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Home | Directions | Hours | Rates | Instruction | Camps | Groups | Parties | Contact Us
© 2013 Atlanta Rocks! Intown
1019 Collier Rd NW, Ste A
Atlanta, GA 30318
Rates — Daily Climbing | Boulder Only | Term Memberships | Punch Card | Discounts | Rental Gear
Hours — Mon-Friday (11 am-10 pm), Saturday (12 pm-8 pm, Sunday (12 pm-6 pm)
Directions — 1019 Collier Rd NW, Ste A, Atlanta, GA 30318 | 404-351-3009
Event Calendar — View a complete list of Special Events on our Monthly Calendar
Intro to Gym Climbing Class (12 and up) — During the intensive workshop, participants learn basic climbing techniques, knots, belaying, climbing signals and the proper use of harnesses and other climbing equipment.
Technique I (12 and up) — Technique I focuses on climbing movement and balance — perfect for new climbers looking for a way to get started and for more experienced climbers looking to fine-tune their skills. No previous climbing experience is needed.
Technique II (12 and up) — Technique II builds on the foundation of Technique I, by expanding on movement and balance while also dealing with efficient use of different hold types, grip types, friction and body tension. Climbers should have several months of climbing experience before taking this class.
Intro to Gym Leading (18 and up) — The lead climbing class is designed to teach lead climbing and belay techniques specifically for the indoor gym environment.
Parties — Atlanta Rocks! is a terrific venue for a birthday party (young or old). No prior climbing experience is necessary. (Reservations, Waiver, Day of Party, Goody Bags, Party Invitations)
Overnight Lock-Ins — Atlanta Rocks! presents, the kind of all-nighter everyone will enjoy!
Groups (10+ Climbers) — Atlanta Rocks! is ideal for exclusive private functions birthday parties, corporate events, Bar/Bat Mitzvahs, sweet sixteen parties, scouting functions and youth outings. No prior climbing experience is required.
Novice Climb – Novice Climb (one or more climbers) is a two-hour, special supervised program for all ages. No previous climbing experience required.
Team Building Atlanta Rocks! will customize your event to meet your needs by providing as much or as little structure as you desire. A typical program might feature an exciting mix of rock climbing activities which foster cooperation, communication, and teamwork while challenging attendees to achieve goals which may initially seem improbable or impossible.
Parties — Atlanta Rocks! is a terrific venue for a birthday party (young or old). No prior climbing experience is necessary.
Atlanta Rocks! Alerts are sent to subscribers periodically via e-mail. These Alerts may contain time-sensitive information, important announcements, or special offers that you won't want to miss. Stay informed with Atlanta Rocks! Alerts.
Atlanta Rocks! Perimeter — The first indoor climbing gym in Atlanta.
Outdoor Climbing Links — The varied geography of the southern United States has given rise to some of the most interesting and varied rock climbing in the world. Descriptions of, and driving directions to, many of the most popular climbing areas in the southern U.S. are provided courtesy of Chris Watford, author of The Dixie Cragger's Atlas, the authoritative guide to southern rock. The Dixie Cragger's Atlas provides extensive route information and is the ultimate source for any outdoor climbing enthusiast.
Skyhoundz — The Center of the Disc Dog Universe.
Hyperflite — Manufacturer of discs for dogs and training materials.
Quick Climb — No Experience or Reservation Necessary
School of Rocks! — After School Program
Summer Rocks! — Afternoon Program
Atlanta Visitors Bureau Video — The Atlanta Convention and Visitors Bureau produced a series of TV commercials, collectively entitled, This is our Atlanta, to promote the city of Atlanta. The band, Collective Soul was featured with Atlanta Rocks! as a backdrop.
Atlanta Rocks! Alerts are sent to subscribers periodically via e-mail. These Alerts may contain time-sensitive information, important announcements, or special offers that you won't want to miss. Stay informed with Atlanta Rocks! Alerts. Sign-up here.
Who let the dogs out? Well, probably you if you're the typical climber! We know climbers love their dogs and so do we. That's why the owners of Atlanta Rocks! founded a canine-centric company called Hyperflite. At Hyperflite, we make the Jawz disc — the world's toughest canine competition disc. You can purchase genuine Hyperflite discs at Atlanta Rocks! Fly high, bite hard!
See the best disc dog teams the world has to offer...Hyperflite Skyhoundz World Canine Disc Championship, Chattanooga, Tennessee, September 28-29, 2013. For further information, please go here.
Please click here to visit Atlanta Rocks! Facebook page!
If you would like to be a follower of Atlanta Rocks! and receive occassional updates, aka, Tweets, please register online here.
Active Atlanta Climbing Club members receive a discount of 20% for daily climbing and climbing memberships.
Active Southeastern Climbers Coalition members receive a discount of 20% for daily climbing and climbing memberships.
Atlanta Rocks is pleased to introduce a Boulder Only rate of $10 (tax included) during the week and $12 (tax included) on weekends. We also offer a Boulder Only One Month Memberships for only $50. Boulder Only means no rope climbing of any kind, and climbing no higher than shoulder level throughout the gym.
