text:
November 14, 2013
I am confident the boots will be waterproof and comfortable for walking in foothills and forest paths.
November 01, 2013
Isodry waterproofing has been good on other products so i am hopeful it will work on these shoes unlike some others returned recently to another supplier. 1size larger than normal shoe size needed
October 28, 2013
Have been on the look out for comfortable shoe with vibram sole. this fits the requirements exactly.
A good, comfortable shoe but i would agree with previous reviewers that buying a size too big is probably a sensible option - i found a size too big was a little bit loose but additional sole liners cured the problem. half sizes would be a good idea i think.
October 23, 2013
Very comfortable, breathable and waterproof a great bonus.
This does not affect your statutory rights
For full terms and conditions please see our Delivery & Returns policy


text:
Takes me back to the good old days when I was a MCNE and used to be flown out to Utah and San Jose at Novell's expense to attend Brainshare and NDA events...
Used to have 30 servers over 7 sites running Netware 5, 6.0 and 6.5, rock solid OS, hardly ever gave me any problems. Servers used to be up for years without being touched etc
I was just thinking about Novell today, wondering if I could recall the main commands of netware if needed.
it's 18 months since our last Netware box went off, a groupwise 8 server.
I hate Exchange.
Off the top of my head:-
Plus NWAdmin32 and ConSLOW1 for the admin and Client32 on the Win95 workstations
I agree Groupwise was a great product especially combined with Novell Instant Messenger, and also BorderManager as the firewall
Still got several of the t-shirts, jumpers, laptop cases, suitcase from back in the day when companies had bottomless corporate entertainment budgets
Last edited by AJWhite1970; 16th July 2013 at 09:34 PM.
timesync (restart or reset)
Dam I wana build one up again for fun...
Another one who cut their teeth with Netware, brilliant server OS and Windows Server still hasn't caught up in some areas. Hmm, will have to visit the loft to see if I've still got the disks
Anyone who still likes Netware didn't use 6.0 at release.
My fav old Netware command:
Netware 6.0 worked (apart from the awful ds.nlm that shipped with it that tore holes in NDS if your timesync was off and the NSS module that made a mess of traditional file stores if you ran NSSMU on an existing volume....) but when Netware 6.5 was released it was a much more feature rich product, and I'm still aware of a couple of small businesses to this day that are happily running NW65SP8
I have a vauge recolection of something, but we probably were on SP2 or SP3 within hours of installign 6.0...
I do remember beign very annoyed to find our DLT7000 tapes despite being the same tape as DLT-VS80 wer formatted differently so we could not directly restoer the backup of our NW5 server to the new NW6 server... The file copy took hours.
We still miss Zenworks
I fully gave in to the dark side four years ago when I took this job after finishing migrating a large site from Netware to Windows. To this day I still miss Zenworks for workstation management, GPP on steroids...
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An Introduction to Austrian Economics
: Understand Economics, Understand Everything
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: The Untold History of Controlling the Masses Through the Manipulation of Unconscious Desires
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: From Virility to Sterility
The Obama Deception
: The Mask Comes Off
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: The Hidden History of U.S. Sponsored False Flag Terrorism in Europe
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: The Untold History of The Project for the New American Century
Article posted Nov 07 2010, 5:05 PM
Federal Judge Finds Warrantless Cell Phone Tracking Unconstitutional
by Catherine Crump, Speech, Privacy and Technology Project
In August, we
about a court decision from the federal court in the Eastern District of New York that
that law enforcement agents are constitutionally obligated to get a warrant based on probable cause before obtaining historical cell phone location information. And in September, we
about an opinion from the 3rd Circuit Court of Appeals holding that judges may order the government to get a warrant based on probable cause for historical cell phone location information. However, the 3rd Circuit also held that judges are not obligated to require probable cause, and cautioned that they should only require the government to meet this high standard on rare occasions. Now another court has joined the fray. In a
detailed opinion
(PDF) citing
documents obtained through litigation by the ACLU and Electronic Frontier Foundation
, Judge Stephen Smith of the Southern District of Texas held that �warrantless disclosure of cell site data violates the Fourth Amendment.�
A few aspects of the
(PDF) are worth noting:
The government�s application appears to request historical location information for whenever the phone was turned on, not just when calls were made.
According to Judge Smith, �the Government seeks continuous location data to track the target phone over a two month period, whether the phone was in active use or not.� This is notable because the cell tracking applications we have seen previously only sought location information for those moments when an individual actually made a phone call. The government is now asking for a great deal more information, and consequently its requests are now more invasive than we previously thought.
Cell phone tracking information is increasingly accurate.
The opinion devotes many pages to explaining the ways in which cell tracking information has grown more accurate over time. In fact, it is because of these �refinements in location-based technology� that Judge Smith concludes that requests for cell tracking information trigger the Fourth Amendment�s warrant requirement.
The Fourth Amendment requires the government to get a warrant and show probable cause to obtain historical cell tracking information.
The court reached this conclusion both because cell tracking reveals information about constitutionally protected spaces such as the home, and because the prolonged nature of such surveillance is very invasive. The court likened the records sought by the government to �a continuous reality TV show, exposing two months� worth of a person�s movements, activities, and associations in relentless detail.�
As we have
explained elsewhere
, the ACLU agrees with Judge Smith that the government should be required to obtain a warrant and show probable cause before obtaining cell tracking information. As powerful new technologies enhance the ability of government agents to track our every move, it becomes all the more important that the courts hold the government to a rigorous standard before the government can access such sensitive information.
Email This
Abby Martin To Piers Morgan: MSM Filled With Corporate Shills Who Continuously "War Monger & Fear Monger!"
Ridicule As A Weapon Against Tyrants
Snowden Used Cheap, 'Web Crawler' Software to Collect NSA Files
Lawyer Creates DUI Search 'Refusal Sign' To Place In Car For Floridians
Aggressive Drunk Attacks Cashier With Knife, Gets Taken Down By Brave Customers
911 'Truther' Matt Mills On Crashing The Super Bowl
VICE Meets Glenn Greenwald: Snowden's Journalist of Choice
Glenn Greenwald Responds To Obama's BIG Speech On NSA Reforms
Comments 1 - 3 of 3
Add Comment
Page 1 of 1
Posted: Nov 08 2010, 5:20 PM
Isn't it obvious they have trashed the constitution already?
We want our country and constitution back as people are finally starting to wake up around the world to the tyranny of the banksters.
We must continue to sue in our courts over any violation of our rights so if they want to take them away they will have to announce it in courts around the country. Stand up to tyranny like the TSA clowns, the IRS and the FED. Homeland security must be disbanned as they are nothing more than the Gestapo inforcing the will of the rich bastards looking to control us and our lives. Time to take back control of our government.
Posted: Nov 10 2010, 8:32 AM
if you don't want the Gov't tracking your cell phone then don't have a cell phone. you people are retarded. I just watched ( most of it ) Alex Jones "documentary" on the economy. Apparently he doesn't realize almost all of the information he presents we all learned in 8th grade history. Big surprise " EXTRA EXTRA READ ALL ABOUT IT!!!! Industrial leaders in the 20th century had a huge influence on the economy!!!! Holy Shit. The next thing you know we're gonna have "vaccines" and "evolution" and "the internet".
Posted: Jan 17 2013, 7:24 PM
I should be able to have a cell phone without big brother listening in and tracking me. Why should I have to change what I do when it's the government we should change. The idea is that it's criminal not ok for folks who don't want a cell phone it's bad for us all even if you don't own a cell device.
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text:
Nike Air Yeezy 2 - Red
confirmed for later this year, but not with the Yeezus album release.
click here for more pics
Tags: nike nike sportswear air yeezy 2 all red red yeezy 2 kanye west sneakers collab
(Source: iorx, via blkkkskkkhead)
Tags: nike nike air yeezy 2 yeezy 2 yeezy kanye west sneakers pure platinum
Galaxy Foams x Yeezy 2's
(via middlechildswag)
Tags: nike air yeezy 2 air foamposite one galaxy galaxy foamposite sneakers kanye west
(Source: eddpxwell, via fashionconnoisseurr)
Tags: nike nike air yeezy louis vuitton lv jasper bordeaux air jordan 7 kanye west sneakers
(via guessitsmylife)
Tags: nike air yeezy 2 blacked out sneakers kanye west hip hop
Nike Air Yeezy 2 - Third Colourway
looks like the Air Yeezy 2 is not done with its releases.
just confirmed is a third colourway that we're just gonna have to wait to see more of.
Related articles
Tags: Air Yeezy Nike Air Yeezy Kanye West nike air yeezy 2 third colourway sneakers collab hip hop
Nike Air Yeezy II - Black/Solar Red
a look at the Black/Solar Red colourway of the upcoming Yeezy II.
tonal Black uppers with a Solar Red lining on a glow in the dark sole.
clean hard hitting sneaker.
while these are confirmed to release June 9th, check with your local spot to see if they're getting them.
Tags: Nike Air Yeezy Nike Kanye West air yeezy ii black/solar red sneakers hip hop collab june 9th
Nike Air Yeezy 2
some new pics of the Yeezy 2 coming from the official unveiling.
nice shoe with a ton of hype.
using lots of premium materials and prints on the upper with a glow in the dark sole.
some interesting Ancient Egyptian accents and those lace tips look great.
click here for more pics, and get ready for the June 9th release
Tags: Nike Air Yeezy Yeezy 2 Glow-in-the-Dark Ancient Egypt air yeezy 2 kanye west hip hop sneakers collab Kanye West june 9th
new pics of the Wolf Grey Yeezy 2, along with a look at the sketches.
really liking the reptile skin uppers and of course the glow in the dark sole.
click here for more pics, and stay tuned for more info on the June release
Tags: Nike Air Yeezy Kanye West Glow in the Dark Nike air yeezy 2 wolf grey sneakers collab kanye west x nike hip hop
Nike Air Yeezy 2 - Reschedule
the Yeezy 2 has been officially rescheduled for June of this year.
I'm actually pretty glad that the Yeezy 2 is coming out in June so I can be out of school and line up for these.
not exactly sure of the exact date yet, but stay tuned for that.
Tags: Nike Air Yeezy Yeezy 2 Kanye West air yeezy 2 sneakers reschedule june 2012 collab hype
based out of Toronto sneakers and men's style sneaker reviews at: fudgetackerTV Tweets by @fudgetacker


