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Pulmonary Vasculitis Update / Review
Part 1: Clinical Features & Diagnosis
(Go to Part 2: Treatment and Prognosis)
Vasculitides are disorders of inflammation and necrosis of the blood vessel wall. Pulmonary vasculitides can present in multiple ways: with alveolar hemorrhage, infiltrates, nodules, cavities, or airway disease. They are categorized by the size of vessel involved (small, medium, and large), the underlying immunologic mechanism (pauci-immune, immune-complex mediated), and associated systemic disease. The nomenclature for pulmonary vasculitides has recently been revised by the 2012 International Chapel Hill Consensus Conference.
Although many forms of vasculitis have the potential to involve the lungs, the ANCA-associated vasculitides (AAVs) are a group of small-vessel vasculitides that commonly involve the respiratory tract and are the focus of a recent review in AJRCCM by Stephen Frankel and Marvin Schwartz. They include:
- Granulomatosis with polyangiitis (GPA), no longer called Wegener's granulomatosis because of the namesake's ties to the Nazi party
- Microscopic polyangiitis (MPA)
- Churg-Strauss Syndrome (CSS), a.k.a Eosinophilic Granulomatosis with Polyangiitis (EGPA)
- Idiopathic pauci-immune pulmonary capillaritis (IPIPC)
Epidemiology of Pulmonary Vasculitis
ANCA-associated vasculitis is rare (overall incidence 15-20 cases/million/year and prevalence 90-300 cases/million/year). Granulomatosis with polyangiitis is more common than microscopic polyangiitis in Europe & North America, while MPA appears to be more common than GPA in Japan & China. Churg-Strauss syndrome is quite rare, even less common than both GPA & MPA. There appears to be some element of genetic predisposition. Survival rates are decreased compared to the general population (RR 2.6) with 1, 2, and 5 year survival rates of 88, 85, and 78% overall. Poor prognostic factors include older age, greater disease activity, alveolar hemorrhage, cardiac involvement, and proteinase-3 positivity.
Clinical Presentation and Diagnosis of Pulmonary Vasculitis
Classification criteria for vasculitides have been developed by the American College of Rheumatology in 1990, and the Chapel Hill Consensus Conference in 1994, recently revised in 2012. However, the authors emphasize that these criteria are not meant to be used as diagnostic criteria, but rather that the diagnosis is made clinically through the integration of clinical, laboratory, radiographic, and pathology data.
Clinical scenarios that should prompt the consideration of ANCA-associated vasculitis include:
- Diffuse alveolar hemorrhage
- Tracheal or subglottic stenosis
- Pulmonary nodules and cavities
- Glomerulonephritis
- Destructive or ulcerating upper airway disease
- Mononeuritis multiplex
- Retroorbital mass
- Palpable purpura
- For Churg-Strauss: severe or refractory adult-onset asthma, peripheral eosinophilia, or eosinophilic pneumonia
ANCA-Associated Pulmonary Vasculitis: The Players
Granulomatosis with Polyangiitis (formerly Wegener's) commonly affects the upper respiratory tract (>85%) (otitis, hearing loss, sinusitis, epistaxis, nasal septal perforation, mastoiditis, and saddle nose deformity), lower respiratory tract (>80%) (cough, dyspnea, chest discomfort, hemoptysis, diffuse alveolar hemorrhage, pulmonary nodules, cavities, and infiltrates), and tracheobronchial tree (50-60%) (stenosis, ulceration).
Microscopic polyangiitis less commonly involves the upper respiratory tract (<15%) and lower respiratory tract (diffuse alveolar hemorrhage in up to 30%, but also infiltrates, pulmonary artery aneurysms, fibrosis, and airway disease).
Constitutional symptoms and extrapulmonary involvement (renal, cutaneous, musculoskeletal, ocular, cardiovascular, and peripheral nerves) occur in both granulomatous polyangiitis and microscopic polyangiitis. Glomerulonephritis and constitutional symptoms are particularly common in both, and are nearly the rule in microscopic polyangiitis.
Idiopathic pauci-immune pulmonary capillaritis: Think of IPIPC as "lung-limited microscopic polyangiitis" presenting as isolated diffuse alveolar hemorrhage.
Churg-Strauss Syndrome is characterized by the triad of asthma, eosinophilia, and vasculitis, described to occur in three phases of disease:
- Prodromal, allergic/atopic phase: manifest as asthma and rhinosinusitis
- Eosinophilic phase: tissue eosinophilic inflammation including eosinophilic pneumonia
- Vasculitic phase: palpable purpura and mononeuritis multiplex
In Churg-Strauss, asthma generally precedes vasculitis by an average of 7-8 years and is often severe and steroid-dependent. Upper airway disease (70-90%) is generally non-destructive (in contrast to GPA) manifest as chronic rhinosinusitis. Pulmonary infiltrates occur at some point in 70-90% and are patchy, bilateral, and migratory. Extrapulmonary manifestations are common, but cardiac involvement (30-50%) is responsible for half the mortality (cardiomyopathy, myocarditis, coronary aneurysms, conduction system disease, and sudden cardiac death).
Anti-Neutrophil Cytoplasmic Antibodies (ANCAs)
Anti-neutrophil cytoplasmic antibodies (ANCAs) are, as the AAV name suggests, characteristic of these diseases, but importantly, are not required for their diagnosis, if histopathology and clinical features are diagnostic. ANCAs are not only markers of disease but are also involved in pathogenesis by promoting neutrophil migration to, and degranulation in, vessel walls; and they may correlate (to some degree) with disease activity.
- c-ANCA = neutrophil cytoplasmic staining by indirect immunofluorescence. It is associated with antibodies specifically directed at proteinase 3 (PR 3) that are detected via ELISA. They are found in GPA with 85-90% sensitivity and 95% specificity when disease is generalized. Sensitivity is decreased when disease is limited (60%) or in remission (40%).
- p-ANCA = neutrophil perinuclear staining. It is commonly associated with antibodies specifically directed against myeloperoxidase (MPO), again detected by ELISA, which are associated with MPA and CSS. But the p-ANCA picture is less clear-cut than that of c-ANCA: 1) p-ANCA is associated with antibodies against other neutrophil antigens besides MPO and 2) p-ANCA/MPO are both less sensitive for MPA (50-75%) and CSS (35-50%) and less specific (may be found in other diseases).
Histopathology is usually required to confirm a pulmonary vasculitis diagnosis, especially considering the likely side effects of heavy immunosuppressive treatments and the need to rule out infection as the leading differential diagnosis. Don't forget that tissue specimens should be sent for microbiologic studies in addition to histopathology and immunofluorescence staining.
- The role of bronchoscopy is mainly to evaluate for diffuse alveolar hemorrhage, infection, and large airway complications. Transbronchial biopsies are usually not diagnostic, but endobronchial biopsies may be helpful in tracheobronchial disease.
- Skin and sinus biopsy are minimally invasive but lower yield.
- Renal biopsy and surgical lung biopsy are probably the highest yield.
With much thanks to:
Stephen K Frankel, Marvin I Schwartz. The Pulmonary Vasculidities. AJRCCM 2012;186:216-224.
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Welcome to the Emergency Medical Services for Children web site... Illinois EMSC is a collaborative program between the Illinois Department of Public Health and Loyola University Medical Center, aimed at improving pediatric emergency care and disaster preparedness within our state. Since 1994, the Illinois EMSC Advisory Board and several committees along with organizations and individuals within the EMS, pediatric and emergency management communities have worked to enhance and integrate pediatric education, standards, injury prevention and data initiatives into the Illinois EMS system. The goal of Illinois EMSC is to ensure that appropriate emergency medical care is available for ill and injured children at every point along the continuum of care.
What's New
IDPH Updates
State Pandemic Flu Plan (1141K)
Children and Facemasks handout (221K)
Use of Strategic National Stockpile (SNS) Ventilators in the Pediatric Patient. Instructional Guidelines with Training Scenarios (2nd Edition, 2010) (1.11MB)
Quick Set-Up Guides for the LP-10, LTV-1200 and the Uni-VENT Eagle Ventilators (186K)
Pediatric Seizures QI Project
Pediatric Diabetic Ketoacidosis (DKA) QI Project
Pediatric Mild Traumatic Head Injury QI Project
Regional QI Data Reporting Worksheet (3.6M)
Regional Pediatric Resource Directory (March 2012) (858K)
Continuing Education Tracking Tool for Hospital Personnel
PublicHealthLearning.com Education System User Guide (537K)
Illinois Poison Center Update!
Ron W. Lee, MD - Excellence in Pediatric Care Awards
The Illinois EMSC program is supported in part by funding from the Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau
Comments or suggestions? Contact Evelyn Lyons at email@example.com Illinois Emergency Medical Services for Children Loyola University Medical Center 2160 South First Avenue, Building 110-LL Maywood, Illinois 60153 (708) 327-EMSC (3672)
LUHS | Site Map | Comments | Webmaster
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Last Reviewed: Mar. 11, 2014

