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Love this awesome image as well! again, I love the great colors,details, and comp!
Awesome compo Michael. Love the colours and textures in this one.
very nice Michael!
Nice focus and dof
hi micheal ,i m back ...............this classic and lovely view and nice compo...........rock looking very clean and fresh ..............................good clicks
a great POV and edit Michael
nice comp michael
love the colors
nice focus and a excellent capture
Beautiful PoV, light (and shadow :-))
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PIC Programming with Linux
The vast majority of the computers in the world do not run Windows. While this is good news for Linux enthusiasts, the bad news is that they don't run Linux or much of any kind of operating system at all. These are the computers running your televisions, VCRs, cell phones, pagers and marine radios. They go by cryptic names like MC68HC05, 87C51, or PIC16C84 and are manufactured by companies like Motorola, Philips and Microchip.
Microcontrollers are the workhorse computers of the world. They do the repetitive tasks that require little or no human intervention and most of them will not even blink when the "millennium" bug hits their larger, faster cousins. They power up, do their job and power down again using very little power and defiantly not requiring a heat sink and a fan.
One of these little wonders is the PIC16C84 from Microchip. This is an 18-pin processor with 1KB of electrically erasable/programmable read-only memory (EEPROM), 36 bytes of SRAM and 13 input/output lines; it can operate at speeds ranging from DC (0Hz) to 10MHz.
The PIC16C84 is an excellent introduction to embedded processors and assembly language. The RISC instruction set has only 35 commands (op-codes) to learn, and the cost is under $8 for one. You can build a PIC programmer for under $20 in parts, or you can buy one pre-built and pre-tested over the Internet. Prototype boards are also available that need only a processor; they already have the clock crystal and programmer header, as well as a small prototyping area for adding to the circuits (usually a couple of LEDs for your first project).
This low cost for development doesn't mean that the PIC cannot be used for serious work. Several of my projects include an interface between the PC and the Dallas Semiconductor 1-wire bus, and a wired remote control that uses the Sony Control-L protocol to control a camcorder. In the most recent Circuit Cellar Ink contest, one of the winners implemented the PPP and TFTP protocol using an 8-pin PIC12C672.
Because of the ease of designing and building a PIC programmer to attach to a parallel port, dozens of designs are available, all using different pins on the parallel port. Some use inverters on all the control lines, and others use inverters on only some of the lines. My program picprg can handle all of these, as long as they use the standard five control lines. With all of these variations, the software to drive the programmer needs to be easily configurable.
Another feature of these devices is the ability to design a programming header into the circuit so that the processor can be programmed without removing it from the device it is attached to. This facilitates software work in the field, allowing technicians to easily service and upgrade the software.
When I first started using the PIC16C84, a compiler was already available for Linux, but no Linux software ran the HOPCO programmer that I use. An easy way to solve this problem would have been to get the DOS software included with the programmer to run under DOSEMU. Since I never seem to pick the easy way, I decided to write a native Linux PIC programmer. I decided on a full-screen ncurses interface, which would run on a VT console or an xterm as long as the TERM environment variable is set to xterm-color.
My picprg program allows you to program the PIC microcontroller, read previously programmed PICs, verify a PIC against the program in memory, and view the program in hexadecimal. It also features a versatile configuration screen, which makes it a snap to use with the wide variety of PIC programmers available.
Compiling picprg is easy: you just type make in the source directory and a binary called picprg is generated. The only dependency for picprg that may cause problems is the ncurses library. You must have v1.9.9e or later installed for it to work. All of the Linux distributions that I know of include ncurses by default, so you should be set. If you want to install it as suid root in /usr/local/bin, then type make install; otherwise, you will have to move it to your preferred final location.
picprg must be run as root, since it requires low-level access to the /dev/lp device that isn't available to normal users, even with write access enabled. You can either run it as root or install it as suid root, so that it can run as the root user. Remember that any program running suid root is a potential security risk.
The first time picprg is started, you must pass it the number of the printer port (/dev/lpX) to which you have attached the programmer. I have my modified HOPCO programmer attached to /dev/lp2, so I run picprg -p2 to start it for the first time. You will see a nice blue screen (I'm still addicted to the color scheme of my Atari 800) as shown in Figure 1.
The main menu is self-explanatory. Pick option C to get the configuration menu. Use the arrow keys to navigate the list of configuration options, and a short help message will be displayed for each selection.
Using a Pickit2
Here is a guide but is in spanish for programming a pic in C:
New Version - v2.3.0 Available Now
I have just relesed v2.3.0, which works with the v2.2.x and v2.4.x kernels. You can download it from the picprg homepage
Also, my homepage has changed to http://www.brianlane.com
Brian Lane
Re: New Version - v2.3.0 Available Now
Many thanks for developing this IMMENSELY useful programming tool! With any luck, my university will be using this in the years to come.
Re: New Version - v2.3.0 Available Now
Thanks! If you guys come up with any improvements please feel free to pass them on to me. I plan to revise the program sometime this year to add support for more of the PIC processors.
Prorammers like the PIC16PRO40, which allows programming different sized chips depending on their placement in sockets, has an extra control line labelled VPP40 (prog enable for 40 pin chips versus the other sizes).
Is it possible picprg could be extened to support the extra (optional) control line? If you like I could work it out, but I haven't looked at the code yet so don't know what I'd be biting off... and experience tells me its usually better to ask the source (no pun).
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see all genres ›Robust from the earliest days, German's film industry was one of the world's major exporters during the silent era. That largely shut down (and much of the top talent fled) as the Nazis came to power and postwar German cinema fell into a trap of stale, repetitive escapism. But the "New German Cinema" movement that arrived with the 1960s brought game-changing names (like Rainer Werner Fassbinder, Wim Wenders and Werner Herzog) with a resurgent energy that still hasn't fully abated.