First Monday of the Month
In addition to our regular Ladies Climbing Night every Monday night, on the first Monday of the month we will now offer women 1/2 price Intro to Gym Climbing Classes. Reservation Required.
First Tuesday of the Month
The first Tuesday of every month, we will offer members who bring a partner, free climbing, and daily climbers, who bring a partner, will receive two-for-one climbing (must know how to belay or be belay certified).
Atlanta Rocks! was featured in the Spring edition of Men's Book Atlanta in its Now in Atlanta Section: Altitude Adjustment (by Molly Dickinson), Five ways to get above it all (here).
City's Best Atlanta Playtime Spots for Atlanta's Adults — Atlanta Rocks! Intown: For many adults a favorite past time as a child was climbing on anything and everything you could get your feet on. At Atlanta Rocks! feel free to get your climb on without having to worry about a harsh scolding from mom or dad. It's an indoor playground for all ages.
Climbing is a natural instinct that all of us share. You start to develop it as a child as you climb trees and fences, says Atlanta Rocks! general manager David Turrentine. But as an adult we might get arrested if we start hanging out in trees!
So Atlanta Rocks! is a special place where big kids"can basically let loose and enjoy a unique experience.
Atlanta Rocks! has proudly served the community of climbers, without regard to race, sex, religion, creed, color, nationality, disability, or sexual orientation, since 1994. To celebrate Black History Month, we thought Atlanta Rocks! climbers might be interested in this profile on AR Climber Dexter Gilbert. Enjoy!
Dexter Gilbert, 40, of Atlanta, is just like any other rock climber that you might see scaling the walls at Atlanta Rocks! Indoor Rock Climbing Gym in Midtown, Atlanta. He's into sports and motivated by a desire to seek new challenges. But, for Gilbert, climbing, in his own words, is "about four times as hard," as it is for most other climbers. To the casual observer, it's not instantly obvious why that's so. At six-feet tall, with an athletic build, Gilbert seems like he would be made for climbing. And then you notice that Gilbert is blind.
Gilbert, who lost his sight at the age of six, first became interested in climbing while watching a gentleman talk about his experiences climbing Mount Everest on the Oprah show. "I did research on him and decided I wanted to try it, which led me to Atlanta Rocks!," Gilbert says matter-of-factly.
At Atlanta Rocks! Gilbert didn't get any special treatment because of his disability. He was required to pass the same belay test and attend the same introductory class as sighted climbers. When asked about the reaction at Atlanta Rocks! when he walked in the door, Gilbert — who attended the Intro Class with a friend — notes that they "handled it well."
Peter Bloeme, Atlanta Rocks! Co-founder, recalls the first time he saw Gilbert walk in the gym. "My first thought was that he must really be lost," Bloeme says with a smile, "but then he approached the counter to check in. I pulled up his record on the computer and, sure enough, he was approved to climb and belay. After watching him climb, I was impressed at how deliberately and gracefully he moved despite not being able to see the holds he was reaching for."
Session 1 - 6/9 - 6/13
Session 2 - 6/23 - 6/27
Session 3 - 7/7 - 7/11
Session 4 - 7/14 - 7/18
Session 5 - 7/28 - 8/1
To download Atlanta Rocks! 2014 Summer Camps Brochure, please click here. For more information on Atlanta Rocks! Summer Camp, please go here.
Atlanta Rocks! was a donation site for Toys For Tots this year and we would like to thank all the generous people who helped fill our two bins.
Each year, boys and girls from all around Atlanta try out for the Atlanta Rocks! Youth Climbing team. Of those, a select group is chosen ranging in age from 9 to 17 to represent Atlanta Rocks in the competitive youth climbing world. When we first introduced the idea to our customers in 1995, we knew of no other organized teams in the United States. Many of our youth team members have competed nationally since then. We have had several members rank in the top 10 in their age group and one national champion. (more)
Climbing builds self confidence and enhances both teamwork and self-reliance. Climbers learn to control their bodies and solve complex physical challenges by using their brains as well as their muscles. The social and athletic skills acquired through climbing will provide a lifetime of enjoyment. Youngsters are supervised by Atlanta Rocks! staff and will have ample time to develop friendships with other School of Rocks climbers. Parents are encouraged to relax in the gym, or get some work done, while their kids climb (Free Wi-Fi). more...
If you do not need any staff assistance, make the most of your lunch-time break with Atlanta Rocks! new rock climbing Power Lunch.
From 11 am-2 pm, Monday-Friday, you can climb or boulder at Atlanta Rocks! Intown Rock Climbing Gym and save big (Climbing $10/Bouldering $5)! From Atlanta Rocks! comfortable elevated-mezzanine area, you can contemplate your next climb while you're wolfing down your pastrami on rye (hold the mayo). Our free WiFi means you can send a quick suck-up e-mail to your boss before you gorge on more than 100 delicious climbing routes. When you hunger for more, come feed your inner beast;…at Atlanta Rocks!...At Atlanta Rocks!, we put the lunge in lunch.
