text:
Hepatitis D
Hepatitis D | |
Virus classification | |
Group: | Group V ((-)ssRNA) |
Order: | Unassigned |
Family: | Unassigned |
Genus: | Deltavirus |
Species: | Hepatitis delta virus |
Hepatitis D | |
Classification and external resources | |
DiseasesDB | 5792 |
MeSH | D003699 |
Hepatitis D, also referred to as hepatitis D virus (HDV) and classified as Hepatitis delta virus, is a disease caused by a small circular enveloped RNA virus. It is one of five known hepatitis viruses: A, B, C, D, and E. HDV is considered to be a subviral satellite because it can propagate only in the presence of the hepatitis B virus (HBV).[1] Transmission of HDV can occur either via simultaneous infection with HBV (coinfection) or superimposed on chronic hepatitis B or hepatitis B carrier state (superinfection).
Both superinfection and coinfection with HDV results in more severe complications compared to infection with HBV alone. These complications include a greater likelihood of experiencing liver failure in acute infections and a rapid progression to liver cirrhosis, with an increased chance of developing liver cancer in chronic infections.[2] In combination with hepatitis B virus, hepatitis D has the highest mortality rate of all the hepatitis infections, at 20%.
Hepatitis D virus was first reported in the mid-1977 as a nuclear antigen in patients infected with HBV who had severe liver disease.[3] This nuclear antigen was then thought to be a hepatitis B antigen and was called the delta antigen. Subsequent experiments in chimpanzees showed that the hepatitis delta antigen (HDAg) was a structural part of a pathogen that required HBV infection to replicate[4] The entire genome was cloned and sequenced in 1986. It was subsequently placed in its own genus: Deltavirus.[5][6]
Structure and genome[edit]
Hepatitis delta virus delta antigen | |||||||||
oligomerization domain of hepatitis delta antigen
Identifiers | |||||||||
Symbol | HDV_ag | ||||||||
Pfam | PF01517 | ||||||||
InterPro | IPR002506 | ||||||||
SCOP | 1a92 | ||||||||
SUPERFAMILY | 1a92 | ||||||||
The HDV is a small, spherical virus with a 36 nm diameter. It has an outer coat containing three HBV envelope proteins (called large, medium, and small hepatitis B surface antigens), and host lipids surrounding an inner nucleocapsid. The nucleocapsid contains single-stranded, circular RNA of 1679 nucleotides and about 200 molecules of hepatitis D antigen (HDAg) for each genome. The central region of HDAg has been shown to bind RNA.[7] Several interactions are also mediated by a coiled-coil region at the N terminus of HDAg.[8] The hepatitis D circular genome is unique to animal viruses because of its high GC nucleotide content. The HDV genome exists as an enveloped, negative sense, single-stranded, closed circular RNA. Its nucleotide sequence is 70% self-complementary, allowing the genome to form a partially double-stranded, rod-like RNA structure.[9] With a genome of approximately 1700 nucleotides, HDV is the smallest "virus" known to infect animals. It has been proposed that HDV may have originated from a class of plant pathogens called viroids, which are much smaller than viruses.[10][11]
Life cycle[edit]
The receptor that HDV recognizes on human hepatocytes has not been identified; however it is thought to be the same as the HBV receptor because both viruses have the same outer coat.[12] HDV recognizes its receptor via the N-terminal domain of the large hepatitis B surface antigen, HBsAg.[13] Mapping by mutagenesis of this domain has shown that amino acid residues 9–15 make up the receptor binding site.[14] After entering the hepatocyte, the virus is uncoated and the nucleocapsid translocated to the nucleus due to a signal in HDAg[15] Since the nucleocapsid does not contain an RNA polymerase to replicate the virus' genome, the virus makes use of the cellular RNA polymerases. Initially just RNA pol II,[16][17] now RNA polymerases I and III have also been shown to be involved in HDV replication[18] Normally RNA polymerase II utilizes DNA as a template and produces mRNA. Consequently, if HDV indeed utilizes RNA polymerase II during replication, it would be the only known animal pathogen capable of using a DNA-dependent polymerase as an RNA-dependent polymerase.
The RNA polymerases treat the RNA genome as double stranded DNA due to the folded rod-like structure it is in. Three forms of RNA are made; circular genomic RNA, circular complementary antigenomic RNA, and a linear polyadenylated antigenomic RNA, which is the mRNA containing the open reading frame for the HDAg. Synthesis of antigenomic RNA occurs in the nucleolus, mediated by RNA Pol I, whereas synthesis of genomic RNA takes place in the nucleoplasm, mediated by RNA Pol II.[19] HDV RNA is synthesized first as linear RNA that contains many copies of the genome. The genomic and antigenomic RNA contain a sequence of 85 nucleotides, the Hepatitis delta virus ribozyme, that acts as a ribozyme, which self-cleaves the linear RNA into monomers. These monomers are then ligated to form circular RNA.[20][21]
There are eight reported genotypes of HDV with unexplained variations in their geographical distribution and pathogenicity.
Delta antigens[edit]
A significant difference between viroids and HDV is that, while viroids produce no proteins, HDV is known to produce one protein, namely HDAg. It comes in two forms; a 27kDa large-HDAg, and a small-HDAg of 24kDa. The N-terminals of the two forms are identical, they differ by 19 more amino acids in the C-terminal of the large HDAg.[22] Both isoforms are produced from the same reading frame which contains an UAG stop codon at codon 196, which normally produces only the small-HDAg. However, editing by cellular enzyme adenosine deaminase-1 changes the stop codon to UCG, allowing the large-HDAg to be produced.[22][23] Despite having 90% identical sequences, these two proteins play diverging roles during the course of an infection. HDAg-S is produced in the early stages of an infection and enters the nucleus and supports viral replication. HDAg-L, in contrast, is produced during the later stages of an infection, acts as an inhibitor of viral replication, and is required for assembly of viral particles.[24][25][26] Thus RNA editing by the cellular enzymes is critical to the virus' life cycle because it regulates the balance between viral replication and virion assembly.
The routes of transmission of hepatitis D are similar to those for hepatitis B. Infection is largely restricted to persons at high risk of hepatitis B infection, particularly injecting drug users and persons receiving clotting factor concentrates. Worldwide more than 15 million people are co-infected. HDV is rare in most developed countries, and is mostly associated with intravenous drug use. However, HDV is much more common in the immediate Mediterranean region, sub-Saharan Africa, the Middle East, and the northern part of South America.[27] In all, about 20 million people may be infected with HDV.[28]
Treatment and prevention[edit]
The vaccine for hepatitis B protects against hepatitis D virus because of the latter's dependence on the presence of hepatitis B virus for it to replicate.[29][30]
Low quality evidence suggests that interferon alpha can be effective in reducing the severity of the infection and the effect of the disease during the time the drug is given, but the benefit generally stops when the drug is discontinued, indicating that it does not cure the disease.[31] Interferon is effective only in ~20% of cases.[32]
Three genotypes (I–III) were originally described. Genotype I has been isolated in Europe, North America, Africa and some Asia. Genotype II has been found in Japan, Taiwan, and Yakutia (Russia). Genotype III has been found exclusively in South America (Peru, Colombia, and Venezuela). Some genomes from Taiwan and the Okinawa islands have been difficult to type but have been placed in genotype 2. However it is now known that there are at least 8 genotypes of this virus (HDV-1 to HDV-8).[33] Phylogenetic studies suggest an African origin for this pathogen.[34]
An analysis of 36 strains of genotype 3 estimated that the most recent common ancestor of these strains originated around 1930.[35] This genotype spread exponentially from early 1950s to the 1970s in South America. The substitution rate was estimated to be 1.07×10−3 substitutions per site per year.
Genotype 8 has also been isolated from South America. This genotype is usually only found in Africa and may have been imported into South America during the slave trade.[36]
Genotypes, with the exception of type 1, appear to be restricted to certain geographical areas: HDV-2 (previously HDV-IIa) is found in Japan, Taiwan and Yakoutia, Russia; HDV-4 (previously HDV-IIb) in Japan and Taiwan; HDV-3 in the Amazonian region; HDV-5, HDV-6, HDV-7 and HDV-8 in Africa.[37]
See also[edit]
- ^ Makino S, Chang MF, Shieh CK et al. (1987). "Molecular cloning and sequencing of a human hepatitis delta (delta) virus RNA". Nature 329 (6137): 343–6. doi:10.1038/329343a0. PMID 3627276.
- ^ Fattovich G, Giustina G, Christensen E et al. (March 2000). "Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B". Gut 46 (3): 420–6. doi:10.1136/gut.46.3.420. PMC 1727859. PMID 10673308.
- ^ Rizzetto, M; Canese MG, Arico S, Criello O, Trepo C, Bonino F, Verme G (1977). "Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers". Gut 18 (12): 997–1003. doi:10.1136/gut.18.12.997. PMC 1411847. PMID 75123.
- ^ Rizzetto, M; Canese, MG, Purcell, RH, London, WT, Sly, LD, Gerin, JL (1981 Nov–Dec). "Experimental HBV and delta infections of chimpanzees: occurrence and significance of intrahepatic immune complexes of HBcAg and delta antigen". Hepatology (Baltimore, Md.) 1 (6): 567–74. doi:10.1002/hep.1840010602. PMID 7030907.
- ^ Wang, KS; Choo, QL, Weiner, AJ, Ou, JH, Najarian, RC, Thayer, RM, Mullenbach, GT, Denniston, KJ, Gerin, JL, Houghton, M (1986 Oct 9–15). "Structure, sequence and expression of the hepatitis delta (delta) viral genome". Nature 323 (6088): 508–14. doi:10.1038/323508a0. PMID 3762705.
- ^ Fauquet, CM; Mayo MA, Maniloff J, Desselberger U, Ball LA (2005). "Deltavirus". Eight Report of the International Committee on Taxonomy of Viruses. London: 735–8.
- ^ Poisson F, Roingeard P, Baillou A, Dubois F, Bonelli F, Calogero RA, Goudeau A (November 1993). "Characterization of RNA-binding domains of hepatitis delta antigen". J. Gen. Virol. 74 (Pt 11): 2473–8. doi:10.1099/0022-1317-74-11-2473. PMID 8245865.
- ^ Zuccola HJ, Rozzelle JE, Lemon SM, Erickson BW, Hogle JM (July 1998). "Structural basis of the oligomerization of hepatitis delta antigen". Structure 6 (7): 821–30. doi:10.1016/S0969-2126(98)00084-7. PMID 9687364.
- ^ Saldanha JA, Thomas HC, Monjardino JP (July 1990). "Cloning and sequencing of RNA of hepatitis delta virus isolated from human serum". J. Gen. Virol. 71 (7): 1603–6. doi:10.1099/0022-1317-71-7-1603. PMID 2374010.
- ^ Elena SF, Dopazo J, Flores R, Diener TO, Moya A (July 1991). "Phylogeny of viroids, viroidlike satellite RNAs, and the viroidlike domain of hepatitis delta virus RNA". Proc. Natl. Acad. Sci. U.S.A. 88 (13): 5631–4. doi:10.1073/pnas.88.13.5631. PMC 51931. PMID 1712103.
- ^ Sureau, C (2006). "The role of the HBV envelope proteins in the HDV replication cycle". Current topics in microbiology and immunology. Current Topics in Microbiology and Immunology 307: 113–31. doi:10.1007/3-540-29802-9_6. ISBN 978-3-540-29801-4. PMID 16903223.
- ^ Barrera, A; Guerra, B, Notvall, L, Lanford, RE (August 2005). "Mapping of the Hepatitis B Virus Pre-S1 Domain Involved in Receptor Recognition". Journal of Virology 79 (15): 9786–98. doi:10.1128/JVI.79.15.9786-9798.2005. PMC 1181564. PMID 16014940.
- ^ Engelke, M; Mills, K, Seitz, S, Simon, P, Gripon, P, Schnölzer, M, Urban, S (April 2006). "Characterization of a hepatitis B and hepatitis delta virus receptor binding site". Hepatology (Baltimore, Md.) 43 (4): 750–60. doi:10.1002/hep.21112. PMID 16557545.
- ^ Schulze, A; Schieck, A, Ni, Y, Mier, W, Urban, S (February 2010). "Fine Mapping of Pre-S Sequence Requirements for Hepatitis B Virus Large Envelope Protein-Mediated Receptor Interaction". Journal of Virology 84 (4): 1989–2000. doi:10.1128/JVI.01902-09. PMC 2812397. PMID 20007265.
- ^ Xia, YP; Yeh, CT, Ou, JH, Lai, MM (February 1992). "Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear transport as a protein complex". Journal of Virology 66 (2): 914–21. PMC 240792. PMID 1731113.
- ^ Lehmann E, Brueckner F, Cramer P (November 2007). "Molecular basis of RNA-dependent RNA polymerase II activity". Nature 450 (7168): 445–9. doi:10.1038/nature06290. PMID 18004386.
- ^ Filipovska J, Konarska MM (January 2000). "Specific HDV RNA-templated transcription by pol II in vitro". RNA 6 (1): 41–54. doi:10.1017/S1355838200991167. PMC 1369892. PMID 10668797.
- ^ Greco-Stewart, VS; Schissel, E, Pelchat, M (2009-03-30). "The hepatitis delta virus RNA genome interacts with the human RNA polymerases I and III". Virology 386 (1): 12–5. doi:10.1016/j.virol.2009.02.007. PMID 19246067.
- ^ Li, YJ; Macnaughton, T, Gao, L, Lai, MM (July 2006). "RNA-Templated Replication of Hepatitis Delta Virus: Genomic and Antigenomic RNAs Associate with Different Nuclear Bodies". Journal of Virology 80 (13): 6478–86. doi:10.1128/JVI.02650-05. PMC 1488965. PMID 16775335.
- ^ Branch, AD; Benenfeld, BJ, Baroudy, BM, Wells, FV, Gerin, JL, Robertson, HD (1989-02-03). "An ultraviolet-sensitive RNA structural element in a viroid-like domain of the hepatitis delta virus". Science 243 (4891): 649–52. doi:10.1126/science.2492676. PMID 2492676.
- ^ Wu, HN; Lin, YJ, Lin, FP, Makino, S, Chang, MF, Lai, MM (March 1989). "Human hepatitis delta virus RNA subfragments contain an autocleavage activity". Proceedings of the National Academy of Sciences of the United States of America 86 (6): 1831–5. doi:10.1073/pnas.86.6.1831. PMC 286798. PMID 2648383.
- ^ a b Weiner, AJ; Choo, QL, Wang, KS, Govindarajan, S, Redeker, AG, Gerin, JL, Houghton, M (February 1988). "A single antigenomic open reading frame of the hepatitis delta virus encodes the epitope(s) of both hepatitis delta antigen polypeptides p24 delta and p27 delta". Journal of Virology 62 (2): 594–9. PMC 250573. PMID 2447291.
- ^ Jayan, GC; Casey, JL (December 2002). "Inhibition of Hepatitis Delta Virus RNA Editing by Short Inhibitory RNA-Mediated Knockdown of ADAR1 but Not ADAR2 Expression". Journal of Virology 76 (23): 12399–404. doi:10.1128/JVI.76.23.12399-12404.2002. PMC 136899. PMID 12414985.
- ^ Sato S, Cornillez-Ty C, Lazinski DW (August 2004). "By Inhibiting Replication, the Large Hepatitis Delta Antigen Can Indirectly Regulate Amber/W Editing and Its Own Expression". J. Virol. 78 (15): 8120–34. doi:10.1128/JVI.78.15.8120-8134.2004. PMC 446097. PMID 15254184.
- ^ Taylor, JM (2006). "Structure and replication of hepatitis delta virus RNA". Current topics in microbiology and immunology. Current Topics in Microbiology and Immunology 307: 1–23. doi:10.1007/3-540-29802-9_1. ISBN 978-3-540-29801-4. PMID 16903218.
- ^ Chang, MF; Chen, CJ, Chang, SC (February 1994). "Mutational analysis of delta antigen: effect on assembly and replication of hepatitis delta virus". Journal of Virology 68 (2): 646–53. PMC 236498. PMID 8289368.
- ^ Radjef N, Gordien E, Ivaniushina V et al. (March 2004). "Molecular Phylogenetic Analyses Indicate a Wide and Ancient Radiation of African Hepatitis Delta Virus, Suggesting a Deltavirus Genus of at Least Seven Major Clades". J. Virol. 78 (5): 2537–44. doi:10.1128/JVI.78.5.2537-2544.2004. PMC 369207. PMID 14963156.
- ^ Taylor JM (January 2006). "Hepatitis delta virus". Virology 344 (1): 71–6. doi:10.1016/j.virol.2005.09.033. PMID 16364738.
- ^ U.S. National Library of Medicine "Delta Agent (hepatitis D)"
- ^ Tayor, J. M. (2009). Desk Encyclopedia of Human and Medical Virology. Boston: Academic Press. p. 121. ISBN 0-12-375147-0.
- ^ Abbas, Z.; Khan, MA.; Salih, M.; Jafri, W. (2011). "Interferon alpha for chronic hepatitis D". In Abbas, Zaigham. Cochrane Database Syst Rev (12): CD006002. doi:10.1002/14651858.CD006002.pub2. PMID 22161394.
- ^ Pascarella S, Negro F (January 2011). "Hepatitis D virus: an update". Liver Int. 31 (1): 7–21. doi:10.1111/j.1478-3231.2010.02320.x. PMID 20880077.
- ^ Celik I, Karataylı E, Cevik E, et al. (December 2011). "Complete genome sequences and phylogenetic analysis of hepatitis delta viruses isolated from nine Turkish patients". Arch. Virol. 156 (12): 2215–20. doi:10.1007/s00705-011-1120-y. PMID 21984217.
- ^ Radjef, N.; Gordien, E.; Ivaniushina, V.; Gault, E.; Anaïs, P.; Drugan, T.; Trinchet, J. C; Roulot, D.; Tamby, M.; Milinkovitch, M. C.; Dény, P. (2004). "Molecular phylogenetic analyses indicate a wide and ancient radiation of African hepatitis delta virus, suggesting a deltavirus genus of at least seven major clades". J Virol 78 (5): 2537–44. doi:10.1128/JVI.78.5.2537-2544.2004. PMC 369207. PMID 14963156.
- ^ Alvarado-Mora, M. V.; Romano, C. M.; Gomes-Gouvêa, M. S.; Gutierrez, M. F.; Carrilho, F. J.; Pinho, J. R. (2011). "Dynamics of hepatitis D (delta) virus genotype 3 in the Amazon region of South America". Infect Genet Evol (Elsevier) 11 (6): 1462–8. doi:10.1016/j.meegid.2011.05.020. PMID 21645647.
- ^ Barros, L. M.; Gomes-Gouvêa, M. S.; Pinho, J. R.; Alvarado-Mora, M. V.; Dos Santos, A.; Mendes-Corrêa, M. C.; Caldas, A. J.; Sousa, M. T.; Santos, M. D.; Ferreira, A. S. (2011). "Hepatitis Delta virus genotype 8 infection in Northeast Brazil: inheritance from African slaves?". Virus Res 160 (1–2): 333–9. doi:10.1016/j.virusres.2011.07.006. PMID 21798297.
- ^ Le Gal, F.; Gault, E.; Ripault, M. P.; Serpaggi, J.; Trinchet, J. C.; Gordien, E.; Dény, P. (2006). "Eighth Major Clade for Hepatitis Delta Virus". Emerg Infect Dis 12 (9): 1447–50. doi:10.3201/eid1209.060112. PMC 3294742. PMID 17073101.
External links[edit]
- World Health Organization Fact sheet on Hepatitis D
- Viralzone: Deltavirus
- hepatitis-delta.org
- "Hepatitis delta virus". NCBI Taxonomy Browser. 12475.
This article incorporates text from the public domain Pfam and InterPro IPR002506