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Gustav Froelich, best known as the young protagonist of METROPOLIS, stars as Holk, a strait-laced traffic cop who has the simple task of escorting a diamond thief to the police station. However, the thief is the exotic and beautiful Else (played by Betty Amann), which makes the task far from...Subscribe to watch now -
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Our 2009 vintage yields fresh melon and peach aromas and flavors enhanced by herb and orange peel components, a rich mouth-feel and great acidity. This fruit driven wine was made in the vineyard with grapes picked as they moved from slightly under-ripe to ripe; much like picking a peach as ... more
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Brownie Hearts
Get More
Subscribe to Martha Stewart LivingIngredients
- 1/2 pound (2 sticks) unsalted butter, plus more for cake pan
- 2 1/2 cups packed light-brown sugar
- 6 ounces unsweetened chocolate, coarsely chopped
- 4 large eggs
- 2 teaspoons pure vanilla extract
- 2 cups all-purpose flour
- 1/2 teaspoon salt
- Confectioners' sugar, granulated sugar, cocoa powder, for coating bites
Step 1
Preheat oven to 325 degrees. Butter a 9-by-13-inch cake pan. Cut a piece of waxed paper to fit the bottom, and press it onto buttered surface. In a large microwave-safe bowl, combine butter, brown sugar, and chocolate. Microwave on high for 1 minute; stir. If the chocolate is not softened, continue to microwave at 10-second intervals, removing before completely melted.
Step 2
Beat the eggs and vanilla into the melted chocolate with a wooden spoon. Beat in the flour and salt. Pour into prepared pan, and smooth the top. Bake until a toothpick inserted in the center comes out almost clean, 35 to 40 minutes. Let cool.
Step 3
Run a knife around the edge of the pan. Turn the brownie cake out onto a baking sheet, and flip over onto a work surface. Cut out the brownies with a 2 1/2-inch heart-shaped cookie cutter. Dust with cocoa if you like. Form the scraps into 1-inch balls, and roll them in the coating of your choice.
Everyday Food, January/February 2003Reviews (15)
Sheryll7 Feb, 2011
Thank you for the tip pinkcoco. I am going to use one less egg and add some corn oil to make them gooey and heavier. I don't think I can wait another week. probably making them tomorrow. Be still my heart, pixbymarlys, that sounds like heaven right here on earth.
KumaHeart15 Jan, 2011
wonder if i can make this sugar free and will it taste good.. i can change the brown sugar to truvia or will it taste like not eatable
tma27 Feb, 2009
Made a couple batches for a wedding reception and cut into little 1" hearts and this recipe is divine for that. I rolled some of the leftovers into 1" balls and froze some of the scraps for later. The texture is very good for cutting.
justLaurel15 Feb, 2009
babynia - you probably cooked them at least ten minutes too long. When I put a brownie recipe in tins I always start checking at about 15 to 20 minutes. Hope that is helpful.
ferlie - you are so right! How could I forget? Oh yeah, and the sliced strawberries?
babynia14 Feb, 2009
Tested the recipe and it turned out rather dry. Lots of crumbs when cutting through. I baked them directly in heart shaped moulds therefore I did get the perfect result without resorting to use of a cutter. Welcome any tips.
pixbymarlys13 Feb, 2009
I made my own hearts last year. This year I used a tin with 6 hearts and after spooing batter in each heart I pressed in carmel corn to outline the heart and sprinkled some peanuts and chocolate chips in the center. They look very ornate after being baked. I also made a large heart by using one recipe in a heart pan and imbellished with the carmel corn etc to give my grandsons. It's tucked in a large rectangle silver cookie tin lined with red heart paper.
ferlie13 Feb, 2009
justLaurel, you forgot the whipped cream!!!
justLaurel13 Feb, 2009
I think you should cut these in half, add marshmallow cream or raspberry jam then dip them in ganache. That would be a dessert worth having!
sofiab29 Feb, 2008
My family and I agree that these are the best brownies that we've ever made.
Taste great and easy to make! -
pinkcoco16 Feb, 2008
Very delicious but if you're looking for a fudgy brownie this is not the recipe for you.
sissygirlcooks13 Feb, 2008
the reason that you butter the pan before the wax paper or parchment is so it sticks to the pan well and enables you to press it into the corners well
RosinaRamirez13 Feb, 2008
Buttering the pan prevents the wax paper from burning and sticking to the pan. This is the way my mom baked before teflon and non-stick sprays existed. Try i it will work.
Sugarplums13 Feb, 2008
Why must one butter the pan, then press wax paper on top of the butter? Isn't this redundant? Couldn't one just place the wax paper into the pan? Please advise. Thank you.
gissie13 Feb, 2008
mjammjam ! my fam love it ,
thanks Martha for the brownies recepie ,Greethings Gissie
maricor12 Feb, 2008
i do really love brownies....i made it for my niece they all love it....thanks martha....


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TOKYO, April 23 (Reuters) - U.S. Treasuries prices stayed firm in Asia on Tuesday after small gains the previous day, with the 10-year yield stuck near four-month lows, on signs of an economic slowdown and low inflation in the United States.
* The benchmark 10-year notes traded at a yield of 1.696 percent, little changed from late U.S. levels and near four-month lows of 1.673 percent hit last Wednesday. It fell about one basis point on Monday.
* Although Treasuries yields briefly rose on Monday as the re-election of Italian President Giorgio Napolitano raised hopes for the formation of a new government in Italy, reducing safe-haven bids for bonds, concerns about the softening U.S. economic picture overwhelmed the market in the end.
* A string of weak data, including payrolls earlier this month, and a recent fall in commodity prices have fanned expectations that U.S. inflation could slow further, killing chances of the Federal Reserve tapering its bond buying program anytime soon.
