text:
The Citizens Monitoring Council says it has found evidence of an illegal dumping system constructed some years ago on CTS property — presumably used to funnel hazardous waste off the property. The system may have allowed contaminants such as trichloroethylene (TCE), benzene, and vinyl chloride to enter ground and surface water, as well as residential drinking-water supplies. Relying largely on hazardous-waste tracking documents filed with the state, the lawsuit alleges that CTS failed to account for over 1,000,000 pounds of the toxic solvent and known carcinogen, TCE, which presumably was released to the environment over the course of several years (and still contaminates now unused residential wells in the vicinity). The lawsuit also aims to show that, as part of its efforts to sell the facility and surrounding land, CTS Corp. represented to realtors and the community that the site "has been rendered in an environmentally clean condition." Part of the property was subsequently sold to become the Southside Village housing development.
Remediation at the shuttered electroplating facility has moved forward fitfully over the years (see the Xpress CTS file here). A soil vapor extraction system — installed in 2006 to remove and treat contaminants present in the soil under the plant — was unexpectedly shut down last May when presumed thieves broke into the CTS facility and removed copper pipes and wires, including those that serviced the system. After cutting off the lock on the gate at the facility, the vandals/thieves installed their own lock, perhaps planning to return.
The system was not repaired, adding to CTS neighbors' long-standing concerns for their health and safety, according to MacQueen, spokesperson for the CTS Citizen's Monitoring Council. Meanwhile, MacQueen told Xpress, levels of the contaminant TCE in surface water near the site remain high, as measured in samples collected last month by a group of UNCA environmental studies students, who also found TCE in the tissue of trees downslope from the facility. "Nothing has changed; things have only grown worse," says MacQueen. "Why is nothing being done to safeguard surface water? The state standard for TCE in surface water is 81 parts per billion; we're at over 1,000 ppb now. It's inexcusable."
For its part, EPA says it has plans for confirmation sampling of groundwater, "to see whether the machine is still needed," according to press officer James Pinkney. The EPA's emergency on-scene coordinator Carter Williamson concurs, saying that the soil vapor extractor has recovered some 6,000 pounds of volatile organic compounds at the site since it was installed — but that lately the volume of contaminants recovered has declined steadily, to the point that evaluation of its usefulness is needed now.
"We don't know if a [contamination] source is still present [underground]," Williamson told Xpress. "Sampling will tell." Meantime, he says, the search is on for "a panel of experts in VOCs in fractured bedrock" to help create a plan for proceeding with remediation.
Representatives at CTS Corp. were not available for comment at press time.
Read more articles in:
NewsSubscribe to XpressMail. Free Sneak Peek. Every Week.
Want to know what's coming out in Xpress this week before the paper even hits the stands?
We've got your free sneak peek, along with deals available in XpressMail, our weekly email newsletter. (It's the best we can do without time travel.)
Related Articles
Make a comment


text:
UNK Quick Links Quick Links A-Z Website Listing Office of the Chancellor Campus Maps UNK Factbook Calendar of Events Policies & Procedures Contact Information Registrar's Office UNK Alert Undergraduate Graduate International eCampus Scholarships & Fin. Aid Academic Affairs American Democracy Undergraduate Studies International Education Study Abroad Academic Calendar Colleges & Departments Computer Use Policy Course Catalog Library eCampus Classes Schedule of Classes Transcripts Firefly Academic Calendar Blackboard LoperMail eCampus Helpdesk (ITS) Major/Advisor Change (ugrad) Student Union Student Government LoperCAREERS Telecommunications The Antelope Online KLPR Radio UNK ID Card MyBLUE Blackboard Ektron Login Faculty Senate Firefly Future Catalog Helpdesk (ITS) Email Staff Senate Telephone Directory UNK ID Card myBlue Assessment Current Catalog Faculty Handbook Policies & Procedures The Antelope Online UNK Today UNK Factbook Business & Finance Academic & Career Services Contact Information Employment at UNK Human Resources ITS Police/Parking Services Dining Services Alumni Association NU Foundation NU System
Sample Parental Consent Form for Non-Therapeutic Research That is Less than Minimal Risk
Write all consent forms using letterhead stationery. If the consent form is more than one page, provide a place for the subject to initial each page, and write the IRB number at the top of each page.
Title of the Research Study: Assessing the Impact of Speech Rate and Performance in Dysarthric Speakers
You are invited to permit your child to participate in this research study. The following information is provided in order to help you to make an informed decision whether or not to allow your child to participate. If you have any questions, please do not hesitate to ask.
Your child is eligible to participate in this study because your child has a neurologically based speech disorder called dysarthria.
The purpose of this study is to investigate how changes in speech rate affect the function of the soft palate during speech. The soft palate is the back of the roof of the mouth.
This study will take approximately one hour of your child's time. In order to assess soft palate function during speech we will place a small nasal mask over your child's nose. Your child will be able to breathe through this mask at all times. We will also place a small plastic tube at the corner of his/her mouth. When your child speaks at various rates by repeating word strings such as "Buy Bobby a Puppy," we will measure air pressure in the mouth and the amount of airflow through the nose. This information, in turn, will allow us to assess the functioning of the soft palate. We will also record your child's speech. All of these measures are considered routine clinical procedures.
There are no known risks associated with this research.
As a result of participation in this research, it is possible that your child may learn to speak more clearly by controlling the rate of his/her speech. The information obtained from this study may help us to better understand the impact of speech rate on the functioning of the soft palate during speech.
Any information obtained during this study which could identify your child will be kept strictly confidential. The information obtained in this study may be published in scientific journals or presented at scientific meetings, but the data will contain no identifying information.
Your child's rights as a research subject have been explained to you. If you have any additional questions concerning your child's rights, you may contact the University of Nebraska at Kearney Institutional Review Board (IRB), telephone 308-865-8843.
You are free to decide not to enroll your child in this study or to withdraw your child at any time without adversely affecting your child's or your relationship with the investigator or the University of Nebraska. Your decision will not result in any loss of benefits to which your child is otherwise entitled.
Documentation of Informed Consent
You are voluntarily making a decision whether or not to allow your child to participate in this research study. Your signature certifies that you have agreed to allow your child to participate having read and understood the information presented. You will be given a copy of this consent form to keep.
____________________________________ __________________________ Signature of Parent Date
In my judgment the parent/legal guardian is voluntarily and knowingly giving informed consent and possesses the legal capacity to give informed consent to participate in this research study.
____________________________________ __________________________ Signature of Investigator Date
Identification of Investigators
Primary Investigator
Mike M. Robinson, Ph.D. Off: 865-1000
Approved 07/04/10

subset: commoncrawl


text:
Sports Headlines
'Triumphents' conquer Colorado Triathlon | Array Print Array |
Written by Rocky Beltz |
Wednesday, 17 July 2013 00:00 |
By CODY SHRUM Linn County News Most people can't say that they have completed a triathlon in their lives, or that they were crazy enough to even attempt one, but four local women with two Coloradans can say they have. Jenny Reynolds with daughters Cheyanne and Savannah, and Robin Bortzfield with daughter Riki Barr and Barr's friend Beth Graves all competed in the first Tri Bella triathlon on June 29. The competition took place at Cherry Creek State Park in Aurora, Colo. near Denver. The sponsoring company was Without Limits Productions. Three hundred twenty-five women competed in the triathlon. Want to read more? Log into read the online edition here Linn County News
Last Updated on Wednesday, 17 July 2013 11:10 |


text:
Get an overview of the application of pharmacokinetic concepts to all stages of drug development. The focus will be on the practical application of pharmacokinetic principles in the design and conducting and interpreting preclinical and clinical pharmacokinetic studies. Areas to be covered will include pharmacokinetic concepts (absorption, distribution, metabolism, and elimination), pharmacodynamics, regulatory requirements, and guidance for in vitro and in vivo studies, and practical examples of preclinical and clinical pharmacokinetic and pharmacodynamic analyses. This entry-level course will be appropriate for individuals with a background in biological sciences who contribute to the design, conduct, analysis or interpretation of pharmacokinetic studies or who have an interest in the role of pharmacokinetics in drug development.
Course Number: BIOL-40176 Credit: 3 units
Receive emails about upcoming Life Sciences events and courses.
Manage your email subscriptions via My Extension.
Section ID | Fee | Status | ||
03/31/14 - 06/02/14 (Click to show details) | Online | 101037 | $650.00 | Add to Cart |


text:
Brooklyn >
Health Care Professionals > Inch Knocker, LLCMon-Sat 9am-5pm ; Sun Closed
Neighborhoods: Borough Park
Sign in with Facebook Sign in with Facebook to see what your friends are up to!
Do you have a review of Inch Knocker, LLC on your blog? If you include the Citysearch image link (shown below) in your post, we'll automatically link to your review from the business profile page. Here's how our Linkback system works:
The Linkback system is free and automatic. It's really that easy.
To link to our business profile page, copy the html below to your web page.