Family Day, held every Wednesday!
Families that play together — stay together! And what better way to play than at Atlanta Rocks! Family Day? At Atlanta Rocks!, not only do we have affordable memberships for families with climbing in their blood, we've also got a day dedicated to everyone who wants to have a great family experience.
Family Day is held every Wednesday from 11 am-10 pm.
Read an informative story on Family Day from the Field Trips with Sue segment on CBS Better Mornings Atlanta here.
Enjoy live music while getting your Climb On! Rockin' at the Rocks! will be held on select Tuesdays and Thursdays throughout the year. Music from bands such as, "The Nate Condrey Band," "The Rockaholics," the "Haley and Alexis Band" and others! Blues, Indie Rock, Bluegrass, Punk, and Pop.
Please click here to visit Atlanta Rocks! Facebook page!
Please click here to visit Atlanta Rocks! Yelp page!
Important! — In order to provide you the best climbing experience, if you do not know how to belay, please call us for reservations at 404-351-3009. We will be happy to discuss all your climbing options, based upon your experience, at that time. With a reservation, our Novice Climb program is a great option for those with no climbing experience.
Atlanta Rocks! USA Climbing local competition results here.
On Friday, February 8, 2013 Atlanta Boxer Rescue held "Climbing for a Cause" at Atlanta Rocks! The event rasied over $1,000 for the rescue organization and two adoptions were finalized. Thank you all for your support. For further information on Atlanta Boxer Rescue, please go here.
Short introductory climbing video shot at Atlanta Rocks! by our friends at Brown's Guides.
This season The Real Housewives revisited Atlanta Rocks! and Porsha Stewart and her sister climbed here. Photo of Porsha (right), sister (left) with General Manager, David Turrentine (center).
A few season's ago premiere of The Real Housewives of Atlanta had a segment that was shot at your favorite climbing gym, Atlanta Rocks! Photo of Kandi Burruss and Peter Bloeme.


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Trash Bin Scare Prank His buddy gets quite the scare once he comes around the corner. 2/6/2014 11:04:20 AM 7,267
Street Performer Bucket Drummer Interrupted By Idiot Some idiot dives into his buckets while he's playing for the crowd. 12/29/2013 11:45:57 AM 13,797
Trash Bucket Rocket This is what you get when you explode fireworks under a trash bucket. 9/28/2012 12:00:00 AM 12,560
Strongest Girl In The World Prank The adults are dumbfounded that she can carry those buckets of change and they can't! 8/8/2012 12:00:00 AM 26,024
Kyle Gets Buckets 2.0 Blue Devil graduate and national champion Kyle Singler gets buckets on the campus of Duke University. He pulls off some pretty amazing trick shots! 5/24/2011 12:00:00 AM 26,023

subset: commoncrawl


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Cheap hotels in Piazza di Spagna, Rome
Neighborhood Description
Just south of the Villa Borghese and northwest of the train station, the Piazza di Spagna is home to the famous Spanish Steps, where hundreds gather to relax in the afternoon sun before strolling along the boutique- and café-lined Via dei Condotti.
The area is home to the Trevi Fountain, the lovely Villa Borghese Park, and loads and loads of stylish (and pricey) shops. Not surprisingly, the Piazza di Spagna area is considered to be a very desireable place to stay. This means that it's not exactly a bargain-hunter's paradise.
Sort By: Name Price Type User rating Most viewed
Address Via di San Basilio 55 (Piazza di Spagna)
The seven-room Daphne Inn Veneto is a splurge-worthy three-star property with decor as chic as its location between the Via Veneto and the the Spanish Steps.
No online booking
2Hotel Boccaccio
starAddress Via Del Boccaccio 25 (Piazza di Spagna)
The centrally located Hotel Boccaccio is homey one-star property with eight no-frills rooms and a fantastic location on a small cobblestoned street amid many restaurants and cafés.
3Hotel Panda
starAddress Via Della Croce 35 (Piazza di Spagna)
Situated just a two-minute walk from the Spanish Steps, the Hotel Panda is a great budget find with a fantastic location and clean, welcoming rooms.
4Hotel Suisse
starAddress Via Gregoriana 54 (Piazza di Spagna)
Situated in a historic palazzo just a few steps from Piazza Spagna, the three-star Hotel Suisse has been in the same family for three generations.
starAddress Via Della Purificazione 42 (Piazza di Spagna)
The Hotel Modigliani is a splurge-worthy three-star hotel with a four-star feel and an enviable location between the Spanish Steps and the Trevi Fountain.
Address Via della Croce, 41 (Piazza di Spagna)
(CLOSED) The Pensione Jonella is, sadly, no longer open.
No online booking
Check Rates for Checking Rates for No availability
xNote: This hotel does not offer online booking through our reservation partners. To see all available hotels in , please search below.


