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Due in December 2012 Chat thread #3
Started by
, Apr 10 2012 07:51 PM
131 replies to this topic
#2Posted 10 April 2012 - 07:55 PM
GOLD!! Woo hoo! I'd do the list but I'm on my phone! If someone else wants to do it then that would be great otherwise I'll do it when I'm back on the computer.
Quick post to say YAAAAAAAAAYYYYYY yipfazel!! That's fantastic news and must be such a relief!! #3Posted 10 April 2012 - 07:59 PM
Silver! Woot
#4Posted 10 April 2012 - 08:00 PM QUOTE (youngyummymummy @ 10/04/2012, 06:01 PM) <{POST_SNAPBACK}> I was also wondering if anyone could tell me what they think about working. I know ts only early stages but I dont know whether to tell my boss as soon as its confirmed as I work in a petrol station in the cafe section so I am on my feet all day exposed to the fuel so im not too sure if thats good for the baby? Or I may just being paranoid! My reasons differ to yours but I told my boss pretty much straight away. Mainly because I thought being pg might start affecting my work - nearly every day last week at around 3pm I was literally nodding off at my desk! There were also a few days where I had horrible back ache so was able to work from home. My company is very supportive of mothers / women in general so I felt very comfortable chatting to him about it this early on. Not sure about the petrol fumes thing - best thing to do would be to have a chat to your GP/OB to find out if there are any risks given your exposure level #5Posted 10 April 2012 - 08:05 PM
Just catching the thread. Back tomorrow! Happy zzzzz to all!
#6Posted 10 April 2012 - 08:14 PM
Hi everyone, just thought I'd join in, according to my dates I'm due 18th dec.
My first bub is 20months, but I swear I'm more terrified this time around. Wishing all a successful rest of the year. #7Posted 10 April 2012 - 08:18 PM
Hi All! Especially to 123abc and youngyummymummy and congratulations!
Great work on the list TheSame, looked so much better than my poor first effort - and it would be great if you could do it this time Andrea - that way we are all sharing it around Yipfazel awesome you heard a heart beat. Youngyummymummy I haven't told my work yet, hoping to hold out until my first Ob appt at 10.5 weeks - I am the tail end of a huge project and really want the focus to be on our work and achievements - not on the fact I will be the third pregnancy in a team of 7 in the space of 6 months. But with your work, maybe not a bad idea - especially if you have a good relationship with them. Sleep well tonight everyone - may the insomnia leave us all alone. #8Posted 10 April 2012 - 08:38 PM
Hi everyone!
Oh my goodness I have failed to respond to a whole thread - but I have read it! There is like a gazillion of us. Welcome anikal! sorry for lack of personals I will try and keep up better in the future. full time work keeps interrupting my eb life. last pregnancy i could log on from work but they have banned us no! no fair! AFM - I am sick! threw up on myself in the car sunday - yuk. threw up this morning too. ugh. one of my team asked me if i was hungover today -lucky i could say nope its the baby. i have told a few people, i would like the support if something goes wrong and i guess im of the view that miscarriage shouldnt be so shrouded in mystery - its not like we have done something wrong! but i totally understand if people want to keep it private - people need to deal with heartache their own way. i am in canberra (originally from wollongong) its so so cold here already. trying to avoid putting the hot water bottle on my belly but so want too. i have dating scan on 21 april - cant wait. even though this is my second pregnancy im so much more worried this time. not sure why. feel like i cant be so lucky twice round which is silly i know. anyway, symptoms here are rife - exhausted, moody, crampy, vomity, gassy - i know its good but it sucks as well. starting taking ginger tablets - and i hate it repeating on me. also have that constant hungry but dont know what i want to eat dilemma which is driving my husband crazy. ok i better stop rambling! Hope everyone is well and babies are sticky! xxxx #9Posted 10 April 2012 - 09:00 PM
Woah woah woah, new thread already!!!! I went back to find the list and post it... For those who are new we decided that the first person to post in the new thread posts the list (or whoever is able to - just copied and pasted from previous thread, adding any updates).
