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Latest Headlines
Counties in the Winter Weather advisory until 10 a.m. Friday include: Dawson, ...
UPDATE: Police say the boy was found safe around 10:30 p.m. Thursday evening ...
Friday marks the sixth annual National Dress in Blue Day, which is geared ...
Tempe, AZ (SportsNetwork.com) - The Los Angeles Dodgers and Los Angeles Angels ...
Scottsdale, AZ (SportsNetwork.com) - The Oakland Athletics and Arizona ...
Surprise, AZ (SportsNetwork.com) - The White Sox scored twice in the top of ...
Hands On Atlanta helps individuals, families, corporate and community groups ...
11Alive News personalities show fraternal/sororal allegiance
The 30th annual Hunger Walk/Run takes place Sunday, March 9, 2014 at Turner ...
Video: Atlanta Labor Day Tour
Video: Avoid "perfect storm" of traffic this weekend
ATLANTA -- You've been warned: the perfect storm of traffic congestion is brewing in Atlanta this coming Labor Day weekend.
Those trying to travel out of town for the holiday will run into a lot of extra drivers on the road. Conservative crowd estimates place an extra half a million people in the area for several different events.
The Atlanta Convention and Visitors Bureau said those tourists will have an impact in excess of $70 million on the local economy.
Here are the numbers:
• Two football games at the Dome will draw 144,000 fans. • Four home Braves games will draw about 140,000 fans. • The Dragon Con sci-fi convention is expecting record attendance at 50,000. • 104.7 The Fish's Celebrate Freedom Concert expects up to 60,000 attendees. • The Decatur Book Festival and Black Gay Pride events are each planning for crowds of 70,000 people. • The Atlanta Motor Speedway in Hampton is expecting 100,000 people at events throughout the weekend, including a Sunday night race.
A traffic consultant told the Atlanta Business Chronicle Atlanta's congestion will be the 9th worst in the nation this weekend. So if you need to travel through town, and can't avoid the city's traffic, there are a few safe windows.
Try to leave after lunch on Friday to avoid the evening rush hour crowds. Friday night at 7:30, a Braves game and college football game will start at the same time. You'll have to wait until after dark to avoid the major congestion.
If you want to wait until Saturday to leave, go as early as possible in the morning. Traffic will pick up again at noon, with more sports events Saturday afternoon and evening.
11Alive will be covering the events all Labor Day weekend long, and providing you the latest information on travel.
If you are attending any events we'd love to see your pictures. Send them to us at email@example.com.
Here are some of the big events and resources to help plan your weekend.
Dragoncon It's one of the biggest Sci-Fi events in the country. 11Alive will be covering the events on our Downtown Where You Live website. For more information on the Dragoncon events click here.
Atlanta Black Pride Weekend http://www.atlantaprideweekend.com/index.html
Braves http://atlanta.braves.mlb.com/index.jsp?c_id=atl&sv=1
Chick-fil-A college football kick-off games http://www.chick-fil-akickoffgame.com/
Celebrate Freedom Concert http://www.celebratefreedomatlanta.com/ The region's largest free one-day concert takes place at Marietta's Jim Miller Park Saturday. For more Marietta news, visit our Where You Live Marietta Community Site.
UGA first home game http://www.georgiadogs.com/sports/m-footbl/geo-m-footbl-body.html
NASCAR at Atlanta Motor Speedway http://www.atlantamotorspeedway.com/
Decatur Book Festival http://www.decaturbookfestival.com/2012/schedule/index.php See more Decatur news on 11Alive's Where You Live Decatur Community Site.
RELATED | Latest traffic information EVENT CALENDAR | This weekend's other events


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You don't pay for tutoring unless you find a good fit!
I understand that so many times, what separates exceptional students from other students isn't intelligence or aptitude, but the passion to learn. It has been my life's work to help others to gain that desire by meeting them at their level, and helping them with the way forward to success. I have always loved teaching in many different capacities. From college age on, I have tutored young people on many different subjects ranging from math to music. For over 20 years, I have instructed pilot candidates on how to operate jet aircraft. As a personal trainer, I have helped educate and motivate people to achieve optimum fitness. I have mentored US Air Force service members on topics varying from Microsoft Office products, to leadership. It is my intent to help each and every student not only with the skills necessary to excel at a given subject, but also gain a drive for learning, which is critical to future success. As a father of three teenagers, it has been a privilege to be a part of their success as they approach their college years. Getting the opportunity to work with my own children has been a blessing. I look forward to passing on that type of success to other young people.
Email Kevin
I have provided both private tutoring and substitute teaching in the district for the Washington core subjects in elementary education (K-6th) which includes the ability to teach occupational education (e.g. Microsoft office word, powerpoint, excel ), science (Botany, Chemistry, Mineralogy Biology, Astronomy, Geology, Microbiology Palaeontology, Pathology, Entomology, Seismology, Forestry,Ichthyology), mathematics (multiplication, division, addition, subtraction), social studies (Ancient civilizations,... Read More
I have 12 years of formal education on the piano including two semesters of college credits. I have performed and won in numerous competitions throughout grade school and high school.
The different approaches to learning including organization, processing new information, retention, and ability to demonstration in settings to include instruction and evaluation. This set of skills is important in the academic process and critical to grasping concepts in a time sensitive world. Teaching these skills has been the backbone of my arsenal as an instructor of 24 years. The ability to react in a fire hose environment, and the discipline to stay the course during a slower... Read More
Spending many hours weekly working with children with special needs has been one of the most fulfilling jobs I have ever done. To make a difference in a child's life is humbling, and that can be especially true with a child with special needs. As a substitute paraeducator in the school district, I get this wonderful opportunity daily with grade school, middle school, and high school students.
I work as a paraeducator in our school district at the grade school, middle school, and high school levels. I have the opportunity daily to work with individuals with ADD/ADHD, and it is a wonderful experience to be a part of unlocking that potential inside of them!
Certified National Academy of Sports Medicine (NASM) physical fitness trainer. Initial certification was earned in January of 2009. Recertification required every two years. Last recertification accomplished in January of 2011. Current and qualified with Red Cross AED/CPR.
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Why didn't we do this sooner! — My daughter's second tutoring session was amazing! As she prepared for an upcoming test, Kevin was able to take apart concepts and present them to her in a way that she understood. He also impressed upon her the importance of studying and practicing her new skill - something she actually did (without me prompting) after he left. Once again, after her lesson she was beaming with confidence and commented, ...
— Vickie from Steilacoom, WA on 2/17/12
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Kevin D. passed a background check on 1/2/14. The check was ordered by Kevin through First Advantage. For more information, please review the background check information page.
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subset: commoncrawl


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Another Literal Music Video: Head Over Heels
This is another literal music video from the same guy that brought us A-Ha's Take On Me. Except now it's Tears For Fears and Head Over Heels. Jesus, music videos were freaking weird in the 80's. Thankfully we've gotten over that. Or have we? I don't know, I don't watch MTV anymore. Because I don't have cable. Or a TV. Or electricity. Or wat -- holy shit, I live in my car.
Thanks to RyanThePerson and Kokopure, both of whom have an open invitation to sleep in the trunk any time they want.
ALL NEW! Star Wars Gangsta Rap: ChroniclesAtom.com: Funny Videos | Atom Originals | Star Wars Gangsta Rap This is a Star Wars gangster rap and music video created by Bent TV. It was incredibly well made except the rappers didn't seem like real mf'ing g's. They looked like a bu... / Continue →
I know half of you love these literal music videos, and the other half wishes they'd fall in a volcano and die a quick, lava-y death (and not return from the ashes like a Phoenix). So for you literal video lovers out there, here's Beck's 'Loser', which just so happened to be o... / Continue →
This is a video created by Esteban Diácono to the music of Olafur Arnalds' Ljósið using "Adobe After Effects, particular v2, soundkeys and a little starglow". It's basically a bunch of smoke dancing around. But not like that shit in Lost! i first imported the audio and se... / Continue →


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Quantity | 25 | Blank |
Sale Price | $8.89 | $8.89 |
Free One Day Rush! This custom imprinted keepsake for fond memories with family and friends holds 36 photographs in 18 2-sided pages and includes a gift box. | |||||
Item Number: 3051 |
Standard Production: 7 Days |
Imprint Area(s): 3.00" x 3.00" (Centered Spine Left ) |
Screen Charge: $55.00 |
Multi-Color Charge: $0.99/unit + $55.00 Setup |
Product Size: 7.5"L x 5"H |
Shipping Weight: 16 lbs. per 25 |
Imprint Method: Screen Printed |
Material: Leather |
Packaging: N/A |
Notes: Set-up charge: $55.00. Price includes a one-color, one location imprint. Additional imprint color is .99 per color, per item.Please inquire about Debossing. |
Color swatches are for reference only, please see notes below.
