text:
Study to Calculate the Radiation Dosimetry in Subjects With Head and Neck Cancer
- Full Text View
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- How to Read a Study Record
Preliminary observations suggest positron emission tomography (PET) imaging with an F-18 labeled thymidine analog (FLT) can selectively identify proliferating and non-proliferating tissues, including tumors. FLT uptake in the tumor appears to reflect the level of cells undergoing DNA synthesis. This is clinically important because cell proliferation markers have significant prognostic value, both prior to initiating radiotherapy and as they change during the course of therapy. In the proposed study, the researchers assess the biodistribution and radiation dosimetry of FLT to obtain the necessary data to file an Investigational New Drug (IND) application with the Food and Drug Administration (FDA). The information collected under Radioactive Drug Research Committee (RDRC) approval will not be used for diagnostic purposes, to assess the subject's response to therapy, or for clinical management of the subject.
Condition | Intervention | Phase |
Head and Neck Cancer |
Procedure: F-18 Fluorothymidine |
Phase 1 |
Study Type: | Observational |
Study Design: | Observational Model: Cohort Time Perspective: Prospective |
Official Title: | Biodistribution and Radiation Dosimetry of F-18 Fluorothymidine (FLT) Imaged With Positron Emission Tomography (PET) in Patients With Head and Neck Cancer: A Radioactive Drug Research Committee (RDRC) Study |
Tumor biopsy, blood samples
Enrollment: | 9 |
Study Start Date: | October 2005 |
Study Completion Date: | April 2008 |
Groups/Cohorts | Assigned Interventions |
Study group receiving FLT for imaging
Procedure: F-18 Fluorothymidine |
Detailed Description:
There are approximately 40,000 new cases of head and neck cancer each year in the United States. Worldwide more than 500,000 individuals will develop head and neck cancer each year, ranking as the sixth most common cancer. These cancers are predominately squamous cell cancers. Approximately two thirds of subjects will present with locally advanced disease with either large disease at the primary site and/or spread to regional lymph node levels.
Despite aggressive treatment, 5-year survival remains poor (overall, approximately 50%). The major site of treatment failure is within the head and neck region, with distant metastases occurring in approximately 25% of subjects and usually after local and/or regional (nodal) failure.
Current treatment options for locally advanced head and neck cancer include combinations of surgery, radiation therapy, and chemotherapy. It is currently difficult to predict which combination will be best suited for any particular individual. Rapid methods of assessing the response of subjects to chemo-radiotherapy would be a useful tool, as it would permit the oncologist to change therapies, either in type or degree, in cases when the subject does not respond to the initial therapy regimen. Current best methods of evaluating tumor response are either serial CT examinations, so that changes in tumor size can be estimated or a fluorodeoxyglucose (FDG) positron emission tomography (PET) study in which changes in the metabolic status of the tumor are evaluated. Unfortunately, the anatomic information afforded by CT examinations often require months after treatment to allow the full effects of therapy to take place. Even after this time, the metabolic activity of any remaining tissue is nearly impossible to assess by CT scan, making it difficult to distinguish between fibrosis and viable tissue. Generally the FDG studies require 3-4 weeks after the end of the therapeutic regime before the relevant information is available, with more reliable information obtained at 3-4 months after treatment.
It is predictable that the most immediate signal of an anti-tumor therapeutic regime that has been successful is that the tumor cells will stop dividing (proliferating) after the therapy is initiated. Therefore, a tracer which is taken up into and retained in cells as a function of their proliferative activity should provide rapid information as to the effectiveness of the treatment. It is the objective of this study to determine the biodistribution and radiation dosimetry of tracer F-18 3`-deoxy-3`-fluorothymidine. This distribution data is essential before an Investigational New Drug (IND) application can be filed with the FDA that would allow the use of this tracer in clinical trials.
Ages Eligible for Study: | 21 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Head & Neck Cancer
Inclusion Criteria:
- Ability to understand and willingness to sign a written informed consent document.
- Subject must have histologically confirmed stage III, or IV squamous cell carcinoma of the head and neck whose primary origin was from the oral cavity, oropharynx, hypopharynx, or larynx. Carcinoma must be staged using the American Joint Committee on Cancer (AJCC) staging criteria version 6. Adequate tumor must be amenable to biopsy via outpatient methods, therefore the majority of subjects will be those with oropharyngeal lesions.
- Subjects must be scheduled to receive combined chemo-radiotherapy treatment for their standard cancer care. Treatment decisions will be made by the treating otolaryngologist, radiation, and medical oncologists.
- Males or females greater than or equal to 21 years of age. Squamous cell cancer of the head and neck is exceedingly rare in children and not generally applicable to the pediatric population.
- Karnofsky score greater than or equal to 60% at time of screening.
- Life expectancy of greater than 6 months.
Subject must have normal organ and marrow function as defined below:
- leukocytes greater than or equal to 3,000/microL
- absolute neutrophil count greater than or equal to 1,500/microL
- platelets greater than or equal to 100,000/microL
- total bilirubin within normal institutional limits
- AST(SGOT)/ALT(SGPT) less than or equal to 2.5 X institutional upper limit of normal
- creatinine within normal institutional limits
- BUN within normal institutional limits
- PT and PTT < 2.0 X upper normal limits
- The effects of FLT on the developing human fetus are unknown. For this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately. A screening urine hCG will be administered to women of childbearing potential before each FLT scan.
Exclusion Criteria:
- Subjects who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier.
- Subject may not be receiving any other investigational agents.
- Subject with a Karnofsky score below 60.
- Pregnant women are excluded from this study. FLT PET has the potential for teratogenic effects. Because there are potentially unknown risks for adverse events in nursing infants secondary to treatment of the mother with FLT, breastfeeding should be discontinued if the mother is imaged with FLT and may not resume for 48 hours after the FLT imaging.
- Subject with an inadequate marrow reserve as determined by history and/or the above tests.
- Subject with a bleeding or clotting dysfunction as determined by medical history and above tests.
- Subjects taking nucleoside analog medications such as those used as antiretroviral agents.
- Inadequate tumor volume to allow for 2 biopsies.
United States, Iowa | |
University of Iowa Hospitals and Clinics | |
Iowa City, Iowa, United States, 52242 |
Principal Investigator: | Yusuf Menda, MD | University of Iowa, Department of Radiology-Nuclear Medicine | |
Principal Investigator: | Kenneth J Dornfeld, MD, PhD | University of Iowa | |
Principal Investigator: | Timothy Tewson, PhD | University of Iowa, Department of Radiology-Nuclear Medicine |
No publications provided
Responsible Party: | Yusuf Menda, M.D., University of Iowa Hospitals & Clinics |
ClinicalTrials.gov Identifier: | NCT00245349 History of Changes |
Other Study ID Numbers: | 200502799 |
Study First Received: | October 25, 2005 |
Last Updated: | June 9, 2008 |
Health Authority: | United States: Institutional Review Board |
Keywords provided by University of Iowa:
Head and Neck cancer Squamous cell carcinoma FLT Fluorothymidine F-18 |
Additional relevant MeSH terms:
Head and Neck Neoplasms Neoplasms by Site Neoplasms |
ClinicalTrials.gov processed this record on March 09, 2014


text:
Chelsea Lately
Chelsea Lately | |
Genre | Talk show |
Written by |
Directed by | Jim Yukich |
Starring | Chelsea Handler |
Narrated by | Mike Rock |
Country of origin | United States |
Original language(s) | English |
No. of seasons | 7 |
No. of episodes | 1048 |
Production | |
Executive producer(s) |
Producer(s) |
Camera setup | Multiple |
Running time | 22 to 24 minutes |
Production company(s) | Borderline Amazing Productions |
Broadcast | |
Original channel | E! |
Picture format | 480i (16:9 SDTV) 1080i (HDTV) |
Original run | July 16, 2007 | – present
Chronology | |
Preceded by | The Chelsea Handler Show |
Related shows | After Lately |
External links | |
Website |
Chelsea Lately is an American late night comedy talk show hosted by comedian Chelsea Handler on E!. The show debuted on July 16, 2007, and is produced by Handler's production company, Borderline Amazing Productions. It is taped at Universal Studios Stage 1 in Universal City, California.[1] In American markets, the show airs at 11:00 p.m. Eastern and 8:00 p.m. Pacific time[2] but is recorded at 3:30 p.m. PT, usually the same day. Chelsea Lately carries a TV-14 rating due to explicit language, strong sexual situations and suggestive references.[3]
On November 15, 2011, it was announced that the show's run has been extended through 2014.[4]
The series has one spin-off, After Lately, a behind-the-scenes mockumentary, which premiered on March 6, 2011.
Handler was approached to host her own late night talk show while she was going out with the head of Comcast (E!'s parent company),[5] but stated she was skeptical of the idea of her own show.[6] Chelsea Lately premiered on July 17, 2007, at 11:30 p.m.
Chelsea Lately has been renewed through 2014.[7]
On October 15, 2012, Chelsea Lately relocated from the Westside Media Center Studios in West Los Angeles, a facility formerly used by E! sister network G4 to record Attack of the Show and whose set was adapted to Chelsea Lately with only background changes and the addition of audience seating, to a completely new set in Stage 1 at Universal Studios Hollywood, which had been used by The Tonight Show with Conan O'Brien during its short seven-month run.[8] When the series moved to a new studio, the opening theme was changed to a new version composed by Pharrell.
Episode format[edit]
Chelsea Lately is presented in a half-hour format, and is broadcast Monday through Friday at 11:00 p.m ET/PT, although the Friday show is frequently a re-run. Chelsea Lately opens cold and Handler performs a short stand-up monologue. The routine is usually focused on a topic from pop culture or current events, and may include a video clip or other visual aid. Over the opening credits, the announcer presents the topics of discussion and the show's guest, then makes a comment about something totally irrelevant.
After the open, Handler will introduce the round table panel of three guests consisting of some combination of comedians, actors, or staff members. She lastly introduces the show regular, her assistant Chuy Bravo (born Jesus Melgoza)[9] who sits in his own chair near the edge of the studio's stage. Handler then discusses the goings on in pop culture with the round table members, occasionally including Chuy whose comments are always one-liner jokes. After the round table ends, if there is a sketch in the episode, it plays next. Then, after returning from a commercial break, Handler interviews a celebrity guest (or guests) for about six minutes each show. The show then closes with either another very short monologue (essentially Handler delivering a one-liner) or with a small segment like "Fat Baby" with pictures shown for comedic value. Handler and her sidekick Chuy then usually interact with the audience as the closing credits and music plays.
Handler's "assistant", Chuy Bravo, along with sitting across from the round table, often participates alongside Handler in video segments for the show.
