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Traders weren't overly concerned about the Bloomberg breach...yet.
The news highlighted concerns about privacy and data security, but interviews with half a dozen Bloomberg clients suggest that they are willing to overlook what appears to be a relatively minor breach.
"It's going to take a day or two for people to digest this," said the director of trading at a small Wall Street firm, who like others interviewed for this article, asked not to be named because he subscribes to Bloomberg. "But I don't know of anyone, from a user perspective, that's been taken aback."
Bloomberg Editor-in-Chief Matthew Winkler called the long-standing practice "inexcusable," but said the information reporters were able to see was "limited."
Winkler said reporters were able to see three different types of information: login history, "high level" data via function keys (not actual keystrokes), and help desk transcripts.
Not a big deal for now: The login issue seems to have been the least offensive transgression. Reporters could see when a login was created and how often a user logged in.
All Bloomberg users have the ability to see when another user is logged in via the network's instant messaging service, one trader said. Users also have the option to hide their login status.
Related: Private equity firms 'concerned' about Bloomberg snoop
A bigger concern: Traders were more troubled by the possibility of reporters being able to track their activity by what function keys they used.
Bloomberg reporters could see "high-level types of user functions on an aggregated basis, with no ability to look into specific security information," said Winkler. He compared it to being able to tell whether someone had accessed Microsoft Word or Excel on their PC.
The function keys are used to navigate the Bloomberg system, including to execute trades.
Winkler stressed that reporters never had access to those systems or other sensitive tools. They could not see messages clients sent to each other and could not tell what stories users were reading.
Still, the idea that reporters were able to monitor what users were doing, even in a broad sense, made some traders uncomfortable.
"If it's limited to login history, then that's benign enough that this all goes away," said one investment strategist. "If it turns out that they had access to other information, that's another story."
Helpdesk transcripts: Bloomberg reporters could also glean information by looking at transcripts of conversations clients had with the help desk.
It's possible that some sensitive information may have been disclosed in these transcripts, one user said, "but that's pure speculation at this point."
Related: Goldman catches Bloomberg reporters spying on terminal users
Few alternatives to Bloomberg: Overall, traders see the Bloomberg service, for which they pay $20,000 a year, as an essential tool. In addition, the company has pledged to wall off the news gathering operation from the data providing business.
"Bloomberg is so omnipresent on desks here and internationally," said another New York-based money manager. "It's a trusted name, but obviously they have some housekeeping to do."
Index | Last | Change | % Change |
Dow | 16,340.08 | -11.17 | -0.07% |
Nasdaq | 4,323.33 | 16.14 | 0.37% |
Treasuries | 2.73 | -0.04 | -1.45% |
Company | Price | Change | % Change |
Bank of America Corp... | 17.28 | 0.01 | 0.06% |
General Motors Co | 34.86 | -0.32 | -0.91% |
Verizon Communicatio... | 46.36 | -0.34 | -0.73% |
Pfizer Inc | 31.98 | -0.44 | -1.36% |
Cisco Systems Inc | 21.82 | 0.21 | 0.97% |
Overnight Avg Rate | Latest | Change | Last Week |
30 yr fixed | 4.34% | 4.33% | |
15 yr fixed | 3.38% | 3.34% | |
30 yr refi | 4.35% | 4.32% | |
15 yr refi | 3.36% | 3.32% |
Today's featured rates:


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Plugin Categories
View All Plugins Effects & Others (14 plugins) Contrast & Luminosity (8 plugins) Black & White (5 plugins) Color Enhancement (4 plugins)Uniquely Powerful Plug-ins
AfterShot Pro includes the industry's most advanced, best integrated plug-in interface, providing photographers with unique, totally non-destructive access to third party image editing tools.
Plug-ins in AfterShot Pro are no different than the built-in adjustment tools - all tools and plug-ins work seamlessly with AfterShot Pro's undo/redo and editing History tools, may be applied or changed in any order, and don't ever require creating intermediate image files.
zText - Writes text on your image
This plugin enables writing on an image in any font, color, size, opacity, in any perspective view, with shadow effect and more. It also supports text effects like italic, bold underline, etc.
Drawing the date/time of the image shot is possible as well as...
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by: tintin | updated: Feb 5th, 2013 | Clicks: 116232 |
zShadow - Adding a shadow to your image
zShadow is made to add a shadow to your image. Like shown in the examples the shadow could either be applied in a certain direction or around the whole image. Thereby the colors for background and the shadow can be adjusted separately. Also the size of the...
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GradFilter Pro - Graduated Neutral Density and Color Filter
GradFilter Pro simulates graduated neutral density and graduated color filters. The plugin can be used, for example, to darken a bright sky or brighten a dark subject so that both the sky and subject are properly exposed.
Important n...
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by: Roger Barnes | updated: Dec 20th, 2012 | Clicks: 203973 |
zChannelMixer - channel mixer plugin
A channel mixer plug in that supports also direct B&W conversion before or after (or both) mixing the channels....
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by: tintin | updated: Nov 18th, 2012 | Clicks: 67684 |
zFrame - applying up to five frames around your image
This plug-in draws up to five frames around an image. Each frame can be set with different size and color. Also the ratio of the frames thickness on the long and short side might be adapted as well as the image can be moved inside the frame. This offers t...
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subset: commoncrawl


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Buy your favourite cutaways and archive images online now. Thousands of unique aviation photographs available
The nose of Boeing C-17A Globemaster III c/n F-211 with tailnumber 03 (080003). The photo was taken in The Netherlands, as you can tell by the bikes parked against the front wheel. This low country counts more bicycles than people! The aircraft was on display at Leeuwarden air base (EHLW) on 17 September 2011, the second day of the Open Days of the Royal Netherlands Air Force. This Globemaster is one of three of NATO's Strategic Airlift Consortium or Strategic Airlift Capability (SAC) in which 12 countries participate. The aircraft (not surprisingly numbered 01, 02 and 03) are based at the Hungarian Air Base Pápa, as visible on the engine cover.
Related links in this EnoAeroPics media gallery:
Images of the second Battle of the noses
Images of the first Battle of the noses
See more images of the Boeing C-17
See more images of the Open Days 2011 of the Dutch air force
More information:
NATO's strategic airlift consortium
See the most recent EnoAeroPics images on Flightglobal/AirSpace here
See all EnoAeroPics images on Flightglobal/AirSpace here


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Posted 1 year ago
(121 items)
This is one of those things you hear about but never has happened to you...stories! I was out doing my usual treasure hunt on Saturday at the local garage sales. I was looking for some old salts to use as marble holders since I had bought a few shooters to go with the rest I have. I came across this planter filled with banged up, chipped, cracked, tore up from the floor up salts. I figured for $1 I could still use them even in there bad condition until I found something better to use. I ask the gentleman if the planter was included, he said no but that I could have it anyways...I didnt give it another thought until just the other day. Dont get me wrong, I loved the planter with the crazy cool cat on all sides. Well just for fun I went to google images to see if there were any more out there and WHOA!!! The first image to come up was of my planter that sold at Cowan Auctions (Wes Cowan from Antiques Roadshow is the owner) in 2007 for over $80. Im not sure of the true value of the planter only that it was listed as a rare Mckee piece. I was almost ready to put it in the garage for next years sale, whew Im glad I looked this one up! But can you believe it, IT WAS FREE!!!


