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Posted: Feb 25, 2014 4:00 PM
Updated: Feb 26, 2014 4:01 AM
Obama threatens Karzai with full US troop withdrawal from Afghanistan by end of year
WASHINGTON (AP) Frustrated with his Afghan counterpart, President Barack Obama is ordering the Pentagon to accelerate planning for a full U.S. troop withdrawal from Afghanistan by the end of this year. But Obama is also holding out hope that Afghanistan's next president may eventually sign a stalled security agreement that could prevent the U.S. from having to take that step.
Obama spoke Tuesday with Afghan President Hamid Karzai, the first direct conversation between the two leaders since last June. The White House has become increasingly frustrated with Karzai, who has refused to sign a security pact that the White House says is crucial to keeping a U.S. troop presence in Afghanistan after the war formally concludes at the end of this year.
With no sign that Karzai will sign the agreement, White House spokesman Jay Carney said Obama "has tasked the Pentagon with preparing for the contingency that there will be no troops in Afghanistan beyond 2014." However, he added that the U.S. remains open to keeping troops in Afghanistan if an agreement can be signed later this year, likely after the April Afghan elections.
That decision appeared aimed at marginalizing Karzai's role in the high-stakes negotiations over the future of the lengthy American-led war. The Afghan leader has deeply irritated Washington with anti-American rhetoric, as well as with his decision this month to release 65 prisoners over the objections of U.S. officials.
The White House insists it won't keep any American troops in Afghanistan after December without a security agreement giving the military a legal basis for staying in the country. While the White House did not publicly set a deadline for finalizing the agreement before that time, officials said the size and scope of any U.S. mission could shrink the longer Obama waits.
Ukraine disbands feared riot police unit blamed for violent attacks on protesters
KIEV, Ukraine (AP) Ukraine's acting interior minister on Wednesday ordered the disbandment of a feared riot police force that many accuse of attacks on protesters during the country's three-month political turmoil.
Arsen Avakov wrote on his Facebook page that he has signed a decree to disband the force known as Berkut and said more detail would be announced later.
Anti-government protesters have blamed Berkut for violent attacks against peaceful demonstrators protesting authorities' decision to ditch closer ties with the European Union and turn to Moscow instead. Those attacks galvanized long-brewing anger against police and the protests quickly grew into a massive movement, attracting crowds exceeding 100,000 and establishing an extensive tent camp in the capital's main downtown square.
The force, whose name means "golden eagle," consisted of about 5,000 officers. It was unclear Wednesday if its members would be dismissed or if they would be reassigned to other units.
President Viktor Yanukovych and protest leaders signed an agreement last week to end the conflict that left more than 80 people dead in just a few days in Kiev. Shortly after, Yanukovych fled the capital for his powerbase in eastern Ukraine but his exact whereabouts are unknown.
Cartel leader's high-tech gadgets, counterspy tactics helped him evade capture for 13 years
WASHINGTON (AP) Mexico's most powerful drug cartel leader employed high-tech communications gadgetry and sophisticated counterespionage practices to elude an international manhunt for 13 years, The Associated Press has learned. In the end, however, life on the run unraveled for Joaquin "El Chapo" Guzman in a decidedly low-tech way.
A traditional wiretap in southern Arizona pointed authorities to a cellphone being used by a top associate. Within a day, Guzman was captured in a high-rise beachfront condominium in Mazatlan, Mexico.
Guzman's penchant for technology and his efforts to stay ahead of the law were described to the AP by a senior law enforcement official with direct knowledge of Guzman's years on the run and by a U.S. government official who was briefed on the case. Both spoke only on condition of anonymity because they were not authorized to discuss the situation by name.
"He didn't spare any expenses when it came to protecting himself," the law enforcement official said.
Some of the communications equipment Guzman used was not generally available to consumers. The sophistication of the gear and Guzman's diligence deeply impressed investigators who were pursuing him. Among other practices, Guzman employed countersurveillance scanners to detect transmitters hidden in rooms or carried by people with whom he was meeting.
Government study says preschooler obesity fell sharply; experts wary of declaring victory
ATLANTA (AP) Toddler obesity shrank sharply in the past decade, a new study suggests. While promising, it's not proof that the nation has turned a corner in the battle against childhood obesity, some experts say.
The finding comes from a government study considered a gold-standard gauge of trends in the public's health. The researchers found that obesity among children ages 2 to 5 decreased to 8 percent, from 14 percent a decade ago. That would represent a 43 percent drop.
But the only decline was seen in preschoolers, not in older children. And some experts note that even the improvement in toddlers wasn't a steady decline, and say it's hard to know yet whether preschooler weight figures are permanently curving down or merely jumping around.
It is enough of a decline to be optimistic, said Cynthia Ogden, one of the study's authors.
"There's a glimmer of hope," said Ogden, an epidemiologist with the Centers for Disease Control and Prevention.
Avalanche deaths spike as storms dump snow, fuel dangerous conditions across West
SEATTLE (AP) Skiers and snowboarders rejoiced when a series of storms dumped several feet of snow in the mountains across the West, after what had been a disappointing start for those seeking fresh powder in the backcountry.
But all the new snow and strong winds in the past month have fueled dangerous conditions from the Cascades to the Rockies, prompting forecasters to issue warnings of considerable or high avalanche danger for many places outside of established ski areas.
Seventeen people have died in an avalanche this winter, 11 of them since early February. Many more skirted disaster and survived with broken bones or other injuries. Some were partially buried in snow, but managed to dig themselves out or were dug out by companions.
Avalanche experts are seeing a similar problem across the region: too much snow and strong winds overloading weak layers of old snow. With too much stress and not enough time to bond or stabilize, that weak snow layer eventually gives way.
"It's like putting a brick on top of a pile of potato chips," said Bruce Tremper, director of the U.S. Forest Service's Utah Avalanche Center.
Tale of two messages? NYC mayor's inequality fight sidelined by slew of 'sideshows'
NEW YORK (AP) New York City Mayor Bill de Blasio's ambitious agenda to fight income inequality a campaign he famously titled "The Tale of Two Cities" has taken a backseat in recent weeks to a series of political stumbles that have become tabloid fodder and shaken his everyman image.
First, there was his late-night call to police on behalf of a political ally who was arrested but didn't spend a night in jail. ("BAIL OF TWO CITIES: Blaz's call to cops springs pal," the Daily News blared.)
Then came widespread second-guessing led by TV weatherman Al Roker over inconsistent snowplowing of the tony Upper East Side in one heavy storm and the decision to keep schools open in another ("LET THEM EAT SNOW!: Rage as Bill keeps schools open," the New York Post chided.)
And most recently, a TV news video caught de Blasio's motorcade speeding through stop signs, two days after he introduced a sweeping traffic safety program. ("It's another tale of two cities," the Daily News wrote, "one set of traffic rules for Mayor de Blasio, and one for the rest of us.")
The mayor has often responded by being defensive and snippy when dealing with the media, and then chastising reporters for focusing on the blunders.
Samsung's fingerprint technology not bulletproof, but provides convenient security
BARCELONA, Spain (AP) Samsung's upcoming Galaxy S5 smartphone will be at least the third to have a fingerprint sensor for security but it's alone in letting you use that for general shopping, thanks to a partnership with PayPal.
The sensor brings convenience for entering passcodes and could encourage more people to lock their phones. But fingerprint security isn't foolproof.
Here's what to know as you consider whether to place your trust in it:
How does it work?
Tiny houses employed to help tackle big homeless problem nationwide
MADISON, Wis. (AP) While tiny houses have been attractive for those wanting to downsize or simplify their lives for financial or environmental reasons, there's another population benefiting from the small-dwelling movement: the homeless.
There's a growing effort across the nation from advocates and religious groups to build these compact buildings because they are cheaper than a traditional large-scale shelter, help the recipients socially because they are built in communal settings and are environmentally friendly due to their size.
"You're out of the elements, you've got your own bed, you've got your own place to call your own," said Harold "Hap" Morgan, who is without a permanent home in Madison. "It gives you a little bit of self-pride: This is my own house."
He's in line for a 99-square-foot house built through the nonprofit Occupy Madison Build, or OM Build, run by former organizers with the Occupy movement. The group hopes to create a cluster of tiny houses like those in Olympia, Wash., and Eugene and Portland, Ore.
Many have been built with donated materials and volunteer labor, sometimes from the people who will live in them. Most require residents to behave appropriately, avoid drugs and alcohol and help maintain the properties.
California couple uncover rare gold coins worth $10 million while walking their dog
LOS ANGELES (AP) A Northern California couple out walking their dog on their property stumbled across a modern-day bonanza: $10 million in rare, mint-condition gold coins buried in the shadow of an old tree.
Nearly all of the 1,427 coins, dating from 1847 to 1894, are in uncirculated, mint condition, said David Hall, co-founder of Professional Coin Grading Service of Santa Ana, which recently authenticated them. Although the face value of the gold pieces only adds up to more than $28,000, some of them are so rare that coin experts say they could fetch nearly $1 million apiece.
"I don't like to say once-in-a-lifetime for anything, but you don't get an opportunity to handle this kind of material, a treasure like this, ever," said veteran numismatist Don Kagin, who is representing the finders. "It's like they found the pot of gold at the end of the rainbow."
Kagin, whose family has been in the rare-coin business for 81 years, would say little about the couple other than that they are husband and wife, are middle-aged and have lived for several years on the rural property in California's Gold Country, where the coins were found. They have no idea who put them there, he said.
The pair are choosing to remain anonymous, Kagin said, in part to avoid a renewed gold rush to their property by modern-day prospectors armed with metal detectors.
Rally in pro-Russian region of Crimea decries the 'bandits' in Kiev forming new government
SEVASTOPOL, Ukraine (AP) Dozens of pro-Russian protesters rallied Tuesday in this Crimean Peninsula city, bitterly denouncing politicians in Kiev who are trying to form a new government, with some even calling for secession from Ukraine. A Russian lawmaker stoked their passions by promising that Moscow will protect them.
"Russia, save us!" they chanted.
The outburst of pro-Russian sentiment in the strategic peninsula on the Black Sea, home to a Russian naval base, came amid fears of economic collapse for Ukraine as the fractious foes of President Viktor Yanukovych failed to reach agreement on forming a new national government and said the task of assigning posts could not be completed before Thursday.
While Ukraine's politicians struggled to reorganize themselves in Kiev, a Russian flag had replaced the Ukrainian flag in front of the city council building in Sevastopol, 500 miles (800 kilometers) to the south of the capital. An armored personnel carrier and two trucks full of Russian troops made a rare appearance on the streets, vividly demonstrating Russian power in this port city where the Kremlin's Black Sea Fleet is based.
Some called on Moscow to protect them from the movement that drove Yanukovych from the capital three days ago.


