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Growth retardation versus overgrowth: Silver-Russell syndrome is genetically opposite to Beckwith-Wiedemann syndrome Trends in Genetics, Volume 24, Issue 4, 1 April 2008, Pages 195-204 Thomas Eggermann, Katja Eggermann and Nadine Schönherr Abstract Human growth is a complex process that requires the appropriate interaction of many players. Central members in the growth pathways are regulated epigenetically and thereby reflect the profound significance of imprinting for correct mammalian ontogenesis. In this review, we show that the growth retardation disorder Silver-Russell syndrome (SRS) is a suitable model to decipher the role of imprinting in growth. As we will show, SRS should not only be regarded as the genetically (and clinically) opposite disease to Beckwith-Wiedemann syndrome, but it also represents the first human disorder with imprinting disturbances that affect two different chromosomes (i.e. chromosomes 7 and 11). Thus, a functional interaction between factors encoded by chromosomes 7 and 11 is likely. Abstract | Full Text | PDF (768 kb) |
Relaxation of Insulin-like Growth Factor 2 Imprinting and Discordant Methylation at KvDMR1 in Two First Cousins Affected by Beckwith-Wiedemann and Klippel-Trenaunay-Weber Syndromes The American Journal of Human Genetics, Volume 66, Issue 3, 1 March 2000, Pages 841-847 Maria Pia Sperandeo, Paola Ungaro, Maria Vernucci, Paolo V. Pedone, Flavia Cerrato, Lucia Perone, Stefano Casola, Maria Vittoria Cubellis, Carmelo B. Bruni, Generoso Andria, Gianfranco Sebastio and Andrea Riccio Abstract Beckwith-Wiedeman syndrome (BWS) and Klippel-Trenaunay-Weber syndrome (KTWS) are different human disorders characterized, among other features, by tissue overgrowth. Deregulation of one or more imprinted genes located at chromosome 11p15.5, of which insulin-like growth factor 2 (IGF2) is the most likely candidate, is believed to cause BWS, whereas the etiology of KTWS is completely obscure. We report a case of BWS and a case of KTWS in a single family. The probands, sons of two sisters, showed relaxation of the maternal IGF2 imprinting, although they inherited different 11p15.5 alleles from their mothers and did not show any chromosome rearrangement. The patient with BWS also displayed hypomethylation at KvDMR1, a maternally methylated CpG island within an intron of the KvLQT1 gene. The unaffected brother of the BWS proband shared the same maternal and paternal 11p15.5 haplotype with his brother, but the KvDMR1 locus was normally methylated. Methylation of the H19 gene was normal in both the BWS and KTWS probands. Linkage between the insulin-like growth factor 2 receptor (IGF2R) gene and the tissue overgrowth was also excluded. These results raise the possibility that a defective modifier or regulatory gene unlinked to 11p15.5 caused a spectrum of epigenetic alterations in the germ line or early development of both cousins, ranging from the relaxation of IGF2 imprinting in the KTWS proband to disruption of both the imprinted expression of IGF2 and the imprinted methylation of KvDMR1 in the BWS proband. Analysis of these data also indicates that loss of IGF2 imprinting is not necessarily linked to alteration of methylation at the KvDMR1 or H19 loci and supports the notion that IGF2 overexpression is involved in the etiology of the tissue hypertrophy observed in different overgrowth disorders, including KTWS. Abstract | Full Text | PDF (727 kb) |
Epigenetic Alterations of H19 and LIT1 Distinguish Patients with Beckwith-Wiedemann Syndrome with Cancer and Birth Defects The American Journal of Human Genetics, Volume 70, Issue 3, 1 March 2002, Pages 604-611 Michael R. DeBaun, Emily L. Niemitz, D. Elizabeth McNeil, Sheri A. Brandenburg, Maxwell P. Lee and Andrew P. Feinberg Abstract Beckwith-Wiedemann syndrome (BWS) is a congenital cancer-predisposition syndrome associated with embryonal cancers, macroglossia, macrosomia, ear pits or ear creases, and midline abdominal-wall defects. The most common constitutional abnormalities in BWS are epigenetic, involving abnormal methylation of either H19 or LIT1, which encode untranslated RNAs on 11p15. We hypothesized that different epigenetic alterations would be associated with specific phenotypes in BWS. To test this hypothesis, we performed a case-cohort study, using the BWS Registry. The cohort consisted of 92 patients with BWS and molecular analysis of both H19 and LIT1, and these patients showed the same frequency of clinical phenotypes as those patients in the Registry from whom biological samples were not available. The frequency of altered DNA methylation of H19 in patients with cancer was significantly higher, 56% (9/16), than the frequency in patients without cancer, 17% (13/76; P=.002), and cancer was not associated with LIT1 alterations. Furthermore, the frequency of altered DNA methylation of LIT1 in patients with midline abdominal-wall defects and macrosomia was significantly higher, 65% (41/63) and 60% (46/77), respectively, than in patients without such defects, 34% (10/29) and 18% (2/11), respectively (P=.012 and P=.02, respectively). Additionally, paternal uniparental disomy (UPD) of 11p15 was associated with hemihypertrophy (P=.003), cancer (P=.03), and hypoglycemia (P=.05). These results define an epigenotype-phenotype relationship in BWS, in which aberrant methylation of H19 and LIT1 and UPD are strongly associated with cancer risk and specific birth defects. Abstract | Full Text | PDF (126 kb) |
Copyright © 2000 The American Society of Human Genetics All rights reserved.
The American Journal of Human Genetics, Volume 66, Issue 5, 1473-1484, 1 May 2000
M. Alders1, 2, A. Ryan3, M. Hodges3, J. Bliek1, 2, A.P. Feinberg4, O. Privitera5, A. Westerveld1, P.F.R. Little3 and M. Mannens1, 2, ,
1 Department of Human Genetics, Academic Medical Center, Amsterdam
2 Department of Clinical Genetics, Academic Medical Center, Amsterdam
3 Department of Biochemistry, Imperial College of Science, Technology and Medicine, London
4 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore
5 Laboratorio di Citogenetica, Azienda Ospedaliera di Legnano, Legnano, Italy
The genetics of Beckwith-Wiedemann syndrome (BWS) is complex and is thought to involve multiple genes. It is known that three regions on chromosome 11p15 (BWSCR1, BWSCR2, and BWSCR3) may play a role in the development of BWS. BWSCR2 is defined by two BWS breakpoints. Here we describe the cloning and sequence analysis of 73 kb containing BWSCR2. Within this region, we detected a novel zinc-finger gene, ZNF215. We show that two of its five alternatively spliced transcripts are disrupted by both BWSCR2 breakpoints. Parts of the 3′ end of these splice forms are transcribed from the antisense strand of a second zinc-finger gene, ZNF214. We show that ZNF215 is imprinted in a tissue-specific manner.