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Mansion Impossible The aim of the game is to make enough money buying and selling houses on the property market to buy the mansion. 10/6/2005 12:00:00 AM 505,972
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Students of the Month
DMS celebrates September Students of the Month: Tenaya Pfifer and Jack Jones, sixth grade; Claire Corbasson and Eli Farmer, seventh grade; and Emily Gonzalez and Jasper Carmichael, eighth grade. These students are being honored for their hard work, dedication, and kindness toward others.They make DMS a brighter place!
Fire safety
Garnet Mesa kindergarten students learn about fire safety from members of the Delta Fire Department. National Fire Prevention Week was Oct. 6-12.
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Ship, Accessories
If your little scalawag plays with the KidKraft Fun Explorers Pirate Playset long enough, maybe he'll learn how to find buried treasure for real so you can retire early. Big enough for your child to play with a friend (pirates never work alone, after all), this realistic ship opens up to reveal a detailed interior and comes with four molded pirates to man the stations. One pirate is holding a telescope to keep watch from the crow's nest, while the captain comes complete with a hook for a hand. Maybe he had a run-in with one of the two included sharks or was a little too careless with one of the two included cannons.
About KidKraft
KidKraft is a leading creator, manufacturer, and distributor of children's furniture, toy, gift and room accessory items. KidKraft's headquarters in Dallas, Texas, serves as the nerve center for the company's design, operations and distribution networks. With the company mission emphasizing quality, design, dependability and competitive pricing, KidKraft has consistently experienced double-digit growth. It's a name parents can trust for high-quality, safe, innovative children's toys and furniture.
30.7L x 12W x 26H inches
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Furnished Dollhouses , Toy Figure Playsets
Our products are shipped partially assembled. Assembly is easy and requires only common household tools. Furniture will be shipped with all necessary fasteners and easy-to-follow instructions. Carefully read the instructions and acquaint yourself with the wood parts, bolts and screw sizes before starting assembly of your furniture.
Have a question about this product? Ask a Product Expert! The answer will be emailed to you and then posted here.