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OK, if you are searching for the perfect accent chair, look no more because this baby is it! Got it for a steal with super low shipping....but i would have paid full price for this chair! I ordered two chairs and I am so glad that I did. The colors are amazing and assembly is a breeze! I assembled both chairs in about 20 minutes, SERIOUSLY! I know you don't know me, but trust me, this chair is IT!
I wanted to wait until I had had these chairs awhile to write a review to see how they could stand up in the real world. They were kinda a pain to put together with that little tool, but it was fine. We have had them a year and the springs and material have held up extremely well. We sit on them every day and they show no wear & tear. I have had to tighten the bolts once but I figure that is just normal settling in. This was a good, stylish buy!
The color is much more of a gold tone than the picture would indicate. Since the sofa they're to go with is back ordered (from another site) I don't know if it will matter. They assembled easily. They are comfortable. They seem sturdy but I will limit the size person who uses them. I would think anyone more than 250 lbs. might be a little much for them. I bought on sale and only paid $*** for a pair. You can't beat that price. I might rate higher if the color had been right and after I see how they last.
I purchased this chair as extra seating in our family room, I didn't expect much for the $100+ that it cost.....however, it is excellent quality and so... so comfortable. It is masculine enough for my husbands man cave area and I ordered pillows to match to blend it into the sofa I had. Very..... very nice
I did not have any problems. Easy to assemble . Great chair . Love the color.
Easy to assemble, beautiful fabric and very comfortable. Customer Service is fantastic!
I thought these chairs were nice but not quite as bright as the pictures would suggest. Ultimately I decided to return them but not due to any quality issue. Good value for the money if you like the style.
I gave this review a 5 star because the customer service at Overstock.com is absolutely phenomenal!!!!! They exceeded my expectations and then some. I ordered two of these fabulous chairs. My order was delivered in less than a week. I was very happy about that. When they arrived, I did not open the box for a few weeks. I was in the process of moving. Once I opened my shipment, I found the accent chairs were very easy to assemble. I would recommend having a second place just to make sure everything is secure. Assembly too less than 45 mins with two people. One of the legs of my chairs did not fit properly, but I figured I can adjust the holes myself with a drill. I did notify Overstock about this issue. They did ask me to return them free of charge and they would replace the order. After just moving for weeks, I was not in the mood. The lady was very apologetic and then decided to give me a refund for my trouble. I thought this was extremely generous of her. Overall the chairs are extremely comfortable. Everyone who come to my home compliment them and ask where can they find them. The leg problem is now fixed as well. They are true to color and size! Definitely worth buying one or two :-)
If you are looking for stylish budget accent chairs, this would be for you. I wouldn't put these in a high traffic/daily use area. But in my formal area, they look very nice.
These chairs provide very nice quality for the price. They were easy to put together.
Usually leaves our warehouse in 1-2 business days. *
Items must be returned in new or unused condition and contain all original materials included with the shipment. More details
FINAL SALE EXCLUSION: Items marked as FINAL SALE are not returnable unless the problem you experience is the result of our error.
Our standard shipping method is ground shipping. We also offer expedited shipping for most items. Your final shipping cost and estimated delivery timeframe will be available at checkout.
Standard shipping details
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* For your safety, some orders go through our loss prevention department. If we select your order for this process, we will immediately notify you that there may be up to a 3-day delay on your order.
** Most Oversize orders are delivered within 1-4 weeks. Some orders may take 6 weeks to be delivered.


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A signature guide can help you get around the difficulties of signing your name on receipts, cheques and forms.
Many banks now provide free signature guides - usually a credit card-sized piece of plastic with a cut-out rectangular window for you to sign your name within. If your bank won't provide a signature guide, we can sell you one. Our black signature guide is made from a durable plastic and is priced at 45p (ex VAT) and 54p (inc VAT). We also sell a wallet containing both a signature guide and note check (to help you identify different denominations of bank note). Priced £1.35 (ex VAT) and £1.62 (inc VAT), it's available from our online shop or by calling us on 0303 123 9999.
Mrs Jones from Bournemouth suggests a cheap way to identify which way up pension books and chequebooks are. "I use a lot of bump-ons on my computer, cooker and washing machine but they're expensive. When I need to sign cheques or my pension book I have a cheap way to make sure the book is the right way up: I buy sheets of coloured labels from WH Smith. You get about 500 in a pack and stick them in the bottom right-hand corner of the book then I can feel for the label when I come to use the book. I also find them indispensable to find side one of an audio tape." RNIB can sell you single sheets of 56 bump-ons, all of the same shape and colour, or a pack of mixed shape bump-ons (DL42) which contains seven round yellow bump-ons, six square black bump-ons, seven large dome head clear bumpons and six small dome head clear bump-ons - available from RNIB's Online Shop or call RNIB on 0303 123 9999.
Hugh Dorrian from County Down had this to add: "I get the post mistress to cut the top right hand corner off my new pension books, so I know when it is facing me the top corner is cut off."
Contact: email@example.com
Last updated: 19 December 2012
Right now we can only reach one in three of the people who need our help most. Please make a donation and help us support more blind and partially sighted people.


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If you've looked through the posts on my blog, you'll probably have already gathered that I sew rather a lot and that this blog is all about that stitchery and the life that goes on around it (or should that be the other way around...sometimes it can be hard to get one's priorities right). I sew mostly clothing and quilts.
So anyway, about me: I live in England, I'm 36, I have two small children who aren't actually so very small any more and I am married to the delectable Mr Teacakes, who works alongside me from home (we design educational apps for iPad, iPhone and android devices to help children learn their weekly spellings, times tables, fractions and lots of other essential skills).
I try to sew nearly every day. I write patterns and occasional articles for sewing magazines, as well as sharing tutorials here on my blog. Oh, and I've also produced an eBook all about machine applique. And when I'm not doing any of those things then I can be found looking floury in the kitchen where I love to bake.
I made my first bag at primary school: big hoop handles, reversible fabric and stitched by hand, created in the peace and tranquillity of a classroom half full of girls (the boys having been sent out to perfect their cricketing skills) and I have been hooked ever since. My even earlier happy memory of knitting squares for donkey blankets for the PDSA in my first year at school is only marred by the subsequent knowledge that it must have resulted in a chilly burro, for even now knitting and crochet foxes me to the point where I have had to lay down the needles and hooks and promise myself not to pick them up again.
It's too hard to choose what is my favourite area of sewing, for there's a sewing task to suit every mood, but dressmaking, quilting, applique, and bag making are all somewhere high up on the list.
Most recently, I have developed an utter obsession with English paper piecing: that is, creating more intricate quilt tops sewn entirely by hand. It's wonderfully liberating not to be bound to the sewing machine and for sewing to suddenly feel a much more sociable and portable activity (in fact you can find my own beginners guide for getting started with English paper piecing here).
I absolutely love reading the comments that so many lovelies take the time to leave. I try to reply in the comments section as Blogger often doesn't supply a reply email address...and also because inbox management isn't my strong point and so it's just easier that way. But if you want to contact me directly then you can find me at flossieteacakes (at) gmail.com.
Thank you so much for reading,


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340 East 55th is a charming walk up building between 1st and 2nd Ave in the heart of Midtown East. This building is close to 4, 5, E, M, N, R, Q, 6 Subway station.
Apartment Features and Amenities o Granite countertops
o Stainless steel appliances
o Marble bathrooms
o Washer/Dryer
o Recessed lighting
o Crown and baseboard molding
o Hardwood flooring throughout