subset: commoncrawl


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According to a report by Adrian Wojnarowski, the Sixers have signed undrafted Marquette guard Vander Blue to a partially quaranteed contract.
The 76ers have released Justin Holiday, Jrue Holiday's older brother, per Eric Pincus of Hoopsworld. A larger portion of Holiday's salary would have been guaranteed had he been on the roster after August 15th.
Every year, the Liberty Ballers staff submits their own personal big board, listing out where we think NBA prospects should go in the draft.
We've got a long road ahead of us. Prepare yourself with dates and beers.
In the third part of the Liberty Ballers "Toot It or Boot It" series, we take a look at the future of Thadeus Young.
Determining once and for all if the Sixers have upgraded or downgraded their SWAG level this offseason.
Talking about the Sixers offseason and what to expect from the Sixers this year.
Part One of a semi-comprehensive look at each NBA Free Agent and if/how they'd fit in with the Sixers.
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Third Party Liability / Special Event Liability Coverage
Designed to provide low cost general liability insurance coverage to third party users of university facilities (Special Event Liability).
TULIP (Tenants and Users Liability Insurance Policy) may be a solution for groups and organizations who desire to use UNCG facilities for special events and fund-raisers as well as third party performers coming in to perform at the university request. The program was started through the University Risk Management and Insurance Association (URMIA) of which we belong to. This gives the user group a liability insurance purchasing option, to meet user University liability insurance requirements for fundraiser events and just as important, gives them their own liability insurance protection, given the reality that there is no immunity for anyone from liability exposures these days. Go to https://tulip.ajgrms.com for more information on the TULIP program.
The user group/organization can go online, complete the liability insurance application, and purchase direct from the insurer when qualified. The insurer will then e-send a certificate of insurance to UNCG which is listed as an additional insured for the event or activity at hand.
We have enrolled UNCG as a facility member institution to the TULIP program. To be user-friendly, we have already advised the insurer of our specific institutional insurance requirements for user groups, thus the applicant organization need only complete the rest of the insurance application details for their respective premium quote and conduct their own purchasing decision.
To apply for TULIP coverage, contact Tammy at 256-1102 or email@example.com to obtain the institutions user code and application information.


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Merida is the premier source for stylish natural fiber rugs. For more than 31 years Merida Meridian rugs have been designed with equal passion for sustainable design and stylish aesthetics making Merida rugs and area rugs the designer's top choice for elegant natural rugs.
If you have been unable to find what you are looking for, we hope the links below can assist you.


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- Product Views (click to enlarge):
Soho Dining Chair - Set of 2
by Nuevo
FREE SHIPPING!- Anodized aluminum construction
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Contemporary Furniture is something that Nuevo knows very well. For years, Nuevo has produced high quality furniture from Bar Stools to Home Accents.
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Find a Couple's Registry & Wedding Website
By Style Solitaire With Matching Band Multiple Stones Colored Gemstones Modern Traditional Vintage By Shape Round/Oval Square/Rectangle
Scarlett Johansson, Ashley Tisdale and Kaley Cuoco are just a few of the newly-engaged celebs rocking major rings. Want to copy their style? We've got the goods.
Just like Halle Berry and Jackie O, Zoe Saldana joined the emerald ring club with a stunning vibrant green engagement ring.
Get the look: A vintage emerald Trumpet & Horn ring with side stones.


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Associated Press
Publication: theday.com
New York — New York's Metro-North Railroad has restored service after a computer system power problem forced it to temporarily stop trains on three of its five lines. Residual delays are expected.
A spokeswoman for the nation's second-busiest railroad says its Hudson, Harlem and New Haven line trains were brought to a halt Thursday night for safety purposes while electricians worked to hook up temporary power to the computer system.
Trains were taken to the nearest stations, where riders were allowed to exit. All trains had power and heat during the two-hour interruption.
The cause of the power problem hasn't been determined.
Metro-North serves 281,000 riders a day in New York and Connecticut. It has experienced a spate of problems in the last year, including a derailment in the Bronx that killed four passengers.
Ralph Lauren has revealed the Team USA Olympic opening ceremony outfits (check them out at www.ralphlauren.com), including a cardigan that is a patriotic patchwork of stars and stripes. What are your thoughts on the look?


