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Isolera™ ELSD-1080 Evaporative Light-scattering Detection for Flash Chromatography The Isolera ELSD (evaporative light-scattering detector) is a universal detector designed for use with Isolera flash purification systems when purifying organic compounds that are undetectable UV or visible light. Flash chromatography with detection and fractionation is now possible when purifying carbohydrates, steroids, lipids, terpenes and other UV-transparent compounds.
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When I was younger, every birthday did give me the "Oh no I'm getting old" dread. Lately, I noticed that feeling went away.
In the past few years, I have lived more intensely than ever before. I took risks, and turned my wildest dream into reality. I learnt that I am much more capable than I give myself credit for. We all are.
I loved and lost. It was bittersweet and all sorts of amazing and heartbreaking at the same time. But most importantly, I learnt about unconditional love, and mutual generosity.
I made new friends; good ones too, when I thought I didn't need new friends anymore. I opened myself up, and broadened my horizons. I learnt more about myself, and the person I want to be. In my family, in my career, in friendships, and in relationships.
What a difference a few years make in your 20's, because each year is like one giant epiphany. So if this is what growing up and "getting old" is all about, then I am more than excited. I am excited to learn more, experience more, and add more adventures to my neverending story.

subset: commoncrawl


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Here's your chance to become a virtual member of our Fashion Buying Team! Be the Buyer allows you to vote on style samples that, with your help, could be sewn for and sold by ModCloth.
Browse through the potential designs, click 'Pick It!' to vote on your favorites, and tell us why you picked or passed them in the comments section. Your vote counts!
Calling all vintage enthusiasts! At ModCloth, you'll find distinctive vintage clothes to treasure and darling vintage decor to adore.
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Videoconferencing Programs for Schools
Dickerson Park Zoo and the Discovery Center are collaborating to offer zoo classes to schools via videoconferencing. Each class is presented by a zoo staff member and will include several live animals.
Animal Awareness
Learn about the characteristics of
mammals, birds, and reptiles, as we compare and contrast these animals.
We'll discuss traits as modeled by our live zoo animals. (Pre-K-2)


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I just found I am pregnant with #7. I am 41 yrs old, and based on lmp I am due May 15th. I have four girls and two boys currently. I would love to join, and get to know all of you :) Congratulations to all of you!!
Sorry, I should have typed this into the other intro thread. I am just so excited, I wanted to post right away...I should have read the other posts first!!
Welcome! Glad you are joining us!
Thank you, Porcelina :)


text: content May 24, 2005 Printer Friendly In this issue Life Extension Update Exclusive: High doses of supplemental vitamin B12 needed to correct deficiency Protocol: Homocysteine Featured Products: Vitamin B12 tablets TMG Life Extension Events Life Extension Update Exclusive High doses of supplemental vitamin B12 needed to correct deficiency The May 23 2005 issue of the American Medical Association journal Archives of Internal Medicine (http://archinte.ama-assn.org/) published the findings of Dutch researchers that much higher levels of vitamin B12 are needed to remedy a deficiency of the vitamin than are provided by the Netherlands' recommended dietary allowance of approximately 3 micrograms per day. (In the US, the daily value for vitamin B12 is 6 mcg, however, the Institute of Medicine's dietary reference intake is lower at 2.4 mcg per day.) A common means of correcting vitamin B12 deficiency is intramuscular injection of the vitamin, however, oral vitamin B12 has also been shown to be effective, although an optimal dose has not been determined. Daily oral doses of 2.5, 100, 250, 500 and 1000 micrograms cyanocobalamin were administered for 16 weeks to 120 people aged 70 and older with vitamin B12 deficiency determined by low serum B12 and elevated plasma methylmalonic acid (MMA). Methylmalonic acid is a compound that is produced in the body when vitamin B12 is insufficient. Vitamin B12 is additionally needed to remethylate homocysteine to the amino acid methionine, therefore elevated total homocysteine can also be an indicator of B12 deficiency. The participants' blood samples were analyzed for cobalamin and MMA at 8 and 16 weeks. Plasma MMA was reduced in all participants at 8 weeks and remained stable through the study's conclusion. Greater mean reductions in MMA were observed with increasing doses of vitamin B12, however, the highest dose of 1000 micrograms cyanocobalamin lowered MMA by the same percentage (33%) as 500 micrograms. Analysis of the data determined that the lowest dose resulting in 80 to 90 percent of the maximum reduction in MMA varied from 647 to 1032 micrograms per day. The authors conclude that "the lowest dose of oral cyanocobalamin required to normalize biochemical markers of mild vitamin B12 deficiency in older people with a mild vitamin B12 deficiency is more than 200 times greater than the recommended dietary allowance for vitamin B12 of approximately 3 micrograms per day. Clinical trials are currently assessing the effects of high doses of oral cobalamin on markers of cognitive function and depression . . . However, the present trial demonstrates that much higher doses of cyanocobalamin are required to normalize vitamin B12 deficiency than were previously believed." Protocol Homocysteine Recent studies show that people with dementia of the Alzheimer's type have elevated levels of homocysteine in their blood. At an international scientific conference held in The Netherlands the week of April 27, 1998 , a team of scientists unveiled findings showing a definitive link between elevated homocysteine and Alzheimer's disease. Research reported at Tufts University in 1995 documented the same finding linking elevated homocysteine and Alzheimer's disease and recommended supplementation with folic acid and vitamin B12. It should be noted that dementia can be caused by a deficiency of vitamin B12, folic acid, and other nutrients, so another reason people with dementia of the Alzheimer's type have elevated homocysteine levels could be that they are suffering from a common vitamin deficiency. Numerous studies conducted on the elderly show that deficiencies of folic acid, vitamin B12, and other nutrients are epidemic in elderly people who do not take vitamin supplements. Since both elevated homocysteine and vitamin deficiencies have been linked to dementia, the best approach to preventing and treating dementia (including Alzheimer's dementia) would appear to be testing the blood for elevated homocysteine and taking methylation enhancing nutrients such as folic acid, TMG, and vitamin B12. Measuring blood levels of homocysteine is a new and potentially life-saving test that provides information about vitamin and methylation status, in addition to determining levels of toxic homocysteine. Those with a family history of heart disease, stroke, or Alzheimer's disease are at a particular risk for elevated homocysteine. Elevated homocysteine has also been linked to complications in diabetes, lupus, and other chronic diseases. While many people have assumed that because they are taking vitamin supplements, their homocysteine levels will be in a safe range, The Life Extension Foundation has discovered that this might not always be the case. http://www.lef.org/protocols/prtcl-122.shtml Featured Products Vitamin B12 tablets Cyanocobalamin is a synthetic and inexpensive form of vitamin B12 that is easily converted in the body to its bioactive forms, methylcobalamin, and cobamamide. http://www.lef.org/newshop/items/item00361.html TMG (trimethylglycine) tablets TMG is also called glycine betaine, but the name "trimethylglycine" signifies that it has three methyl groups attached to each molecule of glycine. Betaine was discovered to be beneficial to heart health back in the 1950's. Research showing TMG's ability to promote healthy levels of homocysteine alone or in conjunction with other nutrients, confirms its status as an important nutrient for cardiovascular health. http://www.lef.org/newshop/items/item00359.html Events Check out Life Extension Events for upcoming happenings around the world to keep you informed on the newest findings in health and longevity. Don't miss the National Conference on Prostate Cancer 2005, which will be held June 16-19, 2005 at the Omni Shoreham Hotel, Washington, D.C. This year's theme is "Exploring New Pathways – Sharing the Journey," and will focus many of the lecture discussions on the "new pathways" for diagnosing, staging and treating prostate cancer. Who Should Attend? Prostate Cancer patients and survivors. Spouses, partners and family members (especially sons) Medical professionals who desire to learn more about prostate cancer and to obtain CME credits. http://www.lef.org/event.html Questions? Comments? Send them to firstname.lastname@example.com or call 954 202 7716. For longer life, Dayna DyeEditor, Life Extension firstname.lastname@example.com West Commercial BoulevardFort Lauderdale FL 33309954 766 8433 extension 7716 Sign up for Life Extension Update at http://mycart.lef.org/subscribe.asp Help spread the good news about living longer and healthier. Forward this email to a friend! View previous issues of Life Extension Update in the Newsletter Archive.


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Brochure | December 20, 2007
Brochure: MTS Jet Aeration Systems
Source: Mass Transfer Systems
MTS jet aerators utilize two-phase jet nozzles to supply atmospheric oxygen to chemical and biological treatment processes. Special process benefits include high oxygen transfer efficiency, independent control of oxygen transfer and mixing, superior mixing, capital and energy savings, and reduced off-gas. Ease of maintenance is achieved through the use of conventional rotating equipment and our unique flushout system.


