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Dear Business Associate: The Materials Resource Management department under the direction of Donald Groth, Corporate Vice President, MRM, is responsible for the supply chain continuum at the Detroit Medical Center. That continuum includes product standardization, acquisition, receipt, and delivery. Materials Resource Management Administration can be reached at 313.578.2660.
MMBDC Corporate One Award - 1999, 2000, 2001, 2002
MMBDC Minority Input Committee Healthcare Sector 2002
Mich Hispanic Chamber of Commerce-Corporation of the Year Award - Non-Automotive Category, 2001
TLS can be reached at 313.341.2900
CLINICAL ENGINEERING, under the direction of Makidah Mahdi, Corporate Director, is responsible for:
Clinical Engineering can be reached at 313.578.2824.
CONTRACT ADMINISTRATION, under the direction of Janet Abbruzzese, Corporate Director, is responsible for:
Supply Chain Initiatives can be reached at 313.578.3831 Bruce Lawrence, Supply Chain Project Manager Luretta Pandya, Strategic Clinical Sourcing Manager
LOGISTICS MANAGEMENT, under the direction of Mike Weathersby, Corporate Director, is responsible for:
Logistics Management (Mike and Jon) can be reached at 313.745.1701.
PROCUREMENT, under the direction of Richard Gold, Corporate Director, is responsible for:
Purchasing and contract administration for facilities + administrative services, can be reached at 313.578.2650. SUPPLIER DIVERSITY, under the direction of Ed Wagner, Supplier Diversity/Marketing Support Manager, is responsible for:
Supplier Diversity inquiries contact 313.578.2662. SYSTEMS DEVELOPMENT, under the direction of Matthew Bagazinski, Corporate Director, is responsible for:
Systems Development Analysts can be reached at 313.578.2705. Christine Blue, Analyst Eric Cracium, Financial Specialist Cherricka Hardy, Analyst Deborah McLellan, Analyst


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Quick Facts
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Paul Castellano is best known for becoming the boss of the Gambino crime family in New York City.
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Paul Castellano was born on June 26, 1915, in Brooklyn, New York. "Big Paul" left school in the eighth grade to work at his father's butcher shop and run numbers. Castellano earned a reputation for never talking about his associations, even at the cost of serving time. He was gunned down in a move by John Gotti's men to usurp power on December 16, 1985.
"There are certain promises you make that are more sacred than anything that happens in a court of law, I don't care how many Bibles you put your hand on."
Early Life
Gangster and racketeer Constantino Paul Castellano was born on June 26, 1915, in Brooklyn, New York. The youngest son of Sicilian immigrants, "Big Paul" dropped out of school in eighth grade to cut meat in his father's butcher shop and help him run numbers for mob-controlled bookies.
Castellano's early exposure to the underworld led to more frequent and more serious crimes. He spent three months in federal prison in 1934 after being arrested for armed robbery, never revealing the names of two friends who were also involved. His unwillingness to work with the police earned him street credibility among thugs in the neighborhood.
Life of Crime
In 1937, Castellano married the sister-in-law of mafia king Carlo Gambino, Nino Manno. For the next several years Castellano was involved in gambling and bootlegging, but otherwise kept a relatively low profile. Nearly two decades later, he was called before a grand jury to testify about his connections to organized crime. He refused to say a word and was sentenced to five years in prison for contempt of court. He only served seven months before being released, earning a reputation for bulletproof loyalty.
Thanks to his mob connections, Castellano's next business—a wholesale enterprise called Blue Ribbon Meats—made him a wealthy man. On the side, he and Gambino also developed the so-called "White Rackets," such as construction bid rigging, union infiltration and political corruption. After the death of Carlo Gambino, Castellano was made boss of the Gambino Crime Family. Castellano led with a quiet hand, keeping a low profile and running operations from his Staten Island mansion.
In 1985, the government enlisted the aid of Castellano's maid and lover, Gloria Olarte, to place a wire tap in his kitchen. The bug recorded 600 hours of evidence detailing Gambino crime family business, and he was arrested on March 30, 1984. Charged with sanctioning the murder of 24 people, he was released on a $2 million bond. A year later, he was arrested along with several other crime family bosses in what became known as the Commission Case, an investigation into mob control over the New York City construction business.
In 1985, Neil Dellacroce, a beloved leader in the Gambino family who had been protecting Castellano from growing mutiny among his men, died. When Castellano failed to attend Dellacroce's wake, it was the last straw. Rival John Gotti took advantage of Castellano's weakening hold on the family, convincing the majority to change allegiance. On December 16, 1985 Paul Castellano was gunned down outside Sparks Steak House in Manhattan.
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H P Lovecraft Lovecraft, the Cthulhu Mythos, and writers who continued the tradition. |
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22nd February 2010, 07:22 PM | #1 (permalink) |
Moderator Join Date: May 2006 Location: Texas
Posts: 13,433
| "Beyond the Wall of Sleep" Well, prompted by the revival of the thread on "The Hound", I've decided to throw out the possibility of discussions of some of HPL's individual tales; something I've been pondering for some time but was simply unsure there was enough interest to make it viable. Some of his stories, of course, have already seen some level of discussion, but these have chiefly been among the best known, and I'd like to see opinions, thoughts, and impressions of all types of tales from the man, greater and lesser, horrific and humorous. I don't have in mind any particular approach to the tales; just a free-wheeling discussion of various people's thoughts. I've chosen this title to start it off because it is the most recent piece I've (re-)read, and I'm in the midst of a rather detailed analysis of it, so naturally am especially interested in hearing other people's thoughts as well; it is one of his tales which receives little comment generally, which I feel is a bit unjust; though certainly an early tale, and one of the lesser ones, I nonetheless think it offers quite a bit of food for thought, and that there are numerous approaches to analysis and discussion. For the time being, I will hold off on my own take(s) here (which are really quite lengthy), and will attempt to minimize my own responses to others, save to note things I find especially interesting or that are ideas which had never occurred to me before. So... anyone interested....? |
22nd February 2010, 11:08 PM | #2 (permalink) |
Senior Member Join Date: Jun 2008 Location: Czech Republic
Posts: 1,173
| Re: "Beyond the Wall of Sleep" This story is , sadly , the only thing that remains (last time I checked) of the extensive colection of story narrations from MindWebs . I can sort of understand some copyright problems but with most of these stories , they served more as an introduction into the genre . Michael Hansen is realy a wonderfull narrator and it is to bad that one can't find a place to hear MindWebs online as of yet . And no , the recordings aren't sold anywhere either . I realy loved what the man did with Great Slow Kings , and I just loved to hear him modulate his voice to all diferent forms - from the gruff to the intelectual to the elderly . I think you would have liked his work on that H.G.Wells story about sea people - what was it , "The Abyss" ? I did find a separate recording of his reading of Frederic(k?) Brown's "The Weapon" though . Sorry for sidetracking :O |
23rd February 2010, 01:14 AM | #5 (permalink) |
Senior Member | Re: "Beyond the Wall of Sleep" I listened to ye podcast (is that whut it's call'd?) & follow'd along in me Penguin Classics edition of The Thing in the Doorstep and Other Weird Stories. The reader made some changes of his own, reading "supernatural" for "supernal." The only transcriptional error that I caught was "green" when it should have been "great." I like this tale a lot and I think it very well done. S. T. has written critically of this story but once to my knowledge, in H. P. Lovecraft: A Life, where he writes: "There are some powerful conceptions in this story; but on the whole it is marred by stilted prose, confusion in some critical points of plot and conception, and a vicious class-consciousness." This seems rather harsh; and S. T. does not touch upon the tale at all in his introduction to the Penguin edition. As I listened to the tale and followed the text, I found that it flowed quite well and that it kept my interest. The opening lines are ones that I love to speak and contemplate and mimic in my own weird fiction. The idea of an alien mind or presence inside the brain of an uncouth rustic works for me in this tale -- the idea that the ignorant man cannot understand the things of which he raved, this stuff of "dreams" which in fact is rooted to cosmic reality. It's an engaging idea, and Lovecraft handles it very well. As a weird tale, this works superbly. I always feel a chill when the mouth of Slater speaks, "Joe Slater is dead." The revelation that this cosmic being is ruled by all-too-human passion -- hatred, vengeance, a need for justice -- seems the tale's one staggering weakness. |
23rd February 2010, 04:03 AM | #6 (permalink) |
