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Most Popular Comedy Feature Films
1. |
(2013) Fearless optimist Anna teams up with Kristoff in an epic journey, encountering Everest-like conditions, and a hilarious snowman named Olaf in a race to find Anna's sister Elsa, whose icy powers have trapped the kingdom in eternal winter. Dir: Chris Buck, Jennifer Lee With: Kristen Bell, Josh Gad, Idina Menzel Animation | Adventure | Comedy | Family | Fantasy | Musical 102 mins. |
2. |
The Wolf of Wall Street
(2013) Based on the true story of Jordan Belfort, from his rise to a wealthy stockbroker living the high life to his fall involving crime, corruption and the federal government. Dir: Martin Scorsese With: Leonardo DiCaprio, Jonah Hill, Margot Robbie Biography | Comedy | Crime | Drama 180 mins. |
3. |
The Lego Movie
(2014) An ordinary LEGO minifigure, mistakenly thought to be the extraordinary MasterBuilder, is recruited to join a quest to stop an evil LEGO tyrant from gluing the universe together. Dir: Phil Lord, Christopher Miller With: Will Arnett, Elizabeth Banks, Alison Brie Animation | Adventure | Comedy | Family | Fantasy 100 mins. |
4. |
The Grand Budapest Hotel
(2014) The adventures of Gustave H, a legendary concierge at a famous European hotel between the wars, and Zero Moustafa, the lobby boy who becomes his most trusted friend. Dir: Wes Anderson With: Ralph Fiennes, F. Murray Abraham, Mathieu Amalric Comedy | Drama 99 mins. |
5. |
Mr. Peabody & Sherman
(2014) The time-travelling adventures of an advanced canine and his adopted son, as they endeavor to fix a time rift they created. Dir: Rob Minkoff With: Ty Burrell, Max Charles, Stephen Colbert Animation | Adventure | Comedy | Family | Sci-Fi 92 mins. |
6. |
Goodbye World
(2013) James and Lily live off the grid, raising their young daughter in a cocoon of comfort and sustainability... Dir: Denis Hennelly With: Adrian Grenier, Gaby Hoffmann, Ben McKenzie Comedy | Drama |
7. |
Blue Jasmine
(2013) A New York socialite, deeply troubled and in denial, arrives in San Francisco to impose upon her sister. She looks a million, but isn't bringing money, peace, or love... Dir: Woody Allen With: Cate Blanchett, Alec Baldwin, Peter Sarsgaard Comedy | Drama 98 mins. |
8. |
The Art of the Steal
(2013) Crunch Calhoun, a semi-reformed art thief, agrees to get his old gang back together to pull off one last heist. Dir: Jonathan Sobol With: Kurt Russell, Jay Baruchel, Katheryn Winnick Comedy | Crime 90 mins. |
9. |
Veronica Mars
(2014) Years after walking away from her past as a teenage private eye, Veronica Mars gets pulled back to her hometown - just in time for her high school reunion - in order to help her old flame Logan Echolls, who's embroiled in a murder mystery. Dir: Rob Thomas With: Kristen Bell, Jason Dohring, Enrico Colantoni Comedy | Crime | Drama 107 mins. |
10. |
Saving Mr. Banks
(2013) Author P.L. Travers reflects on her childhood after reluctantly meeting with Walt Disney, who seeks to adapt her Mary Poppins books for the big screen. Dir: John Lee Hancock With: Emma Thompson, Tom Hanks, Annie Rose Buckley Biography | Comedy | Drama | History | Music 125 mins. |
11. |
Grown Ups 2
(2013) After moving his family back to his hometown to be with his friends and their kids, Lenny finds out that between old bullies, new bullies, schizo bus drivers, drunk cops on skis, and 400 costumed party crashers sometimes crazy follows you. Dir: Dennis Dugan With: Adam Sandler, Kevin James, Chris Rock Comedy 101 mins. |
12. |
The Great Beauty
(2013) Jep Gambardella has seduced his way through the lavish nightlife of Rome for decades, but after his 65th birthday and a shock from the past, Jep looks past the nightclubs and parties to find a timeless landscape of absurd, exquisite beauty. Dir: Paolo Sorrentino With: Toni Servillo, Carlo Verdone, Sabrina Ferilli Comedy | Drama 142 mins. |
13. |
Ride Along
(2014) Fast-talking security guard Ben joins his cop brother-in-law James on a 24-hour patrol of Atlanta in order to prove himself worthy of marrying Angela, James' sister. Dir: Tim Story With: Ice Cube, Kevin Hart, Tika Sumpter Action | Comedy 99 mins. |
14. |
Muppets Most Wanted
(2014) While on a grand world tour, The Muppets find themselves wrapped into an European jewel-heist caper headed by a Kermit the Frog look-alike and his dastardly sidekick. Dir: James Bobin With: Tina Fey, Ricky Gervais, Ty Burrell Adventure | Comedy | Crime | Family | Musical 112 mins. |
15. |
Rio 2
(2014) It's a jungle out there for Blu, Jewel and their three kids after they're hurtled Rio de Janeiro to the wilds of the Amazon... Dir: Carlos Saldanha With: Rodrigo Santoro, Anne Hathaway, Jesse Eisenberg Animation | Adventure | Comedy | Family 101 mins. |
16. |
About Last Night
(2014) Follow two couples as they journey from the bar to the bedroom and are eventually put to the test in the real world. Dir: Steve Pink With: Kevin Hart, Michael Ealy, Regina Hall Comedy | Romance 100 mins. |
17. |
Silver Linings Playbook
(2012) After a stint in a mental institution, former teacher Pat Solitano moves back in with his parents and tries to reconcile with his ex-wife. Things get more challenging when Pat meets Tiffany, a mysterious girl with problems of her own. Dir: David O. Russell With: Bradley Cooper, Jennifer Lawrence, Robert De Niro Comedy | Drama | Romance 122 mins. |
18. |
Anchorman 2: The Legend Continues
(2013) With the 70s behind him, San Diego's top rated newsman, Ron Burgundy, returns to take New York's first 24-hour news channel by storm. Dir: Adam McKay With: Will Ferrell, Christina Applegate, Paul Rudd Comedy 119 mins. |
19. |
(2013) Revolves around a family struggling to maintain their well-to-do lifestyle in their overly materialistic New England community... Dir: Jay Alaimo With: Kyra Sedgwick, Vincent D'Onofrio, Tom Sizemore Comedy | Drama 93 mins. |
20. |
Movie 43
(2013) A series of interconnected short films follows a washed-up producer as he pitches insane story lines featuring some of the biggest stars in Hollywood. Dir: Elizabeth Banks, Steven Brill With: Emma Stone, Stephen Merchant, Richard Gere Comedy 94 mins. |
21. |
Don Jon
(2013) A New Jersey guy dedicated to his family, friends, and church, develops unrealistic expectations from watching porn and works to find happiness and intimacy with his potential true love. Dir: Joseph Gordon-Levitt With: Joseph Gordon-Levitt, Scarlett Johansson, Julianne Moore Comedy | Drama | Romance 90 mins. |
22. |
This Is the End
(2013) While attending a party at James Franco's house, Seth Rogen, Jay Baruchel and many other celebrities are faced with the apocalypse. Dir: Evan Goldberg, Seth Rogen With: James Franco, Jonah Hill, Seth Rogen Comedy | Fantasy 107 mins. |
23. |
Last Vegas
(2013) Three sixty-something friends take a break from their day-to-day lives to throw a bachelor party in Las Vegas for their last remaining single pal. Dir: Jon Turteltaub With: Robert De Niro, Michael Douglas, Morgan Freeman Comedy 105 mins. |
24. |
(1984) Three unemployed parapsychology professors set up shop as a unique ghost removal service. Dir: Ivan Reitman With: Bill Murray, Dan Aykroyd, Sigourney Weaver Comedy | Fantasy | Sci-Fi 105 mins. |
25. |
Magic Mike
(2012) A male stripper teaches a younger performer how to party, pick up women, and make easy money. Dir: Steven Soderbergh With: Channing Tatum, Alex Pettyfer, Olivia Munn Comedy | Drama 110 mins. |


