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Welcome to the Writing Center!
The Writing Center exists to serve Vanguard University's student writers across the curriculum on the undergraduate and graduate levels by providing informed reading and feedback as well as instruction for specific writing weaknesses. Committed to integrating faith and learning in a culturally diverse, Christ-centered collaborative environment, the Writing Center endeavors to assist students with improving their writing skills in concert with their critical command of content and rhetorical structure.
Writing Center consultants work with Vanguard students one-on-one at any stage in the writing process. Students should bring in writing projects they're creating, such as expository essays and researched writing. We help students organize notes, develop outlines, revise thesis statements, and work on various aspects of atomistic and holistic revision. Please click here for the Writing Center SLOs (Student Learning Outcomes.)
*New* Welcome Video!
Watch our 3-minute cartoon video welcoming Vanguard students to the Writing Center!
Please note: 21st Century writing centers are not proofreading or editing services. Using a hybrid balance of technology and face-to-face time, we empower writers who'd like to develop strengths in process-oriented revision. Guiding students through thoughtful revision supports long-term improvements in writing strategies and critical thinking skills. With regard to "grammar issues," for instance, we may point out flawed sentence patterns and provide relevant information so students may revise their own projects. We do not write papers for students, and we do not "correct." Verbs we like to use: develop, originate, analyze, explore, brainstorm, focus, strengthen, propose, assert, prove, contend, synthesize, draft, expand, and revise, revise, revise.Our Location
The Writing Center is located in Heath 214, on the 2nd Floor of Heath Academic Center.
Mondays through Thursdays, 9 a.m. to 5 p.m.
Fridays, 9 a.m. to 1 p.m.
Closed during Chapel Hours on Monday, Tuesday, & Wednesday.
Closed during University Holidays, including Thanksgiving Break & Christmas Break.
Face-to-Face Appointments
Schedule an appointment and come visit us!
You may call extension 4774 or make your appointment in person.
Please note: *Appointments are required.*
Due to the high volume of appointment requests, drop-ins are not guaranteed writing feedback.
Electronic Appointments ~ Traditional Undergraduates
Electronic appointments are designed for the convenience of commuting traditional undergraduate students. Please call extension 4774 or e-mail writingcenter [at] vanguard [dot] edu to request an appointment.
Please note: *Appointments are required.*
Please *do not* email a writing project without reserving an appointment first.
Papers emailed without appointments will be automatically placed on the Waiting List.
Please note: This service is available only to current traditional undergraduate Vanguard students who are commuters.
Graduate, SPS, and Summer Session On-Line Consultations
For Graduate, SPS, distance-learning, and Summer Session students, we provide on-line consultants who review writing projects on a first-come, first-served basis. Appointments are not required for this service. We aim for a 72-hour turnaround for all papers, so please plan accordingly. Please e-mail your writing projects as .doc or .docx attachments to gpswritingcenter [at] vanguard [dot] edu.
Please note: This service is available only to current Graduate, SPS, distance-learning, and Summer Session Vanguard students.
Writing Center Stamp
Vanguard students: If your professor requires a Writing Center Stamp as proof you received suggested revisions, please tell your Writing Consultant. At the end of your appointment, the Writing Consultant will stamp your paper. Some professors award extra credit for Writing Center stamps, while other professors require the stamp before accepting the final draft of your paper. If you are an on-line student whose professor requires a Writing Center Stamp, your Writing Consultant's e-mail message is equivalent to a stamp.
Writing Center Survey
You're welcome to fill out the Writing Center Survey. We look forward to your feedback!
Writing Center Referral Form — For Faculty
Faculty referring students for long-term usage are invited to complete the Writing Referral Form on our website. Please complete it & email it to us. Our consultants will set up a long-term progress log to assess writing improvement. This will enhance our annual assessment of the Writing Center's SLOs and assist you in tracking the student's writing development.
Writing across the Curriculum
What is writing across the curriculum? How are "writing to learn" and "writing in the disciplines" important parts of it?
- Rubrics & guidelines for writers in various disciplines, thanks to GMU.
- Compilation of articles & strategies, thanks to the Illinois College Writing Center.
- Faculty Resources at Vanguard University.
Our PowerPoint Presentations
Writing Center Orientation PPT (15 minutes)
Integrating Faith & Learning PPT (30 minutes)
Thesis Statements PPT (20 minutes)
Zapping the Bugaboos: Top Five Hit Parade PPT (30 minutes)
Introductions and Conclusions PPT (15 minutes)
Sentence Clarity and Variety PPT(15 minutes)
Critical Thinking & Writing PPT (20 minutes)
Logical Fallacies PPT (15 minutes)
Writing a Smooth Paper PPT (15 minutes)
Writing a Research Paper PPT (30 minutes)
Writing Handouts
Writing Handouts (includes academic citation styles)
*Please note: Since academic citation styles constantly evolve, it is important for students to practice the discipline of using citation manuals rather than "memorizing" styles. We guide students to use these resources, but we are not an editing or proofreading service.
Grammar Bugaboos
Grammar Bugaboo Check Sheet
Grammar Bugaboo Key
Bugaboo Bee Points (bookmark)
Writing Center Newsletter:
Rhema, The Living Word
The Writing Center newsletter, Rhema: The Living Word, features articles on composition theory and useful writing tips. Sample our newsletter articles from past, present, and future issues:
- Commonly Seen Errors in Students' Papers by Ryan Chapman
- Dialogue, Multiculturalism, and the Writing Classroom by Theresa White
- Apostrophe, Apostrophe! by Lance Trueb
- Computer Technology in the Writing Center by Allison Blackwell
- Holistic and Atomistic Revision by Colleen Warner
- Introductions and Conclusions by Bethany Schaefer
- Let Those Papers Shine! by Laurie Sowers
- Making Peace with Punctuation by Katie Keck
- Multimedia Presentations by Eric de Roulet
- Using Secondary Sources by Erica Marshall
- What to Expect from a Writing Center Appointment by Melissa Abel
- Writing a Purpose Statement by Dr. David G. Clark, Professor of New Testament & Greek
- Writing a Research Paper by Natalie Nadine Breeden
- Writing a Thesis Statement by Joann DeSmith
- Writing Center Philosophy by Hannah VanderBush
Campus Diversity Resources
Office of Diversity Programming & Mobilization
Diversity Scholarships
Affiliated Diversity Offices
Learning Resources
Writing Archive of Excellence
Student Resources
Rhema: The Living Word
VU Library
Learning Center
Career Center
Writing Center Usage
Writing Sessions Served
2012-13: 2,210 // Waiting List: 356
2011-12: 1,747 // Waiting List: 556
2010-11: 1,450 // Waiting List: 484
2009-10: 1,316 // Waiting List: 399
2008-09: 1,750 // Waiting List: 559
2007-08: 1,719 // Waiting List: 675
2006-07: 1,539 // Waiting List: 298
2005-06: 1,270 // Waiting List: 65
2004-05: 1,123 // Waiting List: 68
2003-04: 603
Global English
ESL Tip Sheet for 10 Languages (from Keys for Writers, Ann Raimes)
ESL Cyber Listening Lab
Additional ESL Resources
Writing in a Bilingual Classroom
English Language Space Station (A UK ESL site)
Professor Jill Savitt, English & Spanish (Yale-New Haven Teachers Institute)
Writing an In-Class Essay
Writing Center at the University of Washington
Writing a Scholarship Essay
Handout from the University of Colorado
Tips from Yale University
Handout from University of California, Irvine
Tips from International Students Dot Com
Career Development Center
Sample Cover Letter
Sample Curriculum Vitae
Writing a Graduate Application Essay
"The Graduate School Essay" by University of Massachusetts, Lowell
"Writing the Graduate School Application Essay" by the Dartmouth College Writing Center
Writing a Business Letter
Guidelines for Business Letters
"Faith and knowledge resting on the hope of eternal life . . ." (Titus 1:2).


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Find hotels in Saint Robert using the list and search tools below. Search for cheap and discounted hotel and motel rates in or near Saint Robert, MO for your business or personal leisure travel. Discover the most popular Saint Robert Missouri hotel rooms. Review the Saint Robert hotel list below to find the perfect lodging. We also have a map of the Saint Robert hotels. Booking 5+ Rooms? Find Saint Robert Group Hotel Rates The Saint Robert center is approximately 5 miles from Waynesville Regional Airport At Forney Field and 21 miles from Phelps County Regional Medical. |
Saint Robert Hotels/Accommodations
Next 20 Saint Robert Hotels > [1 - 20 of 50] Next: See My Saint Robert Hotels with Pricing > |

subset: commoncrawl


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New Animal Study Might Explain Jet Lag Differences
Traveling west to east? Blame your brain for the added disruption
FRIDAY, Oct. 21 (HealthDay News) -- The way the human circadian clock sets itself may explain why jet lag tends to affect people more severely when they're flying west to east compared to the other direction, a new animal study indicates.
The circadian clock, which regulates many body processes, has to make regular adjustments to stay synchronized with the light-dark cycle of where a person is and does this by delaying or advancing its time in response to light.
Typically, these adjustments occur without notice. However, the process is disrupted by sudden major changes in the light-dark cycle, such as when a person takes a long flight.
Previous research found that delaying and advancing the circadian clock occur in different pathways in an area of the brain called the suprachiasmatic nucleus. This new study found that the molecular mechanisms in these pathways are significantly different.
"We have known for decades that, in humans and other organisms, advances are always much harder to achieve than delays. For example, compare jet lag going to Europe with that coming back," Horacio de la Iglesia, an associate professor of biology at the University of Washington, said in a university news release.
"One of the reasons may be that these two forms of resetting the clock involve different molecular mechanisms at the clock level," he suggested.
The findings from experiments with hamsters could help in efforts to develop remedies to jet lag, according to the researchers.
The study was published online recently in the Proceedings of the National Academy of Sciences.
More information
The U.S. Centers for Disease Control and Prevention has more about jet lag.
Robert Preidt SOURCE: University of Washington, news release, October 2011 Related Articles- Sleep Disrupted? Maybe It's Daylight Saving Time
March 10, 2014 - Just 1.5 Hours of TV a Day May Disrupt Kids' Sleep, Study Says
March 10, 2014
Learn More About Sharp
Sharp HealthCare is San Diego's health care leader with seven hospitals, two medical groups and a health plan. Learn more about our San Diego hospitals, choose a Sharp-affiliated San Diego doctor or browse our comprehensive medical services.
Copyright © 2011 HealthDay. All rights reserved.


