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Cytokine-Mediated Programmed Proliferation of Virus-Specific CD8+ Memory T Cells
Cytokine-Mediated Programmed Proliferation of Virus-Specific CD8+ Memory T Cells
Immunity, Volume 38, Issue 1,
Pages 131-139,
Publication Date 20 December 2012
Copyright © 2013 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.immuni.2012.09.019
Hans-Peter Raué
Carol Beadling
Jennifer Haun
Mark K. Slifka
Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
Division of Hematology & Oncology, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
Corresponding author
► CD8+ T cells undergo programmed proliferation after brief exposure to IL-12 and IL-18 ► Cytokine-induced programmed proliferation requires CD4+ T cell help ► Temporary exposure to inflammatory cytokines provides selective T cell advantage
During infection, CD8+ T cells not only respond to antigenic signals through their T cell receptor (TCR) but also incorporate inflammatory signals from cytokines produced in the local infected microenvironment. Transient TCR-mediated stimulation will result in programmed proliferation that continues despite removal of the antigenic stimulus, but it remains unclear whether brief exposure to specific cytokines will elicit similar effects. Here, we have demonstrated that brief stimulation of memory T cells with interleukin-12 (IL-12) and interleukin-18 (IL-18) results in tightly regulated programmed proliferation, in addition to acquisition of enhanced virus-specific cytokine production and cytolytic activity. CD8+ T cells briefly exposed to IL-12 and IL-18 in vitro showed improved antiviral activity in vivo, as demonstrated by increased proliferation and reduced viremia. These results indicate that even transitory exposure to inflammatory cytokines can provide a selective advantage to infiltrating CD8+ T cells by triggering a developmental program that is initiated prior to direct contact with virus-infected cells.


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This term applies to Champagne bottles only and is the equivalent of Jeroboam. It will hold 4.5 litres of wine which is equal to 6 standard sized bottles.
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Warm-Weather Clothing
For warm days, your running clothes should help wick away moisture, keep you cool and protect you from the sun's rays. Key features to shop for:
Lightweight fabrics: Moisture-wicking polyester is marketed under a variety of names (e.g., Nike DriFit, The North Face FlashDry, Polartec Power Dry). Each has proprietary performance tweaks to enhance performance. Many tops are augmented with cooling mesh panels for high-heat areas such as your back, underarms and sides.
Chafe-free seams: Look for flat or welded seams placed away from areas that could impede your stride or natural running motion.
Sun protection: Items with UPF ratings provide tested protection from the sun's UVA and UVB rays. The higher the number, the better the protection. See the REI Expert Advice article, Sun Protection Clothing Basics, for details.
Reflectivity: If you run at night or in the cool hours of dusk or dawn, you'll want gear with reflective accents to be better seen by drivers.
Pockets: These can unobtrusively hold your ID card, debit card and keys. Common on shorts, concealed pockets are sometimes offered on shirts as well.
Cool-Weather Clothing
When the temperature drops, look for insulated versions of the warm-weather choices noted above. Differences include:
- Insulating fabrics: Lightly insulated styles provide a bit more warmth with minimal weight. Some include water-repellent finishes or waterproof membranes to create all-in-one protection from cool, wet weather (versus wearing a separate rain shell).
- Thumbholes and mitts: Many long-sleeve tops offer thumbholes to increase hand coverage and warmth so you can possibly skip the need for gloves. They also help to keep sleeves in place as you run. A few styles even have mittens built in to the sleeves.
- For colder conditions, soft-shell jackets offer a combination of light insulation and breathability that works well for runners.
Running tights (many with windproof fronts are also good for cross-country skiing) provide light insulation and generous breathability in cold weather. Most feature a snug fit and stretchy fabric to allow unencumbered motion.
Cold-Weather Clothing
For seriously cold conditions, consider layering your clothing to keep your core body temperature consistent as you work out. Layering consists of 3 basic stages: an inner wicking layer, an insulating middle layer and a weatherproof outer layer. The key is to stay comfortable by peeling off layers as you heat up, and adding them when you slow down and cool off.
See the REI Expert Advice article, Layering Basics, for details.
Don't forget your head and extremities for overall comfort.
- Hats: Your exposed head responds to changes in temperature more quickly than any other part of your body. It's easy to carry along a fleece or wool hat for winter workouts to cover your head in cold weather. A breathable, lightweight hat can also help you stay cool in summer.
- Gloves: When it's cold out, your body tries to preserve heat within vital organs by decreasing the amount of blood pumped to your extremities. For cold-weather exercise, a pair of moisture-wicking, breathable gloves is advisable. For cool conditions, thin liner gloves may be all that you need.
- Socks: When you exercise heavily, your feet produce a lot of perspiration. In summer, this can lead to blisters unless you wear synthetic or merino wool socks that wick away moisture. In winter, this moisture can lead to cold feet. Avoid cotton socks for all but light workouts.


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Networking began in earnest Monday. The event is a series of seminars, new product displays and o
NES Group's Ralph Hanan and Alan Kessler
Haier's Shariff Kan and Richard Block
Verbatim's Becky Morrison
Eton's Samantha Nguyen and Shan Hassan
Lee Dodson of Premier Mounts
Whalen's Paul Jones with Thomas Freeman of BrandsMart USA
Vivitar's Jerry Cohen, and Stefan Betesh
SDI's Evan Stein and Saul Ashkenazi
PanDigital's Eric Larsen
Scosche's Kas Alves
Midland's Charlie Speights
Toshiba's Maria Repole
Devon Mish of M-Edge
Jasco's Steve Trice
iWave's Jack Scaba and Steven Scaba
From left: Michael Stiefel of DAS with iLuv's Jim Schwartz, Dena Kim and Howard Kim
Networking began in earnest Monday. The event is a series of seminars, new product displays and o |
A quick look at Nationwide's Primetime! event in Las Vegas in August. A quick look at |
Photos from the Aug. 20 edition of TWICE Photos from the Aug. 20 edition of TWICE |
PRO Group is here at CEDIA Expo to meet with suppliers, see a host of new upscale products and di |
A who's who of sports stars, politicians and entertainment luminaries attended the 7th annual |
Just a lazy Tuesday afternoon at Shea Stadium with my Nikon P80.
Photos from the July 2 issue of TWICE. Photos from the July 2 issue of TWICE. |
The legendary rock band Aerosmith was in New York City's Times Square last week to help launc |
Photos from the Oct. 8 edition of TWICE Photos from the Oct. 8 edition of TWICE |
The Photo Marketing Association show opened in Las Vegas on March 3. The Photo Marketing A |
Spring Retailvision held this year in Nashville culminated with the show's award ceremony |
Some of the unique sights at this year's Nationwide Marketing Group PrimeTime! |
Head Monster Noel Lee, Ludacris and others from the company's CES press event.
The Anti-Defamation League's (ADL) national consumer technology industry group |
Home Theater Specialists of America (HTSA) welcomed its dealers and vendors to CEDIA Expo with a |
The Samsung charity event brought in more than $1 million. The Samsung charity event broug |
Faces in the crowd at the CEA's Washington Forum, held this week.
CE execs, Congressmen and policy advisers and makers CEA's annual Washington Forum to discuss |