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Sweet Spring Dress (2013-) Feb 19, 2013 17:28:47 GMT -5 Quote Select PostDeselect PostLink to PostMemberGive GiftBack to Top Post by Lucy Skylar on Feb 19, 2013 17:28:47 GMT -5 Beautiful dress. I enjoy the crochet look to it, but it is a knit dress. The pink flower is sewn on and matches the ribbon that goes through the drop waist of the dress. It has a sparkly thread that is sewn throughout, that is more silver in color than gold. I love this dress and it gets a B+ from me, it would get an A, but I find the sparkly thread to cheapen the appearance slightly.
Sweet Spring Dress (2013-) Feb 26, 2013 18:07:15 GMT -5 Quote Select PostDeselect PostLink to PostMemberGive GiftBack to Top Post by lynnlb on Feb 26, 2013 18:07:15 GMT -5 Here are both Spring dresses on #13 (I'll save you from having to hunt around for the one post).As you can see the ribbon is on the inside ankle on the left shoe ... AG has already sent me a replacement (Great customer service). I really think the bow on this dress would have been a nice size for the BB hat, but as I've noticed lately there are people who love to put those big flowers on their little baby's head. I'm with Jami'sdolls, I think leggings would be adorable on a MAG along with the BB dress.
Sweet Spring Dress (2013-) Feb 27, 2013 11:28:14 GMT -5 Quote Select PostDeselect PostLink to PostMemberGive GiftBack to Top Post by Clover on Feb 27, 2013 11:28:14 GMT -5 Sweet Spring Dress for Dolls + CharmItem# F3621Price: $30My American Girl® dolls make every occasion sweeter in this charming outfit.It features:A cream-and-gold knit dress with crochet lace pattern on the skirt and pretty flutter sleeves. A pink ribbon is woven into the drop waist, and a pink fabric rosette accents the neckline.Pink espadrille shoes have satin elastic crisscross strapsA translucent pink oval barrette for her hairIncludes a "Smart" round charm for the doll's charm-keeper necklace.I was immediately attracted to this dress due to the lack of dresses for my modern girls, and the nice neutral colors.DressThe dress is made from a knit material, slightly off-white with metallic threads. There is a satiny slip under the dress, though not very opaque. As a result, if the doll is wearing any colored underwear, it will definitely show through. The knit material has a bit of stretch, which is nice. The metallic thread is not overdone, and adds a bit of zip. The dress also has a pink flower attached to the left shoulder, which adds a bit of spring/romance to the dress.Grade: A-ShoesThe shoes are a light pink matching the color of the flower on the dress. The shoes have a bit of platform to them, featuring the canvas-like material as the sole. They also have crisscrosed pink elastic with a bow on the outer side of the ankle. The shoes may be a bit confusing for younger girls, and I found it worked best to put on the elastic first over the foot, then slip the shoe on. I like the overall look of the shoe, but they seem a bit tight to me, as my doll's toes are clearly showing underneath, much like someone whose shoes are getting a bit too small for their growing feet.Grade: B+BarretteThe barrette is a translucent pink meant to match the pink accents of the rest of the outfit. Cute, but just a standard hair accessory.Grade: A-Overall, I like this outfit a lot. I usually do not spring for MyAG oufits for my modern girls and rely on seamstresses, but this one stood out to me as a must have. I think it would have been better priced at $28, but it is still cute.If anyone wants pictures, please PM me.
Sweet Spring Dress (2013-) Mar 10, 2013 16:36:42 GMT -5 Quote Select PostDeselect PostLink to PostMemberGive GiftBack to Top Post by dragonflybg on Mar 10, 2013 16:36:42 GMT -5 I love this outfit, especially the shoes. I love the criss cross ankle straps. They are very similar to Nicki's gala outfit shoe straps, but these seem to be a little stiffer material. Maybe it's just because they are new.The dress is lined and has velcro up the back. The sparkly thread doesn't bother me at all. My pink flower was a little squished when it came out of the box, but it popped back up with no problem. The barrette is all plastic.
Sweet Spring Dress (2013-) Mar 31, 2013 12:20:18 GMT -5 Quote Select PostDeselect PostLink to PostMemberGive GiftBack to Top Post by k8c on Mar 31, 2013 12:20:18 GMT -5 I think it's interesting that while AG often shows this on a blonde doll, we've all put this on our brunette dolls. I love it on MG and Molly. The dress is very sweet, and the lining is excellent! It makes the dress lie so nicely. While I'm not a huge fan of the sparkle and the flower, my target-aged daughter loves them. And, in all honesty, they don't bother me nearly as much as I thought they would. I haven't snipped the flower off yet, and that's saying a lot. I wish the dress were a bit longer. And, I think the shoes are the wrong season for this dress. If it's cool enough to wear this sweater dress, then it's cool enough for thin tights and corresponding footwear.We had a same-shoe problem, too! I'll be calling customer service to see if they'll send us a new pair. (And, um...based on the other photos we also had a user malfunction in how the straps ought to be.)


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Search Result
Search Tags: the perfect truffle
Md. chocolatier making voting sweet with truffles
Forget long lines at the polls, hanging chads, and red states and blue states. There is a sweet alternative to this year's election process _ chocolate truffles.
Friday - 09/28/2012, 06:35pm EDT
Tags: The Perfect Truffle, chocolatier


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Life is good®: Men's Go Places Short Sleeve Crusher Tee
Out of Stock
The classic Crusher T from Life is good® is made to fade, with a vintage, weathered look. Offering ultimate durability, signature softness, and an uplifting front graphic, this shirt is sure to be a favorite.
- Relaxed fit
- Piece dyed
- Garment washed for softness
- Herringbone twill taping from shoulder to shoulder
- Double needle stitching
Fabric: | 100% Cotton |


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BadgerCare Plus for Families
BadgerCare Plus Core Plan
Family Planning Only Services
Caretaker Supplement
Fair Hearing Request
Fair Hearing Withdrawal
Find a Provider
Eligibility Management (Income Maintenance) Home >> Customer Help >> Medicaid Help
To see if you may be able to enroll or to apply, go to access.wi.gov.
Application —
Authorization of Representative — F-10126 (English, Hmong, Spanish) (PDF, 453KB)
Change Report — F-10137 (English, Hmong, Spanish) (PDF, 544KB) — Report changes to the local agency or you can report changes online at access.wi.gov.
Disability Application —
Fair Hearing Request —
Fair Hearing Voluntary Withdrawal —
Self-Employment Income Report (SEIRF) form — F-00107, (English, Hmong, Spanish) (PDF KB) — Use this form to report self-employment income.
Statement of Identity —
ForwardHealth Enrollment and Benefits handbook, P-00079, (English, Spanish) (PDF, 667KB) A handbook will be mailed to each family who applies for a ForwardHealth Plan. Translations will be available in the near future.
Guide to Applying for Wisconsin's Health and Nutrition Programs — P-16091 (English, Hmong, Spanish) (PDF, 181KB)
ACCESS/Marketplace Takeaway Card — P-00555 (PDF, 540KB)
Healthy Start, Grow Smart: Baby's first year — one month at a time
Additional Information about Medicaid can be found at dhs.wisconsin.gov/medicaid
Agency Directory - To find the telephone number and address of your local agency.
dhs.wisconsin.gov/aging/EBS/counties.htm or call 1-800-362-3002 to contact a Disability Benefit Specialist or Benefit Specialist at your local Aging and Disability Resource Center (ADRC) or County Aging Office.
Find a provider — If you need to find a Medicaid provider in your area.
Income Limits - To find current income limits.
Legal Services — To find the name and telephone number of who in your area can provide you with legal help. You may also go to:
Legal Action of Wisconsin, Inc. web site at http://www.legalaction.org/, *(exit DHS) or
The Wisconsin Judicare, Inc. web site at www.judicare.org/ *(exit DHS).
Disability Rights of Wisconsin — Disability Rights Wisconsin is a private non profit organization which helps people across Wisconsin gain access to services and opportunity through its advocacy and legal expertise.*(exit DHS)
Last Revised: January 17, 2014


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Computer programmer , Programmer
Basic Interests:
Relationship Status:
Favorite Type of Music:
The 80's, The 90's, Rock, Alternative
Favorite Activities:
Reading, TV watching, Spending time with family/kids, Computer activities, Going to movies, Walking, Listening to music, Shopping, Socializing with friends/neighbors, Eating out/dining out, Bicycling, Relaxing, Playing cards, Cooking, Sleeping, Writing, Bowling, Woodworking
My Photos
My Photo Gallery |
Recent Forum Posts
11-22-2010 (4:22 pm)I don't know if the other mobile apps allow this, but it would be great to log in to our .977 Music account and getting points when we listen on our mobile phones. I'd rather listen to .977 Music rather than my local radio stations since I'm enjoying the music I want to hear rather than what the radio stations think we should listen to.
09-16-2010 (11:14 am)
I'll keep checking back every day using FF, but in the meantime I'll use IETab within FF so I'm still getting my music and points. Hopefully this block within FF will stop soon.


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Click Here to Watch the Whole Video in HD at Club Jeremy Hall
Home of gay porn superstar Jeremy Hall. Club Jeremy Hall features exclusive streaming videos of the hottest jocks online!
I feel most proud of my work when I actually jerk off to my own videos. Which was the case with this video. It was pretty tough to edit because I kept getting hard and wanting to wack off! Zakk has such a nice ass and it felt so good to fuck. I can't wait to have that ass back again!
Pixels: 320X240 | Bitrate: 350K
Pixels: 640X480 | Bitrate: 700K


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Rudder steers personal finance to your in-box
One product that slipped under the radar in the past week is Rudder, an e-mail-based personal finance manager that launched at DemoFall and is a replacement for the now-defunct Spendview (coverage). Unlike a destination site like Mint.com, the idea of Rudder is not to have you continually visit a site to track financial activity. Instead, the idea is to have it delivered to your e-mail in-box.
I met with its creators last week to talk about what would make someone want to get all of this piped into a place where they might already be getting information overload. Rudder founder and CEO Nikhil Roy told me it's more of a utility for trying to cut through all the numbers and get to what's most important--like how much money you can actually use once bills have been paid.
Rudder's name for this magic number is "what's left" and it figures out what you've got for discretionary spending based on when you're getting your next paycheck and what's in your various savings and checking accounts, compared to credit card payments and other bills that need paying off. The entire process is shown to users, something Roy hopes will educate as much as it does take the work out of doing the math yourself.
In addition to this core overview of your finances, you can also set-up reminders when it's time to pay bills. The system will automatically figure out what bills you're paying after keeping an eye on your bank account and credit cards for a few months. You can also add them in manually.… Read more