text:
Student Financial Aid
Student Services > Student Financial Aid > Policies > Financial Aid for Classes other than at KUMC
Student Services > Student Financial Aid > Policies > Financial Aid for Classes other than at KUMC
There are times a student may need to take courses at a school other than KUMC. If those courses are part of the KUMC curriculum and will apply toward the student's degree at KUMC, the student may be eligible to receive financial aid to cover the cost of those courses as long as they are enrolled at least half time in KUMC courses.
If students are required to take courses at another institution while in pursuit of his/her degree at KUMC, and the student wants financial aid to cover these expenses, the student will need to contact the Student Financial Aid Office before the course work begins. After meeting with a financial aid counselor to discuss enrollment, the Student Financial Aid Office will require the student and the student's academic advisor to complete and sign an Advisor Certification Form. Once that has been submitted, the KUMC Student Financial Aid Office will enter into a Consortium Agreement with the other institution at which the student is enrolling. This Consortium Agreement is a written document between the two institutions confirming that KUMC, as the Home Institution, agrees to award financial aid for the course work at the Host Institution, and that the Host Institution will not be providing aid to the student for this time period.
These are the instances in which aid can be awarded to the student while the student is attending another institution:
1. The course is required for the student's degree at KUMC, is part of the KUMC curriculum, and not offered at KUMC for that specific term.
2. The course is required for the student's degree at KUMC, is part of the KUMC curriculum, and the course is full.
3. The student's advisor recommends that the student take the course at another institution because the course will enhance the student's degree and provide valuable preparation for the student's chosen profession.
4. There may be other instances depending on the situation. Each is handled on a case-by-case basis.
The student is responsible for:
1. Completing all necessary paperwork prior to the start of the course.
2. Paying tuition, fees and other expenses assessed by the host school.
3. Notifying KUMC Student Financial Aid and the host institution of any changes to enrollment once the student has submitted the paperwork.
4. Maintaining Satisfactory Academic Progress and degree-seeking status at KUMC.
5. Requesting academic transcripts be sent to KUMC from the host school at the end of the semester, once grades are posted and official transcripts are available.
KUMC Student Financial Aid Office is responsible for:
1. Maintaining a record of the consortium agreement and other applicable documents.
2. Certifying degree seeking status and monitoring Satisfactory Academic Progress.
3. Providing student consumer information.
4. Processing the student's financial aid application and awarding funds based on the student's individual eligibility.
5. Providing a copy of the consortium agreement to the KUMC Registrar for enrollment certification purposes.
6. Calculating Return of Title IV Aid when applicable.
The Host Institution is responsible for:
1. Providing documentation of student's enrollment at the host institution and cost of attendance for the term specified on the consortium agreement.
2. Providing student consumer information.
3. Notifying KUMC if the student fails to enroll in the approved courses, or drops, withdraws, or substitutes course work.
University of Kansas - Lawrence campus
Students who take courses at the University of Kansas Lawrence campus do not need to complete a Consortium Agreement. While each campus processes financial aid at the respective campuses, both campuses process financial aid under the same school code, and the financial aid system will only allow a student to receive financial aid from one campus. Therefore, there is no risk of a student receiving financial aid from both the KUMC and KU financial aid offices.
University of Kansas Continuing Education Courses
If the student is enrolling in an eligible Continuing Education course for the fall/spring that has been approved by the student's advisor, is part of the student's KUMC curriculum, and is necessary for the student's degree at KUMC, the student and the student's KUMC academic advisor are required to complete the Advisor Certification Form. Any Continuing Education course taken must be completed within the standard enrollment dates of the semester for which the student is receiving financial aid for the course. For example, if the student is taking the Continuing Education course and receiving aid for the fall semester, the student must begin and end the course within the stated dates of the fall semester. Please contact the Student Financial Aid Office for additional paperwork required for students approved to take courses through Continuing Education to ensure timely disbursement of funds. Continuing Education courses will not be funded for summer semesters.
The Great Plains IDEA program is a consortium of 8 universities and provides an online 36-credit hour Master of Science in Dietetics and Nutrition degree.
· Students participating in the Great Plains IDEA are eligible to receive financial aid for the courses taken at any of the 8 participating universities.
· KUMC students participating in the Great Plains IDEA will be enrolled in KUMC courses at KUMC, although the on-line instruction can come from faculty at any of the universities in this agreement
· Students will not be enrolling in any campus other than their HOME campus
· KUMC students participating in the Great Plains IDEA will pay tuition and fees directly to KUMC
Since all students in this program will be enrolled in KUMC courses and pay KUMC tuition and fees, no additional consortium agreement is necessary for these students unless the courses they take or the location of the courses are not part of the Great Plains IDEA.
NEXus is a consortium of universities providing instruction to students on-line students in the School of Nursing.
· Students participating in the NEXus program are eligible to receive financial aid for the courses taken at any of the participating universities
· KUMC students participating in the NEXus program will enroll in courses at the campus the course will be taught. If the student is taking a class at another location, the HOST school will manage the enrollment for that course.
· The Registrar's Office will not enroll students in any course that is being taken at a HOST school while the student is taking the course
· Once courses are completed at the HOST school, the course will transfer in to KUMC, at which it will be added to their transcript
· KUMC students participating in the NEXus program will pay tuition and fees to the HOST school
Since students in this program may be enrolled at any of the participating campuses, a consortium agreement is required for all courses taken at other NEXus locations. The School of Nursing will notify the Student Financial Aid Office when a student is scheduled to be enrolled at different locations. Since no enrollment will show up for these courses until the course is completed, if the student or School of Nursing fails to notify the Student Financial Aid Office of the student's participation in these courses, the student's financial aid will only be processed for those courses taken at KUMC.
* Students who were admitted to KUMC prior to the Spring 2010, and who were told they could receive funding for pre-requisite courses, will continue to receive funding for those courses until they have completed their degree. Graduate Nursing students will be allowed funding for a graduate level Statistics course if one is not completed prior to enrollment at KUMC.


text:
In the Spotlight
The Police Department held the first "Coffee with a Cop" event on Thursday, February 27 at Tags Café. Community members had an opportunity to ask questions and talk about important issues with the new Chief of Police. The next event will be at Sweet Heart Café, 9894 Colerain Avenue, on Wednesday, March 19 at 9am.
Upcoming Events
3/3/2014 7:30 a.m. Picnic Shelter Reservations Begin
3/11/2014 6:00 p.m. Regular Meeting of the Board of Trustees, Ch. 8
3/18/2014 7:00 p.m. Zoning Commission
3/25/2014 5:30 p.m. Work Session Meeting of the Board of Trustees, Ch. 8
Latest News
Shelter Rentals Begin March 3rd
Colerain Township has been selected as one of the Business Courier's 2014 Healthiest Employers of Greater Cincinnati finalist!


text:
welcome, Guest
lisez en Français | online shop | useful links | sitemap | contact us | home
Show article content
Print article content
Hide article content
Print article content
by Werner Lohr, API-Promo GTZ, Germany
The objective of this study was to create higher awareness in those who are engaged in the planning and implementation of beekeeping projects in developing countries regarding the transfer of beekeeping technology and know-how from the North to the South; and the integration of local micro enterprises (the so-called "informal sector") for the production of inputs for beekeeping, in order to assure sustainability of projects.
API-Promo GTZ analysed 35 beekeeping projects, beekeeping activities, and beekeeping components as a part of integrated projects carried out by different aid organisations during the past 20 years in Africa, Latin America and Asia. This analysis was carried out by studying project documents and literature, interviewing people involved, and visiting projects.
About 75% of the evaluated projects had a very low impact on the local beekeeping industry. 35% failed totally to have any impact. Most projects worked well as long as the consultants or volunteers looked after the implementation. In most cases this changed immediately after their departure or when projects were phased out.
Among the many reasons identified for the failure of projects, the following are of special interest:
· Sector policies on national level: in most countries governments showed, and still show, only a little interest in supporting the beekeeping industry;
· Feasibility studies: traditional beekeeping systems and their importance in the rural economy, and social value were not profoundly analysed;
· Project planning: bees and beekeeping techniques were the main focal points rather than the people: their sex, age, socio-economic status, potentials, capabilities and interests in beekeeping.
· Economic viability: income people might earn through beekeeping was highly over-estimated. Natural resources and absorbing capacity of markets were not properly analysed.
· Time horizons of projects and backstopping: the time of implementation was too short, and monitoring and follow-up were not actioned correctly.
· Professionality of supporting agencies: in most cases extensionists are not practical beekeepers, but solely theoreticians an modernists. This results in low confidence among rural people and ineffective extension services.
· Technology and know-how transfer: most projects concluded right at the beginning that existing traditional systems were not apt to develop the industry, and concentrated on changing these in a short time and in big steps. The degree of applied appropriate technologies was very low;
· Factor cost: the inputs used to develop the industry were too expensive, non-appropriate and not available at village level.
To stress the last two points and give an example related to the problems linked to the introduction of the world famous top-bar hive.
Most project conceptionalists are convinced that the top-bar hive solves most of the problems related to traditional beekeeping and honey hunting, for all groups and individuals, in all developing countries. For them the top-bar hive is simple in design (low-technology) and in handling , the hive has almost all the advantages necessary for good management and sustainable beekeeping and the costs of the hive, are, in their eyes, low. As a consequence most projects promoted top-bar hive technology.
But, the reality is different. In most cases they overlook that honey hunters and traditional beekeepers:
· are not interested in intensive management of hives;
· are not able to handle top-bar hives;
· want just bees, honey and money in combination with a minimum of work and risk;
· avoid spending money for any kind of inputs, they prefer to make their own hives or barter;
· are individualists and risk minimisers who do not like to depend on others;
· do not like to expose their hives to the public;
· are afraid of thieves and vandalism if hives are not hung in trees or carefully watched;
· know that bees might become very aggressive and dangerous;
· depend very much on social acceptance of what they do concerning beekeeping.
When top-bar hive projects started it was very soon recognised in most cases that the production of top-bar hives was only possible by carpenters with plenty of equipment. To profit from cost reduction when producing large numbers of hives, the manufacturing of hives was given to bigger companies normally in towns. To provide beekeepers with the necessary inputs, a 'hive tourism' and credit system had to be started: as most farmers have no means of buying and transporting hives, most hives are taken by project vehicles from the manufacturers to the beekeepers.
When a project was phased out credits were not repaid, revolving funds stopped working, new hives were not bought, and broken ones not repaired. In many cases termites put an end to the hives!
To avoid project failure due to high input costs and non-appropriate technologies, and to guarantee high sustainability:
· traditional beekeeping systems and the technical skills of the people should be studied more profoundly before a project starts;
· different resource persons, familiar with the rural and social-economic conditions, and development aspects should be consulted;
· beekeepers, honey hunters and newcomers to beekeeping need different levels of training and equipment according to their problems, capabilities and resources;
· as soon as possible local people have to be trained as trainers and project conductors and the project must become their own project. People from implementation agencies should only act in the background as facilitators;
· the integration of the rural micro industries in producing inputs is a must in case beekeeping equipment cannot be produced by beekeepers. Training of carpenters, blacksmiths, tailors, and potters should be part of any project;
· simple and easy to handle technology with a minimum of maintenance should dominate;
· locally available materials, also modern material liked by people as well as by bees (for example cement plastic, metal, iron sheets), and suitable honey containers (recycled bottles, jars, plastic bags) should be integrated if input costs allow this;
· hives must be installed where the bee pasture is best and where the bees like to live to guarantee high occupation rates, high yields and a minimum of absconding;
· hive products (comb honey, bottle honey, wax, pollen) should first be used to satisfy the local market before other markets are addressed.
If these points re respected before and during project implementation, quite a significant number of people may be encouraged to start beekeeping. In the beginning it is very important, that people own bees and experience success in producing and selling honey. If they are convinced that beekeeping fits them, by and by they will become beekeepers and further redevelopment of techniques, management methods and the integration of environmental aspects will automatically follow.
[Bees for Development Journal #48]


text:
Jump to main content.
National Center for Environmental Economics
Contact Us Search: All EPA NCEE
EPA Office
Ref. Number
Document Type
Title (Downloadable)
Assessment Topic
powered by
Regulatory Economic Analyses All NCEE Web
Study establishes a model approach for analyzing costs and benefits associated with EPA efforts to deal with the relation of human health to drinking water quality.