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There isn't some clear-cut formula for making a great game, but Epic hasn't ignored bullet-point features in expanding the Unreal Tournament series, which is now in its third installment. The multiplayer-focused first-person shooter series started off in 1999 with great graphics, crisp control, solid networking (which led to smooth online gameplay), and hectic action. These basics haven't been neglected, even as expectations have changed--and have significantly increased--over the last five years. However, UT has never been just about settling for the basics, and to this end, the new Unreal Tournament 2004 has a tremendous variety of maps and modes of play. In the same package, you'll find cutthroat deathmatching as good as it's ever been, plus large team-based modes in the style that's become so popular lately. Simply put, this is the multiplayer action game that offers something for everyone--even those who prefer playing offline, since the UT bots are better than ever and are still the best in the business.
Unreal Tournament 2004 is an impressive game in every respect.
Anyone who bought or considered buying Unreal Tournament 2003 will wonder what's new and improved in this latest game. Epic didn't take UT 2003's tepid response lying down, so not only did it work to make the inclusion of vehicles and new modes a success but also went back and added in some classic elements from the original UT. In this everything-plus-the-kitchen-sink approach, the classic sniper rifle coexists with UT 2003's lightning gun--or rather, it replaces it in some maps. Also returning is an improved version of the objective-based assault mode that was popular in the original UT but was taken away in the sequel. You've even got the original UT announcer's voice, who is just one of five announcers now included. Before we go into the truly new features in detail, it's worth noting that Atari has included a $10-off rebate coupon for owners of UT 2003, thus bringing the new stand-alone game to the price point of an expansion pack at $29.99.
While there's a whopping total of 10 different game modes, assault and onslaught are bound to get the most attention. The new onslaught mode is the biggest departure from past UT games, and it sets up team battles for 10 to 32 players on large outdoor maps. At first glance, the expansive, rolling terrain might look a lot like Tribes 2 or Halo, and like these games, there are maps big enough to make running from point-to-point seem prohibitively slow. But a few key innovations keep the pace fast, and as powerful as the vehicles are, those on foot are far from helpless. Onslaught focuses on power nodes that are strategically distributed on the maps, and the ultimate goal of the mode consists of destroying the power core located in the opposing base. The nodes connect in certain configurations, and nodes located behind front lines can't be attacked, which concentrates the action around just a node or two at a time. Once a node linking to the power core is captured, the core itself can be attacked directly, thus pressuring the defenders to desperately man the base defenses or recapture the pivotal node.
Oftentimes, the tide of battle will swing in one side's favor, but in the ensuing tug-of-war, things can drag out to the time limit. This sends the game to sudden death, with both cores draining based on the number of nodes each team controls. Other maps lend themselves to more volatile battles, with the cores being connected and attacked in parallel. In every case, it's easy to understand which team is leading and what you have to do to win. Unlike the abstract system of a game like Battlefield 1942, onslaught's scoring system is concrete, and a glance at the power core health meters and the minimap reveals how a match's momentum is swinging.
Skillful use of the new vehicles is one way to turn the battle, but for the most part, they don't overwhelm the battlefield. Even the goliath tank, which can take out most anything with one hit from the main gun, can be taken out by a high-flying raptor fighter, turrets located at most nodes, or even a few hits from the rocket launcher. In the meantime, the swift ground vehicles--like the manta hovercraft, scorpion buggy, and hellbender heavy truck--are all lots of fun to drive, thanks to a top-notch physics system. Pulling off stunts rewards you with a special message detailing your achievement, and running enemies over, while plenty satisfying, isn't quite as spectacular as timing a jump in the manta just right to "pancake" an opponent. The common ground vehicles are pretty abundant around the main bases and nodes, so it's not often that you absolutely have to run across the map on foot (particularly since you can instantly teleport between your own nodes, as long as they're not under attack). But the tank, the fighter, and especially the five-man leviathan supertank have slower respawn rates, so taking one out means at least a short respite.
The new onslaught mode, with its large-scale battles and fun-to-drive vehicles, is probably the main attraction of the game--though the spectacular return of the assault mode is just about as remarkable.
UT's fast, explosive weapons are still just as well suited to furious deathmatching as coordinated capture the flag matches, and somehow the addition of powerful tanks and fighters doesn't throw off the balance. While UT 2004 has no formal character class system, anyone can play a variety of roles, since standard weapons and ammo are easy to come by. Running over the weapon locker pickup points that are commonly located around bases and nodes instantly gives you a varied weapon loadout.
The link gun, introduced in UT 2003, is more multipurpose than ever because it now repairs vehicles and nodes and even makes capturing nodes faster. The new AVRiL guided missile single-handedly evens the game out by making it possible for anyone to take out a high-flying raptor or a fast manta, as long as a lock is maintained on the target. The three other new weapons are more specialized. A mine gun spits out a few autonomous spider mines that will swiftly close with any nearby enemies; a grenade launcher rapidly spits out timed charges; and a laser painter can be used to launch a devastating air strike from the unpiloted phoenix bomber. Although onslaught's vehicles seem to steal the show, it's the infantry that's in the best position to capture and defend critical nodes. Even better, there's no need to waste time defending rear guard positions, since not only are these nodes safe from attack, but in a smart design choice, freshly spawned vehicles are off-limits to enemies. However, if abandoned, they're fair game for any player.


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Toshiba DVD Recorder / VHS Combi, With Built-in Freeview Receiver And HD-upscaling
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With this fantastic all-in-one Toshiba DVD player and recorder, you can enjoy today's 50 free digital TV channels, continue playing your favourite videos from yesteryear, or experience higher-definition DVDs using the upscaling DVD player. For safe-keeping, record your old camcorder and video collections to DVD thanks to the Toshiba DVD Recorder!In just one machine, and at the touch of a single button, you can play & watch:
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Customer Reviews
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Toshiba DVD recorder/VHS combi
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08 Feb 2013
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By Mr Davidson, 23 Dec 2012
Although my original M/C was found to be faulty with a DVD drawer which refused to operate, it was collected and replaced with an alternative M/C within a week, which is working to satisfaction.
The only problem up to now has been my inability to be able to select AV2 on the input select which currently allows only AV1 and DV but this may be down to my ignorance and could possibly be rectified by fitting a HDM1 connector.
Other than that, I have found everything to be as expected and look forward to a trouble free experience for many years to come.
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As one not used to technology, I find that the manual is not easy to follow and we have no television engineers in the area our last one having left about 6 months ago. So setting up is extremely difficult. the product appears to be just what I want
By Mr Bowers, 13 Feb 2012
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By Mrs Lack, 27 Dec 2011
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DVD combi player
By Mr BLACKBURN, 22 Nov 2011
This machine performs well, good reproduction, easy to opperate, my only critisism is that I cannot delete unwanted channels on the Freeview option or sort them into a usable order as I can on my freeview box
By Mr Drake, 20 Nov 2011
This item is working ok!


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Recent graduate from Syracuse University with the Bachelor of Industrial Design. Seeking career and networking opportunities in New York City area. An experienced industrial designer with strong background in rendering, packaging, prototyping as well as user testing. Enjoy working in teams as well as independently.
Please contact me for any inquiry!
Fecha de publicación 23 de agosto de 2012
Dimensiones Apaisado estándar 68 páginas Papel estándar
Categoría Educación
Etiquetas reyner, joelianto, industrial, design, thesis, 2012, syracuse, university, indonesia, gorontalo


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Delta-Northwest Merger Becomes Visible to Customers with Introduction of Combined Domestic Products
Changeover includes employee uniforms, airport signage, and
enhanced onboard products and services
ATLANTA , March 30 /PRNewswire-FirstCall/ -- Seattle -based flight attendant Christie Colegrove , a 25-year Northwest Airlines veteran, will hang up her Northwest uniform today in exchange for a new Delta Air Lines' (NYSE: DAL) uniform. Colegrove is joining nearly 40,000 flight attendants, pilots, airport lounge representatives, ticket counter and gate agents who today will don Delta uniforms - one of the first outwardly visible signs that the two airlines are now one.
(Logo: http://www.newscom.com/cgi-bin/prnh/20090202/DELTALOGO )
By the end of next year, nearly 250 pre-merger Northwest mainline aircraft will be painted in Delta's red, white and blue flagship colors. To date, 33 Northwest-branded aircraft have already been repainted. Also by year's end, all Delta- and Northwest-operated mainline aircraft will feature similar interiors, including Delta's standard blue leather seats and carpet.
"In just five months, Delta has made significant strides to bring together the best of both airlines for the benefit of our customers, employees and the communities we serve," said Richard Anderson , Delta's chief executive officer. "We're working hard to integrate every aspect of the travel experience - from onboard products, to aircraft exteriors and cabin interiors, to frequent flyer programs - so that all Delta customers worldwide enjoy one best-in-class experience."
Delta and Northwest made aviation history last October in a merger that created the world's largest airline with service to 379 destinations in 66 countries, more than 6,000 daily departures and more than 170 million customers served annually. Until now, significant post-merger changes - such as synchronizing flight schedules, aligning route maps, integrating technologies and workgroups - have largely taken place behind the scenes.
"I've been wearing my uniform for 19 years. It was time for a fresh, new look," said an excited Colegrove. "Delta is moving the industry forward with a great new uniform that shows our professionalism and pride in how we look, act and serve."
Product and Service Enhancements
Visible product and service improvements happening this week on Delta-Northwest flights throughout the United States include:
For more details, go to news.delta.com
Five-month Merger Milestones
This week's integration of domestic products and services builds on merger milestones already completed since the closing of the Delta-Northwest merger on October 29, 2008 , including:
Delta is continuing its progress to achieve a single operating certificate by the end of the year.
Satellite uplink available
Media are invited to cover the historic changeover beginning Monday, March 30 using Delta-provided footage of aircraft being painted from Northwest to Delta, signage being changed from Northwest to Delta, pre-merger Northwest employees donning the new Delta uniforms and employees serving new food and drink options onboard Delta flights.
The uplink is available at the following times and coordinates
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Delta Reaches Seniority Integration, Union Representation Milestones
Additional seniority integration recommendations made; third workgroup resolves representation issues.