DECEMBER 2012 BABIES!!!!!! Gisses DD 11months #2 due early December 1st December: Nicole83- DS1=6, DS2=4 (almost), DS3=2, #4 MaxandMe- 34, DH 28 DS 19 months #2 hushlittlebaby- 38, DH35 2 kids 15 and 11 #3 2nd December MahnaMahna- DH, DD, DS #3 Yipfazel- 32, DP 45 #1? Trifecta- #3 MahnaMahna - DH, DD, DS, #3 Keshena - DS1=14mnths, #2 Mummy Again2 - 37, DH 41, DS 8, DS 6, #3 grasshopper10- DH, #1 3rd December Hollag26 -#1 Pssst - 36, DH=37 DD=17 months, #2 Guessing girl! Micaela13 muzbilove - DS1=17, DD1=15, DD2=3, DS2=15 mnths, #5 4th December LadyChattalot- 36, DH 36 DS=23 months, #2 Guessing Missy78 33, DP 39, #1 MrsT43 5th December thesame 35, DH 37, DS1, #2 (surprise) LJA79 sparrowfall 33,DH 36 DSS 2.5 PG#1 MrsLightyear 6th December aurora sleeping- 30, DH 33, DS 18 months, #2 (and #3?) - Surprise(es) Miss Monica- 37, DH 37, DD=5, DS=2, #3 KiwiMelW - 28, DH 27, #1 7th December MrsPotatoHead - 26,DH 30, DS1=4, DS2&3=1, #4 Oh Dear DS10, DD7, DD3, #4 8th December JuniorGandR- 33, DH 33, DD 21 months, #2 Guessing Andrea79- 32, DH 34, DS 2yrs 8 mths, #2 JustDance- 33, DH 35, DS 18 months, #2 mcchickies - DH, DD1, DD1, DD3, #4 9th December Mumlucky3- DD 9, DS 7, #3 butterflydreaming- 29, DH 43, DS 2, #2 10th December Teenybopper- 32, DH 35, #1 Cuddlesnkisses- DD 4, #2 Zingiber- 37, DP 46, DSD=17, DSS=15, #1 11th December youngyummymummy- 20, DP, #1 12th December Amy26- 30, DP 33, DS 4, #2 mandy303 - 27 cosmic79- 34, DH 44, DS1 10, DS2 6, #3 thunda - DH, DD, DD, DS, #4 Girlwonder1- 36, DH 37, #1 abc_123 - #1 13th Decmber Lilybeth - DS 20 mnths, #2 Red nut- 38, DP 41, #1 14th Decmber Ally04 - 26, DP 26, DS 6, DS 4, #3 utopia_deb organic~sab - DS 1, #2 15th Decmber SarahBubble - 32, DH 33, DD 22 mths, #2 16th Decmber Retro_Mumma - DH, D?, #2 maggiechunga - #2 Balance25 - DS 15 mths, #2 17th Decmber Kristy81 - 33, DH 31, DS 22 mths, #2 18th Decmber anikal - D? 20 mnths, #2 20th Decmber klee102 - DS 12, DD 11, DSD 5, DD 18 mnths, #4 22nd Decmber ruthlet - DD 8 mnths, #2 3beautifulDS - 31, DH 30, DS 6, DS 4, DS 2, #3 23rd Decmber Tiken - DH, DD 3, DS 1, #3 24th Decmber NingaGal78 - 33, DP, DS 9, #2 25th Decmber - Christmas Bubbas!!! Chloejames88 - 23, DP 25, #1 Eeyolet - DS 4, DD 19 mths, #3 EDD TBC: emiboo Ducki151 - DH, DD 7, #2 dreamingofcats - 25, DH 29, #1 Angelbabies - gone but not forgotten. Hope to see you in another DIG soon. xxx Rach_B LittleJacksonOne kellymuppet _____________ Cosmic, yep feeling presumptuous too. I want to tell people but still feel weird about saying it's happening when I feel like it's still not real yet!!!! yip YAAAAAAAYYYYY!!!!! So glad all is okay!!!! Hi to the newbies!!! youngyummymummy your workplace has to provide you with a safe place to work while you're pregnant by law - not sure where to get that kind of info, but if you're anywhere where it's dangerous to you or bub they must provide you with a position that you can continue working in safely. Someone else would have a better idea about this than me though... Oh MaxandMe that sucks!!! Good signs though! I have been getting baaaaaad gas, it's just awful. And scary when it gets a bit painful and I think it's bad news for the bubba, only to go to the bathroom and realise it's my bowels instead. Ugh. AFM - Counting down the days as we all are. Hurry up dating scan!!! Still 2 weeks to go... Edited with recent updates I could find - PM me if you have more. Thanks for making the list so pretty and organised thesame. Edited by aurora sleeping, 15 April 2012 - 11:58 PM. #10Posted 10 April 2012 - 09:15 PM
Can I join in? We had a BFP today and it's still feeling very surreal. Our DD is 8 months old. Based on my charting dates, my due date would be 22 Dec.
