-out time is noon
- Payment types
Accepted at this hotel: Diners Club, Discover, MasterCard, Visa, American Express
- Pets
Pets not allowed
- General
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Fees
- The following fees and deposits are charged by the property at time of service, check-in, or check-out.
- Breakfast fee: USD 10.95 per person (approximately)
- Rollaway bed fee: USD 10 per night
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
- Additional Details
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.


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I completely agree. I know our expectations may have been a little high. but this is the best roster weve ever had. period. they should be doing better than this. and its the coaches fault.
ive been watching the NBA for a long time. and it may just be the fact that im scrutinizing him more because hes my coach... but ive never seen worse coaching in my life. its embarrassing.


text:
Plumeri warmly reflects on decade
| Mar 21, 2009
Ten years ago to the day, and Joe Plumeri remembers as if it were yesterday. Sunny and brisk afternoon. Shiny new ballpark before him. Beloved alma mater around him. Father alongside him in spirit.
A wonderful day that fell a couple of steps short of...


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Our turtles love this time of season b/c they get lots & lots of veggies. Most often there will be several turtles fighting over 1 tomato or cumcumber. Besides cucumbers & tomatos, they also love strawberries & squash.
Garden harvest time for the turtles
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07. November 2013
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BMP4 Signaling Acts via Dual-Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells
BMP4 Signaling Acts via Dual-Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells
Cell Stem Cell, Volume 10, Issue 2,
Pages 171-182,
Publication Date 3 February 2012
Copyright © 2012 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.stem.2011.12.016
Zhongwei Li
Teng Fei
Jianping Zhang
Gaoyang Zhu
Lu Wang
Danyu Lu
Xiaochun Chi
Yan Teng
Ning Hou
Xiao Yang
Hongquan Zhang
Jing-Dong J. Han
Ye-Guang Chen
The State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
Laboratory of Stem Cells, Development and Reproductive Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China
State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing 100071, China
Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Corresponding author
These authors contributed equally to this work
► BMP4 upregulates dual-specificity phosphatase 9 (DUSP9) in mouse embryonic stem cells ► DUSP9 upregulation requires Smad1/5 and Smad4 ► DUSP9 lowers ERK activity to maintain self renewal in the presence of LIF and BMP4 ► Without LIF, DUSP9 mediates BMP inhibition on neural commitment
Extrinsic BMP and LIF signaling collaboratively maintain mouse embryonic stem cell (ESC) pluripotency, whereas appropriate ERK activity is essential for ESC fate commitment. However, how the extrinsic signals restrain appropriate ERK activity remains elusive. Here, we show that, whereas LIF sustains relatively high ERK activity, BMP4 can steadily attenuate ERK activity by upregulating ERK-specific dual-specificity phosphatase 9 (DUSP9). This upregulation requires Smad1/5 and Smad4 and specifically occurs to DUSP9, but not other DUSPs, and only in ESCs. Through DUSP9-mediated inhibition of ERK activity, BMP signaling reinforces the self-renewal status of mouse ESCs together with LIF. Upon LIF withdrawal, ESCs spontaneously undergo neural differentiation, during which process DUSP9 can partially mediate BMP inhibition on neural commitment. Collectively, our findings identify DUSP9 as a critical mediator of BMP signaling to control appropriate ERK activity critical for ESC fate determination.


