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Ooooooooooh! Regular Shoooooooooow!
Tony Ponce
on 03.11.2012
Yesterday, I
this picture. What is this a picture of? The new
Regular Show
DVD, of course!
But wait a minute, you reply. There is no
Regular Show
DVD in stores! How did you get hold of this? Simple: Cartoon Network GAVE it to me. This DVD doesn't go on sale until April, but a copy was shot my way because I wrote
this article
last year.
Let's crack this bitch open.
You won't believe how lazy the box art for this thing is. It looks like the text was written in Paint. I would expect no less from this show.
Boom! "Over the Top" is in this collection! Instant gold!
Just like with LSP and the
Adventure Time
DVD, Pops adorns the disc art here.
Now, I didn't get this DVD just because I'm a big fan... no, no. Naturally, there was something more to the offer.
I'm not saying anything, but if I were to happen to, I dunno, talk to series creator JG Quintel in the near future, what kind of questions would you want me to ask him in regards to how he incorporates his love for videogames into the show? This is just a supposition. I'm not "saying" anything, wink wink.
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(4 photos)
I'm-a Luigi, bitches! Numbah 1!
Tony Ponce
on 10.31.2011
This is how I fuck up the ceiling in the office.
view gallery
(2 photos)
Who wants to go to Nerdapalooza in Orlando with me?
Tony Ponce
on 07.01.2011
Hey there, all you
Chilly Willies
! It's been a while since I've popped up on the community blogs. It's been way too long, I know!
Anyway, I've got a message for all my Florida peeps. From July 15 through 17 (two weeks from now),
will be going down in Orlando. If you've never heard of it, it's an annual geek music festival featuring the hottest in nerdcore and arranged game tunes and what not. They've got great acts like brentalfloss, Mega Ran, Metroid Metal, The OneUps, The Protomen, and others, including a personal fave of mine, 8-bit Duane. It sounds like a blast and a half, doesn't it?
I am most definitely going, although I wouldn't mind having a bit of company. I really would like to go all three days, but I may end up just going on Saturday (that's when all the best performers play, anyway). If you are in Orlando or a few hours away, please stop on by! Just let me know by shooting an email to
megastryke AT gmail DOT com
tony AT destructoid DOT com
, or send me a message on
Any takers? I'll be your best friend!
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(1 photo)
C Blog style and formatting tips
Tony Ponce
on 03.31.2011
My good buddy Andrew Kauz recently became the site's new C Blog Boss, a role that tasks him with keeping an eye out for exceptional posts and offering useful tips and guidance to those in need. Of course, no one would expect just one man (
One man!
) to shoulder all that responsibility on his own. The rest of the staff is more than happy to offer a few words here and there.
In case you weren't privy to my credentials, I too am a C Blog graduate -- both Andrew and I were promoted to front-page editors at roughly the same time last year. After hearing concerns that the quality of user blogs was diminishing, I decided to compile a super post concerning proper blog style and formatting. Over the course of a few weeks, I continuously added to that post, resulting in the beast now before you.
Some of this information may be criminally obvious to some, but I wanted to be as comprehensive as possible. I've touched upon just about every formatting subject I could think of, from the proper use of BBCode tags to little multimedia tricks. If you find even just one useful nugget amongst my rambling, I will have done my job.
If you have any further questions or amendments, let me know in the comments below. You can also contact me via email at
megastryke AT gmail DOT com
tony AT destructoid DOT com
Every so often, someone complains because their newly published post is nowhere to be found. Upon closer inspection, it's either halfway down the list or on a subsequent page. Why does this happen? Our blogging software is a bit backwards -- instead of setting a timestamp when you publish a blog, it sets a timestamp the
you start a new one. If you start writing at 12 PM and finish at 6, you better hope it's been a slow day.
The smart thing to do is to compose your piece in a separate editor. For the longest time, I would type up everything in a Notepad file, but you can also use Google Docs, Word, or any word processor of choice. Once you've proofread your work a couple of times, copy and paste it into the Dtoid editor.
Though convenient, this method doesn't allow you to check how your post would appear live in various states of completion. You'll want to know every so often whether your BBCode is broken or an image doesn't appear correctly, not at the very end when all your errors appear at once. For short-form blogs, the extra work may be manageable, but for long-form pieces...
I propose another method! Start up a new blog and type something like "FOR DRAFTS ONLY!!!" as the title. You are going to keep this blog in private view mode as your test center for all future blogs. Type out everything as you normally would, then add images, video, the works. Once you are 100% confident that your piece is ready for the public, start
new blog and copy everything over. You may need to re-upload photos and re-embed videos, but your post-editing work will still be greatly reduced. When it's time to bake a fresh post, return to the test blog, clear it, and start from scratch.
It's prudent to discuss spelling and grammar very briefly before moving on. This isn't English class -- no one is going to get all up in your grill for having a few too many typos as long as the overall blog is legible. At the same time, lax standards is no excuse for avoiding the most basic of writing rules.
1. Consult a dictionary
If you want to use a word and are unaware of either its context or proper spelling, don't guess. Reach for a dictionary and look it up. It doesn't take more than a few seconds, and there are so many available resources. If you don't have Merriam-Webster bookmarked, you can use Google's built-in dictionary. Right in the search bar, type "define:" followed by the word. As long as your spelling is close enough, you should hit the appropriate entry. For Firefox and Chrome users, there are various add-ons to help you look up definitions in-line while browsing through articles for research.
2. Use proper capitalization
I don't care how lazy you claim to be, hitting the SHIFT key with your pinky is not some Herculean Labor. The first word of every new sentence should be capitalized, proper nouns should be capitalized, the word "I" should be capitalized... you get the picture. It's not a writer's quirk to pick and choose when to follow capitalization conventions. It's just plain ugly.
3. Mind your punctuation marks
You ought to know how periods and commas work, so exercise that knowledge. However, it's not a bad idea to pepper a some of the more uncommon punctuation marks now and then. It gives your work a little pizzazz! Use ellipses (...) to show trailing thoughts, semicolons (;) in place of a conjunction to join sentences, and so on. Just don't go overboard! Use 'em sparingly, and research their functions if you have doubts. Don't feel like you need to use extra punctuation. Sometimes less is more.
You could be the greatest wordsmith of the modern age, but if you clump all your text together into one giant wall, you'll scare all your potential readers away. Don't be afraid to punch that ENTER key.
In school, we're taught that paragraphs ought to be at least four sentences long, consisting of a topic, a body, and a conclusion. That's well and dandy for academic papers, but it's bullshit in the real world. In the world of journalism (and for the sake of this lesson, I'm treating game bloggers as journalists), you have a bit more freedom with the construction of your paragraphs. Sure, it's still true that a paragraph ideally should follow a singular thought, but it's not rare to see two- or even single-sentence paragraphs.
As an example of someone who really knows how to insert breaks, here's fellow editor
Chad Concelmo
. You may think that his paragraph blocks are a tad on the slender side, but I think that it helps to give his articles a nice flow. You never feel overwhelmed since all the text is divided into easily digestible chunks.
Of course, it's not as simple as devoting a single line to every sentence. If the tone of your article is more serious, you may want to group a few more sentences than normal to properly flesh out an idea. Don't go crazy with a fifteen-sentence nightmare that takes up half the screen, though.
This is the blogger's toolbox. Proper use of BBCode will give your writing
. It's useful for making simple subject headers, stressing certain words and phrases, and more. Unfortunately, even bloggers who have been around for a while can lose their grip on the finer workings. BBCode can be a finicky mistress sometimes, seemingly choosing not to work as intended.
When you are using the built-in editor to write a new post, you'll notice a little cheat guide in the bottom-right hand corner entitled "BBcode help." It is not a comprehensive list of BBCode tags in existence, but it'll serve you satisfactorily here.
The bold and italic tags are self explanatory -- just insert a word or phrase between the open and close tags and you'll get
nyaa nyaa
Speaking of italic type, you ought to use it whenever discussing a movie, book, game, or any other media title. It's what the pros do. For example, when talking about Total War: Shogun 2, render it as
Total War: Shogun 2
. Aside from being proper, it'll grab the attention of readers who are scanning an article or blog for mention of a particular game that catches their fancy.
The URL tag can be used to linkify either a URL address or string of text. By just dropping an address between the open and close tags, you'll get:
Usually, you'll want to direct your readers to some interesting off-site gem via a text flag as opposed to a lengthy address. In that case, insert an equal sign after the "url" in the open flag, then drop the address right next to that (no quotation marks necessary). The address becomes part of the open tag, and whatever you insert between the open and close tags will then lead you to that address, like so:
This recipe was a gift from the Gods.
There are other BBCode tags in existence, but for the most part they don't work with our blogging software. Some do, however. I personally have used the size and color tags in the past:
<numerical value here>
<hexidecimal color value here>
The size tag changes your font size so that you can have
text. The default value is 12, so adjust accordingly. Be reasonable and don't use extreme values, although it's sometimes fun to hammer out a hidden message in size 1 font and force readers to copy and paste it into the search bar in order to view it.
Hello. My name is Inigo Montoya. You killed my father. Prepare to die.
The color tag changes font color, natch. A few colors like red or blue can be written out in English following the equal sign and without the number symbol, but for most you'll need the proper hexadecimal value. For instance, the value E18B6D gives you a nice
hue, while 00FFFF gives you
Mega Man cyan
. A quick Google search will yield a variety of useful color value tables, but make sure the color you pick stands out well on Dtoid's standard white backdrop.
You can even nest tags, one inside another. The following line makes uses of the URL, color, size, italic,
bold tags:
Lament, my lost childhood.
There might be a limit to how many tags you can cram together, but I doubt anyone is gonna to hit it. Five tags is already pushing the boundaries of sensibility, but if you want to prepare a BBCode turducken, the option is available to you.
With all these tags flying around, it's very easy to omit a close tag or to use the wrong tag pair from time to time. That's why you should frequently slam the "Save to drafts and preview" button below the editing window and preview your blog by clicking the link near the top of the page. Make sure everything is sorted out before publishing your piece. Having broken BBCode all over the place is disgusting and a sign that you were in a rush. Broken BBCode can also indicate that someone has copied and pasted an article written on another blog -- since different sites use different blogging software, it's rarely going to be one size fits all.
