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Preheat the pan on top of the grates, add chopped veggies or fruit, and grill alongside the main entree. Fits all Weber charcoal, gas, and electric grills.
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Well 2013 they started banning players along with hackers. gg, If your looking for a good mmorpg this isn't it. The economy is in the millions billions which means to be good in here you got to spend more then a regular paying mmorpg. 5x more to be more exact. If you like repetitive gameplay with 8-13 year olds and pedofiles this is your game.
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I miss the old Maplestory from 2006-2010. After that it got wrecked. I tried the new-ish one but it wasnt the same. Its just ruined now. Good thing i quit.
Maplestory is really just boring to me now, I never have any.. urge to play it anymore.
Can't believe GMS got this before Korea, oh well at least we have now... Anyhow Root Abyss sucks in my opinion
@RiKanKiDD Agreed. I started in 2005 and stopped last year. Too many changes and classes. I log in once in a while just to see whats what.
Yes they do but to actually do anything now you spend about five times what you would just to play a pay-to-play MMO.

subset: commoncrawl


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Vote Now For The 2013 Hot 20
We asked you to tell us about the Bay Area's coolest, best, and brightest. Now, we've narrowed the field down to the Top 20 and it's time to vote!
Whoever receives the most votes will be added to 2013's prestigious list of honorees with an advertorial in the October issue! Who do you think deserves to be in this year's Hot 20? VOTE at the end of the post! One lucky voter will also win a pair of tickets to our annual Hot 20 issue launch party!
Sherri Franklin - The founder and leader of Muttville Senior Dog Rescue, Sherri has dedicated her life and home to saving homeless and often unwanted senior dogs and helps them find new homes.
Jake Wall - Co-founder and chief designer of the Artful Gentleman, Jake is rethinking fashion in San Francisco. He blurs the lines around gender by creating custom suits and style for the City's men, women, and gender-queer. Not only a fashion innovator, Jake is also a huge supporter of the LGBT community.
Béatrice Amblard - A master leather artisan, Béatrice owns April in Paris, where she handcrafts custom accessories using centuries-old traditional methods. Best known for her gorgeous handbags, she is the only Hermés artisan designing under her own label in the United States.
Dave Kleinschmidt - "The Schmidt" went from booking some of the hottest artists to becoming one of the hottest up-and-coming DJs. In addition to creating good vibes all over the city, he donates his time and energy to various philanthropic events.
Lisa Lee – Lee is changing the way Asian-American women deal with body image through her website Thickdumplingskin.com. Along with colleague and actress Lynn Chen, she's devoted to fostering positive body image within the Asian-American community through reader-submitted photos and essays, interviews, and their own thoughts on food and body image. To help build an audience, they promote the site on Twitter and Facebook—where Lee works as a diversity program manager. She's won praise from the national press, including NPR and Marie Claire.
Joe Landini - Founder and director of The Garage in SoMa, an independent theater that offers free space to women and LGBT artists, Joe is also an innovative programmer and anchor of the dance community, bringing in some of the best new talent in the Bay Area dance scene.
Avital Ungar - An expert in the cocktail and food industry, Avital founded Avital Tours, a series of neighborhood behind-the-scenes culinary tours that give locals and tourists back door access to some of the best food and drink spots in the city.
Corey Rosenberg - Cory has an impressive resume. He boasts many years of ad copywriting, teaches advertising, and authored The Gay Man's Guide to Timeless Manners and Proper Etiquette. Cory also co-founded of Horizons Young Professionals for Equality (HYPE) a charitable organization that makes philanthropy accessible to young professionals in the Bay Area.
Rebecca Alonzi - Ever been to a great company party or wedding that had unforgettable food, drinks, and ambience? Rebecca Jean Catering probably made it happen. This gal and her team creates eats (and does event planning!) for high-profile clients such as GAP, Pinterest, Google, Square, as well as weddings and other private soirees.
Gi Paoletti - Gi is a talented architect and designer and owner of Gi Paoletti Design Lab, a firm with a well-rounded portfolio of residences and commercial spaces in the Bay Area including Bloodhound Bar, Noir Lounge, the Tipsy Pig, and Maven.
Kyle Itani - Kyle is a phenomenal, passionate chef who truly highlights the diverse food culture of the Bay Area at his massively popular Oakland restaurant Hopscotch. His experimental, Japanese-inspired American food has garnered praise from the press, and has helped make uptown Oakland a vibrant place to play.
Ryan Nolan / Ry Toast - Ryan is a hip hop DJ who combines her turntablism with yoga– to her, yoga and hip-hop are inextricably linked, like an urban yin and yang. This musically blessed gal puts her heart into her work, gets the party started, and helps the masses toughen and tone their bodies and souls.
Casey Chafkin - Casey is the co-founder of Skillz Gaming, the world's first cash tournament SDK, designed to make gaming more fun and game development more profitable. His innovative product can be integrated into almost any mobile game, enabling an added layer of tournament play which allows gamers to play their favorite games for cash and prizes. He definitely embodies a Bay Arean who is disrupting an entire industry.
Julianne Morales Walsh - Julianne knows what's important to San Franciscans: their pets and a sense of eco-friendliness. As the founder of GreenPawz, Julianne has built her company into the only certified green pet boutique in the city, and it's garnered legions of fans for its expert dog grooming practices.
Kais Bouzidi - Owner of Sens restaurant since he was a mere 22 years-old, the native Frenchman operates one of the most successful (and gorgeous) happy hour spots with one of the best views in the Financial District.
Andrew Grauer - Grauer is helping us all expand our minds as the founder of Course Hero, a website of study guides, class notes, flash cards, tutoring services, and courses for college students. At 26, Andrew is the CEO of Course Hero, a Bay Area start-up with an impressive mission: making education more accessible. Can't argue with that!
Brad Goya - As the owner of SF Green Spaces, this SF native beautifies our gorgeous city with his landscape design and construction company. His work emphasizes self-sustainable, sensible, and stylish design and landscaping, superior construction, high quality and environmentally-friendly materials. His incredible work covers all corners of the city.
Adam Fong – Adam leads the Emerging Arts Professionals, a network focused on empowerment, leadership, and growth of next generation arts and culture workers in the Bay Area, with passion, creativity, and humility. He helps foster a sense of cultural diversity that manifests itself as art all over our city.
Daniela Lencioni - An SF native born and raised in the Mission, Daniela is an artist and designer who creates handmade pieces for the men's accessory line and lifestyle brand Noble Breed.
Karl the Fog - The oldest of the Hot 20 nominees, Karl has been gracing San Francisco with its presence on an almost daily basis for longer than anyone has lived in San Francisco. Most prominent in the summer months, the Fog has a rampant Twitter and Facebook following as well as its own website.
Voting ends at 5 p.m. on Wednesday, July 31.
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- Also Known As:
- Novotel Paris Les Halles Hotel Paris
- Novotel Paris Les Halles Hotel
- Accor Paris Les Halles
- Novotel Paris
- Paris Novotel
Phone Number:
France >
Ile-de-France >
> Louvre / Place Vendôme
Business Center
Room Service
Shuttle Bus service
Wheelchair access
#236 Luxury Hotel in Paris
#271 Family Hotel in Paris
Price Range (Based on Average Rates):
Hotel Class:4 star — Novotel Paris Les Halles 4*
- Official Description (provided by the hotel):
- The Novotel Paris Les Halles is a 4 star hotel in the centre of Paris with direct Metro and RER train connections to Charles de Gaulle and Orly airports, the major train stations, Disneyland Paris and major Paris attractions including the Pompidou Centre, the Louvre, Notre Dame and more. The hotel offers 285 rooms, nine meeting rooms for conferences and seminars. Ideal for a business trip or holiday in Paris, the hotel also features a bar, restaurant and a quiet patio to ensure you a pleasant stay. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Booking.com, Hotels.com, Orbitz, Travelocity, ACCOR, Priceline, Tingo, Agoda, getaroom.com, Otel and Venere so you can book your Novotel Paris Les Halles reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


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The Department of Theatre in the College of Fine Arts offers programs in performance, production and technology taught by experienced faculty, while taking advantage of the entertainment richness of Las Vegas.
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- Mar. 8Eurydice
- Mar. 8Eurydice
- Apr. 4Five Women Wearing the Same Dress
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2013-2014 Season
Enjoy great plays from the classics to the contemporary. Subscription now available.


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Logo design for We Own Rotterdam
Thursday, 12 April 2012 15:25
Some time ago I made an illustration and a logo design for We Own Rotterdam, which is a very useful website if you want to go out in Rotterdam but need some ideas for where to go. They finally uploaded my illustration and the logo I made for them and I'm very proud to be a part of their website now. Go check it out:
Something equally awesome, is the postcards they printed with my illustration on it! I can't wait to get my hands on some of these.
By the way, I got the photo below from Florian's Instagram stream. He's one of the founders of We Own Rotterdam, so maybe you can go check him out.