text:
Definition of outcrop in English:
Line breaks: out|cropPronunciation: /ˈaʊtkrɒp
- A rock formation that is visible on the surface: dramatic limestone outcropsMore example sentences
- Surrounding this lowlying area are 'horsts' of Palaeozoic rocks, and outcrops of Triassic conglomerates that drain into the basins of the Trent, Warwickshire Avon and the Severn.
- Xenoliths, which are pieces of wall rock, or xenocrysts, which are single mineral grains that originate from xenoliths, can commonly be recognized at outcrops of magmatic rocks.
- In western Thailand and eastern Myanmar, Mesozoic rocks are scattered and discontinuous, and outcrops of Palaeogene rocks are very rare.
( outcrops, outcropping, outcropped)
- Appear as an outcrop.More example sentences
- At the very entrance of the cave there is a mammoth rock outcropping with a huge footprint.
- From there a path twists its way through outcropping crags and tiny lochans to the summit, perched precariously on top of its own little crag.
- Back tire slurping and bouncing wildly, I kept going, finally slithering to a halt when I saw Jeff and Joe crouched under a rock outcropping.
- More example sentences
- In 2002, a dozen Moroccan soldiers planted a flag on Parsley Island, a small, uninhabited outcropping off the shore near Ceuta.
- My den was probably a cubbyhole in some hillock or outcropping of rock.
- I had my tripod set up on a rock outcropping in the direction of the wind.