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I hope you've been paying attention to all those celebrity chefs on TV as you've got some point'n'click cooking to do in Esklavos C7. Pass me the balsamic vinegar... [subbed by Mantari, vmklover, She-Nomad & higgo].
NOTE: When I tried playing this it took a few attempts to get it to load due to the large number of people trying to play. Persist if you don't get it to load first time, it's worth it.
Entry 2923, Tuesday, September 25th 2007, Filed In Games
Rating(78%) Comments(56)
Wogger Mini 83 [subbed by Sentinel, some1 & anon].
Entry 2921, Sunday, September 23rd 2007, Filed In Games
Rating(50%) Comments(32)
If only there really were a world ruled and navigated via point'n'click it would be awesome (also it would be very time consuming trying to leave any room that you were in). Anyway while the boffins work on that one we can play SSSG: Sneaky Land 4: Incidia instead [subbed by Self Defiant, She-Nomad, Robi, Jumisa, Big Bad Dave & anon].
Entry 2920, Friday, September 21st 2007, Filed In Games
Rating(55%) Comments(276)
Time for a Wogger Mini catch up after being off line for a while... 4 new episodes have been released since I was last on-line:
[subbed by ambas, vmklover, Oo, anon, Hewitt, Cyberjar88, Big Bad Dave & vicky].
Entry 2919, Thursday, September 20th 2007, Filed In Games
Rating(49%) Comments(45)
Find the iPhones, and other objects, in the various different scenes in the iPhone Mystery before the countdown runs out and Steve Jobs fires you [subbed by hellervon].
Entry 2915, Friday, September 7th 2007, Filed In Games
Rating(52%) Comments(23)
Escape Magenta Green Room (there seem's to be some confusion over the name, but unless I've gone colour blind it's green) is an escape the room style point'n'click game. The room is Green. You must escape it. You do that by pointing. And clicking. You know sometimes these game descriptions pretty much just write themselves...*takes well deserved break* [subbed by Werewolf].
UPDATE: OK, I don't know what was going on at newgrounds. The game I linked was the green room, the page title said magenta, confusing enough, but then they swapped it back to the magenta room game to match the title. Anyways, I've updated the link now so it goes to the right place.
Entry 2914, Thursday, September 6th 2007, Filed In Games
Rating(59%) Comments(257)
Gymnasium Escape is a Japanese point'n'click game that looks great, but unfortunately has quite a large language barrier that makes playing it a little tricky. All I've managed to work out so far is how to turn on the power in the storeroom, and I was quite impressed with that. Perhaps between us we can work out what is going on here... [subbed by f00].
Entry 2913, Thursday, September 6th 2007, Filed In Games
Rating(14%) Comments(103)
Find The Face is a game with a simple, but different, concept, where you find the cartoon type face in a group of live action videos. Very simple to play, at least for eight of the faces, but I still can't find the ninth face yet [subbed by f00].
Entry 2912, Thursday, September 6th 2007, Filed In Games
Rating(42%) Comments(20)
In Heist you play a thief intent on stealing the biggest diamond in the world. Collect the objects and avoid the security systems to reach your goal and try not to succumb to crippling RSI as you use the ASWD keys (and [Q] for actions) to move around the isometric layout [subbed by kennymfk].
Entry 2911, Thursday, September 6th 2007, Filed In Games
Rating(61%) Comments(52)
New games blog "Shut.In" (featuring new escape the room games every day) has started it's own series of exclusive point'n'click games called "Locked In" (in which, unsurprisingly, you have to... wait for it... wait for it... escape the room... ahhhh...). I'm assuming this first episode was built by the same people who did the puzzled series as it's very similar to, but not entirely the same as, Puzzled 4 [subbed by Mystery].
Entry 2910, Wednesday, September 5th 2007, Filed In Games
Rating(46%) Comments(71)
If you like grow style games where you have to click on the right things, in the right order, to "win" (or click on the wrong things, in the wrong order, to see the hilarious consequences) then Grow Monster Game might appeal to you. Personally though I found the whole thing a bit slow and disappointing. The idea with this one is to click the 8 different elements, in the correct order, to grow your monster and defeat the various foes that you face. Note: This is not part of the "official" grow series, and also I could only get the thing to play in Internet Explorer [subbed by K. Engels & Videocrazy].
Entry 2909, Wednesday, September 5th 2007, Filed In Games
Rating(28%) Comments(35)
Voice: another day, another totally totally incomprehensible Japanese point'n'click game in which I assume I'm aiming to escape the room... One day, I swear to you, these things are going to teach me Japanese. Although, that would have to be after the day that I get round to installing the right character sets/fonts so that the text displays properly... [subbed by Mantari & handyrman].
Entry 2908, Tuesday, September 4th 2007, Filed In Games
Rating(48%) Comments(85)
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This information enables us to identify the rooms that will best accommodate your party and to prepare for your arrival.
See room terms and details for information about rollaway and/or extra person charges.