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Health Insurance Exchange Rates Surprisingly Low
"I think that's what we're going to see across the country," said Robert Zirkelbach, spokesman for America's Health Insurance Plans, in a statement. "Competition is a good thing."
States are also planning to pour millions of dollars into public outreach programs to market their exchanges. California plans to spend nearly $200 million on its marketing campaign and deliver ads in more than a dozen languages.
Keeping it Simple
One of the key concerns heading into 2014 is that the process of buying insurance online will be tedious and frustrating for potential applicants. That became an even bigger concern in early 2013 when the federal government issued a draft application form for enrollees that was 23 pages long.
The Centers for Medicare & Medicaid Services has since reconsidered that form, releasing a streamlined version in May that is just three pages long.
"Consumers will have a simple, easy-to-understand way to apply for health coverage later this year," said CMS Administrator Marilyn Tavenner in a statement. "The application for individuals is now three pages, making it easier to use and significantly shorter than industry standards. This is another step as we get ready for a consumer-friendly marketplace that will be open for business later this year."
There's also a concern about whether the federal government will be able to organize and build a central exchange to serve the states that opted not to create their own exchange. But officials say that project is on schedule.
Comments are moderated. Please be patient.
Raye (7/20/2013 at 3:20 PM)
They ask for annual income, is this gross, net or adjusted?
Tyco Brahe (7/19/2013 at 11:03 AM)
Insurance companies tried to keep prices down in the past by selling insurance planes with many holes in them [INVALID]lifetime caps, the ability to cancel the plan at will, limited coverage, etc. Obamacare gets rids of all those holes (because once you fell into a hole, the government would have to pick up much of the tab). So, it's understandable that, at first, prices may go up mildly. However, as more and more people now have to buy insurance and will have access to primary care providers (instead of relying on the ER when diseases get really bad), prices should come down.
- Hospital Groups Strike Back at Hospital Rating Systems
- Two-Midnight Rule Must be Fixed or Replaced, Say Providers
- The Secret to Physician Engagement? It's Not Better Pay
- AHIP: Enormity of HIX Challenges Sinks In
- Don't Underestimate Emotional Intelligence
- 4 Reasons PCMH Principles Aren't Going Away
- Yale New Haven Health Partners with Tenet Healthcare in CT
- Evidence-Based Practice and Nursing Research: Avoiding Confusion
- Care Coordination Tough to Define, Measure
- How Succession Planning Boosts Employee Retention Rates


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Yves Saint Laurent • Le Rouge • Lipstick
(3 reviews)
Average Rating. | 4.3 |
Would buy this product again. | 66% |
Ingredients |
Top Rated Lipstick
MAC Up The Amp
216 reviewsMAC Pro Lipstick - Show Orchid
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70 reviews
rockstar00 on 1/4/2013 12:35:00 PM more reviews by rockstar00
Age: Unknown Skin: Combination, Olive Hair: Brunette, Fine Eyes: Brown
Le Rouge by YSL is my first YSL lipstick purchase. I own one YSL glossy stain that I adore so I figured I would try out the lipstick.
I am a red, hot pink, magenta to fuchsia lipstick wearer so bold lips are in my comfort zone.
Le Rouge is a Blood Red color.
-packaging is stellar.
-color is a bright red with some blue but not too much.
-pigmentation is rich
-product is moisturizing
-good couple of hours wear (drinking and some snacking included)
-I have also been asked 133431421241234 times which lipstick color I'm wearing by chicks when I rock Le Rouge. Cool guys just say "I like your lipstick" : )
I simply love everything about this lipstick. I plan on purchasing Le Fuchsia.
I picked this bad boy up at Sephora in Las Vegas it was the last in the store. It is always sold out on Sephora.com.
Was this review helpful to you? Yes No
*TOP REVIEWER* ltgee on 4/6/2012 5:19:00 PM more reviews by ltgee
Age: 36-43 Skin: Oily, Tan, Warm Hair: Brunette, Straight, Fine Eyes: Brown
ROUGE PUR COUTURE SPF15 - Pure Colour Satiny Radiance in #1 Le Rouge-Blood Red:
This is a TRUE red, doesnt pull orange or berry. That said, it made me look pretty flat. I opted for this brand but in #20 Rouge Flamme-Cranberry Red. I was looking for a true red but you know, sometimes the true red won't look that great on you! the berry in the #20 gave my face some LIFE and it was more modern. i looked so dated with the true red on. i have pigmented lips, warm yellow toned southeast asian skin. #20 is a gorgeous red! texture was very moisturizing though and great color payoff. used my 15% chic coupon so score!
Was this review helpful to you? Yes No
*TOP REVIEWER* sweetgardenangel on 11/9/2010 7:54:00 AM more reviews by sweetgardenangel
Age: 44-55 Skin: Combination, Fair Hair: Blond Eyes: Blue
The new Rouge Pur Couture called "Le Rouge" is absolutely a true bright red! Can't distinguish bluish tones or warm, or whatever, I can only see what I see and that's a true red if you are searching for "the one."
It's marvelous at moisturizing, it's long-wearing without changing color, and it's slightly shiny in a satin texture.
This was my first YSL lippie. The next one will be in the nude or pink category but that will be in the future as this one will set you back $30.
If you plan to wear anything in the bright red category, then you need this one to finish the look! I find that my choice of lipcolor has to be complimentary to the outfit I'm wearing.


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Orgran Gluten Free Rice & Corn Vegetables Pasta Animal Shapes 200g
Product Description
Gluten, wheat, dairy, egg, yeast, GMO, soy & nut free
Suitable for vegetarians & vegans
Kosher - Parve
Farm animals rice & corn vegetable pasta
Orgran Rice & Corn Vegetable Pasta is a quality product produced from a natural blend of Rice, sunripened Corn and Vegetables. It is naturally wheat free, gluten free and provides energy, nutrition and variation essential for a well balanced diet and well being.
Orgran Rice & Corn pasta has diverse nutrition to wheat pasta and being gluten free also offers greater digestibility which is generally better suited to growing children. The Orgran production plant is also one of the few plants in the world specifically designed and producing in a strictly controlled, totally wheat free, gluten free environment to ensure highest quality and purity of natural foods. The very unique processes encompasses traditional methods to retain the delicate natural flavour of the grains and also ensures the product offers the highest biological benefits to meet the strictest demands set by consumers of natural foods and those on specialised diets.
Enjoyed around the world Orgran is a leader and trusted name in natural nutrition and foods for well being. You can be safe in the knowledge that no artificial colours, flavours or preservatives have been added to this product.
Orgran: Leading gluten free natural foods.
The trusted name in natural nutrition and foods for well being.
A gluten free food should not be a compromise alternative but a natural way to fulfilling dietary requirements. The food needs to be pure in ingredients and production and free from potential allergens. It should also be of natural composition and should have adequate nutritional value to promote and regenerate better health and dietary balance.
Orgran is the pioneer producer of natural gluten free foods and specifically utilises wholesome natural alternative grain nutrition to assist fulfill dietary requirements for optimum digestive health and well being.
More than 70 natural products. Available in 50 countries.
For a natural treat try Orgran OutBack Animals Chocolate Cookies
Please visit our website and discover the benefits of Orgran natural foods.
Servings per pack: 5
Made from local and imported materials
Allergen Free International (A.F.I.)
Please Recycle
Product Information
- Speciality / Free From / Dairy Free / Pasta & Noodles / Pasta
- Speciality / Free From / Egg Free / Pasta & Noodles / Pasta
- Speciality / Free From / Soya Free / Pasta
- Speciality / Free From / Nut Free / Pasta
- Speciality / Free From / Gluten Free / Pasta
- Food Cupboard / Rice, Pasta, Noodles & Pulses / Pasta / Gluten Free Pasta
- Food Cupboard / Rice, Pasta, Noodles & Pulses / Pasta / Kids' Pasta Shapes
- Speciality / Free From / Gluten Free / Kids
- Speciality / Free From / Wheat Free / Pasta & Noodles / Pasta
- Speciality / Free From / Lactose Free / Pasta
- Speciality / Free From / Yeast Free / Pasta
- Brands: Orgran
- Dietary & Lifestyle: Gluten Free, Egg Free, Nut Free, Vegetarian, Yeast Free, Wheat Free, Kosher
Prepare & Use
You can be safe in the knowledge that no artificial colours, flavours or preservatives have been added to this product
Hob - From Ambient
3 Easy Steps
Step 1
Place contents into plenty of boiling water (approx 2 litres/ 70 fl.oz for every 100g/3.5oz. of Orgran pasta). Salt may be added to the water.
Step 2
Stir gently and continue to boil for 8-10 minutes or until preferred consistency.
Step 3
Strain and rinse under warm running water.
Country of Origin
Orgran (UK),
Micross Brent Terrace,
Package Type
Recycling Information
Allergen Information
- Free from: Nut, Gluten, Wheat, Egg, Soya, Yeast
Rice 86%, Maize Meal 8.3%, (Spinach, Beetroot) 5.7%, Water Added.
Dietary Information
Suitable for Vegans
Suitable for Vegetarians
Free From Gluten
Free From Wheat
Free From Eggs
Free From Dairy
Free From Nuts
Free From Soya\Soybeans
Free From Yeast
Free From Genetically Modified Ingredients
Nutritional Data
Typical Values | per 100g | Per Serving 40g |
Energy | 1390kj | 556kj |
Energy | 329kcal | 131kcal |
Protein | 9g | 3.6g |
Carbohydrate | 76.9g | 30.7g |
of which sugars | 0.8g | 0.3g |
of which starch | 76.1g | 30.4g |
Fat | 0.6g | 0.2g |
of which saturates | 0g | 0g |
Fibre | 2.8g | 1.1g |
Sodium | 0.01g | <0.01g |
- Life guarantee
- * Minimum life based on 'use-by' date of product. Average life based on last week's deliveries. Life guarantee shown based on delivery tomorrow and includes day of delivery. Please book a slot to view Life guarantee for your chosen delivery day. See Terms and Conditions for further details.
- Disclaimer
- These summary details have been prepared for information purposes only, and are designed to enhance your shopping experience on the Ocado website. While we have taken care in preparing this summary and believe it is accurate, it is not a substitute for your reading the product packaging and label prior to use. You should note that products and their ingredients are subject to change. If you do require precise ingredient information you should consult the manufacturer, whose contact details will appear on the packaging or label.
- Ocado is therefore unable to accept liability for any incorrect information. Where this description contains a link to another party's website for further information on the product, please note that Ocado has no control over and no liability for the contents of that website.
- You should also note that the picture images show only our serving suggestions of how to prepare your food - all table accessories and additional items and/or ingredients pictured with the product you are purchasing are not included.
- This data is supplied for personal use only. It may not be reproduced in any way whatsoever without Ocado Limited's prior consent, nor without due acknowledgement.