- Round table regulars
- Bill Bellamy
- Matt Braunger
- Kurt Braunohler
- John Caparulo
- Sarah Colonna
- Lavell Crawford
- Whitney Cummings
- Thomas Dale
- Dov Davidoff
- James Davis
- Cameron Esposito
- Fortune Feimster
- Greg Fitzsimmons
- Chris Franjola
- Ben Gleib
- Chris Hardwick
- Ian Karmel
- Moshe Kasher
- Kerri Kenney-Silver
- Jen Kirkman
- Jo Koy
- Annie Lederman
- Bobby Lee
- Natasha Leggero
- Dan Levy
- Loni Love
- Mo Mandel
- Ross Mathews
- Dan Maurio
- Julian McCullough
- Heather McDonald
- T. J. Miller
- Arden Myrin
- Greg Proops
- Mary Lynn Rajskub
- April Richardson
- Nico Santos
- Brody Stevens
- Ryan Stout
- Claire Titelman
- Gary Valentine
- Jeff Wild
- Josh Wolf
- Brad Wollack
- Michael Yo
- Wildlife Segments
Chelsea Lately features special wildlife segments three to four times a year on average – in 2013, New York Times best-selling author, naturalist and former paratrooper, Bradley Trevor Greive, assumed the hazardous role of Chelsea Lately's resident wildlife expert. [10]
From 2012 to 2013, viewership decreased from 613,000 to 571,000.[11]
As of 2011[update], Chelsea Lately averaged 960,000 viewers per episode[12] and attracts more women aged 18 to 34 than The Late Late Show with Craig Ferguson and Last Call with Carson Daly.[13]
As of October 2011[update], the highest-rated episode of Chelsea Lately garnered 1.8 million viewers: this was the October 10, 2011, episode hosted by Ross Mathews featuring Kendra and Hank Baskett, following the Kardashian wedding special.[14]
It was announced on August 6, 2013, that Lindsay Lohan's guest host appearance on Chelsea Lately became the most watched episode since October 2012 by acquiring 890,000 total viewers.[15]
For January—October 2013, Chelsea Lately attracted $30.3 million in advertising for an audience whose median age was 42.8.[11]
Guest hosts[edit]
Due to sickness, injury or holidays, Handler has been unable to host some episodes, calling for guest hosts to stand in. In the past, frequent "round table" panelists Ross Mathews, Josh Wolf and Fortune Feimster have guest-hosted, with Mathews receiving very positive reviews.[16]
Since July 2012, there have been several celebrity guest hosts during various episodes:
- Comedian/actor Wanda Sykes guest-hosted on July 30, 2012, while Handler was in London.
- Comedic actor Kevin Hart guest-hosted on July 31 and August 1, 2012, while Handler was in London.
- Actor/comedian Dax Shepard guest-hosted on August 2, 2012, while Handler was in London.[17]
- Australian comedic actor Rebel Wilson guest-hosted on September 7, 2012. Wilson's time as guest host was not due to Handler's unavailability to shoot the episode, but rather at Wilson's request to host. Handler reversed her role and was the celebrity guest interviewed by Wilson on this episode.
- As part of the show's "Celebrity Guest Host Week", the first week of December 2012 had episodes guest-hosted by television personality Amanda De Cadenet, actress/singer Kristin Chenoweth, comedic actress Casey Wilson, and musician Dave Grohl.[18]
- In February 2013, Grohl returned to host for a week that included an interview with Elton John.[19]
- The three Kardashian sisters, Kourtney, Kim, and Khloé, and their mother Kris Jenner guest hosted on April 8, 2013. This was a planned event, though it's unclear if it was arranged by Handler and the Kardashians or by the mother network where they all work.[20]
- Actress Lindsay Lohan guest-hosted on August 5, 2013, only 6 days after being released from her court-ordered 90-day incarceration period.
Specials and spin-offs[edit]
After Lately[edit]
After Lately is a semi-scripted parody of a reality show (in the vein of shows such as The Larry Sanders Show and Curb Your Enthusiasm) in which the various cast members, writers, crew, and even 'hangers-on' of Chelsea Lately are shown bickering and arguing over mostly trivial and petty matters, and competing for show air time and personal approval from Chelsea. Handler herself usually appears in very few scenes of the program and is always portrayed as having open and utter disdain for everyone beneath her. The series premiered on March 6, 2011, and consisted of eight episodes.[21] After Lately was renewed for a second season on May 5, 2011,[22] and for a third season on April 27, 2012.[23]
Comedians of Chelsea Lately[edit]
A special titled Comedians of Chelsea Lately premiered on August 14, 2009 and lasted four weeks. The special consisted of Chelsea Lately round-table regulars such as Loni Love, Jo Koy, and others performing their comedy standup routines. The standup routines lasted for about 6 to 9 minutes in length. The first airing of the special had round-table regulars Guy Branum, Sarah Colonna, and Chris Franjola performing.
Chelsea Lately Bloopers[edit]
A Chelsea Lately special entitled Chelsea Lately Bloopers aired on December 22, 2009. It featured new bloopers, deleted scenes, and outtakes from the round table and guest interviews.
During the June 20, 2011, episode, while discussing Amy Winehouse's poorly received performance at a concert in Belgrade, Handler read a statement by Serbian Defense Minister Dragan Šutanovac calling Winehouse's performance a "shame and a disappointment". Handler then stated, "Well, so is your country".[24] The comment has since drawn criticism, with requests for Handler to apologize for the comment. A Facebook page and change.org petition have also been created calling for a boycott of Handler and E! until a public apology is given. Handler has yet to officially comment on the matter, but has on a number of occasions acknowledged on the show that she is no longer well received there.[24]
On June 25, 2011, Serbian Ambassador to the United States Vladimir Petrović sent a letter to Bonnie Hammer, president of NBCUniversal Cable (which oversees the E! network), describing Handler's act as "inappropriate, distasteful, and just plain bad humor".[25]
According to an E! rep, a false request was reported in January 2013 claiming Comcast (which owns NBC and E!) warned Handler and the show's staff not to make any more jokes about the Today hosts.[26]
Year | Result | Award | Category |
2009 | Winner | Teen Choice Award | Choice Late-Night Talk Show |
2010 | Nominated | People's Choice Awards | TV Talk Show |
See also[edit]
- ^ "Chelsea Lately Taping Tickets". On Camera Audiences. Retrieved August 2, 2008.
- ^ Pazmino, Gloria (January 28, 2009). "'Chelsea Lately' Gets New 11:00 P.M. Slot". broadcastingcable.com. Retrieved June 9, 2010.
- ^ Kugel, Allison (February 20, 2008). "Chelsea Handler Pulls No Punches with PR.com". pr.com. Retrieved June 10, 2010.
- ^ Andreeva, Nellie. "Chelsea Handler Signs Big New E! Deal". Deadline.com. Retrieved October 19, 2012.
- ^ Goldman, Andrew (September 16, 2011). "There Is No Escaping Whitney Cummings". The New York Times.
- ^ Karpel, Ari (July 11, 2008). "Too hot to Handler". ew.com.
- ^ Gorman, Bill (November 15, 2011). "'Chelsea Lately' Renewed Through 2014 By E!". TV by the Numbers (Press release).
- ^ "E!'s Hit Late-Night Series 'Chelsea Lately' Relocates to the Historic Stage 1 at Universal Studios Beginning October 15". TV By the Numbers. Retrieved September 27, 2012.
- ^ [1][dead link]
- ^ "IMDB Bradley Trevor Greive".
- ^ a b Poggi, Jeanine (February 13, 2014). "Why Jimmy Fallon's 'Tonight Show' Can Thrive With Fewer Viewers When Conan's Couldn't". Advertising Age. Retrieved 2014-02-14.
- ^ Baldwin, Kristen (2011-06-30). "'Chelsea Lately' tops 'Conan' in ratings. What's she doing right? | PopWatch | EW.com". Popwatch.ew.com. Retrieved 2014-02-23.
- ^ Hibberd, James (March 23, 2009). "Chelsea Handler inks new deal at Comcast". hollywoodreporter.com.
- ^ "E! Scores Most-Watched Event Ever With "Kim's Fairytale Wedding: A Kardashian Event" Drawing 10.5 Million Total Viewers Across Two-Part Event – Ratings | TVbytheNumbers". Tvbythenumbers.zap2it.com. Retrieved October 19, 2012.
- ^ Bibel, Sara (August 6, 2013). "Lindsay Lohan's Guest Host Appearance on E!'s 'Chelsea Lately' is Most Watched Episode Since October 2012". TV by the Numbers (Press release).
- ^ Gunjan. "Comedian". Fortune Feimster. Retrieved October 19, 2012.
- ^ "Chelsea Lately Episodes – Chelsea Lately Season 6 2012 Episode Guides – Watch Chelsea Lately Episodes from E!". TVGuide.com. Retrieved October 19, 2012.
- ^ Stecker, Joshua. "Foo Fighters' Dave Grohl Hosts 'Chelsea Lately' Thursday". The Hollywood Reporter.
- ^ [2][dead link]
- ^ Hughes, Jason. "The Kardashians Take Over 'Chelsea Lately'". Huffington Post.
- ^ "Shows A-Z | TheFutonCritic.com – The Web's Best Television Resource". TheFutonCritic.com. Retrieved October 19, 2012.
- ^ Andreeva, Nellie. "E! Renews 'After Lately' For Second Season". Deadline.com. Retrieved October 19, 2012.
- ^ Andreeva, Nellie. "'After Lately' Renewed For Season 3 By E!". Deadline.com. Retrieved October 19, 2012.
- ^ a b Amter, Charlie (June 23, 2001). "Chelsea Handler in Hot Water With Serbians Over Remarks". hollywoodreporter.com. Retrieved June 25, 2011.
- ^ "Ambassador Petrovic Letter to Chelsea Lately Show". usaserbs.net. Retrieved June 26, 2011.
- ^ "Handler rubbing Lauer's nose in it". Page Six. January 17, 2013.
External links[edit]
- 2000s American television series
- 2010s American television series
- 2007 American television series debuts
- American comedy television series
- American late-night television programs
- American variety television series
- E! network shows
- English-language television programming
- Satirical television programmes
- Participants in American reality television series

subset: commoncrawl


text:
The Office of the Internal Auditor will deliver the highest quality service to assist the Kentucky State University Board of Regents, administration, staff and faculty in the achievement of the university's goals and objectives.
The philosophy of the Office of the Internal Auditor is to assist the university in managing risks, including financial, operational and other business risks by measuring and evaluating the effectiveness and efficiency of financial, managerial and operational controls and by recommending enhancements or corrective actions. Empowerment is the key. At the same time, accountability, integrity, responsibility and sound business practices are essential to success.


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text:
Modified Vaccinia Ankara (MVA) Vaccine Study
This study has been completed.