subset: commoncrawl


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UK man charged with defacing Constable painting
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He was arrested at the gallery Friday after reports of an attack on "The Hay Wain."
The group Fathers 4 Justice, which campaigns on behalf of fathers denied contact with their children, said Manning was a "desperate dad" who had stuck a picture of his son on the painting.
The gallery said there was no permanent damage to Constable's 1821 rural scene, one of Britain's most famous artworks.
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"Nice mid-size set."
4.0 starson by reeltimePros: Decent picture. Very energy efficient. Great connectivity. 1080p (the info below is wrong). Super light and thin.
Cons: HDMI placed only left side. Audio is just so-so.
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Live as the Ingalls family in an awesome place. Despite we went in winter, seems a wonderful place to spend the summer, with canoes, little sail boats and an own island.
- Also Known As:
- Cabanas Puerto Arauco Argentina/Villa La Angostura, Patagonia
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#6 Family Hotel in Villa La Angostura
#21 Romantic Hotel in Villa La Angostura
- Official Description (provided by the hotel):
- Enjoy your stay with us at one of our six cabins located right on the shore of the lake, featuring a marvelous view to it and to the mountains. Delight yourself in our wonderful sand beaches.Puerto Arauco offers you a great contact with nature, a reunion with the simple things in life and the certainty of a real rest. Very careful of taking care of your privacy, we can make sure that you will enjoy your holidays either with your family or friends in an outstanding environment, with highly comfortable facilities and personalized service the four seasons of the year. ... more less


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Available colors:
With 3 rotors for big size watches plus storage space for 4 bracelet or strap watches and an extra compartment for straps.
Fully leather covered outside.
Leather and pure jacquard silk inside.
Silver coloured clasp.
Programmable, operates on batteries or with a 6 Volt DC adapter not included.
10 rotating programs.
Technical specification


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Tips for cutting clutter in your kitchen
Kitchen storage can quickly get filled up with cheap, single-purpose and/or disposable gadgets. Invest in versatile, durable (and better yet, sustainable) items that will last for years. Buying staples in bulk and storing them in your own reusable containers can also cut down on packaging clutter and use space more efficiently. Check out these local resources to help keep your kitchen clutter-free.
Plan ahead
Make use of what you have, even if you have limited space or supplies. This article titled "A super-efficient Japanese kitchen" offers tips and inspiration.
Stay ahead of the mess by cleaning your kitchen as you go.
Buy smart
Keep your kitchen ready with these essentials.
Find more ways to cut clutter while reducing your grocery bill.
Less waste, less mess
Rescue your food with a food triage box.
Get a little help from the pros
Watch this KATU segment for tips from Portland organizing expert MaryJo Monroe.
Use the "5S" method in your kitchen: sort, set in order, shine, standardize, and sustain.
The City does not endorse or assume responsibility for businesses, companies or organizations listed by the Be Resourceful program.


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Someone start it, already!
Someone start it, already!
Anything worth shooting is worth shooting twice. Bullets are cheap. Life is priceless.
With the exception of Fernando Bobblehead day, I refuse to give McDouche my money. And I thought I was cutting back with only 2 games last year...
I will be traveling to Anaheim, SF, and/or SDeezy to get my Dodgers fix. Might hit up CS Fullerton, USC and CS Long Beach and some minors as well. F- Frank McDouche !
Elbert with a rough outing. 10 batters so far, 6 walks. Seems like he's more likely headed towards being the next Greg Miller rather than the next Kershaw.
I will see you...in the next life
was gonna try to go check out training camp, but eff it.
will catch the Doyers when they come to SD. I hate that McCourt fella.
hoping Ethier has a better season, but not gonna hold my breath.
I'll be waiting for someone to give me tickets, because I can't imagine going a whole year without visiting Dodger stadium
I did that last year. Only one game and that was free tix and parking. I didnt even buy a soda. not a cent from me. Carpetbagger!
Reminds me of Matt Kemp in a way: superb athlete, raw, questionable defense. I think he takes over for Furcal next year at some point, since I'm not optimistic that Furcal gets his 600 plate appearances this year to make his 2012 option vest. I think he'll be an error machine when he comes up, but be fairly exciting as a hitter. Compared to past Dodgers, something like Offerman with a lot more speed. Or maybe Mariano Duncan with a better average?
I am hopeful for Elbert, if for no other reason that he was once a trade asset that the Dodgers help onto and now has fallen mightily. Like Greg Milller. I'm also disappointed in the lack of progress Josh Lindblom has made, really felt he was going to be a major piece of the Dodgers pitching staff but he's faltered lately too.
I will see you...in the next life


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Drawing on inspiration from the documentary Happy and the Oak Park Public […]
by John 'Lofty' Wiseman
Hello, I'm an eBook! ATTENTION: This item is an eBook. It can be read on iOS, Android, MAC and PC's with a supported eReader. It is not a physical book. eBooks are available via download immediately after you've checked out.
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For Any Climate, in Any Situation
Newly updated to reflect the latest in survival knowledge and technology, the internationally bestselling "SAS Survival Handbook" is the definitive resource for all campers, hikers, and outdoor adventurers. From basic campcraft and navigation to fear management and strategies for coping with any type of disaster, this complete course includes:
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First aid: A comprehensive course in emergency/wilderness medicine, including how to maximize survival in any climate or when injured.
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Watch YouTube Music Videos
This is a site where you can watch quality youtube music videos from your favorite artists. Enjoy the best YouTube Music Videos.
This is a site where you can watch quality youtube music videos from your favorite artists. Enjoy the best YouTube Music Videos.
Watch youtube music online from any artist or song that you want. Just type the name of the artist or the song (or both) in the search box and you will see youtube music videos for this search that you can actually watch in your pc.
| Song: Here's To Never Growing Up Artist: Avril Lavigne Album: Avril Lavigne [2013], Track 2 Released: 9 April 2013 Genre: Pop, Rock Length: 03:45 Label: Epic SongWriter(s): Avril Lavigne Martin Johnson Chad Kroeger David Hodges J. Kash Producer: Martin Johnson |
| Song: Let Me Go Artist: Avril Lavigne Album: Avril Lavigne Recorded: 2013 Released: 15 October 2013 Genre: Pop Rock, Soft Rock Length: 4:29 Label: Epic SongWriter(s): Avril Lavigne, Chad Kroeger, David Hodges Producer: Chad Kroeger |
| Song: Royals Artist: Lorde Album: Pure Heroine [2013], Track 3 - The Love Club - EP [2012], Track 2 Recorded: 2012 At Golden Age Studios, Auckland, New Zealand Released: 8 March 2013 Genre: Minimal, Art Pop Length: 3:09 - 3:21 (U.S. Video Mix) SongWriter(s): Ella Yelich O'Connor Joel Little Producer: Joel Little |
| Song: Just Give Me A Reason Artist: Pink Album: The Truth About Love Recorded: 2012 Released: February 26, 2013 Genre: Pop Length: 4:02 Label: RCA SongWriter(s): Pink, Jeff Bhasker, Nate Ruess Producer: Jeff Bhasker |
| Song: Heaven Artist: Depeche Mode Album: Delta Machine Recorded: 2012 Released: February 2013 Genre: Alternative, Electronic Length: 3:35 Label: Columbia Records (US), Sony Music (UK) SongWriter(s): Martin Gore Producer: Ben Hillier Lyrics: Depeche Mode - Heaven Lyrics |
| Song: I Knew You Were Trouble Artist: Taylor Swift Album: Red Released: November 27, 2012 Genre: Electropop, Pop Rock, Popstep Length: 3:40 Label: Big Machine SongWriter(s): Taylor Swift, Max Martin, Shellback Producer: Max Martin, Shellback |