Moderator Join Date: May 2006 Location: Texas
Posts: 13,433
| Re: "Beyond the Wall of Sleep" I personally have never seen that as a weakness, but I may have to think about that view. To me, though, it has always fit with the idea that the mythological gods and beings of the classical writers were also ruled by such passions. Incidentally, given your love of Shakespeare, Wilum, here's something you may enjoy thinking about: As the motto for the tale ("I have an exposition of sleep come upon me") is from A Midsummer Night's Dream, what do you think of a possible imaginative connection between Bottom's speech concerning his dream and certain portions of the tale? I ask this because, a while back, in reading "The Tomb", I realized that HPL not only used the Aeneid for his motto for that tale, but was playing on aspects of it as a way of foreshadowing the events as well, through association. He seems to have loved taking such classical themes and tropes and playing on them in more modern terms; perhaps another example of the past reaching forth into the present to engulf certain hapless individuals, or perhaps as an example of how "modern people under lawless conditions tend uncannily to repeat the darkest instinctive patterns of primitive half-ape savagery in their daily life and ritual observances". At any rate, I'd like to hear your thoughts on the idea of any such connection between Bottom's Dream and those of Joe Slater. |
23rd February 2010, 05:19 AM | #7 (permalink) |
Senior Member | Re: "Beyond the Wall of Sleep" The one connection I see is that in both cases the "dreams" are not dreams at all but visions of reality. It is the narrator of "Beyond the Wall of Sleep" who is obsessed with dreams and what they may in fact portend. His obsession with dreams dictates his language. "At this point the thought-waves abruptly ceased, and the pale eyes of the dreamer--or can I say dead man?--commenced to glaze fishily." It is the narrator's assumption that Slater's visions are founded on dream-vision. Here we see that too much knowledge about the true nature of Time and Space is a dangerous thing, as we are warned at the beginning of "The Call of Cthulhu." Interestingly, though, this creature speaks of perhaps meeting the narrator "in unremembered dreams tonight," and perhaps this intelligent creature is not the inhuman cosmic thing that I imagined it to be, divorced from human emotions, but a creature linked to humankind -- "I am an entity like that which you yourself become in the freedom of dreamless sleep." Dreamless sleep -- how interesting. I'd like to know what S. T. sees as "...confusion in critical points of plot and conception...," although the obvious problem is how, why, such a cosmic phantom became trapped within its "diurnal prison" of Slater's mind as well as body. I am curious about the plural of "brains" -- "...the coarse brains are ceasing to vibrate as I wish." It is there in Derleth's text, and S. T.'s text is based on HPL's typescript. Upon further reflection I think this entity is not removed from humanity but that we are linked, in some relationship beyond mundane Time and Space -- and therefore its human-like emotional state is perhaps something that we learned from it. I want to see cosmic entities as distinctly removed from human traits, as Lovecraft seemed so avowed to shew; yet here he has linked this creature from an alien dimension absolutely to mundane humanity. This is what I love about Lovecraft and why I find him a never-ending source of fascinating and inspiration -- he has depths!!! |
23rd February 2010, 05:35 AM | #8 (permalink) | ||
Moderator Join Date: May 2006 Location: Texas
Posts: 13,433
| Re: "Beyond the Wall of Sleep" Well, the cosmic entity itself states that "We are all roamers of vast spaces and travellers in many ages" (D, p. 34); this, with the inclusion of the narrator as himself having such a "cosmic twin", and the opening statements, leads me to wonder if HPL wasn't indicating that we all have such, and that, as the text has it, "this less material life is our truer life, and that our vain presence on the terraqueous globe is itswelf the secondary or merely virtual phenomenon". What I was referring to with Bottom's speech is how it reflects elements of the tale, to wit: Quote:
As you say, this is one of the things which keeps drawing me back to HPL -- the layers in the man's work. And the more I read of his letters, the more evident it becomes that his mind really did tend to work on such levels, often simultaneously.... | ||
23rd February 2010, 08:20 PM | #9 (permalink) |
Senior Member Join Date: Jun 2008 Location: Czech Republic
Posts: 1,173
| Re: "Beyond the Wall of Sleep" To the story : one often overlooked aspect of the story is "the cruel empire of Tsan Chan which is to come three thousand years hence" . I often wondered if Lovecraft ever had any definite idea of what he meant by this and maybe planed to hint at it in later tales . Did he imagine some version of a barbaric tribal federation , akin to the empire of Genghis Khan , after it had taken over and temporarily subdued the "arian" people , perhaps ? |
23rd February 2010, 09:38 PM | #10 (permalink) |
Moderator Join Date: May 2006 Location: Texas
Posts: 13,433
| Re: "Beyond the Wall of Sleep" Weellll... he did mention "Tsan-Chan" again several years later, in "The Shadow Out of Time". However, I think he was referring to some views of his own, which he had expressed in letters and, to some degree, in his articles aimed at deflating the astrologer J. F. Hartmann. I'll dig out the bits I wrote on this and bring them in, if you're interested. But as far as details about this particular empire... as far as I know, he had nothing beyond that mentioned above in mind.... |
25th February 2010, 08:29 AM | #12 (permalink) |
Science fiction fantasy Join Date: Feb 2010 Location: Canada
Posts: 425
| Re: "Beyond the Wall of Sleep" This story, "Beyond the Wall of Sleep", is a mixed bag because it presents itself as a sci-fi type, but it is actually something different, or a cross between sci-fi and horror. Now, some of the concepts that it deals with are dreams, alien contact, and weird science. I think that the main focus is on alien contact with the brother of light, whatever that is. Now the only way to look at that is through personal reflection. I remember what when I myself became ambi dexterous, I had a surge of energy that lasted for over a year and I lost 60+ lbs. The thing is that I was able to rest and let one of the sides of my body control my body movement, and it appeared to be directed by something in the sky because it moved me to positions that allowed me to remain hidden from the sight of other people. Basically what I'm saying is that this notion of being controlled by an entity only occurs through one side of the body and not both sides. This is not dealt with in this story. That is fine, and what I think in the end is that Lovecraft was simply trying to describe some phenomenon related to the human body, and he used a very interesting technique that is different than psycho analysis or other theories. In the end it is just a weird tale, and this idea is reused in other stories like the Dunwich Horror. There is something to the concept but it is just better left as a story element. If God or Gods hide themselves in the fabric of space-time, or stand outside of even that, what we can see as human beings is just this sort of nonsense talk about aliens, so might as well throw it in there if that is the best that God can give us to work with it is His problem, not ours...if it makes for dumb stories. |
25th February 2010, 09:58 AM | #13 (permalink) |
Science fiction fantasy Join Date: Feb 2010 Location: Canada
Posts: 425
| Re: "Beyond the Wall of Sleep" ....adding another comment.... I don't see an edit post button, so I'll make a new post. Yes, I have recently read "The Island of Dr Moreau" by H.G. Wells. Apparently H.G. Wells is possibly the first sci-fi writer. It seems to be that he founded that type of writing but I don't know for sure. Well the point is that if I can read more H.G. Wells than I might be able to understand exactly what the difference is between sci-fi and horror. Now an important point of interest is that Lovecraft used to talk to Robert Howard apparently. If this is incorrect, than let me know. I guess that Howard wrote fiction that is classified as Sword and Sorcery. If I am not mistaken, I think that Lovecraft might have tried to write this way, but that is a speculative thought. Now, this current story "Beyond the Wall of Sleep" if it is sci-fi, the idea was made into a full scale horror in the Dunwich Horror as I mentioned. Well that is what I prefer because there are more characters involved and less contemplation. If this is sci-fi it is sci-fi due to the isolation of the narrator. Having to deal with that, Lovecraft did well here. There is a better way to write however. Well I would start to group his stories putting "Beyond the Wall of Sleep" and "The Dunwich Horror" together and "The Lurking Fear" and "Rats in the Walls" together. He missed out on being able to combine them because certainly they could be adapted to each other. That would be a worthy task. ...done for sure now....honestly there was no edit button to append this to my other post. |
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5.00 rating Great Stroller by Toni on March 15, 2009
This is my second stroller-my first was an expensive name brand that was a waste of $$$. This stroller isn't too heavy or too light, fold up is easy. I've never had a problem with it even with strolling my daughter around for walks 3x a week. Cupholders are a good convenient feature. No problems w/wheels so I don't understand why others are having probs!