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In 2010, eight years after Carson sold his trash company, an artist friend in the billboard industry mentioned that the massive ads, removed from their boards, made great drop cloths for painting. The wheels in Carson's head began to turn. He found a few billboards for sale, and put out feelers to friends in the agriculture and construction industries to see if they had any use for them. Thanks to his intervention, the billboards were reborn as tarps to cover hay and building materials. "We quickly ran out," says Carson, who was so encouraged that he started reaching out to more industries—from bowling pin manufacturers to poultry farmers—to inquire about purchasing hard-to-recycle items. Soon he'd founded Repurposed Materials, a company that turns would-be trash into valuable commodities. Torn-down billboards become pond liners, projection screens, even makeshift Slip 'N Slides. Synthetic turf from football fields is refashioned into cushioning for egg-laying chickens. And when one customer intuited that street-sweepers' brushes, stood on end, could be back scratchers for livestock, Carson sold two to the Bronx Zoo for its rhinoceros pen. "We're helping industries pool their knowledge," he says. "And our customers spend far less than they would buying similar products new." Carson now spends his days devouring trade magazines and visiting businesses to examine what they're throwing away. "This is my second foray into the waste stream of America," he says with a laugh. "Round one, I was burying things in the landfill. Round two, I'm trying to keep them out." Beauty the Eagle had her beak disfigured in 2005, when she was shot by a poacher. Set aside the grim symbolism of shooting an American Bald Eagle in the face, for a moment -- it's sad and brutal, yes. But what happened to Beauty is a lovely tonic. Jane Fink Cantwell, a raptor specialist at Idaho's Birds of Prey Northwest, has cared for Beauty all these years, through the hopes that her beak would grow back (it didn't) all the way to the near-unanimous call for euthanization (Cantwell refused). Beauty could not clean or feed herself, and so needed constant care and attention, and faced the possibility of never again living in the wild. Then, while giving a talk about Beauty, Cantwell met mechanical engineer Nate Calvin. Read the whole story in the Guardian for the amazing process Calvin used to fashion a prosthetic beak with a 3D printer.
The video below shows the process of fitting Beauty for her new beak. Watching it, especially the palpable nervousness of the poor confused bird, is a real nail-biter. But it worked, and Beauty was finally able clean and feed herself. Beauty and the Beak from Keith Bubach on Vimeo. While the Guardian reports that Beauty has had problems with keeping the beak attached, to me the best part of the story is that so many people have worked so hard to help the eagle reclaim her life. "It's a story about a Bald Eagle becoming a teacher," Cantwell says. And knowing that her process of rehabilitation is ongoing is a good reminder to all of us. Transformation may not happen overnight, but it's the process, not necessarily the result, that has the most to teach us. Saving Species on the Brink of Extinction A Woman Who Devoted Her Life to Wolves
Then in 1948, 2,741 acres of the Fresh Kills marshlands (kill is Old Dutch for "stream") were designated a landfill. Seven years later, Fresh Kills was the largest residential trash repository in the world—and the name Staten Island less synonymous with bucolic meadows than with an epic stench. But now Thoreau's "garden" is making a comeback—as Freshkills Park. In 2008 construction began on a 30-year master plan that calls for nature trails, a bird observatory, and canoeing. The city is also harvesting natural gas from the buried waste and using it to heat 22,000 homes (the waste is "capped" with an impermeable cover to prevent fumes from escaping). This summer the park's first completed section, a playground, is scheduled to open to the public; a pedestrian loop and the Owl Hollow Fields—which include soccer fields, lawns, and a LEED-certified rest area—will follow this fall. Red foxes and deer have already recolonized the upland forests, and park administrator Eloise Hirsh sees goldfinches on her way to work—evidence that "the land is healing itself," she says. "By turning this into something really beautiful, we want to help people be more thoughtful about what they throw out." It's one of the most humbling experiences a city-dweller can have: gardening. I'd volunteered to work in the community garden, so there I was on a Sunday morning, crouched in the dirt, hopping up every few minutes to find someone to ask, "Sorry, this is so embarrassing, but is this a weed? Is this a plant? Or a weed? Looks kind of planty? Wait, I mean weedy?" By the end of my two-hour-long shift, though, I was already seeing things differently: noticing a spriggy vine of weediness from across the garden patch; a rustling in the purple bushes I realized was a steady stream of visiting butterflies.
These are the moments we need, when you look at a thing long enough to see what it really is. As in these otherworldly shots of migrating butterflies on Environmental Graffiti: seeming at first to be a tree branch, or a smattering of leaves, the swarms of color reveal themselves to be instead bouquets of butterflies, masses of monarchs, and reason enough to look closely.
Visit Environmental Graffiti for more amazing images of these surreal butterfly swarms. Suggested listening while viewing:Muriel Rukeyser reading her poem "The Speaking Tree": "The trunk of the speaking tree looks like a tree-trunk / Until you look again...It calls your name." What else is calling our names, if only we would listen? What else could we see if we looked, looked again? Read More: Instant Inspiration: Photographs of Trees Breathing Space: Favorite Places on Earth
But in 2008, Perdue terminated her contract. Morison suspects this had something to do with the camera crews she'd allowed into her barns to shoot footage for the shocking documentary Food, Inc. It wasn't until 2011 that she and her husband bought 500 Rhode Island Red laying hens—and set about doing things their way. From the start, the hens were a revelation. They batted around Ping-Pong balls and chased each other to snatch pieces of lettuce, their favorite snack. While the industrial birds had been fragile and identical, the Reds were hardy and varied, with a stubborn resistance to disease. Perdue had demanded Morison use the company's proprietary feed, which she says routinely contained chemicals like arsenic (Perdue has said it stopped using arsenic in 2007). She fed her new birds grain, grasses, and clover to complement the worms they dug up on her 14 acres of pasture. Recently, Morison's farm was certified by Animal Welfare Approved. While she previously "despised" her work—in addition to her guilt over contributing to toxic runoff in the Chesapeake Bay, she says, "I just felt so bad for the chickens"—she reports that "these days I'm having way more fun."
In the past few decades, overfishing—coupled with climate change and pollution—has crushed our oceans' delicate ecosystems. In 2010 the United Nations estimated that 85 percent of the world's fish were overexploited or being fished at maximum levels. Which raises the question: What's a sushi lover to do? She could start by heading to Portland, Oregon, where Kristofor Lofgren, 30, is pioneering a guilt-free way to indulge in omega-3s. At Lofgren's acclaimed restaurant, Bamboo Sushi, you won't find overfished sushi-roll staples like bluefin tuna or unagi—but you might find sustainably caught Tasmanian ocean trout, horse mackerel, or even cod sperm. An inventive "Bamboo charcuterie plate" features "blood sausage" made from local Pacific albacore tuna. Lofgren's meticulous sourcing from only healthy populations has earned his restaurant the first Marine Stewardship Council certification in the United States. In his view, sustainability is more than a gimmick."Fish caught with care, in a more artisanal fashion"—e.g., using low-tech traditional methods like rods or a small net—"taste better," he says. "In a massive net, all the fish are struggling and stressed-out," conditions that raise the fishes' cortisol levels, which can make their meat tougher. Lofgren's hope is to lure customers with his sushi, then hook them through education. To that end, he's offering a whole shark on the menu—for adoption (the price: a $4,000 minimum donation to the University of Miami's marine conservation program, after which the restaurant will fly you to Florida to personally tag your toothy pet). "Being sustainable doesn't just mean sticking to seafood that's caught ethically and not overfished," Lofgren says. "Our goal is to turn our customers into ambassadors."
Four years ago, Zach Balle had a successful real estate career in Phoenix, which earned him an impressive paycheck but left him unfulfilled. "There was a sense that I'd made it," he says, "and yet I couldn't ignore this empty feeling in my stomach." After a colleague offered some unorthodox advice—"Book a flight to a country you've never been to"—Balle found himself in a small Guatemalan community where many children received their lessons outdoors. "If it rained, they didn't have class that day," says Balle, now 28. "I decided I wanted to build them a school—which was totally unrealistic. But I knew if I could figure out a way to include the townspeople in the project, we could make it happen." Armed with newfound inspiration, Balle quit his job and started researching his plan. He was dismayed to discover that even a simple structure would cost nearly $15,000 for supplies and labor. When he explained his dilemma to a contact in the Peace Corps, she told him about a method of construction she was using that transforms trash into building material. Balle decided to help her build a school in the Guatemalan community of Granados. His friend Heenal Rajani, 31, who had been casting about for a more meaningful endeavor, decided to help out as well. After local children collected empty soda bottles and stuffed them full of chip bags and candy wrappers, the resulting "eco-bricks" were placed between chicken wire panels and covered with cement to create the walls of the structure. Their two-room schoolhouse, completed in October 2009, used more than 5,000 plastic bottles and 2,053 pounds of trash, cost less than $6,000 to build, and now serves roughly 300 of Granados's students. In 2010 Balle, Rajani, and three other friends, including Joshua Talmon, 31, officially established the nonprofit Hug It Forward to fund more eco-brick schools across Central America; so far they've built 17 in Guatemala and one in El Salvador. The San Diego–based organization, which finances the school projects partially through eco-tourism trips (volunteers can sign up at ServeTheWorldToday.com), now publishes a free online manual to help others replicate their model elsewhere around the world. "Being a global citizen isn't about swooping in as a superhero," says Talmon. "There are more wins if we all work together."
I've lost count of how many phone cases have graciously given their lives in the line of duty. It's gotten so bad that even the sight of my naked iPhone makes me anxious. So after the latest case-killing incident (ahem, sidewalk spill), I knew I needed protection stat. Elvis & Kresse's stylish phone holders come with a not-so-obvious environmental bonus: They're fashioned from decommissioned British fire hoses that would otherwise be headed to the landfill. If stashing your phone in an old hose has visions of scratches dancing in your head, you can rest easy. "Our fire-hose pieces are lined with scrap parachute silk," explains designer Kresse Wesling, which makes the interior soft and scratch-proof. The cases are available in yellow and blue, but we prefer fire-engine red. ($45, voguevert.com)
So when Seventh Generation, masters of eco-friendly household cleaners, launched a new line of soaps, lotions, and body washes this summer, I was game to get my suds on. Like any packaging, you should skip the marketing hype on the front ("natural," "pure," and "healthy" aren't regulated claims) and flip to the backside. Here, the science is transparent and promising: No parabens, phthalates (hormone disrupters that have been linked to increased cancer risk), or synthetic fragrances. Equally noteworthy: This line is one of the first to qualify as a USDA Certified Biobased Product. The new seal discloses the percentage of materials that are made from renewable plant and marine elements versus petroleum products. All certified products must meet a threshold of 25 percent renewable resources, but Seventh Generation's mandarin-scented body wash, for instance, is 93 percent plant-based. Consider it a clean routine that leaves no residue of environmental guilt. ($4 to $8, seventhgeneration.com)
For the eco-minded eater, sushi can feel like a guilty pleasure: Much of the fish is imported from overseas or farmed unsustainably, and a study by the International Union for Conservation of Nature found that more than 40 species of fish could vanish in the next few years, due largely to overfishing. The next time you're seated at the sushi counter, you can check Monterey Bay Aquarium's handy mobile app for the best seafood choices (domestic Yellowfin tuna gets a green light, while Bluefin tuna is best avoided, both for the planet's sake and because of mercury concerns). Or you can skip the fish (and guilt) entirely and feast on vegetarian sushi. Guy Vaknin, the executive chef at Beyond Sushi, goes beyond the usual avocado-and-cucumber roll at his new restaurant, with creative combinations like asparagus and basil or kiwi and cucumber. We asked the former Hell's Kitchen contestant for tips on spotting worthy rolls at our local sushi joint or making your own at home (it's easier than you think!). "Like any dish, you eat with your eyes first," Vaknin says. "Green on green can look boring, but picking a roll that has layers of color gets you more excited to eat." The rest, he says, is all about balance: Every soft texture, like avocado, should be paired with something crunchy, like carrots or daikon radishes. And sweet ingredients work well with a bit of spice (Beyond Sushi's mango and pickled jalapeno roll is too tasty to share—sorry, tablemates). And like most green tips, there's no need to think of it as an all-or-nothing proposition: Swapping one of your standard rolls for a vegetarian option each time you're out can add up to a big, happy impact on our oceans. Advertisement
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How to log into Webmail
Where do I login?
Enter your domain name below and click the button to visit your webmail login page.
You will be asked for a username and password. The username will be your full email address (all lowercase). The password will be your email address password. Forgot your password?
What is Webmail?
There are several ways you can check your email. For example, you can setup a desktop email client such as Microsoft Outlook, Mac Mail or web-based clients such as Gmail to check your email. You can also check your email from your phone, such as an iPhone or an Android phone.
Like the previous examples, webmail is another tool you can use to send and receive email. Webmail is different because you can access it using a web browser. It doesn't require you to setup the software. You can simply log into webmail and begin to use it.
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Visit yourdomain.com/webmail
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User Name: Enter your full email address, all lower case
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You should now be logged in! Click on one of the three webmail clients and get started using your email!
Troubleshooting Webmail Problems:
I'm am not prompted for a username / password
If you are not asked to enter a username and password when visiting yourdomain.com/webmail, please instead try going to webmail.yourdomain.com.
This issue is usually caused by a firewall within your network blocking the webmail ports of 2095 and 2096. Using webmail.yourdomain.com allows you to access webmail over port 80, the normal port used for web traffic.
I forgot my password
If you forgot your email address' password, the easiest solution is to reset your email address password within cPanel and then try to log into webmail again.
I Don't Know whether I should click on SquirrelMail, Horde, or Roundcube!
After logging into webmail, you'll be presented with three options: Horde, Roundcube, and SquirrelMail. These three options are different webmail clients that can be used for sending and reading email. All of them show you your email, however each of them has their own look & feel as well as their own unique features.
The 3 available Webmail Clients |
SquirrelMail | Limited in features, however this allows you to quickly read and respond to email |
Horde | Has more functionality than SquirrelMail, however this can at times make the software slower and more "busy" |
Roundcube | Is the new kid on block, just recently introduced into cPanel. Feature wise it falls in between SquirrelMail and Horde, however it has a very clean look and feel to it, similar to a desktop client such as Mac Mail our Outlook |
What's Next?
In addition to webmail, there are a few other email features that can be used on our servers. You may be interested in learning more about:
- Email Forwarding - automatically forward emails to another email address
- Auto Responders - going on vacation? setup an auto respond to notify others when they email you that you are out of the office
- Spam Assassin - if you're having a problem with spam, start by setting up and configuring Spam Assassin
Please check the next article on Modifying your MX records. If you missed our previous article, please see the Creating an Email Account tutorial. For more information on this course please visit Using Email.
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2014-03-04 1:39 pm
need help, we can not enter the mail g****@i*******m.com. |
2014-03-04 2:48 pm
Staff Hello Deissy,
If you are having difficulty logging into your email account, you may want to reset the password. You can do this via the cPanel. Check out our article on Changing your email password for step by step instructions. Kindest Regards, Scott M |
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Wellmark inks ACO deal with Genesis Health System
Des Moines Register, June 7, 2012
Genesis Health System announced Tuesday that it has signed a contract with Wellmark Blue Cross Blue Shield to set up an accountable-care organization. Wellmark announced in April that it had signed similar contracts with Iowa Health System and Mercy Medical Center-Des Moines. The idea is gaining steam nationally, largely because of incentives from the federal health reform law. University Hospitals in Iowa City and Mercy Medical Center-Cedar Rapids, which are working together to form such an organization, signed on with Medicare. A Genesis spokesman said his system hopes to sign a similar contract with Medicare in the next few weeks.
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An effective site search tool is hugely important tool for ecommerce as it's a common way for shoppers to navigate sites and find products.
In fact up to 30% of visitors will use the site search tool and these tend to be highly motivated shoppers who know exactly what they're looking for.
The speed in which results are returned is very important, but there are also many other factors that influence the overall user experience and could be the difference between making a sale or losing a potential customer.
Read more...
by David Moth 13 November 2013 10:58am 5 comments
We all know the 4th quarter was a tough one for retailers. Despite the holidays, the global economic crisis had consumers pinching pennies and retailers were forced to discount heavily in an effort to entice them to spend.
Some online retailers such as Amazon.com reported 'record' holidays but many weren't quick to quantify what those 'records' meant to the bottom line and according to new numbers, Q4 2008 online sales in the United States were disappointing.
by Patricio Robles 19 February 2009 08:33am 0 comments