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My son, infant and myself walked out of Petland tonight at about 10 til 9 and saw a car with flames shooting out of the crushed hood. Wow! We watched as the firemen put out the fire I just happened to be able to snap a picture just after the flames were put out.
Car Fire in Iowa City
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Town Square
Tonight: Menlo Park studies housing
Original post made on May 8, 2012
Read the full story here Web Link posted Tuesday, May 8, 2012, 8:55 AM
Comments (3)
on May 8, 2012 at 6:58 pm
Having lived here since 1973, we have seen some incredible fiascos brought forward to be VOTED ON by the residents, despite the fact that the proposals are not relative to the General Plan, which is supposed to be followed, by STAFF, Commissions, Councils , and the city attorney. In the 70's the primary staff management were residents. They were responsible for listening to the residents. The current staff is only paying attention to ABAG CCAG, and the PLANNERS in Sacramento , who have no reason tp follow our General Plan and they have found many "methods " to force this town and others on the peninsula into a budding disaster.....Our managment staff does not live here, and ignore the residents....MP government has become quite transparent, i.e........The real estate "groups are calling the "shots....We do not have city councils that have a backbone, or guts enough to tell the staff nor Sacramento to SHUT UP......,OUR COUNCILs are elected to represent the
residents not the BIG EGOS here and in SACRAMENTO.. I have noticd that many towns ignore Sacramento, etc..such as Hillsborough, Portola Valley, Woodside, Los Altos, Los Altos Hills,& Atherton .....those are just around here....There are others thruout Calif....Tis time to wake up, neighbors, before you lose your community to the BIG EGOS.
on May 9, 2012 at 8:49 am
There is a huge difference between the towns Don mentions and the CIty of Menlo Park. None of those towns has or wants any significant commercial enterprizes within their borders. Instead, they rely on revenue from other sources than sales tax to fund their town budgets, such as property tax and parcel taxes. Menlo Park has a significant commercial economy, more so now with FB, and relies on that economy to deliver the revenue to cover city services. A completely different model. The State has the authority and mechanisms to bring pressure on cities to address any jobs/housing imbalances or lack of affordable housing. It would be short sighted and detrimental if the leadership (elected and staff) of the city did not address the housing element issue.
on May 10, 2012 at 12:25 pm
Property taxes can't grow much because of prop 13. Menlo Park has no long term fiscal plan or disclipline.
A big problem is that Menlo Park's councils keep approving major projects that add more jobs but not housing. Recent huge projects like Menlo Gateway's nearly 1 million square feet of office and the downtown plan, and even Facebook, don't produce business sales tax revenue. The downtown plan doesn't require any housing. So Menlo Park continues on the path to have more pressure for housing and fewer sources of revenue.
If you were a member and logged in you could track comments from this story.
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Savory Garlic Green Beans Recipe
This savory side dish is a wonderful accompaniment to pork, beef and poultry. In season, fresh garden green beans can be substituted for the frozen.
- 1/2 cup water
- 1/2 teaspoon chicken bouillon granules, optional
- 1 package (16 ounces) frozen whole green beans
- 1 to 2 garlic cloves, minced
- 1 tablespoon butter
- 1/4 teaspoon seasoned salt
- In a saucepan, bring water and bouillon if desired to a boil. Add beans. Reduce heat; cover and simmer for 10-12 minutes or until beans are tender. In a large skillet, saute garlic in butter for 1 minute. Drain beans; add to skillet. Sprinkle with seasoned salt and toss to coat. Yield: 4 servings.
Originally published as Garlic Green Beans in Taste of Home Meals in Minutes Calendar
Annual 2002, p9
Reviews for Savory Garlic Green Beans(2)
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Bill McKibben and 350.org on the 'Do the Math' Tour
A 21-city tour to demonstrate the simple numbers that add up to global catastropheLATEST PHOTOS
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A Most Important Fight
"We started the night after the election – which was a message in itself – but also a bit of a bummer. After a nice handful of wins, it's tough to spend a few weeks reminding our friends about how we are still losing quite badly in this most important of fights." –B.M.
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on the
Wednesday, September 5, 2012
The second night of MTA New York City Transit's ambitious maintenance effort —FASTRACK— continued last night and early Wednesday morning along the Lexington Avenue Line between Grand Central-42 St and Atlantic Av-Barclays Ctr, Brooklyn. FASTRACK entails the partial closure of a subway line to train service on consecutive weeknights and for seven continuous hours (10 p.m. to 5 a.m.). This round of FASTRACK on the lines runs through 5:00 a.m. Thursday, September 6. Because no trains are running along a designated area of a subway line, maintenance crews can work on and near the tracks without having to stop work every few minutes while a train moves through the area. This is safer environment for employees and a more efficient way to maintain and clean New York City's massive underground transportation system that runs around the clock.
With no trains running along Lexington Avenue, more than 800 Transit employees were able to inspect and repair signals and switches, repair and replace track rails and cross ties, and scrape track floors, resulting in the removal of dirt and debris, Workers were also able to perform escalator and elevator maintenance, repair water damage, clear drains and clean stations. In subway stations, paintable areas not reachable during normal train operation were scraped, primed and painted. Crews also took the opportunity to clean lighting fixtures, change bulbs and repair platform edges while performing high-intensity station cleaning. These maintenance activities improve train performance and efficiency while also providing a pleasant station environment.
Major accomplishments from last night's maintenance effort include repairing a leaking air line for a track switch, servicing two switches and 13 gap fillers (movable platform extensions where the curvature of the platform creates a significant gap between the platform and subway car door). The night's work also included removing 1,310 bags of debris, resulting in the removal of 42,250 pounds of scrap and debris. With an eye toward keeping the tracks and third rail in good condition, workers installed 251 track tie plates, 55 track tie blocks, corrected 348 third rail defects, and cleaned, scraped, and bagged 1,655 linear feet of debris under and around the third rail. In addition, maintenance crews installed 75 linear feet of handrail, repaired 25 leaks, cleaned the bench wall (elevated walkway along the side of tunnels used by maintenance crews) and continued cleaning track drains. Also, with employee safety in mind, workers installed 150 linear feet and cleaned 1,000 linear feet of "no clearance signs."
For a more aesthetically-pleasing and safer subway station environment, 4,050 square feet of paintable surface was scraped, 1,100 square feet was primed and painted and 20 square feet of concrete platform surface was repaired. At Bleecker St and Spring St stations, crews replaced monitors that are part of the stations' Closed Circuit Television system (CCTV) and the systems at both locations and at Astor Pl station were optimized for clarity. To keep elevators up and running, maintenance was performed on three machines on the Lexington Avenue line.
How this impacts service?
Reliable service - service you can depend on to get you to where you need to go when you need to get there - requires regularly scheduled maintenance to critical components you never see. Pumps, signals, track, and power are just some of the vital system equipment we are focusing on so that we can continue providing our riders with train service that is safe and reliable.
- Google Translate


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My char: http://eu.battle.net/d3/en/profile/HOLYSHADOW-2943/hero/1195323
You have to abandon offensive spell and buff, use a single armor that suite your gear (mine primastic due low resistance) and work on passive damage increase bonus: 20% chill, 20% slow time, 15% frost nova.
Use this simulator to understand how much DPS you can do with buffes. Having LoH or similar increase survival ALOT but it's not mandatory, as I said mobs won't even touch you.
- 3/2/2013 9:43:58 AM posted a message on Posted in: Wizard: The Ancient Repositories
posted a message on Never used LoH or Life steal, just blood magic as archon. I actually play mp8 flawlessy as CM/WW with poor ehp, just hit 2,74 attack speed and 42-50% crit: mobs won't even touch you, while all the other damage (pools, arcane lazors etc) are absorbed by Diamond skin.Posted in: Wizard: The Ancient Repositories
Go for Chantodo with socket and average Int. -
posted a message on People still search some kind of ruolistic pvp everywhere, meanwhile OSI servers are still online. All the true pvp players should go back there, the others asking for two-buttons pvp (?) on a hack-n-slash.. well, I just say LOL. Whatever Blizz will introduce must be taken as a side event, nothing more/less than an Infernal Machine bullshit to fullfill patches.Posted in: PvP Discussion
The (marketing) CORE of Diablo it's and it will perma-be the ITEM FARMING. Nothing else.
And now get all back to your mindless monster melting. -
posted a message on Didn't know about movment speed cap sorryPosted in: Wizard: The Ancient Repositories
posted a message on Andariel visage slow your exp but hugely increase your killing spree in Archon, apart that you just need a black weapon with crit (socket?) and a cheap triumvirato. Next level it's with Lacuni (36% movment speed LOL) but with crit chance are quite expensive.Posted in: Wizard: The Ancient Repositories
That's all, you're already highly geared for mp1-2, some improvments can make you perma-Archon mp4. -
posted a message on Absolutely Alkaizer route. This dude made an awesome Archon budget wizard and related video with the route. I'm doing it on mp3 quite easy (with better gear, obviously) and I'm considering to nerf dps, go mp2 and use head socket + infernal machine ring. The exp rate is amazing, seriously.Posted in: Diablo III General Discussion
Must say that I keep swapping missions, I used to farm Act III (like everyone) pre 1.0.5 so I'm really tired by it. But works.
http://www.youtube.com/watch?v=23mxZR5AToY -
posted a message on Yeah a week ago I started a mp2 act II key run and the first kill was a goblin, wich dropped orange, then the first elite pack, second and third, 4 legendaries in a row, I ended 50-60 mins after with a total of 9 drops. I usually get 1 legendary per day or two.Posted in: Diablo III General Discussion
posted a message on You lack of critical damage, try to change your gloves with a combo crit and crit damage (if trifecta with ias is better). 30-35% of critical damage on gloves will bump you at least of 15k dps. Also the tal rasha bonuses are fine, but the belt is quite horrible and the BiS belt for every wizard is the Witching hour (wich has critical damage and ias).Posted in: Wizard: The Ancient Repositories
A huge increase will come swapping the chest with tal rasha (so you can change the belt and keep the bonus) and keep the zunimassa bonus with Zunimass boots (wich are BiS aswell).
As you can see my toon has probably worst gear than your, but I managed to get 132k dps and I only have 230% critical damage. A proper weapon/amulet/belt would increase dps at least another 30-40k.
- Change gloves, ASAP
- Get Tal rasha chest
- Get Zunimassa boots
- Get some bracers with better stats
Remember, INT has priority, every 10 stat point you'll gain 1 to All res. Reaching 3000 int is a solid 300 to all res and a huge dps increase. Don't understimate also the power of Add % life affix.
edit: (I guess people already said that your Vile guard is rolled for barbs and not wizards :D) -
posted a message on Well I remember the first patches, after release, when Inferno was Inferno and nobody was beating it with the same build. Nowdays you're forced to CM and almost perfect rolled BiS items to reach MP10 wich yes, isn't that important, but still reachable in 1-2 ways for a wizard. Design limitation in my opinion. It's the same of all theyr games: instead of fixing theyr errors replacing with new things, they just nerf the current till the "doable" level.Posted in: Wizard: The Ancient Repositories
Why we're forced to Archon-CM build to reach mp10, even if it's worthless? I don't think it's the same for other classes.. I hope. When D3 was released I was very happy by the skill system, hundreds of choices and builds, similar to vanilla/tbc wow.
Maybe I'm just tired of the same class, never played anything other on D3 apart wizzy
Edit: With my gear and build farming on mp3-4 or even mp5 is really fast and worth the time, considering drops and exp, I made the thread looking for suggestions on builds, wasn't believing CM and Archon were the only way to progress on 1.0.5 -
posted a message on That build is very intere sting, but without LoH and some solid all resistance I die too often, plus I feel so nerfed not being able to derpTeleport here and therePosted in: Wizard: The Ancient Repositories
My build is not pure Archon but as I said mp2-3 it's very easy and fast, apart damage reflect wich mean 3-4 deaths before the pack fall.
Maybe re-rolling Shaman and swapping the gear - as many people did - is the best solution right now. Otherwise I'm forced to look for APoC gear and go CM wich I really hate..
Well, thanks for the tips anyway. At least now I really know how this class has been destroyed. - To post a comment, please login or register a new account.


