text:
Discover Chocolate and Live La Vida Cocoa!
Search Members
Glendale, AZ, United States
BC, Canada
New Orleans, LA, United States
chicago il, United States
melbourne vic, Australia
kwa zulu natal, South Africa
San Francisco, CA, United States
City, Mexico
Chicago, IL, United States
Homer, Alaska, United States
Sydney, NSW 2750, Australia
Charlotte NC, United States Minor…
West Fulton, NY, United States
vancouver, Canada
Calgary,Alberta, Canada
Palm Springs, United States
Larchmont, United States
Welcome toThe Chocolate Life
Sign Upor Sign In
Follow Clay on: Twitter :: @DiscoverChoc F'Book :: TheChocolateLife F'Book Group :: LaVidaCocoa Paper.li :: @DiscoverChoc
Get Badge
© 2014 Created by Clay Gordon.
Badges | Report an Issue | Terms of Service
Please check your browser settings or contact your system administrator.


text:
Denali LED Lighting... When bright isn't bright enough!Our Denali LED lights are specifically engineered to provide maximum brightness with minimum power draw from your motorcycle. The Denali LED driving light lineup has the right light option for your bike and your riding style, at the right price! |
Denali Lighting 2013 Product Catalog
$0.00 -
Denali DX Xtreme Spot Dual Intensity LED Lighting Kit with Full Wiring Harness and M8 Mount
$389.99 -
Denali Switch Mount For Vertical Perch Bolts
$9.99 -
Denali Universal Articulating Mounts to fit Denali DM, D1, D2 & DX Auxiliary LED Headlights

subset: commoncrawl


text:
Anne Frank: An Unauthorized BiographyHeinemann Profiles examines the lives of people who have contributed to the history of the last century. Each of these fascinating unauthorized biographies tells the story of an important individual and analyzes their achievements, beginning with their lives as young people. The introduction explains the impact the person has had on the twentieth century, then substantiates this with personal history, quotations, primary sources, and photographic evidence. |
What people are saying - Write a review
Review: Anne Frank
User Review - Janice Villwock - Goodreads4th-6th Independent Read Tames chronicles the life of Anne Frank in more of a story setting than just a factual book. There are many photographs in black and white to follow the text along with ... Read full review
Common terms and phrases
1925 Otto Frank 263 Prinsengracht Aachen Adolf Hitler ALGEMEEN ALGEMEEN Allied troops Amsterdam Anne and Margot Anne Frank's diary Anne recorded Anne's diary arrested and sent attic Auschwitz Auschwitz-Birkenau began Bergen-Belsen betrayed bicycle Birkenau bookcase Britain British cards clothes concentration camp death died downstairs Dussel Fritz Pfeffer Dutch Jews Dutch Nazis Dutch resistance eaten Edith and Margot eight Elli Vossen Europe fighting floor forces France Frank family move Frank married Edith Franken Frankfurt German army German troops Germany invades Germany's go into hiding heard helpers hiders invade the Netherlands Jewish July June 12 Kitty Koophuis Kristallnacht later March Margot and Anne Margot join married Edith Hollander Miep Gies Miep Santrouschitz mother National Socialist German Nazi Germany Nazi party night noise November Otto Frank married Otto Frank moves Otto's persecute Prank secret annex September Socialist German Workers Sturtnabteilungen swastika teenager Voskuijl warehouse Westerbork World writer


text:
Good Work(s) Tornado Relief T-Shirt
SALE $21.44 was $32.00 Item #43560TORNADO- All-over foil graphic burnout t-shirt
- Good Work(s) is giving back 50% net profits from the sale of this shirt to United Way Tornado Relief
Sorry, this item is currently unavailable
Special Orders
Select styles are available for special orders. To check for special order availability,
please submit your request below. We will process your request and notify you via email
with the updated status of this item. Merchandise is not guaranteed. Shipping charges will
apply with special orders.
The information you provide below is for this product request only. It will not be added to our marketing database.


text:
Lucas, Eveden Hail Victory at Haw Ridge Xduro(Oak Ridge, TN) – Local runners dominated the field at yesterday's XTERRA Haw Ridge Xduro Trail Run as Barry Lucas, 42, of Maryville and Sally Eveden, 53, of Knoxville placed first in their respective divisions. Lucas finished the 20 kilometer trail run in just 1:14:03 and was able to claim victory over runner-up Mark Rasnake, 35, of Knoxville by more than 10 minutes. Eveden, who finished in 1:42:27, had an even larger lead on her opponent Karen Wilkinson, 42 and also from Knoxville, who crossed the finish line in 1:55:14. This was the first time Tennessee residents were given a taste of XTERRA's new, half-marathon distance Xduro trail races. The runners, who ranged in age from 15 to 63, enjoyed a picture perfect autumn day with falling leaves, clear skies and light winds. According to race director Kevin Mahan, "The woods were cool, the venue was quite scenic, and we all had fun. Everyone was a winner at the XTERRA Haw Ridge Xduro." Since this was the first race in the 2008-09 XTERRA Tennessee Trail Run Series, athletes still have three more opportunities to earn points toward their series total for their chance to win free entry to the XTERRA Trail Running National Championship taking place in Bend, Oregon in September 2009. Runners who finished yesterday's race in less than 3 hours automatically qualify for both Nationals and the XTERRA Trail Running World Championship in Hawaii. Complete race results are attached and more information can be found online at www.xterratrailrun.com. Media interested in photos from this event should contact firstname.lastname@example.com. |
My Account Press & Media Privacy Policy Refund Policy About Contact Sponsors Foundation Feedback
© 2014 TEAM Unlimited LLC |


text:
Our Mission
In effort to increase energy conservation awareness and reduce energy consumption, Metro Group and local utility providers have teamed up to offer energy conservation incentive programs through "Conserve Energy with Metro Group".
Our goal is to:
With our program, all clients who qualify WILL experience immediate & continuous savings on their energy bill.
Just from the savings alone pays for the project!
Contact Us Now!
You'll love how easy it is to participate!
Current Promotion
If you have any outdated T12 fluorescent, HID & incandescent lighting in your business, upon approval by your local utility provider, we'll convert them to new energy saving T8, T5, CFL, LED & MH lighting
at a Minimal to No Cost!
For a limited time, as a part of nationwide effort to reduce energy consumption,
Metro Group and your local Utility Provider are sponsoring Energy Conservation Incentive Programs for Local Businesses by combining both the utility incentives and Metro Group incentives. As we're dedicated to save the environment for the future generation, with our promotion, any qualifying local business customers are able to take advantage of Lighting Rebate Programs.
We cater to small to large commercial customers of Seattle City Light, Puget Sound Energy & Snohomish PUD for all their energy conservation & conversion needs.
Our mission is to convert/replace the old inefficient lighting to new energy efficient devices that will save energy and produce better lighting, as well as providing alternative options for lighting solutions.
It's easy to participate and we'll take care of the conversion process at your convenience.
Best of all, saving energy means lower Energy Bill!
We're Serving:
Up To No Cost?
If You Are:
Rebate available up to No Cost, rebate covers the upgrade cost
Rebate available up to 50% of upgrade cost
Rebate available up to 90% of upgrade cost
Rebate available up to 70% of upgrade cost
Rebate available up to 90% of upgrade cost
Contact Us Now to find out how!
Check out the FAQs |
Recent Projects & Pics
Click Here! |
Contact Us Now!
1. Please print, fill out & sign the Application:
Download Seattle City Light Application (PDF)
Download Puget Sound Energy Application (PDF)
Download Snohomish PUD Application (PDF)
Download Tacoma Power Application (PDF)
2. Fax to: (888) 887-0939 or Email to: email@example.com
3. Our energy consultant will contact you & visit your location to assist you with pre-approval.
*Click Here to Submit Request Online
More Information
About Metro Group
Conserve Energy is a registered trade name of Metro Group, LLC
Fully Licensed, Insured & Bonded.
- » Fluorescent Lamps
- » Electronic Ballast
- » Fluorescent Fixtures
- » HiBay Fixtures
- » Wall Packs
- » Retro-Fit Parts
- » LED Exit Signs
- » Compact Fluorescent
- » Occupancy Sensors
- » more


text:
Need an account? Sign up!
The London skyline
Zanna and Kleo at the banquet
Sledging in Telegraph Hill Park
Snow in the back garden
Outside the front door
Arbuthnot Road, next to the park
Ed on Jerningham Road
The front of the house.
Trying to get out the gate.
Telegraph Hill Park
Ed at the Banquet 2009
Ed at the Taruithorn Banquet 2009
The Full Entourage
The Entourage Waits in the Hall
More Outside the Inn
Looking Disinterested After Robing
Waiting to get my Robe
Holding my Certificate
Me looking at my Certificate
Me in the Great Hall
Me Waiting to be Robed
Ed and I Outside from the Library
Mum Yawning, and Papa
The Family in the Inn


text:
Madagascar 3: Europe's Most Wanted - Triple Play (Blu-Ray, DVD and Digital Copy) Blu-ray
Product Details
Certificate: |
Actor: | |
Director: | |
Region: |
Aspect Ratio: |
Sound Information: |
Number of Discs: |
Main Language: |
Dubbing Languages: |
Subtitle Languages: |
Run Time: |
Studio: | |
Theatrical Release Year: |
Your favourite characters are back, in their most hilarious adventure yet! Alex, Marty, Melman and Gloria find themselves on-the-run through Europe in this wildly entertaining and outrageous comedic adventure that film critics are calling "charming and very funny!" (Bill Zwecker, Chicago Sun-Times). With the fame-loving King Julien and the take-charge Penguins along for the ride, the whole crew joins the circus to escape Captain Dubois of Animal Control. Full of high-flying action and colourful new characters, it's a mad extravaganza everyone will love.
Special Features:
- 'Filmmakers' Commentary: View with commentary by Directors Eric Darnell, Conrad Vernon and Tom McGrath
- How to Train Your Dragon Live Spectacular: World Tour Sneak Peek
Get Them to the Train - The Animators' Corner
- Trivia Track
- Big Top Cast
- Deleted Scenes
- Mad Music Mash-Up
- Ringmasters
- Madagascar 3 Roundtable
- Previews:
- Rise of the Guardians
- How to Train Your Dragon: "Fly High" / How to Train Your Dragon Live Spectacular
- Kung Fu Panda: "Kung Fu Fighting" - Carl Douglas version / Kung Fu Panda: Legends of Awesomeness
- Madagascar 3 Video Game Trailer
Delivery & Returns
How long will it take to arrive?
Please check the stock availability notice on your item when placing your order. This item is: In stock | Usually dispatched within 24 hours
Please remember to add postal time (3-5 working days) to obtain a complete estimate of delivery to your door.
How will I know it has been sent?
You will receive an email to confirm when your item has been sent.
You can also check the status of your order and individual items by accessing My Account details and following the prompts.
Please allow 10 working days from dispatch of your order before notifying us of any late deliveries.
It may be advisable to check with your neighbours to see if a parcel has been left with them, check any outhouses you might have where it may be left if it cannot fit through your letterbox and contact your local sorting office to see if the item has been returned to the depot as undelivered and awaiting collection.
If I'm not completely happy with my item?
Please see our returns policy.
Customers who bought this also bought:
There are currently no reviews.