Chinese University of Hong Kong
Information provided by (Responsible Party):
CCTU, Chinese University of Hong Kong
ClinicalTrials.gov Identifier:
First received: December 8, 2010
Last updated: December 21, 2011
Last verified: December 2011
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This is a phase I, dose escalation trial of MVA-EBNA1/LMP2 vaccine across a pre-defined range of doses in patients in remission having had an EBV+ nasopharyngeal carcinoma (NPC).
Condition | Intervention | Phase |
Nasopharyngeal Neoplasms Epstein-Barr Virus Infections |
Drug: MVA Vaccine |
Phase 1 |
Study Type: | Interventional |
Study Design: | Endpoint Classification: Safety/Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | A Phase I, Dose Escalation Trial of Recombinant Modified Vaccinia Ankara (MVA)-Based Vaccine Encoding Epstein-Barr Virus Target Antigens |
Resource links provided by NLM:
Further study details as provided by Chinese University of Hong Kong:
Primary Outcome Measures:
- To determine safety and to characterise the toxicity profile of MVA-EBNA1/LMP2 vaccine [ Time Frame: 4 years ] [ Designated as safety issue: Yes ]
Secondary Outcome Measures:
- To describe changes in the frequency of functional T-cell responses to MHC class I and II-restricted epitopes within EBNA1 and LMP2 in peripheral blood at sequential time-points before, during and up to nine months after the vaccination course. [ Time Frame: 4 years ] [ Designated as safety issue: No ]
- To assess changes in levels of EBV genome levels in plasma [ Time Frame: 4 Years ] [ Designated as safety issue: No ]
Enrollment: | 18 |
Study Start Date: | September 2006 |
Study Completion Date: | September 2010 |
Primary Completion Date: | September 2010 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: MVA Vaccine |
Drug: MVA Vaccine
The starting dose will be 5 x 107 plaque forming units (pfu) given by intradermal vaccination. Cohorts of three patients will receive escalating doses of the vaccine (100%, 100%, 67% and 50%). The dose escalation scheme is 5 x 107 pfu, 1 x 108 pfu, 2 x 108 pfu, 3.3 x 108 pfu, 5 x 108pfu. This will be dependant on toxicity.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Histologically confirmed NPC, in which the presence of EBV within the malignant cells has been demonstrated by (1) EBER (EBV early RNA) in situ hybridisation in more than 50% of the malignant cells, or (2) undifferentiated or poorly differentiated carcinoma histology in association with a raised serum titer of IgA to EBV VCA.
- Patients in remission from disease, ie complete response (CR) or unconfirmed complete response (CRu).
- Completion of standard therapy for malignancy at least 12 weeks before trial entry.
- Written informed consent and the ability of the patient to co-operate with treatment and follow up must be ensured and documented.
- Age greater than 18 years.
- World Health Organisation (WHO) performance status of 0 or 1
- Life expectancy of at least 4 months.
Haematological and biochemical indices (these measurements must be performed within 28 days prior to the patient going on study):
- Haemoglobin (Hb) > 10.0 g/dl
- Lymphocytes > 1.0 x 109/L (or above the lower limit of normal range of institutional laboratory)
- Neutrophils ≥ 1.5 x 109/L
- Platelets (Plts) ≥ 100 x 109/L
- baseline liver function tests :
- Serum bilirubin ≤ 1.5 x upper normal limit
- Serum alkaline phosphatase, alanine amino-transferase (ALT) and/or aspartate amino-transferase (AST) < 1.5 x ULN.
- baseline renal function test:
- calculated creatinine clearance > 50ml/min Female patients of child-bearing potential are eligible, provided they have a negative pregnancy test prior to enrolment and agree to use appropriate medically approved contraception during the study up to six months after the last vaccination.
- Male patients must agree to use appropriate medically approved contraception during the study up to six months after the last vaccination.
Exclusion Criteria:
- Receiving current chemotherapy or radiotherapy, or received within 12 weeks of trial entry.
- Known chronic active infection with Hepatitis B, Hepatitis C or Human Immunodeficiency Virus (HIV).
- Current active autoimmune disease.
- Current active skin diseases requiring therapy (psoriasis, eczema etc).
- Ongoing active infection.
- History of anaphylaxis or severe allergy to vaccination.
- Allergy to eggs or egg products.
- Previous myeloablative therapy followed by an autologous or allogeneic haematopoietic stem cell transplant.
- Patients who have had a splenectomy or splenic irradiation, or with known splenic dysfunction.
- Receiving current immunosuppressive medication, including corticosteroids.
- Pregnant and lactating women.
- Ongoing toxic manifestations of previous treatment. Exceptions to this are alopecia or certain Grade 1 toxicities which in the opinion of the Investigator and Cancer Research UK should not exclude the patient.
- Major thoracic and/or abdominal surgery in the preceding four weeks from which the patient has not yet recovered.
- Patients with any other condition which in the Investigator's opinion would not make the patient a good candidate for the clinical trial.
- Concurrent congestive heart failure or prior history of class III/ IV cardiac disease
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01256853
Hong Kong | |
Department of Clinical Oncology, Prince of Wales Hospital | |
Hong Kong, Hong Kong |
Sponsors and Collaborators
Chinese University of Hong Kong
Principal Investigator: | Anthony TC Chan, MD, FRCP | Department of Clinical Oncology, The Chinese University of Hong Kong |
More Information
No publications provided
Keywords provided by Chinese University of Hong Kong:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 10, 2014
No publications provided
Responsible Party: | CCTU, Comprehensive Clinical Trial Unit, Chinese University of Hong Kong |
ClinicalTrials.gov Identifier: | NCT01256853 History of Changes |
Other Study ID Numbers: | VAC002 |
Study First Received: | December 8, 2010 |
Last Updated: | December 21, 2011 |
Health Authority: | Hong Kong: Joint CUHK-NTEC Clinical Research Ethics Committee |
Keywords provided by Chinese University of Hong Kong:
histologically confirmed EBV+ NPC patients |
Additional relevant MeSH terms:
Neoplasms Nasopharyngeal Neoplasms Vaccinia Virus Diseases Epstein-Barr Virus Infections Pharyngeal Neoplasms Otorhinolaryngologic Neoplasms Head and Neck Neoplasms Neoplasms by Site |
Nasopharyngeal Diseases Pharyngeal Diseases Stomatognathic Diseases Otorhinolaryngologic Diseases Poxviridae Infections DNA Virus Infections Herpesviridae Infections Tumor Virus Infections Neoplasms, Experimental |
ClinicalTrials.gov processed this record on March 10, 2014


text:
CHARLESTON, W.Va. -- Businesses and nonprofit groups have requested a combined $7.2 million in state grants to bring high-speed Internet to West Virginia's most rural areas.
State Broadband Deployment Council members said Monday that shows there's a growing demand for broadband service across the state. The council plans to distribute $4 million for broadband expansion projects in December.
"There's a pent-up demand," said Lee Fisher, a broadband council member who lives on a farm in Braxton County. "The grant requests exceeded the funds available. Even though some projects might not get funded, this strengthens our case with the governor and Legislature that we need more funding."
As of the middle of last week, not a single company or organization had applied for a council grant. That changed Friday afternoon. The council received 24 applications -- about twice as many as expected.
"All of them seem like solid applications," Fisher said. "They were very professional."
Sixteen companies and organizations requested a combined $5.2 million in state grants to build wireline and wireless broadband networks to homes and businesses in rural areas.
Meanwhile, eight groups requested $1.9 million to promote broadband demand in remote communities where few people have signed up for high-speed Internet, even though broadband is available.
Broadband council Chairman Dan O'Hanlon said the applicant list might shrink. The council plans to reject any incomplete submissions.
"These are just preliminary numbers," O'Hanlon said. "A [council grant review] committee will determine [today] whether the applications are complete. Some may be rejected."
The broadband council plans to post applicant names and project descriptions on the secretary of state's online State Register by Thursday. The council previously decided not to disclose the amount of grant money that each organization requests.
"It will give everyone an opportunity to see what has been proposed, but not the financial information," Fisher said.