4.00 rating Good stroller for the money!!! by AJ on July 31, 2007
I have searched high and low over the past few days for a stroller that would meet my needs. I wanted a tray for my baby, cup holder for myself, self-locking when folded, easy to unfold-fold, big basket and not too heavy. Now I am on my 3rd baby and have had some stroller and this one so far is the eastist I have used. It is very light weight, folds wonderfully and it reclines nicely. I would recommend this one to anybody. The only negative is that the cup holders for the parents are not that deep but in the end who really cares? The price can not be beat--I paid 70 bucks and feel that I got more than my moneys worth. |


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disability rights
To be a disabled child, or a disabled adult who needs supportive care, is to know that your life is literally in the hands of the people you rely on to love and care for you. And those people may well think that murdering you would be doing you a favor.
disability rights
"Then I was sedated and when I woke up, she was gone. She was taken away from me."
I was about 17 when I learned about the social model and it radically changed how I thought about my own body.
disability rights
This is a situation where bodily autonomy and choice are colliding and it's very, very messy.
Today is Blogging Against Disablism Day, an event organized to explore ableism/disablism and their larger social impacts worldwide. Disability hate crimes are just one of the many issues faced by the disability community.
The ADA prevents anyone from directly questioning me about it. But I always choose to. Let me tell you why.


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This section features Critical Threats work on Afghanistan, Iraq, Libya, and Russia. For further analysis on the wars in Afghanistan and Iraq, please visit the Institute for the Study of War.
Obama Flirts with Losing the "Must Win" War
Washington is full of leaks that the Obama administration is planning to end America's military presence in Afghanistan in 2016. And Congress has already slashed U.S. financial assistance to the fifth-poorest country in the world.
Putin's Olympic Gamble
In Russian President Vladimir Putin's New Year's address, he promised to keep up the fight against terrorists in Russia's North Caucasus until "their complete destruction." With the Sochi Winter Olympics less than a month away, however, it is becoming increasingly evident that Putin has bitten off more than he can chew.
Testimony: An Unarguable Fact - American Security is Tied to Afghanistan and Pakistan
A strategic partnership with Afghanistan, underwritten with aid and with troops, along with continued engagement with Pakistan, is the only hope for securing American interests and the safety of Americans in this region.
On Syria, a Weak Strike is Better than None
A weak strike is more in line with U.S. interests than a refusal to strike or, worse, congressional action blocking any attack. Not just U.S. credibility but also the will of the Syrian opposition is at stake.
What to Do About Syria: Vital U.S. Interests are at Stake
Reasonable people can disagree about the extent to which President Obama's proposed "limited strike" will secure American interests, but not about whether the interests are real or vital.
The Peril of Sequestration
Sequestration has done material harm to America's national security at a dangerous moment. The United States is putting itself, its allies, and the world order that serves America so well at great risk in a fit of absentmindedness. It is past time to start paying attention again to the consequences of this policy on our security.
Leaving in 2014
Announcing a minimal post-2014 military presence will make any sensible counterterrorism strategy impossible. It would repeat the mistake made after the Soviet withdrawal of imagining that Afghanistan no longer mattered to American security.
The Afghan Endgame
President Obama's decision to withdraw another 34,000 troops from Afghanistan over the course of the next year is unwise.
Iraq's Return to Bloodshed
Eighteen days of protests in Egypt in 2011 electrified the world. But more than twice that many days of protest in Iraq have gone almost unnoticed in the United States.
Rand Paul's Side Effects
Senator Paul's most important intellectual error lies precisely in his notion of side effects. Inactivity, too, has side effects, and those must be weighed as seriously as the side effects of proposed actions.


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The native's comments
1234…>>Last..$200 million a day? Nov 6th 2010 8:56 GMT .Ok.....so 200 million is too high.
The extreme right believes everything the tin gods from FOX spew. How absurd! I've researched these absurdities about the Obama trip and probably 99% of what Bachmann said is just plain absurd, but there they are, out there, just waiting to carry the water. How silly and stupid it makes us look in the eyes of the world. Those who believe "liberals" are just angry are naive. Liberals are happy for the opportunity for the other half of America to see how much conservatives really care for the American people. The onus is on you! You'd BETTER GET TO WORK!!
"Those who can make you believe absurdities can make you commit atrocities."...Voltaire (Perhaps like stomping women's head?)
SHORTLY after 4 a.m. on the frigid morning of July 15th, Argentina became the first country in Latin America to permit gay marriages nationwide, and to allow homosexual couples to adopt children. After over 14 hours of debate and fierce legislative arm-twisting, the Senate voted 33 to 27 to approve the bill. The measure both cements Argentina's reputation as a relatively liberal outlier in a socially conservative region, and delivers a big short-term political victory to the president, Cristina Fernández, and her husband and predecessor, Néstor Kirchner. Whether it will help or harm their effort to remain in power past 2011, however, remains very much in question.
The Kirchners' transformation into crusading gay-rights activists is fairly recent. Lawmakers repeatedly put forth the subject last year, but it received little presidential support. The politics of the issue changed once the ruling couple's Front for Victory (FPV) party lost its congressional majorities. The Kirchners were looking for a controversial bill they could force through the legislature to prove the government could still get its way, and they settled on gay marriage as the best candidate. The topic would unite their leftist base, and enable them to demonise opponents of the measure—particularly the Catholic church, with which they have long had tense dealings—as retrograde bigots. Although several opposition senators pushed for a civil-union law instead, which would not include adoption rights, the Kirchners characteristically made it clear the battle would be all-or-nothing.