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Search 0 items in your bag |
MenswearQuality and value mark our collection of men'd clothing. A wide selection from casual to smart clothing including men'd footwear, trousers and shirts. Some styles are available in short or longer lengths with footwear in wide and extra wide styles.Sort By: 2 Items Found for Footwear Cushion Walk Mens Shoes Standard Fit £30.00 More colours available Cushion Walk Mens Shoes Wide Fit £30.00 More colours available Sort By: |


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Here's a deliciously hearty stew that gets a big contribution from a small amount of beef. The secret is browning the meat first for richness and depth, then slow cooking it along with flavorful veggies and a savory combination of tamari, red wine vinegar and...
These tender raisin-stuffed cakes have a delicious toasted millet crust when they've finished baking. For a filling breakfast serve them alongside sausage links and fresh fruit.
This colorful, main-course pasta dish features a garden of vegetables enhanced with the rich flavor of turkey sausage.
Pot roast delivers great flavor for an affordable price at about $2.40 per serving. Alter this recipe's cooking time to suit your needs, using the high-heat setting on your slow cooker to speed things up, if you like.
Create a meatless alternative to traditional Swedish meatballs with millet and vegetables for your next holiday gathering. Puréed walnuts create a rich and creamy sauce for serving. Try as a main course or with toothpicks for appetizers.
This rich, impressive dish gets its inspiration from France's famous beef Bourguignon and takes a deliciously vegetarian twist (or vegan, if you replace the egg noodles with egg-free pasta).
The autumn flavors of pumpkin and nutmeg along with sweet corn, tomatoes and creamy cheese will make this baked pasta a new family favorite.
Impressive, yet simple with whole grains and arame, a mild sea vegetable. Feel free to add more herbs or top with toasted sesame seeds.
In a modern twist on a game-day classic, cauliflower turns into the surprisingly creamy base for this white bean and chicken chili with mild poblano peppers. Serve sprinkled with sliced green onions and shredded mild cheddar or monterey jack.
As a tribute to the origins of chocolate, this creamy and spicy hot cocoa is perfect to warm and soothe the soul.
Try this delicious "pasta" made from strips of summer squash and zucchini tossed with tomatoes, olive oil and fresh basil and oregano for a dish packed with bright flavors.
Combine your favorite sausage with a sauté of fresh onions, bell peppers and zucchini, then serve over polenta for a quick and satisfying meal that looks as good as it tastes. Starting a meal with the right ingredients makes all the difference in getting it on the...
This refreshing ceviche, best served very cold, is quick to make because the shrimp are boiled first. If you like your food a bit spicy, leave the seeds in the jalapeño.
This quick-off-the-grill "fireworks" dish bursts with color and flavor. A gas grill makes it a snap to prepare, though the asparagus, squash, red peppers and eggplant can be easily sautéed as well.
Light and flaky, halibut is an ideal choice for a simple summer dinner. Here halibut steaks are marinated in a watermelon-raspberry vinaigrette, quickly grilled, and then topped with refreshingly tart watermelon salsa.
Serve this hearty soup with toasted dark bread, thinly sliced apple and a seasonal green salad. To learn how to make this recipe, watch the Secret Ingredient cooking show.
Simple and delicious, leeks may not be your first memory from past holidays, but they may be what you remember from this year.


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The Book Information Centre (BIZ) Beijing has been operating since 1998 as the overseas representative office of the Frankfurt Book Fair in Beijing, in cooperation with the Goethe Institut China. It is the central contact and information point for the German and Chinese book industries and it provides many services for professionals in that field.
To the chinese Site
We are the competent partner for inquiries on all aspects of the German and Chinese book sector.
The Book Information Centre works with a mixed mandate that balances straightforward business interests against a cultural-political mission, the aim of which is to increase the mutual transparency of the two country's book industries, and thereby to intensify German-Chinese cooperation.
The activities of the BIZ Beijing are designed to encourage the comprehensive and long-term cooperation between the book industries of China and Germany. It promotes the rights trade and it helps industry experts and stakeholders from the German publishing scene to participate in Asian book fairs. Likewise, it also facilitates the attendance of Chinese publishers, booksellers and media specialists at the Frankfurt Book Fair.
Buchinformationszentrum BIZ
c/o Goethe-Institut Peking
Ms Yingxin GONG
Sunflower Tower 1870
No. 37 Maizidian St.
100125 Beijing
Tel.: +86 10 85276983
Fax.: +86 10 85276806
E-Mail: email@example.com
As an overseas office of the Frankfurt Book Fair, the Book Information Centre Beijing undertakes many activities to support the existing interest in German books and content. These include book exhibitions, rights offers, training programmes (e.g. seminars for publishers and booksellers), participation at cultural events, professional networking trips and exchange programmes, and contacts to multipliers on the ground. It provides information through its online and offline media, including updates on the latest developments in the book market. The BIZ Beijing is also a helpful partner for German and Chinese publishers when it comes to finding translators.


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The rooms are Creta suites are not in their first flush of youth but have all the facilities that you will need. They are quite spacious and ours at least had a very large bathroom! The layout of the complex is like a little village so you seem to have quite a lot of privacy. The highlight for us however... More
- Also Known As:
- Creta Suites Koutsounari, Crete
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- TripAdvisor is proud to partner with Booking.com and Priceline so you can book your Creta Suites reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


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Internal Digital Tuner Vs Stand Alone Tuner
Posted 15 June 2011 - 09:17 PM
Posted 15 June 2011 - 11:06 PM
Peter Gillespie
Posted 08 July 2011 - 04:33 PM
Posted 09 July 2011 - 08:22 PM
Only use internal tuners in TV for the following reasons
1. The TV remote will perform all functions and if you have a disc player or PVR connected by HDMI cable the one remote can control the whole system including playingand recording.
2. If you use the component output ie the red green and blue cables the picture quality is reduced because the TV will have to redigitise the analog signal so that it can be memorised to run the display.
3. TVs are much more reliable than any Set Top Box. For example the a large power supply to run all the electronics including the tuner. Where as STBs use the smallest power supply and usually the cooling of the processor microprocessor is poor causing them to die from excess heat.
4. The receiving section of the TV and the STB have to do te same things which is to demodulate and decompress the signals. These all have to follow strict mathematical rules. This makes tuners identical from this point of view.
5. There are 3 differences between any tuners
a. Will it decompress MPEG-4 compressed signals which is used for all 3D transmissions and is required for all new TVs, PVRs and STBs.
If not it will mean that some or eventually all program streams will be replaced with an error message
b. The sensitivity and ability to reject interference
c. The ability to demodulate DVB-T2 as well as DVB-t. DVB-t2 is used overseas but not in Australia yet, however it is the only way to increase the broadcast system to increase quality eg full HD 3D transmission or the adding of more programs.
Posted 10 July 2011 - 06:32 AM
More sensible advice has already been provided by other forum members and that is the advice that should be heeded.
Posted 10 July 2011 - 10:37 AM
stefcep, on Jul 8 2011, 04:33 PM, said:
There's also a school of thought that some external devices provide superior upscaling for SD sources, than the upscaling built into a TV set. The upscaling may be "superior" by using advanced agorithms to enhance contrast without creating noticeable artifacts; and to "correct" or "hide" artifacts in the source. An argument in the other direction is that the better latest model TV sets should include reasonably sophisticated upscaling anyway. The use of an external device would be a complication without yielding a significant improvement.
alanh, on Jul 9 2011, 08:22 PM, said:
Only use internal tuners in TV for the following reasons
1. The TV remote will perform all functions and if you have a disc player or PVR connected by HDMI cable the one remote can control the whole system including playingand recording.
Edited by MLXXX, 10 July 2011 - 11:44 AM.
Posted 10 July 2011 - 11:21 AM
alanh, on Jul 9 2011, 08:22 PM, said:
Even the way they recover the COFDM signal will vary according to the design of the proprietary chipsets that they use.
There's more than one way to do the job when it comes to transmitted data recovery. And some methods no doubt work better than others.
You can't make statements like "This makes tuners identical from this point of view". It's not correct.
Identical means something very specific. 'similar' means something else, but that wasn't used. They're not interchangeable.
Posted 10 July 2011 - 02:17 PM
My Pio 507XDA easily and without issues takes my dodgy ABC signal from the antenna and displays the pic
My much newer LG7000 struggles with it
Posted 14 July 2011 - 05:38 PM
Posted 15 July 2011 - 10:59 PM