text:
Fresh berries, cream cheese and Pop-Tarts® toaster pastries come together for a patriotic party in your mouth.
Total Time to Serve: 15 Mins.
Servings: 4
A Magical Time is Waiting
What could be more magical than spending some Disney time with your family? Winning an unforgettable Disney Parks vacation from Kellogg!
See More
You can rate and comment on all of our recipes. We want to know which recipes are your favorites.
Find a Recipe and Get Started
Snackpicks Newsletter Sign Up
Find out about new features, coupons and special offers.
Sign Up Now


text:
0cart: $0.00
Harvest more fun and honor tradition with a John Deere party theme.
Search: john deere
Sort By:
Relevance Popularity Top Rated Name Low Price High Price
16 Per Page 48 Per Page 96 Per Page
Viewing Page 1 of 2
John Deere Party Packs
In stock, ready to ship!
Our Price: $18.00
John Deere 2nd Birthday Party Packs
John Deere 1st Birthday Party Packs
Johnny Tractor 1st Birthday Party Packs
Our Price: $22.00
John Deere Pink 1st Birthday Party Packs
John Deere Pink Party Packs
Johnny Tractor Party Packs
John Deere 1st Birthday Personalized Party Theme
Starting At: $9.00
John Deere Tractor 17" Pinata
Our Price: $23.00
John Deere Dessert Plates
Old Price: $3.50
Our Price: $2.75
John Deere Napkins
Old Price: $4.00
John Deere Dinner Plates
John Deere Tractor Cupcake Wrappers and Picks
Our Price: $3.00
John Deere Tumbler
Starting At: $3.00
John Deere Just Because Party Pack for 8
Our Price: $10.00
John Deere Foil Balloon
Our Price: $2.50
Johnny Tractor Plastic Tablecover
Old Price: $6.50
Our Price: $6.00
Johnny Tractor Pinata
Farm Tractor Shaped Jumbo Foil Balloon
John Deere Tractor Flag Banner
Our Price: $5.00
John Deere Toddler T-Shirt
Our Price: $14.00
John Deere 9 oz. Cups
John Deere Invitations
Our Price: $4.00
Johnny Tractor Dinner Plates
Corn Squirters
Our Price: $7.00
White with Black Tractors Matte Balloons
John Deere Pink Dessert Plates
John Deere Pink Baseball Cap
Our Price: $2.99
Johnny Tractor Dessert Plates
John Deere Tractor Jointed Banner
John Deere Pink 18" Pull-String Tractor Pinata
Our Price: $20.00
John Deere Personalized Photo Banner
Starting At: $30.00
John Deere Pink Dinner Plates
John Deere Jumbo Gift Wrap
John Deere Pink Personalized Birthday Banner
Starting At: $19.00
Johnny Tractor Foil Balloon
John Deere Pink Lunch Napkins
John Deere Pink Foil Balloon
John Deere Tractor Confetti
Our Price: $2.00
Tractor Whirls
Johnny Tractor Lunch Napkins
John Deere 1st Birthday Bib
John Deere Tractor Fancy Hanging Cutouts
John Deere Giant Wall Decals
Our Price: $40.00
John Deere Sticker Sheets
John Deere Notepad
Our Price: $8.00
Johnny Tractor Cone Hats
Johnny Tractor Invitations
Johnny Tractor 9 oz. Cups
John Deere Pink 9 oz. Paper Cups
Johnny Tractor Blowouts
Tractor Cake Pan
Our Price: $15.00
John Deere Framed Signature Matte
Our Price: $19.00
John Deere Tractor Molded Candle
Johnny Tractor Birthday - Framed Signature Matte
John Deere 2nd Birthday Dinner Plates
John Deere Tractor Stand-In
Johnny Tractor Sticker Sheets
John Deere Personalized Invitations
John Deere Centerpiece
Our Price: $6.50
Johnny Tractor Personalized Banner
Starting At: $26.00
John Deere Trucker Hat
Starting At: $1.50
John Deere Pink Centerpiece
Farm Tractor Photo Prop
John Deere 1st Birthday Lunch Napkin
Construction Vehicle Cutouts
John Deere Pink T-Shirt
John Deere Personalized Dinner Plates
John Deere Pink Sticker Sheets
Johnny Tractor Centerpiece
John Deere Pink Personalized Photo Banner
John Deere 1st Birthday Dinner Plates
John Deere Thank-You Notes
John Deere Pink Blowouts
John Deere Blowouts
John Deere Personalized Birthday Banner
John Deere Removable Wall Decorations
John Deere Pink 1st Birthday Invitations
John Deere Plowing Through Floor Puzzle
Our Price: $17.00
John Deere 1st Birthday Invitations
John Deere 2nd Birthday Invitations
John Deere Pink Invitations
John Deere Baby/Toddler T-Shirt
Our Price: $4.99
John Deere Pink Framed Signature Matte
John Deere Keepsake Scroll
Johnny Tractor On the Farm Floor Puzzle
Johnny Tractor Thank-You Notes
John Deere Pink Activity Placemats
John Deere Pink 1st Birthday Dinner Plates
John Deere Pink Thank-You Notes
Johnny Tractor Giant Wall Decals
John Deere 1st Birthday Cone Hats
John Deere Pink Bib
Johnny Tractor Personalized Photo Banner
John Deere Pink Giant Wall Decals
John Deere Pink Notepads
The John Deere Party Supplies from BirthdayExpress.com will be sure to thrill any down home country boy or gal! With the signature green and yellow John Deere tractor as the inspiration for this sweet design, our John Deere Birthday Party Supplies are a great way to add a little farm themed fun to your little one's special day.
Want to ensure your party runs as smoothly as a John Deere tractor? Check out our John Deere Party Planning Guide for awesome activity ideas and recipe suggestions. If you really wanna go the extra mile, our selection of all-inclusive John Deere Party Packs will help ensure that you'll have everything need to do to throw an epicly successful John Deere Theme Party.
John Deere Party Supplies are offered exclusively on BirthdayExpress.com. So, if you want to make sure that your kid's birthday party is truly one of a kind, make sure to decorate with our awesomely unique John Deere Party Theme.
© CelebrateExpress.com. All Rights Reserved.CEWEB02


text:
PreK-5th grade educators who are committed to improving teaching and learning through the use of technology have made the Tots and Technology summer conference the must attend event of the year for elementary teachers, administrators, librarians, and technologists. Join other like-minded educators as we share best practices, explore new products and solutions from leading ed tech vendors, and learn new approaches to teaching with technology during this exciting, high energy conference right on the beach in beautiful, historic Galveston, Texas.
Teachers, administrators, librarians, and technology enthusiasts will enjoy a wide variety of sessions led by industry experts, all of which offer CPE credits. You'll come away with best practices, actionable advice, and new lessons on integrating technology and curriculum.Dont miss out on the fun and learning. |
REGISTRATIONSCHEDULEHOUSING AND DIRECTIONSPRECONFERENCE WORKSHOPSCALL FOR PROPOSALSINVITATION TO EXHIBITPhoto BookThis photo book of TCEA's popular Tots and Technology conference provides a comprehensive look at the fun and learning experienced by the educator-attendees at the 2013 conference. Get SupportDownload the 2014 Tots and Technology support letter to give to your administrator. |
Please provide your e-mail address and password to login.


text:
Pacers Sign Dominic McGuire To 2nd 10-Day Contract
The Indiana Pacers announced Thursday that they have signed Dominic McGuire to a second 10-day contract.
McGuire has played in two games for the Pacers this season.
Joel Embiid is out indefinitely after being seen in Los Angeles by a spinal specialist. Read More.
How well has Arizona played without Brandon Ashley? What about Pittsburgh without Durand Johnson? What about Colorado without Spencer Dinwiddie? Read More.
Written by Dan Hanner on Mar 09, 2014
Nerlens Noel is hoping to make his NBA debut in his hometown of Boston on April 4. Read More.
Steve Kerr is currently an analyst with TNT and was previously general manager of the Suns. Read More.
George Beamon was named MVP of the 2014 MAAC Tournament. Read More.
Jarvis Threatt was named tournament MVP. Read More.
The Knicks have acquired the right to operate an NBA D-League team that will play in White Plains, New York. Read More.
Dell Demps said Monday there are no guarantees that the Pelicans will sign Pierre Jackson to a contract for next season. Read More.
Anas Osama Mahmoud is a 7'2 center from Egypt who is averaging 17 points and 12 rebounds for West Oaks Academy in Orlando. Read More.
Step 1: Select the Teams
Choose at least two teams from the menus below to start your trade.
All content © 2000-2014 RealGM, L.L.C. All rights reserved.