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MPN: UE32F4510AWXXH The great value Samsung UE32F4510 TV gives you first-rate entertainment, including internet access and a full range of TV catch-up services.The 32 inch screen has a 1366 x 768p resolution, dual core processor and LED backlighting to create beautifully lifelike images and stunning detail. Built-in WiFi lets you access Samsung Smart Hub technology, your gateway to an online world of internet TV – perfect for big screen browsing. Enjoy social networking sites such as Twitter and Facebook, customise your set with apps, explore YouTube and much more. You also get all the catch-up TV services, including the BBC iPlayer, ITV Player and 4OD. S Recommendation suggests things for you watch based on your viewing habits and it'll then show you the relevant TV listings. You can also use the Samsung UE32F4510's USB ports to enjoy music, video and photos from other digital devices or wirelessly stream content via WiFi from compatible devices via AllShare Play, including PCs and laptops. A built-in Freeview HD tuner offers access to a range of free-to-view high definition channels, including BBC HD, ITV HD and C4 HD. Useful info:
View all Samsung products | |
Offer: HALF PRICE HDMI CABLE OFFER


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The Westin Boston WaterfrontDog-Friendly Hotels425 Summer StreetBoston,Massachusetts 02210Call 866-676-3077 To Book This Hotel Get Map or Directions Explore the exciting city of Boston from the AAA Four Diamond Westin Boston Waterfront. Were less than three miles from Logan International Airport (BOS), and a short cab, water taxi, or T train ride away from Back Bay, the Financial District, and family attractions such as the New England Aquarium and the Boston Childrens Museum. Connected to the Boston Convention & Exhibition Center (BCEC)-New Englands largest convention center-The Westin Boston Waterfront is an ideal location for your next business function. The hotel itself offers a total of 70,000 square feet of meeting space, including the 15,000-square-foot Grand Ballroom and 8,500-square-foot Harbor Ballroom. Our additional 19 meeting breakout rooms will accommodate groups of five to 150. Parking is available onsite, for a fee, for up to 250 cars. When work is done, rejuvenate body and mind in our WestinWORKOUT? Fitness Studio, and enjoy a delicious meal in our dining room, Sauciety. Our 793 guest rooms and suites reflect Westins soothing aesthetic. Rest in the signature Heavenly Bed? and enjoy the flat-screen TV and wireless High Speed Internet Access. Our Heavenly Bath? is the perfect place to refresh. We also provide slippers and bathrobes to make your stay with us even more relaxing.The only hotel connected to the Boston Convention Exhibition Center via a sky-bridge, this upscale business and leisure destination offers a variety of amenities and a wonderful waterfront location. Dogs are allowed for no additional fee; there is a pet waiver to sign at check in.
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Who actually really owns your Samsung T101G?
You? I mean you did pay anywhere from 100 - 800 USD for your Samsung T101G right?
Think again, if your T101G is simlocked it is in fact still property of your telecom provider and you are not free to do with the mobile as you want. So, we say, its time for Mobile Freedom! Take ownership of your Samsung T101G and sim unlock your phone or tablet right now.
Don't delay - free your Samsung T101G from all simlock restrictions now


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It's not just kittehs that love captions! ALL THE ANIMALS DO! Check out Animal Capshunz for MOAR!
You don't need to open Pandora's Box It will open all by itself
PANDORA'S RULE Never open a box you didn't close.
Jimmy Kimmel Asks the People of Austin, Texas if They're ...
18 Unlucky Moments with Lucky Animals
Pretty Sure She's Not Under Anyone's Radar
Walter Has Been Writing His Own Obituary for Years, and It's ...
Now You See This Pool, and Now You Don't!
They'll Be Together Forever
Winter Ain't Over Yet
McDonalds Cannot Into Math
These Comments Are the Absolute Pinnacle of First World Problems
Something Special Happens When You Put Dogs in a Photobooth
Pick Your Site Name
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The Beacon
Fantastic and Made of Plastic (Part Duex)
Further evidence that octopuses are among the most, if not the most intelligent invertebrates around: Meet Louis the giant Pacific octopus posing in this pic with his new pal Mr. Potato Head. According to the article, "Octopuses are very intelligent and they like to be stimulated and busy."
If things don't work out for Louis and Mr. P in the end, though, I know of a lonely 8-foot-tall Lego man that may be in need of a friend. ...


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Orange Tree Villa - Apartment Rentals in Scottsdale, AZ
Orange Tree Villa Apartments Description
Come join our Scottsdale Apartments community at Orange Tree Villa Apartments. If a great location is what you want, you have found the right place to call home. We are located within minutes of Old Town Scottsdale AZ, Scottsdale Fashion Square Mall and Scottsdale Waterfront. Enjoy night life? You may not run out of fun places to visit, dance, sing, mingle, etc.
There is easy access to the 101 loop as well. Orange Tree has spacious one and two bedroom floor plans with huge walk in closets. Concrete walls aid in soundproofing and ensure your privacy.
Among our many features include an abundance of counter, cabinet and closet space. Also enjoy our clubhouse, sparkling swimming pool and lush landscaping. There is one covered parking spot per unit and laundry facility for your convenience. We also have 24-hour on call maintenance for emergencies. So come on down and check out our beautiful, inviting community. You'll love it! Please call for an appointment today.
Pet Policy
Cats and Dogs are allowed. Maximum weight of pet(s): 100. Restrictions or other terms: Pets welcome up to 100 lbs! No Pet Rent! Call for details! Call for details. Breed restrictions apply..
- Pool
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Orange Tree Villa
4181 N Granite Reef Rd
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The Hotel De Ela is a quality hotel in Berlin, Germany. Centrally located near the U-Bhan and within walking distance of favorite attractions in Berlin yet in a quiet area, the Hotel De Ela is a perfect choice for business and leisure travelers visiting Berlin. Hotel De Ela is housed in a historic building that features a pleasant mix of classic German architecture and contemporary style. While staying at Hotel De Ela, you can start your day with a delicious breakfast in the breakfast room before heading out to sightsee in Berlin. From the Hotel De Ela, guests can easily access nearby restaurants, cafes, pubs, nightlife, and entertainment venues. There is also a nearby grocery store. With the U-Bhan station being within walking distance of the hotel, all of the attractions in Berlin are within reach. Guests can enjoy the complimentary unlimited wireless Internet and parking as well as bicycles for rent at the hotel and on-site dry cleaning and laundry service.
Show reviews
Internet: | Wired Internet, Wi-Fi Internet connection |
Parking: | Parking Nearby |
Rooms: | 16 |
Services: |
General facilities: |
Extra common areas: |
Business facilities: |
Important information & conditions: | KaDeWe - 0.9 km / 0.5 mi Kaethe Kollwitz Museum - 1.2 km / 0.7 mi Europa Center - 1.2 km / 0.7 mi Kaiser Wilhelm Memorial Church - 1.2 km / 0.8 mi The Story of Berlin - 1.4 km / 0.9 mi Theatre of the West - 1.4 km / 0.9 mi Berlin Zoo - 1.6 km / 1 mi Bauhaus Archive - 1.7 km / 1.1 mi Technical University - 2.3 km / 1.4 mi Gleisdreieck Park - 2.3 km / 1.4 mi Gemaeldegalerie - 2.4 km / 1.5 mi Victory Column - 2.4 km / 1.5 mi New National Gallery - 2.4 km / 1.5 mi Schaubuehne - 2.5 km / 1.6 mi Berlin State Library - 2.6 km / 1.6 mi The closest major airports to Hotel De Ela are:Berlin (TXL-Tegel) - 7 km / 4.4 miBerlin (SXF-Schoenefeld) - 16.6 km / 10.3 miThe preferred airport for Hotel De Ela is Berlin (TXL-Tegel). Distances are calculated in a straight line from the property's location to the point of interest or airport and may not reflect actual travel distance. Distances are displayed to the nearest 0.1 mile and kilometre. |
Cancellation policy: | You can change or cancel this deal free of charge up to 48 hours before your check-in date. Please take into account that the check-in date starts at 00:00 (local time). Free cancellation can be made up until 2 days before the check-in day. For cancellations made after this time a cancellation fee of 100% of the entire stay will be charged. All times refer to the local time at the property. For no-show, 100% of the entire stay will be charged. |
Note: It is the responsibility of the hotel chain and/or the individual property to ensure the accuracy of the photos displayed. We are not responsible for any inaccuracies in the photos. | |
Please provide this reference number to our customer service center representative on request, so we can help you better


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Art Magazines
Looking for new art magazines featuring some of the best fine art you can find? The North Light Shop has the top selection of art magazines online, with a great selection of watercolor and fine art magazines, plus the popular Pastel Journal, Southwest Art and other artist magazines. Want to get a subscription, or see more options? Please check out our art magazine subscriptions or our selection of art magazine CDs for great art and value!
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French Connection wool-blend coat is a neat ladylike silhouette. Wear with a structured tote bag and killer heels to show you mean business!
Wonderland Flared Coat is collarless and has a side-fastening button placket at front, interior button fastening, two side-slit pockets and a flared skirt. This coat is fully lined.
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School Custodian Arrested For Molesting Child
Updated: Monday, January 14 2013, 02:17 PM EST
An Upstate man who works as a custodian for a mountain school is arrested for molesting a young girl. Alfard Mullins Jr. is charged with two counts of criminal sexual conduct with a minor and two counts of incest.
According to Polk County Schools, Mullins has been employed with the district for eight years. He is a janitor at Polk County Middle School and a bus driver. Investigators say the victim is not a student at the school.
According to the initial report filed last October, Mullins started abusing a young relative in 2006. Investigators say the victim was between the ages of 11 and 14 at the time. Authorities also say the abuse happened on at least two different occasions in Spartanburg County.
The young female told authorities that on multiple occasions he inappropriately touched her and had sexual intercourse with her. He allegedly bribed the girl with money and gifts so she wouldn't tell anyone.
The school has suspended Mullins with pay, pending the results of the investigation. The school district says they plan to release a statement about his arrest at a later time. At this point in their investigation, detectives don't know if there are any other victims.
Mullins is being held in the Spartanburg County Detention Center. He will make his first appearance in front of a judge overnight.
Follow Megan Schiering on Twitter @mschieringWLOS