The tactic succeeded in polarising the country and giving them the edge. Jorge Bergoglio, the archbishop of Buenos Aires, played into their hands by calling the proposal "a destructive pretension against the plan of God." That enabled Ms Fernández, on a trip to China, to fire back that "it is very worrisome to listen to expressions like 'war of God' or 'projects of the devil' and things that recall the times of the Inquisition." Similar exchanges played out among demonstrators at the square in front of Congress. Tens of thousands of faithful answered Catholic leaders' call for protests against the measure by marching there on Tuesday. But when one small religious group tried to return the next day, after gay-rights advocates had installed themselves on the plaza, they were quickly shouted down. "Rubbish church, you are the dictatorship," the masses chanted in rhyming Spanish.
The Kirchners eked out their legislative victory by courting senators individually: Ms Fernández even brought two allied lawmakers who had expressed objections to the bill on an official trip to China. But such tactics cannot be applied to the population at large. The first couple's victory may turn out to have been Pyrrhic. It will endear them to voters in the cosmopolitan city of Buenos Aires. But the capital is already so hostile to the Kirchners that they are unlikely to make meaningful inroads there. Meanwhile, the church remains influential in the provinces, which have tended to back the president and her husband, and are over-represented in the Senate in comparison to their population. The government may have let its desire for a quick and resounding triumph trump its long-term interests.


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Your skin is red and sore. It may even look scaly. You itch like crazy. You know you haven't been near poison ivy and you don't have chickenpox, but you're starting to worry that you're slowly turning into some kind of scaly creature from a monster movie. No need to worry. It's just eczema.
Eczema (say: ek-zeh-ma) is also called atopic dermatitis (say: ay-tah-pik der-muh-tie-tis). Atopic refers to someone who is likely to develop an allergy to something. Dermatitis means that the skin is inflamed, or red and sore.
Eczema makes your skin dry, red, and itchy. Sometimes you may even break out in a rash. It's a chronic (say: krah-nik) condition, which means that it comes and goes.
If you have eczema, you're not alone. About 1 out of every 10 kids develops eczema. Most kids who have eczema got it before they turned 5 years old, but you can get it when you're older than 5. The good news is that more than half of the kids who have eczema today will be over it by the time they are teenagers.
Skin has special cells that react when they come in contact with anything that irritates them. They make the skin inflamed to protect it. If you have eczema, you have more of these special cells than other people do. These cells overreact when something triggers them and they start to work overtime. That's what makes your skin red, sore, and itchy.
No one is really sure why people get eczema. It's not contagious — which means that no one can catch it from you and you can't catch it from anyone else. Kids who get eczema often have family members with hay fever (it makes them sneeze and have a runny nose), asthma (trouble breathing), or other allergic conditions. Some scientists think these kids may be genetically predisposed to get eczema, which means characteristics have been passed on from parents through genes that make a kid more likely to get it.
About half of the kids who get eczema will also someday develop hay fever or asthma themselves. Eczema is not an allergy itself, but allergies can be a trigger factor for eczema. That means that if you have allergies, your eczema may flare up sometimes.
Some things that can set off eczema include:
If you have a rash, don't panic! Most rashes go away. But if you have eczema, the rash may go away at first — and then it comes back again and again.
Not all rashes itch. But eczema is itchy, itchy, itchy! It often starts in the folds inside your elbows and on the back of your knees. It can also appear on your face and other parts of your body. Many things besides eczema can cause a rash. That's why your doctor is the best person to see to figure out what's causing your rash.
You may need some moisturizing lotion or cream to control the dryness and itchiness. Some people need stronger medicines called corticosteroids. Steroid ointment or cream is rubbed on your skin to help calm the inflammation. Your doctor might suggest you try an antihistamine, a medicine that comes in pill or liquid form, to help control the itching. And if all that scratching leads to an infection, you may need an antibiotic. None of these eczema medicines will cure you forever, but they can help make your skin more comfortable and less red.
Here are some other important steps to take:
Reviewed by: Patrice Hyde, MD Date reviewed: May 2012
Note: All information is for educational purposes only. For specific medical advice, diagnoses and treatment, consult your doctor.
© 1995–2014 The Nemours Foundation/KidsHealth. All rights reserved.
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In the spirit of the holidays, patients, parents and doctors share inspirational stories of healing and hope. From surviving heart failure and a near-death drowning to battling a flesh-eating disease, witness how the impossible became possible thanks to the care patients received at Seattle Children's Hospital.
Miracle Season, hosted by Steve Pool and Molly Shen, aired Dec. 8, 2013, on KOMO 4 TV. The annual holiday special celebrates the remarkable lives of Seattle Children's patients.
Mark Fadool, clinical director of mental health services at Odessa Brown Children's Clinic, provides early warning signs of mental health issues in kids and teens and urges us all to notice the signs and act early.


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KMR Milk Replacer is formulated to closely match mother's milk in protein, fat, and carbohydrates. It is fortified with essential vitamins and minerals to keep your kitten growing stronger every day. All ingredients are food grade, blended under food processing specifications.
Ready-to-use liquid in pop-top can simulates mother's milk for kittens and hamsters.
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The largest shopping district in Milan and one of the largest in Europe is the area along the Corso Buenos Aires. This street leads from the city center heading out to the commercial and industrial districts to the northeast of the city center. The majority of the shops along the road sell clothing, although there are certainly other wares for sell as well. You can often find some great bargains here, and there are also some picturesque little courtyards with quaint little shops nestled inside.
You can find a number of discount hotels in Milan near the Corso Buenos Aires. The shopping district draws tradesmen as well as tourists, and the budget hotels near the Corso Buenos Aires in Milan are very conveniently located. At either end of the two mile strip of shops you will find a metro stop on the red line (M1), which you can take straight into the city center to do your other sightseeing.
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PORT CLINTON - The Tin Goose Experimental Aircraft Association Chapter 1247 is to host Ford Tri-Motor rides at the Erie-Ottawa Regional Airport in Port Clinton today through July 4.
The aircraft is a 1929 Ford from the Kalamazoo AirZoo Museum where this plane was released last year from the restoration hangar after a lengthy and detailed renovation.
The plane is Northwest Airline's first Ford Tri-Motor and flew for Northwest in the early 1930s. It also flew for Alaska Airlines operating out of Fairbanks. In the later 1950s, it carried smoke jumpers for Johnson Flying Service, operating out of Missoula, Mont. It now has Army Air Corps ambulance markings painted on it to honor the U.S. military.
Article Photos
This restored 1929 Ford Tri-Motor aircraft is to be on display today through July 4 in Port Clinton. Aviation enthusiasts can sign up for a 15-minute flight.
Tickets can be purchased online at www.flytheford.org or by phone at (877) 952-5395. Remaining tickets can be obtained at the airport during the event. Rides begin this afternoon and continue 9 a.m.-5 p.m. daily for the remainder of the stay.
The cost is $80 for those 16 and older and $40 for children.
For more information, visit www.tingoose.org/calendarofevents.html.