text:
RxNorm Names
RIZATRIPTAN BENZOATE tablet
[Teva Pharmaceuticals USA Inc]
Permanent Link:
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4ef60c83-ba48-4134-968b-13800ea9b7f2Category | DEA Schedule | Marketing Status |
HUMAN PRESCRIPTION DRUG LABEL | Abbreviated New Drug Application |
HIGHLIGHTS OF PRESCRIBING INFORMATIONThese highlights do not include all the information needed to use rizatriptan benzoate tablets safely and effectively. See full prescribing information for rizatriptan benzoate tablets.
RIZATRIPTAN benzoate tablets for oral use Initial U.S. Approval: 1998 RECENT MAJOR CHANGESIndications and Usage Acute Treatment of Migraine (1) 12/2011 INDICATIONS AND USAGERizatriptan benzoate tablets are a serotonin (5-HT)1B/1D receptor agonist (triptan) indicated for the acute treatment of migraine with or without aura in adults and in pediatric patients 6 to 17 years of age (1) Limitations of Use: DOSAGE AND ADMINISTRATIONDOSAGE FORMS AND STRENGTHSRizatriptan benzoate tablets: 5 mg and 10 mg (3) CONTRAINDICATIONS
ADVERSE REACTIONSThe most common adverse reactions in adults were (incidence ≥ 5% and greater than placebo): asthenia/fatigue, somnolence, pain/pressure sensation and dizziness (6.1) To report SUSPECTED ADVERSE REACTIONS, contact TEVA USA, PHARMACOVIGILANCE at 1-888-838-2872, X6351 or email@example.com; or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. USE IN SPECIFIC POPULATIONS
See 17 for PATIENT COUNSELING INFORMATION and FDA-approved patient labeling. Revised: 12/2012 |
Rizatriptan benzoate tablets are indicated for the acute treatment of migraine with or without aura in adults and in pediatric patients 6 to 17 years old.
Information related to usage of rizatriptan benzoate in pediatric patients (6 to 17 years old) is approved for Merck & Co., Inc.'s Rizatriptan Benzoate Tablets. However, due to Merck & Co., Inc.'s marketing exclusivity rights, this drug product is not labeled with that pediatric patient (6 to 17 years old) usage information.
Limitations of Use
- Rizatriptan benzoate tablets should only be used where a clear diagnosis of migraine has been established. If a patient has no response for the first migraine attack treated with rizatriptan benzoate tablets, the diagnosis of migraine should be reconsidered before rizatriptan benzoate tablets are administered to treat any subsequent attacks.
- Rizatriptan benzoate tablets are not indicated for use in the management of hemiplegic or basilar migraine [see Contraindications (4)].
- Rizatriptan benzoate tablets are not indicated for the prevention of migraine attacks.
- Safety and effectiveness of rizatriptan benzoate tablets have not been established for cluster headache.
2.1 Dosing Information in Adults
The recommended starting dose of rizatriptan benzoate tablets is either 5 mg or 10 mg for the acute treatment of migraines in adults. The 10 mg dose may provide a greater effect than the 5 mg dose, but may have a greater risk of adverse reactions [see Clinical Studies (14.1)].
Redosing in Adults
Although the effectiveness of a second dose or subsequent doses has not been established in placebo-controlled trials, if the migraine headache returns, a second dose may be administered 2 hours after the first dose. The maximum daily dose should not exceed 30 mg in any 24 hour period. The safety of treating, on average, more than four headaches in a 30 day period has not been established.
2.2 Dosing Information in Pediatric Patients (Age 6 to 17 Years)
Information related to dosage of rizatriptan benzoate for pediatric patients (6 to 17 years old) is approved for Merck & Co., Inc.'s Rizatriptan Benzoate Tablets. However, due to Merck & Co., Inc.'s marketing exclusivity rights, this drug product is not labeled with that dosage information.
2.4 Dosage Adjustment for Patients on Propranolol
Adult Patients
In adult patients taking propranolol, only the 5 mg dose of rizatriptan benzoate tablets is recommended, up to a maximum of 3 doses in any 24 hour period (15 mg) [see Drug Interactions (7.1) and Clinical Pharmacology (12.3)].
Pediatric Patients
Dosage adjustment information of rizatriptan benzoate for pediatric patients (6 to 17 years old) taking propranolol is approved for Merck & Co., Inc.'s Rizatriptan Benzoate Tablets. However, due to Merck & Co., Inc.'s marketing exclusivity rights, this drug product is not labeled with that dosage adjustment information.
Rizatriptan benzoate tablets
5 mg – white to off-white, capsule-shaped tablets, one side of the tablet debossed with the number "93", the other side debossed with the number "7471".
10 mg – white to off-white, capsule-shaped tablets, one side of the tablet debossed with the number "93", the other side debossed with the number "7472".
Rizatriptan benzoate tablets are contraindicated in patients with:
- Ischemic coronary artery disease (angina pectoris, history of myocardial infarction, or documented silent ischemia), or other significant underlying cardiovascular disease [see Warnings and Precautions (5.1)].
- Coronary artery vasospasm including Prinzmetal's angina [see Warnings and Precautions (5.1)].
- History of stroke or transient ischemic attack (TIA) [see Warnings and Precautions (5.4)].
- Peripheral vascular disease (PVD) [see Warnings and Precautions (5.5)].
- Ischemic bowel disease [see Warnings and Precautions (5.5)].
- Uncontrolled hypertension [see Warnings and Precautions (5.8)].
- Recent use (i.e., within 24 hours) of another 5-HT1 agonist, ergotamine-containing medication, or ergot-type medication (such as dihydroergotamine or methysergide) [see Drug Interactions (7.2 and 7.3)].
- Hemiplegic or basilar migraine.
- Concurrent administration or recent discontinuation (i.e., within 2 weeks) of a MAO-A inhibitor [see Drug Interactions (7.5) and Clinical Pharmacology (12.3)].
- Hypersensitivity to rizatriptan benzoate (angioedema and anaphylaxis seen) [see Adverse Reactions (6.2)].
5.1 Myocardial Ischemia, Myocardial Infarction, and Prinzmetal's Angina
Rizatriptan benzoate should not be given to patients with ischemic or vasospastic coronary artery disease. There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a few hours following administration of rizatriptan benzoate. Some of these reactions occurred in patients without known coronary artery disease (CAD). 5-HT1 agonists including rizatriptan benzoate may cause coronary artery vasospasm (Prinzmetal's Angina), even in patients without a history of CAD.
Triptan-naïve patients who have multiple cardiovascular risk factors (e.g., increased age, diabetes, hypertension, smoking, obesity, strong family history of CAD) should have a cardiovascular evaluation prior to receiving rizatriptan benzoate. If there is evidence of CAD or coronary artery vasospasm, rizatriptan benzoate should not be administered [see Contraindications (4)]. For patients who have a negative cardiovascular evaluation, consideration should be given to administration of the first rizatriptan benzoate dose in a medically-supervised setting and performing an electrocardiogram (ECG) immediately following rizatriptan benzoate administration. Periodic cardiovascular evaluation should be considered in intermittent long-term users of rizatriptan benzoate who have cardiovascular risk factors.
5.2 Arrhythmias
Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HT1 agonists. Discontinue rizatriptan benzoate if these disturbances occur.
5.3 Chest, Throat, Neck and/or Jaw Pain/Tightness/Pressure
As with other 5-HT1 agonists, sensations of tightness, pain, pressure, and heaviness in the precordium, throat, neck and jaw commonly occur after treatment with rizatriptan benzoate and are usually non-cardiac in origin. However, if a cardiac origin is suspected, patients should be evaluated. Patients shown to have CAD and those with Prinzmetal's variant angina should not receive 5-HT1 agonists.
5.4 Cerebrovascular Events
Cerebral hemorrhage, subarachnoid hemorrhage, and stroke have occurred in patients treated with 5-HT1 agonists, and some have resulted in fatalities. In a number of cases, it appears possible that the cerebrovascular events were primary, the 5-HT1 agonist having been administered in the incorrect belief that the symptoms experienced were a consequence of migraine, when they were not. Also, patients with migraine may be at increased risk of certain cerebrovascular events (e.g., stroke, hemorrhage, transient ischemic attack). Discontinue rizatriptan benzoate if a cerebrovascular event occurs.
As with other acute migraine therapies, before treating headaches in patients not previously diagnosed as migraineurs, and in migraineurs who present with atypical symptoms, care should be taken to exclude other potentially serious neurological conditions. Rizatriptan benzoate should not be administered to patients with a history of stroke or transient ischemic attack [see Contraindications (4)].
5.5 Other Vasospasm Reactions
5-HT1 agonists, including rizatriptan benzoate, may cause non-coronary vasospastic reactions, such as peripheral vascular ischemia, gastrointestinal vascular ischemia and infarction (presenting with abdominal pain and bloody diarrhea), splenic infarction, and Raynaud's syndrome. In patients who experience symptoms or signs suggestive of non-coronary vasospasm reaction following the use of any 5-HT1 agonist, the suspected vasospasm reaction should be ruled out before receiving additional rizatriptan benzoate doses.
Reports of transient and permanent blindness and significant partial vision loss have been reported with the use of 5-HT1 agonists. Since visual disorders may be part of a migraine attack, a causal relationship between these events and the use of 5-HT1 agonists have not been clearly established.
5.6 Medication Overuse Headache
Overuse of acute migraine drugs (e.g., ergotamine, triptans, opioids, or a combination of drugs for 10 or more days per month) may lead to exacerbation of headache (medication overuse headache). Medication overuse headache may present as migraine-like daily headaches, or as a marked increase in frequency of migraine attacks. Detoxification of patients, including withdrawal of the overused drugs, and treatment of withdrawal symptoms (which often includes a transient worsening of headache) may be necessary.
5.7 Serotonin Syndrome
Serotonin syndrome may occur with triptans, including rizatriptan benzoate particularly during coadministration with selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and MAO inhibitors [see Drug Interactions (7.5)]. Serotonin syndrome symptoms may include mental status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination) and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). The onset of symptoms can occur within minutes to hours of receiving a new or a greater dose of a serotonergic medication. Rizatriptan benzoate treatment should be discontinued if serotonin syndrome is suspected [see Drug Interactions (7.4) and Patient Counseling Information (17)].
5.8 Increase in Blood Pressure
Significant elevation in blood pressure, including hypertensive crisis with acute impairment of organ systems, has been reported on rare occasions in patients with and without a history of hypertension receiving 5-HT1 agonists, including rizatriptan benzoate. In healthy young adult male and female patients who received maximal doses of rizatriptan (10 mg every 2 hours for 3 doses), slight increases in blood pressure (approximately 2 to 3 mmHg) were observed. Rizatriptan benzoate is contraindicated in patients with uncontrolled hypertension [see Contraindications (4)].
The following adverse reactions are discussed in more detail in other sections of the labeling:
- Myocardial Ischemia, Myocardial Infarction, and Prinzmetal's Angina [see Warnings and Precautions (5.1)].
- Arrhythmias [see Warnings and Precautions (5.2)].
- Chest and or Throat, Neck and/or Jaw Pain/Tightness/Pressure [see Warnings and Precautions (5.3)].
- Cerebrovascular Events [see Warnings and Precautions (5.4)].
- Other Vasospasm Reactions [see Warnings and Precautions (5.5)].
- Medication Overuse Headache [see Warnings and Precautions (5.6)].
- Serotonin Syndrome [see Warnings and Precautions (5.7)].
- Increase in Blood Pressure [see Warnings and Precautions (5.8)].
6.1 Clinical Trials Experience
Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.
Incidence in Controlled Clinical Trials
Adverse reactions to rizatriptan benzoate were assessed in controlled clinical trials that included over 3700 adult patients who received single or multiple doses of rizatriptan benzoate tablets. The most common adverse reactions during treatment with rizatriptan benzoate (≥ 5% in either treatment group and greater than placebo) were asthenia/fatigue, somnolence, pain/pressure sensation and dizziness. These adverse reactions appeared to be dose related.
Table 1 lists the adverse reactions (incidence ≥ 2% and greater than placebo) after a single dose of rizatriptan benzoate in adults.
% of Patients | |||
Adverse Reactions |
Rizatriptan Benzoate Tablets 5 mg (N = 977) |
Rizatriptan Benzoate Tablets 10 mg (N = 1167) |
Placebo (N = 627) |
Atypical Sensations | 4 | 5 | 4 |
Paresthesia | 3 | 4 | < 2 |
Pain and other Pressure Sensations | 6 | 9 | 3 |
Chest Pain: | |||
tightness/pressure and/or heaviness | < 2 | 3 | 1 |
Neck/throat/jaw: | |||
pain/tightness/pressure | < 2 | 2 | 1 |
Regional Pain: | |||
tightness/pressure and/or heaviness | < 1 | 2 | 0 |
Pain, location unspecified | 3 | 3 | < 2 |
Digestive | 9 | 13 | 8 |
Dry Mouth | 3 | 3 | 1 |
Nausea | 4 | 6 | 4 |
Neurological | 14 | 20 | 11 |
Dizziness | 4 | 9 | 5 |
Headache | < 2 | 2 | < 1 |
Somnolence | 4 | 8 | 4 |
Other | |||
Asthenia/fatigue | 4 | 7 | 2 |
The frequencies of adverse reactions in clinical trials did not increase when up to three doses were taken within 24 hours. Adverse reaction frequencies were also unchanged by concomitant use of drugs commonly taken for migraine prophylaxis (including propranolol), oral contraceptives, or analgesics. The incidences of adverse reactions were not affected by age or gender. There were insufficient data to assess the impact of race on the incidence of adverse reactions.
Other Events Observed in Association with the Administration of Rizatriptan Benzoate in Adults
In the following section, the frequencies of less commonly reported adverse events are presented that were not reported in other sections of the labeling. Because the reports include events observed in open studies, the role of rizatriptan benzoate in their causation cannot be reliably determined. Furthermore, variability associated with adverse event reporting, the terminology used to describe adverse events, limit the value of the quantitative frequency estimates provided. Event frequencies are calculated as the number of patients who used rizatriptan benzoate and reported an event divided by the total number of patients exposed to rizatriptan benzoate (N = 3716). All reported events occurred at an incidence ≥ 1%, or are believed to be reasonably associated with the use of the drug. Events are further classified within body system categories and enumerated in order of decreasing frequency using the following definitions: frequent adverse events are those defined as those occurring in at least (>)1/100 patients; infrequent adverse experiences are those occurring in 1/100 to 1/1000 patients; and rare adverse experiences are those occurring in fewer than 1/1000 patients.
General: Infrequent was facial edema. Rare were syncope and edema/swelling.
Atypical Sensations: Frequent were warm sensations.
Cardiovascular: Frequent was palpitation. Infrequent were tachycardia, cold extremities, and bradycardia.
Digestive: Frequent were diarrhea and vomiting. Infrequent were dyspepsia, tongue edema and abdominal distention.
Musculoskeletal: Infrequent were muscle weakness, stiffness, myalgia and muscle cramp/spasm.