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(2012)Chris Harrison on Bachelor Juan Pablo Galavis: "From the Beginning Something Just Didn't Seem Right"
Chris Harrison has opened up about Juan Pablo Galavis following the Bachelor's extreme backlash and catastrophic Season 18 season finale: "From the beginning something just didn't seem right"
Us Weekly2-Year-Old Suspended from Daycare Over Cheese Sandwich
According to The Huffington Post, Randy Murray gave his two-year-old a cheese sandwich to eat before leaving for her daycare.
ParentingPolice: 3 who attacked couple went to wrong home
MADISON, Wis. (AP) — The men accused of severely beating a man and repeatedly sexually assaulting his pregnant wife may have meant to target a different home for a robbery, authorities in Wisconsin said.
Associated PressBobbi Kristina Defends Slender Frame
Bobbi Kristina Brown defended her slim frame after she was criticized for being too skinny, saying she takes after her mother Whitney Houston. "I am my mothers child ! Have you ever heard of a #fastmetabolism ?" Brown wrote on Twitter. "Lol, it's incredible how...
ABC News8 Baby Names Riding the Next Wave of Cool
I can't even tell you how many baby names I have scribbled on pieces of paper, how many lists I've compiled since before I ever even decided to start a family, how many texts I've sent to my dear friend, who also happens to be a baby name expert for Early Mama. I mean, already aviators are dated.
ParentingKim Kardashian Squeezes Into Kylie Jenner's Bikini
Kim Kardashian snatched up Kylie Jenner's two-piece in Miami on Wednesday, and shared a photo of herself wearing the tiny two-piece on Instagram.
Yahoo CelebrityThe ABCs of Oil Pulling: What is it and Should You Try It?
It's said that oil pulling can do everything from whiten teeth to cure eczema. "People swear by it - that it can fill cavities, relieve toothaches, whiten teeth, freshen breath, absorb harmful bacteria, and cure the common cold," said Dr. Jessica Emery, DMD of Sugar Fix Dental Loft Chicago.
Healthy Living'Little People, Big World' Stars Matt and Amy Roloff Separate
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Good Morning AmericaExpert: Girl's blood on over 30 items of evidence
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ABC NewsHouse backs bill to sue president over laws
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Associated PressReport: NSA Pretends to Be Facebook in Surveillance
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Información de escena
Sleaze : Vin Nolan, Marc Williams, Derrick Hanson
- Puesto al dia : 2007-08-01 |
- Longitud : 16:50 min |
- Tamaño : 184 MB |
- Imágenes : 10 |
- Vistas : 3204 |
Rating : 8 out of 10
Sleazy-hung-pimp Vin Nolan summons his gang of Derrick Hanson and Marc Williams to satisfy his sleazy urges. The three take turns on each of their well hung cocks. Upon inspection Hanson is jerked and worked in both his hungry holes with Nolan and Williams doing an excellent job of opening him up bouncing from one hard-on to the other until all three shoot great amounts of cum onto Hanson.
Recommended Scenes
Hot Pursuit : Brett Ford, Tony Belmonte, Michael Steel, Jason Andrews, Joe Romero, Chuck Hunter
Actualizada el: 07-01-2010


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Overview of articles in Ariadne
This page provides access to brief summaries of 1735 articles in Ariadne, listed in reverse chronological order. In tab below you can adjust filters to display sub-sets of articles (see FAQs on filtering for usage tips). Select this link to remove all filters.
Note: See our citations page for examples of the bibliographic format.
Article title | Summary | Date published |
Book Review: Super Searchers Make It on Their Own |
Lina Coelho looks at the work and lives of independent information professionals prepared to share their secrets for starting and running a research business. |
January 2004 |
Book Review: Supporting Research Students |
Brian Whalley reviews a work which helps Library and Information Science Staff at Higher Education Institutions to support their research students. |
April 2010 |
Book Review: Teach Beyond Your Reach |
Lina Coelho looks at this Instructor's guide to developing and running successful distance learning classes, workshops, training sessions and more. |
October 2006 |
Book Review: Teaching Web Search Skills |
Verity Brack takes a look at this book for Web trainers, teachers and instructors. |
April 2007 |
Book Review: The Academic Library |
Ruth Jenkins wishes this textbook had been available when she was a library school student. |
July 2005 |
Book Review: The Accidental Systems Librarian |
Eric Jukes takes a look at the strengths and weaknesses of another book in the 'Accidental' series. |
October 2003 |
Book Review: The Accidental Taxonomist |
Emma Tonkin takes a look at a book on the work of the taxonomist and notes both merits and disappointments. |
October 2010 |
Book Review: The Accidental Webmaster |
Andy Prue examines a guide aimed at inexperienced Webmasters. While the book covers some interesting and salient points, Andy raises questions as to the ideal audience. |
April 2004 |
Book Review: The Art of Community - Building the New Age of Participation |
Ed Bremner reviews a work on building and supporting online communities. |
July 2010 |
Book Review: The Cambridge History of Libraries in Britain and Ireland |
Lorcan Dempsey reviews Volume III of a landmark collection on the history of libraries in 'Britain and Ireland' from 1850 to 2000. |
October 2007 |
Book Review: The Cult of the Amateur |
Stephanie Taylor tries to curb her enthusiasm for Web 2.0 by investigating the dark side of social networking. |
October 2007 |
Book Review: The E-copyright Handbook |
Charles Oppenheim takes a look at the latest of Paul Pedley's copyright guidance books, and, in some respects, finds it wanting. |
November 2012 |
Book Review: The Embedded Librarian |
John Azzolini reviews a comprehensive overview of embedded librarianship, a new model of library service that promises to enhance the strategic value of contemporary knowledge work. |
November 2012 |
Book Review: The Expert Library |
Sylvie Lafortune reviews a book taking a hard look at academic libraries, how they are being redefined and what skills will be required of the staff who will move them forward. |
July 2011 |
Book Review: The Future of Archives and Recordkeeping |
John Azzolini reviews an anthology of perceptive essays on the challenges presented to archival thought and practice by Web 2.0, postmodern perspectives, and cross-disciplinary interchanges. |
March 2012 |
Book Review: The History and Heritage of Scientific and Technological Information Systems |
Charles Oppenheim takes a look at this series of personal and researched historical analyses of the history of computerised information retrieval systems, and finds it makes fascinating reading if you are interested in such things. |
February 2006 |
Book Review: The Information Professional's Guide to Career Development Online |
A book review by Pete Dowdell. |
April 2002 |
Book Review: The Information Society - A Study of Continuity and Change |
Lise Foster finds this a useful scene setter for the novice and valuable reminder for the professional of the challenges facing today's librarian. |
October 2004 |
Book Review: The Information Society - A Study of Continuity and Change |
Muhammad Rafiq offers us a detailed review of a work, now in its sixth edition, which examines the information society, its origin, development, its associated issues and the current landscape. |
July 2013 |
Book Review: The Institutional Repository |
Sally Rumsey recommends a new book about institutional repositories. |
April 2006 |


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Lesbian, Gay, Bisexual and Transgender Health
- GLMA Conference in Atlanta
- LGB Youth - New Report Reveals Disparities in Health Risks
- HIV and Transgender People
People who are lesbian, gay, bisexual, or transgender (LGBT) are members of every community. They are diverse, come from all walks of life, and include people of all races and ethnicities, all ages, all socioeconomic statuses, and from all parts of the country. The perspectives and needs of LGBT people should be routinely considered in public health efforts to improve the overall health of every person and eliminate health disparities. Read more
LGBT Health Topics
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Resilience in HIV-Affected Communities
Dr. Kevin Fenton reflects on the resilience of communities across the United States affected by HIV.
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Data and Statistics
Men who have sex with men (MSM) accounted for 63% of the estimated new HIV infections in 2010. Go to the HIV Incidence topic page for more information.
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1600 Clifton Rd
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TTY: (888) 232-6348 - Contact CDC–INFO


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Statement From A.G. Schneiderman On The Passing Of Assistant Attorney General Richard Schwartz
NEW YORK- Attorney General Eric T. Schneiderman today released the following statement in response to the passing of Assistant Attorney General Richard Schwartz.
"I send my deepest condolences to the family and friends of Assistant Attorney General Richard Schwartz who was tragically killed last night as a result of the storm. For over 25 years, Richard served the people of New York State with integrity as an expert antitrust lawyer in the Office of the Attorney General's economic justice division. New York is a better place because of Richard's commitment to fairness and legal excellence. Richard's loved ones are in our thoughts and prayers as we mourn the untimely loss of one of our own."