Sometimes, it may look like your code should function perfectly but doesn't. Say you want to bold the section heading and this happens:
[b]Making Mayonnaise
Work for You[/b]
BBCode hates newline characters, the most common being the space you create when you hit the ENTER key. Essentially, the code will only work if the open and close tags are in the same block of text. Going back and merging my two lines together will give me:
Making Mayonnaise Work for You
Much better!
Other times, the code won't work even if everybody is hanging out on the same line. There is a trouble-maker somewhere. Maybe the newline character is masquerading as whitespace character (which can sometimes happen when copying and pasting quotes from other articles) or there is excess whitespace in either the open or close tags. Save yourself a massive headache by deleting the entire line and re-typing it manually. That usually solves everything.
You may have noticed that I held off discussing one other BBCode tag. That's because I'm giving it its own special section below.
A smattering of pictures can make your dull blog spectacular! Some people like tossing up non sequitur images, but typically you'll want to have pics that directly relate to your topic. Also, make a habit of including a header image in each blog. It's more welcoming than a straight-up block of text.
I still see a lot of you guys using third-party hosting sites like Photobucket and Imageshack, and if you're comfortable doing that, go ahead. I'd like to direct you toward an alternative. On the right side of your editing window, you'll notice a box labeled "Upload photos." You can add your photos and have them stored right here on Dtoid's servers.
There are a few benefits to using local image hosting. Most importantly, off-site images are at the mercy of the respective terms of service. What's appropriate for Destructoid may not be appropriate over there. Also, server failings may cause photos to spontaneously vanish into the ether, leaving a lovely "image not found" macro in your blog. By using Dtoid as your host, you are guaranteed the safety of your images for as long as this site remains active. We monitor our servers like a hawk and promise to recover any lost images in the event of a catastrophe almost without fail.
The standard column width of a Dtoid blog is 620px. If you use third-party hosting, make sure your images are scaled accordingly. It's not a problem if your picture is skinnier than the column, but if it's fatter, everything beyond the boundaries will be cropped off. If you upload your pics to Dtoid, they will automatically be scaled up or down to fit neatly in the column.
The following two images were uploaded to TinyPic:
The first image fits in the column with plenty of room to spare. The whole image is visible, but all the excess space is rather unappealing. With the second image, a reader who wanted to view the whole thing would have to right-click it and select "View Image Info." That's a hassle.
Now, here are those same images hosted locally:
Isn't that a lot cleaner?
When you upload images here, all the photos you attach will appear at the bottom of your post as thumbnails. Clicking any one of them will open a slide show gallery in which you can view the photos in their native resolution. If you want to post a PAX photo gallery, upload all the photos but don't actually insert any image into the body of the blog. That way, you can lead with a short introduction and have your readers pick and choose which photos to view in the gallery.
Uploading an image to a particular blog doesn't exclude you from reposting that same image multiple times in future blogs. With that in mind, you can create a new private blog to host all of your pics, then insert them into various blogs as needed. This also prevents a thumbnail gallery from generating, if you consider them too distracting.
The above photo was uploaded to one of my previous blogs. As you may notice, it doesn't appear in the gallery at the end of this post.
Sometimes, you'll want to post a small image without it being automatically resized. The O-face pic above has this address:
If I replaced the dimension value with the phrase "noscale," I get:
Now, if I insert this new address into the image tag, I get:
With this particular image, we have the same issue as previously -- too much excess space. However, really tiny images roughly the size of a user's avatar could fit right on a line adjacent to a block of text. Possibilities, people.
One other little "hack" deals with centering an image that doesn't fill up the column width. To the best of my knowledge, there's no way to do that with the site's implementation of BBCode. However, we can cheat a bit by adding a buffer to each side of an image, resulting in an 620px-wide image. Taking the O-face pic once again, I just open up Photoshop, add a bit of whitespace, and ta-da:
The buffer on each side of the main image is colored white, so it blends in with the page background, thus granting the illusion of a centered image.
Giving your audience a short break from reading to enjoy an entertaining YouTube clip is always a nice treat. Instead of directing them off-site via a link, embed the clip right in the body of your blog. Embedding video is only slightly more complicated than uploading images, but it causes more problems for users than any other function I've already discussed.
Go to YouTube and find a clip that you'd like to share. Below the video player, there should be a button labeled "Embed." Click that and copy the HTML code that appears (sometimes, you'll get a notice that embedding had been disabled, so beware). Below the image uploader on your editing window, you'll notice a box labeled "Embed videos." Paste your code right in there and upload. The HTML will be converted into BBCode which can be easily added to your post as such:
Wait! You're not finished! This embed suffers the same problem as an off-site hosted image. Many web videos are 640px wide and must be resized to avoid cropping. Here's the original embed code for the
Panty & Stocking
clip above:
<iframe title="YouTube video player" width="
" height="
" src="http://www.youtube.com/embed/nEpy0znKHWs" frameborder="0" allowfullscreen></iframe>
We need to change the width and height values. I like all my videos to be 620 x 378 because it'll display widescreen video accurately and 4:3 video with black bars on the side as on a TV. So I alter the numbers:
<iframe title="YouTube video player" width="
" height="
" src="http://www.youtube.com/embed/nEpy0znKHWs" frameborder="0" allowfullscreen></iframe>
When I upload the new code, I get this:
Compare this to the previous embed. It's a subtle but clear difference.
Can you embed video from sites other than YouTube? As long as the video in question has HTML embed code, of course you can! Here's a video from GameTrailers:
Video Games
Angry Video Game Nerd: Bugs Bunny's Birthday Blowout
Xbox 360
PlayStation 3
Nintendo Wii
PC Games
The embed code from some sites can be quite long. Your quest is to find
height and width value and change them accordingly. Missing a single value may or may not screw up your embed, but as mama always said, it's better to be safe than sorry.
Can you embed media
than video, like a music player? Hell yes, you can! The
Zero Cool
cats do it all the time! As long as the associated media has embed code, you are in the clear:
Podcast Powered By Podbean
If you are still with me, congratulations! Again, let me know if you have further questions or if you find error with any of my instructions. Now get writing!
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(11 photos)
As days go by, it's the bigger love of the family
Tony Ponce
on 09.28.2010
This blog is about love, and not just any kind of love! The sitcom family kind! I've got mad, mad love for
, two cool cats who missed my presence at PAX so dearly that they sent me some mementos for me to treasure for the rest of my days... or at least until trash pick-up.
Qalamari adopted my avatar (along with
's) for grand photo opportunities up in Seattle. Sadly, his mishandling brought about our untimely deaths. As detailed in
this post
, Qalamari had us cloned and shipped off to our respective homes.
And so...
My original body has been returned along with my new and improved clone body care of
I thank both you and Grumpy for putting all this together, Qali. One love.
What ho? Seems like Funktastic sent me something as well. Boy, it's a big one!
Sweet! A copy of
Dokapon Kingdom
, the board game/RPG hybrid from Funk's favorite company evarz, Atlus! Shame I lack a second DualShock for multiplayer fun. I'll need to correct that error immediately.
I also scored an oxymoronic micro Mega Man pin! More Mega Mans for my collection! Get it? "Micro Mega"? Right on, brother!
Oh, you guy, you! Isn't that just like... wait... a Bobble Budd? I didn't notice any Bobble Budd! Where did I leave that box...?
Oh, it's a sour-faced Servbot! Hey, little guy! Did you make that long journey from Canada all by your lonesome? Awwww! Fear not! I've got someone I'd like you to meet!
Almost like looking into a mirror, eh? But wait! Who are those guys in the distance?
Le gasp
! Giant Servbots! A real family at last!
Group photo! Happy days are here again!
Thanks for making this magic happen, fellas! I'll return the favor tenfold some day! Mark my words!
view gallery
(13 photos)
Pixel Art: Bit Transmutation
Tony Ponce
on 06.28.2010
If you've listened to the latest Bit Transmission, you should be aware of a
going down on the forums. Conrad has released the official BT sprite pack and is giving everyone until midnight this Friday to make an original piece using those sprites. I myself can't enter, but I still wanted to get the creative juices flowing.
I've posted all this on the forums already and am re-posting here because (1) I'm an attention whore, (2) I worked hard on this, and (3) OMG look how cute I made everybody!
I've been on this huge
Fullmetal Alchemist
kick lately and thought it would serve as the perfect theme. How to work that into a piece, though? I noticed that there are sprites for seven Bit Transmission hosts and guests. Coincidentally, there are seven Homunculi in the world of
I give you
. starring (in order of appearance)...
Colette Bennett
The sexy and alluring Colette makes the perfect Lust! Feisty and deadly! To complete the look, I grew out her hair a bit. Now she's even hotter.
Chad Concelmo
Chad is definitely not the sadistic, jealous type. However, he and Envy share a common flair for flamboyancy. After Chad's transformation, I was shocked by how much he looks like Sailor Moon. I was worried that I made him too feminine-looking, but it kinda fits Envy's androgyny.
Topher Cantler
Topher has always come across to me as the quiet, soft-spoken guy who enjoys taking it easy. I knew he had to be Sloth, but there was one tiny problem -- Sloth is a hulking behemoth while Topher is a stick. Taking some creative liberties, I constructed a new body entirely from scratch, retaining only the head. Now he looks more like Brad Nicholson, but I doubt he'd complain about the extra bulk.
Jonathan Holmes
Speaking of bulk, I'm sorry, Jon! You have the roundest gut among the cast! Don't hurt me! I also hope you don't mind that I shaved off what little hair you had left. Playing a role is a commitment!
Ashley Davis
The cute and adorable Ashley Davis is my pick for the cute and adorable Selim Bradley. Watch out, though! Like Selim, Ashley conceals a
reservoir of unfathomable evil
Conrad Zimmerman
Conrad is the Bit Transmission ringleader and the only cast member with a full mustache. Who better than him to lead as the Führer? His outfit was the most fun to design. And he dual wields!
Dale North
By process of elimination, Dale is Greed. Honestly, I don't think the role fits... or maybe it does. Maybe Dale is a huge pimp who wants all the money and ladies in the world. Maybe he's biding his time for a full website takeover. Who knows?
...and featuring
Mr. Destructoid
I had to include Mr. Destructoid in the festivities! He is the big man in command. He is Father, and he will fuck you up.
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(2 photos)


