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Don DraperPlayed by Jon Hamm
Don Draper wallowed in newlywed bliss with his beautiful, young second wife, Megan. Believing he had found his ideal partner, Don ignored his business and focused his time and attention on her, only to have his ego shattered when Megan rejected advertising as her career path. After this betrayal, Don refocused on the company, pursuing cornerstone client Jaguar motorcars, bonding with Joan on a drunken escape from the office and ultimately clashing with his partners over their decision to offer up Joan's virtue in exchange for winning the account. Don's anger and resentment came to a head when he discovered Lane Pryce embezzling money and fired him from the firm. Then, shaken by Lane's subsequent suicide, Don forgave Megan for leaving the agency and secured her an acting job on client Butler Shoe's commercial. The end of the season left Don in a bar, approached by a prospective paramour, pondering the question, "Are you alone?"
Read the Ad Age interview with Don Draper »
View Don Draper's three-year contract for Sterling Cooper from Season 3 »
Video: Don Draper for Season 4 »
Don Draper Quotes
"Advertising is based on happiness. We make the lie, we invent want."Season 1, Episode 1: "Smoke Gets in Your Eyes"
"I'm living like there's no tomorrow, because there isn't one."Season 1, Episode 1: "Smoke Gets in Your Eyes"
"It wasn't a lie, it was ineptitude with insufficient cover."Season 1, Episode 3: "Marriage of Figaro"
"Mourning is just extended self-pity."Season 1, Episode 6: "Babylon"
"I hate to break it to you but there is no big lie. There is no system. The universe is indifferent."Season 1, Episode 7: "The Hobo Code"
"The day you sign a client is the day you start losing them.'"Season 1, Episode 10: "Long Weekend"
"Just think about it deeply, then forget it…then an idea will jump up in your face."Season 1, Episode 11: "Indian Summer"
"You don't cover for me. You manage people's expectations."Season 2, Episode 3: "The Benefactor"
"Get out of here and move forward. This never happened. It will shock you how much it never happened."Season 2, Episode 5: "The New Girl"
"You want to be on vacation Pete? Because I can make that happen."Season 2, Episode 11: "The Jet Set"
"There will be fat years and there will be lean years, but it is going to rain."Season 3, Episode 1: "Out of Town"
"If you don't like what's being said, change the conversation."Season 3, Episode 2: "Love Among the Ruins"
"Change isn't good or bad. It just is."Season 3, Episode 2: "Love Among the Ruins"
"Maybe I'm late because I was spending time with my family reading the Bible."Season 3, Episode 7: "Seven Twenty Three"
"Believe me, Henry, everybody thinks this is temporary."Season 4, Episode 1: "Public Relations"
"I don't hate Christmas, I just hate this Christmas."Season 4, Episode 2: "Christmas Comes But Once a Year"
"Why does everybody need to talk about everything?"Season 4, Episode 5: "The Chrysanthemum and the Sword"
"Peggy, I'm glad this is an environment where you feel free to fail."Season 4, Episode 7: "The Suitcase"
"Ida was a hellcat?… Cooper lost his balls?… Roger's writing a book?"Season 4, Episode 7: "The Suitcase"
"I should've finished high school. Everything could've been different."Season 4, Episode 8: "The Summer Man"
"You want some respect? Go out and get it for yourself."Season 4, Episode 8: "The Summer Man"
"People tell you who they are, but we ignore it because we want them to be who we want them to be."Season 4, Episode 8: "The Summer Man"
"We're flawed because we want so much more. We're ruined because we get these things and wish for what we had."Season 4, Episode 8: "The Summer Man"
"I would have my secretary do it, but she's dead."Season 4, Episode 9: "The Beautiful Girls"
"We're gonna sit at our desks typing while the walls fall down around us. Because we're the least important, most important thing there is."Season 4, Episode 12: "Blowing Smoke"


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Camping World is nearby and their staff recommended we stay here for an early morning repair appointment. The registration building is far from the campground and there isn't enough space for a large rig to turn around there. There were only a handful of folks camping here, but the clerk assigned us to the same space he assigned another rig to. We asked for a site between #1 - 10 to be a bit farther from the noisy expressway, but he said all those sites were reserved. There were 4 rigs camped there. No one else came in. He gave us a password for a non-existent internet. This spot is over priced compared to similar casino campgrounds we've enjoyed. But it is close to camping world.
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When we phoned ahead to make sure that the camp sites were available, we were told to choose a site and that someone would be around later to collect the fee. There were two other rigs there, but no one stopped by. The park is centrally located and made a good over night stop on our way home. Electricity, water and sewer hook ups were conveniently located and worked well. The sites are very closely spaced. No restrooms or showers were in the vicinity.
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The owners have worked so hard to make this park attractive, they have forgotten that people being there can cause disorder. I felt like I was in a library and the librarian was constantly saying "Shush." We had a mechanical problem with our motor home and were aided by the repairman the owners recommended and they scolded him for opening the engine compartment. They enforced the rules like the Gestapo the entire week we were there and made us feel unwelcome. The 10mph speed limit was rigorously enforced. We camp six months a year and have never encountered such a lack of understanding from campground owners. They acted like we were the Beverly Hillbillies defiling their campground with our malfunctioning rig. Too bad - it was a nice park otherwise.


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AUSTIN, Texas -- Last year, after Bruce Springsteen gave a South By Southwest keynote speech for the ages, I remember pitying whoever had the unenviable task of following that. But it turned out I needn't have worried. For 2013, the SXSW braintrust put the keynote into the capable hands of Dave Grohl.
The Nirvana drummer and Foo Fighters main man is a decent songwriter, an incredible drummer and by most accounts a thoroughly decent chap. And like Springsteen, he's also a music fan who has never forgotten what it's like to be outside looking in -- and to want something so bad it drives you almost insane. Grohl got the brass ring with Nirvana, and it is to his immense credit that he understands and appreciates just what a charmed career he has had.
After some preliminary music by Black Violin (a pretty amazing young group combining jumped-up rock and flowing beats with violin and cello -- wow), Grohl ambled out to greet the crowd, donning reading glasses as he fretted that he hoped he "still looked like a rock star." That set the tone for an entertaining and self-effacing spiel in which Grohl traced his career from his early Road-to-Damascus experience via the 1973 Edgar Winter instrumental hit "Frankenstein" -- which Grohl performed a capella, Bobby McFerrin-style, quite capably. He also told some tales about his old punk-rock days, evoking the joy of the do-it-yourself life: "There was no right and there was no wrong because it was all mine."
That was an inspiring thought to carry outside into the beautiful Austin sunshine. Thursday was the kind of bucolic spring day that suckers people into moving here, which they regret once the scorching heat of August kicks in. But Thursday was perfect weather for finding a good spot to sit outdoors and listen to music.
Emphasis there on "sit," as in don't move around unless you have to. South By Southwest has become almost unmanageably huge nowadays, drawing throngs of people numbering in the tens of thousands, many of them credential-less kids on spring break. It's just about impossible to scurry around and see everything you'd want to -- or anything at all, sometimes. Pretty much the entire city was gridlocked Wednesday night, and I had a frustrating evening in which I spent a lot more time standing in lines that weren't moving than actually seeing bands.
Thursday had to be better, and it was. Following Grohl's keynote, I staked out a comfortable outdoor spot at the Threadgill's beer garden and took in some old favorites including John Hiatt, a cat who has truly turned into the cool old blues troubadour he always wanted to be; Buddy Miller and Jim Lauderdale, two fine journeyman enjoying late-career surges (among Miller's recent production credits is the Grammy-nominated "Leaving Eden" by Triangle stringband Carolina Chocolate Drops); and Richard Thompson, who never ceases to astonish. Thompson played magical guitar that somehow evoked everything from bagpipes on a misty morn' to divebombing Stukas.
Later on indoors, I caught another old favorite, Austin's own True Believers. SXSW has gotten so huge that every available space gets turned into a music venue, including some that shouldn't. The Believers played in a bike shop owned by Lance Armstrong, an odd and acoustically atrocious venue made even odder by all the pictures of the disgraced bike-racing icon on the walls. Nevertheless, the Believers just flat blew the roof off the joint with a blast of '80s glam-punk that has aged supremely well. It was the first time I'd seen them since...1994. I am delighted to report that they've not lost a step.
Another post-sundown highlight was Hiss Golden Messenger, working handle of Chapel Hill's M.C. Taylor, who played solo acoustic in a downtown Austin church and joked that he just doesn't play anything more uptempo than an amble. But his lyrical sentiments are just lacerating ("Heaven is the cruelest of 'em all" being just one"), sung in a plainspoken and quiet voice over exquisite acoustic guitar. It's difficult to describe what it is that makes him so affecting. He just is. There's a new album coming and it's great. More later.
This weekend will bring lots more March madness, including some possible opportunities to see a few big-name party-crashers who were announced at the last minute: Prince, Green Day and Justin Timberlake. The marketing goes on. But there's more magic in SXSW's smaller moments, like Hiss Golden Messenger playing for a few dozen attentive folks in a church.


