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- Nationwide Installer Database
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Definition of texture mapping in English:
texture mapping
Line breaks: tex|ture map|pingnoun
- The application of patterns or images to three-dimensional graphics to enhance the realism of their surfaces.More example sentences
- Does the creature resemble a half-finished 8th grade computer graphics project without finishing touches like texture mapping or surface smoothing?
- The most fun sidebar, though, was the one headed 'Into the Third Dimension ', which discussed such modern technologies as texture mapping and color blending.
- Pixar's technical contribution to computer animation is the art of texture mapping which, like performance capture, raises the bar for what's visually achievable from storyboard to silver screen.

subset: commoncrawl


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Reading the Windows 8 tea leaves
The Taiwanese tech confab Computex has revealed the first trickle of Windows 8 hardware, offering a little clarity to the muddy waters of the operating system's future.
Most of the Windows 8 devices on display were prototypes only. Few manufacturers released detailed specs, and fewer allowed attendees to even hold the prototypes. Nevertheless, there's some important things we can glean about how the new hardware will meld with the new operating system.
First, thin is in. Way in, and that bodes well for device weight. Even Asus' unusual and unique dual-screen Taichi is expected to come in at … Read more


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MABL honors Bernadeia Johnson for courageous leadership
Monday, 18 November 2013 15:45
Minneapolis Public Schools (MPS) superintendent, Dr. Bernadeia Johnson, was honored on Saturday, Nov. 9, by the Minnesota Association of Black Lawyers (MABL) for her courageous leadership in eliminating the achievement gap for minority students in Minneapolis. Johnson received the 2013 Profiles in Courage Award, an annual recognition award bestowed on individuals who demonstrate courage and excellence in their leadership.
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Minnehaha Academy students receive academic recognition
Friday, 08 November 2013 15:58
Three Minnehaha Academy students, Aaron Williams, Zoey Twyford and Tianna Briese received recognition as National Merit Awardees. These students received the designation of National Achievement Outstanding Participants by scoring in the top 3% of more than 160,000 African-Americans who requested consideration in the 2014 National Achievement Program when they took the 2012 Preliminary SAT/National Merit Scholarship Qualifying Test.
Way to Grow and Urban Ventures announce partnership: Parent-child program for preschool-aged children and their families starts this January
Friday, 25 October 2013 15:09
In January 2014, Way to Grow will open a parent-child program for preschool-aged children and their families, called PALS (Parent-Child Activities Lead to School Readiness), on the campus of Urban Ventures, 2924 4th Ave S, Minneapolis.
Read more...
Lt. Governor Prettner Solon challenges Minnesota schools to increase breakfast access
Friday, 25 October 2013 14:02
Earlier this month, Lt. Governor Yvonne Prettner Solon served breakfast at Pillsbury Elementary School 2250 Garfield Street NE, Minneapolis, MN 5541 to raise awareness of child hunger and its impact on education. The Lt. Governor was joined by Education Commissioner Brenda Cassellius, Minneapolis School Superintendent Bernadeia Johnson, Pillsbury Principal Laura Cavender, and Ellie Lucas of Hunger Free Minnesota.
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Getting education right from the beginning
Friday, 25 October 2013 13:52
Marian Wright Edelman, NNPA Columnist
[We found that] if we created the right wraparound programs, the right preschool programs that were strong enough and rigorous enough, that fed into a rigorous pre-K through 3 program that fed into a middle school and a high school that actually works and inspired as well as prepared the child, you could have marvelous things happening . . . It all starts in the first 720 days—pre-K, K, 1, and 2. If you don't get those right, the last 720 days—grades 9, 10, 11, 12—won't be right."
–Superintendent Jerry Weast
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A unified district vision guides our new strategic planning process
Friday, 25 October 2013 12:38
Dr. Aldo Sicoli, Superintendent of Robbinsdale Area Schools
Robbinsdale Area Schools is currently updating our strategic plan for achieving our mission to inspire and educate all learners to discover their potential and positively contribute to their community. Over the past few months, we have assembled an outstanding team of community members, parents, students and staff to participate in a community planning initiative to build a plan that delivers our vision of every student graduating career and college ready.
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Minneapolis Public Schools and University of Minnesota partner to advance the development of early childhood education centers in Minneapolis
Monday, 14 October 2013 13:47
To expand access to early childhood education to Minneapolis children and families, Minneapolis Public Schools (MPS) and the University of Minnesota formalized a new partnership. The goal is to improve the overall quantity and quality of services by working together and with community partners to establish new early childhood education centers in the City of Minneapolis, beginning in North Minneapolis and eventually expanding to a second center during the next several years.
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Cedar Log Bedroom Furniture is great for cabin style homes, or for any nature lover! Natural style that makes you feel good and your bedroom look good too!
Available in queen, double, and single.
Matching Nightstand available, sold separately.
Get that log cabin feeling with a rustic log bed. Crafted from northern white cedar with natural cracking texture that does not affect the structure, yet adds to the appearance. This wood can be stained or left as natural smooth finish. This bed comes complete with headboard, footboard, and side rails. This set is brought to you by Rustic Natural Cedar, a 30 year old company that offers a 5 year limited guarantee. All of Rustic Cedar's pieces, such as this bed, are mortise and tendon joinery and easy to assemble with household tools. Sweet dreams!!
Ecologically Sound Commitment: This cedar wood is harvested from plentiful, renewable source areas, and never clear-cut. Natural log furniture is durable and outlasts most other furniture and is biodegradable, making it an environmentally friendly product. Since no chemicals are used in the finishing of this product, rest assured that it is an environmentally responsible choice of furniture.


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'The Dr Browns Deluxe Bottle Warmer is an electric steam warming system that efficiently warms baby bottles...'
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'After a traumatic time trying to find a teat my son would take i discovered mam bottles. There brilliant,...'
natesmammy - darlington
'This product is very easy to use both while feeding and cleaning afterward.'
Grandpa Jeff - Colchester
©Kiddicare 2014


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As creative director, I want my team of artists and designers to have their favorite supplies and the highest quality tools. MisterArt is the only place that I can find everything my team needs... and quickly. Orders get here quickly and service is exceptional. Best of all, the VIP discount saves our company A LOT of money, which makes the boss very happy :)
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Welcome International Customers
We're excited to share our jewelry collection with you!
Just choose your country and currency to personalize your shopping experience.
We're excited to share our jewelry collection with you!
Just choose your country and currency to personalize your shopping experience.
Item#: 782274
Faceted black agate gem trimmed with .12 ct. t.w. diamonds. Sterling silver ring.
Due to the incredible value on Ross-Simons' Outlet Pricing, no additional discounts apply.
Our 100%
Width: | 5/8 inch |
Metal: | Sterling Silver |
Finish: | Polished |
Stone 1: | Agate AGATE: a variety of chalcedony, agate covers a rainbow spectrum of colors from black and gray to brown, pink, blue and yellow. Agate can be textured and exhibit a variegated layered stripe effect, which makes it a wonderful stone for carved cameos and beaded necklaces and bracelets. (Color: Black, Quantity: 1, Shape & Cutting Style: Pear Fancy, Size: 15X10 mm) |
Stone 2: | Diamond Diamond: The hardest and most brilliant of all gemstones, a diamond can make the heart race with its pure and fiery spark. An ancient symbol of love, a diamond is the preferred gemstone for tokens of affection, such as rings, earrings, necklaces and bracelets. Diamond is the birthstone for April. (Quantity: 8, Shape & Cutting Style: Round, Color Grade: I-J, Clarity: I2-I3, Weight: 0.12 ct. t.w.) |
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Lundberg Wild Blend® Wild and Whole Grain Brown Rice -- 1 lb
Great in any dish
I like to mix this rice with their Jubilee blend. I usually use 1 cup of each rice with 4&1/4 cups of broth and I add spices that complement the dish I am making. -Like rotisserie chicken spice for chicken and rice, or steak seasoning and paprika for Spanish rice. Love everything from this brand!
July 16, 2013
Best wild rice ever
This rice cooks well - very creamy and flavorful.
March 20, 2013
Great nutrition and taste
The wild rice adds a wonderful nutty flavor and has additional nutrition that complements the brown rice well. I use this with roast chicken a lot. Great fresh taste.
December 31, 2012
I just wish the bag was bigger!
December 29, 2012
Great flavor!
December 9, 2012


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BGCI: The global network > Contact BGCI
Contact BGCIEnquiries and Feedback
ContactsBGCI UK Head OfficeDescanso House Find UsAlternatively, locate us on local Google or on Multimap The nearest stations are Kew Bridge (for trains) and Kew Gardens (for tubes and the North London Line). We are very close to Heathrow Airport. We have programme offices in China, Russia and the US.BGCI ChinaXiangying Wen BGCI China BGCI RussiaIgor Smirnov c/o Main Botanical Gardens BGCI USAndrea T. Kramer BGCI at Chicago Botanic Garden BGCI is a 501(c)(3) non-profit organization in the United States. Individual memberships and donations are tax deductible in the US to the extent provided by law when made through www.justgive.org We also have representatives in the following countries: BGCI Canarias c/o Jardín Botánico Canario Viera y Clavijo BGCI Colombia Alberto Gomez-Mejia BGCI Netherlands Bert (L.J.W.) van den Wollenberg |


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K-State High Jumper Erik Kynard will be bringing a Silver Medal back to Manhattan this fall. Kynard jumped 2.33 meters (7 feet, 9 inches) to finish in second-place by himself.
Ivan Ukhov of Russia took home the Gold Medal with a jump of 2.38 meters (7-10), while three jumpers finished at 2.29 meters to share the bronze.
Essa Mutaz Barshim of Qatar, Robert Grabaarz of Britain and Derek Drouin of Canada will share the Bronze Medal.
The 6'4" Kynard qualified for the Olympics after a second-place finish at the US Olympic Trials last month in Eugene, Oregon. He was also the 2012 NCAA Champion in the High Jump.
Jamie Nieto of the USA finished in 6th with a jump of 2.29 meters, and Jesse Williams tied for 9th with a 2.25m.
Kynard and Nieto are both coached by KSU track coach Cliff Roveto.
Kynard will be a senior at Kansas State in the coming year.