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Consumer Price Index Jumps on Costlier Gas
WASHINGTON - Consumer prices rose last month as the cost of
gas increased by the largest amount since June 2009. But outside of
energy costs, there was little sign of widespread inflation.
The Labor Department says the Consumer Price Index rose 0.5
percent in December, the largest increase in 18 months. About 80
percent of the increase was due to an 8.5 percent rise in the
gasoline index, also the sharpest increase in 18 months. Food
prices ticked up 0.1 percent in December.
High unemployment and a weak economy are keeping prices in
check. Last year, the index rose by 1.5 percent, down from 2.7
percent in 2009.
Excluding the volatile food and energy categories, the so-called
core index moved up 0.1 percent in December for the second straight
month. In the past year, the core index rose by only 0.8 percent.

subset: commoncrawl


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Family doctors and general practice physicians can manage most endocrine patients, leaving endocrinologists to treat advanced disorders. And because it's time consuming, endocrinologists cannot treat as many patients per day as other physicians and therefore cannot make as much money. Endocrinologists also do not perform as many procedures as other specialists, Shapiro said.
"You make less money as an endocrinologist than you would as a general practice physician," Shapiro said. "Why would you want to train more to make less?"
Until physicians start earning more money or graduate from medical school with less debt, Ferrari is concerned that interest in endocrinology will continue to decrease.
"Will students end up picking specialties based on the availability of that specialty to help them pay off their debt quicker?" Ferrari said. "It's hard to know how much that weighs into [their decision]."
Dr. Glenn Crotty, chief operating officer of Charleston Area Medical Center, said CAMC has two endocrinologists and is looking to recruit four more, while there are only about 3,000 in the entire country.
With fewer specialty doctors in practice, patients have to jostle for limited available appointments, he said.
And since they likely aren't trained in West Virginia, the chances are greater that specialty doctors will set up practice near the place they last trained, Shapiro said.