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While the S&P 500 is within spitting distance of topping its 2007 record high, the S&P 500 financial sector remains about 50% below its all-time high, also reached in 2007.
Bank stocks have staged an impressive comeback from the financial crisis, surging nearly 200% since the market bottomed in March 2009, and outperforming nearly every other sector.
But when it comes to reclaiming their pre-recession highs, bank stocks have a long way to go.
While the S&P 500 is within spitting distance of topping its 2007 record high, the S&P 500 financial sector remains about 50% below its all-time high, also reached in 2007.
It's true that banks are much healthier than they were in 2007, boasting higher levels of capitalization and cleaner balance sheets. Credit quality and loan demand have also shown marked improvement.
But simply put, banks are just not nearly as profitable as they once were.
Related: Actually, the real Dow is still 11% below its record
"The slow economic recovery and record low interest rates are headwinds that have been squeezing profits," said Anthony Polini, a bank analyst at Raymond James.
The U.S. bank industry's net interest margins, a gauge of lending profitability, were at their lowest level in five years at the end of last year, according to the Federal Deposit Insurance Corp.
And that's putting pressure on overall profits.
Bank of America's (BAC, Fortune 500) return on equity, a closely watched metric that measures how well banks generate profits for shareholders, stood at less than 5% last year, down from more than 10% in 2007 and nearly 20% in 2006, according to Thomson Baseline.
Related: Stress test shows banks could lose nearly half a trillion dollars
The return on equity at Citigroup (C, Fortune 500) stood at a little over 6% last year, down from 18% in 2007 and 31% in 2006. It's a similar story at Morgan Stanley (MS, Fortune 500), Goldman Sachs (GS, Fortune 500) and Wells Fargo (WFC, Fortune 500).
One standout has been JPMorgan Chase (JPM, Fortune 500), whose return on equity was near 12% at the end of 2012. But that figure may be a bit misleading. One of the reasons it's so high is because JPMorgan has had relatively low levels of capital. Any increase to that could quickly push the bank's ROE down.
On their road to recovery, banks have been cutting costs by laying off thousands of workers and reducing how much money they set aside to guard against bad loans. But that may not be enough.
KBW bank analyst Chris Mustascio says banks face new challenges from stricter regulations that come with the Dodd-Frank financial reform legislation, and the Durbin amendment, which limits fees banks can charge retailers for debit card transactions.
Mustascio expects bank stocks will perform in line with the market until earnings show marked improvement. And that won't happen until economic growth picks up and interest rates start rising, he said.
A faster-growing economy should increase the revenue banks rake in from deposit and transaction fees, while higher interest rates will lift the income banks receive from making loans.
Index | Last | Change | % Change |
Dow | 16,418.68 | -34.04 | -0.21% |
Nasdaq | 4,334.45 | -1.77 | -0.04% |
Treasuries | 2.78 | -0.01 | -0.22% |
Company | Price | Change | % Change |
Bank of America Corp... | 17.47 | 0.14 | 0.81% |
Facebook Inc | 72.03 | 0.01 | 0.01% |
Verizon Communicatio... | 47.03 | -0.12 | -0.25% |
Ford Motor Co | 15.51 | -0.11 | -0.70% |
Cisco Systems Inc | 21.69 | -0.04 | -0.21% |
Overnight Avg Rate | Latest | Change | Last Week |
30 yr fixed | 4.36% | 4.32% | |
15 yr fixed | 3.38% | 3.34% | |
30 yr refi | 4.37% | 4.30% | |
15 yr refi | 3.37% | 3.32% |
Today's featured rates:


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Reviewed by 1 customer
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These pants rock. 5'5"ish, 118 lbs, I got a size three and I love them. Butt pockets are flattering, the design on the side is so cool, and they are comfortable which is sometimes hard to come by with skinny jeans. Only thing is that they're a little long on me, but I cuff them and they look just as cute.
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Impact of SH T00658ID as Compared to a Monophasic Contraceptive Containing Ethinylestradiol and Levonorgestrel (SH D01155E) on Hemostatic Parameters
This study has been completed.
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: April 26, 2006
Last updated: November 20, 2013
Last verified: November 2013
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- How to Read a Study Record
Detailed Description:
The aim of this study is to evaluate the impact of SH T00658ID (EV/DNG tablet) on hemostatic parameters in comparison to a reference oral contraceptive (OC) (SH D01155E) in a crossover design.
Condition | Intervention | Phase |
Pregnancy, Unplanned |
Drug: EV/DNG (Qlaira, BAY86-5027, SH T00658ID) Drug: SH D01155E |
Phase 2 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Endpoint Classification: Safety Study Intervention Model: Crossover Assignment Masking: Open Label Primary Purpose: Prevention |
Official Title: | A Single-centre, Open-label, Crossover, Controlled, Randomized Study to Investigate the Impact of SH T00658ID as Compared to a Monophasic Contraceptive Containing Ethinylestradiol and Levonorgestrel (SH D01155E) on Hemostatic Parameters in 30 Healthy Female Volunteers Over 3 Treatment Cycles |
Resource links provided by NLM:
Further study details as provided by Bayer:
Primary Outcome Measures:
- Intraindividual absolute changes from Baseline in the Parameters of thrombin and fibrin turnover [ Time Frame: Baseline, Cycle 3 of each treatment period ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Intraindividual absolute changes from Baseline in Pro- and anti-coagulatory parameters and the parameter of thrombin and fibrin turnover (activation marker): Prothrombin (Factor II). [ Time Frame: Baseline, Cycle 3 of each treatment period ] [ Designated as safety issue: No ]
- Adverse events [ Time Frame: 2 treatment periods (3 cycles each), 2 cycles whash out-period and 14 days follow-up period ] [ Designated as safety issue: Yes ]
Enrollment: | 29 |
Study Start Date: | April 2006 |
Study Completion Date: | May 2007 |
Primary Completion Date: | May 2007 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Arm 1 |
Drug: EV/DNG (Qlaira, BAY86-5027, SH T00658ID)
per cycle (28 days): Days 1-2: 3.0 mg EV; Days 3-7: 2.0 mg EV + 2.0 mg DNG; Days 824: 2.0 mg EV + 3.0 mg DNG; Days 25-26: 1.0 mg EV; Days 27-28: Placebo
Active Comparator: Arm 2 |
Drug: SH D01155E
per cycle: Days 1-21: 0.03 mg EE + 0.15 mg LNG; Days 22-28: Placebo
Detailed Description:
The study has previously been posted by Schering AG, Germany. Schering AG, Germany has been renamed to Bayer Schering Pharma AG, Germany.Bayer Schering Pharma AG, Germany is the sponsor of the trial.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Healthy female volunteers
Exclusion Criteria:
- Pregnancy or lactation
- Any condition that might interfere with the outcome as all contraindications for OC use.
Contacts and Locations
More Information
Additional Information:
Keywords provided by Bayer:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 12, 2014
Additional Information:
Responsible Party: | Bayer |
ClinicalTrials.gov Identifier: | NCT00318799 History of Changes |
Other Study ID Numbers: | 91477, 2005-004688-45, 310122 |
Study First Received: | April 26, 2006 |
Last Updated: | November 20, 2013 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
Keywords provided by Bayer:
prevention of unintended pregnancies |
Additional relevant MeSH terms:
Contraceptive Agents Levonorgestrel Ethinyl Estradiol Hemostatics Reproductive Control Agents Physiological Effects of Drugs Pharmacologic Actions Therapeutic Uses |
Estrogens Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Coagulants Hematologic Agents Contraceptive Agents, Female Contraceptives, Oral, Synthetic Contraceptives, Oral |
ClinicalTrials.gov processed this record on March 12, 2014


text:
Jessica Henry and Eric Bens exchanged wedding vows on Aug. 25, 2012, at the Gerry United Methodist Church. The Rev. Rick LaDue performed the ceremony. Music was provided by Melissa Beichner, pianist.
The bride is the daughter of Christine and William Bunn of Auburn, N.Y. Her husband is the son of Philip and Laurie Bens of Gerry, N.Y.
The bride wore an A-line champagne-colored all lace gown.
Article Photos
Victoria Norling was maid of honor. Bridesmaids were Caitlin Shea and Katie Walker.
Best man was Michael Johnson. Ushers were Stephen Conti and Nathan Cobb.
Mistress of ceremonies was Ashley Bens.
The bride is a 2006 graduate of Moravia High School, earned a bachelor's degree in social work from the State University at Fredonia in 2010 and her master's degree in social work from University at Albany in 2011. She is employed as director of social services at Absolut Care of Westfield. Her husband is a 2003 graduate of Cassadaga Valley High School, earned a bachelor's degree from the State University at Fredonia and his master's degree from Western Carolina University. He is employed as human resource specialist at TitanX Engine Cooling.
They honeymooned in Chicago, Ill.
They are living in Westfield, N.Y.