text:
Hereditary deafness affects approximately 1 in 2,000 children. Mutations in the gene encoding the cochlear gap junction protein connexin 26 (CX26) cause prelingual, nonsyndromic deafness and are responsible for as many as 50% of hereditary deafness cases in certain populations. Connexin-associated deafness is thought to be the result of defective development of auditory sensory epithelium due to connexion dysfunction. Surprisingly, CX26 deficiency is not compensated for by the closely related connexin CX30, which is abundantly expressed in the same cochlear cells. Here, using two mouse models of CX26-associated deafness, we demonstrate that disruption of the CX26-dependent gap junction plaque (GJP) is the earliest observable change during embryonic development of mice with connexin-associated deafness. Loss of CX26 resulted in a drastic reduction in the GJP area and protein level and was associated with excessive endocytosis with increased expression of caveolin 1 and caveolin 2. Furthermore, expression of deafness-associated
Kazusaku Kamiya, Sabrina W. Yum, Nagomi Kurebayashi, Miho Muraki, Kana Ogawa, Keiko Karasawa, Asuka Miwa, Xueshui Guo, Satoru Gotoh, Yoshinobu Sugitani, Hitomi Yamanaka, Shioko Ito-Kawashima, Takashi Iizuka, Takashi Sakurai, Tetsuo Noda, Osamu Minowa, Katsuhisa Ikeda
Aberrant expression of the secreted protein, acidic, cysteine-rich (osteonectin) (
Houda Alachkar, Ramasamy Santhanam, Kati Maharry, Klaus H. Metzeler, Xiaomeng Huang, Jessica Kohlschmidt, Jason H. Mendler, Juliana M. Benito, Christopher Hickey, Paolo Neviani, Adrienne M. Dorrance, Mirela Anghelina, Jihane Khalife, Somayeh S. Tarighat, Stefano Volinia, Susan P. Whitman, Peter Paschka, Pia Hoellerbauer, Yue-Zhong Wu, Lina Han, Brad N. Bolon, William Blum, Krzysztof Mrózek, Andrew J. Carroll, Danilo Perrotti, Michael Andreeff, Michael A. Caligiuri, Marina Konopleva, Ramiro Garzon, Clara D. Bloomfield, Guido Marcucci
Focal segmental glomerular sclerosis (FSGS) is a primary kidney disease that is commonly associated with proteinuria and progressive loss of glomerular function, leading to development of chronic kidney disease (CKD). FSGS is characterized by podocyte injury and depletion and collapse of glomerular capillary segments. Progression of FSGS is associated with TGF-β activation in podocytes; however, it is not clear how TGF-β signaling promotes disease. Here, we determined that podocyte-specific activation of TGF-β signaling in transgenic mice and BALB/c mice with Adriamycin-induced glomerulosclerosis is associated with endothelin-1 (EDN1) release by podocytes, which mediates mitochondrial oxidative stress and dysfunction in adjacent endothelial cells via paracrine EDN1 receptor type A (EDNRA) activation. Endothelial dysfunction promoted podocyte apoptosis, and inhibition of EDNRA or scavenging of mitochondrial-targeted ROS prevented podocyte loss, albuminuria, glomerulosclerosis, and renal failure. We confirmed reciprocal crosstalk between podocytes and endothelial cells in a coculture system. Biopsies from patients with FSGS exhibited increased mitochondrial DNA damage, consistent with EDNRA-mediated glomerular endothelial mitochondrial oxidative stress. Our studies indicate that segmental glomerulosclerosis develops as a result of podocyte-endothelial crosstalk mediated by EDN1/EDNRA-dependent mitochondrial dysfunction and suggest that targeting the reciprocal interaction between podocytes and endothelia may provide opportunities for therapeutic intervention in FSGS.
Ilse Daehn, Gabriella Casalena, Taoran Zhang, Shaolin Shi, Franz Fenninger, Nicholas Barasch, Liping Yu, Vivette D'Agati, Detlef Schlondorff, Wilhelm Kriz, Borje Haraldsson, Erwin P. Bottinger
The autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA) results from low levels of survival motor neuron (SMN) protein; however, it is unclear how reduced SMN promotes SMA development. Here, we determined that ubiquitin-dependent pathways regulate neuromuscular pathology in SMA. Using mouse models of SMA, we observed widespread perturbations in ubiquitin homeostasis, including reduced levels of ubiquitin-like modifier activating enzyme 1 (UBA1). SMN physically interacted with UBA1 in neurons, and disruption of
Thomas M. Wishart, Chantal A. Mutsaers, Markus Riessland, Michell M. Reimer, Gillian Hunter, Marie L. Hannam, Samantha L. Eaton, Heidi R. Fuller, Sarah L. Roche, Eilidh Somers, Robert Morse, Philip J. Young, Douglas J. Lamont, Matthias Hammerschmidt, Anagha Joshi, Peter Hohenstein, Glenn E. Morris, Simon H. Parson, Paul A. Skehel, Thomas Becker, Iain M. Robinson, Catherina G. Becker, Brunhilde Wirth, Thomas H. Gillingwater
Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive fibrotic scarring in the lung that ultimately leads to asphyxiation; however, the cascade of events that promote IPF are not well defined. Here, we examined how the interplay between the ECM and fibroblasts affects both the transcriptome and translatome by culturing primary fibroblasts generated from IPF patient lung tissue or nonfibrotic lung tissue on decellularized lung ECM from either IPF or control patients. Surprisingly, the origin of the ECM had a greater impact on gene expression than did cell origin, and differences in translational control were more prominent than alterations in transcriptional regulation. Strikingly, genes that were translationally activated by IPF-derived ECM were enriched for those encoding ECM proteins detected in IPF tissue. We determined that genes encoding IPF-associated ECM proteins are targets for miR-29, which was downregulated in fibroblasts grown on IPF-derived ECM, and baseline expression of ECM targets could be restored by overexpression of miR-29. Our data support a model in which fibroblasts are activated to pathologically remodel the ECM in IPF via a positive feedback loop between fibroblasts and aberrant ECM. Interrupting this loop may be a strategy for IPF treatment.
Matthew W. Parker, Daniel Rossi, Mark Peterson, Karen Smith, Kristina Sikström, Eric S White, John E. Connett, Craig A. Henke, Ola Larsson, Peter B. Bitterman
The transcription factor SOX2 is an essential regulator of pluripotent stem cells and promotes development and maintenance of squamous epithelia. We previously reported that
Hideo Watanabe, Qiuping Ma, Shouyong Peng, Guillaume Adelmant, Danielle Swain, Wenyu Song, Cameron Fox, Joshua M. Francis, Chandra Sekhar Pedamallu, David S. DeLuca, Angela N. Brooks, Su Wang, Jianwen Que, Anil K. Rustgi, Kwok-kin Wong, Keith L. Ligon, X. Shirley Liu, Jarrod A. Marto, Matthew Meyerson, Adam J. Bass
Bone metastasis is a frequent complication of breast cancer that is often accelerated by TGF-β signaling; however, little is known about how the TGF-β pathway is regulated during bone metastasis. Here we report that deleted in liver cancer 1 (DLC1) is an important regulator of TGF-β responses and osteolytic metastasis of breast cancer cells. In murine models, breast cancer cells lacking DLC1 expression exhibited enhanced capabilities of bone metastasis. Knockdown of DLC1 in cancer cells promoted bone metastasis, leading to manifested osteolysis and accelerated death in mice, while DLC1 overexpression suppressed bone metastasis. Activation of Rho-ROCK signaling in the absence of DLC1 mediated SMAD3 linker region phosphorylation and TGF-β–induced expression of parathyroid hormone–like hormone (PTHLH), leading to osteoclast maturation for osteolytic colonization. Furthermore, pharmacological inhibition of Rho-ROCK effectively reduced PTHLH production and breast cancer bone metastasis in vitro and in vivo. Evaluation of clinical breast tumor samples revealed that reduced
Yufeng Wang, Rong Lei, Xueqian Zhuang, Ning Zhang, Hong Pan, Gang Li, Jing Hu, Xiaoqi Pan, Qian Tao, Da Fu, Jianru Xiao, Y. Eugene Chin, Yibin Kang, Qifeng Yang, Guohong Hu
Cleft lip, which results from impaired facial process growth and fusion, is one of the most common craniofacial birth defects. Many genes are known to be involved in the etiology of this disorder; however, our understanding of cleft lip pathogenesis remains incomplete. In the present study, we uncovered a role for sonic hedgehog (SHH) signaling during lip fusion. Mice carrying compound mutations in hedgehog acyltransferase (
Hiroshi Kurosaka, Angelo Iulianella, Trevor Williams, Paul A. Trainor
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis and controlling autoimmune responses. On page 1027, Sanchez Rodriguez et al. demonstrate that a subset of Tregs with memory properties (mTregs) reside in human skin and further provide evidence that these cells are dysregulated in patients with inflammatory skin conditions.
JCI Impact is a digest of the research, reviews, and other features published in each month's issue of the Journal of Clinical Investigation.
Significant progress in the last 15 years has transformed the field of lymphatic vasculature research into a boom area. The relatively recent identification of specific growth factors and molecular markers that distinguish endothelial cells of the lymphatic and blood vasculature lineages were pivotal for this development. Given the almost ubiquituous distribution of lymphatic vessels in most organs, it is not surprising that this type of vasculature is actively or passively involved in a large number of human diseases. The reviews in this series aim to describe a number of emerging areas in lymphatic biology, including mechanisms that mediate lymphangiogenesis, the development of mammalian lymphatic vasculature, the genetics of lymphatic anomalies, new technologies for studying the lymphatic vasculature, and the role of lymphatics in disease, including lymphedema and cancer, and physiological processes, such as inflammation and immunity. Cover image credit: K.Pichler/CeMM/MedUni Wien/Josephinum (www.josephinum.ac.at).