* Last week, the government reported that U.S. consumer prices fell in March for the first time in four months. In the 12 months through March, consumer prices rose just 1.5 percent, sparking talk that the U.S. economy could face the threat of deflation.
* Some investors who had been cautious on Treasuries on the view that the Fed could start winding up its bond buying some time this year are rushing to buy Treasuries, according to traders.
* 'I expect the market's firm trend will continue until the next payrolls data. But the previous payrolls data could have been affected by bad weather, so if the next reading improves then the market may regard the weakness in March as a temporary one,' said Hiroki Shimazu, senior market economist at SMBC Nikko Securities.
(Reporting by Hideyuki Sano; Editing by Shri Navaratnam) Keywords: MARKETS TREASURIES ASIA/
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I am about to buy an ASA, and was wondering if anyone had experience installing one. If so, what are common mistakes I can avoid?
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Saturday\, May 4\, 2013 10 am – 12 pm Thom pson Creek Open Space Meet at Thompson Creek\, south of Carbondal e Join staff from Roaring Fork Conservancy as we take a family-friendly hike to the confluence of Thompson Creek and the Crystal River. We'll search to for signs of animals large and small and learn why animals like to live near the river. Bring a picnic lunch and enjoy sprin g-time along the river. Appropriate for kids of all ages and their parents . Please dress appropriately\; the hike will happen rain or shine. This fr ee event is underwritten by Pitkin County Open Space & Trails. Registratio n is required at www.roaringfork.org/events. Please call (970) 927-1290 wi th questions. Roaring Fork Conservancy is t he watershed conservation organization in the Roaring Fork Valley that bri ngs people together to protect our rivers. Celebrating over sixteen years of watershed conservation\, Roaring Fork Conservancy focuses on keeping wa ter in our rivers\, keeping our rivers healthy\, and keeping our riparian habitat intact. For more information call 927-1290 or visit www.roaringfor k.org.
DTSTART;VALUE=DATE:20130503 DTEND;VALUE=DATE:20130504 SUMMARY:Roaring Fork Conservancy's Thompson Creek Family Exploration URL:http://www.kmts.com/ai1ec_event/roaring-fork-conservancys-thompson-cree k-family-exploration?instance_id= END:VEVENT END:VCALENDAR


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Conundrum Wine Decanter
Product Details
Brand: |
The Conundrum Wine Decanter boasts a unique design that helps to improve the flavour and aroma of your wine for a more indulgent experience. As the wine is poured into the decanter, it travels out and onto the sides, which provides optimum aeration and oxygenation.
Also, when the wine is served, it flows over the specially-designed curves, which create a second phase of aeration to maximise the taste and scent. Finished with a brushed stainless steel base and a large spout for easy filling and pouring, the decanter has a capacity of 375ml, which equates to around half a bottle of wine. - L.M.
- Conundrum Wine Decanter
- Improves the flavour and aroma of wine
- Specially designed to optimise aeration and oxygenation
- Brushed stainless steel base
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Formation and Education for the Life of the Church
Title: Institute for Priests and Presbyterates Presenter
Joe Cook is the director of programming for the Institute for Priests and Presbyterates. Prior to his duties in the IPP, Joe served as Saint Meinrad's alumni director for eight years and as the Catholic campus minister for the University of Evansville for seven years.
Joe earned a Bachelor of Arts in communications and theater arts from St. Joseph College, Rensselaer, IN, and a Master of Arts in Catholic Thought and Life from Saint Meinrad Seminary and School of Theology.
He and his wife Lisa are the coordinating couple for Catholic Engaged Encounter in the Diocese of Evansville. He is the past president of the Serra Club of Evansville and a member of the Knights of Columbus Council 1584, Jasper, IN.
Topic of Presentation: Ethics and Accountability for Catholic parishes
Program: World Priest Program
"Stoking the Fire"
Mini-Sabbatical for Priests.
July 7 - August 2, 2014.
© Saint Meinrad Seminary & School of Theology 2014


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Last updated on 03/15/14 UTC
Necedah Overview
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The median age of homes in Necedah, WI is 26 years, with 43% of those homes owned, 16% rented and 39% not occupied. In the previous year, 0 Necedah properties were sold. The median sale price of a home in Necedah in the previous year was $89,500. Find a Coldwell Banker real estate agent in Necedah, Wisconsin today.
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Subspecialty Careers: Cardiology
.The Discipline
From the Greek kardia, meaning heart, as used in the Hippocratic treatises.
Cardiology is the prevention, diagnosis, and management of disorders of the cardiovascular system, including ischemic heart disease, cardiac dysrhythmias, cardiomyopathies, valvular heart disease, pericarditis and myocarditis, endocarditis, congenital heart disease in adults, hypertension, and disorders of the veins, arteries, and pulmonary circulation. Management of risk factors for disease and early diagnosis and intervention for established disease are important elements of cardiology.
Important procedural skills in cardiology include: cardioversion; arterial catheter insertion; balloon-tipped pulmonary artery catheter insertion; temporary and permanent pacemaker insertion; implantable cardiac defibrillator insertion; ambulatory electrocardiographic monitoring; echocardiography; left ventricular catheterization, coronary angiography and percutaneous vascular interventions; nuclear scan wall motion studies; stress electrocardiography; thallium perfusion scanning; and tilt-table physiology studies.
Cardiovascular fellowship training requires three years of accredited training beyond general internal medicine residency. Of the three years, a minimum of 24 months must include clinical training in the diagnosis and management of a broad spectrum of cardiovascular disease.
Training Positions
As of 2005, there were 173 ACGME-accredited training programs in Cardiovascular Disease and 2,142 active trainees. Eighteen percent of the trainees were female and 65% were US medical graduates.