text:
Dinner service begins at 5pm nightly Happy Hour 4pm-7pm nightly in the bar/lounge area For reservations, please call: (702) 617-7075 For parties of 10 or more, please call (702) 617-6800 Resort Casual Dress Code VIEW MENU
The Prime Choice Steakhouse Hank's Fine Steaks & Martinis is one of the best steakhouses in Las Vegas and was recently honored with the coveted AAA Four Diamond Award. Why? Our menu features only the finest quality meats, with USDA Prime dry-aged beef, an excellent selection of the freshest seafood, creative sides and comfortingly decadent desserts. Our steaks start with the best cuts of meat, get seasoned simply, then cooked to perfection and delivered to your table perfectly charred and bursting with flavor. Whether you like your steak on or off the bone, we can accommodate your request. Or may we suggest our incredible Chateuabriand for two? Slideshow
A Mid-Century Modern Retreat Hank's doesn't just provide the very best steak in Las Vegas, its modern interpretation of classic mid-century décor also embodies the elegance and romance of a vintage night out on the town. From the moment you walk in, you'll feel as if you were transported to a time when going out to dinner was still treated like a special, unforgettable event. Well known as the top steakhouse in Henderson, Hank's Fine Steaks & Martinis offers an incredible selection of steaks, seafood, martinis and ambience that never fails to impress. Call now for reservations.


text:
Craftmade Contractors Select Contractor's Select Energy Star Ceiling Fan
Save 10% on ALL Craftmade Lighting and Door Chimes!
Enter coupon code CRAFT10 for fantastic savings!
Offer Ends 3/31/2014
Technical Specs
Amperage | 0.5 |
Base Color | Nickel |
Blade Pitch | 12 |
Blade Span | 42, 52 |
Blades Included | No |
Blades Sold Separately | Yes |
Bulb Base | Candelabra (E12), Medium (E26) |
Bulb Type | Compact Fluorescent, Incandescent |
CFM (High) | 7680 |
Collection | Contractor's Select |
Controller Included | No |
Downrod(s) Included | Yes |
Energy Efficiency (CFM / Watt) | 96 |
Energy Star | Yes |
Fan Control Type | Pull Chain |
Fan Type | Hanging |
Finish Application | Brushed |
Flush Mounting | No |
Height | 11, 12.5 |
Includes Remote | No |
Installation Available | Yes |
Light Kit Compatible | Yes |
Light Kit Included | No |
Manufacturer Warranty | 30 Year Limited |
Motor | AC Induction |
Motor Size | 153 x 12 |
Number of Blades | 5 |
Reversible Motor | Yes |
RPM (High) | 210 |
RPM (Low) | 78 |
RPM (Medium) | 120 |
Speeds | 3 |
Style | Transitional |
Suggested Room Fit | Bedroom |
Theme | Traditional |
Wattage | 80 |
Watts Per Bulb | 69 |
Width | 42 |
Configure your Contractor's Select Energy Star Ceiling Fan
Get It Installed more info ▼
When you order installation services from Installations Direct, a certified service provider in your community will contact you within 24 hours to make an appointment for your installation.
The service provider will install the new fixture and haul away the old fixture and any excess installation-related materials.
Finish configuring above to see price
Please finish configuring above
This product has additional required/recommended options. To configure, add to your cart.
Fan Blades Required
Down Rods Recommended
Contractor's Select Energy Star Ceiling Fan
Simple and practical, the Contractor's Select fan impresses with style and function.
- Standard 153 x 12, 3 Speed Reversible Motor
- Blade Sweep Options: 42" and 52" (Blades are NOT included)
- Two Downrods Supplied, 2" and 4"
- 30 Year Limited Warranty
- Five Custom Blades matched to exact weight
- Universal Remote Adaptable - Optional
- Light Kit Adaptable
- Additional Blade Selections in 42" Size Available
- Energy Star Qualified
Popular combinations (see Product Multimedia):
- Aged Bronze / Vintage Madera Gilded Motor with 52" Contractor's Design Rosewood Blades
- Aged Bronze Motor with 52" Contractor's Design Dark Oak Blades
- Aged Bronze / Vintage Madera Motor with 52" Contractor's Design Walnut Blades
- Brushed Nickel Motor with 52" Contractor's Design Brushed Nickel Blades
- Antique White Distressed Motor with 52" Contractor's Design Antique White Blades
Customize your fan:
- Blade options: Works with Type 5 Blades
- Light kit options: Works with Bowl Kits, Complete Light Kits, or Customized Fitter Light Kits.
Measurements (see Product Multimedia for accompanying line art)
- A. Ceiling to Bottom of Light Kit with 2" Downrod: 11.0"
- A. Ceiling to Bottom of Light Kit with 4" Downrod: 12.5"
- B. Ceiling to Fan Blades 2" Downrod: 8.5"
- B. Ceiling to Fan Blades 4" Downrod: 10.0"
- C. Fan Width: 11.0"
- D. Canopy Width: 5.125"
- E. Motor Housing Height: 3.5"
Additional Craftmade Links
- View Manufacturer Warranty
- Shop All Craftmade Products
- Shop All Craftmade Custom Blade Options Collection Products
Our SKU: Contractors Select
This product is listed under the following manufacturer number(s):
Aged Bronze - CS52AGVM*
Aged Bronze / Vintage Madera - CS52AWD*
Antique White Distressed - CS52BN
Brushed Nickel - CS52OBG*
Oiled Bronze Guilded - CS52W*
*Denotes a finish or option that has been discontinued
5 Questions from the Community
Are blades included in this version - blades are not showing as an "additional requirement"
can this fan be a flush mount fan?
Which wall control and hand-held can I use?
How can I order 52" blades for the Contractor's Select fan? The only choice given is the 42" which is too small.
Does this fan require special electrical wiring?
Craftmade Custom Blade Options Collection
Other Products In The Craftmade Custom Blade Options Collection
Craftmade Contractors Design
Traditional Energy Star Ceiling Fan with Custom Blade Options
$71.06$57.86(1) -
Craftmade CD Unipack 201
Ceiling Fan with Included Bowl Light Kit and Custom Blade Options
$127.50$59.70(4) -
Craftmade Mia
Tuscan Indoor Ceiling Fan with Bowl Light Kit and Custom Blade Options$187.20(5)
Craftmade Contemporary Flushmount
Five Blade Modern Ceiling Fan with Custom Blade Options$108.00(10)
Craftmade CD Unipack 202
Ceiling Fan with Included Bowl Light Kit and Custom Blade Options
Warranty Info
Craftmade warrants against defects in materials or workmanship for a minimum of TWO (2) YEARS from date of purchase for use, and agrees to repair or, at our option, replace a defective unit without charge.
IMPORTANT: This Warranty does not cover damage resulting from accident, misuse or abuse, lack of reasonable care (as listed on the instructions), the affixing of any attachment not provided with the product, alteration of any attachments factory installed, loss of parts or subjecting the fixture to any but the specified electrical service.
This warranty does not cover failure of bulbs due to accidents, abuse, misuse, vandalism, power surges, and acts of nature such as lightning damage or any bulbs purchased separately and installed by the consumer or any damage to the fixture caused by a separately purchased bulb.
No responsibility is assumed for any special incidental or consequential damages. Damages occurring during transit are not covered by this warranty.
To obtain warranty service, mail sales receipt as proof of purchase-date, and a brief explanation of the nature of the defect, to P.O. Box 1037, Coppell, TX 75019. You will receive, by mail, a Return Goods Authorization number issued by Craftmade, and returned freight prepaid.