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Professor J. Calvin Jarrell can't help but speak in dramatic terms about a music and dance production that's being staged at Southern Illinois University Edwardsville this week.
"It started as a labor of love and then it became of project of passion and then it turned into an object of obsession," he said.
"Carmina Burana" pairs SIUE students in choral, orchestra and dance programs with a choreographer, conductor, singers and dancers from Cuba.
Jarrell, 61, of Edwardsville, director of the SIUE dance program, has been planning it for two years.
"Nothing like this has ever been done at SIUE," he said. "I'm not even sure any institution in the United States has ever attempted anything like it. It was like a giant monster with tangled hair that didn't want to be combed."
Jarrell was referring to red tape involved in bringing Cuban artists to a country that has enforced a commercial, economic and financial embargo for more than 50 years.
"It was incredibly complex," he said, noting he couldn't even send money to the Cubans directly for transportation.
"Carmina Burana" (Latin for "Songs from Beuern") originated as Medieval poems and dramatic texts discovered in a Bavarian monastery in 1803. German composer Carl Orff turned 24 of them into songs in the 1930s.
"His selections cover a wide range of topics, such as wealth, the ephemeral nature of life, the joy of the return of spring and the pleasures and perils of drinking, gluttony, gambling and lust," according to a press release.
"Much of his 'O Fortuna,' the opening piece in his master work, is easily recognizable by most people as one of the most often used pieces of music in the 20th century."
Choreographer Alfredo Velazquez Carcasses gave the dances a Cuban-Caribbean flavor for the SIUE production. Jarrell added a prelude with four Cuban pieces, which will be performed by an orchestra conducted by Cosette Justo Valdes, followed by Cuban and American dance numbers.
Valdes noted that Cubans know much more about U.S. culture than Americans know about Cuban culture, and that people at SIUE have been friendly and eager to learn.
"I have a very nice impression (of the United States)," she said. "I like the people very much. I love the music."
Jarrell has traveled to Cuba 18 times in six years to do scholarly research on that country's culture, specifically music and dance.
"I fell in love with the place the minute I stepped off the plane," he said. "It's just alive with energy and passion and the arts."
Jarrell quickly got acquainted with Oscar Julio Mesa Menzies, a representative of a Cuban artists' union in Santiago. They became close friends.
Menzies later helped Jarrell plan the "Carmina Burana" production at SIUE. They saw it as tool for multi-cultural, cross-disciplinary learning.
"I wanted to bring the experience to the region," Jarrell said. "Most people know very little about Cuba. They don't know how rich the culture is, how wonderful the people are and how beautiful the country is."
Tragedy struck in January, when Menzies died suddenly of a cerebral hemorrhage at 59. It dampened Jarrell's spirits, but the show had to go on.
The Cuban artists arrived in Edwardsville last month. Things seemed to be going smoothly until April 2, when Jarrell suffered a stroke. It was treated quickly but caused him to miss a week of rehearsals. Carcasses had to substitute.
"Everybody pulled together to make this thing happen," said Jarrell, who is well on his way to recovery. "It was almost like divine intervention because the multi-cultural cooperation that I wanted in the first place happened because I wasn't there."
At a glance
What: "Carmina Burana"
Who: SIUE dance students and Cuban artists
When: 7 p.m. Friday and Saturday (tonight's dress rehearsal at 7 also is open to the public)
Where: Katherine Dunham Theater on the SIUE campus
Admission: $24 ($12 for tonight's dress rehearsal)
Tickets: Call the SIUE box office at 618-650-2774 or email email@example.com
Information: www.siue.edu/artsandsciences/theater

subset: commoncrawl


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KRWG.ORG-The Region's Home Page
2:56 pm
Fri February 22, 2013
Shocking Allegations Over Minimum Wage Battle In ABQ
An Albuquerque restaurant owner who says he's not going to comply with the city's new higher minimum wage is back in the news.
KRQE-TV says Eric Szeman's son showed up at the home of a restaurant server with a baseball bat and machete.
The employee — Kevin O'Leary — went public with the Route 66 Malt Shop not complying with the wage law.
O'Leary says he was surprised when Andrew Szeman showed up at his Albuquerque home last Sunday afternoon.
The TV station says Andrew Szeman is the restaurant's manager.
He says he just went to talk to O'Leary. O'Leary says Szeman left after he called police.
Eric Szeman says he didn't know his son was going to confront O'Leary.
O'Leary says he plans to get a restraining order.
Information from: KRQE-TV, http://www.krqe.com
Copyright 2013 The Associated Press.


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Wharfedale Diamond 10.MX
Where bass is concerned it's certainly got quantity, and to a great extent the Wharfedale has the quality, too
Write your own reviewFor
- Digs deep, hits hard
- good tonal variation with music
- wide choice of finishes
- Not as quick as it might be where music is concerned
- some chuffing from reflex-port at volume
After an ensemble outing in our November 2009 issue, Wharfedale's partially shiny Diamond 10.MX emerges from its position as part of the Diamond 10 HCP multi-channel speaker package and steps into the spotlight.
Should you shine a spotlight on it, though, be aware that the glossy front plate is as keen on collecting fingerprints as any of the characters on CSI.
Otherwise it's smart enough, with both speaker and line-level inputs, crossover control from 35 to 85Hz, 5V USB output should you wish to drive it wirelessly, and a choice of seven finishes.
Pounding performer
As far as multiplex action movies go, the Wharfedale delivers plenty of presence for your money.
The splendid Blu-ray transfer of Heat is meat and drink to the Diamond 10.MX – it pounds through the many gunshots and explosions with relish and vigour, delving deep down the frequency range to elicit the sort of rumble and slap that could easily provoke the neighbours.
In terms of extension and attack, the Wharfedale bears comparison to the best £300-ish subwoofers around.
Switch to the altogether trickier task (for subwoofers, at least) of reproducing music and the Wharfedale's modus operandi alters not a jot.
Handy with music too
The bassline in Kanye West's Love Lockdown is cavernously deep and enjoys decent tonal variation, too – the Diamond 10.MX is hard-hitting, but not mindlessly so.
There's a little reluctance to really attack the leading edges of fast-moving low frequency information, though, which can make the sound: a) fractionally slow; b) fractionally muddled; c) a bit of both.
Our sample also suffered from some reflex-port 'chuffing', which inhibited the volume at which it could be played – a shortcoming we haven't heard in a sub for quite some time.
But this happens only at very high volumes, and isn't a problem when playing at normal volume levels. All in all, this subwoofer has plenty to recommend it.
See all our subwoofer Best Buys


text:
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This 1973 Datsun 240Z has a 146 C.I. (150 HP) Inline 6 CylinderDual SU CarburetorsUpdated 5 Speed Manual TransmissionIndependent Rear End w/ 3.54:1 RatioEnkei... More


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When you sign-up for TuneCore Music Publishing Administration and add your compositions, the compositions you distribute through TuneCore will be included in our invite-only Synchronization & Master Licensing Database. This exclusive, online Database is available only to Music Supervisors and allows them to listen to the recordings of your compositions. We make it easy for Music Supervisors to find your music, allowing them to search by keyword, genre, iTunes sales rank at TuneCore, song title, writer, and artist. These search parameters give Music Supervisors the freedom to find any composition within our Database that suits their needs and request a license for the use—from there, our in-house licensing department handles all negotiations and licensing on your behalf.
Learn More10 Key Reasons to Get a Publishing Deal from TuneCore
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text: Main Content Act 295 of 1976 friendly link Printer Friendly bills affecting index and updates Search within this Statute for STATE TRANSPORTATION PRESERVATION ACT OF 1976Act 295 of 1976AN ACT to improve and maintain transportation services in this state; to provide for the acquisition and use of funds; to provide for the acquisition of certain railroad facilities and certain property; to provide for the disposition and use of facilities and property acquired under this act; to provide for financial assistance to certain private transportation services; to prescribe the powers and duties of certain state departments and agencies; to provide for the transfer of certain funds; to provide for the creation of certain funds; and to provide for appropriations. History: 1976, Act 295, Eff. Nov. 15, 1976 ;-- Am. 1981, Act 129, Imd. Eff. Sept 30, 1981 ;-- Am. 1982, Act 288, Imd. Eff. Oct. 7, 1982 ;-- Am. 1984, Act 210, Imd. Eff. July 9, 1984 ;-- Am. 2001, Act 126, Imd. Eff. Oct. 15, 2001 © 2009 Legislative Council, State of MichiganThe People of the State of Michigan enact: DocumentTypeDescription Section 474.51SectionShort title; declaration of public purpose. Section 474.52SectionDefinitions. Section 474.53SectionRepealed. 1998, Act 235, Imd. Eff. July 3, 1998. Section 474.54SectionPowers of department generally. Section 474.55SectionFinancial assistance for railroad or street railway; department as agent. Section 474.56SectionAcquisition of railroad property or other property; condemnation. Section 474.57SectionExpired. 1976, Act 295, Eff. Dec. 31, 1976. Section 474.58SectionNotice of abandonment; acquisition of rights of railroad company by state department of transportation or department of natural resources; warranty or quitclaim deed; acquisition of rights in rights of way approved for abandonment. Section 474.59SectionCooperation and contractual arrangements with other states and dominion of Canada; acquisition of trackage rights and rail property in other states and dominion of Canada. Section 474.60SectionAcquiring, leasing, or securing easement for use of real property owned by railroad; conveyance or lease to public or private entity; divestiture or creation of leases; determination of sale terms; exceptions; order of parties to be offered lease; reversion; submission of financial statement and operation plan; "tributary lines" defined; return of proceeds to state; action for relief; determination of lease terms; jurisdiction; preservation of right-of-way for future use as railroad line; disposing of or leasing right-of-way; powers of department; restrictions to assure future rail use. Section 474.60aSectionIssuance of statement regarding segment viability. Section 474.60bSectionPrequalification; requirements. Section 474.60cSectionPrequalification; appeal of committee decision; definitions. Section 474.60dSectionPrequalification; appeal of panel decision. Section 474.60eSectionDivestiture of segment; proposals; scoring mechanism; contents of proposal; availability of information to bidder. Section 474.60fSectionApplication of scoring mechanism; opening sealed envelope; evaluation of proposal; selection of bidder; failure of bidder to accept award; retention of guaranty as liquidated damages; return of certified checks or surety bonds to unsuccessful bidders; agreement. Section 474.60gSectionReplacement operator. Section 474.61SectionFederal funds; public or private grants, gifts, donations, or appropriations. Section 474.62SectionFederal loan, guarantee of loan, or federal programs. Section 474.63SectionRepealed. 1981, Act 129, Eff. Oct. 1, 1981. Section 474.64SectionAcquisition of intercity bus and ferry equipment and facilities. Section 474.65SectionModernization, rehabilitation, rebuilding, and relocation of rail property; maintenance and improvements. Section 474.65aSectionRail infrastructure loan fund. Section 474.66SectionContracts for rail, street railway, intercity bus, or ferry service. Section 474.67SectionFinancial assistance for facilities of rail freight and marine freight transportation; deposit of funds to be held as separate fund; rail freight fund; administration. Section 474.67aSectionSoo Locks fund. Section 474.68SectionTermination of rail freight services; contracts for substitute services and relocation assistance. Section 474.69SectionRepealed. 1984, Act 210, Imd. Eff. July 9, 1984. Section 474.69aSectionCompliance. Section 474.70SectionEffective date.