text:
Dec 7, 2012, 09:44 PM | #1 |
iTunes 11 won't sync apps onto iOS devices
ever since I updated iTunes 11, when a purchase an app through iTunes on my mac, or an ipa file I manually dragged into iTunes, they don't sync onto the my iOS devices. I have selected the apps to be synced and they appear on the screen shot on the iTunes, but they just won't sync. Anybody encountering this problem? thank you |
0 |
Dec 8, 2012, 08:50 AM | #2 |
no problem here, but I don't mess with pirated apps.
0 |
Jan 24, 2013, 09:49 AM | #3 |
same here
i'm trying to install an ad-hoc app for testing from a client (so not pirated, and i think it rude to assume the OP was talking about pirated apps) and encountering the same problem
provisioning profile is all good incidentally, i also can't install apps that are in my itunes library that i had previously removed from ipad... (ie issue is not limited to ad-hoc distributions) |
0 |
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All times are GMT -5. The time now is 06:54 AM.


text:
Grand Geneva Resort Say "I Do" Photo Contest
06 Jul, 2010
Grand Geneva cherishes the memorable couples who have celebrated their love by getting married here at the Resort. We want to thank our brides and grooms by having a Say 'I Do' Photo Contest to win a free Anniversary Stay at the Grand Geneva Resort & Spa.
Starting July 1st, submit your favorite wedding day photo from Grand Geneva, with a short paragraph on why you want to celebrate your anniversary at the same place where you became husband and wife.
The winner of the best photo and story submission will win a one- night Anniversary stay, champagne and strawberries in the room, an evening dinner at the Grand Geneva Chophouse and breakfast in bed. A gorgeous flower arrangement will be awaiting you in your room upon arrival, provided by Treasure Hut Flowers. The winning couple will receive a free one-hour anniversary photo shoot at Grand Geneva with Matt Mason Photography.
To enter your photo into the contest, you must have been married at the Grand Geneva Resort. Please email your photo submission to email@example.com.
The winner will be announce August 2, 2010!
We'd like to thank our sponsors, Treasure Hut Flowers and Matt Mason Photography.
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Fall Fun at Grand Geneva


text:
The Pew Charitable Trusts is driven by the power of knowledge to solve today's most challenging problems. Pew applies a rigorous, analytical approach to improve public policy, inform the public and stimulate civic life.
The Pew Fiscal Analysis Initiative provides policy makers and the public with facts and probing analysis on major fiscal issues that is independent, unbiased, and easy to understand.
Join Our Mailing ListRead the latest report: A Year or More: The High Cost of Long-Term Unemployment - 2012 Update
The challenges facing the global economy are daunting and prompt a host of high-stakes discussions about appropriate policy responses. In the United States, debates continue about the declining manufacturing sector, the impact of immigration on low-wage workers, the extent to which free-trade agreements are beneficial, the health and status of the American Dream, the long-term consequences of a weak U.S. dollar, and the effectiveness of the tax code in confronting these new dynamics. Policy makers are also considering the proper role for government in engaging in, and regulating markets, and the need for fiscal discipline in an increasingly constrained environment.
America's position in the global economy is fundamentally interconnected to the financial conditions and prospects of other countries. As evidenced by continuing volatility in world markets, the policy choices we make in the United States have profound effects on nations and people around the world.
Pew's economic policy group combines a belief in the importance of upward mobility and the power of the market economy, with an understanding offered over two centuries ago by Alexander Hamilton that the market "may be beneficially stimulated by prudent aids and encouragements on the part of the government." In this spirit, we promote policies and practices that strengthen and ensure the future competitiveness of the U.S. economy by cultivating new bipartisan coalitions, informing critical national debates and striving toward meaningful policy change.
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text:
Modify ↓
Ticket #246 (new defect)
Opened 21 months ago
scientific notation resolver bug
Reported by: | genericsoma@… | Owned by: | xi |
Priority: | normal | Component: | pyyaml |
Severity: | normal | Keywords: | scientific float resolve |
Cc: |
There is a problem with scientific notation for numbers without floating point and also without '+' or '-' after 'e'. They are resolved as strings instead of float.
>>> import yaml >>> yaml.load('2e5') '2e5'
Attached patch solves this problem by providing a more complex implicit float resolver.
See also: http://code.google.com/p/snakeyaml/issues/detail?id=130
Change History
Changed 21 months ago by genericsoma@…
- attachment PyYAML-3.10.patch added
resolver patch and test suite update for the ticket
Note: See
TracTickets for help on using


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Information contained on this page is provided by an independent third-party content provider. WorldNow and this Station make no warranties or representations in connection therewith. If you have any questions or comments about this page please contact email@example.com.
SOURCE San Diego State University College of Business Administration
SAN DIEGO, Feb. 5, 2014 /PRNewswire/ -- The College of Business Administration at San Diego State University (SDSU) and the Lavin Entrepreneurship Center announced today that the first in a series of four educational speaking events scheduled for 2014 kicked off on January 28 with a panel session titled "Economic Outlook: A San Diego Business Perspective."
The panel consisted of four local business leaders: George Hadjis, founder and CEO of Oggi's Pizza and Brewing Company; David Marino, executive vice president of Hughes Marino; Susan Salka, CEO, president and director of AMN Healthcare Systems Inc.; and Jerry Sanders, president and CEO of the San Diego Regional Chamber of Commerce. The session was moderated by Stuart Sorenson of one of the speaker series sponsors, Duane Morris, LLP.
"San Diego State University, the College of Business Administration and the Lavin Entrepreneurship Center are committed to a deep level of community engagement," said Dr. Gangaram Singh, interim dean of the College of Business Administration. "We are delighted to collaborate with Duane Morris LLP, Moss Adams LLP and City National Bank to bring this series to our community."
The college and the center have planned future events focused on topics relevant to the local business community which will be presented to the public on a quarterly basis.
About the College of Business Administration
With nearly 5,000 students, SDSU's College of Business Administration is one of the largest business schools in the U.S. For over 50 years, the College has produced some of the most successful and influential business leaders in the world. For more information, visit www.sdsu.edu/business.
About SDSU
San Diego State University is a major public research institution offering bachelor's degrees in 89 areas, master's degrees in 78 areas and doctorates in 21 areas. The university provides transformative experiences, both inside and outside of the classroom, for its 34,000 students. Students participate in research, international experiences, sustainability and entrepreneurship initiatives, and a broad range of student life and leadership opportunities. The university's rich campus life features opportunities for students to participate in, and engage with, the creative and performing arts, a Division I athletics program and the vibrant cultural life of the San Diego region. For more information, visit www.sdsu.edu.
About the Lavin Entrepreneurship Center
The Lavin Entrepreneurship Center at San Diego State University serves students, entrepreneurs and business leaders through its entrepreneurial curriculum, workshops, internships, resources and events. The mission of the center is to inspire entrepreneurship across the campus and enable students to develop the entrepreneurial competencies necessary to compete in the global economy visit http://lavincenter.sdsu.edu/.
Contact: The Lavin Entrepreneurial Center
SDSU College of Business Administration
(619) 594-2781
©2012 PR Newswire. All Rights Reserved.


