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Emerging Infectious Disease ISSN: 1080-6059
Volume 10, Number 2—February 2004
2004 SARS Edition
Laboratory Study
Interferon-β 1a and SARS Coronavirus Replication
Article Contents
Suggested citation for this article
A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive effort is under way to identify and test promising antiviral drugs. Here, we report that recombinant human interferon (IFN)-β 1a potently inhibits SARS coronavirus replication in vitro.
The recent global outbreak of severe acute respiratory syndrome (SARS) has quickly gained notoriety as a newly emerging infectious disease. The etiologic agent was identified as a coronavirus (SARS-CoV) that is not closely related to any of the previously characterized coronaviruses (1,2). As of September 26, 2003, a total of 8,098 probable cases of SARS have occurred with 774 deaths.
No antiviral treatments are currently available against SARS-CoV. SARS cases have been treated symptomatically according to the severity of the illness. A treatment protocol consisting of antibacterial agents and a combination of ribavirin and methylprednisolone was recently proposed. However, the therapeutic value of ribavirin remains uncertain because it has no activity against SARS-CoV in vitro. Molecular modeling studies suggest that rhinovirus 3Cpro inhibitors may be useful for SARS therapy, but results of recent in vitro testing of the lead molecule, AG7088, were negative (3).
Previous studies showed that some coronaviruses, including avian infectious bronchitis virus, murine hepatitis virus, and human coronavirus 229E, are susceptible to type I interferons in vitro or in vivo (4–7). Therefore, we evaluated the in vitro efficacy of a recombinant human type I interferon (IFN), IFN-β 1a (Serono International, Geneva, Switzerland) against three different isolates of SARS-CoV (Tor2 and Tor7 and Urbani) using yield reduction assays. The IFN-β 1a preparation employed in this study was selected because it is currently used as part of the most effective treatment regimen for relapsing forms of multiple sclerosis (8), and more importantly, because it was shown to have antiviral activity (as measured in a vesicular stomatitis virus cytopathic assay system) 14 times greater than the currently available treatment using IFN-β 1b (9).
In the current study, Vero E-6 cells were treated with concentrations (5,000 to 500,000 IU/mL) of IFN-β 1a either 24 h before or 1 h after inoculation with the SARS-CoV (m.o.i. 0.1 PFU/cell), and monitored for cytopathic effect and production of infectious SARS-CoV at 24, 48, and 72 h postinfection. Inhibition of the SARS-CoVs by IFN-β 1a was dependent on both time of drug administration and time of culture sampling after SARS-CoV infection. Production of infectious SARS-CoV was potently inhibited (≥99.5% or 2.00 log10 PFU/mL) at 24 h postinfection. by pretreatment of Vero E-6 cells with IFN-β 1a at all concentrations tested (Figure 1). By 72 h postinfection, inhibition of SARS-CoV production by IFN-β 1a had declined for all three SARS-CoVs, with inhibition (>70%) being detected in the Tor7 (Figure 1) and Urbani isolates (data not shown). IFN-β 1a was somewhat less effective at inhibiting SARS-CoV replication when employed after infection of cultures (Figure 1). Nonetheless, production of infectious SARS-CoVs was considerably reduced (≥90% or 1.00 log10 PFU/mL) at 24 and 48 h postinfection. Protection of Vero E-6 monolayers against SARS-CoV–induced cytopathic effects by preinfection or postinfection treatment with IFN-β 1a was dramatic, even at 72 h postinfection (Figure 2). Additional concentrations of IFN-β 1a (0.5–5,000 IU/mL) were tested to determine the 50% inhibitory concentration (IC50). Pretreatment of Vero E-6 cells with concentrations as low as 50 IU/mL, or posttreatment of cells with concentrations at 500 IU/mL, provided a 50% reduction with the Tor2 isolate at 24 h postinfection.
Faced with a burgeoning epidemic of SARS cases and a lack of effective treatment options, identifying compounds with antiviral activity that could be potential therapeutics has become a high priority. Our report suggests that IFN-β 1a may be effective as a treatment for SARS-CoV infections. As noted above, IFN-β 1a is currently being used for a variety of clinical indications, including multiple sclerosis, and has shown dose-dependent efficacy in several clinical trials. Importantly, IFN-β 1a exhibited potent antiviral activity at doses that have already been shown to have acceptable safety profiles in animals (10). Thus, we report the identification of a compound that may be suitable for rapid development as a treatment for SARS-CoV infection.
Dr. Hensley is a staff microbiologist in the Virology Division, United States Army Medical Research Institute of Infections Diseases. She specializes in the pathogenesis and immunobiology of high-hazard virus infections in animal models for vaccine and antiviral drug development.
We thank Dr. Heinz Feldman for his kind provision of Tor2 and Tor7 isolates.
This study was supported, in part, by NIH grant R21 AI053539.
- Peiris JSM, Lai ST, Poon LLM, Guan Y, Yam LY, Lim W, Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361:1319–25. DOIPubMed
- Marra MA, Jones SJM, Astell CR, Holt RA, Brooks-Wilson A, Butterfield YS, The genome sequence of the SARS-associated coronavirus. Science. 2003;300:1399–404. DOIPubMed
- Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science. 2003;300:1763–7. DOIPubMed
- Sperber SJ, Hayden FG. Comparative susceptibility of respiratory viruses to recombinant interferons-alpha 2b and -beta. J Interferon Res. 1989;9:285–93.PubMed
- Pei J, Sekellick MJ, Marcus PI, Choi IS, Collisson EW. Chicken interferon type I inhibits infectious bronchitis virus replication and associated respiratory illness. J Interferon Cytokine Res. 2001;21:1071–7. DOIPubMed
- Vassao RC, de Franco MT, Hartz D, Modolell M, Sippel AE, Pereira CA. Down-regulation of Bgp1(a) viral receptor by interferon-gamma is related to the antiviral state and resistance to mouse hepatitis virus 3 infection. Virology. 2000;274:278–83. DOIPubMed
- Minagawa H, Takenaka A, Mohri S, Mori R. Protective effect of recombinant murine interferon beta against mouse hepatitis virus infection. Antiviral Res. 1987;8:85–95. DOIPubMed
- Panitch H, Goodin DS, Francis G, Chang P, Coyle PK, O'Connor P, Randomized, comparative study of interferon beta-1a treatment regimens in MS: The EVIDENCE trial. Neurology. 2002;59:1496–506.PubMed
- Antonetti F, Finocchiaro O, Mascia M, Terlizzese MG, Jaber A. A comparison of the biologic activity of two recombinant IFN-beta preparations used in the treatment of relapsing-remitting multiple sclerosis. J Interferon Cytokine Res. 2002;22:1181–4. DOIPubMed
- Mager DE, Neuteboom B, Efthymiopoulos C, Munafo A, Jusko WJ. Receptor-mediated pharmacokinetics and pharmacodynamics of interferon-{beta}1a following intravenous and subcutaneous dosing in monkeys. J Pharmacol Exp Ther. 2003;306:262–70. DOIPubMed
Suggested citation for this article: Hensley LE, Fritz EA, Jahrling PB, Karp CL, Huggins JW, Geisbert TW. Interferon-ß 1a and SARS coronavirus replication. Emerg Infect Dis [serial online] 2004 Feb [date cited]. Available from: URL: http://wwwnc.cdc.gov/eid/article/10/2/03-0482.htm
Comments to the Authors
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CHOC Docs
Bassam S Younes, MD
Office and Contact Information
CHOC Children's Specialists
1201 W La Veta
Orange, CA 92868
phone: (714) 509-4099
fax: (714) 509-4299
map & directions
Physician / Researcher Bio
Bassam Younes, M.D. has worked at CHOC Children's since 2001. He earned his medical degree from Semmelweis University School of Medicine in Budapest, Hungary. He did his internship at Apathy Memorial Hospital in Budapest and his residency at Semmelweis University School of Medicine's Pediatric Hospital. Once in the United States, he did a residency at Maimonides Medical Center in New York where he was also pediatric chief resident. He did his fellowship in pediatric gastroenterology, hepatology, and nutrition at the University of California, Los Angeles Children's Hospital. He is a board certified pediatrician and gastroenterologist.Research
Dr. Younes is dedicated to treating and researching all gastrointestinal disorders. Among his current projects, Dr. Younes is currently coinvestigator in several multi-center studies evaluating the efficacy and safety of new drug treatments for pediatric patients with Crohn's disease. He is also involved with a study evaluating inter acid treatment for inflammatory bowl disease and CHOC's research on anti-Interleukin 5 therapy for the treatment of eosinophilic esophagitis. In the future, he is very interested in doing further research on the treatment of pediatric liver disease.Education
- Medical School
Semmelweis University School of Medicine, Budapest, Hungary - Internship
Apathy Memorial Hospital, Budapest, Hungary - Residency
Semmelweis University School of Medicine - Pediatrics
Maimonides Medical Center, Brooklyn, New York - Pediatrics
Maimonides Medical Center, Brooklyn, New York - Pediatric Chief Resident - Fellowship
Pediatric Gastroenterology Hepatology & Nutrition
UCLA Children's Hospital, Los Angeles, CA
Board Certifications
- California Board Certified Physician
Honors and Awards
- Orange County Medical Association's Physicians of Excellence 2012
News |
More than 80 CHOC Children's Doctors Named "Physicians of Excellence" January 03, 2012 More than 80 CHOC Children's physicians, including specialists and pediatricians, are named "Physicians of Excellence" by the Orange County Medical Association.... |
Published Works
B.S.Younes, M. E.Ament, S. V. McDiarmid et al The Involvement of the Gastrointestinal Tract in Posttransplant Lymphoproliferative Disease in Pediatric Liver Transplantation.
J Pediatr Gastroenterol Nutr, Vol.28,No.4, April 1999.
B.S. Younes,S.V. McDiarmid, M.G.Martin et al The Effect of Immunosuppression on Posttransplant Lymphoproliferative Disease in Pediatric Liver Transplant Patients
Transplantation Vol.70,94-99, No.1, July 15, 2000