text:
Fresh52 Farmer's Market
What's fresh? A farmers' market that sells locally grown produce, pastries and handmade crafts every Sunday. What's fresher? Helping that market celebrate amid live entertainment, kids' games and more.
Fresh52 is a lively, friendly, open air farmers and artisan market where neighbors and friends come together to celebrate their community. Every Sunday morning the market features choice vendors with pesticide free seasonal produce, freshly baked goods, gourmet olive oils, salsas, spices, sauces, nuts, handmade modern craft, artisans & more!
When: Sunday, Sept. 25, 2011
Where: 9480 S. Eastern Ave.
Cost: Free
Age limit: All ages
Categories: Community, Henderson
Event posted May 11, 2011
Last updated May 25, 2011
Join the Discussion:
Check this out for a full explanation of our conversion to the LiveFyre commenting system and instructions on how to sign up for an account.
Editor's Picks
- Word UP! Poetry & Music
- The Freakin' Frog
- Pub Quiz
- Shakespeare's Grille & Pub | time TBA
- Greatest Party on Earth
- 1 Oak | 10:30 p.m.
- Pac-12 Men's Basketball Tournament
- MGM Grand Garden Arena
- Whisk(e)y Wednesday
- Andre's French Restaurant
- Painting Women: Works from the Museum of Fine Arts, Boston
- The Bellagio Gallery of Fine Art
- Noche Azul Latin Thursdays at Blue Martini
- Blue Martini | 22:00:00
- Sander van Doorn
- Marquee | 22:00:00
- Vegas Nocturne
- Rose. Rabbit. Lie. | 20:00:00
- The Tom Green Show
- Vinyl
- Lema
- Marquee
- Pac-12 Men's Basketball Tournament
- MGM Grand Garden Arena
- McMullan's St. Patrick's Day
- McMullan's Irish Pub
- O'Sheas St. Patrick's Day Weekend
- O'Sheas
- GBDC Season Finale Party
- Ghostbar | time TBA
- Andrew Dice Clay
- Hard Rock Hotel & Casino
- Green Lantern
- XS | 10 p.m.
- NASCAR Weekend
- Las Vegas Motor Speedway
- Captain Morgan's Locals Appreciation Night at Gilley's
- Gilley's BBQ
- Raiding the Rock Vault
- LVH - Las Vegas Hotel
- The Tom Green Show
- Vinyl


text:
Main Content
This item ships within one business day.
Order as many items as you like with our $4.99 flat rate shipping.
Need it faster?
At home, baseball games are always on your television. Not just because you're a raving Nats fan, but because you're hoping that your baby's first words will either be "safe" or "batter up". Your family doesn't have a choice but to live the life of a serious baseball buff, so get your littlest one ready for years of nonstop D.C. enthusiasm with this New Era reversible National beanie! One side features a light blue cuff with an embroidered team name on the front and an allover print of the team's logo, mascot and script city name on the top, while the other side boasts the same solid light blue color and a W logo printed on the front. Don't children make baseball stuff look so gosh darn cute?
- 100% Cotton fabric
- One size fits most
- Imported
- Officially licensed Nationals knit beanie
Nationals Customers also liked:
Special event items are produced by manufacturers only after the outcome of a game
or event. These are advanced sale items and will ship immediately after they are
received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items
are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite
number, and/or designs. Some options may be limited by league rules.


text:
A Participant Shares | |
By sblankenship | 2 Jul 2009 |
I am convinced that my Turning Point facilitator was put into my life by God to show me the way of Jesus and the importance of His Word. I was inspired deeply. Turning Point is the most positive thing I have ever completed in my life.
I can't even begin to tell you how much better my life has become since I have become aware of the upward path to developing Christian character found in those precious verses contained in 2 Peter 1:3-11. Just being able to see those eight Christian traits in black and white helped me to apply them in my everyday life. The Word of God being alive in me-mind, body and soul-is a direct result of Turning Point.
I am so grateful for the opportunity to have taken Turning Point and so blessed to have learned how to apply what I've learned in my life. I guess that I can sum up where I am in life with a scripture. It is Proverbs 21:21. It says, "Anyone who wants to be godly and loving finds life, success and honor."(NIRV) Thank you, Father God, for the miracles that you have worked in my life! I have my family back in my life as a direct result of the life changes I've made with the encouragement I received from Turning Point. I have dealt with my life-controlling problem and am clean and sober. I have quit smoking cigarettes. I have stopped cursing. I have changed who I am. I may not be who I want to be. I may not be who I could be. But I thank Father God every day for not being who I used to be. I am truly a work in progress. So to answer the question of where am I in life... I'm in a much better place. In closing, I am a firm believer and a living example of Philippians 4:13, I can do all things through Christ who strengthens me.
I thank Turning Point for showing me the intensity of the Word of the Lord and the love of Jesus Christ. Turning Point has saturated my heart with the most beautiful thing in this world, the Word of God.


