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Product Overview
The Syma X1 4-Channel Quad copter brings a new element to radio control helicopters, and a completely different experience of flying - balance, control, and flips are a refreshing change and new process of learning to fly. 3D flips
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Removable Battery - no battery restrictions if there are problems and more flight time with additional batteries
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1x Helicoper
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2x AB Blades


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There is a taxi rank located directly outside the terminal building.
1AB Taxis is the approved suppliers of taxis from the airport and are situated on the Taxi Rank located directly in front of the terminal in a premium location. A booking desk is available in the Arrivals area of the terminal building.
Taxis can be pre-booked:
Telephone: 01325 354444 or 01325 282828
Text a taxi: 07791 662885
Website link: www.1abtaxis.co.uk

subset: commoncrawl


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MOSCOW — MOSCOW (AP) - Russian media report that the country has written off most of North Korea's $11 billion debt.
The Russian finance ministry on Tuesday confirmed that it has signed a debt deal with North Korea, but refused to provide immediate details.
Interfax quoted deputy finance minister Sergei Storchak as saying that Russia has written off 90 percent of the Soviet-era debt.
Storchak told Interfax that the remaining $1 billion would be used as part of the "debt for aid" program in implementing energy, health care and educational projects with Pyongyang.
North Korea's state news agency KCNA said the agreement would create conditions for "boosting the relations of economic cooperation between the two countries."


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Movie DVD's & Videos for Adults - Gifts for the Trendy
Gift Buzz
The Oscars are Hollywood's biggest event, so we've rolled out the red carpet to come up with glamorous gift ideas inspired by the Academy Awards. Some of our gift ideas are based on the $55,000 swag bags the nominees will receive, while others... Read More »
This is an award-worthy list for those who reference movies on a daily basis, who love popcorn and can watch the same films over and over again and never get sick of them. Here are our top gift picks for movie lovers that will make you a smash hit! Read More »
I have always wanted one of those personal media rooms in my house. The windowless kind, that you can make really dark, so that what's on the screen appears in perfect clarity. But even if I never achieve that dream, I've just realized this:... Read More »
St Patrick's Day entertaining can be slightly more difficult to plan for than your average holiday gathering. We're going to help you and your guests experience a holiday in a way that's a step above those drugstore foil shamrock cutouts and... Read More »


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NEWARK -- Joseph A. Dixon, 33, of Newark, formerly of Centerburg, died Aug. 4, 2010.
UTICA -- A funeral service for Betty E. Grennell, 78, of Utica will be held Wednesday, Aug. 11, at 10 a.m. at Utica Church of Christ with Alan Pratt officiating. Burial will follow in Lock Cemetery.
COLUMBUS -- Margaret McCabe, 96, of Columbus passed away Sunday, Aug. 8, 2010, at Riverside Methodist Hospital.
HOWARD -- Lucile E. Parker, 89, of Howard passed away Saturday morning, Aug. 7, 2010, at Knox Community Hospital with her family by her side.
HILLSBORO -- Mary Irene (Scoles) Williams, 72, of Hillsboro passed away July 28, 2010, at Riverside Methodist Hospital in Columbus.
© Copyright 2013 Progressive Communications. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed, without the expressed permission of Progressive Communications. 740-397-5333 1-800-772-5333 Facebook YouTube Twitter Google Currents


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Green Foiled Milk Chocolate Shamrocks: 5LB Bag
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Green Foiled Milk Chocolate Shamrocks: 5LB Bag
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Doff your herringbone tweed flat cap and put down that pint glass, St. Patrick's Day is upon us like lips on the Blarney Stone and you're as candy-less as the day you were born. Better stock up with some lucky Green Foiled Milk Chocolate Shamrocks. These little clovers pair perfectly with the seasonal milkshake of the same name to bring all the boys to the yard. Don't get pinched, get candy.
There are approximately 62 pieces per pound.
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Shipping Weight ~ 6 lbs. Kosher Certified.
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Happy Birthday Jason Maroney
Bobby, Beverly, Jeff and Heather
© 2009 Anderson Independent Mail. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Education reporter Sarah Freishtat keeps you up to date on local education news.
Follow us on Twitter! Check @independentmail for headlines.
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VfB Arena - Stuttgart 06/12/2012 - 19:00CET (19:00 local time)
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Stuttgart | Molde | ||
1 | Ulreich (GK) | 1 | Bugge Pettersen (GK) |
2 | Sakai | 5 | Forren 64 |
6 | Niedermeier | 7 | Eikrem (C) |
9 | Ibišević | 9 | Moström |
14 | Rodríguez | 11 | Berget 79 |
16 | Traoré 90+2 | 14 | Linnes |
17 | Tunay Torun 30 | 20 | Angan 45+1 64 |
20 | Gentner (C) | 22 | Gatt 68 |
21 | Molinaro | 23 | Rindarøy |
30 | Hajnal 88 | 24 | Ødegård |
31 | Okazaki 70 | 29 | Diouf |
Substitutes | |||
22 | Ziegler (GK) | 12 | Söderberg (GK) |
7 | Harnik 30 | 3 | Steenslid |
8 | Kuzmanović | 6 | Hestad |
12 | Röcker 88 | 15 | Stamnestrø |
15 | Boka | 16 | Hussain 68 |
24 | Rüdiger | 18 | Simonsen 79 |
26 | Holzhauser 70 | 27 | Chima 64 |
Coaches | |||
Bruno Labbadia (GER) | Ole Gunnar Solskjær (NOR) | ||
Referee | |||
Kevin Blom (NED) |
Martin Harnik admitted VfB Stuttgart "didn't exactly cover themselves in glory" in a 1-0 home defeat by Molde FK, even if it was enough to advance to the UEFA Europa League knockout stages. A "bitter" Sven Ulreich felt that overall the Bundesliga side deserved to finish in the top two in Group E. The scorer of the only goal of the night, Davy Claude Angan, is already setting sights on gracing the UEFA Champions League next term.
Martin Harnik, Stuttgart forward
We didn't exactly cover ourselves in glory with a 1-0 defeat to Molde, but the bottom line is we got through. The ball just wouldn't go in, but you get that sort of game sometimes. We're just happy that we did enough in the end
We ought to have won the group really. That was our target, but sadly we didn't manage it. That said, we've played a lot of games with a very small squad and done the best with what we have. We're not hoping to draw anyone in particular in the next round, but personally I'd like to play against an English team.
Sven Ulreich, Stuttgart goalkeeper
It was bitter to lose 1-0 – the second time we've lost to Molde this season. Of course that's a pity and tempers our joy somewhat, but the important thing is that we got through. That was our aim. We didn't start well in the Europa League but went on to play really well twice away from home. Unfortunately we've lost another game at home, but overall I think we deserved to qualify. If you perform as we did in Bucharest and Copenhagen, you've earned your place in the next round.
We'll take whichever opponent we're given. We need to concentrate on our own game and perform well to progress. It's nice to think that we could get a big club in the next round, though.
Davy Claude Angan, Molde forward
I thought we played pretty well considering we haven't played a league match for two weeks. Our domestic campaign has already finished, so to come here and play against a team as good as Stuttgart, I thought we did well.
The coach said we should attack with pace, but it's like that every time we play. He told us that Stuttgart would want to win in front of their own fans so they'd be pushing forward, so if we got the ball we should go for it on the counterattack. The other players tried to look for me each time and get the ball up to me.
It's the first time Molde have been in the Europa League for a long time, so we've gained a lot of experience. Next year we'll enter the qualification rounds for the Champions League. Myself and all the Molde players want to play in the Champions League next year.
Magne Simonsen, Molde defender
I think it was a good performance; our team spirit was especially good. Our goalkeeper was fantastic today, he saved us. Overall we had a good match and could have scored a few goals, but so could they, so we're pretty satisfied.
We've got two very strong, fast strikers. They score goals, too, and that's what won the game for us, along with the goalkeeper. Europe is a great arena to perform in and we're looking forward to next year and hopefully qualification for the Champions League. This was a great experience for us to take forward into next year.
©UEFA.com 1998-2014. All rights reserved.


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West Virginia residents who want taxpayers to pay part or all of the cost of some job training now must take and pass drug screening tests.
The testing began July 16, as a result of complaints from employers about potential workers.
Even with the apparent necessity of the drug testing program, criticism of the plan was heard before it was implemented. No doubt complaints will increase as some applicants for job training programs are turned down because they cannot pass drug tests.
But the testing should proceed. Potential employers should be able to have confidence that if they hire graduates of state and federal job training programs, they will get people who are both capable and "clean." Many employers already require drug testing for employees, so why should people graduating from these training programs be excluded?
And the West Virginia residents who don't abuse drugs and want training shouldn't be denied it so less conscientious people can take advantage of taxpayers.
The drug testing requirement was a good idea - a necessary idea - and it should continue.