The American Board of Internal Medicine offers certification in cardiovascular disease.
Approximately 82% of the graduates enter clinical practice in cardiology in the United States, and 16% enter academic medicine.
Major Professional Societies
The American College of Cardiology
American Heart Association
Major Publications
American Journal of Cardiology
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Journal of the American College of Cardiology
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Y LLE - bob nos Iau am 10.00 ar S4C!
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Enw (angen)
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Saturday Farmers' Market
For a weekly listing of vendors, visit the Farm Bureau web site
Why you should go:
- This is Honolulu's premiere farmers' market, the only one featuring all Hawaii grown and produced foods.
- This is a true farmers' market: the farmers and food producers are in attendance to tell you about their products, how they grow them and how you should prepare them.
- You'll find a variety of products including fruits, vegetables, flowers, beef, aqua cultured seafood, fresh baked breads, hand made pastas, tropical jams and jellies, unique snack foods, honey, baked goods, specialty seasonings and more. Shop for dinner at one stop.
- Come to eat breakfast: a different restaurant prepares hot breakfast plates each week. You'll also find fresh baked scones, oatcakes and other baked items to have with a cup of Hawaii-grown coffee.
What else you should know:
The Saturday Farmers' Market features top quality food items that are not readily available in other retail markets. Many of our vendors only supply restaurants. For example, you'll find:
- Nalo Greens from Nalo Farms, Waimanalo
- Sweet corn from Nozawa Farm, Kahuku
- Kauai shrimp by Ceatech, Kauai
- Farm raised moi by Cates International, Oahu
- Organic grass fed beef from North Shore Cattle Company, Haleiwa
- Vanilla beans and extract from Hawaiian Vanilla Co.
- Flavored mochi crunch by Pound da Mochi, Honolulu
- Organic eggs by Blue Lotus Farms
- Aged honey from Manoa Honey Company, Honolulu
- Heirloom tomatoes from North Shore Farms, Waialua
Tips for shoppers:
- Bring a shopping basket or bag; have a cooler with you, too.
- There's plenty of parking.
- There's lots of shade for pleasant shopping.
- It's THE happening place on Saturday mornings!


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Understanding Happiness with the Dalai Lama, a British Rabbi, an Episcopal Bishop, a Muslim Scholar: A Twitterscript
by Shubha Bala, associate producer
On October 17 of this year, Krista led a lively conversation with four dynamic religious leaders: the His Holiness the XIV Dalai Lama, Chief Rabbi Lord Jonathan Sacks, Rev. Dr. Katharine Jefferts Schori, and Seyyed Hossein Nasr on "Understanding and Promoting Happiness in Today's Society."
Trent and I sat in the media section of the Woodruff Physical Education Center at Emory University and our live-tweeted some of the special gems from discussion. You can also listen to the event's full audio.
- We'll be live-tweeting Krista's panel w/ @, @RabbiSacks, Rev. Schori, + Seyyed Hossein Nasr. Intros are beginning; discussion to start soon.
- Krista and religious leaders have taken the stage, followed by the @DalaiLama. All are standing in silence with one pair of hands clapping.
- The topic of this session: understanding and promoting happiness in today's society. Smiles everyone!
- "The reason different religious traditions developed is not for misery but for deep satisfaction (happiness). That's very clear."-@DalaiLama
- The @DalaiLama finally put on his classic deep red visor. He said to Krista - "Now I can see you clearer. There is a bright light in here."
- "If we could learn 1 thing from you - how to laugh the way you do - it would increase the happiness in the world." @rabbisacks to @dalailama
- "Simha tells us that happiness is part of the tenure and texture of relationships." @rabbisacks on Jewish definition of a shared happiness
- "Consumerism making us feel bad for what we lack is the most efficient system for the manufacturing+distribution of unhappiness" @rabbisacks
- "The paradox of the world is that to listen to a lecture on #happiness people have to stand in line unhappily for 2 hours to get in." -Nasr
- "#Happiness comes from this right relationship - from knowing you are not God and therefore not putting yourself in the center." -Rev Schori
- Some people have the idea that just following the truth is enough. #Islambelieves what's important is to attain #happiness."-Seyyed H. Nasr
- "The environmental crisis is due to this substitution - believing #happiness is to have, want more and more." - Seyyed Hossein Nasr
- "Once it was asked to a great #Sufi master 'What do you want?' He said 'I want not to want?' That's the epitome of #happiness." -Seyyed Nasr
- "Happiness is a permanent state of the soul, and we are here to attain it." -Seyyed H. Nasr to the @DalaiLama
- "That's why all the pain can lead to #happiness when you say to the bad times: I will not let you go until you bless me." - @rabbisacks
- "Happiness is not finding joy in death. It's taking what is, and insisting that great happiness for all is possible." - Rev. Schori
- RT @EmoryUniversity "Say to the bad times, I will not let you go until you bless me."—-Chief Rabbi Lord Jonathan Sacks
- "In Arabic, beauty and virtue — and the word goodness — are all the same word." -Seyyed H. Nasr
- "The #Arabic word for beauty, virtue, and goodness is the same. Beauty drives us to the divine…Beauty makes the soul happy." - Seyyed Nasr
- "Just by existing, we're responsible towards other creatures, humans, nature, and God himself." -Seyyed Hossein Nasr
- "Buddhism is in some ways atheist, but some say atheism means anti-God. In that sense, #Buddhism has respect for all traditions." @DalaiLama
- "Sometimes we don't have to pursue happiness, we have to pause and let it catch up to us." - @rabbisacks
- "There is a religious challenge in things that don't look beautiful." -@RabbiSacks
- "Happiness is a right. The purpose of our life is happiness. It may be simple but it's what I think!" @DalaiLama
- "When a person lives with hopelessness, they commit suicide. So our life depends on hope for happiness." @DalaiLama
- A nice segue by Krista from @RabbiSacks' fabulous point about slowing down for happiness to the @DalaiLama's teachings on meditation.