text:
Herpes simplex virus
Herpes simplex virus | |
TEM micrograph of a herpes simplex virus | |
Virus classification | |
Group: | Group I (dsDNA) |
Order: | Herpesvirales |
Family: | Herpesviridae |
Subfamily: | Alphaherpesvirinae |
Genus: | Simplexvirus |
Species | |
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the herpesvirus family, Herpesviridae, that infect humans.[1] Both HSV-1 (which produces most cold sores) and HSV-2 (which produces most genital herpes) are ubiquitous and contagious. They can be spread when an infected person is producing and shedding the virus. Herpes simplex can be spread through contact with saliva, such as sharing drinks.
Symptoms of herpes simplex virus infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals.[1] Lesions heal with a scab characteristic of herpetic disease. Sometimes, the viruses cause very mild or atypical symptoms during outbreaks. However, as neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons. After the initial or primary infection, some infected people experience sporadic episodes of viral reactivation or outbreaks. In an outbreak, the virus in a nerve cell becomes active and is transported via the neuron's axon to the skin, where virus replication and shedding occur and cause new sores.[2]
HSV-1 and -2 are transmitted by contact with an infected area of the skin during re-activations of the virus. Although less likely, the herpes viruses can be transmitted during latency.[citation needed] Transmission is likely to occur during symptomatic re-activation of the virus that causes visible and typical skin sores. Asymptomatic reactivation means that the virus causes atypical, subtle or hard to notice symptoms that are not identified as an active herpes infection. Daily genital swab samples show that HSV-2 is found in a median of 12-28% of days among those who have had an outbreak and 10% of days among those suffering from asymptomatic infection, with many of these episodes occurring without visible outbreak ("subclinical shedding").[3] For HSV-2, subclinical shedding may account for most of the transmission, and one study found that infection occurred after a median of 40 sex acts.[3] Atypical symptoms are often attributed to other causes such as a yeast infection.[4][5] HSV-1 is often acquired orally during childhood. It may also be sexually transmitted, including contact with saliva, such as kissing and mouth-to-genital contact (oral sex).[6] HSV-2 is primarily a sexually transmitted infection but rates of HSV-1 genital infections are increasing.[4]
Both viruses may also be transmitted vertically during childbirth, although the real risk is very low.[7] The risk of infection is minimal if the mother has no symptoms or exposed blisters during delivery. The risk is considerable when the mother gets the virus for the first time during late pregnancy.[8]
Herpes simplex viruses can affect areas of skin exposed to contact with an infected person. An example of this is herpetic whitlow which is a herpes infection on the fingers. This was a common affliction of dental surgeons prior to the routine use of gloves when conducting treatment on patients.
Viral structure[edit]
Animal herpes viruses all share some common properties. The structure of herpes viruses consists of a relatively large double-stranded, linear DNA genome encased within an icosahedral protein cage called the capsid, which is wrapped in a lipid bilayer called the envelope. The envelope is joined to the capsid by means of a tegument. This complete particle is known as the virion.[9] HSV-1 and HSV-2 each contain at least 74 genes (or open reading frames, ORFs) within their genomes,[10] although speculation over gene crowding allows as many as 84 unique protein coding genes by 94 putative ORFs.[11] These genes encode a variety of proteins involved in forming the capsid, tegument and envelope of the virus, as well as controlling the replication and infectivity of the virus. These genes and their functions are summarized in the table below.
The genomes of HSV-1 and HSV-2 are complex and contain two unique regions called the long unique region (UL) and the short unique region (US). Of the 74 known ORFs, UL contains 56 viral genes, whereas US contains only 12.[10] Transcription of HSV genes is catalyzed by RNA polymerase II of the infected host.[10] Immediate early genes, which encode proteins that regulate the expression of early and late viral genes, are the first to be expressed following infection. Early gene expression follows, to allow the synthesis of enzymes involved in DNA replication and the production of certain envelope glycoproteins. Expression of late genes occurs last; this group of genes predominantly encode proteins that form the virion particle.[10]
Five proteins from (UL) form the viral capsid; UL6, UL18, UL35, UL38 and the major capsid protein UL19.[9]
Cellular entry[edit]
Entry of HSV into the host cell involves interactions of several glycoproteins on the surface of the enveloped virus, with receptors on the surface of the host cell. The envelope covering the virus particle, when bound to specific receptors on the cell surface, will fuse with the host cell membrane and create an opening, or pore, through which the virus enters the host cell.
The sequential stages of HSV entry are analogous to those of other viruses. At first, complementary receptors on the virus and the cell surface bring the viral and cell membranes into proximity. In an intermediate state, the two membranes begin to merge, forming a hemifusion state. Finally, a stable entry pore is formed through which the viral envelope contents are introduced to the host cell.[12] In the case of a herpes virus, initial interactions occur when a viral envelope glycoprotein called glycoprotein C (gC) binds to a cell surface particle called heparan sulfate. A second glycoprotein, glycoprotein D (gD), binds specifically to at least one of three known entry receptors.[13] These include herpesvirus entry mediator (HVEM), nectin-1 and 3-O sulfated heparan sulfate. The receptor provides a strong, fixed attachment to the host cell. These interactions bring the membrane surfaces into mutual proximity and allow for other glycoproteins embedded in the viral envelope to interact with other cell surface molecules. Once bound to the HVEM, gD changes its conformation and interacts with viral glycoproteins H (gH) and L (gL), which form a complex. The interaction of these membrane proteins results in the hemifusion state. Afterward, gB interaction with the gH/gL complex creates an entry pore for the viral capsid.[12] Glycoprotein B interacts with glycosaminoglycans on the surface of the host cell.
Genetic inoculation[edit]
After the viral capsid enters the cellular cytoplasm, it is transported to the cell nucleus. Once attached to the nucleus at a nuclear entry pore, the capsid ejects its DNA contents via the capsid portal. The capsid portal is formed by twelve copies of portal protein, UL6, arranged as a ring; the proteins contain a leucine zipper sequence of amino acids which allow them to adhere to each other.[14] Each icosahedral capsid contains a single portal, located in one vertex.[15][16] The DNA exits the capsid in a single linear segment.[17]
Immune evasion[edit]
HSV evades the immune system through interference with MHC class I presentation of antigen on the cell surface. It achieves this through blockade of the transporter associated with antigen processing (TAP) induced by the secretion of ICP-47 by HSV.[18] In the host cell, TAP transports digested viral antigen epitopes from the cytosol to the endoplasmic reticulum, allowing these epitopes to be combined with MHC class I molecules and presented on the surface of the cell. Viral epitope presentation with MHC class I is a requirement for activation of cytotoxic T-lymphocytes (CTLs), the major effectors of the cell-mediated immune response against virally-infected cells. ICP-47 prevents initiation of a CTL-response against HSV, allowing the virus to survive for a protracted period in the host.
Following infection of a cell, a cascade of herpes virus proteins, called immediate-early, early, and late, are produced. Research using flow cytometry on another member of the herpes virus family, Kaposi's sarcoma-associated herpesvirus, indicates the possibility of an additional lytic stage, delayed-late.[19] These stages of lytic infection, particularly late lytic, are distinct from the latency stage. In the case of HSV-1, no protein products are detected during latency, whereas they are detected during the lytic cycle.
The early proteins transcribed are used in the regulation of genetic replication of the virus. On entering the cell, an α-TIF protein joins the viral particle and aids in immediate-early transcription. The virion host shutoff protein (VHS or UL41) is very important to viral replication.[20] This enzyme shuts off protein synthesis in the host, degrades host mRNA, helps in viral replication, and regulates gene expression of viral proteins. The viral genome immediately travels to the nucleus but the VHS protein remains in the cytoplasm.[21][22]
The late proteins are used in to form the capsid and the receptors on the surface of the virus. Packaging of the viral particles — including the genome, core and the capsid - occurs in the nucleus of the cell. Here, concatemers of the viral genome are separated by cleavage and are placed into pre-formed capsids. HSV-1 undergoes a process of primary and secondary envelopment. The primary envelope is acquired by budding into the inner nuclear membrane of the cell. This then fuses with the outer nuclear membrane releasing a naked capsid into the cytoplasm. The virus acquires its final envelope by budding into cytoplasmic vesicles.[23]
Latent infection[edit]
HSVs may persist in a quiescent but persistent form known as latent infection, notably in neural ganglia.[1] HSV-1 tends to reside in the trigeminal ganglia, while HSV-2 tends to reside in the sacral ganglia, but note that these are tendencies only, not fixed behavior. During such latent infection of a cell, HSVs express Latency Associated Transcript (LAT) RNA. LAT is known to regulate the host cell genome and interferes with natural cell death mechanisms. By maintaining the host cells, LAT expression preserves a reservoir of the virus, which allows subsequent, usually symptomatic, periodic recurrences or "outbreaks" characteristic of non-latency. Whether or not recurrences are noticeable (symptomatic), viral shedding occurs to produce further infections (usually in a new host, if any). A protein found in neurons may bind to herpes virus DNA and regulate latency. Herpes virus DNA contains a gene for a protein called ICP4, which is an important transactivator of genes associated with lytic infection in HSV-1.[24] Elements surrounding the gene for ICP4 bind a protein known as the human neuronal protein Neuronal Restrictive Silencing Factor (NRSF) or human Repressor Element Silencing Transcription Factor (REST). When bound to the viral DNA elements, histone deacetylation occurs atop the ICP4 gene sequence to prevent initiation of transcription from this gene, thereby preventing transcription of other viral genes involved in the lytic cycle.[24][25] Another HSV protein reverses the inhibition of ICP4 protein synthesis. ICP0 dissociates NRSF from the ICP4 gene and thus prevents silencing of the viral DNA.[26]
The virus can be reactivated by illnesses such as colds and influenza, eczema, emotional and physical stress, gastric upset, fatigue or injury, by menstruation and possibly exposure to bright sunlight.
Viral genome[edit]
The open reading frames (ORFs) of HSV-1[10][27] | |||||
Gene | Protein | Function/description | Gene | Protein | Function/description |
UL1 | Glycoprotein L [1] | Surface and membrane | UL38 | UL38; VP19C [2] | Capsid assembly and DNA maturation |
UL2 | UL2 [3] | Uracil-DNA glycosylase | UL39 | UL39 [4] | Ribonucleotide reductase (Large subunit) |
UL3 | UL3 [5] | unknown | UL40 | UL40 [6] | Ribonucleotide reductase (Small subunit) |
UL4 | UL4 [7] | unknown | UL41 | UL41; VHS [8] | Tegument protein; Virion host shutoff[20] |
UL5 | UL5 [9] | DNA replication | UL42 | UL42 [10] | DNA polymerase processivity factor |
UL6 | Portal protein UL-6 | Twelve of these proteins constitute the capsid portal ring through which DNA enters and exits the capsid.[14][15][16] | UL43 | UL43 [11] | Membrane protein |
UL7 | UL7 [12] | Virion maturation | UL44 | Glycoprotein C [13] | Surface and membrane |
UL8 | UL8 [14] | DNA helicase/primase complex-associated protein | UL45 | UL45 [15] | Membrane protein; C-type lectin[28] |
UL9 | UL9 [16] | Replication origin-binding protein | UL46 | VP11/12 [17] | Tegument proteins |
UL10 | Glycoprotein M [18] | Surface and membrane | UL47 | UL47; VP13/14 [19] | Tegument protein |
UL11 | UL11 [20] | virion exit and secondary envelopment | UL48 | VP16 (Alpha-TIF) [21] | Virion maturation; activate IE genes by interacting with the cellular transcription factors Oct-1 and HCF. Binds to the sequence 5'TAATGARAT3'. |
UL12 | UL12 [22] | Alkaline exonuclease | UL49 | UL49A [23] | Envelope protein |
UL13 | UL13 [24] | Serine-threonine protein kinase | UL50 | UL50 [25] | dUTP diphosphatase |
UL14 | UL14 [26] | Tegument protein | UL51 | UL51 [27] | Tegument protein |
UL15 | Terminase [28] | Processing and packaging of DNA | UL52 | UL52 [29] | DNA helicase/primase complex protein |
UL16 | UL16 [30] | Tegument protein | UL53 | Glycoprotein K [31] | Surface and membrane |
UL17 | UL17 [32] | Processing and packaging DNA | UL54 | IE63; ICP27 [33] | Transcriptional regulation |
UL18 | VP23 [34] | Capsid protein | UL55 | UL55 [35] | Unknown |
UL19 | VP5 [36] | Major capsid protein | UL56 | UL56 [37] | Unknown |
UL20 | UL20 [38] | Membrane protein | US1 | ICP22; IE68 [39] | Viral replication |
UL21 | UL21 [40] | Tegument protein[29] | US2 | US2 [41] | Unknown |
UL22 | Glycoprotein H [42] | Surface and membrane | US3 | US3 [43] | Serine/threonine-protein kinase |
UL23 | Thymidine kinase [44] | Peripheral to DNA replication | US4 | Glycoprotein G [45] | Surface and membrane |
UL24 | UL24 [46] | unknown | US5 | Glycoprotein J [47] | Surface and membrane |
UL25 | UL25 [48] | Processing and packaging DNA | US6 | Glycoprotein D [49] | Surface and membrane |
UL26 | P40; VP24; VP22A [50] | Capsid protein | US7 | Glycoprotein I [51] | Surface and membrane |
UL27 | Glycoprotein B [52] | Surface and membrane | US8 | Glycoprotein E [53] | Surface and membrane |
UL28 | ICP18.5 [54] | Processing and packaging DNA | US9 | US9 [55] | Tegument protein |
UL29 | UL29; ICP8 [56] | Major DNA-binding protein | US10 | US10 [57] | Capsid/Tegument protein |
UL30 | DNA polymerase [58] | DNA replication | US11 | US11; Vmw21 [59] | Binds DNA and RNA |
UL31 | UL31 [60] | Nuclear matrix protein | US12 | ICP47; IE12 [61] | Inhibits MHC class I pathway by preventing binding of antigen to TAP |
UL32 | UL32 [62] | Envelope glycoprotein | RS1 | ICP4; IE175 [63] | Major transcriptional activator. Essential for progression beyond the immediate-early phase of infection. IEG transcription repressor. |
UL33 | UL33 [64] | Processing and packaging DNA | ICP0 | ICP0; IE110; α0 [65] | E3 ubiquitin ligase that activates viral gene transcription by opposing chromatinization of the viral genome and counteracts intrinsic- and interferon-based antiviral responses.[30] |
UL34 | UL34 [66] | Inner nuclear membrane protein | LRP1 | LRP1 [67] | Latency-related protein |
UL35 | VP26 [68] | Capsid protein | LRP2 | LRP2 [69] | Latency-related protein |
UL36 | UL36 [70] | Large tegument protein | RL1 | RL1; ICP34.5 [71] | Neurovirulence factor. Antagonizes PKR by de-phosphorylating eIF4a. Binds to BECN1 and inactivates autophagy. |
UL37 | UL37 [72] | Capsid assembly | LAT | none [73] | Latency-associated transcript |
The Herpes simplex 1 genomes can be classified into six clades.[31] Four of these occur in East Africa with one clade in East Asian and another in Europe/North America. This suggests that this virus may have originated in East Africa. The most recent common ancestor of the Eurasian strains appears to have evolved ~60,000 years ago.[32] The East Asian HSV-1 isolates have an unusual pattern that is currently best explained by the two waves of migration responsible for the peopling of Japan.
The mutation rate has been estimated to be ~1.38×10−7 substitutions/site/year.[31]
Treatment and vaccine development[edit]
- For more details on treatment of herpes simplex virus, see Herpes simplex.
- For more details on vaccine research of herpes simplex virus, see Herpes simplex research.
Herpes viruses establish lifelong infections, and the virus cannot yet be eradicated from the body. Treatment usually involves general-purpose antiviral drugs that interfere with viral replication, reduce the physical severity of outbreak-associated lesions, and lower the chance of transmission to others. Studies of vulnerable patient populations have indicated that daily use of antivirals such as acyclovir[33] and valacyclovir can reduce reactivation rates.[5]
Connection between facial sores and Alzheimer's disease[edit]
In the presence of a certain gene variation (APOE-epsilon4 allele carriers), a possible link between HSV-1 (i.e., the virus that causes cold sores or oral herpes) and Alzheimer's disease was reported in 1979.[34] HSV-1 appears to be particularly damaging to the nervous system and increases one's risk of developing Alzheimer's disease. The virus interacts with the components and receptors of lipoproteins, which may lead to the development of Alzheimer's disease.[35] This research identifies HSVs as the pathogen most clearly linked to the establishment of Alzheimer's.[36] According to a study done in 1997, without the presence of the gene allele, HSV-1 does not appear to cause any neurological damage or increase the risk of Alzheimer's.[37] However, a more recent prospective study from 2008 with a cohort of several thousand people showed a high correlation between seropositivity for HSV and Alzheimer's disease, without direct correlation to the APOE-epsilon4 allele.[38] In 2011 Manchester University scientists showed that treating HSV1-infected cells with antiviral agents decreased the accumulation of β-amyloid and P-tau, and also decreased HSV-1 replication as expected.[39]
Multiplicity reactivation[edit]
Multiplicity reactivation (MR) is the process by which viral genomes containing inactivating damage interact within an infected cell to form a viable viral genome. MR was originally discovered with the bacterial virus bacteriophage T4, but was subsequently also found with pathogenic viruses including influenza virus, HIV-1, adenovirus simian virus 40, vaccinia virus, reovirus, poliovirus and herpes simplex virus.[40]
When HSV particles are exposed to doses of a DNA damaging agent that would be lethal in single infections, but are then allowed to undergo multiple infection (i.e. two or more viruses per host cell), MR is observed. Enhanced survival of HSV-1 due to MR occurs upon exposure to different DNA damaging agents, including methyl methanesulfonate,[41] trimethylpsoralen (which causes inter-strand DNA cross-links),[42][43] and UV light.[44] After treatment of genetically marked HSV with trimethylpsoralen, recombination between the marked viruses increases, suggesting that trimethylpsoralen damages stimulate recombination.[42] MR of HSV appears to partially depend on the host cell recombinational repair machinery since skin fibroblast cells defective in a component of this machinery (i.e. cells from Bloom's syndrome patients) are deficient in MR.[44] These observations suggest that MR in HSV infections involves genetic recombination between damaged viral genomes resulting in production of viable progeny viruses. HSV-1, upon infecting host cells, induces inflammation and oxidative stress.[45] Thus it appears that the HSV genome may be subjected to oxidative DNA damage during infection, and that MR may enhance viral survival and virulence under these conditions.
Use as an anti-cancer agent[edit]
Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic (cancer killing) ability.[46] Interim overall survival data from Amgen's phase 3 trial of a genetically-attenuated herpes virus suggests efficacy against melanoma.[47]
Use in neuronal connection tracing[edit]
Herpes simplex virus is also used as a transneuronal tracer defining connections among neurons by virtue of traversing synapses[48]
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External links[edit]
- Genital Herpes - Public Health Agency of Canada
- Herpes simplex: Host viral protein interactions: A database of HSV-1 interacting host proteins
- 3D macromolecular structures of the Herpes simplex virus archived in the EM Data Bank(EMDB)