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Institute of Historical Research
Calendar of State Papers Colonial, America and West Indies, Volume 45: 1739
K. G. Davies (editor)
Year published
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'Appendix III: Naval Officers' Lists of Shipping', Calendar of State Papers Colonial, America and West Indies, Volume 45: 1739 (1994), pp. 283-285. URL: http://british-history.ac.uk/report.aspx?compid=115276 Date accessed: 09 March 2014. Add to my bookshelf
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Appendix III Naval Officers' Lists of Shipping Footnotes
Naval Officers' lists of shipping have survived for some, but not for all, British colonies. They were intended to be a record of all ships entering and clearing from British ports in America and the West Indies. They register: date of entry in record, name of ship and home-port or colony, name of master, kind of vessel (schooner, snow, etc), number of tons, number of guns, number of men, where and when built, where and when registered, particulars of cargo, port or colony whither bound or whence arrived, where and when bond given.
The following table summarizes entries of ships inwards and outwards and their tonnage for the year 1739. Under the heading British North America are included entries referring to Newfoundland and Nova Scotia; under British West Indies, Bermuda; under Europe, the countries of the Continent; and under Others, Africa, the Canaries, Madeira, and the West Indian and North American colonies of Denmark, France, Portugal, Spain and the United Provinces (Netherlands).
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The weather outside may be frightful, but a good book is always delightful. Here are a few picks from friends and colleagues of the Claremont Institute...
Gerard Alexander
Associate Professor of Politics, University of Virginia
- Napoleon: A Political Life, by Stephen Englund
This well-written volume brings to life both Napoleon and the intensely political nature of his rise, rule, and legacy. - State-Building: Governance and World Order in the 21st Century, by Francis Fukuyama
Not a page-turning thriller, but a very serious and well-informed argument that improving other countries in matters political is probably as difficult as improving them economically.
* * *
William J. Bennett
Claremont Institute Washington Fellow
Host, "Morning In America"
This has been a heavy writing year for me, and with it, lots of primary and secondary reading. For work, and leisure, five books stood out for me as out of the ordinary and worth recommending, some new, some old:
- The Battle of New Orleans : Andrew Jackson and America's First Military Victory, by Robert Remini
General Jackson was of mixed character, but Remini shows just how great was the great part of Jackson in what some historians call the "greatest American battle." - The Devil's Teeth, by Susan Casey
The subtitle tells it all: "The story of obsession and survival among America's Great White Sharks." I almost took the boat to the Farralons with my son when we were in San Francisco, but--truth be told--we both got scared of actually being too close to the Great Whites. - His Excellency: George Washington, by Joseph Ellis
A great biography on, indeed, the nation's indispensable man. As General he lost more battles than anyone in modern history; but his victories, military and political, are nonpareil. - Colorado's Fourteeners: From Hikes to Climbs, by Gerry Roach
Updated with color maps and pictures of the beloved 14ers. - Landscape Turned Red: The Battle of Antietam, by Stephen Sears
At Antietam, they laughed, shrieked, and yelled in each others' faces as they shot each other point blank.
* * *
John C. Eastman
Director, Center for Constitutional Jurisprudence
Professor of Law, Chapman University School of Law
- C.S. Lewis's Dangerous Idea: In Defense of the Argument from Reason, by Victor Reppert
With the fight between Evolution and Intelligent Design heating up in the nation's courtrooms and school boards, it is good to revisit this perennial debate at the height of its last incarnation. Victor Repport explores C.S. Lewis's logical proof of the existence of God in this fairly readable account. - Judging Thomas: The Life and Times of Clarence Thomas, by Ken Foskett
2006 marks Justice Thomas's 15th year on the Supreme Court. With a new Chief Justice and a new Associate Justice, we'll soon know whether his mission to revive the Constitution has gained some new allies. In the meantime, this latest biography of the most thoroughly originalist Justice makes for a good read.
* * *
Brian Janiskee
Claremont Institute Fellow
Political Science Department Chair, California State University, San Bernardino
- The Long Walk: The True Story of a Trek to Freedom, by Slavomir Rawicz
Polish Army officer Slavomir Rawicz was captured by the Soviet Army during the partition of Poland in 1939. He was sent to a Siberian labor camp. The journey to Siberia itself is worthy of a book-length treatment. This, however, was only the beginning. After many months in a gulag, Rawicz and a small band of hearty souls engineer a daring escape and set out for British India. This group, by the way, included an American businessman who was snared in Stalin's purges. Their journey is a remarkable tale of survival and suffering. These men made the decision to "live free or die." Some lived, but most died. Stephen Ambrose identified this book as one of the four he could not put down. Another book on that list is…. - We Die Alone: A WWII Epic of Escape and Endurance, by David Howarth
Jan Baalsrud fled Nazi-occupied Norway and joined the British special forces. Baalsrud, along with a strike team of fellow Norwegian expatriates, made a covert landing on an isolated Norwegian fjord. Their mission was to disrupt German occupation forces. They hoped to recruit and train Norwegian partisans to assist in this effort. As happens with many military plans, theirs did not survive first contact with the enemy. Baalsrud finds himself alone. The rest of his team had been killed or captured. The remaining story testifies not only to the heroism of Baalsrud but also to that of the brave Norwegians who risked all to help him.
* * *
John B. Kienker
Managing Editor, Claremont Review of Books
- Reagan's Victory: The Presidential Election of 1980 and the Rise of the Right, by Andrew E. Busch
The University Press of Kansas inaugurates its new American Presidential Elections series with this book by Andrew Busch, an expert on both Ronald Reagan and electoral politics. From Jimmy Carter's inept malaise to the triumphant Reagan Revolution, in Busch's hands, the 1980 election was not just a turning point in American history, it is a great story with colorful characters, a dramatic contest, and best of all, a happy ending. - God's Choice: Pope Benedict XVI and the Future of the Catholic Church, by George Weigel
In July, I recommended Witness to Hope as a way to appreciate the heroic life of the late Pope John Paul II. This new book is really the concluding chapter in many ways to that opus (as the author himself admits in the Acknowledgements). The first hundred pages cover the previous pope's final years, death, funeral, and legacy, before turning to a fascinating portrait of the conclave, and the worldwide reaction to the election of Benedict XVI. Weigel is very critical of much of the coverage of these events, and the book is a lesson for the media to understand the papacy and the Catholic Church. There is also a short biography of the new pope, and a look at the issues he will need to face, including European secularism, the growth of the Church in Third World, inter-religious dialogue (particularly with militant Islam), a restructuring the Curia, and a reinvigoration of Catholic schools, seminaries, and the liturgy. - Benjamin Franklin Unmasked: On The Unity Of His Moral, Religious, And Political Thought, by Jerry Weinberger
With the approach next month of the 300th anniversary of Benjamin Franklin's birth, numerous studies of Philadelphia's favorite son have appeared in the last few years. One of the most intriguing is this book, which seeks to raise Franklin's profile among his fellow founders by showing him to be the most philosophical of the lot. Indeed, the book unmasks Franklin, revealing him to be...a Straussian! That is to say, Franklin wrote esoterically, hiding his heterodox beliefs (which owed a lot to Bacon and Hobbes, and even presaged Nietzsche) within shamelessly witty essays that ridiculed everyone and everything. Weinberger says Franklin was never angry enough to be a nihilist and he still claims him as the "First American," but even more so than Gordon Wood's interesting book, Weinberger gives us a Franklin who seems positively un-American, who rejects natural right and recognizes no distinction between virtue and vice. It is a book to contend with. - Alexander Hamilton, by Ron Chernow
Everyone around the Claremont Institute has been taking turns reading this page-turning biography, and I finally found two months to do the same. It is very harsh on Jefferson, and (to a lesser extent) Adams, but it gives a riveting portrait of the political disputes in the early republic, all while presenting a comprehensive portrait of a brilliant and often under-appreciated founder. One passage that struck me was Hamilton's definitive rebuke through the ages to those (like Russell Kirk) who like to claim that all that talk at the beginning of the Declaration of Independence was really just an empty sop to appease the French: "He must be a fool who can be credulous enough to believe that a despotic court aided a popular revolution from regard to liberty or friendship to the principles of such a revolution." Hear, hear! - The Abolition of Man, by C.S. Lewis
Back in June, our friend Steve Hayward remarked that this book is "a prologue, in many ways, to [Leo Strauss's] Natural Right and History." Well, that was enough for me. Never having read it, I plowed through the slim lectures on public education in a couple of days, delighting in the simple, crisp refutation of relativism with what Lewis refers to as the Tao, his own shorthand for the natural law or the universal recognition of objective moral truths. He points out the obvious self-contradiction in rejecting such truths and the dangers in trying to redefine human nature. "The process which, if not checked, will abolish Man, goes on apace among Communists and Democrats no less than among Fascists," he warns. "The methods may (at first) differ in brutality. But many a mild-eyed scientist in pinz-nez, many a popular dramatist, many an amateur philosopher in our midst, means in the long run just the same as the Nazi rulers of Germany." Hadley Arkes proves the point again in his own magnificent Natural Rights and the Right to Choose.
* * *
Seth Leibsohn
Claremont Institute Fellow
Producer, Bill Bennett's "Morning In America"
- Right Turns: Unconventional Lessons from a Controversial Life, by Michael Medved
This political autobiography by Michael Medved is a modern-day equivalent to Chaim Potok's The Chosen in many ways. Politically conservative Jews, conservatives of any orientation, but especially those who have come to conservatism after considering themselves liberals, will see similarities to their life stories and, on the way, receive a great modern history of America—as well as the life of one of America's premier speakers and authors on the cultural issues of the day. It's at once intelligent, historical, and humorous. At over 400 pages, I could not put it down, and read it in three days. - The World Is Flat: A Brief History of the Twenty-first Century, by Thomas L. Friedman
Agree with him or disagree with him (and there's plenty to disagree with), to me Friedman is always worth reading. He sees many issues, particularly the issues of globalization and outsourcing, through a different and optimistic lens. Full of interesting statistics and anecdotes, if these issues are of interest to you, this book will not disappoint. - Inside: A Public & Private Life, by Joseph A. Califano
I grew up reading about Califano's public work in health and drug addiction, and was drawn to many of his televised appearances on those and other political issues. Here is his personal autobiography full of great stories (from practicing law with Edward Bennett Williams, to serving President Lyndon B. Johnson, to his stint as Secretary of HEW under Carter, and beyond) and history. A liberal statesman there are too few of anymore. Today Califano does great work at Columbia University addressing the causes and harms of drug and alcohol addiction. He concludes his book on that work—perhaps some of the most important he has ever done. - The Five People You Meet in Heaven, by Mitch Albom
A great and inspiring story about life, how we don't always understand the purpose of bad or sad news, but how important it is to persevere as it will all make sense, for a good purpose, in the end. Inspiring, touching, moving. If you are going through a depressive moment or spell—this is the antidote. - South Park Conservatives, Brian C. Anderson
How the new media is helping us win the culture war. From cable news to talk radio to the blogosphere—this explains it, and gives cause for hope. Anderson makes you proud to be a part of the new movement, and new media—which if you read a blog or write one, you are. - Education Myths: What Special-Interest Groups Want You to Believe About Our Schools—and Why It Isn't So, by Jay P. Greene
From smaller class sizes to higher teacher pay, Greene analyzes almost all of the education reforms of the past twenty years or so, clearly and concisely. The truth is, as he shows, a lot different than most would lead you to believe.
* * *
Ken Masugi
Director, Center for Local Government
Some books on America I read since the last Christmas book list and would recommend:
- Albion's Seed: Four British Folkways in America, by David Hackett Fischer
- Alexander Hamilton, by Ron Chernow
- What I Saw in America, by G.K. Chesterton
Add to these a book I've begun rereading, Harry V. Jaffa's A New Birth of Freedom, and you have the material, formal, and final causes of America. I recommend Chernow's Hamilton for the man who thinks he has everything. - Freddy and Fredericka, by Mark Helprin
America as teacher of old world aristocracy is one theme of this comic novel. (See my review in Advent/Christmas issue of Valparaiso University's literary and political journal, The Cresset.) - Adventures of a Bystander, by Peter Drucker
The late Peter Drucker was far more than the "founder of the science of management"—he was a wonderful writer, as this interview with Claremont scholars revealed. Try his autobiography.
Finally, some recommendations befitting Christmas:
- The Lion, the Witch, and the Wardrobe, by C.S. Lewis
Read the book, if you haven't, before you see the movie (if you must). Some things are best left to the imagination, not perceptions and sound effects, however well done. - Truth and Tolerance: Christian Belief and World Religion, by Joseph Cardinal Ratzinger
Joseph Cardinal Ratzinger may be the most philosophic of the successors of St. Peter: Of the several books of his I've read, try this one as an introduction. "There is one divine idea of man, and our task is to correspond to this." - The Five Books of Moses: A Translation with Commentary, by Robert Alter
For those who are severe textualists on these matters and for many others as well, this extraordinary edition of the Torah is indispensable.
* * *
Richard Samuelson
Claremont Institute Adjunct Fellow
Salvatori Visiting Fellow in the American Founding, Claremont McKenna College
- In Praise of Nepotism: A History of Family Enterprise from King David to George W. Bush, by Adam Bellow
A bit on the long side, Bellow's book is well written and cogently argued. It raises an interesting and important question: is nepotism natural? We are all born into certain families, and we learn certain skills and ways of thinking. The son of a doctor is more likely to be a good doctor than someone else chosen at random. How can an egalitarian and meritocratic society accommodate that reality? - Rule of Law: The Jurisprudence of Liberty in the Seventeenth and Eighteenth Centuries, by John Philip Reid
The second verse of "America the Beautiful" concludes: "America! America!/ God mend thine every flaw, / Confirm they sole in self-control, / thy liberty in law." The idea of ordered liberty was central to America's founding but has long been under assault. Reid's book is a short, readable introduction to the legal tradition that helped give birth to America, and also an attack on the critics of that tradition. - Reconstructing America: The Symbol of America in Modern Thought, by James Ceaser
This is the best introduction to European disdain for America. It's not new, and it's not simplistic. Europe's political philosophers have long had it in for America and everything it stands for. - Journalistic Fraud: How the New York Times Distorts the News and Why it Can No Longer Be Trusted, by Bob Kohn
Unlike other critics, Kohn gives a layman's perspective in this shrewd critique of the paper of record. He is a successful lawyer and entrepreneur who grew up in New York reading the Times. He does more than show that it is biased; his book reads like a devil's dictionary of distortion—cataloging the techniques by which the Times distorts the news.
* * *
Bruce C. Sanborn
President, Upland & Marsh
Chairman, Claremont Institute Board of Directors
- War and Peace, by Leo Tolstoy
Everyone has read War & Peace but it is worth re-reading, especially with us being at war. Tolstoy, who served in a war-time artillery regiment, knows battle: cannonballs to the right, chaos to the left, some heroes here, strategy up-in-smoke all around. Tolstoy also understands Napoleon and Russia. Napoleon brings war to Europe, then to Russia; all the while, Russia's elite preen and speak in French—up until Napoleon ravishes their homeland. Tolstoy is clear they've forgotten what it is to be Russian. Today some Americans are in the same boat—or maybe it's more accurate to say, in the same salon, sporting berets. - Don Quixote, by Miguel de Cervantes
From Claremont's Christmas past, I followed Claremont Senior Fellow Tom West's suggestion and read Don Quixote. It's laugh-out-loud funny in parts and eerie how grandees like Napoleon (e.g. addressing the Moscovites in War & Peace) and Saddam (e.g., at his trial) can sound like the Don. - The Iliad, by Homer
WAR!, what is it good for? Well, for one thing, for keeping America free. For another, for giving Homer material for The Iliad. On a road trip in October, I put Derek Jacobi in my tape deck reading the Penguin-abridged, Robert Fagles translation of the Great Poem. At trip's end I called my college-aged daughter and said, "I get why the ancient Greeks didn't make a big deal about not having Barnes & Noble. If you've got a rhapsode reciting The Iliad to you, well, it's great." My daughter, who sees me as a cross between the other Homer (Homer Simpson) and Inspector Clouseau, asked, "Dad, how sure can you be about the Greeks? I mean, as good as their English was, did they have the Fagles translation?" "I see your point," I noted, "but still." - Duty-Bound: Responsibility and American Public Life, by Mark Blitz
A political philosophy professor at Claremont McKenna College, Mark Blitz has written a book that is short but not easy to read right; in those two regards, it's like Machiavelli's The Prince. On the back cover (of Duty Bound) Harvard's Harvey Mansfield, a translator of The Prince and a former teacher of Mark Blitz, calls it: "a brilliant and original essay on virtue today"—again then, it's like The Prince, though with the significant difference that Duty Bound is for and about Americans: citizens, statesmen, and political thinkers. The book has a surprise ending that gets the reader contemplating what might bring greater fullness to John Locke's politically influential understanding of happiness, somewhat the way The Iliad might be understood to get a fuller-ness from The Odyssey, the ultimate road trip with a happy ending.
On to more road trips. Merry Christmas.
* * *
Tom Karako
Director, National Security Programs
- The Powers of War and Peace: The Constitution and Foreign Affairs After 9-11, John Yoo
This book will soon become a must-read for students of executive power and the constitutional issues of foreign affairs. Future writers on the subject will not be able to avoid grappling with Yoo's comprehensive, and persuasive, treatment. The book does not focus specifically on post-9/11 events as the title might seem to suggest, but it need not do so to be relevant and instructive for how to think about the national security problems of the 21st century, both in the war and terrorism and elsewhere.
The book represents a culmination of over a decade of work. Perusing the chapter titles, the book in some ways appears to be a compilation of the many fine law review articles the author has published on such subjects as globalization, the allocation of war powers between the political branches, the use of force in Kosovo, congressional-executive agreements, and the curious collection of issues implicated by the convoluted history of the ABM Treaty.
Some of the constitutional questions he wrestles with are the problem of self-executing treaties and the interchangeablity of treaties and executive agreements. Behind this technical-sounding academic language, however, are principled and basic issues—the relation of the separation of powers and the concern of government by consent. Yoo deals with these issues masterfully.