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- Monkey Chimes includes:
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Perfect to add to Halloween collection, but expected the monkey to clap fast like in the movies.
[1 of 1 customers found this review helpful]
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[1 of 1 customers found this review helpful]
I bought this to sit on my table for Halloween. At night it bothered me so much, I had to put it in the garage. LOL Too many scary movies! It works well and it will be fun come Halloween night.
Have out in various areas and moves to different locations in house. This one is a classic along the lines of a Jack-in-the-box. Get it before out of stock. Very good value too.
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Experimental pKa Values of Buried Residues: Analysis with Continuum Methods and Role of Water Penetration Biophysical Journal, Volume 82, Issue 6, 1 June 2002, Pages 3289-3304 Carolyn A. Fitch, Daniel A. Karp, Kelly K. Lee, Wesley E. Stites, Eaton E. Lattman and E. Bertrand García-Moreno Abstract Lys-66 and Glu-66, buried in the hydrophobic interior of staphylococcal nuclease by mutagenesis, titrate with pKa values of 5.7 and 8.8, respectively (Dwyer et al., 2000, Biophys. J. 79:1610–1620; García-Moreno E. et al., 1997, Biophys. Chem. 64:211–224). Continuum calculations with static structures reproduced the pKa values when the protein interior was treated with a dielectric constant (ϵin) of 10. This high apparent polarizability can be rationalized in the case of Glu-66 in terms of internal water molecules, visible in crystallographic structures, hydrogen bonded to Glu-66. The water molecules are absent in structures with Lys-66; the high polarizability cannot be reconciled with the hydrophobic environment surrounding Lys-66. Equilibrium thermodynamic experiments showed that the Lys-66 mutant remained folded and native-like after ionization of the buried lysine. The high polarizability must therefore reflect water penetration, minor local structural rearrangement, or both. When in pKa calculations with continuum methods, the internal water molecules were treated explicitly, and allowed to relax in the field of the buried charged group, the pKa values of buried residues were reproduced with ϵin in the range 4–5. The calculations show that internal waters can modulate pKa values of buried residues effectively, and they support the hypothesis that the buried Lys-66 is in contact with internal waters even though these are not seen crystallographically. When only the one or two innermost water molecules were treated explicitly, ϵin of 5–7 reproduced the pKa values. These values of ϵin>4 imply that some conformational reorganization occurs concomitant with the ionization of the buried groups. Abstract | Full Text | PDF (294 kb) |
Stabilization of Internal Charges in a Protein: Water Penetration or Conformational Change? Biophysical Journal, Volume 87, Issue 6, 1 December 2004, Pages 3982-3994 Vladimir P. Denisov, Jamie L. Schlessman, Bertrand García-Moreno E. and Bertil Halle Abstract The ionizable amino acid side chains of proteins are usually located at the surface. However, in some proteins an ionizable group is embedded in an apolar internal region. Such buried ionizable groups destabilize the protein and may trigger conformational changes in response to pH variations. Because of the prohibitive energetic cost of transferring a charged group from water to an apolar medium, other stabilizing factors must be invoked, such as ionization-induced water penetration or structural changes. To examine the role of water penetration, we have measured the 17O and 2H magnetic relaxation dispersions (MRD) for the V66E and V66K mutants of staphylococcal nuclease, where glutamic acid and lysine residues are buried in predominantly apolar environments. At neutral pH, where these residues are uncharged, we find no evidence of buried water molecules near the mutation site. This contrasts with a previous cryogenic crystal structure of the V66E mutant, but is consistent with the room-temperature crystal structure reported here. MRD measurements at different pH values show that ionization of Glu-66 or Lys-66 is not accompanied by penetration of long-lived water molecules. On the other hand, the MRD data are consistent with a local conformational change in response to ionization of the internal residues. Abstract | Full Text | PDF (275 kb) |
Structural Reorganization Triggered by Charging of Lys Residues in the Hydrophobic Interior of a Protein Structure, Volume 20, Issue 6, 6 June 2012, Pages 1071-1085 Michael S. Chimenti, Victor S. Khangulov, Aaron C. Robinson, Annie Heroux, Ananya Majumdar, Jamie L. Schlessman and Bertrand García-Moreno Summary Structural consequences of ionization of residues buried in the hydrophobic interior of proteins were examined systematically in 25 proteins with internal Lys residues. Crystal structures showed that the ionizable groups are buried. NMR spectroscopy showed that in 2 of 25 cases studied, the ionization of an internal Lys unfolded the protein globally. In five cases, the internal charge triggered localized changes in structure and dynamics, and in three cases, it promoted partial or local unfolding. Remarkably, in 15 proteins, the ionization of the internal Lys had no detectable structural consequences. Highly stable proteins appear to be inherently capable of withstanding the presence of charge in their hydrophobic interior, without the need for specialized structural adaptations. The extent of structural reorganization paralleled loosely with global thermodynamic stability, suggesting that structure-based pKa calculations for buried residues could be improved by calculation of thermodynamic stability and by enhanced conformational sampling. Summary | Full Text | PDF (1410 kb) |
Copyright © 2010 Biophysical Society All rights reserved.
Biophysical Journal, Volume 99, Issue 10, 3430-3437, 17 November 2010
Martin A. Schroer†, Michael Paulus†, Christoph Jeworrek‡, Christina Krywka§, Saskia Schmacke†, Yong Zhai‡, D. C. Florian Wieland†, Christoph J. Sahle†, Michael Chimenti‖, Catherine A. Royer¶, Bertrand Garcia-Moreno‖, Metin Tolan† and Roland Winter‡, ,
† Fakultät Physik/DELTA, Technische Universität Dortmund, Dortmund, Germany
‡ Fakultät Chemie, Technische Universität Dortmund, Dortmund, Germany
§ Institut für Experimentelle und Angewandte Physik, Christian-Albrechts-Universität zu Kiel, Kiel, Germany
¶ Centre de Biochimie Structurale, Institut National de la Santé et de la Recherche Médicale U554, Centre National de la Recherche Scientifique/Unite Mixte de Recherche, 5048 Université de Montpellier, Montpellier, France
‖ Department of Biophysics, Johns Hopkins University, Baltimore, Maryland
A structural interpretation of the thermodynamic stability of proteins requires an understanding of the structural properties of the unfolded state. High-pressure small-angle x-ray scattering was used to measure the effects of temperature, pressure, denaturants, and stabilizing osmolytes on the radii of gyration of folded and unfolded state ensembles of staphylococcal nuclease. A set of variants with the internal Val-66 replaced with Ala, Tyr, or Arg was used to examine how changes in the volume and polarity of an internal microcavity affect the dimensions of the native state and the pressure sensitivity of the ensemble. The unfolded state ensembles achieved for these proteins with high pressure were more compact than those achieved at high temperature, and were all very sensitive to the presence of urea and glycerol. Substitutions at the hydrophobic core detectably altered the conformation of the protein, even in the folded state. The introduction of a charged residue, such as Arg, inside the hydrophobic interior of a protein could dramatically alter the structural properties, even those of the unfolded state. The data suggest that a charge at an internal position can interfere with the formation of transient hydrophobic clusters in the unfolded state, and ensure that the pressure-unfolded form of a protein occupies the maximum volume possible. Only at high temperatures does the radius of gyration of the unfolded state ensemble approach the value for a statistical random coil.


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View the article online at http://citywire.co.uk/wealth-manager/article/a648129
MPs argue Sants knighthood discredits honours system
by Alex Steger on Jan 03, 2013 at 07:56
MPs have hit out at the decision to award former Financial Services Authority (FSA) chief executive Hector Sants a knighthood claiming it discredits the honours system, according to reports.
The Financial Times reported that MPs Douglas Carswell, a Conservative MP for Surrey, and Pat McFadden, Labour MP and member of the Commons Treasury committee, criticised the decision, with Carswell telling the paper: 'a knighthood is becoming almost as debased a currency as the British pound'.
McFadden told the FT: 'At a time when the country is still paying for the financial crisis, I think most people will find it odd that someone in a key regulatory position during that period ends up being knighted – especially when British heroes like Mo Farah were not.'
The paper said Sants was thought to have been recommended for the knighthood by chancellor George Osborne, who persuaded him to revoke his decision to quit as head of the FSA after the 2010 election.
10 comments so far. Why not have your say?
Jan 03, 2013 at 08:42
I agree entirely& Osbourne was foolish to persuade him to stay on, especially
in view of the dismal record of failure by the FSA.
report thisJan 03, 2013 at 08:42
I agree entirely& Osbourne was foolish to persuade him to stay on, especially
in view of the dismal record of failure by the FSA.
report thisJan 03, 2013 at 08:51
I'm glad I'm not the only one who thinks that Sants's helm at FSA was a disgrace.Maybe Turner's peerage can be quashed too !
report thisJan 03, 2013 at 08:56
Whether we look at the big regulatory picture, or specific examples such as Arch cru, Sants has displayed a lack of integrity and low cunning that has single-handedly destroyed the FSA's reputation; not to mention UK financial services.
report thisJan 03, 2013 at 09:15
Hear, hear. But I don't imagine that the new-look FSA will be any different - same people, same pay, different name...
report thisJan 03, 2013 at 10:28
Rewarding unaccountable failure in leadership. Anonymous 2 - try same people, more money, different name. This is a disgrace. and demeansthe honour system. I look forward to the petition - I will sign.
report thisJan 03, 2013 at 11:01
All of the above - except the honours system has been discredited since inception. It's a game for apparatchiks, social climbers, narcissists and pawns. Anyone with any integrity or self-worth is not interested in being patronised or bribed by a 'here today, gone tomorrow ' prime minister in the name of 'royalty'.
report thisJan 03, 2013 at 11:39
Already made my position clear on this farce and proud to give my thoughts openly . How this guy gets a knighthood when he failed so spectacularly says everything about the honours list . A joke , but part of the trilogy that started with Borrie who stopped the max commission agreement as he said not having one would drive commissions down -- aye right --- then Howard Davies who never saw Eq Life coming . I did in early 1997 and my reward was a threatened writ ! Meanwhile IFAs pay dearly for this institutional incompetence .
report thisJan 03, 2013 at 12:22
Alan - admire both your prescience and your chutzpah. However, just because they are stupid and self-seeking doesn't mean they aren't dangerous, as your experience demonstrates. I've put my head above the parapet once too often and been blackballed by royal brown-nosers. Still I raise the archers' salute to them and their ilk.
report thisJan 03, 2013 at 12:34
Suggest you read http://realbusiness.co.uk/article/16901-2012-a-year-of-sporting-heroes-and-establishment-zeros
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A mesmerizing country of ancient civilization, Egypt's culture and mysterious past fascinate generation after generation. This captivating vacation combines ancient and more recent history, large cities and villages, fertile countryside and desert, a life-sustaining river and beautiful, blue sea. Your journey begins in Cairo, the most populated metro area in Africa; see Sphinx, Valley Temple, and the great Giza Pyramids, standing since approximately 2560 BC. Enjoy the included guided visit of the National Archaeological Museum as well as Coptic Cairo and the Saladin Citadel. Follow the Nile Delta to Alexandria on the Mediterranean Sea. Visit the Fort of Qait, the gardens of Montaza, and the new library. Following the Mediterranean coastal road, stop in El Alamein, where two decisive battles were fought during WWII, then carry on to Marsa Matrouh, a large waterfront town with beautiful white beaches. En route back to Cairo, visit one of the ancient Coptic monasteries and do some last-minute souvenir shopping at Khan-el-Khalili bazaar.
Price: $1,090.00 Single | $870.00 Double