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Croc Baby Croc Mini Flat Iron Light Pink
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A local favorite, The Cowgirl is Santa Fe's resource for mesquite BBQ, all-natural beef and exotic game burgers, organic salads, world famous nachos and wings, fabulous margaritas, and nightly live entertainment. Pool Room, Kid Dining and Play Area! Open seven days for lunch and late night dinner. As seen on the Food Network!
Enjoy a full bar and expanded menu which includes Josh's Barbecue and so much more!


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From waste-to-energy incinerators to a natural gas loading facility, there's lots of speculation regarding the end use of the former Woodfibre site. One thing's for sure: It's all good news for Squamish, says a forestry consultant.
Last week, Western Forest Projects announced a tentative agreement to sell the 212 acres of waterfront land that used to be the site of a pulp mill and company town southwest of Squamish. The sale comes with conditions, environmental remediation being one of them, Western project and site manager Rick Kormendy told The Chief last week.
While the timberlands management company estimates it will be two years until the cleanup is complete and the property can change hands, Squamish residents are contemplating the site's future.
A natural gas pipeline runs behind the property, Eric Andersen said. The gas source could be used by industry or the site could be used as a loading facility for the gas, he said.
The latter isn't a new idea, Andersen noted. In 1997, there was a plan to build a liquefied natural gas storage facility west of Woodfibre.
"There have been a number of proposals," Andersen said of the property's history.
In 2006, Vanport Sterilizers Inc. proposed to build a plant on the lot that would turn Greater Vancouver's garbage into bioenergy and artificial soils. The site suited the project and still does, Vanport president Richard Tennant said. Waste management operations need space, something the Woodfibre property offers, he noted. Its deep-water port is accessible by barge, the cheapest form of transporting waste and other material, Tennant said.
Vancouver ports are currently seeking a solution to dealing with tankers' ballast water, he added. Just as with garbage, the Howe Sound property could be used as a facility to process contaminated ballast water, Tennant said, noting vessels could meet the tankers, transfer the water over and transport it to the Woodfibre site.
"It is a big problem getting rid of it," he said. "[The ports] don't really have a control system for it."
The site has access to two high-pressure water sources — Mill and Cedar creeks, Woodfibre's former resident engineer George McLeod said. A pipe 20 inches in diameter from Cedar Creek carries 420 pounds of pressure per square inch to the property, he said, adding that a Mill Creek water pipe runs at approximately 235 pounds per square inch. The two creeks ensure the site has water year-round, McLeod said.
McLeod said he always thought the site would make for a great naval research site because of its unique water supply. The ocean bank in front of the site, drops 900 ft below the surface, he noted.
"There is no spawning capability on Cedar or Mill [creeks] because there are waterfalls close to shore," he added.
Since the Woodfibre mill closed in 2006, Western Forest Products has sought to sell excess energy generated by a turbine on Woodfibre Creek to B.C. Hydro. The company holds the water licences on the property. That project is moving forward, Kormendy told The Chief last week.
"We are going to be online selling power in April," he said.
The property, which lies within the District of Squamish's boundary, is zoned for industrial use. When the mill was in operation, through property taxes alone it contributed approximately $2 million a year to the municipality.
Mayor Rob Kirkham said he's pleased to see economic activity surrounding the former Woodfibre property. The district is fortunate to have such assets, he noted.
"The site has many unique attributes and so we certainly welcome the news that it will be put to productive use once again, bringing jobs and taxes to our community," Kirkham stated in an email. "Squamish is on the radar of a range of industries and we're seeing diverse interests coming forward."


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Customer Satisfaction Rises
MTA Long Island Rail Road customers rated their overall riding experience as better last year, according to the just released 2007 LIRR Customer Satisfaction Survey. The 2007 overall customer rating went up to 6.7 (out of ten), compared to 6.6 in 2006. This is the second highest overall rating since the LIRR began measuring customer satisfaction in 1991.
Significantly, the overall on-board train service rating last year went up to 6.8 from 6.6 in 2006. The 6.8 on-board service rating is the highest recorded since the customer satisfaction survey began.
LIRR President Helena Williams said, "The Customer Satisfaction Survey is a good tool to help determine how we're doing in areas that our customers consider important during their time using our service. It's encouraging to see that overall our ratings are improving. We will continue to work on those areas that need improvement and strive to do even better in those areas that are showing improvement."
Among all on-board service ratings, the highest rated attribute was courtesy of crew with a 7.6 score. The lowest rated attribute was restroom cleanliness at 4.9 which was unchanged from 2006. Boarding station ratings went up to 7.1, their highest rating in five years. The overall rating for Penn Station remained at 6.8. The highest attribute at Penn was police presence which garnered a 7.7 rating. The overall rating for Flatbush Avenue Terminal went up point two to 5.4. Jamaica Station saw an overall rating decrease of point two to 7.0.
Customer Satisfaction Surveys were distributed on westbound morning peak trains on all LIRR branches last fall. More than 11,000 were completed and returned.- Google Translate


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Ask the Right Questions When Choosing a Summer Camp
Ask the Right Questions When Choosing a Summer Camp
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While summer camps may put out glossy brochures to convince parents that their camps are the best place for children this summer, there is more to camp than sing-alongs and campfires. The Better Business Bureau (BBB) reminds parents that they should look beyond the sales pitch if they want their children to be safe and well-supervised.
"Many parents don't know that there is no government oversight of camps. It's important that they are vigilant and visit several camps to find one that best suits their child," said Randall Hoth, Wisconsin BBB president/CEO.
While summer camp has always helped children build social skills and self-confidence, today's programs are diverse and can include teambuilding programs or community service involvement. When choosing a camp for their children, parents should use care and evaluate the programs that each facility offers. They should look for a camp that provides activities that are of interest to their child and appropriate for the child's age and skill level.
Parents should be guided by their child's interests and personality when choosing a program. There are many different types of summer camp out there; including specialty camps that meet a child's specific interests, travel camps for the adventurous children, preschool camps for younger children, special-needs camps for children with disabilities and traditional camps with wide ranges of activities for children.
According to the
American Camp Association (ACA)
, parents rate fun and safety as most important to the camp experience. When considering a camp for their child, parents should ask how long the camp has been in business and check with parents of past and returning students. They can
check with the BBB
to find out about the camp's handling of complaints and its trustworthiness.
The BBB offers the following tips for parents:
Visit the camp before making a decision.
Check its location and view the living, eating and recreational facilities. Be sure to ask about safety procedures (particularly for water activities, archery and out-of-camp trips).
Assess the quality and commitment of the staff.
Find out the camp director's background, as well as the criteria used for hiring staff. It is also important to know the ratio of staff to campers. Parents sending children to specialty camps should inquire about the staff's level of expertise in the specific area.
Know the fees.
What is the total cost of tuition? Is your deposit refundable? Are there extra charges for any activities? Are meals and transportation included? Is financial aid available?
Understand the safety rules.
Find out what the rules are and how they are enforced. Ask about the camp's insurance coverage. Check the condition and safety of the facilities and equipment. Note any dangerous areas, like cliffs, swamps or water zones.
Ask about the medical care.
Check out the medical facilities to be sure they are adequate. Find out if a nurse or doctor is on site. Inquire about the procedures for transporting injured or sick children to nearby medical facilities.
Be familiar with the camp philosophy.
Know what the camps goals are and how each program offered meets those goals. Are family visits or other communication with campers allowed? How is homesickness handled?
See a typical daily schedule.