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Office of the Registrar
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Description: | Supervised work at a newspaper, magazine,broadcast station, or public relations, marketingor advertising agency or department, or otherapproved media outlet. Arranged through thedepartment by individual students. Letter grades.May be taken multiple times up to a cumulative 4credits.Prerequisite: consent of instructor.1-4 credits (EL) |
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Posted: Wed Jan 30th, 2013 01:23 pm |
ddeanjohnson Member
Through luck, I purchased as a batch a man's library of dozens of volumes on Civil War history, some rather old, some autographed. Included are a number of biographies of or autobiographies by various Confederate generals. I plan to offer these old books individually on ebay in due course (I am "douglas1951" and have 100 percent positive feedback on ebay), but first I thought I'd try offering the list on a few forums, such as this, where people have a special interest in these subjects. If you'd like to receive by email a PDF file that contains the entire list of titles, with descriptions of condition and asking price, please send me an e-mail at ddeanjohnson // at / gmail, dot, com I don't have photos of every volume, but I can take photos of any volume in which a correspondent has a serious interest. |


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Before heading to Orlando and spring training next week, Atlanta Braves hitting coach Greg Walker was honored in his hometown of Douglas Monday.
The big news on "Greg Walker Day" was the city naming the athletic complex at Coffee Middle School in honor of Greg Walker.
Walker joined the Braves last season after working for eight years a hitting coach with the Chicago White Sox.
He also played nine seasons for the White Sox and Orioles.
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"I can't get extended," Smith said. "They didn't give me the money; I had to go get it. That's something I have to play it out and see how it goes from there."
AJC"I don't want to pre-judge on what the recommendation is going to be," [Commissioner David] Stern said. "But as a fan, he obviously bumped him. And you know what happens with respect to that...we have a hard and fast rule. Unless somebody trips you and sends you into him, nobody touches a referee. That's the proposition."
McMillan and Crawford had several conversations, and according to McMillan, none of them centered around the Blazers and the desire to win. Crawford instead wondered about himself: How much would he play, how many shots, what style of play? When McMillan told him he would have to play defense, Crawford blanched.
From Jason Quick's excellent recap of Nate McMillan's last season with the Portland TrailblazersAlso remember that Drew played Tracy McGrady 22 minutes the very next game after he publicly complained about his playing time and 15 minutes in the game after that. McGrady's subsequent reduced role was about his declining production and withdrawn demeanor, not his gripes. McGrady has been noticeably more engaged lately and, what do you know, he's getting more time (and playing better).
AJC Hawks beat writer Michael CunninghamJosh Smith on Mike Woodson's return: "He may not say it but he definitely wants this win, in this arena." #Hawks
Quote via Michael Cunningham"You can ask my coach right now. You can ask [GM] Rick [Sund]. I've never asked those guys to trade me. Never. I understand that trades are part of this league and part of this business. If Rick and LD think there is something that can better suit the Atlanta Hawks and I'm involved in that package, I completely understand that. But I've never walked in there and asked those guys to trade me. I've never said that. To see what people wrote about me and said about me, man. The thing that hurts the most is no one even called and asked me. No one asked me 'Did you say that?' You are the first person to ask me."
Marvin Williams denial of trade requestHaa.some of these writers kill me, 8 diff tweets about our "gaurd" play.every1 can tell u how 2 do it that's never done it!!! (Cont)
Jamal Crawford's twitter account after Wedneday's loss to Golden StateQuote To Note: (What is strange about this quote?) —"I don't think nobody out there is trying to quit. They just made good plays. We don't have (any) quitters on this team. " —Jeff Teague, on what went wrong against the 76ers
yahoo sportsI don't think there will be a sign-and-trade with Chicago for Jamal. The Hawks aren't looking to take on the kind of salary the matching rules require and the Bulls are focused on using their MLE to sign a free agent.
via Michael CunninghamMarvin Williams on back surgery: "I feel ten times better to be able to run and jump and be pain free." #Hawks
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The first rainy nights of early spring produce an amazing phenomenon that inspires awe in my students every year. It is the first time they witness the great salamander migrations of south central New York. Many of these amphibians are mole salamanders in the Ambystomatidae family, which are characterized by stout bodies and round heads.1 They spend most of the time underground, and, after having survived a harsh winter, they emerge by the thousands and make a beeline for breeding pools. They tend to be locally rare and, depending on their geographical location, may be classified as a species of concern, threatened, or endangered.2
Though details of mating behavior differ between species, they tend to choose breeding pools that are free of fish, and males perform complex mating rituals to attract females. A male grasps her, usually behind the forearms, and undulates his tale while producing chemical signals from the cloaca that may be important in sex recognition and distinguishing each other as a species. Afterward, he deposits a spermatophore on the bottom of the pool. Since males do not have the genitalia needed to deposit sperm into a female, they produce a spermatophore which consists of a gelatinous "bag" topped with a sperm cap containing seminal fluid. If the female is interested, she will use her cloaca to pinch off the sperm cap and incorporate the sperm so that internal fertilization can take place. She deposits a jelly-like egg mass onto underwater vegetation, and both will leave the pool to return to their subterranean burrows until next spring.
The Jefferson Complex of Salamanders
Complicating their reproductive life histories is the existence of a large number of females called unisexuals. Male unisexuals exist but they are rare and probably infertile.3 Unisexuals are thought to be products of past hybridization with other salamanders in the family4 and can be found in breeding pools from the Great Lakes region to the deciduous forests of Eastern North America. Individuals have uneven mixtures of genes from multiple salamander species and, until recently, four species were thought to be involved: the Jefferson (J) (Ambystoma jeffersonianum), blue spotted (L) (A. laterale), small mouth (T) (A. texanum), and tiger salamanders (Ti) (A. tigrinum). A fifth species, the stream-side salamander (A. barbouri), has been included with the others and are collectively called the Jefferson complex of salamanders.
Normally adult salamanders have diploid (2n = 28) body cells where one set of chromosomes (n = 14) comes from mom and the other (n = 14) comes from dad. Interestingly, the unisexuals of the Jefferson complex can be diploid hybrids or polyploid. Polyploidy is a rare and often lethal condition in animals. It occurs when more then two sets of chromosomes become incorporated into cells. Researchers have identified triploid (3n), tetraploid (4n), and pentaploid (5n) salamanders in this complex. Triploids are fairly common in any given population while tetraploids and pentaploids are found in much lower frequency.1 At first these creatures were formally named, but because the genetic story is far more complex, they are currently identified based on their genetic composition (see Table 1). Triploids have intermediate morphologies, are mostly female, and have larger eggs, cells, and cell nuclei, but deposit smaller clutch sizes than the purebred species.1 They are difficult to recognize in the field and are best identified genetically by analyzing chromosome numbers, microsatellite DNA, mitochondrial DNA (mtDNA), and allozymes (variant forms of the same enzyme). Recent research has produced a non-invasive means to rapidly distinguish between unisexual and bisexual individuals using a small tissue sample and analyzing the cytochrome b region of mtDNA.5
Over the years, researchers have hypothesized that unisexuals were products of various forms of reproduction that include parthenogenesis, hybridogenesis, gynogenesis, and unique forms of sexual reproduction.6 Parthenogenesis is a form of animal asexual reproduction where eggs develop without sperm and offspring are produced from unfertilized eggs.
Hybridogenesis is an unusually rare type of reproduction, is not completely asexual, and may have been identified in some frogs.7 For example, if hybridogenesis was happening, a Jefferson salamander (J) may hybridize with a blue-spotted salamander (L) and produce hybrid offspring (JL). As adults, the hybrids could backcross with purebred Jefferson males. During the larval stage of the new offspring, the Jefferson male genome is not incorporated, leaving the original (JL) female genetics intact for the next generation. In effect, the donor father's sperm is taken but discarded early in larval development.
Gynogenesis occurs when a sperm from a diploid male stimulates a triploid female egg to develop, but never gets incorporated into the new zygote. Triploids (3n), and on rare occasions tetraploids (4n) and pentaploids (5n), are produced through ploidy elevation.