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Cuppa coffee?
13 02 2011Do you know who imports more than 900 million pounds of coffee a year?
No it's not France. No, not even the obsessed Argentines. Not even my favourite Vietnam.
It's Japan.
Yes, it's true. Apparently Japan imports more than 930 million pounds of it each year, which is more than France and less than Italy.
What does this have to do with travel? Well, sure you could ask, but that would mean you haven't been to Turkey for their sticky and thick coffee that lines the cup.
Or to Vietnam when they fill the bottom of the cup, which turns out to be enough to keep you up through the night.
How about sipping in Cairo (when they're not protesting) at one of the oldest cafes in Egypt? One where the Nobel Prize winning authors sit.
It's a drink that keeps the world ticking and one that you will never be far from where ever you are. Sure there is tea, but coffee is my poison.
Of course, I am sad to say that my favourite is Starbucks. Yes, I have been around the world. I have tried coffee in lots of places, but my favourite coffee stop is Starbucks.
Plenty of caffeine in their regular coffee and the quality is guaranteed to some degree everywhere you go. Of course that can't guarantee the Inca Bucks in Peru!
Categories : Photo Essay, travel, Uncategorized


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g a r y w o n g . o r g is currently undergoing renovation as it moves on to its next phase.
- For my personal blog, please visit wonggawei.com.
- To see some photos, please visit thewongway.org.
- The asides will go into a new site - place and time TBD.
Sorry for the inconvenience.