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text:
Cascade Volcanoes > Mount Hood > Climber's Log
Mount Hood Climber's Log
[ Sign the Climber's Log ]
bellinghamclimber | Gorgeous Day Date Climbed: Jul 6, 2011 | |
Nice climb on a Tuesday, only 4 other parties on the mountain, summit to ourselves! | ||
Posted Jul 6, 2011 7:17 pm |
I like it on top | Southside Route Date Climbed: Jun 25, 2011 | |
Summited with best friends, Perry, Troy, and Stanislav for the 2011 Cops on Top Summit for Heroes event. We will never forget. Absolutely perfect weather. I had an incredible time. | ||
Posted Jul 3, 2011 1:04 pm |
MissH | Lost Rainier but Won Hood Date Climbed: Jul 1, 2011 | |
Summitted Hood after leaving Rainier a day early due to bad weather. Nice little bonus on that trip. Went up Old Chute. Smelly and crunchy - fantastic weather and views. Can't wait to do again and beat my time. | ||
Posted Jul 3, 2011 5:54 am |
kutsch | Fun | |
Fun | ||
Posted Jun 26, 2011 8:18 pm |
Bezoar Goat | Blue Skies Date Climbed: Jun 17, 2011 | |
Perfect blue skies with views of Ranier & St. Helens. A great experience for my first Cascade climb. | ||
Posted Jun 21, 2011 6:23 pm |
Grampahawk | awesome views Date Climbed: Jun 17, 2011 | |
A 1 am start assured that we'd beat the crowds up the Hogsback and Pearly Gates. The sun came up on a Crystal clear day with bright blue skys. The sulpher fumeroles started to make me nauseous but the wind shifted and spared me any real discomfort. Had a nice ice scramble near the top of the "gates" and we had the summit to ourselves with fantastic views of Rainier, St Helen's, Adams, Jefferson and more. I was able to do several glissades, totalling about 1200 feet of elevation loss on the way down, adding to the fun. Topping everything off, Ralph Lauren was doing a photo shoot for their 2012 winter clothing line so there were many beautiful models hanging around the lodge, the Bruins won the title, and we were successful in climbing Mt Baker also! | ||
Posted Jun 18, 2011 1:57 pm |
Brian C | Cascade Highpoints Date Climbed: Jun 10, 2011 | |
Drove out from CO to climb Hood and Rainier. Warmed up with Mt. Hood on June 10th and climbed a variation of the old chute. The clouds came down below the summit ridge and cleared as we summited. It was nice to have the place all to ourselves. The next day we drove to Mt. Rainier and started up the Emmons glacier. We planned on staying at Emmons Flats but ended up staying at Schurman due to a blizzard/whiteout. After all parties but one peaced out due to weather we stayed another day and summited on June 14th on a beautiful but windy day. What a trip! | ||
Posted Jun 16, 2011 11:47 am |
Swithich | So-So trip. Date Climbed: Jun 11, 2011 | |
Climbed via the Old Chute route due to the Hogsback being pretty far west (all but two groups used this route on the day we summitted). Went later in the day when snow was softer and footsteps were plentiful (no crampons...bring crampons). Overall, my buddy and myself got; our first state highpoint, badly sunburned, and learned a lesson about ascending on ice slops without crampons. | ||
Posted Jun 12, 2011 7:37 pm |
RhythmicMom | Just an easy hike | |
I can't remember what we did on Mt Hood but I'm sure we did not climb the mountain. I think we drove up to some higher elevation and did a trail around the mountain. Don't remember anything strenuous - but I do remember the beautiful photos and the amazing summer wild flowers! Should go back and climb the mountain! :) | ||
Posted Jun 1, 2011 6:11 pm |
Levi | First sucessful Hood solo Date Climbed: May 19, 2011 | |
Couldn't have asked for a better day! The mostly full moon made the Palmer much less monotonous. The boot track was good apart from the final push up the Old Chute. I failed to solo it last year, so this was a good one to get! | ||
Posted May 19, 2011 7:01 pm |
Guero | Hood Date Climbed: Jun 1, 2003 | |
Started out on Leuthold, but bad weather turned us back up standard route. Nice, but short day to the top. | ||
Posted May 16, 2011 4:27 pm |
mjp20k | South Side Date Climbed: Jul 1, 1998 | |
Standard route with two friends | ||
Posted May 15, 2011 9:52 pm |
mjp20k | Leuthold Couloir Date Climbed: Jun 2, 1994 | |
Three hours 45 minutes from base to summit | ||
Posted May 15, 2011 9:51 pm |
jackstraw0083 | Old Chute Variation Date Climbed: Jan 15, 2006 | |
Perfect day on Hood. Can't wait to get back there with skis. | ||
Posted May 5, 2011 2:31 pm |
Princess Buttercup | Standard Route Date Climbed: Apr 23, 2011 | |
Incredible day. Carried the skis up to below the Hogsback, but stashed them due to ice-snow mix that just wasn't fun skiing. Late start = solo summit, but bluebird skies and a nice boot track from all the early-risers made for a great day! Be back to play on another route for sure!! | ||
Posted Apr 25, 2011 11:53 pm |
Karl Helser | First of the season... Date Climbed: Apr 23, 2011 | |
Solo trip to the summit, first of the season. Perfect day for the climb. Very cold till I hit the summit where the sun was waiting... Left the truck at 2:40am, hit the summit at 8:10am, took my time back to the truck because the weather was soooooo nice. | ||
Posted Apr 25, 2011 7:36 pm |
Monopole | Great Weather Date Climbed: Mar 18, 2010 | |
Excellent climb up the South Side (up the ski trails from Timberline lodge, via Hogsback and the Pearly Gates). Clear, blue skies and winds in single digits. | ||
Posted Apr 4, 2011 11:55 pm |
Ilafan | Perfect Day! | |
Oh Hell no I didn't get to the top, but I don't care. Mt. Hood rules. It was July, and kids were snowboarding! I was in snow in July, and I was freezing my Minnesota ass off. Fabulous! Mt. Hood is so majestic and regal. The lodge was great, the views unbelievable, and the Pacific Ocean I waded in after the hike was splendid. Perfect! | ||
Posted Mar 8, 2011 8:03 pm |
weeds19 | Group Climb Date Climbed: May 29, 2003 | |
We climbed up from Timberline and camped on the mountain just above the ski lifts. A quick glissade down was a highlight of the day! | ||
Posted Feb 24, 2011 10:38 am |
brizza | Old Chute Date Climbed: Jul 3, 2010 | |
Climbed w/ Tim and Mike. Great day. | ||
Posted Feb 18, 2011 7:37 pm |


text:
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In this picture topless Denise Milani is nude and naked


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Published on Wed, Oct 15, 2008
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SPD hosts public safety fair
Sequim Police Department will hold a public safety fair from 10 a.m.-4 p.m. Saturday, Oct. 18, at the Guy Cole Convention Center in Carrie Blake Park on Blake Avenue in Sequim. In addition to public safety information, the fair will feature information on crime prevention, emergency preparedness and public health. A number of police, fire and emergency vehicles will be on hand for viewing. Thirty public service agencies will be represented. There will be door prizes and giveaways to the first 400 attendees.
Reinvigorating the Grange
for a new generation of farmers
Exploring how a new generation of small farmers and other community members with an interest in developing a more sustainable farm and food system might better connect through local Granges is the topic of an upcoming meeting in Sequim.
Sponsored by Washington State University Clallam County Extension and the Sequim Prairie Grange, the event titled "Recreating the 'Culture' in Agriculture" will be held from 10 a.m.-3 p.m. Sunday, Oct. 26, at the Sequim Prairie Grange, 290 Macleay Road in Sequim.
The guest speaker will be Michael Ableman, a farmer and the author of "Fields of Plenty: A Farmer's Journey in Search of Real Food and People Who Grow It" and "The Good Land."
Farmers and interested community members from neighboring counties are welcome to join in the discussion on a space-available basis.
There is no charge for the event, but space is limited and advance registration is required. To register, call WSU Clallam County Extension at 417-2279.
Well 101: Operations and
Maintenance of a Small Water System
Clallam County Environmental Health is offering a Well 101 class for operators of small Group B water systems and private well owners. Participants will learn how to inspect, maintain and protect their well water system and about testing the water quality. The class is 6-8 p.m. Thursday, Oct. 16, at the Dungeness River Audubon Center, 2151 W. Hendrickson Road, Sequim. The class is free and open to the public. No preregistration is required. Phone 417-2506.
Lions Club hosts Halloween party
Sequim Dungeness Valley Lion's Club hosts a Halloween party with free candy and apples starting at 5 p.m. Oct. 31 at McDonald's of Sequim, 107 S. Seventh Ave.
Young guests also receive coupons from McDonald's for food and may receive party prizes. Last year's party hosted about 550 guests.
For more information, call Art Kessler of
Sequim Lions at 683-7018.
WSP launches improved Web site
Washington State Patrol has launched a new and improved public Web site. The address remains www.wsp.wa.gov, but some of the pages have been relocated on the site. The new site has easier navigation and layout. It was designed in response to research about user needs, with special attention paid to the most-visited pages.
The improvements include a comprehensive A-Z index, updated Employment page, enhanced Missing Children and Most Wanted pages, as well as a new search feature on the WSP's Scale Certifications page.
For questions or assistance, contact the WSP Web master at email@example.com.
Family Planning
holds open meeting
Family Planning of Clallam County, a local United Way Agency, has its October board of directors meeting beginning at 5:30 p.m. Monday, Oct. 20, at 1106 E. First St., Port Angeles. The meeting is open to the public. Family Planning welcomes community members who are interested in the agency, its services/programs, future directions and those interested in serving on the board of directors. For more information, call Family Planning of Clallam County at 452-2954.
Clallam County Prayer Breakfast
Apollo 16 astronaut Charlie Duke will be the featured speaker at The 12th annual Clallam County Prayer Breakfast.
The breakfast will be held 6:30-8:30 a.m. Oct. 24 at Sequim Community Church, 950 N. Fifth Ave., Sequim.
Clallam County Prayer Breakfast provides a forum for local civic, business and community members to hear an evangelistic message from a prominent individual and the opportunity to pray for government leadership.
Advance ticket purchase is required.
More information is available from Ron Gray at 683-3761 or Chuck Brown at 452-3351.
The tax man cometh
The second-half taxes for 2008 are due by Friday, Oct. 31, 2008, according to Clallam County treasurer Judith A. Scott. There are several drop-off locations throughout the county. In Sequim, payment may be dropped off at the office in the Sequim Plaza at 1001 E. Washington St. Accessing all payment options is available at www.clallam.net under New Features or at www.officialpayment.com. Payment must be either in the office or postmarked by Oct. 31. Payments postmarked on or after Nov. 1 will considered late and subject to 1 percent delinquent interest based on the balance due. For further questions call the Treasurer's Office at 417-2344.
VFW Ladies host 'Rock-a-Thon'
District 14 Veterans of Foreign Wars Ladies Auxiliary hosts a "Rock-A-Thon" from 9 a.m.-3 p.m. Nov. 15 at auxiliary homes throughout the district,
Auxiliary members will rock in rocking chairs to raise money for the Voice of Democracy scholarship program.
District 14 auxiliaries are in Sequim, Port Angeles, Brinnon, Port Hadlock, Port Townsend and Forks.
Members of the auxiliaries are rocking for an hour at a time at each post home. The public is invited to pick up information on the scholarship programs, find out how to become a member and cheer on the "golden oldies" as they rock for a good cause.
For more information, call Betty Marshall, District 14 president, at 683-3049.
The Sequim Gazette
is located at 147 W. Washington Street in Sequim.
Business hours are Monday through Friday from 8:30 a.m. to 5:00 p.m.
, or toll free at 800-829-5810. FAX 360-683-6670.
For a complete company directory with contact information please click
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by PaperG
© 2009 Sequim Gazette. All rights reserved. 147 West Washington, Sequim, WA 98382 • 360.683.3311
Email the Webmaster