text:
Online Classifieds
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The Observer
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Breaking News from the Associated Press at the New York Times
Vol XXXIV No. 12
Thursday, September 7, 2000
Quote of the Day
Graham Greene
"As a Roman Catholic I thank God for the heretics. Heresy is only another word for freedom of thought." Graham Greene author ...
Political Face-Off
Delineating the 2000 candidate platforms
Liam Brennan
College Democrats
On January 20, the United States will once again witness one of its great ceremonial institutions. On that day, notwithstanding some immanent revolution, the country will witness the peaceful transfer of power from President Clinton to the still unchosen president-elect. From ...
Political Face-Off
Delineating the 2000 candidate platforms
Greg Kelly
College Republicans
Prosperity, growth and opportunity have characterized the last eight years in our nation. These successes are attributed to no one party, but rather they are the result of bipartisan cooperation and interest in the American people. Yet there is nothing the ...
Correcting lethal injection process error
Stephen Carroll
I am writing in reference to the viewpoint by Lauren Jiltoy in Wed., Sept. 8 issue of The Observer titled "Protesting death as punishment." Without getting into a long and drawn out argument on the death penalty I would like to ...
A Basic Instinct
Mike Connolly
Editor In Chief
I had just climbed into my truck in the Walgreens parking lot on 31 and was about to start the engine when I heard a voice outside my door. I looked up and a man was standing just outside my window. ...


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"One more graph for you to look at. I revised the actual read dates as you suggested and added…"
Tamasin Sterner doesn't have any friends on Home Energy Pros yet.
Home Energy Pros was founded by the developers of Home Energy Saver Pro (sponsored by the U.S. Department of Energy,) and brought to you in partnership with Home Energy magazine.
© 2014 Created by Lawrence Berkeley National Laboratory.


text:
NAICS 22131: Water Supply and Irrigation Systems
This industry comprises establishments primarily engaged in operating water treatment plants and/or operating water supply systems. The water supply system may include pumping stations, aqueducts, and/or distribution mains. The water may be used for drinking, irrigation, or other uses.
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Big Digits Tickets
Sorry! Looks like there aren't any events.
But it's not the end of the world! Click Track above and you'll be the first to know when Big Digits tickets are available.
Past Tour Dates for Big Digits
Big Digits Tour Dates 2012
date city state venue 12/12/2012 Cambridge MA Middle East - Downstairs 08/23/2012 Boston MA Brighton Music Hall


text: Brian Burke is a clinical psychologist whose principal academic interests include terror management theory, motivational interviewing, and college teaching. Dr. Burke has published the lead article in the Journal of Consulting and Clinical Psychology that featured a meta-analysis of studies evaluating the efficacy of motivational interviewing. Motivational interviewing is a promising and relatively new treatment for substance abuse and other problem behaviors that combines the humanistic elements of client-centered therapy (Carl Rogers) with more active strategies (e.g., cognitive-behavior therapy) designed to facilitate human change. Dr. Burke has brought this exciting new treatment to FLC in his Counseling Skills class as well as his work the Wellness Peer Educators. Further, Dr. Burke has a degree in college teaching and regularly attends teaching conferences, twice winning the Doug Bernstein Poster Award for innovative teaching ideas, and winning the New Faculty Teaching Award at Fort Lewis College in 2005. Dr. Burke recently completed a meta-analysis of terror management theory (TMT), which hypothesizes that humans deal with death anxiety by defending or investing in our cultural worldviews. An example of TMT in action is the American reaction post 9/11 (a death prime), which included both worldview investment (e.g., an increase in charitable donations and peace corps applications) as well as worldview defense (e.g., attacking Afghanistan and later Iraq, more hate crimes toward Muslim-Americans). Dr. Burke originally hails from Montreal, Canada, and received his Ph.D. from the University of Arizona in 2003. He has been a licensed psychologist in the State of Colorado since November 2004.


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Beef Recipes
Ahhhhhh, beeeeef. Is there anything more luxurious and decadent than a prime grade dry aged ribeye grilled over high heat? Or a weighty brisket smoke roasted for 12 hours?
Buying Beef: The Zen Of Beef Grades & Labels. Here are the different grades of beef and some important terms you need to know. Read the truth about Certified Angus Beef.
Buying Beef: The Zen Of Beef Cuts. Plenty of photos and three charts that will answer your questions.
Buying Beef: The Zen Of Beef Ribs. There are two important cuts, one is better than the other, and three methods of cooking.
How to Grill Better-Than-Steakhouse Steaks. The secrets of making steaks as great or better than they do in the best expensive steakhouses.
How to Sear A Steak. There are two ways. Watch Meathead and Chef Jamie Purviance go head to head with dueling grills.
Extreme Steak. Here are three unconventional methods for cooking steak that work great.
Recipe: Santa Maria Tri-Tip Steaks (Also Works For Whole Beef Tenderloin). Originally settled by Mexican cowboys called vaqueros, Santa Maria, on California's beautiful Central Coast, has an international reputation for their local specialty, tri-tip steak, the unique grill they invented to cook it, and the clever way they carve it to make it tender.
Recipe: BBQ Beef Ribs. Beef ribs are super when smoke roasted low and slow Texas style.
Recipe: Korean Kalbi - Grilled Beef Ribs. If you've ever been to a Korean restaurant, chances are you've had Kalbi (sometimes spelled Galbi) cooked on a grill right on your table. Kalbi is the Korean word for "rib" and it is beef from short ribs, cut thin, marinated, and grilled very quickly. This is an excellent use of an otherwise tough but tasty cut.
Recipe: Braised Beef Short Ribs Provencal. A great way to tenderize tough cuts is low slow cooking in a flavorful liquid, a process called braising. Grilling and smoking is the first choice in warm weather, but when the snowballs fly, braising is the way to go.
Recipe: Texas Beef Brisket. A whole barbecue beef brisket is a huge clod of cow that comes off the pit almost black, looking more like a meteorite than a meal. But it is not burnt, and beneath the crust is tender, juicy, smoky meat. It is the national food of the Republic of Texas and if you plan to compete in one of the many Kansas City Barbecue Society competitions, you'd better learn how to cook it. I can teach you how.
Recipe: Authentic Baltimore Pit Beef. Pit beef is served in many restaurants, bars, and pubs in the Charm City area, and surprisingly, it is rarely found outside Maryland. It is essentially a juicy roast beef sammich cooked on a grill. But there are tricks to amp it up.
Recipe: Secrets Of Cooking Beef Prime Rib Roast, Strip Loin Roast, Tenderloin, Chuck Roast, Round, Rump Roast, And Other Beef Roasts On The Grill. And This Method Works Indoors If It's Too Cold For You, Wimp. Is there anything more impressive that a big juicy standing beef rib roast? Well it's easy to make outdoors and that I think it tastes better.
Recipe: Crusty Flank Steak. My two favorite steaks: Expensive ribeyes and inexpensive flank steaks. Because I'm a cheap SOB, I cook flank steak a lot more than than I cook ribeye. Flank steaks, sometimes called London Broil steaks, are cheaper because they have very little fat, and they can be chewy if you screw them up. Here's how to get a great meal from this ceap cut.
Recipe: Drunk Chuck. Deep rich flavor from a wine marinade on a cut that may be the best bargain on the steer. Also works well on flank steak.
Recipe: Beef Binghamton Spiedies. Better than kebabs.
Recipe: Chicago Italian Beef Sangwitches. Yes, that's how they pronounce this regional classic on the south side of Chicago. Try my recipe and then go to my favorite beef stands and see if they're any better. I don't think so.
Recipe: The Classic Chicago Hot Dog. There are hundreds of ways to prepare a hot dog, and many cities have their local style. In Chicago, where hot dog stands far out number hamburger joints, there is one classic recipe, and very little variation from it. It is the perfect hot dog. This article has the recipe, my ratings of the best beef frankfurters, and my favorite hot dog stands.
Recipe: Home Made Corned Beef. Why make your own corned beef? You know the answer. It's better. Much better.
Recipe: Corned Beef And Cabbage (New England Boiled Dinner). Don't just toss everything in a pot. Here's how to make the best St. Patrick's Day dinner ever.
Recipe: Close to Katz's Home Made Pastrami. The best pastrami in the world is made at Katz's Delicatessin in NYC. The second best can be at your house.
Recipe: Corned Beef Hash. This is what you do with leftover corned beef, potatoes from your St. Patrick's Day dinner.Recipe: Rockin' Reuben Sandwiches. Can you name a better sandwich. Didn't think so.
Roasted Beef Marrow. In recent years, chefs have brought back an ancient practice, serving roasted beef marrow as an appetizer, called by cowboys Prairie Butter. The smooth, creamy, slightly nutty textures and flavors are hard to dislike, a sort of poor man's foie gras, unless you look into the calorie content.
Recipe: Not An Elitist Jerk Beef Jerky. Jerky is a fun snack, but it is far more versatile than you might imagine. Like BLT sammies? Bench the bacon and play the jerky. Like bacon in your salad? Jerk it and replace it. You get the picture. Many things bacon can do, jerky can do too. Often better! Think of homemade jerky as lowfat bacon. And it is a lot healthier than you think. Start by looking at the ingredient list of a bag of jerky in the store. Now look at the ingredient list in this recipe.
...more to come (to be notified when new recipes and other articles come online, be sure to subscribe to my free, spam free, email newsletter).
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Custom Navy Seals design.
This great product in white from our department Men and T-Shirt category can be printed just for you in the size and style you like. The design Navy Seals - Dark Clothing was created by DesignCentral and uploaded to Spreadshirt for you to have printed on a T-Shirt. Next to a host of other great designs, you can find this Navy Seals - Dark Clothing design in Spreadshirt's Military category. If you are interested in topics like "navy seals" or "seal team", then you'll love Navy Seals - Dark Clothing designs by DesignCentral. Spreadshirt also offers a huge selection of t-shirts, hoodies and accessories for the category Military as well as top "special forces" clothing. DesignCentral's designs have already impressed many of our customers, so we are sure that we've got right stuff for you! Spreadshirt is your address for great designs of all kinds – whether it's "navy seals", "seal team" or "special forces". We are sure that you will find something nice in our shop, there are many amazing Military t-shirts, hoodies or accessories for you to find!Tags: Design ID: 11796082
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This snug-fitting lightweight cotton jersey t-shirt for men has a stylish contoured fit and is ideal for those with a smaller frame. Reinforced shoulder construction maintains shape after repeated washings. Durable double-stitched bottom hem and stretchable cotton collar for lasting comfort and durability. Made from 100% fine combed cotton jersey (except for color code heather gray: 90% cotton, 10% polyester), with a fabric weight of 4.3 oz.*Please be advised that the measurements that are displayed may vary by 1" or less depending upon size and color selected*