- "I almost drowned on my honeymoon, so when I wake up, I know what it means to pray: Thank you #God for giving me back my life." @RabbiSacks
- "We can face the future of fear if we know we do not face it alone." @RabbiSackson praying to #God and knowing God is with you
- Just realized there's a person signing this wonderful discussion at Emory. Her just to hear + translate must be incredibly difficult. Kudos.
- "Our modern culture makes it very hard to fail." -@RabbiSacks at The Interfaith Summit on Happiness
- "Train the body so the mind, the self, and the soul can do it's job more effectively." - Rev. Schori on #running as body meditation
- " #Judaism has a whole approach on the physical dimension of the spiritual life - it's called food." @RabbiSacks on #happiness and the body
- "If you want a summary of all the #Jewish holidays it can be done in 3 sentences: they tried to kill us, we survived, let's eat" @RabbiSacks
- "Someone elses' material needs, are my spiritual duty" @RabbiSacks on the responsibility to help others who are lacking
- @DalaiLama is asked: Where does body fit into happiness? HHDL: Without a body, there's no longer a brain. Then it's difficult to think.
- "You have to let go of hate if you want to be free" - @RabbiSacks
- "A #Muslim friend said 'jihad' is combating the negative forces within yourself. So then, the whole Buddhist philosophy is Jihad" @DalaiLama
- "After Buddhism there is no religion that speaks more of compassion than #Islamdoes." - Seyyed Hossein Nasr
- "I'm out of my medium. I'm used to being in a recording studio where people aren't applauding after comments" - Krista Tippett
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Registration will be available at the onsite registration desk at the Civic Auditorium in Santa Monica from Friday 13th October from 13:00-18:30 and according to the published registration desk opening hours.
We look forward to seeing you at the Meeting!
Extended Deadline for Submission of Abstracts
May 28, 2006
Notification of Accepted Abstracts
July 5, 2006
Deadline for payment of Late Registration Fee
September 15, 2006
Pre-registration for the Meet the Professor Sessions is mandatory. Please refer to the Meet the Professor Sessions section of the website for full details. Please specify your requested session/s when registering. Meet the Professor Sessions are inclusive in the IGCS Meeting registration fees.
Sunday, October 15th 2006, 6:00 pm Beverly Hilton, Beverly Hills, California For more details click here.
An evening with Trisha Yearwood to benefit the Global Alliance for Women with Cancer. In support of the prevention, detection and cure of cancer in women throughout the world.
Sponsored by IGCS Event Co-Chairs: Jill Grey & Susan Harris Cost for IGCS meeting participants and members: USD 250
Tickets will be sold on an individual basis. Seating at the event will be at tables of ten.
Please register via the following link: http://www.kenes.com/igcs-11/reg.asp
Kenes International / IGCS-11 17 Rue du Cendrier, PO Box 1726 CH-1211, Geneva 1, Switzerland Tel: +41 22 908 0488 Fax:+41 22 732 2850 E-mail: email@example.com


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Long-term Efficacy and Safety of V0034 CR 01B Cream in Patients With Moderate-to-severe Uremic Xerosis
This study has been completed.
Information provided by:
ClinicalTrials.gov Identifier:
First received: March 9, 2010
Last updated: NA
Last verified: March 2010
History: No changes posted
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Primary objective:
To demonstrate the long-term efficacy (response to treatment during initial therapy, time to relapse without treatment, durability and lesional recurrence during maintenance therapy) of V0034 CR 01B cream on uraemic xerosis in the real-life setting.
Secondary objectives:
- To assess the local tolerance of V0034 CR 01B after long-term use
- To assess the patient benefit and acceptability of V0034 CR 01B
Condition | Intervention | Phase |
Uremic Xerosis |
Drug: V0034CR01B Drug: V0034CR01B vehicle |
Phase 3 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Double-Blind Primary Purpose: Treatment |
Official Title: | Long-term Efficacy and Safety of V0034 CR 01B Cream in Patients With Moderate-to-severe Uremic Xerosis |
Further study details as provided by Orfagen:
Primary Outcome Measures:
- Long-term efficacy of V0034 CR 01B cream on uraemic xerosis in the real-life setting. [ Time Frame: 49 days ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Local tolerance of V0034 CR 01B after long-term use and patient's benefit and acceptability of V0034 CR 01B [ Time Frame: 133 days ] [ Designated as safety issue: Yes ]
Enrollment: | 236 |
Study Start Date: | January 2007 |
Study Completion Date: | March 2009 |
Arms | Assigned Interventions |
Experimental: V0034CR01B
Drug: V0034CR01B |
Placebo Comparator: V0034 CR 01B vehicle
Drug: V0034CR01B vehicle |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Inclusion Criteria:
- Patients of both sexes, of at least 18 years of age
- Women of childbearing potential having a reliable contraceptive method
- Patients undergoing maintenance renal dialysis (MRD), i.e. either haemodialysis or peritoneal dialysis, due to chronic renal failure
- Patients whose xerosis is related to their renal insufficiency status (uraemic xerosis)
- Patients suffering from xerosis with a severity score of at least two, on at least one of the five tests areas (right lower leg, left lower leg, forearm with no arterio-venous shunt, chest, dorsum of the neck)
Exclusion Criteria:
- Patients under 18 years of age
- Women with childbearing potential having a positive pregnancy test at baseline
- Patients undergoing renal dialysis for another reason than chronic renal insufficiency
- Patients whose xerosis is due to another reason than their MRD status
- Patients suffering from mild xerosis (i.e. score less than two on all the xerotic test areas)
- Patients with a known history of allergy to one of the ingredients contained in the test product
- Patients with an intercurrent condition which may interfere with a good conduct or the study parameters of the study
- Patients treated with any other emollient/moisturising topical preparation within the seven days prior to study entry
- Patients who participated in a study within the three months prior to study entry
- Patients who are not affiliated to health insurance
- Patients who are not able or willing to follow the study instructions -
Contacts and Locations
No Contacts or Locations Provided
More Information
No publications provided
ClinicalTrials.gov processed this record on March 12, 2014
No publications provided
Responsible Party: | Dr Patrick DUPUY, MD, ORFAGEN |
ClinicalTrials.gov Identifier: | NCT01084148 History of Changes |
Other Study ID Numbers: | V00034 CR 308 ORF |
Study First Received: | March 9, 2010 |
Last Updated: | March 9, 2010 |
Health Authority: | France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis) Germany: Federal Institute for Drugs and Medical Devices Greece: MINISTRY OF HEALTH AND SOCIAL SOLIDARITY NATIONAL DRUG ORGANIZATION (EOF) Hungary: National Institute of Pharmacy Latvia: State Agency of Medicines Poland: Office for Registration of Medicinal Products, Medical Devices and Biocidal Products Czech Republic: State Institute for Drug Control |
ClinicalTrials.gov processed this record on March 12, 2014


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[Warning: This story contains major spoilers from Sunday's midseason finale of Revenge. Read at your own risk!]