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Welcome to the Muppet Central Forum!
You are viewing our forum as a guest. Join our free community to post topics and start private conversations. Please contact us if you need help with registration or your account login. -
"Muppets Most Wanted" Official Trailer
The official trailer for the new movie "Muppets Most Wanted" is now on-line! Watch it now and let us know your thoughts.
Fraggle Songs for My Acapella Group
Discussion in 'Fraggle Rock' started by Scooters Jacket, Sep 3, 2012.


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Arizona State Sun Devils Gear
Arizona State Sun Devils Home Office & School
(82 items)
Product ID: 1092322
Main Content
Order today, receive no later than
Tuesday, March 18th
Some limitations apply
$4.99 3-day shipping. Need it faster?
Have you done everything in your power to educate the people around you about the awesome experience of being an Arizona State fan? No? Show your co-workers, friends and family where your allegiance lies with this Sun Devils Team Logo mousepad featuring a bold Sun Devils logo accented by team-colored graphics. Now help make the Sun Devil Stadium the toughest place for opposing teams to visit by getting them to cheer their heads off!
- Made of neoprene
- Approximately 9" x 8"
- Team logo and colors
- Officially licensed collegiate product
Devils Fanatics also liked:
Special event items are produced by manufacturers only after the outcome of a game
or event. These are advanced sale items and will ship immediately after they are
received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items
are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite
number, and/or designs. Some options may be limited by league rules.


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Patrick: Boston victim of 'horrific attack'
UPDATED 6:10 PM EDT Apr 15, 2013Gov. Deval Patrick said the city is the victim of a "horrific attack."
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Sponsored Products
Enhanced Molding Capabilities
August 5, 2013 3:44 pm | by MDT Staff | Helix Medical | Product Releases | CommentsHelix Medical has announced additional capabilities in thin-wall injection molding utilizing implantable PEEK and silicone materials. Other specialized molding services include implantable thermoplastic & silicone specialty components, biopharmaceutical components, and fully-automated molding of tight tolerance silicone bellows.
LISTED UNDER: Molding | SiliconePatented Alloy Provides Breakthrough Parts Characteristics and One-Step Parts Processing
June 11, 2013 5:21 pm | by MDT Staff | Product Releases | CommentsBased on a scientific breakthrough developed at Caltech, the Department of Defense, and NASA, Liquidmetal Technologies has introduced an amorphous metal alloy that can be used in the production of highly complex parts via an efficient injection-molding process.
LISTED UNDER: Molding | MetalsPrecision Shape-Shifting Silicone Tubing Is a Reality
January 22, 2010 10:58 am | by Paul Mazelin | Articles | CommentsThe ability to manipulate tubing into different forms and with multiple lumens is a benefit to medical device designers. A newer technology, however, enables this metamorphosis to occur "on the fly" during the extrusion process.
LISTED UNDER: Extrusion | Silicon Molding | Silicon MoldingScientific Injection Molding: A Tool for Lean Manufacturing
December 2, 2009 4:26 am | by Frank Staples and Alpesh Patel | Helix Medical | Articles | CommentsInjection molding is a critical component fabrication technique in medical device manufacturing. Therefore, any method that can be employed to reduce costs associated with it is of much interest to device makers.
LISTED UNDER: Molding | Injection Molding | Silicon MoldingChallenges and Opportunities Realized During a Thermoset Tooling Transfer
December 2, 2009 4:25 am | by Tom Sloane | Articles | CommentsThe Project: Transfer tools from a closing thermoset molder to a new contract molder without sacrificing quality or capabilities. The Solution: Not only were the tools successfully transferred, but critical elements of the product were reevaluated and enhanced.
LISTED UNDER: Molding | Component Testing | Product DesignHandling a Three Molding Process Solution
August 28, 2009 12:02 pm | by Tobey Hayden | Articles | CommentsThe Project: Design a bed handle that will fit onto existing Joerns beds, increase patient comfort, and enhance caregiver safety.
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August 5, 2009 10:43 am | Product Releases | CommentsAdvanced technology for producing thin walled, large diameter, low durometer urethane extrusions is available. Commonly used in minimally invasive medical devices, such extrusions have been fraught with manufacturability challenges.
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December 5, 2008 7:03 am | Product Releases | CommentsThe Alliance of Plastics Processors (APP) is now accepting applications for the International Plastics Design Competition (IPDC), which will co-locate with NPE2009 on June 22-26 at Chicago's McCormick Place.
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December 5, 2008 7:03 am | Product Releases | CommentsMinnesota Rubber and Plastics (MR&P) has redesigned its website, which communicates the company's science-based approach comprising product design, manufacturing, process development, sourcing, quality systems, material sciences expertise, and program management.
LISTED UNDER: Molding | Product DesignMedical Device Molding: A Commitment, Not a Choice
November 10, 2008 6:52 am | by Brian Wright | Articles | CommentsBy Brian Wright With more and more jobs heading overseas, a growing number of molding companies have been changing their focus to medical device manufacturing. This can make sense; however, it is usually easier said than done.
LISTED UNDER: MoldingShort Run Molding for Long Term Success
September 10, 2008 8:32 am | Articles | CommentsMolding is a critical process in the manufacture of medical devices. However, long molding runs are not always the ideal option for the fabrication of components for a device. Short run molding provides numerous advantages to medical device designers that would not be otherwise realized.
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March 11, 2008 5:10 am | PolyOne Corp. | Product Releases | CommentsThe Geon HC product line will feature flexible injection molding and extrusion grade vinyl compounds with a wide range of durometers. These compounds are available from as low as 60 Shore A through nearly-rigid grades, and many have USP Class 6 and FDA regulatory status.
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November 5, 2007 9:11 am | Vesta, Inc. | Product Releases | CommentsThe company's extensive extrusion capabilities range from single-lumen tubing to coextrusions and multi-lumen tubing, with up to 28 lumens or more possible. Formulations range from clear to pigmented to radiopaque.
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LISTED UNDER: Molding | Silicon Molding | Silicon Molding


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ValerEQ 2.1
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Kerrigan hits milestone as Lancashire strike back
Simon Kerrigan claimed the 100th wicket of his first-class career as Lancashire fought back strongly against Somerset on the second day of their LV= County Championship Division One match at Aigburth.
The 21-year-old reached the landmark in his 31st game when he had Nick Compton leg before on the sweep for 22.
However, the Somerset batsman also had reason to celebrate, having become the first player to score a thousand championship runs when he reached 13.
By the close, though, the visitors had been bowled out for 149 in reply to Lancashire's first-innings total of 185 as this vital game for both sides continued to absorb the Liverpool crowd.
Kerrigan finished the day with 3-47 from 22 overs and was given good support by Glen Chapple, who returned 3-38, Ajmal Shahzad and Kyle Hogg.
In a tense afternoon session Kerrigan added the wicket of Craig Kieswetter, caught at backward point by Paul Horton for 16, to that of Compton, and Shahzad reduced Somerset to 89 for five next ball when he bowled James Hildreth for a patient 45.
After a 53-minute rain break, which included an early tea, Shahzad had Peter Trego caught at point for 17 and Kerrigan trapped Alfonso Thomas when the batsman attempted to lap the ball to leg.
Hogg claimed the key wicket of Jos Buttler and then bowled Gemaal Hussain as the home side finished the day on a high.
In the morning session Lancashire had lost their final five wickets for 56 runs, three of them to Thomas - who finished with 4-63.
Trego did not add to his first-day haul but made a significant contribution to his side's fortunes by pouching a slip catch off Steve Kirby to remove Andrea Agathangelou.
The South African-born batsman had looked one of his side's most polished and competent batsmen in making 24 off 59 balls and his first mistake - an edged forward push off Kirby - was his last. Kirby also had Kerrigan caught at slip and finished the innings with 2-40.
Despite posting only a modest total, the home side received an immediate boost when Chapple claimed two wickets in the four overs before lunch.
First the Lancashire skipper induced Arul Suppiah to play the fifth ball of the innings onto his own stumps and he then grabbed the prize wicket of Marcus Trescothick, who shaped to play Chapple to leg but succeeded only in edging to Stephen Moore in the gully.