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Song Stories
"Wish You Were Here"
Avril Lavigne | 2011
During a concert in Winnipeg, Manitoba, the Canadian rocker told her audience that "Wish You Were Here" was about missing someone. "It's something we all go through in our lives," she added. While many fans assumed this regretful song was about her recent divorce from Sum 41's Deryck Whibley, who produced half of her Goodbye Lullaby album, Lavigne told Rolling Stone the songs on Lullaby were not breakup tunes. "People will make assumptions, but they'd be surprised what certain songs are about," she said. Still, this song's vulnerability marked new territory for the normally feisty pop-punker.
Most Popular Song Stories
"Drifter's Escape"
Jimi Hendrix | 1974 -
"Crosstown Traffic"
The Jimi Hendrix Experience | 1968 -
"Voodoo Chile"
The Jimi Hendrix Experience | 1968 -
"Purple Haze"
The Jimi Hendrix Experience | 1967 -
"All Along the Watchtower"
The Jimi Hendrix Experience | 1968 -
"Kiss From a Rose"
Seal | 1995
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Derry or Londonderry Roots?
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Marchesa Painted Camellia Serving Bowl by Lenox
The foot and rim of this bone china bowl are trimmed in 24 karat gold. In between, you'll find a magnificent floral motif inspired by Marchesa fashion designs. The bowl, which holds a full 7 cups, is ideal for entertaining.
- Crafted of Lenox fine white bone china accented with 24 karat gold
- Dishwasher safe
- Under license by Marchesa, which has reviewed this product for quality and authenticity
- Made in USA
- Length: 13"
- Diameter: 8 1/2"
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Bacon Plush
He looks kinda angry… We always assumed that our bacon felt honored to be eaten and enjoyed
from Etsy
Oh, if only such a wonderful animal existed! You could raise your own in a pool out back!
from Etsy
Bacon Earrings
Warning: likely to increase the chance of ear-nibbling as the evening ensues.
Available from Etsy
another Bacon Pillow!
We've got the pillows, the lampshades, the artwork; now for some bacon couches and bacon curtains, and we've got our whole living room decorated!
buy from Etsy


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Videos: Episode 23 Recap: Duet You Want
Episode 23 Recap: Duet You Want
It was one of the most important nights on The X Factor as our Top 4 battled for a spot in the three-person finale. This jam-packed episode included hilariously embarrassing baby photos, entertaining duets, and moving solos. After a night that Simon Cowell called "by far the best show we made," who would make it into the Season 3 finale?!


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A cellphone based home alarm system.
Title | Author | Description | |
Elgin QA Twin Bell Alarm Clock, Silver | This retro twin bell alarm clock looks like a classic keywind, but it is actually a battery operated clock. The features include a lighted dial on demand, a repeating snooze, and either a bell or beep alarm sound. | ||
Ingraham Clocks 15-396 Ardmore Twin Bell Alarm Clock | Ingraham Clocks 15-396 Ardmore Twin Bell Alarm ClockIngraham Clocks 15-396 Ardmore Twin Bell Alarm Clock Features:; Luminous hands and hour dots; Brass case; White dial face; 6.5" x 4.75" x 2.5"; Alarm | ||
Advance Twin Bell Key wind Alarm Clock | This key wind alarm clock will take you back to the good old days. This is also perfect for the green customer, as it uses no electricity or batteries. | ||
199 Great Home Businesses You Can Start (and Succeed In) for Under $1,000: How to Choose the Best Home Business for You Based on Your Personality Type | Tyler G. Hicks | Turn Your Dream of Starting a Home-Based Business into Reality!It's incredibly easy to start a money-making business right from the comfort of your own home. Millions of people just like you are enjoying the freedom—and extra income—of working for themselves. You can too. In 199 Great Home Businesses You Can Start (and Succeed In) for Under $1,000, home-based business guru Tyler Hicks shows you how to achieve your work-at-home dream.Inside you'll learn the secrets to:·Choosing the home-based business that's just right for you ·Getting started in your business with minimal cost ·Building your fortune doing what you love ·Running a business from home while keeping your day job ·Using the Internet to advertise and promote your home-based business ·And much more!This invaluable book will help you begin your promising new life today as a successful home-based entrepreneur! | |
How to Start a Home-based Bookkeeping Business (Home-Based Business Series) | Michelle Long | In tough economic times and with rising unemployment, people are looking to take the bull by the horns and start their own home-based businesses.... From GPP's enormously successful How to Start a Home-Based Business series (more than half a million copies sold!), comes the essential guide to starting up a home-based Bookkeeping business. | |
How to Start a Home Based Travel Agency | Tom Ogg, Joanie Ogg and Tom | How to Start a Home Based Travel Agency has just been entirely updated. The effects of September 11th, 2001 and the resulting aftermath has had a dramatic effect on the travel industry and further enabled home-based travel entrepreneurs. The January 1st, 2003 printing of How to Start a Home Based Travel Agency is the most up-to-date information available about operating a travel business in this exciting industry. Issues such as the elimination of airline commissions, the implementation of service fees, the fabulous growth of the cruise industry and all of the changes that have evolved are discussed and analyzed. This edition of How to Start a Home Based Travel Agency is a must have if you are considering entering the travel industry or are an agent going home-based from a storefront. | |
How to Start a Home-Based Day-Care Business, 5th (Home-Based Business Series) | Shari Steelsmith | Including guidance on both the financial and educational aspects of running a home-based day-care program, Shari Steelsmith's book offers tips for successful business management as well as advice on caring for children. Suggestions for establishing and maintaining a home-based business, communicating effectively with children, and remediating potential problems are also included. | |
Making Money from Home: How to Run a Successful Home-Based Business | Donna Partow | In tough economic times, conventional jobs can be hard to find. A home-based business could be the answer for many people. Making Money from Home compares the cost of working outside the home with the benefits of working from home. It provides readers with the tools they need to run a successful home business, such as time management advice, details on the foundations of a solid business, tips on marketing goods and services, legal issues to consider, and information on how to use the Internet effectively and how to create a business plan. | |
How to Start a Home-Based Bakery Business (Home-Based Business Series) | Detra Denay Davis | Home-based baking is one of America's best-kept business secrets. This sleeper industry offers even novice bakers the opportunity to bake from home for profit using tried and true recipes and equipment already on hand. And yet its many rules and how-tos are so elusive that few people out there who love to bake and dream of taking their products from the kitchen to the market actually end up doing so. Enter How to Start a Home-Based Bakery Businessthe first book to cover every essential aspect of planning, starting, and running such a business successfully. | |
Home-Based Business For Dummies | Paul Edwards, Sarah Edwards and Peter Economy | Expert tips and advice on starting a home-based businessStarting your own home-based business is a great way to supplement your income in these tough economic times. With thirty percent new and revised material, Home-Based Business For Dummies, 3rd Edition gives you the most current and up-to-date information you need to navigate your way through the whole process.You'll get trusted and creative advice on how to start being your own boss, bringing in a steady paycheck, and running a business you'll enjoy.Complete coverage of legal and financial aspects of a home-based businessEffective advertising and promotional strategies that won't break the bankTips and information you need to make your business profitableAdvice on outfitting and running a home office Whether you've been affected by downsizing in these uncertain times or are just looking to earn some extra cash, Home-Based Business For Dummies, 3rd Edition shows you how to avoid scams and truly start working from home for profit. |
Tags | alarm home |
Address |
Telephone | 866-641-6599 |
Web | my-alarm.com | Type | Business Opportunity |