text:
As of Thursday, April 11, 2013
© Copyright 2014
Clayton News Daily
LOVEJOY — Organizers are expecting sunny skies and mild weather Saturday to kick off Lovejoy's Third Annual Block Party series.
"We just want everyone to come out and have fun," said Lovejoy police Chief Michael Harris.
The series is a monthly community gathering with free food and games in Mayor's Park, 11620 Hastings Bridge Road.
Each city council member plans to host one party in the series through August as an appreciation to the city's residents and businesses.
Lovejoy is the southernmost municipality in Clayton County, with a population of roughly 5,000.
"We normally have a pretty good turnout," said Harris.
He expects attendance to surpass 200 people Saturday as it did in 2012. The party is from 1 p.m. until 3 p.m.
"I normally do the cooking," he said.
Harris and Lovejoy police Sgt. Michael Gaddis plan to grill hot dogs and hamburgers for the free event. Future block parties are set for May 11, June 8, July 13 and Aug. 10.
More like this story
- Lovejoy fall festival greeted with mild, sunny weather ( September 18, 2013 )
- Sunshine greets Lovejoy block party ( April 16, 2013 )
- Lovejoy fall festival greeted with mild, sunny weather ( September 17, 2013 )
- Lovejoy block party, dedication Saturday ( August 8, 2013 )
- Lovejoy approves FY14 budget ( May 15, 2013 )


text: FORTUNE -- It's been seven months since Fabio Zambelli retired SetteB.IT, the Italian-language blog with which he'd been covering Apple (AAPL) for more than five years. But he's still tracking the company's progress. When Fortune released its annual listing of America's 500 largest companies over the weekend -- a list that showed Apple rising from 35 in 2011 to an all-time-high of 17 in 2012 -- Zambelli commemorated the event with the graphic reproduced above. You can see the original on his Twitter account. You can read Fortune's Apple write-up here.


text:
Moles, or nevi, are spots on the skin. They can be flat or raised, large or small, oval or round, mottled or even-colored. Their shade is caused by pigment cells, called melanocytes, and they can range from tan to pink, brown, or black. They can appear anywhere on the skin. No one knows exactly what causes moles, but almost everyone has at least a few.
About one in every hundred babies is born with a mole. These birthmark moles are called congenital nevi. Other types of moles are most likely to develop in the first 20 years of life, though it's possible to get moles at any age.
Yes. Moles generally go through a life cycle of about 50 years of gradual change. Typically they start out flat and freckle-like, then enlarge over time. They commonly become darker during the teen years, during pregnancy, and upon exposure to the sun. Some develop hairs, and some become more raised and lighter in color.
Most moles aren't dangerous, but almost 50 percent of melanomas start in moles. Since melanomas are very rare in young children, there's no need to panic if your child has a mole. But it's still a good idea to monitor moles carefully. Melanomas do start showing up as early as the teen years.
Some moles are more dangerous than others. A congenital mole — one your child was born with — is more prone to developing melanoma. Your doctor should examine any congenital moles at well-child visits and refer you to a dermatologist if she thinks they need further evaluation.
Another type of mole that's more likely to develop melanoma is a dysplastic nevi, or atypical mole. These are larger than a pencil eraser and irregular in shape. Usually they have uneven color with lighter, uneven borders and dark brown centers. Sometimes there are black dots at the edges. Your child's doctor or dermatologist will want to examine any atypical moles.
Besides having your doctor or dermatologist monitor your child's moles during regular visits, you'll want to keep an eye on your child's moles yourself. The American Academy of Dermatology has a few guidelines to help you determine whether a mole needs prompt professional attention. They're called the ABCDs:
There's usually no need, but if your child has a mole that's uncomfortable because it's in an area that's often rubbed or that's embarrassing, talk with a dermatologist about the options. She may be able to easily remove the mole in her office.
It's mostly a matter of genes, but sun exposure can increase the number of moles and darken the ones that already exist, especially in those with lighter skin. So you can try to keep your child out of the sun during peak daylight hours and make sure he has sunscreen on before he heads outdoors. You might also choose parks and playgrounds with lots of shade and encourage him to wear wide-brimmed hats and long-sleeved shirts and pants whenever possible.


text:
Hermitude - The Powerstation, Auckland
The Powerstation, Auckland
22 Feb 2014
Doors open 8:00pm
Chet Faker
Fron $59.00
Hermitude return to New Zealand this February alongside Chet Faker. Their final stop, Auckland. Tickets on sale now.
Sat 15 Mar Sietta - Album Launch - Railway Club, Darwin The Railway Club, Darwin Sietta |
Fri 4 Apr Jimblah - Phoenix Album Launch - Melbourne Shebeen, Melbourne Jimblah |
Sat 5 Apr Jimblah - Phoenix Album Launch - Adelaide Pirie St Social Club, Adelaide Jimblah |


text:
- About
- Admissions
- Academics
- Student Life
- Faculty & Research
- Alumni & Friends
What about all the other stuff? Being a Tufts University graduate student in Boston means more than just hitting the books and lectures. Here are resources, links and guides for getting around, meeting fellow students, and where to turn when you need a computer fixed, a late night latte or an internship.
- Health Sciences Campus
- Find out about dining, libraries, fitness and other resources dedicated to the Boston Health Sciences Campus
- Health Services
- Health Insurance, Immunization Requirements and Counseling
- Student Council
- Meet your student representatives and find out how they can help you
- Student Organizations
- List and direct to full list on orgs page
- Living in Boston
- Parking, MBTA, Housing, Boston Touristy stuff, Mayor's office, Sommervile/Other residential areas
Campus Safety
View the Annual Public Safety Report on Tufts University.
Friedman Bulletin Board
Need an iClicker? Want to discuss final exams? Looking to sell that textbook you no longer need? Searing for a roommate? Care to share an interesting research project? Look no further than the Friedman Bulletin Board. What was once an e-list, is now a forum for you to interact with others in the Friedman Community. Friedman Bulletin Board


text:
A young Hasidic Jewish woman is pressured into an arrange levirate marriage to an older widower.
Free Event
Tai is 17 years old. Naim is 20. She's Israeli. He's Palestinian. She lives in Jerusalem. He lives in Gaza. Only 60 miles separate them but how many bombings, check-points, sleepless nights and bloodstained days stand between them?


text:
Bob Valvano's comments on Kevin Ware's injury and the Louisville broadcast are a must read
Earlier today we detailed the various coverage of Kevin Ware's awful injury ranging from the live CBS broadcast to ESPN's decision not to air the injury to some online outlets and their editorial decisions on how to cover such a traumatic event. Thankfully, Ware underwent successful surgery and the injury is not believed to be career-threatening. For the most part, the networks did what you would hope in being extra careful in choosing to air the injury, knowing full well that anyone who really wants to see it can find it on a thousand internet sites.
The toughest challenge is for the broadcasters and CBS largely handled the situation respectfully. Another broadcast group that had to describe the events live was the Louisville radio team. ESPN Radio host Bob Valvano serve as the team's radio analyst. His comments after the game provide insight into something no broadcaster can prepare for and the overwhelming emotion of the moment. Even after the game, Valvano recounts Louisville players crying in the locker room and how even the Louisivlle broadcasters were moved to tears by what they witnessed. Valvano posted the following on his Facebook page and here's the statement in full...
no comments


text:
We're sorry, Boa Moss Green Sandals is no longer available
Why not try one of these instead?
I'm being swallowed by a boa constrictor and gosh he's awfully cute! More than just a stylish sandal, Boa features a scaly friend on the Velcro clasp.
Available in whole sizes UK3/US4 through UK12/US13
Please note: you are ordering in UK size. The shoes will arrive with the US size on the box and the sole of the shoe. The UK size is US size - 1.
- comfy, breathable, flexible inner sole
- flexible rubber outer sole
- velvety-soft leather
- easy on-off Velcro Z-strap for a just-right fit
- padded collars for comfort
- shoes weigh less than 150g
- this style runs true to size; good for medium to wide feet
product code:
This product is dispatched to you by Livie & Luca.
MAINLAND UK | order now and receive this item on or before | price |
Free Delivery | Monday 24 March | FREEFREEFREEFREE |
NON-MAINLAND UK | estimated delivery | price |
Highlands/Islands of Scotland |
2-5 days from dispatch
£1.75$3.49€2.25$3.15 |
N Ireland |
2-5 days from dispatch
£1.75$3.49€2.25$3.15 |
Other UK Islands |
2-5 days from dispatch
£3.95$7.87€5.10$7.11 |
INTERNATIONAL DELIVERY | estimated delivery | price |
Western Europe |
2-5 days from dispatch
£4.45$8.87€5.74$8.02 |
Rest of Europe |
5-10 days from dispatch
£4.45$8.87€5.74$8.02 |
USA & Canada |
5-10 days from dispatch
£6.95$13.86€8.97$12.52 |
Far East & Australasia |
5-10 days from dispatch
£6.95$13.86€8.97$12.52 |
Rest of World |
5-14 days from dispatch
£6.95$13.86€8.97$12.52 |
You have 28 days, from receipt of cancellable goods, to notify the seller if you wish to cancel your order or exchange an item.
Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty.
Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based.


text:
Rams take down OHS in 5A playoffs
Oxford boy's basketball coach Drew Tyler pointed out the positives of his Chargers and a season that saw them advance to the Class 5A North Half tournament at Indianola-Gentry. It was hard to be critical of much the Chargers have done the last two weeks of the season even after they lost 61-34 to Jackson's Provine in the North Half semifinals Friday night. (more…) (February 21, 2011, Page 8)


text:
Copyright for this gallery photo belongs solely to Donna LaMattino Pagakis . Images may not be copied, downloaded, or used in any way without the expressed, written permission of the photographer.
Congratulations to ALL the February Finalists and WINNERS!
The Flower FieldsCarlsbad, CaliforniaMarch 25, 2013
RAW / Handheld / Aperture Priority / -1/3 ECCanon EF100mm f/2.8L Macro IS USM Lens F 2.8 @ 1/8000 ISO 400
© Donna LaMattino Pagakis
Read Photo Discussion | Contact Donna Donna's Premium Gallery | Get Your Premium Gallery