subset: commoncrawl


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By Anastasia Donde
Tue Feb 8, 2011
The New York fund of funds was a top performer in 2010.
At a time when funds of funds are being criticized for mediocre returns and investors are pulling their money, New York's EnTrust Capital stands out for posting above average performance and growing its assets by $2 billion since 2008. Its flagship institutional fund of funds, the EnTrust Capital Diversified Fund, gained 11% in 2010, well ahead of the InvestHedge Composite Index, which rose 4.86%. Clients and consultants said the firm's profits stemmed from hefty allocations to credit, special situations and event-driven hedge funds—the best-performing strategies of the past year As of the fourth quarter, $5.5 billion EnTrust had invested about 42% of the Diversified Fund in credit hedge funds and 17% in special situations funds. The firm began building a sizeable allocation to credit funds in 2008 when spreads started to widen significantly, said Gregg Hymowitz, managing partner. "If you can earn LIBOR plus 2,000 basis points in senior secured...
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ODNR Division of Geological Survey 2045 Morse Rd., Bldg. C-1 Columbus, OH 43229-6693 Phone: (614) 265-6576 Fax: (614) 447-1918 E-Mail Location Map
Earthquake Contacts: 24-Hour Earthquake Reporting Hotline: 1-855-QuakeOH 1-855-(782-5364) Media Inquiries Phone: (614) 265-6860 E-mail Web Page
Origin Time: 11 December, 2005, 05:20:02.38 UTC Location: 41.95º N -80.84º W Magnitude: 2.0 - local magnitude (Lamont-Doherty Earth Observatory) Depth: 9.9 km (6.2 miles)
A small earthquake occurred beneath Lake Erie approximately 6 kilometers north-northwest of Ashtabula at 12:20 a.m. EST on December 11. One person on the west side of Ashtabula reported a loud booming sound. Individuals who felt this event are encouraged to report it at the link below. Earthquakes of this size do not cause damage but can be felt by individuals close to the epicenter. However, the shaking from such a small earthquake is commonly so minor and brief, that many people do not recognize it as an earthquake. The event occurred at the general location of a 2.5-magnitude earthquake in 1995 and a 2.0-magnitude earthquake in 2000.