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House of Image: 3 Artists & Guests, 1/11/02-2/8/02 3 Artists & Guests an exhibition of art & form
Otto Czerepak, Christopher Miller and Raymond Whalen
Otto Czerepak "The greatest challenge for me is to create a visual dialogue through the interaction of the medium, form, technique, ideas and aesthetic vision. My goal is to achieve a freedom in design innovation, and to transform an assembly of fractured, cut, snipped and hammered pieces of tile into an experiment in playful pleasure, love of art/form and visceral artistry." Guest: Katya Czerepak Greer
Form I Otto Czerepak painted plywood, mirrors and ceramic


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Izzy Rose
Izzy Rose |
Name:Izzy Rose Birthday:Feb-2011 Age:3 years, 1 month Sex:F Weight:61 pounds State:AR Contact:Paula Lackner 715-584-5961 Email:email@example.com |
31 Jan 2014 Update - ADOPTION PENDING
Meet Izzy Rose – she is a WONDERFUL 2 ½ year old girl who LOVES her people and gets along well with all of her big 4-legged foster sisters and brother – Izzy has an extremely high prey drive and will not be able to ever live with or be around dogs who are smaller than she is (nor will she be able to live with cats).
She is a smart girl who loves to play with her toys – particularly loves squeaky toys and tennis balls, and the occasional June bug that flies into her path. She is a playful, loyal girl, loves to ride in the car. She will need a home that will provide boundaries in a loving, firm way and that will continue to help her build her confidence in new situations (going to the pet store, socialization, etc.). She is crate trained, knows her basic obedience commands and is an all-around cuddly girl. She has been spayed and is up to date on her shots.


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Sir Frederick Grant Banting was a Canadian scientist and doctor, whose research led to the discovery of insulin to treat diabetic patients.
Thomas Bowdler was a physician and self-appointed editor of great literature. He published The Family Shakespeare, a family friendly version of Shakespearean works, in 1807, and gave rise to the term "Bowdlerized."
An expert in the field of mind-body healing, Deepak Chopra is a world-renowned speaker and author on the subject of alternative medicine.
Claudette Colvin was a civil rights activist in Alabama during the 1950s. She refused to give up her seat on a bus months before Rosa Parks' more famous protest.
M. Joycelyn Elders is a physician who briefly served as U.S. Surgeon General under President Clinton.
James Herriot was a British veterinarian and author best known for his books detailing life as a country vet. Two films and a TV series were based on his book All Creatures Great and Small.
African-American chemist Percy Julian was a pioneer in the chemical synthesis of medicinal drugs such as cortisone, steroids and birth control pills.
DaSusan La Flesche Picotte was the first Native American female to become a physician in the United States. A member of the Omaha Reservation, she worked there as a physician until 1894.
Rita Levi-Montalcini shared the 1986 Nobel Prize for physiology or medicine for her part in the discovery of a protein that stimulates nerve cell growth.
With his brother Louis, inventor Auguste Lumière pioneered the Cinematographe motion picture camera and made groundbreaking innovations in color photography.
Senator Rand Paul, son of Congressman Ron Paul of Texas, is best known for his support of the Tea Party movement and his controversial comments on the Civil Rights Act.
Army medic Clarence Eugene was awarded the Medal of Honor for treating wounded Vietnam soldiers amidst gunfire despite having been shot in both legs himself.
Controversial radio host Laura Schlessinger, also known as "Dr. Laura," is an expert at giving listeners—and readers—a piece of her mind when it comes to moral living and leading a successful family life.
Dr. Anna Howard Shaw was the first female minister in the Methodist Protestant Church. She spent most of her life working for the cause of women's suffrage.
Su Shi was an 11th century Chinese scholar, writer and visual artist renowned for the excellence of his craftsmanship.
J. Robin Warren is a Nobel Prize-winning pathologist who, with Barry J. Marshall, identified the bacteria that causes ulcers.


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Photo: Stuart Tyson/Studio D And There Was Light
By Jacques Lusseyran Background: This is a memoir written years after World War II by a man who, as a 16-year-old boy, started a Resistance group made up mainly of teenagers in Nazi-occupied Paris. That alone is incredible, but he was also blind. He was particularly valuable to the movement because he could almost always tell when people were lying. He couldn't see, but he felt "light" coming from people. I find it amazing that he turned his blindness into an enlightening experience. Why he chose it: A lot of people don't know about this memoir, and it gives such a unique perspective on one of the most dramatic periods of human history. Also, Lusseyran had a very clear moral compass; he risked his life for the benefit of other people. "I don't believe in God. I believe in G-O-W" Advertisement
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Welcome to New Frontier Treatment Center
New Frontier Treatment Center is a not-for-profit community based organization established and incorporated in 1971 to provide substance abuse treatment services to individuals and their families.
As substance abuse continues to be a health concern for the nation and an increasing problem in Nevada, New Frontier continues to address and meet the need for additional treatment services. It is our priority to incorporate best practices, and to offer research-based, effective drug, alcohol and gambling addiction treatment to Nevadans of all ages. New Frontier accepts donations and contributions, both financial and material.
News & Events
Recovery Month 5K - Join in and support Churchill County Recovery Month.
Recovery Month 5K - Join in and support Churchill County Recovery Month.


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I'm pretty sure Brown is the canidate that most people want but this is interesting Silas seems to REALLY want to be here too.The Charlotte Observer -
If Larry Brown isn't destined to become the head coach of the Bobcats then Paul Silas would love to bring his Carolina ties to the organization, according to the Charlotte Observer.
He is a former coach of the Charlotte Hornets and lives in the area.
"They need someone who knows how to handle people, get the most out of them," Silas told the Observer. "My teams have always been really good defensive teams. This team has that potential" in terms of personnel.
He calls coaching the Bobcats a "dream job."