text:
skip to main
skip to sidebar
Coloring and coloring pages
Coloring pages for boys and girls. coloring sheets pages and activities for kids
coloring pictures
drawings of children doing gymnastics coloring
drawings of children doing gymnastics coloring:
children make stretching
drawings of children doing gymnastics coloring
0 comments:
Post a Comment
Older Post
Newer Post
Subscribe to:
Post Comments (Atom)
coloring pictures
zoo coloring pages for kids
zoo coloring pages for kids, Save, Print and Color this Free Printable Zoo Coloring Pages zoo coloring pages for kids
jungle animals coloring pages for kids
jungle animals coloring pages for kids , donkey, elephant and giraffe to print and color free jungle animals coloring pages for kids
precious moments graduation coloring pages
precious moments graduation coloring pages , A precious moments girl who has finished her school studies precious moments graduation col...
ladder coloring page
ladder coloring page , ladder commonly made of wood, metal or fibreglass, but they have been known to be made of tough plastic. ladder co...
baby looney tunes coloring sheets
baby looney tunes coloring sheets , tweety, lola bunny and bugs, silvester and taz playing with balloons baby looney tunes coloring shee...
fan coloring pages for kids
fan coloring pages for kids , a machine for producing airflow, often for cooling fan coloring pages for kids
New in coloring and coloring
Coloring animals
Coloring flowers
coloring for girls
Coloring picture Barbie
Coloring princess
coloring for boys
Coloring tools
super heroes coloring pages
coloring cartoons
Coloring picture Barbie
Coloring Andy Pandy
Coloring baby looney tunes
Coloring picture bob sponge
Coloring pocoyo
coloring disney
Alice in wordeland
princess disney
winnie the pooh
coloring preschool
Coloring circus
Coloring clothes
Musical instruments coloring pages
Coloring jobs
Coloring family pictures
printable tales coloring pages
coloring pocoyo
coloring holidays
Coloring christmas pictures
Coloring Father´s day
Coloring mother´s day
All coloring pictures
( 135 )
( 2 )
( 91 )
( 27 )
( 15 )
( 537 )
( 1 )
( 15 )
( 5 )
( 4 )
( 16 )
( 35 )
( 242 )
hello kitty dressed in witch coloring sheets
hello kitty coloring sheets
picture hello kitty coloring
hello kitty next to a cake coloring sheets
bambi and thumper coloring
bambi and faline kissing coloring sheets
bluebelle coloring sheets
buzz lightyear coloring alphabet
minnie mouse with spices coloring
minnie mouse picture coloring
bambi and thumper coloring pages
turtle bites bambi coloring sheets
letter y sesame street coloring sheets
letter x sesame street coloring sheets
letter w sesame strret coloring pages
letter v sesame street coloring sheets
letter u sesame strret coloring pages
letter t sesame street coloring sheets
letter s sesame street coloring
letter k with kangaroo
letter j sesame street to color
letter i sesame street coloring sheets
letter r sesame street coloring sheets
letter q sesame street coloring pages
letter p sesame street coloring sheets
letter o sesame street coloring sheets
letter n sesame street coloring
letter m sesame street coloring pages
letter l sesame street coloring
letter h sesame street coloring pages
letter g sesame street coloring pages
letter f sesame street to color
letter e sesame street coloring sheets
letter d sesame street coloring
letter c sesame street coloring
letter b sesame street coloring sheets
vowel a to color
alphabet mickey mouse coloring
princess in the castle coloring
number one coloring
number 3 coloring pages
number 2 coloring sheets
number 4 coloring pages
number 6 to color
number 5 coloring sheets
number 7 coloring pages
number 8 coloring pages
number 9 coloring sheets
minnie mouse with butterfly coloring
number 10 coloring pages
minnie mouse looking in the mirror
minnie mouse with brushes coloring
witch minnie mouse coloring
olympic torch coloring pages
buffalo coloring pages
snoopy picture coloring sheets
minnie mouse coloring pages
volleyball for coloring drawing
minnie mouse coloring sheets
drawing of diver coloring
drawing of child playing football coloring
precious moments girl coloring sheets
gymnast coloring
the little prince coloring sheets
precious moments angel coloring pages
alphabet coloring pages
cherries coloring pages
witch with broom coloring pages
baseball clubs coloring pages
trash coloring sheets
forest coloring pages
bonsai coloring sheets
wedding coloring pages
pocket coloring sheets
diploma of graduation coloring pages
bidet coloring sheets
santa claus picture coloring
santa claus coloring sheets
thanksgiving day precious moments coloring
drawing of child in the hospital coloring pages
pins coloring
passport coloring
Hansel and Gretel coloring
Angel with flag precious moments coloring
christmas tree coloring
waxes box coloring
shepherd coloring pages
child jesus picture coloring
minnie mouse christmas coloring sheets
mickey mouse christmas coloring pages
asking in class coloring pages
christmas star coloring sheets
Cat picture coloring
peacock coloring
baby donald coloring
baby mickey mouse coloring
cinderella christmas coloring
christmas house picture coloring sheets
buzz lightyear in christmas coloring
picture of snow white coloring sheets
picture christmas tree coloring sheets
picture of angel in christmas coloring sheets
woody christmas drawing coloring sheets
drawing christmas ornaments coloring
drawing holly coloring pages
101 dalmatian christmas drawing for coloring
coloring christmas tree drawing
drawing of tulips coloring
daisy drawing coloring
girl under the rain in precious moments coloring
flower drawing to color
drawings of children doing gymnastics coloring
picture of girl in the dentist coloring pages
drawing of children playing coloring
drawing of child in the medical coloring sheets
boy showering coloring sheets drawing
child eating coloring drawing
drawing of a girl going to school coloring sheets
drawing of little girl washing hands coloring shee...
drawing of girl sleeping coloring
drawing of breast obscures girl coloring pages
gift box drawing coloring sheets
professor of precious moments coloring
princess of precious moments coloring sheets
parents of precious moments coloring sheets
precious moments bride coloring sheets
picture of soccer coloring
precious moments working coloring boy
coloring child of precious moments
baby mickey mouse coloring
baby goofy coloring
duck pond coloring pages
drawing of child playing rugby coloring
drawing of karate coloring
girl sleeping with doll coloring pages
baby clothes coloring
baby daisy coloring
budgie coloring
picture of hockey coloring
precious moments girl dressed in princess coloring...
girl playing in the sand of precious moments color...
girl graduate of precious moments coloring
precious moments love coloring
rabbits and carrots precious moments coloring
baby precious moments coloring
precious moments angel coloring
rugby player coloring pages
golf player coloring
drawing for coloring of footballer
drawing of windsurf coloring pages
tennis coloring
drawing of tennis coloring pages
drawing of high jump coloring: jumper with cutter ...
child playing basketball coloring
drawing of swimming coloring
drawing of karateka coloring pages
drawing of basketball player coloring
shooting basket coloring pages
picture of handball coloring pages
picture of athletics coloring
babies piolin and silvestre coloring
bambi coloring
colors in english coloring
coloring house for kids
cradle coloring
boy with kite coloring
coloring electric guitar
a good patient coloring
apple coloring
candle coloring
girl on scooter coloring
cow coloring pages
babies minniey mickey mouse coloring
Coloring ladybug
dancer custom coloring
japanese coloring
coloring seal at the circus
coloring Christmas candle
bouquet coloring pages
children painting coloring pages
child dreaming coloring
children playing cards coloring
dress drawing coloring
hammer drawing coloring
deer drawing coloring
owl drawing coloring
cutting girl in class coloring pages
baby pluto coloring
girl with ducklings coloring
playing hide and seek coloring pages
indian woman coloring pages
vegetables coloring
dutch coloring pages
gondola coloring pages
scottish coloring
juice picture coloring
beehive picture coloring
seawing coloring
sea horse coloring
good morning coloring
welcome home coloring
rabbit coloring
american flag coloring
teddy bear coloring pages
marionette coloring
witch with apple coloring
olives coloring
angel of school coloring
baby minie mouse coloring
clam coloring
backpack coloring
peg-top coloring
ufo coloring
locomotive coloring
hot air ballon coloring
truck coloring
ship picture coloring
airplane picture coloring
rocket coloring
pram coloring
bike coloring
teacher explaining coloring
first holy communion coloring
pelican coloring
loobster coloring
child's room coloring
seagull coloring
caring brother coloring
frankestein face coloring
beans coloring
animal cell coloring
flier precious moments coloring
elder coloring
poppy coloring
cotton coloring
seaweed coloring
bathrobe coloring
chees coloring
eagle coloring pages
tap water coloring
airport coloring
dna coloring
( 44 )
( 4 )
( 171 )
( 229 )
( 126 )
( 103 )


text:
U.S. MNT Arrive in Miami, Get Set For Opening Match of Hexagonal
Feb. 7, 2005
Miami (Feb. 7, 2005) - The U.S. Men's National Team is making a brief stop in Miami en route to Trinidad, spending around 36 hours in Southern Florida. Thirteen players from the training camp in Carson arrived in Miami just before midnight Saturday evening, then met up with the European-based contingent for a one-hour training session Sunday afternoon. The team trained at 10 a.m. at the University of Miami, then joined goalkeeper Kasey Keller, who arrived Monday afternoon from Germany, at Miami International Airport. The 23-man squad that is expected to arrive in Port of Spain just after 9 p.m. local time. The U.S. opens play in the final round hexagonal of 2006 FIFA World Cup qualifying Feb. 9 against Trinidad & Tobago. Kickoff at the Queen's Park Oval is set for 2:30 p.m. ET (3:30 p.m. local), and the match will be broadcast live on ESPN2. Fans can also follow the match live on ussoccer.com's MatchTracker, presented by Philips Electronics.


text:
(Use spaces to separate tags. Use single quotes (') for phrases.)
- With the BlueAnt Q2, not only can you now pair, configure and control your device with ease, but also make and receive calls using nothing but your voice.
- Managing incoming calls is as simple as saying "Answer" or "Ignore." Making outgoing calls is as simple as saying "Phone Commands." The BlueAnt Q2 will then activate your phone's voice dialing features.
- The BlueAnt Q2 automatically transfers a copy of your phone contacts after pairing, and can store up to 2,000 phonebook entries for each paired device. The Q2 can then use its integrated Text-to-Spech (TTS) engine to inform you of the incoming caller's name. You'll always know who is calling, without even having to pick up your phone.
- BlueAnt strived to create the best integration between its Q2 Smart Bluetooth Headset and your cellular phone. Through the use of an Android app (a free download), the BlueAnt Q2 is able to read out incoming text messages automatically. Learn more at the BlueAnt Android page.
- Made with compatibility in mind, BlackBerry and Android users may also install the VLingo SafeReader application. This application not only allows you to hear SMS messages, but also all of your emails.
- With the BlueAnt Q2 you can connect two phones to it at the same time. This means that if you have a business and personal phone, when either rings, you'll be able to take the call. Both phones remain connected at all time. If you have calls on both phones at the same time, you can even use the BlueAnt Q2 to switch between both calls. Think of it as call waiting on steroids.
Category | Bluetooth Headsets |
Manufacturer | BlueAnt |
Part Number | Q2 - Platinum |
Product Condition | New, Bulk Packaging |
Bluetooth Compliant | 2.1, A2DP, EDR |
Compatibility | compatible Bluetooth® enabled phones |
Talk Time | 5 Hrs |
Stand-by Time | 100 Hrs |
Features | Multipoint technology, Easy Pair |
Style / Fit | In-Ear Optional Ear-loop |
Connector Port | Micro USB |
Color | Platinum |
Package is Complete With: | BlueAnt Q2, Optional Ear Hook, Micro-USB Cable, Wall Charger, User Manual |


text:
CHARLESTON, W.Va. -- "Irresponsible, misleading" election ads are needlessly frightening West Virginia seniors, state Bureau of Senior Services staff members and seniors advocates say.
Federal health reform does not "gut" or even cut Medicare benefits as some ads claim, Marcia Meeks, director of the West Virginia State Health Insurance Program said this week. "Seniors actually get more benefits, starting in 2011."
"A lot of misinformation has been put out there during this election, and that's a shame," she said.
"There have been a lot of inaccurate, misleading things on the news and the Web," said Gaylene Miller, state AARP director.
"It's important for people to know that doctor visits, prescription drugs, outpatient visits, durable medical equipment, medical procedures, none of that will be cut back," Miller said. "It's also important for them to know about their new benefits."
For the past month, Bureau of Senior Services staff members, the AARP and other advocates have conducted informational sessions all over the state.
"A few days ago, seniors in Ceredo-Kenova told me TV ads were scaring them to death," Meeks said.
In addition to traditional benefits, Miller said, Medicare patients can now also get:
"There's a special place in hell for people who will scare senior citizens for partisan political purposes," Perry Bryant, director of West Virginians for Affordable Healthcare, said Thursday. "It's very troubling, because this law makes Medicare more secure than it's ever been.
"It's frustrating to see irresponsible, misleading political ads try to get seniors to vote against their own interests," he said.
Ads by the John Raese senatorial campaign and the Republican National Senatorial Committee "make it look like people's benefits are being cut, when actually it's fraud and overpayments being cut," he said.