Product Colors:
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This product has a 2 color max. Matching of output printed color to video monitor and other output devices is not accurate and should not be relied upon for color accurate matching as different output devices yield colors in varying degrees of accuracy. |
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Be the first to review the CLOSEOUT Travis & Wells Photo Album! |
FREE One Day Production! This product features a FREE One Day production option. Note, this does not include shipping/transit time. This offer applies to 1-color imprints only. |


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Spread: 24-36 inches
Height: 18-24 inches
Days to Maturity: 100 days
Sowing Method: Direct Sow/Indoor Sow
We also suggest these gardening products and ideas.
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Harvest after the shells harden, about 90 days after sowing. Cut the fruits from the vines with 1-2" of stem attached, then cure them for a week in a warm, dry location with good air circulation. Store them in a cool, dry place at 50-55¿F for use throughout the winter. Use winter squash to make pumpkin pie, or bake it and serve it as a side dish. An excellent source of vitamin A. Squash blossoms are also delicious and sweet, try dipping in batter and frying.


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Case Study | December 29, 2011
Reseller And Clients Save With Mercury's Integrated Payment Processing
Source: MercuryPOS resellers face slim profit margins due to a turbulent economy and increased competition from POS resellers who sell exclusively via the internet and appear to offer the same product for the same or less cost.
When purchasing a POS system for the first time, merchants may not understand the value a full-service reseller can provide, like a customized solution, data card security expertise, personalized service, and knowledgeable support.
To survive and thrive in the fiercely competitive sales climate, full-service POS resellers like CRS are challenged to provide an efficient solution for their merchants — one that saves time and money.


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Article ID: 2789582 - View products that this article applies to. SymptomsCollapse this table
Things to TryThese errors may occur for several reasons:
Temporary service issue or no data connection Collapse this image
webpage. This may also be caused due to a lack of connectivity, such as having poor cellular data connection, having Airplane Mode enabled, or being connected to a Wi-Fi network that is having issues. To test device connectivity, you can open Internet Explorer on the phone to see if you can browse to a web page. Once you can, try to join the Room again.Collapse this image Collapse this image
Collapse this image Collapse this image One or more of the Room members (yourself, existing or newly joining) may have reached the contact quota limit for their Microsoft account. Joining a room makes everyone Messenger friends, and if an account has reached their contact quota limit joining a Room will fail if members can't become contacts of another. All Room members, including you, should ensure their Microsoft account profile is updated and verified. To fix the problem, have all Room members follow these steps:
Collapse this image More information
To learn more about using Rooms with your phone, see the following articles: AssistanceCommunity Forum PropertiesArticle ID: 2789582 - Last Review: February 19, 2014 - Revision: 7.0


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Search results for : | save revelvent |
Save The Rave
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Trial record 4 of 360 for:
Optimizing Postpartum Contraception in Women With Preterm Births
This study is currently recruiting participants.
Verified May 2013 by University of Utah
University of Utah
Information provided by (Responsible Party):
University of Utah
ClinicalTrials.gov Identifier:
First received: May 11, 2013
Last updated: May 24, 2013
Last verified: May 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to examine the effectiveness of focused family planning counseling on the uptake and continuation of highly effective contraceptive methods (defined as the intrauterine device, implant, and both male and female sterilization methods including vasectomy, tubal ligation and Essure) during the postpartum period in women who have recently experienced a preterm delivery.
The investigators hypothesize that women with a recent preterm birth (PTB) will be more likely to initiate and continue using a highly effective method of contraception when provided with focused family planning counseling.
Condition | Intervention |
Method of Contraception Preterm Birth Recurrence |
Behavioral: Focused contraception counseling |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Health Services Research |
Resource links provided by NLM:
Further study details as provided by University of Utah:
Primary Outcome Measures:
- Use of highly effective method [ Time Frame: Three months ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Pregnancy outcomes [ Time Frame: 12 months, 18 months, 24 months, 36 months ] [ Designated as safety issue: No ]
- Use of highly effective method [ Time Frame: 12 months, 24 months, 36 months ] [ Designated as safety issue: No ]
Estimated Enrollment: | 362 |
Study Start Date: | April 2013 |
Estimated Study Completion Date: | June 2016 |
Estimated Primary Completion Date: | April 2014 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Contraception after preterm birth
Intervention name: Focused contraception counseling This intervention will be provided to those randomized to the intervention group only. This counseling will follow a pre-written, structured script describing all contraceptive methods in rank order starting with most effective to least effective in preventing unplanned pregnancy.
Behavioral: Focused contraception counseling
This intervention will be provided to those randomized to the intervention group only. This counseling will follow a pre-written, structured script describing all contraceptive methods in rank order starting with most effective to least effective in preventing unplanned pregnancy.
No Intervention: Control Group
Participants will receive the standard postpartum contraception counseling that is received by all patients who deliver at our institution.
Ages Eligible for Study: | 14 Years to 50 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Women who deliver a premature infant that is between the gestational ages of 24 weeks 0 days and 36 weeks 6 days at our institution.
Exclusion Criteria:
- Women who have delivered via cesarean section and have also had a sterilization procedure at the time of the cesarean section.
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01864629
Contact: Leah N Torres, MD | 801-581-6170 | firstname.lastname@example.com |
United States, Utah | |
University of Utah Hospital | Recruiting |
Salt Lake City, Utah, United States, 84132 | |
Contact: Leah Torres, MD 801-581-6170 firstname.lastname@example.com | |
Principal Investigator: Leah Torres, MD |
Sponsors and Collaborators
University of Utah
More Information
No publications provided
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 13, 2014
No publications provided
Responsible Party: | University of Utah |
ClinicalTrials.gov Identifier: | NCT01864629 History of Changes |
Other Study ID Numbers: | IRB_00061119 |
Study First Received: | May 11, 2013 |
Last Updated: | May 24, 2013 |
Health Authority: | United States: Institutional Review Board |
Additional relevant MeSH terms:
Recurrence Premature Birth Disease Attributes Pathologic Processes |
Obstetric Labor, Premature Obstetric Labor Complications Pregnancy Complications |
ClinicalTrials.gov processed this record on March 13, 2014


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There were 23 men's teams and 15 women's at last weekend's Anna Banana Wildcat Cross Country Invitational.
Grand Junction won the team title for the boys while Greeley West won the girls' title.
Read more...
Delta High School
Page 218 of 282
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Dynamic Adventures at Dartington, Devon are able to offer a unique variety of outdoor activities.We are a Communty Interest Company whose sole aim is to encourage access to adventure at all levels.
We are based in the stunning River Dart Valley. We provide activities for all ages and for all abilities from beginners to advanced. We welcome Schools, Companies, families, groups and individuals. We also run the Ultimate Trainee Instructor Course.(the Lychee Scheme)
Our team of qualified and experienced instructors will tailor your session to what you want, whether it's just fun or specialist skills training.
We are based at 'The Shops at Dartington' and the site offers a variety of shopping experiences including outdoor clothing, hand crafted pottery, cafés, pub and restaurants; this is a great day out for all the family.
The historic Dartington Hall provides fantastic 4 star accommodation, bar and restaurant as well as 1500 acres for you to explore with Dynamic Adventures.
The Ultimate Trainee Instructor Course (the Lychee scheme)
Spaces Avalible Now for 2014, 3-18 Months long
Change your life, have a fantastic gap year and spend it climbing, canoeing, kayaking, archery, high ropes, trekking all over the UK, European expeditions, and world wide expeditions, become an expert and start your career or just have a great time with real meaning.


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Natural Resources Lawyers and Law Firms in Hyderabad, India
Natural Resources Attorneys
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Advocates-Solicitors-Consultants. A Full Service Law Firm in India
09822720483Astrea Legal is a full service Law Firm offers a comprehensive range of legal services in the areas of Civil, Constitutional, Corporate and Criminal matters. It has an extensive network of motivated associate Lawyers. Astrea Legal has maintained unique client service approach to...
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91 40 40115222, 4020Kochhar & Co. is one of the leading and largest corporate law firms in India. The Firm enjoys the distinction of being the only Indian law firm with full service offices in the six prominent Indian cites of New Delhi, Mumbai (Bombay), Bangalore, Chennai (Madras), Gurgaon and...