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why is city weekly always promoting the ag-fays? don't you realize how sick they are? just google: homosexual diseases and click on the first link. then get you barf bag ready. parasites, tapeworms, anal-lingual. . . oh g-o-d no i'm going to puke.
please stop supporting these sickos.
Joe's Stab Shack really just sounds more unsafe then deserving of a boycot.


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Most Recent Articles In Fashion Scoops
Most Recent Articles In Fashion Scoops- 'Brave Miss World' Debuts in Paris
- Lanvin Touts History on Relaunched Web Site
- Moncler Moving to Borsa Italiana's FTSE MIB Index
BIRD'S-EYE VIEW: Les Sources de Caudalie "vinotherapy" spa near Bordeaux, France, has tapped Maxime Simoëns to redecorate a suite. The one-bedroom accommodation perched on stilts, called L'Ile aux Oiseaux (or bird island, in English), will be inaugurated on Feb. 7 amid Château Smith Haut-Lafitte's vineyards. Simoëns' decor signatures include prints, bar codes and the contrast of matte and shiny finishes. The same suite was decorated by Maison Martin Margiela three years ago.


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FAQ • Contact us • Terms of service • Privacy Policy
Spanish for Healthcare Professionals, Vol. 1: Basic Program starts at the beginning, teaching you the alphabet, numbers, parts of the body and other basic vocabulary in Spanish. The course then moves on to useful expressions and essential vocabulary for nurses and lab techs. There's also a helpful section on grammar basics.
The goal of this healthy environment continuing education program is to inform nurses, pharmacists and physician... More Info
Gannett Education is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation Accredited status does not imply endorsement by the provider or ANCC of any commercial products displayed in conjunction with this activity. Unless stated above, the planners and authors of this course have declared no real or perceived conflicts of interest that relate to this educational activity. Gannett Education guarantees this educational activity is free from bias. Please see CE Course Instructions to learn how to earn CE credit for this module. This course completion will be electronically reported to CE Broker as required per Florida Statute 456.025(7). Click here to view your CE Broker transcript and check the status of your CE requirements with a FREE 7-day CE Broker trial subscription. It may take up to 24 hours for the course to appear on your CE Broker transcript.


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The University is hosting the 2nd Annual Partnerships Celebration at Mission Bay on Thursday to recognize exemplary partnerships between San Francisco communities and UCSF.
Latest News
October 26, 2010
UCSF School of Pharmacy Dean Mary Anne Koda-Kimble updated the campus community on recent developments, including leadership changes, budget challenges, industry partnerships and plans for future development.
October 25, 2010
Open Enrollment, the annual opportunity for UC employees to make certain changes to their health and welfare plans, begins October 25 and continues through November 23.
October 25, 2010
The University of California today launched the Center for Health Quality and Innovation to promote key innovations across campuses, including several UCSF programs, to further enhance its delivery of patient care.
October 19, 2010
UCSF employees can learn more about proposed changes to retirement benefits at two upcoming town hall meetings on October 22 and 25.
October 04, 2010
UCSF health policy expert Janet Coffman addresses some of the reasons why California is ahead of other states and the benefits of being first in health care reform.
September 30, 2010
UCSF will provide free flu shots to all employees, students and volunteers with UCSF identification at drop-in clinics from Monday, Oct. 4 to Monday, Nov. 1, 2010.
September 24, 2010
The U.S. Department of Justice declined to consent to the University of California's motion to intervene in Sherley v. Sebelius, the case regarding federal funding for human embryonic stem cell (hESC) research, on which UC had made a motion to the U.S. Federal Court of Appeals on Sept. 20.
September 17, 2010
UCSF has launched a new, online tool that helps shed light on the University's research strengths and connects faculty to their colleagues.
September 07, 2010
UCSF is launching a Facebook fan page and a page focusing on the upcoming "Stand Up to Cancer" national telecast on September 10 to raise the visibility of the health sciences university.


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Topic: Deshaun Thomas
All Content
Final Four: Will Kentucky and Kansas emerge victorious? (+video)
The NCAA Final Four takes place Saturday evening in New Orleans. Louisville plays Kentucky, followed by Kansas and Ohio State. Kentucky and Kansas are favored to win. Both Final Four games will be televised by CBS.


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The Senior Men are heading to the 2nd round of the FIBA Americas Championship with some strong wins, Cory Joseph has been playing incredibly, Marial Shayok has some visits lined up, Canada medals at the U18 Americas 3x3 and more in Canadian Content.
Is Steve Nash being used incorrectly by the Lakers?, a great story on Notre Dame's Natalie Achonwa, Robert Sacre talks cheering, Andrew Wiggins turns it out, Duane Notice, Marial Shayok and Matthew Atewe make the rounds, lots of CIS action all here
Steve Nash is practicing now and could be back this weekend, Allison McNeill steps down as SWNT head honcho, Khem Birch is back, Melvin Ejim earns player of the week in the Big 12, my story on Jimmy Dorsey for SLAMonline and more in Canadian Content.
Today we have lots of Senior Women's stuff, Wiggins and Lyles at the Nike Global Challenge, Marial Shayok, Anthony Pate, Windsor's NBLC team and more in Canadian Content ...
Today we serve you some Senior Women's National Team, Steve Nash, Cory and Kris Joseph plus a whole lot of CIA Bounce and Andrew Wiggins at the Peach Jam all right here in Canadian Content ...
We Have Steve Nash, Robert Sacre, Andrew Nicholson and Lots More in Today's Canadian Content.
We have the Senior Women, Cory Joseph, Nik Stauskas, an NCAA commit and more in Canadian Content.
We have the NBL Canada, Anthony Bennett, Andrew Wiggins and a lot more in today's Canadian Content.
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Maserati of Stevens Creek
4520 Stevens Creek Blvd
San Jose CA 95129
(998.15 miles away)
JN Exotics
720 Kapiolani BlvdDealership Reviews
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Ferrari and Maserati of Newport Beach
1000 W Coast Hwy, Newport Beach, CA 92663
(1002.38 miles away)
Ferrari of Washington
45235 Towlern Pl, Dulles, VA 20166
(1472.11 miles away)
Jaguar-Land Rover-Bentley Rolls Royce-Aston Martin-Maserati-Porsche of Naples
900 Tamiami Trl N, Naples, FL 34102
(1808.48 miles away)
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Dealers in Nearby Cities
Take a look at the entire new and used automobile stock of Rozet Maserati dealers at Autobytel.com Browse current and past-production vehicles for sale by manufacturer date, cost, gas mileage, or distance from your home. Discovering Maserati dealers in Rozet is not that difficult. Buying an automobile can be a big decision. A prudent shopper will conduct some thorough investigation. See the inventory Rozet Maserati dealers currently have on-hand.
Over the past few years, more and more people have decided to research vehicles on the Internet. To go out and visit a Maserati dealer Rozet represents quite an investment in time. Instead you can search literally thousands of cars for sale at Maserati dealers in Rozet in a fraction of the time at the Autobytel.com site. There is a ton of data on current cars and those that are out-of-production. You can compare multiple vehicles at once. Or find the invoice price of a new or used vehicle. This is just the tip of the iceberg. The Autobytel website is packed with additional information. View multiple facts and stats on an automobile including a summary on the many options and accessories. You can also check-out multiple photos of the interior and exterior. Pinpoint Rozet Maserati dealers that are near to your location in no time.
Any great Maserati dealer Rozet has much more to offer than new and used sales. Most reputable Rozet Maserati dealerships have a complete financing department that offers leases. There will be a massive amount of factory car parts on-hand at a Rozet Maserati dealer. Free maintenance is offered on some new car purchases. And most Maserati dealers in Rozet will service your automobile for free if covered. In the event that your vehicle breaks down and the warranty has already expired; you can get repairs done at various Rozet Maserati dealers. There are other assets offered by a Maserati dealer Rozet including a body shop and a certified pre-owned sales department.
Autobytel.com also has a nice and convenient system for rating Rozet Maserati dealerships. Knowing the reputation of a business may save you heartache down the road. After all would you really buy a car from a Rozet Maserati dealer if they had nothing but negative reviews. Since you have a few different choices of Maserati dealers in Rozet, it is important to arm yourself with as much information as possible so you do not make the wrong decision.