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Brain Electrophysiological Patterns in Obesity
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There is growing evidence of behavioural and neurobiological overlaps between obesity and drug abuse. Reduction of the amplitude of P300, a component of event-related potentials (ERP) elicited by an oddball paradigm, is an electrophysiological characteristic and a marker of vulnerability in substance abuse. We want to determine whether obesity is associated with such electrophysiological features during an auditory oddball paradigm. We postulate that obesity could be associated with electrophysiological abnormalities that could be viewed as a possible vulnerability marker for food addiction.
Condition |
Obesity |
Study Type: | Observational |
Study Design: | Observational Model: Case Control |
Official Title: | ERP Study of Brain Electrophysiological Patterns in Obesity |
- Evaluation of amplitudes and latencies of the P300 complex of Event Related Potential during an oddball paradigm, in normal-weighted and obese subjects [ Designated as safety issue: No ]
Enrollment: | 69 |
Study Start Date: | January 2008 |
Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
Normal weighted
Ages Eligible for Study: | 20 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
a healthy but normal-weighted or obese population. Depressive state or eating disorders were carefully evaluated.
Inclusion Criteria:
- The inclusion criteria for the study are men and women aged 20-60 years, BMI 18.5-24.9 kg/m2 for control subjects and BMI>30 kg/m2 for obese subjects, stable body weight over the previous 3 months, report of sedentary or moderate physical activity
Exclusion Criteria:
- The exclusion criteria are pregnancy, post-menopausal women, any physiological or psychological illness that could influence the results, subjects likely to take medical drugs interfering with the electrophysiological parameters of the study, diabetes, hearing disorder, intense physical activity and report or evidence of excessive alcohol consumption, depressive state or eating disorders according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).
France | |
Centre de Recherche en Nutrition Humaine Rhone Alpes | |
Lyon, France, F69008 |
Principal Investigator: | Emmanuel DISSE, MD | CRNH Rhone-Alpes |
Responsible Party: | Dr Emmanuel DISSE, Centre de Recherche en Nutrition Humaine Rhone-Alpe |
ClinicalTrials.gov Identifier: | NCT00842569 History of Changes |
Other Study ID Numbers: | CRNHRA-09-001 |
Study First Received: | February 11, 2009 |
Last Updated: | February 11, 2009 |
Health Authority: | France: Direction Générale de la Santé |
Keywords provided by Centre de Recherche en Nutrition Humaine Rhone-Alpe:
obesity cognitive process reward P300 |
ERP Event-related potential during oddball paradigm brain electrophysiological patterns externalizing factor |
Additional relevant MeSH terms:
Obesity Overnutrition Nutrition Disorders |
Overweight Body Weight Signs and Symptoms |
ClinicalTrials.gov processed this record on March 11, 2014


text:
Last night Sir James came upstairs for the first time. In life, his bad hips prevented him from making the climb. At bedtime, I gently carried his floral tin of ashes to my room and set him by the bed. I placed one smooth black stone from Iceland on the tin.
You don't come around
C'mon talk
Oh, Jarle, my Norwegian earworm!
The not-asking
Valentine to my songbird
Argument against a virtue
The mug of white warmed milk. The overbred, ribboned dog. The kiss unkissed, or too dry, too tame. This life belongs to the wretched, the dirty. There's no sense in mending it, not now. Your life is no less or more a life than that of the woman hanging her husband's bleached boxers in the sun for the sixtieth, seventieth, hundredth time. What she remembers, you will never know.
Blonde ambitions
More fun, please, with a side
of ombré and razoring.
Tell no one of my dark past,
my ashy roots, mined silver.
It's my hair and I can curl
if I want to. You know what
they say about the little girl
with the curl in the middle
of her forehead, or you don't.
Chopped, cropped, ready
to co-opt stray laughter,
impertinent glances,
insouciant thinking, even
a bit of winking. Bring on
the parade of unremembrance,
rainbows all bows, no rain.
Dear, I made a pot roast last night in the slow cooker. I added vegetables, because vegetables are en vogue, if the food shows I watch are to be trusted. I shaved parsnips and carrots and made them smooth. I tried to imagine your face, the soft skin below the prickly indignant stubble. Maybe the only stubble you have is on your legs. Dear, if you would only write or call or find me in this great big world, I would know such things.
The day before Friday
How to keep moving
Try blasphemy
Breaking news
This just in:
King Richard III has been sleeping off
the winter of his discontent just below
the concrete of a municipal parking lot
in Leicester.


text:
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text:
Colón (kɒˈlɒn, Spanish koˈlɔn) | |
—n | |
1. | Former name: Aspinwall a port in Panama, at the Caribbean entrance to the Panama Canal. Chief Caribbean port. Pop: 157 000 (2005 est) |
2. | Archipiélago de Colón the official name of the Galápagos Islands |
colon co·lon (kō'lən)
n. pl. co·lons or co·la (-lə)
The division of the large intestine extending from the cecum to the rectum.
colon (kō'lən) Pronunciation Key
The longest part of the large intestine, extending from the cecum to the rectum. Water and electrolytes are absorbed, solidified, and prepared for elimination as feces in the colon. The colon also contains bacteria that help in the body's absorption of nutrients from digested material. |
A punctuation mark (:) used to introduce a description, an explanation, or a list. For example, "She would own only one kind of pet: a Siamese cat" and "The little boy announced that he wanted the following for his birthday: two sweaters, a new tent, and three toy cars."