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Newtown tragedy strikes close to home for trauma counselor
Psychiatrist John Woodall has counseled trauma victims from Africa to Bosnia to New York City following the Sept. 11, 2001, World Trade Center attack.
But he never figured on doing the same in Newtown, Conn., where he and his wife live.
"It's heavily ironic," Woodall said Tuesday. "My wife and I just got back from Uganda working with child soldiers."
Woodall's specialty over the years has been helping to build resiliency among children exposed to traumatic situations.
"It's always someplace else," he said. "Never in my back yard."
Never until Friday, when a 20-year-old gunman blasted his way into the Sandy Hook Elementary School and killed 20 young children and 6 adults.
Woodall was working at a hospital in Holyoke, Mass., that day when his wife, Margo, paged him. She never does that, he said, so he knew something was wrong.
After speaking with her, he drove back to Newtown, listening to news reports as the extent of the massacre began to emerge.
After making a brief stop at the Newtown school superintendent's office to offer his help, Woodall drove to the fire station in Sandy Hook.
That's where the children who evacuated the school were led soon after the shootings. That's where the first responders from throughout the area gathered. The fire station is also across the street from the house where Margo Woodall once lived.


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There are no stupid questions; just obvious answers... or overlooked questions... or badly worded questions.
This quote is about questions
Search on Google Books to find citations of this quotation.
Adira Daniella Kessler is a young, new poet in the 21st century. began writing poetry in 6th grade when she was about 13 years old. She published her first book, Observations, in June of 2009, her senior year in high school. Adira uses her middle name, Daniella, as her pen-name.


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Bio / Lifestream / Archive
Free Research and Reports
- Dell Software Foglight APM 5.9: Introducing Big Data Repository/Reporting Supporting Web Analytics and User-Centric APM
- How Foglight Makes User Experience Management A Reality: Three Case Studies
- Application Performance Monitoring (APM) in the Age of Hybrid Cloud: Ten Key Findings by EMA
- Controlling and Managing Superuser Access
- How Traditional Firewalls Fail
Upcoming Events
Dark Reading Digital Magazine
In This Issue
- Secure The Cloud: Cloud security needn't be an oxymoron. Here's how to get it right.
- A Deeper Look At The Data: Find out what types of cloud apps are in use and what the top cloud computing threats are..
Tech Insight
Enterprise Vulnerabilities From DHS/US-CERT's National Vulnerability Database
CVE-2012-6290 (imagecms)
SQL injection vulnerability in ImageCMS before 4.2 allows remote authenticated administrators to execute arbitrary SQL commands via the q parameter to admin/admin_search/. NOTE: this can be leveraged using CSRF to allow remote unauthenticated attackers to execute arbitrary SQL commands.
Cross-site scripting (XSS) vulnerability in open-flash-chart.swf in Open Flash Chart (aka Open-Flash Chart), as used in the Pretty Link Lite plugin before 1.6.3 for WordPress, JNews (com_jnews) component 8.0.1 for Joomla!, and CiviCRM 3.1.0 through 4.2.9 and 4.3.0 through 4.3.3, allows remote attackers to inject arbitrary web script or HTML via the get-data parameter.
CVE-2013-1890 (owncloud)
Multiple cross-site scripting (XSS) vulnerabilities in ownCloud Server before 5.0.1 allow remote attackers to inject arbitrary web script or HTML via the (1) new_name parameter to apps/bookmarks/ajax/renameTag.php or (2) multiple unspecified parameters to unknown files in apps/contacts/ajax/.
CVE-2013-1893 (owncloud)
SQL injection vulnerability in addressbookprovider.php in ownCloud Server before 5.0.1 allows remote authenticated users to execute arbitrary SQL commands via unspecified vectors, related to the contacts application.
CVE-2013-2045 (owncloud)
SQL injection vulnerability in lib/db.php in ownCloud Server 5.0.x before 5.0.6 allows remote authenticated users to execute arbitrary SQL commands via unspecified vectors.