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Ronald M. Coleman |
Associate Professor, Biological
Sciences |
Latest News
STEM talk by Ron Coleman, Tues Feb 21, 2012 Here is a streaming video of this talk
Made at Sac State: NSM. My segment is in the Outreach portion.
My other website:
Cichlid Research Home Page <http://cichlidresearch.com>
A web site dedicated to collaboration between scientists and hobbyists interested in cichlid fishes (family Cichlidae), featuring extensive information about cichlids, plus the online science experiment known as the Cichlid Egg Project.
Committees and Campus Groups I am associated with:
AITC Academic Information Technology Committee, Chair and NSM representative; Computer system status: http://www.csus.edu/irt/systemstatus/
Administrative Computing Advisory Council, Faculty representative
Biological Sciences Laptop Cart faculty advisor
Biological Sciences Executive Committee (2013-2014)
Canada Exchange Committee (for CSUS Study Abroad program)
C.O.A.S.T. (CSU Council on Ocean Affairs, Science and Technology)
CREST (Center for Regional Environmental Science and Technology) Advisory Council
CSUS Student Research Competition (Faculty advisor)
Ecology Colloquium Series Fall 2013
EEC Ecology, Evolution and Conservation Group
Expanding Your Horizons 2013
Field Biology Group (Faculty advisor)
McNair Scholars Program (Scholar mentor)
Moss Landing Marine Laboratory (Alternate CSUS representative to MLML)
Museum of Ectothermic Vertebrates (Curator)
NSM Academic Council (Vice-Chair 2013-2014)
Department of Biological Sciences IT (Instructional Technology) committee
OTS REU (Research Experience for Undergraduates) Summer 2010, Costa Rica
River City Science Project
Tree Campus USA Advisory Committee
WRPI (CSU Water Resources, Policy and Initiatives)"The buck stops here". Feel free to contact me with issues related to the above groups and committees.
HIGH SCHOOL/MIDDLE SCHOOL Students: Are you interested in coming to Sac State for a college degree and are you interested in fish? Click here for the "I want to study fish at Sac State " webpage.
VISITORS: I strongly believe in the idea of public education and public universities. The Evolutionary Ecology of Fishes lab is your lab too and we welcome visitors to see what we are doing. If you want to visit, please send me an email and I will do my best to arrange a time for you to visit.
-- Ron (email@example.com)DONATIONS/SUPPORT: Yes, we do accept donations of money, equipment or supplies to help us do what we do. Various manufacturers, organizations and individuals have generously supported the work of myself and my students over the years. Thank you.