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AlligatorDundee ●
- 5 stars Rating: 92
9998 votes total - Heisman
- (22447)
- 25 months
- 5 stars
shavisimo2 ●
- 5 stars Rating: 94
12736 votes total - (17761)
- 41 months
- 5 stars
Weedline said...
OL Chance Warmack- Has been said by many to be the top overall player int he draft regardless of position. Depending on who you listen to, he can go in the top 5 or top 20. Some think he has done enough to warrant such a high pick and have said he's the best guard prospect they have ever seen.
Weedline said...
I assume you mean which players are winning and losing? If so, here are a few from our team:
DB Robert Lester- Ran a bad 40, and had a very bad week in the all star game. He is looking like a 4th+ round pick right now.
OL Barrett Jones- Not sure he is losing that much. But I kinda felt he would talk himself into the 1st round. Now it's looking like the 2nd.
TE Michael Williams- I don't know the specifics, but he didn't get to workout at somewhere for some reason. I'm pretty sure it wasn't his choice either, it was like he wasn't invited. Don't hold me to those details, but it was something like that. He will get drafted, but I think most of us thought he would be thought of in much of a higher regard. He is a GREAT run blocker.
OL DJ Fluker- He's seen his stock rise like crazy. In fact, one guy said this week it's risen faster than anyones else. He looks like a sure thing for the 1st round right now.
DB Milliner- He might be a top 5 pick. Not sure what happened, but a lot of people have him very high. A few have him as high as number two in the entire draft.
RB Eddie Lacy- Seems like he is going to sneak into the first round. The Falcons released their RB and have really started looking at him hard. I think he is right there on the cusp of the 1st and 2nd round. Right now, most are saying 1st.
OL Chance Warmack- Has been said by many to be the top overall player int he draft regardless of position. Depending on who you listen to, he can go in the top 5 or top 20. Some think he has done enough to warrant such a high pick and have said he's the best guard prospect they have ever seen.
- 5 stars Rating: 83
1613 votes total - Back-up
- (4041)
- 35 months
- 5 stars
eastcoastghost said...
DB's havent run yet, so I dont know where Lester ran a bad 40. Lacy isnt working out due to a hamstring. Warmack actually didnt perform that well yesterday. Pretty slow 40, and didnt look all that athletic in drill work according to the analysts. If Milliner runs sub 4.5 he will be top 5, no lower than top 10.
ScarletnCream ●
- 5 stars Rating: 89
8419 votes total - The Neck
- Heisman
- (43510)
- 27 months
- 5 stars
downlowdawg ●
- 5 stars Rating: 96
7138 votes total - First Team All-American
- Starter
- (7796)
- 27 months
- 5 stars
Weedline said...
1. Lester ran it 5+ times in Mobile. Everytime it was horrible. They pretty much lied the last time he ran it and said it was "in the high 4.7's". I don't know, maybe so. But I doubt it. More like 4.8's. Everytime his name is brought up people mention that performance. Unless something drastic has changed, I can;t see a guy changing it that much in this short a time. Call my cynical. We'll see
2. OK, what's your point? Lacy has seen his draft stock rise from a 3rd rounder to a probable 1st round pick. That's a winner in my book. lol
3. I could link you 40 articles about how well Warmack is doing but all you have to do is google it. The very first article that comes up is from yesterday. It has quotes form NFL organizations singing his praises saying they should take him anywhere in the draft. You will see a lot of quotes like this: "Warmack is one of the top 2 or 3 guard prospects I've ever evaluated in all my year." Warmack is arguably the best guard prospect since Steve Hutchinson." Etc.....I mean, I know you rag on Bama all the time, but this one sent it over the edge. lol
4. I'm not trying to be an ass here, just curious, where do you get this stuff?
- 5 stars Rating: 83
1613 votes total - Back-up
- (4041)
- 35 months
- 5 stars
- 4 stars Rating: 67
3972 votes total - Redshirt
- (3840)
- 29 months
- 4 stars


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Hither and zither and yon and on. Except for the zither. Mostly.
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Online Edition: Winter 2008/2009
This is a printer-friendly version of this article. Click here to return to Rain Taxi.
The Year of Henry James
The Story of a Novel
David Lodge
Penguin Global ($18)
by Jerome Klinkowitz
It would be easy to dismiss David Lodges new book as the whinings of a prickly Englishman about how his novel, Author, Author (2004) failed to make the 22-title longlist for Britains prestigious Man Booker Prize. Hed been on the five-volume shortlist twice before, in 1984 with Small World and four years later with Nice Work, and had feasted on the benefits, including popular reissues of all his novels in the U.K. and U.S., graced with appealing covers by cartoonist Paul Cox and lavish introductions by the author himself. The Man Booker contest had lifted Lodges fiction from his publishers midlist to bestsellerdom, without any compromises of artistic merit. Author, Author, an especially inventive experiment in the relatively new field of historical metafiction, was meant to test the creative limits of the authors hard-won fame. And then, by a flabbergasting series of accidents and coincidences, Lodges race for the prize ran afoul.
So its natural to moan about how things went badly. David Lodge surely does make a fuss about it, albeit in a tempered measured way. Indeed, theres a great comedy in the mans mastery of suppressed rage, quelled in a way that invites the readers cynical sympathy—after all, as a critic Lodge is an expert on the work of Evelyn Waugh. But theres also plenty of room for serious thoughts about the nature of contemporary fiction, from how its marketed all the way back to how its conceived. The Year of Henry James: The Story of a Novel is a novella-length narrative that shares space with eight shorter essays on literary self-consciousness; the eponymously titled volume as a whole qualifies as one of David Lodges more important books, where even the whinings make serious points.
The story of the novel is simple: Author, Author was meant to stand as an imaginative investigation of Henry Jamess futile attempts to become a broadly popular author, and how his failures at this (including a disastrous foray into the theater) humbled him in the face of his close friend George du Mauriers dumb-luck success with Trilby, one of the best selling novels of all time. In working out the narrative, Lodge made as great or greater progress in writing a biographical novel as did E. L. Doctorow, Robert Coover, Don DeLillo, and so many others who in recent years have embraced the form. The form is metafictive not simply because of authorial self-consciousness but because of the readers awareness of whats real and whats made up. As a successor to the more blatantly innovative fiction of the 1960s and 1970s, historical metafiction has reinterpreted realism for our times, taking advantage of all the benefits of anti-illusionistic writing while hanging on to shared history as well. Lodges title essay goes a long way toward explaining just how this process works, and deserves study as a critical document.
No matter that its anecdotal. The anecdotes are alternately infuriating and hilarious—and, like Evelyn Waugh, the author relishes their telling. Given that storytelling is the subject here, why shouldnt Lodge tell some good ones? Their value is that theyre indicative of how an interesting new form of fiction is being made. And then unmade, in his case, by certain idiocies of the publishing world. But thats how one learns things: by taking them apart, at times uncovering the assumptions that had been disguised as truths. That it all fell apart (in terms of reception) suggests how it may all stay together the next time around.
Click here to buy this book from Amazon.com
Click here to buy this book from Powells.com
Winter 2008/2009 Table of Contents
Rain Taxi Online Edition, Winter 2008/2009 | © Rain Taxi, Inc. 2008/2009