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Legist Associates
Full-Service Law Firm Advising on Corporate and Commercial, IPR, ADR & Litigation and Real Estate
+91 9989006662Legist Associates is a full-service law firm based in Hyderabad, India. Our areas of practice include: Corporate and Commercial, IPR, ADR & Litigation, and Real Estate.
Law Firm's Overview
Baba & Baig Law Firm
Hyderabad, IndiaOne Stop Legal Solutions
+91 9849346748Dejure Chambers, Law Firm
Hyderabad, IndiaLitigation, Corporate and Intellectual Property Rights Law Firm in India
+91 40 64585125INTRODUCTION:; Dejure Chambers is a diverse, full service law firm and it believes effective legal representation begins with understanding our client's businesses and the environment in which they operate. Drawing on this understanding, our attorneys collaborate with clients and each other to...
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HP's Spectre XT Touchsmart laptop has a Full HD touchscreen, a slim, metal body and plenty of power, but demands £1,000 in return. Read more
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Education publisher Pearson Wednesday unveiled a new student response system for K-12 and higher ed at the FETC conference in Orlando, FL. The system, developed in partnership with technology provider Renaissance Learning, is designed to be integrated with Pearson's Prosper assessment system.
The Engage Response System combines handheld devices with software for creating interactive learning experiences for students. The RF-based handheld device contains a full numeric keypad (which can also function as a calculator), with memory to store notes and assignments. It also includes a six-line display. The receiver is a USB device. The Engage software provides a hovering toolbar that's visible on computer screens and projector images. For assessments, the system integrates with Prosper for test generation and reporting.
The Engage Response System starts at $2,199 for a single, full classroom set.
Pearson is exhibiting at the FETC conference this week in booth 802. Renaissance Learning is in booths 1055 and 1056. More information is available at the links below.
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David Nagel is the executive producer for 1105 Media's online K-12 and higher education publications and electronic newsletters. He can be reached at email@example.com. He can now be followed on Twitter at http://twitter.com/THEJournalDave (K-12) or http://twitter.com/CampusTechDave (higher education). You can also connect with him on LinkedIn at http://www.linkedin.com/profile/view?id=10390192.
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Astronomers spot galactic intruder
Friday, 19 November 2010
Astronomers have discovered a planet from another galaxy which has ended up in the Milky Way, because of galactic cannibalism.
Fertile Crescent farmers took DNA to Germany
Wednesday, 10 November 2010
DNA evidence suggests that immigrants from the Ancient Near East brought farming to Europe, and spread the practice to the region's hunter-gatherer communities, according to Australian-led research.
Neanderthal brains developed differently
Tuesday, 9 November 2010
The brains of Neanderthals and humans were similar at birth but developed differently in the first year of life, according to a German study.
Cosmic rays trace Sun's journey through space
Wednesday, 3 November 2010
Scientists may have a new tool to help them work out what sort of environment our solar system's been experiencing during its journey through our galaxy, the Milky Way.
Happiness more than gene deep
Tuesday, 5 October 2010
The idea that happiness is a genetic trait influenced by early life experiences has been challenged by new research from Germany.
Prehistoric bird sets wingspan record
Thursday, 16 September 2010
Researchers have found the remains of what they believe was an enormous bony-toothed bird with the largest wingspan ever recorded.
Researchers uncover dance moves to impress
Thursday, 9 September 2010
A European study has found that men who move their necks and trunks more to the beat are most likely to attract women.
Pulsars measure up mass of planets
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Scientists have worked out a new way to measure the mass of a planet using pulsars.
Brain 'hardware' key to flexible decisions
Tuesday, 24 August 2010
The ability to make quick decisions when they are needed depends on whether your brain connections are the neural equivalent of broadband or dial-up, an international study shows.
Butchered bones prove early meat eating
Thursday, 12 August 2010
Evidence from ancient bones found in Ethiopia suggest human ancestors were using stone tools to carve meat a million years earlier than previously thought.
Doubts over South American marsupial study
Wednesday, 28 July 2010
A new study that suggests all living marsupials originated in South America and share a common ancestor has been disputed by an Australian palaeontologist as "simplistic".
Researchers discover new octopus species
Wednesday, 21 July 2010
Scientists have for the first time collected venom from octopuses captured from the waters of Antarctica.
Proton's measure comes up short
Thursday, 8 July 2010
Scientists have discovered that a primary building block of the universe, the proton, is smaller than previously thought.
Scientists herald decade of human genome
Thursday, 24 June 2010
The decade since the human genome was first sequenced has ushered in great leaps in understanding of the origins and evolution of humans, although medical applications thus far have been limited.
Humans interbred with Neanderthals: analysis
Friday, 7 May 2010
Modern humans most likely interbred with Neanderthals, according to a landmark genome analysis that sheds light on how we evolved differently from our prehistoric cousins.


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Classics The society of mindRead it when AI was hot, but then I switched to IA. "This book tries to explain how minds work. How can intelligence emerge from non-intelligence? To answer that, we'll show that you can build a mind from many little parts, each mindless by itself." Posted on December 09, 2013 | Permalink Fritz Kahn: The little-known godfather of infographicsEvery current field has its longtime history. You should only look for connections, inspiration and influences. "Around the time when Austrian sociologist, philosopher, and curator Otto Neurath was building his ISOTYPE visual language, which laid the foundation for pictogram-based infographics, another infographic pioneer was doing something even more ambitious: The German polymath Fritz Kahn - amateur astronomer, medical scientist by training, gynecologist by early occupation, artist by inclination, writer, educator and humanist by calling - was developing innovative visual metaphors for understanding science and the human body, seeking to strip scientific ideas of their alienating complexity and engage a popular audience with those essential tenets of how life works." (Maria Popova ~ Brainpickings) Posted on November 20, 2013 | Permalink Intuitive equals familiarHow qualities of UIs become used in UX. "One of the most common terms of praise for an interface is to say that it is "intuitive" (the word should have been "intuitable" but we will bow to convention). Yet the Human Computer Interaction (HCI) literature rarely mentions the word, and for good reason. This note attempts to clarify the meaning of "intuitive" for non-HCI specialists." (Jef Raskin 1994) Posted on September 17, 2013 | Permalink Douglas Engelbart's unfinished revolutionHistory will show the meaning of some people, not today. Computing pioneer Doug Engelbart's inventions transformed computing, but he intended them to transform humans. ~ "(...) Engelbart never sought to own what he contributed to the world's ability to know. But he was frustrated to the end by the way so many people had adopted, developed, and profited from the digital media he had helped create, while failing to pursue the important tasks he had created them to do." (Howard Rheingold a.k.a. @hrheingold ~ MIT Technology Review) Posted on July 24, 2013 | Permalink The message gets the medium it deservesI have always been fascinated about how the unique characteristics of a medium define its design space. "I see this as a core principle of higher order UX; to use the medium in such a way that the medium facilitates the delivery of the message instead of polluting it. It's that pollution that brings about unanticipated consequences in what the user experiences. This is just as much a holistic experience problem as well as a nitty-gritty design and interaction problem." (Erik Flowers a.k.a. @Erik_UX) Posted on July 15, 2013 | Permalink The hut where the internet beganSame magazine as 'As We May Think'. No coincidence. "In a hut like this -- and maybe even one of these huts specifically -- Engelbart opened up that issue of LIFE and read Bush's Atlantic article. The ideas in the story plowed new intellectual terrain for Engelbart, and the seeds that he planted and nurtured there over the next twenty years grew, with the help of millions of others, into the Internet you see today." Posted on July 08, 2013 | Permalink The WorldWideWeb is a wide-area hypermedia information retrieval initiativeA proposal which changed the world forever. "The WWW project merges the techniques of information retrieval and hypertext to make an easy but powerful global information system. The project is based on the philosophy that much academic information should be freely available to anyone. It aims to allow information sharing within internationally dispersed teams, and the dissemination of information by support groups. Originally aimed at the High Energy Physics community, it has spread to other areas and attracted much interest in user support, resource discovery and collaborative work areas." (CERN) Posted on April 30, 2013 | Permalink A talk with computer graphics pioneer Ivan SutherlandAnother giant with strong shoulders. "I couldn't end a conversation with one of the fathers of computer graphics without asking him where he thought the field