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FREE Email Newsletter
Test System Measures Passive Intermodulation
April 4, 2008 6:37 am | CommentsBoonton, a Wireless Telecom Group company, introduced its PIM 20 ultra portable test system for passive intermodulation. Its design provides a rugged, reliable tool for RF field technicians. The device is battery-driven and self-calibrating. When connected to a component or system, users can read the measurement value (dBc) directly from the display, follow the LED bar that turns red if too high of a PIM value is measured, or they can connect it to a device like a Walkie-Talkie to listen remotely if PIM values change when altering components (e.g. tap test).
LED Lightpipes Prevent Color Mixing
April 4, 2008 6:33 am | CommentsUsing optional barriers that prevent color mixing from adjacent rows Elma Electronics' LED Lightpipes provide distinct color output. The lightpipes have thin polycarbonate barriers which are configurable, block intruding light from other tube lanes, and add strength; resulting in clear, segregated color definition. The lightpipes offer the flexibility to have barriers between some or all of pipes, allowing the ability to mix and match.
High Accuracy Resistance Temperature Detector Simulator
April 4, 2008 6:31 am | CommentsPickering Interfaces introduced its Model 40-262 high accuracy resistance temperature detector simulator that is an 18-channel variable resistor module designed to simulate the operation of PT100 and PT1000 RTDs with resolution and accuracy in the PXI form factor. The detector provides an accuracy of more than 0.1 percent for all resistance settings, allowing RTDs to be simulated with accuracy. It uses a design principal that combines fine and coarse control mechanisms in combination with a calibration system to achieve its performance.
Power Monitor Measures Current and Voltage
April 4, 2008 6:27 am | CommentsLinear Technology Corp. introduced its LTC4151 high side power monitor that measures current and input voltages from 7V to 80V. The monitor uses an internal 12-bit ADC to continuously measure both high side current and input voltage to give a true power reading. It replaces prior units that use costly current sense amplifiers with a separate ADC, a hot-swap controller with an ADC, or an ADC with a floating ground.
Precalibrated Position Sensor Serves as Potentiometer Replacement
April 4, 2008 6:16 am | CommentsMacro Sensors introduced its LP750 series position sensors that are hermetically sealed, frictionless, and they can serve as long-life replacements for failing potentiometers in a range of industrial position measurement applications such as machine tool positioning, hydraulic cylinder positioning, valve position sensing and automatic assembly equipment. Offering frictionless position feedback similar to the potentiometer, these sensors have no parts that wear out, offering unlimited cycle life and greater performance than a potentiometer.
Vision Sensors Perform in Complex Inspection Applications
April 4, 2008 6:10 am | CommentsPepperl+Fuchs introduced its Model VOS300 series vision sensors that combine a camera, illumination, digital outputs, process data and five evaluation methods into a single, rugged sensor housing. The result is an out-of-the-box vision sensing system that is easily configured without programming knowledge and operated without the need for detailed image processing experience. The sensors deliver advanced functionality in a number of complex inspection applications where traditional photoelectric sensors are unsuitable for use.
Guide Details Sensing Systems for Process Control
April 4, 2008 6:05 am | CommentsAutomation Products Group, Inc. (APG) released its Guide to Ultrasonic and Level Sensors that details the company's ultrasonic, liquid level and solid level sensing systems for process control. Each product section includes a full operational description, list of potential applications, detailed specifications and dimensions, and ordering information.
High Resolution Analog Output Encoder for Harsh Environments
April 4, 2008 5:57 am | CommentsMicronor, Inc. announced its ENA361M (hollow shaft) and ESA361M (solid shaft) series ruggedized high resolution analog output absolute encoders that provide 12-bit resolution with a choice of analog output for high reliability industrial automation and process control applications. These single-turn absolute encoders are offered with a choice of 4 mA to 20 mA or 0V to 10V output, and measuring range options of 45°C, 90°C, 180°C or 360°C.
Dual Output Drawworks Encoder for Oil Field Applications
April 4, 2008 5:49 am | CommentsBEI Industrial Encoders introduced its dual output drawworks HS35 encoder for oil field applications that combines rugged, heavy-duty features into a through-shaft style for use as a winch-turns counter in the drawworks system of oil rigs. The encoder can supply simultaneous position feedback to two separate systems from a single encoder. The hard-anodized metal housing, sealed connector, IS rating, dual bearings and shaft seals for NEMA 4 and 13 (IP65) ratings combine to provide a rugged encoder that performs in the harsh oil field environment.
Compact Module Is Based on the Intel Atom Processor Z500 Series
April 3, 2008 12:43 pm | Commentscongatec AG added the conga-CA to its COM Express product line. It features the Intel Atom processor Z500 Series and the Intel System Controller Hub US15W. The complete design of this 95 mm × 95 mm, 3¾" × 3¾" sized COM Express module is geared around low power consumption. Typical power requirements for this module will be less than 5W which, when combined with ACPI 3.0 battery management, ultra mobile embedded applications
Solid State Lamp Challenges T-8 Fluorescent Tubes In Large-Scale Refrigerators, Freezers
April 3, 2008 11:58 am | CommentsAmerican Bright Lighting's UL Listed (UL file number E315644) SimpleTube LED replacement lamp is presented as being capable of replacing T-8 fluorescent tubes in large-scale retail refrigerators and freezers. According to the company, independent laboratory testing performed
Synchronous Buck Regulator Features Built-In Sequencing
April 3, 2008 11:45 am | CommentsMicrel, Inc. introduced its Model MIC22400 fully integrated 4A synchronous buck regulator for powering systems from 3.3V and 5V supply rails. With operating frequency programmable from 800 KHz to 4 MHz, it features built-in sequencing, tracking and ramp control, enabling all power-up sequencing and tracking protocols. Targeted at the communications, computing peripherals and high-end consumer markets, the regulator is suitable for servers/routers, HD DVD recorders, wireless base stations, FPGAs, DSPs and low voltage ASICs. The regulator features fully integrated 60 m? P-FET and 35 m? N-FET switches that deliver a 4A output current with an input voltage range of 2.6V to 5.5V.
Metered Power Distribution Units Feature Centralized Configuration
April 3, 2008 11:40 am | CommentsTripp Lite expanded its line of power distribution units (PDUs) to provide options in power capacity, form factor and management. Most of the models feature a proprietary built-in network interface that allows users to remotely monitor and control individual outlets and connected devices via SNMP, Web or Telnet. For greater functionality, free PowerAlert network management software centrally monitors and controls power for up to 250 UPS systems or PDUs on their network. The software allows managers to mass-configure multiple remote device settings from a single location, and they can also be set to auto-discover UPS and PDU devices in specific network segments or IP address ranges.
MOSFETS Target DC/DC Applications
April 3, 2008 11:34 am | CommentsToshiba America Electronic Components, Inc. expanded its power semiconductor line with a family of high-speed switching MOSFETs based on UMOS VI-H which enables a reduction in gate switch charge and on-state resistance (RDS(ON)), resulting in greater power efficiency. The Models TPCA8028-H and TPC8035-H MOSFETs are intended for use in high efficiency DC/DC converter applications in notebook PCs and other electronic applications.
Inverter Provides Power for Cold Start Displays
April 3, 2008 11:29 am | Endicott Research Group | CommentsEndicott Research Group released its E220 series DC/AC inverter that combines up to 12W of output power with a vacuum-encapsulated design to ensure reliable CCF lamp ignition for LCDs used in outside, cold storage or other low-temperature environments. The inverter provides starting voltages of up to 2,300 Vrms in a compact, low-profile, PCB-mountable package for LCDS ranging in size from 5.7"to 15" diagonal. The inverter uses the proprietary EFD 20 low-profile transformer for a form factor of 0.60" × 1.2" × 1.56" in a fully vacuum-encapsulated design that ensures maximum resistance to shock, vibration and humidity. Operating range is -20°C to +70°C.


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Lucky the Leprechaun at Carlo's Bake Shop
Lucky the Leprechaun, an icon of American pop culture and a staple cereal is celebrating 50 days of fun and [...]
Free Cupcakes
If you're looking for a low-key day with your significant other or if you're a big fan of desserts, Joe's [...]
Hailo Boston to have a Kickass birthday, offer free rides and cupcakes
Hailo Boston, an app-based taxi hailing service, will celebrate its first birthday Wednesday by offering free rides and Kickass Cupcakes to customers, according to the company, which on Monday announced its expansion to Brookline.
Taste Test: Magnolia Bakery's Double Shot Cupcake
To kick off their new collaboration with Peet's Coffee & Tea, Magnolia is debuting a Double Shot cupcake.
Carrot sticks vs. Cupcakes
Carrot sticks suck. Cupcakes, on the other hand, rule!
What to see, buy and eat at the 2nd Street Festival
Weird Hot and Banned Books will play the 2nd Street Festival
4 new things we want to eat right now
Eat these new treats this weekend.
Hollis Wilder's 'Savory Bites'
"Cupcake War" two-time champion, Hollis Wilder's new book "Savory Bites" is filled with creative recipes to make in a cupcake pan.
Chadds Ford Winery Cupcakes and Cocktails
Chadds Ford Winery Cupcakes and Cocktails Every Saturday in April, Peddler's Village invites guests to sample assorted wine cocktails, then [...]
Culinary battle at Dish It Up
Women Against Abuse's fifth annual Dish It Up


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text: The USA men's 7s team is in camp with a few changes, as Luke Hume and Peter Dahl are with the USA 15s team, and Mike Palefau is getting settled in a new job. Head Coach Alex Magleby said the team is working hard and making steps toward improvements. "We know it's a process to improve play and change the culture," Magleby told RUGBYMag.com. "But we also know we're in this to win." Back in camp is Colin Hawley after he attended to some personal commitments. He joins captain Shalom Suniula and veterans Zack Test and Matt Hawkins. Also in camp are Brett Thompson, Maka Unufe, Carlin Isles, Mike Te'o, Tai Enosa, and Rocco Mauer, who all played in the Gold Cast 7s last month. Rugby league player Dannny Howard, and former Zimbabwe and South Africa prospect Preston Bryant are in camp – Bryant still coming back from injury. Jack Halalio and Nate Ausgpurger, who played for the USA Falcons at the Serevi 7s, are back in camp, as is Folau Niua, back, finally, from injury.Also in camp is Nick Edwards, who is a proud owner of a US passport, which makes him eligible not only for the IRB World Series (for which he was eligible anyway), but the Olympics. Andrew Durutalo, Blaine Scully, and Taylor Mokate are in camp but on limited activity as they come back from injury. Saturday the team attended a fundraiser and barbecue for Ronan Nelson, a young player from Southern California who broke his neck playing rugby this past spring. The event was to raise money for treatment costs not covered by insurance. To donate, see this link. https://www.wepay.com/donations/team-ronan-a-bbqfundraiser-benefiting-the-team-ronan-recovery-fund


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The Georgia Department of Labor will help Home Depot fill a number of jobs.
The recruitment for Home Depot is set for Thursday from 10 a.m. to noon at the GDOL's Cobb-Cherokee Career Center, located at 465 Big Shanty Road in Marietta. The company will be recruiting for bilingual supervisors who are fluent in both Spanish and English.
Applicants must have a high school diploma or a General Education Diploma (GED) and have at least one year of supervisory experience. Applicants will be required to apply online at the recruitment unless they have already applied at http://careers.homedepot.com/?HDCAREERS&view.
Salaries are in the $12/hour range, depending on experience.