text:
Posted 2 years ago
(34 items)
Marking(s): J.B. 1138
I think romantic is the perfect name for this beauty of a ring box with its roses, leaves, scrolls and swirls. Although its lining is long gone and its exterior and interior has been painted, this ring box is still over 90 years old and has earned its place in any collection. It measures approximately 2.5" x 1.75" x 2.25".


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The Oxford Half Marathon returns to the city on Sunday, October 13, 2013. Grab Monday's Oxford Mail for a free supplement of the results and times. And from 9am the day after the half marathon, we will have souvenir pictures of the runners crossing the finishing line for sale. Also, follow our coverage on the day right here or via our Twitter account @TheOxfordMail
Buy souvenir pictures from the Oxford Half Marathon finishing line
12:00pm Tuesday 15th October 2013
Oxford Half Marathon 2013: Results
8:00am Tuesday 15th October 2013
The results for the 2013 Oxford Half Marathon, supplied by the organisers, and based on chip time.
Live Live Blog from today's Oxford Half Marathon
8:22am Sunday 13th October 2013
Live coverage from today's Oxford Half Marathon. All the colour and all the info you'll need today.
Oxford Half Marathon field has grown threefold in its first two years
6:00pm Wednesday 9th October 2013
Half Marathon full signs go up ahead of event
3:00pm Friday 13th September 2013
THE Oxford Half Marathon has sold out for the first time in its three-year history.
Coaches lace up for charity
5:00pm Tuesday 20th August 2013
OXFORD United coaches Darryl Cribben and Kevin Warland like to stay match-fit.
Be sporty and help with the half-marathon's smooth running
7:00am Tuesday 30th July 2013
MORE than 350 volunteers are needed to help this year's Oxford Half Marathon run smoothly.
No half measures in run for hospice
5:00pm Friday 19th July 2013
DEALING with a child's terminal diagnosis is the hardest thing for any parent to have to do.
Strike up the band and help marathon go with a swing
6:00pm Friday 5th July 2013
Tim sets a time target for the Oxford Half Marathon
2:00pm Wednesday 12th June 2013
RUNNERS are limbering up for this year's Oxford Half Marathon.
City's half-marathon set to be a sell-out
1:02pm Monday 27th May 2013
DUST off those trainers and prepare for a summer of running.
Mothering Sundae: Spring shoe dilemma is such a bind
10:00am Monday 27th May 2013
I'm thinking of implementing traditional Chinese foot-binding techniques in the Sundae household.
No Coffey break for this pair of runners
6:00pm Wednesday 17th October 2012
IT was a real Coffey morning for two at Sunday's Oxford Half Marathon.
And they're off - Oxford Half Marathon runners set off from the Kassam Stadium
9:50am Sunday 14th October 2012
ABOUT 4,200 runners have this morning set off from Kassam Stadium on the Oxford Half Marathon.
Final chance to sign up for half marathon
1:00pm Thursday 4th October 2012
YOU'LL have to hurry to enter the Oxford Half Marathon – with just one day left to register.
Mini workers get set for a marathon effort
6:00pm Tuesday 11th September 2012
A TEAM of workers from Oxford's Mini plant are getting revved up to run the Oxford Half Marathon.
New route for Oxford half marathon
3:53pm Wednesday 4th April 2012
SIX thousand runners wanted for the 2012 Oxford Half Marathon in aid of Helen and Douglas House
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1nfected Scriptwright |
I get an alert box saying something like: "Something went wrong with the framework blah blah, would you like to go the script page?" I do have the US Framework installed and it's placed above this script in the order of execution. What could be the problem bro? |
jerone Script's Author |
All my scripts (that required US Framework) aren't working anymore because of an update from GreaseMonkey :)
Thnx for using. |
jerone Script's Author |
Ok, I just updated this script.
Have fun using it. |