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Considering that i m very fond of baking, i feel i ve done injustice to the marble cake. You know, if it had a life, then it would probably threaten me at gun point. I ve been baking for the past 2 years. Oh yeah.. i did dabble in baking back in college. Which was always pandemonium and disaster. That s a different story. But somehow, in the past 2 years, it was never the era or an ocassion for the marble cake. I know what many of you all are thinking. I mean what a loser i am. I know..i know. Anyway, i finally did get around to baking the swirly cute marble cake day before yesterday. And it was a runaway success. I made the cake in the morning and it was gone before the evening even set in. If you want me to be a lil technical, then i can say the plate or rather the cake pan was clean during lunch. A dutiful thanks to Mr.P. Mind you, just dutiful and nothing more than that. I dont believe in thanking husbands. I only believe in making marble cakes for them to attain that effect.
Okie now, that i made the cake, i ve been having weird dreams all night long. I mean i ve been dreaming of cakes with pink ribbons engraved in them. I even saw a cake in the shape of an owl. Does someone know if its good omen to see cakes in dreams. I did google and dint get great answers. Oh! i do such baseless web loitering at times. That s like indulgence to me. Like only the last week, i was reading an article on names that ve been copyrighted. Ha... in true spirits of an inactive advocate. I mean now, i ve reached the point where i dont advocate law but i do advocate food. How fancy is that!! I wish we had food laws. But again that s wishful thinking. Back to the marble cake now. I ve seen some fantastic marble cakes in my life. For real and for virtual. Cant say i ve been lucky to eat all of them but looking would suffice for me. It still suffices for me to look and wonder what would have gone into making the cake.
Putting this cake together is as easy as a pie. No sweat cake is probably how the cake can be called in case someone wants to change the name. It s one of those recipes where you neednt keep track of anything from the eggs to the flour. Very little detail and a great cake. Now that s what i would call a trophy recipe. I mean seriously, arent we past the era of trophy wives? We should think more on cakes and bakes. Now, for the recipe. I mean finally... well i needed to ramble some :)
( I did not use a loaf pan. I had the audacity to use a square cake pan which was like 9"X9" and what i had was a cake which had risen and cracked in the middle. That s what happens to cakes which are baked in too large pans. You get worse cakes when you bake them in too small ones too!! So please use a loaf pan or use a smaller pan any shape but smaller. You can experiment with colors and flavors for the marble effect. Try a dash of mint with a shade of green or probably some fragrant rose with the lovely pink instead of the cocoa. I m going to try anyway. In case you have sour cream, use that volume by volume for the yogurt. The original recipe calls for sour cream but i experimented with yogurt. Kept my fingers crossed all along the baking but it worked like a charm. Feel free to use any yogurt, greek, low fat. just about any version.)
Prep Time: Under 20 mins
Cook Time: 38 to 40 mins
Makes one 9"X5" inch loaf
Source:Adapted from Martha Stewart S Marble Cake
What You Need?
Flour 1 and 3/4 cups
Butter 8 tbsp
Fresh Curd or yogurt 2/3 cup
Eggs 3
Sugar powdered 1 cup + 2 tbsp
Baking powder 2 tsp
Salt 1/2 tsp
Vanilla extract 1 tsp
Unsweetened cocoa powder 1/4 cup+1 tbsp
Butter for greasing
How To Make It?
Preheat the oven to 180 C.
Take a mixing bowl and place all the dry ingredients except the sugar and cocoa. Combine well.
In another mixing bowl,cream the sugar and butter until light and fluffy. Takes about 2 to 3 mins on high speed in an electric mixer.
Add the eggs one by one to the butter and whisk just until combined.
Add the vanilla and whisk for about 3 mins.
Now,mix in the flour and yogurt alternatively, beginning and ending with the flour.Do this by dividing the cake flour equally.
At this stage, you will have some flour or the batter around the bowl.
Scrape down and then whisk the batter for about 2 mins until well combined and free of lumps, scraping the batter if required at the same time.
Now divide the batter into 2/3 and 1/3 proportions.
Depending on your preferences, add the cocoa to either of the divided batter. In case you want more cocoa, add it to the larger portion or otherwise.
Combine well using the whisk.
Now is the fun part.
Grease your cake pan well.
Start adding the batter by the tablespoon or a ladle( who would know if you do it with a ladle or a tbsp?)
Alternate with the two batters until you ve finished up with the whole lot.
Using a knife, draw a cross through the middle of the cake pan.
Dont overdo this or you will land up with a not very marble cake.
Once done, drop the cake tin on the counter top gently once or twice.
Bake in a preheated oven at 180 C for 35 to 40 mins or until a skewer inserted comes out clean.
Remove from the oven and let it cool in the pan for about 10 mins.
Invert and slice the cake as you desire.
And voila!! you have a marble cake all ready to be gobbled up with a glass of chilled milk. That s what i did anyway.
Sending this to Bake fest hosted by Sumee forVardhini


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Cedar Rapids Weather
Former Cyclone Sharpshooter McGee ArrestedBy Rob Gray, Reporter
AMES, Iowa - Former Iowa State basketball player and reigning Big 12 Conference Sixth Man of the Year Tyrus McGee Tuesday was charged with fourth degree theft.
ISU police investigations captain Aaron DeLashmutt said Wednesday McGee admitted to taking about $220 that did not belong to him. Video surveillance at the Hawthorn Market and Cafe captured images of McGee extracting the money from an unattended wallet. DeLashmutt said McGee told police he spent about $60 on groceries and gave money to friends, as well. McGee then turned over the remaining cash, DeLashmutt said. Fourth degree theft is a serious misdemeanor under Iowa law. McGee, from Stringtown, Okla., made an NCAA Division I-leading 46.4 percent of his 3-point shots in 2012-13 — his senior season as a Cyclone. Conversation GuidelinesBe KindDon't use abusive, offensive, threatening, racist, vulgar or sexually-oriented language. Share KnowledgeBe truthful. Share what you know and what you are passionate about. Stay focusedPromote lively and healthy debate. Stay on topic. Ask questions and give feedback on the story's topic. Report TroubleHelp us maintain a quality comment section by reporting comments that are offensive. If you see a comment that is offensive, or you feel violates our guidelines, simply click on the "x" to the far right of the comment to report it. read the full guidelines here » Commenting will be disabled on stories dealing with the following subject matter: Crime, sexual abuse, property fires, automobile accidents, Amber Alerts, Operation Quickfinds and suicides. |
What's On KCRG |


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Community Opinion & Comments
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I can see Mr. Lars still thinking through his selection for this particular Friendly Match. Although Nigeria did not perform well, the good news is that the players Nigeria did not let any goal behind the net. Saudi Arabia got two goals against Spain, although one must say Spain was caught sleeping to have allowed two goals. Anyway, Saudi Arabia isn't a team to underestimate their game style. With only two friendly matches in for the Super Eagles, Nigeria has not come out victorious in any nor has Nigeria lost a game. Therefore, the build up by Mr. Lars isn't to be criticized faultily.
The highlight was concentrating the Number 24 player of Saudi Arabia. He is very talented and skillful.
hope mikel, osaze and yakubu will play better in the wc because this was a dissapointing performance
0 - 0


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Length: | 11.25 in. |
Weight: | 7 lbs. |
Amperage: | 7.5 |
Anvil Type: | Pin Detent |
Drive Size: | 1/2-in |
Drive Type: | Square |
Handle Style: | Mid-Handle |
Power Type: | Electric |
Reversible: | Yes |
Shipping Weight: | 7.95 lbs. |
Torque: | 345 ft-lbs. |
Trigger: | Single Speed Rocker Switch |
Voltage: | 120V |
Reviewed by 3 customers
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Best Uses
Comments about 7.5 Amp 1/2-in Impact Wrench:
Use it for handyman projects driving lags and nuts for deck work and landscaping. The power is great when my 18v, 1/4 in Dewalt impact driver just isn't enough for bigger driving. I plan on using it for rotating vehicles tires as well. I like the lower cost of reconditioned tools I don't plan on using on a regular basis. Dewalt stands behind even the reconditioned tools. My only dislike is needing to use a nail to depress the chuck ball so I can change sockets.
Best Uses
Comments about 7.5 Amp 1/2-in Impact Wrench:
Used mainly for rotating tires and other car work. Performs excellent. Would have been nice to have a case included.
Comments about 7.5 Amp 1/2-in Impact Wrench:
I bought this because of the torque rating.
Wanted to use it on wheel lugs;
Displaying reviews 1-3
Condition: | New | Factory Reconditioned |
Features: | Same | Same |
Specs: | Same | Same |
Includes: | 1/2-in 2,100 RPM 7.5 Amp Impact Wrench - DW292 | 1/2-in 2,100 RPM 7.5 Amp Impact Wrench - DW292R |
Availability: | In Stock | Out of Stock |
Warranty: | 3 Year Limited | 1 Year Limited |
One-Year Limited Warranty. DEWALT will repair, without charge, any defects due to faulty materials or workmanship for one year from the date of purchase. This warranty does not cover part failure due to normal wear or tool abuse. For further detail of warranty coverage and warranty repair information, visit www.dewalt.com or call 1-800-4-DEWALT (1-800-433-9258). This warranty does not apply to accessories or damage caused where repairs have been made or attempted by others. This warranty gives you specific legal rights and you may have other rights which vary in certain states or provinces.