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The problem as I hear it is with the Core i7 Lynnfield. You see for the most part when people think of Core i7 they will think LGA-1366 and X58. So the new Core i7 870 will seem to fall into that higher [and more expensive] category. However, while the naming is confusing, for us the performance differences were spot on and fit with the Intel marketing plan of putting the i7 870 as the high-end of the mainstream and dovetailing with the enthusiast level i7s.
In the pages below we will take a look at both the Core i5 and Core i7 Lynnfield CPUs. We will see how they perform at stock and what we can get from a quick overclock on air. Read on to see if this new CPU and chipset from Intel are worth your hard earned money.
What's NewThe biggest difference between Lynnfield and Nehalem [Core i7-900 series] is memory support. With Core i7 900 you get a full three channels but are limited to 1066 MHz for DDR3 support [at least that's the official line, which we all know is the other BS, opposite of Bright Side]. Lynnfield cuts the channel support back to two and increases the official memory support to DDR3-1333. The removal of the Triple channel support does change the socket as the pin count drops from 1366 to 1156. Not having triple channel memory will hurt memory intensive applications like rendering and in some case high-level computations. This is not a signification issue as Lynnfield is not marketed for those high-end applications but more for mainstream gaming and work.
Click to Enlarge
Core i5 will lose Hyper-Threading but will maintain all of the other features found in the Core i7 870 although it will have a much slower clock speed. All three of the 1156 Lynnfields will have 8MB of L3 cache, an integrated memory controller, and a 95 Watt TDP.
Lynnfield is also smaller, and more power efficient than both the 1366 Core i7 and the previous Core 2 Quad generation. In fact comparing clock for clock the core i5 is roughly 20% faster than a Core 2 Quad [i5 750 Vs. Core 2 Quad Q9400]. But the size difference is also important; Intel has moved the graphics controls onto the CPU. This means that your PCIe graphics are executed on the CPU rather than in the MCP or Northbridge. It allows for an overall reduction of silicone by about 40% compared to the older Core 2 systems.
Both the Core i5 and Core i7 LGA-1156 CPUs are very impressive on paper, they take some of the best features of the Intel Nehalem architecture and put them into a low(er) cost package. This should shake up the AMD claim that they have the best performance/price point. But as we have not covered performance just yet we cannot say that for certain.
Thanks for reading BSN*


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Results for keyword: Science
The Tree Coroners
To save the West's forests, scientists must first learn how trees die.
by Cally Carswell, Dec 16, 2013 -
On (not) being Jane Goodall
A writer wonders what it would be like to study the coati, a Southwestern cousin of the raccoon.
by Sharman Apt Russell, Dec 05, 2013 -
Cosmic Prospecting in Lead, South Dakota
What happens when an old mining town recruits a physics lab and pursues Big Science?
by Marshall Swearingen, Nov 19, 2013 -
Madame Merian and her passion for metamorphosis
In Chrysalis: Maria Sibylla Merian and the Secrets of Metamorphosis, Kim Todd uncovers the life and legacy of a pioneering 17th century woman
by Michelle Nijhuis, Jan 21, 2008 -
Letter imperfect
Some of the more heated responses to Ray Ring's gun story show a certain ignorance of general constitutional principles, but HCN loves letters and is already looking forward to readers' reactions to the current issue's story on carbon sequestration.
by John Mecklin, Sep 03, 2007 -
Scientists and the city
Scientists working in the relatively new field of urban ecology study cities like Phoenix, seeking to gain knowledge that will help all cities as the West gets warmer
by Petra Spiess, Aug 20, 2007 -
Super rodents build super habitat
In the Southwest's Chihuahuan Desert, prairie dogs and kangaroo rats provide food and shelter for a host of other animals.
by Morgan Heim, Aug 09, 2007 -
The clock is ticking
Robert Redford and Auden Schendler find it ironic that, under its current leadership, the Environmental Protection Agency could never qualify for one of the Climate Protection Awards it gives out.
by Robert Redford and Auden Schendler, Jun 04, 2007 -
Global climate change? Let's go shopping
Jim Stiles scoffs at the notion of saving the planet by buying so-called "green" products.
by Jim Stiles, May 28, 2007 -
The challenge of climate-change denial
Skeptics, even irrational ones, probably once had a useful evolutionary role to play in human communities, but in the face of rapid climate change, they are becoming a fatal obstacle
by Auden Schendler, May 14, 2007


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Profiles on Soap Opera Cast Members and Characters
All My Children's Most Unforgettable Weddings
A look back at the most unforgettable weddings on All My Children
Profile of Susan Lucci - Erica Kane on "All My Children"
Profile of Susan Lucci who potrays Erica Kane on All my Children. The profile includes personal and professional details.
Ex-'All My Children' Star Jamie Luner is 'The Perfect Boss'
Ex-All My Children's Jamie Luner stars in The Perfect Boss
Ex-'Days of our Lives' Star Victor Webster Takes Us into the 'Continuum'
Ex-'Days of our Lives' Star Victor Webster Takes Us into the 'Continuum'
'The Bold and the Beautiful' Star Winsor Harmon Heads to 'Cathedral Canyon'
Winsor Harmon talks about his passion project "Cathedral Canyon" after years on "The Bold and the Beautiful"
'One Life to Live''s Erika Slezak's Talks Victoria Lord & More
Erika Slezak Talks Her Return to "One Life to Live"
30 Facts About Young & Restless' Daniel Goddard
In this "Homefront" interview, James Franco talks teaching, why the role of Gator was appealing, and what it was like going up against Jason Statham.


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SINCE several reports have appeared in the media over the last several weeks that incompletely or inaccurately indicate the position of the United Mine Workers of America with regard to mountaintop removal mining, I believe it would be helpful for me to briefly outline our position.
The UMWA believes that strong protection for our environment is essential. As we have pointed out many times, our membership lives in the communities in which mining takes place and believes strongly that we have a duty to future generations to protect that environment.
At the same time, we make no apologies for seeking to promote the jobs available in mining and related industries. After all, these jobs average more than $50,000 per year plus benefits including retiree health care and pensions. West Virginia is already 49th in per capita income. We surely do not want to drive ourselves into an even more negative position.
Unfortunately, the debate has often been between two extreme positions - one calling for the abolition of coal mining and the other decrying any type of restrictions on mining companies as they damage peoples' houses and degrade local streams. We do not agree with either of these extreme views.
Some critics have suggested that the UMWA is only interested in the protection of our members' jobs when they work on mountaintop removal sites. Make no mistake, that is important to us.
As this statement of policy makes clear, however, we believe that this criticism is unfounded since we also believe in strong environmental and community protections. We do believe that jobs provided in coal mining are worth fighting for and preserving. This is particularly true in our economy, in which service sector jobs are often very low paying and without benefits. We are proud of our support for such jobs.
At the same time, we support strong regulatory efforts to protect the water resources of our communities, and we also believe that families living in these communities should be protected against blasting debris and the degradation of their communities.
We believe that coal companies should be held to a high standard of environmental protection and that the state and federal officials entrusted with that enforcement have on many occasions not sufficiently protected our communities.
In this regard, we support the comprehensive study of the long-term effects of mountaintop removal mining recently suggested by EPA officials, with West Virginia taking the lead in such a study and the consequent lifting of the ban on permitting.
The UMWA strongly believes that coal companies should not be permitted to destroy local communities in the process of mountaintop removal mining, including by blasting. Community residents with homes and farms should be protected from the consequences of such damage. Under current law, a homeowner can pursue a damage claim in circuit court. The practical problem is the cost of hiring attorneys and the litigation costs in hiring expert witnesses.
The UMWA believes that there should be additional legal protections to ensure that blasting damage can be easily and completely compensated by coal companies.
We suggest a statutory change so that blasting law would be made similar to a provision in state oil and gas law. Under the law, any damage to water supplies caused within 1,000 feet of a gas well is presumed to result from the drilling and operation of the gas well.


