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More 2006 Words
Words for "Sharp"
Digression on "Horns"
On "Heaps"/Sorites
Collective Nouns I
Collective Nouns II
Collective Nouns III
Collective Nouns IV
Collective Nouns V
Onychophoran I
Onychophoran II
Chameleon, et al.
Hard-Favored, et al.
Ariadne in TG
Orpheus in TG
The prefix "Expi"
"Expi" II
High Five/Hillbilly
"Making Out"
Other "Makes"
"O" Words
Nostalgia I
Nostalgia II
Nostalgia III
Minding Your "P's"
Minding Your "P's" II
Words for "Red" I
Words for "Red" II
A Historical Irony
Stemwinder I
Stemwinder II
Stemwinder III
Glister, Spraddle etc.
Matter of the "Heart"
Dabchick, et al.
Dalmatic et al.
Decline of Language?
Language Decline? II
History of Insults I
History of Insults II
History of Insults III
History of Insults IV
History of Insults V
History of Insults VI
History of Insults VII
Words Beg. with "Ga"
"Ga" Words II
Insults ag. Women I
Insults ag. Women II
Argot of Addicts I
Argot of Addicts II
1997 "Bee" Words
1997 Words II
1997 Bee Words III
1997 Bee Words IV
1997 Bee Words V
Bill Long 11/29/06
English Only, At This Point
This and the next essay are only impressionistic historical pieces. Much more could be done on this vital, and often overlooked, area of cultural expression. My thesis is that we can tell quite a bit about the culture by understanding when and how its insult words have developed, morphed, and faded in and out of the language. I argue here that in the history of English there are three formative periods of insult-creation: (1) the late 16th-late 17th century; (2) from 1900-1935; and (3) 1955-1980. I focus here primarily on single-word insults. Much more could be done on phrases or insult similes, as well as the development of insults in other languages.
The Early Period
This period extends for me from the invention of blockhead in 1549 to the coining of numbskull in 1697. Interestingly enough, however, the first usages of blockhead were descriptive rather than directed at a person. Miles Coverdale, commenting on Erasmus' paraphrase of I Corinthians 11:14, said: "A blockheade that hathe loste the judgemente of nature." Shakespeare, who seemingly used every word known to man, and invented a good deal more, could say in Coriolanus, "Your wit..'tis strongly wadg'd up in a blocke-head." The term derives from the wooden block that was usually used for hats or wigs. A blockhead therefore had no more intelligence than such a wood block. I love the fact that the earliest attestations are in theological works, for that is the place to find deepest animosity in the 16th and 17th centuries. From 1593: "Bee he the veriest blockhead under heaven."
What is interesting to me here is that the English language, at this point, has come up with terms of derogation but doesn't use them yet as terms of address. Except for the popular "Fool!", which some might argue isn't a term of derogation at all, language seems to be inching along, reaching for a concept (that of insult) that is so prevalent to us that we can barely imagine it not existing.
Well, here are a few other words from the early period. Ninny, perhaps first used as a shortened form of "innocent," and therefore not a derogatory term, appears first in 1593. From 1609 we have: "Not long since I discovered a nest of Ninnies in this great wombe the Worlde." Dunderhead is first attested in 1625 and means "a ponderously stupid person; a blockhead." No one knows the origin of this term, but some have connected it with the German "donner," to suggest thunder, a blow or loud noise. From 1625 we have "Oh, thou dunderhead! Wouldst thou be ever in thy wife's Syntaxis?" Syntaxis here, though literally meaning "grammar," also has a more racy connotation. Simpleton is attested first in 1650 to mean a person deficient in sense or intelligence. "If a solemn Synod may erre, what may a single Simpleton doe?"
What is significant for me from the "early period" so far is that the words/insults introduced primarily suggest deficiency of knowledge. They are not particularly derogations of character. Perhaps as Britain was expanding in the early 17th century, after its defeat of the Spanish Armada, what was most impressive to the nation was how ignorant of the world they really were. Displacing their ignorance on truly slow people, the culture invented these words: blockhead, dunderhead, ninny, simpleton.
The Early Period--A Few More
Let's conclude this incomplete list by introducing nincompoop and numbskull. The OED suggests that the former, first attested in 1673, may be derived from the French nicodeme, meaning simple or naive person (derived ultimately from Nicodemus, the one who "came by night" to see Jesus because he was ignorant of who Christ was), but I think that is a stretch. Samuel Johnson, the great biographer and lexicographer of the 18th century, suggested its origin from the Latin non compos (not understanding). In any case, a nincompoop is a simpleton or fool. From 1673: "Yes, you Nicompoop, you are a pretty Fellow to please a Woman indeed." Sterne's Life of Tristram Shandy (1760) puts it together with other words neatly: "In doing it, or after he had done, had he looked like a fool--like a ninnny--like a nicompoop." The spelling of it as in our own day (nincompoop) is also attested in the 17th century.
I was delighted to see that nincompoop is the fertile mother of children, such as nincom (1800, simply a shortened form) and nincompoopery (1900). The latter is used to describe foolishness or stupidity. Sinclair Lewis says, for example, in Arrowsmith: "Were they, in their present condition of nincompoopery, worth any sort of attention?" I was delighted to see that nincompoopiana developed around 1880, though it was used as a name for a late 19th century aesthetic movement. The London Times explained this in 1970: "'Nincompoopiana' began in the 1880s and was triggered off by the aesthetic movement which rebelled against the pretty and the respectable, and by the 'new woman.'" Very very nice, isn't it? Finally, there is nincompoopish (1852) which means "characteristic of or resembling a nincompoop." And, why was it invented in 1852, in America no less? Possibly because this was the height of the "Know-Nothing" movement in American politics. From 1852: "It is perhaps the deepest misfortune which should befall mankind now, that for the ensuing Presidential term the rule of the United States should be in the hands of the nincompoopish or the imbecile."
I am emboldened by all of this to try to make up my own words. How about a nincompooper? You could imagine several things that such a person would do. Or nincompoopdom, as the place where they tend to congregate? The possibilities, though not endless, are multifarious.
Well, this has gone on too long, but let's quickly conclude with numbskull. A 1699 dictionary has the following: "Num-skul, a Foolish Person." The first actual usage of the term was in 1697, and was spelled numpscull. "You take me for a numpscull." The OED hypothesizes that the numpscull spelling might well indicate an origin from numps, another "insult" term coined at the end of the 16th century. A numps is a silly or stupid person, as this 1599 quotation shows: "Lustie Humfrey, according as the townsmen doo christen him, little Numps, as the Nobilitie and Courtiers do name him." Oops, I see this essay could go on forever, since we have, in another quotation on numps, the word "noddie," which also comes from the 16th century and means "fool" or "simpleton."
Let's close this by summarizing where we are. We are not trying to be complete, but I have argued a thesis about the origin of insult words. The ones I suggest here are, in order, blockhead, ninny, dunderhead, simpleton, nincompoop and numbskull. Others, such as noddie or numps, could also be discussed. Let's go on, now, to the "modern" period of insult-development.


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- July 10, 2013
- 8:04 a.m.
- Suggest removal
- Reply to this post
fran-bob#251823 writes:
Do you have the picture of Guyla Vann leading the N. Mason Relay for Life? I would like to purchase that photo. I think it was July 3rd or 4th.
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subset: commoncrawl


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Accounting Concentration
Goodman School of Business
Accounting Concentration
- Cost Accounting
- Financial Accounting
- Financial Auditing
- Forensic Accounting
- Tax Accounting
- Junior Accountant
- Senior Accountant
- Audit Officer
- Accounts Payable Clerk
- Account Executive
- Payroll Accountant
- Commodity Tax Analyst
- Accountant‐Assurance & Business Advisory
- TECHNICAL COMPETENCIES in advanced financial reporting, strategy and governance, and management accounting, as well as in audit and assurance, finance and taxation.
- ENABLING COMPETENCIES including professionalism, ethical behavior, written and oral communication, leadership, problem-solving and decision-making.
- ACTG 4P11‐Accounting Theory
- ACTG 4P12‐Integration & Problem Solving
- ACTG 4P34‐Accounting for External Reporting
- ACTG 4P40‐Tax Strategies for Planning & Decision Making
- ACTG 4P41‐Taxation
You can also put your accounting knowledge to practice by participating in accounting case competitions hosted by various universities such as the University of Waterloo, Ryerson University, and Brock University.
- Brock University Accounting Students' Association (ASA)
- Brock University Accounting Conference (BUAC)
- Business Students' Association (BSA)
- Institute of Chartered Accountants of Ontario (ICAO)
- Certified General Accountants (CGA) of Ontario
- BDO Canada
- Deloitte & Touche LLP
- Ernst & Young LLP
- Grant Thornton LLP
- PricewaterhouseCoopers LLP
- How To Get A Job In Accounting – meet alumni and industry professionals
- CA Day – meet recruiters from large and mid‐sized accounting firms
- Problem Solving
- Demonstrate Initiative
- Adaptability to Change
- Communication Skills (verbal and written)
- Detail-Oriented
- Interpersonl and Relationship Management Skills
- Analytical Skills
- Work Independently and in a Team
- Leadership
- Techological Proficiency
- Time Management
- Ability to Self-Manage
I have had many diverse experiences as a Brock business student, which I contribute to the development of both my personal and professional business skills. By taking advantage of the co-op program at Brock, I have had the opportunity to work at two career developing positions in accounting at both Walker Industries Holdings Limited and Research In Motion. The hands on experience mixed with the accounting foundation built in the classroom, and the support of my coop advisors have allowed me to experience aspects of the business world that transcend the classroom and textbook. This combination of knowledge will enhance my marketability when looking to begin my career, as well as jump-start my studies when trying to complete my CMA designation. By taking advantage of the exchange program that Brock offers, I am looking forward to understanding international accounting practices coupled with experiencing the European culture firsthand.
-Neil Bourque, BBA Accounting student