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Men's DI-AA College Top 25, March 19, 2012 |
Rankings - Men DI College |
After a week hiatus, the DI-AA rankings return with a lot of movement, as ranked conference rivals and out-of-league foes butted heads the last couple of weeks. The biggest non-conference meeting was between St. Bonaventure and Bowling Green. The Bonnies could still earn an automatic bid to the Sweet 16 by beating Iona in the Empire Conference championship match April 14, but Bowling Green, which finished second in the Mideast, needed a win to bolster its at-large resume. St. Bonaventure won 24-13, possibly taking away a second seed from the Mideast. In our rankings, all of the Mideast's teams fall, staying in their respective order. The big conference matches featured Florida and LSU, Maryland and Clemson/Virginia Tech and Florida State and Central Florida. Florida, Maryland and UCF all won those games, so they either jump, or stay, in front of the teams they beat. The Terrapins' wins make Maryland the odds-on favorite to win the Atlantic Coast, Florida's victory guarantees the Gators a rematch with LSU in the Southeastern semis, and the win over the Seminoles gives the Golden Knights a spot in the South Independent's semifinals. In Northern California, Sacramento State and Santa Clara have improved to 4-1, while Stanford and Chico have dropped to 1-4. So the Broncos and Hornets move up, while the Cardinal and Chico drop from the list. Arkansas rejoins the Top 25 after back-to-back wins in the Heart of America. The only reason they dropped was a narrow loss to Missouri. The Tigers have jumped up the list by beating the Razorbacks and Kansas in back-to-back big league games. Mizzou fell to DII juggernaut Lindenwood, but the fully varsity Lions are ranked second in DII and would most likely be a top-10 team in DI. 1 (1) Davenport 7-0 Was beating Grand Rapids when game was canceled for lightning Dropped out: |


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Recipes : Recipe Detail |
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- Source: Cooking Section, March 2002
- Dish Type: Sandwiches
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Chicken Sandwiches
Spread 1 teaspoon of mayonnaise on each slice of bread. Place 1 ounce of chicken in each sandwich. Season with salt and pepper. Trim off the crusts and cut the sandwiches into triangles or three strips, and cover with plastic wrap or a clean cloth as you work.
Makes 8 sandwiches
- 8 ounces skinless chicken breast, sliced and cooked
- 16 teaspoons mayonnaise
- Salt and freshly ground black pepper to taste
- 16 slices extra-thin wheat bread


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LAKEWOOD RANCH — Coastal Orthopedics & Pain Management took a major step east as it celebrated the grand opening of its new East Surgery Center April 16 in Lakewood Ranch.
The new 10,000-square-foot center will offer outpatient options for pain management patients beginning in mid-May and orthopedic patients by July, said Coastal Marketing and Community Relations Manager Sara Gaines.
With facilities at Point West Medical Plaza in west Bradenton, Lakewood Ranch Medical Center, Axcess Diagnostics on State Road 64 and satellite offices in Sarasota and Sun City Center, Coastal treats patients from Tampa to south Sarasota. Currently, Coastal conducts all its outpatient surgical procedures at its Point West location, but with its proximity to Interstate 75, officials expect the new Ranch location to become Coastal's primary outpatient surgery center.
"Our other surgery center is all the way out in (west) Bradenton," said Dr. Greg Farino, president of Coastals surgery centers and orthopedic surgeon. "We've wanted to do something out here for a long time."
Zirkelbach Construction completed the build-out of the new center in about six-and-one-half months, outfitting it with the latest medical technology and amenities — such as wide hallways and electric doors — Coastal's Point West Medical Plaza's facility lacks. The facility also features separate entry and exit doors, large, open pre-op and post-op wards and state-of-the-art operating rooms.
And unlike the Point West center, the East Surgery Center has room to grow, said Coastal Administrator Cindy Brennan, who worked with Zirkelbach on the center's design and even selected its wall colors and office furniture.
Ten surgeons, five physicians and one podiatrist — some from Coastal's other offices — will provide medical care at the new center, which also will create about 30 new staffing positions, Gaines said.
Contact Michael Eng at firstname.lastname@example.com.
ADDRESS: 1917 Worth Court, Lakewood Ranch
WEB SITE: www.coastalorthopedics.com
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- Mar
22 5th Annual Ponies for Pups
11:30 am - Mar
22 Lakewood Ranch Community Fund 'Havana Nights' Gala
6:30 pm - Mar
23 The Bridal EXPO
12:00 pm - 4:00 pm - Mar
26 LWRBA March Executive Briefing
7:30 am - 9:00 am - Apr
16 USF Sarasota-Manatee HospitaBull Evening
6:00 pm - May
2 2nd annual Glow Run
7:00 pm - 10:00 pm
Tick Tock
Daylight Saving Time starts 2 a.m. Sunday, so be sure to set your alarm accordingly. -
Good vibrations
The Tabernacle Christian School middle school student Lauren Medred, an East County resident, earned top vocal honors, taking first place in vocal solo female category of the Florida League of Christian School's Festival of the Academics and Arts Feb. 28 and March 1 at Southeastern University in Lakeland. -
Tech takeover
Manatee County schools dominated a state technology competition with five of six top-three finishes earned by Manatee County schools during the 35th annual Technology Student Association State Competition late February.


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Executive Team
UL's Executive Team is a committed group of experts with extensive experience and capabilities. Based around the world, they help guide and lead UL as we advance into our second century.
Keith E. WilliamsPresident and Chief Executive Officer and Trustee | In 1997, Keith was named president, Asia-Pacific Operations for Medtronic Inc. based in Tokyo, Japan. During an eight-year career with Medtronic, he also served as chief quality & regulatory officer and as president, Spinal & Neurological Business Unit. |
Ben Miller Senior Vice President and President, Product Safety » | Sajeev Jesudas President, Verification Services » | |
Sara A. Greenstein President, Environment » | Hiroshi Yamaki Senior Vice President and President, Life & Health » | |
Clyde Kofman Senior Vice President and President, Enterprise Services » | Bill GranaSenior Vice President and President, Workplace Health & Safety » |
Global Leadership
August SchaeferSenior Vice President and Public Safety Officer | Christian AnschuetzSenior Vice President and Chief Information Officer | |
Patrick BoyleSenior Vice President and President, UL University | Terry BradySenior Vice President and Chief Legal Officer | |
Jason FischerVice President and Managing Director, Asia Pacific | Adrian GroomSenior Vice President and Chief Human Resources Officer | |
Michael SaltzmanSenior Vice President and Chief Financial Officer | Gitte SchjotzPresident, Europe and Latin America | |
Weifang ZhouSenior Vice President and Chief Commercial Officer |


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Sportsman Bumper Item # 464527 |
$19.95 |
NEW! SPORTSMAN BUMPER - Magnetic fishing rod and gun holder for the side of your vehicle. This handy accessory will hold three fly rods or two shotguns while you're slipping on/off your waders or stopping for lunch. It's a series of soft, molded rubber clips that stick to the side of your vehicle MAGNETICALLY. Magnets are embedded in the soft rubber so there is no chance of damage to your vehicles surface. COLORS: (1)Black, (2)Orange, (3)Forest-Green
- MAGNETIC for easy placement and removal
- EMBEDDED magnets keeps paint scratch-free
- 3 small clips for fishing rods
- 2 large clips for shotguns and rifles
- Clips are flexible to accommodate double-barrel and over-under shotguns
- Pre-drilled holes for easy mounting at home if you like
>> View Item
Catch-A-Hatch Insect Net Item # 464618 |
$24.95 |
- This is one of Bill's favorites. Designed especially for the fly fisher. This super-compact, long-reach specimen collection net is great for matching the hatch. Totally rust-proof with quick-dry nylon net that springs open to form a 5 x 7 inch net. Telescoping handle extends up to 36-inches. Case Included.
>> View Item
River Camo iPhone 3 Case Item # AQ006 |
$17.47 |
30% OFF! RIVER CAMO iPHONE-3 CASES: Show off your colors and protect your iPhone-3 investment with these tough polycarbonate cases. iPhones snap-in securely, creating a perimeter of protection around your phone. COLORS: (3)Largemouth-Bass, (5)River-Rock, (6)Hunter-Camo
NOTE: These cases do not fit the Iphone 4.
>> View Item
River Cami iPhone Cases Item # AQ008 |
$24.95 |
RIVER CAMO IPHONE CASES - Show off your sportsman's colors and protect your iPhone with these tough polycarbonate cases. iPhones snap-in securely, creating a perimeter of protection around your phone. SPECIFY PHONE: (A)iPhone 3 or (B)iPhone 4 - SPECIFY SYTLE: (1)Brown-Trout, (2)Rainbow-Trout, (3)Tarpon, (4)Bonefish, (5)Striped-Bass, (6)Brook-Trout
>> View Item
Tippetac Item # GT010 |
$10.95 |
NEW! TIPPETAC We've all been there, you want to change patterns, so you grab your fly, clip it off and like that... your fly line and leader float downstream. The TIPPETAC solves that problem. This nifty little tool uses two super strong, rare earth neodymium magnets to make sure it stays where you want it, and a rubber piece with the wedge and slit to keep your tippet close for a quick retie. We've found that placing it on the right side of the chest area (for right handers) works best. It also works great on top of a waist pack. Experiment until you find the place that works best for you. The magnets also function to temporarily hold flies. You will find it's a great place to quickly store a fly or two as you change out your rig.
>> View Item
Loop Tippet Dispenser Item # GT011 |
$29.95 |
THEY'RE BACK! LOOP TIPPET DISPENSER - I still have -- and use my original from the early 90's, the last time they were available here in the States. (They're made in Sweden.) Easy to load with your favorite tippet material while you have your feet up watching TV in the evening. The dispenser contains four large diameter, color-coded empty spools. Load them with 3X or smaller size tippet material. Lightweight and compact, fits into any small
vest pocket or pack. An alternative to common tippet dispensers that hang on the outside of your vest or pack (one less thing for line to snag on). These may not be for everyone, but I really do like mine! (Bob)
>> View Item
Trash Fish Item # GT044 |
$15.95 |
SMITH CREEK "TRASH FISH" - Waste tippet, leader and monofilament management system allows you to easily coil and control the line waste that's created while fishing. The built-in "spent-line-wrangler" allows you to easily coil spent line and retain it to keep monofilament from escaping into the fishing environment, helping to keep our streams clean. Extremely fast and easy to use, the slim design will slide into a pocket or clip to a zinger. Lightweight, high quality anodized marine grade aluminum construction. Instructions included, or watch the video at feather-craft.com.
>> View Item
Mono Master Item # GT045 |
$14.95 |
The "MONO MASTER" is an innovative device for handling and disposing of waist monofilament. Discarded mono lasts around 600 years, and when left streamside it usually ends up tangled around a bush, a heron or a trout. Shove it in your pocket and it tangles with fly boxes and tools, and is often accidentally dropped in the stream anyway. The MONO MASTER is the solution. Simply push waist mono into the slot in the side of the device (just to get it started) and spin the handle. Waist mono is "vacuumed" up instantly. MONO MASTER weighs nothing, holds up to 50 meters at a time, and is simple to empty when you get home. An easy way to prevent waist monofilament pollution.
Field & Stream Magazine proclaimed the MONO MASTER as the "Best of the Best" fishing gadget in 2009.
>> View Item
Fishpond Hook Jaw River Tool Item # HF055 |
$19.95 |
NEW! FISHPOND HOOK JAW RIVER TOOL - It's a bottle opener, line cutter, and tippet gage in one convenient tool! Aerospace aluminum and titanium construction, replaceable razorblade line cutter, bottle opener and a retractor/lanyard attachment hole. Accurate tippet gage from 2X - 7X. Laser engraved. Looks great on the key chain too! COLORS: (1)Pine, (2)Lichen
>> View Item
Cliff's Campfire Casino Item # HG098 |
$44.95 |
CLIFF'S "CAMPFIRE CASINO" Everyone likes a little game of chance. Here's a great way to wait out a storm or wind down with your fishing pals at the end of the day. This compact casino includes 6 dice, a deck of cards, and the greatest board game ever created, Cribbage. All packaged neatly into one of Cliff's famous, indestructible fly boxes. Great gift item!
>> View Item
C&F Pin-On Magnetic Fly Patch Item # HG199 |
$24.95 |
NEW! C&F PIN-ON MAGNETIC FLY PATCH - Easily pins to your vest, pack or hat. Eight strong rare-earth magnets hold flies securely for temporary storage. Great for drying "used" flies before going back into a fly box. A big time saver when fishing the evening hatch. Put a couple extra flies in this on-deck-circle and save time getting in and out of fly boxes.
>> View Item
Upg Fly Badge Item # HG213 |
$19.95 |
NEW! UPG FLY BADGE - Keep your key patterns handy and dry. Attach Umpqua's sleek, unobtrusive patch to your shirt, vest, pack, waders or boat with either the carabineer, pin, or Velcro attachment. Micro-slit foam holds a range of fly sizes securely, while the strong magnetic compartment makes dealing with the small-to-medium size flies almost effortless. 4.75" x 2.875".
>> View Item