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Former Nagios Conference Calls out for Speakers
The 4th Open Source Monitoring Conference 2009 on Nagios has released its Call for Papers.
The two day event formerly known as the Nagios Conference has since become an annual meeting for users and developers of open source monitoring solutions. Despite the new name, "the conference will continue to focus on Nagios and its related tools," said Julian Hein, Managing Director of conference organiser Netways.
28 to 29 October in Nuremberg, Germany, open source professionals will meet to discover and share information on the latest developments and best practices around Nagios. "As with each year, the OSMC will offer practical presentations and hands-on workshops, all in a relaxed atmosphere of open discussion and casual networking," added Julian.
A few high flyers from the Nagios community are already confirmed speakers, including Wolfgang Barth, author of the first Nagios handbook, Kristian Köhntopp, architecture and scaling master at booking.com and Michael Lübben, Nagios-portal.org founder and developer of NagVis and NagTrap plugins.
Open to both English and German presentations, the OSMC 2009 Call for Papers, including previous programs can be found at the company's web site.
One month ago the open source project Nagios has been forked into the Icinga project. The Netways firm ascertains that the conference's name change has been planned long before and got nothing to do with the fork. According to the project roadmap, version 0.8.1 will be available next week.
Issue 161/2014
Buy this issue as a PDF
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Tag Cloud
New TLS Attack Takes the S out of HTTPS
Vulnerability affects many Linux web servers
Munich Adopts Kolab
The Bavarian capital shuns Microsoft, Google, and other alternatives to implement an open source groupware solution.
Canonical Announces Ubuntu Smartphones
Phone vendor partnerships bring Mark Shuttleworth's dream of Ubuntu on a phone a step closer to reality.
Piviti Seeks Funding
Donors will get to vote on new features for the free video editor.
Debian Tech Committee Votes for systemd
Debian project puts init out to pasture and says no to Ubuntu's Upstart.
The Mask: Scary New Face of Internet Intrusion
Ultra-sophisticated attack tool might have originated from a state-sponsored intelligence service.
Epoch 1.0 Released
New alternative for init comes with a small footprint and minimal configuration.
Wayland 1.4 Challenges X11
X marks the target for the next-generation windowing system.
Red Hat Adopts CentOS
Super-clone CentOS Linux gets beamed up to the mother ship.
W3C Promotes Media Source Extensions
HTML technology will enable new video editing and playback options.


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Phase I Study of Ipilimumab (Anti-CTLA-4) in Children and Adolescents With Treatment-Resistant Cancer
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This study will examine the safety and efficacy of ipilimumab-an experimental cancer treatment drug used to boost immune response-in children, adolescents, and young adults. Ipilimumab may allow immune cells to react to and destroy abnormal cells in the body, and has been tested in adults for a variety of cancers and has shown responses in some research studies. Because ipilimumab has not been tested in children, adolescents, or young adults, it is considered an experimental drug. The purposes of this research study are to determine the highest safe dose of ipilimumab for children, adolescents, and young adults with solid tumor cancers; examine its effectiveness and possible side effects; and better understand how the body and the immune system process it over time.
Candidates must be between 2 and 21 years of age and must have solid malignant tumors that have been resistant to standard therapy. Volunteers will be screened with a medical history, a clinical examination, and computerized scans such as magnetic resonance imaging (MRI). Participants must have completed their last dose of chemotherapy, radiation, chemotherapy, or antibody or investigational therapy at least four weeks prior to enrollment.
During the study, participants will receive an intravenous dose of ipilimumab once every three weeks. The infusion of ipilimumab will last 90 minutes, and the participant s vital signs will be monitored while the medicine is infusing and several times in the first 24 hours after the first dose (requiring a hospital stay during that time). If the participant is able to tolerate the first dose of ipilimumab, further doses (called cycles ) may be received on an outpatient basis. Blood and urine tests will be given on a regular basis during these cycles. After four cycles, participants whose tumors do not grow and who do not have unacceptable side effects will continue to receive ipilimumab every three months to maintain the current condition, until researchers conclude the study.
Condition | Intervention | Phase |
Sarcoma Wilm's Tumor Lymphoma Neuroblastoma |
Drug: Ipilimumab(anti-CTLA-4 antibody) |
Phase 1 |
Study Type: | Interventional |
Study Design: | Allocation: Non-Randomized Endpoint Classification: Safety Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | A Phase I Study of Ipilimumab (Anti-CTLA-4) in Children, Adolescents, and Young Adults With Treatment Refractory Cancer |
- To determine the tolerance and toxicity profile of ipilimumab in patients less than 21 years of age with refractory tumors at a range of doses up to, but not exceeding the highest dose tolerated in adults.
- Efficacy, immunomodulatory activity.
Estimated Enrollment: | 34 |
Study Start Date: | October 2007 |
Drug: Ipilimumab(anti-CTLA-4 antibody)
Solid tumors represent approximately one fourth of cancer diagnoses in children. Despite intensive regimens, patients with metastatic or recurrent solid tumors have unsatisfactory survival rates. Therefore new therapies are needed to improve outcomes.
Accumulating preclinical and clinical evidence supports the use of biologic approaches to heighten antitumor immunity in order to improve the effectiveness of immune based therapy. Both directly activating immune based therapies such as cytokines and tumor vaccines as well as therapies which disrupt negative counterregulatory signals such as those mediated by CTLA-4:B7 may enhance existent antitumor immune responses.
Antibodies directed against CTLA-4 potently augment immune responses in animal models and anti-CTLA-4 antibodies have demonstrated antitumor effects in a variety of preclinical tumor models.
Phase I and phase II studies using ipilimumab have been performed in adults with a variety of tumor types. Clinical responses have been observed in renal cell carcinoma, melanoma, and prostate cancer. No trials have yet been performed to evaluate ipilimumab in children with malignancy.
To determine the tolerance and toxicity profile of ipilimumab at a range of doses up to, but not exceeding, the highest dose tolerated in adults, in patients less than or equal to 21 years of age with refractory solid tumors.
To assess the pharmacokinetics of ipilimumab administered intravenously in patients less than or equal to 21 years of age with advanced and/or refractory solid tumors.
Patients must be 1-21 years of age at the time of enrollment with solid malignant tumors refractory to standard therapy.
A Phase I dose finding study with 4 planned dose levels.
Three patients will be enrolled at each dose level with an expanded cohort of 12 at the highest or maximum torlerated dose with intent to include 6 patients < 12 years.
Re-induction with 4 infusions of ipilimumab at the assigned dose followed by another maintenance phase is possible for subjects who have progressed during maintenance therapy.
Ages Eligible for Study: | 1 Year to 21 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
AGE: Patients must be greater than or equal to 1 years and less than or equal to 21 years of age.
DIAGNOSIS: Histologically confirmed solid tumors, which may include but are not limited to rhabdomyosarcoma and other soft tissue sarcomas, Ewing s sarcoma family of tumors, osteosarcoma, neuroblastoma, Wilm s tumor, Hodgkin's or non-Hodgkin's lymphoma. Patients with melanoma are eligible. Patients with a previous history of CNS metastases are eligible if the metastases have been treated with surgery and/or radiotherapy, are clinically stable as evidenced by no requirements for corticosteroids, the patient has no evolving neurologic deficits and no progression in residual brain abnormalities without specific therapy over 4 weeks.
MEASURABLE/EVALUABLE DISEASE: Patients must have measurable or evaluable tumors.
- The patient s cancer must have relapsed following or failed to respond to standard therapy and/or the patient s current disease state must be one for which there is no known curative therapy or therapy proven to prolong survival.
- Patients must have completed their last dose of irradiation, chemotherapy, monoclonal antibody, or investigational therapy at least 4 weeks prior to enrollment. For patients who have undergone autologous stem cell transplantation, at least 3 months must have elapsed since transplant.
Patients must have recovered from the toxic effects (to a grade 1 or less) of all prior therapy prior to enrollment, with the exception of the following:
- Hematological toxicity: recovery to levels required below
- Low electrolyte levels (Such individuals should receive appropriate supplementation)
- For patients on anticoagulant therapy or with pre-existing coagulation abnormalities, PT, PTT must return to baseline.
- Liver function tests must resolve to values required below
- Grade 3 hypoalbuminemia
- Alopecia
- Sterility
PERFORMANCE STATUS: Patients greater than 10 years old must have a Karnofsky Score of greater than or equal to 50 and children less than 10 years old must have a Lansky score of greater than 50. Patients who are unable to walk because of paralysis or weakness, but who are up in a wheelchair will be considered ambulatory for the purpose of calculating the performance score.
HEMATOLOGIC FUNCTION: Patients must have adequate bone marrow function, defined as a peripheral absolute granulocyte count of greater than or equal to 1000/microL, hemoglobin greater than or equal to 8 gm/dl, and a platelet count greater than or equal to 50,000/microL (may be corrected with transfusions).
HEPATIC FUNCTION: Aspartate transaminase (AST) and alanine transaminase (ALT), less than or equal to 2.5-fold the upper limit of normal (ULN). Normal total bilirubin.
RENAL FUNCTION: Patients must have normal age-adjusted serum creatinine (see table below) OR a creatinine clearance greater than or equal to 70 mL/min/1.73 m(2).
- For children whose age is less than or equal to 5 years, 0.8 mg/dL
- For children whose age is greater than 5 but less than or equal to 10, 1.0 mg/dL
- For children whose age is greater than 10 but less than or equal to 15, 1.2 mg/dL
- For children whose age is greater than 15, 1.5 mg/dL
-A patient with viral hepatitis (HBV, HCV) or human immunodeficiency virus (HIV) will be excluded from trial to limit confounding variables in the assessment of the potential hepatic toxicity of ipilimumab and uncertain impact of ipilimumab administration on viral replication. Serology will not be required unless infection is clinically suspected. A positive hepatitis B titer does not exclude a patient if immunization has been performed and if there is no history of disease.
INFORMED CONSENT: All patients or their legal guardians (if the patient is less than 18 years old) must sign a document of informed consent (Pediatric Oncology Branch, NCI screening protocol for NIH patients) prior to performing studies to determine patient eligibility. After confirmation of eligibility, all patients or their legal guardians must voluntarily sign the IRB approved protocol specific informed consent to document their understanding of the investigational nature, the risks of this study and their willingness to receive the therapy and undergo the research studies involved including pharmacokinetic studies. The consent must be signed before any protocol related studies are performed (This does not include routine laboratory tests or imaging studies required to establish eligibility). When appropriate, pediatric patients will be included in all discussions in order to obtain verbal assent.
DURABLE POWER OF ATTORNEY (DPA): Patients who are greater than or equal to 18 years of age will be offered the opportunity to assign a DPA so that another person can make decisions about their medical care if they become incapacitated or cognitively impaired.
BIRTH CONTROL: Patients of childbearing or child-fathering potential must be willing to use a medically acceptable form of birth control which includes abstinence, while they are being treated on this study and for 60 days following the last dose. Females of childbearing potential must have a negative pregnancy test within 14 days prior to initiation of study therapy and prior to each additional dose of ipilimumab.
- Primary brain tumors
Clinically significant unrelated systemic illness, such as serious infections or organ dysfunction, which in the judgment of the Principal or Associate Investigators would compromise the patient s ability to tolerate the agents in this trial or are likely to interfere with the study procedures or results. This includes but is not limited to:
- Critically-ill or medically unstable patients
- Patients with active infection or other significant systemic illness
- Patients with active diarrhea
- Patients with active eye inflammation, uveitis
- Presence of a symptomatic pleural effusion
- Patients with symptoms of congestive heart failure or uncontrolled cardiac rhythm disturbance
- History of malignant hyperthermia
- Concurrent or history of autoimmune disease excluding stable asthma
- Positive direct Coombs testing or history of hemolytic anemia
- Patients with a history of ongoing or intermittent bowel obstruction
- Concurrent radiation
- Patients with a history of allogeneic bone marrow transplantation.
- Untreated CNS metastases will render the patient ineligible however patients with a previous history of CNS metastases are eligible if: the metastases have been treated with surgery and/or radiotherapy, are clinically stable as evidenced by no requirements for corticosteroids, the patient has no evolving neurologic deficits and no progression in residual brain abnormalities without specific therapy are eligible one week post radiation or radiosurgery. Patients with asymptomatic subcentemeric CNS lesions will be eligible for trial if no immediate radiation or surgery.
- Patients with a history of previous therapy with ipilimumab will be excluded from study participation.
Treatment with any of the following immunomodulatory agents within 14 days prior to study entry:
--Systemic corticosteroid therapy
Retinoic acid
- Fenretinide
- Interferons or interleukins
- Cytokine-fusion proteins
- Growth hormone
- Treatment with myeloid growth factors (GM-CSF or G-CSF) within 72 hours prior to study entry.
- Patients with autoimmune disease, including autoimmune hemolytic anemia, ulcerative and hemorrhagic colitis, endocrine disorders (e.g., thyroiditis, hyperthyroidism, hypothyroidism, autoimmune hypophysitis/hypopituitarism, and adrenal insufficiency),
sarcoid granuloma, myasthenia gravis, polymyositis, and Guillain-Barre syndrome.
- Pregnant or breastfeeding females are excluded because ipilimumab may be harmful to the developing fetus or nursing child.
- Concurrent administration of any other investigational agent.
Contact: Crystal L Mackall, M.D. | (301) 402-5940 | email@example.com | |
Contact: Melinda S Merchant, M.D. | (301) 443-7955 | firstname.lastname@example.com |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 | |
Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office (888) NCI-1937 | |
United States, Massachusetts | |
Dana Farber Cancer Institute | Recruiting |
Boston, Massachusetts, United States, 02115 | |
United States, New York | |
Memorial Sloan Kettering Cancer Center | Recruiting |
New York, New York, United States, 10021 |
Principal Investigator: | Melinda S Merchant, M.D. | National Cancer Institute (NCI) |
Additional Information:
ClinicalTrials.gov Identifier: | NCT01445379 History of Changes |
Obsolete Identifiers: | NCT00556881 |
Other Study ID Numbers: | 080007, 08-C-0007 |
Study First Received: | September 30, 2011 |
Last Updated: | January 18, 2014 |
Health Authority: | United States: Federal Government |
Keywords provided by National Institutes of Health Clinical Center (CC):
Solid Tumor Monoclonal Antibody Pediatrics Pharmacokinetics |
Immunotherapy Sarcoma Lymphoma Neuroblastoma |
Additional relevant MeSH terms:
Lymphoma Wilms Tumor Neuroblastoma Sarcoma Neoplasms by Histologic Type Neoplasms Lymphoproliferative Disorders Lymphatic Diseases Immunoproliferative Disorders Immune System Diseases Neoplasms, Complex and Mixed Kidney Neoplasms Urologic Neoplasms Urogenital Neoplasms Neoplasms by Site |
Neoplastic Syndromes, Hereditary Kidney Diseases Urologic Diseases Genetic Diseases, Inborn Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumors, Primitive Neoplasms, Neuroepithelial Neuroectodermal Tumors Neoplasms, Germ Cell and Embryonal Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue Neoplasms, Connective and Soft Tissue Antibodies Cytotoxic T-lymphocyte antigen 4 Immunologic Factors |
ClinicalTrials.gov processed this record on March 11, 2014