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Venice pigeons.
Various shots of the Piazza di San Marco full of pigeons. L/S domes on church. L/S pigeons perched waiting for 2 o'clock to come. M/S clock tower. M/S pigeons taking off from wall as it chimes. C/U keeper with food leaving building. M/S mass of pigeons landing...
We always welcome comments and more information about our films.
All posts are reactively checked. Libellous and abusive comments are forbidden.


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© Pittsburgh Steelers
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text: This product belongs to: Travel Tumblers Category: Theme Subcategory: New Year Ships In: 5 - 10 business days (pending credit, art, and proof approval) Material: Stainless Steel and Acrylic Dimensions: 3.2 in. W X 7 in. H Imprint Area: 8.0 in. W X 1.7 in. H Decoration Method: PadPrint, Silkscreen Weight: 0.71lb. Enjoy the easy grip feature on this BPA free tumbler. - Holds 16oz - Made of plastic - Features a non-slip grip - BPA free - First color run charge is FREE Were you able to find what you were searching for? Zero Risk ShoppingLowest Price GuaranteeIf you find a lower price, we'll give you $50 off on your next order. 100% Satisfaction Guarantee If you're not happy with your order, it's FREE. On-time Shipment Guarantee If your order does not ship on time, it's FREE. Frequently Asked Questions about this ProductQ: How do I upload artwork? A: To use a graphic located on your local computer, click on the "Upload Now" button on the "Step 1: Get Your Artwork" page of the design studio. This will lead you to a new page. Click the "Browse" button and look for the file on your computer. Q: What is your Lowest Price Guarantee and how does it work? A: We guarantee that the item you are purchasing has the lowest price in the US. Be the first to find and report to email@example.com an advertised price that is lower than what you find on our site for the same product in a given Q: Why do minimum quantities differ from product to product? A: Minimum quantity requirements vary from manufacturer to manufacturer. In cases where a manufacturer's minimum order requirement exceeds your requested quantity, a Branders.com Specialist will assist you. Call us at 1-877-272-6337. Write in your question about this product: AVAILABLE COLORSCUSTOMER REVIEWS53 reviews We were looking for an inexpensive product that had a low minimum order (we are a small company) that we could use as a "new employee" gift. The Travel Tumbler fit what we were wanting. The look of the travel mug was very appealing. Nothing that I didn't like. Product looks great. No problems. The product did not look cheap. It has not leaked and the print was done well. I did not like the gap of space between the printed words. Wish it would have been one big flow of words I liked that there are no handles, so it provides a little more stability. Can't think of anything I like least about this product. PEOPLE WHO VIEWED THIS ALSO VIEWEDMORE UPSCALELOWER PRICELOWER MINIMUMSFASTER TURN AROUND |


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18 U.S.C. 2257 Record-Keeping Requirements Compliance Statement |
All models, actors, actresses and other persons that appear in any
otherwise contained in this Website were over the age of eighteen years
at the time of the creation of such depictions.
Some visual depictions displayed on this Website are exempt from the provision of 18 U.S.C. section 2257 and 28 C.F.R. 75 because said visual depictions do not consist of depictions of conduct as specifically listed in 18 U.S.C section 2256 (2) (A) through (D), but are merely depictions of non-sexually explicit nudity, or are depictions of simulated sexual conduct, or are otherwise exempt because the visual depictions were created prior to July 3, 1995. THIS ONLINE WEBSITE WAS PRODUCED AS OF AND IS A CONTINUOUSLY ONGOING AND CHANGING PRODUCTION, THE MOST RECENT ITERATION OF WHICH IS DATED . The records required pursuant to 18 U.S.C. section 2257 and 28 C.F.R. 75 for materials contained in the Website are kept by: Pedro gpalud Avenida Simon Bolivar -Transistmica Edificio 123 Resourcing Panama City, Panama Other records required pursuant to 18 U.S.C. section 2257 and 28 C.F.R. 75 are kept by the Producer's custodian of records as follows: R. Hagen Custodian of Records Net Wave, Inc. Kingfisher Trade & Commerce Limited Stekkenbergweg 4 1105 AJ Amsterdam The Netherlands Frederic Valiquette HLV Cyberweb Solutions 5464 10e Avenue Montréal, Québec, H1Y 2G8 CANADA R. Duak 7722 Densmore Avenue Van Nuys, CA, 91406 USA Cloud9Content 512 S. Hobart Blvd. Suite #701 Los Angeles, CA, 90020 USA Callie Trotter 399 Bermuda Creek Rd Las Vegas, NV, 89123 USA Brad J. Winters 4th Floor, 52 Powell St. Vancouver, BC, V6A 1E7 Canada Falcon Foto 2740 Magnolia Blvd. Suite 201 Burbank, CA, 91505 USA C.Keddie Anker Koz 2-4 Em.4 3B Budapest, 1065 Hungary Kelly William Wright 6404 Falcon Court Tampa, FL, 33625 USA Kirkwood Entertainment Group 8306 Wilshire Blvd Ste. 783 Beverly Hills, CA, 90211 USA Klimaxxx Productions 77-775 Jackal Drive, Suite E Bermuda Dunes, CA , 92211 USA Norman Bentley 23403 Lake Manor Drive Chatsworth, CA, 91311 USA Mcall Images 23300 Clarendon Street Woodland Hills, CA, 91367 USA OUNIQUE INC. Jeff White 6240 Mulholland Hwy Los Angeles, CA, 90068 USA John H. Copeland 302 East Carson Avenue Suite 400 Las Vegas, Nevada, 89101 USA Pure Candy Images Inc. 1802 N Carson St. Uite#212-2173 Carson City, NV USA Robert Tepper President CD ROM Distributors, Inc./ RGT Productions/ X-COM Productions 300 Oak Street Suite 150 Pembroke, MA, 02359 USA S. Caron Apt#29, Alfaz Del Pl. Alicante Espana SELECT WEB PICS 1595 Cove Lake Rd. North Lauderdale, IL, 33068 USA B. Shaw Cabo Entertainment Group Inc. 3430 E. Russell Rd #309 Las Vegas, NV 89120 USA CD-ROM Distributors/ST Productions, 100 Corporate Park Drive, Suite 1690 Pembroke, MA 02359 USA S Walker 8704 Santa Monica Blvd PH2 Los Angeles, CA USA David Trotter, International Glamor 120 Copeland Rd, Suite 264 Atlanta, Georgia 30342 USA |


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After penalizing Interflora and UK newspapers, Google has issued a stern warning that selling links on sites that pass PageRank can lead to a penalty in Google. Google specifically called this a "reminder," because in 2007, they clearly went on record that selling paid links can lead to a penalty.
Google's Matt Cutts, the head of search spam, specifically called out the techniques believed to have resulted in the penalties leading to the PageRank drop of the UK newspapers and the ranking drop of the huge UK floral company Interflora. Cutts called out advertorials specifically in his warning.
Cutts wrote:
Please be wary if someone approaches you and wants to pay you for links or "advertorial" pages on your site that pass PageRank. Selling links (or entire advertorial pages with embedded links) that pass PageRank violates our quality guidelines, and Google does take action on such violations. The consequences for a linkselling site start with losing trust in Google's search results, as well as reduction of the site's visible PageRank in the Google Toolbar. The consequences can also include lower rankings for that site in Google's search results.
Cutts goes on to explain that if you do get caught, Google will most likely send you a notification via webmaster tools. Then it is up to you to take action by removing the paid links from your site and submitting a reconsideration request.
For more details on where this warning came from, see our two stories from earlier today:
- Google Says No Comment On Why Interflora Was Penalized
- Google Dishes Out PageRank Penalties To UK Newspaper Web Sites For Selling Links
Related Topics: Channel: SEO | Google: SEO | Google: Web Search | Top News