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Royal High School (Simi Valley, CA) Music Department, under the Direction of Band Director, Lisa Pate, will be hosting its Annual Food Truck Event - "Royal's Music Madness" on May 19, 2013 in the Royal High School West Parking Lot.
The Royal Band is proud to invite you to this fun community event. Come and enjoy sweet, savory, BBQ and delicious food. While enjoying your meal, listen to talented students from Royal High School (Jazz Ensemble, Director's Band, Party People and Jazz Combo), Simi High School (Jazz Ensemble), Santa Susanna (Jazz Ensemble and Jazz Combo) and Moorpark College (Jazz Bands A & B). We will have 10 GOURMET FOOD TRUCKS for your food delights! Come and join in the fun.
Admission is $5.00 for presale or $7.00 at the gate; children under 10 are free. Food purchases are not included in the admission price. To view the list of the Gourmet Good Trucks and to purchase admission tickets, go to: www.Royalbands.com/foodtruck.html
Many times, the music program is forgotten at schools. It is very important that parents realize the importance of music and the possibilities it can provide to enrich students lives. Mrs. Pate asked that we remind individuals that with today's budget situation, it is very difficult to purchase musical instruments, sheet music and music supplies. Royal Band Booster's are a 501 c (3) organization and will gladly accept your donation (cash or musical instruments) to help strengthen our music program.
If you have any questions about Royal High School Instrumental Music Program, please contact Lisa Pate at (805) 306-4875 or firstname.lastname@example.com If you have questions about the Food Truck Event, contact Allan Mann (805) 377-0070 or email@example.com or Antoinette Mann (805) 377-1651 or email@example.com


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Brian Joseph Arnold allegedly fled in his vehicle from a pursuing Sheriff's deputy before crashing through two fences and running away, leaving a trail of clothing behind him.
Deputies said an attempt was made to stop Arnold as he drove in the 7800 block of Old Olympic Highway around 9 p.m. Oct. 7. He continued driving, turning onto McComb Road and reaching speeds of about 60 mph, deputies said.
He then drove through two fences, stopped his car and ran away on foot, deputies said.
While attempting to locate Arnold, deputies found his shoes, a hat and blue jeans. Drug paraphernalia were found in the jeans, deputies said.
Arnold eventually was arrested and booked in the Clallam County jail at 11:42 p.m. Oct. 27.
He was charged with felony eluding a pursuing police vehicle, misdemeanor hit-and-run and misdemeanor use of drug paraphernalia. Arraignment is set for Nov. 4 and he remains in jail in lieu of $25,000 bond.


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Membership LuncheonRSE_HOSTED_BY Marjorie Sher RSE_START_EVENT RSE_MARCH 12, 2013 5:00PM RSE_END_EVENT RSE_MARCH 12, 2013 6:15PM RSE_AT_LOCATION Milan Banquet Hall Membership Luncheon Series Lunch 12:00 noon Circuit Court of Cook County, Chief Judge Timothy Evans Access to Justice Awards Hon. Timothy J. Evans, Chief Judge of the Cook County Circuit Court will make remarks and assist with the presentations. The three awards are Access to Justice Award recognizing a member (attorney or associate) who has provided or supported legal services to low-income clients; Gideon's Award to an attorney who is employed or retained by a public or non-profit agency to provide criminal legal services to low-income clients; Prosecutor Award to a prosecutor who has distinguished himself or herself in public service and whose commitment to justice and serving the communities where he or she lives or works. |
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Last edited by haribobo; 10-27-2012 at 11:11 PM.
I don't see anything in the COP that says the fastest skaters wins. As far as being held up a nationals, many believed she was held down, and should have placed over Agnes and Czisny (who also isn't the fastest skater around). She also won over Murakami and the mistake prone Agnes to podium at 4cc over some decent competition.
Wrong thread.
She wasn't sluggish, she matched the flow of her music. I also thought her arm movements were very nice. Sometimes Gracie seems to fling her arms and it can be distracting.
"I have no right, by anything I do or say, to demean a human being in his own eyes. What matters is not what I think of him; it is what he thinks of himself. To undermine a man's self-respect is a sin." - Antoine de Saint-Exupery
Prosperity makes friends, adversity tries them. Publilius Syrus
Mods feel free to delete. I was in a cruddy mood posting this.... I still believe what I said but its not really necessary to have a whole thread about it I suppose. Don't want to start a war.