Neurological/Psychiatric: Frequent were hypoesthesia, euphoria and tremor. Infrequent were vertigo, insomnia, confusion/disorientation, gait abnormality, memory impairment, and agitation.
Respiratory: Frequent was dyspnea. Infrequent was pharyngeal edema.
Special Senses: Infrequent were blurred vision and tinnitus. Rare was eye swelling.
Skin and Skin Appendage: Frequent was flushing. Infrequent were sweating, pruritus, rash, and urticaria. Rare was erythema, hot flashes.
Pediatric Patients 6 to 17 Years of Age
Information relating to adverse reactions to rizatriptan benzoate orally disintegrating tablets in a controlled clinical trial is approved for Merck & Co., Inc.'s Rizatriptan Benzoate Orally Disintegrating Tablets in pediatric patients (6 to 17 years old). However, due to Merck & Co., Inc.'s marketing exclusivity rights, this drug product is not labeled with that information.
6.2 Postmarketing Experience
The following section enumerates potentially important adverse events that have occurred in clinical practice and which have been reported spontaneously to various surveillance systems. The events enumerated include all except those already listed in other sections of the labeling or those too general to be informative. Because the reports cite events reported spontaneously from worldwide postmarketing experience, frequency of events and the role of rizatriptan benzoate in their causation cannot be reliably determined.
Neurological/Psychiatric: Seizure.
General: Allergic conditions including anaphylaxis/anaphylactoid reaction, angioedema, wheezing, and toxic epidermal necrolysis [see Contraindications (4)].
Special Senses: Dysgeusia.
7.1 Propranolol
The dose of rizatriptan benzoate should be adjusted in propranolol-treated patients, as propranolol has been shown to increase the plasma AUC of rizatriptan by 70% [see Dosage and Administration (2.4) and Clinical Pharmacology (12.3)].
7.2 Ergot-Containing Drugs
Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and rizatriptan benzoate within 24 hours is contraindicated [see Contraindications (4)].
7.3 Other 5-HT1 Agonists
Because their vasospastic effects may be additive, coadministration of rizatriptan benzoate and other 5-HT1 agonists within 24 hours of each other is contraindicated [see Contraindications (4)].
7.4 SSRIs/SNRIs and Serotonin Syndrome
Cases of serotonin syndrome have been reported during coadministration of triptans and selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs) [see Warnings and Precautions (5.7)].
8.1 Pregnancy
Teratogenic Effects
Pregnancy category C
There are no adequate and well-controlled studies in pregnant women. Rizatriptan benzoate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
In a general reproductive study in rats, birth weights and pre- and post-weaning weight gain were reduced in the offspring of females treated prior to and during mating and throughout gestation and lactation with doses of 10 and 100 mg/kg/day. In a pre- and post-natal developmental toxicity study in rats, an increase in mortality of the offspring at birth and for the first three days after birth, a decrease in pre- and post-weaning weight gain, and decreased performance in a passive avoidance test (which indicates a decrease in learning capacity of the offspring) were observed at doses of 100 and 250 mg/kg/day. The no-effect dose for all of these effects was 5 mg/kg/day, associated with a maternal plasma exposure (AUC) approximately 7.5 times that in humans receiving the MRDD. With doses of 100 and 250 mg/kg/day, the decreases in average weight of both the male and female offspring persisted into adulthood. All effects on the offspring in both studies occurred in the absence of any apparent maternal toxicity.
In embryofetal development studies, no teratogenic effects were observed when pregnant rats and rabbits were administered doses of 100 and 50 mg/kg/day, respectively, during organogenesis. Fetal weights were decreased in conjunction with decreased maternal weight gain at the highest doses tested. The developmental no-effect dose in these studies was 10 mg/kg/day in both rats and rabbits (maternal exposures approximately 15 times human exposure at the MRDD). Toxicokinetic studies demonstrated placental transfer of drug in both species.
8.3 Nursing Mothers
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when rizatriptan benzoate is administered to a nursing woman. Rizatriptan is extensively excreted in rat milk, with levels in milk at least 5 fold higher than levels in maternal plasma.
8.4 Pediatric Use
Safety and effectiveness in pediatric patients under 6 years of age have not been established.
Information related to the efficacy and safety of rizatriptan benzoate in the acute treatment of migraine in patients aged 6 to 17 years is approved for Merck & Co., Inc.'s Rizatriptan Benzoate Tablets. However, due to Merck & Co., Inc.'s marketing exclusivity rights, this drug product is not labeled with that information [see Clinical Studies (14.2)].
8.5 Geriatric Use
Clinical studies of rizatriptan benzoate did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients.
Although the pharmacokinetics of rizatriptan were similar in elderly (aged ≥ 65 years) and in younger adults (n = 17), in general, dose selection for an elderly patient should be cautious, starting at the low end of the dosing range. This reflects the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Geriatric patients who have other cardiovascular risk factors (e.g., diabetes, hypertension, smoking, obesity, strong family history of coronary artery disease) should have a cardiovascular evaluation prior to receiving rizatriptan benzoate [see Warnings and Precautions (5.1)].
No overdoses of rizatriptan benzoate were reported during clinical trials in adults.
Some adult patients who received 40 mg of rizatriptan either a single dose or as two doses with a 2 hour interdose interval had dizziness and somnolence.
In a clinical pharmacology study in which 12 adult subjects received rizatriptan, at total cumulative doses of 80 mg (given within four hours), two of the subjects experienced syncope, dizziness, bradycardia including third degree AV block, vomiting, and/or incontinence.
In addition, based on the pharmacology of rizatriptan benzoate, hypertension or myocardial ischemia could occur after overdosage. Gastrointestinal decontamination, (i.e., gastric lavage followed by activated charcoal) should be considered in patients suspected of an overdose with rizatriptan benzoate. Clinical and electrocardiographic monitoring should be continued for at least 12 hours, even if clinical symptoms are not observed.
The effects of hemo- or peritoneal dialysis on serum concentrations of rizatriptan are unknown.
Rizatriptan benzoate tablets contain rizatriptan benzoate, a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist.
Rizatriptan benzoate is described chemically as: N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate and its structural formula is:
The molecular weight of the free base is 269.4. Rizatriptan benzoate is a white to almost white, crystalline powder that is soluble in water at about 42 mg per mL (expressed as free base) at 25°C.
Rizatriptan benzoate tablets are available for oral administration in strengths of 5 and 10 mg (corresponding to 7.265 mg or 14.53 mg of the benzoate salt, respectively). Each compressed tablet contains the following inactive ingredients: lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized corn starch, and sodium starch glycolate.
12.1 Mechanism of Action
Rizatriptan binds with high affinity to human cloned 5-HT1B/1D receptors. Rizatriptan benzoate presumably exerts its therapeutic effects in the treatment of migraine headache by binding to 5-HT1B/1D receptors located on intracranial blood vessels and sensory nerves of the trigeminal system.
12.3 Pharmacokinetics
Rizatriptan is completely absorbed following oral administration. The mean oral absolute bioavailability of the rizatriptan benzoate tablet is about 45%, and mean peak plasma concentrations (Cmax) are reached in approximately 1 to 1.5 hours (Tmax). The presence of a migraine headache did not appear to affect the absorption or pharmacokinetics of rizatriptan. Food has no significant effect on the bioavailability of rizatriptan but delays the time to reach peak concentration by an hour. In clinical trials, rizatriptan benzoate was administered without regard to food.
The bioavailability and Cmax of rizatriptan were similar following administration of rizatriptan benzoate tablets and rizatriptan benzoate orally disintegrating tablets, but the rate of absorption is somewhat slower with rizatriptan benzoate orally disintegrating tablets, with Tmax delayed by up to 0.7 hour. AUC of rizatriptan is approximately 30% higher in females than in males. No accumulation occurred on multiple dosing.
The mean volume of distribution is approximately 140 liters in male subjects and 110 liters in female subjects. Rizatriptan is minimally bound (14%) to plasma proteins.
The primary route of rizatriptan metabolism is via oxidative deamination by monoamine oxidase-A (MAO-A) to the indole acetic acid metabolite, which is not active at the 5-HT1B/1D receptor. N-monodesmethyl-rizatriptan, a metabolite with activity similar to that of parent compound at the 5-HT1B/1D receptor, is formed to a minor degree. Plasma concentrations of N-monodesmethyl-rizatriptan are approximately 14% of those of parent compound, and it is eliminated at a similar rate. Other minor metabolites, the N-oxide, the 6-hydroxy compound, and the sulfate conjugate of the 6-hydroxy metabolite are not active at the 5-HT1B/1D receptor.
The total radioactivity of the administered dose recovered over 120 hours in urine and feces was 82% and 12%, respectively, following a single 10 mg oral administration of 14C-rizatriptan. Following oral administration of 14C-rizatriptan, rizatriptan accounted for about 17% of circulating plasma radioactivity. Approximately 14% of an oral dose is excreted in urine as unchanged rizatriptan while 51% is excreted as indole acetic acid metabolite, indicating substantial first pass metabolism.
The plasma half-life of rizatriptan in males and females averages 2 to 3 hours.
Cytochrome P450 Isoforms
Rizatriptan is not an inhibitor of the activities of human liver cytochrome P450 isoforms 3A4/5, 1A2, 2C9, 2C19, or 2E1; rizatriptan is a competitive inhibitor (Ki = 1400 nM) of cytochrome P450 2D6, but only at high, clinically irrelevant concentrations.
Special Populations
Geriatric: Rizatriptan pharmacokinetics in healthy elderly non-migraineur volunteers (age 65 to 77 years) were similar to those in younger non-migraineur volunteers (age 18 to 45 years).
Pediatric: Information related to the pharmacokinetics of rizatriptan in pediatric migraineurs 6 to 17 years of age is approved for Merck & Co., Inc.'s Rizatriptan Benzoate Tablets. However, due to Merck & Co., Inc.'s marketing exclusivity rights, this drug product is not labeled with that information.
Gender: The mean AUC0-∞ and Cmax of rizatriptan (10 mg orally) were about 30% and 11% higher in females as compared to males, respectively, while Tmax occurred at approximately the same time.
Hepatic impairment: Following oral administration in patients with hepatic impairment caused by mild to moderate alcoholic cirrhosis of the liver, plasma concentrations of rizatriptan were similar in patients with mild hepatic insufficiency compared to a control group of subjects with normal hepatic function; plasma concentrations of rizatriptan were approximately 30% greater in patients with moderate hepatic insufficiency.
Renal impairment: In patients with renal impairment (creatinine clearance 10 to 60 mL/min/1.73 m2), the AUC0-∞ of rizatriptan was not significantly different from that in subjects with normal renal function. In hemodialysis patients, (creatinine clearance < 2 mL/min/1.73 m2), however, the AUC for rizatriptan was approximately 44% greater than that in patients with normal renal function.
Race: Pharmacokinetic data revealed no significant differences between African American and Caucasian subjects.
Drug Interactions
[See also Drug Interactions (7).]
Monoamine oxidase inhibitors: Rizatriptan is principally metabolized via monoamine oxidase, 'A' subtype (MAO-A). Plasma concentrations of rizatriptan may be increased by drugs that are selective MAO-A inhibitors (e.g., moclobemide) or nonselective MAO inhibitors [type A and B] (e.g., isocarboxazid, phenelzine, tranylcypromine, and pargyline). In a drug interaction study, when rizatriptan 10 mg was administered to subjects (n = 12) receiving concomitant therapy with the selective, reversible MAO-A inhibitor, moclobemide 150 mg t.i.d., there were mean increases in rizatriptan AUC and Cmax of 119% and 41% respectively; and the AUC of the active N-monodesmethyl metabolite of rizatriptan was increased more than 400%. The interaction would be expected to be greater with irreversible MAO inhibitors. No pharmacokinetic interaction is anticipated in patients receiving selective MAO-B inhibitors [see Contraindications (4) and Drug Interactions (7.5)].
Propranolol: In a study of concurrent administration of propranolol 240 mg/day and a single dose of rizatriptan 10 mg in healthy adult subjects (n = 11), mean plasma AUC for rizatriptan was increased by 70% during propranolol administration, and a four-fold increase was observed in one subject. The AUC of the active N-monodesmethyl metabolite of rizatriptan was not affected by propranolol [see Dosage and Administration (2.4) and Drug Interactions (7.1)].
Nadolol/Metoprolol: In a drug interactions study, effects of multiple doses of nadolol 80 mg or metoprolol 100 mg every 12 hours on the pharmacokinetics of a single dose of 10 mg rizatriptan were evaluated in healthy subjects (n = 12). No pharmacokinetic interactions were observed.
Paroxetine: In a study of the interaction between the selective serotonin reuptake inhibitor (SSRI) paroxetine 20 mg/day for two weeks and a single dose of rizatriptan 10 mg in healthy subjects (n = 12), neither the plasma concentrations of rizatriptan nor its safety profile were affected by paroxetine [see Warnings and Precautions (5.7), Drug Interactions (7.4), and Patient Counseling Information (17)].
Oral contraceptives: In a study of concurrent administration of an oral contraceptive during 6 days of administration of rizatriptan (10 to 30 mg/day) in healthy female volunteers (n = 18), rizatriptan did not affect plasma concentrations of ethinyl estradiol or norethindrone.
13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility
Carcinogenesis: Oral carcinogenicity studies were conducted in mice (100 weeks) and rats (106 weeks) at doses of up to 125 mg/kg/day. Plasma exposures (AUC) at the highest dose tested were approximately 150 (mice) and 240 times (rats) that in humans at the maximum recommended daily dose (MRDD) of 30 mg/day. There was no evidence of an increase in tumor incidence related to rizatriptan in either species.
Mutagenesis: Rizatriptan was neither mutagenic nor clastogenic in a battery of in vitro and in vivo genetic toxicity studies, including: the microbial mutagenesis (Ames) assay, in vitro mammalian cell mutagenesis and chromosomal aberration assays, and the in vivo chromosomal aberration assay in mouse.
Impairment of Fertility: In a fertility study in rats, altered estrus cyclicity and delays in time to mating were observed in females treated orally with 100 mg/kg/day rizatriptan. The no-effect dose was 10 mg/kg/day (approximately 15 times the human exposure at the MRDD). There were no other fertility-related effects in the female rats. There was no impairment of fertility or reproductive performance in male rats treated with up to 250 mg/kg/day (approximately 550 times the human exposure at the MRDD).