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Tuesday, February 22, 2005
OK, I had myself a nice three-day weekend. I headed out of town and really tried to stay away from the computer for as long as possible! Of course, I had to try to do my taxes in there too, but I guess that has to be done!
Today also starts my American Idol Thoughts. Those of you who have been reading this site for over a year know that I enjoy American Idol. I believe that it should be required viewing for schools, at least through middle school. I think it shows that music and singing can be considered cool! Anyway, what I will do is write a few brief thoughts about how I thought each singer performed and then quickly rank how I think they did, therefore showing the two that I think should be eliminated. I hope you enjoy this feature as I will be doing this each time there are performances. Last night, the 12 boys/men sang and America will vote out two of them on Wednesday. Tonight, 12 girls/women will sing and two of them will also be eliminated based on America's vote, on Wednesday.
Anyway, I did work on a couple of projects over the weekend that will help me with future projects. However, for today, I am just going to provide you with a number of links and other thoughts that have been running through my head. OK, I am not going to bore you with all of the messed-up thoughts running through my head. I will confine it to, well, anything else.
But if, by chance, you have missed any of the divisional fantasy perspectives, check them out here. Tomorrow, I will be posting the National League East hitters.
Part 1 - American League Central Hitters
Part 2 - American League East Hitters
Part 3 - American League West Hitters
Part 4 - National League Central Hitters
Part 5 - National League East HittersAgain, if you have any questions or comments on anything, please e-mail me.
Here are just a few other sites that I noticed over the past few days:
Lets start with some Twins articles in the local media. Trib article on Joe Nathan by Lavelle E. Neal. Another Neal article discusses how excited Joe Mauer is to play again. Neal also discusses the few openings in the Twins pitching staff. The Pioneer Press's Jason Williams had a Q&A with Ron Gardenhire. Twins players expect to be asked about steroids.
Khalid El-Amin is playing in Turkey this year and still wants to play in the NBA. The former Minneapolis North star who went on to win a National title at U Conn wants another shot after a half-season with the Bulls a couple of years ago.
According to Aaron Gleeman's site on Friday, the Sports Illustrated swimsuit issue is out. OK, I did know that before reading it on his site. However, he pointed out that Mallory Snyder is one of the models featured. She was one of the housemates on The Real World: Paris. I wonder what ever happened with her and "Ace." Aaron mentioned that other Real World people have made their marks elsewhere (besides Trishelle). He didn't mention Kyle Brandt who was a member of The Real World: Chicago. He plays Phillip Kiriakis on Days of our Lives.
Looks like SethSpeaks favorite NBA player will soon be traded. Rumor has it that Devean George, Vlade Divac and Caron Butler will go to the Utah Jazz in exchange for power forward Carlos Boozer. The trade really seems to be good for both teams.
MLB.com ranks the Top 10 Twins in terms of fantasy baseball value. As would be expected, Johan Santana is the highest ranked, but who are the next nine?
Last week, The Baseball Savant took a deeper look at the steroid issue by arguing an article by Will Carroll for The Yes Network.
The Savant also continues his team previews by looking at the Kansas City Royals.
My sister and I hit another Sunday afternoon matinee this past weekend. We decided to go to Hitch, the comedy/romantic comedy starring Will Smith. I have to admit that I thought the movie was incredible. Not only was it funny, but for some reason (and not to sound over-corndoggish, but...) it was like the movie was speaking to me. I won't get into a review of it, but it is one of the better movies, particularly better comedies that I have seen in a long time! Kevin James was also great in his role as the shy, uncertain Albert.
Oh, and Eva Mendes is a given if I ever develop my Top 10 Hottest Actresses list. I know I talked about her a lot when I wrote about her small role in Stuck on You. But yeah, she was great as the object of Hitch's affection.
Seriously though, Will Smith is my hero! What an incredible life he has had. Really, I don't think that you could script a career as well. He started out by being highly educated and had the option of going to MIT for college. Turned that down and became a famous rapper by deciding to keep rap fun and refusing to get into the name-calling, excessive swearing that we see and have seen in much rap. By keeping his lyrics light, he was able to gain access to a wider variety of demographic (as well as winning a couple of Grammys). That helped The Fresh Prince of Bel-Air become widely popular. From there, he continued his rapping, but he also began doing bigger and bigger movies. He has shown great range in his movies from comedian, to action, to drama and everything.
Hey, the Twins officially started training camp yesterday when the pitchers and catchers reported to Ft. Myers. The Twins are the last team to get their players to camp, but most of the players live in Ft. Myers year round or show up early anyway ready to play.
Have I mentioned how excited I am about the 2005 Twins yet???
It was All-Star weekend in the NBA this weekend. The sophomores, a team that included Lebron James, Carmelo Anthony and Dwayne Wade beat the Rookie team. Steve Nash won the Skills competition (to no one's surprise). Quentin Richardson got engaged to Brandy this year, and he won the 3-point shoot out! My man, Josh Smith won the dunk contest with three consecutive 50s! That shouldn't be a surprise to anyone who watches SportsCenter and seen Smith in highlights frequently. Amare Stoudemire put on a show with the help of Steve Nash who "threw" him one alley-oops pass off of his head, after Stoudemire threw it hard off the backboard. Nash also flipped a soccer-style back pass for another alley-oop. And Allen Iverson won the MVP as the East beat the West in the All-Star game itself.
I am an incredibly slow reader, but I am currently reading a book called The Overnights. It was recently written by Jeffrey Victor Dorle. Mr. Dorle was born and raised in St. Paul, MN, but moved to Arizona. This is his very first published book. Like I said, I am a slow reader. With the work on the website, trying to have a personal life, and work, I am trying to read for about 45 minutes or an hour each night. But this is a VERY interesting, suspenseful book that although I'm just half-way through it, has me wondering which direction it is going to go next. Check out this site, and be sure to buy the book here if you enjoy a good, suspenseful mystery!
Stick and Ball Guy takes a deeper look at the Twins bullpen, one of the most exciting facets of this year's squad.
MSN announces their Top 10 Road Trips. I have been to just three of them, so I have a lot of catching up to do. I have been to the Mall of America, Disney World and the French Quarter.
The Timberwolves appear in two of the 10 Stories to follow in the NBA's second half. First involves their coaching vacancy after the season and where Flip Saunders will end up. The second simply involves how the team expected to contend will respond after a first half that barely had them at .500.
It is now Season 4 of American Idol. So far, winners Kelly Clarkson, Ruben Studdard and Fantassia Barrino have all been very successful. But so have Clay Aiken, Josh Gracin, Diana Degarmo and other contestants. Like Independent sports leagues, I love the concept of this show; giving people who wouldn't otherwise a chance to make it big.
There are a number of changes this year in the format of the show. Many were seen in previous weeks. The main one this year is that there will be six mean and six women in the final competition. Right now, there are 12 men and 12 women still in the competition. Last night, the 12 men each sang one song. America was asked to vote for their favorite. Tonight, 12 women will each sing one song. America will again vote for their favorite. On Wednesday, the two men and the two women who receive the fewest votes will be eliminated from the show. This will happen the next two weeks again to get down to the final 12.
Anyway, as I have in the past, I will critique each of the contestants. What I do is watch the show with a little notepad and jot down a couple of thoughts as I hear them sing. I will post those brief thoughts, and then I will conclude by ranking the performances. Obviously this is strictly one person's opinion, mine, and not everyone needs to agree with me. You will find that in some cases, I completely agree with the judges. You will also note that there are a few occasions when I completely disagree with them. So, let's get to it, but if you have any questions or comments, please be sure to e-mail me.
Nikko Smith - Part-Time Lover
Very strong voice. He sang high and low very well. To me, he sounded as good as Stevie Wonder did when he originally recorded it.
Scott Savol - You Are My Lady
Absolutely incredible vocally, as good as the original. He just looks and dresses really bad.
Anthony Federov - Hold on to the Night
He does have a strong voice in some ranges. But there are a number of weak spots, where he misses notes. He was a great story though (being told as a child that he may never even talk)
Bo Bice - Drift Away
He was far better when he was able to rock out on the chorus. It just didn't work for me when he was signing the verses.
Travis Tucker - My Shari Amor
Slow start, but once he started moving around, his voice got better, more in tune and stronger. Should have ended it before the "la-la-la's" though.
Constantine Maroulis - Kiss from the Rose
Horrible start on the verse, missed higher notes by far. But even his rocking was not good! Strange rendition of a great Seal song.
David Brown - Never Can Say Good Bye
He started out awful, just way out of tune, too low. Horrible song choice. From previous shows, he may have the most talent, but it didn't show last night!
Jared Yates - How Could I?
Excellent whiny voice, needed to clear his throat a little at times, but overall very good.
Anwar Robinson - Moon River
Looked confused, but really strong when he sang louder, just struggled with the low notes.
Judd Harris - Travelin' Band
At least he was fun and different. Certainly had a lot of charisma. He just looked like he was having fun. And, aside from all that, I thought he sang very well too.
Joseph Murena - How Am I Supposed to Live Without You?
The Kevin Millar/Barry Zito combo looking guy had an excellent voice. Hit both slow and fast notes. And at the end, he even said "thank you"!
Mario Vazquez - What Do I Do?
Excellent falsetto and energetic.
SethSpeaks Rankings
I will rank the performers from #1 (best) to #12 (worst). In doing that, I would be saying that my choices for who should be eliminated would be numbers 11 and 12.
1.) Nikko Smith - Simon said his performance would be forgotten after five or six more performances. I thought it was the best!
2.) Mario Vazquez -
3.) Scott Savol -
4.) Judd Harris
5.) Joseph Murena
6.) Anwar Robinson
7.) Jared Yates
8.) Anthony Federov
9.) Bo Bice
10.) David Brown
11.) Travis Tucker
12.) Constantine Maroulis - it was just that bad!
So, by that, I would have to guess that Travis Tucker and Constantine Maroulis will be the first two men eliminated. Check back tomorrow when I will analyze tonight's performances by the women. Again, if you have any thoughts, please e-mail me.
And on that note, I wish you a good day!. If you have any questions or comments on anything you have read above, please e-mail me.