Wishing everyone happy, sticky little babies. #11Posted 10 April 2012 - 09:26 PM
Hi Ladies! The group seems to be huge already but do you mind if i join in too?
We have had a suprise BFP and have a new bub due 7th dec. It was a huge shock to me, i remained in denial for a few days, then i was a little angry, then sad and now i think i'm a little excited We already have DS10, DD7 & DD3 so will be our #4 I haven't had any tests done yet, we are fairly rural so not easy to get in there. I will try to get in next wk and have bloods, get referals etc. Look forward to getting to know you all over the next 8 months! #12Posted 10 April 2012 - 09:29 PM
welcome Ruthlet. And everyone else that has come on board since I first posted.
Youngyummymummy I second what Aurora sleeping said. Gosh, I am soo tired! Feeling a bit bloated otherwise but that's about it. DP reckons that my tastes are leaning towards savoury currently. And that I am talking in my sleep. I asked my sister and she had 3 pretty easy pregnancies so I have my fingers crossed. We have told close family (my Dad, sister, DP's Mum) but they are sworn to secrecy as DP and I (and some of DP's relatives) all work together. I am not planning on telling my boss until way after the first trimester. Really don't wish for him to hear through the grapevine - only started in this department earlier this year, and really love my job and boss. I am also trying to get a few training courses out of the road (doing a diploma, wanting to start some post-grad stuff) before I go on maternity leave. It's been a couple of weeks since the BFP and I still feel like someone is going to turn around and tell me it was all a big mistake. Can't wait for the first scan to see something! #13Posted 10 April 2012 - 10:46 PM
Hi, well done on the list making, you missed me out, I'm 37, DH 41, DS 8, DS 6 and now due 2nd Dec.
Nice to hear everyone's news. Will not likely be posting to much in the way of updates, working full time and with the two kids alreadyI don't have a lot of free time, but I will be popping in to see how everyone's doing and asking the odd question I'm sure. So far not anything very interesting to report, Take care all, M #14Posted 11 April 2012 - 12:43 AM
Hello all expectant mums,
I got my yesterday ( 9/04). Complete shock to both of us . This will be our first. Apart from the excitement, all the nerves have kicked in to. I have already seen the GP today for my first initial consultation. Now just waiting for my blood results. My EDD is 25/12 and so far i haven't seen many symptoms. I have tender boobs but no nausea. I'm not overly hungry, quite the opposite. My partner did tell me my belly felt like it was on fire but i do not recall being hot. Oh and I'm 23 and my partner is 25. I have read some of the previous bloggers and seen some sort of code for describing people or children but i havent quite caught on. Most importantly im very excited about my pregnancy and can not wait to have my first scan. #15Posted 11 April 2012 - 06:49 AM
Hi all
Thank you for your shared joy, it was awesome to see the little tyke still clinging on & heart beat nice & strong. After all four pregnancies ending in miscarriage and have all my hopes pinned on this one sticking & being a healthy child. I'm hoping the others are looking down & sending good wishes, it's been a hell of a time the last few years. To our newcomers, wow we seriously got some nookie in March didn't we?! I wonder if the other groups are just as big as ours? Young mummy mummy: technically by law you don't have to inform your employer until you are giving intent to go on maternity leave which is usually at 6-7 months. There is nothing wrong in telling your employer earlier if you are concerned about certain work tasks such as heavy lifting, dangerous fumes or goods. After you tell them they can't sack you for getting pregnant, you might want to go to www.fairwork.gov.au and look up the relevant details. Also check your organizations EBA regarding maternity leave. Max & me: I've only done tiny spews myself, more dry reaching than anything else. the whole car trip up & down a mountain on the Easter break I was chewing on dry crackers to stop me from vomiting. Have you tried dried crackers? Also Vegemite on toast is great in the morning to stop the early morning spews. So I have and haven't told work yet, I work for myself, so I guess my boss knows I haven't told my key clients yet. Though I've been working for one client more regularly than others and they would be blind not to see my little belly forming. Thinking of telling them sooner than planned,because I can't hide it anymore. After 4 miscarriages it's difficult to tell everyone and they be all excited then feeling like you've let people down. Wishing us all sticky days ahead. #16Posted 11 April 2012 - 08:16 AM
yipfazel Fantastic news, what a relief for you!!