Sexual reproduction can produce elevated ploidy levels. Sperm may contribute their chromosomes into unreduced 2n eggs, 3n eggs or 4n eggs and produce offspring of a higher ploidy level. Therefore, diploid females (2n) may produce triploid offspring, triploid females (3n) may produce tetraploid (4n) offspring, and tetraploid females (4n) may produce pentaploid offspring (5n).
Origins of the Jefferson Complex
Two evolutionary hypotheses have been put forth to explain the Jefferson complex and the various modes of reproduction that may have taken place.1 One hypothesis is that millions of years ago there was a small number of hybridization events followed by diploid hybrids backcrossing with purebreds and producing unisexual polyploids (JJL, JLL). Gynogenesis then ensues from generation to generation.
The second possibility of unisexual origins is the hypothesis that they have arisen on multiple occasions rather than one or a small number of times. Continued gene exchange between unisexuals and diploids continued at low rates. Evidence given for this hypothesis was that diploid (JL) and triploid (JJL and JLL) salamanders can arise from the same egg masses.
Because of the surprising genetic uniformity in unisexual species, except for A. texanum, many researchers tended to favor the first hypothesis because the above suggests that the complex was produced by a small number of events rather than at high rates on multiple occasions.8
The Mystery Deepens
Current data suggest that unisexual Ambystoma are not parthenogenetic because if they were, repeating nucleotide sequences of a few base pairs, called microsatellite DNA, should be the same among individual salamanders and they are not. Microsatellite DNA is used to determine kinship between individuals. In one study only 2/26 of the unisexual egg masses and 2/30 of unisexual adults had the same genetic sequences.6
There is also no evidence that hybridogenesis is taking place because it has not been demonstrated that a common genome is being transmitted from one generation to the next. Furthermore, what seems to tie the complex together genetically is a fifth species known as the stream-side salamander (A. barbouri). MtDNA sequence data is quite uniform in unisexuals and suggests they descended from a common maternal ancestor of A. barbouri that diverged 3-4 mya, according to "molecular clock" calculations.6 Historically this salamander was considered conspecific with the small-mouth salamander (A. texanum - T). Their populations don't tend to overlap, but sometimes they do, and hybridization has been documented. The stream-side differs from the small-mouth in breeding habitat, mode of egg deposition, egg size, clutch size, larval morphology, larval behavior, and teeth, and for these reasons are considered separate species.9
What, then, is going on? Recent analysis of allozymes and microsatellite DNA suggest that unisexual females are "stealing" male sperm from syntopic species (differing species in the same place at the same time) and incorporating the male genomes into their diploid/polyploid nuclei. In other words, these salamanders may be participating in a strange form of reproduction known as kleptogenesis, which may be unique in the animal world. Apparently these female kleptogens have a flexible enough chemistry to incorporate several different species of male sperm. Gynogenesis and/or ploidy elevation may further the process to produce nuclear genomic hybrids. This explanation seems to explain the data well, including unisexual uniformity of unrelated mtDNA sequences matching A. barbouri.
The Jefferson Complex with a Creation Perspective
The Jefferson Complex of salamanders is a great example of the difficulty with defining a species precisely. Though the general concept of species as a recognizable organism is useful in biosystematics and fieldwork, historically it has been arbitrarily defined, and a consensus definition is wanting. One definition often cited is a taxonomic group that can interbreed, but there are many others. The Jefferson complex of salamanders complicates how a species might be defined.
Baraminology is a creationist method of biosystematics where the goal is to define real groups of organisms based on the created "kinds" of Genesis 1.10 Creationist researchers have begun to analyze the Ambystomatidae family. Using statistical analysis and documenting the ability of hybridization in bisexuals, preliminary results have classified them as a monobaramin.11 A monobaramin is defined as the group of known organisms that share biologically meaningful similarity with one other.12 Except for the time element, and from a young earth creation perspective, past hybridization events and kleptogenesis are not inconsistent hypotheses for the origins of Jefferson complex unisexuals.
However, if we take the underlying differences between an evolutionist and creationist to a deeper level, it is not the science that is being argued, but the worldviews of the researchers. If we can differentiate the evolutionary worldview from the biblical worldview we can examine assumptions at a deeper level.
The evolutionary interpretation tells of an ancestral female stream-side salamander diverging 3-4 million years ago. This interpretation often assumes several things. First, it assumes that deep time has happened and that millions and billions of years have passed since the random origin of first life. Second, it assumes the idea of neutral evolution where it is believed that the majority of DNA is junk and without function.13 As more data are revealed, the concept of non-functional DNA is becoming harder to demonstrate. Third, this assumes that a "molecular clock" exists. The 3-4 million year divergence is based on the molecular clock hypothesis which assumes that we can determine the mutation rate in mtDNA. This hypothesis, in turn, assumes that neutral evolution is true and the majority of DNA is without function. However, these concepts make numerous other assumptions which have all been contradicted in the evolutionary literature.14, 15 Even many evolutionists are questioning the notion that a molecular clock exists.
In contrast, biblical creationists recognize the Bible as the Word of the Creator and have a different set of assumptions. The Bible clearly reveals that life was deliberately created and designed by God thousands of years ago. Destruction was brought upon the planet by a great Flood 4500 years ago. Land vertebrate air breathers observed today are assumed to have diversified from the originals brought aboard the ark. Mole salamanders, being terrestrial in the adult form, could have been easily cared for. As Christians who believe God and His Word, we assume God has created His creatures to persist. In a fallen world these creatures are predicted to have the genetic machinery to respond to changing environments and have all sorts of ingenious methods for accomplishing what the Creator has given them to do. This understanding suggests that the Ambystomatidae family probably started from at least a single pair, since the flood, no more than 4500 years ago.
There is still much to learn about the Jefferson salamander complex. Just how they diversified and the non-random, programmed mechanisms capable of responding to changing environments are still mysteries, but they continue to inspire exciting venues for creationist research. These salamanders are an amazing testament to the power and creativity of our Creator and Savior Jesus Christ. Though my students may not recognize the true source of their awe as they beheld these creatures and helped them cross the road, my prayer is that one day they will meet and trust the One who was the basis of their awe, the Author of Life and Savior of their souls.
Help keep these daily articles coming. Support AiG.
- Petranka, J.W. 1998. Salamanders of the United States and Canada. (Washington D.C.: Smithsonian Institution Press), pp. 122–129. Back (1) Back (2) Back (3) Back (4)
- Julian, S.E., King, T.L. and Savage, W.K. Novel jefferson salamander, Ambystoma jeffersonianum, microsatellite dna markers detect population structure and hybrid complexes. Molecular Ecology Notes 3:95–97. Back
- Bogart, J.P., Klemens, M.W. 2008. Additional distributional records of Ambystoma laterale, A. jeffersonianum (amphibia: caudate) and their unisexual kleptogens in northeastern North America. American Museum Novitates 3627:1–58. Back
- Gibbs, J., Breisch, A.R., Ducey, P.K., Johnson, G., Behler, J.L., Bothner, R.C. 2007. Amphibians and Reptiles of New York State: Identification, History, and Conservation. (New York: Oxford University Press) pp. 62–63. Back
- Noël, S., Dumoulin, J., Ouellet, T., Galois, P., and Lapointe, F-J. 2008. Rapid identification of salamanders from the Jefferson complex with taxon-specific primers. Copeia 1:158–161. Back
- Bogart, J.P., Bi, K., Fu, J., Noble, D.W.A., and Niedzwiecki, J. 2007. Unisexual salamanders (genus Ambystoma) present a new reproductive mode for eukaryotes. Genome 50:119–136. Back
- Beerli, P. 1995. Hybridogenesis in water frogs. http://www.tolweb.org/notes/?note_id=579 accessed 2 May 2010. Back
- Petranka, p. 123 Back
- Petranka, pp. 40–46. Back
- Wood, T. and Murray, M.J. 2003. Understanding the Pattern of Life (Nashville, TN: Broadman & Holman Pub.), p. 3. Back
- Brophy T., and Kramer, P.A. 2007. Preliminary results from baraminological analysis of the mole salamanders (Caudata: Ambystomatidae). Occasional Papers of the BSG 10:10–11. Back
- Wood, T.C., Wise, K,. Sanders, R., and Doran, N. 2003. A Refined Baramin Concept. Occasional Papers of the BSG 3:1–14. Back
- Carter, R. 2009. The slow, painful death of junk dna. http://creation.com/junk-dna-slow-death accessed 6 May 2010. Back
- Carter, R. 2009. The neanderthal mitochondrial genome does not support evolution. Journal of Creation 23(1):40–43. http://creation.com/images/pdfs/tj/j23_1/j23_1_40-43.pdf accessed 6 May 2010. Back
- Carter, R. 2007. Mitochondrial diversity within modern human populations. Nucleic Acids Research 35(9):3039–3045. http://nar.oxfordjournals.org/cgi/reprint/35/9/3039 accessed 6 May 2010. Back