Please note that at most Starwood hotels, guests 17 and under are considered children. All other guests are considered adults. You will be told of any hotel-specific differences in this policy on the following page.
Sheraton San Diego Hotel & Marina has relaxing and comfortable room accommodations and most have incredible views of either the Bay or Marina. Our 1,053 guestrooms and suites are split between two towers - 705 in the Marina Tower and 348 in the Bay Tower. All feature the Sheraton Sweet SleeperSM Bed. In addition, the Executive Club Level rooms offer complimentary continental breakfast and hors d'oeuvres.
Our San Diego hotel also offers a variety of fine restaurants, three swimming pools, tennis courts, a San Diego Resort spa and jogging trails. Stay connected with the Link@Sheraton experienced with Microsoft. Enjoy complimentary shuttle transportation, which runs every half-hour between 4:45am and midnight, between the Marina and Bay Towers as well as the San Diego International Airport.


text:
Contact Us:
Contact Us
Vaccine & Immunizations Hotline, Webmaster, Address, Phone
Vaccines & immunizations questions
Most people's questions can be answered by their state health department's immunization program.
Please note that CDC-INFO is not able to evaluate specific cases and provide individualized medical advice. Only your healthcare provider can do this properly through a careful review of medical records, lab tests, and physical examination.
The CDC-INFO contact center can answer your vaccines and immunization questions. Please submit questions and/or comments about the topic of Vaccines & Immunizations using the CDC-INFO form at this link:
Webmaster addresses your suggestions and fixes bad links
The web team responsible for the Vaccines & Immunizations website welcomes your suggestions and appreciates your time and efforts to report problems with this site. If you have a comment about a specific web page, please include the URL.
Call or write us (TTY, physical address & email address, etc.)
Phone numbers:
For vaccine & immunization information:
1-800-232-4636 (1-800-CDC-INFO)For information on international travel:
1-877-394-8747Recorded information and fax documents pertaining to international travel including geographic recommendations, health precautions and reported outbreaks. Also see
Mailing address:
NCIRD Public Inquiries
Mailstop A-27
1600 Clifton Road, NE
Atlanta, GA 30333
Remember: Don't send medical records! And, we cannot answer medical questions or provide consultation. These questions are best answered by a doctor who is most familiar with the patient's condition.
TTY users website and hotline:
The CDC Information Hotline TTY Service:
Hours: Monday - Friday, 10:00 to 10:00 p.m. EST.
Call: TTY hotline (888) 232-6348
Topics and services include:
- vaccine safety
- immunization recommendations
- U.S. immunization policy
- vaccine-preventable diseases
- referrals to useful websites and other resources
- offers of free publications about vaccines
Languages available:
- English
- Spanish
Media Contact Info
The media representative responsible for the Vaccines & Immunizations website welcomes your inquires to topics covered on this site. Contact the media representative via the link below.
Vaccines & Immunizations media contact form
This symbol means you are leaving the CDC.gov Web site. For more information, please see CDC's Exit Notification and Disclaimer policy.
File Formats: All viewers, players, and plug-ins used on this site can be downloaded from the file formats page. (For example: Adobe Acrobat Reader for pdf files, Windows Media Player for audio and video files, PowerPoint Viewer for presentation slides, etc.)
Content last reviewed on December 4, 2012
Content Source: National Center for Immunization and Respiratory Diseases


text: A best bet is the adidas Men's Zeitfrei Fitfoam Slide Sandals in Black/Metallic Silver/Blue (pictured) for $28 plus $5 for shipping. (Use the drop-down menu to select this style.) That's the lowest total price we could find now by $2. They're available in sizes from 8 to 11 8 and 9 only.


text:
Package: music-bin (1.0.6-1) [universe]
Links for music-bin
Ubuntu Resources:
Download Source Package music:
Please consider filing a bug or asking a question via Launchpad before contacting the maintainer directly.
Original Maintainer (usually from Debian):
- Mikael Djurfeldt
It should generally not be necessary for users to contact the original maintainer.
External Resources:
- Homepage [software.incf.org]
Similar packages:
Multi-Simulation Coordinator for MPI -- Utilities
MUSIC allows spike events and continuous time series to be communicated between parallel applications within the same MPI job in a cluster computer. Typical usage cases are connecting models developed for different simulators and connecting a parallel simulator to a post-processing tool.
This package contains the MUSIC launch utility.
Other Packages Related to music-bin
- dep: freeglut3
- OpenGL Utility Toolkit
- dep: libc6 (>= 2.4)
- Embedded GNU C Library: Shared libraries
also a virtual package provided by libc6-udeb
- dep: libgcc1 (>= 1:4.1.1)
- GCC support library
- dep: libgl1-mesa-glx
- A free implementation of the OpenGL API -- GLX runtime
- or libgl1
- virtual package provided by libgl1-mesa-glx, libgl1-mesa-swx11
- dep: libglu1-mesa
- The OpenGL utility library (GLU)
- or libglu1
- virtual package provided by libglu1-mesa
- dep: libmusic1
- Multi-Simulation Coordinator for MPI -- Runtime library
- dep: libopenmpi1.3
- high performance message passing library -- shared library
- dep: libstdc++6 (>= 4.4.0)
- The GNU Standard C++ Library v3
Download music-bin
Architecture | Package Size | Installed Size | Files |
amd64 | 253.7 kB | 852.0 kB | [list of files] |
i386 | 246.9 kB | 776.0 kB | [list of files] |


text:
Hike to Oklahoma's secluded highpoint.