subset: commoncrawl


text:
In which we discuss fit, proportion and what a good tailor can and can't do for you. (Fair warning: You have a big reading list to get to.)
In which we learn how to pinpoint exactly what your signature style actually is or what you want it to be. (There's no homework this time, but there may be a pop quiz.)
In which we begin by taking a peek into how some xoJaners would describe their own signature looks. Plus: YOU HAVE HOMEWORK!


text:
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The Laugh Inn is closed until further notice.
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I went on Friday 21st November to see the Gutterband, the night was brilliant, good club band were fantastic drinks were cheap and doorstaff were polite, i,m going to see Chubby Brown there in December. Karen
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Download 2012 Melexis Quality Certificates
Download Melexis Melexis Annual Report 2012
Electric Motor developments, Magnetic simulation and measurements, Motor Design, Rapid prototyping towards 1st motor samples, Test environments for electric motors.
Pure consulting as well as full system developments.
Mechatronics integration, Electronics development in HW and SW, HW and SW consulting service as well as developments based on Melexis motor controllers: MLX81200/01, MLX81205/07/10/15, MLX80251, MLX81100, MLX81150, MLX80151.
In the field of BLDC motor control for: Classic BLDC motors, Switched Reluctance (SR-Motors).
Melexis and driveXpert sponsor a team of the World Econ Move race in Japan with a new BLDC motor and drive electronics,
May 3, 2012 Next generation automotive BLDC motor drivers from Melexis bring LIN-ready single chip solution for BLDC motors and actuators


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SHAREHOLDER ALERT: Levi & Korsinsky, LLP Announces Investigation Into Possible Breaches Of Fiduciary Duty By The Board Of Berry Petroleum Co. In Connection With The Sale Of The Company To Linn Energy LLC Affiliate
Levi & Korsinsky is investigating the Board of Directors of Berry Petroleum Co. ("Berry" or the "Company") (NYSE: BRY) for possible breaches of fiduciary duty and other violations of state law in connection with the sale of the Company to an affiliate of Linn Energy LLC ("Linn") (NasdaqGS: LINE).
Click here to learn how to join the action: http://zlk.9nl.com/berry-petroleum-bry/, or call: 877-363-5972. There is no cost or obligation to you.
Under the terms of the transaction, Berry shareholders will receive 1.25 shares of LinnCo, LLC (Nasdaq: LNCO) stock for each share of Berry stock they own, representing a value of approximately $46.24 per share. The transaction has a total approximate value of $4.3 billion, including the assumption of debt. Upon completion of the merger, LinnCo will contribute the Berry assets to Linn in exchange for Linn units. The investigation concerns whether the Berry Board of Directors breached their fiduciary duties to stockholders by failing to adequately shop the Company before entering into this transaction. At least one analyst set a price target for Berry stock at $50.00 per share.
If you own common stock in Berry and wish to obtain additional information, please contact Joseph E. Levi, Esq. either via email at email@example.com or by telephone at (212) 363-7500, toll-free: (877) 363-5972, or http://zlk.9nl.com/berry-petroleum-bry/.
Levi & Korsinsky is a national firm with offices in New York, New Jersey, and Washington D.C. The firm has extensive expertise in prosecuting securities litigation involving financial fraud, representing investors throughout the nation in securities and shareholder lawsuits. The attorneys at Levi & Korsinsky have been appointed by numerous courts throughout the country to serve as lead counsel on behalf of shareholders in major securities lawsuits and have successfully recovered multimillion-dollar damages awards on behalf of investors. For more information, please feel free to contact any of the attorneys listed below. Attorney advertising. Prior results do not guarantee similar outcomes.Select the service that is right for you!
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Cyber security webcast available online
A truly interactive discussion with two security experts yields useful pointers for system owners.
One of the difficult elements of our webcasts is that they don't tend to be as interactive as we'd like due to technical limitations. When presenters are calling in from various locations, they can't see each other and interaction is difficult. That's why the cyber security discussion broadcast last week is different than most. All three of us were sitting around the same table where we were able to see each other and discuss these questions as appropriate.
This webcast discusses the results of the cyber security survey, but the discussion goes on to consider what the answers imply from a technical or procedural standpoint. Matt Luallen and Tim Conway move into suggestions for what users can do to remediate some of the issues that emerge in the questions. The Q&A discussion also touches on many questions from registrants.
If you listened to the original broadcast, there were some noisy phone line problems, particularly near the beginning, so if you didn't hear everything as you wanted to, the sound quality on the recorded version is much cleaner.
Watch the cyber security webcast
SANS Institute
Read other articles and videos from Matt Luallen and Tim Conway:
Cyber security: Understanding spear phishing and defense techniques
The dark side of mobility
Cyber security vulnerability assessment
Cyber security advice from the field
Working in the cyber security red zone
Integrator Guide
Search the online Automation Integrator Guide |
Visit the System Integrators page to view past winners of Control Engineering's System Integrator of the Year Award and learn how to enter the competition. You will also find more information on system integrators and Control System Integrators Association.
Case Study Database
Get more exposure for your case study by uploading it to the Control Engineering case study database, where end-users can identify relevant solutions and explore what the experts are doing to effectively implement a variety of technology and productivity related projects.
These case studies provide examples of how knowledgeable solution providers have used technology, processes and people to create effective and successful implementations in real-world situations. Case studies can be completed by filling out a simple online form where you can outline the project title, abstract, and full story in 1500 words or less; upload photos, videos and a logo.
Click here to visit the Case Study Database and upload your case study.


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What makes the baby corn fancy? Those straw mushrooms don't look very broken? #imponderables
Hello! I grew up in Los Angeles, went to school in San Diego, and landed in New York City after graduation - now I happily call Brooklyn home. You can contact me via email or Tumblr Ask. Here are some previously answered Asks. some helpful tags this is me, new york city, brooklyn, blip, music, superlounge, LOL, running


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Important Info About Your Account We're sorry. We cannot find a valid password which matches the E-mail address you've provided.
PI by Givenchy for Men Mini EDT .17 oz
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Men's Black-Ruthenium Plated Curb-Link Chain Bracelet 9"
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S.T. Dupont for men is a refined and masculine fragrance. It opens with a delicate blend of spices and woody. An essential accessory to one's fragrance collection.


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recipe reviews for:
"This cranberry relish recipe features apples, grapes, pineapple, and pecans."
My Profile | Cooks I Like Reviews | Photos | Recipes | Menus | Blog
Everything you need to party like a leprechaun.
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Delicious recipes, party ideas, and helpful cooking tips! Get a year of Allrecipes magazine for just $9.99!
This tart, sweet relish needs no cooking, and the liqueur packs a subtle punch.
This no-cook sauce is like a delicious seasonal fruit salad.
See how to make mango cranberry sauce with a secret kick.