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Sending the same ornament to different places? If you order more than one of an item and want them shipped to different addresses, please order them individually. We will ask you for the individual shipping addresses later in the ordering process.
Golf Shoe Christmas Ornament
Personalized Christmas Ornament
Material: Glass - Old World Christmas
and credit card.
Ornaments shown on our site are personalized, as examples only, so you can see where we put the words/names you give us. Some ornaments allow you to select hair or uniform color. If there is no color choice, it is not available on that particular ornament. We will do everything possible to catch any mistakes in spelling, etc., but are not responsible if we do as you request, and it is then not correct. The ornament you see above is the way it will look when you get it, except for the personalizing instructions you give us and any optional attributes you select.
Read what our customers say about our Personalized Christmas Ornaments and their shopping experience!
11/5/2007 - "Many thanks, Debbie, again. I can't wait to see the parents' face light up when they see your ornament! I hope you and your staff realize how many people you make happy with your products! Rachel "
8/29/2013 - "My experience with OrnamentShop.com was an awesome experience. The ease of the website was great. I had no trouble finding several styles that I had never seen in stores. We received very prompt shipping and out of this world customer service. The very nice lady that customized the ornaments even called with a question on one of the items just to make sure it was right and I had not missed typed something on the web. I forgot to write her name down but want to say a huge thank you to her. You don't get that kind of customer service anymore. These are going to make my mom and grandmother very happy this Christmas. I tell all my friends about the site and plan on returning many times. Thanks again. Tracie & Dave B."
12/16/2005 - "Got the ornaments today, and LOVE them!!! I will definitely use you guys again in the future. And thanks for the speedy service!! Kathryn G."


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Stories tagged by 'parasitology'
March 09, 2012
What is an endoparasite? » Read More
November 22, 2011
What would you do if you saw tapeworm larvae cysts in your breakfast? » Read More
October 08, 2011
What did Joseph Leidy do his dinner menu featured turtles? » Read More
September 16, 2011
Has your pet had heartworm? Find out how a famous Academy scientist got to the heart of the matter of diagnosing this deadly affliction. » Read More
Dinosaurs Unearthed now through March 30, 2014
Explore Sustainability at the Academy
Members' Night at the Academy


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The CW Network To Pick Up Passions!!!!!
This petition is for the CW Network Tv to pick up the daytime soap Passions.Passions was the #1 show in daytime with the female and male audience 18-24 and it was also the #1 show on the DirecTv Channel 101.We the Passions fans want The CW Network to pick up Passions for either re-runs,new espiodes,or a spin-off.
Recent signatures
Mary Beth MouldingUnited Kingdom
4 years ago -
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The Federal Government will Become America's Model Employer for the 21st Century.
Recruit, Retain and Honor a World-Class Workforce to Serve the American People.
Find out more about Federal compensation throughout your career and around the world.
Staffing to align with your agency's mission
FSAFEDS can help you save money in 2014, but you must enroll during Open Season.
Answering your questions about Healthcare and Insurance
Congress approved a cost of living increase for Federal retirees.
Manage your retirement online.
Human Resources and Security Specialists should use this tool to determine the correct investigation level for any covered position within the U.S. Federal Government.
OPM's Human Resources Solutions organization can help your agency answer this critically important question.
Developing senior leaders in the U.S. Government through Leadership for a Democratic Society, Custom Programs and Interagency Courses.
Visit this federal site to search for our regulatory notices, proposed and final rules.
See the latest tweets on our Twitter feed, like our Facebook pages, watch our YouTube videos, and page through our Flickr photos.
Your agency can purchase a seminar several ways. How to enroll is easy! For information about registering for MDC seminars, call 304-870-8008 or email us at email@example.com. You will be directed to the Customer Service Representative who works with your agency. Tuition that is covered by a training document will be billed at the end of the course. If a purchase card is used for registration it will be processed at the time of registration.
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Your error has been logged and the appropriate people notified. You may close this message and try your command again, perhaps after refreshing the page. If you continue to experience issues, please notify the site administrator.


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Systematic (IUPAC) name | |
(6R,7R)-3-{[(aminocarbonyl)oxy]methyl}-7-{[(2Z)-2-(2-furyl)-2-(methoxyimino) acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | |
Clinical data | |
Trade names | Zinacef,TURBOCEF |
MedlinePlus | a601206 |
Pregnancy cat. | B |
Legal status | RX only |
Routes | intramuscular, intravenous, oral |
Pharmacokinetic data | |
Bioavailability | 37 percent on empty stomach, up to 52 percent if taken after food |
Half-life | 80 minutes |
Excretion | Urine 66–100 percent unchanged |
Identifiers | |
CAS number | 55268-75-2 |
ATC code | J01DC02 S01AA27 QJ51DC02 |
PubChem | CID 5361202 |
DrugBank | DB01112 |
ChemSpider | 4514699 |
ChEMBL | CHEMBL466 |
Chemical data | |
Formula | C16H16N4O8S |
Mol. mass | 424.386 g/mol |
(what is this?) (verify) |
Cefuroxime is a parenteral or oral second-generation cephalosporin antibiotic. This antibiotic was discovered by the Glaxo company, now GlaxoSmithKline, and it was first marketed in 1978 as Zinacef. Zinacef was approved by the U.S. Food and Drug Administration on Oct 19, 1983.[1] The generic form of cefuroxime is also called "Ceftin". The 17-year patent for this antibiotic has now expired in the United States, hence the patent "rights" to produce this medication are now irrelevant.
In the United States this antibiotic is also sold as "Zinacef" by Covis Pharmaceuticals.[2] In India, this antibiotic is sold as Supacef by GSK.[3]
Cefuroxime axetil is an acetoxyetyl-ester-prodrug of cefuroxime which is effective orally.[4] In Bangladesh, this drug is available as Xorimax by Sandoz, Turbocef by Beximco Pharmaceuticals Limited.
As with the other cephalosporins, although as a second-generation variety, it is less susceptible to beta-lactamase. Hence it may have greater activity against Haemophilus influenzae, Neisseria gonorrhoeae, and Lyme disease. Unlike most other second-generation cephalosporins, cefuroxime can cross the blood-brain-barrier.
Side effects[edit]
Cefuroxime is generally well-tolerated and its side effects are usually transient. If ingested after food, this antibiotic is both better absorbed and less likely to cause its most common side effects of diarrhea, nausea, vomiting, headaches/migraines, dizziness, and abdominal pain compared to most antibiotics in its class.[citation needed]
Although there is a widely-stated crossallergic risk of about 10 percent between cephalosporins and penicillin, recent assessments have shown no increased risk for a crossallergic reaction for cefuroxime and several other second-generation or later cephalosporins.[5]
- ^ "Cefuroxime medical facts from". Drugs.com.
- ^ http://www.covispharma.ch/assets/pdf/covis-pharma-acquires-portfolio-of-drugs-from-glaxosmithkline.pdf
- ^ "GlaxoSmithKline Pharmaceuticals.Prescription Medicines – Anti-Infective". Gsk-india.com. 26 March 2013.
- ^ Walter Sneader. "Drug Discovery: History".
- ^ Pichichero ME (2006). "Cephalosporins can be prescribed safely for penicillin-allergic patients" (PDF). The Journal of family practice 55 (2): 106–12. PMID 16451776.


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Quintuplets born in Czech Republic for 1st time
Sunday - 6/2/2013, 4:30pm  ET
A 23-year-old Czech woman has given birth to quintuplets for the first time in the Czech Republic.
Officials at Prague's Institute for the Care of Mother and Child say four boys -- Deniel, Michael, Alex and Martin -- and a girl -- Terezka -- were born by cesarean section on Sunday.
Zbynek Stranak, chief doctor at the neonatal section of the institute says the birth took place "without any complications."
Stranak says that Alexandra Kinova and her five babies have been placed at an intensive care unit. He says the babies who were naturally conceived have a 95-percent chance to grow up healthy.
The father was present at the birth.
Kinova who is from Milovice, a town located northeast of Prague, already had a son.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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- Musician's Friend Best Selection, Price & Service. Guaranteed.
Need Help? Ask our Experts or call 800-449-9128
Private Reserve Guitars 866-926-1923
Need Help? Ask our Experts or call 800-449-9128
There is no more powerful image in heavy metal than Slash with his signature Les Paul guitar. This 100% cotton Slash T-shirt features that famous axe as well as the Slash signature. Having powered such bands as Guns N' Roses, Snakepit, and Velvet Revolver, Slash has made his name as a metal maven.
Displaying reviews 1-3
Comments about Gear One Slash Playing Guitar T-Shirt:
This T-shirt is super great, I love it, the people around me love it... Everyone ask me where do I get it from and gets a lot of complements... It feels very very good, the perfect size, I thought they came big but it was perfect. Its really a great T-shirt I really recommend it.
Comments about Gear One Slash Playing Guitar T-Shirt:
I own two Slash shirts and every time i wear them someone comes up to me and complements me. Sometimes it leads to some conversation of music, so if you wanna look cool while supporting Slash buy this
Comments about Gear One Slash Playing Guitar T-Shirt:
Awsome period. Non stop complements
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My new Burnham Alpine gas boiler uses a variable speed blower to modulate the flame output down to 1% increments. How does it adjust the gas flow to keep the proper fuel/air mixture at all flow rates?
An old car does this with a carburetor. A new car has a mass air flow detector feeding a computer which meters the fuel injectors.
Mark Dionne
Retired software engineer
A negative pressure gas valve with a computer controlled combustion blower, just like your car with a less dense fluid.