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Fresno St beaten again by Boise St 20-10
BOISE, Idaho (AP) -- There were moments when Phillip Thomas thought Fresno State would rally and... More
- TODD DVORAK Associated Press
BOISE, Idaho (AP) -- There were moments when Phillip Thomas thought Fresno State would rally and... More
SAN MARTIN, Calif. (AP) -- John Mallinger remained in position for his first PGA Tour victory,... More
CONWAY, S.C. (AP) -- Miguel Maysonet ran for a career-high 233 yards and two touchdowns to propel... More
BOZEMAN, Mont. (AP) -- Dylan Zylstra blocked a punt early in the fourth quarter that Evan Day... More
STATESBORO, Ga. (AP) -- Dominique Swope rushed for two touchdowns and 137 yards to lead the... More
PROVO, Utah (AP) -- Even though BYU's vaunted defense struggled for the first time this season,... More
BOWLING GREEN, Ohio (AP) -- Booboo Gates scored on a 37-yard interception return and Matt Schilz... More
FAYETTEVILLE, Ark. (AP) -- Kentucky's game at Arkansas has resumed after an hour and six-minute... More
HAMMOND, La. (AP) -- Xavier Roberson ran for touchdowns of 34 and 11 yards and Seth Sebastian... More
ANN ARBOR, Mich. (AP) -- Illinois has lost five games by an average of more than four... More
LAWRENCE, Kan. (AP) -- J.W. Walsh threw for 255 yards and accounted for two touchdowns, and... More
GREENVILLE, N.C. (AP) -- Shane Carden tossed five touchdowns and threw for 308 yards as East... More
SOUTH BEND, Ind. (AP) -- Notre Dame knew what was coming. Stanford doesn't get cute inches from... More
GRAND FORKS, N.D. (AP) -- Cary Grossart threw four touchdown passes and Northern Arizona won its... More
HOUSTON (AP) -- Quarterback Taylor McHargue ran for two touchdowns and Turner Petersen added... More
RICHMOND, Ky. (AP) -- Senior quarterback T.J. Pryor broke two school passing records while... More
LOUISVILLE, Ky. (AP) -- There's a time and place for light shows, videos and thumping music. Just... More
CLINTON, S.C. (AP) -- Aldreakis Allen and Sirchauncey Holloway combined for five rushing... More
KUALA LUMPUR, Malaysia (AP) -- Defending champion Na Yeon Choi maintained a two-shot lead in the... More
MONTGOMERY, Ala. (AP) -- Ryan Deising's 39-yard field goal as time expired gave Jackson State a... More
EAST HARTFORD, Conn. (AP) -- Brandon McManus kicked a 29-yard field goal in overtime and Temple,... More
ST. LOUIS (AP) -- Eddie Lacy and T.J. Yeldon gave top-ranked Alabama a pair of 100-yard rushers... More
SAN JOSE, Calif. (AP) -- Kerwy Williams scored three touchdowns on the ground, Chuckie Keeton... More
FAYETTEVILLE, Ark. (AP) -- Kentucky's game at Arkansas has been delayed due to lightning. The... More
CHARLESTON, S.C. (AP) -- Rickey Anderson scored from 11 yards on the first play of the fourth... More


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Featured Business Titles
All Business Titles
Run for Elected Officeand Win
This book presents everything you need to know to run forand win!elected office. -
Rethinking the Internet of Things
In the coming decade, billions of simple devices must be connected to the emerging Internet of Things. Todays networking protocols are too expensive and inefficient for this task. This book describes a simpler and scalable architecture that will be used to create big data from billions of small data points in the Internet of Things.
Reputation, Stock Price, and You
Reputation, Stock Price, and You: Why the Market Rewards Some Companies and Punishes Others gives you insight into how reputation affects stock price and company value, and how you can use that insight to manage more wisely, oversee operations more effectively, operate more profitably, and invest more successfully. -
Reinventing Financial Regulation
Combining Avinash Persaud's deep expertise in the academic, private sector, and public policy realms, Reinventing Financial Regulation is more than just an urgent call to fix our profoundly troubled and damaged financial markets; it is a blueprint for an ultimately effective financial regulation system that could very well save the future of finance.
- Regulation A(+): How the JOBS Act Creates Opportunities for Entrepreneurs and Investors explains how emerging growth companies can raise more money more easily under new provisions in the recently enacted JOBS Act.
- Reasonably Simple Economics shows readers how to think like an economist and better understand--and succeed in--the world around them.
Protect Your Wealth from the Ravages of Inflation
Protect Your Wealth from the Ravages of Inflation is for people who have financial assets to protect in an unpredictable, inflationary environment. It is a no-nonsense, straightforward guide that will help readers protect their wealth and give it a better chance to grow in real, inflation-adjusted terms. - Learn the business thinking behind financial modeling and execute what you know effectively using Microsoft Excel.
Preventing Good People From Doing Bad Things
With all of the threats to their security, many corporations have learned the hard way that threats can come from both the outside and from within. This is a book promoting the concept of least privilege. It will give readers information on protecting virtual environments, policy, compliance and more to keep good people from doing bad things. - Power Plays: Energy Options in the Age of Peak Oil is designed to help laypeopleincluding businesspeople, policy makers, and investorssort through the hype and misinformation to understand what really matters in energy, how it affects them, and what the future will bring.
- Plan Your Own Estate takes a straightforward and engaging you-oriented approach to dealing with one of lifes certainties--death. It puts you in control of how your money and your values will be passed on to family, friends, and organizations.
- In Plan Your Financial Future, financial planner and educator Keith Fevurly describes a novel way of analyzing and putting into place the personal financial planning process by teaching readers how to protect themselves, their family and their property; accumulate wealth; defend their accumulated wealth; and distribute their accumulated wealth.


text:
MECH-4533 Vibration Theory & Appl
Free and forced vibrations of multiple degree of freedom mechanical and structural systems with various types of damping. Theory of vibration isolation, design of vibration absorbers, harmonic and nonharmonic disturbances and shock spectrums. Theory of vibration measuring instruments. Introduction to dynamic finite element methods. Lecture - 3 hours. This course is normally offered in the spring semester.
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If a multitude of remotes is starting to take over your coffee table, maybe it's time you simplified things with a universal remote control. The Philips Prestigo SRU8015 is a slick model that could be your number one. Priced at around £70, it comes with a library of built-in codes and can take command of up to 15 pieces of kit at any one time.
Unlike other smart remotes, such as those in Logitech's Harmony range, you don't have to hook the Prestigo up to a computer to set it up to control your devices. Instead, it has a large built-in database of codes.
Programming the remote really is as easy as slicing warm butter. You just use the iPod-style mechanical scroll wheel to select the type of device you want to control, choose the manufacturer's name from a list and then point it at your piece of kit and hold down a button until the device turns off. We had it set up to control a TV, cable box, satellite receiver, digital media player and Xbox 360 in a matter of minutes.
The Prestigo also acts as a learning remote so if you have any devices that aren't held in remote's database you can use your existing controller to program in the required codes.
The remote is long and sleek and has a surprisingly high resolution colour screen at the top where you cycle through the devices you want to control. Thanks to a cut away on the underside of the remote it feels very comfortable to hold and the well laid-out buttons are backlit so they're easy to read when you've got the lights dimmed for a spot of at-home cinema.
As well as teaching the remote to control individual devices you can also set up what Philips calls 'Activities'. These are simple macros that run in sequence. For example, you can quite easily program a 'Watch Cable TV' activity that instructs the remote to turn on your TV, surround sound decoder and cable box all by just pressing a single button.
Perhaps the remote's coolest feature is the Favourites mode. The Prestigo has a large onboard database of channel logos that you can assign to individual channel numbers. Once the numbers are assigned you can choose the channel you want to watch by hitting the 'Fav' button and then scrolling through the list of colourful logos. It's definitely a feature that will impress your mates.
Our biggest bugbear with this remote is the way Philips has positioned the scroll wheel on the outside of the traditional four way direction pad. The wheel is used to select the device you want to control, while the pad is used to move though the menus on the selected device. However, it's too easy to move the wheel slightly while trying to navigate menus with the pad. The result is that the remote suddenly swaps to a controlling a different device midway through an action that you were trying to perform.
Also, although the Prestigo is initially very easy to set up, we did find that we had to tweak a number of the presets to improve the buttons layouts and make them more to intuitive to use with our kit.
Another issue is that unlike some rivals, this controller can't be connected to a computer, so there's no way to add new channel logos for the Favourite's feature -- it doesn't include Virgin One, for example -- or to download new button assignments for the latest kit.
There's a lot to like about the Prestigo. We love the way it's so easy to initially set up and the sharp, colour screen and slick design mean it looks really classy. There are also some seriously cool features like the Favourites mode. However, it can take some time to get used to the combined scroll wheel and direction pad layout and you may find that you have to tweak many of the presets to get them to work better with your kit.
Edited by Jason Jenkins
Additional editing by Shannon Doubleday