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Catalogue Number: 351-2783
Earn 27 Clubcard points
Sellers at Tesco are third party sellers we have invited to sell on Tesco direct. These are companies we've selected to provide you with a wider range of products to choose from in one place. They are a mixture of well-known high street retailers and specialist retailers who operate online. Plus, you earn Clubcard points on all seller orders.
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The delivery and return of seller items is managed by each seller. For further details, or if you have a question about the delivery or return of a seller product, please use the Seller directory to find the seller's 'help' page.
This readybed comes in a super cute Disney Princess themed design and combines an inflatable mattress with bedding and a pillow. The portable bed has a built-in cover that can easily be removed for washing. The readybed also comes with a pump as well as a carry case that is integral to the bed for easy transportation. The bed is machine washable. Age range 3 years+.
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Find inspiration, tips and gardening techniques for cacti.
A link to %this page% was e-mailed
Visit HGTVGardens for expert tips on growing these versatile, low-maintenance plants indoors and out.
Landscaping 101: Learn the Different Plant Groups (13 photos)
Dress Up Houseplants With Bold Planters (15 photos)
11 Succulents for a Desert Garden (11 photos)
Yee-haw! Turn a container into a desert landscape by filling it with prickly cacti and other succulent plants.
Hoodia is rare because it's difficult to cultivate. It prefers very high temperatures, sandy soil and almost no water.
The whole succulent world has a monstrous side that the uninitiated rarely see. But for the succulent plant junkie, the cactus is the m...
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text: Home » Jandd Mountain 4 Handlebar Bag: Black Click Image To Enlarge Jandd Mountain 4 Handlebar Bag: Black Our Price: $72.95 Add To Cart Wishlist Rate This Product Description The Mountain Handle Pack Series is perfect for keeping all the essentails, from maps and journals to binoculars and snacks, all within instant reach. Mounts with quick-release bracket (QRB), fits clamp sizes of 25.4 and 26.0. For 31.8 fit some material on the bracket must be removed with a dremel tool. Call Jandd for instructionFoldaway map compartment3M reflective trimD-rings for an optional shoulder strapMade with durable Dupont Cordura Item SpecificationsColorBlackTotal Volume334in3Weight650gDimensions7.5 x 9.5 x 3.25"Defined ColorBlack You May Also Like Customer Reviews Be the first one to review this product!


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Our current best practice for making SNP and indel calls is divided into four sequential steps: initial mapping, refinement of the initial reads, multi-sample indel and SNP calling, and finally variant quality score recalibration. These steps are the same for targeted resequencing, whole exomes, deep whole genomes, and low-pass whole genomes.
Example commands for each tool are available on the individual tool's wiki entry. There is also a list of which resource files to use with which tool.
Note that due to the specific attributes of a project the specific values used in each of the commands may need to be selected/modified by the analyst. Care should be taken by the analyst running our tools to understand what each parameter does and to evaluate which value best fits the data and project design.
There are four major organizational units for next-generation DNA sequencing processes that used throughout this documentation:
This document describes how to call variation within a single analysis cohort, comprised for one or many samples, each of one or many libraries that were sequenced on at least one lane of an NGS machine.
Note that many GATK commands can be run at the lane level, but will give better results seeing all of the data for a single sample, or even all of the data for all samples. Unfortunately, there's a trade-off in computational cost by running these commands across all of your data simultaneously.
In order to help individuals get up to speed, evaluate their command lines, and generally become familiar with the GATK tools we recommend you download the raw and realigned, recalibrated NA12878 test data from the GATK resource bundle. It should be possible to apply all of the approaches outlined below to get excellent results for realignment, recalibration, SNP calling, indel calling, filtering, and variant quality score recalibration using this data.
In our GATK 2.0 slide archive.
The GATK data processing pipeline assumes that one of the many NGS read aligners (see this review) has been applied to your raw FASTQ files. For Illumina data we recommend BWA because it is accurate, fast, well-supported, open-source, and emits SAM files natively (which are then easy to convert to BAM).
The three key processes used here are:
There are several options here from the easy and fast basic protocol to the more comprehensive but computationally expensive pipeline. For example, there are two types of realignment which constitute a vastly different amount of processing power required:
This protocol uses lane-level local realignment around known indels (very fast, as there's no sample level processing) to clean up lane-level alignments. This results in better quality scores, as they are less biased for indel alignment artefacts.
for each lane.bam dedup.bam <- MarkDuplicate(lane.bam) realigned.bam <- realign(dedup.bam) [at only known sites, if possible, otherwise skip] recal.bam <- recal(realigned.bam)
Here we are essentially just merging the recalibrated lane.bams for a sample, dedupping the reads, and calling it quite. It doesn't perform indel realignment across lanes, so it leaves in some indels artifacts. For humans, which now have an extensive list of indels (get them from the GATK bundle!) the lane-level realignment around known indels is going to make up for the lack of cross-lane realignment. This protocol is appropriate if you are going to use callers like the HaplotypeCaller, UnifiedGenotyper with BAQ, or samtools with BAQ that are less sensitive to the initial alignment of reads, or if your project has limited coverage per sample (< 8x) where per-sample indel realignment isn't more empowered than per-lane realignment. For other situations or for organisms with limited database of segregating indels, it's better to use the advanced protocol if you have deep enough data per sample.
for each sample recals.bam <- merged lane-level recal.bams for sample dedup.bam <- MarkDuplicates(recals.bam) sample.bam <- dedup.bam
As with the basic protocol, this protocol assumes the per-lane processing has been already completed. This protocol is essentially the basic protocol but with per-sample indel realignment.
for each sample recals.bam <- merged lane-level recal.bams for sample dedup.bam <- MarkDuplicates(recals.bam) realigned.bam <- realign(dedup.bam) [with known sites included if available] sample.bam <- realigned.bam
This is the protocol we use at the Broad in our fully automated pipeline because it gives an optimal balance of performance, accuracy and convenience.
Rather than doing the lane level cleaning and recalibration, this process aggregates all of the reads for each sample and then does a full dedupping, realign, and recalibration, yielding the best single-sample results. The big change here is sample-level cleaning followed by recalibration, giving you the most accurate quality scores possible for a single sample.
for each sample lanes.bam <- merged lane.bams for sample dedup.bam <- MarkDuplicates(lanes.bam) realigned.bam <- realign(dedup.bam) [with known sites included if available] recal.bam <- recal(realigned.bam) sample.bam <- recal.bam
This protocol can be hard to implement in practice unless you can afford to wait until all of the data is available to do data processing for your samples.
ReduceReads is a novel (perhaps even breakthrough?) GATK 2.0 data compression algorithm. The purpose of ReducedReads is to take a BAM file with NGS data and reduce it down to just the information necessary to make accurate SNP and indel calls, as well as genotype reference sites (hard to achieve) using GATK tools like UnifiedGenotyper or HaplotypeCaller. ReduceReads accepts as an input a BAM file and produces a valid BAM file (it works in IGV!) but with a few extra tags that the GATK can use to make accurate calls.
You can find more information about reduced reads in some of our presentations in the archive.
ReduceReads works well for exomes or high-coverage (at least 20x average coverage) whole genome BAM files. In this case we highly recommend using ReduceReads to minimize the file sizes. Note that ReduceReads performs a lossy compression of the sequencing data that works well with the downstream GATK tools, but may not be supported by external tools. Also, we recommend that you archive your original BAM file, or at least a copy of your original FASTQs, as ReduceReads is highly lossy and doesn't quality as an archive data compression format.
Using ReduceReads on your BAM files will cut down the sizes to approximately 1/100 of their original sizes, allowing the GATK to process tens of thousands of samples simultaneously without excessive IO and processing burdens. Even for single samples ReduceReads cuts the memory requirements, IO burden, and CPU costs of downstream tools significantly (10x or more) and so we recommend you preprocess analysis-ready BAM files with ReducedReads.
for each sample sample.reduced.bam <- ReduceReads(sample.bam)
After the raw data processing step, the GATK variant detection process assumes that you have aligned, duplicate marked, and recalibrated BAM files for all of the samples in your cohort. Because the GATK can dynamically merge BAM files, it isn't critical to have merged files by lane into sample bams, or even samples bams into cohort bams. In general we try to create sample level bams for deep data sets (deep WG or exomes) and merged cohort files by chromosome for WG low-pass.
For this part of the this document, I'm going to assume that you have a single realigned, recalibrated, dedupped BAM per sample, called sampleX.bam, for X from 1 to N samples in your cohort. Note that some of the data processing steps, such as multiple sample local realignment, will merge BAMS for many samples into a single BAM. If you've gone down this route, you just need to modify the GATK commands as necessary to take not multiple BAMs, one for each sample, but a single BAM for all samples.
The next step in the standard GATK data processing pipeline, whole genome or targeted, deep or shallow, is to apply the Haplotype Caller or Unified Genotyper to identify sites among the cohort samples that are statistically non-reference. This will produce a multi-sample VCF file, with sites discovered across samples and genotypes assigned to each sample in the cohort. It's in this stage that we use the meta-data in the BAM files extensively -- read groups for reads, with samples, platforms, etc -- to enable us to do the multi-sample merging and genotyping correctly. It was a pain for data processing, yes, but now life is easy for downstream calling and analysis.
A common question is the confidence score threshold to use for variant detection. We recommend:
raw.vcf <- HaplotypeCaller(sample1.bam, sample2.bam, ..., sampleN.bam)
raw.vcf <- UnifiedGenotyper(sample1.bam, sample2.bam, ..., sampleN.bam)
option. However you can use Queue to parallelize execution of HaplotypeCaller.This raw VCF file should be as sensitive to variation as you'll get without imputation. At this stage, you can assess things like sensitivity to known variant sites or genotype chip concordance. The problem is that the raw VCF will have many sites that aren't really genetic variants but are machine artifacts that make the site statistically non-reference. All of the subsequent steps are designed to separate out the false positive machine artifacts from the true positive genetic variants.
The process used here is the Variant quality score recalibrator which builds an adaptive error model using known variant sites and then applies this model to estimate the probability that each variant in the callset is a true genetic variant or a machine/alignment artifact. All filtering criteria are learned from the data itself.
Take a look at our FAQ page for specific recommendations on which training sets and command-line arguments to use with various project designs. It is expected that analysis will be required by the user when determining the best way to use this tool for different projects. These recommendations are only meant as jumping off points!
We've found that the best results are obtained with the VQSR when it is used to build separate adaptive error models for SNPs versus INDELs:
snp.model <- BuildErrorModelWithVQSR(raw.vcf, SNP) indel.model <- BuildErrorModelWithVQSR(raw.vcf, INDEL) recalibratedSNPs.rawIndels.vcf <- ApplyRecalibration(raw.vcf, snp.model, SNP) analysisReady.vcf <- ApplyRecalibration(recalibratedSNPs.rawIndels.vcf, indel.model, INDEL)
In our testing we've found that in order to achieve the best exome results one needs to use an exome callset with at least 30 samples. Also, for experiments that employ targeted resequencing of a small region (for example, a few hundred genes), VQSR may not be empowered regardless of the number of samples in the experiment. For users with experiments containing fewer exome samples or with a small target region there are several options to explore (listed in priority order of what we think will give the best results):
--maxGaussians 4 --percentBad 0.05
to your command line. Note that this is very dependent on your dataset, and you may need to try some very different settings. It may even not work at all. Unfortunately we cannot give you any specific advice, so please do not post questions on the forum asking for help finding the right parameters. These recommended arguments for VariantFiltration are only to used when ALL other options are not available:
You will need to compose filter expressions (see here, here and here for details) to filter on the following annotations and values:
For SNPs:
HaplotypeScore > 13.0
MQRankSum < -12.5
ReadPosRankSum < -8.0
For indels:
ReadPosRankSum < -20.0
InbreedingCoeff < -0.8
Note that the InbreedingCoeff statistic is a population-level calculation that is only available with 10 or more samples. If you have fewer samples you will need to omit that particular filter statement.
For shallow-coverage (<10x): you cannot use filtering to reliably separate true positives from false positives. You must use the protocol involving variant quality score recalibration.
The maximum DP (depth) filter only applies to whole genome data, where the probability of a site having exactly N reads given an average coverage of M is a well-behaved function. First principles suggest this should be a binomial sampling but in practice it is more a Gaussian distribution. Regardless, the DP threshold should be set a 5 or 6 sigma from the mean coverage across all samples, so that the DP > X threshold eliminates sites with excessive coverage caused by alignment artifacts. Note that for exomes, a straight DP filter shouldn't be used because the relationship between misalignments and depth isn't clear for capture data.
That said, all of the caveats about determining the right parameters, etc, are annoying and are largely eliminated by variant quality score recalibration.