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AirfarewatchblogDomestic Flight Deals from AmericanPosted by Tracy Stewart on Friday, March 7, 2014From American Airlines, the latest batch of US Flight Deals are good for travel from March 13 through June 7. Tickets require a 14-day advance purchase, and must be booked by 11:59pm CT, March 13. Sale fares are blacked-out for March 7-9,13-17,20-21,28-30, 2014; April 4-6,11-13,25-27. Fares are valid for travel to Florida and Las Vegas on Sundays through Wednesdays, and from Florida and Las Vegas on Tuesdays through Fridays. Travel is valid for all other destinations Monday through Thursday and Saturday. Other airlines may be matching along some routes. Fares include: Omaha to Phoenix $358 round-trip, including all taxes Santa Ana to Atlanta $350 round-trip, including all taxes Dayton to Washington DC $264 round-trip, including all taxes New Orleans to Miami $278 round-trip, including all taxes Chicago to Manhattan $252 round-trip, including all taxes Mobile to St Louis $281 round-trip, including all taxes Wichita to Portland $304 round-trip, including all taxes Tulsa to Dayton $298 round-trip, including all taxes College Station to New York $284 round-trip, including all taxes Midland to Palm Springs $369 round-trip, including all taxes To learn more, visit Tracy Stewart's profile on Google+
Weekend Fare of the Day: Chicago to NYC $220 round-trip, nonstopPosted by Tracy Stewart on Friday, March 7, 2014A suuuuper weekend fare for last-minute travel! Fly from Chicago to New York for $220 round-trip, including all taxes, on both American and United. Depart from ORD tomorrow, Saturday morning, and return from LGA bright and early on Tuesday. Also available for departures today, returning Monday. For booking info, see our Fare Details. To learn more, visit Tracy Stewart's profile on Google+ 10 Signs You're the Worst Person on Your FlightPosted by Caroline Costello on Friday, March 7, 2014(Photo: Thinkstock/iStock) Are you a candidate for most-hated passenger on the plane? If you're guilty of any of the following bad habits, you'll likely be the subject of disdainful glares, sanctimonious whispers, and violent revenge fantasies on your next flight. Here are 10 signs that you're the human embodiment of all that is wrong with modern air travel. (Photo: Joe Raedle/Getty Images) Your Seat Is in the Lap of the Person Behind You Don't get us wrong: We support seat reclining—within reason. Look behind you. Avoid reclining during mealtime. Maybe don't recline your seat at all if you're sitting in front of Shrek. This is how you can handle that button on the armrest with grace. But passengers who cruelly swing their seats back dentist-chair-style and leave it leaning from takeoff to landing? They give considerate recliners a bad name. Look behind before you recline! (Photo: Gareth Cattermole/Getty Images) You Smell Where are your shoes? If they are not fastened to the ends of your legs, then there is a problem. Don't tell me that your feet don't smell, because according to an extensive body of scientific research, the majority of people with smelly feet are completely unaware that they have smelly feet. And it's more than just your naked extremities: From supersonic farts to smelly snacks to bad breath, there are untold ways to offend the olfactory nerves of your fellow flyers. If you or your belongings emit a perceptible odor, we can pretty much guarantee that everyone in the neighboring rows wants you to go away forever. (Photo: dieter-weinelt via flickr/CC Attribution) Your Kid Is Out of Control The polite tolerance of screaming babies is a generally accepted part of the social contract. A baby can't help screeching like a cat being murdered. Babies cry; this we understand. Out-of-control seven-year-olds are another matter altogether. If your kid is old enough to read (and doesn't live with a sensory-processing disorder or other medical impairment), he or she is expected to follow basic commands such as, "Don't touch that lady's hair." Otherwise, your failings as a parent will be noticeable to everyone on the plane. (Photo: bradleygee via flickr/CC Attribution) You're Captain Grabby Hands If you grab the seat in front of you every time you get up, you are the worst. There's not much more to say about this. Flying is uncomfortable enough without having your seat pulled back and released like a slingshot at unexpected moments. Don't touch anyone's seat unless you're about to fall and it's the only way to prevent a face-plant on the drink cart. (Photo: Scott Gries/Getty Images) You're Loud Yes, Bridesmaids is funny. You like jokes. We get it. But not everyone on the plane is watching the same in-flight feature as you. Many of your seatmates are actually trying to sleep. In the confines of an airplane cabin, your shrill cackle has the auditory effect of squealing breaks or the Aflac duck. Same goes for chewing food with an open mouth, listening to loud music on cheap headphones, playing any kind of game with sound effects, making bodily noises, crying because your vacation is over, or having a boisterous conversation. (Photo: bradleygee via flickr/CC Attribution) You're Feeling Very, Very Friendly In-flight dating apps like Wingman should be illegal. Can't the airlines do something to block usage of these hellish apps that enhance the possibility I'll be reaching for the barf bag? Airplanes are gross enough as it is. Even a platonic attempt at stranger-to-stranger human connection can quickly become inappropriate and aggressive when made in flight. The object of your attention has nowhere to hide in the event that he or she really isn't interested in talking about weekend plans and the weather. So whether you want to make a friend or a "friend," table it until the plane lands. (Photo: hoyasmeg via flickr/CC Attribution) You're Doing Things That Should Only Be Done in Private Use your imagination here. This could include anything from picking at your bare feet to examining your split ends. You might think that your seatmate doesn't notice that you're scratching at the scab on your arm throughout the flight. But trust us—he does. And it's making him uncomfortable. (Photo: Thinkstock/Photodisc) You Think You're a Special Snowflake You may be surprised to learn that you are not the only person on this plane. Look to your left. Look to your right. There are other people! In the event that you are not flying on an empty ghost plane and that you have purchased a coach-class ticket, follow these simple rules: Do not use the flight-attendant call button as your ring-for-service bell. Do not snap your fingers at the flight attendant because you want more ginger ale. Do not spend 30 minutes looking at your phone in the bathroom. Do not ask to switch seats on a full flight because you are in the middle seat and you don't like it. And so on. Basically, pack away your delusions of grandeur and try to behave in a cooperative fashion. If you didn't spring for a ticket upgrade, don't expect a superior, personalized flying experience. (Photo: C Jill Reed via flickr/CC Attribution/Share Alike) You're Drunk One of the worst conceivable places to lose your inhibitions in a sea of SKYY vodka is on a flight. You're packed in a metal tube, where boozed-up conduct that would, at worst, garner an eye roll on the ground could easily attract the attention of federal authorities. Yell and use profanity in your local watering hole? You'll be asked to leave. Yell and use profanity at 30,000 feet? You'll face a police escort and disorderly-conduct charges in federal court. (Photo: Thinkstock/Photodisc) You're Invading Space Your carry-on items are commandeering the floor space of your seatmates. Your butt is in someone's face for an interminable period of time as you wait to use the bathroom. Your fat duffel bag takes up an entire overhead bin. Your elbows are poking across adjacent seats. If these statements describe you, then you're an airplane space invader and you need to be stopped. The solution is easy: Check your oversized bag, and keep your butt and elbows (assuming you know the difference) in check. You Might Also Like:
This article was originally published by SmarterTravel under the title 10 Signs You're the Worst Person on Your Flight. Follow Caroline Costello on Google+ or email him at firstname.lastname@example.com. Domestic Fare of the Day: Philadelphia to Anchorage $378 round-trip, incl. taxesPosted by Tracy Stewart on Friday, March 7, 2014Fly from Philadelphia to Anchorage for $378 round-trip, including all taxes, on United. We found seats departing PHL on Wednesday, April 9, and returning from ANC on Wednesday, April 16. Flights connect in Chicago. Plenty of other dates available within the 330-day travel period, though seats become scarce in peak summer months. Travel is valid any day of the week. For booking info, see our Fare Details. To learn more, visit Tracy Stewart's profile on Google+ Int'l Fare of the Day: San Francisco to Oslo $512 round-trip, incl. all taxesPosted by Tracy Stewart on Friday, March 7, 2014Fly from San Francisco to Oslo for $512 round-trip, including all taxes, on United. We found seats departing SFO on Thursday, September 11, and returning from OSL the following Wednesday, September 17. Other dates available for travel in fall. Fares may vary slightly depending on connecting airports and dates. Visit our Oslo OSL fare page for a look at current fares from other departure cities, including New York JFK for $374 and and Newark EWR for $446. To learn more, visit Tracy Stewart's profile on Google+ Why it's such a good idea to follow @Airfarewatchdog on TwitterBy George Hobica New Service, New Sale from JetBlue: Washington DCA to Nassau $280 nonstopPosted by Tracy Stewart on Thursday, March 6, 2014Fly nonstop from Washington DC to Nassau, Bahamas for $280 round-trip, including all taxes, via JetBlue's new service from Washington-National DCA. We found seats departing DCA on Tuesday, July 8, and returning from NAS the following Tuesday, July 15. Plenty of other dates available for Tuesday/Wednesday travel beginning June 24 through July 30. For booking info, see our Fare Details. Other new routes from DCA include Hartford and Charleston, with intro deals extended to existing nonstop service from DCA. Visit our Washington-National fare page for a complete listing. To learn more, visit Tracy Stewart's profile on Google+ How to make your flight attendant like youBy George Hobica of Airfarewatchdog.com Above image via Shutterstock To learn more, visit George Hobica's profile on Google+ Int'l Fare of the Day: Los Angeles to Copenhagen $448 round-trip, incl. all taxesPosted by Tracy Stewart on Thursday, March 6, 2014Fly from Los Angeles to Copenhagen for $448 round-trip, including all taxes, on United. We found seats departing LAX on Wednesday, March 26, and returning from CPH on Tuesday, April 1. Other dates are also available throughout spring and again in fall/winter. Flights may be operated by Air Canada and SAS, connecting in Toronto or Zurich. Fares may vary slightly depending on connecting airports. For booking info, see our Fare Details. To learn more, visit Tracy Stewart's profile on Google+ Int'l Fare of the Day: Atlanta to Nassau, Bahamas $314 round-trip, nonstopPosted by Tracy Stewart on Wednesday, March 5, 2014Fly from Atlanta to Nassau, Bahamas for $314 round-trip, nonstop, including all taxes, on Delta Air Lines. We found seats departing ATL on Tuesday, April 15, returning from NAS the following Tuesday, April 27. Other dates are also available for travel through May 21. For booking info, see our Fare Details. To learn more, visit Tracy Stewart's profile on Google+ |
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Nothing makes sense anymore!
NBC focuses on domestic athletes, but the Games are a global event, and the perfect chance to share stories about other people and other places.
The Japanese gymnast might be the best there ever was.
What to watch for, from our gymnastics writer.


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Quick View Spot It NHL by Blue Orange Games In Stock $19.95 Whether you are a die-hard hockey fanor you want to break the ice, Spot it NHL edition is perfect Hockey-themed symbols give Spot it its cool edge. To go for the gold, be the first to spot the match Here's your chance to become an expert: the 55 cards that make up this game include each and every… See Details $19.95 was
Quick View Tell Tale by Blue Orange Games In Stock $14.95 Tell Tale is the unique storytelling game where your imagination comes to life. You will take a journey into storyland as you improvise and listen to stories based on a variety of images. The 60 charming cards will take you to unexpected situations with surprising characters. Do you ramble on? No… See Details $14.95 was
Quick View Speedeebee by Blue Orange Games In Stock $17.95 Are you the speediest bee in the hive? Then join in the fun with this ultimate word game With 150 fun challenges and four alphabet dice, players race to find words containing or excluding the letters shown on the dice. May the brightest bee prevail The variety of creative challenges and dice… See Details $17.95 was
Quick View Tell Tale Fairy Tales by Blue Orange Games In Stock $16.95 Drawing inspiration from cards illustrated with whimsical characters and situations, players weave fanciful stories ranging from the romantic to the preposterous. Make up your own enchanting fairy tale or create a communal story with others. The story possibilities are as limitless as your… See Details $16.95 was
Quick View NHL Fastrack by Blue Orange Games In Stock $24.95 NHL® Fastrack brings your favorite sport to your fingertips! Officially licensed by the National Hockey League®, this frenetic game of puck passing produces kinetic energy and exhilarating competition. The game consists of a special NHL® branded wooden tray, detailed to replicate a real hockey… See Details $24.95 was
Quick View Spot It On The Road by Blue Orange Games In Stock $16.95 Spot it has officially hit the open road Each colorful symbol is something you'd see on a typical road trip. This edition includes an additional game variation: players scan the scenery for objects that match the symbols from the cards. Whether you're in the big city, cruising down the highway, or… See Details $16.95 was
Quick View Shrimp Cocktail by Blue Orange Games In Stock $17.95 Keep your eyes peeled as you search the seas for matching shrimp. But beware, other shrimping boats sail these waters and mean to catch the same shrimp you are counting on The shrimp may share any of 4 characteristics: color, origin, quantity and size. Be the first to find a match and squeeze the… See Details $17.95 was


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Rocky Mountain Spotted Fever (RMSF) is an infection caused by the bite of an infected tick. It usually occurs from April until September, but it can occur anytime during the year where weather is warm. The mid-Atlantic and southeastern states are most affected. The disease is spread to humans through a bite from an infected tick; it is not spread from one person to another.
In the U.S., the American dog tick (Dermacentor variabilis), the Rocky Mountain wood tick (Dermacentor andersoni), and the brown dog tick (Rhipicephalus sanguineus), have been identified as vectors that transmit the RMSF bacteria.