Chloejames88 this helped me, i was lost with all the codes! http://www.essentialbaby.com.au/forums/lof...hp/t529892.html Welcome to all the Newbies! #17Posted 11 April 2012 - 08:34 AM
Thanks again for the list! Further details for me, DP 41, birthday Dec 18th, so hope bubs isn't a late one! Though my birthday is the day before my father's and that's actually been kinda nice over the years. Nowadays the nieces and nephews love getting to 'help' blow out the candles twice. Me, 38, and looking at the list the geriatric of the group, especially as this is number one! Not really by choice, spend my best breeding years with the exH, who whilst wasn't really Mr Wrong, was in the end Mr not quite right. Looking at where I was 2 years ago, feeling very lucky to be where I am today. It does add to my paranoia though, if anything goes wrong with this pregnancy I' m running out of time, and I'm aware of the higher rates of pretty much everything going wrong. Hope that doesn't sound like a whinge, just can't believe how blessed I am at the moment, which makes me a bit nervous that things can't stay this good. Dying for my first chuck just to make me feel reassured!
Yippee for yip's news, and hoping for as many stickies with possible in the group. 'only' about 6 weeks before we start getting the first of us to the lovely 12 week mark. #18Posted 11 April 2012 - 09:23 AM
Morning all....I slept almost the whole way through the night last night and guess what...bad mood GONE!
D says I have to get off the internet...I started stressing yesterday about having not taken vitamins before conception and by the time he got home from work had managed to convince myself via Dr Google and remembering 'that one day in January' that i didn't eat any greens that the baby will have spina bifida or something else. I'm being paranoid aren't I? Rednut - There are a few of us 'oldies' who are having #1. Being 37 and this being #1 and unplanned I am the same....constantly obsessing about all the things that are now at an increased risk (see above). I'm very fit and healthy but I still can't deny that number.....37. I'd love a bout of morning sickness too because now that i'm not tired or grumpy, all i've got to remind me of what is going on is mildly sore boobs...and that's not enough! No doubt in a few weeks it will probably hit me like a brick wall and i'll regret what i wished for! #19Posted 11 April 2012 - 09:49 AM
Ladychatalot - Thanks for the advice, I might suggest that we try that for the upcoming Labour Day long weekend. Gisses - The appointment is this morning, I will report back later Welcome and Congrats Youngyummymummy, Abc_123, Girlwonder1, Anikal, Ruthlet, Ohdear and Chloejames88!!! Yipfazel - Yay, so happy to hear it was good news. That's all for me for now, need to get my son organised for his aunty who is watching him while I go to my GP appt. Also have to renew my license today and all I can think is how awful my hair is with it's numerous greys and desperately needs colouring...oh well. I do plan on getting it done next month when I can afford to, I have been told it is ok and there is no proof of any ill effects towards bubs...anyone else have any info on that? Back later x #20Posted 11 April 2012 - 12:40 PM
Hi everyone , I thought I'd better stop lurking and introduce myself.
We got our last Wednesday and if my dates are right I'm due on the 5th December. I can't belive how big the December DIG is already! Hope everyone is well and we all have an uneventfull wait till our babies arrive I don't have a computer so i might not post much but i will be reading on my phone and trying to keep on touch. #21Posted 11 April 2012 - 12:45 PM
Hi All!!