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Dallas ~ Fort Worth ~ Plano ~ Allen Grapevine ~ Garland ~ Flower Mound Rockwall ~ Sunnyvale www.urologyclinics.com
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Urology Clinics of North Texas uses the most advanced robotic-assisted technology. This new technology provides a more precise, and less invasive surgery for prostate cancer. This typically reduces the size of the incisions needed, shortens the hospital stay and speeds patient recovery with better outcomes.
Urology Clinics of North Texas is accredited by the American College of Radiology (ACR). American College of Radiology (ACR) accreditation is a peer-reviewed, educationally focused evaluation process to help assure patients of the highest level of image quality and safety.
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Oakwood Corporate Housing offers furnished apartments with amenities often including concierge, swimming pool, fitness center, and business center. Oakwood Corporate Housing can handle everything for your temporary stay with just one call. Our service is available virtually anywhere in North America whether you need an apartment, townhouse or single family home. We provide everything from furniture to electronics. We can even arrange maid service and ensure that utilities and cable service are ready to use before you move in. Oakwood owns and operates the company that supplies the furnishings and housewares to all our corporate residences, so you can be assured of the availability and quality of these necessities. Paying for our service is easy too. Rent, utilities, and all services are included on one simple statement. Credit cards accepted. Oakwood offers much more - for less cost. Our accommodations are much larger than suite hotel rooms. You will enjoy spacious living rooms, kitchens and dining areas. You would probably expect to pay more for all these comforts. The truth is, Oakwood usually costs significantly less than a hotel. Plus, a complete kitchen and on-site laundry facilities means you will save money during your stay. All Oakwood Corporate Housing guests are provided with a fully equipped kitchen, so that you can make coffee in the morning or a full dinner after work. Linens, plants and many other household items are also provided. Housekeeping service is offered on a weekly, bi-weekly or monthly basis. Oakwood has the people and systems that make locating and reserving corporate housing stress-free. Oakwood operates 100 sales offices across the United States to serve you. We are easily accessible and respond quickly to your needs. Across America, we employ 400 highly-trained account management and customer service professionals. And now - Oakwood has expanded internationally with locations in London, Bangkok, Manila, and Guangzhou.
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OmpT: Molecular Dynamics Simulations of an Outer Membrane Enzyme Biophysical Journal, Volume 87, Issue 5, 1 November 2004, Pages 2942-2953 Marc Baaden and Mark S.P. Sansom Abstract Five molecular dynamics simulations (total duration >25ns) have been performed on the Escherichia coli outer membrane protease OmpT embedded in a dimyristoylphosphatidylcholine lipid bilayer. Globally the protein is conformationally stable. Some degree of tilt of the β-barrel is observed relative to the bilayer plane. The greatest degree of conformational flexibility is seen in the extracellular loops. A complex network of fluctuating H-bonds is formed between the active site residues, such that the Asp210-His212 interaction is maintained throughout, whereas His212 and Asp83 are often bridged by a water molecule. This supports a catalytic mechanism whereby Asp83 and His212 bind a water molecule that attacks the peptide carbonyl. A configuration yielded by docking calculations of OmpT simulation snapshots and a model substrate peptide Ala-Arg-Arg-Ala was used as the starting point for an extended Hückel calculation on the docked peptide. These placed the lowest unoccupied molecular orbital mainly on the carbon atom of the central C=O in the scissile peptide bond, thus favoring attack on the central peptide by the water held by residues Asp83 and His212. The trajectories of water molecules reveal exchange of waters between the intracellular face of the membrane and the interior of the barrel but no exchange at the extracellular mouth. This suggests that the pore-like region in the center of OmpT may enable access of water to the active site from below. The simulations appear to reveal the presence of specific lipid interaction sites on the surface of the OmpT barrel. This reveals the ability of extended MD simulations to provide meaningful information on protein-lipid interactions. Abstract | Full Text | PDF (893 kb) |
An Active Site Water Network in the Plasminogen Activator Pla from Yersinia pestis Structure, Volume 18, Issue 7, 14 July 2010, Pages 809-818 Elif Eren, Megan Murphy, Jon Goguen and Bert van den Berg Summary The plasminogen activator Pla from Yersinia pestis is an outer membrane protease (omptin) that is important for the virulence of plague. Here, we present the high-resolution crystal structure of wild-type, enzymatically active Pla at 1.9 Å. The structure shows a water molecule located between active site residues D84 and H208, which likely corresponds to the nucleophilic water. A number of other water molecules are present in the active site, linking residues important for enzymatic activity. The R211 sidechain in loop L4 is close to the nucleophilic water and possibly involved in the stabilization of the oxyanion intermediate. Subtle conformational changes of H208 result from the binding of lipopolysaccharide to the outside of the barrel, explaining the unusual dependence of omptins on lipopolysaccharide for activity. The Pla structure suggests a model for the interaction with plasminogen substrate and provides a more detailed understanding of the catalytic mechanism of omptin proteases. Summary | Full Text | PDF (1332 kb) |
Size and Dynamics of the Vibrio cholerae Porins OmpU and OmpT Probed by Polymer Exclusion Biophysical Journal, Volume 98, Issue 9, 5 May 2010, Pages 1820-1829 Guillaume Duret and Anne H. Delcour Abstract The trimeric OmpU and OmpT porins form large, triple-barrel hydrophilic channels in the outer membrane of the pathogen Vibrio cholerae. They have distinct pore properties, such as conductance, block by deoxycholic acid, and sensitivity to acidic pH. Their three-dimensional structures are unknown, but they share significant sequence homologies. To gain insight into the molecular basis for the distinct functional properties of these two similar porins, we carried out polymer exclusion experiments using planar lipid bilayer and patch-clamp electrophysiology. By studying the partitioning of polyethylene glycols (PEGs) of different molecular weights into each porin, we determined an effective radius of 0.55 nm and 0.43 nm for OmpU and OmpT respectively, and found an increased OmpU effective radius at acidic pH. PEGs or high buffer ionic strength promotes the appearance of single step closures in OmpU similar to the acidic-pH induced closures we documented previously. In addition, these closing events can be triggered by nonpenetrating PEGs applied asymmetrically. We believe our results support a model whereby acidic pH, high ionic strength, or exposure to PEGs stabilizes a less conductive state that corresponds to the appearance of an additional resistive element on one side of the OmpU protein and common to the three monomers. Abstract | Full Text | PDF (642 kb) |
Copyright © 2008 The Biophysical Society All rights reserved.
Biophysical Journal, Volume 94, Issue 1, 71-78, 1 January 2008
Marilisa Neri*, Marc Baaden†, Vincenzo Carnevale*, Claudio Anselmi*, Amos Maritan‡ and Paolo Carloni*, ,
* International School for Advanced Studies and CNR National Institute for the Physics of Matter, National Simulation Center, Trieste, Italy
† Institut de Biologie Physico-Chimique, CNRS, Paris, France
‡ Dipartimento di fisica G. Galilei, Universita' degli studi di Padova, Padova, Italy
Conformational fluctuations of enzymes may play an important role for substrate recognition and/or catalysis, as it has been suggested in the case of the protease enzymatic superfamily. Unfortunately, theoretically addressing this issue is a problem of formidable complexity, as the number of the involved degrees of freedom is enormous: indeed, the biological function of a protein depends, in principle, on all its atoms and on the surrounding water molecules. Here we investigated a membrane protease enzyme, the OmpT from Escherichia coli, by a hybrid molecular mechanics/coarse-grained approach, in which the active site is treated with the GROMOS force field, whereas the protein scaffold is described with a Go-model. The method has been previously tested against results obtained with all-atom simulations. Our results show that the large-scale motions and fluctuations of the electric field in the microsecond timescale may impact on the biological function and suggest that OmpT employs the same catalytic strategy as aspartic proteases. Such a conclusion cannot be drawn within the 10- to 100-ns timescale typical of current molecular dynamics simulations. In addition, our studies provide a structural explanation for the drop in the catalytic activity of two known mutants (S99A and H212A), suggesting that the coarse-grained approach is a fast and reliable tool for providing structure/function relationships for both wild-type OmpT and mutants.