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Rolex Names Le Mans Champ Tom Kristensen New Brand Ambassador
Filed under: Timepieces / Watches, Luxury Cars & Autos, Sports
Danish racecar driver Tom Kristensen, winner of Le Mans a record-breaking eight times, has been named as Rolex's newest ambassador following the longstanding practice of the famed Swiss watch brand's association with world-class athletes. Rolex has never before made an official announcement naming an ambassador, but Danish Rolex retailer Klarlund persuaded them to make an exception this time. "Not only are we proud of Tom Kristensen's victories, we are also very proud hosts of such a rare and special occasion," Klarlund managing director Stig Andersen told Worldtempus after presenting the new ambassador with a Rolex Daytona Everose, one of Rolex's gifts to its new sporting face. Kristensen will also receive a Rolex Milgauss outfitted with a green sapphire crystal.
[via LuxuryLaunches]


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Today will be a busy day for lymphoma doctors. An impressive array of new targets, new agents, and new monoclonal antibodies, as well as studies of PET imaging and novel combination strategies will be presented at the lymphoma oral sessions today. In all, there will be 11 separate oral sessions from 7:00 a.m. to 7:15 p.m. (not including CLL), covering B- and T-cell biology, prognosis, imaging, therapy, new agents, and preclinical studies.
The day starts early with competing sessions at 7:00 a.m. titled New and Emerging Biologic Therapies (Room 3001-3003-3005 – West) and Targeted Therapies and New Agents in Lymphoma (Room 2005-2007-2018-2020 – West). These include presentations of immune-mediated treatments of lymphoma, as well as studies of new agents, new combinations, and novel monoclonal antibodies. The role of consolidation with radiotherapy remains controversial in lymphoma, as does the value of interim PET scanning, and prospective studies from the United Kingdom, United States, and Germany evaluating the utility of both of these strategies will be presented later in the morning in the Hodgkin Lymphoma – Interim PET in Lymphoma session (11:00 a.m. in Room 2005-2007-2018-2020 – West). Interestingly, in a presentation earlier in the morning, PET scanning is used as a correlative study to demonstrate proof of mechanism of a cyclin D-dependent kinase inhibitor in mantle-cell lymphoma in a study by Dr. John P. Leonard (abstract #264).
Later, in the Diffuse Large B-cell Lymphoma: Biology and Prognosis session (1:30 p.m. in Room 3001-3003-3005 – West), new molecular prognostic factors are presented. This includes an interesting study by Dr. Davide Rossi (abstract #480) of the impact of host pharmacogenetic background (using candidate single nucleotide polymorphisms) and its association with clinical outcomes (toxicity and event-free survival) after R-CHOP chemotherapy for diffuse large B-cell lymphoma. In the afternoon, Clinical Studies in Lymphoma (Room 120-125 – North) will include presentations on new treatment strategies and new prognostic markers, while in DLBCL and Other NHL: Novel Therapeutic Targets and Approaches, preclinical studies of new agents will be presented. Both of the latter sessions start at 3:30 p.m. in Room 3006-3008 – West. Finally, studies of B-cell biology are presented later in the day, with Low Grade B-Cell Lymphoma: Biology, at 3:30 p.m. (Room 3001-3003-3005 – West), followed by B-Cell Biology at 6:00 p.m. (Room 2006-2008 – West).
The breadth of the new therapies being presented is both fascinating and astounding. They include immunotherapeutic strategies ranging from the use of autologous cytotoxic T-lymphocytes targeting EBV latent membrane proteins in EBV+ lymphoma (Bollard, et al., abstract #230) to reduction in immunosuppression as treatment for post-transplant lymphoproliferative disorders (Cheema, et al., abstract #229). Results of the strategy of lymphoma-derived idiotype (Id) vaccination is also being presented, including both positive trials (e.g., early-phase study of Id expressed as a recombinant Fab fragment) and negative trials (e.g., phase III placebo-controlled study of adjuvant mitumprotimut-T (Id-KLH and GM-CSF).
There is continued great interest in the development of new or "optimized" monoclonal antibodies in lymphoma, including radio-labeled anti-CD25 (Y90-labeled daclizumab), SGN-30 (anti-CD30), GA101 (humanized and glyco-engineered anti-CD20), and the anti-CD22 immunotoxin inotuzumab ozogamicin in combination with rituximab. Encouraging responses are also noted with blinotumomab, a BiTE antibody targeting CD19.
New targeted kinase inhibitors being presented include BI 2536, targeting the Polo-like kinase 1, and fostamatinib disodium (targeting the spleen tyrosine kinase SYK), which was presented at the Plenary Session yesterday.
Presentations in peripheral T-cell lymphoma include a multicenter trial of pralatrexate (with B12 and folic acid), reporting impressive activity, and a study of romidepsin (a pan-HDAC inhibitor), reported to show clinical benefit in refractory cutaneous T-cell lymphoma. The use of a novel intensive treatment strategy for enteropathy-associated T-cell lymphoma (including autologous stem cell transplantation) suggests improved survival in a sequential study from the Scotland & Newcastle Lymphoma Group.
I know it will be a great day, and it will certainly be a long day. After the oral sessions, you should attend the lymphoma poster sessions from 5:30 to 7:30 p.m. If I see you there and you can still utter the word "lymphoma" coherently, I will congratulate you personally!
Dr. Foran indicated no relevant conflicts of interest.
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Here it is Christmas Eve, already! Thanks for a another great year! Merry Christmas and a Happy New Year, wishing for a prosperous 2014 for you and your family! Thanks Buddy! Ron
Would you like to be buddies?
Thanks buddy! My brother lives down in Powell, KnoxGasPriceSpy, so if you see him, say Hi! I also have a sister that lives in Strawberry Plains and my mother is in a nursing home in Jefferson City! They are all transplants from upstate NY many years ago! lol! How quickly the past 68 years have passed, through thick and thin, it has been interesting! The results, I made it through my growing up years, barely! Served 21 years in the US Navy, traveled all over the world, for work, not pleasure! Got married when I was 22, I've been married 45 years, 6 sons, 3 daughters, 16 grandchildren, and 3 great-grandchildren! I've worked more than 50 years of the last 68 years and completely retired in 2010, but still have lots of things to do! lol! I know I don't have as many years ahead as those that are much younger and it is tough trying to stay healthy when a person gets to their later years, but we'll keep marching on! lol! Thanks for being here! Have a nice week! Ron
Keep going like a PRO Knoxville GasBuddy! We are all here helping others save on gas and we help even more when we post gas prices each day! Posting regularly each day can help each of us see where the best gas deals are located, it's nice seeing GBs come back to post gas prices as often as they can and it's really a big help to the tens of thousands of GBs and others, especially those that travel! It takes a lot of dedication and persistence to climb the GasBuddy ladder to each level, but thousands of GBs do it each day! Many GasBuddies average more than 975 points each day as you have been doing, getting to their next level much sooner! But 90% or more of new GBs will not make it to their 1st red car (1M points), most of the 8,000,000 GBs quit before they even get close, but keep going, you can do it, you're getting closer each day! It's wonderful seeing you come back each and every day for the past 12 days! Thanks buddy! Ron
Thanks for becoming my buddy! Have a nice week and Merry Christmas, a Happy New Year, and a prosperous 2013 to you and your family! Thanks for a another great year! Ron
Hi! Thanks for posting on my page! Have a great weekend!! :-)