14.1 Adults
The efficacy of rizatriptan benzoate tablets was established in four multicenter, randomized, placebo-controlled trials. Patients enrolled in these studies were primarily female (84%) and Caucasian (88%), with a mean age of 40 years (range of 18 to 71). Patients were instructed to treat a moderate to severe headache. Headache response, defined as a reduction of moderate or severe headache pain to no or mild headache pain, was assessed for up to 2 hours (Study 1) or up to 4 hours after dosing (Studies 2, 3 and 4). Associated symptoms of nausea, photophobia, and phonophobia and maintenance of response up to 24 hours post-dose were evaluated. A second dose of rizatriptan benzoate tablets was allowed 2 to 24 hours after dosing for treatment of recurrent headache in Studies 1 and 2. Additional analgesics and/or antiemetics were allowed 2 hours after initial treatment for rescue in all four studies.
In all studies, the percentage of patients achieving headache response 2 hours after treatment was significantly greater in patients who received either rizatriptan 5 or 10 mg compared to those who received placebo. In a separate study, doses of 2.5 mg were not different from placebo. Doses greater than 10 mg were associated with an increased incidence of adverse effects. The results from the four controlled studies are summarized in Table 2.
Study | Placebo | Rizatriptan Benzoate Tablets 5 mg | Rizatriptan Benzoate Tablets 10 mg |
1 | 35% (n = 304) | 62%* (n = 458) | 71%*,† (n = 456) |
2‡ | 37% (n = 82) | — | 77%* (n = 320) |
3 | 23% (n = 80) | 63%* (n = 352) | — |
4 | 40% (n = 159) | 60%* (n = 164) | 67%* (n = 385) |
Comparisons of drug performance based upon results obtained in different clinical trials may not be reliable. Because studies are conducted at different times, with different samples of patients, by different investigators, employing different criteria and/or different interpretations of the same criteria, under different conditions (dose, dosing regimen, etc.), quantitative estimates of treatment response and the timing of response may be expected to vary considerably from study to study.
The estimated probability of achieving an initial headache response within 2 hours following treatment in pooled Studies 1, 2, 3, and 4 is depicted in Figure 1.
Figure 1: Estimated Probability of Achieving an Initial Headache Response by 2 Hours in Pooled Studies 1, 2, 3, and 4††
††Figure 1 shows the Kaplan-Meier plot of the probability over time of obtaining headache response (no or mild pain) following treatment with rizatriptan benzoate or placebo. The averages displayed are based on pooled data from 4 placebo-controlled, outpatient trials providing evidence of efficacy (Studies 1, 2, 3, and 4). Patients taking additional treatment or not achieving headache response prior to 2 hours were censored at 2 hours.
For patients with migraine-associated photophobia, phonophobia, and nausea at baseline, there was a decreased incidence of these symptoms following administration of rizatriptan benzoate compared to placebo.
Two to 24 hours following the initial dose of study treatment, patients were allowed to use additional treatment for pain response in the form of a second dose of study treatment or other medication. The estimated probability of patients taking a second dose or other medication for migraine over the 24 hours following the initial dose of study treatment is summarized in Figure 2.
Figure 2: Estimated Probability of Patients Taking a Second Dose of Rizatriptan Benzoate Tablets or Other Medication for Migraines Over the 24 Hours Following the Initial Dose of Study Treatment in Pooled Studies 1, 2, 3, and 4†††
††† This Kaplan-Meier plot is based on data obtained in 4 placebo-controlled outpatient clinical trials (Studies 1, 2, 3, and 4). Patients not using additional treatments were censored at 24 hours. The plot includes both patients who had headache response at 2 hours and those who had no response to the initial dose. Remedication was not allowed within 2 hours post-dose.
Efficacy was unaffected by the presence of aura; by the gender, or age of the patient; or by concomitant use of common migraine prophylactic drugs (e.g., beta-blockers, calcium channel blockers, tricyclic antidepressants) or oral contraceptives. In two additional similar studies, efficacy was unaffected by relationship to menses. There were insufficient data to assess the impact of race on efficacy.
14.2 Pediatric Patients 6 to 17 Years of Age
Information contained in a clinical study relating to the efficacy of rizatriptan benzoate orally disintegrating tablets in pediatric patients (6 to 17 years old) is approved for Merck & Co., Inc.'s Rizatriptan Benzoate Tablets. However, due to Merck & Co., Inc.'s marketing exclusivity rights, this drug product is not labeled with that information.
Rizatriptan benzoate tablets are supplied as follows:
5 mg (base) – white to off-white, capsule-shaped tablets, one side of the tablet debossed with the number "93", the other side debossed with the number "7471", in unit dose boxes of 18 (6x3).
10 mg (base) – white to off-white, capsule-shaped tablets, one side of the tablet debossed with the number "93", the other side debossed with the number "7472", in unit dose boxes of 18 (6x3).
Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].
See FDA-Approved Patient Labeling (Patient Information).
Risk of Myocardial Ischemia and/or Infarction, Prinzmetal's Angina, Other Vasospasm-related Events, and Cerebrovascular Events
Inform patients that rizatriptan benzoate tablets may cause serious cardiovascular side effects such as myocardial infarction or stroke. Although serious cardiovascular events can occur without warning symptoms, patients should be alert for the signs and symptoms of chest pain, shortness of breath, weakness, slurring of speech, and should ask for medical advice when observing any indicative sign or symptoms. Patients should be apprised of the importance of this follow-up [see Warnings and Precautions (5.1, 5.2, 5.4, 5.5)].
Serotonin Syndrome
Patients should be cautioned about the risk of serotonin syndrome with the use of rizatriptan benzoate tablets or other triptans, particularly during combined use with selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs) [see Warnings and Precautions (5.7), Drug Interactions (7.4), and Clinical Pharmacology (12.3)].
Inform patients that rizatriptan benzoate tablets should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus [see Use in Specific Populations (8.1)].
Nursing Mothers
Advise patients to notify their healthcare provider if they are breastfeeding or plan to breastfeed [see Use in Specific Populations (8.3)].
Ability To Perform Complex Tasks
Since migraines or treatment with rizatriptan benzoate tablets may cause somnolence and dizziness, instruct patients to evaluate their ability to perform complex tasks during migraine attacks and after administration of rizatriptan benzoate tablets.
Medication Overuse Headache
Inform patients that use of acute migraine drugs for 10 or more days per month may lead to an exacerbation of headache, and encourage patients to record headache frequency and drug use (e.g., by keeping a headache diary) [see Warnings and Precautions (5.6)].
Manufactured In Canada By:
Toronto, Canada M1B 2K9
Manufactured For:
Sellersville, PA 18960
Rev. C 12/2012
Patient information
5 mg and 10 mg
Read this Patient Information before you start taking rizatriptan benzoate tablets and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.
What is rizatriptan benzoate?
Rizatriptan benzoate is a prescription medicine that belongs to a class of medicines called Triptans.
Rizatriptan benzoate is available as a traditional tablet and as an orally disintegrating tablet.
Rizatriptan benzoate tablets are used to treat migraine attacks with or without aura in adults.
Rizatriptan benzoate is not to be used to prevent migraine attacks.
Rizatriptan benzoate is not for the treatment of hemiplegic or basilar migraines.
It is not known if rizatriptan benzoate is safe and effective for the treatment of cluster headaches.
It is not known if rizatriptan benzoate is safe and effective in children under 6 years of age.
Who should not take rizatriptan benzoate tablets?
Do not take rizatriptan benzoate tablets if you:
- have or have had heart problems
- have or have had a stroke or a transient ischemic attack (TIA)
- have or have had blood vessel problems including ischemic bowel disease
- have uncontrolled high blood pressure
- have taken other Triptan medicines in the last 24 hours
- have taken ergot-containing medicines in the last 24 hours
- have hemiplegic or basilar migraines
- take monoamine oxidase (MAO) inhibitor or have taken a MAO inhibitor within the last 2 weeks
- are allergic to rizatriptan benzoate or any of the ingredients in rizatriptan benzoate tablets. See the end of this leaflet for a complete list of ingredients in rizatriptan benzoate tablets.
Talk to your doctor before taking this medicine if you have any of the conditions listed above or if you are not sure if you take any of these medicines.
What should I tell my doctor before taking rizatriptan benzoate tablets?
Before you take rizatriptan benzoate tablets, tell your doctor if you:
- have or have had heart problems, high blood pressure, chest pain, or shortness of breath
- have any risk factors for heart problems or blood vessel problems such as:
- high blood pressure
- high cholesterol
- smoking
- obesity
- diabetes
- family history of heart problems
- you are post menopausal
- you are a male over 40
- have kidney or liver problems
- have any other medical condition
- are pregnant or plan to become pregnant. It is not known if rizatriptan benzoate tablets will harm your unborn baby. If you become pregnant while taking rizatriptan benzoate tablets, talk to your healthcare provider.
- are breastfeeding or plan to breastfeed. It is not known if rizatriptan benzoate passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take rizatriptan benzoate tablets.
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.
Rizatriptan benzoate tablets and other medicines may affect each other causing side effects.
Rizatriptan benzoate tablets may affect the way other medicines work, and other medicines may affect how rizatriptan benzoate tablets work.
Especially tell your doctor if you take:
- propranolol containing medicines such as Inderal®, Inderal® LA, or Innopran® XL
- medicines used to treat mood disorders, including selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs).
Ask your doctor or pharmacist for a list of these medicines, if you are not sure.
Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
How should I take rizatriptan benzoate tablets?
- Take rizatriptan benzoate tablets exactly as your doctor tells you to take them.
- Your doctor will tell you how much rizatriptan benzoate to take and when to take it.
- If your headache comes back after your first rizatriptan benzoate tablet dose:
- For adults: a second dose may be taken 2 hours after the first dose. Do not take more than 30 mg of rizatriptan benzoate tablets in a 24 hour period (for example, do not take more than 3 10 mg tablets in a 24 hour period).
- If you take too much rizatriptan benzoate, call your doctor or go to the nearest hospital emergency room right away.
What should I avoid while taking rizatriptan benzoate tablets?
Rizatriptan benzoate tablets may cause dizziness, weakness, or fainting. If you have these symptoms, do not drive a car, use machinery, or do anything that needs you to be alert.
What are the possible side effects of rizatriptan benzoate tablets?
Rizatriptan benzoate tablets may cause serious side effects. Call your doctor or go to the nearest hospital emergency room right away if you think you are having any of the serious side effects of rizatriptan benzoate tablets including:
heart attack. Symptoms of a heart attack may include:
- chest discomfort in the center of your chest that lasts for more than a few minutes or that goes away and comes back
- chest discomfort that feels like uncomfortable pressure, squeezing, fullness or pain
- pain or discomfort in your arms, back, neck, jaw or stomach
- shortness of breath with or without chest discomfort
- breaking out in a cold sweat
- nausea or vomiting
- feeling lightheaded
stroke. Symptoms of a stroke may include the following sudden symptoms:
- numbness or weakness in your face, arm or leg, especially on one side of your body
- confusion, problems speaking or understanding
- problems seeing in 1 or both of your eyes
- problems walking, dizziness, loss of balance or coordination
- severe headache with no known cause
blood vessel problems. Symptoms of blood vessel problems may include:
- stomach pain
- bloody diarrhea
- vision problems
- coldness and numbness of hands and feet
serotonin syndrome. A condition called serotonin syndrome can happen when Triptan medicines such as rizatriptan benzoate tablets are taken with certain other medicines. Symptoms of serotonin syndrome may include:
- agitation
- hallucinations
- coma
- fast heartbeat
- fast changes in your blood pressure
- increased body temperature
- muscle spasm
- loss of coordination
- nausea, vomiting or diarrhea
- increased blood pressure
The most common side effects of rizatriptan benzoate tablets in adults include:
- feeling sleepy or tired
- pain or pressure in your chest or throat
- dizziness
Tell your doctor if you have any side effect that bothers you or that does not go away.
If you take rizatriptan benzoate tablets too often, this may result in you getting chronic headaches. In such cases, you should contact your doctor, as you may have to stop taking rizatriptan benzoate tablets.
These are not all the possible side effects of rizatriptan benzoate tablets. For more information, ask your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store rizatriptan benzoate tablets?
- Store rizatriptan benzoate tablets at room temperature between 20° to 25°C (68° to 77°F).
- Safely throw away medicine that is out of date or no longer needed.
Keep rizatriptan benzoate tablets and all medicines out of the reach of children.
General Information about the safe and effective use of rizatriptan benzoate tablets.
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use rizatriptan benzoate tablets for a condition for which it was not prescribed. Do not give rizatriptan benzoate tablets to other people, even if they have the same symptoms that you have. They may harm them.
This Patient Information leaflet summarizes the most important information about rizatriptan benzoate tablets. If you would like more information, talk to your doctor. You can ask your pharmacist or doctor for information about rizatriptan benzoate tablets that is written for health professionals.
For more information, call 1-888-838-2872, MEDICAL AFFAIRS.
What are the ingredients in rizatriptan benzoate tablets?
Active ingredient: rizatriptan benzoate.
Inactive ingredients: lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized corn starch, and sodium starch glycolate.
Information related to the usage of rizatriptan benzoate tablets for pediatric patients aged 6 to 17 years is approved for Merck & Co., Inc.'s Rizatriptan Benzoate Tablets. However, due to Merck & Co., Inc.'s marketing exclusivity rights, this drug product is not labeled with that information.
This Patient Information has been approved by the U.S. Food and Drug Administration.
All brand names listed are the registered trademarks of their respective owners and are not trademarks of Teva Pharmaceuticals USA.
Manufactured In Canada By:
Toronto, Canada M1B 2K9
Manufactured For:
Sellersville, PA 18960
Rev. A 12/2012
rizatriptan benzoate tablet |
rizatriptan benzoate tablet |
Labeler - Teva Pharmaceuticals USA Inc (118234421) |