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Fontainebleau State Park
[ 7/10 ]
Beautiful trees line this park, which is VERY busy. "Admission" is $1 per person and the park is popular with the locals who us the playgrounds and what I believe is a water slide. It is very warm (hot?) and humid. Lots of low branches so be careful. Most of the sites are spacious but some are very narrow and ours had a big, drying mud puddle right out the front door. Pull through sites are an additional $6. Small, neat, museum and the ruins of an old sugar mill. Good for biking. The park is in an extended drought right now. Good power. Golden access cards are no longer honored for out of state residents.
Everglades National Park, Florida
Flamingo Campground (NPS Campground)
[ 4/10 ]
We were here in Mid May. The $15 rate is for Golden Access in a 50 amp site. The Park had only 2 other campers and I can well understand why. Only 2 loops of "T" section had power and they were NOT marked. There was a tiny note about this amid all the other notes and warnings at the check in kiosk. The road in was blocked in several places for 2 days (we complained) by cut branches from a trimming crew who just drove off and left them. Due to the drought, the park is like a humid desert. All the grass is brown and the trees are stressed. The horse flies are particularly bad this year and I have welts all over my legs and arms where I was bitten. I Had to wear long pants and sleeves to help prevent bites. The temps are in the 90's with about 50% humidity. The boat tours $26 were great and we saw crocodiles, a manatee, several dolphins and other assorted fauna. The flora was fascinating with the poisonous trees, indian mahogany, and the 3 species of mangrove being the most memorable. Everything was awaiting the rains, which have yet to come. I would NOT recommend this time of year for a visit. The park staff was as invisible as the rain and not particularly friendly when finally found. Perhaps because we complained about the branches and tiny lettering on the notification on electric in the campsites.
St Augustine, Florida
Faver-Dykes State Park
[ 6/10 ]
We have a 26 ft 5th wheel that is 12ft tall. Getting in and out of this park was somewhat of a trial. There are MANY trees that crowd the nearly (total) 4 miles of the narrow sandy access road to get in and out. While part is separated "one way" the bulk of it is a very narrow 2 lane. Fortunately we met no other vehicles both coming and going. The park is currently VERY dry and has had one recent fire that burned almost a 100 acres (in a remote part of the park) according to the ranger. Power was good, and water pressure was (50 psi). The park ranger (only 1 that we saw) was very friendly and effective but seemed stressed. We had a pleasant stay and visited nearby ST Augustine, about 20 miles away. This was an easy day trip.
Lubbock, Texas
Camelot Village RV & Mobile Home Park
[ 6/10 ]
A couple of notes that will help here. The park was easy to find with our Garman GPS although the access freeway (289) is under construction and the approach VERY narrow. This park accepts only checks or cash. No credit cards. The day clerk was very nice and efficient. washers are $1 and dryers in 25 cent increments. No cable TV, although there is a connection. The quoted rate of $22 is for a back-in site. Pull-throughs are $24.50. Verizon cards worked well. No other WiFi.
Fort Stockton, Texas
Parkview RV Park
[ 3/10 ]
We are greatly disappointed as to how we were misled about the rates as this park. We were told $10 to $12 and when we arrived we were told that this applied only to Passport America holders. We never mentioned this in our conversation. The park is VERY complicated to find and was NOT locatable by our Garmin GPS. We were treated like we were stupid on the phone when we call for additional directions. The highway 285 makes an unmarked right turn that you can easily drive past. It is only marked from the opposite (north) direction, and this is VERY hard to see/read. We drove past it twice. The sites need SERIOUS maintenance, (electric boxes all trashed/corroded), sewer connections buried in the weeds, and 80 psi water pressure that we were NOT warned of. We will NOT return.
Beaver Creek, Yukon
Lake Creek Campground (Yukon Government)
[ 7/10 ]
We really liked this park. Some of the sites were a bit tight, and there were only 2 stream side sites, but it was mainly empty most of the time, filling only in the evenings as most campers, as we were, were there only over night. We stayed there both ways going and coming to Alaska. There was plenty of fire wood and things were in good repair except for one pit toilet which had a broken seat pin. No camp host.
Whitehorse, Yukon
Caribou RV Park
[ 9/10 ]
Of the 3 parks here in Whitehorse, we liked this one the best. The water pressure is a little high, and you have to use a dump station but the sites are mostly shaded, our party (3 rigs) was able to get all our rigs in, including a 40 footer. The camp has a Swiss flavor (the manager and staff all seem to be swiss) and many of the guests are European. The facilities are mostly spotless, the wifi is good from the center, and the laundry is $2. They allow clothes lines so we air dried our as the dryers are $3 for 50 minutes. There is a Swiss restaurant on site that serves authentic schnitzel and yagersschnitzel. Compared to many of the places we have stayed recently, this is one of the better ones. They seem to adjust their rates according to demand, or perhaps because demand is down here, they have reduced them. We paid considerably less than the posted price.
Fort Nelson, British Columbia
Triple G Hideaway
[ 4/10 ]
The water quit shortly after checking in. This took over an hour to be remedied. The Wifi was VERY weak, and slow, and accessible only from the laundry or near the office. The mosquitos ate me alive while I waited. The final negative was the shell of the burned out maintenance building with its collection of incinerated ATV's which had been pulled outside and abandoned. While this was mostly obscured by the trees, it was still there and had been that way for awhile. What a huge, junky, neglected mess.
Pink Mountain, British Columbia
Sikanni River Campground & RV Park
[ 9/10 ]
Picturesque park on the Siskini River. Spacious, quiet sites with the sound of the river in the background. (20 amp locally generated power) Great camp hosts. Old Alaska Highway is just across the river. Several quaint, humorous elements that we enjoyed. If we pass that way again, well stay again.
Sublimity, Oregon
Silver Falls State Park
[ 8/10 ]
Love this park. We stayed in site D-80 (which has a sewer connection), one of the few in the park. It was clean and shady but located in the loop filled mostly with tenter's. The sites were much smaller than in the RV only loop. The campsites were immaculate and the park regularly patrolled by paid, adult, staff as well as 2 camp hosts. My primary complaint about the park is the dump station which is WELL away from the park itself and difficult to find if you don't know where it is. However the falls, rain forest canyons, and lush vegetation make this inconvenience minor
Port Orford, Oregon
Cape Blanco State Park
[ 8/10 ]
Quiet, peaceful, deep sites with water and electric. The dump station is closed indefinitely until it is completely rebuilt. Little to no AT&T with weak Verizon coverage (air card). Satellite is tough because of all the trees. Only one host in October. Sites are level and well kept. High water pressure (70 psi at site #8) so use caution.
Lakeside, Oregon
William M. Tugman State Park
[ 7/10 ]
This late in September the only sites that were really in demand were the Yurts. The park is immaculate, the sites deep (particularly the outside of the loops) and very well cared after by the mostly volunteer staff. The reservation policy was still in effect here and almost every site that was not occupied said "1 or 2 day use", even when the park was mostly empty. Without a reservation the most you could count on was two days. If you are unlucky in the reservation lottery, you have to move from a site that has been reserved, because the reservation system does not know you are there. They come around every morning and tell you if you need to move. ugh. If you want to go through the reservation system, it costs $6 through reserveamerica just to retain the site you are already in. And you can't do this within 48 hours of the requested reservation. Our other issue was the road noise from Hwy 101. When the wind is right, and you are outside, its there. An annoyance in an otherwise great park.
US Air Force Academy, Colorado
Peregrine Pines FamCamp (Military Camping Only)
[ 8/10 ]
A facility intended to support the military academy that accepts associated personnel. The sites range from crowded to spacious. The new Wi-Fi works great and the laundry and baths were the cleanest and most modern that we have encountered in a long time. The camp was dusty though in June. All the sites were gravel. The water pressure was high and needed a reducer. The base gas station has no diesel. A nice place and we recommend it. (ADMIN NOTE: the phone number of (719) 333-4980 shown above is good on weekdays during May - Nov. During Nov-Apr, the phone number is (719) 333-4356.)
F. E. Warren AFB, Wyoming
Crow Creek FamCamp (Military Camping Only)
[ 6/10 ]
This is an AF Family Camp intended for military personnel and related personnel. The base was originally an army frontier fort from the Indian wars and has some great history. It is mostly red brick and very laid back. It must be accessed through Missile Drive as the main gate side of the base has several narrow tunnels with less than 10 ft of clearance. The camp is shaded but the trees are leaking a sticky sap that coats everything in June. Not sure how long this lasts. There are a small Commissary, Bx and Gas station. No Diesel. They observe all the military traditions and this can get inconvenient.
Muldraugh, Kentucky
Camp Carlson Army Recreational Area (Military Camping Only)
[ 7/10 ]
Fort Knox/Camp Carlson This military personnel RV park has recently been renovated with many upgrades. The staff was very helpful. The park was mostly full and we were not able to get a full hookup, making a trip to the dump station imperative. Ugh!!! It was the first dump station we have encountered where the sewer hose had to be stretched around a telephone pole to its destination. Not sure who designed this mess, but it surely was someone who did not have a clue about RV's. The spaces were mostly gravel with numerous pull through's and many trees. There was no cell phone coverage but the park does have free WI-FI which had great download speeds but the upload speed was only 40K. Satellite coverage was fine as there were enough gaps for good reception. However the pads are mostly gravel and many do not have full hookups. The club house was new with a room full of washers and dryers ($1 each). The Patton Museum is a must see with the high point for me being a "cut away" Tiger Tank. The best tank museum I have seen. But alas the much publicized gold vaults are very much off limits and very much underground. The BX and Commissary complex is one of the largest and best stocked that we have seen. The gas station also sells diesel which was very convenient. The rate we received was with a golden access pass. The park is located off base and not easy to find the first time.
Leitchfield, Kentucky
Moutardier COE
[ 8/10 ]
A beautiful Corp of Engineers park that is very well kept. Some of the turns are very tight and not accessible for big rigs, no matter what length the sites are. They were not at all that helpful when spoken to on the phone. The camp hosts were cold and distant although polite. We camped here to see Mammoth Caves when we were told their (Mammoth Caves) campground was full, which was not true. During the week the campground was mostly empty in mid May but filled up completely on Memorial Day weekend. Noise was a minor issue as many campers were "younger" and had the sounds to prove it. Quiet hours were observed though.
Fort Campbell, Kentucky
Destiny Parks and Pavillion (Military Camping Only)
[ 6/10 ]
Fort Campbell RV Park – Intended to support active military service members, dependents and associated personnel. Definitely one of the hardest parks to find that we have encountered. Located off base and accessed by one of the many gates that go seemingly nowhere or for such obscure purposes that are not discernible. There is lots construction and several roads were closed. Use US 374 to Lafayette Rod to get to Gate 10. Getting around is tough even with a base map (get @ visitors center - but gate is under construction closed and must be accessed from off base) The park is in two halves, with one we used, the Eagle Nest, having ONLY 50 + 20 amp service, no 30. It also has no baths or laundry. The other park (?) has these. The park is accessed over a narrow (one lane) bridge past Out Door Recreation (check in there). Sites are reasonably level with full hookups but have many puddles if it rains. Some sites have very low branches so be careful. The PX and Commissary are the largest I believe we have ever encountered and were well stocked. The base is not easy to navigate as most streets are curved or intersect. Being an airborne base (101st) there is lots of chopper traffic till about 10 pm. Not bad, but there. With a Golden Access pass we paid $15 per night. Water pressure is high so use a reducer. There is fishing for the kids which was nice.
Little Rock AFB, Arkansas
Little Rock AFB FamCamp (Military Camping Only)
[ 7/10 ]
The little Rock AFB Family Camp is open to military, active and retired, government employees and to guests of the Airmen who are stationed there. It is spacious but all the sewer hookups are back in. There are two wings with the back wing being more isolated. The sewer connections are only on the outside loop, none on the interior concrete pads. The pads are reasonably level and well drained. Its quiet and surrounded by large trees. The streets on Little Rock AFB are not well marked but the essential services are all there. Check in is @ Family Rec in Bldg 460 which is also the Data Center on one side, opposite where you check in. We would stay there again.
Texarkana, Texas
Rocky Point COE
[ 8/10 ]
We found getting there very difficult as the campground was VERY poorly marked from highway 59. Look for the Shell station. The entrance is next to it. We really like this place. The lake is great and the majority of the sites are very well shaded. Most you can reserve but a minimum number are first come first served. Not all sites have sewer hookups however. We would definitely camp here again. The Golden Access pass halved the daily rate.
Cedar Hill, Texas
Cedar Hill State Park
[ 5/10 ]
The official rate of $20 per night is greatly misleading. This only applies if you are a Texas State Parks Pass holder. There is lots of traffic, boom boxes and speeding vehicles. This is a Saturday and it would probably be quieter if it was a week day, however this is speculation. All the sites are back-in. The tall grass prairie is beautiful but there is not enough of it. There is plenty of local shopping which is a plus. Not sure if we would camp here again.
Hico, Texas
City of Hico's Bosque River RV Park
[ 7/10 ]
Quiet, city park. On the Bosque River. Pay for site in town at city hall, 1/2 mile away. Very reasonable rates and the park is mostly empty. Sites are not well marked and there are numerous connections for a single site. Very unusual. Lots of grass and trees. A 16K restriction on the bridge going into the park and it is single lane, but short. Sites are level but there are many ruts in the access roads. We would camp here again as it is VERY relaxed and quiet, at least during the week. We were the only rig there.
Round Rock, Texas
Old Settlers Park
[ 7/10 ]
Not crowded. Great Verizon reception. Park is in 2 separate parts/sections. One in front, the other in back. Office hours are somewhat limited. Located next to Dell Diamond minor league baseball park and some, sometimes noisy rail road tracks. Shade is limited and hookups in the front section have sewer hookups that are very hard to see/find, and often have been driven over. Front section has only 30 amps as far as we can tell. The front section where we stayed is clean, level, and all back-in. Most of the other rigs here are here for "professional" reasons, meaning that they work from here. There were no rest rooms nor showers in the front park. The only other RV park near here, Austin RV park, was really dumpy and in a bad neighborhood. The wife refused to stay there.
Capitol Reef National Park, Utah
Fruita Campground (NPS Campground)
[ 7/10 ]
The park is awesome, but Fruita Camp Grounds is a bit limited. If you have a rig much over 20 feet make sure you camp in C-Loop. The generator policy (it was cold, 20's for the lows) is very restrictive (8am to 10 am + 6pm to 8 Pm). Most of the tenter's spent only one night as tenting was very uncomfortable. The volunteer guide who did the Cohab Canyon tour/talk was one of the best I have ever met/heard. It was well worth the 3 hours spent listening and treking up the canyon. A former geology professor with a passion for the park, he did a great presentation in a manner that really made the complex geology understandable..
Zion National Park, Utah
Watchman Campground (NPS Campground)
[ 8/10 ]
Spent the first night in A7 on the river. This was right across from the gravel/cement plant and was noisy till 7pm when they finally quit work. It was quite dusty as there has been little rain/snow. The weather is great for late march. We would recommend staying away from the low numbers in the "A" loop due to the noise. We moved the next morning. The site was level and deep, but very difficult to back into due to several large rocks. As it was the week following Easter the park was crowded and there were few if any ranger led "activities" such as talks, hikes, or children's special events. The park is magnificent and despite the limitations listed above, a great place to visit.
Ely, Nevada
Prospector Hotel and Casino
[ 7/10 ]
This park has VERY reasonable rates for full hook-ups. Gravel/dirt and confusing to get into. Is first come first served. It was full by 4 pm on the Monday following Easter. The $17 is a "winter" rate. Not sure when it goes up. About half the price of the local KOA. Would definitely stay here again, especially as and overnight park.
Redding, California
Sacramento River RV Resort
[ 3/10 ]
A discount is not available if you reserve/register online. The WiFi network was visible but locked down. We were not given an access code. We were greatly disturbed by 3 visits to the rig behind us by the Sheriff's Dept. One vehicle was an unmarked squad car containing 4 detectives. The site was clearly marked but the turns were very tight due to both the turns and vehicle congestion. We had to dig out the sewer dump cap as the grass had grown over it. Our rig would not fit beneath the olive tree of our "pull through" The park is reasonably clean with MANY long term residents who have NOT maintained their rigs. Many in the back half of the park close to the "creek" that joins the river have ripped awnings, screen-less entry doors, and residents in questionable attire. The term "redneck" comes to mind. There also were many nice people with good rigs. They, however, were not where we were parked. Our safety is more important than a good rate. We will not stay there again.