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Will HP, Dell, Sony answer 11-inch MacBook Air?
Neither Dell nor Hewlett-Packard nor Sony have laptops that compete directly with the 2.3-pound, 11.6-inch MacBook Air. Is this a new market segment that those three laptop leaders and others will have to address?
Apple has a knack for creating new markets, the iPad being the most recent example. Though not as groundbreaking or broadly market-defining as the iPad, the smaller Air is clearly unique: wrapped in aluminum, while considerably lighter than a typical 3-pound 11.6-inch laptop. And it packs higher-end silicon--and better performance--than Netbooks. (I spent some time in three different Apple stores in the Los Angeles area right after the new Airs were announced, and from what I saw, the 11.6-inch MBA elicited the most oohs and aahs--hands down.)
I would submit that the Air has wedged itself (pun intended) into an elite sub-2.5-pound laptop segment where little direct competition currently exists. There are hordes of 10-inch class Netbooks out there. But, again, a $350 Windows 7-based Netbook is a very different class of laptop. Then there are products like Dell's 11.6-inch Inspiron M101z. But that is a low-end plastic Netbook-class product.
Lenovo--though not listed up top--warrants an honorable mention with its IdeaPad U160 11.6-inch laptop, which has the screen measurements to match the 11.6-inch Air but is about a pound heavier and for all intents and purposes is a fairly conventional Intel Core i series-based laptop that's been squeezed into a tight form factor. And Acer has the 11.6-inch TimeLineX series, but this is 3 pounds and really not in the same class as the Air.
As pointed out in a previous post, Sony has its Vaio X, Y, and Z series, but the former is a Netbook, and the latter two are 13-inch designs, which are not nearly as sleek and small (at 4 pounds and 3 pounds, respectively) as the 11.6-inch Air, albeit the Vaio is competitively priced and offers faster Core i series processors and higher-end Nvidia GeForce GT 330M graphics. But, again, size is the key metric for comparison. … Read more


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BeerAdvocate on your phone?! True story. Try the beta now.
Tickets for American Craft Beer Fest are on sale now! (May 30 & 31 in Boston, MA)
Kuhnhenn Raspberry Eisbock - Kuhnhenn Brewing Company
Displayed for educational use only; do not reuse. |
Ratings: 788 | Reviews: 410 | Show All Ratings:
Reviews by Hoptologist:
More User Reviews:
4.21/5 rDev -4.3%
look: 3.5 | smell: 4.25 | taste: 4.25 | feel: 4.25 | overall: 4.25
Big thanks to Adam for getting this to me in trade. 2012 bottle with red wax poured in a Firestone Walker Teku on February 13, 2014. Pours bright and dark red with no head at all even with a vigorous pour. Huge sweet raspberry and booze aroma, some caramel or toffee, lots of sweet syrupy sugar smell. So much sweet berry. Flavor is sweet straight raspberry jam/preserves, and then some toffee like malts tingling the tongue with plenty of booze in the background. This is very sweet with a thick nearly syrupy mouthfeel but balanced with some light carbonation as to make it more drinkable. Huge flavors in this brew for sure. Made for the raspberry lover. Very nice and a bit hot. An awesome treat as an after dinner drink, just make sure to pour yourself a small glass around 4 oz. Tough to drink much more than that.
Serving type: bottle
02-14-2014 01:05:33 | More by BMMillsy
Kuhnhenn Raspberry Eisbock from Kuhnhenn Brewing Company
out of 100
based on 788 ratings.


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Apr 22
So you have planned. You have a strategy. You are ready.
Are you really?
Apr 22
So you have planned. You have a strategy. You are ready.
Are you really?
Mar 25
The most distinct benefit of cloud computing is its inherent cost effectiveness. However, the cloud offers another advantage that is not so pronounced: disaster recovery.
Traditional hosting plans offer several options for a variety of disaster recovery needs, but these options still pale in comparison to those offered through cloud hosting. Since the physical servers are located in a very secure data center, information is kept safe—even during natural disasters such as hurricanes and earthquakes.
Feb 25
The business world today is all about staying current and competitive in your industry. As your small business looks to the future, consider these tech upgrades to help your business remain up to date and competitive in today's market. The following suggestions are relatively easy and affordable for most small businesses to implement:
Ensure Your Internet Speed is Up To Par
How does watching football on Sunday translate into to-do's for Monday? More than 100 million people watched the Super Bowl on Feb 3rd, they were expecting a great game and some good entertainment. What they got was almost a disaster for CBS. In the recovery planning business, we are always trying to minimize the likelihood of an incident becoming a disaster. CBS did an excellent job of this on Sunday.
When the power went out in half of the Superdome and the game was stopped unexpectedly, CBS did a good job of keeping people entertained for the 34-minute delay. While they likely didn't plan for the lights going out in half of the building, they did have a contingency plan for the power going out and as a result were able to keep most fans watching the commercials and the announcers. The numbers aren't available yet, but they might have sold more commercials because of the extra prime-time viewership the "abnormality" created.


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Film Piracy, Organized Crime, and Terrorism
www.rand.org Gregory F. Treverton discusses how organized crime is increasingly involved in the piracy of feature films, with syndicates active along the entire supply chain from manufacture to street sales of pirated movies. Video Rating: 2 / 5
Japanese Coast Guard tried to kill Paul Watson from Sea Shepherd. 日本の沿岸警備隊は海の羊飼いからのポールワトソンを殺すことを試みた。 More info on : www.sea shepherd.org or in German on blog.migaloo.de Video Rating: 2 / 5
25 Responses to "Film Piracy, Organized Crime, and Terrorism"
to paul watson:
You Liar! 0:18 bad acting mahn. . -
Thanks for the hard work Paul Watson, and crew.
嘘だ! -
@mongration get a life idiot
They are just flash grenades. A rifle round that would finish a whale kill would have blown him away completely.
ha ha ha ha
monkeyshow very bad!paul watson is liar
what a looser, paul needs to quit lying and someone really shoot him
evil japs
so flash bang equals gun shot? idiots.
how is that attempted murder if its so fake??? must be out your crack smoken mind
@Yemoeaung86 and trust fund babies
Oh no! Not a useless grandstanding pile of crap that is doing more to damage the cause he says he represents! How ever will they survive in their oceans of blood in the sea!!!
Sea Shepherd members are just a couple of job less people.
@Dingwell88 You are gravely mistaken about the Navy running from high sea states. For our smallboys (frigates/destroyers) they will avoid high sea states if it doesnt interfere with any missions. The main reasons is so they can maintain a Ready Deck, for incoming helos as they are our devert landings in blue water ops. Also matters if they are part of battle group or off on their own.
The supposed being shot is completely fake. The size of the shrapnel he pulled out of that vest would of put him on the deck if he had been actually hit with that caliber shot. Anyone who has actually seen combat and knows what it feels like to get shot even with the vest on, you dont go..hmm i think i may have been shot. You know instantly and it is quite painful.
@baine1985 Yeah for sure, Ive thought this was fake all along.
@selgemm Here's a nice little tidbit for you dude. Japan does not allow its private citizens to own firearms. That includes companies that operate outside of Japanese Maritime borders. So unless they had a JNSDF rifleman on that fishing vessel, with an illegally procured firearm, this is horribly faked just to get his fat ugly face in the news.
@Dingwell88 Piracy, any robbery or other violent action, for private ends and without authorization by public authority, committed on the seas or in the air outside the normal jurisdiction of any state. (it goes on).
Encyclopedia Britannica -
@Dingwell88 Well, whatever you are, more power to you. I doubt the Sea Shepherd was in a Force 10 storm when they engaged the Japanese during this video. (see Beaufort scale for those without a nautical background). From the size of the seas you describe, I would say…New Zealand or Australia, maybe Tasmania. Then again, you could be a Scot, or (God forbid) Irish….lol, just kidding..(I'm of Irish descent). Only one of such descent would be crazy enough to go out in such seas.
@plbuster Wrong again, I am not a Limey. Haha so you went out in sea state 3 or 4 and had it rough eh? Haha We are in 9 – 12 METERS last fall when on a multi-national ex. I know it isn't the same as being on a sailboat but try and picture that. That is a 4 story building.
As much as I hate these SS morons they are not considered pirates. Too bad it would make things much easier.
Oh and of course the US wouldn't be signed on to any convention. They never do. Might surprise you to know that.
@Dingwell88 Aha! a freakin Limey! go figure. Who else would be so naive, so socialist, so….well…
Yeah, I've been on more than one "sail". Gotta 22′ Catalina in the back yard on a trailer. Sailed it to West End, Grand Bahama Island once, in 6-8 foot seas. Wretched my gut up for a whole day.
Oh, and pirates are not protected by the Geneva Convention, nor any treaty signed by the Japanese, the US, or the United Kingdom. -
@plbuster Obama huh? Haha typical Yank. You assume that everyone else is too. I love most of the bullshit you toss around this site. Shit like the Japanese Defense Force can get involved with few repercussions. Yeah you might wanna check out some convention….might have been signed in Geneva….something about attacking non-combatants. Too bad it isn't so simple
Oh and if you think pitch and roll are that predictable you should go for a sail. Only problem is that your Navy runs from sea state. -
HAHAHAHAHA nice try watson.. lol what a joke..