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Demand for temporary/contract workers in the professional sector is expected to exceed previous records in 2012 and 2013, according to Staffing Industry Analysts' U.S. Staffing Industry Forecast.
Specifically, the IT Staffing and Engineering/Design industry segments within the Professional/Specialty sector are expected to beat previous records for staffing revenue. IT Staffing's revenue previously peaked in 2000. This year, the industry is expected to generate 107% of 2000's revenue by the end of this year and 116% in 2013. In 2012, Engineering/Design is expected to bring in 106% of the revenue from its previous peak year of 2008 and 111% in 2013.
Meanwhile, the usage of "temps" in the office/clerical industry appears to be declining. It is projected that in 2012, the industry will only hit 85% of its previous 2006 peak and only 89% in 2013.
This correlates with what Top Echelon® Contracting has been experiencing. Engineering and IT have landed in our top three industries for contract placements for the past several years, and we are expecting the same for 2012. We have particularly seen an increase in the engineering/manufacturing sector and have begun accepting more placements in this area.
So what does this mean to you as a recruiter? Well first of all, if you are looking for a niche in which to offer contract staffing services, it's pretty clear that IT and Engineering are good places to start and have longevity.
Debbie Fledderjohann is the President of Top Echelon Contracting, Inc.
Views: 124
Tags: Contract, Engineering, Hiring, Information, Staffing, Technology
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Find People
Search NSCL:
Main Menu
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Performing an Experiment
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NSCL Users/FRIB Users Organization
Assistance to Experimenters
› Assistance to Experimenters
NSCL offers technical assistance compatible with Lab resources to users, for mechanical, electronic, and data acquisition needs when preparing for their experiments. All requests for technical assistance are initiated by the users submitting the form "
Questionnaire for Scheduling Experiments
." The NSCL provides information and design assistance to the extent that is compatible with its resources.
Prior to their arrival at the NSCL, users receive a 5-page document entitled "Responsibilities of Experimenters at NSCL". A copy of this document can be found
as well. The focus of this document is on the procedures that are to be followed just prior to, during, and just after the performance of the experiment. This helps both the users and the NSCL staff by communicating expectations from both sides.
When an experiment is scheduled, a member of the A1900 group is assigned as "A1900 Contact" to coordinate the planning of beam delivery. This contact person discusses with the spokesperson of the experiment the detailed secondary beam sequence plan and A1900 configuration. During the experiment, the A1900 group provides sustainable coverage of up to 16 hours/day on weekdays for full beam delivery support and on-call support in the event of facility breakdowns on nights and weekends.
For experiments using the supported major experimental devices (the
A1900 fragment separator
, the
S800 spectrograph
, the
Segmented germanium array
and the
Sweeper magnet
), the NSCL provides Device Physicists who tune the devices and make sure they operate properly. The Device Physicists also provide readout and analysis software for these devices. For non-supported devices, the NSCL provides contact persons who are knowledgeable about the devices and can be approached for assistance.
During the experiment, Data-U displays show a summary of the running conditions, for informing the users and for getting their immediate feedback.
Interaction between experimenters and NSCL Operations staff is facilitated by two brief coordination meetings held every work day at the NSCL: a general meeting at 8 AM and a beam coordination meeting at 1:45 PM. Starting two days prior to the experiment and during the experiment, the spokesperson of the experiment or a designee participates daily in both meetings.
NSCL assists its users by helping them find convenient, low-cost accommodation in hotels, guest apartments, and dormitory rooms. We also assist users with other aspects of their travel, e.g. by arranging for car rentals and pickups (by limousine or hotel van) at Lansing and Detroit airports.
Some other facilities available to our users are:
Desks with computers and wireless hookups;
Offices for visiting graduate students and long-term visitors;
Lockers for storing personal belongings;
Access to MSU sports and exercise facilities.
Quick Links
Faculty Research Areas
Research Groups
Propose an Experiment
NSCL Users Group
LISE++ site
Scheduling and Safety Questionnaire
Request to Ship Radioactive Materials
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Closing Account
Feedback Form
Site Map


text:
Product ISBN/ID: DOWN0669
Stock Status: In Stock
This document presents an architectural model for interconnecting automation system elements over untrusted backhaul networks. The focus is on wireless physical layer but is not limited to wireless.
- Downloadable files require Adobe Acrobat Reader.
All contents copyright of ISA © 1995-2014 All rights reserved.


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PHOTOS: The Best And Worst Dressed Stars Of The Day
PHOTOS: The Best And Worst Dressed Stars Of The Day… READ ON
PHOTOS: The Best And Worst Dressed Stars Of The Day… READ ON
PHOTOS: The Best And Worst Dressed Stars Of The Day… READ ON
It was a fashion-packed Thursday as Hollywood's hottest stars hit the streets and the red carpet, dressed in the best and worst fashions‹and RadarOnline.com has all the photos.
PHOTOS: The … READ ON
PHOTOS: Stars In Their Designer Red Dresses At The Heart Truth Fashion Show… READ ON
It was a charitably chic Wednesday evening, as stars hit the runway of the annual The Heart Truth's Red Dress Collection fashion show. RadarOnline.com has photos of all the stars… READ ON
From super skinny starlets to reality stars with swerving curves, celebrity bikini babes prove that sexy comes in all shapes and sizes. RadarOnline.com has photos of the skinniest, skurviest and… READ ON
PHOTOS: Bikini Babes! From Skinny To Skurvy To Curvy… READ ON
Fortunately for us, these sizzling stars aren't shy about stripping down into their sexy bikinis and hitting the beach with their significant others — and putting on PDA shows for… READ ON
PHOTOS: Bikini PDA! Stars Getting Busy On The Beach… READ ON
When these American beauties hit the beach in their skimpy swimsuits, they gobble up all the attention!
In honor of the Thanksgiving holiday, RadarOnline.com has compiled photos of the bikini… READ ON
Stars were in full force on Monday, hitting the red carpet in Los Angeles, NYC and even Nashville, wearing the hottest and nottest catwalk clothes and RadarOnline.com has all the… READ ON
From the swanky red carpets in NYC, Los Angeles and Miami to the streets of London, stars were dressed in the best and worst fashions on Thursday and RadarOnline.com has… READ ON
The ballots have been cast and the results are in!
PHOTOS: Bikinis! Sexy American Beauties Show Off Their Bods In Patriotic Colors
From sea to shining sea, RadarOnline.com has photos… READ ON
PHOTOS: Bikinis! Sexy American Beauties Show Off Their Bods In Patriotic Colors… READ ON
From a sexy reality show star's Sin City 30th birthday bash to the red carpet of Los Angeles Fashion Week, celebs were dressed to rock and shock over the weekend… READ ON
PHOTOS: The Best, Worst & Wackiest Fashions Of The Weekend… READ ON
From the glam-packed red carpets of international films festivals to the streets of NYC, stars were dressed in the best, worst and wackiest fashions this week and RadarOnline.com has all… READ ON
Sexy was in the air on Tuesday night, as stars stepped out to the swankiest events in scintillating style!
Katrina Bowden showed of her superior stems in drool-worthy duds at… READ ON
Leopard print never seems to go out of style, but sometimes celeb's animal instincts go a bit too wild…
Iconic designer Roberto Cavalli is one of fashion's frontrunners when it… READ ON


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Chris Brown XXL Photo Shoot; Plus More…
Chris Brown covers XXL. Check out a few pictures from his photo shoot (below). Breezy also talks about his love life, his non-beef with Drake, and his twitter issues. Read excerpts from the interview [Necole Bitchie]
Amber Rose Shows Off 28 Weeks Baby Bump [Black Celeb Kids]
Rob Kardashian Accuses Rita Ora Of Cheating With 20 Dudes [Baller Alert]
What Would Music Be Like Without Rihanna & Chris Brown [iLuLu]
Mugshot Alert! Katt Williams Arrested In Seattle [Entertainment Rundown]
Kelly Rowland Attends Solange 'True' Album Release Party [Quick's]
Similar Posts:
- I Heard It Through The Grapevine: Katt Williams, Rihanna V Breezy, Alicia Keys
- Angry Rihanna Storms Out Of UK Club For Playing Chris Brown Song
- Katt Williams Fighting Shirtless At Young Jeezy Concert
- New Music: Chris Brown "Loyal" ft. Lil Wayne & French Montana
- Rihanna & Chris Brown Reunited – Birthday Cake Remix; Plus Turn Up The Music