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With help from their sons, friends, and colleagues, lifelong restaurateurs Rob and Kelly Kukura opened 95a Bistro & Sushi in 2011, winning nearly instant acclaim from Boulder Magazine. The menu draws inspiration from Latin, Mediterranean, and Asian cuisines, showcasing hot and cold tapas such as bacon-wrapped dates and beef carpaccio along with entrees of brie-covered vegetable gnocchi and scottish salmon flavored with smoked-paprika brown butter. Their wide selection of sashimi and nigiri-style sushi includes the Firecracker specialty roll, whose fillings of citrus-aioli-topped crunchy tuna can be heard all the way down the street. The restaurant serves its brunches, lunches, and dinners both inside and on a seasonal outdoor patio overlooking a sprawling lawn.
Kira Sushi chefs bring years of experience to crafting specialty maki and handrolls, and insist on using only the freshest ingredients to complete each roll. The menu encompasses more than 30 types of sushis and more than 60 types of rolls. Lobster salad and spicy tuna pair with seaweed salad and crab meat to make the Disney, one of the restaurant's trademark specialty rolls. Fresh sashimi, teriyaki, and noodle dishes complete the eatery's offerings of tasty Japanese dishes.
In order to consistently impress guests, the chefs at Hana Matsuri work closely with fish markets to procure the freshest seafood for their sashimi, nigiri, and maki creations. Once their grocery baskets are filled, they head to the kitchen to start rolling rice around interesting ingredient combinations such as the Hamachi Orange roll's mix of spicy shredded yellowtail, orange wedges, masago, jalapeño, and mango sauce. Beyond the sushi bar, the chefs create an array of hotter Japanese dishes—including steaming udon soups and teriyaki meats—for lunch and dinner.
"ZEN," reads the letters attached to the dining room's wall. Calming green walls and the occasional potted tree serve as soothing design elements. Modern hanging lamps float above diners' heads, suspended from the matte-gray piping that lends the dining room a subtly industrial-chic look. It's in this invigorating space that diners get excited about the memorable culinary quests they're about to embark on. One end of the room is striped with a sushi bar, but patrons can also order rice-swaddled fillets at their tables. Those looking to snap up something different peruse a more general menu influenced by Vietnamese, Thai, Chinese, and Japanese cuisine.
At Ooka Sushi, the chefs satisfy practically any Asian-cuisine craving, not just those for artfully prepared and presented sushi and sashimi. They also slow cook broccoli and bell peppers in a thick Thai peanut curry, marinate duck meat in Chinese fire spices and fry it to a golden crisp, and deep fry shrimp in tempura batter.
Every sushi fan has a fantasy roll—a picture-perfect masterpiece that's comprised of a flawless melange of traditional and inventive ingredients. The chefs at Sushi Yume are no exception. For their fantasy roll, they delicately wrap shrimp tempura, avocado, and tobiko in crisp sesame soy paper before drizzling it with sweet-and-salty eel sauce. The fantasy roll is just one of the menu's 30-plus specialties, whose fixings range from the Rocky Mountain roll's cream cheese tempura to the Hawaiian roll's dusting of wasabi pea powder.
While sushi chefs handcraft their orders, Sushi Yume's other cooks whip up Japanese staples such as scallop teriyaki and grilled eggplant doused in miso sauce. The culinary teams combine their efforts for lunch and dinnertime bento boxes, which pair mains and sushi selections with a California roll. Handcrafted cocktails complement feasts, as does a selection of Japanese beers, sodas, and hot or cold sakes.


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Blake Griffin the Posterizer
The dunk heard around the world. Staples Center has displayed an array of highlights in a pivotal game for the Clippers to show how well they contend with the best in the West against the Oklahoma City Thunder. Unfortunately if you live on the Least Coast, you may not see the play until tomorrow, since it would have been after midnight. High riser Blake Griffin absolutely posterized Kendrick Perkins by elevating over him and throwing it down emphatically. Perkins remained in disbelief, as were everyone else viewing from afar. Buzz has spread through the internet and on Twitter. Many current players have tweeted about the play being the best dunk they have ever seen. If you do not believe them, see for yourself. Lob City will knock off OKC 112-100.
Tags: Blake Griffin, Kendrick Perkins, Los Angeles Clippers, Oklahoma City Thunder


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Copyright © 2009 Elsevier Inc. All rights reserved.
Molecular Cell, Volume 34, Issue 5, 545-555, 12 June 2009
Add/View Comments (0)Potent Transcriptional Interference by Pausing of RNA Polymerases over a Downstream Promoter
Adam C. Palmer1, 2, Alexandra Ahlgren-Berg1, J. Barry Egan1, Ian B. Dodd1 and Keith E. Shearwin1, ,
Corresponding author2 Present address: Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
- Elongating RNA polymerases (RNAPs) can interfere with transcription from downstream promoters by inhibiting DNA binding by RNAP and activators. However, combining quantitative measurement with mathematical modeling, we show that simple RNAP elongation cannot produce the strong asymmetric interference observed between a natural face-to-face promoter pair in bacteriophage lambda. Pausing of elongating polymerases over the RNAP-binding site of the downstream promoter is demonstrated in vivo and is shown by modeling to account for the increased interference. The model successfully predicts the effects on interference of treatments increasing or reducing pausing. Gene regulation by pausing-enhanced occlusion provides a general and potentially widespread mechanism by which even weak converging or tandem transcription, either coding or noncoding, can bring about strong in cis repression.


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Huntington named a 'great school at a great price'
Huntington, Ind.—In addition to being ranked No. 7 among the Midwest's "Best Baccalaureate Colleges" by U.S.News & World Report, Huntington University also has been named No. 5 among the best values in baccalaureate colleges in the Midwest.
The "Great Schools, Great Price" ranking is based on the percentage of students receiving need-based grants, the average cost of tuition after receiving those grants and the average discount from the total cost.
Additionally for 2009, U.S.News included Huntington on its list of top schools with students representing the greatest economic diversity.
"This is Huntington University's second consecutive year on the 'Great Schools, Great Price' list as a result of intentional strategies on our campus," said Jeff Berggren, vice president of enrollment management and marketing. "One is to continue to increase the academic value that comes from a Huntington education, and the second is to try to moderate the cost incurred by all of our students."
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FORBES ranks Huntington among Top 100 Colleges
Princeton Review lists HU among "Best in Midwest"
In January, the Huntington University Board of Trustees approved a 4.5 percent increase for full-time traditional undergraduate tuition and fees in 2008-2009, making the tuition and fees rate $20,300 annually. Across the United States, the average tuition and fees at four-year private institutions in 2007-2008 is $23,712, representing a 6.3 percent increase of more than $1,400 over 2006-2007, according to College Board's 2007-2008 Annual Survey of Colleges.
"The cost component has been a result of working hard as a campus to keep recent tuition increases below the average for other colleges and universities, impacting the sticker price while also offering increased financial aid to positively affect the net price that students actually pay to attend Huntington," Berggren said.
Approximately 90 percent of Huntington University students receive financial aid in the form of scholarships, grants, loans or work-study assistance.
"I hope that Huntington's listing as both a top 10 'Best Baccalaureate College' and a top five 'Great School at a Great Price' will result in more families seeking a high quality, Christ-centered education considering us as part of their college selection process. The fact we also have been recognized with recent high rankings from Forbes and the Princeton Review only should add to the value perception of Huntington University," Berggren said.
Taylor University was ranked third in the "Great Schools, Great Price" category, followed by Franklin College at No. 6.
Classes began for Huntington University students today.
All U.S.News rankings appear on the magazine's Web site (www.USNews.com). College-bound students can use the site to search for colleges and universities according to their own interests, fill out interactive worksheets and search for scholarship and financial aid information. The America's Best Colleges newsstand book and the weekly edition of U.S.News & World Report magazine (containing many of the rankings) both went on sale Friday.
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Ashland, OR (July 12, 2013) – SAG-AFTRA today announced it has reached an agreement with audiobook producer BeeAudio. The BeeAudio deal is the latest in a series of efforts by SAG-AFTRA to enhance its organizing reach in the area of audiobooks.
In November of 2012, SAG-AFTRA issued "Do Not Work Notice" against the Ashland, Oregon based company that was producing books for various major publishers paying half or less than half the industry standard rate to narrators.
In recognition of the July 4th holiday, SAG-AFTRA offices will be closed on Thursday, July 4 and Friday, July 5. Offices will re-open on Monday, July 8.
Happy Independence Day!
San Francisco, CA (June 11, 2013)– Newspersons represented by SAG-AFTRA at KRON4 voted unanimously last Friday to reject the latest contract offer proposed by KRON4/Young Broadcasting management. SAG-AFTRA members cited equitable compensation, threats to job security, and health/retirement benefit concerns as their primary reasons for rejecting the Company's latest offer. SAG-AFTRA has been negotiating with the Company for over a year while Newpersons continue to work with a contract that expired on April 30, 2012.
New Three-Year Commercials Contracts Effective Retroactive to April 1, 2013
SAG-AFTRA joins family, friends and co-workers in mourning the loss of The Young and the Restless star Jeanne Cooper, a pioneer in the world of daytime drama.
The Screen Actors Guild Foundation is now accepting short film submissions and web series from all states west of the Mississippi for its August 2013 Short Film Showcase. Submissions must be postmarked by Monday, June 3. All entries postmarked after that date will be placed in contention for the Foundation's April 2014 event.
There is no entry fee, nor is there a cost to attend the screening, which is held in Los Angeles, twice a year.