might go in the next fifty years. I should have remembered, though: Sutherland had already explained to me that he's not into the prediction game." (Harry McCracken a.k.a. @harrymccracken ~ TIME.com) Posted on April 16, 2013 | Permalink 40 years of icons: The evolution of the modern computer interfaceKnowing where you come from is a great foundation. "The greatest thing is that this has sort of become a sandbox for the mind. It's a medium, not just a calculating machine. We now have this thing in front of us, it allows us to paint, to write, to listen to music. It mesmerizes us and steals our lives. I think it is the invention of the last 500 years. And we're waiting to see what it does next." (Jesse Hicks a.k.a. @jessehixxx ~ The Verge) Posted on April 12, 2013 | Permalink "The music is not in the piano"One of the giants on whom's shoulders we stand. Interview with computing pioneer Alan Kay ~ "One way to think of all of these organizations is to realize that if they require a charismatic leader who will shoot people in the knees when needed, then the corporate organization and process is a failure. It means no group can come up with a good decision and make it stick just because it is a good idea. All the companies I've worked for have this deep problem of devolving to something like the hunting and gathering cultures of 100,000 years ago. If businesses could find a way to invent "agriculture" we could put the world back together and all would prosper." (David Greelish ~ Techland) Posted on April 03, 2013 | Permalink The lady and the antelope: Suzanne Briet's contribution to the French Documentation MovementRemarkable woman in the Paul Otlet trajectory. "During her thirty years at the Bibliothèque Nationale (BN), Suzanne Briet (1894-1989) made important theoretical, organizational, and institutional contributions to the documentation movement in France. This paper attempts to place her documentation work within the context of the far-reaching reform of French libraries, with special attention to the transformation of the BN. Like her colleagues in special libraries, Briet embraced modernity and science. However, because of her strong orientation toward humanistic scholarship, she viewed documentation service and bibliographic orientation as an enhancement rather than a rejection of the scholarly traditions of the national library. This paper will focus on her efforts to integrate the innovative ideas of the documentation movement into the practice of librarianship at the Bibliothèque Nationale." Posted on April 02, 2013 | Permalink The origins of the internet in Europe (1895-2013): Collecting, indexing & sharing knowledgeHave I been waiting for this one. "Brussels, Belgium, Europe, 1895: two men shared a dream of 'indexing and classifying the world's information'. Paul Otlet and Henri La Fontaine's work foreshadowed the network of knowledge that a century later became the Internet with its search engines! Otlet and La Fontaine aimed to preserve peace by assembling knowledge and making it accessible to the entire world. They built an international documentation center called Mundaneum. They invented the modern library Universal Decimal Classification system. La Fontaine won the Nobel Peace Prize in 1913. By 1935, their Mundaneum grew to a staggering 16 million cards covering subjects ranging from the history of hunting dogs to finance! World War II and the death of both founders slowed down the project. Although many Mundaneum archives were stored away, some even in the Brussels subway, volunteers kept the dream alive. The French community government of Belgium brought most of the archives to a beautiful Art Deco building in the heart of Mons near Brussels." Posted on February 21, 2013 | Permalink Man-Computer SymbiosisOne of the giants on whose shoulders we (HCI) stand. "Man-computer symbiosis is an expected development in cooperative interaction between men and electronic computers. It will involve very close coupling between the human and the electronic members of the partnership. The main aims are (1) to let computers facilitate formulative thinking as they now facilitate the solution of formulated problems, and (2) to enable men and computers to cooperate in making decisions and controlling complex situations without inflexible dependence on predetermined programs. In the anticipated symbiotic partnership, men will set the goals, formulate the hypotheses, determine the criteria, and perform the evaluations. Computing machines will do the routinizable work that must be done to prepare the way for insights and decisions in technical and scientific thinking. Preliminary analyses indicate that the symbiotic partnership will perform intellectual operations much more effectively than man alone can perform them. Prerequisites for the achievement of the effective, cooperative association include developments in computer time sharing, in memory components, in memory organization, in programming languages, and in input and output equipment." (J.C.R. Licklider a.k.a. Lick, 1960) Posted on January 09, 2013 | Permalink Bill Moggridge 1943-2012Paying tribute to one of our founding fathers. "A tribute to esteemed museum director Bill Moggridge, who passed away on September 8, 2012 following a battle with cancer. Hear about his pioneering work and influence in the field of design from Tim Brown and David Kelley of IDEO, Bernie Roth of Stanford University and Caroline Baumann and Cara McCarty of Cooper-Hewitt, National Design Museum." (Cooper-Hewitt, National Design Museum) Posted on September 10, 2012 | Permalink Designing Services That DeliverThe founding article (1984) of Service Design and service blueprints. "Faced with service problems, we tend to become somewhat paranoid. Customers are convinced that someone is treating them badly; managers think that recalcitrant individual employees are the source of the malfunction. Thinly veiled threats by customers and managers are often first attempts to remedy the problem; if they fail, confrontation may result." (G. Lynn Shostack) Posted on June 22, 2012 | Permalink 25 years of HyperCard: The missing link to the WebMemory lane. "HyperCard's problem was that Apple never quite figured out what the software was for." (Matthew Lasar a.k.a. @MatthewLasar ~ Ars Technica) Posted on May 31, 2012 | Permalink Engelbart's ViolinAnd boy, what a symphonies did it bring us. "In the mind of today's technological entrepreneur, the ideal user (and employee) is semi-skilled - or unskilled entirely. The ideal user interface for such a person never rewards learning or experience when doing so would come at the cost of immediate accessibility to the neophyte. This design philosophy is a mistake - a catastrophic, civilization-level mistake. There is a place in the world for the violin as well as the kazoo. Modern computer engineering is kazoo-only, and keyboards are only the most banal example of this fact. Far more serious - though less obvious - problems of this kind tie our hands and wastefully burn our 'brain cycles'. Professional equipment, whose mastery requires dedication and mental flexibility, may not be appropriate for casual users. But surely it is appropriate - in fact, necessary - for professionals? Just why is this idea confined to crackpots shouting in the wilderness? I hope to learn a definitive answer to this conundrum some day." (Stanislav Datskovskiy ~ Loper OS) Posted on May 31, 2012 | Permalink Shift HappensAlways been a great admirer of Thomas Kuhn. "The problems that dominated Kuhn's life after his great moment of insight arose not because Kuhn wasn't brilliant enough. Rather, they arose and persist because while we increasingly understand that the old metaphysical paradigm has failed, for several generations now we have not found our new paradigm. Our culture has inappropriately latched on to Kuhn's message as an exaltation of the rootless disconnection of our ideas from the world because we were ready to hear that knowledge is not apart from our knowing of it. But he and we have not yet come to a new shared understanding about what it means to live truthfully as humans." (David Weinberger a.k.a. @dweinberger) Posted on April 24, 2012 | Permalink Honoring and supporting Belgian Internet pioneersJustice will be done to those with universal ideas and visions. "Decades before the creation of the World Wide Web, Paul Otlet and Henri La Fontaine envisaged a paper archival system of the world's information. They built a giant international documentation centre called Mundaneum, with the goal of preserving peace by assembling knowledge and making it accessible to the entire world. For us at Google, this mission sounds familiar." (Google | Official blog) Posted on March 14, 2012 | Permalink Information Overload Is Not Unique To Digital AgeI'm always thrilled when new historical connections are found. "It is a constant complaint: We're choking on information. The flood of data on the Web has reached mind boggling proportions, and it shows no signs of stopping. But wait, says Harvard professor Ann Blair - this is not a new condition. It's been part of the human experience for centuries." Posted on February 05, 2012 | Permalink Lost Stories Information Design HistoryInformation design, one of the many giant fields on which shoulders we stand. "In a competitive business marketplace, not everyone wants to acknowledge that each generation tends to learn from, build on or divert from the previous generations ideas and output. We see this phenomenon clearly evident in the various streams of Information Design history." Posted on February 03, 2012 | Permalink How the Knowledge Navigator video came aboutGreat read about the making of the iconic vision video by AAPL. "Sparked by the introduction of Siri, as well as products such as iPad and Skype, there have been many recent posts and articles tracing the technologies back to a 1987 Apple video called Knowledge Navigator. The video simulated an intelligent personal agent, video chat, linked databases and shared simulations, a digital network of university libraries, networked collaboration, and integrated multimedia and hypertext, in most case decades before they were commercially