text:
What is Ross NeverWet Spray? The video above says more about it than I could ever write into words.
LinkedIn Will Open Publishing Platform "Soon" to All Members http://t.co/KPymceAdMp cc @smallbiztrends #linkedin #publishers #expertise- Saturday Mar 8 - 12:58pm
Packaging lets consumers message the farmers that made their food http://t.co/wldK92lZl0 cc @springwise #consumer #beverages #qrcodes #food- Friday Mar 7 - 10:58am
Keep up with our news and developments
Share with your network


text:
It doubles as a portable tonearm complete with user replaceable needles. But it's totally manual so you have lift your head at the end of each record.
Mikey's Plugged In
No, that's not a hearing aid growing out of Michael Fremer's pinna—he's the official HE2006 spokesperson, so he has to keep his phone on 24/7. HE says he hasn't heard any truly balanced stereo soundstaging yet, for some reason.
Site Map / Direct Links
Loudspeakers Amplification Digital Sources | Analog Sources Accessories Featured | Music Columns Features | Show Reports | Show Reports |
Recommended Components Blogs Latest News Community |
Shop Resources Subscriptions |


text:
Baxter Area Rug
# 18702
* Free scatter rug with purchase of all braided rugs. See details>
Roll our Baxter Area Rug out and let this striped floor covering speak for itself. The bright, vibrant colors and hassle-free care of this indoor/outdoor rug make it perfect for kids' rooms or outdoor spaces.


text:
Dow Jones Local Media Group
Type | Subsidiary |
Industry | News media |
Founded | November 1936 |
Headquarters | Middletown, New York United States |
Products | Daily and weekly newspapers |
Employees | 1,500 |
Parent | Newcastle Investment Corp. |
Website | localmediagroupinc.com |
The Local Media Group, Inc. formerly Dow Jones Local Media Group, Inc. and Ottaway Newspapers Inc., is a subsidiary of Newcastle Investment Corp. and owns newspapers, Web sites and niche publications in California, Maine, Massachusetts, New Hampshire, New York, Oregon and Pennsylvania. It is headquartered in Middletown, New York, and its flagship is the Times Herald-Record. GateHouse Media, an affiliates of Fortress Investment Group along with Newcastle, is mann
The Ottaway organization was founded in by James H. Ottaway Sr., owner of the Endicott Daily Bulletin of Endicott, NY, in 1936. It had grown to nine newspapers in the northeastern United States by 1970, when it was acquired by Dow Jones & Company, publisher of The Wall Street Journal.[1]
Ottaway Newspapers[edit]
James H. Ottaway, Sr., founded the company in November 1936, when he purchased the Bulletin, a semi-weekly paper in Endicott, New York, that he converted to a daily within a year. Ottaway added the Oneonta Star in 1944, followed two years later by the Pocono Record.[1]
The company has been a seller more often than a buyer in the 2000s (decade), however, and several observers—including the New York Post, The Boston Globe and Ottaway's own Cape Cod Times—have speculated that News Corporation intends to sell all or part of the company in the near future.[2]
Dow Jones Local Media Group[edit]
Under Dow Jones' ownership, Ottaway sold several newspapers in recent years, however, most recently in December 2006, when the company dealt nearly half its daily newspapers to Community Newspaper Holdings Inc. (CNHI) for $287.9 million (including real estate).[3]
Until December 2006, the following dailies and weeklies were also part of the Ottaway chain. They are all now part of CNHI.[3]
- Santa Cruz Sentinel daily of Santa Cruz, California
- The News-Times daily of Danbury, Connecticut
- The Spectrum weekly of Milford, Connecticut
- Traverse City Record-Eagle daily of Traverse City, Michigan
- The Grand Traverse Herald weekly of Traverse City, Michigan
- Cooperstown Crier weekly of Cooperstown, New York
- Daily Star of Oneonta, New York
- Press-Republican of Plattsburgh, New York
- Daily Item of Sunbury, Pennsylvania
- The Danville News weekly of Danville, Pennsylvania
The following four daily newspapers were sold by Ottaway to CNHI for $182 million in 2002:[4]
- The Herald of Sharon, Pennsylvania
- The Independent of Ashland, Kentucky
- The Free Press of Mankato, Minnesota
- The Joplin Globe of Joplin, Missouri
Also, Ottaway sold the three daily newspapers of Essex County Newspapers Inc. to The Eagle-Tribune of North Andover, Massachusetts, in 2002, for $70 million.[5] The Eagle-Tribune, along with the Essex papers listed below, was later purchased by CNHI.
- Daily News of Newburyport of Newburyport, Massachusetts
- Gloucester Daily Times of Gloucester, Massachusetts
- Salem Evening News of Salem, Massachusetts
Local Media Group[edit]
On September 4, 2013, News Corp. announced that it would sell the Dow Jones Local Media Group to Newcastle Investment Corp.—an affiliate of Fortress Investment Group, for $87 million. The newspapers will be operated by GateHouse Media, a newspaper group owned by Fortress. News Corp. CEO and former Wall Street Journal editor Robert James Thomson indicated that the newspapers were "not strategically consistent with the emerging portfolio" of the company.[6] GateHouse in turn filed prepackaged Chapter 11 bankruptcy on September 27, 2013, to restructure its debt obligations in order to accommodate the acquisition.[7]
Holdings by frequency of publication[edit]
Dow Jones Local Media Group publishes eight daily and 15 weekly newspapers in seven U.S. states. Its circulation was given in 2005 as 282,000 daily, 316,000 Sunday and 119,000 daily unique visitors on newspaper Internet sites.[3]
Daily newspapers are:
- Ashland Daily Tidings of Ashland, Oregon
- Cape Cod Times of Barnstable, Massachusetts
- Mail Tribune of Medford, Oregon
- Pocono Record of Stroudsburg, Pennsylvania
- The Portsmouth Herald of Portsmouth, New Hampshire
- The Record of Stockton, California
- The Standard-Times of New Bedford, Massachusetts
- Times Herald-Record of Middletown, New York
Weekly and twice-weekly newspapers include the following:
- The Barnstable Patriot of Barnstable, Massachusetts
- The Inquirer & Mirror of Nantucket, Massachusetts
- Hathaway Publishing, published alongside The Standard-Times:
- Seacoast Media Group, published alongside The Portsmouth Herald:
- The Exeter News-Letter of Exeter, New Hampshire (twice-weekly)
- The Hampton Union of Hampton, New Hampshire (twice-weekly)
- The Rockingham News of Plaistow, New Hampshire
- York County Coast Star of Kennebunk, Maine
- The York Weekly of York, Maine
- Hudson Valley Media Group, published alongside the Times Herald-Record:
Holdings by location[edit]
- California
- The Record, Stockton, CA[8]
- Massachusetts
- The Advocate[8]
- Barnstable Patriot[8]
- Cape Cod Times[8]
- Cape Cod View[8]
- The Chronicle[8]
- The Fall River Spirit[8]
- The Inquirer and Mirror, Nantucket, MA[8]
- Middleboro Gazette[8]
- Nantucket Today[8]
- New England Business Bulletin[8]
- The Spectator[8]
- The Standard-Times, New Bedford, MA[8]
- New Hampshire
- The Exeter News-Letter[8]
- The Hampton Union[8]
- The Portsmouth Herald[8]
- York County Coast Star[8]
- The York Weekly[8]
- New York
- Limelight Deals, Middletown, NY[8]
- Marketing Blacksmith, Middletown, NY[8]
- Orange Magazine[8]
- Times Herald-Record, Middletown, NY[8]
- Oregon
- Pennsylvania
- Pocono Record, Stroudsburg, PA[8]
- ^ a b DowJones.com Community Media, accessed January 8, 2007.
- ^ "Ottaway Papers Might Be Sold, Including 16 in N.E.". NEPA Bulletin (Boston, Mass.), December 2007, page 3.
- ^ a b c "Dow Jones Completes Sale of Six Local Newspapers." Dow Jones & Company press release, December 5, 2006.
- ^ "Dow Jones To Sell Four Ottaway Newspapers", accessed January 8, 2007.
- ^ "Bay State Paper Gets to Grow in Its Own Backyard". NewsInc, April 22, 2002. Accessed January 8, 2006.
- ^ "News Corp. sells 33 papers to New York investors". New York Business Journal. Retrieved 4 September 2013.
- ^ http://www.bloomberg.com/news/2013-09-27/gatehouse-files-for-bankruptcy-as-part-of-fortress-plan.html
- ^ a b c d e f g h i j k l m n o p q r s t u v w x y z Dow Jones Local Media Group. "Locations". Retrieved 11 April 2012.