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Acquiring Title to Crown Lands
Natural Resources
Possessory Title is a method of acquiring title or right to land that has been occupied for a statutory period of time as defined by law, under specific conditions.
If the applicable time and occupation requirements are met, you can submit a claim, in writing, to the Crown Lands Branch-Land Use Application Service Centre.
There are two time periods that apply.
• Sixty years for land that is ungranted.
• Twenty years for re-conveyed land.
Ungranted land: the ownership was always vested with the Crown.
Reconveyed land: the land was once granted by the Crown but ownership was subsequently returned to the Crown.
The occupation of the land must be open, visible, uninterrupted and exclusive for the applicable period of time.
Fee Description | Rate in $ | Effective Date YYYY-MM-DD | |
Application fee | 300.00 | 2010-09-22 | |
Preparation fee (if grant/deed issued) | 200.00 | 2012-03-05 |
Contact | Location | |


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Wholesale and Volume Pricing: Sullivan Uniform is a independent wholesale distributor of Red Kap, Bulwark, and Chef Designs occupational work apparel. Our wholesale or Volume prices are an additional savings to our already discounted low prices. You can view the entire Red Kap or Bulwark product line shown at the bottom of this page. Contact our customer service department either by email or at 800-978-4550 for details.
Wholesale Price Quotes: Just follow the three steps below. Simply request a wholesale work clothing quote for the products needed, a Wholesale Account can be easily set up, and Credit Terms are available for qualified resellers. Specify the item, color, and quantity needed. We will be happy to provide you a wholesale quote on discount uniforms.
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Unique Handmade Tiger Eye Jewelry Tiger Eye Necklaces, Rings, Bracelets, Anklets and Earrings Tiger eye is quartz that contains luminescent silica bands that glow in the light giving it the appearance of a tigers eye . Roman soldiers wore tiger's-eye for protection in battle. Tiger Eye was thought to be all seeing due to its appearance. Tiger eye relieves high blood pressure. Tiger eye jewelry is very helpful in the presence of following diseases: bronchial asthma , kidney problems , rheumatic heart disease, otitis and psoriasis. Tiger Eye is used for focusing the mind. It is said that Tiger Eye offers protection during travel, strengthens convictions and confidence. This very warm stone is beneficial for the weak and sick. Tiger eye is a wonderful gemstone for causal fashion jewelry, it just seems proper to wear it with jeans and black leather.
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Oceanfront Tanning Beach and Private Pier
See what's happening right now at the pier.
Searching for that perfect view of the Atlantic Ocean? Look no further. On America's only Caribbean Island, the Southernmost on the Beach offers you a front row seat to daily sunrises and winter sunsets from a different perspective than Mallory Square. Soft sand under your toes, the beachside Sand Bar, and games for the kids and the young at heart, the oceanfront tanning beach and private pier area offer you that piece of paradise you and your family have been longing for. See things on the quieter end of Duval St.


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Ring In the Holidays Lowcountry Style with Nights of a Thousand Candles
By Kimberly Duncan
In the South's winter months, temperatures often somersault from mild 60s upward to 70 and 80-degree temperatures – up and down and back again. Consequently, some find it difficult to catch the holiday spirit. For a surefire shift into holiday mode, don't miss Nights of a Thousand Candles at Brookgreen Gardens. It's long been a treasured tradition among locals — and there is no more surefire sign of success.
Celebrate the season during Nights of a Thousand Candles, December 5-7, 12-14, and 19-21 from 3 – 10 p.m. After sunset Brookgreen Gardens quite literally comes to life thanks to the glimmering of nearly 6,000 hand-lit candles, countless sparkling lights and luminaries that light garden paths, fountains and the twisted limbs of centuries-old oaks. The setting is magical … and then some.
"Every year this event has grown … After last year's record-breaking number of visitors, we knew we needed to add more nights. This year, we are open Thursday nights all three weekends of the event," said Bob Jewell, Brookgreen president and CEO. "We've added new lights and decorations to keep the event fresh, but repeat visitors will see some of their favorite displays again."
During the event, guests can ramble through the sculpture garden and view beautiful lighting displays. They will hear hand bells ringing, carolers singing and see candles drift quietly in the fountains. An extensive array of musical performances will be held throughout the gardens and on the final weekend Bill Oberst, Jr. (Google this guy; he's world-renowned!) returns with his one-man rendition of Charles Dickens' A Christmas Carol.
All entertainment is included in admission. Dinner is available at an additional cost. More than 50 acres of the gardens are open to the public.
In December, adult tickets are $16 and children are $8; Brookgreen individual and family members' pricing for adult tickets is $12 and $6 for children (Helpful hint: this alone is a good reason to buy an annual membership!). All children age 3 and under are free. (Tickets are non-refundable, unused tickets are considered a donation to Brookgreen.) For group pricing of 15 guests or more, please call 800.849.1931 or 843.235.6021. If you wish to have tickets mailed, your order must be received by the end of November.
Brookgreen Gardens, a National Historic Landmark, is located on U.S. 17 between Myrtle Beach and Pawleys Island, South Carolina. All ticket proceeds go to support Brookgreen Gardens, a 501(c)(3) non-profit organization whose mission is to preserve and display American sculpture and regional plants, animals, and history.


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Broccoli and Cheese Soup
This classic combination of flavors lends itself well to this simple, creamy soup. By cooking the broccoli just right, the soup retains a vibrant bright green color. Serve this as a starter to any meal or with a sandwich or salad for a complete meal. So good for you, too.
Prep time: 20 minutes Cook time: 15 minutes Total: 35 minutes
1. Heat the olive oil in a 6-quart stockpot over medium heat. When it is hot, add the onions, garlic, salt, and cayenne pepper. Sauté until the onions are soft and translucent, 4 to 5 minutes.
2. Add the chicken stock and bring to a boil. Once the stock is boiling, add the broccoli and cook until fork-tender, about 5 minutes.
3. Remove the soup from the heat and let it cool slightly. Then puree the soup, in batches, in a blender, adding the cheese in three additions while blending (see Note). Adjust the seasoning if necessary, garnish with croutons if desired, and serve hot.
Note: Please use caution when blending hot liquids; blend only small amounts at a time, with the blender tightly covered and a kitchen towel held over the top.
Yield: 1 1/2 quarts, 4 to 6 servings
- 2 tablespoons olive oil
- 1 1/2 cups thinly sliced yellow onions
- 1 tablespoon sliced garlic
- 1 teaspoon salt
- 1/4 teaspoon cayenne pepper
- 5 cups chicken stock or canned, low-sodium chicken broth
- 4 cups broccoli florets
- 1 1/2 cups (6 ounces) shredded medium sharp cheddar cheese
- Simple Croutons, for garnish (optional)