Wow, this group is growing so fast, I can barely keep up with the threads!! Yip - so happy to hear that everything is ok and bubs has a nice strong heartbeat. I'm booked in for a scan next Tuesday (6wks 1day) so I'm praying like crazy that I get to see that little bean throbbing on the screen! I'm taking my hubby with me, cos I'd feel so guilty if I got to see it for the first time without him. He's so excited, bless him. Sorry about the lack of personals, am crazy busy at work and have just spent over half an hour catching up with the thread! Well, I had an early scan yesterday (5wks 1day) and got to see the gestational sack and the yolk sack, but no baby yet. It was such a relief to know that it was in the right place and the doctor said it all looked perfectly normal so fingers crossed! She told me to come back next week and we should be able to confirm a heartbeat.... I'm counting down the sleeps!! Not many symptoms yet unfortunately. Just the sore boobs mainly (which some days are more sore than others and it freaks me out a little when they're not as sore!!) The pregnancy insomnia is killing me. Haven't slept a wink the last 2 nights and I am beyond exhausted. Oh and I've been getting reflux after meals as well. I didn't think the reflux would start this early?? It's horrible!! I'm waiting for the MS to kick in so that I actually FEEL pregnant.... hopefully next week Oh and DH and I are going to Europe for a month between 10 and 14 weeks so I'm a little concerned about that as well. I will be having our NT scan in a private hospital in London (already booked) but I'm really concerned about not being in total control of my diet for a whole month! To make things just a little more difficult, I'm gluten free, so as much as I'm looking forward to the trip, I'm dreading every meal time! We've decided we're not telling a soul until we get back and can confirm that the baby is still ok. So our families and friends won't know until we're 14-15weeks!! #22Posted 11 April 2012 - 02:19 PM
Teeny Bopper I have had reflux the past couple of days too.
We just got back from the OB and we saw the heartbeat!! Most amzing thing. Can't wipe the smile off my face.......except for when the wave of nausea comes over me #23Posted 11 April 2012 - 02:36 PM
Told DH parents last night. They were ecstatic, Im pretty sure DH father was a tad emotional as its their first grand child. I am telling my Mum tonight.
I am not however telling my Dad. He has a massive family and he has been waiting for this for so long that I know that if i tell him he wont be able to keep it a secret at all (which I dont blame him!). So I'm going to wait till I have had the scan to test for downs. If everything is ok I will tell him that evening and no doubt my entire family on his side, which is massive by the way, will know not too long after that. however after telling DH parents last night, I feel so much more anxious of something going wrong. Its not just us who will be disappointed now. But i am keeping good positive happy thoughts #24Posted 11 April 2012 - 03:24 PM
Yip - I am so glad to hear your scan went well.
I have my dating scan tomorrow. I should be roughly 6 weeks and 4 days so am hoping to see a heartbeat, I know I will be majorly stressed if I don't. I have bad reflux, some MS, mostly before I eat (when I am starving) and after I eat for a bit. I also have extremely sore boobs so my symptoms are comforting in that I know something is going right down there #25Posted 11 April 2012 - 04:37 PM
I'm going to apologise in advance - there is no way I will be able to keep up with this thread! There's so many of us!
I'm booked in to the GP tomorrow night to organise bloods and a scan. My first pregnancy was an ectopic pregnancy so I want to get an early scan done to make sure that bub is in the right spot. Does anyone know what the earliest is that a HB can be found? Is it 6-7 weeks? I don't want to stress myself unecessarily if I go for an early scan and no HB is found. Revised EDD - 12th Dec I mixed up my LMP dates. Baby brain kicking in already 1 user(s) are reading this topic0 members, 1 guests, 0 anonymous users |
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Concealed blade safety knife featuring an adjustable blade positioning design which allows for 4 cutting points on a single-edge utility blade. Highly productive, it delivers 4x's more cuts than a single-edge, fixed blade "gooseneck" safety knife.Pattern
Product Information
• Concealed blade safety knife featuring an adjustable blade positioning design which allows for 4 cutting points on a single-edge utility blade• Highly productive, it delivers 4x's more cuts than a single-edge, fixed blade "gooseneck" safety knife.
• Uses the OLFA SKB-10 blade, a single-edge blade featuring 1 blunt edge for safer handling.
• Versatile, it features a 5/32" (4mm) throat inlet to cut.
• Acetone resistant for easy cleaning.
• Fits both right- and left-handed users with no blade adjustment necessary.
• Tool-free blade change.
OLFA® Satisfaction Guaranteed Policy
OLFA cutter & non-disposable scraper handles, locking mechanisms, and 9mm standard duty blades, 18mm heavy duty blades, 25mm extra-heavy duty blades, safety and trapezoid-shaped blades and scraper blades are subject to the World Kitchen d/b/a/ OLFA - North America satisfaction guaranteed or replacement policy.*
If at any time you are dissatisfied with these "Satisfaction Guaranteed" products, World Kitchen d/b/a/ OLFA - North America will provide an equally valued replacement. Please allow 4 to 6 weeks for delivery of replacement product. Should you be dissatisfied with any such product, please keep it. You may be asked to return it. Please contact our Consumer Care Center for warranty claims.