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Lot/land for sale in Wetmore, MI 78,900 USD
Gorgeous, private and quiet waterfront parcel with over 500' of frontage on Lake Tahoe. Tall pines, rolling hills, a building site, storage shed and trails galore are featured. This site is set up to park your RV, hook up to septic and water and revel in the beauty of it all!! Lake Tahoe is the spring-fed headwaters of the Little Indian River and a mecca for waterfowl and wildlife.
Brokered And Advertised By: LAND AND LAKES REAL ESTATE CO.
Listing Agent: AUDREY DESARMO
Get a detailed community profile report via email. Click here to get your copy right away.
Data Provided by Upper Peninsula Association of Realtors
More Information for this listing


text:
Dinnerrr Roasted home-fries from potatoes from my dads garden. Vegan mayo to dip fries into (it's so good!) Sautéed kale from Regeneration (local produce) and sautéed zucchini from Regenetation as well. I love good food.
Awww yeah! That looks so good! Glad you enjoyed! Thanks for the shout-out!
(via wellesleysibs-deactivated201209)


text: A survey found that 95% of adults can't do their kids' math homework! Experts blame new ways of teaching arithmetic for the fact that only five percent of 2,000 adults who participated in the study were able to ace a short math quiz aimed at eight to 12-year-olds. Two-thirds of parents say they're reluctant to help their children with their math assignments for fear of confusing them. Sounds like they wouldn't be much help anyway.