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Survey of London Monograph 7: East Acton Manor House
Philip Norman
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'Heraldic illustrations', Survey of London Monograph 7: East Acton Manor House (1921), pp. 8. URL: http://www.british-history.ac.uk/report.aspx?compid=117424 Date accessed: 10 March 2014. Add to my bookshelf
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1. Suckling.—Per pale gules and azure, 3 bucks tripping or.
2. Sutton.—Or, a lion vert, a quarter ermine, with a molet for difference.
3. Ashfield.—Sable, a fess engrailed between three fleur-de-lys argent.
4. Perryn.—Argent, on a cheveron azure, between three pears vert, three leopards' heads argent.
5. Vyner.—Azure, a bend or. On a chief argent, a saltire engrailed gules between two Cornish choughs.
6. Hamilton.—Quarterly 1 and 4 quarterly. 1 and 4 gules, three cinquefoils ermine (Hamilton). 2 and 3 argent, a lymphad with the sails furled, flagged gules (Arran). 2 and 3 argent, a man's heart gules ensigned with an imperial crown on a chief azure, three molets argent (Douglas) impaled, with azure a fleur-de-lys argent with a molet for difference (Digby).
7. Onslow.—Argent, a fess gules between six choughs.
8. Chichester, Earl of Donegal.—Quarterly, 1 and 4, checky or and gules, a chief vair (Chichester), 2 and 3, azure fretty argent (Itchingham).
9. Lady Conway.—Sable, on a bend between two cottises argent, a rose gules between two rings Sable (Conway), impaling Sable a woman cut off at the breasts, crined or (Hueriblock).
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Remanufactured Ink Cartridges for Your Epson Stylus Photo 2100 PrinterThe remanufactured Epson Stylus Photo 2100 ink-jet cartridges from LD Products are guaranteed to meet or exceed the print quality of the OEM Epson Stylus Photo 2100 inkjet cartridges. Your Stylus Photo 2100 printer has the unique option of letting you choose between Photo Black T034120 ink and Matte Black T034820 ink to optimize your printing on both glossy and matte paper. LD Products offers you the same choice in our bulk sets, so you can buy the bulk set you need, and still have the option to purchase the alternate black individually. Purchasing our remanufactured Epson Stylus Photo 2100 ink cartridges is an excellent way to save money without sacrificing quality. Our Epson Stylus Photo 2100 Remanufactured Ink Cartridges have a 'One Year 100% Quality Satisfaction Guarantee'. The use of our Ink for the Epson Stylus Photo 2100 does not void your printer's warranty. |
Save Even More [Click to find out how]One Year 100% Guarantee [read more]We carry a One year 100% Quality & Satisfaction guarantee on all our Refill Kits and Remanufactured or Compatible ink cartridges. If you are having difficulties installing your cartridge, or are dissatisfied for any reason please contact us at 888.321.2552 M-F 5am to 7pm, Sat&Sun 7am to 4pm PST to set up a replacement or return. Worried About Your Printer Warranty? |