Dip into the 8,900-acre McGee Creek Natural Scenic Area for an easy out-and-back that peeks into Bugaboo Canyon and some of OklahomaÛªs least-traveled territory.
Watch for bison, elk and other migratory species on this easy 3.7-mile lollipop loop through oak forests and grassland in southwest Oklahoma's Wichita Mountain Wildlife Refuge.
One of Oklahoma's best weekend trips, this 21.7-mile loop circles Winding Stair Mountain for an up-close view of the Ouachita National Forest's most scenic stretch.
Tulsa, OK: Winding Stair Trail


text:
Since founding ALL-N-1 Landscape in 1995, the happiness and satisfaction of our clients has been our primary concern. When you work with ALL-N-1 Landscape's design architects from concept to installation, your family will treasure the outdoor surroundings of your home while significantly increasing your property value. In fact, by installing a sprinkler system, your home's value could increase as much as 11.3% (according to Smart Money magazine)!
Best of all, your satisfaction with our workmanship is fully guaranteed.
We invite you to browse this site and get to know our professional, down-to-earth team. Take a look at all that we offer, read about our recent landscape design projects and what our clients say about us, and contact us to discuss your custom landscape or sprinkler system.
Our services include: Landscape Design and Installation, Retaining Walls, Patios - Flagstone or Pavers, Outdoor Kitchens, French Drains and Solutions to Drainage Problems, Sprinkler Systems, Water Features, Ponds, Fountains, and Waterfalls, Fireplaces/Firepits, Raised Vegetable Gardens, Christmas and Holiday Lighting, Pergolas, Gazebos, and Decks, and Rain Gardens, Green Roofs, and Natives.
Loading gallery.
Channel 6 News: ALL-N-1 Landscape goes above and beyond for contest winners.
Article on ALL-N-1 Landscape's Sustainable Division in Kansas City Homes and Gardens magazine's December 2011 Issue
Article on ALL-N-1 Landscape's Sustainable Division in Lawrence Magazine's Summer 2011 Issue
Responding to the gap in professional ecologically sound landscaping services in the greater Kansas City area, ALL-N-1 has redesigned many aspects of our company to reflect cutting edge green technologies available in our region. Look for updates throughout our web-site which explain recent green upgrades in our business practices.


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King Size Comforter Set - Charmeuse Satin 4-Piece in Gold - 450KG2GOLD
Item Code: SCENT-450KG2GOLD
Regular:$189.00Sale:$119.99 (You Save 37%)
Usually ships in 5-7 business days, furniture delivery can typically be expected in 1-3 Weeks from order date. Ships from Woodside, NY.
Product Description
Includes comforter, 2 king shams, and a bed skirt.Our luxurious Charmeuse satin comforter set brings the comfort of lingerie to your bed. They are a dream to sleep on and have the silkiest feel ever created.
450KG2GOLD Features:
- 230 thread count
- 100% woven polyester
- Satin on both sides of comforter
- Washes wrinkle free
- Bed skirt fits a 15" mattress
Comforter: 92"(W) x 102"(H)
Bed Skirt: 60"(W) x 80"(H)
Sham: 37"(W) x 21"(H)


text:
Get more from your Chromebook* with Intel Inside® and the performance for more tabs, apps, Hangouts*, games, video, and time unplugged.
There's something inside that fills us with curiosity, seeks adventure, and makes connections; see how your something drives our something inside.
Video demo: comments by elementary students and others on how learning is faster and deeper by using the Intel classmate PC.
JayCut's online video editing service improves with new Intel® Atom™ processors.
Take a high-speed, visual tour of new smartphones with Intel Inside®, highlighting movie, music, photography, and social media features.
Video: Intel presents Cedar Trail next-gen Atom™ platform at IDF 2011.
Supermicro's Raphael Wong covers the Intel® Atom™ processor C2000 product family-based server, delivering a top-to-bottom server and storage solution.
Ad: Trailer for Empire: Total War, a turn-based strategy and real-time tactics computer game.
Video: Find out how Intel® processors contribute to extreme gaming performance.
Video: watch the HAWX* Gameplay trailer on Intel for better experience.