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Mobile Email MyUNIverse eLearning A-Z Index Calendar Directory Contact Employment Visit UNI
Executive Vice President and Provost
Chemistry "Halloween House"
Submitted by Anonymous on Fri, 10/26/2012 - 3:30pmUNI student affiliates of the American Chemical Society (ACS) will host a "Halloween House". There will be a variety of Halloween-themed demonstrations in rooms such as the "Devil's Den," "Frankenstein's Lab," "Mummy's Yummies" and "Grossology Lab." The event is free and invites children of all ages. UNI students in costume will help children with hands-on chemistry activities, such as making liquid-nitrogen ice cream and gak. Halloween House is held in conjunction with National Chemistry Week and is a program of the ACS designed to reach the public with a positive message about chemistry.
Humans vs. Zombies
Submitted by Anonymous on Fri, 10/26/2012 - 4:01amThis is a campus-wide game of tag sponsored by the Rod Library.
Observatory Show
Submitted by Anonymous on Thu, 10/25/2012 - 8:00pmVisit the UNI Observatory to learn about the objects in the night sky and view the planets through the Earth Science telescope. Free and open to the public. Meet near the polar bear outside of 137 McCollum Science Hall before 9 p.m. Late arrivals will not be admitted.
Guest Artist Recital: Evan Smith, saxophone
Submitted by music on Thu, 10/25/2012 - 7:00pmVisiting artist Evan Smith will present a saxophone recital with faculty artist Robin Guy, piano. Evan Smith is an active performer on saxophone, an experienced educator and a proponent of new music. Smith attended the University of Northern Iowa, earning undergraduate degrees in Saxophone Performance and Music Education, as well as James Madison University where he earned a Master's of Music in Saxophone Performance. This event is free and open to the public.
Strayer-Wood Theatre comedy: "November"
Submitted by Anonymous on Thu, 10/25/2012 - 6:30pmUnder the direction of Jay Edelnant, David Mamet's fiendishly funny, over-the-top comedy November offers no mercy in its satirical stab at American politics. Meet President Charles Smith, the most corrupt, inept hack ever to sit in the Oval Office. It's the final days of his bid for a second term, but the country is a mess and his poll numbers are "lower than Gandhi's cholesterol." Toss in a lesbian speechwriter longing to marry her sweetheart on national television, a cynical chief of staff, Thanksgiving turkeys awaiting pardon, and enough shady backroom scheming to make even Bernie Madoff blush, and you've got an ideal way to gear up for the 2012 election.
Shine the Light on Domestic & Sexual Violence
Submitted by Anonymous on Thu, 10/25/2012 - 5:30pmLearn more about domestic and sexual violence, and find out how both men and women can prevent violence. Speakers include: Lisa Ambrose, substance abuse & domestic violence advocate from Seeds of Hope; Jessica, a survivor of domestic violence; Casey Herkelman, crisis services director from Cedar Valley Friends of the Family; and Alan Heisterkamp, director of the Mentors in Violence Prevention Leadership Institute at UNI's Center for Violence Prevention. The evening will end by "shining the light on violence" while viewing The Clothesline Project Display. Flashlights provided. Faculty, staff, students and the public are invited.
Final Thursday Reading Series: Mary Swander & Farmscape Book Release
Submitted by Anonymous on Thu, 10/25/2012 - 5:00pmFTRS presents Mary Swander, the Poet Laureate of Iowa, for a special book release event. Farmscape: the Changing Rural Environment brings together the script of Swander's docudrama, Farmscape, along with selected essays on the play and on the state of rural America. A reception begins at 6 p.m., followed by open mic at 7 p.m.; Swander takes the stage at 8 p.m.
Ethics in Science Communications
Submitted by Anonymous on Thu, 10/25/2012 - 4:00pmOffice of Sponsored Programs will be hosting a lecture on "Ethics in Science Communications" by Clark Wolf from Iowa State University. He will be providing a lecture on ethical issues involved in how scientists communicate with the public about their research. All are welcome. This event is being co-sponsored by OSP and the College of Humanities and Fine Arts and will be held in CME.
The Clothesline Project Display
Submitted by Anonymous on Thu, 10/25/2012 - 10:00amThe Clothesline Project is an artistic visual representation of the pervasiveness of violence against women, the LGBTQ community and other marginalized groups. Originally started in Cape Cod, Mass., Clothesline Projects have sprung up throughout the United States and around the world as a way for survivors and allies against violence to express their emotions and feelings by decorating t-shirts.
UNI Percussion Department Concert
Submitted by music on Wed, 10/24/2012 - 7:00pmUnder the direction of percussion professor Randy Hogancamp and percussion instructor Matthew Andreini, the UNI Percussion, Marimba, West African Drum and Kaji-Daiko (Taiko) Ensembles will offer their fall concert. This event is free and open to the public.


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Port Washington Branch Track Inspection May 10 - Buses Replace Some Trains
The MTA Long Island Rail Road will provide bus service in place of four overnight trains on the Port Washington Branch between Great Neck and Port Washington on Saturday, May 10 in order to use the Sperry Rail Car to conduct special rail tests. Two eastbound and two westbound trains will be affected. Customers should allow up to 30 minutes additional travel time.
The Sperry Rail Car, a bright yellow vehicle fitted with ultrasonic and induction test equipment, is designed to detect internal rail defects not readily visible to the eye. Defects that are found will be corrected immediately by a crew of LIRR track maintenance workers. The Sperry Rail Car is used twice a year to inspect approximately 500 miles of LIRR track.
Customers on the 12:19 AM and 1:19 AM trains from Penn Station will transfer to buses at Great Neck to complete their trips to Manhasset, Plandome or Port Washington Stations.
Customers on the 1:40 AM and 3:40 AM trains from Port Washington will board buses at their stations, Port Washington, Plandome and Manhasset, and then transfer to trains at Great Neck to complete their trips.
- Google Translate


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Your location: Home > Press > News Archive
Royal Society and US National Academy of Sciences release joint publication on climate change27 February 2014 The Royal Society and the US National Academy of Sciences have released a joint publication that explains the clear evidence that humans are causing the climate to change, and that addresses a variety of other key questions commonly asked about climate change science. More
Climate talks in Paris look promising25 February 2014 The wild weather being witnessed across the globe - from Australia's hottest summer to Britain's wettest winter - is spelling out some of the sobering impacts facing everyone from unchecked climate change. In a joint editorial, UNFCCC Executive Secretary Christiana Figueres and Paul Polman, Chief Executive Officer of Unilever, talk about how the unprecedented impacts are a wake-up call to all of us. More
UN kicks off International Year to raise profile of small island developing countries 24 February 2014 While drawing attention to some of the most beautiful beaches in the world, the International Year of Small Island Developing States – which kicked off today at the United Nations – is also a chance to address increasing environmental degradation, and social and economic marginalization in those countries. More
High-level ministerial engagement at the June sessions 10 February 2014 The high-level ministerial round table on increased ambition of Kyoto Protocol commitments (mandated by Decision 1/CMP.8, para. 10) will take place on Thursday 5 June. The high-level ministerial dialogue on the Durban Platform for Enhanced Action (mandated by Decision 1/CP.19, para. 7) will take place on Friday 6 June. Further information on these events will be made available soon. The COP 19/CMP 9 President, Mr. Marcin Korolec, will preside over these two high-level events.
© 2014 United Nations Framework Convention on Climate Change


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Something Bad Must Be Going To HappenModerator: Team Cub
Forum rules
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• Page 1 of 1
Something Bad Must Be Going To HappenHi to all my Cub Friends. After a few weeks of sickness and a few trips to the emergency room and Dr. last week with my wife, we both got up feeling pretty good today. I just got up from the table eating some hot biscuits, blackberries, fried ham, grits, and fresh cows milk. And, of course, a pot of coffee. The weather is beautiful so I am going to try to move around a little today and maybe finish repairing my old friends two Cubs for him. My little garden spot is still a little too wet to plow, but my neighbor said he would plow it for me when I'm ready, so I may have a spring garden after all. ( I can't fight the steering wheel any more ) I have 9 new Martin boxes up so am looking forward to sitting on the deck with a cup of coffee watching them. Life is good.
Enjoy your day I have to work today....maybe get some tractor work done tomorrow afternoon and Monday. Expect good things to happen, and they will That breakfast sounds GREAT Got any left I have not gotten my martin house up yet.....I better hurry, the scouts are on the way. "Never forget where it is you come from, or you may find yourself someplace you don't want to be"
Greg Norman
Merlin, you reminded me of a story:
An older couple was laying in bed one morning after a particullary good night sleep. He reaches over and takes hold of her hand. Don't touch me, she says. Why? Because I'm dead! Dead? Yes, I'm dead! How can you be dead, we're laying here talking, and I'm holding your hand? When I woke up, nothing hurt, so I must be dead!! "The Constitution is not an instrument for the government
to restrain the people, it is an instrument for the people to restrain the government lest it come to dominate our lives and interests." Patrick Henry
Merlin, It was just about a year ago that we met and had coffee at your house! Time sure flies! I really enjoyed meeting you and having coffee together. Best wishes my friend.
If you can't fix it with a hammer, you've got an electrical problem. My wife says I don't listen to her. - - - - - - - - Or something like that! http://www.cubtug.com
Come on back Bigdog and we will drink some more. I don't drink as much as I used to though. I'm down to about 2 dozen cups a day now. The weather is beautiful. One of my Mayhaw trees are in full bloom and the other ones are budding like crazy. Hope we don't get any more hard freezes. Mayhaw jelly is the only kind I like.
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Are Republicans and Democrats the Same? Bush's Lies Campaign Finance Citizens United Campaigns and Elections Conservatives and the American Right Electoral Politics Electoral Reform Lobbies Political Action Committees Political Analysis Polling and Opinion Surveys Presidential Campaigns and Elections Rural Issues Secrecy in the Bush Administration Soft Money Tea Party The Breakdown The Left Third Party Politics
I don't have simplistic fantasies about being rescued from oppression by figureheads alone. But I also know that women and people of color are a threat to the status quo.
It's the height of hypocrisy: They call for repeal of the law but plead for its dollars on behalf of constituents.
A new history of the party is too close to its subject, and misses the human drama.
With a two-seat gain while chair of the DSCC and a successful effort to get a budget through the Senate under her belt, Patty Murray has become a major force in the Senate.
Feminism is not any single person or outcome, it's a practice, and a far more active one than Valenti gives credit for.
Liberalism—including much of what's published in this magazine—seems well-intentioned but inadequate. The solution lies in the re-emergence of American radicalism.
Washington institutions esteemed for their independent scholarship don't disclose donations from corporations and foreign governments.
The neoconservative leading the fight over the legacy of Vatican II in the American Church.
It's absurd to expect agency auditors to sort out confusing, outdated campaign finance laws and regulations.
The governor needs to peddle a moderate image to win re-election in New Jersey, but on everything from reproductive rights to the environment to austerity, he's very conservative.