text:
An introduction to multicultural educationThis brief book is intended to provide readers with a succinct, comprehensive overview of multicultural education and what it means for classroom teaching. The book opens by describing the goals of multicultural education and misconceptions about it. Banks' five dimensions of multicultural education, discussed in Chapter 2, expose readers to the framework that is used in school districts across the country and is widely reprinted in educational publications. |
What people are saying - Write a review
Review: An Introduction to Multicultural Education
User Review - Danielle - GoodreadsI read this for a class as I was getting my ELL endorsement. It has some interesting information, but it is beneficial to talk with someone about it to digest the information. Read full review
Review: An Introduction to Multicultural Education
User Review - GoodreadsI read this for my foundations in education class.
Related books
Multicultural Education: Issues and Perspectives James A. Banks,Cherry A. McGee Banks Limited preview - 2009 |
2j Dimensions and School Characteristics | 13 |
Curriculum Transformation | 21 |
School Reform and Intergroup Education | 35 |
Copyright | |
8 other sections not shown
Common terms and phrases
academic achievement African Americans Afrocentric American exceptionalism American Revolution American students Anglo Arawaks Asian Americans behavior challenge chapter characteristics Chief Illiniwek citizens citizenship education civic classroom colleges Columbus communities create CROCCO cultural and ethnic cultural diversity cultural groups democratic dents describes effective ethnic and cultural ethnic diversity ethnic groups experiences Garcia gender global identifications goal of multicultural help students Hispanic identity implement important institutionalized key concepts language Latinos low-income students mainstream metanarrative Mexican American movement multicul multicultural curriculum multicultural education multicultural school nation-state nation's schools Native Americans paradigm participate percent perspectives positive racial attitudes race racial and ethnic racial groups racism reflect reform restructuring Revolution school culture school districts skills needed social-class groups students from diverse students of color teacher education teaching strategies tion transformative tural tural education U.S. Census Bureau U.S. society understand United University unum values White


text:
Via Co.Design
This seems like something the Apple TV could provide fairly easily.
(via mikehudack)
The official Tumblr of Fast Company.
This is where I want to be in the future. Helping redefine entertainment experiences…
Technology absolutely amazes me. I can't make any of these cool things, but I sure can appreciate them.
When?! When will this happen?
Damn…why didn't I think of this? -JMT
Jamie Oliver es un crack #WIN


text:
Sonic the Hedgehog Spinball
Talk12this wiki
Sonic the Hedgehog Spinball | |
Developer(s) |
Polygames, Sega Technical Institute, Sega interactive Development Devision (8-bit version) |
Publishers(s) | |
Release date(s) |
Mega Drive/Genesis |
Genre(s) |
Action, Pinball |
Mode(s) |
Single-player, Multiplayer |
Rating(s) |
VRC: General Audiences (GA) |
Platform(s) |
Genesis, Game Gear, Master System, Virtual Console, PlayStation 2, Nintendo Gamecube, Xbox, PC, Game Boy Advance, iOS devices |
Media |
Cartridge |
Input |
Control pad |
Sonic the Hedgehog Spinball, also known as Sonic Spinball (ソニックスピンボール Sonikku Supinbōru?), is the first adventure/pinball game released for the Sonic the Hedgehog series. It was originally released for the Sega Mega Drive/Genesis in 1993 and later ported to the Game Gear system.
It was also released in 1995 on the Master System in Europe by Sega Europe (which is one of the last games released in Europe for the system and is quite hard to find), and was later released in Brazil by TecToy and in Portugal by Ecofilmes. This version is a port of the Game Gear version.
The Mega Drive/Genesis version was released on the Wii's Virtual Console on 12 March 2007 in North America and 5 April 2007 in Europe, and also appears on the Sonic Mega Collection compilation for Nintendo GameCube, PlayStation 2, Xbox and PC. The Game Gear version also appears as an unlockable minigame in Sonic Adventure DX: Director's Cut for the GameCube and PC, as well as Sonic Gems Collection for the Nintendo Gamecube and the PlayStation 2.
The game title is a pun on pinball and Sonic's famous spin move. It is the only Sonic game to feature characters from the Saturday morning cartoon Sonic the Hedgehog and Adventures of Sonic the Hedgehog, other than Dr. Robotnik's Mean Bean Machine. The game's musical score was composed by Howard Drossin.
Sonic Spinball is essentially the logical continuation of a tradition of pinball themed levels that started with Spring Yard Zone on Sonic the Hedgehog. The game features four large pinball 'tables'—a sewer level, a geothermal power station, a badnik factory, and a launchpad system. The player must guide Sonic through each of the four levels and collect all of the Chaos Emeralds, then fight Dr. Robotnik.
The main difference between this game and an actual pinball game is the ability to influence the "ball" (Sonic) directly by using the D-pad. The A, B and C buttons operate the flippers and can be assigned in the Options menu. Sometimes the player can control Sonic on foot, but for the majority of the time he is rolled into a ball controlled by the flippers. The traditional Sonic the Hedgehog platformer gameplay is kept to a minimum.
Dr. Robotnik has assumed control of Mt. Mobius and turned it into a mechanical base. Utilizing energy produced by the magma flowing under the volcano, this new monstrosity base (the Veg-O-Fortress) has the power to transform helpless animals into robot slaves at an astounding rate. Sonic the Hedgehog and Miles "Tails" Prower fly onto the scene to mount an aerial assault, but Sonic is knocked off the wings of Tails' airplane by a blast from the fortress (in the 8-bit version, he intentionally drops down instead). He falls into the water, but is rescued and taken to the subterranean levels of the Veg-O-Fortress. The fortress must be destroyed from the inside-out, and the only way to make that happen is to trigger an eruption in the volcano it's built on. Sonic knows this can be done by removing the Chaos Emeralds that keep the volcano stable. Robotnik, however, is also aware of the fragile relationship that exists between the Emeralds and the mountain, and he has established an elaborate Pinball Defense System to make sure the precious jewels don't go anywhere.
- Toxic Caves: Sonic is flushed into a stinky cavern full of toxic sludge and mine carts, which just so happens to be the place where Robotnik dumps all of the industrial waste. There are three Chaos Emeralds to collect here that must be obtained by hitting multiple switches. In 8-bit versions, it is known as Toxic Pools with a completely different layout design - though the remaining levels retain simplified versions of their Genesis boards.
- Lava Powerhouse: Sonic ascends to the next level, a power station of sorts that uses magma and steam energy to run various machines. There are three emeralds here.
- The Machine: There are five emeralds here in this high-tech level. Sonic can also find a giant-sized animal prison in the very middle of this zone.
- Showdown: Sonic has to find five emeralds and reach the top of the Launch site to defeat Dr. Robotnik before he manages to escape.
Bonus Stages
At the end of each of the first three stages, Sonic gets to play a bonus round. Although it is not a true Special Stage, these bonus rounds are set up like real pinball machines, with Sonic at the controls. The player is given a task to complete and three balls to play with. Flipper controls are the same as in the normal game, but the ball cannot be controlled with the D-pad like Sonic. Pressing all the flipper buttons at once will make Sonic shake the machine, though repeated shakes will cause a 'tilt' and lock the flippers.
Completing the bonus stages are optional and serves only to increase the player's score. The three bonus rounds, in corresponding order to the normal zones, are:
- Trapped Alive: The object is to destroy all the robot machines and free the helpless animals trapped inside them and then destroy Robotnik. Among the prisoners are Sonic's Freedom Fighter pals from the SatAM cartoon and Archie comic: Bunnie Rabbot, Sally Acorn, Muttski and Rotor. Also imprisoned are Tails, a gray Flicky and Wocky.
- Robo Smile: A grinning Robotnik face moves across the machine. The objective is to knock out all of Robotnik's teeth.
- The March: Similar to Trapped Alive, the object is to destroy the capsule and free the animals and Freedom Fighters within. The capsule is circled by a ring of Scratch robots.
- The Clucker's Defense: An additional, a hidden multi-ball bonus game, Clucker's Defense can be played on any stage, but only if the player manages to collect every ring in the zone. Several star circles will appear in the stage, hidden at various points on the board. By leaping into them Sonic will be warped to this bonus round. The object is to destroy a Crawl badnik who is protected by a pair of Cluckbirds.
The 8-bit versions of this game feature only one unnamed Bonus Stage, which has Sonic on a 2D plane collecting rings and power-ups (such as lives) in a time limit.
The Archie Sonic the Hedgehog comics made an adaptation of this game in Sonic the Hedgehog #6. The story covered the first two levels of the game and introduced Hip and Hop in the comics for the first time.
In the episode "Attack on the Pinball Fortress" in Adventures of Sonic the Hedgehog, Dr. Robotnik has a fortress where the inside is like a giant pinball machine, much like the fortress where this game takes place. In the episode "Robotnikland" Sonic hops into a pinball machine and faces off against Robotnik to see who can get more points with Sonic acting as the ball.
There's loose reference to the game in episode Game Guy of Sonic the Hedgehog animated series, where Dr. Robotnik traps Sonic in a giant pinball machine and uses Sonic as the ball. Much like the Adventures of Sonic the Hedgehog episode, "Robotnikland", Sonic and Robotnik face off in to see who can earn more points both using Sonic as the ball.
Alton Towers
Alton Towers is a theme park and resort located in Staffordshire, England. It attracts around 2.8 million visitors per year, making it the most visited theme park in the United Kingdom. In February 2010, a new Sonic attraction by the same name of this game opened.
Logos and Artwork
Gallery |
Box Arts
16-Bit Version
Gallery |
8-Bit Version
Gallery |
Gallery |
- The total Chaos Emerald count in Sonic Spinball is sixteen as opposed to the standard set of seven, and they are all the same color - blue. It is possible that Sonic is collecting the same three/five Chaos Emeralds that appear in each level. It is also very likely that this before the max number of Chaos Emeralds was determined in the series' mythos.
- The third level, The Machine, is based on a scrapped Zone, Genocide City Zone, from Sonic the Hedgehog 2.
- The Game Gear and Master System artwork shows Dr. Robotnik from Adventures of Sonic the Hedgehog.
- This marks the first and currently only appearance of the characters from SatAM in a Sonic game, and the first attempt to introduce them to Japanese markets.
- This game and Dr. Robotnik's Mean Bean Machine are the only Sega Genesis games that have an actual counterpart on the Game Gear and Master System.
External links
Sonic the Hedgehog Spinball | |||
Characters | Sonic | Tails | Dr. Robotnik | Flicky | Cucky | Locky | Wocky | Sally* | Bunny* | Rotor* | Muttski* | Hip and Hop* | ||
Stages | Toxic Caves/Toxic Pools | Lava Powerhouse | The Machine | The Showdown/Final Showdown | Bonus Stages | ||
Enemies | Magma Worm | Cluckbird | Rexxon | Ferron | Buster | Krondor | Scratch* | Clucker | Crawl | Buzz Bomber | ||
Bosses | Scorpius/Toxic Pools Boss | Robo-Boiler | Veg-O Machine | Robotnik's Ship/Final Showdown Boss | ||
Other | Balloon | Bumper | Chaos Emeralds | Drop Target | Flipper | Minecart | Mobius | Mount Mobius | Pinball Shooter | Rings | Sewer Warp | Drain Bumper | Sonic the Hedgehog Boom | Spin Jump | Super Spin Dash | Tornado | Transport Tube | Veg-O-Fortress
*Cameo appearance in 16-bit version of the game. |