The following are the most common symptoms of RMSF. However, each child may experience symptoms differently. Symptoms may include:
A nonitchy rash that usually starts around day 3 on the wrists and ankles, and spreading to the legs and trunk, then palms and soles.
Decreased appetite
Sore throat
Nausea or vomiting
Body aches
Sensitivity to light
RMSF is a serious illness that should be treated as soon as possible. Death has occurred in untreated cases of RMSF.
The symptoms of RMSF may resemble other conditions or medical problems. Always consult your child's doctor for a diagnosis.
Diagnosis is based on symptoms and past history of a tick bite. The appearance and characteristics of the rash are important. Skin biopsy samples and lab tests (antibody titer, kidney function tests, platelet count, prothrombin time, partial thromboplastin time, urinalysis, and red blood cell count) are usually done to rule out other conditions and confirm the diagnosis.
Specific treatment for RMSF will be determined by your child's doctor based on:
Your child's age, overall health, and medical history
Extent of the infection
Your child's tolerance for specific medications, procedures, or therapies
Expectations for the course of the infection
Your opinion or preference
Treatment may include antibiotics and supportive care (care aimed at treating the symptoms present). Doxycycline is the antibiotic of choice, and it will be continued for several days after the fever goes away. Doxycycline is in the tetracycline drug family, and these drugs are usually not given to children under the age of 8 because of the risk of staining the permanent teeth. However, in the case of suspected RMSF, it is more important to treat the illness.
Once a child has RMSF, he or she cannot be reinfected. Some general guidelines for preventing RMSF include the following:
Since ticks cannot bite through clothing; dress your child and family in:
Light-colored clothing so that ticks can be easily seen
Long-sleeved shirts tucked into pants
Socks and closed-toe shoes
Long pants with legs tucked into socks
Check your family often for ticks, including:
All parts of the body that bend: behind the knees, between fingers and toes, underarms, and groin
Other areas where ticks are commonly found: belly button, in and behind the ears, neck, hairline, and top of the head
Areas of pressure points, including:
Where underwear elastic touches the skin
Where bands from pants or skirts touch the skin
Anywhere else where clothing presses on the skin
All other areas of the body and hair, and run fingers gently over skin. Run a fine-toothed comb through your child's hair to check for ticks.
Other helpful measures include:
When possible, walk on cleared paths and pavement through wooded areas and fields.
Shower after all outdoor activities are over for the day. It may take up to four to six hours for ticks to attach firmly to skin. Showering may help remove any loose ticks.
Use insect repellents safely:
Products that contain DEET are tick repellents, but may not kill the tick and are not 100 percent effective. Use a children's insect repellent (20 to 30 percent DEET) and check with your child's doctor if your child is younger than age 1 before using. Do not apply insect repellants around your child's mouth, nose, or eyes, or over cuts or open sores.
Treat clothing with small amounts of a product that contains permethrin, which is known to kill ticks on contact. Do not use permethrin on the skin.
Check pets for ticks and treat as needed.
The third-party content provided in the Health Library of phoebeputney.com is for informational purposes only and is not designed to diagnose or treat a health problem or disease, or replace the professional medical advice you receive from your physician. If you or your child has or suspect you may have a health problem, please consult your primary care physician. If you or your child may have a medical emergency, call your doctor or 911 or other emergency health care provider immediately in the United States or the appropriate health agency of your country. For more information regarding site usage, please visit: Privacy Information, Terms of Use or Disclaimer.
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Phoebe Putney Health System is a network of hospitals, family medicine clinics, rehab facilities, auxiliary services, and medical education training facilities. Founded in 1911, Phoebe Putney Memorial Hospital (the flagship hospital) is one of Georgia's largest comprehensive regional medical centers. From the beginning, Phoebe's mission and vision has been to bring the finest medical talent and technology to the citizens of Southwest Georgia, and to serve all citizens of the community regardless of ability to pay.


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Oh, taste and see that the LORD is good;
Blessed is the man who trusts in Him!"
—The Bible
About Catherine
I am an artist, expressing my heart in song, guitar, and the amazing world of paper craft, jewelry, and needlecraft. My educational background includes 2 years of college, which I chose to leave to spend more time with my teenaged daughters. After years of...
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Catherine's Favorite Books
Bible, Pride and Prejudice, Pursuit of God, Pursuit of Holiness, Crazy Love


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Except for the lucky few who have landed endorsement deals, athletes in winter Olympic sports are chronically underpaid, especially compared to their professional peers. A look at how they measure up.
Starting Saturday, when competition commences at the Sochi Winter Games, U.S. athletes will spend the next 16 days fighting for Olympic glory ... and woefully little prize money.
Except for the lucky ones who have landed profitable endorsement deals, the athletes in winter favorites like downhill skiing, figure skating, and luge are chronically underpaid. That's in part due to monetary bonuses -- $25,000 for gold, $15,000 for silver, $10,000 for bronze -- that the United States Olympic Committee has not increased in at least a decade. (Wach country's committee sets its own prize amounts, and payouts vary considerably.)
Those sums are measly in their own right, but when compared to other professional athletes, they're even more pathetic. Here's how other championship prize money measures up.


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Malthouse (The)
48 Courtenay Place, Wellington, New Zealand 6011Map
+64 4 802 5484
email: email@example.com
Neighborhood: Oriental Bay
This popular bar offers a choice of more than 30 naturally fermented beers on tap. Situated on Wellington's Willis Street, right in the heart of the downtown shopping area, it is readily accessible to locals and visitors alike. Located upstairs in an Edwardian building, the bar features a spacious lounge and bistro serving inexpensive food such as venison pie and fresh fish or pork fillet. There are pool tables for those looking for a diversion and a sunny balcony where patrons can relax and look down on the local street scene.
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Definition of tux in English:
Syllabification: tuxPronunciation: /təks
• informal , chiefly North American- A tuxedo.More example sentences
- People in everything from long gowns and tuxes to blue jeans and baseball caps were waiting patiently to see the show of their choice.
- He snapped his fingers and he was suddenly clad in a sapphire tux with top hat to match her dress.
- If it's a classic tux, it'll last you for years and should never go out of style.


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Relating to something that lends itself to being printed as a slogan or logo on a T-shirt. Also: T-shirtable.
Example Citations:
At a time when the machine was fast becoming the dominant icon of the age, many thinkers saw this wondrous new mechanism as the most elegant way of seeing human endeavour. Inspired by the machines that were beginning to populate the world, from fairground automata to the elaborate clocks decorating churches, they claimed that life could be explained by the same processes of physics and chemistry.
One of the leaders of this movement was the philosopher Rene Descartes. As well as coining one of the world's most T-shirtable slogans, he tried to bring the new mechanistic perspective to bear on the mind/body issue.
Anthony Tasgal, "The science of the brands," International Journal of Market Research, June 22, 2003
Cut to the present, and the Sabres have no trouble throwing millions at a player like Vaclav Varada, a decent talent, but not exactly T-shirt-able. Then again, who on the Sabres really is?
Joshua Maloni, "Shoot for the stars," The Buffalo News, October 27, 2002
Joshua Maloni, "Shoot for the stars," The Buffalo News, October 27, 2002
Earliest Citation:
There is a bunkerlike unit made for viewing next to a glazed administrative office complex alongside a restaurant perched on a high wall next to the oversized, swooping torqued plane of the roof atop the giant I max theater. As for the cone in the center of the complex, which sits above a crater and is composed of two mutually enfolding, tilted arcs about 30 meters high, it should serve as the most T-shirt-able branding device in recent memory.
Liane Lefaivre, "Journey to the center of the earth: Hans Hollein's Vulcania digs deep below the surface for a new museum experience," Architecture, October 1, 2002
Liane Lefaivre, "Journey to the center of the earth: Hans Hollein's Vulcania digs deep below the surface for a new museum experience," Architecture, October 1, 2002
It's a literal sign of the times that if something is popular or controversial, if it's either "hot" or "cool," then some low-end entrepreneur, dollar signs in his eyes and "ka-ching" noises in his ears, will put it on a T-shirt and peddle his one-size-fits-all wares to the public. Some recent examples:
- In April, before American forces had even entered Baghdad, there were T-shirts bearing the likeness of Iraq's Minister for Information, Mohammed Saeed al-Sahhaf, better known now as "Comical Ali."
- Within a couple of weeks of the terrorist attacks of September 11, 2001, T-shirts appeared emblazoned with the words "Let's roll!," Todd Beamer's inspiring last words. (Beamer was one of the passengers on United Airlines Flight 93 who struggled with the terrorists before the plane crashed in a Pennsylvania field.)
- Within days of the 2000 U.S. presidential election and its Florida recount fiasco, T-shirts were being hawked with slogans such as "Stop Electoral Dysfunction" and "Indecision 2000. Whose hole did you punch?"
Naturally, any short slogan that can be slapped on a T-shirt can also be shoehorned onto a car bumper sticker, a phenomenon that has inspired at least one political figure to coin a new adjective:
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NEW YORK, NY - MARCH 13: U.S. Rep. Charles Rangel (D-NY), speaks to the media near the smoking site of an explosion in East Harlem on March 13, 2014 in New York City. At least 7 people were killed, according to reports, in Wednesday's explosion which collapsed two buildings on Park Avenue at 116th Street. (Photo by John Moore/Getty Images)
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Latest Steve Jobs action figure remarkably detailed
You know the holidays are getting close when Steve Jobs action figures start to appear.
We've seen a few toy tributes to Jobs from Chinese companies. There was a kerfuffle in January of this year when Hong Kong toymaker In Icons bowed to pressure from Jobs' family and Apple and withdrew a 12-inch doll from the market.
That hasn't stopped a Japanese startup from trying to cash in on Jobs' popularity. Tokyo-based Legend Toys is releasing its own strikingly detailed 12-inch figure of Jobs. It was sculpted by Takao Kato, whose work includes 1:16 scale and 1:4 scale figures for the otaku market. … Read more


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Bringing Up Baby
Bringing Up Baby | |
Theatrical poster
Directed by | Howard Hawks |
Produced by | Cliff Reid Howard Hawks |
Written by | Dudley Nichols Hagar Wilde Robert McGowan (uncredited) Gertrude Purcell (uncredited) |
Based on | Bringing Up Baby by Hagar Wilde |
Starring | Katharine Hepburn Cary Grant Charles Ruggles Walter Catlett May Robson Fritz Feld |
Music by | Roy Webb (musical director) Jimmy McHugh Dorothy Fields (original writers of I Can't Give You Anything but Love, Baby) |
Cinematography | Russell Metty |
Editing by | George Hively |
Studio | RKO Radio Pictures |
Distributed by | RKO Radio Pictures |
Release dates |
Running time | 102 minutes |
Country | United States |
Language | English |
Budget | $1,096,796.23 |
Box office | $1,109,000 |
Bringing Up Baby is a 1938 American screwball comedy film directed by Howard Hawks, starring Katharine Hepburn and Cary Grant, and released by RKO Radio Pictures.[1][2][3] The film tells the story of a paleontologist in a number of predicaments involving a woman with a unique sense of logic and a leopard named Baby. The supporting cast includes May Robson, Charles Ruggles, Walter Catlett, Barry Fitzgerald and Fritz Feld. The screenplay was adapted by Dudley Nichols and Hagar Wilde from a short story by Wilde which originally appeared in Collier's Weekly magazine on April 10, 1937.[4] Nichols and Wilde began a relationship during their collaboration, and went on to write other screenplays together. Nichols based the relationship between Susan and David partially on the off-screen love affair between Hepburn and director John Ford, which Nichols had observed on the set of Mary of Scotland several years earlier.