Revenge returns in January for three episodes before going on hiatus again until March. Here's a peek at new storms heading to the Hamptons.
- Charlotte (Christa B. Allen) moves...read more
In a glass-framed Palos Verdes, Calif., chapel on a hill overlooking the Pacific Ocean, the cast of ABC's Revenge has gathered for the wedding of Emily Rebecca Thorne (Emily VanCamp) and Daniel Edward Grayson (Josh Bowman), which will air on the Dec. 15 midseason finale. "From the moment we met, I knew this was in our destiny," the bride tells her betrothed in front of a congregation that includes best man Conrad (Henry Czerny) and maid of honor Charlotte (Christa B. Allen). "Thanks for letting me into your life...into your family. Today we share a bond that's unbreakable. Till death parts us..."
Penance - Sneak Peek
Revenge sneak peek.
Revenge - Sneak Peek
More Clips & Interviews
A dazzling film about a nightclub owner who gambles everything when he looks deeper into his father's death.
Chaz Davenport is a dashing bachelor who owns what promises to become the hottest new nightclub in town - if only the lights would stay on. Surrounded by the sumptuous blues music he adores, and with his pick of the gorgeous women who perform their sensual dance numbers onstage every night, Chaz is the envy of every man. But with the city thrown into darkness by frequent blackouts and a menacing loan shark closing in, Chaz is in danger of losing the club - and far more. At the same time, he finds himself embroiled in a love triangle with the club's alluring star singer, Crystal, and a new arrival at the club - the mysterious and seductive chanteuse Madelaine. When people close to Chaz begin turning up dead, he doesn't know where to turn or whom to trust. And the harder he tries to uncover the truth, the further he's drawn into the darkness of lies and betrayal - a darkness as black as the city's streets during yet another power outage. Welcome to the Blues.
More Gabriel Mann Movies Videos
Emily's mysterious blackouts put everything and everyone she loves at risk. Also Available On Hulu Plus, Xfinity, Amazon Instant Video and VUDU
Emily's instability puts everything she has worked for at risk. Also Available On ABC, iTunes, Amazon Instant Video and VUDU
Enemies circle as Emily is more lost than ever; a game-changing revelation leads to a new path of destruction. Also Available On ABC, iTunes, Amazon Instant Video and VUDU
The Graysons try to protect their own, as suspicion grows about the shooting of Emily Thorne. Also Available On ABC, iTunes, Xfinity, Amazon Instant Video and VUDU
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Wow! I never saw that coming. On the Nov. 17 episode of Revenge, Amber Valletta's Lydia Davis returned from the dead after presumably perishing in a plane crash at the end of Season 1. Turns out no one was more surprised that Valletta, who was given no indication that Lydia would ever return after shooting her last episode in early 2012.
After what many considered a disappointing sophomore season, Revenge's new showrunner is taking the show back to basics.
"Last season was very much about destiny, but it got pulled into so many different worlds and got so big and spectacular. So our goal this year is to really take a breath, slow it down and catch up with our characters where they are from where the season ended," executive producer Sunil Nayar tells TVGuide.com. "We're bringing everything back to the world of the Hamptons, and [we] really embrace the lush romance and the intrigue that is the Hamptons."
Arrested Development fans have had the catchy pop confection "Getaway" stuck in their heads for a month, ever since Netflix released the show's Season 4 episodes. But there has been no official way to download the track — until now.
Arrested composer David Schwartz tells TV Guide Magazine that he's now working on a full-length version of "Getaway," part of a long-awaited Arrested Development soundtrack. Schwartz is currently putting together the soundtrack, which is expected to include both songs and score from all four seasons of the cult favorite comedy.
Whose days are numbered on Revenge? Viewers will find out by the end of Sunday's two-hour season finale.
"For the first time, one of our core cast members will not survive the season," executive producer Mike Kelley tells TVGuide.com.
As the season winds down, The Initiative is kicking its plan into high gear, staging a city-wide blackout that signals that something major is about to go down. But who is the group's target? And will the death be by its hands? Or will the victim — and the killer — come as a complete surprise? We rank each of the main cast members' odds for demise.