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Wednesday, March 12, 2014
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A year-and-a-half after Tropical Storm Irene washed out much of Schoharie County, people there are still paying to rebuild. But as YNN's Maria Valvanis explains, now they'll be faced with another cost. The Biggert-Waters Reform Act of 2012 takes effect this year, increasing flood insurance nationwide and especially in high risk areas.
SCHOHARIE COUNTY, N.Y. -- "It's just more burden, more financial burden," said property owner Leslie Price.
The bills haven't stopped coming for the people whose homes and businesses were affected by Tropical Storm Irene.
Price said, "I've spent a lot of money and I continue to spend a lot of money and business in the village is down in general with only so many homes moved back in."
And now another cost. President Obama signed the Biggert-Waters Reform Act of 2012 into law last summer, meaning flood insurance costs could increase up to 25 percent for property owners nationwide.
"The rates are all set by FEMA, so unlike car insurance, there's no shopping the rate and going to other carriers. It's all one set rate by FEMA, by the government," said Todd Stewart of Hopmeier Evans Gage Insurance.
Matthew Avitabile, the Mayor of Middleburgh, said, "You're talking about another burden that people just can't afford. You can't ask people that we're just thrown out of their houses for all this extra money."
According to flood maps, many of those people that were thrown out of their homes by Irene, live in high risk areas, meaning they'll feel the increase even more.
"It certainly makes it more difficult to deal with recovery," said property owner James Bryant.
James Bryant is still working to get back into his Main Street office, which, along with his home, was flooded. He says any extra costs will make many people think twice about insurance.
Bryant said, "At some point, people are just going to take the risk and hope it really was a 500 year flood and not a ten year flood."
"I'll continue to be covered, as much as maybe I won't like the increase, you have to do it. You have to keep safe," said Price.
Insurance agents say people can expect to see the increase on their yearly renewal.


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Most of our Fine Art photographic prints are available in larger sizes. Just ask!
Mocha Chip's live music career is celebrated in the concert memorabilia available at Wolfgang's Vault. The Collection is divided into Mocha Chip Posters, Mocha Chip Photographs, Mocha Chip Apparel as well as other Mocha Chip memorabilia such as vintage tickets backstage passes and media like Rolling Stone magazines.