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Linux Red Hat Certified Engineer Exam Cram
Author: Kara J. Pritchard
Publisher: Certification Insider Press/Coriolis
Price: $29.99 US
Reviewer: Andrew G. Feinberg
Every time I walk into a bookstore, I see rows upon rows of Linux books and Windows books, all alike. However, the one area where Linux is lacking is in certification. Like myself, you may not believe that certifications are a true measure of ability. Nonetheless, Linux does have one certification exam in the form of the Red Hat Certified Engineer program (RHCE). This exam even has a new book to go with it, Kara J. Pritchard's RHCE Exam Cram.
The author assumes the reader knows a bit about UNIX in general and does not go into detail regarding basic skills. Chapter 1 is an introduction to the RHCE-300 exam itself, and Chapter 2 is an introduction to the history of Linux and free/open source software. The book includes a self-assessment at the beginning to determine whether one needs it. If you want a tutorial, this is not for you. For UNIX users who may not be administrators, Ms. Pritchard gives a good introduction to basic administration concepts in Chapter 3. Chapter 4 goes into great detail about the basics of TCP/IP and related services. Chapter 5 covers the basics of a Red Hat Linux installation, with which some readers might not be entirely comfortable, and after a brief interlude of basic system administration, Chapter 6 immerses the reader in dual-boots, kickstarts and other wonderful features of the Red Hat Linux installer. Chapter 8 covers quotas, run levels and the nitty-gritty of custom kernel compiles, as well as teaching one how to deal with crontab and profile files.
Chapter 9 does a wonderful job of showing how to configure the X Window System from scratch, as well as clueing a user in on several popular window managers including the GNOME and KDE environments. Chapter 10 describes how to configure Apache, Sendmail, FTP, DNS, NFS and Samba, as well as DHCP, Time Configuration and Squid. I found this section to be the most informative and useful outside of the realm of Red Hat Linux. I consulted the Samba section of the chapter when I had to help a friend configure a home network with Samba, which I had never done before.
Chapter 11 shows how to take a newly networked system and secure it, something every Linux administrator should know, including the basics of NIS, working with PAM, tcp_wrappers, routing and firewalls with ipchains.
Chapters 12 and 13 explain the process of the installation exam and the debugging exam, with Chapter 14 being a practice test and Chapter 15 its answer key. I am happy to report that I scored a 47 out of 50 on my first try, thanks to Ms. Pritchard's wonderful tutorials and test hints.
This being an exam preparation book, Ms. Pritchard does a good job of placing sample questions pertinent to each section throughout the book at the end of each chapter. She also lists external resources, such as HOWTOs, FAQs and other books on the subject at the end of each chapter. Every chapter has numerous exam hints, tips and tricks that are useful when you take your test.
Linux certification might not be the best way to ensure quality and skill of administrators, but it is a step toward getting Linux accepted in the corporate marketplace. Certification programs may produce cookie-cutter administrators, yet they will have very marketable and consistent skills useful not only with Linux, but with UNIX in general. Ms. Pritchard's book does a great job of introducing someone to, and preparing them for, the Red Hat Certified Engineer exam, and hopefully, will lead Linux users to bigger and more interesting learning experiences.
Andrew G. Feinberg is a developer of Debian GNU/Linux. In his spare time, he can be found working on the High School Linux User Group project (hs-lug.tux.org) or attending classes at Walt Whitman High School in Bethesda, MD. He can be reached with questions, comments, or letters of college acceptance at firstname.lastname@example.com.
Linux has become a key foundation for supporting today's rapidly growing IT environments. Linux is being used to deploy business applications and databases, trading on its reputation as a low-cost operating environment. For many IT organizations, Linux is a mainstay for deploying Web servers and has evolved from handling basic file, print, and utility workloads to running mission-critical applications and databases, physically, virtually, and in the cloud. As Linux grows in importance in terms of value to the business, managing Linux environments to high standards of service quality — availability, security, and performance — becomes an essential requirement for business success.
Sponsored by Red Hat
If you already use virtualized infrastructure, you are well on your way to leveraging the power of the cloud. Virtualization offers the promise of limitless resources, but how do you manage that scalability when your DevOps team doesn't scale? In today's hypercompetitive markets, fast results can make a difference between leading the pack vs. obsolescence. Organizations need more benefits from cloud computing than just raw resources. They need agility, flexibility, convenience, ROI, and control.
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What virtualization solution do you use/manage at work? | Mar 04, 2014 |
Our Assignment | Mar 04, 2014 |
March 2014 Issue of Linux Journal: 20 Years of Linux Journal | Mar 03, 2014 |
Have Resume - Will Travel | Feb 28, 2014 |
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2 weeks 4 hours ago - Wonder when LJ is going to
2 weeks 16 hours ago - Puerto Rico Free Software
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2 weeks 2 days ago - I hate voice commands
2 weeks 3 days ago - usabilty --- AGAIN with this nonsense
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CHARLESTON, W.Va. -- Ray Turner at Huntington
HUNTINGTON -- The opening reception for Population by Walter Gropius Master Artist Ray Turner takes place at 7 p.m. Friday<co Oct. 18> at the Huntington Museum of Art, with a public presentation by Turner followed by a reception. Admission is free.
A three-day workshop facilitated by Ray Turner takes place from 9 a.m. to 4 p.m. Oct. 18, through Oct. 20. For workshop fee information or to register, call 304-529-2701.
Population is a series of portraits that celebrate a cross-section of people from across the country, including Huntington.
Portraits of several Huntingtonians are intermixed with selected paintings from the larger, ongoing series in a large-scale installation. Primarily oil paint on 12- x 12-inch glass, Turner's textural paintings are considered to be interpretive rather than purely representational. The exhibit runs through Nov. 10.
The Huntington Museum of Art, 2033 McCoy Road, Huntington, WV. The museum is open from 10 a.m. to 9 p.m. Tuesday, 10 a.m. to 5 p.m. Wednesday through Saturday and noon to 5 p.m. Sunday. The museum is closed to the public Monday. Membership begins at $25 and benefits include free admission. Contact 304-529-2701 or www.hmoa.org.
Governor's Mansion holiday ornament reception
At 4 p.m. Oct. 17, first lady Joanne Tomblin will host the Governor's Mansion holiday ornament introduction and reception with artist Shelley Goodman. Limited edition ornaments will be available for sale.
The event will take place at the Culture Center at the state Capitol Complex, 1900 Kanawha Blvd. E. For additional information, contact Caryn Gresham at 304-558-0220.
Free downloadable music at the library
Beginning Oct. 14, Kanawha County Public Library will be providing free, legal downloads of songs through Freegal Music Service with access to more than 7 million songs. Patrons will be able to choose from more than 28,000 music labels from 85 different countries.
"With just a library card and a PIN number patrons can now own three new songs every week at absolutely no cost to them," said Toni Blessing, adult services manager at the library.
Registered cardholders will be able to download songs in the MP3 format through the KCPL website at kanawhalibrary.org. Sample music clips are available to listen to before selecting a song to download. The Freegal Music Service has free mobile apps available in the Apple App Store and Google Play. For more information, contact Blessing at toni.bless...@kanawhalibrary.org or 304-343-4646 ext. 1284.
Watch Tamarack artists at work
BECKLEY -- Visitors to Tamarack may watch artisans Dewayne Gregory create wood carvings and Stephanie Danz make stained glass from 10 a.m. to 6 p.m. today.
From 10 a.m. to 6 p.m. Oct. 19 - Oct. 21, Suzanne Kniceley will demonstrate making textiles and Anne Beardslee will show how to make pine needle baskets.