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Long Island Memories
Carnival Time At High School The Student Council of Farm-ingdale Senior High School will hold their first Farmingdale Carnival this Saturday at Farming-dale High School. A member of extra - curricular clubs and organizations will sponsor booths and concessions in order to earn money for their clubs. There will be food concessions, games and prizes. For the kiddies, there will be a special cartoon show at 2: 30 and again at 4: 30 p. m. There will also be special booths sponsored by the Photography club taking both gag and portrait pictures. The Carnival will be open from 2: 30 - 4: 40 p. m. for kindergartener to sixth grades and at night from 7 to 11 for grades 7 and up. Admission to the fair is 25£. Pre Easter Services To Highlight Noted Speaker Pre- Easter services will be held this Sunday, April 7 and will continue each evening through Friday at the Farmingdale Baptist Church. Dr. Don Dyer, Pastor of the Plymouth Park Baptist Park Irving, Texas, will be the guest speaker for the week's series. The speaker was selected pastor of the year in Texas. Sunday night services will begin at 7 p. m. Monday through Friday services will be held at 8 p. m. Officer Induction Slated By E. Farmingdale Industrial Group Induction of new officers will highlight the April meeting of the East Farmingdale Industrial Association at a Dinner- Dance to be held on Saturday, April 20th at 8: 00 p. m. at Ruby's Club Room, 104- a Allen Blvd., Farmingdale. Captain D. C. Huebner of the United States Navy will be our guest of honor. Those interested in attending, may call 694- 1330. Israeli Official To Address Sisterhood Bermon Yeuhuda, a member of the Israeli Consulate will speak on the topic, " Israel After the War" at the Sisterhood of the Farmingdale Jewish Center's next regular meeting on Tuesday, April 9 at 8: 30 p. m. at the Farmingdale Jewish Center, Prospect Street and Cobb Place, Farmingdale. TOB Expands Counsellor Training Course The Oyster Bay Town Department of Recreation this week expanding its counsellor- in-training course to also include volunteers working in the handicapped children's program. Town Board Majority Leader, Ralph J. Marino, said the program initially only for high school juniors and seniors, prepares students for jobs in camping and as counsellors. The special course being added is for volunteers working in the town's group activities program for handicapped children. Also included in the course are: adapted games, first aid, health, safety, special programs, arts and crafts and a discussion and film pertaining to working with and understanding the handicapped. Herbert Malamed, Plainedge physical education instructor, is conducting the course every Tuesday, 7: 30 to 9 p. m. at the Oak Drive School in Plainview. Further information may be obtained from the Recreation Department at 921- 5975. AUTO INSURANCE Youngsters, Oldsters Monthly payments, discounts dividends, auto loans Telephone Service MURRAY TUCK, INC. 388 Fulton St., Farmingdale 249- 1473 Columbiettes Plan Luau The first annual Luau is being planned by the Farmingdale Columbiettes for Saturday, April 2 at 8 p. m. at the Knights of Columbus Council Home, Farmingdale. Mrs. Thomas Lalicki is chairman of the event. Serving on the committee will be Mrs. George Miller and Mrs. John Leahy, President of the organization. Datebook FRIDAY, APRIL 5 12 Noon: Vice President Hubert Humphrey at Long Island Association luncheon, Huntington Town House. SATURDAY, APRIL 6 2: 30 to 4: 30 p. m. 7p. m. to 11 p. m. Carnival with food concessions, games, sponsored by the Student Council of the Farmingdale Senior High School, High School gym, Lincoln Street and Intervale Avenue. SUNDAY, APRIL 7 2 p. m. Farmingdale Kiwanis Easter Egg Roll, Weldon, E. Howitt field. TUESDAY, APRIL 9 8: 30 p. m. " Israel After the War", member of Israeli Consulate to speak at Sisterhood meeting, Farmingdale Jewish Center. Obituaries Thomas J. Flynn of 104 E. Carmans Rd., E. Farmingdale passed away on Tuesday at Brunswick Hospital, Amilyville. He is survived by a sister, Gertrude Itjen of the same address. A Requiem Mass will be said at St. Kilian's R. C. Church mis Friday, at 9: 30 a. m. Interment will follow at St. Charles' Cemetery, Farmingdale. Funeral arrangements are under the direction of the Arthur F. White Funeral Home. * * * John L. Gotab, age 12, of Melville passed away at Huntington Hospital. The son of Violet M. Gotab and the late, Louis J. Gotab, he is survived by his grandparents, Adam and Anna Gotab of Farmingdale and a sister, Paul-ette. A Requiem Mass was recited at St. Kilian's R. C. Church on Tuesday, followed by interment in Long Island National Cemetery. Funeral arrangements were under the direction of the Arthur F. White Funeral Home. CAP Gets Top Rating For the second year in succession, Nassau Composite Squadron Five, Farmingdale - Bethpage Civil Air Patrol has been a-warded top rating by the New York Wing in information activities standings for 1967. The ratings recently released by the National Headquarters placed the local squadron in the top spot above 166 other chartered units in the state. Information activities cover a variety of public relations items all of which tell the Civil Air Patrol story such as news releases, photographs printed, radio spot announcements, exhibits, speaking engagements, film showings, special reports and activities. The squadron Information Officer, JaySchleichkornof Farmingdale, a Major in the Air Force Reserve assigned to C. A. P., will be the recipient of a special certificate to be presented by the Wing Commander at the Annual Wing Conference scheduled for Saturday, April 6th. in Mon-ticello, New York Newly elected Board Members ot the South Oyster Bay Unit of the American Cancer Society, discuss one of the Units special promotional programs, " Buck Cancer with a Buck" following their recent installation. Pitcured 1. to r. are: Mrs. George Archer of Farmingdale; Dr. Marvin Meister of Masspaequa; Preston J. Corsa of Farmingdale and Mrs. Goldrich Foucek of Farmingdale. The Unit completed plans to launch the Division's 1968 Educational Fund Raising Crusade which started this week. More than 3,000 Crusaders will conduct the campaign in the Massapequas, Farmingdale, Bethpage, Hicksville, Old Bethpage and Plainview. PRICEFIGHTER SPECIAL KNOCKOUT SALE of ' 68 PONTIAC EXECUTIVE CARS Sorry, We Can't Print Prices Come In... You'll BUY, We Promise! at the sign of the friendly Buddha " Where the Customer is King" 3333 SUNRISE H'WAY P O N T I A C WANTAGH, LI. • 781- 6666 Travel Time from: Formingdale- 15 min. south on Wantagh- Oyster Bay Expressway A LARGE SELECTION OF Foreign Language Cards Easter paper products Complete line of Gift Items • Pens, Pencils • Tobacco products • Stationery / fiwtT\ 1 9ive our !' • Schraffts • Whitman's NORMANS STATIONARY 326 MAIN ST. MY 4" 0488 FARMINGDALE J ,. fgrrnijngdgk OBSERVER, TKM/ sqigy, April 4, W 8 Pgpe?
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WebMD Interviews President Obama
Submit your questions about the Affordable Care Act for President Obama, then return on March 14 to watch the interview.
Do you have Borderline Personality Disorder? This new Exchange has been developed so we can encourage each other, share tips to get through those down days, and/or just vent.
Spotlight: Member Stories
Hi, my name is Brittany. I was raised in an emotionally, verbally, and physically abusive household. I just moved out of that household a year ago (I&...More
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Some Traits Common to People with BPD
People with BPD may have other attributes that are not part of the DSM definition but that researchers believe are common to the disorder. ... More
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Election Coverage
9:11 pm
Wed October 31, 2012
Candidates and surrogates making the most of Ohio appearances
Two new polls show the presidential race is tight in Ohio, but both polls give president Obama a slight edge. the CBS/Quinnipiac/New York Times poll shows Obama with a 5 point lead, while the Ohio Poll by the Univversity of Cincinnati shows him 2 points ahead of challenger Mitt Romney. Jim Messina, campaign manager for Obama says the the Romney campaign is propped up with inaccurate information.
Messina: We have the math, and they have the myth. Whether we're talking about getting out the vote or bringing down the deficit, our numbers add up. The Romney campaign is trying to sell illusion and delusion.
Messina says the president has a better ground game and adds polls on early voting show him with double digit advantages. The Romney campaign disagrees with Messina. Russ Schriefer, a pollster for Romney, says Obama's approval rating is under 50 percent, and that's not where an incumbent wants to be at this point. And Schrieffer says Romney has an excellent closing message. He believes Romney is leading with independents and is poised to win the Buckeye State. Ann Romney rallied with her husband's supporters in Ohio today, including a stop at a company in Butler County. She spoke to an audience of several hundred people who gathered at VinylMax Windows in Hamilton...
Romney:We have a big choice to make, and I think Ohio's going to be a big piece of that. You aall know how important Ohio is, and this part of Ohio is very important to us.... We have to get out there and get our message out that it is a critical time for the nation's... for the course we're going to take for our country.
Ohio Lieutenant Governor Mary Taylor, along with Cindy McCain, the wife of 2008 GOP nominee John McCain, and Jane Portman, the wife of U.S. Senator Rob Portman were also at the rally. all expressed their support and confidence that Mitt Romney's policies would get the country moving in the right direction.


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Sinclair Community College Men's Basketball program, nationally ranked during the last three years with one conference championship, has implemented an exciting new package to allow you to contribute to their continuing success.
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Additionally, all Sixth Man Club members will have access to any practice and will receive weekly email updates. Your contribution will assist the Men's Basketball Program with numerous community service projects, the Player Enhancement Program (PEP), and allow them to use away games as an opportunity to visit a variety of educational sites, such as the White House, not to mention personal growth and team building exercises.
Make checks payable to Sinclair Men's Basketball
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Mail this slip to:Sinclair CC – Sixth Man Club
c/o Sinclair Foundation
Building 12, Room 12201