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MFB thanks those promoting ag, at Annual Meeting awards
By SHELLY STRAUTZ-SPRINGBORN
Michigan Correspondent
GRAND RAPIDS, Mich. — Frank Rochowiak has been telling the story of agriculture for most of the 55 years he has been a member of Michigan Farm Bureau (MFB).
Rochowiak was one of five recipients of awards recognizing volunteers and media representatives for efforts in promoting and informing the public on agriculture, during the annual Promotion and Education Committee Luncheon Nov. 29 at Michigan Farm Bureau's 93rd Annual Meeting.
MFB presented him with its 2012 Agricultural Promoter of the Year Award. Alcona High School teacher Brian Matchett earned the organization's Agricultural Educator of the Year Award.
Former Heritage Newspapers reporter Tanya Wildt and the WZZM TV-13 news team, led by News and Information Director Stanton Tang, were named the MFB Agricultural Communicators of the Year, and freelance writer Cindy Crain Newman earned an honorable mention in the contest.
Rochowiak was recognized for a lifetime spent bridging the gap between farmers and consumers. "Frank is a voice for all farmers – grain, livestock, vegetables and retailers," said Colette McClinton, president of the Wayne County Farm Bureau."
He has been active with the local FFA chapter, 4-H youth program, Michigan State University extension and the Wayne County Fair Board.
"I love getting out into the community and promoting where our food comes from," Rochowiak said. "I've been a Farm Bureau member for 55 years and promote agriculture wherever I go."
Fair Board member Mary Zellner said Rochowiak "is not afraid to get his hands dirty. Once you determine a project, he's right there to help."
The award includes a $500 grant for future promotional efforts. Rochowiak was nominated by the Wayne County Farm Bureau and chosen by the MFB State Promotion and Education Committee, from 15 nominations submitted from across the state.
Matchett was recognized for his achievements in agriscience education. He has connected his FFA students to the Alcona County community and has grown the agriscience program more than 300 percent during the past nine years. His students develop critical thinking skills through hands-on projects such as turning sap into maple syrup in the school's sugar shack, operating a greenhouse and making biodiesel from recycled vegetable oil collected from local restaurants.
Huron Shores Farm Bureau Board Member Stephenye Boyat said "his curriculum is project-based and hands-on, which helps students learn agricultural concepts and apply them.
"Brian is such a go-getter. He gets kids excited about agriculture," she said.
Matchett said he feels "fortunate to go to school every day to teach students about agriculture. There's nothing more rewarding than seeing students make a connection between a science concept and agricultural production."
The award includes a $500 grant from the MFB Member Services Department to benefit his classroom projects.
Nominated by Washtenaw County Farm Bureau, Wildt was selected for her extensive coverage of ag news and issues in southeastern Michigan. In addition to printed articles, Wildt covered ag on nearly a daily basis through her blog, "Harvesting Washtenaw."
She said after taking over the farm beat in late 2011, she met with Wayne County Farm Bureau member Kathy Siler, who shared farmer contacts and many story ideas. "This award is as much hers as mine," Wildt said of Siler. "I've seen the passion the agricultural community has for its craft and I've developed a deep appreciation for the industry."
Siler said Wildt quickly established herself as a premier ag reporter. "She dedicated herself to learning about agriculture and covering agricultural issues," she said. "The depth and breadth of agricultural coverage in Washtenaw County increased exponentially because of Tanya."
The WZZM TV-13 news team was nominated by the Kent County Farm Bureau for its track record of sound agricultural reporting and in-depth coverage of issues affecting local communities.
During the past year, the team has covered stories about the effects of adverse weather on various farm commodities, agricultural technology and careers, the farm bill and county Farm Bureau events and programs. "The staff at WZZM has reached out to Kent County Farm Bureau to ensure factual and accurate reporting," said Annie Link, who nominated the news team for the award. "It's impressive to see the depth of the stories covered and how professional their team has been.
"They do a fair job. They don't do a biased story, and we appreciate that," added Merle Langeland of the Ottawa County Farm Bureau.
Tang, the team's director, said it strives "to tell honest stories about our communities … agriculture is a large part of that."
With more than 30 years of experience writing for newspapers, magazines and corporate publications, Newman said her favorite interviews are with farmers. "Nothing makes me happier than to be invited into the cow barn or into the combine cab," she said. "I've had some lovely experiences."
Nominated by the Midland County Farm Bureau, Newman is a contributing writer for Michigan Blue and Great Lakes Bay magazines, as well as the Midland Daily News.
"It is a real testament to Cindy's talents that she can write about such complex processes in agriculture and make them interesting enough to keep the community engaged," said Tricia Steele, who nominated Newman. "Cindy gets out into the fields without hesitation. She gives the reader the whole story and shows how the work gets done."
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Saturday, November 26, 2005
The Valparaiso University volleyball closed out the regular season Saturday night, falling 3-0 to Marquette at the MU Battle for the Bird in Milwaukee, Wis. The Crusaders season is not over, however, and they will find out who their first round NCAA Tournament opponent will be Sunday at 1:30 p.m.Copyright ©2014 Valparaiso University Athletics. All Rights Reserved. | www.ValpoAthletics.com |


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Address: Jiron Recoleta s/n Urubamba, Cusco - Peru.
"Wonderful Experience"
This beautiful old monastery hotel was nice and quiet and we slept very well. It is a 10-15 minute walk into Urubamba. Our room was comfortable. Their breakfast buffet was extensive, they had a toaster available and served over easy eggs. Good selection of breads and fruits. I would have enjoyed spending more time at this hote lbut we were with Gate1 Travel and were only here for two nights.
"A peaceful place"
We stayed in this hotel after spending a couple of days in Machu Picchu. It is a beautiful old monastery that sits within the mountains. It has impeccable gardens and the rooms were great. We were here for two nights and it was a great/peaceful place to rest. The onsite restaurant was wonderful offering many local flavors. The breakfast is also very well stocked.
"Wishing to be back one day..."
Many travellers to the Sacred Valley of Peru are probably here for the same reason I was - to visit and learn about the sacred sites of Peru. This converted Monastry to Boutique hotel was a perfect resting place after a long day of travel. Not only rustic, elegant and beautiful, but the rooms are "restful" with bedding that is very comfortable. The property has many wonderful private spots around the courtyard and grounds, perfect for journaling or just connecting with yourself.