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Winter Spare The Air Alert Ordered For Friday
The air quality district issues the wood burning ban for the fourth straight day
A Winter Spare the Air alert has been issued for Friday.
The Bay Area Air Quality Management District made the announcement at midday Thursday, saying stagnant, dry air in the region is trapping pollutants close the ground.
[Related article: Livermore Experiences Driest Year on Record]
It's the 26th alert so far this winter season. Only 10 alerts were issued during the entire winter season last year.
It's the fourth straight day an alert has been issued. A wood burning ban has been declared in 11 of the past 12 days.
"Unfortunately, weather conditions that allow smoke to build-up and cause public health impacts have not changed," said Jack Broadbent, executive officer of the air district. "Wood smoke pollution impacts us all, but it is particularly harmful to children, the elderly, and people with respiratory conditions. Winter Spare the Air Alerts help protect public health on days when air quality threatens to be unhealthy."
The Friday alert prohibits Bay Area residents from burning wood, manufactured fire logs or any other solid fuel both indoors and outdoors for 24 hours.
First-time violators of the ban are given the option of taking a wood smoke awareness class or paying a $100 fine. Second violations result in a $500 fine and the penalties rise with each violation after that.
The air quality district has 60 inspectors that follow up on complaints and issue citations.
+ Leave a Comment
Maurice Duenas
January 04, 2014 at 02:00 AM
Been burning here in Livermore almost non stop since November. My neighbors know better than to even think of fyling a complaint against me for burning in my fireplace. I will not pay PGE in there conspiracy with the air district. I will burn my firewood and no one will ever stop me.
Copyright ©2014 Planck LLC d/b/a Patch Media. All rights reserved.


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(based on 4 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Best Uses
Feels too small
Feels true to size
75% (3 reviews)
(3 reviews)
Feels too large
Feels too short
Feels true to length
Feels too long
Reviewed by 4 customers
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(1 of 1 customers found this review helpful)
Great coat, amazing price!
By Morrison1204
from Minneapolis, MN
About Me Casual Dresser
Comments about Wilsons Leather Faux-Leather Moto Jacket w/ Piping:
Great lightweight jacket for spring/early fall bike rides in the Midwest.
I just love it
By mar
from Saint Joseph Mo
very Nice******
Not as shown in the Picture
By bob
from Chicago,IL
I use it for riding my motorcycle
Great moto-style jacket
By Steveo
from MA
Nice looking moto-style jacket at a great price. Sleeves are cut a little longer in case you are on your bike. Not very heavy or insulated too much, so it's basically for casual wear, not really riding. Has a ton of pockets. Have received a lot of comments saying "cool jacket".


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Course Catalog
Spring Term online registration is now open!
Please remember to sign-in, click on the 3 Course Package tab on the left side column, then click on 3 Course Package for Spring Term in the box to the right. Add the package to your cart and then return to the course catalog to pick your classes.
Please note that OLLI no longer charges the $10.00 membership fee.
Online registration payment is with a credit card only.
To browse our available offerings, click a category on the left and then view details by clicking on the course or event listing to the right. To see the complete list of all the courses offered for this term, please click on the Classes category, below.
If you've not registered online before, you must create an account by starting at the Sign in page. Once you have created an account, you can start registering for courses and events.
If you're a new member, please let us know how you heard about OLLI for our referral program. Once you select a class or event to register for and add that item to your shopping cart, our "How did you hear about us?" selection box is found on the bottom right hand of the page!
Registration Instructions for Classes:
1. You must first sign in as a member to your account using your user name and password.
2. After signing in to your account, you may now register for the current term selecting the 3 Course Package. Once you have added this to your cart, return to the course catalog page and select each individual class you are wanting to attend. You may now also select individual events and activities, such as the fall kickoff or the fall trip, and register and pay for these while logged in to your account.
Registration Instructions for Events and Activities:
2. After signing in to your account, you may now register for the events and activites of your choice. You do not need to purchase the 3 Course Package in order to attend any of the OLLI events and activities.
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How An SEO Expert Can Improve Search Engine Rankings
Search Engine Optimization or SEO is the latest term that has been extremely popular since the last few years. This is one of the most effective and popular ways of driving a huge number of traffics to a website and improve the ranking of the site on the search engine result pages.
Written by Jennifer
If a person own a website of his/her Continue Reading...