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Is it worth a minimum of say, three Andy Jacksons to see Bob Dylan on Saturday at Sleep Train Arena?
That would be the 71-year-old grandfather of nine, contemporary of the Beatles, Medal of Freedom recipient, multiple Grammy winner, somewhere north of cultural icon who transformed rock 'n' roll and single-handedly kicked down the barricade that would have shut out Neil Young, Joni Mitchell, Warren Zevon, Jackson Browne, Kate Wolf, Steve Goodman, John Gorka and several subsequent generations of songwriters.
Like so much in life, the value of an investment depends on the return expected.
An easy three-Andy investment would be the redoubtable Mark Knopfler, who opens for Dylan and whose guitar virtuosity has enlivened several previous Dylan albums.
If Dylan wants to brood in the dressing room and Knopfler can offer up more of his compelling two-CD, 20-song album "Privateering," so much the better. Not that there's been any doubt as to Knopfler's caliber as musician and tunesmith since the first album by Dire Straits 30-some years ago.
Bottom line: Whoever Dylan is Saturday night, it's a bonus. Experiencing a performance by Dylan isn't vital by any means. But it's certainly valuable in appreciating the man's extraordinary social and musical impact.
True, his shows would benefit from him tearing a page out of Demosthenes' playbook and wedging a large jawbreaker between cheek and gum to improve diction.
Dylan is very forthright in alerting potential concert- goers that their evening won't be spent with the earnest folk singer of a half-century ago, the androgynous provocateur of "Blonde on Blonde" and "Highway 61 Revisited," the bucolic bard of "Nashville Skyline" and "John Wesley Harding," the wistful divorcé of "Blood on the Tracks" or the praise-giving believer in "Slow Train Coming" and "Saved."
Ditto for the personas in between.
"When you ask some of your questions, you're asking them to a person who's long since dead," Dylan told Mikal Gilmore in a wide-ranging, late-September Rolling Stone interview.
"I would love to go back and find him, put out my hand. And tell him he's got a friend. But I can't. He's gone. He doesn't exist."
Dylan denies it in the same interview but, over the past decade or so, he's become something of the craggy bluesman who appears intent on going down swinging in both the Sonny Liston and Sonny Boy Williamson senses.
It's impossible not to think Muddy Waters, Howlin' Wolf or John Lee Hooker when hearing a number of the hooks of Dylan's most recent songs. He often credits his inspirations, such as Delta bluesman Charley Patton on "High Water (For Charley Patton)."
His band, as it's been for several decades, is so ridiculously proficient it's not uncommon to leave thinking that Dylan, hunched behind his keyboard (arthritis hamstrings his guitar-picking), isn't exactly bringing it all back home.
Judging from Dylan's 2012 set lists through early this month, between a third to nearly half of his usual 15 to 16 songs are tunes written beginning with his 1997 album "Time Out of Mind."
He's opened several shows with the greatest Tao rocker of all time the 40-odd-year-old "Watchin' the River Flow," and he invariably includes "Tangled Up in Blue," with its evocative back-and-forth third person/ first person narrative.
The final five songs of each show appear chiseled in stone: "Thunder on the Mountain" from 2006's "Modern Times," with its tip of the hat to Alicia Keys; "Ballad of a Thin Man," whose "something is happening and you don't know what it is" coda is still as chilling as when it was first placed on vinyl 47 years ago; and, all too predictably, "Like a Rolling Stone," "All Along the Watchtower" and "Blowin' in the Wind."
Fine, but a sprightly reggae version of "Knockin' on Heaven's Door," plaintive "I Shall Be Released" or epic "Brownsville Girl" also would fit neatly into the final five or be welcome substitutes for some of the "new" tunes.
Dylan says he feels a stronger affinity for the material of the past 15 years. And, hey, he's the one going out month after month, year after year, all over the world on what's often called his "Never-Ending Tour." So how best he floats his own boat is probably the most important issue. Certainly to him, anyway.
The problem is for those with multiple decades of familiarity with the prodigious output of the most famous native son of Duluth, Minn., the "new" tunes don't provide anywhere near the same number of thrills from unexpected rhymes or the jaw-dropping kaleidoscopic imagery of just to pick one song "Desolation Row," which Dylan has been performing periodically this year.
Then again, Dylan loves to shock and surprise. He's done it for decades.
Odds are, Saturday won't be an exception.
What: Concert, with Mark Knopfler opening
When: 7:30 p.m. Saturday
Where: Sleep Train Arena, One Sports Parkway, Sacramento
Cost: $62.50-$82.50
Information: www.ticketmaster.com, (800) 743-5000
© Copyright The Sacramento Bee. All rights reserved.
Read more articles by Greg Lucas


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Can These Firefighters Save a Kitten Trapped in a Car Engine?
This engine purrs like a kitten.
This engine purrs like a kitten.
Taylor Swift's latest breakup? Her publicist of seven years.
Girls playing with Barbie dolls is such a normal part of childhood. But for those concerned about the "perfect image" Barbie presents to girls, meet Lammily, the average and beautiful anti-Barbie doll.
Spring is near right? We made the switch to Daylight Savings Time and Bonomo's in Kirkland opened are just a couple of the things that indicates it's true. Apparently Mother Nature isn't paying attention. The National Weather Service has a Winter Storm Watch click for the details.
What an incredible lesson we all can learn from this 3 year old. Emily James thinks that when we have lots of something, we shouldn't hold onto it, we give it away to someone else who needs it more. With help from her hairstylist uncle, she gets her hair cut and donates it for cancer wigs
Take a glimpse at how the Toons and the humans from 'Who Framed Roger Rabbit?' look today.
Lite 98.7 is proud to participate this year's Utica St. Patrick's Day Parade. It's going to run from 10 a.m. until noon on Saturday, March 15th, 2014.
It's time to dust off the crystal ball. This year, 63 intense college basketball games will fill up the college basketball championship tournament bracket – it's your job to figure out who wins each one.
Now that CG-animated films are more common, stop-motion has become more magical than it ever has before. Laika is a studio that built its name on doing this kind of work better than anyone else, creating modern gems like 'Coraline' and 'ParaNorman.' Can their latest effort, 'The Boxtrolls,' live up to their legacy? If the new teaser trailer is any indication, all signs point to yes.
Soon the snow will melt across Central New York and parents will be taking their kids out to parks and playgrounds around the area and in West Utica, sadly, there is new graffiti at the Addison Miller Park playground.
No you don't need to alert the Utica Zoo of any animals that escaped, but there was a bear sighting in downtown Utica on Sunday March 9 as the Berenstain Bears LIVE show made a stop at the Stanley Theater.
We have a good feeling about 'Oculus.' As the latest release from Blumhouse Productions (the folks behind 'Paranormal Activity' and 'Sinister'), the horror film follows a young woman who attempts to clear her brother's name after he is accused of a crime that was actually committed by a creepy supernatural entity living in a mirror. The full 'Oculus' trailer has arrived, and it looks like it'll have its fair share of chills and scares.


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10 Ways to Craft with Old Sweaters + 5 New IdeasInstead of tossing old and unused sweaters, turn them into something new and completely loveable. Crafting with old sweaters saves money on craft materials and helps to reduce your household waste. 19 Loom Knitting PatternsLoom knitting is a great way to break into knitting if you haven't quite gotten the hang of knitting with needles. Learn all about knitting looms and looming patterns using our free loom knitting patterns! Cathedral Pin CushionThis Cathedral Pin Cushion is perfect for storing all your pins. Make one for yourself and all your friends! Cute and unique pin cushions like this make great gifts and are easy and fun ways to use up any fabric scraps you have lying around. Double Stitch Twins: Erika and Monika SimmonsDouble Stitch is the brainchild of the multi-talented twin designers Erika and Monika Simmons. This collection of fun and flirty hand crochet apparel transcends fads and seasons. Easy Paolo PurseAn easy crochet pattern like this one is fun to carry around. The different colors compliment each other nicely and the design is fun and fashionable. Double crochet and single crochet is used. Loop Fringe Crochet ChokerThe loop fringe crochet choker is a free crochet pattern that will teach you how to crochet a necklace. The pattern, from Double Stitch Twins, is the perfect accessory to add to any outfit! Newsboy Hat Crochet PatternWant to make a stylish newsboy cap for yourself or a friend? This simple Newsboy Hat Crochet Pattern by the Double Stitch Twins for Red Heart Yarn makes it so easy, you'll want to crochet newsboy caps in all colors of the rainbow! Remix CuffThis remix cuff tutorial by the Double Stitch Twins shows you how to remix some old denim into a trendy cuff using some easy crochet techniques. Use this free crochet pattern to remix your wardrobe. Shamrock Wall HangingMake this easy Saint Patrick's Day craft from Amanda Formaro with your kids this year. This project uses up all of those old paper bags you have lying around. Simple Fabric PostcardMake a big impression with a little piece of mail. Create a Simple Fabric Postcard using scraps and cardstock. This is a fun alternative to a generic, store-bough card. Next time you travel, send a homemade postcard to someone you love. |
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By Xingshu Sun1, Mark Lundstrom1, raseong kim1
1. Purdue University
Calculate the Fermi-Dirac integral given the fermi energy and the order of integral
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Pinkerton will help you examine all risk areas of your business and operations – both inside and outside of the company – that can impact your organization's value. To help protect this value, Pinkerton mitigates the four core risk areas that impact businesses: Hazard & Event Risk; Operational & Physical Risk; Market & Economic Risk; and Technology & Informational Risk. See how our uniquely holistic approach to risk management at Pinkerton is designed to keep your entire company safe and secure. Read more »
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Acton University is a unique, four-day exploration of the intellectual foundations of a free society. Guided by a distinguished, international faculty, Acton University is an opportunity to deepen your knowledge and integrate rigorous philosophy, Christian theology and sound economics.
At Acton University, you will:
Build your own curriculum. Choose from more than seventy courses ranging from the theological and philosophical, to the policy-oriented and practical.
Learn from world-class faculty. Meet leading authorities on economics, theology, public policy, globalization, the environment, and other disciplines.
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Equip yourself to engage in the debate. Better articulate your understanding of the Judeo-Christian view of liberty and morality and its application in a free and virtuous society.
Purchase a subscription to the Journal of Markets & Morality to get access to the most recent issues.
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October 31, 2006
"Everything's big in Texas," and this year's Texas Technology Showcase on December 6-7 in Galveston promises to be no exception! Hosted by the Texas Industries of the Future, Texas State Energy Conservation Office, Texas Commission on Environmental Quality, and the U.S. Department of Energy, the 2006 Showcase focuses on energy saving technologies and management practices for the Chemicals and Petroleum-refining industries. Attend the Showcase and learn about the tools in the Engineer's Energy Toolbox: Practices, Technologies, and Management, from best practices in programs and new technologies that are proving themselves today, to long-term energy management strategies.
The two-day conference features four concurrent technical sessions, three plenary addresses, an awards ceremony recognizing top companies' achievement in energy efficiency, an exhibit hall, and opportunities to network with colleagues.
Attend the four technical sessions to learn about:
No Showcase would be complete without the best and brightest new technologies. Here are just some of the revolutionary new technologies and processes featured:
And, be sure to visit the Exhibit Hall, which will feature more than 30 companies exhibiting technologies and services for energy efficient and environmental applications.
Reserve your spot today for this premier event! Early bird registration ends November 13! More information and to register.