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Kaman agrees to deal with Mavericks
Posted: 9:08 PM Jul 11, 2012
Chris Kaman says he has agreed to a deal with the Dallas Mavericks.
The 7-foot center, who played in New Orleans last season, announced on his Twitter account Wednesday that he is going to Dallas to play with Dirk Nowitizki, his friend and teammate on the German national team during the 2008 Olympics.
The Mavericks didn't announce any deals Wednesday night.
In a later tweet, Kaman asked if there was a good lake to live on close to downtown Dallas.
Kaman averaged 13.1 points and 7.7 rebounds in 47 games with the Hornets last season. He played the first eight seasons of his career with the Los Angeles Clippers, and was an All-Star in 2010. But he was prone to injuries in the season before and after that.
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text: When G-d said to Noah, "The end of all flesh is come before Me," Noah said: "What will You do with me?" But he did not pray for the world, as Abraham would pray for the city of Sodom.. This is why the Flood is called "the waters of Noah" (Isaiah 54:9) -- he is culpable for them, because he did not appeal for mercy on the world's behalf.(Zohar)


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Above: 2012: The year climate change got real.
Some Western editorialists today are focused on national, or even global, issues.
Join the Discussion | |
Post a Comment |
Like climate change:
— The hottest year: Time to end climate change denial — Salt Lake Tribune Editorial
One degree Fahrenheit. That's all. That's the margin by which the average national temperature in the United States in 2012 broke the record for the highest ever recorded.
But before anyone dismisses the new record as being a small difference, remember that the normal variance for the nation's average temperature, year to year, is measured in tiny fractions of a degree. The range since the late 19th century has only ranged between 50 and 54.3 degrees. Until 2012, that is, when it reached a record 55.3 degrees.
So the one-degree difference is properly referred to as "shattering" the old mark, in the same sense that a difference of only half of a second could honestly be said to have shattered a previous best for, say, the 100-meter dash. ...
— Keeping an eye on the oilsands — Edmonton (Alberta) Journal Editorial
... There can't be many Albertans left out there still clinging to the illusion that the largest energy project in the world — one that has created 170 square kilometres of tailings ponds — is having no impact on our environment. ,,,
Gun violence:
— Stop these tools of mass murder - Denver Post Editorial
— Gun mania — Los Angeles Times Editorial
— Seize moment on gun rules — Eugene Register-Guard Editorial
— A targeted – not shotgun – approach to gun reforms — Tacoma News Tribune Editorial
Health care costs:
— Health care spending slows, but not insurance costs — St. Louis Post-Dispatch Editorial
— Health care cost controls must not be undermined — Spokane Spokesman-Review Editorial
National security:
— Why Obama stands firm on Chuck Hagel — San Francisco Chronicle Editorial
— Grunt-turned-statesman, Hagel is right choice for Pentagon — St. Louis Post-Dispatch Editorial
— Hagel is a sound choice — Eugene Register-Guard Editorial
Pick a defense secretary who has seen the face of war
— Confirm Obama's security team — Seattle Times Editorial


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Welcome to the Tri-County
oil & Gas Expo Website
New technologies now make it possible to produce vast quantities of natural gas from the Marcellus Shale formation that underlies most of Southwestern Pennsylvania. This development has created historic opportunity for the citizens of Fayette, Greene and Washington counties, as well as the broader region. All of us are anxious to participate in this giant economic wave. We face the prospects of new wealth, yet we also face the challenges of responsible production and sensible stewardship.
These "Gas Expos" are an attempt by concerned citizens in business, education and government to make sure that the activity generated by the Marcellus Shale play is handled in a responsible and effective manner. The key to this is great communication among all parties, and continuing education about crucial issues.
We also want our local suppliers of goods and services to grow their businesses, and for our local people to prosper and expand. We have earned a reputation as serious and reliable business people and a capable labor force. The Tri-County Oil & Gas Expo Committee is working to facilitate cooperation between industry leaders and our local leaders in government, education and commerce and to disseminate information to the public so our local people can participate in the development of this crucial energy resource for our nation. Through these efforts, we hope to ensure the maximum progress in the development of the quality of life in Southwestern Pennsylvania.
read moreHouse Democratic Policy Committee meeting on energy
Pennsylvania State Representative Pam Snyder is hosting a House Democratic Policy Committee meeting on energy. The Meeting will take place on Monday, September 16th at 2:00 PM at the Jefferson Volunteer Fire Department. This event is open to the public. For more information please contact her office at 724-966-8953.
Click the logo above to join the Marcellus on Main Street online business directory that has been designed to connect small businesses with the natural gas industry.


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What is your Achilles' heel? Is it when you see someone else and want what they have? Of course, we never really have the full picture -- we just see what's on the surface.
I'm reminded of a story by Dennis Prager in his book "Happiness is a Serious Problem." The author shares that he met a young man who struck him as "having it all" -- an exciting career, a fulfilling family life and a home in the city he loved.
When the subject of the Internet came up, the "ideal" man blessed its existence because he could look up information on multiple sclerosis, the terrible disease affecting his wife. Prager says he felt like a fool for assuming nothing unhappy existed in the man's life.
So, how do we shift our focus from what's missing? Here's a clue I've learned: Gratitude is the antidote to misery.
You could start by making a short list of five things for which you're grateful. Some days this may be tougher than others. (If you're doing this list at the end of the day, you can at least be thankful that the day is over!)
After practicing this short exercise for a while, you may very well find that you come up with more and more things to be grateful for. Over time, these will help to drown out the chorus of negativity brought on by what's missing -- or at least help to neutralize it.
Don't get me wrong. I'm not suggesting that we strive to live continuously by the platitudes of "stop and smell the roses" or "don't sweat the small stuff." It's the contrasts in life that create the depths of our experiences, help us to learn life lessons and weave the tapestries of the lives we lead.
We all go through life's ups and downs -- at times descending into dark nights of the soul. I'm just suggesting that there may be options to feel better eventually -- even when it looks like there's no way out.
Switching gears may take time, and you need to commend yourself for baby steps. Continuously beating yourself up in your mind for your alleged shortcomings can take a big toll on your health.
By the same token, holding resentment against someone else can be just as bad. There's a saying that holding resentment is like drinking poison and expecting someone else to get sick.
You're the only one who can decide how long you stay in any particular state -- days, weeks, months, years? Nobody else can know what you're going through. Nobody else is walking in your moccasins.
Linda Arnold, MBA, is a certified wellness instructor and chairwoman and CEO of The Arnold Agency, an advertising, public relations and government relations firm in Charleston. Reader inquiries may be directed to Linda Arnold, The Arnold Agency, 117 Summers St., Charleston, WV 25301, or e-mailed to livinglifefu...@arnoldagency.com.