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Sandwich Bread/Dinner Rolls
Categories: Breads, Recipes
Tags: , Allergy Friendly, Best Gluten Free Breads, Dairy Free, Dinner Rolls, GFCF, Sandwich Bread, Vegan, Vegetarian, Yeast Bread
Everyone wants a sandwich sometimes. Everyone. When the craving hits you for a sandwich, run … don't walk to make a delicious homemade loaf, regardless of your food restrictions. This awesome recipe produces a loaf you can slice as thick or as thin as you like, and it may be made nearly allergy-free! Gluten-free, dairy-free, soy-free, nut-free … and higher fiber than a regular white bread, this loaf will stay moist for days (if it lasts in your house that long!). Pass the recipe along to anyone you know with other food restrictions and share the wealth!
I wrote the recipe for bread maker or traditional oven method. If you do not have a bread maker, it is best to use a stand mixer or a large food processor with a dough blade, as this dough is very thick.
While I love using yogurt as an ingredient in my breads – it keeps the crumb nice and moist for days – it is a variable in baking. Whether using low fat, fat free, soy, rice, coconut … they all have different moisture levels and viscosities. Thus, the directions indicate the approximate amount of yogurt recommended for this recipe; depending on the yogurt used, a small amount of extra yogurt may be needed to thin this thick dough to the consistency needed to spread out in a pan to form a nice loaf.
One last thing: if you're really more of a mix person, use my easy Gluten-Free Bread Mix, and you won't be disappointed! It turns out a beautiful artisan loaf with a nice crunchy crust, from the oven or bread machine!
Sandwich Bread or Dinner Rolls
- 2 Tbs. agave nectar or honey
- 1 1/4 cup plain yogurt (dairy or non-dairy) OR milk (not skim) OR Gluten-Free Beer or hard cider
- 1 tsp. apple cider vinegar
- 1/4 cup extra virgin olive oil
- 2 large eggs (or 2 Tbs. flax seed meal steeped for 10 minutes in 6 Tbs. hot water)
- 2 3/4 cups Jules Gluten Free™ All-Purpose Flour
- 1/4 cup flax seed meal
- 1/2 cup millet flour (or buckwheat, brown rice, sorghum, GF Oat or almond flour)
- 1/4 cup dry milk powder (dairy or non-dairy, like Vance's DairiFree™ Milk Powder OR almond meal)
- 1/2 tsp. baking soda
- 2 tsp. baking powder, gluten-free
- 1 tsp. sea salt
- 1 tsp. granulated cane sugar
- 1 Tbs. rapid rise or bread machine yeast, gluten-free
- 1 Tbs. flaxseeds or sesame seeds
- 1 Tbs. coarse sea salt
Oven Directions:
Whisk these dry ingredients together in a large bowl: flours, milk powder, baking soda, baking powder and salt.
In the large mixing bowl of a stand mixer, stir together the remaining wet ingredients (honey, yogurt, apple cider vinegar, oil and egg or flax seed and water mixture). Gradually add the dry ingredients in with the wet by pouring slowly into the wet bowl while mixing with the paddle attachment. Once incorporated, add the yeast granules and sugar, and beat well – 1-2 more minutes.
The dough will be very thick (much more like regular wheat flour bread dough than you may be used to with gluten free); however, if the dough seems too thick to spread into a loaf pan, gradually mix in more yogurt, one tablespoon at a time, until the dough is still thick, but able to be smoothed with a spatula.
Scoop the dough into an oiled bread pan (use a dark metal pan if you like a darker crust on your bread; lighter, shiny metal or glass if you like a light crust).
Smooth the top, sprinkle with any toppings, then cover with a damp towel or a sheet of wax paper sprayed with cooking oil. Sit the covered dough for at least 30 minutes in a warm place like an oven warming drawer or an oven preheated to 200º F then turned off.
Remove the cover from the raised dough and transfer to a preheated convection oven set to 275º F or a preheated static oven set to 300º F. Cook for approximately 60 minutes, or until the crust is browning nicely and a cake tester or skewer inserted into the center of the loaf comes out clean (internal temperature should reach 205-210º F). Remove to a cooling rack. When cooled for 15 minutes, gently remove from the loaf pan to finish cooling before slicing.
Dinner Roll Directions:
Prepare muffin tins or popover trays by oiling. Scoop equal amounts into each tray and smooth the tops. Sprinkle desired toppings. Cover and rise as directed above. Bake at 350º F convection or 375º F static for 15 minutes, or until set.
Bread Machine Directions:
Whisk together the yolks and whites before adding to the bread machine with the other liquids; alternatively, allow the flax seed meal to steep in water for 10-15 minutes before adding. Bring all liquids to room temperature before adding to the machine, if possible. Whisk together dry ingredients and add on top of liquids in the pan. Make a well in the center and add the yeast. Select either the gluten-free bread setting on your machine, or the setting with only one rise cycle and no punch-down (2 lb loaf setting).
Once the ingredients have mixed, the dough will be very thick (much more like regular wheat flour bread dough than you may be used to with gluten-free); however, if the dough seems too thick as it is mixing in this recipe, gradually add more yogurt, one tablespoon at a time while the bread machine is mixing, until the dough is still very thick, but able to be smoothed with a spatula. Be sure to check the bread with a spatula throughout the mixing process to ensure that all the dry ingredients have been incorporated.
When the machine is done mixing, smooth the top with a rubber spatula and sprinkle any desired toppings on top of the loaf. Close lid to bake.
Test the temperature of the interior of the loaf before removing from the pan – it should have reached approximately 205-210º F. If it hasn't yet reached that temperature, either add time to your bread machine as another bake cycle, or simply put the pan into a regular oven at 350º F (static), testing the temperature again at five minute intervals.
61 Comments
We'd love to hear yours!
Larry Bennion said: on October 17, 2010
Jules, I purchased your 2010 Thansgiving recipe book, found a bread / rolls recipe I think on page 10 and 11, I followed this recipe to a "T" and it looked fantastic in the oven, I didn't jar it,let it cool off and when it was taken out of the oven when done, it fell like a rock, the inside is nice, not full of holes,and taste is excellent, especially right out of the oven loaded with butter!! I have done this in the past however the yeast was put in liquid by itseld and added sugar to this then warmed to 110 degrees, this seemed to work better, not great but better. I guess I am ooking for tips as to what I may have done wrong. Oh, and to answer your first question, my yeast is not old, first thing I looked at. Hopefully you can help. Larry
Jules said: on October 19, 2010
Hi Larry – the process you're describing is called "proofing" the yeast before adding to the recipe. I've done this in some recipes, but it shouldn't really make a difference in gluten-free breads. All that being said, if you have success with any method, stick with it! As for the bread/rolls recipe – which did you make – bread or rolls? If you made a loaf, try it as rolls and see how it does. Also, this recipe has many variables, such as whether you choose ginger ale or gluten-free beer; flaxseed meal or sorghum flour (as examples), so try another option listed next time to see if it works better for you. How long did you let it/them rise and was it a nice, warm location? I've found that covering my rising breads with a thin, damp towel really helps. You should feel free to let the bread rise longer, as well; adding rise time can give the dough the benefit of getting "comfortable in its skin," so to speak, as it more gradually building the cell structure. Another thing to try may be to lower your oven temperature and bake a bit longer – every oven is different and that can sometimes help. Lastly, you may want to try my bread mix since all the dry ingredient variables are taken out and all the measuring is done for you — it can make things a little easier! Whatever you do, don't give up (it doesn't sound like you're the kind who would!) – I promise you that fresh-baked, delicious gluten-free bread is possible!
Lucie said: on October 21, 2010
Could someone tell me what other flour than Millet could I add to this bread recipe?
Jules said: on October 21, 2010
Hi there,
Don't feel like you must use millet flour – get creative according to your tastes and what you have on hand. You can always just use an equal portion of my flour instead, but I also like using buckwheat, sorghum, flaxseed meal, or brown rice flour to add more fiber and flavor.-
Mary said: on August 17, 2011
Instead of millet flour I can use an additional 1/2 cup of your flour?
Jules said: on August 17, 2011
Hi Mary, yes, absolutely you can simply use my flour instead. I like adding Millet or Buckwheat or even Flaxseed Meal for added nutrition without compromising on the taste, and I find that amount of a whole grain flour tends to yield a bit more structure. Hope that helps!
Kei said: on November 7, 2010
I don't have dry milk. Can I use whole milk as a substitute? What will happen if I do? Thanks for your reply.
Jules said: on November 7, 2010
In recipes calling for dry milk, you cannot substitute with liquid milk or it will throw off the liquid:dry ratio in the recipe. In this particular recipe, you can actually leave out that ingredient and it will still be a nice loaf, just less dense. It's actually softer and really delicious without the dry milk powder, but it can be harder to slice thinly. Great question!
Kei said: on November 10, 2010
Great! Thanks for replying so fast! I've got a loaf rising right now. I can't wait to try it! I'll post the results when it's done.
Sheri said: on January 26, 2011
When covering the dough to rise I have found the cover pulls off the top of the dough when I remove it. How can I prevent that from happening?
Jules said: on January 26, 2011
When that happens to me, I spray wax paper with cooking oil and lay that on top, then a warm damp towel over that. It usually works well to solve that problem!
Stacy M said: on February 28, 2011
I am new to using yeast. By mistake I bought Active Dry perfect rise yeast, will this work? Or how are they different then rapid rise? Thanks!
Jules said: on February 28, 2011
Hi Stacy, active dry will work, but will take longer to rise. Since we don't punch down and give a second rise to gluten-free breads, we can have our bread ready much faster! That's where the rapid rise yeast comes in. It also works best for bread machines. Follow the baking directions, but understand you will need to add time to allow the bread to rise longer.
Pam Greenfield said: on June 2, 2011
Wanted to post that a technique that GF Goddess recommends worked well for me – when using a bread machine – immediately remove bread from pan and place in a 350 degree oven for about 10 minutes and it helps an overly moist loaf to dry out and not sink so badly. But do it before the loaf sits for any amount of time in machine after it's done!
Holly said: on December 16, 2011
Jules, WOW love this recipe! I'm Yeast Free as well so it's taken me a long time to work up the courage to try bread from scratch. The only thing I had to substitute was almond flour for the flax seed meal. As well as use equal parts baking powder & lemon juice to substitute for the yeast. It turned out wonderful. I made one loaf to see how it would go but plan on making several more loaves to store in the freezer. Thanks!
Jules said: on January 2, 2012
Holly – that's fantastic! So glad you were able to modify this recipe to make it yeast-free as well! I have another yeast-free bread recipe that you should try sometime – it's in my Free for All Cooking book as well as my bread-baking ebook . I'm really interested in how you subbed for yeast in this recipe though. You said you used equal parts baking powder and lemon juice — how much did you use for this recipe? I've got to give that a try!!! Thanks for the information!
Jenn said: on January 28, 2012
hi – i just bought your book, free for all cooking, and i wanted to try the sandwich bread recipe. i'm new to the gf and allergy-free cooking and i am wondering if there is a substitute for the yogurt in this recipe? or can i leave it out?
Jules said: on January 29, 2012
Hi Jenn, you can't just leave out the yogurt, but if you'd rather, you can use Kefir or even sour cream. Even if you can't use dairy, those are both available dairy-free, too. Enjoy!
Kim said: on February 13, 2012
Hi Jules,
I tried the bread recipe from your Thanksgiving recipe book (different from the one posted here) using my bread machine on the deluxe rapid setting (so it would only have 1 rise and no punch-down) for a 1.5 lb loaf. It looked great when I pulled it out, but then as it was cooling, I realized that dough was oozing from a crack in the top crust and after cutting into the top part, it was obvious that it wasn't done. I tried baking it longer in my oven to see if I could save it, but it fell as soon as I took it out and was really gooey/chewy/dense. I did notice that I had accidentally grabbed the Active Dry Yeast instead of a rapid rise. I also opted for the dry milk powder Any suggestions? Should I choose a larger loaf size for a longer bake time? rapid yeast? Should I try using this recipe instead?? I'd really like to find a way to do it well with my breadmaker to save on time. Thanks!-
Jules said: on February 17, 2012
Hi Kim- a couple ideas for you. The yeast, unfortunately, does make a difference, so try the instant next time. The milk powder should be fine. The loaf size is too small though – do you have a 2 or 2.5lb loaf setting on your machine? It would be great next time you're at the grocery store to grab an instant read thermometer as well – you can use that to check whether your bread is done in the machine, so you can just add time there if you need. The loaf should be 205-210 F before it's done. Let me know how it goes next time, or feel free to use this recipe or my bread mix instead. Also, email us at email@example.com any time for us to walk through recipes with you to help you get them just right!