Not an episode of Revenge goes by without at least one shocking backstab or well-played plan. It's no surprise, then, that game playing comes naturally to the three hunks who have spent the last two seasons competing for Emily Thorne's (Emily VanCamp) attentions on ABC's addictive drama.
You might be also interested in the following websites:


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CHARLESTON, W.Va. - Riverside's one-run defeat to Hurricane in the Ed Carter Memorial Tournament isn't indicative of how close the Warriors are to one of the Kanawha Valley's best programs.
That remains, however, one of their goals.
"We're making two or three mental mistakes defensively that cost us a couple runs and two or three mental errors offensively that cost us runs," said third-year Riverside Coach Chris Hawkins. "If you throw strikes and eliminate mental mistakes, you win games and then you'll see other teams making those mental mistakes."
Riverside is sitting at 6-8 and on a three-game losing streak. The Warriors won their first three games of the season, but were favored in every one - against Ravenswood, Beckley and Sherman.
They are averaging more than two errors per game and have surrendered 21 unearned runs.
In Friday's 10-2 loss to George Washington, starting pitcher Cam Norris held a 2-1 lead until the fifth inning when the Patriots scored four runs - after Norris got the leadoff batter to pop out.
In the sixth, GW scored five more beginning with a Tanner Sorrells home run to start the inning, helping Norris' earned run average balloon to 8.47.
Later Friday, they dropped a 3-2 decision to Hurricane and, on Saturday, lost 8-7 to St. Albans at Loftis Field.
None of this is overly concerning to Hawkins, who, at 26 years old, is one of the state's youngest head coaches.
"I'm not thrilled that we're 6-8," he said. "I thought we would be a lot further along. But, at the same time, I'd rather see us get hot at the end of the season. You look at Hurricane. Last year they were hot all year long and then hit a wall in the sectionals."
No starters for Riverside are batting higher than .400 and the Warriors have just two home runs.
Senior Tyler Hall has been Riverside's model of consistency. He's batting .359 with a team-leading 11 RBI and is only one of two starters who have walked (7) more times than he has struck out (5). The other is Derik Chestnut with 10 walks and 8 strikeouts. Leadoff hitter Trevor Rumberg is second on the team in walks with nine.
On the mound, Hall is 2-2 with 40 strikeouts, nine walks and a 2.39 earned run average in 291/3 innings.
* * *
NITRO COACH Steve Pritchard is the first one to admit his team just isn't very good right now.
"Are we making dumb mistakes? Yea," said Pritchard, whose team is 9-4 but has won three consecutive games. "We made them all year. Five out of our first seven outs (against Logan) were dumb mental mistakes. I'm just going to call them. They're dumb."


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Johnny Rocket_486
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Hi everybody! I noticed that this thread didn't have much recent activity. So, I thought I'd post some pics. of my 0-6-0 logging tank engine. Maybe these will inspire some builders to show off their mining/logging creations! |
Steve Jackson
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re: Backwoods 0-6-0Pretty! (That's about as constructive as I can be right now . . .) |
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New York Young Republicans Prepare to Unite, Maybe
The New York City Young Republican club split in two so long ago—all the way back in 1991—that the story of the schism is institutional legend. It had to do with state affiliation and interpersonal rivalries; the details (recounted by The Observer here) are sordid and ultimately trivial. They now maintain separate web Read More


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SOG FastHawk Tomahawk
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back to topProduct Description
Branches in your path are no match for you when you carry this Folding Hand Saw. Self-sharpening blade is made of durable tempered spring steel. Cross cutting design allows sawing in both directions. Self locking handle is made of high impact plastic. Open length: 19" Blade length: 9" Closed length: 11".


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Child Field Workers: Who's Picking Your Food?
It's a fact many Americans don't think about when shopping for their dinner table. Children as young as 8 years old may be picking their food.
From Florida to Washington, California to North Carolina, children across the country have been working the fields, harvesting cucumbers, onions, grapes, and even tobacco.
As part of CNBC's investigation into child labor in agriculture, we went undercover to a tobacco farm in North Carolina and spoke with several kids who worked in the fields. They said even though it's their choice to work, it's a choice made out of economic necessity.
"My mother, I knew that she was working since whenever we were really young, but she never exposed us to this kind of work. It wasn't until afterwards that the need to help my mom and the fact that she was a single mom with four or five kids at the time, so we decided we should help," explained 20-year-old Yesenia Cuello, who has worked in tobacco fields since she was 12.
Other children we spoke with also told us they work in the fields to help their families make ends meet.
"I am going to save my money, and when I need it, like for an emergency, I am going to use it. Like when somebody pass[es] out from my family. I use it. My grandpa passed out, and I was sad. I like helping my family because they need money," explained a 12-year-old boy, who just started working in the fields this year.
Cuello said she only works in tobacco now when her Mom is planning to go in the fields alone. She prefers her job at McDonald's .
And that's the irony. U.S. labor law, under the Fair Labor Standards Act (FLSA), allows for children as young as 10 to work in the fields with parental consent and as long as the work is not considered hazardous under the law. However, children are not allowed to work at McDonald's or in a grocery store until the age of 16.
The FLSA has not been updated since the 1970s and farmworker advocates say the law lacks proper protection for children in certain agriculture work environments.
"What we know about pesticide exposure has changed. There's new technology. And it's time for that list to be updated," said Zama Coursen-Neff, director of the Children's Rights Division for Human Rights Watch.
In 2011, the U.S. Department of Labor proposed updates to child labor regulations that would have prohibited youth under 16 from using certain types of machinery, lowered the maximum height for ladders youth could use to pick apples and labeled working in tobacco "hazardous."
However, those proposed changes were withdrawn in April after overwhelming public comment on the issue. Because America's agriculture industry has been built on family farms, critics feared the regulations would overreach and eventually ban children from working on their own family farms.