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Moser Engineering truly values your business and wishes to make your online experience a positive one. If you have any suggestions or questions or just wish to drop us an email then please follow one of our 3 choices below that best suit your needs. For common questions please look thru our FAQ section to see if your question has already been addressed. If you need more immediate assistance then fill in the contact section below along with your question and we will respond or call if you prefer and leave a number. Our salesman will respond Mon-Fri from 8-5 Eastern time.
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- 260-726-6689
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Peter Jones
Take a look at Peter Jones' fashion floors. If you can't choose from all of the fabulous famous fashion brands, ask the Fashion Advisor for a free consultation to help you achieve the look you want. Complete your look with stunning shoes, jewellery and handbags. Then enjoy expert pampering in the relaxing beauty rooms and shop for all your favourite cosmetics and perfumes in the stunning beauty department. You'll find exclusively designed souvenirs in the gift shop and stunning homewares as well as the latest technology, including digital cameras, MP3 players and gaming. Don't forget to visit the Top Floor restaurant, with its spectacular views over London. Open 7 days a week.
This content has been supplied by Peter Jones
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Peter Jones
- Address
Sloane SquareChelseaLondonSW1W 8EG
- Telephone:
- 0844 6931751
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- http://www.johnlewis.com/our-shops/peter-jones
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- Sloane Square
Going to Peter Jones using public transport? Find the fastest route:
Excellent department store, with John Lewis quality of service throughout. Watch out for the static electricity on the escalators though.more
Basically John Lewis but probably called Peter Jones as it's in Sloane Square so prepare to bump shoulders with lots of Made in Chelsea / Sloane Ranger wannabes and tourists.
I'd been here before years ago but never to the restaurant / cafe at the top. My friend and I visited it today after an unsuccessful trip to the nearby Chelsea Physic Gardens (they were closed!) and we were starving and...more
Yep, it's just like John Lewis. Exactly the same! I mean, down to the font and colour of the logo lettering. To me, this doesn't mean so much. It's still a lot of overpriced crap. They run out of things often--they were out of Christmas decorations a week before Christmas with no intent of stocking more. And the salespeople act like it was a toss up between a root canal or coming to work that...more
I know this place holds some kind of reverence for Sloaney wannabees and I'm-in-London-for-the-day-dahling scenesters, but in reality, it's just a John Lewis isn't it.
A huge one at that. So if you know what you want and you're willing to pay John Lewis prices to get it, Peter Jones is ideal. Provided you live in the area that is. Otherwise you'd might as well go somewhere more local...more
A Chelsea institution. This stylish small-ish department store sells a little bit of everything. Their kitchen department is fabulous to find basics home items with a little bit of flair.more


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Herbed Tomato and Potato Salad
Comment on this recipe
8 small red potatoes (about a pound) 1/2 cup chopped fresh or 3 tablespoons dried basil leaves 1/3 cup chopped fresh or 2 tablespoons dried sage leaves 1/3 cup chopped fresh or 2 tablespoons dried mint leaves 1/2 cup olive or vegetable oil 1/2 cup wine vinegar 5 Roma (plum) tomatoes, cut into fourths 1 small onion, finely chopped (1/4 cup)
Heat 1 inch water (salted if desired) to boiling in 3-quart saucepan. Add potatoes. Cover and heat to boiling; reduce heat. Cook 20 to 25 minutes covered until tender; drain and cool. Peel potatoes; cut into 1/2 inch slices. Gently mix potatoes and remaining ingredients. Cover and refrigerate about 2 hours, stirring occasionally, until chilled. Serves 6.
Jolene Harvey Davenport
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Find Ancestors
Welcome to the Genes Reunited community boards!
- The Genes Reunited community is made up of millions of people with similar interests. Discover your family history and make life long friends along the way.
- You will find a close knit but welcoming group of keen genealogists all prepared to offer advice and help to new members.
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- The Genes community will go out of their way to help you, so don't be shy about asking for help.
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Read about historical events at the time they were happening. Perhaps you'll discover your ancestor in their local newspaper?
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Profile | Posted by | Options | Post Date |
Frances | Report | 9 Feb 2013 13:54 |
David Thomas Jones (born 1888), went to the States. |
Margee | Report | 9 Feb 2013 14:49 |
Wouldn't it have been better to add this to your thread earlier this week? Where is that thread? You didn't delete it, did you? |
Researching: |
Frances | Report | 9 Feb 2013 15:19 |
My thread died and I couldn't get any more responses. Then yesterday and today I have had more information which means that the earlier thread was inaccurate-particularly as to the name of the person I was looking for. I am quite happy to add this to that but I had the feeling that no-one was able to help further on the question I asked there. |
MarieCeleste | Report | 9 Feb 2013 15:46 |
Frances, it helps us greatly if everything is on one thread. If there's anything that's inaccurate it just needs to be noted. Otherwise, if you start again then that same inaccurate info could just get dredged up again. |
Researching: |
Frances | Report | 9 Feb 2013 16:07 |
O. K-. the inaccuracies were mine- the name was wrong but I will . Thank you. |
mgnv | Report | 10 Feb 2013 00:45 |
I'll post on old thread: |


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My serial Number and Product Key are not accepted when input during th einstallation process. How can I get this resolved? You have to have the product regestered in order to get to Customer Support - and you can't register without the software accpeting the serial number and produce key.
Solved! Go to Solution.
Hello William and welcome to the community!
Can you verify that the name at the top of the software installation / activation screen says AutoCAD LT and not AutoCAD, which is one of the common causes of an invalid Serial Number or Product Key error.
If that is the case, you can download the correct program from our trials page.
Please accept as a solution if this fully resolves the issue, or reply with additional specifics if the problem persists.
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Our toolkit helps cities, events, and organizations reduce single occupancy vehicle rates and encourage smarter travel, providing people with the tools to travel within the community, not through it. Learn more >>
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The typedef statement allows the programmer to create an alias, or synonym, for an existing data type. This can be useful in documenting a program. The C++ programming language syntax is:
typedef <the real data type> <the alias identifier name>;
Let's say a programmer is using a double data type to store the amount of money that is being used for various purposes in a program. He might define the variables as follows:
Example 1: Regular Definition of Variables
double income;
double rent;
double vacation;
However, he might use the typedef statement and define the variables as follows:
Example 2: Using typedef when Defining Variables
typedef double cash;
the typedef must be defined before its use
cash income;
cash rent;
cash vacation;
The typedef statement is not used very often by beginning programmers. It usually creates more confusion than needed, thus stick to using the normal data types at first.


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UPDATE 2-Gentiva buys private home health business to cut Medicare dependence
* To acquire Harden businesses for about $409 mln
* To buy Harden's home health, hospice, community care businesses
* Gentiva expects 2014 combined revenue of $2.1-$2.2 bln
* Gentiva shares rise as much as 11 pct
Sept 19 (Reuters) - Gentiva Health Services Inc will buy the home health, hospice and community care businesses of privately held Harden Healthcare Services for about $409 million to expand its patient base in the face of continued Medicare reimbursement cuts.
Gentiva shares rose as much as 11 percent on the Nasdaq.
The deal will help expand Gentiva's services to so-called dual-eligibles - people who qualify for both the elderly and disabled-focused Medicare insurance plan and for Medicaid, which covers the poor.
Dual-eligible patients include those who have trouble carrying out daily activities such as bathing or dressing. They are reimbursed first by Medicare and then by Medicaid.
CRT Capital analyst Sheryl Skolnick said the dual-eligible population would be a richer source of reimbursement for Gentiva than its home health or hospice businesses, which are mostly reimbursed by Medicare.
"Typically, Medicaid will pay for personal care in some limited way, but for the duals, they pay for it a lot," she said.
Gentiva also said that the deal will help reduce its dependence on revenue from Medicare, which contributed about 86 percent of the company's revenue in 2012.
The home healthcare provider has been struggling with the budget cuts and changes in Medicare reimbursement rates brought on by President Barack Obama's healthcare law.
Given that these rate pressures are likely to continue, synergies from the deal could help offset future cuts, Gentiva Chief Executive Tony Strange said.
Gentiva said it expects the deal to add to adjusted earnings per share within 12 months of its close in the fourth quarter.
The combined company is expected to record revenue of between $2.1 billion and $2.2 billion in 2014. Half of that is expected to come from home health, 41 percent from hospice and 10 percent from community care, which includes dual-eligible patients.
Gentiva will pay Harden shareholders $355 million in cash and the rest in common stock.
Harden's shareholders will retain the company's long-term care business, which includes 49 skilled nursing and assisted living facilities in Texas.
Gentiva will fund the cash portion of the deal through available cash and a new credit facility.
It expects to obtain a term loan facility of $855 million to finance the deal and refinance its existing term loans.
Barclays and BofA Merrill Lynch provided committed financing for the deal, Gentiva said.
Edge Healthcare Partners LLC was the financial adviser to Gentiva, while Harden was advised by Barclays.
Greenberg Traurig LLP was legal counsel to Gentiva, while Alston & Bird LLP was Harden's legal adviser.
Gentiva shares were up 10 percent at $12.22 in early-afternoon trading.