Kim said: on February 17, 2012
Great, thanks!
Gayle said: on May 8, 2012
Jules, thanks for the recipe. I am always concerned about using yeast at all in baking. I have deleted it from my diet since it aggravates and causes candida and ultimately results in lowering my healing – celiac stomach – from absorbing the necessary nutrients I need to heal. With that said – what can I substitute for the yeast? I take Candex and probiotics and feel like I will be wasting them by adding yeast while taking those supplements to rid my body of yeast. Thanks.
Jules said: on May 8, 2012
Gayle, I'd recommend my yeast-free GF sandwich bread recipe from Free for All Cooking. It's a wonderful recipe and should suit your dietary needs.
Rebecca said: on September 1, 2012
Hi Jules, just wondering what size loaf pan to use with this in a conventional oven. Can't wait to try it! Thanks
Jules said: on September 2, 2012
Hi Rebecca – just use a standard loaf pan (8.5 x 4.5 or something similar) if you're baking as a loaf instead of rolls. Enjoy!
Christina said: on September 15, 2012
Is it ok to substitute regular salt for the sea salt? I had some and it has disappeared…
Jules said: on September 16, 2012
Hi Christina, yes, that sub is fine!
Christina said: on September 16, 2012
Do you have any nutritional information on this recipe? My daughter has celiacs and is a diabetic..so I need to have the carbohydrates in a slice for her diet. Does this recipe compare to regular bread?
J Christie said: on November 14, 2012
Tried this recipe yesterday, turned out great.
It fell just a tiny bit but the crust was perfect.
Only problem next day it was dry even though I put it in an air tight container.
Jules said: on November 14, 2012
Hi J Christie – perhaps you should cut back on the bake time a bit next time? It shouldn't be dry the next day, so that would be my best guess. If that ever happens with any recipe, you can always wrap the bread in a paper towel and microwave for a tiny bit before eating. Let me know how it goes next time you make it! I'm glad it was great and you loved the crust, though. That's my favorite part, too!
teri pastorino said: on December 31, 2012
i just made this bread and i like the consistency. was a little rubbery at first but after cooling completely and sitting overnight it was pretty good. it is extremely yeasty though! is 1Tbs really the qty of yeast? i am new to this gluten free baking as having just been diagnosed.
Jules said: on December 31, 2012
Hi Teri, glad you let it cool a bit and were able to enjoy it! If you would rather use one packet of yeast, that is 2 1/4 tsp of yeast, and that will work. If it is still too yeasty for your liking, you can proof the yeast first and then add it to the dough during blending. Congratulations on diving into GF bread making so soon after your diagnosis. That means that you are well on your way to tasty and delicious gluten-free foods already!!!
Shanna Duggan said: on March 20, 2013
Jules, I recently tried my hand at bread baking with your pre-packaged bread mix so I could eliminate eggs from my DS diet (he's allergic). It turned out delicious, however, I am allergic to flax seed and my DS said it "tasted funny". Can the recipe above be successful without the flax?
Jules said: on March 20, 2013
Hi Shanna, you could substitute another flour for flax here in the same proportion, so 1/4 cup of almond meal, buckwheat, millet, sorghum, brown rice flour – any should work. As for the egg replacer though, you would also need to find one without flax. You could use chia seed in the same way, if you can tolerate that. Regarding taste, I'm glad it was delicious! Not sure about your DS's comment – perhaps because it's more of a whole grain bread than he's used to?
Carol said: on March 21, 2013
Thanks for the recipes. In the past few months my son discovered he is gluten sensitive. He is lucky that he can get away with some gluten but when he has too much, he knows about it. I have made some GF biscuits and scones that turned out good. Have a new Cuisinart bread machine with a GF setting. Want to try this recipe. I have everything except cider vinegar. Anything I can use instead? Thanks again for your website.
Jules said: on March 21, 2013
Hi Carol – so glad you are enjoying the biscuits and scones! As for apple cider vinegar, if you do not have that ingredient, substitute with lemon juice instead. Hope that helps!
Evelyn Gutierrez said: on May 7, 2013
Hello, I am pretty new to the gluten free idea, SPECIALLY dealing with breads.
I will try to bake this bread for my bread eater 2 years old. She also has allergies to yorgut. What can substitute for that?
Jules said: on May 7, 2013
Hi Evelyn – what kind of yogurt is your little bread eater allergic to?
Evelyn Gutierrez said: on May 10, 2013
Hello Jules. Any soy or almont milk. I pretty sure is the fermantation. My husband started making fresh "yogurt". He simply blends any fruit with a little of almont or soy milk and raw honey. Can I use that in place of the yogurt?
Jules Shepard said: on August 27, 2013
Absolutely! That should work just fine!
Sara said: on July 22, 2013
Hello! I made your bread mix and I have been able to make grilled cheese and french toast again! I want to just make it from scratch I have all the ingredients but flax seed meal, do I have to use this or is it really for added nutrition?
Jules Shepard said: on July 23, 2013
Hi Sara, that's wonderful to hear! No one should have to go without grilled cheese and French Toast! If you don't have flaxseed meal, just use equal parts of my flour instead. It's mostly for nutrition and flavor, but it also provides some structure. My bread mix isn't exactly this recipe, so there will be differences, but hopefully you'll love the recipe, too!
Jennifer said: on August 23, 2013
How much should the dough rise? After an hour in a warm spot it only rose about an inch.
Jules Shepard said: on August 27, 2013
Hi Jennifer, this is a heavy dough (because of the yogurt) so it doesn't rise a lot before baking. Hopefully it was higher after the bake cycle, though!
Carol Cornwell said: on October 12, 2013
I've baked a lot in my day — with wheat flour — and have usually been happy with the results, but I can't get this bread recipe right. I've tried it twice now. I measured carefully, combined ingredients carefully, and baked in a static oven as directed. The resulting bread turns out quite dense, brown on the outside, but not done in the middle even after over-baking. Definitely disappointing. I'm stymied.
Jules Shepard said: on October 13, 2013
Hi Carol, I'm sorry to hear you're having trouble with this recipe. Are you using my Jules Flour? What kind of yogurt are you using? Are you using an egg sub? What is the additional flour you are using? All of these can make differences. Why don't you send an email to us at firstname.lastname@example.com and we can walk through what you used and some other methods that might help you get this recipe right. It's easier to answer specific questions via email. Thanks!
Tiffany said: on October 24, 2013
Gluten Free Bread Rising Method
My method for rising bread which by the way is the best method I've come up with until this very day. Anything to make the whole process simpler is what I do. Works great in a cold room as well.
1. Get a heating pad and set on medium. I place the heating pad on a "dish drying mat.' I do this because of my stone countertops which do not handle any heat on them whatsoever so this way everything is "protected."
2. After I've mixed up the bread and placed dough in pan, I place said pan on the heating pad.
3. Now here's the fun part plus it's very easy to see just how much the bread has risen. Purchase one of those plastic clear shoe storage boxes (got mine from WalMart). Toss the lid or set aside as you'll not need it. Place the OVERTURNED shoe box over the pan of dough. Set your timer for recommended rising time …. and you're set to go. No spraying waxed paper or plastic wrap or anything. The plastic shoe box NEVER even gets close to touching the top of the rising bread. How clever is that!
4. I also set my oven temperature (static, so that I won't get any crazy oven rising loaves) once I've got my GF dough rising so everything is "ready to go" when the bread is at the rise I want.
Works for me maybe it'll work for you as well.
Jules Shepard said: on October 25, 2013
I love it, Tiffany! Thanks so much for sharing your rising method – especially the part about how you can watch to see how high it's risen! I can't wait to try it with a heating pad!!
Magi Guilfoyle said: on January 20, 2014
I was recently diagnosed with CD. I received a bread machine for Christmas. Jules, can I bake all of your bread recipes in my bread machine?
Jules Shepard said: on January 20, 2014
Hi Magi – what a great Christmas gift! Santa must have thought you had been very good! To answer your question, yes, you can make any of my yeast bread recipes in the bread machine. Just put all the liquid ingredients on the bottom of the bread machine pan and the dry ingredients on top and the yeast in the middle. You may have to help the machine by going around the pan with a rubber spatula to make sure all the ingredients are mixed well, but that's all dependent on how well your bread machine mixes. Have fun baking with your new toy!
John Edwards said: on January 22, 2014
would I set my breadmaker for 2 or 3 LB's for this recipe?
Jules Shepard said: on January 22, 2014
Hi John, 2 lb loaf. (Great question!)
Stephanie said: on February 21, 2014
Hi, I have a step son who was recently diagnosed with CD. I haven't had the pleasure of cooking for him yet since he lives with his mom out of state, but I am preparing for this summer when he is here. He is 14 and so far not a fan of any home made gluten free bread he has tried, so of course I take that as a challenge to make a GF bread that he will like, and he can use for sandwiches without it falling apart. Is this the recipe you would recommend for that? I have a cuisinart convection bread maker CBK-200, and it has a gluten free setting, So I have high hopes that this will work for sandwiches- because seriously what teenage boy should live without sandwiches? Also- do you have a recipe that you would recommend for hamburger buns?
Jules Shepard said: on February 23, 2014
Hi Stephanie, what a wonderful challenge you've set for yourself, and completely achievable, I might add. Your GF breadmaker will work just fine with this recipe or others of mine on my blog. One of my favorite breads (especially for kids and teenagers who aren't as into "whole grain" textures) is my beer bread recipe. It works with GF beers or other carbonated liquids like Perrier, club soda, 7-up or carbonated ciders. It produces a light loaf that is soft and not grainy if you use my flour. It also works great for hamburger buns! Click on the embedded links to find the recipes or you can search on my blog. Let me know how it goes!!
Cynthia Powers said: on March 1, 2014
Is this recipe for a 1 lbs or 2 lbs loaf?
Cynthia Powers said: on March 1, 2014
never mind found the answer 2 lb
Jules Shepard said: on March 1, 2014
Glad you found what you needed, Cynthia!
18. Oct, 2011
[...] #split {margin-left: 0px;margin-right: 0px;}#single {margin-left: 0px;margin-right: 0px;}#splitalign {margin-left: auto; margin-right: auto;}#singlealign {margin-left: auto; margin-right: auto;}#splittitlebox {text-align: center;}#singletitlebox {text-align: center;}.linkboxtext {font-size: 6px;line-height: 0.6em;}.linkboxcontainer {padding: 0px 0px 0px 0px;background-color:#ffffff;border-color:#ffffff;border-width:0px; border-style:solid;}.linkboxdisplay {padding: 0px 0px 0px 0px;}.linkboxdisplay td {text-align: center;}.linkboxdisplay a:link {text-decoration: none;}.linkboxdisplay a:hover {text-decoration: none;} function opensingledropdown() { document.getElementById('singletablelinks').style.display = ''; document.getElementById('singlemouse').style.display = 'none'; } function closesingledropdown() { document.getElementById('singletablelinks').style.display = 'none'; document.getElementById('singlemouse').style.display = ''; } Cooking For Two: Gluten-free bread for your butterQ&A: when making bread do u need to add gluten to the mix?Cookbook Giveaway! Simply Sugar and Gluten-Free!Bread, glorious breadGluten Free Bread Mix – Q&A: Anyone got any good gluten free bread recapies?Easy Wheat-Free Bread RecipesWhite Sandwich Bread/Dinner Rolls [...]
28. Nov, 2011
[...] Adapted from Jules Gluten Free Bread Roll recipe. GA_googleAddAttr("AdOpt", "1"); GA_googleAddAttr("Origin", "other"); GA_googleAddAttr("LangId", [...]
08. Dec, 2011
[...] loaf gluten-free sandwich bread or French bread (3-5 days old/stale or thawed from frozen works [...]
24. Oct, 2013
[…] * Adapted from Jules Gluten Free Bread Roll recipe. […]
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Jeff Barth is the Marketing Manager for Catalyst Europe. In this role, he leads the European marketing strategy for member engagement and works with the communications and branding teams to leverage Catalyst's presence across platforms within Europe. Mr. Barth manages a number of priority members and provides tailored strategy sessions on approaches to diversity and inclusion. In addition, he currently serves on both the Catalyst Canada Honours evaluation committee and the Diversity and Inclusion Advisory Council.
Prior to assuming his role as European Marketing Manager, Mr. Barth was an Associate in Catalyst's Public Affairs department, where he worked on the branding, marketing, and creation of press releases. He also helped to produce key messaging for company products and events, evaluated and created new products utilizing social media, and assessed new markets for receptivity to Catalyst research and viability of corporate presence.
Before joining Catalyst, Mr. Barth managed political campaigns for candidates running for federal and local office in Utah. He also taught English in Tianjin, China. Mr. Barth received a joint Bachelor's degree in political science and sociology from Utah Valley University and is currently studying Mandarin.