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Q: How is Broward Health's policy regarding smoke changing? The Board of Commissioners approved the policy to become a smoke-free campus effective January 1, 2014. This means that when the policy goes into effect, smoking will no longer be permitted anywhere on campus and the current designated smoking areas will be eliminated.
Q: Why are our campuses going smoke free? By eliminating second-hand smoke on our campuses, Broward Health is emphasizing its commitment to providing a healthy environment for employees and our community. Establishing a smoke-free campus policy will:
This decision supports the rights and privileges of both smokers and non-smokers alike.
Q: Are other hospitals adopting smoke-free policies? Many of our surrounding hospitals have adopted a smoke-free policy with the trend steadily increasing.
Q: Are you considering the needs and perspectives of all different groups? Broward Health is committed to having all groups represented in the implementation process, and in providing mechanisms for people to voice their ideas and concerns. A successful transition of the organization must evaluate the three main populations that will be subject to this rule: 1- employees, medical staff and all contracted services; 2- patients; and 3- visitors. The policy will ultimately impact all persons who present at any Broward Health facility for any purpose. Information will be shared through the Regional Star Response Counsels, Town Halls, Rounds and Star Publication to inform all members of the workforce about the decision to become smoke-free. This information will provide opportunities to encourage employee feedback and input.
Q: Isn't tobacco-use a personal right? Tobacco is a legal product for adults. Broward Health is not forcing anyone to discontinue tobacco-use, however resources and education will be provided in an effort to encourage healthy choices. Broward Health can establish policies for its employees which protect the health and wellness of all employees and all who present at our facility. A smoke-free policy does not prohibit tobacco use; it merely establishes where use can occur. The new policy supports the right of all people on the campus to breathe smoke-free air. The simple reason for our policy is respect for each other and the environment. Employees who choose to continue smoking must do so away from a Broward Health facility.
Q: What about the use of electronic cigarettes? Electronic cigarettes, also known as E-Cigarettes, are battery-operated products designed to deliver nicotine, flavor and other chemicals. E-Cigarettes are NOT permitted under the smoke-free campus policy. Read more about them here.
Q: Is secondhand smoke (SHS) really that much of a problem? Secondhand smoke, also called involuntary smoking or passive smoking, is the third leading cause of preventable death in the United States. It is a mixture of gases and fine particles that includes:
According to the Centers for Disease Control:
The 2006 Surgeon General's report found that even brief exposures to secondhand smoke may have adverse effects on the heart and respiratory systems and increase the severity of asthma attacks, especially in children. Recent research indicates that people inhaling smoke at an outdoor café or other outside venue can breathe in wisps of smoke that are many times more concentrated than normal background air pollution levels. Aside from the risk to the general community, secondhand smoke is particularly dangerous for people with cardiovascular disease, respiratory conditions such as asthma, COPD and certain allergies, older adults, pregnant women, and children. Our medical staff community believes that secondhand smoke is a problem and led the initiative to secure Board approval of the policy to become a smoke-free organization.
Q: How will people know where they can and cannot smoke? All Broward Health campuses will be smoke-free. Reasonable communication will be provided to all impacted persons. Signage will be posted at all building/facility entrances and parking lots. Reminders from staff and security will be provided as necessary.
Q: Will there be designated smoking areas on campus? No, the current designated smoking areas will be eliminated as smoking does not support our initiative and is therefore prohibited on all Broward Health campuses. Allowing for designated smoking areas undermines the new policy. The purpose of the policy is to create a health-supporting community for everyone, smokers and non-smokers alike.
Q: What about events that occur at Broward Health facilities? All events occurring on any Broward Health facility will be covered by the smoke-free policy.
Q: Will staff or visitors be able to smoke on public property adjoining our property, such as a public sidewalk? Yes, but we ask that our employees respect our neighbors and their property.
Q: How will the policy be enforced for the various categories of impacted persons? Working committees will be determining the best way to enforce the smoke-free policy for any given group or category in a way that is based on mutual respect and which builds a smoke-free culture on our campuses. As a healthcare organization, education will be instrumental to implementing this policy. We will communicate specific details about how the smoke-free policy will be enforced when that information is available.
Q: What opportunities will be available to assist employees to stop smoking? Broward Health is dedicated to assisting employees who wish to stop smoking and eliminate tobacco use. This information will be available in our Smoking Cessation Resource Guide, on the intranet, as well as in resource racks in the cafeterias and Regional HR Offices. The Employee Assistance Program (EAP) will be available to assist employees in obtaining resources for smoking cessation.
Q: Are employees allowed to use nicotine-replacement therapy products, like gum, lozenges, or patches, at work? Employees who smoke may choose to use nicotine-replacement therapy products particularly gum or lozenges to manage their nicotine cravings during work hours. However, physician consultation is necessary for appropriate dosing and use.
Q: How will the policy be communicated to the employees, medical staff, patients and visitors? Communication regarding the new policy will be consistent and ongoing.
Employees will initially be advised about the policy by leadership's communication of the policy and transition plan. The President will provide employees with a statement of the policy change, as well as send electronic communications and intranet publications. Regional leadership will communicate and discuss the policy and transition plan during numerous opportunities such as Star Response Councils, Town Halls, rounds, and the Star employee publication.
The Chief Medical Officer and regional leadership will communicate the policy and transition plan to all medical staff and allied health professionals to elicit opportunities for dialogue and input through Chiefs of staff, physician portal, Medical Counsel and general meetings.
The Chief Medical Officer along with Regional Chief Nursing Officers, Medical Staff, Pharmacy and other applicable disciplines will develop clinical protocols to address patient needs.
The Contracts Department will communicate the policy to providers, vendors, travelers/agency and other contractors by incorporating the policy terms into the agreements if necessary.
Department of Learning will advise faculty during their annual mandatory student affiliation meetings of the policy and implementation plans for students. Students will also be informed through orientation.
Regional Volunteer Coordinators will communicate the policy and implementation to volunteers.
Marketing Services will provide community press releases to educate the community. Signage and printed materials will also assist in informing the community of the policy implementation.
Employees will have access to the Broward Health smoke free web page via a "smoke free" icon on MyPlace. This link will connect employees to information and announcements regarding the smoke-free workplace policy. As information becomes available it will be posted there. This site will be a way to access details about the smoke-free workplace policy, related activities and available resources, such as cessation materials, classes, etc. It will also be the location to ask questions, report concerns and provide overall feedback.
Q: Can I smoke in my car? Smoking is prohibited in cars parked on all Broward Health property.
Q: Where can I go to smoke or use tobacco products? Providing a place to smoke does not support Broward Health's goal to create a healthier environment. If you need to smoke, you will need to leave Broward Health property. Employees who leave the campus to smoke are encouraged to be considerate of neighbors and others in our community and must abide by Broward Health's time & attendance policy.
Q: I have ideas or concerns. Who should I contact? Anyone interested in providing feedback, submitting ideas or expressing concerns should contact the Employee Assistance Program Department via phone at 954-847-4327 or by e-mail at email@example.com. The EAP department will assist you in obtaining answers to your questions or concerns. Click here for the Smoking Cessation Employee Resource Guide.
Q: I am interested in helping with smoke-free efforts on campus. Who should I contact? Employees interested in assisting with the smoke-free efforts at their regions should contact their regional HR Director.


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Quick Facts
- NAME: Wilhelm Grimm
- OCCUPATION: Author
- BIRTH DATE: February 24, 1786
- DEATH DATE: December 16, 1859
- EDUCATION: University of Marburg
- PLACE OF BIRTH: Hanau, Germany
- PLACE OF DEATH: Berlin, Germany
- Full Name: Wilhelm Carl Grimm
- AKA: Wilhelm Grimm
Best Known For
Wilhelm Grimm was a 19th century German author who, along with brother Jacob, published Grimms' Fairy Tales, a collection famous for stories like Cinderella and Rapunzel.
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Play NowWilhelm Grimm. (2014). The Biography Channel website. Retrieved 01:33, Mar 10, 2014, from http://www.biography.com/people/wilhelm-grimm-21085173.
Wilhelm Grimm. [Internet]. 2014. The Biography Channel website. Available from: http://www.biography.com/people/wilhelm-grimm-21085173 [Accessed 10 Mar 2014].
"Wilhelm Grimm." 2014. The Biography Channel website. Mar 10 2014, 01:33 http://www.biography.com/people/wilhelm-grimm-21085173.
"Wilhelm Grimm," The Biography Channel website, 2014, http://www.biography.com/people/wilhelm-grimm-21085173 [accessed Mar 10, 2014].
"Wilhelm Grimm," The Biography Channel website, http://www.biography.com/people/wilhelm-grimm-21085173 (accessed Mar 10, 2014).
Wilhelm Grimm [Internet]. The Biography Channel website; 2014 [cited 2014 Mar 10] Available from: http://www.biography.com/people/wilhelm-grimm-21085173.
Wilhelm Grimm, http://www.biography.com/people/wilhelm-grimm-21085173 (last visited Mar 10, 2014).
Wilhelm Grimm. The Biography Channel website. 2014. Available at: http://www.biography.com/people/wilhelm-grimm-21085173. Accessed Mar 10, 2014.
Wilhelm Grimm was born on February 24, 1786, in Hanau, Germany. He and older brother Jacob studied German folklore and oral traditions, publishing a collection of stories eventually known as Grimms' Fairy Tales which includes narratives like Briar Rose and Little Red Riding Hood. Wilhelm oversaw editorial work on future editions of the collection, which became more geared towards children.
Early Life
Wilhelm Carl Grimm was born on February 24, 1786, in the town of Hanau, Germany, to Dorothea and Philipp Grimm. Wilhelm Grimm was the second oldest of six siblings, and would later embark on an industrious writing and scholarly career with his older brother, Jacob.
Wilhelm and Jacob studied law at the University of Marburg from 1802 to 1806, following the path of their lawyer father. Due to health issues, Wilhelm didn't start regular employment until 1814, when he obtained a position as secretary at a royal library in Kassel, Germany. Jacob Grimm would join him there in 1816.
'Grimms' Fairy Tales'
Influenced by German Romanticism, a prevailing movement of the time, the brothers robustly studied the folklore of their region, with an emphasis on recording village oral storytelling that was vanishing with the advent of new technology. Jacob's and Wilhelm's work culminated in the book Kinder-und Hausmärchen (Children's and Household Tales), the first volume of which was published in 1812. A second volume followed in 1815. The collection would later come to be known as Grimms' Fairy Tales, with famous stories that include Snow White, Hansel and Gretel, The Golden Goose, Little Red Riding Hood and Cinderella.
Despite the emphasis on village oral traditions, the stories were in fact an amalgamation of oral and previously printed fairy tales, as well as information shared by friends, family members and acquaintances, with non-German influences. For instance, French writer Charles Perrault had earlier written a version of The Sleeping Beauty, known as Briar Rose in the Grimm collection.
The brothers aimed to make the collection more palatable to children by its second edition, and hence made note that they had altered and expanded the language of the stories. Wilhelm, seen as the more easygoing of the two with a passion for the arts, served as editor on future editions of Tales.
Marriage and Later Years
While Jacob remained single, in the mid-1820s, Wilhelm married Dortchen Wild, with whom he would have four children.
By 1830, the brothers had taken on work at the University of Göttingen, with Wilhelm becoming an assistant librarian. The two left the university in the mid-1830s—the result of being banished by the king of Hanover after they protested changes he'd made to the region's constitution.
In 1840, the brothers decided to settle in Berlin, Germany, where they became members of the Royal Academy of Science and lectured at university. They subsequently took on a massive project—a comprehensive dictionary of the German language.
profile name: Wilhelm Grimm profile occupation:
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Famous Fiction Authors
Like in Gone With the Wind, The Sun Also Rises after Twilight, even in a Pet Cemetary Where the Wild Things Are. But let's not be too morbid and discuss creepy things like The Satanic Verses or try to get an Interview With a Vampire from The Stranger Who Professes 'I Know Why the Caged Bird Sings.' Going round in round like this, you may never know Where the Sidewalk Ends, and that would be unfortunate since Uncle Tom's Cabin is just around the corner...
Okay, we could go on, but we won't torture you. You get the point. Our attempt at creative writing is nothing compared to the imaginative minds of our Famous Fiction Authors Group.
Famous Fiction Authors 417 people in this group
Famous Germans 175 people in this group