text:
$8.99 flat-rate shipping per item inside continental (48) United States. Surcharge applies to AK/HI/PR and international destinations.
Ease up on your next outdoor cleanup
The WORX TRIVAC ™ 3-in-1 compact blower/mulcher/vacuum brings all three functions together in one compact, lightweight machine: a great blower... a handy mulcher... and a powerful yard vac!
As a blower, the TRIVAC ™ produces an airspeed of over 210 mph, strong enough for even the toughest wet leaves and debris.
While vacuuming, the high impact resistant impeller mulches leaves up to 1/10 of their original size.
When in vacuum mode, the powerful motor in the TRIVAC ™ generates 350 cubic feet of airflow per minute.
Compact and Lightweight
The compact and lightweight size of the TRIVAC ™ is specifically designed for extended use with only one hand.
Clean with ease
The quick release button located on the top of the tool makes it easy to cleanup debris.
Escape the hassles
No more oil and gas. Plug in and enjoy the power and convenience provided by the TRIVAC ™.
Brand | Worx |
Part/Model Number | WG500 |
Condition | New |
Voltage | 120V~60Hz |
Power Input | 12 amp |
Max. Air Speed | 210 mph |
Max. Air Volume | 350 cfm |
Collection Bag Capacity | 1.5 bushels |
Mulch Ratio | 10:1 |
Machine Weight | 8.4 lbs. |
3-in-1 Blow/Mulch/Vac | Yes |
Blow-to-Vac Switch (No Tools) | Yes |
One Hand Operation | Yes |
Compact & Lightweight | Yes |
Chisel Nose for Tight Areas | Yes |
Easy Clean System | Yes |
Metal Impeller | No |
2-Stage Mulching System | No |


text:
November Campaign
An Evening with the Stars
Become an Advocate
Corporate Champions
Social Media
Vision of Progress
Volunteer Stories
One on One Support
Recently Diagnosed
Learn About Pancreatic Cancer
Clinical Trials
Treatment Options
Find Support Resources
Survivor Stories
Educational Events
Free Educational Packet
For Health Professionals & Researchers
Strategic Research Program
Research Grants
Scientific Progress
Resources for Scientists
Submit Clinical Trial Info
Research in the News
Scientific & Medical Advisors
Researcher Stories
Become an Advocate
Sign Up for News & Advocacy Alerts
Advocacy Day
Learn Our Issues
Fact Sheets & Reports
Advocacy Action Center
Congressional Update
Advocacy Stories
2020 Goal/Vision of Progress
Mission & Goals
Programs & Services
Financial Information
Leadership Teams
Celebrity Circle
Press Center
Video Library
Contact Us
Donate Now
How Your Donation Works
Ways to Give
Visionary Circle
Shop Purple
Cards with a Heart:
Flowers That Give Back
En Español
Adjust Text Size:
See All Stories
Researcher Story: Ru Chen, PhD
I started to realize that cancer was a very serious word when I was a child. My mom was then a physician, so I had heard firsthand about how devastating this disease was. Through the inspiration and encouragement of my mom, I was determined to become a researcher to work on how to cure cancer ever since my childhood,
My early dream became a reality after I moved to the United States for graduate school. I chose to study colon cancer as my graduate research project. After I finished my graduate work, I focused my post-doctoral research on pancreatic cancer because I was inspired by my mentor, Dr. Teresa Brentnall. For years, Dr. Brentnall has been deeply involved in the care of pancreatic cancer patients in Seattle, Washington, as well as research aimed at improving earlier detection and diagnosis of the disease.
A few years ago, after I finished my post-doctoral training, I applied for a grant to support my pancreatic cancer research. For people like myself, who are just finishing their post-doctoral training, usually the first grant is the most difficult to obtain, because you have not yet established your credentials.
At this critical time, I received a Pancreatic Cancer Action Network Career Development Award to initiate a project searching for biomarkers for early detection of pancreatic cancer. With this grant, I was able to carry out a pilot study, and generate convincing data and publications that eventually led to five years of follow-up funding from the National Institutes of Health (NIH).
Although the NIH is the main resource for providing cancer scientists with research funding, private funds raised through the Pancreatic Cancer Action Network are very important to support research into pancreatic cancer in a unique way. This organization is especially focused on providing grants to foster early-career researchers in pancreatic cancer and providing support for innovative projects.
Receiving a diagnosis of pancreatic cancer is perhaps one of the hardest things a person could ever face. If I were in this situation, I would allow myself to grieve over this for a few days. But I would need to get back to reality after that. It is important to be positive in the fight against this disease. Moreover, if you are proactive, you would know that there are a lot of things that you could do to improve the lives of yourself and your loved ones after the diagnosis. Things like learning more about pancreatic cancer, exploring treatment options and seeking support groups can be very helpful.
More importantly, keep your hopes up. You are not fighting this disease alone. Many caregivers, doctors, researchers and supporters are also fighting along with you in different ways you may not realize.
2006 Pancreatic Cancer Action Network – AACR Career Development Award
Ru Chen, PhD, University of Washington, Seattle
Biomarkers for Early Detection of Pancreatic Cancer
See All Stories
1500 Rosecrans Avenue, Suite 200, Manhattan Beach, CA 90266
Toll Free: 877-272-6226 | Phone: 310-725-0025 | Fax: 310-725-0029
Share This Site
Donate Now
Contact Us
Site Map
Privacy Policy
Job Listings
Site Problems
Join Our Mailing List
Our 9th Consecutive Year.
Honors the Pancreatic Cancer Action Network as
ranking in the top ten of outstanding charities.
© 2014 Pancreatic Cancer Action Network
PANCAN®, PURPLESTRIDE®, PURPLERIDE® PURPLEBOWL®, TEAMHOPE® and
PANCREATIC CANCER ACTION NETWORK® are registered trademarks.