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Epson Stylus CX1500v Inkjet Cartridges & Supplies
new printer instead.
123Inkjets no longer carries the Epson T038025 and T039025 inkjet cartridges for the Epson Stylus CX1500v. We strive to carry the largest selection of ink and toner cartridges. Unfortunately, there are only a few Epson Stylus CX1500v printers out there, and even fewer compatible or remanufactured supplies, therefore, we no longer stock these inkjet cartridges. If you still have the Epson Stylus CX1500v printer and need inkjet cartridges, you might want to consider upgrading to a
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I just want a pin!! I hope they have a pin!!!!
When Captain Jack Sparrow sailed onto movie screens in Pirates of the Caribbean: The Curse of the Black Pearl, this dashing daredevil captured not just ships and pirate treasure, but also the imaginations of movie-goers worldwide. Now, Captain Jack is back, in Pirates of the Caribbean: Dead Mans Chest, and Master Replicas is proud to celebrate this endearing captian and his crew, with a new line of collectible prop replicas from the film. Check out the movie in theatres now and then visit MasterReplicas.com to obtain some pirate booty of your own!
Items include:
Limited Edition Captain Jack Sparrow Sword
Jack Sparrow Flinklock pistol
Jack Sparrow Compass
12 inch Jack Sparrow figure
Elizabeth Swann necklace
Davy Jones key
and more!
Click here for more information
Lou Mongello
Host, Author & Site Owner
Ooooh! Sounds cool! Thanks for showing us Lou!
I don't know if they showed it in the US before the move, but in the UK there was an ad for a huge Black Pearl ship with moving cannons and all kinds of stuff that is sold extra. It sells for between 50-75bps which equates to almost $100 - $150. I thought the Barbie doll house was expensive and hard to store!
mini-V What will you celebrate?
Adult daycare for the kid inside you.
I just found a site for M&M candy for POC 2. For anyone outside the US who wouldn't see the commercials for the new M&M white pearls, it's worth checking out. They also have a game to play, and two different e-cards that you can email to people. I think the site is : http://www2.mms.com/us/potc2/
mini-V What will you celebrate?
Adult daycare for the kid inside you.
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Jan 17, 2013, 03:51 PM | #1 |
Need Help (Time Machine)
So I'm running a MBP w/ 500Gb HD, OS X Mountain Lion. I have time machine set up to run from an external portable HD.
Yesterday, I needed to recover a file, so I decided to use time machine. Long story short, it "appeared" to copy everything (i.e. entire Macintosh HD) totalling 168GB onto my MBP HD. So now it appears that my HD went from only having 168Gb data on it, to now having over 300Gb data on it. For the life of me, I cannot figure out where all the files that were copied over from time machine went. It said it copied and I checked replace, but it looks like it dumped 168Gb worth of data somewhere. How can I find this data and get my HD back down where it was? |
0 |
Jan 17, 2013, 03:58 PM | #2 |
You can try OmniDisksweeper to help you find where everything went.
If you can't figure it out and if the backup is current, you could command-r boot to recovery and just erase Macintosh HD then restore back from Time Machine |
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By grobmeier
via grobmeier.de
Published: Feb 22 2013 / 09:50
Recently I have got a great new book for my collection: Dart, Up and Running. In this short blog you'll learn if that book is a good one - and how you can read through it for free.
Tags: books, open source, other languages, reviews


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Item: | Dimensions: | Weight: |
Bam Bam Dots Bumper | 89" H x 8" W | 1 lb |
Piece: | Bassinet Pads |
Product Category: | Bassinet Bedding |
Style: | Modern |
Questions & Answers
Each piece of furniture is named from one of the listed wonders of the world. We now have attached hangtags to each piece of furniture, featuring informational text and imagery of the namesake. Each hang-tag teaches the reader (mom and dad) and the listener (child) about the most fascinating and bewildering architecture and scientific phenomenon ever recorded. It is Argington's wish to help bring a love of learning and sense of wonderment into the firm and tangible grounding of a child's home.


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Crosswinds - Apartment Rentals in Wilmington, NC
Crosswinds Apartments Description
Allow Crosswinds Apartments in Wilmington, North Carolina to provide you with the luxurious lifestyle that you have always dreamed of at an affordable price! We are peacefully tucked on residential St. Andrews Drive, near the intersection of S. College Road and 17th Street Extension. All of our 1, 2, and 3 bedroom apartment homes feature fully-equipped kitchens with energy-efficient appliances, as well as patios/balconies and large closets. In addition, many of our apartments underwent renovations to feature redesigned bathrooms and kitchens. Crosswinds distinctive apartment homes provide the best amenity package in Wilmington which includes a 24-hour fitness center, resort-style pool with sundeck and outdoor kitchen, heated indoor pool, free Wi-Fi in the pool areas, lighted tennis courts, sand volleyball court, playground, and leash-free bark park. Call us today to reserve your new home!
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Quick Tips - Not Again!
St. Louis Cardinals all-star slugger Matt Holliday shares what he still deals with in baseball and his most important trait.
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Food oh glorious food ... I've never seen such variety of macarons, cakes, cookies, brownies, and other yummy nibbles at a picnic! What sort of insanity is this? Hahaha, the sort brought about by ChocSuze and Helen. Thanks for the invite!
Held in centennial park, the picnic is a 5 minute bike ride away and so on this sunny Saturday I ran out of the house with camera, hat and my beloved bicycle to get some exercise, eat some amazing food and make new friends!
Got there late, but thank god it was a food bloggers' picnic! Everyone was too busy taking pictures before eating! I thought only I was affected by this terrible affliction.
....mmm... fried goodness...I should've eaten more..think I'm hungry again.
What a pretty sight. Macarons glistening in the sun...the green pistachio macarons were seriously tasty. For real! Who brought these?!
Photos done. Everyone grab that food...no need for forks! (get it? hehe)
Red velvet cookies...and refreshing minty drink? I didn't get the chance to try this ... damn.
Spiced cookie with salted caramel filling. This was good but messy to eat!
Hahaha, love this piggy. But it totally disappeared in a flash!
Gingerbread men. Classic. Good.
Oreo Cookie Turkeys! Ingenious!
We were all gathered around the food. But centennial park is such a nice setting, I need to go there more often.
Amazing little packages of beef salad, with onion and mint. After eating all the sweets, this was my favourite!
Foodisourreligion ... It sure is! Thanks for this =)
Ahh, with tummies all full, the secret santa present giving started. Everyone has a number and the rule is that you can steal from any person with a present before you just once.
Which pressie to choose?
Zumbo's macaron recipe book...my precciouss....Simon obviously wants it! (thanks for the gin and tonic btw)
hahaha - everyone was all smiles before the fighting over this talking cookie jar began.
What is Suze doing? Who knows? But well done to her, and nice shoes too. Can't wait for the next picnic!


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Malware on oil rig computers raises security fears
Svetl. Tebenkova
February 22, 2013 | Updated: February 23, 2013 8:29am
Malicious software unintentionally downloaded by offshore oil workers has incapacitated computer networks on some rigs and platforms, exposing gaps in security that could pose serious risks to people and the environment, cybersecurity professionals told the Houston Chronicle.To continue reading this story, you will need to be a digital subscriber to HoustonChronicle.com.
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Product Recall: One SKU of Velveeta Cheesy Skillet Singles Due to Undeclared Soy: Click Here
MIX beans, salsa and 1/2 cup of the cheese.
SPREAD into 9-inch microwavable pie plate; top with remaining 1/2 cup cheese.
MICROWAVE on HIGH 3 to 4 minutes or until dip is heated through and cheese is melted. Sprinkle with onions. Serve with tortilla chips.