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The Third Millenium: A History of the World A. D. 2000-3000Two scientists forecast, on the basis of present scientific knowledge as well as an understanding of historical, social, and political trends, the "history" of the next millenium, written as if looking back from the year 3000 |
What people are saying - Write a review
Review: The Third Millennium: A History of the World AD 2000-3000
User Review - GoodreadsFascinating predictions of the future from the days just before we had the Internet and we were still in a cold war with the USSR.. The prediction misses are as telling as the accurate predictions ...
Review: The Third Millennium: A History of the World AD 2000-3000
User Review - David - GoodreadsBack in 1985 when this book came out, it was at the very top of my must have list of books. I've read it countless times, with each reading giving me something new as my interests have evolved from ... Read full review
The World in the Year 2000 TwentySecond centuries | 83 |
Copyright | |
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Article: Interview: Brian Stableford, by Cheryl Morgan
... used in your current series comes from a book you wrote in collaboration with Dave Langford, The Third Millennium: A History of the World, ad 2000-3000. ...
www.strangehorizons.com/ 2001/ 20010312/ brian_stableford.shtml
The Future of Religion: Rise or Decline?
In their masterful The Third Millennium: a History of the World, AD 2000-3000, by the middle of the twenty-first century, the last great "religion," Marxism ...
www.wnrf.org/ cms/ decline.shtml
Langford Bibliography: Long Book List (ISBN)
1985; ISBN 0722153783; The Leaky Establishment; London, Sphere, paperback; ISBN 0283992115; The Third Millennium: A History of the World AD 2000-3000; ...
www.ansible.co.uk/ isbn.html
Reading List --- Humanities
The Third Millennium: A History of the World: AD 2000�3000 by Brian Stableford and John Langford. The Third Millennium is an incredible fantastical view of ...
www.trilithon.com/ pagesbooklists/ readingshumanities.html
David Langford
The Leaky Establishment (1984) The Third Millennium: A History of the World : Ad 2000-3000 (1985) (with Brian Stableford) Earthdoom (1987) (with John Grant) ...
www.fantasticfiction.co.uk/ l/ david-langford/
Boekenburg.nl - Een beknopt overzicht van het aanbod
19010, The third millennium. A History of the world:AD 2000-3000, Brian Stableford en David Langford, 1985, � 12,00. 22045, Trialogen , op de rand van het ...
www.boekenburg.nl/ prijslijst.php


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Soybean aphid season under way
Aphid populations below or even at the economic threshold do not cause yield loss, so treating before populations reach 250 aphids/plant only increases the probability of aphid resurgence. In addition, we have observed that many fields support a non-increasing, low population of aphids (e.g., less than 100 aphids/plant) through August. Treating these fields would be a waste of time and money.
Tank-mixing insecticides with glyphosate or other herbicides can be problematic because application methods for herbicides (e.g., lower pressures, large droplet-producing nozzles) are not optimal for good insecticide efficacy. Tank-mixing with fungicides can be effective because application methods for fungicides and insecticides require high water pressure for adequate penetration and coverage; however, only conduct this practice if soybean aphid thresholds are met.
Equipment Directory
Can you show us exactly how you calculated the 250 threshold? The exact formula on how it relates to control cost, market value, and yield potential? I bet you do not have this formula and just inventing stuff. Just show us the formula!
What's the matter, are computers and calculators and slide rules rigged to always calculate to 250 in Nebraska? Farmers are smart too, you know, even though they may not have advanced degrees. This 250 bullcrap does not pass the smell test.
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Halloween Costumes
Adult Costumes / Womens Costumes / Plus Size Halloween Costumes / Indian Maiden Adult Womens Plus Size Costume
Indian Maiden Adult Womens Plus Size Costume
Item# 07048390
Grab the peace pipe and head to the pow wow in this Indian Maiden adult womens plus size costume. The brown and tan, 100% polyester dress of this womens Indian costume features a tiered skirt with fringe details and printed bead work. A pair of fringe boot tops, a belt with buckle, choker and headpiece complete this plus size womens costume.
- The Indian Maiden adult womens plus size costume includes;
- Dress
- Boot tops
- Belt with buckle
- Choker
- Headpiece
- Hair ties and footwear not included
- Materials:
- 100% Polyester
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The Spirit Halloween Brightened MySpirit
Authentic Looking, Comfortable, Cute, Fits Well, Lots of Fun, Unique
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Detroit Tigers' Jhonny Peralta at the batting cage during practice at Comerica Park Tuesday, October 1, 2013. Kirthmon F. Dozier Detroit/Free Press / Detroit Free Press
OAKLAND, CALIF. — The Tigers could have done the right thing. Instead, they opted for the easy thing.
It�s no surprise that Jhonny Peralta made the 25-man playoff roster. But it�s disappointing, nonetheless. The opportunity was there for the Tigers to stand courageously alone as the Biogenesis scandal reached its next chapter, the admitted cheaters welcomed back and hailed as returning heroes.
While we�re at it, why not just make Biogenesis a partnering sponsor for tonight�s series opener between the Tigers and the Athletics?
Maybe Major League Baseball can get Biogenesis founder Anthony Bosch to throw out the ceremonial first syringe tonight at the O.co Coliseum?
The Tigers are perfectly willing to accept the accompanying baggage.
And there will be baggage. If Peralta stars against the Athletics, it becomes a full set of luggage for the Tigers specifically and MLB at large.
It�s funny listening to some of the excuse-makers rationalize that now isn�t the time for taking any strong moral stands because the Tigers� top priority should be putting themselves in the best position for winning the World Series.
But now is especially the time for a moral statement because there are far more eyes watching with the stakes and consequences building in equal proportion.
Peralta told reporters prior to the Tigers� workout Thursday that he pretty much understood he would make the playoff roster when the team had him report to Miami last week for the regular season�s final three games.
�I figured this would happen,� Peralta said. �I�m happy for the chance. All I can do is go out and do the best that I can do and see what happens.�
Manager Jim Leyland, meanwhile, said Andy Dirks and not Peralta would start in leftfield for Game 1 � in large part because of a far better track record against Bartolo Colon, the A�s starter and another admitted steroids cheater. Leyland said he would rely on his gut instincts when determining how to best use Peralta � even if that�s in increments. But Leyland admitted early in the week that he happily would trade better offense from his leftfielder for solid defense.
I credit Peralta for not shying away from the critical glare since his return last week. He�s not annoyingly pathetic like Alex Rodriguez. He knows he screwed up. He takes questions (he takes the same questions repeatedly from reporters) and certainly seems contrite.
But this has never been about a nice guy stumbling � as we all have at some point in our lives � taking his medicine, standing back up and attempting to move forward.
Baseball framed its entire PED prosecution and punishment template on the understanding that no individual � or no team �was bigger than the overreaching message to the larger audience that an honest, clean competition was paramount to all else.
I guess there was a hidden codicil that specified �unless it involves winning a World Series.�
It will be thrown in the Tigers� face that San Francisco opted against reinstating Melky Cabrera following his 50-game suspension a year ago for his involvement with Biogenesis. Cabrera was the Giants� best hitter and a favorite to win the National League batting title when he got nailed.
The Giants recovered from a 0-2 NLDS series deficit and eventually swept the Tigers out of the World Series.
What the Giants did should be thrown in the Tigers� face.
Colon also was implicated in the Biogenesis scandal. But MLB ruled he didn�t have to serve an additional suspension after his 50-game banishment a year ago.
Texas reinstated another of the Biogenesis group � outfielder Nelson Cruz � for its tiebreaker Monday night. And he got a standing ovation from the Texas crowd, serenading him with a chorus of �Cruuuuuuuuzzzz� when he first stepped to the plate. Common sense would suggest there would remain some hard feelings considering that the absence of Cruz�s run production in the middle of the Rangers� order contributed greatly to their struggles in September.
But this next chapter of the Biogenesis mess reaffirms what we already suspected � sports remain a morality of convenience.
Contact Drew Sharp: email@example.com. Follow him on Twitter @drewsharp.


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Need we say anymore? Who were the thugs that game? PS. We won them both Carlisle.
One more to show the contrast... CAR-LISLE!
Haven't wrestled since junior high. How many points was that takedown?
"I'm a moron for thinking the Browns could even sniff 10 wins in a division where the other three teams (two of whom almost always make the playoffs) made the post-season last year. Gyp Rosetti's thee God of football knowledge." - Brown Notes
You son of a bitch.
You must spread some Reputation around before giving it to Gameface again.
Did you say cake?
Bought a ticket for a runaway train
Like a madman laughing at the rain
Little out of touch, little insane
It's just easier than dealing with the pain.
Runaway train, never comin' back
Runaway train, tearin' up the track
Runaway train, burnin' in my veins
Being discussed on RealGM.
It would've been one thing if it was unprovoked, but I have a hard time feeling sad for Dirk after his blatant elbow to Hayward's face.