text:
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text:
Big Island / Snorkel and Dive - Hawaii Manta Ray
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Pineapple Cheddar Spread Recipe
I came across this easy idea when looking for something new and unique to impress guests. The slightly sweet spread received rave reviews from friends. Try it with celery sticks or crackers the next time you need a fast appetizer.
Rebecca Pester
Beale Air Force Base, California
- 4 ounces cream cheese, softened
- 1/4 cup mayonnaise
- 1-1/2 teaspoons soy sauce
- 2 cups (8 ounces) shredded cheddar cheese
- 1 can (8 ounces) unsweetened crushed pineapple
- 1/2 cup chopped almonds, toasted
- 1/4 cup finely chopped green pepper
- 2 tablespoons finely chopped green onion
- Celery sticks
- In a small bowl, beat the cream cheese, mayonnaise and soy sauce until smooth. Beat in the cheddar cheese, pineapple, almonds, green pepper and onion. Serve with celery. Yield: 2-1/2 cups.
Originally published as Pineapple Cheddar Spread in Quick Cooking
March/April 2005, p37
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text:
We have recently acquired new software with the capability to upgrade many Volkswagen's and Audi engine computers. The software upgrades are on a vehicle by vehicle basis right now and horsepower gains do vary. For more information or to schedule a free vehicle scan and estimate contact Jeff @ 636-227-8887.
Service, Parts and Sales
Most vehicle manufacturers recommend changing the oil once a year or every 7,500 miles in passenger car and light truck gasoline engines. For diesel engines and turbocharged gasoline engines, the usual recommendation is every 3,000 miles or six months.
If you read the fine print, however, you'll discover that the once a year, 7,500 mile oil change is for vehicles that are driven under ideal circumstances. What most of us think of as "normal" driving is actually "severe service" driving. This includes frequent short trips (less than 10 miles, especially during cold weather), stop-and-go city traffic driving, driving in dusty conditions (gravel roads, etc.), and driving at sustained highway speeds during hot weather. For this type of driving, which is actually "severe service: driving, the recommendation is to change the oil every 3,000 miles or six months.
For maximum protection, most oil companies say to change the oil every 3,000 miles or three to six months regardless of what type of driving you do.
Truck fleets often monitor the condition of the oil in their vehicles by having samples analyzed periodically. Oil samples are sent to a laboratory that then analyzes the oil's viscosity and acid content. Oil is then burned in a device called a spectrometer that reveals various impurities in the oil. From all of this, a detailed report is generated that reveals the true condition of the oil.
Oil analysis is a great idea for fleets and trucks that hold a lot of oil. But most consumers would have a hard time justifying the cost. Having an oil sample analyzed typically costs $12 to $20 for the lab work and report. Most quick lube shops charge $16.95 to $19.95 for an oil change. So why spend your money on a report that will probably tell you your oil needs changing? Just change the oil every 3,000 miles and don't worry about it.
Regular oil changes for preventative maintenance are cheap insurance against engine wear, and will always save you money in the long run if you keep a car for more than three or four years. It's very uncommon to see an engine that has been well maintained with regular oil changes develop major bearing, ring, cam or valve problems under 100,000 miles.
To reduce the costs of vehicle ownership and maintenance, many car makers say the oil filter only needs to be replaced at every other oil change. Most mechanics will tell you this is false economy.
The oil filters on most engines today have been downsized to save weight, cost and space. The "standard" quart-sized filter that was once common on most engines has been replaced by a pint-sized (or smaller) filter. You don't have to be a rocket scientist to figure out that a smaller filter has less total filtering capacity. Even so, the little filters should be adequate for a 3,000 mile oil change intervals -- but may run out of capacity long before a second oil change at 6,000 or 15,000 miles.
Replacing the oil filter every time the oil is changed, therefore, is highly recommended.
An engine's main line of defense against abrasion and the premature wear it causes is the oil filter. The filter's job is to remove solid contaminants such as dirt, carbon and metal particles from the oil before they can damage bearing, journal and cylinder wall surfaces in the engine. The more dirt and other contaminants the filter can trap and hold, the better.
In today's engines, all the oil that's picked up by the oil pump is routed through the filter before it goes to the crankshaft bearings, cam bearings and valvetrain. This is called "full-flow" filtration. It's an efficient way of removing contaminants, and it assures only filtered oil is supplied to the engine. In time, though, accumulated dirt and debris trapped by the filter begin to obstruct the flow of oil. The filter should be changed before it reaches this point, which is why the filter needs to be replaced when the oil is changed.
If you wait too long to change the filter, there's a danger that it might become plugged. To prevent this from causing a catastrophic engine failure due to loss of lubrication, oil filters have a built-in safety device called a "bypass valve." When the pressure drop across the filter exceeds a predetermined value (which varies depending on the engine application), the bypass valve opens so oil can continue to flow to the engine. But this allows unfiltered oil to enter the engine. Any contaminants that find their way into the crankcase will be pumped through the engine and accelerate wear.
If you do your own oil changes, make sure you get the correct filter for your engine. Follow the filter manufacturer's listings in its catalog. Many filters that look the same on the outside have different internal valving. Many overhead cam engines, for example, require an "anti-drainback" valve in the filter to prevent oil from draining out of the filter when the engine is shut off. This allows oil pressure to reach critical engine parts more quickly when the engine is restarted. Filters that are mounted sideways on the engine typically require an anti-drainback valve.
CAUTION: The threads on a spin-on filter must also be the correct diameter and thread pitch (SAE or metric) for your engine. If you install a filter with SAE threads on an engine that requires metric threads (or vice versa), you can damage the threads that hold the oil filter in place. Mismatched threads can also allow the filter to work loose, which causes a sudden loss of oil pressure that may ruin your engine!
Some people say it's best to change the oil when the oil is hot (like right after driving), while others say it makes no difference. CAUTION: Hot oil is thinner and runs out faster but can also burn you if you're not careful. In any event, avoid unnecessary skin contact with oil because oil is a suspected carcinogen (causes cancer).
Changing the oil when it is cold may take a bit longer because the oil will drain more slowly from the engine, but there's no danger of being burned. Also, most of the oil will have drained down into the oil pan when the engine has sat for a period of time, which means you'll actually get a little more of the old oil out of the engine than if you attempt to drain it while it is still hot.
Used motor oil should be disposed of properly. The Environmental Protection Agency does not consider used motor oil to be a hazardous chemical, but it can foul ground water and does contain traces of lead. The best way to dispose of used motor oil is to take it to a service station, quick lube shop, parts store or other facility for recycling. Your old oil will either be rerefined into other lubricants or petroleum products, or burned as fuel.
Do not dump used motor oil on the ground, down a drain, into a storm sewer or place it in the trash. Many landfills will not accept used motor oil even if it is in a sealed container because it will eventually leak out into the ground. If you can't find an environmentally-acceptable way to dispose of the stuff, maybe you shouldn't be changing your own oil. Service facilities that do oil changes all have storage tanks and recycling programs to dispose of used oil.


text:
[Book Review] The Mounting Dread Of 'Revenge: Eleven Dark Tales' By Yoko Ogawa
Revenge: Eleven Dark Tales was originally published in Japan way back in 1998 (Komoku na shigai, Midara na tomurai) but over the past year, translations of individual stories from Yoko Ogawa's cryptic anthology have crept into classy American lit mags like Harper's, Zoetrope: All Story, and Guernica. Ogawa's highbrow, gothic style may not appeal to stalwart gorehounds, but she's a critics' darling, and fans of slow burn supernatural horror may want to sign up for this one. The new English translation by Stephen Snyder, released by Picador, hits American bookstores on January 29. Read on for the full review. READ MORE


text:
There's a lot to learn about Medicare and your options. The following includes many commonly asked questions about Medicare plans.
Don't see what you're looking for? If you're already a member of one of our health plans, just call Member Service at the number shown on the front of your ID card.
Not a member and still have questions? Just Contact Us. We'll be happy to answer any questions you may have about our Medicare Advantage, Medicare supplemental insurance, and Medicare Part D plans.
When can I enroll in a Medicare Advantage or Medicare Part D plan or change plans?
When can I enroll in a Blue Cross Blue Shield of Massachusetts' Medicare Supplement plan?
I understand that financial assistance may be available. How do I find out if I qualify for help?
What if my employer offers to continue my group health coverage after I retire?
Original MedicareA federally funded fee-for-service health plan that lets you go to any doctor, hospital, or other health care supplier who accepts Medicare and is accepting new Medicare patients. is a federally funded health insurance plan. It is designed for people age 65 or older and some disabled people under age 65. Medicare Part A pays for inpatient hospital care, skilled nursing facility care, and hospice careA special way of caring for people who are terminally ill, and for their family. This care includes physical care and counseling. Hospice care is covered under Medicare Part A (Hospital Insurance). . Medicare Part B pays for outpatient hospital careMedical or surgical care that Medicare Part B helps pay for and does not include an overnight hospital stay. , doctor visits, and many other medical services not covered by Part A.
With Original Medicare, you get easy access to care.
You can use any doctor or hospital that accepts Medicare (and most do)
Original Medicare doesn't require you to select a primary care providerA doctor who is trained to give you basic care. In many Medicare managed care plans, you must see your primary care doctor before you see any other health care provider. (PCP) or get a referral to seek care from a specialist
A Medicare Advantage plan is an alternative to Original Medicare and often Medicare Part D benefits which provides you with complete coverage for your Medicare benefits and often additional benefits beyond Original Medicare, such as routine vision care, routine dental coverage, and more. Many Medicare Advantage plans include Part D prescription drug coverage. Medicare Advantage plans are offered by private companies approved by Medicare.
Medicare Part D is a prescription drug option provided by Medicare-approved private insurance companies to help cover the cost of prescription drugs. Medicare offers prescription drug coverage to everyone with Medicare. Even if you don't take a lot of prescriptions now, you should still consider joining a Medicare drug plan. To get Medicare prescription drug coverage, you must join a plan offered by an insurance company or other private company approved by Medicare. Each plan can vary in cost and drugs covered. If you decide not to join a Medicare drug plan when you're first eligible, and you don't have other creditable prescription drug coverage, you will likely pay a late enrollment penalty when you do join.
There are two ways to get Medicare prescription drug coverage:
Medicare Prescription Drug Plans: These plans (sometimes called "PDPs") add drug coverage to Original Medicare, some Medicare Cost Plans, some Medicare Private Fee-for-Service (PFFS) Plans, and Medicare Medical Savings Account (MSA) Plans.
Medicare Advantage Plans (like an HMO or PPO) or other Medicare health plans that offer Medicare prescription drug coverage. You get all of your Part A and Part B coverage, and prescription drug coverage (Part D), through these plans. Medicare Advantage Plans with prescription drug coverage are sometimes called "MA-PDs."
To join a Medicare Prescription Drug Plan, you must have Medicare Part A or Part B. To join a Medicare Advantage Plan, you must have Part A and Part B. You must also live in the service area of the Medicare plan you want to join.
If you have employer or union coverage, call your benefits administrator before you make any changes, or before you sign up for any other coverage. If you drop your employer or union coverage, you may not be able to get it back. You also may not be able to drop your employer or union drug coverage without also dropping your employer or union health (doctor and hospital) coverage. If you drop coverage for yourself, you may also have to drop coverage for your spouse and dependents.
If you have limited income and resources, you may qualify for Extra Help to pay for Medicare prescription drug coverage. You may also be able to get help from your state.
You may join or leave a plan only at certain times. For example, each year you will be able to choose a different Medicare Part D prescription or Medicare Advantage planA health plan, such as a Medicare managed care plan (HMO or PPO) or Private Fee-for-Service plan offered by a private company with a Medicare contract. An alternative to the Original Medicare Plan. during an annual electionYour decision to join or leave Original Medicare or a Medicare Advantage plan. period. If you are eligible for both Medicare and Medicaid, you may change plans at any time.
The annual election period for Medicare Part D and Medicare Advantage plans is October 15 through December 7.
The annual disenrollment period for Medicare Advantage plans is typically January 1 through February 14, annually. During this time a Medicare Advantage member may disenroll from their plan and choose Original Medicare and a Part D prescription drug plan. For more information, contact Member Service at 1-800-200-4255 (TTY: 1-800-522-1254), February 15 through September 30, 8:00 a.m. to 8:00 p.m. ET, Monday through Friday; October 1 through February 14, 8:00 a.m. to 8:00 p.m. ET, seven days a week.
These insurance plans are offered by private insurance companies to help you cover health care costs, including co-insurance, copayments and deductibles—"gaps" in Original Medicare coverage.
Open enrollment in Medicare supplement plans vary by plan. You can enroll in a BCBSMA Medex plan at any point during the year. You have, by law, at least 30 days to review a Medicare supplement policy. If you decide you don't want the coverage, you can get a full refund of any premiums you've paid during this "free look" period.
Visit Find a Doctor and search for your provider(s) to find out if they will accept your coverage.
If you have both Medicare and Medicaid, you already qualify for low-income assistance to help pay for your prescriptions. If you don't qualify for Medicaid, you may still qualify for some assistance. If you're a Massachusetts resident, contact the Prescription Advantage Program at 1-800-AGE-INFO (1-800-243-4636), (TTY: 1-877-610-0241), Monday through Friday, 9 a.m. to 5 p.m. ET.
If you aren't getting extra help, you can see if you can qualify by calling:
1-800-MEDICARE (1-800-633-4227) (TTY: 1-877-486-2048) 24 hours a day/seven days a week
The Massachusetts Department of Elder Affair's SHINE program office at 1-800-AGE-INFO (243-4636)
The Social Security Administration at 1-800-772-1213 (TTY: 1-800-325-0778) Monday through Friday, 7:00 a.m. to 7:00 p.m. ET
Yes, you may have the option to have these premiums deducted from your Social Security check (just like your Part B premium). If you are enrolled in an employer plan you are ineligible for the deduction from your Social Security check.
If your employer offers to continue your group health coverage after you retire, carefully weigh your options and consider Medicare coverage alternatives available to you as an individual. If you decline your group health coverage you may not be able to return to it if you change your mind later. Ask your benefits administrator for more information.