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Turn Based Strategy
Showing page 1 of 76.
TripleA Maps A collection of all maps and games made for the TripleA game engine.
49,024 weekly downloads -
Battle for Wesnoth Turn-based strategy game with a high fantasy theme
6,413 weekly downloads -
Open General Evolution of SSI Panzer General II
6,091 weekly downloads -
VASSAL Engine VASSAL is a game engine for creating electronic versions of traditional board and card games. It provides support for game piece rendering and interaction, and supports play by email or over a live connection.
3,770 weekly downloads -
DivFix++ DivFix++ is yours AVI video repair and preview software. It designed for repair and preview files which are on download from ed2k(emule), torrent, gnutella, ftp. web or any other source on the internet. It can repair AVI and DivX files (for now.)
3,345 weekly downloads -
Freeciv Freeciv is a free turn-based multiplayer strategy game, in which each player becomes the leader of a civilization, fighting to obtain the ultimate goal: to become (or subvert) the greatest civilization.
3,085 weekly downloads -
TripleA An online multiplayer turn based strategy game and board game engine.
3,005 weekly downloads -
NetHack NetHack is a popular single player dungeon exploration game that runs on a wide variety of computer systems.
1,649 weekly downloads -
FreeCol Colonize the New World.
1,533 weekly downloads -
Domination (Risk Board Game) Domination is a board game that is a bit like the well known game Risk
1,490 weekly downloads -
UFO:Alien Invasion It is the year 2084. You control a secret organisation charged with defending Earth from a brutal alien enemy. Build up your bases, prepare your team, and dive head-first into the fast and flowing turn-based combat.
989 weekly downloads -
FreeOrion 4X Space Strategy Game
1,084 weekly downloads -
Scid Scid is a chess database application (cross-platform, for Unix/Linux and Windows) with many search and database maintenance features.
1,043 weekly downloads -
Empire: Total War modding tools A GUI application for managing Empire: Total War pack files. Features: * adding, deleting, extracting, and replacing of files * changing between different pack types (boot/release/patch/movie)
850 weekly downloads -
Scorched 3D Scorched 3D incorporates a lively three dimensional landscape that includes animated jets, naval vessels, water, and even birds, in addition to detailed tanks and projectiles. Other enhancements include LAN and internet play and music.
717 weekly downloads -
Brutal Chess Brutal Chess features full 3D graphics, an advanced particle engine, and several different levels of intelligent AI, inspired by the once popular "Battle Chess" released by Interplay circa 1988.
1,196 weekly downloads -
Countryball World Play a turn-based strategy game with the funny countryballs!
2,050 weekly downloads -
MegaMek MegaMek is a networked Java clone of BattleTech, a turn-based sci-fi boardgame for 2+ players. Fight using giant robots, tanks, and/or infantry on a hex-based map.
541 weekly downloads -
Civilization IV Mods The home of Realism: Invictus mod for Civilization IV
547 weekly downloads -
Extended Greek Mod XGM is a modification for Rome - Total War
368 weekly downloads -
ChessX Chess Database and PGN viewer
314 weekly downloads -
free heroes2 engine Free implementation of Heroes of the Might and Magic II engine. SDL is used.
253 weekly downloads -
Race Into Space This is the official home of Race Into Space, the computer version of the Liftoff! board game by Fritz Bronner. It was developed by Strategic Visions and published by Interplay as a disk-based game in 1993 and a CD-ROM in 1994.
199 weekly downloads -
UnNetHack UnNetHack is a fork of Nethack. It is a roguelike, single-player role-playing game where the hero must venture through the depths of the Dungeon of Doom to retrieve the Amulet of Yendor.
161 weekly downloads -
The BUG Mod The BUG Mod (Beyond the Sword Unaltered Gameplay) is a mod for the popular TBS game Civilization IV: Beyond the Sword. This mod adds many interface enhancements that aid game play without modifying the rules or providing hidden information.
148 weekly downloads


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Budget Accommodation Europe France Biarritz
Biarritz is a city in the southwest of France, located along the Atlantic coastline in the region of Aquitaine.
From the Biarritz Travel Guide
The location of the hotel is ideal for the beach and town facilities. Rooms are quite small, and no air conditioning. Late bar across the road so can be noisy. However, hostess is extremely welcome and accommodating, and the rooms and hotel are spotless. Overall a great stay and value for money and I would stay again! Thanks! ... more
When we asked about assistance with information on the local surfing school and if they could call and make a reservation for us we were met with total disbelief and the very idea was unheard of. Since we were from another country our mobile phone did not work for local calls here. Breakfast was great and comes with the room. ... more
Myself & my boyfriend are flying into Biarritz on 12th May. We have 5days to spend between there & San Sebastian- We are thinking of heading straight to San Sebastian & than back to Biarritz for 15-17. If anyone has any suggestions of what to do & especially where to stay (at a reasonable price) I would ...
Biarritz this summer?
Hi,I am Swedish girl who is planning to work and live in Biarritz for the summer. I am looking for someone to share an appartment with. I am also grateful for any ideas anyone might have on how to find housing in Biarritz for the summer. ...
Greetings to All.I am going to Biarritz in october for a week,just wondering could anyone recomend a good restaurant or 3.thanks. ...
Biarritz Ja Biarritz er en fin by, skikkelig turistby da, med strender, barer, surfebutikker ...
Posted in Vive la France by katdom
We arrived in Biarritz to sunny weather around lunchtime. We met some Auzzies at the train ...
Posted in Where in the World... by bouffner
Bonza Biarritz Barrels; Bloody Brilliant!
Just got back from my third surf in beautiful Biarritz; and couldn't be happier. Except ...
Posted in Adventures and Challenges, My 18th Year by clancy_of_


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Live Updater prompted me to install this. It's still new on my W510, but the wifi, sleep and trackpad issues appear to be solved .
I didn't see this update on the Acer site for some reason. Strange, cuz 2.04 was on their site but never showed up in Live Updater.
OK, I just had the repeated-keys typed problem while typing this. Oh well, if that isn't fixed, it's not as annoying as the other problems.
Sent from my Windows 8 device using Board ExpressLast edited by pseudoware; 02-11-2013 at 03:20 PM.
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By ixtab1970 in forum WPCentral.com - Site News, Feedback, HelpReplies: 3Last Post: 06-21-2008, 02:21 PM


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Amniotic Fluid Activates the Nrf2/Keap1 Pathway to Repair an Epidermal Barrier Defect In Utero
Amniotic Fluid Activates the Nrf2/Keap1 Pathway to Repair an Epidermal Barrier Defect In Utero
Developmental Cell, Volume 23, Issue 6,
Pages 1238-1246,
Publication Date 11 December 2012
Copyright © 2012 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.devcel.2012.11.002
Aaron J. Huebner
Daisy Dai
Maria Morasso
Edward E. Schmidt
Matthias Schäfer
Sabine Werner
Dennis R. Roop
Department of Dermatology and Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, Denver, CO 80045, USA
Cell Biology, Stem Cells, and Development Graduate Program, University of Colorado, Denver, CO 80045, USA
Developmental Skin Biology Section, NIAMS, NIH, Bethesda, MD 20892, USA
Department of Immunology and Infectious Diseases, Montana State University, Bozeman, MT 59717, USA
Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH), 8093 Zurich, Switzerland
Corresponding author
► Nrf2-activating metabolites are present in late-stage amniotic fluid ► Sprr2d and Sprr2h are direct downstream targets of Nrf2 in the epidermis ► Blocking the Nrf2 pathway in the loricrin null mouse results in postnatal lethality ► Pharmacological activation of Nrf2 in utero rescues the delay in barrier formation
The loss of loricrin, a major component of the cornified envelope, results in a delay of epidermal barrier formation. Therefore, the living layers of the epidermis are aberrantly exposed to late-stage amniotic fluid, which may serve as the signal to upregulate genes that functionally compensate for the loss of loricrin. Consistent with this hypothesis, metabolomic studies revealed marked changes in amniotic fluid between E14.5 and E16.5 days postcoitum. In addition, we discovered that the Nrf2/Keap1 pathway detects these compositional changes and directly upregulates the expression of genes involved in the compensatory response, thus ensuring postnatal survival. In support of this finding, we demonstrate that genetically blocking the Nrf2 pathway abolishes the compensatory response and that preemptively activating Nrf2 pharmacologically rescues the delay in barrier formation in utero. Our findings reveal that the functions of Nrf2 and the composition of amniotic fluid have coevolved to ensure the formation of a functional barrier.