*PLEASE NOTE: This Policy does not apply to OLFA TouchKnife®, OLFA scissors, OLFA mats, OLFA rulers, disposable OLFA multi-purpose scrapers, all styles and models of 18mm, 28mm, 45mm, 60mm, rotary cutter replacement blades, and all styles and models of "KB" art knife replacement blades.
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The shower was held at a local inn and I really made an effort to incorporate the Breakfast at Tiffany's theme into everything. We started the shower in the morning so that we would be able to serve our guest breakfast. The menu included waffles and the bride's favorite eggs benedict.
For the tables we alternated the centerpieces between large champagne glasses (filled with ginger ale) and Tiffanys bags. Both were decorated with pearls. We were also lucky that the inn offered a Tiffany blue color as a napkin option!
Rather than a cake we did mini cupcakes in chocolate and vanilla. These were done by 5 Bites Bakery in Wellesley, MA. I love how the bakery matched the Tiffany blue and had the fondant bows!
Since the cupcakes were mini we did two for each person.
And of course for the favors I made cookies. I went with the a Tiffany's Box design and kept it simple. I used the #104 tip to create the ribbon affect with the icing.
The favors were bagged and displayed on the same table as the cupcakes.
Throughout the dinning room we had Tiffany boxes and posters from the movie. We did a Bridal Bingo game during gifts and gave out Breakfast at Tiffanys mugs, reusable bags, and a Audrey Hepburn bobble-head!


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Summary: Translation-initiation factor 2
Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.
The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.
This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
Translation-initiation factor 2 Provide feedback
IF-2 is a translation initiator in each of the three main phylogenetic domains (Eukaryotes [1] Bacteria [2] and Archaea [3]). IF2 interacts with formylmethionine-tRNA, GTP, IF1, IF3 and both ribosomal subunits [2]. Through these interactions, IF2 promotes the binding of the initiator tRNA to the A site in the smaller ribosomal subunit and catalyses the hydrolysis of GTP following initiation-complex formation [2].
Literature references
Aury JM, Jaillon O, Duret L, Noel B, Jubin C, Porcel BM, Segurens B, Daubin V, Anthouard V, Aiach N, Arnaiz O, Billaut A, Beisson J, Blanc I, Bouhouche K, Camara F, Duharcourt S, Guigo R, Gogendeau D, Katinka M, Keller AM, Kissmehl R, Klotz C, Koll F, Le , Nature. 2006;444:171-178.: Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia. PUBMED:17086204 EPMC:17086204
Hedegaard J, Hauge M, Fage-Larsen J, Mortensen KK, Kilian M, Sperling-Petersen HU, Poulsen K;, Microbiology. 2000;146:1661-1670.: Investigation of the translation-initiation factor IF2 gene, infB, as a tool to study the population structure of Streptococcus agalactiae. PUBMED:10878130 EPMC:10878130
Falb M, Pfeiffer F, Palm P, Rodewald K, Hickmann V, Tittor J, Oesterhelt D;, Genome Res. 2005;15:1336-1343.: Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis. PUBMED:16169924 EPMC:16169924
External database links
Pseudofam: | PF11987 |
This tab holds annotation information from the InterPro database.
InterPro entry IPR023115
Initiation factor 2 (IF-2) is one of the three factors required for the initiation of protein biosynthesis in bacteria. IF-2 promotes the GTP-dependent binding of the initiator tRNA to the small subunit of the ribosome. IF-2 is a protein of about 70 to 95 kDa that contains a central GTP-binding domain flanked by a highly variable N-terminal domain and a more conserved C-terminal domain. Some members of this group undergo protein self splicing that involves a post-translational excision of the intein followed by peptide ligation.
The function of IF-2 in facilitating the proper binding of initiator methionyl-tRNA to the ribosomal P site appears to be universally conserved, with an IF-2 homologue (aIF-2) present in archaea bacteria [PUBMED:10200264] Methanopyrus kandleri.
This entry represents the domain 3 of IF-2. It consists of a alpha/beta/alpha structure with a core formed by a parallel beta-sheet of 4 strands [PUBMED:11114334].
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
Loading domain graphics...