The script was written specifically for Hepburn, and was tailored to her personality. Grant was reluctant to take the role, and was chosen after several other leading men turned the part down. Filming began in September 1937 and wrapped in January 1938; it was over schedule and over budget. Hepburn struggled with her comedic performance and was coached by her co-star, vaudeville veteran Walter Catlett. A tame leopard was used during the shooting; its trainer was off-screen with a whip for all its scenes.
Although it has a reputation as a flop upon its release, Bringing up Baby was moderately successful in many cities and eventually made a small profit after its re-release in the early 1940s. Shortly after the film's premiere, Hepburn was labeled box-office poison by the Independent Theatre Owners of America and would not regain her success until The Philadelphia Story two years later. Grant's popularity was beginning to increase during the film's production, and its failure did not hurt his career. Hawks was scheduled to direct an adaptation of Rudyard Kipling's poem "Gunga Din", but was fired by RKO after Bringing Up Baby's disappointing reception; George Stevens directed Gunga Din instead. Grant and Hepburn had previously worked together on 1935's Sylvia Scarlett, and would film Holiday after Bringing Up Baby, and filmed The Philadelphia Story two years later. Grant and Hawks went on to make four more films together.
The film's reputation began to grow during the 1950s, when it was shown on television. In 1972 director Peter Bogdanovich filmed a loose remake of the film entitled What's Up, Doc?. In 1990 Bringing Up Baby was selected for preservation in the National Film Registry of the Library of Congress because it is "culturally, historically, or aesthetically significant", and it has appeared on a number of greatest-films lists. Bringing up Baby is known for Grant's early use of the word "gay" in the context of homosexuality. Although some historians believe the word did not have a homosexual connotation in 1937, film theorists such as Vito Russo contend that the line contained an early example of the euphemism.
David Huxley (Cary Grant) is a mild-mannered paleontologist. For the past four years, he has been trying to assemble the skeleton of a brontosaurus but is missing one bone: the "intercostal clavicle".[5] Adding to his stress is his impending marriage to the dour Alice Swallow (Virginia Walker) and the need to impress Elizabeth Random (May Robson), who is considering a million-dollar donation to his museum.
The day before his wedding, David meets Susan Vance (Katharine Hepburn) by chance on a golf course. She is a free-spirited young lady, and (unknown to him at first) Mrs. Random's niece. Susan's brother, Mark, has sent her a tame leopard from Brazil named Baby (Nissa) to give to their aunt. Susan thinks David is a zoologist (rather than a paleontologist), and persuades David to go to her country home in Connecticut to help bring up Baby (which includes singing "I Can't Give You Anything But Love" to soothe the leopard). Complications arise as Susan falls in love with David and tries to keep him at her house as long as possible to prevent his marriage.
David finally receives the intercostal clavicle, but Susan's dog George (Asta) steals and buries it. Susan's aunt, Elizabeth Random, arrives. The dowager is unaware of David's identity, since Susan has introduced him as "Mr. Bone". Baby and George run off, and Susan and David mistake a dangerous leopard who has escaped from a nearby circus (also portrayed by Nissa) for Baby.
They are jailed by a befuddled town policeman, Constable Slocum (Walter Catlett), for breaking into the house of Dr. Fritz Lehman (Fritz Feld) (where they had cornered the circus leopard). When Slocum does not believe their story, Susan tells him they are members of the "Leopard Gang"; she calls herself "Swingin' Door Susie", and David "Jerry the Nipper" (Irene Dunne's nickname for Grant's character in The Awful Truth, which also featured Asta). David fails to convince the constable that Susan makes things up "from motion pictures she's seen". Eventually, Alexander Peabody (George Irving) shows up to verify everyone's identity. Susan (who has sneaked out a window) unwittingly drags the irritated circus leopard into the jail; David saves her, using a chair to shoo the big cat into a cell.
Several weeks later, Susan finds David (who has been jilted by Alice because of her) working on his brontosaurus reconstruction at the museum. After giving him the missing bone (which she found by trailing George), she tells him she has persuaded her aunt to make the large donation. Against his advice, Susan climbs a tall ladder next to the dinosaur to be closer to him. When the ladder starts swaying from side to side dangerously, she climbs onto the skeleton. Before it collapses, David grabs her hand. Surveying the wreckage of his work, David gives up and admits that he cannot live without her.
- Credited
- Cary Grant as Dr. David Huxley (alias Mr. Bone)
- Katharine Hepburn as Susan Vance
- May Robson as Elizabeth Carlton Random, Susan's aunt
- Charles Ruggles as Major Horace Applegate, a big-game hunter
- Walter Catlett as Constable Slocum
- Barry Fitzgerald as Aloysius Gogarty, Mrs. Random's gardener
- Fritz Feld as Dr. Fritz Lehman, an affluent doctor
- Virginia Walker as Alice Swallow, David's fiancée
- George Irving as Dr. Alexander Peabody, Mrs. Random's lawyer
- Leona Roberts as Mrs. Hannah Gogarty, Aloysius' wife and Mrs. Random's servant
- Tala Birell as Mrs. Lehman, Dr. Lehman's wife
- John Kelly as Elmer, Constable Slocum's assistant
- Uncredited
- D'Arcy Corrigan as Professor LaTouche
- Billy Bevan as Tom, the barkeeper
- Billy Franey as the butcher
- Dick Lane as Circus manager
- Ward Bond as a motorcycle policeman
- Jack Carson as a circus roustabout
- Animal actors
- Skippy as George, Susan's dog
- Nissa as Baby and the circus leopard
Development and writing[edit]
In March 1937 Howard Hawks signed a contract at RKO for an adaptation of Rudyard Kipling's "Gunga Din", which had been in pre-production since the previous fall. When RKO was unable to borrow Clark Gable, Spencer Tracy and Franchot Tone from Metro-Goldwyn-Mayer for the film and Gunga Din was delayed, Hawks began looking for a new project. In April 1937 he read a short story by Hagar Wilde in Collier's magazine called "Bringing Up Baby" and immediately wanted to make a film from it,[6] remembering that it made him laugh out loud.[7] RKO bought the screen rights in June[8] for $1,004, and Hawks worked briefly with Wilde on the film's treatment.[9] Wilde's short story differed significantly from the film: David and Susan are engaged, he is not a scientist and there is no dinosaur, intercostal clavicle or museum. However, Susan gets a pet panther from her brother Mark to give to their Aunt Elizabeth; David and Susan must capture the panther in the Connecticut wilderness with the help of Baby's favorite song, "I Can't Give You Anything but Love, Baby" (there is also a terrier named George).[8]
Hawks then hired screenwriter Dudley Nichols, best known for his work with director John Ford, for the script; Wilde would develop the characters and comedic elements of the script, while Nichols would take care of the story and structure. Hawks worked with the two writers during summer 1937, and they came up with a 202-page script.[10] Wilde and Nichols wrote several drafts together, beginning a romantic relationship and co-authoring the Fred Astaire and Ginger Rogers film Carefree a few months later.[8] The Bringing Up Baby script underwent several changes: at one point there was an elaborate pie fight (inspired by Mack Sennett films). Major Applegate had an assistant and food taster named Ali (meant to be played by Mischa Auer), but this character was replaced with Aloysius Gogarty. The script's final draft had several scenes in the middle of the film in which David and Susan declare their love for each other; Hawks cut the scenes during production.[11]
Nichols was instructed to write the film for Hepburn, with whom he had worked on John Ford's Mary of Scotland in 1936.[12] He had observed Ford's affair with Hepburn, and based many characteristics of Susan and David on Hepburn and Ford (such as David's being placed by Susan in situations wounding his dignity).[13] Nichols was in touch with Ford during the screenwriting,[12] and the film included such members of the John Ford Stock Company as Ward Bond, Barry Fitzgerald, D'Arcy Corrigan and associate producer Cliff Reid.[14] John Ford was a friend of Hawks, and visited the set.[14] The round glasses Grant wears in the film are reminiscent of Harold Lloyd and of Ford.[14]
Filming was initially scheduled to begin on September 1, 1937 and wrap on October 31, but was delayed for several reasons. Production had to wait until mid-September to clear the rights for "I Can't Give You Anything but Love, Baby" for $1,000. In August Hawks hired gag writers Robert McGowan and Gertrude Purcell[15] for uncredited script rewrites, and McGowan added a scene inspired by the comic strip Professor Dinglehoofer and his Dog in which a dog buries a rare dinosaur bone.[11] RKO paid King Features $1,000 to use the idea for the film on September 21.[16]
After briefly considering Hawks' cousin Carole Lombard for the role of Susan Vance, Katharine Hepburn was chosen to play the wealthy New Englander because of her background and similarities to the character. RKO agreed to the casting, but had reservations because of Hepburn's salary and lack of box-office success for several years.[10] Producer Lou Lusty said, "You couldn't even break even if a Hepburn show cost eight hundred grand."[16] At first, Hawks and producer Pandro S. Berman could not agree on who to cast in the role of David Huxley. Hawks initially wanted silent-film comedian Harold Lloyd; Berman rejected Lloyd and Ronald Colman, offering the role to Robert Montgomery, Fredric March and Ray Milland (all of whom turned it down).[17]
Hawks' friend (and Hepburn's sometime-boyfriend) Howard Hughes finally suggested Cary Grant for the role.[18] Grant had just finished shooting his breakthrough romantic comedy The Awful Truth,[10] and Hawks may have seen a rough cut of the unreleased film.[16] Grant then had a non-exclusive, four-picture deal with RKO for $50,000 per film. Grant's manager used his casting in the film to renegotiate Grant's contract, earning him $75,000 plus the bonuses Hepburn was receiving.[17] Grant was initially concerned about being able to play an intellectual character and took two weeks to accept the role, despite the new contract. Hawks built Grant's confidence by promising to coach him throughout the film, instructing him to watch Harold Lloyd films for inspiration.[19] Grant met with Howard Hughes throughout the film to discuss his character, which he said helped his performance.[19]
Hawks obtained character actors Charlie Ruggles on loan from Paramount Pictures for Major Horace Applegate and Barry Fitzgerald on loan from The Mary Pickford Corporation to play gardener Aloysius Gogarty.[10] Hawks cast Virginia Walker as Alice Swallow, David's fiancée. Walker was under contract to him, later marrying his brother William Hawks.[20] Hawks could not find a panther that would work for the film; Baby was changed to a leopard so they could cast the trained leopard Nissa (who had worked in films for eight years, making several B-movies).[16]