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Halloween Costumes
Adult Costumes / Mens Costumes / TV and Movie Costumes / Horror TV and Movie Costumes / Werewolf Adult Men's Plus Size Costume
Werewolf Adult Men's Plus Size Costume
Item# 07149925
It might be uncomfortable and itchy and scratchy to be a werewolf in real life but on Halloween you can capture the character in this classic adult men's Werewolf plus size costume and enjoy a painless transformation. The shirt is easy to wear, the mask is suitably scary with monstrous teeth and the paws are gloves so you can grab treats if you want.
- The adult men's plus size Werewolf costume consists of a red hunter plaid shirt with long sleeves, tattered cuffs and hem and a tattered chest cut out with plush chest inset, a realistic plush werewolf mask with resin teeth and matching werewolf gloves with plush cuffs
- Materials/ Fabrics- Gray Plush. Shirt Woven
- Wash/Care Instructions- Hand wash separately in cold water. Do not bleach. Line dry. Do not iron.
All Reviews
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Displaying Review 1 of 1Back to Top
Best costuume!!!
By Gm from New orleans la on 10/19/2012
Comfortable, Fun To Wear
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Yes, I would recommend this to a friend
Comments about Werewolf Adult Men's Plus Size Costume:
It is verry hard to find costumes in bigger sizes they normally only offer a costume in small or x small but I really liked the way this fit and it is a great buy I am so glad that I could find something in my size one of the best Halloweens I am going to have in years!!!
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Who wants rabbits, guiney pigs, monkeys killed for safety testing of cosmetic ingredients? Yet we are in 2011 and the industry is still trying to postpone the proposed March 2013 ban date. The aim of this date was to give time to to industry to develop alternatives to safety evaluation tests based on animals. Scientifically I am aware it is a big challenge, however they had several years to work on this and BUAV thinks that it takes far too long to approve new methods. There are new methods available, but it takes 2-3 years to approve them, why? the organization responsible for this, ECVAM, does not have enough resources to deal with the bureaucratic burden of it all!
What to do? Sign the BUAV petition (coming out in 2 weeks) where they ask to stick to the original ban date of March 2013, to save animals lives and to get governments to invest much more in the approval process.
Forest Secrets Skincare is cruelty free and approved by the BUAV


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Beauty Without Cruelty Ultimate Natural Mascara Walnut -- 0.27 fl oz
Nearly Perfect.
This is the best mascara that I have tried in a few years. I don't want my mascara to thicken or lengthen, I just want my lashes to be noticeable and for the product to stay on without flaking. This one hardly flakes at all and is not gooky or clumping. It also is easy to remove.
March 25, 2013
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Meditation has been practiced for thousands of years and has many benefits. During meditation, you increase your focus on the present — minimizing random thoughts of everything but the moment at hand. Meditation can help with concentration, relaxation, inner peace, stress reduction and fatigue. It may also help relieve anxiety, depression, pain and insomnia. When combined with conventional medicine, meditation may improve physical health, such as heart health, rheumatologic conditions and digestive problems.
There are many forms of meditation, but most have in common a quiet location, a specific comfortable posture and a focus of attention. The method often taught at Mayo Clinic is called paced-breathing meditation, which includes deep breathing.
Read more about meditation.
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"With this versatile recipe, you can whip a wonderful peach cobbler up with fresh, frozen or canned peaches. And the same basic recipe works beautifully for other berries and fruit. The only thing you have to remember is that when you spoon the biscuit batter and the peaches into the baking pan, don 't stir."
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Time-tested flavor combinations come together deliciously in this simple cobbler.
Turn fresh peaches into sweet, outrageously delicious cobbler.
Watch Chef John make a delicious but simple peach cobbler.


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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 618314, 2 pages
Functional Foods: Towards Improving Oral Health
1Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
2DIPTERIS, University of Genoa, 16132 Genoa, Italy
3Department of Microbial Diseases, UCL Eastman Dental Institute, London WC1X 8LD, UK
Received 24 November 2011; Accepted 24 November 2011
Copyright © 2012 Itzhak Ofek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
How to Cite this Article
Itzhak Ofek, Carla Pruzzo, and David Spratt, "Functional Foods: Towards Improving Oral Health," Journal of Biomedicine and Biotechnology, vol. 2012, Article ID 618314, 2 pages, 2012. doi:10.1155/2012/618314


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01. Derek Pitral & Rob Kipara ? Formation (Original Mix) 02. Derek Pitral & Rob Kipara ? Class XII (Original Mix) 03. Derek Pitral & Rob Kipara ? Gas and Dust (Original Mix)
The @DJTristanCooke 'UK Psychedelic' compilation is available once again on our website in both WAV and mp3.
UK PSYCHEDELIC ? compiled by Tristan
UK PSYCHEDELIC ? compiled by Tristan
Tristan, the internationally acclaimed juggernaut of the psytrance familia has compiled a scorching selection of tracks from the best of UK psychedelic producers.� Featuring the likes of Avalon, Dickster, Laughing Buddha, Raja Ram, Aphid Moon, Master Blasters, Sonic Species, Sybarite, Nigel, Magik, K.i.M and of course Tristan himself, this collect...
Ektoplazm welcomes cryptocurrency donations
Ektoplazm is a community-supported free music portal serving terabytes of MP3 and lossless CD-quality audio each and every day. I have been working hard to provide an alternative to the traditional for-pay distribution system since 2007, volunteering countless hours of my time to provide independent labels and artists with a platform to share their music ...
Uptrax Records * uptrax008-2 * Various Artists * sunshine live Mix Mission 2013 * Dance * 2013-12-20 * 2CD
The year is going to its end.. but wait! We still have a very special mission to complete! The Mix Mission 2013 - starting on December 23rd 2013 at 6pm, the yearly Mix Mission will last for 10 whole days on Germanys No.1 electronic music radio sunshine live. This means in concrete terms: 246 Hours of nonstop live mixes from A-Class Top DJs as well as newcomers and regional scene heroes - live and direct, without a break from the broadcasting studio in Mannheim, but also from the hottest club and event spots of sunshine lives transmission area! And for completing the mission, a brand new mixed double album will be released this year again: 2 exclusive DJ mixes including the hottest tracks of the Mix Mission 2013! Compiled and mixed by sunshine live DJs Chico Chiquita and DJ Falk. Mix Mission 2013 - the year will be HOT once again! http://www.humpty.de?id=47&aid=30380&lang=en
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Our Spa name is borrowed from the Latin aborēscēns, relating to the characteristics of a tree. More than just symbolic, the Arboressence Spa, while adjoined to the hotel, is set among native pines, and features exposed timbers in its design and decor. The outdoor four-season hot tub sits beneath a forest canopy, while providing a view of the lake through the trees. Indeed, Arboressence is the right name.
The Spa is also the right choice for anyone looking to recharge, regenerate or simply indulge. Our expert technicians offer a range of signature treatments and therapies, applying the renowned Phytomer product line of skin and body care products. A stone hearth and comfortable sitting areas add to the nurturing ambience.
The Spa is open to hotel guests and the general public alike by appointment. A sample menu is provided at left.


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a place for zinesters - writers and readers
I've been looking around online and it seems that Brighton doesn't have a Y to stay at. Nor does it have a hostel that's a member of the YHA. Does anyone know of anywhere in Brighton that will let people stay for little or no money? Is anyone here on CouchSurfing, or prepared to let me crash on their sofa in return for zines and vegan cookies and cake? Someone at London Ladyfest joked that I could stay at hers, but since I didn't get her name... xP
Anyway, really looking forward to BZF, it's gonna be rad!
68 members
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Ist preference given to distros and zines. Rates and details are here. Limited space. Very Low Cost!
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Rice Croquettes
Comment on this recipe
1/2 cup long-cooking white rice 2 cups milk 3 eggs 1/2 cup sugar 1/2 teaspoon salt 1 teaspoon butter 2 eggs, beaten 20 saltine crackers, crushed on wax paper 2 cups canola oil
Cook rice and milk in 2-quart saucepan over medium heat, stirring frequently, until rice is tender (about 45 minutes). Add 3 eggs, sugar, salt and butter. Remove from stove, let cool. Chill in refrigerator for 24 hours. To make croquettes: Shape 1 tablespoon of rice mixture into an egg-shape. Dip into beaten egg and roll in cracker crumbs. Fry in oil at 325 degrees until light brown on all sides, about 3 minutes. Serve warm. Makes 16 croquettes.
Kristin Miller Bettendorf
Escalloped Carrots (More recipes)