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March 20 (Bloomberg) -- Bloomberg Government energy analyst Alison Williams, defense analyst Robert Levinson, and Rick Kamin, the Navy's fuels team lead at Patuxent Naval Air Base, examine the Department of Defense's plans and options for replacing petroleum-derived jet fuel with biofuel. Williams and Levinson outline their findings in a Bloomberg Government Study, "Defense Department Seeds Market for Petroleum Alternatives."(Source: Bloomberg)
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Chocolate Chip Toffee Bars >
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Chocolate Chip Toffee Bars
"This is so simple and satisfying for a chocolate lover like myself." No one will resist these crumbly, chocolate chip bars. —Kimberly Post, Colwich, Kansas
36 Servings
Prep: 20 min. Bake: 35 min. + cooling
2-1/2 cups all-purpose flour
2/3 cup packed brown sugar
3/4 cup cold butter
1 egg
1 cup chopped almonds
2 cups (12 ounces) semisweet chocolate chips,
1 can (14 ounces) sweetened condensed milk
1-3/4 cups toffee bits, divided
In a large bowl, combine flour and brown sugar; cut in butter until
mixture resembles coarse crumbs. Add egg; mix well. Stir in almonds
and 1-1/2 cups chocolate chips. Set aside 1-1/2 cups for topping.
Press remaining mixture into a greased 13-in. x 9-in. baking pan.
Bake at 350° for 10 minutes. Pour milk over crust; sprinkle with
1-1/2 cups toffee bits, reserved topping and remaining chocolate
chips. Bake 25-30 minutes longer or until lightly browned. Sprinkle
with remaining toffee bits. Cool on a wire rack. Cut into bars.
Yield: 3 dozen.
Nutritional Facts:
1 bar equals 246 calories, 13 g fat (6 g saturated fat), 24 mg cholesterol, 112 mg sodium, 30 g carbohydrate, 1 g fiber, 3 g protein.
© Taste of Home 2014


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Cold Fish Reviews
After several grisly murder cases in Japan in the '80s and '90s were blamed on screen violence, local government officials put pressure on domestic horror filmmakers, leaving the majority of them MORE
If you're familiar with the work of Japanese filmmaker Sian Sono, you already know what to expect from Cold Fish: something entirely unpredictable. The film will not disappoint.
A strange, savage, and MORE


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•TUESDAY, NOVEMBER 22nd 2 0 0 5 •
Being one of his top ten favourite months, John has decided to offer FREE SHIPPING on ALL regular priced shoes and boots for the rest of November (excludes clearance and sale styles). Simply type HOTSHIP into the coupon field upon checkout and your shipping is on John. This offer is based on regular UPS GROUND service and will not apply to any orders that require air transportation. Don't Delay Fluevog Today!
John Says: "If you only knew what a Fluevog could do."
Watch out California - Once again, the tireless John Fluevog is packing up his carry on (a JF 240 Wagon Laptop Bag ) and hitting the road for another stop on his 35 Years Anniversary Tour. San Fran Fluevog: Friday, December 2nd LA Fluevog: Saturday, December 3rd Please feel free to stop by - John would love to see you (especially you). Come and ask him if he'll ever do an edible Christmas shoe, or what it's like to be an authentic West Coaster. Find out which he likes better – shoes or cars, ask him to sign your new Fluevogs, ask him to sign your old Fluevogs, tell him about your strategy for World Peace or about how you're new to LA and would he recommend the area where he lived in LA a number of years back. Either way, if you're in the area, stop by and say hello.
Having trouble deciding which Fluevog is the perfect one for your honey? Fret no more! John Fluevog Gift Certificates are the best solution to your holiday worries. Order one of these up until midnight December 24th and we can still get it to your sweetie by Christmas Day. Available in denominations of $10 starting at $20 they can be used against purchases either online or in one of eight North American John Fluevog Stores... Don't Delay Fluevog Today!
We've added a wack load of Shoes to our Clearance section over the past week to make your fall a joyous shoe-filled one. It's all divided into size availability so you don't have to spend a long time trying to find something that fits you. Everything in this section is limited quantity while supplies last. Plus we have both a US and a new CANADA section.
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Breast Self-Exam (cont.) Medical Author:
Serdar H Ural, MD
Aneela Naureen Hussain, MD, MBBS
Medical Editor:
Jerry R. Balentine, DO, FACEP
Jerry R. Balentine, DO, FACEPDr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident. IN THIS ARTICLEMultimediaMedia type: Illustration Next Page: Must Read Articles Related to Breast Self-Exam
Breast Lumps and Pain
Breast changes are common. From the time a girl begins to develop breasts and begins menstruating and throughout life, women may experience various kinds of bre...learn more >>
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Common health tests may be performed in your doctor's office or even in the pharmacy. Regular health checks and screening for certain diseases and conditions ha...learn more >>
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Breast cancer is one of the most important diseases for women in the United States and constitutes one fourth of all cancers in females, making it the most common cancer in females.