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State of the Position: Linebackers
State of the Position is a new weekly Foxboro Blog feature that will examine the post-draft status of each position and take a look at what needs still need to be filled before the season opens up.
Today we will examine the linebackers.
It seems like the same old story: Who will put pressure on the passer?
Ever since the Super Bowl loss to the Giants, the Patriots' linebackers have taken a significant step back in both talent and production.
Bill Belichick broke his trend of passing on linebackers in round one by selecting Jerod Mayo in 2008.
All he's done since then is earn Rookie of the Year honors and All-Pro status last season.
In 2010 he took two Florida linebackers: Jermaine Cunningham and Brandon Spikes. Both players contributed early on, with Spikes stepping in as an effective run stuffer.
Cunningham put pressure on the quarterback, but clearly has to finish better.
However, both players look like they will fill two starting spots in this linebacker corps for years to come.
Beyond Cunningham and Spikes, a 2010 undrafted free agent proved to be better than his draft status would indicate.
Former Montana State defensive end Dane Fletcher showed playmaking ability as a subpackage linebacker, recording 23 tackles, two sacks, a forced fumble and an interception in limited duty.
With Mayo, Spikes, Fletcher and Gary Guyton filling out the depth chart, the inside linebacker spot is a strong point for this young defense.
All four players are still maturing and can contribute in specific roles as Guyton and Fletcher are better suited for passing downs while Spikes is a two-down beast.
However, the real problem still remains at outside linebacker.
Last year, Tully Banta-Cain entered the season as one starter after posting double-digit sacks in 2009. Apparently someone forgot to remind him that over half of those came against the Buffalo Bills' pathetic offensive line.
By season's end, Banta-Cain was no longer starting as journeyman Rob Ninkovich earned more playing time.
Like Fletcher, Ninkovich is a hard worker who made some big plays, highlighted by his two-interception effort against the Dolphins.
While he may not have great upside, I think Ninkovich definitely has the ability to be an effective player in a rotation.
Beyond Ninkovich and Cunningham, the other options are underwhelming at best.
Eric Moore made an impact in limited duty after being signed as a free agent, but there are questions about his ability to hold up over a 16-game season.
Sixth-round pick Markell Carter has some physical ability, but he will quickly realize the jump in competition from Arkansas State and the NFL is drastic.
Overall, without a proven pass rusher, this group is below average.
State of the Position Grade: Inside Linebacker: B+ Outside Linebacker: C-


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Looking for something else?
NH Frankfurt AirportMörfelder Str. 113, 65451 Kelsterbach (Show map)
Very good
Score from 1235 reviews
friendly staff, very good breakfast with comfortable room.
Modern and very clean Hotel Good hotel for short stay
Everything was very good.
Like all stuff who helped us for Feb 24-26 stay. All with sweet smiles n friendly helpful manner!!
Its very close to the airport and really convenient.
Great location for an Airport Hotel. Clean and quiet.
Restaurant was wonderful. Free shuttle was so nice!
The staff were very nice and friendly and the room was very clean and comfortable.
best choice for 1-2 nights.
Spacious, clean and comfortable room with bath and all the necessities. Was very quiet, despite its proximity to the airport. Very pleasant staff.
This 4-star hotel is just one mile from Frankfurt Airport, and a free shuttle service is available. The NH Frankfurt Airport provides a 24-hour front desk, free Wi-Fi, and free use of the spa and gym. The air-conditioned rooms of the NH Frankfurt Airport feature modern décor and include hardwood floors, a free minibar and a flat-screen TV. A full breakfast buffet and a selection of Spanish and Mediterranean dishes are served in the stylish nhube restaurant, which also includes a work lounge. Drinks and snacks can be enjoyed on the summer terrace. The NH Hotel Frankfurt Airport offers on-site parking for a fee, and great access to Highway A3. It is 15 minutes by car or train from Frankfurt city center, and 20 minutes from the Frankfurt Trade Fair. We speak your language! Hotel Rooms: 156, Hotel Chain: NH Hoteles. Why use Booking.com?Why use Booking.com?Low ratesNo booking fees • Save money! • Best Price Guaranteed 435,522 properties worldwide
Including 117,200 vacation rentals Unbiased reviews26,350,000 reviews from real guests We speak your languageWebsite and customer service in English (US) and 41 other languages Booking is safeWhen you book with us your details are protected by a secure connection. OutdoorsGrounds, Terrace ActivitiesSauna, Fitness Center, Turkish/Steam Bath Food & DrinkRestaurant, Bar, Breakfast in the Room InternetFree! Wi-Fi is available in all areas and is free of charge. Free! Wi-Fi is available in public areas and is free of charge. ParkingPublic parking is available on site (reservation is not needed) and costs EUR 16 per day. ServicesRoom Service, Packed Lunches, Car Rental, Shuttle Service (Free), Airport Shuttle (Free), 24-Hour Front Desk, Baggage Storage, Laundry, Dry Cleaning, Shoeshine, Meeting/Banquet Facilities, Business Center, Fax/Photocopying GeneralNewspapers, Safe, Non-smoking Rooms, Facilities for Disabled Guests, Elevator, Hypoallergenic room available, All Spaces Non-Smoking (Public and Private) Languages spokenEnglish , German Check-in3:00 PM - 12:00 AM Check-out7:00 AM - 12:00 PM Cancellation/
MEININGER Hotel Frankfurt Main / AirportThis 3-star superior hotel is just half a mile from Frankfurt am Main Airport Terminal 2.Most recent booking for this hotel was 18 minutes ago
Score from 4315 reviews
Very good
- 8.1/10
Hilton Garden Inn Frankfurt AirportThe Hilton Garden Inn is in the iconic The Squaire building at Frankfurt Airport, right above the intercity train station.Most recent booking for this hotel was 5 minutes ago
Score from 2335 reviews
- 8.7/10
ibis Hotel Frankfurt AirportThis hotel in Kelsterbach is only 2.5 miles from Frankfurt Airport and 8 miles from the center of Frankfurt. It offers a free airport shuttle and quick public transportation.Most recent booking for this hotel was today at 03:18
Score from 760 reviews
- 7.9/10
Park Inn by Radisson Frankfurt AirportJust half a mile from Frankfurt Airport's Terminal 2, this hotel offers soundproof rooms with flat-screen TVs. It has a modern gym, a steak restaurant and an airport shuttle service.Most recent booking for this hotel was yesterday at 20:55
Score from 254 reviews
- 7.6/10