Shooting began September 23, 1937 and was scheduled to end November 20, 1937[21] on a budget of $767,676.[22] Filming began in-studio with the scenes in Susan's apartment, moving to the Bel Air Country Club in early October for the golf-course scenes.[16] The production had a difficult start due to Hepburn's struggles with her character and her comedic abilities. She frequently overacted, trying too hard to be funny,[22] and Hawks asked vaudeville veteran Walter Catlett to help coach her. Catlett acted out scenes with Grant for Hepburn, showing her that he was funnier when he was serious. Hepburn understood, acted naturally and played herself for the rest of the shoot; she was so impressed by Catlett's talent and coaching ability that she insisted he play Constable Slocum in the film.[23][24]
Most shooting was done at the Arthur Ranch in the San Francisco Valley, which was used as Aunt Elizabeth's estate for interior and exterior scenes.[16] Beginning at the Arthur Ranch shoot,[25] Grant and Hepburn often ad-libbed their dialogue; production was delayed as the two stars ruined shots by making each other laugh.[26] The scene where Grant frantically asks Hepburn where his bone is was shot from 10 am until well after 4 pm because of the stars' laughing fits.[27] The film was further delayed, and after one month of shooting Hawks was seven days behind schedule. During the filming, Hawks would refer to four different versions of the film's script and make frequent changes to scenes and dialogue.[25] Some delays were caused by Hawks' leisurely attitude on set; on several occasions he shut down production so cast and crew could see a horse race,[27] and he took twelve days to shoot the Westlake jail scene instead of the scheduled five.[25]
Hawks later blamed the delays on his two stars' laughing fits and having to work with two animal actors.[27] The terrier George was played by Skippy, known as Asta in The Thin Man film series and co-starring with Grant (as Mr. Smith) in The Awful Truth. The tame leopard Baby and the escaped circus leopard were both played by a trained leopard, Nissa. The big cat was supervised by its trainer, Olga Celeste, who stood by with a whip during shooting. At one point, when Hepburn spun around (causing her skirt to twirl) Nissa lunged at her and was subdued when Celeste cracked her whip. Hepburn wore heavy perfume to keep Nissa calm. While Hepburn was unafraid of the leopard, Grant was terrified; most scenes of the two interacting are done in close-up with a stand-in. During filming, Hepburn threw a toy leopard through the roof of Grant's dressing room.[27] During the shooting, there were several news reports about Hawks' difficulty filming a live leopard; some scenes required rear-screen projection.[28]
Hawks and Hepburn had a confrontation one day during shooting. While Hepburn was chatting with a crew member, Hawks yelled "Quiet!" until the only person still talking was Hepburn. When Hepburn paused and realized that everyone was looking at her, she asked what was the matter; Hawks asked her if she was finished imitating a parrot. Hepburn took Hawks aside, telling him never to talk to her like that again since she was old friends with most of the crew. When Hawks (an older friend of the crew) asked a lighting tech who he would rather drop a light on, Hepburn agreed to behave on set. A variation of this scene (with Grant yelling "Quiet!") was incorporated into the film.[24][29]
Filming was completed on January 6, 1938 with the scenes outside Mr. Peabody's house;[30] other shooting locations included the Westlake Street set at 20th Century Fox Studios.[15] RKO producers were concerned about the film's delays, Grant's glasses and Hepburn's hair.[29] Bringing Up Baby came in 40 days over schedule and $330,000 over budget. The film's final cost was $1,096,796.23, primarily due to overtime clauses in Hawks', Grant's and Hepburn's contracts.[21] The film's cost for sets and props was only $5,000 over budget, but all actors (including Nissa and Skippy) were paid approximately double their initial salaries. Hepburn's salary rose from $72,500 to $121,680.50, Grant's salary from $75,000 to $123,437.50 and Hawks' salary from $88,046.25 to $202,500. The director received an additional $40,000 to terminate his RKO contract on March 21, 1938.[31]
Post-production and previews[edit]
Hawks' editor, George Hively, cut the film during production and the final prints were made a few days after shooting ended.[21] The first cut of the film (10,150 feet long)[30] was sent to the Hayes Office in mid-January.[32] Despite several double entendres and sexual references it passed the film,[21] overlooking Grant saying he "went gay" or Hepburn's reference to George urinating. The censor's only objections were to the scene where Hepburn's dress is torn, and references to politicians (such as Al Smith and Jim Farley).[32]
Like all Hawks' comedies, the film is known for its fast pace (despite being filmed primarily in long medium shots, with little cross-cutting). Hawks told Peter Bogdanovich, "You get more pace if you pace the actors quickly within the frame rather than cross cutting fast".[28]
By February 18, the film had been cut to 9,204 feet.[32] It had two advance previews in January 1938, where it received either As or A-pluses on audience-feedback cards. Producer Pandro S. Berman wanted to cut five more minutes, but relented when Hawks, Grant and Cliff Reid objected.[32] At the film's second preview, the film received rave reviews and RKO expected a hit.[21] The film's musical score is minimal, primarily Grant and Hepburn singing "I Can't Give You Anything But Love, Baby". There is incidental music in the Ritz scene, and an arrangement of "I Can't Give You Anything But Love, Baby" during the opening and closing credits by musical director Roy Webb.[33]
Reception and box office[edit]
The film received good advance reviews, and RKO expected a hit. Otis Ferguson of The New Republic thought the film very funny, praising Hawks' direction.[34] In a Variety review "Wear" praised the film, singling out Hawks' pacing and direction, calling Hepburn's performance "one of her most invigorating screen characterizations" and saying Grant "performs his role to the hilt";[35] their only criticism was the length of the jail scene.[36] Frank S. Nugent of the New York Times disliked the film, considering it derivative and cliché-ridden, a rehash of dozens of other screwball comedies of the period. He labeled Hepburn's performance "breathless, senseless, and terribly, terribly fatiguing",[37] and added, "If you've never been to the movies, Bringing Up Baby will be new to you - a zany-ridden product of the goofy-farce school. But who hasn't been to the movies?"[38]
Despite Bringing Up Baby's reputation as a flop, it was successful in parts of the U.S. The film premiered on Valentine's Day 1938 at the Golden Gate Theater in San Francisco (where it was a hit), and was also successful in Los Angeles, Portland, Denver, Cincinnati and Washington, D.C. However, it was a financial disappointment in the Midwest and most other cities in the country. To RKO's chagrin, the film's premiere in New York on March 3, 1938 at Radio City Music Hall made only $70,000 and it was pulled after one week[39] in favor of Jezebel with Bette Davis.[40] During its initial run, the film incurred a loss of $365,000[41] (if Hawks' $40,000 buyout fee is added to the film's budget).[citation needed]
During its first run, Bringing Up Baby made $715,000 in the U.S. and $394,000 in foreign markets for a total of $1,109,000;[31] its reissue in 1940 and 1941 made an additional $95,000 domestically[specify] and $55,000 in foreign markets[specify].[39] Following its second run, the film made a profit of $163,000.[31] Due to its perceived failure, Hawks was released early from his two-film contract with RKO[31] and Gunga Din was eventually directed by George Stevens.[42] Hawks later said the film "had a great fault and I learned an awful lot from that. There were no normal people in it. Everyone you met was a screwball and since that time I learned my lesson and don't intend ever again to make everybody crazy".[43] The director went on to work with RKO on three films over the next decade.[44] Shortly after Bringing Up Baby's release, Hepburn was labeled "box-office poison" by Harry Brandt (president of the Independent Theatre Owners of America)[45][39][46] and allowed to buy out her RKO contract for $22,000.[47][42] However, many critics marveled at her new skill at low comedy; Life magazine called her "the surprise of the picture".[48] Howard Hughes bought RKO in 1941, and sold it in 1959; when he sold the company, Hughes retained the copyright to six films (including Bringing Up Baby).[44]
This section needs additional citations for verification. (November 2013) |
Bringing Up Baby was the second of four films starring Grant and Hepburn; the others were Sylvia Scarlett (1935), Holiday (1938) and The Philadelphia Story (1940). Their last three belong to a sub-genre of screwball comedy known as the comedy of remarriage, described by philosopher Stanley Cavell as Hollywood's crowning achievement. Cavell noted that Bringing Up Baby was made in a tradition of romantic comedy with roots from ancient Rome to Shakespeare.[49]
The popularity of Bringing Up Baby has increased since it was shown on television during the 1950s, and by the 1960s film analysts (including the writers at Cahiers du Cinema in France) affirmed the film's quality. In a rebuttal of fellow New York Times critic Nugent's scathing review of the film at the time of release, A. O. Scott has said that you'll "find yourself amazed at its freshness, its vigor, and its brilliance-qualities undiminished after sixty-five years, and likely to withstand repeated viewings."[38] Leonard Maltin stated that it is now "considered the definitive screwball comedy, and one of the fastest, funniest films ever made; grand performances by all."[38]
Bringing Up Baby has been adapted several times. Hawks recycled the nightclub scene in which Hepburn's dress is torn and Grant walks behind her in the 1964 comedy, Man's Favorite Sport. Peter Bogdanovich's 1972 film What's Up, Doc?, starring Barbra Streisand, was intended as an homage to the film, and has contributed to its reputation.[43] In the commentary track for Bringing Up Baby, Bogdanovich discusses how the coat-ripping scene in What's Up, Doc? was based on the scene in which Grant's coat and Hepburn's dress are torn in Bringing Up Baby.[28] The 1987 film Who's That Girl?, starring Madonna, is also loosely based on Bringing Up Baby.[50]
In 1990 (the registry's second year), Bringing Up Baby was selected for preservation in the National Film Registry of the Library of Congress as "culturally, historically, or aesthetically significant". Entertainment Weekly voted the film 24th on its list of greatest films. In 2000, readers of Total Film magazine voted it the 47th-greatest comedy film of all time. Premiere ranked Cary Grant's performance as Dr. David Huxley 68th on its list of 100 all-time greatest performances,[51] and ranked Susan Vance 21st on its list of 100 all-time greatest movie characters.[52]
- American Film Institute recognition
- [53]
The American Film Institute included the film on its list of the 100 greatest American films of all time, and it was named the fourteenth-funniest American film of all time. "Bringing Up Baby" has been used several times as a TV-episode title.