Note the camp hours, the variety of activities that are planned, the age range of the campers, what type of food is served, the pace of the day and any transportation that is involved.
Get references.
Ask parents of repeat campers about their child's experience and why they recommend the camp. Find out the camper return rate as well as the counselor return rate. Look for camps that are
certified by the ACA
– their accredited camps have met up to 300 nationally recognized standards.
For more information on an individual camp or to check a BBB Business Review on any business or charity, call 414-847-6000 (metro Milwaukee), 920-734-4352 (NE Wisconsin) or 800-273-1002 (elsewhere in Wisconsin) or visit
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Who wouldn't want to see a film in which Sir Michael Caine stars? OK, "Jaws: The Revenge" was a skipper, but at age 76, Caine has two Oscars under his belt, been knighted and has made more than 140 (with two upcoming) films. In his latest, "Is Anybody There?" Caine proves to audiences that he is — hands down — one of the best actors in the history of filmmaking.
Caine plays Clarence, an aging magician who is unwittingly placed in an old-age home. He's as bitter about being there as is the owner's 10-year-old son, Edward, whose room Clarence now occupies. Edward (Bill Milner) is obsessed with the paranormal to the point of placing a tape recorder under the beds of dying residents. He hopes to glimpse into the afterlife, while Clarence fights to save his dignity as he sinks into dementia. The two forge an unlikely friendship and share the common bond of feeling displaced.
Caine's Clarence seems eerily like "Alfie" approaching death. He is consumed with regret for having been a womanizer and losing his beloved wife, who is now deceased. Clarence craves forgiveness and eventually finds it in the most unexpected places. He and Edward end up giving each other the gift they want most in life.
"Is Anybody There?" could have gone down a dark, depressing path but instead takes the high road to sweet and touching. The chemistry that evolves between Clarence and Edward is so engrossing to watch that you want more than the film offers. But director John Crowley ("Intermission") chooses to end the story on such a pitch-perfect note, one can forgive.
Once again, Caine creates another unforgettable screen portrait. His portrayal of Clarence ranks right up there with such memorable performances as Dr. Larch in "Cider House Rules," Elliott in "Hannah and her Sisters" and the role that no one will ever forget, "Alfie." He's the centerpiece in "Is Anybody There?" and, most likely, will be recognized for it at the Oscars next year.
I loved this movie, because it delicately balanced humor and pathos; because it was all about friendships, fears and forgiveness. But, most of all, I loved it because it asks the question, "Is anybody there?" and answers it with compelling compassion.
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13 Founder's Talk & Tea
1:30 pm - 2:30 pm - Mar
13 Paris Flea Market - An Upscale Sale
4:00 pm - 7:00 pm - Mar
13 Mozart Madness 1
5:30 pm - Mar
13 Fuzion Dance Artists Presents "Dance Couture: Art Meets Dance"
7:30 pm - 2:00 pm - Mar
14 The Fine Arts Society of Sarasota Presents Their Creators & Collectors Art & Studio Tour
10:00 am - 4:00 pm - Mar
14 The Fine Arts Society of Sarasota Presents Their 2014 Creators & Collectors Self-Guided Art & Studio Tour
10:00 am - 4:00 pm - Mar
14 Paris Flea Market - An Upscale Sale
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14 Paradise in Season: New Works by Beverly A. Smith, Vladislav Yeliseyev and Joseph Palmerio
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Key member
The Church of the Redeemer celebrated its organist and choirmaster, Ann Stephenson-Moe, for her 40 years of service Saturday, Feb. 22. -
Pickin' picnic
Bluegrass fans flocked to Siesta Key Saturday for the Turtle Beach Bluegrass Picnic. -
Tick Tock
Daylight Saving Time starts 2 a.m. Sunday, so be sure to set your alarm accordingly.


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You Decide — Stupid or Cool? Check Out These 10 Gift Ideas
Bacon Soap
Bacon Soap
Do you often accidentally mix up your morning bacon and bar of soap in the shower and subsequently get out smelling like pork?
Yeah, it's never happened to us either, but this product's manufacturers think you'll be interested in smelling like Wilbur the Pig minus the greasy feeling of bathing in bacon fat.
For the small price of $5.99, you too can smell fresh off the farm when you get fresh out of the shower.
Obama Chia Pet
Presidential Chia Pets
Ch-ch-ch-chia has embraced O-O-Obama. If you don't feel like shelling out the cash to commission a painting of the president or one of our Founding Fathers, don't be dismayed. For only $19.95, you can buy a work of patriotic installation art — a piece from the Proud to be American Chia Series. In addition to Obama, George Washington, Abraham Lincoln and the Statue of Liberty are also available.
Now, that's a gift we can believe in!


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Product Description
- This pretty bracelet will give you comfortable hand touch when you wear it
- This man bracelet is the combination of beauty, elegance and durability
- This pretty bracelet is of fine workmanship, simply eye-catching and meaningful
- This pretty bracelet is made of special material with a polished and brushed finish
- This ladies bracelet can be flexed to fit on your wrist
- This bracelet has significant weight but a comfortable, casual wearing feel
- Stylish anti-fatigue and radiation protection design to the titanium bracelet would give you comfortable feelings
- Dive into your happiest times with this sweet and lovely fashion bracelet
- Titanium metals without any damage to the human body and first catered to health and long life pursuit
- Material: Titanium Steel
- Color: Silver
- Size: 20.8 x 0.8cm/8.2 x 0.3in(L x W)
- Delicate craftsmanship and the finest material provide you the best and artistic sense
- The bracelet from the back of a special material and positive and back are very perfect
- The outline of this bracelet is very simple, but it in some aspects a good piece to show your personality and sense of fashion
- Delicate craftsmanship and finest workmanship of this bracelet can be durable and used for a long time
- This bracelet is made of high quality material, durable for your daily wearing
How to Wear Bracelets:
Bangle bracelets are a timeless fashion accessory that can be worn with anything, from a designer evening gown to a pair of jeans and a white t-shirt. Bracelets can be manufactured from plastic, gold, silver, Lucite and several other different materials to dress up everything you place on your back. Wearing the bracelet in just the right fashion is just as important as the fashion you pair the bracelet with. There are several different options to consider next time to choose a new look
- Place several gold bracelets or thin bangles onto either wrist to accentuate skin that has been darkened by the sun
- Coordinate a bracelet color to match the color of your freshly manicured fingers
- Wear a chunkier bracelet that is also a watch. These bangle watches are not only fashionable, but also functional. These can be worn on either wrist and can be manufactured from materials such as plastic or Lucite for a more casual look and gold or silver for a dressier occasion
- Purchase a bracelet manufactured from Lucite that is a similar color to a favorite top or dress. This bangle can be worn to accentuate that preferred look
- Stack several different bracelets onto each wrist to give yourself a youthful, more urban look. The bracelets can be any color, shape or width, but should be limited to two of each style. Place a coordinating watch in between a few of the bracelets to make the style functional as well as beautiful
- Place a large cuff bracelet over the sleeve of your favorite long-sleeved top to give an old shirt a new life
Guide to Clean Bracelet & Charms:
- First you will need to get a sterling silver dry polishing cloth. Most of the time you can find one of these at an authorized Pandora jewelry retailer. If not check your local jewelry store
- Remove all of the charms and clips from your Pandora bracelet and sit them off to the side
- Use the polishing cloth to gently rub the bracelet starting at one end and working your way to the other end. Be very careful not to twist or pull on the bracelet, this could cause damage to it. Once you have completely worked your way over the entire bracelet, examine it, if you still see dark or dull areas go back over that spot again until it is shiny silver
- Now that the bracelet is complete it is time to polish those charms. One by one use the dry polishing cloth to gently buff away any dark areas and make each charm shine like new again. Remember to keep repositioning your polishing cloth, the silver will leave dark marks on it, try to use a clean area of the cloth for each new charm
- Now you can reassemble your shiny clean Pandora bracelet once again
Package Included:
- 1 x Bracelet
Customers' Reviews
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12-21-2011- Other Thoughts: The Pretty Bracelet is stylish without being obnoxious and it fits very well. I love it!