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Umphrey's McGee
Umphrey's McGee or UM is an American progressive rock band originally from South Bend, Indiana, whose music is often referred to as "progressive improvisation", or "improg". Although the band is part of the jam band scene, like Phish and the Grateful Dead, they are much more influenced musically by progressive rock artists such as King Crimson, Yes, Pink Floyd, Dream Theater, Frank Zappa, and early Genesis, as well as heavy metal bands such as Iron Maiden. The band also identifies The Police, The Beatles, and Led Zeppelin as primary influences. UM experiments with many genres including funk, jazz, blues, metal, electronic, bluegrass, and folk.
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text: Korman Center Equipment and Software Equipment The Korman Computing Center is equipped with a B&W, color, and transparency printing station; Windows 7 and Mac OS machines; and several multimedia classrooms. Rooms are equipped with ceitrng-mounted overhead projectors, white boards, SMART boards, and videoconference equipment. The Korman Center Interactive Map provides each room's specific seating and equipment information. The Bring Your Own Laptop (BYOL) lounge has ethernet and power hookups available to the Drexel community. Software Requests Requests for special software installation in Korman classrooms must be made a month prior to the beginning of the term that you plan to use the room (i.e., submit your request in August for the Fall Term). We cannot make additions or changes to software on the computers once the term has started. Please be aware of trcensing issues which may prevent instaltrng software on multiple computers. Requests must be accompanied by original media and trcense documentation. Software Installed in Classrooms PC Software MAC Software Adobe Acrobat Pro 11 Adobe Dreamweaver CS6 Adobe Illustrator CS6 Adobe Flash Pro CS6 Adobe Photoshop Elements 10 ArcGIS 10.1 Autocad 2014 Hyperchem 8 Java SDK & JRE 7 Matlab 2013b Maple 17 Mozilla Firefox Microsoft Office 2010 Word Excel Powerpoint Publisher OneNote Access R for Windows Rexcel SSH Secure Shell SPSS Statistics 22 VLC Media player Visual Studio 2013 X-Win32 2010 Java SDK & JRE 7 SPSS Statistics 22 Matlab 2013b Maple17 Mozilla Firefox Microsoft Office 2011 Adobe Acrobat Pro 11 Adobe Dreamweaver CS6 Adobe Illustrator CS6 Adobe Flash Pro CS6 Adobe Photoshop Elements 10 Fetch Quicktime VLC Media player


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Description: Designed by Lila Tueller for Riley Blake Designs, this fabric is perfect for quilting, apparel and home décor accents. Colors include light and medium blue with white, yellow and lime.
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Description: Designed by Sheri McCulley Designs for Riley Blake, this cotton print fabric is perfect for quilting, craft projects, apparel and home decor accents. Colors include red, yellow, turquoise, white and aqua.


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Parov Stelar Tickets
Find the Parov Stelar tickets you're looking for on viagogo, the world's largest ticket marketplace. Select an event to view the range of tickets available or view the Parov Stelar tour on a map to find an event near you. You can also sell your spare Parov Stelar Concert Tickets on viagogo, and listing tickets is free. All Parov Stelar tickets are covered by the viagogo Ticket guarantee!
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Ottakringer Arena Wiesen, Wiesen AT Parov Stelar Band & The Cat Empire - Nova Jazz & Dance Night 2014 | Austria | €54.90 | ||
Tollwood Sommerfestival, Munich DE Parov Stelar Band - Tollwood Festival 2014 | Germany | €41.80 | ||
Zeltfestival Ruhr, bochum DE Parov Stelar Band - Zeltfestival Ruhr 2014 | Germany | €45.10 |
Parov Stelar Tour Dates and Tickets
Buy or sell your Parov Stelar tour tickets at viagogo. You can also sign up for Ticket Alerts above to stay informed about new and upcoming Parov Stelar 2014 tour dates. If you have any questions about using viagogo, visit our Frequently Asked Questions page.
viagogo is your online ticket marketplace for concert tickets, sports tickets and theatre tickets.