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3G/4G/WiFi Signal & Speed Maps
5,000,000 - 10,000,000 downloads
- Free
- Crowd sourced world wide project
- It's quite a useful app
- Battery draining
Open Signal Maps is a world wide project to map signal sources.
Please, first at all check Open Signal Maps homepage.
This app looks for the nearest towers around you. It's really useful if you are in a place nearly out of range and you need to know which way you have to walk toward in order to get better signal. In a populated city, where at least two or three towers are around you at any time, it's more a curiosity than anything else.
When you activate this app, you're collaborating with Open Signal Maps, a project to map all the cellphone signals worldwide. Useful if you plan to travel to God-knows-where and you don't know if there'll be 3G there or not, or which carriers work and so on.
NOTE: For people upgrading, some *permissions* are being listed as new which are not in the app, this is a Android bug, check the permissions in your phone settings to confirm these permissions are absent. See https://code.google.com/p/android/issues/detail?id=63898
NB We never access or read your messages or contacts list. We only need that permission to count your calls and texts to help you keep track of usage.
✓ Signal compass points you in the direction your signal is coming from, just walk towards it!
✓ WiFi map allows you to easily locate nearby public networks.
✓ Coverage maps allow you see the best places for signal.
✓ Speedtest feature allows you to see the true speed of your connection.
✓ NetworkRank allows you to see which carrier is best in your area.
✓ Keep track of your monthly data, text and voice usage so you don't go over your limit.
✓ See a map of local cell towers.
✓ Help improve our coverage and WiFi maps.
✓ Share your findings on twitter and Facebook and compare your connection with other users.
✓ View your history of signal readings.
✓ Save your data to SD card.
✓ Signal booster for compatible phones
Help contribute to our crowdsourced impartial maps of carrier coverage and wireless hotspots by using our app to improve your connection.
Based on our community-generated data we are able to help keep you better connected by giving you a practical solution to the problems of slow mobile internet and dropped calls. Simply follow our signal compass to walk towards better phone signal or see our in-app coverage maps to work out which carrier is best for where you are, useful if you're thinking about changing. Our wifi maps help you find local public-access wireless networks (WAPs), helpful if you're travelling abroad or just want to find a local cafe with free wifi. Our Stats tab helps you to keep track of your usage, so there's no danger of you going over your plan limit on data, voice or text. (NB – this is why the app needs permission to access contacts and SMS, these are the permissions needed to count calls and texts, messages are never accessed or read!). Slow mobile internet? Whatsapp or BBM not working? Can't make that crucial skype call? Facebook, Instagram or Twitter too slow to be enjoyable? Run a speedtest to see the real speed of your connection, use the signal booster compass to get a better connection or use our maps to find the nearest free wifi!
Best of all, every time you use the app you're helping to improve it! By helping us to expand our wifi database and improve our coverage maps you're making the app work better and everyone else who uses it.
The best tactic for getting better signal is to follow the signal compass.
Maps not updated in real-time. Don't worry though, we log the information you share with us to improve our coverage maps and signal information. We're working hard to make sure the data you contribute to the project is available to everyone as quickly as possible.
- Not all towers and wireless routers are in our database - we're working on it!
- Verizon & Sprint users will see only one connected tower at a time
- Moving in the direction of your cell tower will not always improve reception due to interference effects/local geography.
- Data is crowd sourced - wireless and antenna locations are calculated by triangulation.
Advanced notes:
- For GSM, cell tower are identified via cell id and location area code (CID and LAC)
- For CDMA (Verizon, Sprint), cell towers are identified via Network ID, Base sub-station ID and system ID (NID, BSSID and SID).
Formerly: opensignalmaps
We map- Coverage and Speed tests for Verizon, Sprint, Vodafone, EE, AT&T, O2, 3, TIM, T-Mobile, Telcel, I WInd, SFR, Wifi and more
For those upgrading to Android 4.4.2 some permissions are being incorrectly marked as new [confirmed bug] e.g:
- save to USB has been in the app 3 years to allow saving speed test & cell data to CSV
- contacts permission has been removed, you should be able to confirm this in System Settings/Applications so we do not know why this permission is appearing
We NEVER read the contacts log or SMS content, we just count messages/calls to help keep track of your plan, you can turn off this feature.
Some lists where this application appears: Signal Tools, Reviewed by Peter Warrior, Maps, mkl apps, Reviewed by Anna Grace.
One of the kind
Good aps very useful, thank you
Does exactly what it says!
Has a wealth of information about coverage in your area. Refresh is useful when the phone fails to pass over to a new cell while travelling.
Very interesting app...
Network ranking is not accurr, unit is wrong and My Plan function is not working at all


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by Chris Owen (RSS feed) (1 year ago)
Mar 8th, 2013 at 3:00PM: Astronomers are calling 2013 "the year of the comet" as the first of two comets set to swing by Earth comes within view of the naked eye. Some avid sky watchers may be viewing with binoculars. Others may get an even closer view, thanks to a German travel agency. On March 16, Eclipse Travel of Bonn, Germany, will have Air Berlin's flight 1000 full of stargazers, giving them two hours closer...Click on a label to read posts from that part of the world.


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blank Jessica Smith
Jessica was in and out of the varsity last year, and she plans on consistently staying there in 2006 ... She has had a fine summer build up and should be greatly improved ... During track Jessica competed in the steeplechase, where she improved almost 30 seconds last season ... While at Faquier High School, Jessica claimed a District 300m hurdle title in track and was also all-state in the 4x400 relay ... Her 5K PR is 19:52 ... Jessica was born March 17, 1986 to Stephan and Leslee Smith. WHY/HOW DID YOU START RUNNING? "I used to race the boys in elementary school and beat them. In high school that changed, but I had grown to love racing against myself, so here I am!" FAVORITE TUNES TO LISTEN TO WHEN RUNNING? "Anger management music - hard rock." Jessica Smith


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Xbox 360
This page contains Final Fantasy 13-2 Unlockables for Xbox 360 called "Serah Farron XMB Theme" and has been posted or updated on Jan 17, 2012 by Inuyashaiznum1. Let us know what you think of this Unlockable by thumbs voting.
- Developer: Square Enix
- Publisher: Square Enix
- Genre: Role-Playing Console-style RPG
- Release Date: Jan 31, 2012
- ESRB: Teen
Serah Farron XMB Theme
To unlock Serah Farron XMB Theme you need to get the "Defragmented" Trophy.
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This area is dedicated for teachers who are part of the teachers' network (WP3). A warm welcome! Only by logging in you can take part of the Forum, add information about yourself on your profile, write on other teachers' wall and more!
eQNet is co-sponsoring the 8th Educational Repositories (EdReNe) Seminar, taking place on 7-8 May in Lisbon, Portugal. EdReNe is a thematic network, bringing together web-based repositories of learning resources with content owners and other educational stakeholder, in order to share, develop, and document procedures, experiences, and strategies, on the organisation and functionality of online repositories.
eQNet partners will present on the travel well criteria of online resources, describing experiences of applying travel well criteria to improve the content quality of the Learning Resources Exchange for Schools. The event is organised by the DGIDC – the Portuguese Ministry of Education. For more information on the seminar, see edrene.org.


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Nikon D300s
AF Micro-Nikkor 60mm f/2.8D
macro, micro, nikon, black and white, b w, gimp, freebsd, unix, sausage, food
This is very interesting!!
WOW! Amazing splash of oil.Fabulous capture! Hope you didn't get oil on your lens.
lol. incredible!
you have a unique way of looking at things. Cool shot


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The bus rolled out of Britton at 3 a.m. loaded with 12 women, most of whom were serious about their Black Friday shopping.
At 8:14 a.m., after a handful of stops, it rolled into the IHOP parking lot in Aberdeen.
A bite to eat at the last stop before heading home for a little nap, perhaps? No chance of that. There was more shopping to be done, and nobody had to be back to Britton until 5 p.m.
Lori Greenmyer of Brittonwas one of the riders on the bus, which also tugged a trailer to store the day's loot. She said the bus belonged to a friend. The riders all kicked in gas money to help fund the shopping excursion.
Lynda Luttrell of Britton was the driver. She said the group takes the bus on two excursions a year, usually to Aberdeen or Fargo, N.D. The gang has even gone to Rapid City before for a little vacation that included, of course, some shopping, she said.
Luttrell said she doesn't particularly enjoy shopping. But that didn't stop her from making a large purchase Friday morning. She opened the door to the trailer to reveal a massive safe. There was plenty of room left in the trailer, but there were plenty more stops to make, the women said.
Rhonda Wade of Britton said this Black Friday trek is short compared to last year's. Then, they left Britton at 8:30 p.m. on Thanksgiving and got home at 5 p.m. on Black Friday.
Friday morning crowds at stores seemed tamer than last year, perhaps because opening hours were spread out, Greenmyer said.
Luttrell called last year's scene a mad house. People were better behaved this year, she said. Wade said she didn't see any people acting rude or crabby.
The holiday spirit, or perhaps some holiday spirits, had apparently set in as people set out to shop after their Thanksgiving dinner. At stores across Aberdeen, folks found a wide variety of items they were shopping for — some for everyday use, some that will become Christmas gifts. Here are some of the favorite finds shoppers procured at various stores during their outings Thursday night and Friday morning:
Name: Lynda Luttrell, Britton
Time she started shopping: Left Britton at 3 a.m. Friday
Time of photo: 8:22 a.m. Friday
Location: IHOP
Find: During a breakfast break at IHOP, Luttrell rests on a large safe she bought earlier in the morning. She was one of 12 women who came on a bus from Britton. The safe was in a trailer behind the bus.
Name: Gentry Gauer, Aberdeen
Time he started shopping: 4 a.m. Friday
Time of photo: 6:14 a.m. Friday