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U.S. officials are investigating terrorism concerns after two people listed as passengers on the missing Malaysia Airlines jetliner turned out not to be on the plane and had reported their passports stolen.
- video Desperate wait for families after jet vanishes
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White Rabbits
At first, it's easy to mistake the White Rabbits for just another set of New York City dance-rock hipsters in the Clap Your Hands Say Yeah tradition, but a second look reveals a quirkier and more rewarding aesthetic. A sextet featuring two drummers and a piano player, the White Rabbits refer to their music as "honky tonk calypso," and their cheerful blend of calypso, reggae and ska rhythms, plus secondhand music hall influences and big pop hooks, strongly recalls vintage Madness circa "Our House" and the moodier, more experimental side of the Specials and Fun Boy Three, via Ted Leo & the Pharmacists. The White Rabbits began in Columbia, MO, in 2004, when college students Greg Roberts and Stephen Patterson bonded while working at a local record store. Moving to New York in 2005, Roberts (vocals and guitar) and Patterson (vocals, piano and percussion) fleshed out the White Rabbits with guitarist Alex Even, bassist Adam Russell and dual drummers Matt Clark and Jamie Levinson. Signing with Say Hey Records in the U.S. and Young Turks Records in Great Britain, the White Rabbits connected with hot New York indie producer Chris Zane (Asobi Seksu, Les Savy Fav) to record their debut album Fort Nightly. Preceded by the dramatic first single "The Plot," Fort Nightly was released in the summer of 2007. For their second album, the band teamed up with Spoon's Britt Daniel as producer; after recording in early 2009, It's Frightening was released that spring. White Rabbits worked with frequent Spoon collaborator Mike McCarthy on 2012's Milk Famous, who helped the band take its sound in a darker, heavier direction. ~ Stewart Mason, Rovi
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Looking for Purim Mishloach Manot ideas? These examples will inspire you!
Your guide to the perfect traditional hamentashen for Purim!
Making chocolate Babka CAN be easy! Get ready for Purim with this Mishloach Manos favorite by seeing how easy it is.
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Walther Top Point scope.
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You're leaving Wedding Paper Divas to see the Deal of the Day at our parent site, Tiny Prints.
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text:
a place for zinesters - writers and readers
cover of 2013 pocket organizer
art by colin & amara
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Ist preference given to distros and zines. Rates and details are here. Limited space. Very Low Cost!
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Text Browser Navigation Bar: Main Site Navigation and Search | Current Page Navigation | Current Page Content
U.S. Army War College >> Strategic Studies Institute >> Publications >> Schools for Strategy: Teaching Strategy for 21st Century Conflict
U.S. Army War College >> Strategic Studies Institute >> Publications >> Details
Authored by Dr. Colin S. Gray.
All would-be strategists would benefit by some formal education. However, for education in strategy to be well-directed, it needs to rest upon sound assumptions concerning the eternal nature yet ever shifting character, meaning, and function of strategy, as well as the range of behaviors required for effective strategic performance. The author emphasizes the necessity for strategic education to help develop the strategic approach, the way of thinking that can solve or illuminate strategic problems. He advises that such education should not strive for a spurious relevance by presenting a military variant of current affairs. The author believes that the strategist will perform better in today's world if he has mastered and can employ strategy's general theory.
The Chinese People's Liberation Army and Information Warfare
Senior Officer Talent Management: Fostering Institutional Adaptability
Dangerous Ground: The Spratly Islands and U.S. Interests and Approaches
Making Strategic Sense of Cyber Power: Why the Sky Is Not Falling
Categorical Confusion? The Strategic Implications of Recognizing Challenges Either as Irregular or Traditional
Hard Power and Soft Power: The Utility of Military Force as an Instrument of Policy in the 21st Century
After Iraq: The Search for a Sustainable National Security Strategy
The Implications of Preemptive and Preventive War Doctrines: A Reconsideration
Irregular Enemies and the Essence of Strategy: Can the American Way of War Adapt?
Recognizing and Understanding Revolutionary Change in Warfare: The Sovereignty of Context
Transformation and Strategic Surprise
Military Change and Transformation
Military Leadership
Military Strategy and Policy
21st Century Warfare
Military Professionalism


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KELVIN© Magic Pulley
The Updated Magic Pulley™ is Ideal For Classroom Evaluations.
The Magic Pulley™ Measures:
This unique computerized pulley pulls prototypes (land or water) into action. The Magic Pulley™ can accurately measure prototypes or compare moving objects against each other. Use it to illustrate testing and evaluation procedures as it pushes or pulls student-designed prototypes into action.
To begin, students design and construct a basic vehicle out of materials and tools that the teacher provides. Next, they can connect the prototype to the Magic Pulley™ using a cord. One end of the cord goes over the pulley, the other end of the cord is tied to a weight.
As the weight is released, the prototype will travel toward the Magic Pulley™. The sensor sends information to the computer.
Using the included software, record the acceleration rate, velocity, distance-traveled, and time-traveled of prototypes. When the computer is finished making the necessary calculations, 2 detailed graphs will appear on the screen to illustrate the recorded data.
Constructed with a low-friction ball bearing. Does not include mounting stand - teachers can make their own. Has a USB interface to IBM PC. Win '98sp2-XP. Grades 6 to College.
Hand Held?
PC Required?
Battery Powered
AC Power Adapter
Time Display
On PC
Speed Display (MPH or KMH)
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Copyright ® 2013 • KELVIN L.P. Registered trademarks of KELVIN L.P include, but are not limited to: KELVIN®, Kelvin Electronics®, Kelvin Technology™, Hands-On Science®, Build A Better Mousetrap Racer®, Join the Rat Racer®, And the Winner Is…®, New Standards® Modular Labs, and SUMO® Car.