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Nike BMX - Baton Rouge
A BMX video by Nike Action - 5,862 views
Garrett Reynolds, Chad Kerley, Dennis Enarson, Nigel Sylvester and Simone Barraco handled the streets of Baton Rouge for three days, and came back with some incredible footage. Is three days in a city long enough? With this crew it sure is! Filmed and edited by Ryan Navazio


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Book Description:Milliken's Reading Well! series provides teachers and parents with a wide variety of activities to use at home or in the classroom to enhance your reading program. Reading materials and styles of writing include realistic fiction, biography, poetry, fantasy, informational articles, myths, legends, tall tales, and plays or skits. The comprehension activities have been selected to provide opportunities for students to practice a variety of reading skills. A list of comprehension skills for all grade levels is included on the Reading Comprehension Chart on page 1. A variety of assessment rubrics helps you track progress in achieving those skills. Each book in the series is sequential, allowing students to build on skills previous learned. The various levels available allows you to select the one most appropriate for an individual student or class. / Reproducible Book / Language Arts, Homeschool, Reading
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Games | Minutes | Goals | Assists | Shots |
3 | 101 | 0 | 1 | 9 |
Italy coach Cesare Prandelli selected a handful of players few would have backed for Euro 2012 picks at the turn of the year, with Diamanti among those making the squad without playing a role in the Azzurri qualifying story for this tournament.
At the age of 29, this former Livorno, West Ham and Brescia attacking minded midfielder is hardly a novice, yet he is new to the international set-up having been overlooked by Italian national team selectors throughout his career.
An unpredictable performer, he is likely to be used as an impact substitute at Euro 2012, with his ability to turn a game with a moment of magic making him a handful for opponents whose legs may be tiring.
Every team needs a player with something a little different in their repertoire and Diamanti could be that man for Italy.


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SOURCE Neuralstem, Inc.
Updates on NSI-566 ALS Phase II - cSCI Phase I - Stroke Phase I/II, and NSI-189/MDD
Live Audio Webcast to Air on Tuesday, January 14, at 3:30 p.m. PT
ROCKVILLE, Md., Jan. 13, 2014 /PRNewswire/ -- Neuralstem, Inc. (NYSE MKT: CUR) announced that President and CEO Richard Garr will present at the sixth annual Biotech Showcase (http://www.ebdgroup.com/bts/index.php) in San Francisco on Tuesday, January 14, 3:30 p.m. PT, in Room Powell (Track D). Garr will present a business overview, including updates on ongoing and planned clinical trials. Garr will provide a progress update on NSI-566 cell therapy trials including ALS Phase II, chronic spinal cord injury Phase I, and ischemic stroke Phase I/II in China. Garr will also update the status of its neurogenic NSI-189 small molecule drug which stimulates new neuron growth in the hippocampus, which completed a Phase I safety trial, in major depressive disorder, in the fourth quarter of 2013.
(Logo: http://photos.prnewswire.com/prnh/20061221/DCTH007LOGO)
The audio webcast will be available in real-time at http://www.media-server.com/m/p/p65iz6pt, with replay beginning approximately two hours following the presentation, and archived for one year. The webcast link will also be posted on the Investor Center home page on Neuralstem's website: www.neuralstem.com.
About Neuralstem
Neuralstem's patented technology enables the production of neural stem cells of the brain and spinal cord in commercial quantities, and the ability to control the differentiation of these cells constitutively into mature, physiologically relevant human neurons and glial cells. Neuralstem's NSI-566 spinal cord-derived stem cell therapy is in Phase II clinical trials for amyotrophic lateral sclerosis (ALS), often referred to as Lou Gehrig's disease. Neuralstem has been awarded orphan status designation by the FDA for its ALS cell therapy.
In addition to ALS, the Company is also targeting major central nervous system conditions with its NSI-566 cell therapy platform, including spinal cord injury and ischemic stroke. The Company has received FDA approval to commence a Phase I safety trial in chronic spinal cord injury.
Neuralstem also maintains the ability to generate stable human neural stem cell lines suitable for systematic screening of large chemical libraries. Through this proprietary screening technology, Neuralstem has discovered and patented compounds that may stimulate the brain's capacity to generate neurons, possibly reversing pathologies associated with certain central nervous system conditions. The Company has completed a Phase I safety trial evaluating NSI-189, its first neurogenic small molecule product candidate, for the treatment of major depressive disorder (MDD). Additional indications might include traumatic brain injury (TBI), Alzheimer's disease, and post-traumatic stress disorder (PTSD).
For more information, please visit www.neuralstem.com or connect with us on Twitter, Facebook and LinkedIn
Cautionary Statement Regarding Forward Looking Information:
This news release may contain forward-looking statements made pursuant to the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Investors are cautioned that such forward-looking statements in this press release regarding potential applications of Neuralstem's technologies constitute forward-looking statements that involve risks and uncertainties, including, without limitation, risks inherent in the development and commercialization of potential products, uncertainty of clinical trial results or regulatory approvals or clearances, need for future capital, dependence upon collaborators and maintenance of our intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements. Additional information on potential factors that could affect our results and other risks and uncertainties are detailed from time to time in Neuralstem's periodic reports, including the annual report on Form 10-K for the year ended December 31, 2012 and the Form 10-Q for the period ended September 30, 2013.
©2012 PR Newswire. All Rights Reserved.


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Eagles Change Mind on Canoe Welcome |
National Teams - USA Men |
According to reports in the New Zealand Herald, the USA rugby team has had a quick change of heart about their welcome to Wanganui, where they will be training. The team had been invited to enter the town on a waka, a traditional Maori canoe. The team had originally (according to reports) rejected the idea because they were concerned about "safety and sxecurity." But within as day they've changed their minds. Wanganui Mayor Annette Main welcomed the Eagles' change of tune, saying it meant a lot to the community. "It is clear that, when they initially decided not to take part, the Eagles had not realised that the waka trip is an integral part of the welcome ceremony at Putiki Marae on September 4. "Now that they have a better understanding of the cultural nature of the ceremony and the importance of the Whanganui River to our community, they have confirmed that they will be honoured to join the waka trip," Main told the Herald. The team will take part in an invitation-only powhiri at Putiki which will include the presentation of the team's official RWC caps. Following the ceremony they will travel on the waka from Putiki to the Waimarie berth. Mayor Main said she hoped as many people as possible would be on the riverbank to welcome the team to Wanganui. |


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Needing a vegetable casserole recipe for 8 people.
I prefer one with multi vegetables in the recipe and something you have tried and enjoyed. I am open to try something new and maybe different.
This is a family favorite...it is a tad rich but always a hit!
Swiss Vegetable Medley
1 bag (16oz) frozen cauliflower, brocolli and carrots (thawed and drained)
1 can cream of mushroom soup
1 cup shredded swiss cheese
1/3 cup sour cream
1/4 tsp pepper
1 jar (4oz) chopped pimento
1 can fried onion
Combine soup, vegeteables, 1/2 cheese, sour cream, pepper,pimento, and 1/2 onions. Pour into casserole. Bake covered @350 for 30 minutes. Top with remaining cheese and onions. Bake uncovered for 5 mins.
SWEET POTATOE STREUSEL SQUARES (Serves 12)
3 lbs sweet potatoes peeled and cut into 1" cubes
Salt to taste
1/4 cup butter at room temperature
1/4 cup sugar
1 cup half and half
2 eggs
1 tsp vanilla extract
1 cup packed light brown sugar
1/2 cup flour (may need more if topping is too thin)
1/2 cup butter at room temperature
1 cup pecans
1 cup sweetened flaked coconut
Cook potatoes in boiling salted water until tender. Drain water when cooked and add 1/4 cup butter and sugar. Mash potatoes until almot smooth. Add half and half, eggs and vanilla and mix well. Season with salt. Spread into a 9x13 glass baking dish (buttered).
Rub brown sugar, flour and 1/2 cup butter in bowl until moist crumbs form. Stir in pecans and coconut. Sprinkle over sweet potato mixture.
Bake at 350 for 40 minutes or until fillling is set and topping is browned. Let stand for 10 minutes before serving. Cut into squares.
I had these at an executive dinner party and they were fantastic! Everyone raved about them so the Hostess gave out the recipe. I will put them on 2 replies so as not to confuse.
1 stick butter (4), melted
1 large onion, chopped
1 small green bell pepper, chopped
1 small red bell pepper, chopped
3 eggs
1 cup sour cream
1 can (16 oz.) creamed corn
1/3 cup yellow corn meal
1/4 tsp salt
1/4 tsp pepper
1 cup cheddar cheese, shredded
In a medium sauce pan, heat 2 tablespoons of butter over medium heat. Add onions and peppers and cook until softened, stirring occasionally. Remove from heat.
Combine remaining 6 tablespoons butter, eggs and sour cream in a large bowl. Whisk together until smooth. Mix in corn, cornmeal, salt and pepper. Stir in cheese and onion/pepper mixture.
Turn into a 2-quart buttered baking dish. Bake in preheated 350 degree oven for 30 - 35 minutes, until puffed and golden.
Serves 8
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Found the same room at a different price? Tell us, and we'll offer to match it.
Directions - Hôtel Saint Germain, Paris
Hotel Saint Germain is a three star hotel situated in the historical quarter of Saint Germain des prés - a small area within the heart of Paris. The hotel welcomes you with friendly and refined surroundings, where you will find the comfort and tranquility needed for a pleasant stay in Paris. Hotel Saint Germain is an ancient five floor town house with a lift. This is a place where it feels good to be inside whether its relaxing in the living room surrounded by its authentic beams or the library with its deep and comfortable lounge chairs.
The patio is the ultimate area to enjoy a moment of tranquility after a day in town or at work.
The 29 soundproof bedrooms have all been developed and equipped with our guests needs in mind. Each one has its own individual style and is decorated with Louis Philippe and Empire furniture. Every room has air conditioning, a television, a telephone, an individual safe and a wireless connection which is available through out the Hotel. Famous for the many well known writers and artists that have dwelled within this quarter, Hotel Saint Germain allows you to totally immerse yourself into the spirit and magic of the area that surrounds you.Situated in the heart of Paris the museums Orsay, Rodin, the Louvre, the Chapel Notre Dame, The Chapel of Our Lady of the Miraculous Medal, the gardens of Tuileries and the Palace Bourbon are all within walking distance from the Hotel. There is also the house of antiques in Rue du Bac or one can visit the surrounding famous stores such as Armani, Kenzo, Yves Saint Laurent and Sonia Rykiel and Paul Smith.
DirectionsView directions provided by hotelHow to get to the hotel: Tube:Rue du Bac Solférino Sèvres Babylone Musée d'Orsay (Rer) Attractions:Musée d'Orsay Pont Royal Rue de Rennes Saint Germain des Prés |