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Copyright © 2008 Elsevier Inc. All rights reserved.
Cell Stem Cell, Volume 2, Issue 2, 118-122, 7 February 2008
Add/View Comments (0)A Critical Time for Stem Cell Research in Australia
Alan Trounson1, , and Richard P. Harvey2, 3, 4
1 Monash Immunology and Stem Cell Laboratories, Faculty of Medicine, Monash University, Clayton, Victoria, 3800, Australia
2 Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, Sydney, 2010, Australia
3 Faculty of Science, University of New South Wales, Kensington 2053, Australia
4 Faculty of Medicine, University of New South Wales, Kensington 2053, Australia
- Australia's strong historical foundation in stem cell science was boosted in 2002 by the formation of a virtual government-supported institute now called the Australian Stem Cell Centre. However, the inevitable "brain drain" and government and community expectations of quick commercial gains and rapid cures necessitate careful reconsideration of the identity and future of stem cell science in Australia.
Main Text
Stem Cell Research in Australia: A Strong Beginning
Stem cell research in Australia has been historically very strong, as exemplified by the career-long efforts of Don Metcalf and colleagues at the Walter and Eliza Hall Institute (WEHI) in Melbourne. Beginning with a simple colony-forming assay, Metcalf's exploration of colony stimulating factors (CSFs) allowed him and his colleagues to dissect relationships between hematopoietic stem cells and their differentiated progeny and the growth factor and signaling pathways that regulate the immune system in health and disease (Metcalf, 2000). Some of these cytokines, since identified and their genes cloned, have been of enormous value in medicine. Metcalf's contributions have been highly recognized (including an Albert Lasker Clinical Medical Research Award in 1993) and can be seen as the pinnacle of Australian stem cell science of the last 4 decades. One of the most significant clinical findings of this era was the demonstration that hematopoietic stem cells can be mobilized into the peripheral blood, first shown in the context of chemotherapy by Bik To and Chris Juttner at the Institute of Medical and Veterinary Science (IMVS) and Royal Adelaide Hospital in Adelaide (To et al., 1984) and then for cytokines by a team under Metcalf at WEHI/Royal Melbourne Hospital (Dührsen et al., 1988). There have been many other noteworthy Australian contributions, including an outstanding history in reproductive biology research and clinical translation culminating in the first live births using fertility drugs (Trounson et al., 1981) and in vitro fertilization (IVF) and frozen IVF embryos (Trounson and Mohr, 1983) in 1980 and 1982, respectively. Other milestones include Perry Bartlett's definition of renewable brain stem cells (WEHI) (Bartlett, 1982), the identification by Nick Gough and colleagues of leukemia inhibitory factor (LIF) (Williams et al., 1988), which maintains mouse embryonic stem (ES) cells in a pluripotent state (WEHI), and the debunking of the quantal mitosis hypothesis and skeletal muscle regeneration studies by Miranda Grounds (University of Western Australia) (Grounds and Mc Geachie, 1987).
Human Embryonic Stem Cell Research in Australia
Human embryonic stem (hES) cell research in Australia began at Monash University in Melbourne in 1994 and was championed by Martin Pera and myself (A.T.), Ben Reubinoff, and Ariff Bongso of the National University of Singapore. The pioneering work, made possible by availability of excess human embryos from the National University Singapore IVF Clinic under approval from the National Singapore Medical Ethics Committee, led to the derivation of some of the very first hES cell lines (Reubinoff et al., 2000). The studies were initially supported by in-house grant money and subsequently financed from an Australian/Singaporean investment consortium when the group founded Embryonic Stem Cell International (ESI Pty Ltd). However, the group was second to patent and publish on their isolation, thereby narrowly avoiding the controversial legal wrangling on the value of derivation patents. ESI, which has always been a Singapore-registered company, initially focused on making and distributing hES cells, with the intention of supporting (and capturing IP from) the laboratories of founding members, although it later established a clinical focus on diabetes and heart failure. The company has recently downsized in the face of its difficulties in maintaining private equity funding for an ES cell-based cell therapy program, given the regulatory issues and long lead time to product.
The most significant asset that arose in Australia from this early pioneering work was the leverage it gave to the bid for a new Australian government funding initiative that led to the formation of the Australian Stem Cell Centre (see below). In fact, the direct impact of the creation of hES cell lines in Australia (Reubinoff et al., 2000) was arguably muted because of the delay in distribution of hES lines to the wider community by companies and the ethical debate (Finkel, 2005) that immediately sprung up about their use, resulting in contested approvals by the American NIH, national and international institutional boards, and ethics committees.
More recently, in a rare conscience vote, the Australian government narrowly supported legislation allowing somatic cell nuclear transfer (SCNT) technology to proceed under strict regulation. The move followed from a review of the former legislation by a retired federal court judge, the late John Lockhart (Sinclair and Schofield, 2007), and the lead taken by the British in this area. This change gives Australia a competitive position to proceed with research aimed at the production of patient and disease-specific hES cells using the cytoplasm of oocytes or eggs excess to IVF to reprogram somatic cell nuclei. The Australian legislation on SCNT is now more consistent than that in the US, where there are different regulations depending on whether the research is government or privately funded. However, it is still illegal in Australia to produce embryos by the union of eggs and sperm specifically for research, whereas the UK, Belgium, China, Singapore, South Korea, and Sweden allow this practice. The Government Ministry of Science and Medical Research in the State of New South Wales has recently announced a new funding initiative, albeit relatively modest in terms of dollars, to support the progression of SCNT technology. Recent findings by Shinya Yamanaka at Kyoto University suggest that pluripotency can not only be understood at a biochemical and genetic level but also manipulated without the use of human embryos. Thus, community tensions over the use of excess human embryos in research evident during this period (see below) may soon ease.
The Australian Stem Cell Centre
When a group at Monash University, including myself (A.T.) and David de Kretser (a reproductive andrologist and now governor of the State of Victoria), drafted an application, which was then presented by A.T., Dianna DeVore (US patent attorney and PhD), and Robert Moses (biotechnology businessman) to the Federal Government Selection Committee and won the bid for the first Australian Biotechnology Centre of Excellence, the Australian Stem Cell Centre (ASCC) came into being. Funding came from the Australian federal government to the tune of ∼A$110 million over 10 years and was supplemented by other funds from the federal and Victorian state governments. This venture provided valuable support for a nation-wide endeavor to build strong platforms in adult and embryonic stem cell research, with a drive toward clinical therapies. The key scientists present at the onset included Paul Simmons (MSCs), Peter Rathjen (mouse ES cells), Martin Pera (human ES cells), Bernie Tuch (diabetes), Richard Harvey (adult cardiac stem cells), Mal Horne (neural stem cells), Andrew Elefanty and Ed Stanley (ES cell blood and pancreatic differentiation), Richard Boyd (thymic stem cells and regeneration), and A.T. (embryonic, placental, and pulmonary stem cells and tissue repair). This list was subsequently narrowed to a smaller group by stringent peer review of the scientific teams and an assessment of commercial potential. Although in essence a virtual institute, the ASCC has an administrative, legal, and patent node that includes some laboratories at Monash University in Melbourne and is developing a new node at the University of Queensland. The ASCC is built on a government model derivative of its history of funding Cooperative Research Centers (CRCs), involving partnerships between science and industry. The ASCC missions are to evolve an organization capable of identifying, undertaking, and supporting stem cell research and related technologies at an international level in Australia, attracting and retaining leading stem cell scientists in Australia, commercializing the outcomes of stem cell research for Australia, and engaging in advocacy and education, including training of PhDs. The ASCC is, in fact, a company (limited by guarantee) with ownership of intellectual property (IP) generated under their funding structure. The parent institutes of funded researchers and other major institutes in Australia are "stakeholders" in that they provide in kind support to the Centre and royalty-free license to background IP, albeit exclusive with respect to its commercial use. Stakeholders are built into the commercial structure of the ASCC in that commercial benefits and equity in any spin-off companies will be shared according to the proportion of contributions made in kind by an individual stakeholder. Each of the stakeholder institutes has membership on a committee that provides input into the running of the ASCC.
Without doubt, the ASCC has injected strength into stem cell research in Australia. It is likely that lasting synergies have been created between stem cell and developmental biologists, clinicians, and other scientists over a range of disciplines. One of the immediate consequences of the formation of ASCC, however, was the parochial perception by grant review committees that if work was not funded by ASCC it was not of the highest quality. At the same time, those who were granted funds by the ASCC had fewer opportunities to leverage funding from other agencies, due to the misperception that the work was adequately financed without additional support. General stem cell research now relies more on the project grant funding mechanisms of our major biomedical and biological research funding agencies, the National Health and Medical Research Council (NHMRC) and Australian Research Council (ARC), and on foundations with particular patient interests such as the Junior Diabetes Research Foundation, Multiple Sclerosis Research Societies, National Heart Foundation, and others. Research applications to these agencies must compete with all other areas of biomedical research. The growing body of scientists working on the role of stem cells in cancer may lead to additional pressures on funding demographics.
The ASCC is now in the second half of its funding cycle. With this has come a greater emphasis on commerciality in order to meet its original terms of reference: short-term commercial products and work with promise for clinical therapies in the longer term. An inevitable consequence of the commercial focus is that some of the more basic studies into stem cell biology, initially a strong component of the ASCC, now receive less support from this agency. The much hoped-for commercial success of stem cell research in Australia is not without precedent, as exemplified by the royalty stream to WEHI and the Ludwig Institute of Medical Research (Melbourne) as a result of the identification and clinical and basic science use of cytokines GM-CSF (∼$1.5 million/an) and LIF (∼$0.5 million/an). However, in relative terms, this is not a large revenue stream, considering the decades of basic research conducted by some of Australia's best immunobiologists. The likelihood of a quick return on national investments in stem cell research should be considered in this light. On the other hand, income from other discoveries in immunology (e.g., G-CSF) was lost to ill-timed patent protection, and this lesson should also be kept in mind.
The National Centre for Adult Stem Cell Research
One unusual outcome of the inevitable politicization of the debate on the ethics of human embryonic stem cell research was the awarding, without a competitive process, of a A$22 million grant by the Australian Minister of Health (strongly opposed to embryonic stem cell research) in 2006 for the establishment of the National Centre for Adult Stem Cell Research. Although the bid was based on one group's exploration of a specific class of adult stem cells, the naming of the Centre reflects the strength of partisan ethical and religious convictions in both government and the community concerning hES cell research. The Centre is headed by neurobiologist Alan Mackay-Sim and is located within the Eskitis Institute for Cell and Molecular Therapies at Griffith University in the State of Queensland. Their mission is to strengthen adult stem cell research nationally and internationally, with a view toward cell therapies for neurological conditions such as Parkinson's disease and spinal cord injury. The Centre's research focuses on olfactory neural epithelial stem cells, a readily harvestable, multipotent adult stem cell population that normally resides on the basement membrane of the olfactory epithelium, where they generate the organ's neuronal and nonneural components. Olfactory neuron ensheathing cells, which provide vital stem cell support, are also under study, and a phase I safety trial using this population in paraplegics is underway. The funding over 4 years is considered short term and does not necessarily come with the commercial expectations of the ASCC model. Its success will therefore be measured more in developed synergies and infrastructure. In this regard, it is important to note that AstraZeneca, leveraging state and federal government funds, has invested millions of dollars into natural product screening laboratories in the Eskitis Institute, which now has a bank of over 300,000 natural product samples from the Queensland rain forests and reefs as well as a growing collection of pure compounds generated by chemists in Queensland's Universities. This resource may provide unique opportunities for collaborations on drug screening using stem cells or their products as the field matures.