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What other readers are saying about this title:
justmari said:
I have to say that "We Ain't the Brontes" was an excellent read! I never imagined a novel that could be written to my own lifestyle. My husband of thirty years walked out on us and also chose a younger woman. We haven't gotten back together but just reading this story gave me a bit of hope. Thanks and mad shout out's to Ms. McMillan on this storyline and staying intouch with her readers. I will most definitely checking out your other works.
posted Feb 23, 2012 at 3:29PM
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"Click It or Ticket" Campaign Kicks Off
Posted: 9:04 AM May 19, 2012
Reporter: BPD Press Release
According to the National Highway Traffic Safety Administration (NHTSA): -
Ø In 2010, 22,187 vehicle occupants were killed in crashes, 51% were NOT wearing seat belts at the time of the crash.
Ø Teens and young adults ages 18-34 years old are less likely to wear seat belts and are at the greatest risk of injury or death.
Ø On any given day about 38 people who are NOT buckled up are killed in motor vehicle crashes.
Ø One out of every five drivers will be involved in a crash this year.
Ø Seat belts save lives!
Remember, all passengers, even adults, in the back seat must be buckled up. Children younger than 8 years old have to ride in a child safety seat or booster seat unless they are taller than 4 feet 9 inches. The average cost of a seat belt violation is $150.
Your local Law Enforcement agencies will join other Law Enforcement officers from across the State of Texas to step up enforcement of the state's safety belt laws between May 21 and June 3, including the Memorial Day holiday weekend. We encourage all vehicle occupants to "Buckle Up".
For more information, visit:
The safety of our community does not have borders. It is the goal of every law enforcement agency to protect the citizens that we serve. Be the eyes and ears of your police department. When you see suspicious activity contact the Texas A&M University Police Department at 979-845-2345; the College Station Police Department at 979-764-3600; or the Bryan Police Department or the Brazos County Sheriff's Department at 979-361-3888. Together we can make a difference in our community. Hear It - See It - Report It
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Bright Ideas with Wilson at Walter G. Byers SchoolCHARLOTTE, N.C. - Wilson was at Walter G. Byers School where a group of fourth graders were getting "blinded by science" thanks to students from Myers Park High School and Bright Ideas. The learning initiative is a program that is part of the Bright Ideas education grant program. The Bright Ideas program is sponsored by the North Carolina Electric Co-operative to provide funds for N.C. teachers for innovative classroom projects that aren't normally funded. The program has helped the students at Walter G. Byers to improve their performance ratings Wilson talked with students from both schools as well as teachers, parents and Walter Byers' principle about the program. And, oh yeah, it was dress up day as well...a couple of interesting people showed up!
Bright Ideas Education Grant Program Follow Wilson on Twitter at: www.Twitter.com/WilsonShow
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The Most Winter Wonderful College Campuses
These pictures almost make you want to go to school. posted on
40. What campuses did we leave out? Add yours in the comments!
This post was created by a member of BuzzFeed Community, where anyone can post awesome lists and creations. Learn more or post your buzz!


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14 Jan Adobe's first Patch Tuesday of 2014 Roel 11 Dec Adobe Security Updates December 2013 - Fixing CVE-2013-5331 and more Roel 12 Sep Spam one step ahead of iPhone 5 release Maria 10 Apr Patch Tuesday April 2012 - Patching Multiple Web Based Client Side and Spearphishing Exposures Kurt Baumgartner 10 Feb When Certificate Authority Business Models and Vendor Certificate Policies Clash Kurt Baumgartner 07 Nov Gaddafi's death in spam Maria Join our blog You can contribute to our blog if you have +100 points. Comment on articles and blogposts, and other users will rate your comments. You receive points for positive ratings. |
This month's Adobe Patch Tuesday release sees fixes for Flash Player, Acrobat and Reader. All vulnerabilities get the highest priority rating. This means future exploits are likely.
This month Adobe's realing fixes for both Flash Player and Shockwave.
The vulnerabilies for Flash Player affect all platforms and concern two CVEs - CVE-2013-5331 and CVE-2013-5332, which both allow for remote code execution. Eploitation of CVE-2013-5331 using Microsoft Word as a leverage mechanism has been observed in the wild. Though Flash 11.6 introduced Click-to-Play for Office, users may still be socially engineered into running Flash content in Office documents. Make sure to apply this patch promptly.
Apple fans are eagerly awaiting the arrival of iPhone 5 which is due out today. Each unveiling of an iDevice is accompanied by a global buzz of excitement which usually attracts the attention of spammers: every new iPad or iPhone inevitably becomes the bait in numerous fake lotteries and other fraudulent emails.
However, customers are not only interested in Apple's devices but also their accessories. This year's first registered mass mailing dedicated to the new iPhone came from a Chinese company that has decided to fill this niche.
The advertiser, having first apologized for any inconvenience that may be caused by the email, offers users the chance to buy a case for the new iPhone 5 which has not even been officially presented.
Considering the sort of promises that usually appear in spam, one can only wonder why the sender didn't offer an actual iPhone 5 or, better still, an iPhone 6 (or whatever it'll be called in 2013? iPhone 5v?).
This month's patch Tuesday fixes a small set of critical vulnerabilities in a variety of client side software and one "important" server side Forefront UAG data leakage/information disclosure issue. Six bulletins have been created to address eleven exploitable flaws. Three of the six bulletins are top priority and should be addressed ASAP. These are the MS12-023 bulletin, patching a set of five Internet Explorer vulnerabilities leading to remote code execution, and the MS12-027 bulletin, patching the MSCOMCTL ActiveX Control currently receiving some attention as a part of very limited targeted attacks. If they must prioritize deployment, administrators should start their work here. Most folks should have automatic updates enabled and will silently receive the patches, or they can simply navigate their start menu and manually begin the Windows update process.
RCE attacks abusing these six IE and ActiveX vulnerabilities would look like web browser redirections to malicious sites hosting web pages attacking Internet Explorer and emails carrying malicious attachments constructed to appear familiar to the targeted victim. These are currently significant vectors of attack for both consumer/home and corporate Microsoft product users.
Microsoft also is recommending that administrators prioritize the Authenticode flaw and rated it critical, which could be used as a part of targeted attacks. And ActiveX controls can be delivered leveraging this vulnerability, so some distribution vectors may become enhanced. But this flaw allows for additions and modifications to existing code that in turn won't invalidate the existing signature.
A vulnerability exists in the .Net framework, allowing for XBAP applications to be run from the Internet Zone with a prompt. But anytime a decision like that is left to a user, it seems that we have a 50/50 chance of successful exploitation. The remaining vulnerabilty in the Office converter is significant and may result in RCE, but is much less likely to be attacked.
Dangerous, but manageable.
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A very important "internet trust" discussion is underway that has been hidden behind closed doors for years and in part, still is. While the Comodo , Diginotar, and Verisign Certificate Authority breaches forced discussion and action into the open, this time, this "dissolution of trust" discussion trigger seems to have been volunteered by Trustwave's policy clarification, and followup discussions on Mozilla's bugzilla tracking and mozilla.dev.security.policy .
The issue at hand is the willful issuance of subordinate CAs from trusted roots for 'managing encrypted traffic', used for MitM eavesdropping, or wiretapping, of SSL/TLS encrypted communications. In other words, individuals attempting to communicate over twitter, gmail, facebook, their banking website, and other sensitive sites with their browser may have their secure communications unknowingly sniffed - even their browser or applications are fooled. An active marketplace of hardware devices has been developed and built up around tapping these communications. In certain lawful situations, this may be argued as legitimate, as with certain known DLP solutions within corporations. But even then, there are other ways for corporate organizations to implement DLP. Why even have CA's if their trust is so easily co-opted? And the arbitrary issuance of these certificates without proper oversight or auditing in light of browser (and other software implemented in many servers and on desktops, like NSS ) vendor policies is at the heart of the matter. Should browser, OS and server software vendors continue to extend trust to these Certificate Authorities when the CA's activities conflict with the software vendors' CA policies?
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"Nigerian" spammers are extremely quick to react to the world's hottest news stories. News of the death of former Libyan leader Muammar Gaddafi had barely even broken before a string of emails from the "relatives of the deceased" began to appear.
Gaddafi's inconsolable relatives would be amazed if they knew how many emails had been sent in their name to Internet users around the world.
Instead of joining in the funeral rites, it looks like Gaddaffi's sons and daughters, or his wife, his brothers or even friends, have rushed straight to their PCs to write to people all over the world asking for help in spiriting uncountable millions of dollars out of the country.
According to the "Nigerians", the family of the Libyan leader is worth hundreds of millions of dollars. The emails which fell into my hands cited a minimum figure of $300 million.
Most of these emails purport to come from "Gaddafi's wife". The spammers seem to think their heart-rending stories about her hard life in her husband's family could explain her sudden desire to share his money with her close friends. Or even with distant strangers, depending on the recipient of the email.
She's not alone, though: an unlikely coalition of "opposition forces", "lawyers" and "bank clerks who have access to Gaddafi's accounts" also share the general desire to transfer the Colonel's money abroad.
"Nigerian" spam is, of course, pure fraud. None of Gaddafi's wives or even his lawyers will ever send emails to someone they do not know asking for help in getting millions of dollars out of the country and offering an unknown agent the commission for doing so. If a user takes the bait the fraudsters will extort money from him to allegedly cover different "expenses" until no more money is left. One should be realistic about the many offers received via the Internet from an unverified source calling himself Colonel Gaddafi's son (ALL OF A SUDDEN!).
Below are the screenshots of several "Nigerian letters" sent on behalf of Gaddafi's family:
The BBC today reported the announcement of the first UK 'mobile wallet', allowing people to pay for things using their mobile phone.
It sounds very convenient. I use my mobile phone for so many other things these days - why not as an alternative to cash? And on the face of it, isn't this just an extension of the same concept behind the Oyster Card? For those not familiar with the Oyster Card, it's an alternative to buying tickets to travel across London. You use a card instead: you put credit on the card at your convenience and the cost of the trip is debited automatically when you travel.
There's a key difference of course. If I lose my Oyster Card my loss is limited to the credit I've put on the card. The consequences could be far more serious if it's my smartphone, since someone could get access to my entire online identity. If my phone is my wallet too, it becomes even more of a target - to real-world criminals as well as cybercriminals.
We know from experience that convenience typically wins out over security. Keep watching.
Microsoft is making changes to its exploitability index to help clarify vulnerability issues in its software to its customers, keeping its program far ahead of other major vendors. Still, no system is perfect.
Microsoft's Security Response Center team has a steep uphill climb to conquer the mountain of vulnerability handling in their software that slowly but surely are publicly discovered, exploited and discussed. It is not an enviable task.
In just five days, the team will roll out a couple of changes. One change splits exploitability ratings for their newest product versions from all older releases. The two updates for the upcoming Patch Tuesday will also provide information for the bugs even if they do not provide remote code execution, and instead provide a surface for denial of service attacks.
Related Links
Ever since Stuxnet hit the news last year, there has been an increased interest in the area of industrial control systems (ICS). This has been evidenced by the fact that we've seen a recent surge in public releases of zero-day (unpatched) vulnerabilities and exploits.
Earlier this week, we saw no less than 34 unpatched vulnerabilities posted to Bugtraq. In the original article by The Register, there's also mention of a SCADA exploit pack which is currently for sale to pen-testers.
As long-time blog readers may know, I shifted my focus to North American threats some three years ago. Ever since, I've noticed major cultural differences in how security issues get tackled.
One way in which the difference is very clear is the use of secret questions as an added security measure. While secret questions are not overly common in Europe, they're very popular in the USA.
It goes without saying that out-of-band authentication used by many European banks is a much more secure approach than asking a secret qeustion next to a regular password. And banks are just one of many examples. Secret questions are everywhere now.
Enter the Facebook era. Rarely do I encounter a secret question that people wouldn't likely have posted the answer to on Facebook. It's worse with the services that allow users to reset their password based on answering the secret question(s) correctly.