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On Tue, Jul 19, 2011 at 8:21 PM, SKANKTANK said:
thanks for the add...
On Sun, Jul 17, 2011 at 3:51 PM, Frenemy said:
Thanks! I actually submit 7 different designs just the other day. Busted ass on them so I hope at least one of them makes it through! P.s. Conversation 16 one of my favorite songs. Good Taste.
On Fri, Jul 15, 2011 at 12:52 PM, Amanda G said:
i lub kitehs!
On Thu, Sep 9, 2010 at 12:05 PM, Warzone said:
Done and done.
On Mon, Nov 9, 2009 at 7:34 PM, Wicked Celtics said:
if you want Swine Flu all you have to do is ask! Geez. How was your FFF?
On Mon, Sep 28, 2009 at 10:40 AM, Toe Cutter said:
it's a bird, it's a plane
On Thu, Sep 24, 2009 at 1:53 AM, patton said:
Look on my blog and it shall tell you what points are for :)
On Thu, Sep 10, 2009 at 8:32 AM, jellokiti said:
Send not to know what points are good for, they are good for thee.
On Wed, Sep 9, 2009 at 7:38 AM, *iSh diSh* said:
So! since you are so excited about the points, I am hoping you can tell me what they are for!!!!!?????????
On Fri, Sep 4, 2009 at 7:08 PM, tonignosis said:
People with superheroes in their avatars are awesome. Just saying.


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The Charlotte R. Bloomberg Children's Center opened May 1, 2012. Take a look inside at what families and visitors can expect.Virtual Tour
Elevated cholesterol levels return to normal or near normal levels over time in four out of 10 children with uncontrollable epilepsy treated with the high-fat ketogenic diet, according to results of a Johns Hopkins Children's Center study reported in the Journal of Child Neurology. The study appears online ahead of print.
The levels evened out even without changes in fat intake, researchers report.
In their four-year study, the Hopkins Children's team followed 121 epileptic children with intractable seizures on the high-fat, low-carbohydrate ketogenic diet designed to control such seizures.
While most children developed high cholesterol after starting the diet, in half of them, cholesterol gradually improved returning to normal or near-normal levels, with or without modifications to their diet to reduce fat intake.
In fact, researchers point out, diet modifications—including reducing total fat content or certain types of fats called saturated fats and adding nutritional supplements—reduced high cholesterol just as much as doing nothing. High cholesterol is defined as total cholesterol greater than 200 mg per deciliter of blood, bad or LDL (low-density lipoprotein) cholesterol greater than 130, triglycerides greater than 130, and good or HDL (high-density lipoprotein) lower than 35.
Researchers prescribed dietary modifications to increase 'good,' polyunsaturated fats in the diets of 15 children with elevated cholesterol. Dietary modifications decreased cholesterol by 20 percent in 9 out of the 15 (60 percent) children whose diets were modified. Surprisingly, cholesterol also dropped by at least 20 percent in 41 percent of the 37 children whose diets remained unchanged. The findings, while encouraging overall, also mean that relying on diet changes alone may not do much for those children in whom cholesterol remains persistently elevated, and that new approaches for these patients are needed, researchers say.
The findings should come as comforting news to pediatric neurologists, general pediatricians and parents of children treated with the ketogenic diet, and reassure them that, in most patients, increases in cholesterol may be short-lived, researchers say. Previous long-term studies by the Hopkins group of children who were on the diet between six and 12 years echoed these findings. The ketogenic diet, believed to work by triggering biochemical changes that eliminate seizure-provoking short-circuits in the brain's signaling system, is used in many children with hard-to-control epilepsy and in those whose seizures do not respond to traditional anticonvulsant medications.
"We are greatly encouraged by our findings because the nearly half of the children on the diet were either able to maintain healthy cholesterol or gradually metabolized the extra fat and returned to somewhat normal cholesterol levels," says senior investigator Eric Kossoff, M.D., a pediatric neurologist at Hopkins Children's. "This means the benefits of the diet—a diet that is lifesaving in many children and therapeutic in most of them—continue to outweigh the risks."
Noting that 40 percent of children maintained normal cholesterol even after starting the diet, researchers found that children fed a formula-based, liquid-only ketogenic diet were nearly three times less likely to develop high cholesterol. Researches attribute this finding to the nearly zero fat content in commonly used ketogenic diet formulas.
In the group with normal cholesterol, 78 percent of children (31 out of 40) were fed formula-based ketogenic diet. This finding, while requiring further study, points to another possible treatment for high cholesterol, Kossoff says, by switching children with persistently elevated cholesterol to formula-based ketogenic diets at least some of the time. The formula-based ketogenic diet contains only one-third the amount of saturated fats—the worst kind in terms of cholesterol—of the solid food version of the ketogenic diet. Because doctors can tweak the ratio of fat vs. carbohydrates depending on each child's severity of seizures, the investigators examined whether higher-fat versions of the ketogenic diet raised cholesterol additionally, but found that higher-fat ratio had did not make cholesterol worse than a lower-fat ratio.
Some of the other findings:
The research was funded by in part by the National Institutes of Health. Other Hopkins investigators in the study: Juniad Nizamuddin, B.S., Zahava Turner, R.D., James Rubenstien, M.D., Paula Pyzik, B.A.


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CHARLESTON, W.Va. -- March Madness is great.
Of course, it's more fun to follow if you have a team in the hunt. This past season, Mountain State fans had two dogs in Marshall and WVU that were anything but in the hunt.
Yet the hope is you're watching the Madness closely, especially if you follow WVU. Note how fine guard play lifts teams at this stage of the game.
And consider the Mountaineer team. Consider its lack thereof.
I bring this up because of a swirl of news that could turn into a vortex soon.
In a Gazette sports news story last week, WVU coach Bob Huggins inferred that his coaching staff will remain intact. He added that decisions will be made after the spring break on player personnel to avoid knee-jerk resolutions.
Of course Internet rumors never stop swirling. Scout.com said the Mountaineers have offered a scholarship to point guard Devin Wilson of Montour High in McKees Rocks, Pa. My understanding is Huggins and his staff have not offered Wilson, but have shown a lot of interest.
Wilson is a 6-foot-4, 175-pound player who reminds some of a taller ex-Mountaineer Joe Mazzulla.
My understanding is WVU has extended an offer of an official visit to Wilson. Perhaps that works out, perhaps not. The book on the player is he doesn't shoot well, but has speed and can pass.
What WVU needs is a point guard that can shoot. Whether the school can find one or not remains to be seen.
If not, though, the Mountaineers definitely need a point guard with Mazzulla's tenacity and heart.
This past season, WVU missed that almost as much as a shooter's touch and the ability to pass the ball inside. Perhaps more so.
As always, though, there is, well, guarded optimism heading into next season. Incoming four-star recruits Devin Williams and Elijah Macon are in the fold.
And, as outlined here last Wednesday, all four recruits - add Brandon Watkins and Nathan Adrian - will play on the same all-star team in the Scott Brown Classic on April 13 in Beckley.


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More copies of this ISBNThis title in other editionsObama: From Promise to Powerby David Mendell
Synopses & ReviewsPublisher Comments:Barack Obama is arguably the most dynamic political figure to grace the American stage since John F. Kennedy. His meteoric rise from promise to power has stunned even the cynics and inspired a legion of devout followers. For anyone who wants to know more about the man who would be president, David Mendell's Obama is essential reading. Mendell, who has covered Obama for the Chicago Tribune since the beginning of Obama's campaign for the Senate, had far-reaching access to the senator, the details of which he shares in this compelling biography. Positioning Obama as the savior of a fumbling Democratic party, Mendell shows how Obama conquered Illinois politics and paved the way brick by brick for a galvanizing, historic presidential run. With exclusive contributions by family members and advisers, and details on Obama's voting record, this is a complete, complex, and revealing portrait, a must read for anyone interested in American politics in general and Senator Barack Obama in particular.
About the AuthorDavid Mendell, author of Obama: From Promise to Power, has been writing about politics and urban issues for the Chicago Tribune since 1998. Mr. Mendell lives in Oak Park, Illinois.
What Our Readers Are SayingBe the first to add a comment for a chance to win!Product Details
Other books you might likeRelated SubjectsBiography » General Biography » Political History and Social Science » African American Studies » General History and Social Science » Politics » General History and Social Science » Politics » United States » Politics History and Social Science » Sale Books History and Social Science » US History » Presidents » Obama, Barack |