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US President Barack Obama praised a comedian Wednesday for organizing a "Rally to Restore Sanity," saying it may help instill more "courtesy" in American political life. The president, speaking in Richmond, Virginia, tacitly welcomed US comic Jon Stewart's plan for the rally, a thinly veiled dig at right-wing US icon…
By Gary Younge, The Guardian
Read MoreBy Joshua Holland, Moyers & Company
Read MoreBy Zoe Williams, The Guardian
Read MoreRaw Story is a progressive news site that focuses on stories often ignored in the mainstream media. While giving coverage to the big stories of the day, we also bring our readers' attention to policy, politics, legal and human rights stories that get ignored in an infotainment culture driven solely by pageviews.
Founded in 2004, Raw Story reaches 9 million unique readers per month and serves more than 30 million pageviews.
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Detroit Auto Show
7:02 am
Tue January 11, 2011
Stabenow 'excited' for Volt win
By Zoe Clark
Michigan Senator Debbie Stabenow visited the North American International Auto Show yesterday in Detroit. The Associated Press reports the Democrat said, "she's excited that the Chevrolet Volt was named Car of the Year," at the show. The Car of the Year award was announced yesterday morning. The Ford Explorer won the Truck of the Year award.
Former House Speaker and California Congresswoman Nancy Pelosi was scheduled to attend the show yesterday but canceled the trip after Saturday's shooting in Arizona.
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New symphony director brings a new excitement
Karen Warren, Staff
January 18, 2013 | Updated: January 20, 2013 10:10am
After years of playing in orchestras, Mark Hughes had learned to dread the beginning of Hector Berlioz's "Symphonie fantastique." Sitting with his trumpet awaiting his cue, he'd have to listen as the violins - entering with the first phrase of a long, slow, delicate melody - failed to come in together.To continue reading this story, you will need to be a digital subscriber to HoustonChronicle.com.
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270 results
Commentaries by Domizio Calderini on Works by Juvenal, Statius, Ovid, and Propertius
Under the influence of Italian humanism and of his book-collector tutor János Vitéz, the Archbishop of Esztergom, Matthias Corvinus of Hungary (1443–1490), developed a passion for books and learning. Elected king of Hungary in 1458 at the age of 14, Matthias won great acclaim for his battles against the Ottoman Turks and his patronage of learning and science. He created the Bibliotheca Corviniana, in its day one of Europe's finest libraries. After his death, and especially after the conquest of Buda by the Turks in 1541, the library ...
A Modern Depiction of Ireland, One of the British Isles
Abraham Ortelius (1527-98) was a Flemish engraver and businessman who traveled widely to pursue his commercial interests. In 1560 he became interested in scientific geography during a voyage with Gerardus Mercator. Ortelius's major work, Theatrum orbis terrarum (Theater of the world), was published in Antwerp in 1570, at the threshold of the golden age of Dutch cartography. Theatrum presented the world in its component parts and reflected an age of exploration, broadened commercial connections, and scientific inquiry. Now considered the world's first atlas, the original Theatrum was enhanced ...
Sangallo's Sienese Sketchbook
The so-called Sienese sketchbook of the famous architect and engineer Giuliano da Sangallo was originally in the library of Sienese scholar Giovanni Antonio Pecci. The librarian Giuseppe Ciaccheri, a committed and passionate collector who enriched the Biblioteca comunale degli Intronati di Siena with works of art of outstanding quality, acquired it in 1784. Together with the Codice Barberiniano in the Biblioteca Apostolica Vaticana, the sketchbook bears witness to the architect's prolific production of drawings and is a valuable source of knowledge about his work. The small format and the ...
This antiphonary (a book containing the choral parts of the Holy Office) was transferred to the Biblioteca comunale degli Intronati di Siena in 1811 from its place of origin, the Augustinian monastery of San Salvatore in Lecceto near Siena. By virtue of its specific liturgical function, the antiphonary, designed for the use of the monastic community, contains both the daytime and the nocturnal services. It was illuminated in 1442 as part of an extensive artistic program within the monastery promoted under priors Bartolomeo Tolomei and Girolamo Buonsignori. A bull by ...
Collection of Speeches and Latin Epistles by Renaissance Humanists
This manuscript, dating to the late-15th century, formerly belonged to the Sienese Alessandro Tegliacci, as stated in a note written on the initial page by an unknown later owner: "Dedit mihi Alex(ande)r Tegliaccius die(?) 8 decembris 1581 atque sua humanitate donavit" (Alessandro Tegliacci kindly gave this to me as a gift on December 8, 1581). The decoration on the same leaf bears the coat of arms of the Tegliacci family. Alessandro can perhaps be identified as the scholar who was called by Cosimo II to be professor of ...
Treatise of the World's Creation
This manuscript, which contains a Tractatus de creatione mundi (Treatise on the World's Creation) from the Book of Genesis followed by a narration of the Passion of Christ (folios 99r–128v), is one of the most significant examples of late-13th-century Sienese illumination. The pictures, partly watercolor drawings and partly proper illuminations, were made by an extremely sophisticated Sienese artist who was heavily influenced by Transalpine miniaturists and active from around 1290 through the next decade. The illustrations, sketched by a fast, concise hand, stand out for their strikingly smooth ...
Poem Concerning the Departure of the Magi
This 15th-century manuscript, in Renaissance script, contains a poetic composition (De profectione Magorum adorare Christum et de innocentibus interfectis ab Herode) by a "Gabriel Volaterranus." The author was in all likelihood Gabriello Zacchi da Volterra, the archpriest (acting dean, vicar to the bishop) of the cathedral, who was from a culturally sophisticated background and died in 1467 at the age of 33. The author dedicates the work to Tommaso del Testa Piccolomini, the secret assistant of Pope Pius II (folio 132r), to whom Pius had granted the privilege of kinship ...
Dialogues of the Gods
This manuscript contains ten of the dialogues of Lucianus, a second-century rhetorician and satirist who wrote in Greek, in the Latin version of Livio Guidolotto (also seen as Guidalotto or Guidalotti). Livio, a classical scholar from Urbino, was the apostolic assistant of Pope Leo X, and he dedicated his translation to the pope in an introductory epistle of 1518 ("Romae, Idibus maii MDXVIII"; folio 150v). The latest possible date for the manuscript thus is 1521, the year Leo died. The emblem of Giovanni de' Medici, with the beam accompanied by ...
The Seville Bible
Biblia hispalense (The Seville Bible), also known as the Toletanus Codex, is a manuscript from the first half of the tenth century, in Latin written in lower-case Visigothic script by at least four copyists. The titles also appear in Hebrew, and there are notes in Arabic in the margins. The manuscript consists of booklets of eight sheets each, on parchment, with the text in three columns of 63–65 lines. Included are the texts of the Old and New Testaments, with a preface, prologues, and commentaries by Saint Jerome, Saint ...
Beato of Liébana: The Codex of Fernando I and Doña Sancha
Around the year 776, a monk by the name of Beato or Beatus, possibly the abbot of the monastery of Santo Toribio de Liébana, wrote a work entitled Comentarios al Apocalipsis (Commentary on the apocalypse), which had an extraordinary success in the following five centuries. Thanks to his great erudition, Beato combined in this text, as a summa, many commentaries on the topic of the apocalypse by such authors as Saint Irenaeus of Lyon, Saint Gregory the Great, Saint Isidore of Seville, and the 4th-century scholar Ticonius. The genre of ...
Etymologiae (Etymology) is the best known work by Saint Isidore of Seville (circa 560–636), a scholar and theologian considered the last of the great Latin Church Fathers. It takes its name from a method of teaching that proceeds by explaining the origins and meaning of each word related to a topic. Saint Isidore drew on many different sources in his attempt to summarize all ancient knowledge and save it for posterity. The fame of the work led to it being widely copied and disseminated, and its popularity lasted even ...
On the Sphere and the Cylinder; On the Measurement of the Circle; On Conoids and Spheroids; On Spirals; On the Equilibrium of Planes; On the Quadrature of the Parabola; The Sand Reckoner
In the middle of the 15th century, a number of manuscripts by the third-century BC Greek mathematician Archimedes began to circulate in the humanistic centers in the courts of Italy. Piero della Francesca (circa 1416–92), the Renaissance artist best known for the frescos he painted for the Vatican and for the chapels in Arezzo, transcribed a copy of a Latin translation of Archimedes's geometry (a compilation of seven surviving treatises) and illustrated it with more than 200 drawings representing the mathematical theorems in the texts. This manuscript, long ...
Psalter of Frederick II
This remarkable illuminated psalter decorated in the Byzantine style was commissioned by the Holy Roman Emperor Frederick II of Sicily (1194–1250) for his third wife, Isabella of England (1214–41). Frederick married Isabella in 1235. By design and execution, the manuscript illuminations combine the color palette of Byzantium with the stylistic rendering of the plasticity of the human body common to the Italian school of the period. Probably executed at the scriptorium in Acri, a hill town in Calabria, the manuscript is decorated with a full-page initial letter encompassing ...
Book of the Passion of Saint Margaret the Virgin, with the Life of Saint Agnes, and Prayers to Jesus Christ and to the Virgin Mary
This volume is a compilation of three manuscripts produced in Bologna at the end of the 13th century. It begins with the Passion of Saint Margaret of Antioch, in Latin. This is followed by two texts in Italian, one describing the life and devotion of Saint Agnes and one containing prayers to the Virgin Mary. Each manuscript is written in a different hand; evidence suggests that the three parts were brought together and bound at the beginning of the 14th century. The only part of the book that is illustrated ...
Bucolics, Georgics, and the Aeneid
This 15th-century manuscript, known as the Riccardiana Virgil, includes the texts of the three extant works of the great Roman poet Virgil, the Bucolics, the Georgics, and the Aeneid, and contains 88 miniature paintings in the lower margin of many of the vellum leaves. The miniatures, 86 in the Aeneid and one each in the Bucolics and the Georgics, are attributed to Florentine artist Apollonio di Giovanni and his workshop. Those illustrating the story of Aeneas reflect the influence of Benozzo Gozzoli, who in 1459 completed a suite of frescos ...
Claudius Ptolemaeus (circa 100–circa 170), known as Ptolemy, was an astronomer, mathematician, and geographer of Greek descent who lived and worked in the Egyptian city of Alexandria. In his Geography, Ptolemy gathered all the geographic knowledge possessed by the Greco-Roman world. He used a system of grid lines to plot the latitude and longitude of some 8,000 places on a map that encompassed the known world at the height of the Roman Empire. Ptolemy's work was lost to Europe in the Middle Ages, but around 1300 Byzantine ...
The Encyclopedia of Medicaments
This book is a printed edition of the Pandectarum Medicinae (Encyclopedia of medicaments) by Matthaeus Sylvaticus (died circa 1342), consisting of an alphabetized list of medications (primarily of herbal origin). Sylvaticus relies on the work of Simon of Genoa (flourished end of 13th century), who provided a lexicon of Latin, Greek, and Arabic medical terms in his dictionary, Clavis Sanationis. Sylvaticus also draws upon works by Greco-Roman authorities such as Galen, Dioscorides, and Paulus Aegineta (seventh century). Among his other sources were the writings of important scientists from the Islamic ...
Muḥammad al-Farghānī's Elements of Chronology and Astronomy
This work is a Latin translation of al-Farghānī's influential and well-known Kitāb jawāmiʿ ʿilm al-nujūm wa uṣūl al-ḥarakāt al-samāwīya (Book of generalities of astronomy and bases of celestial motions). Aḥmad ibn Moḥammad ibn Kathīr al-Farghānī was an astronomer who flourished at the court of the early Abbasid caliphs. He appears to have been active in the court of al-Ma'mun. If he is the same figure who is said to have been entrusted by al-Mutawakkil with the construction of the nilometer in Cairo, then he would have been active ...
The Method of Medicine
This book is a compendium of medical works, printed in Basel in 1541 by the shop of Heinrich Petri (1508–79), also known by his Latinized name Henricus Petrus. It includes the Latin translation of the 30th chapter of the celebrated al-Taṣrīf li man 'ajiza al-ta'līf (The arrangement of [medical knowledge] for one who is unable to compile [a manual for himself]) by the important Andalusian physician Abū al-Qāsim ibn al-'Abbās al-Zahrawī. The book also contains a four-part work concerning the treatment of wounds and lesions by ...
Complete Book on the Judgment of the Stars
This book is a Latin translation of Ibn al-Rijāl Abū al-Ḥasan al-Shaybānī al-Maghribī al-Qayrawānī's principal scientific work, Kitāb al-bāriʻ fī aḥkām al-nujūm (Complete book on the judgment of the stars). Known in the Latin West as Haly Abenragel, or Haly Albohazen, Ibn al-Rijāl was the astrologer and leading official at the court of the Zīrid prince Muʻizz ibn Bādīs (1007 or 1008–62) at Qayrawān (present-day Kairouan, Tunisia). Kitāb al-bāriʻ consists of eight books covering several different types of astrology. These include interrogations, nativities, the discussions of the ...
Commentary on the Chapter Nine of the Book of Medicine Dedicated to Mansur
This work is a commentary in Latin by Italian professor and physician Giovanni Arcolani (died 1484, also known as Ioannis Arculani) on the ninth book of Kitāb al-ṭibb al-Manṣūrī (The book of medicine dedicated to Mansur) by the renowned Persian polymath Abū Bakr Muḥammad ibn Zakarīyā Rāzī (circa 865–circa 925). Known in the Latin West as Rhazes or Rasis, Rāzī was born in Rayy, just south of Tehran. He is generally considered one of the towering figures in medicine in the medieval period. His influence on ...