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Carry your portable PC with impeccable style. This premium notebook carry case is designed by Italian brand NAVA and made from genuine premium Italian leather. It's versatile, too, thanks to a removable computer holder, dual interior spaces and an outer pocket. What's more, it fits note PCs up to the Samsung Series 9 15" notebook, so you can use it to carry a range of portable computers.
Practically the best way to travel
Features and specifications are subject to change without prior notification.


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A lot of posts of forum admins looking for their e-peen enlargement going "we have a lot posts of this". Who is with me?
If you have a problem with moderation then please PM Sunshine, not spam the forum with more useless shit threads.
Originally Posted by TradewindNQ Funny story, my last gf was a lot younger than me, she kept calling me a pedophile. I was like "lol that's a big word for a 6 year old." Originally Posted by docterfreeze I used to play the game, then everything became the same. Which is when I got a little... Nauuuughtyyyyy.
What Pebrocks said (but nicer). Please contact Sunshine regarding any issues with moderation.
SUCH INFRACTIONS MANY POST SO POWERFUL WOW (Armory) | (Twitter) Global Moderator of MMO-Champion.com


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In the interests of research I have walked on many battlefields that once were liquid with pulped mens bodies and spangled with exploded shells and splayed bone. All of them have been green again by the time I got there. Each has inspired a few good quotes in its day. Sad marble angels brood like hens over the grassy nests where nothing hatches.
Margaret Eleanor Atwood
It is a good rule never to see or talk to the man whose words have wrung your heart, or helped it, just as it is wise not to look down too closely at the luminous glow which sometimes shines on your path on a summer night, if you would not see the ugly worm below.
Rebecca H. Davis


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Bobcat of Lansing3237 W Miller RoadLansing MI 48911Phone: (517) 394-1155Toll Free: (877) 897-1832
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Pre-cut stir-fry vegetables make it easy to get your 5 to 10. Serve over rice or Asian noodles.
Spicy Pork Stir fry
Seared Mahi Mahi Salad with Tangerine, Guava and Pink Peppercorn Dressing
Mahi mahi is a relatively low-in-fat fish, but is still a source of healthy omega-3 fatty acids. Mild and sweet, it does not taste "fishy", making it a good pick for people who don't like fish much but want to get some into their diets. In the summer, grill the fish; mahi mahi is meaty and firm making it a good grilling fish.
Burrito Casserole
This hearty, family-pleasing meal is a Tex-Mex lover's delight. Use 1-3/4 cups (425 mL) of whatever PC salsa you have on hand; you could also add 1 can of drained corn in with the beans.
Layered Salad to Go
Cheer up your lunch time routine with this colourful and nutritious salad. Make on Sunday night and chill for three ready-to-go lunches.


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How does marijuana use affect school, work, and social life?
Research has shown that marijuana's negative effects on attention, memory, and learning can last for days or weeks after the acute effects of the drug wear off.15 Consequently, someone who smokes marijuana daily may be functioning at a reduced intellectual level most or all of the time. Not surprisingly, evidence suggests that, compared with their nonsmoking peers, students who smoke marijuana tend to get lower grades and are more likely to drop out of high school.16 A meta-analysis of 48 relevant studies—one of the most thorough performed to date—found cannabis use to be associated consistently with reduced educational attainment (e.g., grades and chances of graduating).17 However, a causal relationship is not yet proven between cannabis use by young people and psychosocial harm.
That said, marijuana users themselves report poor outcomes on a variety of life satisfaction and achievement measures. One study compared current and former long-term heavy users of marijuana with a control group who reported smoking cannabis at least once in their lives but not more than 50 times. Despite similar education and income backgrounds, significant differences were found in educational attainment: fewer of the heavy users of cannabis completed college, and more had yearly household incomes of less than $30,000. When asked how marijuana affected their cognitive abilities, career achievements, social lives, and physical and mental health, the majority of heavy cannabis users reported the drug's negative effects on all of these measures. In addition, several studies have linked workers' marijuana smoking with increased absences, tardiness, accidents, workers' compensation claims, and job turnover. For example, a study among postal workers found that employees who tested positive for marijuana on a pre-employment urine drug test had 55 percent more industrial accidents, 85 percent more injuries, and a 75-percent increase in absenteeism compared with those who tested negative for marijuana use.
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Watch It TODAY
On DVD
Watch Online
Latest On Grown Ups
Adam Sandler's 2010 movie,Grown Ups,about childhood friends/team mates reuniting after the death of their basketball coach,has been getting alot of crappy reviews lately.I am not quite sure why.I LOVED it.Granted,I'm normally the person who likes the movies that normal people think suck.But,I did not think that this movie would get bad feed back.At least not as much as it has got. I'm a fan of
David Spade is ******* hilarious. Sandler was mellow the entire movie, but I guess that's just his way. A feel-good comedy, one of my favorites.
Horrible movie, too many rude references to women and their bodies. I couldn't bear to watch the whole movie. Adam Sandler can only make so many movies come on now.
this movie mans movie
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Fifty years of great writing: Sports illustrated, 1954-2004Bringing together a lineup of writing talent worthy of the Hall of Fame, this anthology of classic stories represents the best work of sports writers over the past 50 years, including contributions from A.J. Liebling, Jimmy Breslin, George Plimpton, Wallace Stegner, William Faulkner, and John Steinbeck. |
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Review: Sports Illustrated: Fifty Years of Great Writing: 50th Anniversary 1954-2004
Nutzerbericht - GoodreadsFocused mostly on stories about players, especially Dick Butkus and Larry Bird, both of which were amazing. Not one selection written by a woman. And includes pieces by Steinbeck, Faulkner, and too much Roy Blount Jr.
Review: Sports Illustrated: Fifty Years of Great Writing: 50th Anniversary 1954-2004
Nutzerbericht - Ronald Wise - GoodreadsI enjoyed this book far more than I would have ever anticipated. Expecting to read a collection of articles about over-glorified jocks, I instead found a series of human dramas, most with a sad ending ... Vollständige Rezension lesen
Introduction by terry mcdonell | 6 |
The Players | 9 |
The Boxer and the Blonde by Frank deford | 10 |
Urheberrecht | |
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asked athletes ball baseball basketball Becker Berra Bill Bill Russell Billy Billy Conn Bird boxer boxing Brian Spencer called Carnoustie champion championship club clubhouse coach Conn Cosell course Cubs Dodgers drive eyes fans father feel fight fighter football friends golf Greenfield Jimmy hand Harry head heavyweight Heinz hole horse Howard Cosell Jack Nicklaus Johnny Podres Josh Josh Gibson Kalenjin Kenyan Kibor kids knew Larry Bird league linebacker Liston lived look Louis manager Mel Allen Muirfield Murray Nandi never night Park Peter Rono pitch play players Prestwick race Richie Rossovich runners Russell says Secretariat shot Stillman story talk teammates tell thing told took Troon Turnberry turned Tyson Veeck walked watch week Yankees Yogi YOGI BERRA York


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Definition of diuretic in English:
Line breaks: di|ur¦et¦icPronunciation: /ˌdʌɪjʊ(ə)ˈrɛtɪk
- (Chiefly of drugs) causing increased passing of urine.More example sentences
- It may be necessary to increase the diuretic dosage, decrease the beta-blocker dosage or discontinue the beta blocker.
- You have to be brave, silly or very determined to go out shopping shortly after you've taken your daily dose of diuretic pills.
- It supports natural diuretic action, but does not force water from the body like diuretic pills.
Back to top- A diuretic drug.More example sentences
- ACE inhibitors may be a preferred second drug to add to diuretics if necessary to achieve blood pressure control.
- Patients with atrial fibrillation also had more drug days for diuretics and for electrolytes.
- The mean blood pressure readings were the same for the diuretics and the newer drugs.
late Middle English: from Old French diuretique, or via late Latin from Greek diourētikos, from diourein 'urinate', from dia 'through' + ouron 'urine'.