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The Hallucinators Among Us
Oliver Sacks is the scientist-as-artist, a rare species nowadays but one that flourished in the mid-nineteenth century and that almost single-handedly he has kept alive. His sensibility is Victorian in the best meaning of the word: reformist, literary, historical—empirical of course but speculative as well, in the tradition of the grand theorists of that less specialized time. As a neurologist, Sacks is a clinician above all, an unusually close listener to his patients' symptoms and stories. He prefers to look through a wide-angle lens rather than a microscope. His impulse is to amplify his observations, to look beyond the minute workings of the brain to the varieties of human experience itself, something he has done much to map out in the medical case histories that comprise the core of his finest writing.
This isn't to suggest that he doesn't value the groundbreaking research of neuroscience's current pioneers, who are in the process of adding, in steady increments, to our understanding of memory and perception, but rather that his particular mission, as I suspect he sees it, is to apply their findings philosophically, to the soul.
"Soul" may seem a strange choice of word, but reading Sacks, one senses that science for him possesses a measure of divinity. Uncle Tungsten, his memoir of his childhood until the age of fifteen, is a detailed account of falling in love with science and its "dark, hidden world of mysterious laws and phenomena." As a young boy he was fascinated by the so-called "divine proportion," the classical numerical formula illustrated by the Italian mathematician Leonardo Fibonacci in the early thirteenth century, that corresponds to recurring spiral patterns in nature—for example, the face of a pine cone or sunflower, or the patterns on a ram's horn.
Sacks's sustaining passion growing up was chemistry, but at the age of fifteen, as he tells it in Uncle Tungsten, he lost his muse. The study of modern chemistry, he discovered, was more theoretical than tactile—"a colorless, scentless mathematical world":
This, for me, seemed an awful prospect, for I, at least, needed to smell and touch and feel, to place myself, my senses, in the middle of the perceptual world.
I had dreamed of becoming a chemist, but the chemistry that really stirred me was the lovingly detailed, naturalistic, descriptive chemistry of the nineteenth century, not the new chemistry of the quantum age.
This need to attain a level of maximum engagement with his work has seemed to hold true for Sacks as a neurologist as well. Personal revelations have marked the course of his professional life. From a very young age, he experienced migraine auras—the zigzag or fortification-like patterns and light that appear just before a migraine headache sets in. He came to regard the auras "as a sort of spontaneous experiment of nature, a window into the nervous system," and credits them with being one of the …


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Fridge Funny Headscratchers Main Trivia YMMV main index Narrative
He's not the Messiah! He's a very naughty boy! Monty Python's Life of Brian is a tremendously popular and very funny film by Monty Python, following the misadventures of Brian (played by Graham Chapman), who was born just down the street from Jesus Christ. Dissatisfied with his life as a Jew in Roman territory, Brian attempts to join La R�sistance (though mostly because there's a very pretty girl there) and ends up fleeing from the Romans. In the middle of this, he accidentally starts a cult, becomes a Messiah figure, gets captured by the Romans, and is crucified.Upon its release, this film drew a lot of controversy, mainly in the form of criticism from various religious groups and orders due to what was perceived as a disrespectful mockery of Jesus Christ (which in turn was frequently based on the erroneous belief that Brian was intended to be / actually was Jesus, rather than just someone whose life paralleled him in several ways). Rather than mocking Jesus, however, the film actually treats the source material with a lot of respect. It just points out that Christianity may have missed the point on some of what Jesus taught. It is not unheard of for the movie to be regarded as an Affectionate Parody by actual ministers.A made-for-TV comedy film, Holy Flying Circus, about the controversy surrounding the film was released on BBC 4 in 2011.See also Monty Python's Flying Circus.Monty Python's Life of Brian provides examples of the following tropes:
And... Always look on the bright side of death! Just before you draw your terminal breath!


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Internship - Advertising / Marketing Assistant
Bookmark This
Starbeat Intermedia, Inc.
9 Larkdale East Rd
Deerfield, IL
We are an award winning advertising agency and production house in a stage of growth and we are looking for an enthusiastic young person who has some advertising/marketing experience looking to work in the industry. We work with our clients on all elements of their advertising/marketing campaigns from strategy and media buying to creative and production; including print, online, radio and television.In this position you will gain experience coordinating client projects as well as help make sure all company projects are organized and on task. We are offering this position as an unpaid internship. Although we will be investing our time to train in hope that this position will develop into a paid position.
We are currently considering applicants for this opportunity.