The exact number of child farmworkers is difficult to pinpoint due to the lack of data on child labor and the migratory nature of the work. One advocacy group, the Association of Farmworker Opportunity Programs (AFOP), which partners with non-profit community programs nationwide, estimates as many as 500,000 children are laboring in U.S. fields. It said poverty is the root cause of the problem.
"Unfortunately what ends up happening is that because these kids that are out there trying to help out their families, they have huge impacts to their health, education and their childhood which ends up perpetuating the cycle of poverty that they are trapped in that their parents were tapped in," said Norma Flores Lopez, Director of the Children in the Fields Campaign at AFOP.
"Many factors to consider" when it comes to child labor
Lee Wicker, Deputy Director of the North Carolina Growers' Association (NCGA) and a tobacco farmer, admits there are many factors to consider when it comes to children working in agriculture.


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Marv Garriott stayed up all night Monday, trying to figure out a way to keep his authentic 1950s soda shop and diner in Black Diamond open.
While the restaurant was not directly affected by the June floods, a large portion of Highway 22 connecting Turner Valley and Black Diamond was washed out in the flood, keeping visitors from Marv's Classic Soda Shop for weeks.
"We lost pretty much all of that traffic that would travel through here normally," Garriott said.
Business at the tourist destination — home to what Garriott believes is the only operating antique soda fountain in Canada — was down 70 per cent in July compared to July 2012, and down 40 per cent in August. Even before the flood, business was slower than previous years.
Now, bills are piling up and 68-year-old Garriott is worried he will have to close the shop, which has been a fixture in the town 40 kilometres south of Calgary for years.
On Monday night, Garriott researched realtors online.
"(Selling) it would be a very, very last resort for me. I've put my heart and soul into this place," he said.
For 13 years, the shop has served ice cream, sweets and homemade burgers and fries, sourced from local farms, to customers from around the world.
Located on main street, the shop indulges Garriott's love of the 1950s. From the jukebox to the authentic photos and other nostalgic memorabilia, it serves as a walk down memory lane for visitors.
"Our business is a unique business and probably one of a kind in the country," Garriott said.
While business typically slows down in winter — July and August are Garriott's two busiest months — Garriott believes an influx of tourists in the coming months could keep him from closing the doors.
"It won't take a lot to turn around, we just need some travelling on the weekends out here," he said.
If not, like the memorabilia it houses, the shop will become a thing of the past, something Garriott desperately hopes won't happen.
"This is home for me. Everything that I care about in my life is in here," he said.


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Sansom Park is located in Texas. Sansom Park, Texas has a population of 4,686. Sansom Park is less family-centric than the surrounding county with 34.93% of the households containing married families with children. The county average for households married with children is 35.82%.
The median household income in Sansom Park, Texas is $32,819. The median household income for the surrounding county is $56,532 compared to the national median of $50,935. The median age of people living in Sansom Park is 30.3 years.
The average high temperature in July is 97 degrees, with an average low temperature in January of 34.5 degrees. The average rainfall is approximately 35.2 inches per year, with 2.5 inches of snow per year.
Real Living Real Estate Group Serving Greater DFW Metro Dallas, TX (855) 668-4000 Real Estate Agents & Staff


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Open AccessThis article is
- freely available
- re-usable
Int. J. Mol. Sci. 2013, 14(3), 4545-4559; doi:10.3390/ijms14034545
Cesium Inhibits Plant Growth through Jasmonate Signaling in Arabidopsis thaliana
RIKEN Plant Science Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
* Author to whom correspondence should be addressed.
Received: 25 December 2012; in revised form: 25 January 2013 / Accepted: 6 February 2013 / Published: 25 February 2013
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
Download PDF Full-Text [2336 KB, uploaded 25 February 2013 14:48 CET]
Abstract: It has been suggested that cesium is absorbed from the soil through potassium uptake machineries in plants; however, not much is known about perception mechanism and downstream response. Here, we report that the jasmonate pathway is required in plant response to cesium. Jasmonate biosynthesis mutant aos and jasmonate-insensitive mutant coi1-16 show clear resistance to root growth inhibition caused by cesium. However, the potassium and cesium contents in these mutants are comparable to wild-type plants, indicating that jasmonate biosynthesis and signaling are not involved in cesium uptake, but involved in cesium perception. Cesium induces expression of a high-affinity potassium transporter gene HAK5 and reduces potassium content in the plant body, suggesting a competitive nature of potassium and cesium uptake in plants. It has also been found that cesium-induced HAK5 expression is antagonized by exogenous application of methyl-jasmonate. Taken together, it has been indicated that cesium inhibits plant growth via induction of the jasmonate pathway and likely modifies potassium uptake machineries.
Keywords: cesium; potassium; Arabidopsis thaliana; jasmonate; HAK5
Supplementary Files
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Supporting Information (DOCX, 167 KB)
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MDPI and ACS Style
Adams, E.; Abdollahi, P.; Shin, R. Cesium Inhibits Plant Growth through Jasmonate Signaling in Arabidopsis thaliana. Int. J. Mol. Sci. 2013, 14, 4545-4559.
AMA StyleAdams E, Abdollahi P, Shin R. Cesium Inhibits Plant Growth through Jasmonate Signaling in Arabidopsis thaliana. International Journal of Molecular Sciences. 2013; 14(3):4545-4559.
Chicago/Turabian StyleAdams, Eri; Abdollahi, Parisa; Shin, Ryoung. 2013. "Cesium Inhibits Plant Growth through Jasmonate Signaling in Arabidopsis thaliana." Int. J. Mol. Sci. 14, no. 3: 4545-4559.
Int. J. Mol. Sci.
Published by MDPI AG, Basel, Switzerland
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