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Centre for Metropolitan History
The Aldermen of the City of London: Temp. Henry III - 1912
Alfred P. Beaven
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Citation Show another format: BHO MLA Turabian Chicago MARC21 Wikipedia
'Discharged aldermen in Parliament, etc.', The Aldermen of the City of London: Temp. Henry III - 1912 (1908), pp. 317-328. URL: http://www.british-history.ac.uk/report.aspx?compid=67225 Date accessed: 10 March 2014. Add to my bookshelf
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DISCHARGED ALDERMEN IN PARLIAMENT. SUMMARY OF THE ALDERMANIC REPRESENTATION IN PARLIAMENT, 1640–1906. VOTES OF ALDERMEN OF LONDON AND OTHER CIVIC PERSONAGES IN PARLIAMENT. MAYORS AND LORD MAYORS OF LONDON IN PARLIAMENT. Mayors. Lord Mayors. SHERIFFS OF LONDON IN PARLIAMENT. THE "FATHERS OF THE CITY" IN PARLIAMENT. Footnotes
I have not included in the notices of Aldermen who served in Parliament some (chiefly in the Commonwealth period), whose connection with the Court of Aldermen was little more than nominal, inasmuch as they were discharged from their Aldermanries, either immediately or within a few weeks of their elections. These are—
Sir William Herrick [Farringdon Without, May, 1605] Leicester, Oct.-Dec., 1601, 1605–1611, 1621–1622.
Sir Baptist Hicks [Bread Street, November, 1611] Tavistock, 1620–1622; Tewkesbury, 1624–1628.
Robert Bateman [Cordwainer, June, 1629] Weymouth, March-June 1614 (London, 1620–1622, 1624–1626).
*Thomas Hussey [Vintry, July, 1645] Whitchurch, 1645–1653; Andover, 1656–1658.
Thomas Witherings [Bishopsgate, August, 1649] Morpeth, March-May, 1640.
Edmund Harvey [Dowgate, March, 1650; Farringdon Without, June, 1653] Great Bedwin, 1646–1653, 1659–1660; Middlesex, 1654–1656; Suffolk, 1656–1658.
Anthony Bedingfield [Langbourn, July, 1650] Dunwich, 1640–1648.
Thomas Rich [Bridge, September, 1650] Reading, April-December, 1660.
Theophilus Biddulph [Bread Street, July, 1654] (London, 1656–1658, January-April, 1659;) Lichfield, 1661–1679.
*Philip Holman [Walbrook, August, 1651] Northamptonshire, January-April 1659.
*Reginald Grymes (or Grahme) [Vintry, August, 1651] Leominster, 1661–1679.
John Cutler [Bread Street, August, 1651] Taunton, 1679–1680; Bodmin, 1690–1693.
John Stone [Bridge, September, 1651] (London, July-December, 1653), Cirencester, 1654–1655, 1656–1658. January-April, 1659.
Henry Pickering [Bishopsgate, September, 1651] Cambridgeshire, 1654–1655, 1656– 1658, January-April, 1659.
*John Barker [Bread Street, September, 1651] Ilchester, January-April, 1659.
Alexander Bence [Walbrook, May, 1653] Aldeburgh, 1640–1653; Suffolk, 1654–1655.
*James Baker [Castle Baynard, November, 1657] Shaftesbury, January-April, 1659, April-December, 1660.
Martin Noell [Aldersgate, December, 1657] Stafford, 1656–1658, January-April, 1659.
John Jolliffe [Bishopsgate, September, 1658] Heytesbury, April-December, 1660, 1661–1679.
William Strode [Vintry, February, 1661] Ilchester, 1646–1648.
Nicholas Delves [Vintry, April, 1661] Hastings, January-April, 1659, April-December, 1660.
John Jefferies (or Jeffreys) [Bread Street, June, 1661] Brecknockshire, 1661–1662; Brecon borough, 1679–1681, 1685–1687.
Thomas Lewis [Broad Street, June, 1661] Wycombe, 1679–1681.
Thomas Turgis [Farringdon Without, July, 1661] Gatton, January-April, 1659, 1660–1681, 1685–1687, 1689–1702.
John Breedon [Farringdon Without, July, 1667] Reading, June-September, 1685.
Peter Delannoy (or Delaney) [Vintry, February, 1668] Southwark, 1656–1658.
John Morris [Cheap, May, 1669] Bletchingley, 1679–1681.
*John Man [Cheap, June, 1669] Weymouth and Melcombe Regis, 1673–1679.
Sir Henry Ashhurst [Vintry, October, 1688] Truro, February-March, 1681, 1689–1695; Wilton, 1698–1700, 1701–1702.
The identification in the case of each of the Aldermen marked * with Members of Parliament bearing the same name is tentative and not definitely established.
The following table shows the fluctuation in the number of Aldermen in Parliament since the meeting of the Long Parliament in November, 1640.
Subjoined is a list of the votes of Aldermen of London and other civic personages in Parliament in the most important divisions of the last two centuries.
[The names in Italics denote those who were not Aldermen at the time of the votes recorded, but had held that position earlier or attained it at a later period. Those in smaller type denote civic personages other than Aldermen]
The following is a complete list of the chief magistrates of the City of London, who have served in Parliament during any portion of their years of office.
Those marked * were re-elected for their former seats at General Elections, occurring during their respective Mayoralties.
The following is a complete list of the Sheriffs of London who have served in Parliament during any portion of their respective years of office. Those who were Aldermen during the whole or any portion of their respective Shrievalties are printed in the ordinary type, others are printed in Italics, those who subsequently became Aldermen being distinguished by a *:—
[At the General Election of 1780, Sheriff-elect John Kirkman was returned for the City of London but he died on September 15, before the date for entry into office.]
The following Sheriffs were unsuccessful candidates for parliamentary constituencies during their respective terms of office:
The following Members of Parliament were elected Sheriffs at the dates indicated, but did not accept the office:
The "Fathers of the City" who held seats in Parliament after attaining to and during the continuance of their seniority in the Court of Aldermen were the following:
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Bishop Nehru Details Kendrick Lamar Meeting, Reveals MF DOOM Project
Exclusive: Bishop Nehru talks about why it was significant to receive praise from Kendrick Lamar and says he has an upcoming project with MF DOOM.
Soon after a video surfaced of Bishop Nehru receiving praise and advice from Kendrick Lamar, Nehru spoke with HipHopDX about how the situation came to be.
"I was chilling after the [kendrick Lamar] show at Williamsburg Park [in New York] in my trailer," Nehru said in an exclusive statement to HipHopDX. "Then I went outside. Kendrick's manager was outside too and [he] told me to follow him. Went to the TDE trailer and was just chilling there for a bit."
Nehru said Kendrick Lamar is one of very few artists that he listens to.
"It was cool knowing one of the very few artists I listen to listens to me as well," Nehru said. "Kendrick's a real chill dude."
Kendrick Lamar's advice and praise for Nehru can be seen below via FUSE News.
While his appreciation for Kendrick Lamar is apparent, Nehru is also set to work with another notable emcee.
"Next up I have a project with MF DOOM coming up," Nehru said to HipHopDX. "That's what's in the works right now."
The Nehru and DOOM collaborative project was announced August 9. Details on the collection are scarce at the moment, thought it has been reported that the effort will be released via LEX Records.
RELATED: Kendrick Lamar Gives Praise & Advice To Bishop Nehru
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Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment
Cancer Cell, Volume 15, Issue 6, 2 June 2009, Pages 527-538
Denise A. Chan, Tiara L.A. Kawahara, Patrick D. Sutphin, Howard Y. Chang, Jen-Tsan Chi and Amato J. Giaccia
SummarySustained angiogenesis, through either local sprouting (angiogenesis) or the recruitment of bone marrow-derived cells (BMDCs) (vasculogenesis), is essential to the development of a tumor. How BMDCs are recruited to the tumor and their contribution to the tumor vasculature is poorly understood. Here, we demonstrate that both IL-8 and angiogenin contribute to the complementary pathways of angiogenesis and BMDC mobilization to increase tumor growth. These two factors are regulated by PHD2 in a HIF-independent but NF-κB-dependent manner. PHD2 levels are decreased in human cancers, compared with corresponding normal tissue, and correlate with an increase in mature blood vessels. Thus, PHD2 plays a critical role in regulating tumor angiogenesis.
Summary | Full Text | PDF (1695 kb) - Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
Cell, Volume 145, Issue 5, 27 May 2011, Pages 732-744
Weibo Luo, Hongxia Hu, Ryan Chang, Jun Zhong, Matthew Knabel, Robert O'Meally, Robert N. Cole, Akhilesh Pandey and Gregg L. Semenza
SummaryThe pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the PKM2 gene. PKM2, but not PKM1, alters glucose metabolism in cancer cells and contributes to tumorigenesis by mechanisms that are not explained by its known biochemical activity. We show that PKM2 gene transcription is activated by hypoxia-inducible factor 1 (HIF-1). PKM2 interacts directly with the HIF-1α subunit and promotes transactivation of HIF-1 target genes by enhancing HIF-1 binding and p300 recruitment to hypoxia response elements, whereas PKM1 fails to regulate HIF-1 activity. Interaction of PKM2 with prolyl hydroxylase 3 (PHD3) enhances PKM2 binding to HIF-1α and PKM2 coactivator function. Mass spectrometry and anti-hydroxyproline antibody assays demonstrate PKM2 hydroxylation on proline-403/408. PHD3 knockdown inhibits PKM2 coactivator function, reduces glucose uptake and lactate production, and increases O2 consumption in cancer cells. Thus, PKM2 participates in a positive feedback loop that promotes HIF-1 transactivation and reprograms glucose metabolism in cancer cells.
Summary | Full Text | PDF (2007 kb) - Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes
Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes
Trends in Biochemical Sciences, Volume 38, Issue 1, 1 January 2013, Pages 3-11
Brian W. Wong, Anna Kuchnio, Ulrike Bruning and Peter Carmeliet
AbstractOxygen-sensing prolyl hydroxylase domain enzymes (PHDs) target hypoxia-inducible factor (HIF)-α subunits for proteasomal degradation in normoxia through hydroxylation. Recently, novel mechanisms of PHD activation and function have been unveiled. Interestingly, PHD3 can unexpectedly amplify HIF signaling through hydroxylation of the glycolytic enzyme pyruvate kinase (PK) muscle isoform 2 (PKM2). Recent studies have also yielded insight into HIF-independent PHD functions, including the control of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking in synaptic transmission and the activation of transient receptor potential cation channel member A1 (TRPA1) ion channels by oxygen levels in sensory nerves. Finally, PHD activation has been shown to involve the iron chaperoning function of poly(rC) binding protein (PCBP)1 and the (R)-enantiomer of 2-hydroxyglutarate (2-HG). The intersection of these regulatory pathways and interactions highlight the complexity of PHD regulation and function.
Abstract | Full Text | PDF (1431 kb) - …more
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Copyright © 2005 Elsevier Inc. All rights reserved.
Molecular Cell, Volume 17, Issue 4, 503-512, 18 February 2005
Add/View Comments (0)OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α
Jin Hyen Baek1, 3, Patrick C. Mahon1, 3, Jane Oh1, Brian Kelly1, Balaji Krishnamachary1, Mia Pearson1, Denise A. Chan2, Amato J. Giaccia2 and Gregg L. Semenza*, 1,
1 Institute for Cell Engineering, McKusick-Nathans Institute of Genetic Medicine and Department of Pediatrics, Department of Medicine, Department of Oncology and Department of Radiation Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA
2 Program in Cancer Biology, Department of Radiation Oncology, Stanford University, Stanford, CA 94305 USA
3 These authors contributed equally to this work.
- Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis in metazoan species. HIF-1 mediates changes in gene transcription in response to changes in cellular oxygenation. The half-life of the HIF-1α subunit is determined by oxygen-dependent prolyl hydroxylation, which is required for binding of the von Hippel-Lindau protein (VHL), the recognition component of an E3 ubiquitin ligase that targets HIF-1α for ubiquitination and degradation. Here, we demonstrate that OS-9, the protein product of a widely expressed gene, interacts with both HIF-1α and HIF-1α prolyl hydroxylases. OS-9 gain-of-function promotes HIF-1α hydroxylation, VHL binding, proteasomal degradation of HIF-1α, and inhibition of HIF-1-mediated transcription. OS-9 loss-of-function caused by RNA interference increases HIF-1α protein levels, HIF-1-mediated transcription, and VEGF mRNA expression under nonhypoxic conditions. These data indicate that OS-9 is an essential component of a multiprotein complex that regulates HIF-1α levels in an O2-dependent manner.