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It is my favorite time of the year! The Off Season gives us a break from racing. It is a time when we can reflect on the past season. I love to look at my swim, bike and run totals for the year. I keep track of all of my workouts and races. So far I have 11 years of the red Jerome running logs
Most people do not have time to put in long training volume. It is not necessary to spend long hours training for races. The majority of triathletes do not
It's been a tough but good winter for my Boston training this year
After a long winter of indoor training, the weather is getting nicer and it is time to be outside training on your bike. It usually takes
Everyone thinks a triathlon has three legs but there are four. It is swim, bike, run and ...
Soon we will be through the challenging winter training season. I can't wait for warmer temps and longer days. There is nothing magical, the key to improving in triathlon is consistant training. That means training through the winter. Sometimes it is easier said than done! The majority of off season winter training should be
The off season is a great time to build strength. Sometimes it is a challenge to fit it in with the swimming, biking and running but well worth the effort. Weight training will
Swimming, biking and running have been a part of my life for several years. I have fallen in love with the triathlon lifestyle and all the good, bad and ugly aspects of it. In the end it is all good in my opinion
Happy New Year! I have set my goals and picked out some my events for the new year. Let the training begin! I do a fair amount of solo training but the group training sessions are by far the best choice! I find myself pushing a little harder while having fun and the time goes by so much faster!
In the pool I am forced to keep up with my lane mates and do the prescribed workout. No slacking on drills either! When there are enough people it is a great chance to practice drafting. I have gotten through many challenging swim
My passion is triathlon, not just training and competing but coaching, teaching and sharing all that I've learned and experienced. I am excited about the 2011 triathlon season and taking everything to a new level!Winter is the time to start planning events and training schedules. The Running Fit Triathlon Clinics and Training Class continue to evolve toward perfection and will have your ready to attack the season. Training classes, the perfect combination, learning and training
Meet Randy
Motivation (Obsession) - Randy's Blog
Meet Mandy
Events - Mandy's Blog
Meet Jane
Training - Jane's Blog
Meet Christi
Swimming - Christi's blog
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Preoperative Cisplatin and Bevacizumab in ER-, PR-, Her-2 Negative Breast Cancer
This study is ongoing, but not recruiting participants.
Massachusetts General Hospital
Dana-Farber Cancer Institute
Beth Israel Deaconess Medical Center
Brigham and Women's Hospital
Information provided by (Responsible Party):
Steven Isakoff, MD, PhD, Massachusetts General Hospital
ClinicalTrials.gov Identifier:
First received: December 20, 2007
Last updated: April 29, 2013
Last verified: April 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The purpose of this study is to find out what effect taking cisplatin in combination with bevacizumab before surgery and then standard chemotherapy plus bevacizumab after surgery will have on participants with ER negative, PR negative and HER-2 negative breast cancer. Cisplatin is used to destroy cancer cells in many types of cancers, and has shown to be effective and have manageable side effects. Bevacizumab is an antibody, which is a protein that attacks a foreign substance in the body. Bevacizumab slows or stops cell growth in cancerous tumors by decreasing the blood supply to the tumors.
Condition | Intervention | Phase |
Breast Cancer |
Drug: cisplatin Drug: bevacizumab Drug: doxorubicin Drug: cyclophosphamide Drug: paclitaxel |
Phase 2 |
Study Type: | Interventional |
Study Design: | Allocation: Non-Randomized Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | A Phase II Trial of Preoperative Cisplatin and Bevacizumab in ER-, PR-, Her-2 Negative Breast Cancer |
Resource links provided by NLM:
Genetics Home Reference related topics:
breast cancer
Drug Information available for:
Doxorubicin hydrochloride
U.S. FDA Resources
Further study details as provided by Massachusetts General Hospital:
Primary Outcome Measures:
- To determine the pathologic complete response rate after preoperative therapy with cisplatin and bevacizumab in ER-, PR-, HER2-negative early breast cancer. [ Time Frame: 2 years ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- To determine the clinical response rate, defined as the number of partial and complete responses, after preoperative therapy with cisplatin and bevacizumab in this patient population. [ Time Frame: 2 years ] [ Designated as safety issue: No ]
- To determine the feasibility and toxicity of administering bevacizumab in combination with standard adjuvant chemotherapy. [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]
- To describe a panel of molecular assays for an association with clinical response and, if feasible, with pathologic complete response in ER-, PR-, HER2-negative subjects treated with cisplatin and bevacizumab in the preoperative setting. [ Time Frame: 2 years ] [ Designated as safety issue: No ]
Estimated Enrollment: | 40 |
Study Start Date: | September 2007 |
Estimated Study Completion Date: | December 2013 |
Primary Completion Date: | December 2010 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Cisplatin/Avastin |
Drug: cisplatin
Preoperatively: Given intravenously on day one of the treatment cycle (once every 3 weeks) for four cycles
Drug: bevacizumab
Preoperatively: Given intravenously on day 1 of the treatment cycle (once every three weeks) for three cycles Postoperatively: Intravenously for four 2-week cycles (once every two weeks) and after the 8 weeks (study doctor will determine course of treatment) for an additional four 2-week cycles with or with out paclitaxel
Drug: doxorubicin
Postoperative: Given intravenously for four 2-week cycles
Drug: cyclophosphamide
Postoperative: Given intravenously for four two-week cycles
Drug: paclitaxel
Postoperative: 8 weeks after postoperative chemotherapy regimen (study doctor will determine course of treatment) paclitaxel for four 2-week cycles (once every two weeks)
Detailed Description:
- To prepare for surgery, a small "clip" will be placed into the tumor area so that the surgeon can locate the site of the tumor at the time of surgery. This is a standard procedure for breast cancer.
- The study drugs will be given in four 3-week cycles (about 3 months). Participants will come into the clinic each day they receive study treatment intravenously. Cisplatin will be given on day one of the treatment cycle (once every 3 weeks) for four cycles. Bevacizumab will be given on day one of the treatment cycle for three cycles.
- On day one of each 3-week cycle a physical exam, routine blood tests and urine test will be performed. 7-8 days after chemotherapy, blood tests and a hearing test will be performed. A preoperative study visit will take place 7-10 days before surgery and a physical exam, routine blood tests, EKG and an MRI of the breast will be performed.
- Surgery to remove the tumor will occur at least three weeks after the last dose of cisplatin and is considered standard of care.
- Postoperative chemotherapy will begin at least three weeks after surgery. Everyone on the research study will receive four 2-week cycles of doxorubicin and cyclophosphamide plus bevacizumab. After the 8 weeks, the doctor will decide which of the following two treatment regimens the participant will receive: Bevacizumab for four 2-week cycles (once every two weeks) or; Paclitaxel plus bevacizumab for four 2-week cycles (once every two weeks).
- At the end of the postoperative chemotherapy, the participant will return to the clinic for a medical history, physical exam, vital signs, performance status, routine blood tests, MUGA or Echo Scans, and a hearing test.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- All tumors must be ER-, PR- and HER2-negative
- Clinical stage T2 or T3, NO-3, MO. Subjects with inflammatory breast cancer are not eligible
- For subjects with clinically negative axilla, a sentinel lymph node biopsy will be performed either up front or after preoperative therapy at the discretion of the subject's physicians; for subjects with a clinically positive axilla, a needle aspiration or core biopsy will be performed to confirm the presence of metastatic disease in the lymph nodes.
- 18 years of age or older
- Performance status of 0 or 1
- Use of an effective means of contraception in subjects of child-bearing potential
- Normal organ function as described in the protocol
Exclusion Criteria:
- Any prior cytotoxic chemotherapy or radiation for the current breast cancer
- HER2-negative ipsilateral breast recurrence, unless prior treatment consisted of excision alone for DCIS or breast-conserving treatment and hormonal therapy for DCIS or invasive cancer
- Life expectancy of less than 12 weeks
- Current, recent, or planned participation in an experimental durg study other than a Genentech-sponsored bevacizumab cancer study
- Renal dysfunction for which exposure to cisplatin would require dose modifications
- Steroid dependent asthma
- Peripheral neuropathy of any etiology that exceeds grade 1
- Uncontrolled diabetes
- History of malignancy treated without curative intent
- Any other pre-existing medical condition that would represent toxicity in excess of grade 1
- Inadequately controlled hypertension
- Any prior history of hypertensive crisis or hypertensive encephalopathy
- NYHA Grade II or greater congestive hear failure
- History of myocardial infarction or unstable angina within 12 months prior to study enrollment
- Any history of stroke or transient ischemic attack at any time
- Known CNS disease
- Significant vascular disease
- Symptomatic peripheral vascular disease
- Evidence of bleeding diathesis or coagulopathy
- Major surgical procedure, open biopsy, or significant traumatic injury within 21 days prior to study enrollment
- History of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 6 months prior to study enrollment
- Serious, non-healing wound, ulcer or bone fracture
- Proteinuria at screening
- Known hypersensitivity to any component of bevacizumab
- Pregnant or lactating
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00580333
United States, Massachusetts | |
Massachusetts General Hospital | |
Boston, Massachusetts, United States, 02114 | |
Dana-Farber Cancer Institute | |
Boston, Massachusetts, United States, 02115 | |
Beth Israel Deaconess Medical Center | |
Boston, Massachusetts, United States, 02115 |
Sponsors and Collaborators
Massachusetts General Hospital
Dana-Farber Cancer Institute
Beth Israel Deaconess Medical Center
Brigham and Women's Hospital
Principal Investigator: | Paula D. Ryan, MD | Fox Chase Cancer Center |
More Information
No publications provided
Keywords provided by Massachusetts General Hospital:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 09, 2014
No publications provided
Responsible Party: | Steven Isakoff, MD, PhD, Massachusetts General Hospital |
ClinicalTrials.gov Identifier: | NCT00580333 History of Changes |
Other Study ID Numbers: | 06-202, AVF36335 |
Study First Received: | December 20, 2007 |
Last Updated: | April 29, 2013 |
Health Authority: | United States: Food and Drug Administration |
Keywords provided by Massachusetts General Hospital:
ER negative PR negative HER-2 negative |
Additional relevant MeSH terms:
Breast Neoplasms Neoplasms by Site Neoplasms Breast Diseases Skin Diseases Bevacizumab Cisplatin Cyclophosphamide Doxorubicin Paclitaxel Antineoplastic Agents Therapeutic Uses Pharmacologic Actions Radiation-Sensitizing Agents Physiological Effects of Drugs |
Immunosuppressive Agents Immunologic Factors Antirheumatic Agents Antineoplastic Agents, Alkylating Alkylating Agents Molecular Mechanisms of Pharmacological Action Myeloablative Agonists Antibiotics, Antineoplastic Tubulin Modulators Antimitotic Agents Mitosis Modulators Antineoplastic Agents, Phytogenic Angiogenesis Inhibitors Angiogenesis Modulating Agents Growth Substances |
ClinicalTrials.gov processed this record on March 09, 2014


text: R. Alan Culpepper holds degrees from Baylor University, Southern Baptist Theological Seminary, and Duke University. He is the founding dean of the McAfee School of Theology at Mercer University in Atlanta, Georgia. Before coming to Mercer, Alan taught New Testament at Southern Baptist Theological seminary and at Baylor University. He has written extensively about the Gospels, and some of his works include The Johannine School; Anatomy of the Fourth Gospel; John the Son of Zebedee: The Life of a Legend;and The Gospel and Letters of John. He is the New Testament general editor of the Smyth & Helwys Bible Commentary series.