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Juvenile shot in Northeast DC
October 31, 2011 - 09:54 pm
A juvenile has been taken to a hospital following a shooting in Northeast D.C.
Metropolitan Police are investigating the shooting that happened shortly before 9 p.m. in the 100 block of M St NE. Police say the victim is a juvenile male. Officers are searching for the shooter.
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Trees Infused With Glowing Nanoparticles Could Replace Streetlights
Taiwanese researchers have come up with the elegant idea of replacing streetlights with trees, by implanting their leaves with gold nanoparticles. This causes the leaves to give off a red glow, lighting the road for passersby without the need for electric power. This ingenious triple threat of an idea could simultaneously reduce carbon emissions, cut electricity costs and reduce light pollution, without sacrificing the safety that streetlights bring.
As many good things do, this discovery came about by accident when the researchers were trying to create lighting as efficient as LEDs without using the toxic, expensive phosphor powder that LEDs rely on. The gold nanoparticles, shaped like sea urchins, put into the leaves of Bacopa caroliniana plants cause chlorophyll to produce the reddish luminescence.
In an added bonus, the luminescence will cause the leaves' chloroplasts to photosynthesize, which will result in more carbon being captured from the air while the streets are lit. The next steps are to improve the efficiency of the bioluminescence and apply the technology to other biomolecules.
That's sorta stupid. Anyone caught plucking the leaves from the trees would then be arrested, and when they fall in the autumn, it'd be a free-for all. How about varieties of trees instead are genetically engineered to be bioliuminescent? You get enough of these things glowing together, and you'd have a pretty amazing little project lighting your city streets. And, in the long run it'd be less of a waste of precious metals and less costly.
Geez, Taiwan.
Where does the energy come from? If they're giving off light, it must be coming from somewhere.
If they actually give off enough light to see clearly by on the streets, that's a lot of energy, and it seems like it would be drawn from the tree's energy reserves, which could kill it.
Or if the gold nanoparticles themselves glow, wouldn't a cheaper solution be to just paint the streets and buildings with glow-in-the-dark paint?
Nonetheless, a fun idea - imagine what our Christmas trees would look like . . .
@SteelyJoe22, when you asked where the energy is coming from to give off the glow.
"The gold nanoparticles, shaped like sea urchins, put into the leaves of Bacopa caroliniana plants cause chlorophyll to produce the reddish luminescence.
In an added bonus, the luminescence will cause the leaves' chloroplasts to photosynthesize, which will result in more carbon being captured from the air while the streets are lit. The next steps are to improve the efficiency of the bioluminescence and apply the technology to other biomolecules."
I'm assuming that the natural chemical reactions in the tree itself with the addition of the gold particles creates a chemical reaction that produces bio-luminescence much like deep sea creatures that produce light from their own bodies in an area where there is none.
A tree is a living organism and must be capable of similar processes with the help of the gold...
In the linked article, they stated that the nanoparticles produce fluorescence under ultraviolet light. If you have to set up UV lights under every tree, there will be no electricity savings compared to using regular lights. The particles will glow for a little while after the sun sets, but then artificial UV sources must be brought in, or the street will go dark.
Wait. So gold+chlorophyll=red bioluminescence? does it only glow when under UV light? Or does the UV light just trigger it, then it becomes self-sustaining?
So many questions. I really wish PopSci was a little more in-depth with their articles. If they're worried about scaring off some of their less-informed readers, perhaps they could implement, on the site only (obviously), a "More Detail" feature that when clicked adds technical details to each appropriate article?
Although the idea of glowing trees sounds cool, the idea of having to implant gold nano particles into the leaves sounds like an incredible waste of time and money. I would think trying to engineer a tree that is bio-luminescent would be cheaper and easier.
hmmm..... seems like a good idea, but who on earth would want to sit there and inject nanoparticles into each and every leaf on a tree?? We need to come up with a geneticly engineered bioluminescent breed of tree. If we did that, we could plant these things left and right around trafic and whatnot, and i'd plant'um all over my yard. It would be good for the envirenment, save energy, and... well it would just be plain AWESOME! I hope that someone with the knoledge and equipment to do this decides to.
I can imagine that would have some serious environmental ramifications. The birds and insects might steer clear from it, like they do to non-native plants, not to mention how it might affect the trees themselves (it's a foreign invasive object--just like implants or any other invaders in us make our bodies try to eject them), and it would appear that you could only put them in evergreens, lest it be a waste of time when the leaves fall.
The linked article also says that the nanoparticles stimulate the red glow from the trees under ultraviolet light. First: how is setting up Black Lights for this more Sustainable than regular street lamps? How is a red glow going to be safer than focused beam lighting on streets at night? Finally, are the photos you're seeing actually from the experiment, or is it just a pretty photo from sometime during the day...that doesn't look like a red glow! And instead of that golden glow, it would be red in the cities...sounds like Nightmare on Elm Street.