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A picture archiving and communication system (PACS) is clearly a requirement for any radiology department or healthcare organization that is going to survive into the 21st century. The impact of managed care and the requirement for regionalized healthcare are among the drivers of PACS.
When using the term PACS, the following components are implied: radiology information systems (RIS), teleradiology, information networks, archiving schemes, diagnostic reading centers, compression techniques, and so forth. It appears that PACS is becoming a catch-all for any hardware and software devices/tools that attach to the diagnostic imaging network (excluding the imaging acquisition modalities of CT, MRI, etc.). Therefore, computer-aided-diagnostics techniques may become a part of the PACS infrastructure.
In a presentation at HealthTech '97, Dr. Ed Staab, of the University of Florida in Gainesville, cited cost, productivity, and diagnostic accuracy as key areas for focus in the future. Cost and diagnostic accuracy are considered below. PACS is the answer to achieving higher productivity levels within a department, institution, or regionalized grouping of institutions. PACS technology enables reengineering of process to take place at the highest levels of productivity gain.
To date, unfortunately, most of the applications associated with PACS have not resulted in significant gains in productivity. The reason for this is that new technology for PACS was purchased without adequate training associated with reengineering of process. The result has been a low-value condition due to large expenditures without adequate payback.
This situation is changing. Well-documented examples of significant productivity gains and adequate payback obtained from PACS are now available. In some cases, the major gains are found within the hospital and not only in the radiology department.
Several interesting trends associated with PACS were demonstrated at the 1996 RSNA. The integration of PACS components, such as workstations, teleradiology, radiology information systems, and even telemedicine, was demonstrated. The general trend is
to give the customer confidence that a "total system" concept is feasible and that the challenges associated with interfacing equipment are under control. The industry still has not forgotten the interface nightmare associated with digital subtraction angiography equipment.
In addition, several manufacturers demonstrated products that utilize the Internet and worldwide web technology to gain access to imaging databases and information. This area is expected to grow rapidly. The opportunities for sharing clinical study databases and for calling upon algorithms for computer-aided diagnostics are significant.
During the next several years, it is expected that PACS will be one of the fastest growing segments of the diagnostic imaging industry.
Patient-driven purchasing criteria
This is a gradual shift that will probably take another three to five years to reach fruition. However, the trend in this direction has clearly begun.
Over the last 15 to 20 years, the criteria for purchasing diagnostic imaging equipment usually have been based on the following factors.
Factors 3 and 4 together represent the profitability of the customer. For example, a CT site where the throughput is 25 patients per day and the life cost is 4 patients per day has a profitability (given the availability of patients) that is based on 21 patients per day.
The factors noted above are sometimes referred to as the old high 5 or specification-based factors. When looking at comparisons between different products, many terms are used. Most often, however, they can be summarized in terms of the factors noted above.
During the last few years, with the advent of managed care, it became apparent that a key ingredient is lacking in the old high 5. That ingredient is the patient. Therefore, it is important to consider a set of factors (sometimes referred to as the new high 5 or outcomes-based factors) that are consistent with the thinking and directions of today and the future. The following set of factors are believed to be appropriate for this purpose.
1. Technical performance-This consists of diagnostic accuracy, sensitivity, and specificity.
2. Diagnostic impact-Does the procedure in question affect the diagnosis? That is, does the procedure provide additional useful information that will alter the conclusion regarding the diagnosis?
3. Therapeutic impact-Does the procedure in question affect the therapy? That is, does the procedure provide additional useful information that will alter the course of the proposed treatment?
4. Patient outcomes-Does the procedure in question affect the morbidity and mortality of the patient? In radiology, there is concern about the feasibility of performing a measurement of outcomes for the radiology portion of a study.
5. Cost-effectiveness-Is the procedure cost-effective relative to existing procedures that are being utilized with existing equipment? Measurement of cost-effectiveness would combine factors 3,4, and 5 under patient-driven purchasing criteria.
It is apparent that the effect of managed care has widely modified the thought process associated with the purchase of equipment. The new high 5 have a clear direction in terms of the patient, which was almost totally lacking in the old high 5.
Decisions being made today regarding the purchase of equipment either rely on the old high 5 or contain a blend of the specification-based and outcomes-based factors. The difficulty in the conversion coming to fruition is a combination of the general difficulty in changing as well as the difficulty in reaching agreement on the definitions of outcomes.
Manufacturer as consultant
This is a natural progression of the "total service" element of the old high 5 discussed above.
In the days of x-ray, service meant reliability of the equipment. As CT and ultrasound came on the scene, applications became an important part of servicing the customer. MRI brought with it the need for the manufacturer to assist the customer with marketing. This was especially true for the private outpatient market. As PACS entered the scene, the need for long-range planning became evident, and the manufacturer often provided this service using internal or consulting personnel.
The buzzword today is "asset management." Within asset management, some manufacturers include equipment planning, productivity enhancement through reengineering of process, multivendor service, and so forth. The right approach for tomorrow may be found by considering the changing role of consulting.
As a business, consulting is changing from providing customers with the right answers to "enabling the customer" to generate the right questions. With the right questions in hand, the customer (as part of a team) will be able to establish the scenarios leading to the right answers. The consultant would be available to serve as facilitator. Strategic thinking is a technique that uses "tools" or "frameworks" to facilitate the process of enabling. The concept of "strategic thinking in radiology" was introduced last year in an article in Applied Radiology.1 Many of the tools noted below can be found in that article.
Strategic thinking is a very meaningful approach to medicine, considering the situation in which clinicians and, in particular, radiologists, find themselves. The advent of managed care has created perhaps the most difficult situation with which radiology has ever been confronted. Practices are being combined, reduced in size, and, in some cases, eliminated. In this environment, answers (often different from different sources) are very confusing at best. The radiology team must be able to understand what is going on around them and play an active role in determining the questions and answers associated with their future.
To enable the customer, it is important to understand the management process that a radiology practice would be considering regarding the purchase of equipment. The following steps have been found to be representative in many situations (the appropriate strategic thinking tool will be included in each step of the process).
1. The practice needs to understand how it wants to be positioned in a three-to-five-year time frame. Associated with that position, the decision makers must determine the strategic steps required to attain the desired position.The vision statement tool is appropriate. An example of a vision statement is found in the accompanying editorial.
2. Consistent with step 1, the equipment requirements (acquisition devices, PACS, networks, etc.) are selected as a function of time over the period. The growth development tool is appropriate.
3. As an equipment milestone is approaching, an evaluation of the necessity to purchase is determined based on the current situation. The real-win-worth tool is appropriate.
4. A review of the requirements within the "regionalized healthcare environment" and the fit of the equipment in question are then carried out. The core tool is appropriate.
5. Once a positive decision is reached regarding purchase of a specific type of equipment, an analysis is required to determine the best source of supply. The high 5 tool is appropriate (see the discussion above).
6. Cost needs to be analyzed from a system perspective, taking into account initial equipment cost, service, up-grades, etc. The total tool is appropriate.
7. To ensure success of utilization of the equipment in question, the highest levels of productivity (reengineering of process) need to be achieved. The two-by-two tool is appropriate.
8. Management of the entire process requires a team effort with clearly defined responsibilities. The sheet-of-music tool is appropriate.
Manufacturers that provide the type of consulting described above will be able to differentiate themselves from their competition and provide the best service value to their customers.
Technical innovation
Innovations in technology continue in a highly selective manner.
PACS is clearly one of the main areas for investment in research and development. Over 30 companies are participating in some aspect of extending the forefront of PACS technology (see discussion above). Other areas that are receiving significant investment resources in the diagnostic imaging field include the following.
Ultrasound-More than 20 companies are providing investment in this modality. Areas of focus include high-performance imaging (high frame rates, large FOV, higher resolution), 3D imaging, breast imaging, and PACS/network-related products.
Digital mammography-This area remains one of the last segments of medical imaging to turn to digital technology. Technical developments fall into the categories of area detectors and line-scan detectors. Materials include silicon for direct detection and CCDs using scintillators. All combinations were shown at the 1996 RSNA.
Digital detection (excluding mammography)-This is focused on repla-cing image intensifiers, computed radiography systems, and detectors for nuclear medicine and PET. Silicon and selenium are among the technologies being considered.
X-ray-In order to increase value, manufacturers are creating systems with greatly increased flexibility as "multipurpose rooms." Radiography, RF, vascular, and interventional procedures can now be performed with a single system configuration.
MRI-Although more than 15 participants continue in MRI, the number of new developments has slowed. Magnetic resonance-guided therapy, specialty scanners, and low-field open systems appear to comprise most of the new development.
CT-As with MRI, CT has seen a reduction in new developments. Helical scanning continues to be one area of development that is receiving attention. Additional areas for future development are noted in the editorial.
Alliances, acquisitions, and mergers
Such agreements are expected to continue along the path that has been evident during the last few years.
A major factor that is accelerating this trend is the lack of profitability of small companies. A study performed by WDI Capital Markets shows that profitability was elusive for the majority of healthcare companies with revenues under $25 million.
Large-scale companies have set the tone for growth through the implementation of an aggressive acquisition strategy. They have gained strength from increased market penetration and the classic economies that come with consolidation. Conversely, smaller companies are finding it more difficult to compete against larger firms, as buyers increasingly negotiate exclusive agreements for "bundled" products and services at discounted prices.
A representative example of the acquisition strategy can be found in Trex Medical. Through a series of acquisitions, Trex has become one of the fastest growing companies in the field of diagnostic imaging. Acquired companies include Lorad, Bennett X-Ray, Continental X-Ray, and XRE. Trex, a division of Thermo Electron, is following in the path of its parent. The corporate philosophy has been to grow through acquisition.
Another example of interest can be found in Sterling Diagnostic Imaging. Sterling acquired the Diagnostic
Imaging Division of DuPont and the Helios Division of Polaroid. Sterling is betting on the combination of digital imaging and high-performance film technologies.
Positron's acquision of GE's PET program (acquisition in process) is an example of a new trend. In this case, the small, niche company is becoming a dominant player in the niche, while the large company removes itself from a market that is too small to be worth the effort. Positron will supply the product to GE's specifications so that GE can continue to offer its customers a complete line of products. AR
1. Schilling RB: Strategic thinking for radiologists. Appl Radiol 25(8):11-14, 1996.