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This second volume of the brilliant, bestselling Bartimaeus sequence. Two years have passed since the events of The Amulet of Samarkand and the young ... Show synopsis
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Location of these events unknown.
Full titles reads: "EVERY LITTLE HELPS - Every Helper has done his or her part - have you done your share for the Mater Carnival ?"
M/S of two women in fancy dress for the charity event. they both chat to a gentleman and hand him some kind of badge....
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Lakota West seniors Ali Barnes and Monty Boykins have recently received offers to play college basketball. Lakota West head coach Sean Van Winkle announced this week that Barnes received an offer from Fairmont State and Boykins had added an offer from Eastern Kentucky.
Fairmont State, a Division II program in Fairmont, W. Va., is the first school to offer Barnes.
- Cincinnati Enquirer's recruiting blog with Mike Dyer
- Ali Barnes video highlights
- Monty Boykins video highlights
However, just last week, Mike Dyer of The Cincinnati Enquirer reported Eastern Kentucky was showing interest in the senior guard.
Last season, Barnes averaged 14 points, 1.6 rebounds, 1.9 steals and 2.1 assists as a junior last winter. He also made 52.8 percent of his field goals, 46.4 percent of his three-point shots and 62.3 of his foul shots.
Meanwhile, Boykins added Eastern Kentucky to his list of Division I schools that have offered him a scholarship. That list includes Duquesne, Eastern Michigan, Toledo, Kennesaw State, James Madison, Bowling Green, Kent State and Robert Morris. Previously, Boykins had an offer from Miami before the school hired a new head coach in April.
Boykins was a Division I honorable mention all-state this past season. He averaged 16.6 points, 6.2 rebounds, 2.1 assists and 1.4 steals. He was first-team all-GMC. As a sophomore, during the 2010-2011 season, Boykins averaged 12.5 points and 3.9 rebounds.
Another Lakota West basketball player that has the attention of college basketball scouts is junior point guard Tyler Williams, who already has offers from Miami and Kennesaw State.
Williams finished his second season on varsity and first as a full-time starter by averaging 10.8 points and 2.2 assists per game. He made 43.2 percent of his field-goal attempts, 36.9 percent of his three-point shots and 80 percent of his free throws. He was selected to the all-GMC second team.
Posted in: Sports, Winter Sports |


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A recent survey by UK-based online casino, RoxyPalace, found that 11% of single men would prefer to have a new iPad rather than a new lover. In fact, 3% would even be willing to leave their current partner for the latest iOS tablet. Meanwhile, 84% of women said they would stick to their companion, and "only a small percentage" would be willing to trade them for a new iPad. 4% of respondents would make the trade for something other than an Apple tablet - sorry Android, iOS beats you on the seduction front. The survey also examined iPad usage when it comes to romance. 44% had used an app to solve relationship problems, 15% consulted the internet for advice, and 71% would prefer to call someone over FaceTime before going on a first date.
While I wouldn't exactly call a casino a steadfast source of empirical research, the results are still pretty interesting. It's a classic "what would you do for a Klondike bar?" situation, except this Klondike bar costs over $500, and satisfies a lot more than your sweet tooth. Then again, so does a loving (human) partner. While not many of us would be willing to admit to being that one in ten that would pick an iPad over a girlfriend, do you personally know someone who would make the trade?
Source: Macworld
They'll get bored with an iPad too and throw it out. Sad day for the human race when a touchscreen is preferred over human interaction.
"...do you personally know someone who would make the trade?"
Yes. He's the editor of a blog that IsMORE than the iphone blog. :-) I kid, I kid.
God I love distorted Statistics!
11% of single men would prefer to have a new iPad rather than a new lover.... Meanwhile, 84% of women said they would stick to their companion.
Lets see:
100-11= 89% of men would choose a new companion
100-84= 16% of women would choose an iPad
Yes MORE Women would choose the iPad over a new lover then Men, but the whole article is slanted to make Men sound like the "bad guys" by the way the numbers are stated.
"Meanwhile, 84% of women said they would stick to their companion, and "only a small percentage" would be willing to trade them for a new iPad"
Reading comprehension is a quite a humdinger, isn't it? ;)
Some may consider 15% or less a small number. If the article is geared toward making men look bad.
In fact, 3% would even be willing to leave their current partner for the latest iOS tablet. Meanwhile... women... "only a small percentage" would be willing to trade them for a new iPad.
Reading comprehension is a humdinger, tricky to make sure you pair the right numbers even through the writers bad wording!
P.S. And 3% is a "small percentage!
The iPad would never threaten to stab you and in fact, cannot speak. If by some circumstance the iPads does speak, you are encouraged to disregard its advice.
In other news, research also indicates that 11% of single men and 16% of women in relationships are have lives that make me sad and might want to consider re-evaluating the process by which they select partners :-)
Strange, we are making comments on this. My sweet thing is on her iPod touch seeing what our kids have been up to. I am on the iPad reading this article. I think we will turn off both devices, and creat new stats. No telling what could happen.
An iPad is nice and all, but you can't make love to it (or at least, it's not sane to attempt to do so). I'd take a good lover over any piece of tech. Someone who chooses tech over a good lover, probably needs to get out more.
I'm that 1 in 10 but I have been abstinent for the past 5 years and 5 months so I guess I don't count.
I wonder if they would do this study for Asians willing to trade in organs or IOS devices... I dont mean that as a joke of course, just a sad fact of lack of value attributed to life...
I'm not even sure why this is an article. 11% isn't anything statistically interesting. I'm sure the same number would take a free HDTV, tickets to their favorite band, or a wide assortment of things over a new lover. I wouldn't be surprised if 1 In10 single men prefer masturbation to finding a new lover.
Damn that's missed up
It also goes with that study\servey I reed about the other day : on how BMW owners are twice more to be adulterers than other brands owners !!!!