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Please enter your travel dates.
Standard Room, 2 Queen Beds, Non Smoking
- FREE Breakfast
Breakfast is included in your stay.
- FREE Parking
Parking is included in your stay.
Standard Room, 1 King Bed, Non Smoking
- FREE Breakfast
Breakfast is included in your stay.
- FREE Parking
Parking is included in your stay.
Fort Mill hotel with a seasonal outdoor pool
Situated in the city center, this hotel is close to Carowinds Theme Park, Regent Park Golf Club, and Knights Stadium. Area attractions also include President James K. Polk State Historic Site and Carolina Place Mall.
Hotel Features
Quality Inn at Carowinds provides complimentary wireless Internet access, complimentary high-speed (wired) Internet access, a business center, and a computer station.
Room Amenities
Flat-screen televisions come with cable channels. Guestrooms also feature complimentary wireless Internet access, refrigerators, and microwaves.
Information missing or incorrect? Tell us!Hotel Amenities
- General
A computer station is located on site and high-speed wired and wireless Internet access is complimentary. This hotel offers access to a business center. This Fort Mill hotel also offers a seasonal outdoor pool, complimentary newspapers in the lobby, and a safe deposit box at the front desk. Onsite self parking is complimentary.
Quality Inn at Carowinds is a smoke-free property.
- Air-conditioned public areas
- Total number of rooms - 68
- Number of floors - 2
- Business center
- Business services
- Complimentary newspapers in lobby
- Free Wi-Fi
- Free wired high-speed Internet
- Computer station
- Free self parking
- Safe-deposit box at front desk
- Free outdoor parking
- Free long-term parking
- Free RV, bus, truck parking
- Smoke-free property
- Number of buildings/towers - 1
- Swimming pool - outdoor seasonal
- Internet
Available in all rooms: Free Wi-Fi
Available in some public areas: Free Wi-Fi, Free wired high-speed Internet
- Parking
Free long-term parking, Free outdoor parking, Free self parking, Free RV, bus, truck parking
- Room Amenities
- Air conditioning
- Voice mail
- Phone
- Free local calls
- Refrigerator
- Coffee/tea maker
- Microwave
- Pay movies
- Wake-up calls
- Hair dryer
- Iron/ironing board
- Desk
- Cable TV service
- Flat-panel TV
- Free Wi-Fi
- Connecting / adjoining rooms available
- Cribs/infant beds (complimentary)
- Accessibility
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- In-room accessibility
- Accessibility equipment for the deaf
- Accessible path of travel
- Accessible parking
Policies & Fees
- Check-in
Check-in time starts at 4 PM
- Check-out
Check-out time is 11 AM
- Payment types
Accepted at this hotel: American Express, Carte Blanche, Diners Club, Discover, JCB International, MasterCard, Visa
- Pets
Pets not allowed
- General
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Only service dogs are allowed
24-hour check-in
No rollaway/extra beds available
- Additional Details
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.


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(4 Recipes) Created by AMBERJAM
Recipes in this Collection
I actually got the basics of this recipe when I went to a tops meeting with my mother in law! Get em crispy enough and they are soo tasty! Like eating chips or popcorn but without most of the guilt because they are so jam packed with protein and only have under 200 calories a serving. It feeds four as an appetizer but I'm not gonna lie, I've sat down and had em for lunch and ate an entire batch! They even have a good amont of fiber so enjoy! Submitted by MSKNEENIE Carbs: 17.5g | Fat: 8.8g | Fiber: 6.1g | Protein: 5.3g | Calories: 147.5
A great anytime snack that everyone will love! Submitted by CHRIS2365 Carbs: 11g | Fat: 0.3g | Fiber: 2g | Protein: 0.1g | Calories: 42.4
Very Good 4.6/5
(36 ratings)
Make into bread or muffins. Great for a snack or breakfast. Submitted by JENNLAVOIE Carbs: 20.6g | Fat: 1.8g | Fiber: 0.7g | Protein: 1.8g | Calories: 105.1
Very Good 4.9/5
(19 ratings)
Submitted by PURPLEINDIAN09 Carbs: 19.8g | Fat: 0.7g | Fiber: 7.1g | Protein: 2.7g | Calories: 83.3
Send this recipe collection to a friend - http://recipes.sparkpeople.com/cookbooks.asp?cookbook=223003


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View Image Gallery Kirsty Adams(Full member)
Tel: +44 7714 334364 Email: Web: www.kirstyadams.com
Current WorkKirsty makes hand thrown tableware pieces and larger studio porcelain pieces working to commission, order and for exhibitions. She works only in porcelain.� Technical InformationElectric kiln. Stoneware fired to 1260 - 1280 deg. C. History1988 - 1989 York College of Arts & Technology, Foundation course in Art & Design Press and Publicity2012 Food & Wine Magazine (USA) Exhibition HistoryNov 2012 Handmade in Britain, Chelsea Town Hall |
Profile ImageView Image Gallery Selected ImagesContact DetailsStudio Address: 18 Mackenzie Road, Beckenham, Kent, England, BR3 4RU.View in Google Maps Telephone: +44 7714 334364 Email: Web-site: www.kirstyadams.com Availability: I am happy to arrange work to be viewed by appointment. Last Updated: 2013-01-18 Events featuring this potter
Chelsea Old Town Hall : Handmade in Britain 14: Spring Edition Work styles:
Porcelain |


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A Times Sportswriter Fondly Recalls the Heyday of Payola
I'm springing for $319 tickets to the All-Star Game at Citi Field.
It brings to mind my days as a sportswriter at The New York Times. One day I opened my mail, and there, unsolicited, were Knicks and Rangers season tickets. I also had season tickets for the Jets. I had a pass that let Read More


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Your jewelry should reflect your personal style. Shopping at Shankar Arts in Deadwood means you don't have to settle for mass-produced sameness.
Each piece from Shankar Arts and Collection Georgette reflect fine craftsmanship that comes straight from the gem cutters' wheels.
Through years of travel to Africa, Asia and India, Shankar Arts owners Phil and Georgette continue to bring fine hand-crafted designs from artisans who create one-of-a-kind designs. This is jewelry from cultures where artistic expression and individualism remain highly valued.
Georgette and Phil invite you to shop our online store and see what treasures await you. Our sole intent is to design and collect extraordinary handmade jewelry like no other!


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Jenne, Inc. Helps Integrator Intelligent Enterprise Solutions Compete for
AVON, OH -- (Marketwire) -- 07/12/12 -- Jenne, Inc., a leading value-added distributor of IP... More
AVON, OH -- (Marketwire) -- 07/12/12 -- Jenne, Inc., a leading value-added distributor of IP... More
LAGOS, Nigeria (AP) -- A truck carrying fuel veered off the road into a ditch, caught fire and... More
WASHINGTON (AP) -- Republicans pushed a bill through the House Thursday that allows the... More
WASHINGTON (AP) -- House Speaker John Boehner said Thursday that no decision has been made on... More
TORONTO (AP) -- Canada's Supreme Court has ruled that copyright tariffs should not be levied on... More
FRANKFURT, Germany (AP) -- The CEO of General Motors' loss-making European business abruptly... More
FRANKFURT, Germany (AP) -- Global stock markets declined Thursday on fears growth may slow in... More
FARNBOROUGH, England (AP) -- Boeing beat Airbus in the aircraft order stakes at this year's... More
WASHINGTON (AP) -- Republicans have pushed a bill through the House that would free gold, copper,... More
THE RULING: An Icelandic court ordered the local partner of Visa and MasterCard to resume... More
WASHINGTON (AP) -- Senate leaders have agreed to vote on rival Democratic and Republican plans to... More
SETTLEMENT: New York officials say three Asia-based companies have agreed to pay $571 million to... More
RISK REWARDED: Emerging market bond mutual funds are among the top performers so far this year... More
NEW YORK (AP) -- The economic sentiment is "exceedingly glum" all around the world as the public... More
OMAHA, Neb. (AP) -- Billionaire investor Warren Buffett said Thursday that U.S. economic growth... More
LITTLE KNOWN BUYER: A Qatari investment firm called Mayhoola for Investments will acquire... More
BOSTON (AP) -- Investors continue to pour their money into bonds. And the decline in the stock... More
PHNOM PENH, Cambodia (AP) -- The Obama administration now has a taste of the difficult diplomacy... More
NEW YORK (AP) -- The price of oil has been on a bumpy ride, changing direction almost every day... More
THE ORDER: United is buying 150 Boeing 737s, including 100 new 737 Maxes with a more... More
COLLISION: The French carmaker PSA Peugeot-Citroen says it's slashing 8,000 jobs in France and... More
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NEW YORK (AP) -- The price of oil is falling as the latest batch of data deliver mixed views of... More
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NOUAKCHOTT, Mauritania (AP) -- Seven people were killed in Mauritania on Thursday in the crash of... More