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Kroy Biermann has officially adopted Kim Zolciak's daughters Brielle and Ariana, E! Online reports.
Brielle, 16, and Ariana, 12, are the Real Housewives of Atlanta star's children from a previous relationship. Zolciak, 35, and NFL player Biermann, 27, wed in 2011 when their first son together, Kroy Jr., was 6 months old. They welcomed another boy, Kash, in 2012. Zolciak recently revealed on the Don't Be Tardy finale that she is pregnant with her fifth child.
Season 1, Episode 9 Bravo has the hottest seat in the house for Kim Zolciak's extravagant wedding in a new docu-series titled "Don't Be Tardy for the Wedding." It's been just a year since the Bravo cameras captured Kim's fortuitous meeting with Kroy Biermann, Defensive End for the Atlanta Falcons. Each thirty minute episode will follow the adventures of Kim preparing for her wedding on the lucky date of 11/11/11. With less than 2 months to plan, she enlists celebrity event planner Colin Cowie to help design a dream wedding in her brand new multi-million dollar home. The pressure is on as Kim rushes to find a dress, lose remaining baby weight and cosmetically enhance trouble spots. With the date quickly approaching, problems mount - her invitation is leaked to the press and her mother refuses to attend the wedding. Still, Kim is determined to marry Kroy and won't let anything ruin her perfect day.
Season 1, Episode 5 Kim Zolciak tries to figure out the bathroom situation and tries to talk to her mom.
Season 1, Episode 5 Kim Zolciak is not looking forward to this fitting with her mom after what happened last time.
Kim Zolciak confirmed that she is pregnant with her fifth child on the Tuesday finale of Don't Be Tardy.
"How exciting is that, love muffin?" Zolciak said on the show, hugging her husband Kroy Biermann. read more
Former Real Housewives of Atlanta star Kim Zolciak is pregnant with her fifth child, In Touch reports.
Bravo is giving The Real Housewives of Orange County star Tamra Barney her own spin-off, The Wrap reports.
The new series will follow... read more
The Real Housewives of Atlanta's Kim Zolciak has had no problem putting her personal life — birth, wigs, catfights and all — on television. But for the first time, she's nervous about airing a very emotional battle she's having at home.
"I am not speaking to my parents," she tells TVGuide.com. "I've shared a lot of my life in front of the cameras ... and this is the first situation I've had to deal with publicly that is too close to home."
Who is NeNe Leakes' celebrity crush? Bravo stars play our cocktail shaker question roulette
On the season premiere of Don't Be Tardy... (Tues, 9/8c on Bravo), viewers will learn why Zolciak still hasn't spoken to her mom since their argument at her wedding. But despite intense fight with her parents, Zolciak promises plenty of laughs as she and husband Kroy Biermann welcome baby boy Kash Kade into a family that also consists of 14-month-old KJ and Kim's two daughters from a previous marriage, 16-year-old Brielle and 11-year-old Ariana. Plus: What does the outspoken blonde tell us she wishes she had said on Sunday night's Housewives reunion?


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1. Divide the class into teams and play a game of Pictionary using the key terms and concepts. Students have to draw out the terms and the highest score wins.
2. For younger students, create a timeline showing the differences in the evolution of the horses' feet. The students' fingers can be toes with successive pictures of four-three-two-one hoof showing all the fingers balled up in a fist.
3. Compare the horses' need to adapt by looking at human teeth and their purposes. For example, molars vs. incisors.
4. For older students, divide the class into groups and have them focus on one stage of the horse evolution process. Each group can then present to the class their findings on its characteristics and differences in a successive order.
5. In a similar way, the students can be divided up and asked to present how horses have affected Travel, Trade, War, Work, and Spirituality.


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Hi im so bored so comment plz.(Backround:"let her be bored its not like she entertains any of you") HEY DONT ... • 0 Comments
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Konnichiwa,i love anime and manga.I also love to draw and write.I have to admit im a geek,but im also a Gleek.I love glee so much lol.I LOVE JAPAN SO MUCH<3,ITS THE BEST PLACE IN THE WORLD X3.Any way,I totally love vampire knight,meru puri and anything by hino matasuri(mangas).i Love naruto,bleach,and most animes, and i love speaking japanese.In my house speaking japanese is weird ,which i THINK NOT.I<3 MUSIC(ALL MUSIC).I love(<3)cats and also i love shjo beat..doesnt mean i dont like the others...0_0.Anyways im funny(so i was told),and funny and short..and..and..um?? *Stare*umm idk right now but ill get back to this.I hate i mean I HATE *scary music* NOTHING..*DRAMATIC*..i got you (didnt i 20% right).Also please call me Sarah-San or Chan please,why you ask because it makes me feel Loved!!....Anyway...Girlys out there..*Embrassed*>///<.um LETS ALL BE FRIENDS! (also boys but if i had said that then i would really blush).ok thats it any questions ask ill answer ok BYE BYE.:) i will edit this again and again and again ok X3
Hi im so bored so comment plz.(Backround:"let her be bored its not like she entertains any of you") HEY DONT LISTEN TO HIM WHAT HAS EVER DONE(Silence) SEE ! (Backround:' i have done lots of things") ILL KILL YOU (Backround:" hehe you cant even see me") UGH i hate it when your..your(Backround:" come on say it, say it when im r.i.g.h.t come on") -_- i hate it when your WRONG(Backround:"-_- come on all u had to say was right") see but you are NOT right i have super vision so i can see you HAHAH(in my mind:" wahhhhh i cant see him") (Backround:" aa so then touch me") ok I WILL *ARM SWAYING UP AND DOWN TRYING TO TOUCH HIM/HER* -_- (Backround:" see im right") ok before i EPICLY EXPLODE ARE YOU A DUDE OR A GIRL(Backround:" -_- for real im A GAY") O_O .pff....HAHAHAHHAAHAHHA(Backround:" whats so funny") YOU SAID..HAHAHAHAHA YOU SAID YOUR a gay.PF AHAHAAHAAH(Backround:" Hey i meant to say guy") AHAHAHHH..hh ok sorry GAY HAHAHAH(Backround:" hey its not th") HAHAHAHAAHAHAHAHAHAHAHAAHHAHAAHAH*ON FLOOR ROLLING,TEARING* (Backround:"ok thats it bye people sorry for her rudeness have a GREAT day :) *hears laughing"GAY hhahahahh* im mad now SHUT THE HELL UP>_<) whispers*heheheh Gay*(Backround:"ughh shut up upujpupupupupupup) hes mad >//< hehe bye now
I love ur background :)
How have you been ???
thanks for the info ill check it out !!!
haha yes it is ^_^ its my fav
btw the cat is cute
hi i had a question for you what is meru puri about i happened to see it on your profile into and was wondering what it was about
haha thanx ^_^ vampire knight is the best so how ya been
OH MY GOD i just realized i could have used the abbreviation..-_- I AM SO SWORRY I HAVEN'T BEEN ONLINE ITS JUST THAT SO MUCH ANIME HAS DEPRESSED ME LIKE IN CLANNAD *sinks into depression* SWORRY!!
love the back ground , super cute griel is one of my favs !!!
hey whatcha been up to
And y r u so happy ???
Omg HIYA :)) H
thanks! i like your background!
Cheers, gotta say your background is feakin' awesome!
hey how ya been ^_^
aww cute black butler layout
i am so UNACTIVE OMG I NEED MEDICAL HELP!!T0T
WElcome and HEY!
Heyy Whats up?!
haia! thnx soooo much 4 add X3 hehe i also hv ur profile pic XD (nice pic btw)
*Huff* im *huff*..Im..*Huffff* IM WAS NOT ABLE TO COME ON FOR A WHILE OK...0_0 IM HAVE TO GO..*i Died of Tiredness*
Thanks for the add and I love your background picture :D
Ahh Sarah-san Thanks (^o^)
welcome and how can i not add a ouran LOVER!
Thank you for the ad =]
Thanks for all the COMMENTS! LETS COMMENT SO MORE YAY!*Dances and jumps*
ty 4 the add hahaha ^^)
thanks for the add, basically anybody on here can b your online bff everyone is really friendly here if u have MSN this is a good place to start http://www.ani.me/community/forums/thread/574/
Welcome!!! haha i read your first comment and i want to be your BFF!!! lol *whispers* im a girl dont be fool with my profile pic!! hahaha!! :P
Carmalldansen! lol love your background and thanks for the add :D
hi thanx for the add :)
Thanks for the add also your background picture is cute as heck ahah so is you profile one
hi welcome to ani.me
Welcome to Ani.me! We hope you like our site and feel free to let us know what you think of it or things you would like to see on it through the feedback button on the right side of the page! If you haven't yet, sign up for one of our contests! So Sarah-san what do you usually like to write about?
hi welcome to ani.me :) enjoy the site great pic XD
welcome! i love your profile pic :D
Welcome to ani.me, i hope you enjoy the site as much as i do (im new as well) btw awesome profile pic =D
Well welcome to ani.me I hope you'll be able to find that online BFF soon. I love your profile pic :)