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Digital Photo Magazine, Only $4.99
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Biloxi Blues Information |
If you're in the mood for a musical or play, look no further than Biloxi Blues tickets. We've got the best seats for a matinee or evening show. Biloxi Blues proves that the magic of theatre is still alive and well, so get your tickets today. All of the theater tickets listed are guaranteed and are generally 10 to 20 percent cheaper than the competition. |


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(305) 234-0012
Brio Tuscan Grille is open today from 11:30am to 11pm.
- Friday to Saturday
- 11:30am - 11pm
- Sunday to Thursday
- 11:30am - 10pm
Located near Bloomingdale's in Suite E-380
Best Entrance: Near Bloomingdale's
BRIO invites you to gather with friends, family and co-workers to experience the flavors of Tuscany without leaving the country. Bringing the pleasures of the Tuscan country villa to Miami, our chef-inspired Tuscan recipes are sure to tempt your palate. At BRIO we believe that "to eat well is to live well." Buon Appetito!
See all things at The Falls®: Restaurants (order via wait staff)
Pairing Tip: Enjoy the Tuscan Grilled Pork Chops with an elegant glass of Sketchbook Pinot Noir.
brioitalian - 3/13/2014
What you can't talk about the rest of the week... Martini Talk. $5 Martini Wednesday [Where Legal - Times Vary]
brioitalian - 3/5/2014
Have a craving for something grilled?... Well you're in luck! Which item will you be ordering? 1. Grilled Mahi Mahi 2. Filetto Di Romano 3. Tuscan Grilled Pork Chops 4. Grilled Tilapia
brioitalian - 2/21/2014
brioitalian - 2/16/2014
Love is journey... Stay the course! Congratulations to Sandra, the second bonus feature and winner of a $75 Brio Gift Card! Sandra's Story: Chuck was the buff football player and I was the loud and crazy cheerleader. He had this secret crush on me all through high school but never acted on it. I never knew this. We both got married to other people had children and lived our lives. As fate would have it we both ended up divorced many years later. Through a random Facebook post due to a debate on a government issue I chimed in and posted Facebook and politics don't mix! We started talking on Facebook and again as fate will have it, it brought us together! We have been dating for 18 months now! We both feel like a couple of kids in love! Life is GOOD!
brioitalian - 2/14/2014
Don't be shellfish-share a bowl of our delicious Lobster Bisque tonight!
brioitalian - 3/4/2014
Feeling crabby? [Crab & Shrimp Cakes]
brioitalian - 2/27/2014
Peace. Love. Wine! Happy $5 Wine Thursday! [Where Legal | Times Vary]
brioitalian - 2/20/2014
Today we are celebrating you! Happy Random Acts of Kindness Day! Print your voucher for a free dessert here: http://ow.ly/tHHCI [TODAY ONLY - Monday, February 17, 2014]
brioitalian - 2/17/2014
This couple's story will give you a Valentine's Day smile! =) Aren't they just the cutest?! Congrats to Trudy our third winner of a $200 Brio Gift Card! Trudy's Story: 46 years ago a young and skinny intern admitted a dying patient to the Urology ward. I was the only nurse on duty that evening. As I watched and listened to him speak gently to this man and his wife I said to myself, "I wish my Dad had a doctor like him". We spoke briefly that evening and then he left my floor to admit another patient. He remembered me. We had our first date three days later. Got engaged four months later and will celebrate our 45th anniversary in May. I married a kind and compassionate and caring man who still practices medicine the same way. And, yes, we work together, too! How lucky I am that he saw me that fateful night, too!
brioitalian - 2/14/2014
Happy Employee Appreciation Day to each and every one of our team members! =)
brioitalian - 3/7/2014
Happy Employee Appreciation Day to Cindy Mathieson and her team. They have won lunch for up to ten at Brio! Cindy please send us a private Facebook message to claim your prize! Why Cindy said her team is the best: My colleagues are a fabulous team. We ensure that 100 kindergarten students get the best of us every day. We make sure that if a child didn't eat before they arrived at school, that they get breakfast before they have to start academic work. You can't do your best at learning if you are hungry. We work way beyond that final bell ring, often 2-3 hours after our students have gone home. If a child couldn't afford a field trip, we've paid for it out of our own pockets so that the child has the experience. Truly no child is left behind. I can't say enough about any of the teachers at my school, but the 5 other teachers in my department are top notch.
brioitalian - 3/7/2014
Employee Appreciation Day is tomorrow. Tell us why your team is the best and you could win lunch for up to ten! Post below and we'll randomly choose the winner tomorrow.
brioitalian - 3/6/2014
Brio, the hottest accessory on the red carpet at this year's Oscars... First we'd like to thank The Academy of Motion Picture Arts and Sciences/ The Oscars...
brioitalian - 3/2/2014
We had such a great day surprising people with Random Acts of Kindness! What are some R.A.K. ideas that can be done all year long? Pass it on! =)
brioitalian - 2/17/2014
We believe in variety. Dolchinos - Ask your server for this season's features.
brioitalian - 3/12/2014
Why do salmon swim upstream?... To get to Brio! Salmon Griglia Insalata - Only 400 Calories
brioitalian - 3/11/2014
It's what you've been looking forward to all week long...
brioitalian - 2/28/2014
What's your pick? The Shrimp Mediterranean off the Lighter Side of Tuscany menu with only 470 calories or the big, delicious and comforting Lasagna Bolognese Al Forno? =)
brioitalian - 2/19/2014
Who was your first great love? Did your first love turn into a great love story? We would love to hear about how your love story started and you could win a $200 Brio Gift Card! Share Your Love Story & Win Some Love: http://bit.ly/MYLQxf
brioitalian - 2/13/2014
How do you and your friends dip? 1. Just a little at a time... Gotta make it last. 2. Evenly so every one gets their fair share. 3. Dive right in! It's basically a game of Hungry Hungry Hippos!
brioitalian - 2/26/2014
What is your favorite Brio Bruschetta? Can't decided?... Bruschetta Quattro is a sampling of our four housemade Bruschettas! Problem solved!
brioitalian - 2/25/2014
Love across the miles! =) Congrats to Sarah on being a bonus winner of a $75 Brio Gift Card! Happy Valentine's Day! Sarah's Story: I moved to a new city in the 3rd grade, and Sean was one of the first people that I met in my new class. However, it was not until we were sophomores in college that we reconnected and started to become close friends. We were going to college in cities four hours apart, so the friendship grew gradually. For a while, we kept in touch through messages and little get-together when I was home for weekend visits. Meanwhile, I was also getting ready to study abroad in Barcelona for my spring semester. The night before I flew to Spain, Sean stopped by my house to say goodbye. He had bought me a movie, Back to the Future II, for us to watch together when I returned, and I thanked him. Secretly, I was hoping this meant that perhaps our friendship was growing into something more. Right before my flight the next day, I got a text message ending in "I'll miss you :)", and my hopes grew even more. To my surprise, Sean wrote me messages every single day in those four months that I was gone. When I came home we started to spend more time together, and it wasn't long until he told me flat out how he felt about me and we began dating. For a year and a half we made our long distance relationship work, and it was always worth it to see each other in the summer and as much as we could on the weekends. We've graduated and are living in the same city again, and now we're making plans for our future together. He is so incredibly smart, we make each other laugh, and I know that he would do anything for me. I love him endlessly.
brioitalian - 2/14/2014
Life is always full of surprise and stories to still be told! Are you as excited by Mary's story as we are? Congrats Mary for winning a $200 Brio Gift Card! Mary's Story: Little did I realize that a fleeting glance in a movie theater 52 years ago would have an impact on the rest of my life. You see, unbeknownst to me, the love of my life and I shared a moment in a movie theater in downtown Chicago eight years before we met again at work. As a boy and his friends exited a row, my family and I sat in their seats. I happened to sit in one boy's seat and found a wallet that had slipped out of his pocket. I turned to look for him, but he was gone. In the wallet was his high school ID and when I returned home I searched the phone book for his last name. I called and told him I had found his wallet and would send it to him. Fast forward, 30 years later, it happened again that I found another wallet, called the lady and returned it to her. As my my husband and I were talking about it, he told me that he lost a wallet when he was 16 in a downtown Chicago movie theater and he talked to a girl on the phone who found his wallet and mailed it to him. Meant to be together? We think so! Did your love story have an amazing start? Share your love story & win some love! Enter for a chance to win a $200 Brio Gift Card http://bit.ly/MYLQxf
brioitalian - 2/12/2014