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Slideshow posted in Sports | Sunday, January 15, 2012
4 of 156: These photos were sent in by viewers through our iWitness Reports. If you snapped photos from Sunday's Chevron Houston Marathon, Aramco Half Marathon or EP5K, send them to us at firstname.lastname@example.com or upload them here! ( Photo / iWitness Reports)


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Quick Facts
- NAME: Ian Poulter
- OCCUPATION: Golfer
- BIRTH DATE: January 10, 1976 (Age: 38)
- PLACE OF BIRTH: Stevenage, England, United Kingdom
- Full Name: Ian James Poulter
- AKA: Ian Poulter
- Nickname: Poults
- ZODIAC SIGN: Capricorn
Best Known For
English golfer Ian Poulter is a successful member of both the PGA and European tours.
Think you know about Biography?
Answer questions and see how you rank against other players.
Play NowIan Poulter. (2014). The Biography Channel website. Retrieved 06:37, Mar 11, 2014, from http://www.biography.com/people/ian-poulter-21013649.
Ian Poulter. [Internet]. 2014. The Biography Channel website. Available from: http://www.biography.com/people/ian-poulter-21013649 [Accessed 11 Mar 2014].
"Ian Poulter." 2014. The Biography Channel website. Mar 11 2014, 06:37 http://www.biography.com/people/ian-poulter-21013649.
"Ian Poulter," The Biography Channel website, 2014, http://www.biography.com/people/ian-poulter-21013649 [accessed Mar 11, 2014].
"Ian Poulter," The Biography Channel website, http://www.biography.com/people/ian-poulter-21013649 (accessed Mar 11, 2014).
Ian Poulter [Internet]. The Biography Channel website; 2014 [cited 2014 Mar 11] Available from: http://www.biography.com/people/ian-poulter-21013649.
Ian Poulter, http://www.biography.com/people/ian-poulter-21013649 (last visited Mar 11, 2014).
Ian Poulter. The Biography Channel website. 2014. Available at: http://www.biography.com/people/ian-poulter-21013649. Accessed Mar 11, 2014.
English golfer Ian Poulter was born in Stevenage, England, in 1976. The son of a golfer, Poulter started playing the game at age 4. He turned pro in 1995, and joined the European and PGA tours in 1999. Poulter has won several tournaments over the past several years, and is well known for his feisty, competitive attitude. He has also steered Europe's Ryder Cup team to several big victories.
"I might not swing it the best in the world. I probably wasn't given as much talent as some other people. It doesn't have to be picture perfect. You just have to get the job done."
"If you're just out there making birdies, winning an easy match, that's great. But it's nice to have a good tussle."
"When I hear a few comments, I kind of want to play well to put those people right."
Early Years
British professional golfer Ian James Poulter was born on January 10, 1976, in Stevenage, England. Immersed in the game of golf at an early age, Poulter, whose father, Terry Poulter, was a single-digit handicapper, started playing the sport at the age of 4, after being handed down a miniature 3-wood.
By age 14, Poulter was working a store, selling shirts exclusively to fund his playing. Well-known for his hard work and tenacity, Poulter was in his late teens before he was finally recognized as one of England's top young players.
Poulter turned pro in 1995, and soon after, became known and insulted for his scrappy, sometimes tenacious attitude and play. It seemed then, as it has throughout his career, that the golfer had found a way to thrive on negative comments from antagonists and naysayers.
"When I hear a few comments, I kind of want to play well to put those people right," Poulter has said. "I might not swing it the best in the world. I probably wasn't given as much talent as some other people. It doesn't have to be picture perfect. You just have to get the job done ... If you're just out there making birdies, winning an easy match, that's great. But it's nice to have a good tussle."
Coupled with this feistiness is a temper that has put the golfer in some hot water. In 2006, Poulter was fined for berating a marshal at the Irish Open. In 2010, he became surrounded by controversy after using an anti-Semitic slur in a Twitter post. He later apologized for the tweet.
Pro Success
Four years after turning pro, Poulter made a huge career leap, earning both his PGA and European tour cards. Over the next several years, he would string together a series of victories, including the Italian Open in 2000 and 2002, the Moroccan Open in 2001, the 2003 Celtic Manor Resort Wales Open and the 2003 Nordic Open.
In 2004, Poulter went down to the wire against Spain's Sergio Garcia before prevailing in sudden death at the Volvo Masters. That same year, he played in his first Ryder Cup, a European route at the Oakland Hills Country Club in Bloomfied Township, Michigan, and won one of two matches. Poulter has in fact earned a reputation as a steely composed competitor at the Ryder Cup, one of golf's most prestigious tournaments. In 2008, he won four of five points for his European team, which fell to the U.S. team in overall play.
Four years later, Poulter was again front-and-center at the Ryder Cup, steering the team to an improbable come-from-behind victory. On the second to last day of the match, Poulter, who was teamed with the world's No.
profile name: Ian Poulter profile occupation:
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Famous Capricorns 524 people in this group
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March 15 2014 BOOKLIST
January 2014
Titles similar to Cold Wind
When Joe Pickett's mother-in-law is accused of murdering her latest husband, there's a part of him that can't believe his good luck: the social-climbing harpy has had it in for him ever since he married his beloved Marybeth. Unfortunately, it's hard for him to believe she's guilty. Could a petite woman in her midsixties really hoist a body to the top of a wind turbine and chain it to the spinning blade? What's her motive, anyway? Reluctantly, the dogged Wyoming game warden begins his own investigation, one that seems to ruffle the feathers of just about everybody involved. The eleventh installment in Box's superlative series returns Pickett to his old stomping grounds, Twelve Sleep County, and spins a complicated mystery that entangles familiar series characters in new and surprising ways. Despite Joe's guess that "things are going to get real Western," they end with a courtroom surprise ("like fuckin' Perry Mason!" as one old-timer observes). But a closing scene promises plenty of action in the next book, featuring fan favorite Nate Romanowski. Box's many fans won't be disappointed.
HIGH-DEMAND BACKSTORY: The 75,000-copy first printing may or may not cover all the devoted fans of Box's long-running series.


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Hay For Sale
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Stone Faison 4501 Efland Cedar Grove Rd. ORANGE COUNTY Efland, NC US 9193607196 Comments: High quality fescue and orchard mix 5$ good quality fescue and orchard mix 4$ Best way to contact me is by phone 9193607196. Call for appointment. If you want to come get a sample bale to see if you like it we can set up a time.
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Four University of Utah students who police say were caught smoking pot in an igloo are facing possible discipline from campus officials.
Workers at a Mississippi funeral home say they found a man alive and kicking when they opened a body bag.
Atlanta police are searching for a woman dressed in a Waffle House uniform who walked into a restaurant pretending to be an area manager — and left with about $100 in cash from the register.
A convenience store clerk's mistake has paid off in a big way for a western New York man.
Police say they were called in to restore order in downtown Stockholm after Sweden's public employment service accidentally sent an email invitation for a recruitment event to 61,000 jobseekers instead of 1,000.
The next time you start shaking your finger and shouting "Shame on you!" because your dog chewed up your favorite fuzzy slippers, just remember that no matter how guilty your dog looks, it doesn't know what your rant is about.
A Northern California couple out walking their dog on their Gold Country property stumbled across a modern-day bonanza: $10 million in rare, mint-condition gold coins buried in the shadow of an old tree.
The owner of a 1965 Volkswagen Beetle discovered in Detroit nearly 40 years after it was stolen says he never stopped thinking about that car.
First Joshua Linson knocked out the lights. Then he knocked out Winston-Salem State, ending a basketball game that took three days to complete.
After 19 rounds in a Missouri county's annual spelling bee over the weekend, only two of the 25 contestants who started the competition remained.
A Cincinnati traffic reporter has gained national attention for his dramatic on-air parody of a Disney movie song.
Customers of some medical marijuana dispensaries are discovering this week that they don't have to go far if they have a case of the munchies.
The results of an auction just might put a fork in the mini-flap over New York Mayor Bill de Blasio's decision to use cutlery to eat pizza at a Staten Island restaurant.
Connecticut's last dry town is considering whether to give up on Prohibition.
Looks like the U.S. gets Justin Bieber. At least, one Chicago-area company thinks so.


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Administration Building Room 105 P.O. Box 443151 Moscow, ID 83844-3151 Phone: (208) 885-6365 email@example.com
Convocation is the official welcome and start to the academic year. Some elements of convocation resemble commencement (graduation) which marks the culmination of education at the University of Idaho. In academia, the word "convocation" refers to a ceremonial assembly of the members of a college or university.