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Nov 12, 2013
Networking Reception: 11:00 am - 12:00 pm
Luncheon and Awards Presentation: 12:00 pm - 1:30 pm
Grand America Hotel
Imperial Ballrooms A & B
555 South Main Street
Salt Lake City, Utah 84101
Utah Business magazine along with presenting sponsors Rocky Mountain Power and Big D Construction is pleased to announce the 2013 Sustainable Business Awards! This program honors the best sustainable business practices and efforts in Utah! Recognizing companies, communities and individuals who are making strides in environmental sustainability. Join us in celebrating these outstanding companies making a difference with their sustainable practices during a special event at The Grand America on November 12, 2013!
Individual seats are $75 and table sponsorship's which are available on a limited basis include a display table and recognition in the event presentation and program.
Please contact Rebecca at events @utahbusiness.com with any questions or for addtional information.
We look forward to seeing you in November!
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1965 Dodge Cornet 440 2 door Hardtop, Great White Finish with Factory Rare Maroon Accent Top, Beautiful Black Buckets Seat and Console Interior, Excellent... More
1965 Dodge Coronet 440 the heads are 440 and have been redone, new cam and bearings, lifters, pistons, rods, rings and bearings, and the... More
This 1965 Dodge Polara comes to us from its long time owner who acquired the car when he was in high school in the... More
1965 Dodge Coronet 440 for sale in Chicago Illinois. This Coronet for sale has been in the same family since new and is remarkably... More
1965 DODGE CORONET. . . . .STREET RACER !!!!!!. . . This is a rare car, pretty close to original condition, has not been... More
1965 Dodge Coronet 440 for sale in Chicago IL. After a brief absence the Coronet name was attached to the former full-size models in... More
1965 Coronet 500 Original California Car, with only 57K Miles! 273 V8 Automatic Transmission Power Steering Beautiful White Bucket Seat Interior with Rare Gold Carpeting Factory Console Factory Coronet 500 Spinner... More
1965 Dodge Coronet 500 History The Coronet was a full-size car from Dodge in the 1950s initially the division's highest trim... More
1965 Dodge Dart Charger 273, D Dart: a true collector's car, one for a collection of unique, historical cars. This is the earliest known... More


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Pictures: Florida's worst natural disasters
Image 29 of 49
Florida's Worst Natural Disasters: Hurricane Ivan( Hilda M. Perez, Orlando Sentinel / September 17, 2004 )
Areas affected: Windward Islands (especially Grenada), Venezuela, Jamaica, Grand Cayman, Cuba, Alabama, Florida, Louisiana, Texas and most of the eastern United States
Date: September 2004 Death toll: 91 direct, 32 indirect Damages: $18 billion (2004 USD) |
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FasTracks West Rail Line Corridor, LRT Extension Final Design
Denver, Colorado
The West Corridor was the first project to begin final design under the Regional Transportation District's (RTD's) FasTracks program. The 12.1 miles of light rail will run between Denver Union Station and Jefferson County Government Golden Station, adding 11 new stations, six park-n-rides, and three new call-n-rides. It connects significant destination hubs including the Auraria Higher Education Center, INVESCO Field at Mile High, the Denver Federal Center, and the Jefferson County Government Center.
Project Award:
2013 Merit Award for the 6th Avenue LRT Bridge component of the project, ACEC Colorado
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Space Shuttle Endeavour Route and Conflict Mapping
Los Angeles, California
The Space Shuttle Endeavour has a new home in the City of Los Angeles, but getting there was no small feat. DEA employed 3D mobile laser scanning technology to collect data and identify obstacles along the 15-mile route.
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US 97: Lava Butte - South Century Drive
Deschutes County, Oregon
Central Oregon's busiest highway, US 97 in Deschutes County, traverses some of the most sensitive and scenic wilderness in Oregon. It serves the mobility needs of local communities and industry, and provides access to local visitor attractions. It is the second most important north-south highway corridor in the state, following Interstate 5. Traffic volumes are expected to double in the project area over the next 20 years, and major elements of US 97 did not meet the design and operational standards required to accommodate this increase. The resulting congestion and the potential for accidents would significantly impact mobility and safety. Safety for multi-modal users accessing several popular destinations along the highway was also a concern. In addition, the highway bisects identified wildlife corridors and impacts critical wildlife habitat, including the State's mule deer population.
Project Awards:
2012 Exemplary Ecosystem Initiative for Exceptional Environmental Stewardship, Federal Highway Administration
2012 Honor Award, ACEC Oregon
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Bellevue Towers
Bellevue, Washington
Bellevue Towers is a twin-tower high-rise development in the heart of the rapidly urbanizing core of Bellevue. DEA provided multidiscipline support for this 1.2-million square foot project that includes 550 residential units rising above a seven-floor, mixed-use podium that accommodates more than 16,000 square feet of retail space and parking for more than 900 vehicles. Sustainability was a major component of the overall design, and the project achieved LEED Gold certification.
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Coos Bay Channel Modification Section 203 Feasibility Study/Environmental Impact Study
Coos Bay, Oregon
As larger port authorities reach capacity on the US West Coast, small to mid-size ports are seeking opportunities for economic development by expanding their facilities. In order to authorize the channel as a federal channel eligible for maintenance dredging by the USACE, the Port is conducting a combined Draft Feasibility Study/Environmental Impact Statement (FS/EIS) of potential navigation improvements under the authority granted by Section 203 of the Water Resources Development Act (WRDA), 1986. The FS/EIS will propose modifications to the Lower Coos Bay Navigation Channel, to accommodate larger deep draft vessels while providing a net positive local, state, and federal economic and environmental benefit. The Port contracted with DEA to lead the FS/EIS process, consisting of four phases: (1) Public Scoping, (2) Detailed Technical Studies, (3) Draft FS/EIS Development, and (4) Final FS/EIS Development and Approval.
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Kittitas Valley Wind Power Project
Ellensburg and Cle Elum, Washington
The Kittitas Valley Wind Power Project consists of 48, 2.1 MegaWatt (MW) Suzlon wind turbines and has the capacity to generate up to 101 MWs of renewable power. The electricity generated will serve an estimated 28,000 households while simultaneously reducing an estimated 168,000 tons of greenhouse gas emissions per year. As the engineer of record, DEA provided BOP civil, permitting, surveying, and construction services for the project. The project infrastructure includes 15 miles of site roads, 3 miles of public road improvements, 48 turbine sites, a 10-acre laydown area, and a 6.6-acre project substation/operations/maintenance facility with an interconnection substation to BPA transmission lines.
Project Award:
2012 Engineering Excellence Silver Award, ACEC Washington
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"I feel like every game, every round it's less pressure,'' Caldwell said. "We've played looser as we've gone through. As you continue to win those big games you gain a lot of confidence.
"I think we've always been a confident group, but regardless the last couple of years we haven't been able to get past Lincoln County in the sectionals. We've just gained a different type of confidence.''
Hurricane's trademark has been its offensive firepower during the regular season, and it has bailed out the Redskins in the postseason. Hurricane has pounded out 48 hits, including six home runs, and scored 35 runs in its five tournament games.
Rogers has three round-trippers in the playoffs, including homers in three straight games leading up to the region final. Sophomore third baseman Emily Davis picked up the offense in the 2-0 win over SA in the region final, hammering a homer that turned Hurricane's 1-0 lead into a two-run cushion. Rogers also turned in one of her most dominant performances in the circle, firing a six-hit shutout against the Red Dragons.
That production has offset Hurricane's shaky fielding as the Redskins have committed 18 errors in the last five games, though they had none in the region final.
"We've [won in] a lot of different ways,'' said Caldwell. "We've won high-scoring games, low-scoring games and [Friday] night a tight one.''
Caldwell has pulled off quite a balancing act this season with the arrival of his first child.
"It's been busy,'' he said. "My wife is willing to watch the baby all evening and night and thankfully [the baby is] one that doesn't cry all the time.
"Sometimes it's tough, but it's not been too bad. She's only 7 weeks old, but she gets mad if we don't win. She'll be at the state tournament and be our good luck charm.''
Reach Tommy R. Atkinson at tatkin...@wvgazette.com or 304-348-4811.