text:
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Coverage: NBATV
10:30 PM ET, November 30, 2009
ORACLE Arena, Oakland, CA
Top Performers
Indiana: D. Granger 22 Pts, 7 Reb, 2 Ast, 3 Stl, 1 Blk
Golden State: M. Ellis 45 Pts, 5 Reb, 1 Ast, 5 Stl
OAKLAND, CA - NOVEMBER 30: Dahntay Jones #1 of the Indiana Pacers drives to the hoop against Monta Ellis #8 of the Golden State Warriors on November 30, 2009 at Oracle Arena in Oakland, California. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, user is consenting to the terms and conditions of Getty Images License Agreement. Mandatory Copyright Notice: Copyright 2009 NBAE (Photo by Rocky Widner/NBAE via Getty Images)


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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand (from the Latin ligandum, binding) is a substance (usually a small molecule), that forms a complex with a biomolecule to serve a biological purpose. In protein-ligand binding, ligand usually is a signal triggering molecule, binding to a site on a target protein. In DNA-ligand binding studies, ligand is usually any small molecule or ion,[1] or even a protein [2] that binds to the DNA double helix.
The binding occurs by intermolecular forces, such as ionic bonds, hydrogen bonds and van der Waals forces. The docking (association) is usually reversible (dissociation). Actual irreversible covalent bonding between a ligand and its target molecule is rare in biological systems. In contrast to the meaning in metalorganic and inorganic chemistry, it is irrelevant whether the ligand actually binds at a metal site, as is the case in hemoglobin.
Ligand binding to a receptor (receptor protein) alters its chemical conformation (three-dimensional shape). The conformational state of a receptor protein determines its functional state. Ligands include substrates, inhibitors, activators, and neurotransmitters. The tendency or strength of binding is called affinity. Binding affinity is determined not only by direct interactions, but also by solvent effects that can play a dominant indirect role in driving non-covalent binding in solution.[3]
Radioligands are radioisotope labeled compounds are used in vivo as tracers in PET studies and for in vitro binding studies.
Receptor/ligand binding affinity[edit]
The interaction of most ligands with their binding sites can be characterized in terms of a binding affinity. In general, high-affinity ligand binding results from greater intermolecular force between the ligand and its receptor while low-affinity ligand binding involves less intermolecular force between the ligand and its receptor. In general, high-affinity binding involves a longer residence time for the ligand at its receptor binding site than is the case for low-affinity binding. High-affinity binding of ligands to receptors is often physiologically important when some of the binding energy can be used to cause a conformational change in the receptor, resulting in altered behavior of an associated ion channel or enzyme.
A ligand that can bind to a receptor, alter the function of the receptor, and trigger a physiological response is called an agonist for that receptor. Agonist binding to a receptor can be characterized both in terms of how much physiological response can be triggered and in terms of the concentration of the agonist that is required to produce the physiological response. High-affinity ligand binding implies that a relatively low concentration of a ligand is adequate to maximally occupy a ligand-binding site and trigger a physiological response. The lower the Ki level is, the more likely there will be a chemical reaction between the pending ion and the receptive antigen. Low-affinity binding (high Ki level) implies that a relatively high concentration of a ligand is required before the binding site is maximally occupied and the maximum physiological response to the ligand is achieved. In the example shown to the right, two different ligands bind to the same receptor binding site. Only one of the agonists shown can maximally stimulate the receptor and, thus, can be defined as a full agonist. An agonist that can only partially activate the physiological response is called a partial agonist. In this example, the concentration at which the full agonist (red curve) can half-maximally activate the receptor is about 5 x 10−9 Molar (nM = nanomolar). Ligands that bind to a receptor but fail to activate the physiological response are receptor antagonists.
In the example shown to the left, ligand-binding curves are shown for two ligands with different binding affinities. Ligand binding is often characterized in terms of the concentration of ligand at which half of the receptor binding sites are occupied, known as the IC50 http://en.wikipedia.org/wiki/IC50, which is related to but different from the dissociation constant. The ligand illustrated by the red curve has a higher binding affinity and smaller Kd than the ligand illustrated by the green curve. If these two ligands were present at the same time, more of the higher-affinity ligand would be bound to the available receptor binding sites. This is how carbon monoxide can compete with oxygen in binding to hemoglobin, resulting in carbon monoxide poisoning.
Binding affinity is most commonly determined using a radiolabeled ligand, known as hot ligand. Homologous competitive binding experiments involve binding-site competition between a hot ligand and a cold ligand (untagged ligand).[4] Non labelled methods such as surface plasmon resonance and dual polarisation interferometry can also quantify the affinity from concentration based assays but also from the kinetics of association and dissociation, and, in the later case, the conformational change induced upon binding. Recently, Microscale Thermophoresis (MST), an immobilization-free method[5] was developed. This method allows the determination of the binding affinity without any limitation to the ligand's molecular weight.[6]
For the use of statistical mechanics in a quantitative study of the ligand-receptor binding affinity, see the comprehensive article[7] on the configuration integral.