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All updates for this rule:
The Department of Labor and Industries is required by law (RCW 51.16.035) to establish and maintain a workers' compensation classification plan. This plan classifies all occupations or industries within the state and sets basic rates of premium that are distributed fairly for these classifications. Department staff determined that a number of rules are in need of revision to ensure the plan is clear and accurate. In an ongoing effort to ease administrative burden for customers and make it easier to do business with the Department, the Department proposes to reformat and simplify language for multiple rules to make them easier to understand and apply. For example, the standard exception classification restrictions are presently addressed specifically in the general reporting rules. Customers must look in two places in the rules to learn what the restrictions are. The Department proposes rewriting each of the standard exception classifications to incorporate the parameters of the reporting requirements into the language of the classification. These changes will not change employer rates or reporting requirements, or classifications. The Department is also reviewing these rules as part of its rules review process under SSB 5679 (Chapter 30, 2013 Laws 2nd Special Session).
The purpose of this rulemaking clarifies that an employer may have more than one classification assigned and the same employees may perform work in multiple classifications. Staff identified inconsistencies in the rules as to when a company may qualify for multiple classifications. WAC 296-17-31017 currently states that in order to qualify for multiple basic classifications, an employer must keep detailed records of the actual time spent by each employee in each classification. This guidance is repeated in WAC 296-17-310171. However, WAC 296-17-31017 later states criteria that different employees must work in each business. This is contradictory and confusing to staff and customers. Auditors and account managers were unclear as to when the multiple classifications rule applied. The agency will propose repealing WAC 296-17-310171, as well as the criteria that different employees must work in each business, and consolidating all guidance for businesses and staff on this topic into WAC 296-17-31017 to streamline direction and remove inconsistencies.
3/4/2014 Public Hearing
1/21/2014 9/3/2013
This rule adoption will amend the tables of classification base premium rates, experience rating plan parameters, experience modification factor calculation limitations and retrospective rating plan size groupings for the workers' compensation insurance program for calendar year 2014. Classification base rates were amended for updated loss and payroll experience. The department proposes a 2.7 percent overall average premium rate increase. The department has added a new section describing the logger safety initiative supported by Engrossed Substitute Senate Bill 5744 passed by the 2013 Legislature and signed by the Governor. This legislation directs the department to consider incentives, such as a rate reduction, for those in the logging industry who meet specific safety criteria. The law requires the department to report to the legislature on the development and implementation of the logger safety initiative by December 21, 2013.
11/30/2013 11/1/2013 Comments Due
10/29/2013 Public Hearing
10/28/2013 Public Hearing
10/25/2013 Public Hearing
10/24/2013 Public Hearing
10/23/2013 Public Hearing
10/22/2013 Public Hearing
9/17/2013 6/18/2013
A department study identified the need for a single classification that appropriately rates product demonstrator services according to the industrys level of hazard. The proposed subclassification is a special exception available to product demonstrator services, manufacturers, and wholesalers if hiring product demonstrators with no other exposure to their business operations. At todays rates, the base rate for product demonstrators would be about 9 cents per hour higher for firms currently reporting product demonstrators in Classification 6303 (outside sales) and 28 cents per hour lower for any firm currently reporting product demonstrators in Classification 7106-01 (temporary staffing services, retail or wholesale store operations). The changes were adopted 4/1/2013 and became effective on 1/1/2014.
1/1/2014 4/1/2013 1/23/2013 Comments Due
1/22/2013 Public Hearing
11/6/2012 9/4/2012
© Washington State Dept. of Labor & Industries. Use of this site is subject to the laws of the state of Washington.
Do you plan to access the Labor and Industries website from a mobile device? (such as a phone or tablet)


text:
No place is off limits when it comes to having sex while on holidays, which includes saunas, pools, balconies and even the fire exit stairwell, a survey has found
2013-03-22 10:47:54
The survey of more than 5,000 Australians has revealed some of the unusual places people have had sexual encounters at hotels.
Guests also admitted to doing the deed in hallways and in lifts during hotel stays.
The Hotel Secrets Survey by a travel and lifestyle website found 38 percent of Australians were more adventurous between the sheets - and just about everywhere else - when they were on vacation, News.com.au reported.
It also found 36 per cent of people would consider hiring a room by the hour, while 11 per cent had chosen a hotel to hook up with an ex.
Five per cent admitted to cheating on their current partner in a hotel.
The website's general manager said holidays were all about new experiences and escaping routine so it wasn't surprising to hear Aussies were taking the opportunity to be a little more daring and adventurous when travelling.
The company conducted the survey in conjunction with the sixth birthday of an online service, in which travellers can book five-star hotels without knowing the name at reduced rates.


text:
A better way to assist pedal power?
2 posts
• Page 1 of 1
A better way to assist pedal power?Here's a interresting way to assist pedal power, and I wonder whether anyone has already done it, let alone in the time before (solid state) electronic motor controllers. The idea is to assist pedal power with a pair of reciproacting electric motors, these would also cancel out torque ripple and operate over the same (narrow) speed range as the pedals turn.
Re: A better way to assist pedal power?I think you will have to sketch that for me - just trying to work out the advantage, ie. it is easier or better in cancelling out the dead-zone?
BNA Feature: Online Australian Cycling Marketplace Report 2013
2 posts
• Page 1 of 1
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Top Bikes & Gear


text:
Whitehaus 13" Decohaus Wall Mount Pot Filler: Polished Chrome
Model: WH33-515-C-POCH
Actual Finish May Not Be Shown
- Decohaus retractable wall mount pot filler with cross handle
- Double jointed retractable swing spout
- For cold water ONLY. Not a mixer.
Product Dimensions
- Item Length, Width, Height: 13″
Current Rebates
There are currently no rebates available for this model
Internet Customer Service
Order Information |


text:
After Laurence Fishburne left his role on CSI, you knew that the showrunners would have to lure some kind of big name to replace him. He's no Morpheus, but how's Ted Danson strike you? CBS announced yesterday that good old Sam Malone is going to be focusing his laser beams and polishing off his DNA spectrum analyzer, or whatever they use on that show, for a major regular role next season as the head of the graveyard shift of the CSI crew.
Danson's coming off well-regarded turns on Bored To Death and Damages, with the latter role earning him a Golden Globe nomination and the former role apparently still continuing despite his new workload. He's a TV actor by trade, so he should fit right into the busy schedule that such a high-profile show demands, and he's a familiar face to the older demographic that CSI caters to, having been a regular on Cheers for over a decade. He'll start up with the series' season premiere on September 21st, when it shifts to Wednesdays from Thursdays.
In another TV casting news, it looks like professional dreamboat Mark Valley will be joining the cast of Harry's Law next season after the cancellation of Human Target. Valley worked with showrunner David Kelley on The Practice, so he's a known quantity, and he's certainly easy on the eyes. He's also quite attractive. I mean to say he's good-looking.
Alright, I'll stop now.


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Kobe calls 2012 U.S. Olympic team "strongest ever"
The 2012 Olympics are about seven months away, and the Americans are looking to defend their Olympic gold they won in 2008. The "Redeem Team" was powered by LeBron James, Dwyane Wade, Carmelo Anthony and of course Kobe Bryant. That team steam rolled through the Olympics, beating teams by an average of 28 points, with the Gold Medal game against Spain being the only game even close to being in doubt.
The 2012 Olympic Team will be even stronger than the 2008 team because in addition to bringing back the bulk of that team, they'll also add the best of the 2010 World Championship gold medal team. Now, thanks to Yahoo! UK/Ireland, this has led Kobe to make a very bold statement about this 2012 team (which hasn't even been completely decided).
"In terms of talent, for sure this is the strongest team we've ever had for the Olympics," he said. "This is a big Olympics for us. We have an opportunity to kind of cement ourselves again as a powerhouse of the game. We won at the last Olympics, we won the World Championships [in 2010] and now we want to win in London. Then I think that will put us back where we belong."
Thanks Kobe for giving us a jump start on the "which team is better" debate. In case you forgot, the '92 team featured Michael Jordan, Magic Johnson, Larry Bird, Charles Barkley, Scottie Pippen, David Robinson and Patrick Ewing. It's really tough to say any team could be better than that team. That was Jordan, Pippen, Robinson, Barkley and Ewing all in their primes. Toss in Karl Malone, Chris Mullin, Clyde Drexler and John Stockton in their primes and I'm not sure how you beat that team.
We think, thanks to Marc Stein, that Kobe, LeBron, Wade, Chris Paul, Dwight Howard, Chris Bosh, Carmelo Anthony and Deron Williams are locks to be on the team. You'd think Kevin Durant and Derrick Rose are near locks and I would guess some combination of Kevin Love, Blake Griffin and LaMarcus Aldridge will fill out the last two spots.
That's a great team, and the 2012 team would definitely have the edge at point guard, but that's the only position you can say that. Either way, I know I can't wait for the Olympics. Of the other teams that have qualified, Spain is the only other team nearly as complete as Team USA and despite the addition of Serge Ibaka is still going to need their best night from everyone involved to take out Team USA. The opening cermonies of the 2012 Olympics take place in London on July 27th.
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This Is Peaty - Episode 3 2012
A Mountain Biking video by steelcitymedia - 21,968 views
"It's been a tough few weeks for Steve Peat.
Injuries,crashes,punctures all add up, when racing at the highest level is so tight these days.
Even with a severely torn hamstring, Peaty Wont Back Down.
Check out Episode 3 for the full insight into the last 3 UCI World Cup Rounds + much more...
This Is Peaty."
Fuelled by Monster Energy
Supported by Five Ten, Royal Racing, Smuggling Duds, Santa Cruz Bicycles.
To keep up to date, follow us on Twitter:
A Steel City Media Production.