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Thread Tools |
December 14th, 2010, 04:10 PM | #1 |
Senior Member
Trailer question......... Now build thread *update Jul 13*
Check it, I am in need of a car trailer to tow the Jeep around. I can't find anything less than 2500 dollars, and i am kind of a cheap skate. I found a old equipment trailer for 400 dollars in my area. the only problem is the damn thing is only 5ft wide, it is 20ft long however.
My question is would it be feesable and safe to extent it out of the sides to accomidate the jeep? The damn thing has 7000 lb torsion axles on it and it looks sound with only minimum surface rust on it. Thoughts??? Last edited by Frank01TJ; July 13th, 2011 at 10:19 AM. |
December 14th, 2010, 04:21 PM | #2 |
I'm not old, honest...
You're asking wide open questions with not enough information. Pics of the current frame would be very helpful.
Do you have access to the steel and wood you will need to widen it? What is the current track width of the axles. Does it have fenders? If so, are they going to be reusable? If not, are you going to build or buy new ones? Do you have the capability to do the work or do you need to hire it done? Do you have a location capable of handling that size trailer or do you need to rent space? Have you priced out the difference between upgrading and buying new? Finally, there are usable trailers around that go for less than $2500, especially used ones. good luck |
December 14th, 2010, 05:15 PM | #3 |
Senior Member
More info:
Steel and wood are not a problem, I am in camp lejeune and we have a "hobby shop" that can get any materials needed at heavy discounts I have stock track width, so whatever that is, I think outside wheel to outside wheel is about 6ft no fenders i will fab up some drive over fenders i can weld, hobby shop charges 2 dollars an hour to use their Miller's hobby shop can handle trailer size haven't priced out to the T but have a general idea I am having trouble finding decent trailers in NC for under 2500 My main question is: how does one go about widening a trailer, while maintaining integrity so the widened part doesn't break with the first road bump you hit? here are the best pics i can get Last edited by Frank01TJ; July 13th, 2011 at 10:20 AM. |
December 20th, 2010, 12:58 PM | #4 |
Senior Member
Turned this into a build thread, got the trailer for 300 dollars......figured i couldn't pass it up.
This is the i brought it home, gonna start hacking off the Channel pieces that were stuck on the sides, trailers got some surface rust going so after its widened i am gonna POR the piss outta the bottem......Ideas of how to widen? I am thinking of running the same 2X5X1/4 for the outside parts, then run 1 1/2 By square tube every 12" OC for the supports...what do you think? |
December 20th, 2010, 01:10 PM | #5 |
Yeeeee Haaaaw!
I would just built outer runners that just weld on to the outside of the existing frame before and after the tires. I've seel lots of guys do that and it works out fine. You can also add storage in those spots as well if you hinge the wood. You could build it 12-16 inches wide and end up with a trailer plenty wide enough for your needs.
The only thing that I would worry about would be the strength of the existing frame. It looks pretty weathered and rusted. |
December 20th, 2010, 01:12 PM | #6 |
that shouldnt be to hard to do at all
H.o.r.e (mr.green)So you are calling CC a liar?? Not a nice way to treat your bitch. tube bending and gear installs pm me for info! gears installed for $150 and up per axle. |
December 20th, 2010, 01:12 PM | #7 | |
Senior Member
Thanks man |
December 20th, 2010, 02:15 PM | #8 |
I'm not old, honest...
The base trailer you have is no different than most trailers. Almost all trailers have a straight front-to-back runner that supports the springs. So, you are good there. Now you just need to get some similar sized rectangular tubing and weld pieces perpindicular to the main runner. Then cap it with another runner from the front to the tires and from the tires to the rear. Deck over it, add fenders and you are done.
December 20th, 2010, 04:03 PM | #9 |
R&V Ranger
the best pic I have of my trailer...I can go out and snap some more if you need me to....it is all 1.5x1.5 frame work to the outside of the tires and over the fenders stake pockets are still there.The guy that had this trailer had a 4 seat buggy on rockwells and 49's....I have had a 3500 chevy dually loaded backwards and the fenders never flinched
December 23rd, 2010, 04:10 PM | #10 |
Senior Member
Thanks for the input people.. after talking with the Old dudes at the weld shop on base we came up with a plan.
The supports are gonna be diamond plate, in a triangle fashion with a bend at the top for strength. We are gonna take flat bar and cap the diamond as a runner. we went this way for wieght purposes, should be plenty strong enough for years of hauling. got a little work done on it today measuring the diamond Cutting the diamond diamond cut this is what they are going to look like diamond bent Laid out to get our numbers right what they are going to look like front left corner supports done Couple more pics This is where i left off today, can't get back over there untill sunday. We used the diamond because they had a bunch laying around, got it for around 50 dollars.... after its all said and done should have around 600 dollars into the whole thing, including buying the trailer. not too bad for a 14K lb trailer IMO. |
December 26th, 2010, 03:34 PM | #11 |
Senior Member
December 26th, 2010, 03:51 PM | #12 |
Coil springs are for pens
Before you get the fenders finished, now would be an easier time to freshen up the trailers brakes or put some on if it doesn't have any. It's looking good.
December 26th, 2010, 03:52 PM | #13 |
Wasn't this attached?
Brakes are for pussies.
Nice trailer. |
December 26th, 2010, 04:09 PM | #14 | |
Senior Member
I would agree and the 1-ton has enough ass to stop it. But trailer brakes on icy roads will save your hindquarters. |
December 26th, 2010, 05:18 PM | #15 |
Wasn't this attached?
Yeah, I was just being a smartass. With the jeep on the trailer, it needs brakes. They will save your ass in more than just icy roads.
December 27th, 2010, 12:17 AM | #17 |
"The Situation"
I made my trailer from some nice 3" angle iron and a couple of jeep Dana 35's cause people practically throw those damn things out.. I think i have MAYBE $300 into my 22' trailer
now i can pull the s10 my quad my dads quad and my buddy's quad all up north with one vehicle |
December 27th, 2010, 07:41 AM | #18 | |
Senior Member
January 4th, 2011, 04:12 PM | #19 |
Senior Member
Haven't had very many chances to work on the trailer. Got it home though and put the jeep on it. Had to see how much it settled, so i can build the drive over fenders. Started doing lights, lights should be wrapped up tonight.
Heres a couple pics of jeep on trailer All i have left to do is ramps, fenders, lights and tie down points. Should not take too long, just need to find the time. |
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Jersey City, NJ – January 20, 2010 – Lord, Abbett & Co. LLC ("Lord Abbett"), an independent, privately held investment management firm, announced that effective December 31, 2009, it reduced the net expense ratios on both the Lord Abbett International Core Equity Fund (LICAX) and the Lord Abbett International Dividend Income Fund (LIDAX) Class A shares to 1.12%. The net expense ratios had been 1.43% on International Core Equity and 1.35% on International Dividend Income. The new expense ratios are lower than both the Morningstar and Lipper peer group averages of Class A shares in their respective categories, as of December 31, 2009.
The International Core Equity Fund, established in 2003, invests in the stocks of large and mid-sized international companies poised for significant appreciation where valuations may potentially expand and growth may exceed expectations. The Fund currently manages approximately 939 million in assets.
The International Dividend Income Fund, created in 2008, seeks international companies with high yields, sustainable dividends, and below-average valuations to construct a portfolio that potentially rewards investors in two ways: high dividend income and capital appreciation. When Lord Abbett launched the Fund, it was one of the first mutual funds of its kind to offer an international dividend strategy. Current assets in this Fund are $325 million.
Historically, both funds have delivered attractive performance in their respective categories. As of December 31, 2009, the International Core Equity Fund finished in the 35th percentile or better in both its Morningstar and Lipper peer groups for the one-, three-, and five-year periods,* and the International Dividend Income Fund finished its first year in the top quintile of both its Morningstar and Lipper peer groups.**
The lower expense ratios come during a time when Lord Abbett sees greater opportunities for investors in the international markets. "Today, more than half of the world's market cap and almost three times the number of public companies are outside the United States," said Mike Weldon, Lord Abbett Partner & Director of Marketing. "Yet few investors are aware of this breadth and, as a result, typically allocate less than 20% of their portfolios to international markets." Weldon added: "The international markets also offer greater dividend potential to investors, and access to industry sectors, like building products and shipping, that may no longer exist in the United States."
*Lord Abbett International Core Equity Fund: For the one-, three-, and five-year periods ended December 31, 2009, the Fund (Class A) ranked in the 27th percentile (108 out of 399), the 27th percentile (86 out of 320), and the 23rd percentile (62 out of 270) respectively, in the Lipper International Large-Cap Core category; and in the 35th percentile (286 out of 823), the 28th percentile (178 out of 635), and the 28th percentile (131 out of 462) respectively, in the Morningstar Foreign Large Blend category.
**Lord Abbett International Dividend Income Fund: For the one-year period ended December 31, 2009, the Fund (Class A) ranked in the 18th percentile (23 out of 130) in the Lipper International Multi-Cap Value category; and in the 11th percentile (36 out of 340) in the Morningstar Foreign Large Value category.
Sources: Morningstar Inc. and Lipper, Inc.
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Current assets under management depicted for each fund above are as of December 31, 2009.
Please note that Fund expenses may fluctuate with market volatility.
Lipper, Inc. Rankings are based on total performance and do not reflect the effect of sales charges. Each fund is ranked within a universe of funds similar in investment objective.
© 2009 by Reuters. All rights reserved. Any copying, republication, or redistribution of Lipper, Inc. content is expressly prohibited without prior written consent of Lipper, Inc.
Fund rankings within the Morningstar categories depicted above, which may change monthly, are based on total returns calculated by the ranking entity. Rankings do not take into account sales charges, if applicable, but include reinvestment of dividends and capital gains, if any. Morningstar total return percentile rankings for the specified periods are relative to all funds that have the same investment categories. The highest (or most favorable) percentile rank is 1, and the lowest (or least favorable) percentile rank is 100.
© 2009 Morningstar, Inc. All rights reserved. The information contained: (1) is proprietary to Morningstar and/or its content providers; (2) may not be copied or distributed; and (3) is not warranted to be accurate, complete or timely. Neither Morningstar nor its content providers are responsible for any damages or losses arising from any use of this information.
A Note about Risk: Investing in international securities generally poses greater risk than investing in domestic securities, including greater price fluctuations and higher transaction costs. Special risks are inherent to international investing including those related to currency fluctuations, foreign, political, and economic events.
Investors should carefully consider the investment objectives, risks, charges and expenses of the Lord Abbett funds. This and other important information is contained in a fund's summary prospectus and/or prospectus. To obtain a prospectus or summary prospectus on any Lord Abbett mutual fund, contact your investment professional or Lord Abbett Distributor LLC at (888) 522-2388, or visit us at www.lordabbett.com. Read the prospectus carefully before investing.Lord Abbett mutual fund shares are distributed by Lord Abbett Distributor LLC.
Shares of Lord Abbett mutual funds are not deposits or obligations of any bank, are not guaranteed by any bank, and are not insured by the FDIC or any other agency, and involve investment risks, including the possible loss of principal amount invested.
Read our recent announcements and press releases here. For media inquiries or interview requests, please contact our public relations team.