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (243) |
Full (5391) |
Representative proteomes | NCBI (4288) |
Meta (2608) |
Jalview | ||||||||
PP/heatmap | 1 | |||||||
Pfam viewer |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
Format an alignment
Download options
We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
Seed (243) |
Full (5391) |
Representative proteomes | NCBI (4288) |
Meta (2608) |
Raw Stockholm | ||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
External links
MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Seed source: | pdb_1z9b |
Previous IDs: | none |
Type: | Domain |
Author: | Mistry J, Gavin OL |
Number in seed: | 243 |
Number in full: | 5391 |
Average length of the domain: | 108.80 aa |
Average identity of full alignment: | 42 % |
Average coverage of the sequence by the domain: | 13.02 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details: |
Model length: | 109 | ||||||||||||
Family (HMM) version: | 3 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
Sunburst controls
ShowThis visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
Tree controls
HideThe tree shows the occurrence of this domain across different species. More...
Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the IF-2 domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
Loading structure mapping...


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Hey most of my engineering class is having an issue where after you login your screen goes blank or do anything on the student autodesk but some downloaded it a week ago no problem. I am just wandering what is causing this is it that the sever is down or are they updating everything it just we need the three year student code to work at home cause our shool has one small computer lab with all this on it and it just really makes it a pain not having at the house. and when will it be fixed if anyone knows.
What is "student Autodesk"?
Are you referring to the Autodesk Student Community website http://www.autodesk.com/edcommunity
or are you referring to starting your Autodesk student product (AutoCAD)?
More information is needed. Include screen shots.
I am having the same issues I get a blank screen when I want to get to the estudent community page. I want to download the program and that's all I get, please advise.
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Leatherback At Risk of Extinction Resources and Info Kit
E-Press and Information Kit Key information on the leatherback extinction crisis in the Pacific. Population Graphs and Articles The following three nesting beaches are among the most important in the Pacific. The long-term nesting data from these beaches serves as an index for leatherback population trends throughout the Pacific. * Graph of crashing populations throughout Mexico. * Graph of crashing populations on Costa Rica's most important nesting beaches. * Graph of crashing populations in Terengganu, Malaysia. In the 1950s this now-decimated population was hailed as the most important population worldwide. Article in Nature describing the leatherback population crash in the Pacific. Documents from the April 2002 Leatherback Survival Conference: The conference resolution was written and signed by a majority of the conference's participants, who represent widely varied stakeholder groups. Summary of top priorities as identified by the conference's three working groups. Quotes from Prominent Experts and Conference News Release: Quotes News Release on the Leatherback Survival Conference. Media advisory on the Leatherback Survival Conference. April 2002 Leatherback Survival Conference Information Conference Overview Bios for Leatherback Survival Conference participants (as available).


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Never having been a slave to fashion, I didn't expect to care much for "Valentino: The Last Emperor." I was delightfully mistaken. From beginning to end, it was a film feast for the eyes.
The man who dressed Audrey Hepburn, Jackie Kennedy and Princess Diana has been an icon of haute couture for more than 45 years. When asked at the onset of the film, "What do women want?" his simplistic, yet revealing reply was, "They want to be beautiful." And judging from this engaging documentary, Valentino
Garavani's manifest destiny was to make that desire a reality by designing astonishing garments. Garments that are meticulously all handmade. No sewing machines in sight in this film. Valentino takes perfection to new heights by creating gowns that are exquisite works of art.
This is all caught through the lens of special correspondent for Vanity Fair, Matt Tyrnauer. Shooting 250 hours of footage over two years, he has concocted a visual masterpiece. But, he also provides an exposé of the pivotal moment in Valentino's career when fashion went corporate.
The 50-year partnership between Valentino and Giancarlo Giammetti is the focal point from which Tyrnauer shoots this picture. Friend, lover and employee, Giammetti is the creative businessman responsible for the firm's financial success. It's extremely interesting watching the two interact and at times hilarious. In the back of a limo, Valentino asks Giammetti, "How did I do?" His reply: "A little too tan."
In the end, Giammetti orchestrates a three-day 45th anniversary tribute to Valentino, which culminates at the Temple of Venus in the Roman Forum. It is a celebration befitting an emperor, extravagant beyond words. As Valentino takes his last stroll down the runway, there are tears in his eyes while everyone applauds. I applaud this smart and discerning piece of filmmaking.
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The Church of the Redeemer celebrated its organist and choirmaster, Ann Stephenson-Moe, for her 40 years of service Saturday, Feb. 22. -
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