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History and tradition don't always lead to innovation, but in the case of El Pomar Foundation these three words are intertwined.
History means we've been around a long time--since 1937 when entrepreneur Spencer Penrose and his wife Julie established a legacy to serve as a valuable resource for the people of Colorado.
Click here to learn more about the history of El Pomar Foundation.
Tradition means we do some things year in and year out. Grantmaking is one example. El Pomar Foundation makes grants to nonprofit organizations in the state of Colorado--and has been doing so since the Foundation was established. Some grantees have been funded on a regular basis since the days when the Penroses made grant decisions themselves.
Click here to learn more about grants.
Innovation means the trustees of El Pomar are constantly looking for new ways to achieve the mission set forth by the Penroses-- to enhance, encourage and promote the current and future well-being of the people of Colorado. El Pomar's extensive programs are an example of innovation in action. The program details are all different, but together they support the same objectives of developing leaders and strengthening communities.
Click here for information about El Pomar's programs.
Valley Courier - Keith Cerny
Valley Courier
The Gazette- Joe Paisley
The Gazette – Bill Vogrin
Spacefoundation.org – Carol Hively
The Gazette – Jakob Rodgers
The Colorado Springs Business Journal
The Colorado Springs Business Journal – Rebecca Tonn
Valley Courier – Nancy Butler and Angie Krall


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View all our puppies at www.bramepuppies.com! Jersey is a smooth-haired tri-colored cutie! He is searching for the perfect new home! Jersey's mom is 1/2 Beagle and 1/2 Australian Shepherd, while dad is a tri-colored Beagle. He needs plenty of room to run and explore and of course, lots of love and attention!! He now lives on a cattle ranch in Southeastern Oklahoma. Our puppies are part of the family and they know it! We prefer our puppies to be picked up in Oklahoma but we can ship them to many cities in the US (additional $250). Your puppy would travel on a passenger plane in a pet carrier/taxi and depart Dallas, TX and arrive in its new city the same day. You would need to pick your puppy up at the airport. The puppies travel in a climate-controlled, pressurized area of the plane and have food and water in their crate. We do require a non-refundable deposit to hold our puppies, then before shipment the balance on the puppy and shipping fee is due. We
Cara - German Shepherd Mix Female
Maddie - Greater Swiss Mtn Dog Mix Female
Champ - German Shepherd Mix Male


text: What's Hot Spring Fashion Preview Watch Snob SXSW GALLERIES Kelly Rutherford Judy Licht Judy Licht Matthew Mcconaughey Matthew Mcconaughey James Patrick James Patrick James Patrick Herman James Patrick Herman Coming Next OR 0 20 Back to Top ▲ Kelly Rutherford Kelly Rutherford AskMen Editors With a successful acting career that has seen her appear in shows like Melrose Place and Gossip Girl, it's slightly ironic that Kelly Rutherford's private life has turned into a paparazzi-funding, tabloid-selling mess. That's thanks to a very ugly, very public divorce from her husband, German entrepreneur Daniel Giersch. Continue reading Kelly Rutherford's profile. Next Page More Like This Promoted Best of the Web Special Features


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Cupcake wrappers & toppers, banners, favor tags, thank you cards, cake toppers, and more!
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Pink Bird Cake Topper
This listing is for 1 Pink Bird Cake Topper. Each topper is hand assembled with 4 layers of cardstock and come preassembled on a 4 inch lollipop stick. All you need to do is put it into your cake for an easy decoration!
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November 1st, 2012
Caption Contest For A Calendar!
You know what you guys haven't done in awhile? Made me laugh. This is a completely one-sided relationship that we have where we make you laugh and you never return the favor. Amuse me people. It's caption contest time!!!! Winner gets to lick that scooter seat and you know what, how about a copy of our new PeopleOfWalmart 365 day calendar. That sounds good, I'll have that.
Caption Contest For A Calendar!, -
I still couldn't bring myself to make FUN of someone's size. Too many of my beloved friends are big folks.
But what I DO know is, they wouldn't leave the house looking this ridiculous. In fact, they dress VERY well, so size ain't the problem.
I know a stupid outfit when I see one, and when you leave the house looking like that, you deserve whatever ridicule you got coming for it. -
Call me Ishmael. Some years ago–never mind how long precisely–having little or no money in my purse, and nothing particular to interest me on shore, I thought I would roll about a little and see the Walmarty part of the world. It is a way I have of driving off the spleen and regulating the circulation. Whenever I find myself growing grim about the mouth; whenever it is a damp, drizzly November in my soul; whenever I find myself involuntarily pausing before coffin warehouses, and bringing up the rear of every funeral I meet; and especially whenever my hypos get such an upper hand of me, that it requires a strong moral principle to prevent me from deliberately stepping into the street, and methodically knocking people's hats off–then, I account it high time to get to Walmart as soon as I can.
Go home, http://www.itsroundanditswhite.co.uk, you are drunk.
Frosty the Snowwoman
Frosty the snowwoman was a jolly happy soul,
With a corncob larynx and a buttoned bodysuit
And a hairdo made out of coal.
Frosty the snowwoman is a fairmaiden, they say,
Se was made of snow but the People of Walmart
Know how she came to shop one day.
There must have been some puking in that
Old walmart store…..blah blah blahYou finish it, I'm disgusted.


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Women's Hoka One One Stinson TarmacItem #HKA121
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Product Description:Women's HOKA ONE ONE® STINSON TARMAC :: If you're a road runner but like to mix it up by hitting the trails and off-road surfaces when the mood strikes, the Women's Hoka One One® Stinson Tarmac just may be your perfect running shoe! Score an amazingly smooth, yet incredibly efficient ride from the unique Hoka One One® signature design that works to reduce stress on your body, much like full-suspension on a mountain bike. You'll enjoy responsive cushioning and stability unlike anything else in the Stinson Tarmac, plus you'll get plenty of aggressive traction, making it the ideal shoe for ultrarunners, marathoners, triathletes or anyone who likes to explore roads and trails alike. 9.7 ounces Category Type:
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Comments about Womens Hoka One One Stinson Tarmac Running Shoe: I am 60 with good knees. When I run in these my legs feel 20 years younger. I like to think these type of shoes will keep me running longer into my sixties.
Best Uses
Comments about Womens Hoka One One Stinson Tarmac Running Shoe: I love these shoes - great for running on roads or trails - its kind of like having a full suspension mountain bike on your feet. My one negative is that I am a supinator/under-pronator and this shoe is allowing my worst foot to supinate more than my other shoes. I still wouldn't trade them in for another!!
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Comments about Womens Hoka One One Stinson Tarmac Running Shoe: 7 weeks ago I tore my hamstring and havent been able to get back to running to train for an Ironman race in June. Saw these, tried them and wham, back into it. They cushion the impact so much my hamstring isnt sore, my leg fatigue is less and recovery much faster. I liked the Stinson Tarmac as they cushtioned more than the Bondi under the ball of the foot. I needed one full size less (8.5 instead of 9.5). Cant wear thick socks with them but who cares my feet and legs arent sore any more. They are light weight and I think they look good too. Keep up the nazzy colours, everyone's doing colour nowadays.
Cons Best Uses
Comments about Womens Hoka One One Stinson Tarmac Running Shoe: I am an ultra-runner and running on any kinds of trails. I've tried many trail shoes and this is the best I've ever had!!! I have to go 1 size down compared to my regular running shoes, but they fit perfectly. I put my insoles and have no complaints for arch support. I just ran 100K race (+15 hours) with these shoes and had no problems. Some people say wearing these shoes are like being on marshmallows, but I don't really feel that way, probably because I don't wear minimum shoes regularly. I feel less impact to my knees and back. You can't do heel-strike with these shoes, so you can learn how to run with forefoot/midfoot. Good traction even on sandy/rocky slippery terrain. No pain on brutally rocky trails. I would never go back other shoes but these HOKA ONE ONE!!!
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Comments about Womens Hoka One One Stinson Tarmac Running Shoe: I was so excited to try these--but you can have them back. Not enough arch support, heel very sloppy--felt like a man's shoe. The cushioning was nice for the first mile, then it felt like I was running on cushioned lead weights. The shoe is ugly as well, but I was willing to look past that. Sorry, going back to my Nike Pegasus--no Hokas for me!
Displaying reviews 1-5 Your Help Is HereShop with confidence knowing your team of Fit Experts is waiting to answer all your questions. You can always find your perfect product and your perfect fit. Your Road Runner Sports Fit Experts will make sure you get exactly what you want and have tons of fun in the process! Give us a call, chat, or email! Call 800-743-3206 to
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Lincoln Man Convicted of Receipt & Distribution of Child Pornography
United States Attorney Deborah R. Gilg announced that Robert M. Kilts of Lincoln, Nebraska, was sentenced today to 72 months in prison by United States Senior District Judge Richard G. Kopf, for receipt and distribution of child pornography. In addition to incarceration, Kilts was ordered to pay a $100.00 special assessment and will be on supervised release for five years after his release.
In June of 2011, investigators with the Lincoln Police Department discovered numerous files of child pornography that were being shared from an IP address which was registered to Kilts. A search warrant was issued, and investigators discovered over 30 video files on Kilts' home computer. Kilts was also in possession of external hard drives which had contained additional child pornography which had been deleted by a file "wiping" program.
This case was brought as part of Project Safe Childhood, a nationwide initiative to combat the growing epidemic of child sexual exploitation and abuse launched in May 2006 by the Department of Justice. Led by United States Attorneys' Offices and the Criminal Division's Child Exploitation and Obscenity Section (CEOS), Project Safe Childhood marshals federal, state and local resources to better locate, apprehend and prosecute individuals who exploit children via the Internet, as well as to identify and rescue victims. For more information about Project Safe Childhood, please visit www.projectsafechildhood.gov.
This case was investigated by the Lincoln Police Department.


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Overall: | B |
Violence: | A- |
Sexual Content: | B |
Language: | A- |
Drugs/Alcohol: | B- |
Theater Release: | |
Video Release: | 31 Oct 2005 |
MPAA Rating: | |
See Canadian Ratings | |
How We Determine Our Grades |
The Perfect Man is rated PG: for some mildly suggestive content.
Cast: Hillary Duff
Studio: 2005 Universal Studios
Detailed Review
Moving is second nature to Holly Hamilton (Hilary Duff). She's packed and unpacked many times in her scant seventeen years of life... and she's about to do it again…
Read our complete review on this movie. »
Talk It Over
Internet safety is an ongoing problem. Parents sharing this movie with their children may…
Get complete discussion ideas and "Talk It Over" with your family. »
Video alternatives / Home Video Bonus Features
Hillary Duff plays another character that uses the Internet to find the perfect prince…
Click for more movie ideas and info on bonus features. »


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We spent 1 night at this motel and it was fine. The receptionist was very friendly and welcoming. The room was quite clean and comfortable, very quiet despite most of the rooms being occupied. It's definitely not a luxury place, but for the money, it was a good value. The shower worked well and the bed had a pillow top,... More
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130 Jubilee Rd Bridgewater, NS South Shore
Barb Thompsont: 902-543-4033e: bridgewater.ca
Open year-round
Located in Bridgewater on the South Shore, DesBrisay Museum offers exhibits on the natural history, early settlement, and cultural and industrial growth of Lunenburg County from the early 17th century. Our museum includes a permanent Heritage Gallery with nine exhibits; a Folk Art Gallery; Research Centre, and a Gift Shop. Researchers are welcome; an appointment is recommended. Bus tours are welcome. Our facility is "senior-friendly", with easy-to-read information in the displays and more accessible washrooms.DesBrisay Museum is situated in a 25-acre park with a picnic area, walking trails and a large duck pond – a great place to explore nature!
phone or check website for hours.
Details: Admission charged.
DesBrisay Museum and Exhibit Centre