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Hartford Seminary Presents
Ten Week Course
English Writing Course for Theology Students
with Louise AgaseeTuesday, February 5th 9:00 am
Hartford Seminary
60 Lorraine Street
Hartford, Connecticut
United StatesThis course is designed for native speakers and international students to help perfect their writing skills. It includes strategies for academic writing, including essay writing, book reviews and reflection papers. Texts from the three Abrahamic faiths will be used together with definitions of theological concepts and terminology.
Louise Agasee has been teaching the English Language for thirty-six years. At the beginning of her career, she taught English at a private language institute in Egypt for five years. Then she taught at a private business college in Brussels, Belgium, for eight years. She also taught English to political refugees and asylum seekers in Oxford, England. Since 2008, she has been living here in Connecticut and has been doing volunteer teaching at the Bosnian mosque and community center.


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Outreach Committee
Duties and responsibilities: The purpose of the World Service Outreach Committee is to carry the Nar-Anon message of hope throughout the world. This is done by developing and compiling outreach material used to raise public awareness about the Nar-Anon program. The committee will serve as a resource for new and existing local public information services.
Qualifications for membership: In addition to the general requirements for serving on a world service committee, members should have a thorough understanding of Tradition Eleven. Our public relations policy is based on attraction rather than promotion.
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Computer-Based Testing for Occupational Licenses
CBT license examinations offer:
- The convenience of numerous CBT exam sites
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- License issued to applicants passing CBT exam within one week of exam date
- Immediate retesting option before leaving the site after the first of 4 attempts (or 30-day waiting period)
- Only a 30-day waiting period for second and third CBT retests
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Examinations available for CBT by Licensing Program
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- To obtain an application, go to the CBT Application Request Form and submit your request.. An application packet will be mailed to you upon receipt of your request.
Applicants will be notified of approval status in writing within 30–45 days (either an approval or deficiency letter).
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Retesting by CBT after failing a written test is allowed, so long as your application is approved and you have waited at least 30 days after failing the test.
Registered Test Centers
Test Center |
Location |
Phone |
Student Service Center, Room 101 |
806-371-5445 |
512-223-7769 |
El Paso Community College |
915-831-3221 (Jaime Moreno) |
Midwestern State University |
3410 Taft Blvd (Hardin South, Room 224) |
940-397-4676 |
Regional Training Center 624 Six Flags Drive, Suite 130 Arlington, Texas 76011 |
817-608-2310 (Phillis Lowery, Regional Training Center Supervisor) |
Academic Building IV (AB4) on the corner of Bower's Blvd. and Avenues I and J |
936-294-1025 |
Nacogdoches, TX |
936-468-3958 |
Tarrant County College (Northwest Campus) |
WCTS-1113 4801 Marine Creek Pkwy Fort Worth, TX 76179 |
817-515-7653 |
Texas Engineering Extension Service |
TAMU Riverside Campus, Building 7900 |
Houston, TX |
713-313-7387 |
The University of Houston at Victoria |
Ernest Amador, Testing Coordinator Ph: 361-570-4285 |
The University of Texas at Brownsville |
UTB Office of Testing 1601 E. Price Road, Suite E Brownsville, TX 78520 |
956-882-8875 956-882-7084 |
Student Assessment & Testing Office Academic Advising Center Building, Rm 127 Located on Hawthorne St. on the UTEP Campus (campus map at utep.edu) El Paso, TX |
915-747-5009 |
806-651-2341 |
Click on "Current Students" |
817-598-6383 |
Keep checking this Web page for updates and additions to the list of registered CBT sites.


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Updated Monday, August 23rd, 2010
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Posts categorized "NBA"
Michael Jordan still dunking at 50. NBD.
by Jon HenselerIn the interest of full disclosure; I grew up on the Michael Jordan NBA. The Bulls/Pacers, Bulls/Knicks, Bulls/Jazz rivalries with...
Read More » -
Man Card Revocation
by Nick VitranoI'm not against crying. In fact, a sucker for the underdog and a tireless enthusiast for right over wrong…good over evil, I'm a b...
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Bucks deal Jennings to Pistons!
by Jon Henseler(yes this blog just about needs a table of contents) Listen I know the Bucks catch a lot of flack and rightfully so. Pretty much ev...
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What will you do about athletes today?
by Jason MillerSo it's one of those things that when you start thinking about you can't really come up with a great solution. What am I talking a...
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It's time for an Energee boost!
by Nick VitranoWhen your franchise resides in the purgatory of the NBA, there's not much hope for ya as a fan base. I'm lookin' at you, Milwauke...
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The boys are back in town... sort of
by Carolyn BinderThe Detroit Pistons front office seems to be yearning for the glory days; at least the glory days of my generation. The energy and ...
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What happened to the professional athlete?
by Jason MillerI am not saying that I know exactly what it's like to be a professional athlete but as far as my family there are only two cousins o...
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Carlos Gomez Amazing Game
by Jon HenselerWell folks put that one right next to Everybody Loves Raymond in the Carlos Gomez 2013 Boner Jams. Just pure, unadulterated filth ...
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Firefighters responded to a business fire in Chesterfield Sunday night.
The call came in just around 10 p.m. for the Hair By Esther store on Hull Street Road.
Firefighters encountered fire inside the building and in the ceiling.
So far, it appears no one was inside or hurt.
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Peaceful lakes, sweeping vistas, state fair food -- here is our list of 30 essential Midwest experiences. Consider this a checklist for this year's travel, in case it's time to renew the...
Check out a few of our favorite getaways that will suit Midwesterners' new travel priorities.
Indulge in decadent pastries, fresh-baked breads and more at these bakeries we love.
Mount Rushmore is just the first on a long, diverse list of things to see and do in this state, rich with history and natural beauty.
A thunderous bison roundup, trails, scenic drives and small towns all reflect the drama of fall when autumn color arrives in South Dakota's Black Hills.
Show-stopping scenery and a wealth of attractions bring visitors to the Black Hills and Badlands.