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Apple's new Mac Pro looks like Darth Vader: Yea or nay?
With its six Thunderbolt ports and a "unified thermal core," Apple's new Mac Pro doesn't just sound like a futuristic piece of alien machinery, it also looks like something out of science fiction.
Far from the boxy designs of early personal computers, the new Mac Pro is compact, sleek, and nearly edgeless. The resemblance of the Mac Pro, which is aimed squarely at creative pros, to a tiny nuclear reactor is in part due to that heat sucking "thermal core" design. Heat generated from the Intel Xeon CPU and new solid-state drive (SSD) storage dissipates out through the core as the hot air rises -- a change from the typical front-to-back system of air flow in most consumer desktops.… Read more


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this tape is the best i know
A big time luthier turned me onto this stuff and said in essence "don't leave home without it" and he was right. The best binding and general purpose tape I have in my collection. I even use it to mask fingerboards for fret polishing and I use the same two pieces over and over again for all the frets and it holds up just fine!... great strong stuff.
It lives up to the 5 stars
This tape is one of those items that is always hanging around on the workbench with heaps of uses.
Wow! I have used this tape for so much more than just binding. It works miracles, especially useful for holding inlays in place.
Works great for binding as advertised. Just enough tack to hold things in place for the allotted time, but can tear if you apply too much pull when wrapping across those sharp plastic binding edges.
If you want the best binding tape well here it is. You have arrived. Look no further. I recommend this product for taping up your plastic or wood binding (while the glue is drying). loren barton
superb quality and amazing price
Good and sturdy. Works like a charm when doing binding jobs.
I used your binding tape to attach purfling strips around the edges of a demi-lune Federal card table I built. Your tape provided the required holding power to produce a handsome and tight seam.
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Xbit details AMD releasing new Vishera class CPUs the FX-6350 and FX-4350 which are 6 and 4 core CPUs respectively.
The new AMD FX processors available for pre-order at ShopBLT online store are FX-4350 as well as FX-6350. The new central processing units feature much higher (200MHz – 400MHz) clock-speeds than previous offerings and therefore it is logical to expect decent performance gains over predecessors. AMD FX-4350 costs $142.86, whereas AMD FX-6350 is priced at $154.76.


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The pistols I have are far to small for this trip but was advised to bring one along. I think I'm looking for a 44 or 41 cal but don't want to spend more than $450.00. I hate to take advantage of hard times but if you have one to sell I'm in need of one. We're going the end of August. thanks Jim
If this is for possible bear encounters you might be better served with a shotgun. The locals advise if you're depending on a hand gun it's best to file down the front sight, just in case the bear shoves it up you know where.
I know a guide up there who carries a 12 gauge loaded as follows: 2 rounds of bird shot, 2 rounds of buck shot, 1 slug. If the bird shot doesn't scare them off (he refers to this as "an application", pop him with buck shot. If that doesn't work, you have that slug to do some serious damage if he gets right up on you. A .357 won't cut it on a grizz, don't bother. If you're going to stick with the .44 idea, get one with a long barrel for accuracy. Years ago I picked up a used S&W .44 model 629 classic in stainless with a 7 inch barrel for $400 with a shoulder holster from a cop I knew. If you know any local law enforcement, they're always horse trading with guns, ask around. Good luck in your search and in Alaska.
Not my gun I am selling but this is for sale on Seattlegun.org right now. Wish I had the money because its sure a pretty peice of stainless steel. Few other 44 cal for around the same price but do not include the scope or holster. Its a few pages back on the hand gun section. WTS RUGER SS .44 MAG SUPER BLACKHAWK PACHMAYR GRIPS LEUPOLD M8-2X EXTENDED SCOPE 7.5" BBL MINIMAL USE HAS HAD SOME NICE TRIGGER WORK DONE, COMES W/ ROY'S LEATHER GOODS CAMO SHOULDER CASE NICE PIECE ASKING $675 PRICE DROP****
Not sure where to find one. But had a buddy who was a bush pilot and his prefered sidearm up there was a 454 Casull (Sp??). I fired that baby a few times, was one helluva handgun. Was a ruger, not sure on model. But was a revolver, and he did use it once, and dropped the bear (and from his story, a load in his shorts too LOL). Not sure on the price of one, but something to look at.
If you already own a 12 ga look into buying a rifled slug barrel and a sling for it. Slugs are a fisherman's best friend. I have a short barrel for an 870 wingmaster chambered for 2 3/4". Reasonable. SS
A 20" stainless steel, synthetic stock 12ga Remington 870. If your worried about kick, get a 20ga, it will do just as much damage.
I have guided single fisherman on float trips thru-out alaska--if you have never fired a 41/44 mag this is probably not the time to learn (not my idea of fun) there is no question in my experience that a short barreled 12 guage with bird/double oo buck/followed by slugs is the way to go--you should hope that you never kill a bear--check out what you are required to do-i.e. cape the animal and return it with you!!(that was the law as of 2008)
In that case, I'd look into a .454 as Jerry mentioned or the .50 S&W Magnum. Anything longer than 4" barrel is a waste, 'cause that bears going to be on you so fast you probably won't clear the holster on a 6-8". Seriously; I've seen them run. A friend was AK Fish/Game and had to dispatch 3; 2 with a shotgun loaded with 00 buck/slug/buck/slug and one with a .41 or .44 mag, don't recall. Point he was very emphatic about was a handgun doesn't cut it. I'd carry bear spray.
If you do decide on a handgun for coastal Grizz and Browns, please do yourself a favor and DO NOT use hollow points !!! For a heavy boned bear you want PENETRATION and you WILL NOT get it with hollow points. You want a round that will penetrate DEEPLY and has the ability to smash shoulders. If you need to defend yourself a lung shot will not drop a bear before he gets to you. You need to break his wheels and the only way to do that is to penetrate and for the bullet to hold together. Hard cast linotype bullets as heavy as you can get will get the job done. As for calibre......44 mag and up.
In 2001 I floated the Kanektok with three other friends. On sound advice, we did not carry any firearms. Instead, we each carried bear spray in holsters and practiced with it. We also carried small air horns, the kind you can get at a marine supply store, with about a pint size air reservoir. These are REALLY loud. We saw lots of bear scat and prints, but the closest we saw any bears was about 500 yards. I think that the area you are in makes a big difference. I know that the Inuits shoot bear along the Kanektok, so this is bound to make them less likely to approach humans. Another area might be more of a problem. Ted
Mossberg makes some "marine coat" versions in 18" and 20" that I think are 6+1 and 9+1 (2 3/4" shells). They're a tad bit more affordable than the Remington Stainless(!!). I carried the 18" when I was up there a couple years ago.
holy moley, Robert has common sense. I agree. I lived in AK for 6 yrs and will use bear spray. bears don't want a confrontation any more than we people do. It's a sad fact that too many time humans just shoot to shoot. for several years the brown bear season was closed because too many bears were killed and if you think Alaskans were not pissed at how cowardly some people can be think again. After some investigations idiots shot bears and cubs when they were not threatened. once a sow goes down, the cubs are either killed by AF&G or they die in the wild or captured "IF" there is a zoo that will take them. If more men would act like Men, and respect Bears, and just go on about your business fishing we wouldn't have such a mess. Some may disagree but AK fish & game don't write up "fishing in bear country" information that calls for shooting a bear. Too many people have not taken the time to think through and know their options. Carry a gun is fine, using bear spray first is all you need. it's why they sell it and most sensible fishermen use. U see guides in teh bush always packing guns because they don't want their insurance rates going up and you better make the kill shot count or youi'll be lucky to stay alive. You piss off a grizzly and your finished anyway. bear spray deters and it's a psycological advantage to the human. The bear doesn't feel threatened for it's life. A bullet to it's body does. Use bear spray
I have a Ruger 44 mag single action blackhawk, stainless. I bought it while I was stationed in Alaska for fly fishing. I hear what you guys are saying about the shotgun and valid points, however it's hard to fly fish with a shotgun under your arm. It's had half a box of shells shot through it...I have a shoulder holster and and a side holster (somewhere, I'll have to find them since the move) I'll sell it all for $450 firm (it's not eating anything). PM if interested.
X2. I hunt Ptarmigan way down on the Alaska Peninsula and the brown bears are super thick - like 6 to 12 sightings in a morning's walk. I never felt compelled to carry a sidearm. Just my SxS with #7 shot for birds and bear spray. My dogs have totally tripped across sleeping brown bears and the bears just get the hell out of there. They have no interest in us.


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Bar Height Black Director Chair
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Discover a variety of uses for this classic-style director's chair. This portable director
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