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Blog Love! The Comic's Comic "Meet Me In New York: Emily Heller"
Sean L. McCarthy interviews Heller on the finer things in life: pizza, Steve Wozinak, and of course, the harrowing distant future.
[Photo by Mindy Tucker]
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Phoning it in Video
Phoning it in Video Transcript
-Hi, I'm Molly Wood and welcome to the buzz report to show about the tech news that everyone is talking about. I'm actually on vacation right now, so let's get right to it. First up, the gadget of the week. The gadget of the week is the Verizon iPhone. Yap, this bad boy officially went on sale this week after a little preordered blitz last week. Now, as you know, the Verizon iPhone is basically the same as the AT&T iPhone. The major difference is a slightly tweet antenna design and then of course, the ability for it to act as a Wi-Fi hotspot for an additional fee. Real question now? How many AT&T users will switch to Verizon, how many Verizon users will switch to iPhone, and how many bar fights will be started by iPhone owners trying to prove that they have a way more awesome network than the other guy? Alright, that's probably only gonna happen in nerd town. And now for the news, there were so much tech news this week and I'm not even at work. There was the Verizon iPhone launch, the big life changing Sprint events, the WebOS tablet and junk. And you know what? May be you guys should just roll some clips while I work on my tan. -Hey, everyone, I'm Bonnie Cha, senior editor at cnet.com and we're here at a very special event in New York where Sprint just unveiled the Kyocera Echo. This is the first dual touchscreen device and it'll be available later this spring. As you can see, it has 2 screens. It's 3.5 inches diagonally and both WVGA resolution. They've optimized the software here so you can use applications in standard mode, which is just that single screen. There is also a tablet mode. The feature that I'm most excited about is the Simul-Task mode, which allows you to use 2 different applications on the screen. At launched, it'll only be available on 7 applications, mostly the main 4 features like messaging, photo gallery, browser. It's a pretty cool feature that I think will take multitasking to a new level. -This is the HP TouchPad. The TouchPad not only looks great, it feels great in the hands, weighs a little more than a pound and a half and it's just over 13.5 mm thick. The screen is beautiful, bright, and viewable from any angle and has Beats Audio technology for unparalleled music playback. You can access and edit your Microsoft documents since TouchPad comes bundled with Quickoffice and you can collaborate with colleagues using Google Docs, Dropbox and Box.net. The TouchPad supports VPN to connect to corporate networks and working with Skype and others to enable video calling. If you need to print something, and who doesn't, TouchPad is compatible with HP's industry-leading printing solutions and let you send documents wirelessly to tens of millions of HP's network and wireless printers. -Hey guys, this is Eric Franklin from CNET. We're here at the HP WebOS events. What I have right here, the-- the Veer. Let me give you an idea of how small it is. This is my iPhone 4 right here, right next to it, and it's, as you can see about 2/3 of size. One of the new features of WebOS 2.0 is just tight. So, basically, if you have a card up and you just start typing, you'll get a couple of options and like I just typed rats just as a random and you can even use that text to go to Google maps, go to Wikipedia, to do more research on it, or you can like go to Facebook and just post whatever you just typed. It just feels really small. It has a camera on the back. It's really light. I feel like people who don't really like larger phones are probably gonna be really be in to it. We don't know anything about pricing yet or anything about confirmed dates so far, but stay tune to CNET and we'll be bringing you more news on the VEER. -Meet the Pre 3. The Pre 3 is a full size, fully equipped office on the go. It's a thin portrait slider with the largest QWERTY keyboard we've put on any WebOS phone to date. So, it easily handles business class e-mail. It has a Gesture area for navigation and a gorgeous 3.6-inch WVGA display. Pre 3 has full multimedia capability including a 5-megapixel camera that chose HD video with video stabilization and a forward-facing camera for video calling. -I'm Maggie Reardon with cnet.com and I'm here at the Apple store on 5th Avenue where Verizon and Apple are about to kick off the Verizon iPhone. The crowds here are not quite what they are for a normal iPhone launch. It's 6:50 here in Manhattan and there are 7 people in line. The phone actually goes on sale at 7:00 o'clock this morning and the temperatures are in the teens, snow is on the grounds, and people are staying home. -Man, somebody has been super busy this week. I'm glad it's not me. You could see the full coverage of all that stuff over at cnettv.com. That's the buzz report for this week everyone. I'm Molly Wood. See you next week.
Related Videos
This week on the CNET Tech Review: Verizon's iPhone launch gets a chilly reception; HP debuts TouchPad tablet running WebOS; and Sprint's Kyocera Echo doubles down on touch screens.
iPhone saves lives...literally
This week in Buzz, the amazing story of an iPhone that saved its owner's life, cute puppies are back, and yeah, fine, whatever, Apple tablet.
Frigid temps temper Verizon iPhone launch
HP touts over 50 new features in WebOS 2.1 and unveils its TouchPad tablet, Pre 3 smartphone, and diminutive Veer smartphone. Meanwhile, freezing cold in NYC makes for an unusually timid iPhone launch for Verizon.
Ep. 1564: Molly's new iPhone 4 is no Halloween trick
In the tech news this week, Stephen and Brian bust me for buying an iPhone 4 on eBay to tide me over until there's a phone I really want--or until my Verizon contract is up. Nicole Lee joins us to talk about Nokia and Microsoft's new baby, the Lumia 800, and Sony's plans to get serious about making smart phones. Plus, stock advice from the gang, the coming nightmare that is the Stop Internet Piracy Act, and Computer Love.
Ep. 1290: Android says, Talk to me, baby
Google launches new voice control for Android. Apple breaks over-the-air Jailbreaking. Spock's coffin has us spinning in our graves. And also, Rafe needs a new TV. Yeah, it's kind of a slow news day.
Palm and Sprint are ready to launch their second WebOS phone. See what the Palm Pixi has to offer in our First Look video.
Ep. 1423: No joy in Zynga-ville
Zynga tries to trademark the use of -ville as a suffix in everything from games (including the games it shamelessly ripped off) to clothing stores. Won't someone stop the madness? Please? Also, Goldman Sachs states from its highly compromised position that Facebook could be a credible threat to Netflix, and credulous reporters and shareholders eat it up. Plus, HP makes a SERIOUS move: putting WebOS on all new PCs. --Molly
In buzz this week, there's a possible corroboration of a Verizon iPhone; Twitter wants to make money for real this time; and a Molly Rant in video form.
Ep. 1148: Verizon cuts off alleged illegal downloaders
Breaking news during the show has Verizon admitting to cutting off the Internet access of people accused of illegal downloading. But hey, they don't throttle,they say. Great! Except for cutting off people is really an extreme from of throttling. And also, Verizon isn't getting proof for this, just accusations. The problems with this policy are immeasurable and we discuss them. Oh and Bing may oust Google on the iPhone.
Ep: 1385: It's so hard to good-bye to H.264
We dissect Google's decision to drop H.264 support from Chrome and go with WebM, we mop up a little bit of the Verizon iPhone news, and more importantly, we eventually get this show on the road after yet another tech disaster. Also, and this is very important, people, the next version of Android will not be called Ice Cream. It's Ice Cream Sandwich, people. Keep up. --Molly


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5 Chris Anderson |
Coach White to talk LA Tech Hoops
LA Tech will be the No. 1 seed in the C-USA Tournament
LA Tech defeated Rice, 70-48
Head coach Michael White post-game
Tipoff is set for 7 p.m.
Bulldogs hold off Blazers for 67-58 road win
LA Tech defeated MT, 55-39, to move into a tie for first place in C-USA.
LA Tech versus North Texas 2/8/14
LA Tech versus Tulsa 2/6/14
LA Tech versus Marshall 1/25/14
2012-13: Played in 33 games while starting 10, including eight straight from 1/26-2/28 ... Totaled 154 points while scoring 4.6 points per game in just 14.8 minutes of action ... Registered three double-digit scoring games and led the team twice in scoring in a single game ... Also averaged 3.6 rebounds and 0.5 blocks ... Recorded his first double-digit scoring performance at UTSA (1/12) with 10 points ... Had another strong outing versus UTSA (2/7) at home, scoring 11 points on a career-high 5-of-10 shooting to go along with seven rebounds ... Played a career-high 30 minutes the next game against Texas State (2/9) when he pulled down a career-high 13 rebounds ... Had his best game as a Bulldog at Seattle (2/14) when he scored a team-high 15 points to go along with a career-high four key steals ... Nearly recorded a double-double versus Central Baptist (2/20) after tallying nine points and nine rebounds.
Weatherford College: Averaged 14 points, five rebounds, three assists and two steals per game ... As a freshman, averaged 14.5 points and 6.8 rebounds while shooting 55.5 percent from the field ... Earned all-conference honors in the North Texas Junior College Conference his freshman and sophomore seasons ... Helped lead the Coyotes to the Region V tournament.
High School: Lettered at Reeths-Puffer High School where he was rated as the 67th best small forward on ESPN's national ranking of high school recruits ... Averaged 19 points and 13 rebounds per game his junior year ... Earned honorable mention Class 1A all-state honors and was a member of the Muskegon Chronicle's Class A-B All-Area team.
Personal: Chris Anderson ... Chose Louisiana Tech over Central Michigan, Kent State, San Diego and St. Bonaventure.


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