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3 Pack Swiss Tech Solar LED Flashlight Keychain
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Posted: 10:40 p.m. Friday, Jan. 3, 2014
By Christine Slusser
Video transcript provided by Newsy.com
This week was full of stories that made our hearts swell with happiness, so we've picked our top three heartwarming stories of the week. Let's get this love wagon rolling.
Our third pick is all thanks to the Make-A-Wish Foundation. An 8-year-old boy with cerebral palsy really wanted to hang out with the NBA's Memphis Grizzlies team. So they made that happen. (Via WREG)
"They decided to draft 8-year-old Charvis Brewer. He said it was his dream to be a member of his favorite basketball team. The Grizzlies had a nice little news conference with him yesterday. They gave him a contract, and of course they gave him a draft hat." (Via HLN)
Charvis also went to a game and became the youngest player ever drafted into the NBA. Congrats, bud! (Via WMC-TV)
More Popular and trending stories
Next we have a man who was truly in the giving Christmas spirit. Businessman Jonnie Wright dressed up as a homeless man, and any time someone gave him money, he handed them an envelope that read: (Via KCCI)
"'I'm not homeless, I'm not destitute and I'm not without a job.' Also tucked inside the envelope, a $10 bill. And the letter went on to say, 'Keep it, spend it, pay it forward, whatever your heart tells you to do.'" (Via WBAL)
Wright's message was simple: It's better to give than receive. He also donated all the money given to him to charity. Pretty awesome. (Via KTVH)
Our top pick of the week involves 12-year-old Jaxxyn Wood, who is credited with saving his entire family's lives. He was playing video games when he noticed something wasn't right. (Via WAVE)
"I was sitting there, and I smelled something really bad, like Legos on fire or something."
"Jaxxyn is the youngest of 11 siblings and was the only one awake while eight others were sleeping." (Via WKYT)
Jaxxyn woke up his sisters, and they helped wake up everyone else in the house.
Thankfully, the entire family made it out alive. He said he learned what to do because a firefighter taught his class at school. Investigators believe an ice machine malfunction caused the fire. (Via WLKY)
Thanks for watching Newsy's top three heartwarming stories of the week. Be sure to check back next week for our latest top-three list.
See more at: Newsy
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Get a taste of the iPhone (sort of)
A downloadable color skin for the Razr mimics the iPhone interface.
And here you thought the Apple/Motorola marriage was no more. If you're frothing at the mouth for Apple's iPhone and can't wait until June to get your fix, there is a way (for the moment at least) to get a taste of what's to come. Macsupport is linking to a download for Motorola Razrs that installs a skin of the iPhone menu interface for the phone's display. Granted, it won't magically turn your Razr into an iPhone but if you want that Apple taste for a few months, it may just do the trick. We don't expect Apple's lawyers to take kindly to it though, so be sure to get it while the getting is good.


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Washington D.C./Baltimore Olympic bid coming for 2024?
BALTIMORE (AP) - An organizer of the Washington-Baltimore area's unsuccessful bid for the 2012 Summer Olympics is considering putting a bid together for the 2024 games.
Dan Knise was president and CEO of the Washington-Baltimore 2012 Regional Coalition. He tells The Baltimore Sun that he's had "informal discussions" about making another run at the Olympics.
Several people involved in the 2012 bid and local political figures say they would support another bid by the region, although none had spoken directly to Knise.
Baltimore Mayor Stephanie Rawlings-Blake says the city "would do a phenomenal job" hosting the games.
The process of putting together a bid would include putting together a coalition, identifying sponsors, raising millions of dollars and submitting an application to the U.S. Olympic Committee.
Would you like to contribute to this story? Join the discussion.
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The dynamic interaction promotes a natural stride for a more efficient and responsive walk in these Skechers GOwalk shoes. In navy.
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- Resalyte midsole offers lightweight cushioning.
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Shoe Construction
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Shoe Details
- Round toe
- Slip-on
- Padded footbed


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Quoteable quotes from Reboot 9.0
Before I file away (or accidentally lose) my
(Note that the number of notes taken… or whether in fact any notes were taken at all, is not proportional to the interestingness of the talk. I didn't take any notes on
Further note – these people said many more interesting things than what I noted down… in fact… it's quite possible that some of the most interesting ones didn't get noted down because I was too busy listening to what they were saying :)
Opening talk –
We should be more interested in artificial emotion than artificial intelligence
Emotion is governed by meaning and value, which makes it more efficient than a computer (less heat coming off the tops of our heads!)
Emotions are more efficient than intelligence
People will accept losing money to ensure fairness. We don't want to lose money to a computer tho', as we know it is not vulnerable to the idea of fairness.
The gift economy is about to dominate the market economy [I wrote this down and put a big question marke next to it because Tor didn't go on to explain where this gift economy was coming from... have I been missing out on an avalanche of gifts lately or something? Anyone know more about this?]
Roszak 1979 Person/Planet – the needs of the planet are the same as the needs of the individual. If one is in crisis, so is the other.Flow – we are like flames, or riveres, or flows of things. We are not 'things'. We are a system.
90% of the atoms in your body are replaced every year
Permanent reincarnation – the matter changes all the time but we retain our identity. (Like digital media – never lose the information).
Dare, Share, Care —> Attention —> Sex, Jobs, Recognition
'Sex is the origin of all that is noble'
The killer app for Civilization 2.0 is links.
Albert Einstein – 'Remember your humanity and forget the rest'
Trusted Space -
A legion of men may look like a machine, but it is built on an intense social unit (a tent of 8 men who live together for about 20 years) and nodal leadership (the centurians).
We are most hapy in a group of approximately 7 or 8.
Twitter is like being 'in the tent'
Kids who do well are kids who learn 300 words by 2yrs old. They learn via conversation and need to have heard 50 million words by 2 yrears. They need to hear conversation to get an ideal development trajectory.
While we wait for the BabelFish –
Mario Wandruszka 'Being human among humans means living in a state of ever incomplete multilingualism'
People who are 'somewhat multilingual' are in the majority
We need more than binary on/off choices when it comes to language
The internet is a space cruncher – access isn't the problem any more, language is. The really strong borders are the linguistic ones.
Some multilingual people act as bridges – how can we design tools to better support them in this task?
Linguistic groups are more relevant than countries – misconception: country does not equal language.
Currently, the internet encourages mono-lingual silosCode-switching – switching between languages to choose the best expression from the languages available to you
Contact: Fuck off, come closer –
Experiment where you have a baby and a mother, and you put them in two different rooms with a video link. The mother does what mothers do… mirrors the baby's talk and actions back – baby is fine. Add in a 2 second time delay. Baby freaks out.
The Uncanny Valet –
What we're building on the web today is defining the manners of the web for the future
Agents make people diminish themselves 'anthropological representations destroy [users] sense of accomplishment (eg. MS Clippy)
Computers as social agents – we treat them like people
The illusion of control (which we want to create) is esp. hard to convey to new users
The principle of least astonishment – avoid surprises in the interaction, avoid 'breaking frame' etc.
Desktop manners are inappropriate on the web [anyone want to discuss this? I think this is related to the whole 'design uncanny valley' which I think is far too broad a generalisation... ]
Forgot to write down who said this…. anyone remember?
Not trusting is inhumane. It paralyses you.
'Trust is a reducer of social complexity' [who said this?]
(note to my elearning friends, if you're still out there – you *definitely* want to know about this guy if you don't already!)
Kids are used to having large audiences
Kids are 'genius level' at creativity when they enter school. Only 2% remain at this level when they leave school.
Kids want authentic goals – why do we have to do this? They need to have an authentic purpose
Some *great* examples of using existing platforms to support learning activities eg. Flickr for art appreciation, Choose your own adventure games built using Flickr and links.
At the moment, the mobile phone is the most powerful technology we have in schools – why don't we use them more?!
'for a period of time these websites *where* the town'
power of virtual communities to reclaim and rebuild physical communities.
what young people use their mobile phones for (in order of use) – a) clock, b) TXT c) calling
I wrote a bunch of stuff based on what Stowe said earlier. Also:
Time is a shared space
Productivity is second to connectivity
Don't worry if you miss something the first time – the network will repeat it. You don't have to be a slave to the flow of traffic.
Food for thought. A couple of days well spent. :)


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What is in this article?:
When it comes to probation, some organizations just come unraveled. They lose their staff, their funding, or both, and they just can't bring about across-the-board compliance. The rest tend to be organizations that haven't learned from their past mistakes, says Kopelow. They were found out of compliance the last time they came up for accreditation, received a progress report requirement, fixed the problems, and then two years later are found to be making the same mistakes. That's not fair to the other providers, Kopelow says.
This is the third in a three-part series on the ACCME accreditation process for CME providers. The first details the ACCME's accreditation process. The second provides tips on achieving Accreditation with Commendation.
You May Also Be Interested In:
42 Tips on Surviving the ACCME Review
New Publication Outlines Everything You Want to Know about the ACCME
ACCME Expands Education and TrainingACCME Surveys First Round of Providers Under New Criteria
New Criteria Pose New Challenges