text:
Poll: Should carnivals be a part of local cultural festivals?
Response | Percent | Votes | |
Yes, it's a way to get kids and families involved and they don't diminish festivals at all. | 50% | 27 | |
No, a carnival is for an event like the fair rather than a cultural festival like VikingFest. | 33% | 18 | |
None of the summer festivals or fairs need a carnival to be enjoyable. | 15% | 8 | |
total votes: 53 |
Be the first to post a comment!
Want to participate in the conversation? Become a subscriber today. Subscribers can read and comment on any story, anytime. Non-subscribers will only be able to view comments on select stories.


text:
Added to Bag!
We'll let you know if it's back in stock!
Added to Wishlist!
Hot on Your Heel
By Kelsi Dagger
Final Sale: This item cannot be returned or exchanged.
- Leather upper. Man-made sole.
- Platform measures 0.5 inches. Heel measures 2.75 inches. Adjustable straps with buckle closure.
- Imported


text:
You're reading the news with potential spoilers, make them spoiler free, dismiss
View all 127 pictures for Lee Seon-gyoon
Extended Preview Highlights | Teaser 2 | Teaser | Appraisals at Premiere |
Teaser | Official Trailer | Trailer 2 | Trailer |
To participate to HanCinema, you must sign up or log in. Sign up, Why ?
Fan club |
Quick message | |||||||||||||||||||||||||||||||
To participate to HanCinema, you must sign up or log in. Sign up, Why ?
Old message board |
Subscribe to HanCinema Pure to remove ads from the website (not for episode and movie videos) for US$2.99 per month (you can cancel anytime).
The first step is to be a member, please click here : Sign up, then a subscribe button will show up.
Today's birthdays


text:
The Mentalist Gold Cologne
By ScentStory for Men
The Mentalist Gold Cologne by ScentStory All products are original, authentic name brands . We do not sell knockoffs or imitations.
3.4 oz Eau De Toilette Spray
Item #500233
In Stock & Ready to Ship!
Hurry! Only 9 in stock
This product has 1 Out of Stock items |
0.06 oz Vial (Sample)
Item #500234
Customers Who Bought This Item Also Bought
More ScentStory fragrances
for Women: Gossip Girl Xoxo , Gossip Girl Spotted! ,for Men: 24 Gold The Fragrance Jack Bauer , 24 Platinum The Fragrance Jack Bauer , 24 The Fragrance Jack Bauer , 24 Go Dark The Fragrance Jack Bauer , The Mentalist Silver ,
See all ScentStory products
Customer Comments
You saved me from having to sneek out to get my wife a valentine present. I also want to thank you for your choice of wraping and packaging. My wife had no idea what she was getting. Thank you!
C. Rexford (Shreveport, LA)