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Nice apartments 300 meters from the boat to/from Ibiza. The area is rich in rentals and nearby 2 markets but is not noisy. Playa de Ses Illetas (the best beach of Formentera) is 10 minutes far cycling. My room was big enough for a holiday, at second floor, with a wonderful view on the sea. I had also a kitchen... More
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You must earn 10,000 points to post other members' whiteboard
Congratulations on posting for 500 consecutive days, that's real commitment. .YB.Shep
Congratulations on having the dedication to post for 500 consecutive days. Keep up the Good Work. Warren 8-)
Congratulations on posting 400 consecutive days. Done in less then two years. Lets be buddies also. Thanks. Shep
Congrats on your up and coming 365-Consecutive-Days-of-posting! Nice:) I'm trying to catch up to you...no one between us in the Rochester standings are moving at all! Hope to catch up w/ you soon in the Roc Points Leaders!
Thanks for becoming my newest buddy. Hope that you have a great Memorial Day weekend. Your new buddy, Warren {:-D
Congratulations on having the energy to post for 300 consecutive days. Keep up the Great Work. Want to become buddies??? Warren {:-)


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DescriptionMaybe the best line on the wall, marred only by the fact that the crux is particularly desperate, which is why there is a chain draw for bailing off of if in the middle if you can't do the crux. Starts right of Peter's route and works up and right to a few crimpy and technical moves right to deposit you underneath the chain draw. At least 2 solutions to the crux exist. One very powerful, one very crimpy and still powerful. Climb to the top of the wall from here, work out right using the seam in the upper roof to clip anchors just above the "triangle". Protection8 bolts, one chain draw


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back to topProduct Description
A cute screen print graphic graces the front of this adorable Girl's Short Sleeve T-Shirt from Carhartt. Made of 4.4 oz., 100% cotton jersey. Crew neck t-shirt with back neck tape and whip stitched seams. Glitter Carhartt logo screen print with rhinestones and pink sugar glitter on front and C Fill screen print with pink sugar glitter on back. VPN: CA9166-U35.


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Incontinence (cont.) Medical Author:
Melissa Conrad Stöppler, MD, Chief Medical Editor
Melissa Conrad Stöppler, MD, Chief Medical EditorMelissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology. Medical Editor:
Charles Patrick Davis, MD, PhD
Charles Patrick Davis, MD, PhDDr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications. IN THIS ARTICLE
Urinary Incontinence Symptoms
Patient Comments
Stress Incontinence In stress incontinence, a variable amount of urine escapes suddenly with an increase in intra-abdominal pressure (for example, when the abdomen tenses). Not much urine is lost, unless the condition is severe. This type of urinary loss is predictable. People with stress incontinence do not usually have urinary frequency or urgency (a gradual or sudden compelling need to urinate) or need to wake up at night to go to the bathroom (nocturia). Urge Incontinence With urge incontinence, or overactive bladder, there is uncontrolled urine loss associated with a strong need to go to the bathroom. While the urge to urinate may be gradual, it is often sudden and rapid and occurs without any warning. Urge incontinence cannot be prevented. In this situation, the entire contents of the bladder are lost rather than a few drops of urine. People with overactive bladder feel the intense need to urinate but are unable to hold back the urine. Other symptoms include frequent urination, urgency, and nocturia. Some situations trigger urge incontinence, including turning a key in the door, washing dishes, or hearing running water. Urge incontinence also may be triggered by drinking too much water or drinking coffee, tea, or alcohol. Mixed Incontinence This type of incontinence includes the symptoms of stress incontinence and urge incontinence together. With mixed incontinence, the problem is that the bladder is overactive (the urge to urinate is strong and frequent) and the urethra may be underactive (the urine cannot be held back even without the urge to urinate). Those with mixed incontinence experience mild to moderate urine loss with physical activities (stress incontinence). At other times, they experience sudden urine loss without any warning (urge incontinence). Urinary frequency, urgency, and nocturia also occur. Most of the time, the symptoms blend together, and the first goal of treatment is to address the part of the symptom complex that is most distressing. Reflex Incontinence Urinary symptoms of reflex incontinence are the same as those of urge incontinence, but the symptoms of reflex incontinence occur in people with neurologic disorders. Most people with reflex incontinence experience symptoms of urinary frequency, urgency, and nocturia. In this situation, the bladder empties urine as it fills (like a reflex). Of all the types of urinary incontinence, reflex incontinence probably is the most difficult to treat; however, this condition may be treated with medications, neuromodulation (electrical stimulation of specific nerves to influence the nerve circuit that controls urination), bladder surgery, or chronic indwelling (left inside the bladder) bladder catheters. Overflow Incontinence In overflow incontinence, the urine overflows from the bladder because the pressure inside the bladder is higher than the urethral sphincter closure pressure. In this condition, there may be no strong urge to urinate, the bladder never empties, and small amounts of urine leak continuously. Overflow incontinence is prevalent in older men with an enlarged prostate and is less common in women. Because the bladder is too full, the bladder empties even though the bladder muscle may not contract. Overfilling of the bladder can occur if the outlet from the bladder is obstructed so urine backs up in the bladder or if the bladder muscle does not work so urine is not completely expelled from the bladder during urination. People with overflow incontinence may feel like the bladder does not empty completely, their urine flows out slowly, and/or that urine dribbles out after voiding. Symptoms of overflow incontinence may be similar to those of mixed incontinence. A small amount of urine may be lost when intra-abdominal pressure is increased. There may be symptoms of frequency and urgency as the detrusor muscle attempts to expel urine. Functional Incontinence People with functional incontinence have relatively normal bladder function and control. Other conditions separate from the bladder affect their ability to reach the toilet in time. Next Page: Must Read Articles Related to Incontinence
Bedwetting (nocturnal enuresis) is the involuntary passage of urine while sleeping. Causes of bedwetting include urinary tract infection, diabetes, emotional pr...learn more >>
Bladder Control Problems
Bladder control problems, or urinary incontinence, affect over 13 million people in the U.S. Causes include urinary tract infection, overactive bladder, blocked...learn more >>
Enlarged Prostate
A man's prostate gland usually starts to enlarge after he reaches age 40 years or middle age. This condition is called benign prostatic hyperplasia (BPH). The p...learn more >>
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Urinary incontinence is a medical condition that has significant negative effects on quality of life and may cause social stigma, financial hardship, and associated medical problems.


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or Connect
Manufacturer: Harvest Moon Farms 1 Results
Harvest Moon Farms Lavender Spray (perfect for baby bums!)
This is a CCOF certified organic Lavender hydrosol (steam distilled flower water) spray ...simple, pure, perfect for your baby's bum! Find your favorite, softest cloth to use as the wipe, and keep them in a container of lavender hydrosol. You can also add a few drops of essential oil to make it a stronger disinfectant cleanser that is super safe and healing for the skin. I'm a doula...


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Hellertown pharmacists charged in alleged online drug scheme
Updated On: Dec 01 2012 05:49:06 AM CST
Hellertown, Northampton Co. was shrouded in mystery earlier this week. Why was the Hellertown Pharmacy raided by the DEA, the FBI and the IRS?
The question became clear Friday. The pharmacy and two of its pharmacists were involved in an illegal internet prescription drug ring, according to court documents filed by the U.S. Attorney for the Southern District of New York.
The documents charge owner Peter J Riccio and his head pharmacist, Lena Lasher, with taking part in a scheme that allowed people to buy prescription pain medication without a legal prescription.
The two saw a financial windfall of $13 million between 2010 and 2012, federal authorities said.
Customers would visit one of five web sites and complete a medical history questionnaire with a series of yes and no questions, according to court documents. Website operators then reportedly electronically sent the form to a doctor, who without consulting or seeing the patient, would issue the prescription and send it back to the website operators.
The prescription would end up at one of three pharmacies owned by Riccio in Pennsylvania and New Jersey, according to the indictment.
Three out-of-state physicians and five website operators are part of the multi-count indictment. Charges include narcotics distribution, conspiracy, mail and wire fraud and money laundering.
69 News visited Lasher's modest home in Hunterdon Co., N.J. and Riccio's upscale residence in Somerset Co., N.J. Neighbors said federal authorities were there Thursday, lining the streets with police and undercover units.
"I guess you could say out of any movie, it was just like lines and lines. We didn't know if something happened to them, if there was some sort of medical injury," said Vicy Mendez.
If convicted, Lasher and Riccio each faces 88 years in prison and millions of dollars in fines.
The U.S. attorney's office said the investigation is ongoing.
Copyright 2012 WFMZ. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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