text:
Subspecialty Careers: Critical Care Medicine
The Discipline
Critical care medicine encompasses the diagnosis and treatment of a wide variety of clinical problems representing the extreme of human disease. Critically ill patients require intensive care by a coordinated team. The critical care specialist (intensivist) may be the primary provider of care or a consultant. The intensivist needs to be competent not only in a broad range of conditions common among critically ill patients but also with the technological procedures and devices used in the intensive care setting. The care of critically ill patients raises many complicated ethical and social issues, and the intensivist must be competent in areas such as end-of-life decisions, advance directives, estimating prognosis, and counseling of patients and their families.
Important procedural skills for the critical care medicine specialist include advanced cardiac life support, arterial blood gas sampling and interpretation, bedside pulmonary function, mechanical ventilation, placement of arterial and central venous lines, insertion of temporary pacemaker, endotracheal intubation, placement of pulmonary artery catheter, and interpretation of waveforms.
Training (via Internal Medicine)
Training in critical care medicine is most commonly pursued as part of a combined 3-year subspecialty fellowship in pulmonary and critical care medicine, after which the trainee is eligible for subspecialty certification in both pulmonary medicine and critical care medicine. In addition, a physician interested in critical care medicine can pursue training by alternative routes besides linking critical care with pulmonary medicine training. Such alternative routes include: (1) a two-year accredited fellowship in critical care medicine after internal medicine residency; (2) two years of fellowship training in advanced general internal medicine (that include at least six months of critical care medicine) plus one year of accredited fellowship training in critical care medicine; or (3) two years of accredited fellowship training in a subspecialty of internal medicine (three years for cardiovascular disease or gastrointestinal disease) plus one year of accredited clinical fellowship training in critical care medicine.
Training Positions
For the 2010-2011 academic year, there are 33 stand-alone ACGME-accredited training programs in Critical Care Medicine with 194 active positions. Thirty-two percent of the trainees are female and 25% are U.S. medical graduates. There are also 134 programs that offer combined training in Pulmonary Medicine and Critical Care.
The American Board of Internal Medicine, ABIM, offers certification in critical care medicine. Certificates of Added Qualifications are also awarded from the American Board of Surgery, American Board of Pediatrics, and the American Board of Anesthesiology.
Major Professional Societies
Society of Critical Care Medicine
701 Lee Street, Suite 200
Des Plaines, IL 60016
Phone: (847) 827-6869
American Thoracic Society
61 Broadway
New York, NY 10006-2755
Phone: (212) 315-8600
American College of Chest Physicians
3300 Dundee Road
Northbrook, Illinois 60062-2348
Phone: (847) 498-1400
Major Publications
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The peninsula LAUNDRY FACILITIES |
We guaranty you that you will not see
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15 & 25 AMPS & TV . Our water filtration and sterilization plant provides you with potable water in every tap. Our showers (hot water) and facilities are the cleanest and best you will find in your travels. SHADED AREAS Included for your pleasure we have B.B.Q. shade, picnic tables and free games such as a horse shoe pit. BIG CLEAN RV SPACES CLEAN SHOWER AND TOILET LOTS OF ROOM ROAD INFO Our destination is located north of Los Barriles, by clicking on the blue word Map, and the other pages that you will encounter from that page. You will find all the required info to get to us. This been said, big low riding motor homes should take it very easy; the road is safe for the unit and passengers as long as you drive slowly. When you get to the end of the highway turn right, you only have 500 meters of paved street to your camping spot. Children are so welcomed that camping is free for them. Pets are also welcome only if you pick after them. A "Hide-a-Way" off the beaten track between La Paz and Los Cabos. Located north of Los Barriles and Punta Pescadero but still part of the east cape region. The
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fishing and bottom fishing for dorado, rooster fish, red snapper and
any other fish that comes by to bite is only a few steps away from your
suite or camping spot at Spear fishing is welcomed only if is done while free diving and hunting predators only. At El Cardonal´s Hide-a-Way we recommend "Catch and Release" if the fish can be released without any harm and practice this policy after you get your meal. Because we do not have bad currents or undertow in our region swimming, kayaking or any other water sport is very safe. Whales and dolphins are ever present in our waters and love to be looked at from the beach or a boat. At our Coral Point (said to be the best in Baja according to a world renowned underwater photographer) with its 7 different types of coral that provide food and habitat to millions of different species of marine life is the perfect place to do underwater photography while snorkeling and diving. Our sandy beach is free of vendors so you can fully enjoy the wonderful feeling of been at the beach alone in a place where the sun or the stars shine 350 days a year and where the moon comes up over the sea to provide a wonderful (sexy) romantic ambiance. For
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Our guest's The best camping RATESFOR 2 adults Children under 14 FREE Wild Camping:
night Full Hook Ups Extra adult: 2.00 US$ea. FREE Wi-Fi TV 3.00 US$ / Sem. Price for longer stays are available on demand. Barter |