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12-15-2011- Other Thoughts: I really didn't expect the quality of the man bracelet to be as high as it is. The workmanship is very good
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12-12-2011- Other Thoughts: I was worried if the shape of the Bracelet was awkward, but they are just right in shape, size, and color!! Very Pretty Bracelet!
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J Kohl
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12-09-2011- Other Thoughts: I got the Fashion Bracelet for my son and he loves them. I love them too. Great price, they are a bit large, but very pretty and attractive.
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12-07-2011- Other Thoughts: These are absolutely nice! They are beautiful and stunning. I bought thing as a gift and it turned out to be a better buy that expected!
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12-05-2011- Other Thoughts: The Pretty Bracelet is perfect if you are looking for small and elegant rather than large and flashy. Overall, it is a fantastic bargain.
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12-03-2011- Other Thoughts: They are beautiful and stunning. I bought it as a gift and it turned out to be a better buy that expected! The cut reflects light and I think I might want to buy one for myself!
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12-01-2011- Other Thoughts: It is an excellent product for the price. I really likes it. You can't beat the price. It is stunning and Fashion Bracelet.
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Rotating Whip Finisher
The most popular style of whip finish tool in use today. A Whip Finisher is great tool for beginners to intermediate fly tiers to learn how to finish flies with a very clean and strong half hitch knot. Also allows fly tiers to whip around bead eyes or finish a flies head. Brass construction for long-lasting durability.
Rated 4.6 out of 5 by 10
Rated 5 out of 5 by krak a must have
this tool is a must have for any serious fly tier! it enables you to make a whip finish incredibly fast and easy! its a little tricky at first to figure it out but once you get it, you are good to go! I wont tie flies without it.
February 22, 2013
Rated 5 out of 5 by BriansFishing Used for years
This tool along with a great pair of scissors is a must. I work as a mechanic, so my fingers are rough, making it near impossible to hand finish my flies. I tie all my flies and have used this tool all the way down to a 28 hook. Once I learned to use this tool it is as simple as can be and I get a tight finish. I have been using the same finisher for 10+ yrs.
March 28, 2012
Rated 5 out of 5 by Stogie Whip Finisher
I am new to fly tying and highly recommend this tool to any beginner, it is well worth the money. Easy to use and makes a much better, faster, and easier finish knot than you can doing it manualy.
August 25, 2011
Rated 5 out of 5 by MidwestFishing Whip Finisher
Works great, is a must for quality fly finishing! Easy to use.
August 7, 2011
2 Questions | 4 Answers
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Top 25 Contributor
the smaller one (cheaper one) would be easier for tying closer to the hook. The bigger one is for finishing over material like for pike streamers and stuff like that.Details:
When you select this item, you can choose between one model priced at $7.99 or the other at $9.99. There is no explanation or description. Are they different sizes or have different features?Answers
Model FF505 (Item# 642451) and Model FF510 (Item# 922318) Whip Finishers are the same in function. Model FF505 (Item# 642451) is 4 inches in length, has a smaller throat of 1.25 inches and is used for smaller flies. Model FF510 (Item# 922318) is 4.5 inches in length, has a throat size of about 2 inches, and is used for tying larger flies.Top 25 Contributor
The cheaper one is smaller and is better for finishing right at the eye of the hook. the more expensive one is larger and is used for finishing over material like in pike streamers.A:
Size is the differance. One is made for finishing flies with cork or foam bodies where the thread is near the bend of the hook the other is made for finishing flies that have the thread near the eye of the hook.1 of 1
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Grace Cathedral is the seat of the Bishop of California, the Rt. Rev. Marc Handley Andrus.
The Very Rev. Dr. Jane Shaw, Dean, leads the mission and ministry of the cathedral.
Trustees Made up of forty volunteer members, the Board of Trustees is the statutory governing body of the cathedral. |
Chapter Composed of lay and ordained department heads, Chapter is responsible for daily cathedral operations. |
Website Design and Content Management by 1250 Media


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Nintendo Wii
Game Questions & Answers (Q&A) service lets you ask questions about video games for game consoles or PC games. So ask your ActRaiser question for Nintendo Wii and get answers from real gamers or answer questions and share your insights and experience with the rest of the gaming community.
- Developer: Quintet
- Publisher: Enix America, Inc.
- Genre: Action Adventure Fantasy
- Release Date: Not Set
- ESRB: Not Set
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Schaum's Outline of Complex Variables, 2ed
Author:Spiegel, Murray R., Lipschutz, Seymour, Schiller, John J.
1 Customer Product Review
Edition: 2
Pub Date: 2009
Publisher: McGraw-Hill Companies, The
Summary: Spiegel, Murray R. is the author of Schaum's Outline of Complex Variables, 2ed, published 2009 under ISBN 9780071615693 and 0071615695. Six hundred sixty nine Schaum's Outline of Complex Variables, 2ed textbooks are available for sale on ValoreBooks.com, two hundred twenty seven used from the cheapest price of $9.56, or buy new starting at $15.09.
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The very advanced complex variables part of the text. I took an undergraduate and graduate mixed course. The text was helpful but for my purposes overkill. I would recommend it for a hardcore graduate level complex analysis course.
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The usefulness of complex analysis in real analysis. One example is using tricks to evaluate intimidating integrals by say using Cauchy's Formula when possible. It actually would've helped more in a Mathematical Methods of Physicists and Engineers.