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promotional discount applied. Cart total will reflect savings.
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This product may only be purchased with the approval of a veterinarian and may require verification. We will collect any necessary information at checkout and verify a prescription if required.
Sometimes, manufacturers require that products be advertised only at their suggested prices. When we choose to sell these items for less, we display the sale price only in the cart. To see the price, click Add to Cart.
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Ingredients Extruded Soy Bean Meal, MonoCalcium Phosphate, Salt, Calcium Carbonate, Ascorbic Acid, L-Lysine Hydrochloride, Yeast Extract, Dextrose, dl-Alphatocopherol Acetate (source of Vitamin E Activity), dl-Methionine, Potassium Chloride, Linseed Meal, Ferrous Sulfate, Zinc Proteinate, Choli
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Women's Brooks Ravenna 5Item #BRK1125
Reg: $109.95
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Product Description:Women's BROOKS® RAVENNA 5 :: Get the same soft yet supportive feel you came to expect from previous Ravenna generations, while scoring a more customized fit and smoother than ever transitions in the newly updated Women's Brooks® Ravenna 5. Treat your feet to the new uber-comfortable, mold-to-your-foot support of the BioMoGo DNA cushioning, and move silky smooth through every stride protected by the updated crash pad of this running shoe. You can count on getting that same great support for mild pronation and the easy flex you loved in the Ravenna 4, while enjoying an updated look with the bright new colors of the Ravenna 5. 8.5 ounces Category Type:
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Comments about Womens Brooks Ravenna 5 Running Shoe: As a former Asics GT-2000 girl, I can say that I am now completely hooked on the Brooks Ravenna. I loved the Ravenna 4 and completed a marathon in those with no issues, but so far I'm loving the Ravenna 5's even more. They definitely have a lighter feel, and seem more comfortable through the arch. The toebox is nice and roomy but the rest of the shoe fits snugly enough that I don't feel like I have to cinch the laces too tightly for a good fit the way I do with other brands. So far I have worn them on the track, treadmill, and in outdoor wintery conditions, and they have felt great on all surfaces...Keep up the great work, Brooks!
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Comments about Womens Brooks Ravenna 5 Running Shoe: I have these in my rotation with the Mizuno Wave Inspire 10s. I feel like these have a bit more cushion than the Mizunos. I had the Ravenna 4 before this model and can definitely feel the improvements - better support and so lightweight. I can't wait for the weather to improve so I can finally run outside (stupid asthma!).
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Comments about Womens Brooks Ravenna 5 Running Shoe: Great running shoe...none better. 4th year for Ravenna's for me. Will continue to buy.
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Comments about Womens Brooks Ravenna 5 Running Shoe: Lightweight and very comfortable! I love the amount of toe space-as well as overall arch support. I first tried these on at Roadrunner and knew that--despite the stack of options beside me--I would be walking out with these on. I tried the others on (including a pair of asics and another pair of Brooke's that came close), but nothing quite compared to these.
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Comments about Womens Brooks Ravenna 5 Running Shoe: I bought these at the Tualatin OR store after a shoe dog fitting. I was recommended the Brooks Ravenna 5, the Mizuno Wave Inspire 10 and the Asics GT 2000. More than the other two, the Ravenna 5 was the most comfortable and felt the most stable when running through the store. Granted, I didn't road test them before purchase, but I've done some outside running in them since and have been quite happy with the fit and stability--they truly do enable a smoother-feeling run!
Displaying reviews 1-5 Watch the Women's Brooks Ravenna 5 Video!Women's Brooks Ravenna 5 Video Description:You have to see the Women's Brooks Ravenna 5 in action! Watch the video, and take advantage of Jessica's expert knowledge as she shows you everything you need to know about the Women's Brooks Ravenna 5, including how you'll love the BioMoGo DNA, adjustable saddle, Flextra rubber, Omega Flex Grooves in the forefoot, and the added stability of the Rollbar. Your Help Is HereShop with confidence knowing your team of Fit Experts is waiting to answer all your questions. You can always find your perfect product and your perfect fit. Your Road Runner Sports Fit Experts will make sure you get exactly what you want and have tons of fun in the process! Give us a call, chat, or email! Call 800-743-3206 to
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This fawn was see 4hrs after is was born. It has been hanging around our "neck of the 40" for the whole month.
We new is was no more than 4hrs old when we sent a pic to the DNR and they let us know.
It's a Boy.... or is it a Girl?
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Tag Archives: fil am comedy
Room to Improv January Show! Bringing in 2013!
What is up, Los Angeles! Who's ready for some short-form improvisation!? You've survived the Mayan Apocalypse! You've survived holiday shopping! You've survived New Year's Eve! It's time to kick up them aching dogs and relax. What better way to kick … Continue reading


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Future Scientists, Engineers & Mathematicians:
High School Juniors and Seniors are needed to assist at our Mad Scientist Mondays next September and October at the Bloomfield Township Public Library. You will be asked to demonstrate our new science kits to other students. Community service credit is available. Please fill out the Volunteer Application [1]available at the Library's Welcome Desk.
[1] http://www.btpl.org/sites/default/files/uploads/Volunteer%20Application%2012-%202010.pdf
[2] http://www.btpl.org/sites/default/files/uploads/science icon.jpg


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Print friendly version
Rotor syndrome
Other Names for this Disease
- Hyperbilirubinemia, Rotor type
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
[1][2] Rotor syndrome is caused by mutations in the SLCO1B1 and SLCO1B3 genes. Mutations in both genes are required for the condition to occur.[3][4] This condition is inherited in an autosomal recessive fashion.[1][2]
Rotor syndrome is a hereditary disorder of bilirubin metabolism. In Rotor syndrome there is an increase in the amount of bilirubin in the blood (hyperbilirubinemia). Rotor syndrome is characterized by jaundice, which is a yellowing of the skin and whites of the eyes.
Last updated: 12/12/2013
- Strassburg CP. Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome). Best Pract Res Clin Gastroenterol. 2010 Oct;
- Crawford JM, Liu C. Liver and Biliary Tract. In: Kumar eds.,. Robbins and Cotran Pathologic Basis of Disease, Professional Edition , 8th ed. Philadelphia, PA: Saunders; 2009;
- Rotor syndrome. Genetics Home Reference (GHR). March 2013; http://ghr.nlm.nih.gov/condition/rotor-syndrome. Accessed 12/12/2013.
- Hyperbilirubinemia, Rotor Type. Online Mendelian Inheritance in Man (OMIM). July 2013; http://omim.org/entry/237450. Accessed 12/12/2013.
Your Questions Answered
by the Genetic and Rare Diseases Information Center2 question(s) from the public on Rotor syndrome have been answered. See questions and answers. You can also submit a new question.
On this page
Basic Information
- Genetics Home Reference (GHR) contains information on Rotor syndrome. This website is maintained by the National Library of Medicine.
In Depth Information
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Rotor syndrome. Click on the link to go to OMIM and review these resources.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Rotor syndrome. Click on the link to view a sample search on this topic.


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Courtney Sluke and Justin Traeger announce their engagement and forthcoming marriage. Their parents are Daniel and Nedra Sluke, Minot, and Rick and Diane Traeger, Glasgow, Mont.
She graduated from Minot High School in 2007 and attends Minot State University, where she is pursuing a degree in elementary education. She is a before and after school aide at Washington Elementary School in Minot.
He graduated from Glasgow High School in 2001 and from Minot State University in 2009 with a criminal justice degree. He is currently employed by the Ward County Jail.
A Saturday, Aug. 7, wedding is planned for 3:30 p.m. in First Lutheran Church in Minot. The reception and dance will follow at 5 p.m. in The Vegas Motel in Minot.


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Science in the Parks is an interactive outreach program for children of all ages, especially preschool through middle school, as well as their families. The free program visits six parks each summer in the Ogden area, in conjunction with Ogden School District's free summer lunch program. Each week we visit a different park, and each day of the week we present a different collection of interactive, playful, and fun science activities.
Our tour is back for the summer of 2013! Here's the list of dates and parks that we'll be at from 11:30-1:00, Monday through Friday, offering free, playful science for families to engage with:
Week of June 10: Lorin Farr Park
Week of June 17: Liberty Park
Week of June 24: Monroe Park
Week of July 1: Jaycee Park (Note: July 4-5 Holiday)
Week of July 8: Mt. Ogden Park
Week of July 15: West Ogden Park
More information:
Here's our map, in case you are looking for what site is closest to your home. And here's a flier you can distribute or put on your refrigerator.
Each day includes a different set of activities including:
See it! | Hear it! | Build it! | Move it! | Feel it!
[We're working on links to each of our themes to give you a more comprehensive list of activities.]
"Like" us on Facebook for updates and other fun discussions.
Or, feel free to contact Adam Johnston (firstname.lastname@example.com, 801.626.7711) with your questions or for more specific details.
Science in the Parks has benefited from past and ongoing support from:
- Weber County R.A.M.P.
- The Utah Families Foundation
- The Val A. Browning Foundation
- The Ott Planetarium
Need more science at home? (Who doesn't?!) We're compiling helpful links and advice for you on our resource page. You're also always welcome to contact us.
And, we're also working on a "Frequently Asked Questions" page, mostly because it's interesting to think about the questions we get asked as well as the questions we think we should get asked.
Did you know that there's an Arts in the Parks program, too? They visit the same parks as us (on different weeks), and we're big fans of what they're doing.
We are always looking for volunteer with us! Fill out this form to let us know what dates you'd like to join us.
Media and Press
With special thanks to Ron Proctor, here's some footage and explanation of the program:
Science in the Parks / Arts in the Parks (HD) from WSU CSME on Vimeo