text:
Copyright © 2008 Elsevier Ltd All rights reserved.
Current Biology, Volume 18, Issue 17, R751-R753, 9 September 2008
Guest editorial
Add/View Comments (0)Biological rhythms: Clocks for all times
Main Text
The development and harmonious functioning of an organism depend on the exquisite coordination of myriad intertwined biological processes. As illustrated by this issue of Current Biology devoted to the 'biology of time', temporal organization plays crucial roles in coordinating dynamic phenomena as diverse as progression through the cell cycle, the processing of information, adaptation to the periodic environment, and the response to extracellular or intracellular signals. Here I will focus on one of the most conspicuous manifestations of temporal organization, that which takes the form of rhythmic behavior.
If rhythms did not exist, would we see the passage of time? The alternation of day and night, and the cycle of the seasons remind us that life's environment is inherently periodic. Life itself is rhythmic: from the periodic generation of action potentials in neurons or cardiac cells to the cell division cycle and circadian rhythms, many key cellular processes possess a repetitive, oscillatory nature. Rhythmic behavior also occurs at the supracellular level, as exemplified by the ovarian cycle and by annual rhythms such as flowering, migration, hibernation or reproduction in some mammalian species. The period of biological rhythms spans more than ten orders of magnitude, from a fraction of a second up to tens of years (see Table 1).
Table 1 |
Biological rhythm | Period | ||
Neural rhythms∗ | 0.001 to 10 seconds | ||
Cardiac rhythm∗ | 1 second | ||
Calcium oscillations∗ | Seconds to minutes | ||
Biochemical oscillations∗ | 30 seconds to 20 minutes | ||
Mitotic oscillator∗ | 10 minutes to 30 hours | ||
Segmentation clock∗ | 30 minutes to 2 hours | ||
Hormonal rhythms∗ | 10 minutes to 3–5 hours (also 24 hours) | ||
Circadian rhythms∗ | About 24 hours | ||
Ovarian cycle | 28 days (menstrual cycle) | ||
Annual rhythms | 1 year | ||
Rhythms in ecology and epidemiology | Years | ||
∗ These rhythms can already occur at the cellular level. |
Why are there so many biological rhythms? The answer is: regulation. Cellular regulatory processes are multifarious and can all give rise to oscillations [1]. Thus, activation and inhibition of ionic conductances as a function of the membrane potential combine to produce periodic behavior in electrically excitable cells. The regulation of enzyme activity underlies metabolic oscillations, while control of transport between different intracellular compartments gives rise to oscillations of cytosolic Ca2+. Regulation of gene expression is involved in the origin of circadian rhythms and of the segmentation clock that controls somitogenesis.
A common property of regulatory feedback loops is their capability of inducing instabilities. Of relevance to rhythmic behavior is the situation where the regulated system undergoes sustained oscillations around a steady state that has become unstable beyond a critical value of some control parameter or in a parameter range bounded by two critical values [1,2]. For example, intracellular Ca2+ oscillations occur in many cell types subjected to intermediate levels of hormonal stimulation. Below a critical value of stimulus intensity, the level of Ca2+ stabilizes at a low constant level, while above a second, higher critical value, cytosolic Ca2+ reaches a high steady-state level. Likewise sustained oscillations occur in glycolysing yeast extracts in a range bounded by two critical values of the substrate input rate. Because they occur beyond a critical point of instability of a nonequilibrium steady state, biological rhythms can be viewed as temporal dissipative structures [3].
A flurry of cellular rhythms have been discovered during the last decade. Among these is the segmentation clock which controls the periodic formation of somites in vertebrate development. This system is of particular interest because of its key role in embryogenesis and the fact that it records a temporal structure as a permanent pattern of spatial organization [4]. The clock is also expressed in cell cultures in the form of oscillatory transcription of the gene Hes1[5]. Other recently observed rhythms include oscillations in both the tumor suppressor p53 [6] and the transcription factor NFκB [7], stress-induced oscillations in the nucleocytoplasmic shuttling of the transcription factor Msn2 in yeast [8], and the periodic organization of the yeast transcriptome [9].
Because rhythmic behavior cannot be ascribed to a single gene or enzyme, and rather constitutes a systemic property originating from regulatory interactions between coupled elements in a metabolic or genetic network, cellular rhythms represent a prototypic field of research in systems biology. Models help unraveling the dynamics of cellular rhythms and show that sustained oscillatory behavior often corresponds, in the concentration space, to the evolution toward a closed curve known as a limit cycle. Cycling once around this trajectory takes exactly one period. The closed trajectory is generally unique in a given set of conditions, and is particularly stable as it can be reached regardless of initial conditions. The limit cycle is a central figure in the study of biological rhythms [1,2].
The major questions regarding cellular rhythms pertain to their molecular mechanism and to their physiological function. With regard to mechanism, an oscillation can be divided into a succession of phases: understanding the mechanism of the rhythm amounts to clarifying how one phase brings about the next one, and why the process is repetitive — why the first phase is necessarily induced by the last phase of the preceding cycle. This analysis is facilitated by the use of models that present the advantage of allowing us to freeze the behavior of an oscillatory system at any given moment over the period, so as to clarify the relationships between the variables and the process that predominates at any particular phase of the cycle.
The molecular bases of periodic behavior have been particularly well studied in the case of circadian rhythms. In eukaryotic organisms, these rhythms appear to originate from indirect, negative autoregulation of gene expression (see [10] and the reviews devoted to circadian rhythms in this issue). The mechanism of the circadian clock differs in cyanobacteria, where it involves a cyclical process of protein phosphorylation [11]. The segmentation clock involves a network of coupled signaling pathways, each of which appears to be capable of oscillations likely due to negative feedback [12,13]. Negative regulation can be mediated by repression of gene transcription, activation of protein degradation, or inhibition of a kinase or phosphatase in a signaling pathway through reversible phosphorylation. Negative feedback on transcription is also at the core of the 'repressilator', a synthetic gene oscillatory network based on three cyclically coupled repressors [14].
Although all biological rhythms reflect a process of temporal self-organization, some do not serve directly to measure the passage of time. Thus, rhythms that link the periodic generation of action potentials to muscular movement underlie the periodic operation of physiological machines: the cardiac rhythm ensures the periodic contraction of the heart, while oscillatory neural networks known as central pattern generators drive the rhythms of locomotion and respiration. Many biological rhythms, however, do have a function associated with the measure of time. Adaptation to the periodic nature of the terrestrial environment is the role of the circadian clock and of annual rhythms. Thus, oscillations of 24-hour period allow the organisms to adapt to and anticipate the alternation of day and night. Likewise annual rhythms underlie adaptation to the cycle of the seasons. The circadian clock and seasonal rhythms provide the strongest links between biological periodicities and time.
Circadian and annual rhythms are often closely intertwined, as shown by the example of flowering: the annual rhythmic variation of the photoperiod — which measures the duration of the light phase over 24 hours — controls the phase of the plant circadian clock. The expression of genes leading to flowering is triggered when the circadian peak in a particular protein coincides with the light phase. Another example of the close link between the circadian and annual clocks is given by the migratory behavior of the Monarch butterfly. Elegant experiments have shown that the butterfly uses the phase of its circadian clock to select orientation during flight [15].
The link between biological rhythms and time can take additional forms. An important function of oscillations is to allow for the frequency encoding of pulsatile signals in intercellular communication. One of the most striking examples is given by the pulsatile secretion of gonadotropin-releasing hormone (GnRH). This hormone is released by the hypothalamus with a frequency of one pulse per hour. The frequency of the hormone governs its physiological efficiency: a less or more frequent pulsatile release fails to elicit the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the pituitary at levels required for ovulation [16]. Such a frequency encoding of the pulsatile signal is also observed for intercellular communication by pulses of cyclic AMP in Dictyostelium amoebae. In this case, as in the case of GnRH, receptor desensitization under constant stimulation provides a basis for the frequency encoding of the pulsatile signal. The kinetics of receptor desensitization and resensitization determine the optimal frequency that ensures maximum target cell responsiveness [1]. A similar explanation holds for growth hormone signaling, which proves more efficient when delivered in pulses at the optimal frequency rather than in a continuous manner.
Frequency encoding is also encountered for intracellular pulsatile signaling, as observed for oscillations of cytosolic Ca2+. The waveform and frequency of Ca2+ signals can exert profound effects on gene expression, and can thereby modulate neuronal differentiation [17]. One mechanism for encoding of Ca2+ spikes relies on the control of Ca2+-activated enzymes such as CaM-Kinase II [18]. Signaling in the brain is also based on the frequency of trains of action potentials, which can be modulated by the intensity of neuronal stimulation [19]. The oscillatory activity of neurons appears to play a central role not only in transducing sensory responses but also in the neurobiology of consciousness.
Physiological disorders may arise from a mismatch between internal biological time and environmental cues. The clearest case pertains to the sleep–wake cycle. Hypophosphorylation of PER2, one of the major actors in the circadian clock mechanism, shortens the autonomous period of the clock and leads to a phase advance of several hours with respect to the natural light–dark cycle [20]. This alteration of circadian oscillations underlies the familial sleep phase advance syndrome (FASPS). Lack of entrainment can also occur, in the form of the non-24 hour sleep–wake syndrome by which the sleep-wake cycle runs at its own free-running period, unconnected with the light–dark cycle. Mood disorders also appear to be related to circadian rhythms [21] and may further possess an annual component, as reflected by seasonal affective disorders. Disorders related to dysfunctions of ultradian cellular oscillations are also known. Among these are syndromes associated with the absence of Ca2+ oscillations or waves, and cases of sterility resulting from alterations in the pulsatile secretion of the hormone GnRH.
The cell cycle itself may be viewed as a cellular rhythm, not only in the case of early cycles in frog embryos but also in more complex cell cycles subjected to checkpoints in somatic cells. Such a view leads to considering cancer as a dysfunction of normal cyclical or non-cyclical behavior of the biochemical machinery controlling cell proliferation. Cross-talk between different rhythms is illustrated by the link between the cell cycle and the circadian clock [22]. The latter controls the expression of the kinase wee1, thereby inhibiting in a circadian manner the kinase Cdk1 and, hence, the G2/M transition.
From a clinical perspective, the relationship between rhythms and time in biological systems bears on the appropriate timing of medications. Experimental and clinical evidence shows that the circadian administration of anticancer drugs at the right time of the day can prove more efficient against tumor cells while minimizing damage to host tissues. Such chronotherapeutical approaches are based on the observation that many cellular processes, including those controlling cell proliferation or the activity of drug-degrading enzymes, vary in a circadian manner [23].
The ubiquity and physiological significance of biological rhythms can be illustrated by one last example, which shows how rhythms are often nested in a manner reminiscent of Russian dolls. In the process of reproduction, several rhythms play key roles at different stages and with markedly distinct periods. Fertilization of an egg triggers a train of Ca2+ spikes that are essential for successful initiation of development. Prior to these Ca2+ oscillations of a period of the order of minutes, ovulation requires appropriate levels of LH and FSH established through pulsatile signaling by GnRH with a period close to one hour (the response of pituitary cells to GnRH also involves high-frequency Ca2+ oscillations). The ovulation cycle is itself periodic, and takes the form of the menstrual cycle in the human female. Capping these various periodicities, in many animal species reproductive activity varies according to an annual rhythm controlled by the photoperiod, through modulation of the circadian secretion of melatonin [24]. In a final manifestation of the ticking of the biological clock, ovulation stops at menopause. At the very core of life, the reproductive process highlights the deeply rooted links between rhythms and time in biological systems.
1 (1996). Biochemical Oscillations and Cellular Rhythms. (Cambridge, UK: Cambridge University Press). PubMed
2 (2002). Computational approaches to cellular rhythms. Nature 420, 238–245. CrossRef | PubMed
3 (2007). Biological rhythms as temporal dissipative structures. Adv. Chem. Phys. 135, 253–295. PubMed
4 (2003). The segmentation clock: Converting embryonic time into spatial pattern. Science 301, 328–330. CrossRef | PubMed
5 (2002). Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science 298, 840–843. CrossRef | PubMed
6 (2004). Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat. Genet. 36, 147–150. CrossRef | PubMed
7 (2002). The IkappaB-NF-kappaB signaling module: Temporal control and selective gene activation. Science 298, 1241–1245. CrossRef | PubMed
8 (2007). Nucleocytoplasmic oscillations of the yeast transcription factor Msn2: evidence for periodic PKA activation. Curr. Biol. 17, 1044–1049. Abstract | Full Text | PDF (701 kb) | CrossRef | PubMed
9 (2007). Cyclic changes in metabolic state during the life of a yeast cell. Proc. Natl. Acad. Sci. USA 104, 16886–16891. CrossRef | PubMed
10 (2002). Coordination of circadian timing in mammals. Nature 418, 935–941. CrossRef | PubMed
11 (2005). Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro. Science 308, 414–415. CrossRef | PubMed
12 (2006). A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science 314, 1595–1598. CrossRef | PubMed
13 (2008). Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways. J. Theor. Biol. 252, 574–585. CrossRef | PubMed
14 (2000). A synthetic oscillatory network of transcriptional regulators. Nature 403, 335–338. CrossRef | PubMed
15 (2003). Illuminating the circadian clock in Monarch butterfly migration. Science 300, 1303–1305. CrossRef | PubMed
16 (1978). Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone. Science 202, 631–633. PubMed
17 (2000). Coding of neuronal differentiation by calcium transients. BioEssays 22, 811–817. CrossRef | PubMed
18 (1998). Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations. Science 279, 227–230. CrossRef | PubMed
19 In Temporal Coding in the Brain. Buzsaki, G., Llinas, R., Singer, W., Berthoz, A., Christen, Y., eds. (Berlin: Springer). PubMed
20 (2001). An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 291, 1040–1043. CrossRef | PubMed
21 (2007). Circadian genes, rhythms and the biology of mood disorders. Pharmacol. Ther. 114, 222–232. CrossRef | PubMed
22 (2003). Control mechanism of the circadian clock for timing of cell division in vivo. Science 302, 255–259. CrossRef | PubMed
23 (2007). Circadian rhythms: mechanisms and therapeutic implications Annu. Rev. Pharmacol. Toxicol. 47, 593–628. PubMed
24 (2001). Biology of mammalian photoperiodism and the critical role of the pineal gland and melatonin. J. Biol. Rhythms. 16, 336–347. CrossRef | PubMed


text:
A Midsummer Night's DreamThursday - Saturday, February 25- February 27, 2010 at 7:30 p.m.Sunday, February 28, 2010 at 2:00 p.m.Classic Romantic Comedy A romantic comedy that portrays the adventures of four young Athenian lovers and a group of amateur actors, their interactions with the Duke of Athens, Theseus, the Queen of the Amazons, Hippolyta, and with the fairies who inhabit a moonlit forest. The play is one of Shakespeare's most popular works for the stage and is widely performed across the world. This production counts toward forum requirements. By: William ShakespeareDirection by: Deborah MogfordClark Arts Center, Maddox TheatreSee the Maddox Seating Chart(.pdf) for this performance. Tickets: Adults $10, Seniors $7, Students $7
3/6/2014 » 3/27/2014NICNE Certificate in Nonprofit Management - Course 4
3/15/2014Naples Alumni Gathering
3/19/2014PYSK Talks: Bob Trojan
3/21/2014 » 4/25/2014Jeremy Long: Personal Allegories
3/21/2014Jeremy Long: Personal Allegories; artist lecture and reception
23 hours agoJeremy Long: Personal Allegories art exhibit to open March 21 at Rockford University
3/11/2014Corporate responsibility focus of 6th annual Business Luncheon
3/7/2014University provides $118 million annual impact on regional economy
3/3/2014Regents Golf Coach Lloyd McWilliams Earns National Recognition
2/27/2014Rockford University to celebrate the 167th year of its founding


text:
Village Picnic Pavilion
The Village Picnic Pavilion overlooks the main entrance to the Zoo, is surrounded by greenery, and offers a private setting for your group. Situated conveniently near concessions and restrooms, this pavilion can be used by your group throughout the day.
Maximum Number of Guests
Year Round
(daytime only)
Rental Rate
$200 for a full day*
*Discounted group admission rates apply
All animal exhibits close at dusk
For reservations, call 412-365-2536
For catering information, call our own
"Taste of the Wild Catering" at 412-365-6003.