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Surveying theories and philosophies of mathematics education
Bharath Sriraman
Dept. of Mathematical Sciences
The University of Montana
Lyn English
Queensland University of Technology
Brisbane, Australia
Any theory of thinking or teaching or learning rests on an underlying philosophy of knowledge. Mathematics education is situated at the nexus of two fields of inquiry, namely mathematics and education. However, numerous other disciplines interact with these two fields, which compound the complexity of developing theories that define mathematics education. We first address the issue of clarifying a philosophy of mathematics education before attempting to answer whether theories of mathematics education are constructible.
Keywords: philosophy of mathematics; philosophy of mathematics education; theory of knowledge; theory of mathematics education
AMS Subject Classification: 97


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Dream 101 keeps NBA players on their toes
Smiley N. Pool, Staff
September 29, 2013
For just a moment, as Hakeem Olajuwon made his way through Houston streets to the start of Rockets training camp, he flashed back to all those years and all those practices and wondered what he was doing.To continue reading this story, you will need to be a digital subscriber to HoustonChronicle.com.
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DW SM1207 Delta Ball Bearing Hinge
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You must earn 10,000 points to post other members' whiteboard
Welcome to the club...You and I are on the bottom of Consecutive Days leader board. GREAT JOB!!!... CONGRATS Consecutive Days: 324 !!! I am at 267 DAYS!! HAPPY NEW YEAR MY NEWEST GB...AL
Dang it Susan. One day, I look and you haven't gotten there, and the next time, you are passed there. Anyway, let me give you A BIG CONGRATS on your 301 Cons Days!! Keep up the good work. David...........QQ
Congratulations on having the perseverance to post for 300 consecutive days. Have a Wonderful weekend! Warren :)
TuanCanCook is celebrating her b'day today, drop by her wb with wishes. Happy posting !!
Wishing everyone a New Year filled with New Hope, New Joy and New Beginnings. God Bless you through out 2014... Have an unforgettable New Year!
Hey Susan, let me give you A BIG CONGRATS on your busting into the .9 mill. in points!! Hope you have a very Happy New Year also.Keep up the good work. David...........QQ
Congratulations on having the dedication to post for 250 consecutive days. Keep up the Good Work. Warren 8-)
Good take on the black box in autos (should reduce insurance rates, you said). Unfortunately, I doubt the insurance guys would actually pass on the savings to us.
Hey Suan, let me give you A BIG CONGRATS on your 200 Cons Days!! When most GBs lost their CD, most don't make it back to their 90th, and less of them make it to their 200th. BUT, you have done it!!! Keep up the good work. Your Buddy, David..........QQ
Welcome to Colorado! Here's hoping your stay is pleasant and as eventful as you had hoped for. The weather and road conditions are continually changing. If you are traveling to the high country or any other part of Colorado, then please visit: http://www.cotrip.org for the latest road conditions and webcams. It's the "Bomb", and you'll find it useful while here. Safe and warm travels, and best to you in 2013 and beyond.


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Nectar restaurant serves contemporary seasonal cuisine using quality local and organic products when ever possible. Our small changing menu and wine list reflect the best of the season prepared with a French Mediterranean flair.
Nectar Restaurant 1000 Delta Ave. Cincinnati, OH 45208 513.929.0525
Reservations Welcome
Directions | Sample Menus | Dinner Club | Nectar@Home | Reviews | About Us


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New Arrivals
Washed Stripe Sunset Hues Vest
Extended Sizes In Select Colors
In love with lavender: it adds a soft pop to the striped, duster sweater vest. The flared collar flatters and frames the face.
- Wide-ribbed hem.
- Length: 30" to 34".
- 75% acrylic, 25% wool.
- Hand wash. Imported.


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THE Eleventh ANNUAL Young Authors Event
Running from January 27th through March 8th, 2014
Kids from grades K-12 are invited to submit an original work of fiction or non-fiction to our Young Authors Event. The library will bind 2 copies of the book, returning one copy to the writer and keeping one copy on our shelves so others can view it. Check out our shelves for past submissions to see what it's all about! The library will host a party on April 15 to honor those who participated. See the rules and guidelines below:
Borrowed Items are Due at Closing.
Contact Us
295 East Center Street Nazareth, PA 18064 Map It!
610-759-4932 phone 610-759-9513 fax www.nazarethlibrary.org email@example.com


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- Bob Vila TV Shows >
- Modern Colonial > Episode 11: Interior Door Installation and Plan Modifications
Shimming, Centering, and Hanging a Door
The dining room paneling is almost finished, and Bob talks with Ben LaRochelle from Drummond Designs to learn how they fabricated the design plans from architectural models, stock plans, and lot requirements using a laptop computer.
Upstairs, Bob Ryley is hard at work in the master bedroom, beginning with a door installation leading into the master bathroom. Jim Daniels from Woodport is on hand to discuss the features of the door with Bob. Finally, Ryley works on trimming out the doorframe and windows.
Upstairs, Bob Ryley is hard at work in the master bedroom, beginning with a door installation leading into the master bathroom. Jim Daniels from Woodport is on hand to discuss the features of the door with Bob. Finally, Ryley works on trimming out the doorframe and windows.
- Part 1: Custom Home Design Using Computer Software
- Part 2: Hanging an Engineered Wood Six-Panel Door
- Part 3: Shimming, Centering, and Hanging a Door
- After roughing the door into place, Ryley checks to make sure it is centered and temporarily secures it using plywood blocks. Next, he checks the margin around the perimeter of the door to make sure each side is even. Shims are added to each side to create a solid wood backing between the jamb and the studs that frame the door opening. Final adjustments are made with the door closed; the last shim is installed at the striker plate before the door is permanently secured to the framing.
- Part 4: Installing Interior Window Casings and Sill
This project focuses on the construction of a Colonial-style home built with both history and the future in mind. While the 4-bedroom, 4-bath home will have a traditional exterior and interior detailing, the plan will suit the needs of a modern family, including easy-maintenance fireplaces, a great room, master suite, sun room, 3-car garage, and a large walk-out basement with plenty of room for recreation and indoor/outdoor living.
Also from Modern Colonial
Episode 3 - Shingles and Windows
The roof structure begins to take shape in this episode, which focuses on the asphalt shingle installation. The crew takes us through the steps of the shingling process, from the flashing and underlayment, to the precise layout of each course.

 On the ground, Ryley and framing contractor Kevin Parquette are installing windows. Also, Bob explores the home designs of the firm of noted 20th-century architect Royal Barry Wills, an avid proponent of preserving historical accuracy and proportion in designing elegant, sensible houses for modern living. -
Episode 4 - Radiant Heating System and Ductwork
A new radiant heating system is being installed in the basement in this episode. Bob and Erling Andersen discuss the features of the "Boiler Room in a Box", a new compact, energy-efficient way to heat your home. Upstairs, Bob gets a look at how HVAC ductwork is assembled and run through the attic to an air handler. Finally, Bob takes a tour of a historic doctor's office in the scaled-down colonial Julia Wood House in Falmouth, MA. -
Episode 5 - Gas Fireplaces and Cedar Shingles
A Heat-N-Glo gas fireplace unit is being installed in this episode, one of several throughout the house. Bob tours the showroom to see the different models available and understand how they work, then meets the crew from The Ironhouse in Hyannis, MA, back on site to help set up a unit in the project house.