available. Having been involved in making Knowledge Navigator with some enormously talented Apple colleagues, I thought I would correct the record once and for all about what really happened." (Bud Colligan a.k.a. @collbud ~ Dubberly Design Office) Posted on January 31, 2012 | Permalink Why Hypercard Had to DieShould be part of "The Web That Wasn't". "I was a Hypercard child - though our friendship was brief." (Loper OS) Posted on December 05, 2011 | Permalink Networked Knowledge, Decades Before GoogleGreat reference article to pass around. The more Otlet, the better. "He dreamed of a 'mechanical, collective brain' and his complex system for indexing information could be considered an analog version of Google. Belgian lawyer and librarian Paul Otlet died in 1944, poor and disillusioned. But his work is now being looked at in a whole new light." (Meike Laaff ~ Der Spiegel) Posted on November 23, 2011 | Permalink Origins of the Apple Human InterfaceA first hand recollection of ideas, concepts, and prototypes. This is a verbatim transcript of a public lecture given on October 28, 1997. ~ "We got clearance, thankfully, from the Apple lawyers, which came about two - three weeks ago, so we could give it here, just in time to announce it. We're grateful to Apple to release this for public disclosure, because we think it's of general interest." (Larry Tesler a.k.a. @nomodes and Chris Espinosa a.k.a. @cdespinosa) Posted on November 23, 2011 | Permalink Classic: Electric Word, July 1990 (.pdf)The Least Boring Computer Magazine In The World ~ "It's always a crap shoot, you never know how an issue is going to turn out.Just coordinating all the elements is a task only slightly less humbling than trying to align all the planets. No wonder it's become a standing joke around the EW office: that moment each issue when we start laying out pages and I get to see the magazine in its final form for the first time, when I proclaim in genuine surprise, hey, this issue isn't so bad - in fact, it's even better than the last. What makes it doubly gratifying this time is that this is the first issue of the rest of our lives. Thirty six months and two publishers later, ElectricWord is independent." (Louis Rosetto) ~ courtesy of johnrynne Posted on July 04, 2011 | Permalink The Untold Story of How My Dad Helped Invent the First Mac"Jef Raskin, my father, helped develop the Macintosh, and I was recently looking at some of his old documents and came across his February 16, 1981 memo detailing the genesis of the Macintosh. It was written in reaction to Steve Jobs taking over managing hardware development. Reading through it, I was struck by a number of the core principals Apple now holds that were set in play three years before the Macintosh was released. Much of this is particularly important in understanding Apple's culture and why we have the walled-garden experience of the iPhone, iPad, and the App Store." (Aza Raskin) Posted on February 17, 2011 | Permalink The Playboy Interview: Marshall McLuhan"(...) all media - in and of themselves and regardless of the messages they communicate - exert a compelling influence on man and society. Prehistoric, or tribal, man existed in a harmonious balance of the senses, perceiving the world equally through hearing, smell, touch, sight and taste." (Next Nature) Posted on January 27, 2011 | Permalink The MIT/Brown Vannevar Bush Symposium (1995)"The MIT/Brown Vannevar Bush Symposium was held October 12-13, 1995, at MIT, marking the 50th anniversary of Vannevar Bush's seminal article "As We May Think" (Atlantic Monthly, July 1945). The video archives from the lectures and panel discussions from that Symposium are now available online as part of the Doug Engelbart Archives collection at the Internet Archive as follows. Refer to Symposium program for title and abstract for each talk, as well as speaker bios, and panel notes; speakers' slides were captured but can no longer be viewed." (Douglas Engelbart Institute) Posted on November 19, 2010 | Permalink WorldWideWeb: Proposal for a HyperText Project"HyperText is a way to link and access information of various kinds as a web of nodes in which the user can browse at will. Potentially, HyperText provides a single user-interface to many large classes of stored information such as reports, notes, data-bases, computer documentation and on-line systems help. We propose the implementation of a simple scheme to incorporate several different servers of machine-stored information already available at CERN, including an analysis of the requirements for information access needs by experiments." (Tim Berners-Lee ~ November 12, 1990) Posted on November 12, 2010 | Permalink Inside The Mundaneum"On the night of June 1, 1934, a Belgian information scientist named Paul Otlet sat in silent, peaceful protest outside the locked doors of a government building in Brussels from which he had just been evicted. Inside was his life's work: a vast archive of more than twelve million bibliographic three-by-five-inch index cards, which attempted to catalog and cross-reference the relationships among all the world's published information. For Otlet, the archive was at the center of a plan to universalize human knowledge. He called it the Mundaneum, and he believed it would usher in a new era of peace and progress. The Belgian government, however, had come to view Otlet and his fine mess of papers, dusty boxes, and customized filing cabinets as a financial and political nuisance." (Molly Springfield ~ Triple Canopy) Posted on June 29, 2010 | Permalink Invisible Revolution"(...) the story of Doug Engelbart, the man who invented much of the information environment we live in today - the computer mouse, word processing, email, hypertext and so on. In short: Interactive computing. This is his story, and the story of his fellow dreamers, thinkers, doers - revolutionaries - who changed our lives forever." (Frode Hegland & Fleur Klijnsma) Posted on March 19, 2010 | Permalink Otlet's Models of the World: A Historical Knowledge Space Lab"I would like to draw attention to the scientific models of the Belgian information pioneer Paul Otlet who albeit that they are standing in positivist and Modernist tradition can still be relevant for mechanical and manual modelling of science within the Semantic Web and Web 2.0." (Charles van den Heuvel - Modelling Science) Posted on December 16, 2009 | Permalink Web 2.0 and the Semantic Web in Research from a Historical PerspectivePre-publication - The designs of Paul Otlet (1868-1944) for telecommunication and machine readable documentation to organize research and society - "At the end of the nineteenth and in the first decades of the twentieth century various European scholars, like Patrick Geddes, Paul Otlet, Otto Neurath, Wilhelm Ostwald explored the organisation, enrichment and dissemination of knowledge on a global level to come to a peaceful, universal society. We focus on Paul Otlet (1868-1944) who developed a knowledge infrastructure to update information mechanically and manually in collaboratories of scholars. First the Understanding Infrastructure (2007) report, that Paul N. Edwards et al. wrote on behalf of NSF, will be used to position Otlet's knowledge organization in their sketched development from information systems to information internetworks or webs. Secondly, the relevance of Otlet's knowledge infrastructure will be assessed for Web 2.0 and Semantic Web applications for research. The hypothesis will be put forward that the instruments and protocols envisioned by Otlet to enhance collaborative knowledge production, can still be relevant for current conceptualizations of 'scientific authority' in data sharing and annotation in Web 2.0 applications and the modeling of the Semantic Web." (Charles van den Heuvel in: Knowledge Organization, 36 (4) 214-226) Posted on December 13, 2009 | Permalink Building Society, Constructing Knowledge, Weaving the WebPre-publication - Otlet's Visualizations of a Global Information Society and His Concept of a Universal Civilization - "I have discussed at such length Berners-Lee's Weaving the Web in order to compare the US-oriented views of the history and future of the World Wide Web, as its proclaimed inventor expressed them toward the end of the twentieth century, with the ideas explored 50 years or more earlier by Paul Otlet and his colleagues about knowledge organization on a global level. My aim is to try to show how some of the issues that were important in explaining the origin of the World Wide Web and in predicting its future were already being explored at the beginning of the twentieth century by a number of European pioneers, who proposed similar solutions and encountered similar problems to Berners-Lee." (Charles van den Heuvel in W. Boy Rayward [ed.] European Modernism and the Information Society, pp 127-153) Posted on December 13, 2009 | Permalink Dec. 10, 1944: Web Visionary Passes Into Obscurity"Some historians see in Otlet's work a prototype of the World Wide Web and the hyperlink. Although unsuccessful, it was one of the first known attempts to provide a framework for connecting all recorded culture by creating flexible links that could rapidly lead researchers from one document to another — and perhaps make audible the previously unheard echoes between them. Anticipating postmodern literary theory, Otlet posited that documents have meaning not as individual texts, but only in relationship to each other." (Wired) - courtesy of lievenbaeten Posted on December 10, 2009 | Permalink Facts and Frameworks in Paul Otlet's and Julius Otto Kaiser's Theories of Knowledge Organization"In this article, I sketch Otlet's and Kaiser's ideas about information analysis and compare the types of knowledge organization systems (KOSs) that they constructed on the basis of these ideas. As we shall see, Otlet and Kaiser held very similar views about the possibility – and desirability – of disaggregating documents into information units and organizing the latter into indexed information files. Both men also agreed on the technological means to implement their information-analytic approach." (Thomas M. Dousa - ASIS&T Bulletin Dec/Jan 2010) Posted on December 04, 2009 | Permalink How Xanadu Works: Technical Overview"Pause for a moment and think about the history here. 1993 is 16 years ago as I write this, about the same span of time between Vannevar Bush's groundbreaking 1945 article 'As We May Think' and Nelson's initial work in 1960 on what would become the Xanadu project. As far as software projects go, this one has some serious history." (Micah Dubinko - Micahpedia) - courtesy of markbernstein Posted on November 26, 2009 | Permalink European Modernism and the Information Society: Informing the Present, Understanding the Past"Uniting a team of international and interdisciplinary scholars, this volume considers the views of early twentieth-century European thinkers on the creation, dissemination and management of publicly available information. Interdisciplinary in perspective, the volume reflects the nature of the thinkers discussed, including Otto Neurath, Patrick Geddes, the English Fabians, Paul Otlet, Wilhelm Ostwald and H. G. Wells. The work also charts the interest since the latter part of the nineteenth century in finding new ways to think about and to manage the growing body of available information in order to achieve aims such as the advancement of Western civilization, the alleviation of inequalities across classes and countries, and the promotion of peaceful coexistence between nations. In doing so, the contributors provide a novel historical context for assessing widely-held assumptions about today's globalized, 'post modern' information society. This volume will interest all who are curious about the creation of a modern networked information society." (W. Boyd Rayward) - Introduction chapter available for download Posted on July 02, 2009 | Permalink CHIstory"If I have seen farther, it is because I stood on the shoulders of giants...and then I looked down at those giants and saw the silly videos they made back in the day. CHI Video Showcase 2009." Posted on April 14, 2009 | Permalink Macintosh: 25 Years"Although its individual features weren't new, the Mac offered integration, the expectation of a GUI, and interface consistency." (Jakob Nielsen - Alertbox) Posted on February 02, 2009 | Permalink In Venting, a Computer Visionary Educates"The look back by this forward-thinking man is not without its bitterness. The Web, after all, can be seen as a bastardization of his original notion that hyperlinks should point both forward and backward." (John Markoff - NYT) - Chapter summaries available. Posted on January 11, 2009 | Permalink Engelbart and the Dawn of Interactive ComputingEvent videos available - "On December 9, 2008 at Stanford University's Memorial Auditorium, SRI International commemorated the 40th anniversary of the world debut of personal and interactive computing by Dr. Douglas C. Engelbart and the SRI Augmentation Research Center (...) Speakers at the 2008 event included original participants in the 1968 demo and presentations on Doug Engelbart's vision to use computing to augment society's collective intellect and ability to solve the complex issues of our time." (A 40th Anniversary Celebration) Posted on January 01, 2009 | Permalink Architectures of Global Knowledge"The Mundaneum, a series of museums, was meant to promote international understanding. The concept was conceived by Paul Otlet (1868-1944), an information theorist and librarian, who commissioned Le Corbusier to design a 'cité mondiale', an institution for all the world's knowledge. Charles van den Heuvel discusses how Otlet's thinking about distributive networks resonates in Tim Berners-Lee's World Wide Wide." (Charles van den Heuvel) Posted on October 15, 2008 | Permalink Starfire"The film, developed in 1992, predicted the explosive growth of the world wide web at a time before graphical web browsers even existed. Starfire: The Directors' Cut explores in candid detail a technological future based on industry cooperation, human-centered design, and the continued presence of bad guys." (AskTog - Starfire: A Vision of Future Computing) Posted on June 19, 2008 | Permalink One Dead Media"It is hard to find an old technology that is not available in any form any where on earth. But today I may have found one. Alex Wright's story in the New York Times about Paul Otlet, the little-known Belgian who worked out an early version of hypertext (...) prompted a reader to point out a system similar to Otlet's that was once available commercially in the US." (Kevin Kelly - The Technium) Posted on June 18, 2008 | Permalink The Web Time Forgot"On a fog-drizzled Monday afternoon, this fading medieval city feels like a forgotten place. Apart from the obligatory Gothic cathedral, there is not much to see here except for a tiny storefront museum called the Mundaneum, tucked down a narrow street in the northeast corner of town. It feels like a fittingly secluded home for the legacy of one of technology's lost pioneers: Paul Otlet." (Alex Wright - The New York Times) Posted on June 17, 2008 | Permalink International organisation and dissemination of knowledge : Selected essays of Paul OtletTranslated and edited with an introduction by W. Boyd Rayword (1990) - "We must bring together a collection of machines which simultaneously or sequentially can perform the following operations: (1) The transformation of sound into writing; (2) The reproduction of this writing in as many copies as are useful; (3) The creation of documents in such a way that each item of information has its own identity and, in its relationships with those items comprising any collection, can be retrieved as necessary; (4) A Classification number assigned to each item of information; the perforation of documents correlated with these numbers; (5) Automatic classification and filing of documents; (6) Automatic retrieval of documents for consultation and presented either direct to the enquirer or via machine enabling written additions to be made to them; (7) Mechanical manipulation at will of all the listed items of information in order to obtain new combinations of facts, new relationships of ideas, and new operations carried out with the help of numbers. The technology fulfilling these seven requirements would indeed be a mechanical, collective brain." (internet archive) Posted on June 11, 2008 | Permalink Traité de documentationFor those of you proficient in French - "His 1934 masterpiece, the Traité de documentation, was reprinted in 1989 by the Centre de Lecture publique de la Communauté française in Belgium. The original edition has recently been digitized (...)" (Paul Otlet 1934) Posted on November 12, 2007 | Permalink The Real Computer Revolution Hasn't Happened Yet"32 years ago in 1975 I was one of several lucky Americans who were invited to Pisa to help celebrate 20 years of computer science in Italy. I presented a paper on the first fruits of our attempts to invent personal computing at Xerox PARC. Over the years I somehow lost that paper, but Porfessor Attardi, who was more organized than I, was able to locate his copy and it has been republished as part of our cderemonies today. It is tempting in this talk to go through that paper and see how this past work influenced today." (Alan Kay - VRI) Posted on November 06, 2007 | Permalink Stewart Brand Meets The Cybernetic CountercultureBook excerpt - "Like a cross between a touring rock entourage and a commune, USCO was more than a performance team. It was a social system unto itself. Through it, Brand encountered the works of Norbert Wiener, Marshall McLuhan, and Buckminster Fuller - all of whom would become key influences on the Whole Earth community - and began to imagine a new synthesis of cybernetic theory and countercultural politics." (Fred Turner - EDGE) Posted on October 05, 2006 | Permalink Ted Nelson's Computer Paradigm, Expressed as One-Liners"The purpose of computers is human freedom." (Theodor Holm Nelson) Posted on June 22, 2006 | Permalink Emanuel Goldberg, Electronic Document Retrieval, And Vannevar Bush's Memex"Vannevar Bush's famous paper 'As We May Think' (1945) described an imaginary information retrieval machine, the Memex. The Memex is usually viewed, unhistorically, in relation to subsequent developments using digital computers. This paper attempts to reconstruct the little-known background of information retrieval in and before 1939 when 'As We May Think' was originally written. The Memex was based on Bush's work during 1938-1940 developing an improved photoelectric microfilm selector, an electronic retrieval technology pioneered by Emanuel Goldberg of Zeiss Ikon, Dresden, in the 1920s. Visionary statements by Paul Otlet (1934) and Walter Schuermeyer (1935) and the development of electronic document retrieval technology before Bush are examined." (Michael K. Buckland) Posted on April 10, 2006 | Permalink The Universe of Information: The Work of Paul Otlet for Documentation and International Organizationby W. Boyd Rayward - University of Chicago, Published for International Federation for Documentation (IFID) by All-Union Institute for Scientific and technical Information (VINITY) Moscow 1975 - (courtesy of Michael Buckland) Posted on April 09, 2006 | Permalink It's the journey and the destination: Shape and the emergent property of genre in evaluating digital documents"(...) this paper will extend the analysis of 'user navigation' to the evaluation of user behaviour in web environments. In so doing, the present authors will attempt to unify work in the area of structural representation of content with models of navigation based on physical movement." (Andrew Dillon and Misha W. Vaughan 1997) - courtesy of petermorville Posted on March 04, 2006 | Permalink What is Documentation?"Suzanne Briet ('Madame Documentation') was an important French Documentalist just before and following the Second World War. Though others preceded her, Briet was unique in so strongly attributing to documentation and to documentary signs a cultural origin and function. In this she followed the founder of European Documentation, Paul Otlet, but she differed from Otlet in that she understood 'science', 'culture', and thus documentation more in the context of military-industrial post-war capitalist economies and in terms of the global 