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A simple approach to skin care makes sense in the summer, but there are also special challenges. You surely already know that you should wear sun protection daily to avoid premature aging and skin cancer, but you might not recognize the more immediate problems caused by heat and humidity. If your skin is dry, it may look and feel better in the warmer months. But if it's oily, the heat and humidity of summer can make it feel more so.
Small adjustments in the products you use can mean the difference between good skin and problem skin. For example, if your skin tends to be oily, start with a soap-free cleanser and finish with a few swipes of an alcohol-free toner, suggests Jeanine Downie, M.D., director of Image Dermatology in Montclair, New Jersey. "You'll remove makeup and dirt, but you won't strip the skin of all oils or cause irritation," she says. Exfoliation, important in warmer weather when you're revealing more skin, can easily be overdone, so proceed with caution. "Exfoliating scrubs, sea sponges and loofahs are great for elbows, knees and heels, but keep them away from the face," says Downie. Using scrubs on the face can produce microtears in the skin that can lead to uneven pigmentation if you're exposed to the sun. A much better approach is to use a cleanser and/or moisturizer with an alpha-hydroxy acid, such as glycolic acid or lactic acid. These exfoliate, improving the skin's tone and texture. If you normally use moisturizer every day, you may find that your skin will benefit from a lighter, oil-free formulation in the summer. Most oil-free moisturizers contain silicone or glycerin-based ingredients that provide moisture without feeling heavy or clogging pores. To lighten up, consider using a dual-purpose product like an SPF moisturizer. If you don't need a moisturizer, you could use a foundation with an SPF. If you like wearing foundation but would prefer lighter coverage, consider a tinted moisturizer. From the June 2002 issue of O, The Oprah Magazine
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Population-Genetic Properties of Differentiated Human Copy-Number Polymorphisms The American Journal of Human Genetics, Volume 88, Issue 3, 11 March 2011, Pages 317-332 Catarina D. Campbell, Nick Sampas, Anya Tsalenko, Peter H. Sudmant, Jeffrey M. Kidd, Maika Malig, Tiffany H. Vu, Laura Vives, Peter Tsang, Laurakay Bruhn and Evan E. Eichler Abstract Copy-number variants (CNVs) can reach appreciable frequencies in the human population, and recent discoveries have shown that several of these copy-number polymorphisms (CNPs) are associated with human diseases, including lupus, psoriasis, Crohn disease, and obesity. Despite new advances, significant biases remain in terms of CNP discovery and genotyping. We developed a method based on single-channel intensity data and benchmarked against copy numbers determined from sequencing read depth to successfully obtain CNP genotypes for 1495 CNPs from 487 human DNA samples of diverse ethnic backgrounds. This microarray contained CNPs in segmental duplication-rich regions and insertions of sequences not represented in the reference genome assembly or on standard SNP microarray platforms. We observe that CNPs in segmental duplications are more likely to be population differentiated than CNPs in unique regions (p = 0.015) and that biallelic CNPs show greater stratification when compared to frequency-matched SNPs (p = 0.0026). Although biallelic CNPs show a strong correlation of copy number with flanking SNP genotypes, the majority of multicopy CNPs do not (40% with r > 0.8). We selected a subset of CNPs for further characterization in 1876 additional samples from 62 populations; this revealed striking population-differentiated structural variants in genes of clinical significance such as OCLN, a tight junction protein involved in hepatitis C viral entry. Our microarray design allows these variants to be rapidly tested for disease association and our results suggest that CNPs (especially those that cannot be imputed from SNP genotypes) might have contributed disproportionately to human diversity and selection. Abstract | Full Text | PDF (1331 kb) |
Linkage Disequilibrium and Heritability of Copy-Number Polymorphisms within Duplicated Regions of the Human Genome The American Journal of Human Genetics, Volume 79, Issue 2, 1 August 2006, Pages 275-290 Devin P. Locke, Andrew J. Sharp, Steven A. McCarroll, Sean D. McGrath, Tera L. Newman, Ze Cheng, Stuart Schwartz, Donna G. Albertson, Daniel Pinkel, David M. Altshuler and Evan E. Eichler Abstract Studies of copy-number variation and linkage disequilibrium (LD) have typically excluded complex regions of the genome that are rich in duplications and prone to rearrangement. In an attempt to assess the heritability and LD of copy-number polymorphisms (CNPs) in duplication-rich regions of the genome, we profiled copy-number variation in 130 putative "rearrangement hotspot regions" among 269 individuals of European, Yoruba, Chinese, and Japanese ancestry analyzed by the International HapMap Consortium. Eighty-four hotspot regions, corresponding to 257 bacterial artificial chromosome (BAC) probes, showed evidence of copy-number differences. Despite a predisposing genetic architecture, no polymorphism was ever observed in the remaining 46 "rearrangement hotspots," and we suggest these represent excellent candidate sites for pathogenic rearrangements. We used a combination of BAC-based and high-density customized oligonucleotide arrays to resolve the molecular basis of structural rearrangements. For common variants (frequency >10%), we observed a distinct bias against copy-number losses, suggesting that deletions are subject to purifying selection. Heritability estimates did not differ significantly from 1.0 among the majority (30 of 34) of loci analyzed, consistent with normal Mendelian inheritance. Some of the CNPs in duplication-rich regions showed strong LD with nearby single-nucleotide polymorphisms (SNPs) and were observed to segregate on ancestral SNP haplotypes. However, LD with the best available SNP markers was weaker than has been reported for deletion polymorphisms in less complex regions of the genome. These observations may be accounted for by a low density of SNP data in duplicated regions, challenges in mapping and typing the CNPs, and the possibility that CNPs in these regions have rearranged on multiple haplotype backgrounds. Our results underscore the need for complete maps of genetic variation in duplication-rich regions of the genome. Abstract | Full Text | PDF (569 kb) |
Discovery and Statistical Genotyping of Copy-Number Variation from Whole-Exome Sequencing Depth The American Journal of Human Genetics, Volume 91, Issue 4, 5 October 2012, Pages 597-607 Menachem Fromer, Jennifer L. Moran, Kimberly Chambert, Eric Banks, Sarah E. Bergen, Douglas M. Ruderfer, Robert E. Handsaker, Steven A. McCarroll, Michael C. O'Donovan, Michael J. Owen, George Kirov, Patrick F. Sullivan, Christina M. Hultman, Pamela Sklar and Shaun M. Purcell Abstract Sequencing of gene-coding regions (the exome) is increasingly used for studying human disease, for which copy-number variants (CNVs) are a critical genetic component. However, detecting copy number from exome sequencing is challenging because of the noncontiguous nature of the captured exons. This is compounded by the complex relationship between read depth and copy number; this results from biases in targeted genomic hybridization, sequence factors such as GC content, and batching of samples during collection and sequencing. We present a statistical tool (exome hidden Markov model [XHMM]) that uses principal-component analysis (PCA) to normalize exome read depth and a hidden Markov model (HMM) to discover exon-resolution CNV and genotype variation across samples. We evaluate performance on 90 schizophrenia trios and 1,017 case-control samples. XHMM detects a median of two rare (<1%) CNVs per individual (one deletion and one duplication) and has 79% sensitivity to similarly rare CNVs overlapping three or more exons discovered with microarrays. With sensitivity similar to state-of-the-art methods, XHMM achieves higher specificity by assigning quality metrics to the CNV calls to filter out bad ones, as well as to statistically genotype the discovered CNV in all individuals, yielding a trio call set with Mendelian-inheritance properties highly consistent with expectation. We also show that XHMM breakpoint quality scores enable researchers to explicitly search for novel classes of structural variation. For example, we apply XHMM to extract those CNVs that are highly likely to disrupt (delete or duplicate) only a portion of a gene. Abstract | Full Text | PDF (698 kb) |
Copyright © 2010 The American Society of Human Genetics All rights reserved.
The American Journal of Human Genetics, Volume 86, Issue 6, 918-928, 27 May 2010
Yoji Kukita1, 5, Koji Yahara6, Tomoko Tahira1, Koichiro Higasa1, 7, Miki Sonoda2, Ken Yamamoto2, Kiyoko Kato3, 4, Norio Wake4 and Kenshi Hayashi1, ,
1 Division of Genome Analysis, Research Center for Genetic Information, Kyushu University, Fukuoka 812-8582, Japan
2 Division of Molecular Population Genetics, Kyushu University, Fukuoka 812-8582, Japan
3 Division of Molecular and Cell Therapeutics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan
4 Department of Gynecology and Obstetrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
5 Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan
6 Division of Life Science System, Fujitsu Kyushu Systems Inc., Fukuoka 814-8589, Japan
The majority of complete hydatidiform moles (CHMs) harbor duplicated haploid genomes that originate from sperm. This makes CHMs more advantageous than conventional diploid cells for determining haplotypes of SNPs and copy-number variations (CNVs), because all of the genetic variants in a CHM genome are homozygous. Here we report SNP and CNV haplotype structures determined by analysis of 100 CHMs from Japanese subjects via high-density DNA arrays. The obtained haplotype map should be useful as a reference for the haplotype structure of Asian populations. We resolved common CNV regions (merged CNV segments across the examined samples) into CNV events (clusters of CNV segments) on the basis of mutual overlap and found that the haplotype backgrounds of different CNV events within the same CNV region were predominantly similar, perhaps because of inherent structural instability.