text:
Dave Dyer
The Eagle-Tribune
---- — Nikko's new mark
Methuen's Nikko Ferrara, who set two world deadlift records earlier in the year, set another last month in a tournament. Moving up a weight division to 220 pounds, he set a record in the 20-23 age division with a deadlift of 700 pounds, 15 more than his previous best.
Shamrock entries
Entries are coming in at a rapid pace for the sixth annual Frozen Shamrock 3-Mile Run, which is set for Feb. 24 at 1 p.m. at Archie's Little River Ale House in Haverhill. With five weeks to go, there were already about 500 entries registered for the popular race, which is the first stop in the Wild Rover series. Races in Lawrence at the Claddagh and in Lowell, of four and five miles, follow on the next two Sundays.
Banner controversy?
In an effort to modernize the gymnasium, Haverhill High has replaced all of its banners with new ones. It helps make the gym fresher, but some alumni are upset that the state championship girls basketball banners, which were in reasonable condition, were taken down.
They will be replaced, said athletic director Tom O'Brien, but in a smaller form and it hasn't been decided if the names of all the players and coaches will be listed because that takes up a lot of space and is not consistent with the other banners.
The old banners will probably be auctioned off. That will accommodate several requests for them and help raise money for the athletic department.
Bias vs. softball charge
The North Reading Citizens for Equality has charged that the town and school are in violation of Title IX requirements because there is not a softball field at the high school while there is a baseball field and baseball practice field.
The girls practice and play at the Little Middle School, which is 2 1/2 miles away and doesn't offer access to locker rooms or bathrooms or have any irrigation or regular maintenance.
Moreover, a plan for a new high school/middle school includes a proposal for a new practice baseball field but no softball field. The School Committee has said it will review the charges.
Big meets in Vermont
The coach of Vermont wrestling power Mount Anthony, Scott Legacy, was intrigued by the dual-meet showdown last month between Timberlane and North Andover, which drew a boisterous crowd of over 700 fans. While Mount Anthony has no big local rival, says Legacy, it always draws good crowds of up to 500 fans and much more when wrestling powers like Danbury, Conn., come to town.
Mount Anthony will be at the Methuen Invitational Saturday.
'The loneliest number'
The Dec. 31 issue of Sports Illustrated included a terrific article on Grinnell College's Jack Taylor as well as others, in the NBA (only Wilt Chamberlin) and college, who have scored 100 points in a game. It provides an interesting perspective and gives you added respect for Taylor.
Unfortunately, one week after the article came out, Taylor broke his wrist, ending his season averaging 36 points a game.
Boys gymnastics demise
Anyone who enjoys watching boy gymnastics should take in Andover's home meet with Lowell at 7 p.m. Thursday. It may be one of your last chances because the MIAA Board of Directors voted last week to eliminate boys gymnastics as an MIAA sport. This winter will be the final season in which boys gymnastics will be an MIAA-sponsored sport.
Andover features one of the top boy gymnasts in New England in Brian Manning as well as another standout in Joseph Aronov.


text:
Who Does The Redskins' John Beck Remind You Of?
Todd Collins.
Both Beck and Collins had difficulty breaking through as starters and were reletively old as starters. If Mike Shanahan is serious about giving Beck a shot as the Washington Redskins starting quarterback, he had better hope that Beck is as good a system quarterback as Collins was in Al Saunders' offense.
Collins played 14 games for the Buffalo Bills in 1997, producing: a scant 55 percent completion rate; a 1:1 TD to INT ratio, and a 69.5 QB rating. It took ten years before Collins' had another chance to throw more than 20 pass attempts. His performance when he stepped in for an injured Jason Campbell for four games of 2007 was a revelation on two counts.
No one in Washington had any idea of what Saunders' offense could be until Collins' performance (106 QB rating). Who, other than Collins and Saunders, knew Collins had that in him? No one in Kansas City for sure. Collins never could beat out Trent Green as starter. Joe Gibbs didn't know. If Gibbs knew, he would have named Collins starter.
Collins' success rose from his deep understanding of Saunders' offense. Any number of Redskins fans misread that as talent. Collins was solid as a back up, pedestrian as a starter and awful everywhere outside of Saunders' downfield offense.
The Shanahans see Beck as an eminently coachable system quarterback who might easily beat out Rex Grossman as starter.
Collins had fewer playoff chops than Mark Brunell (from his Jaguars days) and less talent Campbell. But in 2007, when Brunell and Campbell were both on a steep learning curve for a new offense, Collins familiarity with that system was an equalizer.
I always thought Gibbs made a mistake in not giving Collins more of a chance to start. I force myself to remember that when I hear talk of John Beck starting for the Redskins this year.
Beck has no more time in Shanahan's system than Donovan McNabb. He is at least equal in talent to Grossman. Nobody on the roster is a better quarterback than McNabb. Neither is any free agent or trade target other than Vince Young. Something about that is an equalizer for Beck.
If the Shanahan and McNabb are determined to part company, then this thing with Beck should play itself out. Cannot be any worse than Todd Collins.
Speaking of Vince Young....
Football analyst Steve Wyche said on the NFL Network yesterday that Minnesota coach Leslie Frazier informed him that the Vikings had not considered adding Young to the roster. The Vikings do intend to bring in a veteran quarterback, says Wyche (emphasis mine).
Don't expect the Vikings, or anyone else, to trade for McNabb under his current contract. McNabb could help himself and the Redskins by agreeing to a renegotiated deal with a team of his choice, the Vikings, for example. Otherwise, the market for McNabb and Young will not open up until both are released.
Young to the Redskins filled the Blogosphere this week and what great sport it was. While I don't think it's a great idea, the Michael Vick experience last season taught many people not to be so dismissive. For raw talent, no one is better than Young. He will be successful in the right circumstance as was Vick with the Eagles, or Collins with the Redskins.
Washington is not the right circumstance. For one thing, Shanahan is not the Mr. Sensitivity who would mesh well with Young. For another, Vick seems to have gained something from his exposure to McNabb, who would not be around to sprinkle pixie dust on Young.
However, Bruce Allen would be derelict in his duty if he did not at least talk to Young after his release by the Titans.
Point after: Sigh! Bloggers make guesses about which story will interest most readers. A post about John Beck seemed appropriate for the week when we spent so much attention on Vince Young and the quarterback situation. My other storyline was something about Redskins draftee Roy Helu and Shanahan's knack for finding ace running backs. I should have gone with that story first. The thought of a Beck-Grossman QB competition puts even me to sleep.
The Helu story up on Monday.


text:
Published June 13, 2013, 06:00 PM
Devils Lake native new North Dakota VFW Commander
A Devils Lake veteran is now the head of the state's VFW chapter. Emery Fisher served as the vice commander before being elected the state commander for North Dakota at the beginning of the month. He will serve a one year term.By: Adam Ladwig, WDAZ


text:
Four black composite cleats are located around the boat, making tying off convenient and easy!
Click on image to EnlargeTwo Tempress seats in patterned shells come standard with the 1650 Retriever SC.
Click on image to EnlargeKeep valuables dry and protected inside the storage compartment under the raised bow platform.
Click on image to EnlargeWhen selecting the bench seat option, additional storage is available beneath the bench, keeping gear out of site, but easily accessible.
Click on image to EnlargeFor more capacity, add a Catfish 26-gallon livewell with recirculating system.
Click on image to EnlargeA spacious, lockable compartment in the bow deck keeps gear secure, stowed away and dry.
Click on image to EnlargePlease complete the form below. Soon after submission you will be contacted by a Crestliner Dealer.
SubmitPlease complete the form below. Soon after submission you will be contacted by a Crestliner Dealer.


text:
As of Friday, April 5, 2013
© Copyright 2014
Albany Herald
ALBANY, Ga. — Firefighters, responding to a report of a house fire on the 1300 block of East Society Avenue Friday morning, found a blaze started by electricity that should not have had power.
MOBILE USERS: Click here to view the video
Battalion Chief Keith Ambrose says that initial reports were that one of the apartments in the duplex at 1323 E. Society Ave. was occupied. And despite the fact that Albany Water, Gas & Light had no power flowing into the apartment where firefighters believe the fire originated, the occupant managed to use an extension cord inside the apartment, which is what firefighters think caused the fire.
"The unit had been red-tagged by WG&L, which is supposed to mean that there is no power flowing in," Chief James Carswell said. "We've notified WG&L and they're investigating it."
Upon arrival, firefighters made three searches of the apartment to ensure no one was inside before attacking the fire, which had traveled into the attic space of the concrete-block building.
Ambrose said witnesses to the fire said that the man who was living in one of the apartments was known to use a charcoal grill as a source of heat. Carswell said that after a preliminary investigation, however, the cause of the fire is believed to have been electrical in nature.
"When they cut off the power, they typically put a sleeve or boot on the prongs where the meter was, but in this case, the boot either malfunctioned or was tampered with and allowed power to the apartment," Carswell said.
RedEric 11 months, 2 weeks ago
DIY note to self. Use bigger wire on next project. Note to self...steal it.
whattheheck 11 months, 1 week ago
Dollar Tree extension cords won't run a whole house anymore. Darn Chinese!
Thurman 11 months, 2 weeks ago
"Firefighters, found a blaze started by electricity that should not have had power." What?
Sister_Ruby 11 months, 1 week ago
Key factoid: "the boot either malfunctioned or was tampered with......"
HELLO???? Want to GUESS which one it was?? The GENIUS done messed with tha PRONGS to get him some VOLTAGE and he done set THA PLACE ON FIRE!!!!!!!!!!!!!!
Any questions, morons? Why mince words? The DOPE tried to STEAL and got BURNED in the process. HEY, get in line, DOPE!!
Sign in to comment
More like this story
- Winds cause power outages across city ( June 28, 2010 )
- MEAG to raise fees ( October 28, 2010 )
- Commission to receive WG&L revenues under merger bill ( March 31, 2010 )
- Reserves at WG&L shown to be 'dangerously low' ( January 26, 2010 )
- City, WG&L sued over funds ( November 18, 2010 )


text:
June 15, 2011 – August 21, 2011
There are 840 students in the Snoqualmie School District that participate in the free or reduced breakfast and lunch program. During the school year children will receive breakfast and lunch at school. What about breakfast and lunch during the summer months? Currently, there is not a children's lunch program in the Snoqualmie Valley. In order to fill the gap and ease families concerns we started a new program called Summer Cupboard. This program will assist families that have children enrolled in the free or reduced lunch program in the Snoqualmie Valley School District.