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Another test for David Moyes, and another spectacular failure. Just how...
Man City survived a difficult afternoon with ten men to close the gap...
ur sentiments exactly. But it seems some do care. We have lots of mails about Tim...
avid Moyes is 'absolutely awesome' but very slow, Neil Custis and Robbie Savage...
Sky Bet have expanded the market for teams to finish in the top four. Could there be a surprise qualifier for next season's Champions League?
Check out the latest outright odds on next summer's World Cup in Brazil, where the hosts are the favourites.
Predict six correct scores for your chance of winning the £250k jackpot. Terms and Conditions apply.
Who will be the next managerial casualty in the Premier League? Norwich boss Chris Hughton is among Sky Bet's front-runners.
Haven't chosen your team yet? Don't worry - sign up anytime throughout the season and still be in with a chance to win weekly and monthly prizes!
Tuesday, 18 March 2014 | |||
19:45 | |||
Charlton | v | Bournemth | |
Sheff Wed | v | QPR | |
Wigan | v | Yeovil | |
Saturday, 22 March 2014 | |||
12:15 | |||
Derby | v | N Forest | |
15:00 | |||
Barnsley | v | Bournemth | |
Birmingham | v | Reading | |
Blackburn | v | Leicester | |
Blackpool | v | Huddersfld | |
Brighton | v | Ipswich | |
Charlton | v | Burnley | |
Doncaster | v | Sheff Wed | |
Leeds | v | Millwall |
Liverpool boss Brendan Rodgers played down his side's title hopes despite the impressive 3-0 win over Manchester United.
Liverpool captain Steven Gerrard believes the 3-0 win at Manchester United demonstrated their title-winning credentials.
David Moyes acknowledged Liverpool were the better team after Manchester United were beaten 3-0 at Old Trafford.
Our sentiments exactly. But it seems some do care. We have lots of mails about Tim Sherwood (he's not popular) as well as HIT IT, TENNIS and other variations...
The MC isn't convinced Joleon Lescott is what Man United need at the moment, but that's one suggestion in the morning mailbox. Plus, plenty of moaning from Spurs fans...