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Bad Ol Puddy Tat! Cartoons
Artist description:
Someone I grew up watching! Tweety bird with some shading added. The earliest versions of the Looney Tunes characters had very little shading, so I added a little for depth!
Ol Sylvester the cat is up to no good, so be vewy vewy carefoo! LOL!
Created Feb 22, 2012. Unless noted Copyright 2012
Whitemorn .
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This is one of my favorite caracter , I even have a cat just like (gros minet)...I also had tweety but he die from old age.....great drawing....5/5
I remember him, very funny, when twitter first came out, i though, i bet they got the name from tweety.5/5
Oh - oh.... looks like the cat has him cornered this time!!! Somehow... he never was "eaten"!!?!?!? LOL!!! Love it! 5/5!!!!
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Too know me is to love me..
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On Sat, Jun 16, 2012 at 9:05 AM, Eche said:
Cause you never know when you're gonna go...
On Thu, Jun 14, 2012 at 10:45 AM, JJ299 said:
Life's a bitch && then u die...that's why we puff la
JJ299 is a woman from VA . She has been member of this site for 22 months.
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Thursday, August 23, 2012 the Office of Student Development at Nyack College NYC enjoyed a one-day retreat at the Blue Mountain Christian Retreat in New Ringgold, Pennsylvania.
The Student Government, Club and Organization leaders spent the day relaxing, bonding, and being encouraged with leadership training by ATS Assistant Professor of Pastoral Ministries Jeff Quinn, Associate Dean of Student Life, Rev. Charles Hammond and the Office of Student Development staff.
The Vice President of the Student Government Association Marie Owens said, "The retreat was wonderful and I found it spiritually moving as well as intellectually stimulating".
There was plenty of free time to fellowship and explore the beautiful landscape. Everyone had a wonderful time and returned to the NYC campus rejuvenated and ready for the Fall 2012 semester.


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LSE nears LCH acquisition at €15 share
24 Dec 2012
The London Stock Exchange Group Monday agreed to pay €15 per share for a 60% stake in clearing house LCH.Clearnet as the companies extend negotiations and inch towards an agreement that has been delayed by new European regulations.
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From The Wall Street Journal


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'This is a great first doll as it is cuddly and soft and has cute colours on it.'
Kiddicare Staff Expert - Peterborough
'Side safety catches quite loose so they easily slip forwards and prevent folding up to put away. You have...'
Nan - Devon
'I have bought this for my 20 month old granddaughter for Christmas and am sure she will love it as she...'
Accompanist - Worcestershire
©Kiddicare 2014


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Vivienne Tam and HP notebook collabo...that's hot
Hewlett-Packard and world-renowned Asian fashion designer Vivienne Tam have been working together to create the HP Vivienne Tam Special Edition notebook. However, anyone attending Tam's fashion show during New York's Fashion Week at Bryant Park Tuesday has probably already seen it.
The special-edition notebook--which looks to be an HP mini-note, except it's sporting a 10-inch screen--debuted with the usual fanfare a fashion show receives at Fashion Week, but with a high-tech twist.
Models sashayed onto the catwalk workin' the designer notebook as a clutch purse, while looking fierce in Tam's clothing.
The notebook is gleaming red and bursting with peony flowers--a signature staple of Tam's collection--on the lid. The peony design is then meticulously carried inside the notebook, under the keypad. The laptop also features a extra special enter key that bears the Chinese symbol for double happiness. The design was inspired by Tam's "China Chic" style, which is recognized from the runways in Milan to the Olympics in Beijing and represents her personal mantra to live well and be beautiful. The notebook also features a complimentary embroidered storage sleeve that helps keep the exterior protected while being carried as a clutch.
The "digital clutch" represents the first time a computer company has partnered with a fashion designer to create a notebook PC as well as have it debut at a fashion show. In addition to the design of the notebook, Tam worked with HP to design its accessories and packaging. … Read more


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tedster - 3:00 am on Dec 4, 2012 (gmt 0)
Seems like there's a refresh in Penguin shortly after Panda the past few months.
According to our Update records [webmasterworld.com] Penguin has only been updated 2 times all year, whereas Panda has seen 9 updates. In fact, the gap between the last two Penguin updates was 6 months, but Panda saw 6 updates in that same period. So I have trouble seeing a connection between the two.


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VOTE: Are Bears still a Super Bowl contender?
Bears fans, are you still convinced this team is a Super Bowl contender?
No, Packers exposed the Bears' many flaws (2922 responses)
Yes, it's one game and there's plenty of time to make tweaks (1006 responses)
3928 total responses
(Results not scientific)
This poll is closed to voting.


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COLFAX, La. (KALB News Channel 5) – An Alexandria woman is caught red handed, according to the Grant Parish Sheriff's Office.
The Grant Parish Sheriff's Office said they have arrested Nicole Leach, 32 of Alexandria for aggravated burglary.
A homeowner in Colfax called and reported a woman in their home. They gave a full description and then escaped the premises. Deputies said they arrived, while the burglary was in progress.
Leach is accused of breaking out a window to the back door, forcing her way in the home and firing a pistol into the wall of the home.


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Product Number: | PY58073 |
Item Price: | $6.99 |
Availability: | In Stock |
Shipping Weight: | 1.35 lbs. |
Primos Control Freak is a Dual Action product controls both bacteria-caused odors such as body odor and no-bacterial odors such as smoke and food odors. Primos Control Freak Complete Coverage works on contact and instantly removes odors and keeps them gone for up to 24 hours.
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Good one! Share your favorites and earn zulily credit. see detailsconnect
Dora the Explorer knows a thing or two about style, and the more polka dots and flowers the better. That's why this adorable yoke top and leggings set has plenty of them, so a little lady can look her most charming.


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John StreufertDeputy Chief Information Officer and Chief Information Security OfficerState Department
Streufert led a team that developed and deployed the Risk Scoring Program, which gives administrators the ability to continuously monitor risks to State's information technology infrastructure. Streufert's efforts significantly lowered IT security risks, even in divisions outside his control, such as embassies.
The program, which goes beyond the reporting requirements mandated by the Federal Information Security Management Act, constantly scans for vulnerabilities, tags weak configurations, fixes the biggest problems first and publishes monthly grades.
"John's impact has spanned far beyond the boundaries of the State Department's" initiative, said Teresa Carlson, vice president of U.S. federal government sales at Microsoft. "He has been the catalyst for a growing movement around the revamping of government IT security laws, policies, standards and implementation practices."
Read more about the 2010 Federal 100 award winners.
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Rutrell Yasin is is a freelance technology writer for GCN.
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As there is a limited number of rooms in Locanda Correr, you won't feel lost here. Santa Lucia Station is a station close by. Accessible within a short radius from this location, Goldoni Theatre and Rossini Theatre can be reached on foot. In the area surrounding this accommodation, Sospiri Bridge can be found. Other interesting points nearby are San Marco and Doge's Palace. The distance from here to Basilica di San Marco is 0.2 km (0.1 miles).
At Locanda Correr, breakfast is free for guests. A concierge service is part of the list of services that you can benefit from here. Book a stay in one of the 5 rooms.
Warmth can be controlled via an air conditioning system in the rooms of Locanda Correr. Guests here benefit from wireless high-speed Internet access (complimentary). Some rooms are liberally provided with an Italian Frette sheet set.
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Check-in: | From 14:00 Check-out: Until 11:00 |
Internet: | Wired Internet, Wireless high-speed Internet access (complimentary) |
Rooms: | 5 |
Services: |
General facilities: |
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Loss-making Scandinavian airline SAS said it would slash costs and sell assets to secure its future following media reports it was in financial difficulties.SAS, which made a SEK1.6 billion kronor (USD$241 million) pre-tax loss in 2011, has been struggling for years against cut-price rivals such as Ryanair, industry overcapacity and more recently high jet fuel costs and an economic slowdown.SAS, part-owned by Norway, Sweden and Denmark, said it was working on a plan that would cut costs, reduce complexity and ease the effect of a possible equity write-down due to pension accounting changes.The move comes as rivals, such as Lufthansa and Air France-KLM, have also embarked on cost cutting initiatives, trimmed profit forecasts and reduced plans to expand capacity and fleets.SAS's latest plan will keep it flying for a while, but analysts believe the airline only has a long-term future as part of a bigger alliance."The problem for now is that there isn't anyone willing to acquire it," said Jacob Pedersen, analyst at Sydbank. "I expect SAS to survive as a company, but it will be a bumpy road."The airline said it made a third-quarter pre-tax profit of SEK568 million kronor, bringing forward its results after reports it was in financial trouble led to a suspension of share trading.SLIM DOWNSAS said the plan is expected to yield approximately SEK3 billion kronor in earnings before tax, adding it will also sell assets of around SEK3 billion kronor, but provided no further details.The airline said it was currently in negotiations regarding the extension and amount of its revolving credit facility.SAS said it had liquid funds of SEK2.4 billion kronor and available credit facilities of SEK4.7 billion kronor, which will expire in June 2013.SAS, which faces a hit to shareholder equity of up to SEK10.7 billion kronor when new pension accounting rules are introduced in November 2013, is not the only airline to be suffering.In August Cathay Pacific Airways posted its worst first-half loss since 2003, and International Airlines Group, the owner of British Airways and Iberia, reported a group operating loss of EUR€253 million (USD$328million) in the six months to the end of June.The International Air Transport Association (IATA) expects the USD$630 billion airline industry to make a net profit of USD$4.1 billion this year, up from an earlier forecast of USD$3 billion but still less than half the USD$8.4 billion achieved in 2011.IATA said industry profits would rise next year to USD$7.5 billion, helped by passenger traffic expansion of 4.5 percent. Source: Reuters
Gravity always wins!