 Around back, Eastern White Cedar sidewall shingles are ready to be installed. Keith Ball from Maibec is on site to talk with Bob about the correct installation technique. Finally, Bob takes a trip to Canada to see how they're milled. -
Episode 8 - Garage Door and Generator Installation
Episode 9 - Wood Floor Installation
Episode 10 - Interior Wall Panels and Flooring
Episode 12 - Interior Woodwork
Episode 13 - Exterior Landscaping
Episode 14 - Mechanical Systems and Basement Refinishing
Episode 15 - Mechanical Systems and Interior Finishing
Episode 16 - Kitchen Cabinetry and Countertops
Episode 17 - Bedroom Amenities
Episode 18 - Interior Decorating Tour
Episode 19 - Workshops and Woodworking
Episode 20 - Classic Interiors and Cabinet Install
Episode 21 - Wood Floor Finishing
Episode 22 - Interior Craftwork
Episode 23 - Interior Design Projects
Episode 24 - More Interior Design Projects
Episode 25 - Appliance Installation and Furniture Making


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Found November 13, 2011 on
Inside the Bills:
Kyle Williams agent tweeted earlier this week that his client had successful surgery. Here are a few more details.
Buffalobills.com has confirmed that Williams had bone spurs on his heel, which can be painful enough in their own right. Those bone spurs were then pushing on his Achilles tendon. The bone spurs were so painful that Williams had a hole cut in the back of every one of his left-footed cleats to make the pain more bearable while he was still playing.
Williams played with a foot problem last season and was able to perform at a Pro Bowl level. It's unknown if this foot problem was the same as the one that plagued him last year, but after three weeks in an immobilizer boot the problem was not alleviated.
So Williams had surgery to have the bone spurs removed and get his Achilles back in line. Head coach Chan Gaily told Buffalobills.com that Williams is expected to be fully recovered in plenty of time for the 2012 season and back to his normal explosive, disruptive self on Buf...
Original Story:
Bills lose Eric Wood for season
David Nelson Grabs TD Then Gives Ball to Girlfriend Who Is a Cowboys Cheerleader (Video)
Lindell unlikely to return
Gailey's QB approach unchanged
The DONE-O-METER: Buffalo Bills Are Fading
Game ball: Cowboys 44, Bills 7
Fred said Bills will make playoffs
Bills K Lindell out against Cowboys (AP)
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556 results for "heath bell"
Heath Bell #13 RP
ERA W-L SV SO WHIP 4.11 5-2 15 72 1.37 FANTASY OWN(WK+/-) AVG DRAFT 4.7(-0.4) 260.0 Next Game: Pirates vs. Rays Saturday 3/8 1:05 PM ET -
Tampa Bay Rays bring in Grant Balfour
Jerry CrasnickFree-agent closer Grant Balfour reached agreement on a two-year, $12 million deal with the Tampa Bay Rays on Thursday.
Story | Conversation | January 23, 2014 -
Jarrod Saltalamacchia happy to join hometown Miami Marlins
Jarrod Saltalamacchia hopes to stick around with the Miami Marlins.
Story | Conversation | December 09, 2013 -
Tuesday's priority: Upgrade bullpen, 'd'
ESPN Stats & InformationIt was a very, very busy Tuesday in baseball and the priorities for the teams involved in making moves revolved around two areas- relief pitching and defense. The Tigers made the biggest transaction of the day so far, signing free agent closer Joe...
Blog | December 03, 2013 -
A wild and crazy day of transactions
David SchoenfieldTake a deep breath. If Tuesday's slew of transactions is any sign of what will happen at next week's winter meetings, then be prepared for a great week of rumors, deals and signings. As for Tuesday, so much happened that I'm starting to believe the R...
Blog | December 03, 2013 -
Photo results for "heath bell"
Colorado Rockies v Arizona Diamondbacks
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Arizona Diamondbacks v Los Angeles Dodgers
September 09, 2013 -
San Francisco Giants v Arizona Diamondbacks
September 01, 2013 -
BESTPIX Arizona Diamondbacks v Philadelphia Phillies
August 25, 2013
Tampa Bay Rays acquire Ryan Hanigan, Heath Bell in three-team tra...
Catcher Ryan Hanigan and reliever Heath Bell are eager to try to help the Tampa Bay Rays get back to the playoffs.
Story | Conversation | December 03, 2013 -
Rapid Reaction: Mets 9, D-backs 5
Adam RubinPHOENIX -- Jonathon Niese struggled in his first major league start in more than seven weeks but nonetheless contributed six innings and earned the victory Sunday afternoon. Andrew Brown's three-run homer in the seventh against right-hander Will H...
Blog | August 11, 2013 -
Rapid Reaction: D-backs 5, Mets 4
Adam RubinPHOENIX -- The Mets' charge toward second place had a hiccup Friday night in the opener of a four-city western swing. The Arizona Diamondbacks produced a 5-4 walk-off win at Chase Field as Paul Goldschmidt produced a one-out homer against Scott At...
Blog | August 10, 2013 -
Series preview: Mets at Diamondbacks
Adam RubinAssociated Press, USA TODAY SportsThe Mets face (l to r) Patrick Corbin, Brandon McCarthy and Zeke Spruill this weekend at Chase Field.METS (52-60, third place/NL East) vs. ARIZONA DIAMONDBACKS (58-55, second place/NL West) Friday: RHP Jeremy Hefn...
Blog | August 09, 2013 -
Video results for "heath bell"
Columbus NFTC RB/LB One-On-Ones
May 07, 2012
Closer Report: Midseason awards
Eric KarabellBack in March, there was little indication fantasy owners would need to pay attention to -- or own -- the likes of Kevin Gregg, Koji Uehara and Francisco Rodriguez, but here we are days before the All-Star break and those guys are certainly a whole l...
Blog | July 12, 2013 -
Is Derek Jeter worth adding right away?
Eric KarabellThe New York Yankees will welcome back future Hall of Famer Derek Jeter to their lineup Thursday afternoon, and not a moment too soon. No offense to Jayson Nix and pals, but Yankees shortstops weren't helping the team much offensively, featuring a lo...
Blog | July 11, 2013 -
Dodgers keep the heat on Arizona
Mark SaxonAt least as long as the San Francisco Giants continue to struggle, the best rivalry in the NL West has shifted a bit south and a bit east. And, for the first time in years, the Los Angeles Dodgers gained the upper hand. The Arizona Diamondbacks bl...
Blog | July 11, 2013 -
Rapid Reaction: D-backs 5, Mets 4 (15)
Adam RubinNEW YORK -- The New York Mets' Fourth of July festivities included two long balls to erase extra-inning deficits. It still ended up a dud. Anthony Recker had a game-tying, two-out solo homer in the 13th against ex-Met Heath Bell, then Kirk Nieuwen...
Blog | July 04, 2013 -
Rapid Reaction: Mets 5, D-backs 4 (13)
Adam RubinNEW YORK -- Catcher Miguel Montero could not hold onto the ball. The Arizona Diamondbacks eventually could not hold on for the win, either. Cody Ross opened the 13th inning with a homer against David Aardsma, but Andrew Brown's two-run single in t...
Blog | July 02, 2013 -
Series preview: Mets vs. Diamondbacks
Adam RubinAssociated Press/Getty ImagesThe Mets face two southpaws to open a four-game series vs. Arizona: Wade Miley and Patrick Corbin.METS (33-45, fourth place/NL East) vs. ARIZONA DIAMONDBACKS (42-39, first place/NL West) Monday: RHP Shaun Marcum (1-9, ...
Blog | July 01, 2013 -
J.J. Putz of Arizona Diamondbacks activated from disabled list
The Arizona Diamondbacks have reinstated closer J.J. Putz from the 15-day disabled list and optioned right-hander Zeke Spruill to Triple-A Reno.
Story | Conversation | June 29, 2013 -
Bits: Nelson Cruz quietly producing
Eric KarabellTexas Rangers outfielder Nelson Cruz fell to the 13th round, on average, in ESPN live drafts prior to this season, which seemed a bit strange, but it made him a nice bargain. Sure, there's outfield depth this season and Cruz has had trouble staying o...
Blog | June 18, 2013


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Book Description:Natsume Soseki (1867-1916) was the foremost Japanese novelist of the twentieth century, known for such highly acclaimed works as Kokoro, Sanshiro, and I Am a Cat. Yet he began his career as a literary theorist and scholar of English literature. In 1907, he published Theory of Literature, a remarkably forward-thinking attempt to understand how and why we read. The text anticipates by decades the ideas and concepts of formalism, structuralism, reader-response theory, and postcolonialism, as well as cognitive approaches to literature that are only now gaining traction. Employing the cutting-edge approaches of contemporary psychology and sociology, Soseki created a model for studying the conscious experience of reading literature as well as a theory for how the process changes over time and across cultures. Along with Theory of Literature, this volume reproduces a later series of lectures and essays in which Soseki continued to develop his theories. By insisting that literary taste is socially and historically determined, Soseki was able to challenge the superiority of the Western canon, and by grounding his theory in scientific knowledge, he was able to claim a universal validity.
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Bouchal, Jan and Baumforth, Karl R N and Sváchová, Michaela and Murray, Paul G and Angerer, Erwin von and Kolár, Zdenek (2005) Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines. The Journal of pharmacy and pharmacology 57 (1), pp. 83-92.
Bouchal, Jan and Kolár, Zdenek and Mad'arová, Jana and Hlobilková, Alice and Angerer, Erwin von (2002) The effects of natural ligands of hormone receptors and their antagonists on telomerase activity in the androgen sensitive prostatic cancer cell line LNCaP. Biochemical Pharmacology 63 (6), pp. 1177-81.


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Virtual Synth is an experimental synthesizer for your iPhone/iPod touch. You can generate sine tones and square waves from a wide range of frequencies. Experiment with different grid positions to generate modulating signals with different beat frequencies. A minimal control interface and engaging graphics make it a lot more fun to use.
Touch to create an instrument anywhere on the grid. The numerical labels display frequency values. You can select a different instrument/frequency and tap on an existing instrument to change it. The beat frequency for modulating waves increases diagonally. Tap with two fingers at any time to remove all instruments.
X: to show/hide frequency labels.
+/-: to toggle adding or removing instruments.
F: to show/hide slider display to change frequency range.
Every time you move the slider the grid updates with a new range of available frequencies. Making it convenient to have instruments of a wide range of frequencies playing at the same time. After adding an instrument the frequency label doesn't change unless you remove it or replace it with another instrument.
sin: to add a sine tone.
mod: to add a modulating signal.
sqr: to add a square wave.
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