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Pub Date: 2009
Publisher: McGraw-Hill Companies, The
Edition: 2nd
Pub Date: 2009
Publisher: McGraw-Hill Companies, The
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[Linked to Design #706710]
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Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time The American Journal of Human Genetics, Volume 86, Issue 4, 9 April 2010, Pages 626-631 Lorna M. Houlihan, Gail Davies, Albert Tenesa, Sarah E. Harris, Michelle Luciano, Alan J. Gow, Kevin A. McGhee, David C. Liewald, David J. Porteous, John M. Starr, Gordon D. Lowe, Peter M. Visscher and Ian J. Deary Abstract Activated partial thromboplastin time (aPTT) is associated with risk of thrombosis and coagulation disorders. We conducted a genome-wide association study for aPTT and identified significant associations with SNPs in three coagulation cascade genes, F12 (rs2731672, combined p = 2.16 × 10−30), KNG1 (rs710446, combined p = 9.52 × 10−22), and HRG (rs9898, combined p = 1.34 × 10−11). These three SNPs explain ∼18% of phenotypic variance in aPTT in the Lothian Birth Cohorts. Abstract | Full Text | PDF (372 kb) |
Prioritizing Genetic Variants for Causality on the Basis of Preferential Linkage Disequilibrium The American Journal of Human Genetics, Volume 91, Issue 3, 7 September 2012, Pages 422-434 Qianqian Zhu, Dongliang Ge, Erin L. Heinzen, Samuel P. Dickson, Thomas J. Urban, Mingfu Zhu, Jessica M. Maia, Min He, Qian Zhao, Kevin V. Shianna and David B. Goldstein Abstract To date, the widely used genome-wide association studies (GWASs) of the human genome have reported thousands of variants that are significantly associated with various human traits. However, in the vast majority of these cases, the causal variants responsible for the observed associations remain unknown. In order to facilitate the identification of causal variants, we designed a simple computational method called the "preferential linkage disequilibrium (LD)" approach, which follows the variants discovered by GWASs to pinpoint the causal variants, even if they are rare compared with the discovery variants. The approach is based on the hypothesis that the GWAS-discovered variant is better at tagging the causal variants than are most other variants evaluated in the original GWAS. Applying the preferential LD approach to the GWAS signals of five human traits for which the causal variants are already known, we successfully placed the known causal variants among the top ten candidates in the majority of these cases. Application of this method to additional GWASs, including those of hepatitis C virus treatment response, plasma levels of clotting factors, and late-onset Alzheimer disease, has led to the identification of a number of promising candidate causal variants. This method represents a useful tool for delineating causal variants by bringing together GWAS signals and the rapidly accumulating variant data from next-generation sequencing. Abstract | Full Text | PDF (502 kb) |
HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF Cancer Cell, Volume 19, Issue 1, 18 January 2011, Pages 31-44 Charlotte Rolny, Massimiliano Mazzone, Sònia Tugues, Damya Laoui, Irja Johansson, Cathy Coulon, Mario Leonardo Squadrito, Inmaculada Segura, Xiujuan Li, Ellen Knevels, Sandra Costa, Stefan Vinckier, Tom Dresselaer, Peter Åkerud, Maria De Mol, Henriikka Salomäki, Mia Phillipson, Sabine Wyns, Erik Larsson, Ian Buysschaert, Johan Botling, Uwe Himmelreich, Jo A. Van Ginderachter, Michele De Palma, Mieke Dewerchin, Lena Claesson-Welsh and Peter Carmeliet Summary Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of malignancy, but their molecular basis and interrelationship remains enigmatic. We report that the host-produced histidine-rich glycoprotein (HRG) inhibits tumor growth and metastasis, while improving chemotherapy. By skewing TAM polarization away from the M2- to a tumor-inhibiting M1-like phenotype, HRG promotes antitumor immune responses and vessel normalization, effects known to decrease tumor growth and metastasis and to enhance chemotherapy. Skewing of TAM polarization by HRG relies substantially on downregulation of placental growth factor (PlGF). Besides unveiling an important role for TAM polarization in tumor vessel abnormalization, and its regulation by HRG/PlGF, these findings offer therapeutic opportunities for anticancer and antiangiogenic treatment. Summary | Full Text | PDF (2504 kb) |
Copyright © 2012 The American Society of Human Genetics All rights reserved.
The American Journal of Human Genetics, Volume 91, Issue 1, 152-162, 14 June 2012
Weihong Tang1, 30, , , Christine Schwienbacher2, 3, 30, Lorna M. Lopez4, 5, 30, Yoav Ben-Shlomo6, Tiphaine Oudot-Mellakh7, Andrew D. Johnson8, 9, 10, Nilesh J. Samani11, 12, 31, Saonli Basu13, Martin Gögele2, Gail Davies5, Gordon D.O. Lowe14, David-Alexandre Tregouet7, Adrian Tan13, James S. Pankow1, Albert Tenesa15, 16, Daniel Levy9, Claudia B. Volpato2, Ann Rumley14, Alan J. Gow4, 5, Cosetta Minelli2, John W.G. Yarnell17, David J. Porteous4, 18, John M. Starr4, 19, John Gallacher20, Eric Boerwinkle21, Peter M. Visscher22, Peter P. Pramstaller2, 23, 24, Mary Cushman25, Valur Emilsson26, Andrew S. Plump27, Nena Matijevic28, Pierre-Emmanuel Morange29, Ian J. Deary4, 5, 30, Andrew A. Hicks2, 30 and Aaron R. Folsom1, 30
1 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA
2 Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy
3 Department of Experimental and Diagnostic Medicine, University of Ferrara, 44121 Ferrara, Italy
4 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
5 Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
6 School of Social and Community Medicine, University of Bristol, Bristol BS8 2PS, UK
7 INSERM UMR_S 937; Institute of Cardiometabolism and Nutrition (ICAN); Université Pierre et Marie Curie (UPMC, Paris 6); 75013 Paris, France
8 National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA
9 Center for Population Studies, National Heart, Lung and Blood Institute, Bethesda, MD 20824, USA
10 Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD 20824, USA
11 Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester LE3 9QP, UK
12 National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK
13 Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA
14 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK
15 Institute of Genetics and Molecular Medicine, Medical Research Council (MRC) Human Genetics Unit, Edinburgh EH4 2XU, UK
16 The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, UK
17 Epidemiology Research Group, Queen's University Belfast, Grosvenor Road, Belfast BT12 6BJ, UK
18 Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU, UK
19 Alzheimer Scotland Dementia Research Centre, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
20 Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK
21 Human Genetics Center and Human Genome Sequencing Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
22 Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane 4029, Australia
23 Department of Neurology, General Central Hospital, 39100 Bolzano, Italy
24 Department of Neurology, University of Lübeck, 23538 Lübeck, Germany
25 Departments of Medicine and Pathology, University of Vermont, Burlington, VT 05405, USA
26 Molecular Programming and Research Informatics, Merck & Co., Inc., Rahway, NJ 07065, USA
27 Department of Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ 07065, USA
28 Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
29 INSERM, UMR_S 1062, Aix-Marseille Université, 13385 Marseille, France
Activated partial thromboplastin time (aPTT) and prothrombin time (PT) are clinical tests commonly used to screen for coagulation-factor deficiencies. One genome-wide association study (GWAS) has been reported previously for aPTT, but no GWAS has been reported for PT. We conducted a GWAS and meta-analysis to identify genetic loci for aPTT and PT. The GWAS for aPTT was conducted in 9,240 individuals of European ancestry from the Atherosclerosis Risk in Communities (ARIC) study, and the GWAS for PT was conducted in 2,583 participants from the Genetic Study of Three Population Microisolates in South Tyrol (MICROS) and the Lothian Birth Cohorts (LBC) of 1921 and 1936. Replication was assessed in 1,041 to 3,467 individuals. For aPTT, previously reported associations with KNG1, HRG, F11, F12, and ABO were confirmed. A second independent association in ABO was identified and replicated (rs8176704, p = 4.26 × 10−24). Pooling the ARIC and replication data yielded two additional loci in F5 (rs6028, p = 3.22 × 10−9) and AGBL1 (rs2469184, p = 3.61 × 10−8). For PT, significant associations were identified and confirmed in F7 (rs561241, p = 3.71 × 10−56) and PROCR/EDEM2 (rs2295888, p = 5.25 × 10−13). Assessment of existing gene expression and coronary artery disease (CAD) databases identified associations of five of the GWAS loci with altered gene expression and two with CAD. In summary, eight genetic loci that account for ∼29% of the variance in aPTT and two loci that account for ∼14% of the variance in PT were detected and supported by functional data.