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Our Download of the Day today is CCleaner 3.00.1303.
CCleaner is a freeware system optimization, privacy and cleaning tool. It removes unused files from your system - allowing Windows to run faster and freeing up valuable hard disk space. It also cleans traces of your online activities such as your Internet history. Additionally it contains a fully featured registry cleaner. But the best part is that it's fast (normally taking less than a second to run) and contains NO Spyware or Adware! :)
Cleans the following:
� Internet Explorer
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� Windows - Recycle Bin, Recent Documents, Temporary files and Log files.
� Registry cleaner
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The latest version includes the following changes:
Changes in Version 3.00.1303
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- Added new environment variables: %SystemDirectory%, %SystemDirectory32% and %SystemDirectory64%.
- Improved Registry backup to address problems when saving values.
- Improved cleaning Windows Log Files for 64-bit OSs.
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The Ohio State University
The 2014-2015 Application for Special Scholarships administered through Student Financial Aid is now open! If you are selected to receive a Special Scholarship, you will be notified via your OSU Buckeye Link account.
Please click the following link to start or continue your application: 2014-2015 APPLICATION FOR SPECIAL SCHOLARSHIPS
Priority Application Date for 2014-2015: All Students: February 15, 2014
Because funds are limited, you will not necessarily receive funds from a scholarship for which you might otherwise be eligible. Every effort is made to distribute available scholarship funds to as many students as possible.


text:
Definition of focalize in English:
Line breaks: fo¦cal|izePronunciation: /ˈfəʊk(ə)lʌɪz
(also focalise)
- 1Focus (something), in particular:More example sentences
- Its effects are importantly focalized through Breeze.
- One of the biggest issues in bringing down the price has been working to focalize the laser using power efficiently.
- But now we are trying to focalise on our true identity.
- 1.1(In literary theory) provide an internal focus for (a text).More example sentences
- The story is, to use a term developed by the theorists of narrative Mieke Bal and Gérard Genette, focalized through her.
- Crucially, Crane chooses to focalize the departing train through hoboes: 'three men, still hungry on the tracks.'
- By focalising a narrative entirely through a character's perspective, there is no apparent mediating presence between story and narration.
- More example sentences
- But what she can do is force a shift in focalization - an even rarer feat in the context of this particular narrative.
- In Scarlet Sister Mary, shifts in focalization between omniscient and limited perspectives delve frequently into Mary's consciousness.
- The novel hides its subversive ideology behind Oshinica's focalization, masterfully using it to challenge the establishment.
Pronunciation: /-ˈzeɪʃ(ə)n/


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Kendall 60cc Irrigation Syringe
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1/9/2013 7:28 AMWas this review helpful? Yes / No (0/0)
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Wednesday, February 13, 2013
The ARTERY
Located at 346 Depot Street, in the River Arts District
The Asheville Area Arts Council invites you to SHARE THE LOVE.
SHARE THE LOVE is our Annual Membership and Friend-Raiser Party! Please join us, and bring a friend or two, Wednesday, February 13, 2013 from 7:30-10:00pm at The ARTERY, 346 Depot Street in the River Arts District. We will be celebrating our Members and launching our 2013 Membership Drive. Come and sip cocktail on us and enjoy a variety of Valentine's Day Treats!
Valentine's Day Raffle: WIN a Romantic Dinner for Two, at Asheville Hottest NEW restaurants Chestnut, and Isis Restaurant and Music Hall. Raffle tickets will be available for $5.00, Members get one ticket FREE!
Dress is Creative Casual
Membership is a personal donation, with a variety of benefits, that allows the Asheville Area Arts Council to continue to provide great programs and services like The ARTERY gallery, Kids Tixx, and grants and professional development for Buncombe County's artists.
Read the full article
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We've got your free sneak peek, along with deals available in XpressMail, our weekly email newsletter. (It's the best we can do without time travel.)
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In today's paper, find out why Jamestown man David Swain is able to walk free from Tortola and what the state is doing for future storms after Tropical Storm Irene.
Also, find out why it is important for fishermen and scientists to work together in the industry. Inside, find out how URI will be impacted by the new Board of Governors undocumented student policy.
All and more inside today's The Narragansett Times.
By JIM BARON Special to the Standard
When it comes to the two major political parties, IŌĆÖm pretty much a ŌĆ£plague on both your housesŌĆØ kind of guy.
SOUTH KINGSTOWN ŌĆō Although the South Kingstown schools received positive results on its K-8 literacy audit, the school committee held a work session Tuesday night to discuss how to utilize the evaluation to make the program even better for students.
The literary audit, in which each classroom is evaluated, provides an objective view on the work in South KingstownŌĆÖs schools. It provides suggested areas of focus for future improvement of the program over three to five years. The audit was done through a federal grant.
SOUTH KINGSTOWNŌĆöThe South Kingstown Chamber of Commerce sent out an email last Thursday to the five other local South County chambers and local businesses, notifying them of their official chamberŌĆÖs name change to the Southern Rhode Island Chamber of Commerce.ŌĆØ The Board of Directors for SKCC had voted unanimously for the change. The action has subsequently angered many of the surrounding chambers of commerce in South County, including Narragansett and Charlestown.
By KATHLEEN MCKIERNAN email@example.com
NARRAGANSETT ŌĆō New EnglandŌĆÖs fishing fleet may have to make room for Big Brother as a federally funded pilot program plans to use closed-circuit cameras on board to record the catch and replace human observers on fishing boats. The program has local fishermen up in arms over the extremes regulations have taken.
WEDNESDAY, OCTOBER 5 Boys soccer Burrillville at Exeter-West Greenwich, 3:30 p.m. South Kingstown at Hendricken, 6 p.m. Scituate at West Warwick, 3:30 p.m. Girls soccer Central Falls at Narragansett, 5 p.m Girls tennis Mount Hope at Exeter-West Greenwich, 3:30 p.m. Mount St. Charles at Prout, 3:30 p.m. Girls volleyball Coventry at South Kingstown, 6:30 p.m. West Warwick at Johnston, 5:30 p.m.
TUESDAY, OCTOBER 4 Field hockey North Kingstown at Burrillville, 3:45 p.m. East Greenwich at Moses Brown, 3:45 p.m. Boys soccer Narragansett vs. Toll Gate at Warwick City Park, 3:30 p.m. East Greenwich at Prout, 3:30 p.m. Girls soccer South Kingstown at Coventry, 3:30 p.m. Pilgrim at Chariho, 6:30 p.m. Johnston at West Warwick, 4 p.m. Girls tennis Narragansett at Coventry, 3:30 p.m. Hope at Exeter-West Greenwich, 4 p.m. North Kingstown at Moses Brown, 3:45 p.m. Westerly vs. South Kingstown at Broad Rock Middle School, 3:30 p.m.
MONDAY, OCTOBER 3 Boys cross country North Kingstown, South Kingstown at Chariho, 4 p.m. Middletown, Narragansett at Exeter-West Greenwich, 4 p.m. Westerly, West Warwick vs. Prout at Grills Reserve, 4 p.m. East Greenwich vs. Coventry vs. Cranston East vs. Cranston West at Roger Williams Park, 4 p.m. Girls cross country North Kingstown, South Kingstown at Chariho, 4 p.m. Middletown, Narragansett at Exeter-West Greenwich, 4 p.m. Westerly, West Warwick vs. Prout at Grills Reserve, 4 p.m.
This week's Rhode Island Sports Media high school football poll has just been released and there aren't a lot of surprises at the top. Undefeated La Salle was a unanimous choice for No. 1 and Cranston West received all 12 second-place votes. East Providence was third and Barrington and Hendricken tied for fourth. Locally, West Warwick was the only team to crack the Top 10, finishing ninth with 143 points. Chariho maintained its spot in the Top 20, moving up three spots to No. 14 and Exeter-West Greenwich also moved up a spot as the Knights are now ranked 17th.
By MARTHA SMITH Special to the Standard
NORTH KINGSTOWN ŌĆō Before Ken Shoener answers his cell phone, callers get to hear an energetic military band rendition of ŌĆ£Anchors Aweigh!ŌĆØ


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Turn tomato cages into feminine lanterns to provide interesting lighting in a room.
See how to incorporate Asian flair into this holiday season. Click for step-by-step instructions for an Asian-inspired ribbon box.
Browse new rooms from top designers.


text: OM Records is teaming up with Flavorpill and Naked Juice to present The Art of Yoga at the gorgeous San Francisco Museum of Modern Art on Saturday, September 8th, and we'd love for you to join us for this very special event! RSVP for your spot at the event, which features instructor Elise Lorimer, music by Omie J Boogie, free museum entry after the event and Naked® Pure Coconut Water. The first 100 people at the event score a free yoga mat, and a copy of the "Om Yoga" compilation CD. We promise that everyone will leave reinvigorated, replenished, and refreshed. Doors open at 8am, class starts at 8:30am. RSVP HERE |


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Richard Newcombe takes a look at Bitmap Animations in VB.NET. VB6 made extensive use of API's to load and initialize large quantities of smaller images. .NET has the GDI+ dynamic library, with a large selection of graphic classes and functions, which means that we no longer require API's to manipulate images.
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