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Our Pandan Bath Accessories are a beautiful addition to your bath countertop or vanity. The tissue cover camouflages a boutique-sized box of facial tissue.
We can help! Click here to chat with an expert.
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World's cheapest car, from Tata, set for production
Here's a good way to build a cheap car: take out the airbags, power steering, rear seat belts, antilock brakes, and most cylinders, all frills, and other standard safety equipment. Do that and you'll end up with a four-door, four-seater, 33-hp two-cylinder car that you can sell to a hungry market with decidedly low expectations for about 100,000 rupees ($1,988). This still seems kind of expensive when you consider that you can buy a new Kia Rio for $10,000.
Often called the Model T of the 21st century, the Tata Nano is expected to go into production for the growing Indian automotive market on March 23, with orders being accepted in April.… Read more


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Day 1
We transfer to our hotel in Leon (1h30m). We may have time to visit the city's beautiful gothic cathedral and stroll around its charming winding narrow streets.
Day 2
We head into the countryside riding across the plains of Castilla through cultivated countryside and quaint villages, with adobe houses and wine caves. We will take lunch in Hospital del Orbigo and on entering the village we cross a stunning mediaeval bridge (one of the longest pilgrimage bridges in Spain). We then ride the final 15km to the beautiful walled town of Astorga, with views of the mountains of Leon in the distance. 48 km
Day 3
Today's ride is the most beautiful of the trip as we leave the Castillan plains behind and climb gradually into the mountains of Leon to the Monte de la Cruz de Ferro (1505m). En route we pass through Castrillo de los Polvazares, known for its very special architecture created by strong orange coloured stone. After lunching in the charming mountain village of Acebo (the main street is a straight line of beautiful balconied houses) we enjoy the rest of our descent into Molinaseca, with stunning views of the surrounding valley. 46 km
Day 4
The highlight today is the ride to the beautiful town of Villafranca with stunning views across the green valleys of Galicia and wooded mountains of Leon. After the first easy and mainly flat 25km we have a short climb to Villafranca, which is worth a look for its many monuments and picturesque town square. Once we reach the bottom of the valley on the foothills of Monte de O'Cebreiro we will have a rest before our final push to the top of the mountain and the small village of O'Cebreiro. Here we will be able to appreciate wonderful views of the valleys that surround this peak and admire the charming slate roofed black houses. 60km
Day 5
As we enter Galicia the landscape changes dramatically and the area is populated by a number of traditional agricultural villages. Each family has small plots of land, which they cultivate for their own vegetables and we will pass by many of the locals working the land and tending to their cattle. As well as a change in culture, landscape and language, the gastronomy of Galicia is famous for using products of high quality and preparing them in simple and not elaborate, but delicious ways. Before ending the day at Sarria there is time to visit one of the oldest monasteries in Spain at Samos. 50km
PREMIUM DEPARTURES: we end the day in Portomarin. Distance: 69km
Day 6
Today's ride runs through beautiful rural Galician countryside and along tree-lined paths to the town of Portomarin, which was rebuilt on a hilltop in the 1950s in order to construct a reservoir. After trying the local speciality of octopus we head to Palas de Rei, a small town full of the pilgrim spirit. 54km
PREMIUM DEPARTURES: we end the day near ArzÚa. Distance: 48km
Day 7
Our final day involves a number of short ascents and descents as far as Monte de Gozo, where we take in our first views of the towers of the Cathedral of Santiago de Compostela. As the pilgrims have done for centuries, we wind our way through the city's streets and crowds to Plaza del Obradoiro, dominated by the impressive Cathedral of Santiago de Compostela.
We then move onto the Pilgrim's Office for those who wish to obtain the 'compostela' (certificate of accomplishment). 67km
Day 8
Transfer to Oviedo (approx. 3h). Fly to London.


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Revised July 2010. Offers basic facts about club drugs (GHB, ketamine, and rohypnol), including how they affect the brain and other parts of the body, treatment options, and how widespread the use is of these drugs. En Español
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DrugFacts, formerly called InfoFacts, present scientific facts about drug abuse and addiction.
Call 1-877-643-2644 or:


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out of the box arrows or already used arrows
This is a discussion on out of the box arrows or already used arrows within the Hunting Africa forums, part of the Hunting Forums - Hunting in Africa category; hello every one, i'm leaving in one month in Southafrica and i'll be bowhunting over there. Since it's the first ...
05-16-2013, 11:32 AM #1AH Veteran
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out of the box arrows or already used arrows
hello every one, i'm leaving in one month in Southafrica and i'll be bowhunting over there. Since it's the first time i'll be bowhunting i've got a few questions:
i'm wondering if (for hunting) i should used out of the box never used arrows of if i can use arrows i already shot on targets ?
- Member of SCI,DSC, QDMA, QU
- Hunted Africa...are there other continents to hunt?
Use the arrows you have shot at targets as long as the fletching is clean and straight and there are no nicks in the carbon. I always shoot "shot" arrows.
- Hunted USA , Canada, Botswana
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Tom answer is very valid. Shot arrows, as long as they are in good condition, have the advantage of one knowing that they fly where you aim.
New "out of the box" arrows need to be spin tested with the broad-head attached. to make sure both the nock and the point both spin true without any wobble,When I am not hunting, I am thinking about hunting....I think I'll go hunting.
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You don't need to go out and buy new arrows just for your trip if you already have plenty of arrows that are in good shape and already tuned to your current set-up. Using arrows that you already know will fly true are fine as long as the fletchings are in good shape and there is no apparent damage to the shafts....If you buy new arrows and broadheads for the trip, I strongly suggest that you shoot them several times each before you take them to the field to hunt to ensure that they are flying in tune...
Inexperinced bow hunters often assume arrows right out of the box will fly exactly the same way as their other arrows...Don't learn that lesson the hard way... I've personally bought arrow shafts from the same manufacturer with the same spine and same advertised grains per inch that had completely different flight characteristics than the same exact shafts I had purchased a year prior. Some set-ups will show very little deviation even with sizably different total arrow weights, different fletchings, etc. My bow is very fast and not very forgiving. The smallest deviation with my set up makes a big difference in the point of impact for me. Don't assume your set up will be the same just because your arrows are the same... For Africa, I usually mark a half dozen arrows that I shoot the tightest group with and only use those on trophy animals. I take another dozen or so to shoot varmints, cull animals, etc...
Whatever arrow/broadhead combination you intend to hunt with is exactly what you should be practicing with now. Also, shoot your bow once you arrive in camp. My bow has been knocked out of tune 4 out of 4 trips to Africa... I don't know how they do it...?
Practice, study your shot placement, and you will have lots of success. Good Luck & have fun!
- Member of KZN Hunters Assoc
- Hunted Namibia (Otavi, Ozondjache) South Africa ( LP, KZN, NC, EC) Botswana (Ghanzi) Canada (BC, AB, SK, MB, Ont, PQ, NS) USA (MT, WA, SD, CA, CO, WY, KS, MN, NC, VG, UT, HI)
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Perhaps like this.
Attachment 19497Practice whispering before you leave for Africa!
A Legend in my own mind!
05-21-2013, 11:05 AM #6AH Veteran
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thanks everyone
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The book publishers for Pictures from Paradise
Tags: pictures from Paradise Great books from the Caribbean
Sexypink is THE definitive site for Art from Trinidad & Tobago, the Caribbean & the Americas. The objective is both to enjoy imagery, feature quotes and continue in the vein of Sexypink of the past. ~Welcome


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Shivering Timbers with Darlene
10 p.m., Saturday February 16 | Free.
Where: MOTR Pub
Phone: 513-381-6687
Address: 1345 Main St.
Website: www.motrpub.com
A moving story about a 21-year-old guy and his 91-year-old grandmother helping each other in a time of need. Despite their 70 year age gap, a comradeship grows between the two as they spend t ...
The Augusta Art Guild is seeking artists who create original work to be apart of the annual Art in the Garden event, which will take place Saturday, June 7 at 10 a.m.-5 p.m. Artists have unti ...