- AFI's 100 Years...100 Movies: #97
- AFI's 100 Years...100 Laughs: #14
- AFI's 100 Years...100 Passions: #51
- AFI's 100 Years...100 Movie Quotes (nominated): "It isn't that I don't like you, Susan, because after all, in moments of quiet, I'm strangely drawn toward you; but, well, there haven't been any quiet moments!"
- AFI's 100 Years...100 Movies (10th Anniversary Edition): #88
- AFI's 10 Top 10 (nominated): Romantic comedy
Use of "gay"[edit]
It is debated whether Bringing Up Baby is the first fictional work (apart from pornography) to use the word "gay" in a homosexual context.[54][55] In one scene, Cary Grant's character is wearing a woman's marabou-trimmed négligée; when asked why, he replies exasperatedly "Because I just went gay all of a sudden!" (leaping into the air at the word "gay"). It is uncertain whether the word is used in its older sense (meaning "happy"[56]) or is an intentional, joking reference to homosexuality.
According to Robert Chapman's Dictionary of American Slang, the adjective "gay" was used by homosexuals among themselves since at least 1920. Donald Webster Cory writes in his 1951 The Homosexual in America, "Psychoanalysts have informed me that their homosexual patients were calling themselves gay in the nineteen-twenties, and certainly by the nineteen-thirties it was the most common word in use by homosexuals themselves". However, it was not in common use. Cory maintained that it was such an insider's term that "an advertisement for a roommate can actually ask for a gay youth, but could not possibly call for a homosexual."[57][58] The term "gay" did not become familiar to the general public until the Stonewall riots in 1969.[59]
In the film, the word "gay" was an ad-lib by Grant and not in any version of the original script.[25] According to Vito Russo in The Celluloid Closet (1981, revised 1987), the script originally had Grant's character say "I...I suppose you think it's odd, my wearing this. I realize it looks odd...I don't usually...I mean, I don't own one of these". Russo suggests that this indicates that people in Hollywood (at least in Grant's circles) were familiar with the slang connotations of the word; however, neither Grant nor anyone involved in the film suggested this.[59]
This article includes inline citations, but they are not properly formatted. (November 2013) |
- ^ eMoviePoster.com
- ^ Variety film review; February 16, 1938, page 15.
- ^ Harrison's Reports film review; February 19, 1938, page 31.
- ^ Brown, Gene (1995). Movie Time: A Chronology of Hollywood and the Movie Industry from its Beginnings to the Present. New York: MacMillan. p. 135. ISBN 0-02-860429-6.
- ^ Cavell, Stanley (1994) [1988]. "Leopards in Connecticut". In Mast, Gerald. Bringing Up Baby. Rutgers Films in Print 10. New Brunswick, New Jersey: Rutgers University Press. p. 280. ISBN 0-8135-1340-5. OCLC 639835277. Retrieved October 21, 2011. "Its mythical name, the intercostal clavicle, suggests that it belongs to creatures whose heads are beneath their shoulders, or anyway whose shoulders are beneath at least some of their ribs."
- ^ Mast 1988, pp. 4.
- ^ Eliot 2004, pp. 175.
- ^ a b c Mast 1988, pp. 5.
- ^ McCarthy 1997, pp. 246.
- ^ a b c d McCarthy 1997, pp. 247.
- ^ a b Mast 1988, pp. 6.
- ^ a b Leaming 1995, pp. 348.
- ^ Leaming 1995, pp. 348-349.
- ^ a b c Leaming 1995, pp. 349.
- ^ a b Mast 1988, pp. 29.
- ^ a b c d e f Mast 1988, pp. 7.
- ^ a b Eliot 2004, pp. 176-177.
- ^ Eliot 2004, pp. 174.
- ^ a b Eliot 2004, pp. 178.
- ^ McCarthy 1997, pp. 248.
- ^ a b c d e McCarthy 1997, pp. 254.
- ^ a b McCarthy 1997, pp. 250.
- ^ McCarthy 1997, pp. 250-251.
- ^ a b Mast 1988, pp. 261.
- ^ a b c d Mast 1988, pp. 8.
- ^ McCarthy 1997, pp. 251.
- ^ a b c d McCarthy 1997, pp. 252.
- ^ a b c Bringing Up Baby DVD. Special Features. Peter Bogdanovich Audio Commentary. Turner Home Entertainment. 2005.
- ^ a b McCarthy 1997, pp. 253.
- ^ a b Mast 1988, pp. 12.
- ^ a b c d Mast 1988, pp. 14.
- ^ a b c d Mast 1988, pp. 13.
- ^ Mast 1988, pp. 9.
- ^ Mast 1988, pp. 268.
- ^ Mast 1988, pp. 266.
- ^ Mast 1988, pp. 267.
- ^ Mast 1988, pp. 265.
- ^ a b c Laham 2009, p. 29.
- ^ a b c McCarthy 1997, pp. 255.
- ^ Brown, Gene (1995), Movie Time: A Chronology of Hollywood and the Movie Industry from Its Beginnings to the Present, New York: MacMillan, p. 140, ISBN 0-02-860429-6
- ^ Richard Jewel, 'RKO Film Grosses: 1931-1951', Historical Journal of Film Radio and Television, Vol 14 No 1, 1994 p57
- ^ a b McCarthy 1997, pp. 257.
- ^ a b McCarthy 1997, pp. 256.
- ^ a b Mast 1988, pp. 16.
- ^ Eliot 2004, pp. 180-181.
- ^ Mahar, Ted (March 4, 2005). "Movie Review: The Hepburn Story, Katharine Hepburn's Career is Back in the Spotlight". The Oregonian. p. 46.
- ^ Eliot 2004, pp. 181.
- ^ Mast 1988, pp. 15.
- ^ Mast 1988, pp. 3.
- ^ "'Who's That Girl' (PG)". The Washington Post. 1987-08-08. Retrieved 2014-03-09.
- ^ Premiere Magazine. The 100 Greatest Performances of All Time. Hachette Filipacchi Media U.S.. April 2004. Access date: 2013-11-18
- ^ Premiere Magazine. The 100 Greatest Characters of All Time. Hachette Filipacchi Media U.S.. April 2006. Access date: 2013-11-18.
- ^ "AFI's 100 YEARS". afi.com. Retrieved 2014-03-09.
- ^ "Censored Films and Television at University of Virginia online". University of Virginia Library. Retrieved 2014-03-09.
- ^ Boswell, John (1980). Christianity, Social Tolerance, and Homosexuality. Chicago: University of Chicago Press. p. 43.
- ^ Harper, Douglas (2001–2013). "Gay". Online Etymology dictionary.
- ^ Smith, Bonnie G. (2000). Global feminisms since 1945. Psychology Press. Retrieved 2010-03-07.
- ^ Sinfeld, Alan (1999). Out on stage: lesbian and gay .... Yale University Press. Retrieved 2010-03-07.
- ^ a b Vito Russo, The Celluloid Closet: Homosexuality in the Movies (revised edition, Harper & Row, 1987), p. 47
- Eliot, Marc (2004). Cary Grant: A Biography. New York: Harmony Books. ISBN 978-0307209832.
- Laham, Nicholas (1 January 2009). Currents of Comedy on the American Screen: How Film and Television Deliver Different Laughs for Changing Times. McFarland. ISBN 978-0-7864-5383-2.
- Leaming, Barbara (1995). Katharine Hepburn. New York: Crown Publishers, Inc. ISBN 978-0879102937.
- Mast, Gerald (1988). Bringing Up Baby. Howard Hawks, director. New Brunswick and London: Rutgers University Press. ISBN 978-0813513416.
- Mast, Gerald (1982). Howard Hawks, storyteller. New York and Oxford: Oxford University Press. ISBN 978-0195032338.
- McCarthy, Todd (1997). Howard Hawks: The Grey Fox of Hollywood. New York: Grove Press. ISBN 978-0802137401.
- Swaab, Peter (2011). Bringing Up Baby. London: British Film Institute. ISBN 978-1844570706.
External links[edit]
Wikiquote has a collection of quotations related to: Bringing Up Baby |
Wikimedia Commons has media related to Bringing Up Baby. |
- Bringing Up Baby at the Internet Movie Database
- Bringing Up Baby at allmovie
- Bringing Up Baby at the TCM Movie Database
- Pauline Kael analysis
- Bringing Up Baby at moviediva
- Reprints of historic reviews, photo gallery at CaryGrant.net
- Bringing Up Baby on Theater of Romance: July 24, 1945


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Home › Reviews › Graphics Cards
Battlefield 3 Beta Performance Test
Published October 4, 2011
Of course, there's a beta for a reason and we have to try and treat it as such. The night after the beta went live our editor Matthew DeCarlo organized a Friday Night Fragfest (we host such an event every Friday night), so I felt it was best to ask him about his impressions of the game.
Matt felt the game's graphics were great -- especially if the final version is going to be even better -- and that the audio was fantastic. However the gameplay could only be described as buggy. There were problems that caused people to glitch into things they shouldn't have, while the hit detection is also very poor. Matt wasnt keen on the beta map either or the game mode which required too much crawling around and he went on The menu system is best described as a cruel joke and he found the chat box oddly placed at the top and somewhat to the right of the screen making the chat UI feel amateurish.
In a nutshell, initial impressions on gameplay are not great but this is a very limited beta, so we will leave it at that. Still it's scary to think how much work DICE has yet to get done in less than a month for Battlefield 3 to succeed.
As for my impressions on how well the game performs, BF3 certainly looks great when using the high quality settings but I'm not sure the visuals justify ~50fps out of the GeForce GTX 580 at 1920x1200 and 45fps from the Radeon HD 6970. The ultra settings are not fully developed so I won't comment on them.
For a game that was seen utilizing six threads quite efficiently, we were pleased to see that the dual-core Phenom II X2 was just 20% slower than a similar configured quad-core processor.
It's been nice to see AMD and Nvidia competing so aggressively to deliver improved support and compatibility for Battlefield 3. Testing revealed that both Crossfire and SLI worked well, though every now and then flickering glitches were noticed when using either technology. A large number of gamers are reporting flickering issues with single GPU configurations as well, so this is another issue that will needed to be addressed before the game is released.
The Battlefield 3 beta has somewhat disappointed as we were hoping to see a more polished game just a month away from release. That said we'll reserve final judgment until then and expect a detailed performance analysis once Battlefield 3 is officially released.
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The Joy of CookingIrma S. Rombauer; Ethan Becker; Marion Rombauer Becker; Irma Von Starkloff RombauerISBN:9780743284301Publisher:ScribnerPublication Date:2008Binding:SoftcoverSynopsis: More About this Book | View All Listings | View Collectible Listings Other editions: 2008, 2007, Hardcover - 2006, Softcover - 2004, Hardcover - 2002, Hardcover - 2002, Hardcover - 2002, 2002, Hardcover - 2002, Hardcover - 2001 |
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