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Cigarette Smoking Strongly Modifies the Association of LOC387715 and Age-Related Macular Degeneration The American Journal of Human Genetics, Volume 78, Issue 5, 1 May 2006, Pages 852-864 Silke Schmidt, Michael A. Hauser, William K. Scott, Eric A. Postel, Anita Agarwal, Paul Gallins, Frank Wong, Yu Sarah Chen, Kylee Spencer, Nathalie Schnetz-Boutaud, Jonathan L. Haines and Margaret A. Pericak-Vance Abstract We used iterative association mapping to identify a susceptibility gene for age-related macular degeneration (AMD) on chromosome 10q26, which is one of the most consistently implicated linkage regions for this disorder. We employed linkage analysis methods, followed by family-based and case-control association analyses, using two independent data sets. To identify statistically the most likely AMD-susceptibility allele, we used the Genotype-IBD Sharing Test (GIST) and conditional haplotype analysis. To incorporate the two most important known AMD risk factors—smoking and the Y402H variant of the complement factor H gene (CFH)—we used logistic regression modeling to test for gene-gene and gene-environment interactions in the case-control data set and used the ordered-subset analysis to account for genetic linkage heterogeneity in the family-based data set. Our results strongly implicate a coding change (Ala69Ser) in the LOC387715 gene as the second major identified AMD-susceptibility allele, confirming earlier suggestions. This variant's effect on AMD is statistically independent of CFH and is of similar magnitude to the effect of Y402H. The overall effect is driven primarily by a strong association in smokers, since we observed significant evidence for a statistical interaction between the LOC387715 variant and a history of cigarette smoking. This gene-environment interaction is supported by statistically independent family-based and case-control analysis methods. We estimate that CFH, LOC387715, and cigarette smoking together explain 61% of the population-attributable risk (PAR) of AMD. The adjusted PAR percentage estimates are 20% for smoking, 36% for LOC387715, and 43% for CFH. We demonstrate, for the first time, that a genetic susceptibility coupled with a modifiable lifestyle factor such as cigarette smoking confers a significantly higher risk of AMD than either factor alone. Abstract | Full Text | PDF (1498 kb) |
This Month in the Journal The American Journal of Human Genetics, Volume 77, Issue 3, 1 September 2005, Pages i-ii Kathryn Garber and Robin E. Williamson Full Text | PDF (131 kb) |
Factor H family proteins and human diseases Trends in Immunology, Volume 29, Issue 8, 1 August 2008, Pages 380-387 Mihály Józsi and Peter F. Zipfel Abstract Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins. Recent evidence shows that factor H family proteins (factor H and CFHRs) are associated with diverse and severe human diseases and are also used by human pathogenic microbes for complement evasion. Therefore, dissecting the exact functions of the individual CFHR proteins will provide insights into the pathophysiology of such inflammatory and infectious diseases and will define the therapeutic potential of these proteins. Abstract | Full Text | PDF (514 kb) |
Copyright © 2005 The American Society of Human Genetics All rights reserved.
The American Journal of Human Genetics, Volume 77, Issue 3, 389-407, 1 September 2005
Johanna Jakobsdottir1, Yvette P. Conley2, 3, Daniel E. Weeks1, 2, Tammy S. Mah4, Robert E. Ferrell2 and Michael B. Gorin2, 4, ,
1 Department of Biostatistics Graduate School of Public Health, Pittsburgh
2 Department of Human Genetics, Graduate School of Public Health, Pittsburgh
3 Department of Health Promotion and Development, School of Nursing, Pittsburgh
4 UPMC Eye Center, Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh
On the basis of genomewide linkage studies of families affected with age-related maculopathy (ARM), we previously identified a significant linkage peak on 10q26, which has been independently replicated by several groups. We performed a focused SNP genotyping study of our families and an additional control cohort. We identified a strong association signal overlying three genes, PLEKHA1, LOC387715, and PRSS11. All nonsynonymous SNPs in this critical region were genotyped, yielding a highly significant association (P < .00001) between PLEKHA1/LOC387715 and ARM. Although it is difficult to determine statistically which of these two genes is most important, SNPs in PLEKHA1 are more likely to account for the linkage signal in this region than are SNPs in LOC387715; thus, this gene and its alleles are implicated as an important risk factor for ARM. We also found weaker evidence supporting the possible involvement of the GRK5/RGS10 locus in ARM. These associations appear to be independent of the association of ARM with the Y402H allele of complement factor H, which has previously been reported as a major susceptibility factor for ARM. The combination of our analyses strongly implicates PLEKHA1/LOC387715 as primarily responsible for the evidence of linkage of ARM to the 10q26 locus and as a major contributor to ARM susceptibility. The association of either a single or a double copy of the high-risk allele within the PLEKHA1/LOC387715 locus accounts for an odds ratio of 5.0 (95% confidence interval 3.2–7.9) for ARM and a population attributable risk as high as 57%.