It is interesting to note that there are a number of other institutes in Australia that have programs dedicated to adult stem cell research. Hospital-affiliated centers, including the Victor Chang Cardiac Research Institute and Garvin Institute of Medical Research (Sydney), St. Vincent's Research Institute (Melbourne), and the Mater Medical Research Institute (Brisbane), fall under the governance and congregational leadership of the Catholic Church, which on ethical grounds does not support the destruction of human embryos for research.
There are other strong adult stem cell groups in Australia. For example, the new Queensland Brain Institute of the University of Queensland in Brisbane, headed by Perry Bartlett, has a strong commitment to adult neural stem cells, while Melissa Little, the new Chief Scientific Officer of ASCC based at the University of Queensland, oversees a program on adult kidney stem cells.
Stem Cell Brain Drain and Company Drain
Although the quality of postgraduate training in our major Australian universities is well recognized internationally, we suffer from a brain drain toward strong scientific centers in the US and Europe. This effect is enhanced by an attitude among emerging scientists, encouraged by their mentors, that some years spent in postdoctoral positions overseas is largely essential for career progression at home. Many expatriates return, but it is inevitable that we will lose some of our best permanently, or at least for their most creative and influential years. Two of our most accomplished senior stem cell scientists and founding members of the ASCC, Paul Simmons and Martin Pera, have recently left Australia to take up directorships of stem cell institutes in the US. In addition, one of us (A.T.) has recently assumed the presidency of the California Institute of Regenerative Medicine, which over the coming years will distribute some $3 billion of Californian public money to pluripotential stem cell research. Government efforts are in place to stem the brain drain at both postdoctoral and elite levels by offering attractive fellowship schemes. However, stem cell research has not yet reached its crescendo, and the massive amount of support available overseas may simply overwhelm our relatively modest local fellowship and stem cell funding initiatives. This pattern will continue to be a major issue as we attempt to keep pace with global developments in stem cell science.
There has also been a noticeable exodus of stem cell companies, causing an additional blow to our strategic advantage. As noted, ESI was registered in Singapore from the beginning. BresaGen and Stem Cell Sciences, both involved in ES cell research, have moved most of their activities offshore. Stem Cell Sciences, founded by Australian Peter Mountford, is listed dually in the UK and Australia and retains offices and laboratories in Melbourne working on embryonic stem cell derivatives for drug discovery. However, their major scientific and fundraising activities are within the UK. Perhaps the main reason for this divide is that the market size in Australia, with a population of 20.5 million, is ultimately small, and the best value for shareholders is for companies to position themselves to register products in the major population centers of the Western World. However, Australia currently provides a regulatory environment conducive to performing early phase safety and proof-of-principle clinical trials. This is due to the fact that such trials can be initiated directly via a principal investigator to a registered ethics committee for approval, without the necessity of directly engaging Australia's government regulatory agency for medical drugs and devices (FDA equivalent), the Therapeutic Goods Administration (TGA). This approach is not possible in the US and Europe, which also have greater expertise and expectations for conducting the more demanding phase II and III trials. The TGA is guided largely by the FDA with respect to the regulatory benchmarks required for these latter trials to proceed. However, the environment for early trials, combined with a less complex pre- and early listing fundraising environment, may see the number of companies in Australia grow and thrive as our science matures. The stem cell therapeutics company Mesoblast is noteworthy this regard. Founded in Melbourne by expatriate Australian Sylviu Itescu, it focuses on developing bone marrow mesenchymal progenitor cell (MPC) therapies for bone, cartilage, and cardiovascular repair. Listed in 2004, Mesoblast has acquired a stake in Angioblast, its US parent company that owns the composition of matter patents for MPC isolation and growth developed by Paul Simmons, Andrew Zannettino, and Stan Gronthos at the Hanson Institute and Institute of Medical and Veterinary Science in Adelaide. Two small phase I trials have been conducted for chronic angina and nonunion fractures in Australia with phase II trials underway in the US. Cell therapies using endogenous cells such as MPCs may reach the market long before those involving hES cell derivatives, due to regulatory and safety issues. However, the competition is fierce, with a major player in the MPC world, Osaris Therapeutics, holding over 150 patents, including one for the use of MPCs in unrelated MHC-mismatched donors, the key patent covering the universal stem cell donor concept.
Current State of Stem Cell Research in Australia
Stem cell research continues to grow in Australia. The breadth and number of the Australian research reports (178) presented at the International Society for Stem Cell Research meeting held in June 2007, in Cairns, Queensland, presided over by (now expatriate) Australian Paul Simmons as society president, is indicative of the healthy state of the research and of the variety of funds supporting the work. A recent highlight was the demonstration by Jane Visvader and Geoff Lindeman at WEHI that a complete mammary gland could be generated from a single stem cell (Shackleton et al., 2006). This is the first demonstration of a single cell being able to reconstitute a solid organ and provides a strong platform for understanding the lineage hierarchy in breast development and the cellular origins of breast cancer. There are a number of groups active in directed differentiation of human and mouse ES cells, including Gail Risbridger and colleagues at Monash Institute of Medical Research and Monash Immunology and Stem Cell Laboratories (MISCL) who recently exploited rodent urogenital mesenchyme as an inductive source to produce prostate tissue from hES cells (Taylor et al., 2006). A team led by Andrew Elefanty and Ed Stanley at MISCL is exploring blood and pancreatic differentiation from human ES cells. Richard Boyd, A.T., Claude Bernard, and Ban Hoc Toh at MISCL are using an innovative stem cell approach to study the induction of tolerance for delivery of ES cell progeny and the reversal of autoimmune diseases.
Another important development in stem cell research in Australia is on the horizon. The Department of Health and Aging, the Victorian state government, and Monash University have jointly invested A$153 million to establish the Australian Regenerative Medicine Institute, which is committed to unraveling basic cellular and molecular mechanisms underlying regenerative process in vital organs damaged by disease, injury, or genetic conditions. With laboratories to open in 2008, the new institute is directed by Nadia Rosenthal, a US-born muscle regeneration biologist, who is currently Head of the European Molecular Biology Laboratory (EMBL) outstation in Monterotondo near Rome.
More recently, the Australian Government Department of Education Science and Training and the government of China have awarded the Australia-China Centre of Excellence in Stem Cell Sciences to the Stem Cell Research Centre at the University of Peking and MISCL at Monash University. This is a significant regional linkage supported by both governments that builds on the reputations and contributions of these two research teams to establish a very significant body of stem cell scientists. The teams are to be headed by Richard Boyd and Graham Jenkin (MISCL) and Lingsong Li (Peking University).
It is clear that both adult and ES cell research are surging forward and that the initial support provided by the Australian government will need to be supplemented by other public and philanthropic institutions, industry investment capital, as well as the usual sources from the NHMRC and ARC in the future if this expansion of activity and international competitiveness is to be sustained.
Retaining a Strong Australian Stem Cell Research Environment
Retaining our leading Australian scientists will require more than the provision of sufficient research funding, traineeships for young scientists, further major facilities, and state-of-the-art equipment. In addition, a regulatory environment that enables researchers to compete internationally and support for linkages to international collaborations are both necessary for Australia to remain a significant part of the medical revolution in stem cell therapies. However, the very competitive Australian research environment will almost certainly limit funding of this research. Indeed, it is increasingly apparent that innovative approaches for support of stem cell research, such as that designed in California utilizing bond assets, international linkages, and the cofunding of research by public and private institutions will be necessary to deliver the clinical benefits of stem cell therapies to patients in Australia. There are well-defined pathways for these avenues to be developed, and Australia should engage in regional partnerships and international agreements to remain competitive. It would be wise to encourage the involvement of those who have recently left for overseas to help facilitate these arrangements.
The evolution of strong, independent stem cell basic research and translational centers in Australia is important. One hopes this will happen with a variety of strategies and niche interests and that free exchange of scientific information, and community education and involvement in the variety of approaches necessary, will accompany this expansion. It is also hoped that more Australian universities, working with local governments, will commit to building regenerative medicine institutes of international caliber.
Lessons for Other Stem Cell Initiatives?
The confidence demonstrated by the Australian government in forming the ASCC and backing scientists in this new and innovative area of research is laudable, and the very positive international response to the promise of stem cell therapies highlights the wisdom of this decision.
However, much rests on the shoulders of the ASCC and other emerging stem cell organizations. Under the ASCC, Australian stem cell researchers were provided a unique impetus to galvanize and collaboratively perform in a range of commercial and basic science endeavors at levels rarely achieved before. There have been the inevitable teething problems and lessons learned in building and running a high-profile virtual institute with this breadth of mission. Specific challenges included establishing a common sense of identity, stable management, transparent peer review processes, good communication, and synergies between geographically isolated groups. The loss of some of our best stem cell researchers to greener pastures overseas highlights an ongoing danger: without the right sort of support for key scientific leaders and to build a strong culture of stem cell research from bench to clinic, a futile cycle will develop in which investment in current personnel and the training of future leaders will be lost to other interests.
Within the ASCC, funds are now being focused on a research process in which discoveries can be rapidly converted to commercial products. With this as Australia's premier stem cell initiative, and arguably the only one with direct links to government, there are risks that high-value basic science will suffer and that appointments and allocations will no longer reflect acknowledged scientific leadership. Whether this commercial model proves to be a prudent investment for Australian science and technology remains to be seen. In considering current versus future commercial opportunities, some key issues are the relative immaturity of most areas of the stem cell field and the vigor with which clinicians worldwide have embraced cell therapy clinical trials, despite limited (and possibly misguided) information as to biological mechanisms. Also, we are in the midst of a revolution in our understanding of the basic aspects of cell potency and tissue homeostasis, repair, and regeneration. Because it is highly likely that creative basic science endeavors in these areas will form the germ of future commercialization opportunities in this fast-moving field, it is of some concern that key strengths of Australian stem cell biology and technology are not currently being targeted for support. There is much ahead of us, and Australia needs to build a very broad foundation in order to reap the rewards of the future.
The relative emphasis placed on basic and commercial research requires constant review and informed debate. It is an equation that can shift depending on community expectations and the lobbying of politicians, patients, and scientists alike. On this point, most public education has thus far focused on the ethics and promise of stem cell research. However, it will also be necessary to instill into the public mind a realistic understanding of how science progresses and to establish a credible timescale for health outcomes arising from the stem cell biomedical revolution. This is an achievable challenge, given the general heightened public awareness of stem cells, a positive and receptive public attitude toward investment in scientific and medical research, and what we perceive to be a developing sophistication in reportage of science by the media. Stem cell institutes and scientists should continue to be proactive in community and media education.
In summary, greater investment is needed by the Australian government and by national and international commercial sectors in research and development across the broad spectrum of stem cell initiatives in Australia in order to maintain our research competitiveness. This message is equally applicable to other nations with emerging stem cell initiatives. This is an important time in the history of biomedical research. The issue for reflection is not whether we can afford to fund stem cell research, but whether we can afford not to.
The Victor Chang Cardiac Research Institute does not engage in, nor does it condone, the destruction of human embryos for research.
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