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Related Photo Galleries
The Tuten brothers, Chris and Brian, aren't known for missing too many drag races. The boys had the family hauler loaded with both cars, Brian in X275, and Chris in Outlaw Drag Radial in his multi-colored Fox hatch. Brian made it past Round 1, but given the touch nature of X275, was unable to make it past Round 2. Chris ran into problems in Round 1, ending his Sunday prematurely. Friday and Saturday's rain really hampered the testing efforts of all the racers, and took away valued qualifying hits, as well.


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Comment: Re:It ain't the price (Score 0) 124
Comment: Re:LOL, they can't even give it away... (Score 1) 124
Comment: Re:Other mobile OS? No, thanks (Score 1) 124
Comment: Re:Is that legal? (Score 1) 124
Comment: Re:Does this mean (Score 1) 124
Comment: Re:It ain't the price (Score 1) 124
Comment: Duty (Score 1) 232
+ - Google Fiber to expand in Kansas City area->
Link to Original Source
Comment: Re:Ting (Score 3, Informative) 273
You can configure your Nexus 5, and specific apps and services on it, to not use mobile data in the background. In Settings -> Data Usage scroll down and you will see apps. Select the app, scroll down again and you will see the setting "restrict background data". Check this box and it will stop using mobile data while the app is in the background. This is especially critical for things like Google+, where if you take one HD video it will try to sync it in the background and kill your monthly quota. My kids were making videos with my phone while I slept...
Ting looks like a nice deal, and enthusiastic support. I was very frustrated dealing with Sprint to acquire a SIM for my Nexus 5. They were abhorrent in person at three stores and in online chat as well. That kind of put me off. I did finally manage to get SIMs from Ting real easy like. But the experience put me off even of using Sprint towers.
Besides, T-mobile has been really nice to me. That's worth a few extra bucks.
Stay away from Microsoft Skype on your Nexus 5. It has a known issue that kills the battery. Imagine that.


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Funding opportunities
Physical and biological mechanisms of hMSC induction in the cartilage microenvironment
Funding Type:
Basic Biology II
Grant Number:
Funds requested:
$1 347 551
Funding Recommendations:
Not recommended
Grant approved:
Public Abstract:
Within the shake of a hand, one can tell that bone is hard, skin is soft, and muscle is in between. The physical properties of each of these tissues are important for their distinct functions in the body. At a much smaller scale, a cell uses its sense of 'touch' to determine the physical properties of its surroundings. In this way, cells can discern if they reside in a bone, skin, or muscle microenvironment.
Not only do cells sense the stiffness of their environment, but they also respond to it. The physical properties of the matrix microenvironment direct key cellular decisions including cell division, migration, and cell fate selection. For a stem cell, this information is a valuable cue that instructs it to select a cell fate that matches the physical surroundings. Experimentally, a stem cell becomes a bone cell when grown on a stiff matrix but it becomes a brain cell on a soft one. In the body, a multitude of physical and biochemical cues cooperate to direct intricate cell fate decisions. Relative to well-studied biochemical cues, we are just beginning to understand how cells sense and respond to physical cues. Despite their importance in stem cell biology, we know almost nothing about how physical cues interact with biochemical cues to instruct stem cells to select a specific fate.
Our research seeks to understand how stem cells integrate physical and biochemical cues to select a cell fate. We discovered a specific combination of physical and biochemical cues that, when combined, drive adult human mesenchymal stem cells to select a cartilage cell fate. Culture of these stem cells on a cartilage-like matrix stiffness greatly intensifies their response to biochemical signals to induce cartilage production. By investigating the molecular basis of this response, we have novel insights into the way cells integrate physical and biochemical cues. Building on this foundation, we will uncover new mechanisms by which stem cells sense and respond to their surroundings to select a specific fate. While this research is important for understanding cartilage cell fate selection, these fundamental mechanisms will inform many aspects of stem cell biology, including the maintenance of pluripotency and the selection of multiple cell fates.
Although our primary focus is the discovery of basic cellular mechanisms, our model system has important clinical relevance. More than 6 million Californians suffer from osteoarthritis, a disease characterized by the loss of cartilage physical properties. Understanding the interaction of physical and biochemical cues in cartilage may elucidate the cause of osteoarthritis while advancing new therapies to treat it. Already, our research suggests that the combination of biochemical and physical cues enhances the utility of human mesenchymal stem cells for cartilage repair. The results of our work will be applied to promote development of a stem cell-based therapy for cartilage repair.
Statement of Benefit to California:
This project investigates the cues that direct human mesenchymal stem cells to select a cartilage cell fate. Despite the fact that this stem cell source is very attractive for stem cell-based cartilage repair, several obstacles have limited its clinical application. Our research has identified a novel combination of biochemical and physical cues that overcomes a number of these obstacles. Although we still do not understand how these cues exert their beneficial effects, this strategy has significant therapeutic potential. By investigating the mechanisms by which these cues promote cartilage cell differentiation, this research may advance the translation of these findings to a clinical setting, which would have significant impact on the state of California.
Approximately 6 million adults in California, or 27% of the population have some form of arthritis. This disease costs California nearly $32 billion each year, with an estimated $23.2 billion spent on direct medical care and $8.3 billion due to lost wages. Osteoarthritis is a disabling disease that limits the ability to engage in the regular physical activity that prevents obesity, diabetes, and cardiovascular disease. Consequently, successful development of improved arthritis therapies will benefit the health of a significant portion of the California population.
In addition to the health of Californians, cell-based therapies for arthritis and other musculoskeletal conditions provide a huge commercial opportunity for California industry. Support from Proposition 71 increases the likelihood that such therapies are developed in partnership with California companies. Clearly their economic success will provide employment opportunities for Californians, tax revenue for the state, and help maintain California as a world leader in biotechnology research and development.
Finally, by investigating the cellular response to physical cues, this work has implications for other stem cell based-therapies as well as for biomaterials design. Physical cues that promote a specific cell fate decision can be engineered into novel biomaterials that are used to deliver stem cell-based therapies to any target tissue. Again, these advances have the potential to improve the health of California citizens and to create commercial opportunities for California biotechnology companies.
Review Summary:
This proposal is focused on identifying molecular mechanisms underlying the differentiation of human mesenchymal stem cells (hMSCs) into cartilage cells (chondrocytes). The applicant presents preliminary data supporting a synergistic effect of substrate stiffness and a biochemical signaling molecule on chondrocyte differentiation and proposes to study the intracellular signaling pathways downstream of these cues. In Aim 1 the applicant proposes an in-depth analysis of known targets of this signaling molecule, including gain- and loss-of-function experiments as well as evaluation of the roles of cellular localization and post-translational modification. Aim 2 comprises similar experiments to identify targets downstream of substrate stiffness. Finally, in Aim 3, the applicant will evaluate whether the mechanisms of hMSC differentiation into chondrocytes identified through Aims 1&2 in two-dimensional cultures are also at work in traditional three-dimensional hMSC cultures.
Reviewers found the proposal innovative in its focus on the signaling mechanisms underlying mechanosensitive differentiation. However, they felt that the novelty of the experimental system was overstated. Reviewers noted that the substrate basis of this system is not novel and has shortcomings, which are not specifically addressed in the application. The applicant mentions that the preliminary data were generated using a novel cross-linker for the substrate, however the identity of the reagent was not disclosed, making it harder to evaluate the significance of the results. Reviewers did feel that the proposal, if successful, could have a significant impact on the development of therapies for arthritis.
Reviewers raised a number of concerns about the research plan that lead them to question its feasibility. They noted that Aim 1 is well described, but Aims 2 and 3 are less so. Aim 3 is largely disconnected from the first two aims, as there is no clear attempt to control substrate stiffness in the three-dimensional culture model. In addition, the project timeline shows work on Aim 3 starting at the beginning of Year 1, despite its dependence on data obtained in Aims 1 and 2. Reviewers also questioned aspects of the experimental design and would have appreciated additional technical detail. For example, they wondered if the proposed analysis of only two cell lines would be sufficient, considering that shRNA expression can vary widely among stable clones. They also questioned why the non-inductive substrate stiffness proposed in Aim 1 differs from that used to generate the preliminary data. While reviewers found the preliminary data to be generally supportive of the proposal's hypothesis, they felt it lacked a certain degree of scientific rigor. The reported increases in cartilage cell markers are relatively modest and rely on mRNA analysis, not measurement of protein expression. In addition, use of a positive control in these experiments would have been helpful to demonstrate how close the values are to those obtained from differentiated cartilage cells or cartilage tissue. Finally, not all preliminary data included rigorous statistical analysis, making it difficult to interpret their significance.
Reviewers agreed that the research team is strong, particularly in signaling pathway biology and chondrogenesis. They described the PI and co-investigator as well-published and well-funded, with adequate expertise to carry out the proposed experiments. Reviewers did worry that the lack of technical detail in the proposal could indicate a lack of familiarity with the proposed methods. They appreciated the letter of support from an investigator with extensive knowledge of biomaterials, although it was unclear how the substrate material described in that letter would be used.
Overall, while reviewers appreciated this proposal's mechanistic focus and strong research team, they raised a number of concerns about the experimental design and preliminary data that led them to question its feasibility.


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Yeasty, smooth and round, with tropical-fruit aromas. Melon, apple, and nutmeg/cinnamon aromas are pretty nice while the... Read more.
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The secret of sparkling wines is the blend, whether they are from Champagne or other regions of France. This is the winemaker's art. It is the choices he makes that determines what is often referred to as the House style. The style of Charles de Fère is to voluntarily refuse territorial limits, building close partnership relations with growers so that we can select cuvées from northerly vineyards for their freshness and elegance, together with cuvées from southern vineyards for ripe fruit, body and smoothness. This bold approach adds finesse, structure, and a complex harmony of flavors that makes Charles de Fère what it is today.


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Artist: | Freeway |
Title: | HAM Extreme |
Album: | Diamond in the Ruff |
Producer: | Young L (of The Pack) |
Avg Rating: |
Back in January, Kanye West and Jay-Z taught listeners everywhere that H.A.M. isn't just something you eat for breakfast (or not, depending on your faith). Today, Freeway is here to do them one better – not satisfied with going as "Hard as a motherf*cker," the Philly street … Read More