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Watch Gerson on this week's "Para Que Lo Sepas" commentary, which airs on NY1 Noticias every Monday at 5 PM and runs every hour through Tuesday until 5 PM.
More Kelly Missteps?
By Gerson Borrero
New York, NY, February 2, 2012
The nearly fatal shooting of 29 year old Police Officer Brennan, of New Hyde Park, N.Y., in the line of duty Tuesday night on the premises of a public housing development in Bushwick, Brooklyn made it abundantly clear the risk that New York's Finest face each minute of the day.
By all accounts, PO Brennan should be dead. The point-blank shot allegedly fired to the back of the head by suspect, 21 year old suspect Luis Ortiz, should have added a widow to the extended family of the NYPD and left a baby girl to grow up reading about how her Daddy was gunned down by a habitual criminal.
"The officer, when I visited him this morning, was going in and out of consciousness," said Police Commissioner Raymond W. Kelly in a Press Conference on Wednesday. "That's because of the morphine, I'm told. As we said last evening, he is extremely lucky." And hours after trauma surgeons had removed the bullet from the base of the PO Brennan's skull, he remained at Bellevue Hospital Center in critical but stable condition. The investigation by detectives is on going.
In the meantime, we wonder if, unfortunately, this officer was shot by a bullet from his own gun?
According to a retired NYPD detective, told TBR that, "The bullet held-up by Kelly at the press conference appears too big to be a .38 cal. which was the type of gun recovered from an area near the suspects residence."
Our source also noted: "That was the first time I have ever seen a bullet recovered from an officer being displayed to the press!"
The former detective expressed the following concern to TBR, "I wonder how they now handle the "chain-of -custody" issue? Usually, a doctor will hand over a recovered bullet to an officer or the detective handling the case. They, in turn, voucher it and are able to testify, at a later date, that it was the same bullet recovered by the doctor."
Which in this instance, raises the question as to whom the doctor may have given the bullet to?
Did the doctor who removed the bullet give it to the person standing behind Commissioner Kelly and who handed it to Mr. Kelly at the press conference? After holding the bullet up so that cameras could capture the visual, the Police Commissioner seems to returns the vial containing the bullet back to the same person.
Could the sequence of the handling of the bullet press conference have an adverse impact on the eventual case against the alleged shooter?
Obvious problems with the chain-of-custody may develop and an astute defense attorney can argue that, given all the people who handled the bullet, it is impossible to determine whether it was the same one removed from the officer," is what the retired detective told the Borrero Report.
We just hope that the ex-NYPD detective is wrong.
From our friend Mary Murphy at WPIX-TV
Suspect Who Fatally Shot NYPD Cop In Face In Custody
Wanted For The Murder of Police Officer Peter Figoski
At 2:15 this morning police officers from the 75th Precinct responded to a 911 call of a burglary in progress at 25 Pine Street in East New York reported by the owner there.
The owner, who resided on the first and second floors, reported hearing what he thought was a break-in in the basement apartment, occupied by a 25-year old tenant.
The first two officers to respond encountered a robbery victim and his neighbor in the basement apartment.
The two assailants, including the gunman, had tried unsuccessfully to flee from the rear of the location. Failing that, they hid in a side room as the first responding officers walked past them and began interviewing the tenant and his neighbor. The two suspects then made their way to the front door to escape.
Meanwhile, Police Officer Peter Figoski, who was part of the back-up team that responded, was at the bottom of the stairs leading from the street to the basement apartment door when he was shot in the face by one of two assailants.
His partner, Police Officer Glenn Estrada, was already struggling on the street level in front of the house with a second suspect, when he heard the shot and observed the gunman run by him.
Officer Estrada released the man he was struggling with and pursued the gunman, capturing him after a foot pursuit of several blocks at the corner of Fulton and Chestnut streets.
A sliver 9mm Ruger semi-automatic pistol was recovered under a parked car on Chestnut Street near Fulton Street. It appears that one round had been discharged from the weapon. The shell casing had stove-piped, or jammed, in the chamber of the gun. Ten live cartridges remained in its magazine.
We also recovered a black ski mask on the sidewalk about 15 feet from where the gun was found.
The tenant reported first hearing the two suspects pounding on the basement door, and then entering, as he went to the door to investigate. The tenant, an employee of a nearby bodega, said that there were two men, a male Hispanic and a male black who was wearing a ski mask. They initially claimed to be police officers, the tenant said. They then demanded money and jewelry. They knocked the tenant down, and one of the men struck him in the head with a firearm.
As he was lying on the floor of his apartment, he heard what he believed were police officers entering the location, a struggle, and then a shot ring out. The robbery victim said his assailants stole an inexpensive watch and $770 in cash. The tenant is currently being treated at Brookedale hospital for head injuries.
The gunman, Lamont Pride, 27, of Brooklyn, has 5 unsealed prior arrests, including several for drug possession and sale. Pride was wanted on an outstanding warrant for aggravated assault in North Carolina.
The second suspect ran from the scene and still being sought.
Officer Figoski has been an active police officer with over 200 arrests, nearly half felony arrests. He has 12 medals awarded, including 8 for exceptional police duty. We are all praying for him.
His partner, Officer Estrada, was also treated here at Jamaica for an injury to his right shoulder sustained in his confrontation with both suspects. I want to commend Officer Estrada, who had the presence of mind to focus on the man with the gun, and the courage to chase him down and capture him.
I also want to commend the staff here at Jamaica for their outstanding assistance to our officers tonight and for the great work they do in this community every day.
The New York City Police Department is asking for the public's assistance in identifying and locating the following individual who is a person of interest in connection with the Murder of a New York City Police Officer in the confines of the 75 pct.
He is described as a Male Hispanic, 24-30 years old. Black hair and light skin complexion.
Wearing a light colored T-shirt, and dark pants.
The individual was last seen walking Westbound on Fulton St from Chester St.
Click HERE for video.
Anyone with information in regards to the whereabouts of this individual is asked to call Crime Stoppers at 1-800-577-TIPS (8477). The public can also submit their tips by logging onto the Crimes Stoppers website at WWW.NYPDCRIMESTOPPERS.COM or by texting their tips to 274637 (CRIMES) then enter TIP577.
All calls are strictly confidential.
Arab Spring in the Caribbean?
New York, NY, October 27, 2011
Maybe the quest for freedom in the Arab world will remind US leaders that a group of their own citizens clamor for the right to self-determination.
At least one prominent American, former presidential candidate Patrick J. Buchanan, is aware of that clamor.
Recently, appearing with Curtis Sliwa on New York radio station AM970 The Apple, Buchanan, on to discuss his most recent book "Suicide Of A Superpower," said of the current political status in Puerto Rico:
"I believe that the Puerto Rican people should decide their own destiny.
I do not believe they should be made a state because I think then we would be required to become a bilingual country where you would have to have earphones and instant translation in Congress.
I think they are…they are of a Spanish culture and history and heritage, so what I would do as regard to Puerto Rico I would say, 'the statehood is out, the present Commonwealth status is fine if you want to keep it and if you want independence, if the...if you set-up an established way to elect and choose independence the United Stated will let you have independence and we will have permanent association.'
So, I am against statehood, I am in favor of the Commonwealth if they want to keep it, and I would agree to independence and nationhood for Puerto Rico if the Puerto Ricans wanted that. They have been good friends but there's no doubt we seized that island by force from Spain in 1898 as a result...as we seized the Philippines and eventually we let the Philippines go.
I don't think what we did in the Philippines was very just, incidentally, but we let...we did a wonderful job after that and we let them go and I think the Puerto Rican people should always have the right to be independent and free of the United States if a majority of them choose to do so."
Come on President Obama, how about some US assets to assist in that liberation?
Bush Redux
New York, NY, October 25, 2011
For those who may believe President Barack Obama announced something new or momentous in his recent statement that all combat troops would leave Iraq by the end of this year, we provide you the agreement between the United States and Iraq crafted during the George W. Bush administration. The document makes clear that the withdrawal of all US forces from all of Iraq had already been agreed to in 2008.
Agreement Between the United States of America and the Republic of Iraq On the Withdrawal of United States Forces from Iraq and the Organization of Their Activities during Their Temporary Presence in Iraq
State Senator Ruben Diaz, Sr. Calls For Unity
New York, NY, October 25, 2011
Open Memo to My Senate Caucus Colleagues
To: Members of the New York State Senate Puerto Rican/ Latino Caucus
From: Senator Reverend Ruben Diaz
Date: October 24, 2011
Re: Our Show of Unity
This memo is to congratulate my Senate colleagues who serve as Members of the New York State Senate Puerto Rican/Latino Caucus: Senator Adriano Espaillat, Chair; Senator Gustavo Rivera, Vice-Chair; and Caucus Members Senator José Peralta, Senator Martin-Malavé Dilan, and Senator José M. Serrano. I congratulate all of you for showing real unity on behalf of our Caucus and our community by not attending the so-called Legislative Hispanic Unity Conference that was organized by our Senate Majority (Republican) Leader Dean Skelos.
Most importantly, I have to admire our Caucus Chairman, Senator Adriano Espaillat for his leadership.
Christopher Columbus: A deadly and accidental tourist
By Miguel Sarmiento
Regardless of whether he was Jewish or Catholic, or how you may choose to refer to him—Christopher Columbus, in English; Cristoforo Colombo, in Italian; Christophe Colomb, in French; Christoph Kolumbus, in German; Christoffel Columbus, in Dutch; or Salvador Fernandez Cristóvão Zarcus Colombo, in Portuguese—the man died convinced that in each one of his trips
he was on his way to India and, contrary to the meaning of his name, he left behind a trail of pain and death unlike any other in human history.
Today, 519 years later, there are those who celebrate this accidental and bloody Caribbean cruise tourist, and there are those who wonder whether theactions of this individual and those of his subsequent minions will forever go unpunished.
His first name, Christopher, means "He who carries Christ within" and his last name, Columbus, means "Dove," known as the universal symbol of peace. This sailor did not in any way give justice to his namesake for in the name of his "Christ within," he committed what would undoubtedly be the equivalent of Crimes against Humanity if judged before the International
Court of Justice today.
His travels remind me of an advertisement slogan used to promote tourism to a Colombian city. That slogan stated, "A pleased tourist brings more tourists." Upon his return home, this clueless sailor expressed total satisfaction, and so much was he pleased that millions of Europeans followed his Pinta, Nina and Santa Maria to the Americas. Then they, in the name of several European Crowns, proceeded to commit the most egregious genocide that human history has ever witnessed.
In his journal, Columbus described the peoples of the continent he had landed on as follows: "They bear no arms and do not know what they are. I showed them a sword, and out of sheer ignorance, they held it by the wrong side and got cut ... They will make perfect servants ... With fifty men we can subjugate them all, and make them do whatever we please." Immediately after, Columbus took on the unspeakable task of enslaving and abusing the Natives.
Bartolome de las Casas—a holy man to some, to others a reporter of the atrocities committed by his countrymen, blinded by greed and endless ambition of wealth that by far exceeds that of today's Wall Street investors—in a 1552 report entitled "Brief account of the destruction of the Indies," told the Spanish Crown:
"Beyond Santa Marta and Cartagena, there is a land inhabited by once happy and good and passive people living in emerald and gold rich territories. To these provinces, named the New Kingdom of Granada- after the tyrant who first came to these lands who was himself a native of the kingdom of Granada, many wicked and cruel men came. They were expert butchers and shedders of human blood, very familiar and experienced in these sins also committed in many other parts of the Indies. Their wickedness has been immeasurable, and the aggravating circumstances such that they exceed those committed in all of the other Provinces combined. I beg Her Royal Highness receives and reads this brief report with the mercy and kindness with which Her Highness often treats the works of her subjects, for the public good and prosperity of the thy Kingdom. For after bearing witness and understanding the injustice placed upon those innocent peoples, who are being annihilated and torn without just cause or reason, but the mere greed and blind ambition of those committing such nefarious deeds, Her Highness must effectively plead and persuade His Majesty to deny whoever asks to embark in such harmful and detestable enterprise, to put an end and perpetually silence so much terror, that from now on, no one be bold enough and dares to ever act in such way after being so appointed."
New Granada, known today as Colombia- named after the sinister tourist, remains as indifferent to the subsistence existence and abuse of its original inhabitants, and its leaders acting as the conquerors of which Bartolome de las Casas speaks of.
It is difficult to understand why so many countries celebrate the encounter of these two worlds. We should instead declare this day, one that will live of infamy, a day to mourning. It is difficult to understand why we have parades and our nations celebrate it. For instance, in Costa Rica it is called the 'Day of the Cultures.' In Uruguay it is known as 'Day of the Americas'. Colombia, Chile, Argentina, USA and Mexico refer to it as 'Columbus Day' and the 'Day of Race.' Ironic, no? Perhaps we should call it 'The Day of the Annihilation of a Race.' At least in Venezuela they have a better and much more appropriate name for it; they call it 'The Day of the Indigenous Resistance.'
Perhaps it would be more appropriate to call it 'The American Holocaust' ... Or, better yet, following Christopher Columbus' Judeo-Christian roots, and what his name implies, we could call it 'European Day of Atonement, Reparations and Compensation to the Native Peoples of the Americas.'
The reason for the atonement is that Christ died on the cross to atone for mankind's sins...The problem with this solution is that there is not enough timber in the world to make a cross big enough to hang on it the sins committed by past and present conquerors.
Nevertheless, I agree with Chilean Nobel Prize winner, Pablo Neruda, when he wrote: "But from the barbarian's boots, from their beards, from their helms, from the horseshoes, like small pebbles... dropped bright and immaculate words that stayed and shined here ... the language. We ended up losing... We ended up wining ... They took the gold and lefts us the gold ... They took everything, and left us all... They left us... the words."
To which I say, Amen!
Nice Company!
New York, NY, October 5, 2011
Our friend Wayne Barrett of The Daily Beast has an excellent article describing the company Texas Governor and wannabe president Rick Perry keeps.
Like our abuelas would say "dime con quién andas y te diré quien eres" (tell me who you walk with and I'll tell you who you are).
Read Wayne's column here: "Perry's Other Hunting Buddies."
NAN and its Anti-violence committee to step up fight to eradicate horrendous culture of violence in NY.
According to Ms. Mallory, "The culture of violence has become an epidemic that is accepted to not only members of the community but by elected officials across the state of NY. No one has immunity from this issue. We must all do our part to end this genocide.
The National Action Network and Tamika D. Mallory have been on the forefront of speaking out against gun violence across the country and the organization has hosted "National Days of Outrage against gun violence" and partnered with the NYPD to host gun buyback programs. The violence, however, still rages on and NAN is urging community members not to sit back and bear witness while contributing to the demise of their own people.
The National Action Network is reaching out to the family of Tayshana Murphy to lend support in this difficult time and shed light on the travesty of gun violence and hosted the family of Denise Gay who was shot Labor Day weekend, allegedly by a police bullet.
Marty Markowitz Audio File
September 1, 2011
Click HERE to hear Marty's message.
"El Bloombito"
New York, New York August 29th, 2011
A bit of self-promotion, but check out this New York Observer story about the "Tweets" of a self-described "Jewryican."
GOVERNOR CUOMO ADVISES NEW YORKERS TO PREPARE FOR PROPERTY DAMAGE AND LOSSES AS HURRICANE IRENE APPROACFor Immediate Release: August 26, 2011
GOVERNOR CUOMO CONVENES EMERGENCY CABINET MEETING REGARDING HURRICANE IRENEt
For Immediate Release: August 26, 2011
Governor Continues Deployment of State Resources for Emergency Storm Assistance
Governor Andrew M. Cuomo today convened an emergency session of his Cabinet to review plans to protect New Yorkers and mitigate the potential effects of Hurricane Irene. The Governor is continuing to coordinate the state government-wide mobilization of resources to prepare for the storm.
On Governor Cuomo's orders, the following actions are being implemented immediately:
"We have moved quickly to initiate our emergency plans, to work with our federal and local partners, and to identify, prepare, and put into place one of the most aggressive activations of New York State government ever assembled in the face of a possible natural disaster," Governor Cuomo said. "We are fully committed and we are preparing for the worst."
Specific plans include:
The Triple Waltz
Cuomo-Christie & the NY/NJ Port Authority Continue Their "Dance"
New York, NY, August 18, 2010
Governors Andrew M. Cuomo and Chris Christie continue their phony "outrage" regarding the recently proposed Port Authority toll increases.
Now, they have the nerve to attempt to portray themselves as the knights that come to the "rescue."
Give us a break!
Read the letter they jointly sent to Port Authority honchos.
Those polled were asked, among other things, for a one word description of the governor, along with how he compares to other elected officials, including President Barack Obama, Mayor Michael Bloomberg and New Jersey Governor Chris Christie.
The poll will be released tomorrow in Albany.
One word description? If taken after the Port Authority toll increase debacle, they may well be four letter words!
Stay tuned...
New York, NY, August 8th, 2011
"Credit rating agencies are a critical gatekeeper in the financial markets; they are relied upon for the accuracy of their analysis." Barbara J. Johnson Alaska Pacific University
All of a sudden, after having played fast and loose with their ratings resulting in untold millions, if not billions, in profits for them, S&P wants to play it straight and call it as it sees it. Could it be atonement for past sins, or placing a death nail in the coffin of a president Wall Street has never wanted?
Read one of the conclusions from the Financial Crisis Inquiry Commission:
And the Password Is? "Grave Inconvenience!!"
New York, NY, July 23, 2011
As reported Thursday by the BorreroReport, same-sex couples hoping to get married on Sunday will have to receive a waiver, pursuant to section 13-b of the NYS Domestic Relations Law, of the usual 24 hour waiting period between the time a marriage license is issued and the time the actual marriage ceremony may take place.
However, it appears that to make absolutely sure that none of the couples walk away without being actually married (or that none of the politicians looking for photo-ops with all the new happily married gay couples are disappointed) the New York City County Clerk has placed, on-line, a fill-in the-blanks waiver application.
The on-line application does not ask the applicant the reason for requesting the waiver instead, in what many may call "coaching," the application is pre-printed with the reason why the waiver is requested. Paragraph 5 of the application states that the waiver is sought because the couples will suffer "Grave inconvenience."
Couples would be asked to provide a reason for requesting a waiver and, if it falls within the reasons contemplated by the Domestic Relations Law, they could be issued one by a judge.
Presumably, if section 13-b is followed, the couples would have to show that any of these conditions exists before obtaining the waiver,
- One of the parties is in danger of imminent death
- Reason of other emergency public interest will be promoted thereby
- Delay will work irreparable injury or great hardship upon the contracting parties or one of them
The Domestic Relations Law, however, is clear that "Grave inconvenience"is not one of the reasons for which a waiver may be granted.
So, with perhaps a bit more than a "wink-and-a-nod," the cookie-cutter form insures that each and everycouple requesting a waiver will be swearing on an oath that they are suffering "Grave inconvenience."
Hopefully, for those requesting the waivers, they will first read section 210.10 of the New York State Penal Law which, for their benefit, we re-print in its entirety:
§ 210.10 Perjury in the second degree.
A person is guilty of perjury in the second degree when he swears falsely and when his false statement is (a) made in a subscribed written instrument for which an oath is required by law, and (b) made with intent to mislead a public servant in the performance of his official functions, and (c) material to the action, proceeding or matter involved.
Perjury in the second degree is a class E felony.
"We are going to enforce the law - and any group that thinks they are above the law is sadly mistaken."
"If people obeyed the law, there wouldn't be any reason to sue..."
"The best thing would be people obeyed the law."
The quotes above, all by Mayor Michael R. Bloomberg, would have one believe that he would take a great interest in making sure all of Sunday's same-sex weddings are conducted by the letter of the law, yet, as a City hall spokesperson told
the BorreroReport yesterday as they washed their hands of the issue, "[t]he decisions on waivers are made by members of the judiciary.."
Obey the law? You decide.
Hizzoner's Marriage Foul-Up
City Hall claims marrriage waivers are "routinely" granted by judges
New York, NY, July 21, 2011
On Tuesday, weeks after the NYS Senate approved changes in the Domestic Relations law allowing for same-sex marriages, Mayor Michael R. Bloomberg and City Council Speaker Christine C. Quinn, held a joint press conference announcing the creation of a lottery system for couples wanting to be among the first to be married when the law takes effect on July 24th.
According to the Mayor's press release, judges will also be available to "review requests to waive the 24-hour marriage waiting period normally required under State law." The press release, however, makes no mention of the strict requirement in the state law under which such "waivers" may be issued.
A review by the BorreroReport of Section 13-b of the New York State Domestic Relations law reveals that waivers to the 24 hour waiting period after a marriage license is issued, may only be granted if certain specific conditions are met by the couples wishing to marry.
- Delay will work irreparable injury or great hardship upon the contracting parties, or one of them
Assuming the judges who preside over Sunday's much anticipated same-sex ceremonies follow the law, it appears few, if any, same-sex couples will actually be married that day.
In their quest to score political points with what many perceive is a powerful and influential special interest group, Bloomberg and Quinn may very well, literally, have left them at the altar.
Check out Gerson with Curtis Sliwa at the end of this funny David Letterman clip.
Letterman Video


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