text:
change text size
You are here:
Sort by price (high to low)
The discomforting reality of surviving in a war-zone is pieced together through fragments of letters from Aida, a resident of Sarajevo. Far away, someone endures the anguish of... more
Product code: 22149603
A young couple with struggling careers and serious issues with conceiving play out their own troubles through the dogs their raise to fight to the death.
Product code: 22149102
Product code: 22149103
Seven erotic tales of sensuous fantasy, taken from "Little Birds".
Product code: 536591
A collection of very short stories from a range of genres chosen to interest and appeal to students at Key Stage 3. Some of the stories are written by well-known authors, such as... more
Product code: 21442001
When MCC Berkshire moves into Ailsa and her mother's antiques shop, he turns their lives upside down. He sleeps on the old bed in the shop and corners every potential customer with... more
Product code: 22118103
Product code: 22118102
Twelve short stories with locations as far apart as London and New York, Mexico and Nigeria. In " The Luncheon" a young man learns the dangers of taking out someone who "enjoys a... more
Product code: 22078302
These short stories present the reader with a modern China, facing up to a complex history of repression and guilt. From the bustling heart of Beijing and the barren expanse of... more
Product code: 21222601
'Love day' features a young man in an invasion fleet in World War II who remembers the role his father played in building one of the ships. In 'Shadrach' a child recalls what... more
Product code: 21849802
Back to All fiction books
0 items


text:
There are no items in your bag. Click here to visit our store.
Post: 313
Join Date: May 2010
Post: 34
Join Date: Apr 2012
this dude is a SCAM.. watch out!!
Post: 284
Join Date: Dec 2011
Location: ( ͡° ͜ʖ ͡°)
this dude is a SCAM.. watch out!!why are you trolling browhy are you scamming him bro
scamming who? who are you guys? LOL


text:
African Americans
New report shows that while African Americans make up less than 14 percent of the U.S. population, they bear over 30 percent of the costs of Alzheimer's disease.
About Us
Who We Are
The African American Network Against Alzheimer's will unify the powerful voice of the African American community on the issue of Alzheimer's disease. We will arm African Americans and others who are committed to our mission with the information and easy-to-use connections needed to be heard by the public, in Washington and in state capitals, and by industry leaders and the research community. Our goal is to engage and connect a network of individuals, businesses, and nonprofit organizations to mobilize the energy of African Americans in advocacy efforts that advance our national commitment to ending Alzheimer's.
Despite there being 5 million victims of Alzheimer's in the U.S., most Americans aren't aware of the extent and impact of the disease and that African Americans are twice as likely to develop Alzheimer's as others.
Share Your Story
Your voice helps bring Alzheimer's out of the shadows.
Join our community of Story Tellers united in their determination to stop Alzheimer's! Share your personal story, a photo of a loved one, or a video telling us about your experience.
Together, we can show our leaders in Washington and beyond why we must make finding a cure for Alzheimer's a national priority!
Stop Alz
No organization is going to stop Alzheimer's. What will stop Alzheimer's is the will of the American people. Act now.


text:
The Improbability of the 'Complete Rider'
November 15, 2011 by George Tamayo
Filed under Body
Over the weekend, Andrew Hood of VeloNews posited that the upcoming year could be the one for Fabian Cancellara to win the Tour de France. Hood's logic is that with the emphasis on the individual time trial and the de-emphasis of summit finishes, Cancellara, the best time trialist of our generation (ever?), who can be a fairly effective climber, could, in the fashion of Miguel Indurain, vanquish a Grande Boucle of the kind we shall see in 2012. Of course, being teammates to the brothers Schleck makes this line of reasoning a non-starter; however, Hood is not the only one who thinks that Cancellara could contend for the final malliot jaune.
For what little it's worth, I wholly agree with Mr. Hood's assessment and nominate Cancellara as the most compete rider of the last 10 years, may be more.
He can win on most any terrain and type of race. The diversity of his wins is unmatched by any rider in the current pro peloton. His time trial ability is unquestionable, despite Tony Martin having the upper hand this year. He can win one-day classics on cobbles and gravel (Roubaix, Flanders, E3, Eroica). He can win where sprinters typically prevail (Milan-San Remo, flat Tour stages), and in 2011, nearly beat the sprinters on their own terms with a second at MSR, a fourth (third??) at this year's Copenhagen Worlds, and fourth on the Champs Elysee. He can win in the one week stage races with significant climbing (Tour de Suisse, Tirreno-Adriatico).
On Monday, Bernard Hinault celebrated his 57th birthday, and Cyclingnews paid tribute by asking if "The Badger" was the greatest of them all. Hinault is the last rider to win in a Grand Tour, a Cobbled Classic, an Ardennes Classic and a World Championship, laying the foundation for his claim to greatness. It also makes him the last of the complete riders, who could ride, and win, from late winter through the spring and summer into the fall in any kind of race.
Arguably, only Cancellara has come closest to matching Hinault's swath of victories, and even he falls well short, at least so far. Why is it that in the past 25 years since Hinault's retirement no other rider has been able to truly take on the complete rider mantle?
The answer may lie in a strange irony. Fitness.
Specifically, the idea that today's pro cyclist is a fitter, stronger, more precisely honed machine than ever before.
When Francesco Moser took on the Hour record in 1984 he opened the flood gates to whole new method of scientific based training that was elevated by Greg LeMond and made the indispensable standard by Lance Armstrong. Riders today, and not just the pros, but even we weekend warriors, can train to such specific peaks in ultimate fitness so as to time them for pre-determined goals. To be competitive at any race on the calendar requires riders to be within one of their peak fitness windows.
The science behind this training also tells us that humans can only achieve these sustained performance peaks for a few weeks at time only two, may be three times a year at most.
While sports medicine was around in Hinault's day, it was rudimentary by today's standard. It would be fascinating to look back and know whether Hinault and his cohorts raced in a perpetual state of over training or under training. Ignorance being bliss, they raced on for nine months of the year simply because they had no reason to do otherwise.
Today, Cancellara and every other rider in the pro peloton, knows from the outset that defining specific goals necessarily requires sacrificing others. With riders so specialized in a particular style of racing, the odds simply don't encourage Cancellara to sacrifice the spring for the summer.
Much ballyhoo has been made on both sides of the argument for and against banning radios to improve racing. But, if what we yearn for is a return to the halcyon days of the complete rider, then instead of banning radios, we should ban practitioners of sports medicine, nutritionists, physiotherapists and osteopaths, along with power meters, heart rate monitors and the rest.
Or, we can simply accept progress for what it is and revel in the moment that we are in, and look forward to what the future has in store, while we recall the greatness of what once was.
Image: John Pierce, Photosport International


text:
Our Video Picks
Terror probe launched over missing plane
Malaysia has launched a terror probe into the disappearance of a passenger jet carrying 239 people.
09 March 2014 4:17 Sky News
Watch videoMalaysian jet's disappearance raises questions about foul play
Two passengers aboard the missing Malaysia Airlines plane may have been travelling under stolen passports, raising questions of foul play in one of the rarest of aviation disasters. Gavino Garay reports.
10 March 2014 1:32 Reuters
Watch videoSix Aussies in missing plane
The search for Malaysian Airlines jet continues as six Australian passengers were named by DFAT. Courtesy Channel Ten
09 March 2014 1:16 news.com.au
Watch videoBrisbane couples on missing flight
Two Brisbane couples and another two Australians are among 239 people missing on a Malaysia Airlines flight.
08 March 2014 1:47 Sky News
Watch videoPutin calls back troops from drills
Putin has told troops to return to their bases after calling a snap drill to check their battle-readiness.
04 March 2014 5:54 Sky News
Watch videoHissed off
Watch what happens when this deadly eastern brown snake gets cornered in a Brisbane home. Courtesy Snake Catchers Brisbane, Ipswich, Gold Coast & Toowoomba
16 January 2014 0:57 Courier Mail
Watch videoNuns held by Syrian rebels arrive in Damascus
New amateur video shows Syrian nuns being released by their captors after being held for three months. Meanwhile, the nuns return to Damascus. Nathan Frandino reports.
11 March 2014 1:31 Reuters
Watch videoU.S. Ambassador to Ukraine: Discussion "over" on Crimea's future
The U.S. Ambassador to Ukraine says Crimea should remain part of Ukraine and commends Ukraine's acting government for resisting provocations. Deborah Lutterbeck reports.
11 March 2014 1:24 Reuters
Watch videoCounseling Families of Malaysia Airlines Flight MH370
At the Metropark Lido Hotel in Beijing, relatives of Malaysia Airlines flight MH370 passengers have convened for answers. A non-profit organization Compassion Relief Tzu-Chi Foundation arrived at the hotel Sunday to counsel families through their tension
11 March 2014 1:59 WSJ Live
Watch videoVolunteers Counsel Families of Passengers
At the Metropark Lido Hotel in Beijing, relatives of Malaysia Airlines flight MH370 passengers have convened for answers. A non-profit organization Compassion Relief Tzu-Chi Foundation arrived at the hotel Sunday to counsel families through their tension
11 March 2014 1:59 WSJ Live
Watch videoMeet Mexico City's newest resident
The Chapultepec Zoo celebrates the birth of a baby hippo. Alicia Powell reports.
11 March 2014 1:28 Reuters
Watch videoRussians rally in Moscow to support annexation of Crimea
Russian supporters of their country's annexation of Crimea rally in Moscow with one saying, "terrorists took over power in Kiev" Nathan Frandino reports.
11 March 2014 0:48 Reuters
Watch videoSearch Continues for Missing Jet, and More
What's News: Authorities race for clues to the fate of a missing Malaysia Airlines jet. The Federal Reserve may have to accelerate the pace of tapering. EBay rejects Carl Icahn's board nominees. Veronica Dagher reports. Photo: AP
11 March 2014 1:29 WSJ Live
Watch videoJudge bans broadcast of postmortem evidence in Pistorius trial
Day six of the Oscar Pistorius murder trial begins with the judge banning the live broadcast of postmortem evidence of Reeva Steenkamp's death. Nathan Frandino reports.
11 March 2014 1:26 Reuters
Watch videoNine News - Super Stadium
Perth's new stadium is about to undertake a new phase.
11 March 2014 2:43 news.com.au
Watch videoOil slick off Malaysia not from plane
Lab analysis has shown that samples from an oil slick found off Malaysia are not from the missing jet.
10 March 2014 2:46 Sky News
Watch videoEurope Considering Increasing U.S. Gas Imports
European leaders are starting to discuss importing more natural gas from the U.S. following Russia's military intervention in Crimea, a sign that Russia is facing long-term economic consequences for its actions in Ukraine. Liam Denning reports. Photo: AP.
10 March 2014 4:05 WSJ Live
Watch videoChina urges Malaysia to speed up plane search
China urged Malaysia to step up the search for a Malaysia Airlines jetliner that went missing with 239 people on board and says it has sent security agents two help with an investigation into the misuse of passports.Sarah Toms reports.
10 March 2014 1:35 Reuters
Watch videoHughes 'exposed himself on set'
A court has heard that Hey Dad! Star Robert Hughes was described as a 'dirty old man' by a cast member.
10 March 2014 0:33 Sky News
Watch videoDebris Sighting Is a Cold Lead in Search for MH370
A search operation spotted suspected fragments of the missing Malaysia Airlines flight MH370, but they haven?t been recovered. The search continues, Deborah Kan reports, but there's still no sign of the aircraft.
10 March 2014 2:24 WSJ Live
Watch videoFamilies of passengers on board missing flight wait for news
The families of passengers of a Malaysia Airlines flight that disappeared over the sea near Vietnam wait for news and prepare to travel to Kuala Lumpur. Sarah Toms reports.
10 March 2014 1:38 Reuters
Watch videoMick Fanning through to final 12 at Snapper Rocks
Mick Fanning has survived a tough third round against American wildcard Dane Reynolds, progressing through to the final 12 at Snapper Rocks.
10 March 2014 0:59 Fox Sports
Watch videoPistorius trial moves into second week
A security guard continues to testify at Oscar Pistorius' murder trial as it heads into its second week.
10 March 2014 0:39 Sky News
Watch videoMalaysia to probe 'life raft' sighting
Malaysia has dispatched ships to investigate a floating object that could be a missing airliner's life raft.
10 March 2014 2:02 Sky News
Watch videoMalaysia to probe 'life raft' sighting
Malaysia has dispatched ships to investigate a floating object that could be a missing airliner's life raft.
10 March 2014 2:02 Sky News
Watch video