'development' of the time than in terms of the harmonious world of global 'knowledge' that Otlet had envisioned. In this way, Briet stands between Otlet's information utopia (reminiscent of the world industrial exhibitions of the 19th and early 20th centuries) and information theory and cybernetics in the United States which saw human culture and language as troublesome mediums for successful communication and information transmission." (Translated by Ron Day and Laurent Martinet) Posted on March 01, 2006 | Permalink The Business of Understanding"(...) Richard Wurman explains how information architects can open themselves up to understanding, learning, and ultimately being able to explain information to others." (Richard Saul Wurman - informit.com) Posted on February 23, 2006 | Permalink The Attention Economy and the Net"If the Web and the Net can be viewed as spaces in which we will increasingly live our lives, the economic laws we will live under have to be natural to this new space. These laws turn out to be quite different from what the old economics teaches, or what rubrics such as "the information age" suggest. What counts most is what is most scarce now, namely attention. The attention economy brings with it its own kind of wealth, its own class divisions - stars vs. fans - and its own forms of property, all of which make it incompatible with the industrial-money-market based economy it bids fair to replace. Success will come to those who best accommodate to this new reality." (Michael H. Goldhaber - First Monday 2.4) Posted on January 16, 2006 | Permalink Informing Ourselves To Death"(...) there can be no disputing that the computer has increased the power of large-scale organizations like military establishments or airline companies or banks or tax collecting agencies. And it is equally clear that the computer is now indispensable to high-level researchers in physics and other natural sciences. But to what extent has computer technology been an advantage to the masses of people? To steel workers, vegetable store owners, teachers, automobile mechanics, musicians, bakers, brick layers, dentists and most of the rest into whose lives the computer now intrudes? These people have had their private matters made more accessible to powerful institutions." (Neil Postman) - courtesy of designobserver Posted on December 15, 2005 | Permalink Computing machinery and intelligence"Propose to consider the question, 'Can machines think?' This should begin with definitions of the meaning of the terms 'machine 'and 'think'. The definitions might be framed so as to reflect so far as possible the normal use of the words, but this attitude is dangerous. If the meaning of the words 'machine' and 'think 'are to be found by examining how they are commonly used it is difficult to escape the conclusion that the meaning and the answer to the question, 'Can machines think?' is to be sought in a statistical survey such as a Gallup poll. But this is absurd. Instead of attempting such a definition I shall replace the question by another, which is closely related to it and is expressed in relatively unambiguous words." (Alan Turing, 1950) Posted on November 29, 2005 | Permalink Tools for Thought"(...) an exercise in retrospective futurism; that is, I wrote it in the early 1980s, attempting to look at what the mid 1990s would be like. My odyssey started when I discovered Xerox PARC and Doug Engelbart and realized that all the journalists who had descended upon Silicon Valley were missing the real story." (Howard Rheingold) - courtesy of victor lombardi Posted on November 21, 2005 | Permalink Visualizing the Organization and Dissemination of Knowledge"A pen and ink sketch of 1943, the year before Otlet died, brings together his ideas on a global networked world." (Envisioning a Path to the Future) Posted on August 01, 2005 | Permalink The Structure of Scientific Revolutions"Throughout thirteen succinct but thought-provoking chapters, Kuhn argues that science is not a steady, cumulative acquisition of knowledge. Instead, science is 'a series of peaceful interludes punctuated by intellectually violent revolutions' [Nicholas Wade, writing for Science], which he described as 'the tradition-shattering complements to the tradition-bound activity of normal science.' After such revolutions, 'one conceptual world view is replaced by another.'" (Thomas Kuhn) - courtesy of anne galloway Posted on May 16, 2005 | Permalink The Historical Development of Information Infrastructures and the Dissemination of Knowledge: A Personal Reflection"With the advent of the Internet and the Web, it has become clear how pioneering and important historically the work of Paul Otlet and his colleagues was. It seems yet even more relevant today with the recently announced agreement between Google and a number of research libraries to digitize and make their collections available through the Web." (W. Boyd Rayward - ASIS&T Bulletin April/May 2005) Posted on April 28, 2005 | Permalink Colon classification: An outline with examples"Notation and examples are taken selectively from: Colon classification. Basic classification: 6th edition / S R Ranganathan -- Sarada Ranganathan endowment for library science: Bangalore: 1960. SRELS has been asked permission of reproducing." (S.R. Ranganathan) - courtesy of petervandijck Posted on March 26, 2005 | Permalink Architecture of Knowledge: The Mundaneum and European Antecedents of the World Wide Web"Various European scholars and scientists considered at the end of the 19th and the first decades of the 20th Century new ways to unite science and art of the world. They sought for new ways to store and retrieve knowledge on a global level. They wanted to find ways of representing our knowledge of the world, of simplifying and visualizing it, of ordering it in new ways for universal access to it. They developed new comprehensive classification systems, new standards to store and organize data. They explored what were the new technologies of their time to try to overcome the inefficiencies of the book and to find substitutes for it. (...) Buildings and user are considered both transmitters and receivers of information that shapes continuously the architectural form. Architecture and knowledge are interrelated." (The Project - Maastricht McLuhan Institute) Posted on August 23, 2004 | Permalink A Framework for Representing Knowledge"Here is the essence of the theory: When one encounters a new situation (or makes a substantial change in one's view of the present problem) one selects from memory a structure called a Frame. This is a remembered framework to be adapted to fit reality by changing details as necessary. A frame is a data-structure for representing a stereotyped situation, like being in a certain kind of living room, or going to a child's birthday party. Attached to each frame are several kinds of information. Some of this information is about how to use the frame. Some is about what one can expect to happen next. Some is about what to do if these expectations are not confirmed." (Marvin Minksy - MIT CSAI Lab) Posted on July 19, 2004 | Permalink 10 Classics from Cognitive Science"The editorial board of Cognitive Science has identified several classic articles that appeared in our journal over the last couple of decades." (Cognitive Science Society) - courtesy of peter van dijck Posted on April 24, 2004 | Permalink Aristotle's CategoriesOriginal text translated by E. M. Edghill (The Classical Library) Posted on March 18, 2004 | Permalink Xanalogical Structure, Needed Now More than Ever: Parallel Documents, Deep Links to Content, Deep Versioning, and Deep Re-Use"Xanalogical literary structure is a unique symmetrical connective system for text (and other separable media elements), with two complementary forms of connection that achieve these functions -- survivable deep linkage (content links) and recognizable, visible re-use (transclusion). Both of these are easily implemented by a document model using content lists which reference stabilized media." (Theodor Holm Nelson - ACM Computing Surveys Hypertext and Hypermedia Symposium) Posted on March 08, 2004 | Permalink Computer Lib/Dream Machines Retrospective"This astonishingly prescient book originally written and published by by Theodor H. Nelson in 1974 in a glorious oversized format is one of the 'tap roots' of the soon to be born microcomputer and "cyber" cultures. The following pages provide a retrospecitve of this work and Ted's current projects and vision. We will present excerpts from the 1975 (second?) edition, kindly provided to us by Dan Croghan." (DigiBarn Computer Museum) - courtesy of anne galloway Posted on February 17, 2004 | Permalink A New Kind of Science (online version)Immediate access to the complete book (text and images, fully searchable, 30,000+ links, and many enhanced features) - "This book is the culmination of nearly twenty years of work that I have done to develop that new kind of science. I had never expected it would take anything like as long, but I have discovered vastly more than I ever thought possible, and in fact what I have done now touches almost every existing area of science, and quite a bit besides." (Stephen Wolfram - wolframscience) - Limited registration required Posted on February 06, 2004 | Permalink The 20th Anniversary of the Apple Macintosh Computer!"On January 24, 1984 the personal computing movement was changed forever with the Superbowl launch of Apple's Macintosh computer. While the graphical user interface, mouse, and bitmapped display+printing had been around for more than a decade, the Mac represented the first combining of these key innovations into a beautifully crafted package that an ordinary consumer could pick up and use in daily life. The Mac went on to spawn several revolutions including the 'Desktop Publishing' phenomenon of the 80s. This site is a special project of the DigiBarn Computer Museum to bring together some of the rarest artifacts relating to the Mac (many never seen online or published in any way). We will also pull together many materials that will give you an idea of where the Mac came from, predecessor systems, people and organizations, and where the Mac fits