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See other Curitiba properties
Curitiba Backpackers Hostel
Real Reviews
Real reviews from fellow travellers
These are trusted reviews from guests who have actually stayed here. We hope you find them helpful.
Note: we only give a property a rating once it has received a minimum of 3 reviews.
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- " Great value for your money, the staff are really nice and the location is not bad. They have a kitchen you can use, a living room with TV and cable, wifi (although it doesn't work in some rooms) etc. When I return to Curitiba I will stay there again. :) "
- 18 Dec 2013 Anonymous Brazil
- " Wonderful staff! Friendly guest! Decent place to stay! 10-20 min walk to some of places: supermarket, restaurant, downtown. I'm lazy, so that is too far. hehe "
- 09 Apr 2013 Anonymous Trinidad And Tobago


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The best music and talk stations
Playlists for any mood or activity
Custom radio by artist or song
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Japandroids are an indie garage rock duo from Vancouver comprised of Brian King (guitar) and David Prowse (drums), who share singing duties. Founded in 2006, the band self-released a pair of five-track EPs, All Lies (2007) and Lullaby Death Jams (2008), before making its full-length album debut with Post-Nothing (2009) on the Canadian label Unfamiliar Records. Though Japandroids were more or less unknown at the time of their album debut, Post-Nothing got a big boost from the tastemaking website Pitchfork, which championed the album as one of its "Best New Music" selections. In 2010, Polyvinyl released a compilation that lumped together All Lies and Lullaby Death Jams, titled No Singles. This singles-mindedness continued in 2011 as the band released a series of 7"s in five installments. ~ Jason Birchmeier
ALT 98.7 Los Angeles LA's Alternative
Celebration Rock
No Singles
Sleigh Bells
Cloud Nothings
Titus Andronicus
Surfer Blood


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4.3 out of 5
18 Reviews
I love it!
October 15, 2011
I just love what i bought! The jacket is so cool! The color was also as i wanted bright white! Theres just no word for it but AWESOME! I would really recommend this site also because it's trustable.
Pros: Great design, Build quality, Lasts forever, Great valuewarm and fuzzy!
April 16, 2013
I got this so i would have another jacket to wear in pictures. it's super warm and comfy. I like all the pockets and the fur hood. It seems like its made with a durable material too. i'm 5'2 and about 140. I bought a medium and it has enough room for layers underneath
Pros: Build quality, Performance, Ease of useJanuary 13, 2014
I love the fashionable street style of the jacket. Great for apres ski. Haven't used it yet on the slopes, so I can`t comment on its performance. Very satisfied with Altrec service. Would recommend to a friend.
Pros: Great design, Build quality, Great valueGreat jacket...but it's purple
January 09, 2011
The Burton Tabloid is a great jacket. I tried my friend's Tabloid on the slopes and liked it's warmth (I didn't need to layer a bunch of other clothing under it) and style. I especially appreciated the slim fit and the way the jacket was a bit longer than normal, extending a few inches below my hips. After riding with my friend's jacket, I decided that I had to have one. I ordered the jacket in Royal Pain, which looked blue on the website. Upon recieving the jacket, Royal Pain is definitely purple. Other than the color, I have no complaints about this jacket.
Burton Snowbord Jacket
October 10, 2012
Its an awesome jacket. I live in Alaska and I would wear it on warmer days and in and out to the car but I wouldnt use it out hunting or in -0 weather. I love this jacket !!!
Pros: Great designNovember 06, 2013
Jacket is cute and comfortable! Haven't had a chance to use it yet, but will in a few weeks. Bring on the snow!:)
Pros: Build quality, Great valuethis jacket is awesome
March 06, 2011
This jacket is very stylish yet durable. It will keep you dry and warm. I used this jacket at tahoe and it was great! Everybody loved how it looked like a womens jacket.
January 01, 2012
I love this jacket. I wore it snowmobiling and got tons of compliments on it. It has a slim fit and it still just fun and cute. I like all the pockets and feel like it's a very functional coat. The fur makes it kind of trendy and fun as well. Overall, this has been a great little coat.
Awesome coat!
December 05, 2011
I bought this coat for snowbaording and I love it! It is true to size, warm and comfortable. The only minor issue I have is the grey inside of the coat ( I would prefer all black). Other than that, it is an awesome form fitting jacket that allows a female to be cute while snowbaording!!
Cute jacket!
December 31, 2011
Very cute jacket! Fits great. Wished the liner was a better color rather the grey and pinstriped hoody with the white. This website is great! Fast delivery!
February 20, 2011
I picked this jacket because I thought it would fit me well...I am tall and slim and so I liked the long arms and slim fit aspect. Unfortunately, the waist ends up making my body look like an apple (huge midsection) and the shoulders are very broad and masculine. Dislike. Maybe it will work well for other body types, but it was very unflattering on me.
Nice Jacket if Fits Right
May 08, 2011
Very happy with price, immediate service from Altrec and quality of garmet...waterproof, well insulated and attractive purple color. Removable hood also a nice feature. Unfortunately, the sleeves are so long (rarely a problem for my long arms) and the bottom elastic feels snug on the hips. Would recommend for a tall thin build with long limbs. Will return this one.
Fashionably Cute
January 25, 2012
I live in WNY, as you may know, the snow and freezing weather is no joke! So I wanted a fashionable coat, that's warm...but not bulky..this is perfect. I'm 5"5 175lb and very curvy, and Xl in Black is awesome, I definitely recommend Alrec for out wear. You will not be dissapointed!
Pros: Great design, Ease of use, lots of pockets, Cons: Costso durable and warm
October 28, 2011
i wear this coat for biking in the night and early mornings and it really does the job, all by itself too. i dont have to wear any layers underneath the coat in 30 degree temperatures (while moving around). it is large enough to be very protective and to do layering. but surprisingly, it is also cute. my boyfriend says i look like a princess when i wear it and my grandma is going to go buy one of her own now! for the reduced price, and the lifetime warranty included, i am very happy about my purchase. if i find cons about this coat, i will rewrite my review pronto!!
Pros: Great design, Build quality, Ease of use, Great value, you'll look like a princess, your grandma is gonna make get one tooDecember 20, 2010
I chose this jacket because of the Thermacore Insulation [100G / 60G Sleeves]. I don't like feeling bulky with layers, and I can wear this with just a thermal longsleeve or maybe tshirt. I got the Black Gingham and love it, looks way cooler than just a solid color!
Warm jacket/coat
January 09, 2011
I received this coat about a month ago in hope of replacing my 15 year old North face winter coat. At first glance I fell head over heals in love with the "Olive green" color - It happens to be even more lovely in person. As far as fit goes, I am 5'7" and have a oddly shaped mid-section, lets just say I have larger love handles and no hips, apple shaped type. My pants have a tendency to fall down and shirts have a tendency to ride up. Before owning this coat I had no experience with a jacket with a cinched/fitted waist. I usually wear medium to Large in tops and made sure I ordered a Large to accommodate for the fitted waist. I love the way this coat fits. It happens to hit me at just the right length to stay down even when reaching for things, which was my only worry when purchasing this particular coat. The sleeves are also super long which I love.
Totally cute
December 20, 2012
The spruce color is amazing - and it has a very fine, almost plaid-like pattern. It is a slimmer fit, which I love. It hugs where it needs to, but is loose and moves where you want it to. The fur-lined hood is an added bonus! I can't wait to try it out on the slopes!
Pros: Great designTabloid jacket
August 11, 2013
I always find it hard to find a jacket that is not only durable but also looks groovy, The burton tabloid nails both, the only hard decision is with colour to pick, and that's why a bought 2.
Pros: Great design, Build quality, Great valueBurton Women's Tabloid Snowboard Jacket Photo
Bright White, Canvas Prepster Plaid, Hex/ Heathers Liner, Olive, Olive Radiant Plaid, Palette Stripe Print/ Hex Liner, Spruce/ Hex Liner, Tart and True Black.
Available sizes, while supplies last, include size xxs, size xs, size small, size medium, size large and size extra large: xxs, xs, s, m, l, xl.