Drug potency and binding affinity[edit]
Binding affinity data alone does not determine the overall potency of a drug. Potency is a result of the complex interplay of both the binding affinity and the ligand efficacy. Ligand efficacy refers to the ability of the ligand to produce a biological response upon binding to the target receptor and the quantitative magnitude of this response. This response may be as an agonist, antagonist, or inverse agonist, depending on the physiological response produced.[8] There are two main differences between binding and functional experiments: Functional responses are usually highly amplified translations of receptor stimulus. Therefore, while binding signals emanate from complete receptor populations, functional readouts often utilize only a small fraction of the receptor population in the preparation. This can lead to a greatly increased sensitivity to drugs that possess efficacy. No differences should be seen for antagonists. This amplification can be especially important for the detection of agonism, since potency may be more a function of ligand efficacy than affinity. Thus, a highly efficacious agonist may produce detectable responses at 100 to 1,000 times lower concentrations than those that produce measurable amounts of displacement of a tracer in binding studies. The complex interplay between affinity and efficacy can be misleading in structure activity studies for agonists. For example. Figure 5.1 shows the lack of correlation of relative agonist potency for two dopamine receptor subtypes and the binding affinity on those receptor subtypes for a series of dopamine agonists. This data show that, for these molecules, changes in chemical structure lead to changes in relative efficacy not reflected in the affinity measurement. The relevant activity is relative agonist potency. Therefore, the affinity data are misleading. In this case, a functional assay is the correct approach for optimization of these molecules.[8]
Selective and non-selective[edit]
Selective ligands have a tendency to bind to a very limited types of receptors, whereas non-selective ligands bind to several types of receptors. This plays an important role in pharmacology, where drugs that are non-selective tend to have more adverse effects, because they bind to several other receptors in addition to the one generating the desired effect.
Bivalent ligand[edit]
Bivalent ligands consist of two connected molecules as ligands, and are used in scientific research to detect receptor dimers and to investigate their properties. Bivalent ligands are usually large and tend not to be 'drug-like', limiting their applicability in clinical settings.[9][10] See Lipinski's rule of five.
See also[edit]
External links[edit]
- BindingDB, a public database of measured protein-ligand binding affinities.
- BioLiP, a comprehensive database for ligand-protein interactions.
This article includes a list of references, but its sources remain unclear because it has insufficient inline citations. (February 2008) |
This article needs additional citations for verification. (November 2007) |
- ^ Teif V.B. (2005). "Ligand-induced DNA condensation: choosing the model". Biophysical Journal 89 (4): 2574–2587. doi:10.1529/biophysj.105.063909. PMC 1366757. PMID 16085765.
- ^ Teif VB, Rippe K. (2010). "Statistical-mechanical lattice models for protein-DNA binding in chromatin.". Journal of Physics: Condensed Matter 22 (41): 414105. doi:10.1088/0953-8984/22/41/414105. PMID 21386588.
- ^ Baron, Riccardo; Setny, Piotr; Andrew Mccammon, J. (2010). "Water in Cavity-Ligand Recognition". Journal of the American Chemical Society 132 (34): 12091–12097. doi:10.1021/ja1050082. PMC 2933114. PMID 20695475.
- ^ See Homologous competitive binding curves, A complete guide to nonlinear regression, curvefit.com.
- ^ Baaske P, Wienken CJ, Reineck P, Duhr S, Braun D (Feb 2010). "Optical Thermophoresis quantifies Buffer dependence of Aptamer Binding". Angew. Chem. Int. Ed. 49 (12): 1–5. doi:10.1002/anie.200903998. PMID 20186894. Lay summary – Phsyorg.com.
- ^ Wienken CJ et al. (2010). "Protein-binding assays in biological liquids using microscale thermophoresis". Nature Communications 1 (7): 100. Bibcode:2010NatCo...1E.100W. doi:10.1038/ncomms1093. PMID 20981028.
- ^ Vu-Quoc, L., [1], 2011.
- ^ a b Kenakin, Terrance P. (November 2006). A pharmacology primer: theory, applications, and methods. Academic Press. p. 79. ISBN 978-0-12-370599-0.
- ^ Shonberg, Jeremy; Scammells, Peter J.; Capuano, Ben (June 2011). "Design strategies for bivalent ligands targeting GPCRs". ChemMedChem 6 (6): 963–74. doi:10.1002/cmdc.201100101. PMID 21520422.
- ^ Berque-Bestel, I; Lezoualc'h, F; Jockers, R (December 2008). "Bivalent ligands as specific pharmacological tools for G protein-coupled receptor dimers". Curr Drug Discov Technol 5 (4): 312–8. doi:10.2174/157016308786733591. PMID 19075611.


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Fourth Annual First Friday Art Auction
First Friday Scranton's 2013 Art Auction is coming! This year's auction will be held on Friday, April 12, 2013, from 6-9 p.m. at the Scranton Cultural Center.
Proceeds from the art auction will benefit the non-profit, volunteer-driven First Friday Scranton organization and will help support our monthly art walks and local artistic initiatives. Please come and support those who have so generously donated their art and maybe you could be going home with a beautiful work of art from a talented local artist!