today in our evolutionary tree of visual computing." (DigiBarn Computer Museum) Posted on January 20, 2004 | Permalink History of the Tube Map"The striking symbol that is recognised across the globe was the brainchild of Underground electrical draughtsman, Harry Beck, who produced this imaginative yet stunningly simple design back in 1933." (London Underground) Posted on January 06, 2004 | Permalink A short history of structured flowcharts"The fascinating history and evolution of structured flowcharts (usually called Nassi-Shneiderman Diagrams or structograms) goes back to 1972. As a graduate student, I got the idea while attending an ACM organized talk in New York by Michael Jackson on structured programming. If GOTOs were to be avoided, then shouldn't the lines in old flowcharts be avoided as well. Fifteen minutes of sketching led to the first ideas of sequence, conditionals and iteration." (Ben Shneiderman) Posted on November 12, 2003 | Permalink Vitruvius PollioThe Ten Books on Architecture - ed. Morris Hicky Morgan (The Perseus Digital Library- Tufts University) Posted on June 09, 2003 | Permalink Hypertext Publishing and the Evolution of Knowledge"Media affect the evolution of knowledge in society. A suitable hypertext publishing medium can speed the evolution of knowledge by aiding the expression, transmission, and evaluation of ideas. If one aims, not to compete with the popular press, but to supplement journals and conferences, then the problems of hypertext publishing seem soluble in the near term. The direct benefits of using a hypertext publishing medium should bring emergent benefits, helping to form intellectual communities, to build consensus, and to extend the range and efficiency of intellectual effort. These benefits seem numerous, deep, and substantial, but are hard to quantify. Nonetheless, rough estimates of benefits suggest that development of an adequate hypertext publishing medium should be regarded as a goal of first-rank importance." (K. Eric Drexler - Foresight Institute) Posted on May 07, 2003 | Permalink Software Design Manifesto"What is design? What makes something a design problem? It's where you stand with a foot in two worlds - the world of technology and the world of people and human purposes and you try to bring the two together." (Mitch Kapor 1990) Posted on April 04, 2003 | Permalink The 1968 Demo of Demos"(...) the public debut of the computer mouse. But the mouse was only one of many innovations demonstrated (...) including hypertext, object addressing and dynamic file linking, as well as shared-screen collaboration involving two persons at different sites communicating over a network with audio and video interface." (Douglas Carl Engelbart - MouseSite) Posted on December 05, 2002 | Permalink Information Design: The Design and Evaluation of Signs and Printed MaterialTable of Contents (Harm Zwaga and Ronald Easterby eds. 1984) Posted on November 13, 2002 | Permalink As We May ThinkThis article was originally published in the July 1945 issue of The Atlantic Monthly. (Vannevar Bush - The Atlantic Monthly) Posted on August 15, 2002 | Permalink The Magical Number Seven, Plus or Minus TwoSome Limits on Our Capacity for Processing Information (George A. Miller 1956) Posted on January 15, 2002 | Permalink Information Interaction DesignA Unified Field Theory of Design s(Nathan Shedroff 1994) Posted on December 05, 2001 | Permalink The Powers of TenJourney to the edge of the universe and back down to the quark (Charles and Ray Eames) Posted on October 12, 2001 | Permalink Augmenting Human Intellect: A Conceptual Framework"One of the tools that shows the greatest immediate promise is the computer, when it can be harnessed for direct on-line assistance, integrated with new concepts and methods." (Douglas Engelbart 1962 - Bootstrap Institute) Posted on September 11, 2001 | Permalink The Computer 'Revolution' Hasn't Happened Yet!"Alan Kay is best known for the idea of personal computing (...)" (EDUCOM'98) Posted on July 11, 2001 | Permalink 'Seven Issues' Revisited"(...) the slides from this landmark talk on the web." (HT'91 Keynote - Frank Halasz / RealVideoStream) Posted on July 20, 2000 | Permalink |


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Open AccessThis article is
- freely available
- re-usable
Pharmaceuticals 2013, 6(2), 269-286; doi:10.3390/ph6020269
cGMP-Dependent Protein Kinase Inhibitors in Health and Disease
Department of Pharmacology and Toxicology, Institute of Pharmacy, University Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany
* Author to whom correspondence should be addressed.
Received: 20 December 2012; in revised form: 23 January 2013 / Accepted: 5 February 2013 / Published: 7 February 2013
Download PDF Full-Text [735 KB, uploaded 7 February 2013 09:12 CET]
Abstract: cGMP-dependent protein kinases (PKG) exhibit diverse physiological functions in the mammalian system e.g., in vascular and gastrointestinal smooth muscles, in platelets, in kidney, in bone growth, nociception and in the central nervous system. Furthermore, PKG were found in insects and in the malaria parasite Plasmodium falciparum. Two different genes of PKG exist: a) the PKG-I gene that is expressed as cytosolic PKG-Iα or PKG-Iβ isoform, and b) the PKG-II gene, which expresses the membrane associated PKG-II protein. The enzyme kinetics, the localization and the substrates of these PKG enzymes differ utilizing different physiological functions. Various inhibitors of PKG were developed directed against diverse functional regions of the kinase. These inhibitors of PKG have been used to analyse the specific functions of these enzymes. The review article will summarize these different inhibitors regarding their specificity and their present applications in vitro and in vivo. Furthermore, it will be discussed that the distinct inhibition of the PKG enzymes could be used as a valuable pharmacological target e.g., in the treatment of cardiovascular diseases, diarrhea, cancer or malaria.
Keywords: cGMP; kinase; PKG; inhibitor
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MDPI and ACS Style
Wolfertstetter, S.; Huettner, J.P.; Schlossmann, J. cGMP-Dependent Protein Kinase Inhibitors in Health and Disease. Pharmaceuticals 2013, 6, 269-286.
AMA StyleWolfertstetter S, Huettner JP, Schlossmann J. cGMP-Dependent Protein Kinase Inhibitors in Health and Disease. Pharmaceuticals. 2013; 6(2):269-286.
Chicago/Turabian StyleWolfertstetter, Stefanie; Huettner, Johannes P.; Schlossmann, Jens. 2013. "cGMP-Dependent Protein Kinase Inhibitors in Health and Disease." Pharmaceuticals 6, no. 2: 269-286.
Published by MDPI AG, Basel, Switzerland
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Hopping club to club mainly throughout Lower Manhattan, N.Y., save for a handful of shows in Brooklyn, is the only way to absorb the CMJ Music Marathon's seemingly endless array of music. And if not taken in stride, one might easily fade before the finish line.
While Mulberry Mountain could have technically been described as a disaster area, Wakarusa 2013 ended on a high note with incredible performances in an incredible atmosphere.
The 7th annual Grove Fest took place on Saturday, October 6 in the Grove neighborhood of St. Louis and featured an array of local music, interactive art, street performances and local food and drink. It was definitely not limited to that, however.
After a rainy Saturday the Big Muddy Blues Festival moved outside for Sunday, the festival's final day.
An uninvited guest, Hurricane Isaac, forced all of Saturday's music at the Big Muddy Blues Festival inside.
Are you ready to storm the castle? Thousands of people are gearing up for the Forecastle Festival in Louisville, KY -- taking place July 13th-15th -- and we want to send you and a friend!
Hat tip to A to Z, but the big summer festival in Forest Park is back with a swell lineup.
Thursday, October 21, 2010
Jaill at the Studio at Webster Hall
Before starting their set, the singer warned the audience in advance that the band had just eaten falafel and so no one should stand too close to the stage. The set started a little rough, but Jaill had won the crowd over by the end as the energy and songs got better as the set drove along.
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CENTERBURG — The Centerburg school board on Monday voted to implement a reduction in force due to financial reasons. The board eliminated one seventh- to 12th-grade math position and one sixth- to 12th- grade physical edcucation position. As a result, the contracts of math instructor Michelle Ball and physical education teacher Ami Stevens were suspended. Treasurer Ellen Scott told the News on Tuesday fine-tuning the scheduling with the reductions is expected to make the best use of the remaining teachers.
The board considered, then tabled, a proposal to eliminate the family and consumer science program. Scott said some students and a couple of parents were at the meeting to speak in favor of keeping the program.
Scott said the district's financial outlook is bleak but controllable at this point. "Due to our reaction to the fiscal crisis," she said, "we have managed to make some cuts and should end up the year just about breaking even. It's not going to continue that way. We're still in deficit spending, but we do have a balance at this time.'
Besides accepting the resignation of high school principal Mark McDaniel, the board accepted letters of resignation from Lori Lybarger as middle school student council adviser, first-grade teacher Shelly Arnold and middle school/high school music teacher Mary Beth Lee.


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Veterans from VFW Post 6787 are grateful for the fundraising efforts of Pauline Cordua. From left: Ted Cordua, Marty Arnold, Pauline Cordua, James Clendening and Don Hyatt. Sequim Gazette photo by Mark Couhig
Sequim Gazette staff
Ted notes Pauline isn't a latecomer to the idea of helping servicemen. In World War II, Pauline was one of America's Rosie the Riveters — the women who worked in America's factories manufacturing the armaments needed by the boys overseas. Pauline worked through the war in Benecia, Calif., building howitzers and their shells.