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Get a quick snapshot of featured investment and economic commentary from the Calamos investment team. View Now >
Global Co-CIOs John P. Calamos, Sr. and Gary D. Black, offer their take on opportunities in the global marketplace. View Now >
Access analysis and commentary on timely investment topics.
Perspectives on investing, the economy and the global financial markets. View Now >
In a piece for Investment Week, John P. Calamos, Sr. explains why core convertible allocations may be the answer to investing in a rising, but still volatile, equity market.
As reported by The National Herald, Ambassador Christos Panagopoulos presented the 2013 Capital Link Leadership Award to John Calamos for his contribution to fostering closer business relations between Greece and the United States.
This article by Citywire includes quotes from an interview with John Calamos, Sr. and Eli Pars, Co-Portfolio Manager, in which they discussed convertible securities and the current market environment.


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no minimum purchase required!*
Some exclusions may apply.
*No minimum purchase required. Use promotion code IPEB43H3 at checkout. Promotion/source code box is located in step 4 of checkout. Valid at eastbay.com, by phone or mail. Does not apply to prior purchases or open orders and cannot be combined with any other offers. May not be used toward purchase of GiftCards or team orders. Promotion may be modified or terminated at any time. Certain restrictions and exclusions may apply. Some items are not eligible for discount and will indicate "excluded from discount" on the product's description page. Offer expires 03/20/2014 (03:59 am CT).
Be the First to Know! Get up-to-the-minute info on the latest product launches, special offers and sales events by signing up for Eastbay emails or by requesting our free catalog.
Make it easier for little ones to take control of their outfit - the Converse All Star Simple Slip-On is lace-free and designed with built-in support under the tongue to give feet a snug fit without the restrictions of tying things up. Made with a canvas upper that's embroidered with the All Star logo and paired with a rubber sole. |


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Connecticut College News
Channel 8 News highlights College´s green initiatives
02/18/2009Connecticut College´s environmental and sustainability initiatives were highlighted in a WTNH-TV Channel 8 (ABC) news segment that aired Feb. 17. In the segment, Tyler Dunham ´09 discusses the college´s participation in the national RecycleMania competition and Amy Cabaniss, campus environmental coordinator, is interviewed about the college´s efforts to offset energy usage. Additionally, Heather Day ´09 and Sunil Bhatia, associate professor of human development, were interviewed live Feb. 18 on WTIC-TV Fox 61 News. To view the segment. Both winners of the college´s Dr. Martin Luther King Jr. Service Awards, Day and Bhatia spoke about their own commitment to social justice and racial equality.
For media inquiries, please contact:
Deborah MacDonnell (860) 439-2504, firstname.lastname@example.com


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Since its publication in 1962, Carlos Fuentes' novel, "Aura," remains not merely an object of academic interest but a continuous source of ... Show synopsis
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At 5:38 a.m. on Friday, May 3, a gobbler pulls his head out from under his wing. He listens. Songbirds. Then a few crows squawk. He strains to hear that soft, seductive voice of a pretty hen. In a nearby tree, another gobbler utters a low yelp, almost imperceptible. That's all he hears.
Both turkeys stand up and stretch their wings. They fan out, but only for a second, then fold up to lay every feather perfectly in place. More than 20 minutes pass in silence. The gobblers stretch their necks to peer at the ground. A deer drifts by. Then a skunk.
At 6:01 a.m., the sun is about to peek over the horizon, and the gobbler is overdue for a morning shoutout. "Gobbellobbelll"
Article Photos
Photo submitted to the Times Observer
Spring gobbler
Russell's Steve Sorensen proudly shows the 19-pound gobbler he bagged on Friday, May 3.
One big bird pitches to the ground, then the other. Both gobblers patrol the area of their roost trees, but only one has anything to say today. "Gobbellobbelll"
A few hens were in the vicinity yesterday. Maybe they're in the field. So, the gobblers walk across a ravine and snake through the berry bushes at the field's edge, and into the green, luscious grass. Hens love it here. This early in the morning the wet grass provides moisture and the cool temperature slows the bugs that live there. It's an easy, succulent breakfast. "Gobbellobbelll"
"Yelp, yelp, yelp. Cluck. Cluck." There she is, still over in the woods, across the ravine but downhill from our roost site. "Gobbellobbelll. Here we are, come on over! Gobbellobbelll"
Fact Box
When the Everyday Hunter isn't hunting, he's thinking about hunting, talking about hunting, dreaming about hunting, writing about hunting, or wishing he were hunting. If you want to tell him exactly where your favorite hunting spot is, contact him at email@example.com. This column and others can be accessed online at www.EverydayHunter.com.
Maybe if we fan out she'll see us. "Gobbellobbelll"
"Yelp, yelp. Purrrrrrrrrrrrrr. Cluck. Purrrrrrrrrrrrrr."
She's not coming yet, but she will. I'll fan out again. "Gobbellobbelll" I'm irresistible. She wants me.
Though the gobbler can't count the minutes that pass, his ears are tuned for more yelps. They do not come. She must be on her way over here.
A few minutes later, "Yelp, yelp. Cluck. Purrrrrrrrrrrrrr."
She hasn't moved. "Gobbellobbelll" His proud call is met with silence. Minutes pass again.
"Yelp, yelp. Cluck. Purrrrrrrrrrrrrr." She's staying put.
A few minutes later a cacophony of inharmonious sounds surge across the ravine. High pitches. Low pitches. Sweet. Raspy. Hard clucks and loud, rattling purrs. A bunch of hens. They're all over there, and they all want me. I'll head on over. Maybe they'll meet me halfway.
The gobblers saunter to the edge of the field and stop to listen. The loud hen voices erupt again. They haven't moved. They're still over there. The gobblers step into the woods, head toward the ravine, and pause at the brink to listen and watch. The hen chorus bursts forth a third time, and the gobblers hurry across.
The first head pops up from the ravine; he knows right where the hens are. A few more steps and he stops to look. They've gone silent, but they can't be far away. The second gobbler catches up, and turns sideways. A 9-inch beard juts from his chest.
Boom! A thunderous noise. The second gobbler flops and is still. The blast shocks the first into sounding off. "Gobbellobbelll" A man stands up where those hens were supposed to be. Muscular wings thrust the gobbler out over the ravine. Every beat pumps nearly twenty pounds of turkey toward the treetops.
The man straddles the gobbler on the ground. The gobbler kicks and tries to spread his wings, but his strength is reduced to uncoordinated impulses.
Somewhere, down in the valley, a gobbler glides to a landing and folds his wings. He stands as still as a statue for five minutes before walking away.
Life goes on. Tomorrow will be another new day, and he'll greet it with another throaty gobble.