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Diversity Profile
Harper College does not discriminate on the basis of race, color, religion, sex, national origin, ancestry, age, marital status, sexual orientation, disability or unfavorable discharge from military service. This policy governs the recruitment and admission of students, the recruitment and employment of faculty and staff and the operation of any of the College's programs and activities as specified by federal laws and regulations. It is also the policy of Harper College that no student or employee shall be subjected to sexual harassment, which is regarded as a form of discrimination.
Roger Spayer, Chief Human Resources Officer
Our vision is to enrich our world by educating culturally literate students who recognize the opportunities of and make positive contributions to a global society.
- We create a culture of scholarship, integrity and innovation rooted in the diversity of our Harper community.
- We inspire our Harper community to believe that there is a transformative impact when people from different world views work together collaboratively.
- We partner with our community to demonstrate that it is possible for people of all viewpoints and persuasions to respect and learn from each other.
We are committed to fully engaging the wealth of thought, backgrounds, languages and life experiences of our students, colleagues and community to foster an environment of academic excellence and student success.
Located approximately 30 minutes from downtown Chicago, Harper College is situated on 200 beautiful acres in Palatine, Illinois., Convenient to shopping, theater and cultural events, the College serves 23 communities including: Arlington Heights, Barrington, Barrington Hills, Elk Grove Village, Inverness, Lake Barrington. Mount Prospect, North Barrington, Palatine, Prospect Heights, Rolling Meadows, Schaumburg, South Barrington, Tower Lakes, Wheeling and portions of Hoffman Estates, Deer Park, Buffalo Grove, Carpentersville, Des Plaines, Roselle, and Fox River Grove.


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Submit Review
Campground Search
204479 User submitted reviews online!!
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Pine Grove, Pennsylvania
Twin Grove Resort and Campground
[ 9/10 ]
We enjoyed our stay here. Since the last time we stayed here, they have done many improvements. They have added another pool with a water slide. They have more sites. Also added a fenced dog area. The only down side is that there is not a lot of shade at this time, but they have many small trees planted so in the years to come this should be better. Have a very well stocked store. They had activities planned all day on the weekend that we stayed so the kids stayed busy and were not bored. We enjoyed our stay and would go back again.
Henderson Harbor, New York
1000 Islands / Association Island KOA
[ 9/10 ]
This was our second visit to Association Island. We have seen improvements from last year since they became a KOA campground. Yes there is a strong algae smell in the office area but we camped on the water in the H sites so the smell was not there at all. We had AT&T and Net 10 phones which got good reception. The Wi-Fi did work at our site but was a little slow at times. They do allow dogs. We didn't use the boat dock or access. They do have a pool which was very clean. One night they had a band in the club house area. Very friendly staff. We re-booked for next year.


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Tags: world series, fenway park, bush stadium, mlb, baseball, boston red sox, st louis cardinals, david ortiz, dustin pedroia, michael wacha, adam wainwright
Tags: mlb playoffs, alds, boston red sox, tampa bay rays
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This Building/Apartment just got finished being built, everything
is BRAND NEW.
Building Features:
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