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BAY73-4506 Probe Substrate Study
This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: January 31, 2011
Last updated: January 13, 2014
Last verified: January 2014
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In vitro studies have shown that regorafenib may have a clinically relevant inhibitory effect on substrates of CYP2C19, CYP3A4, CYP2C9 and CYP2C8. This CYP probe substrate study will be performed to evaluate the effect of regorafenib on the pharmacokinetics (PK) of CYP substrates and provide information about potential changes in exposure of these substrates when administered with regorafenib.
Condition | Intervention | Phase |
Neoplasms |
Drug: Regorafenib (Stivarga, BAY73-4506) + warfarin + omeprazole + midazolam Drug: Regorafenib (Stivarga, BAY73-4506) + rosiglitazone |
Phase 1 |
Study Type: | Interventional |
Study Design: | Allocation: Non-Randomized Endpoint Classification: Pharmacokinetics Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | A Phase I, Non-randomized Open-label Study to Evaluate the Effect of BAY73-4506 (Regorafenib) on Probe Substrates of CYP 2C9 (Warfarin), 2C19 (Omeprazole) and 3A4 (Midazolam) in a Cocktail Approach (Group A) and on a Probe Substrate of CYP 2C8 (Rosiglitazone, Group B) in Patients With Advanced Solid Tumors |
Resource links provided by NLM:
Drug Information available for:
Warfarin sodium
Midazolam hydrochloride
Omeprazole magnesium
Rosiglitazone Maleate
Esomeprazole Sodium
Esomeprazole magnesium
U.S. FDA Resources
Further study details as provided by Bayer:
Primary Outcome Measures:
- Pharmacokinetics of probe substrates (AUC, Cmax, etc.) [ Time Frame: Approximately 6 weeks ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Tumor Response evaluation measured by Response Evaluation Criteria in Solid Tumors (RECIST 1.1) [ Time Frame: Up to 3 years or longer if indicated ] [ Designated as safety issue: Yes ]
- Adverse event collection [ Time Frame: Up to 3 years or longer if indicated ] [ Designated as safety issue: Yes ]
Enrollment: | 40 |
Study Start Date: | August 2011 |
Estimated Study Completion Date: | October 2014 |
Estimated Primary Completion Date: | October 2014 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Arm 1 |
Drug: Regorafenib (Stivarga, BAY73-4506) + warfarin + omeprazole + midazolam
BAY73-4506 administered orally twice a day (bid) in a 21-day on / 7-day off schedule Group A: CYP 2C9 (warfarin), 2C19 (omeprazole) and 3A4 (midazolam) at Cycle 1
Experimental: Arm 2 |
Drug: Regorafenib (Stivarga, BAY73-4506) + rosiglitazone
BAY73-4506 administered orally twice a day (bid) in a 21-day on / 7-day off schedule Group B: CYP2C8 (rosiglitazone) at Cycle 1
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Histological or cytological documentation of confirmed advanced solid tumors. Subjects should have measurable or non-measurable disease according to RECIST
- Life Expectancy of at least 3 months
Adequate bone marrow, liver, and renal functions as assessed by the following laboratory requirements conducted within 14 days prior to the first study treatment:
- Hemoglobin ≥ 9.0 g/dL
- Absolute neutrophil count (ANC) ≥1,500/mm3
- Platelet count ≥ 100,000/ mm3
- Total bilirubin ≤ 1.5 times the upper limit of normal (ULN)
- Alkaline phosphatase ≤ 2 times ULN
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 x ULN (≤ 5.0 x ULN for subjects with cancer involving the liver)
- Serum creatinine ≤ 1.5 times ULN and glomerular filtration rate (GFR) ≥ 30 ml/min/1.73 m2, according to the MDRD (Modified Diet in Renal Disease) abbreviated formula
- Lipase ≤ 1.5 ULN
- International normalized ratio (INR) and partial thromboplastin time (PTT) ≤ 1.5 ULN
- Subjects who are therapeutically treated with warfarin, heparin or other anticoagulants are not eligible for study participation in Group A. Subjects who are therapeutically treated with warfarin, heparin or other anticoagulants, will be allowed to participate in Group B of the study provided they meet all eligibility criteria. Close monitoring of at least weekly evaluations will be performed until INR or PTT are stable by the local standard of care.
Exclusion Criteria:
- History of cardiac disease: Congestive heart failure (New York Heart Association, NYHA, Class III or IV) or active coronary artery disease (unstable angina [angina symptoms at rest] or new-onset angina [began within the last 3 months] or myocardial infarction within the past 6 months). Treatment with Type 1A or 3 anti-arrhythmics, such as Quinidine, Procainamide, Amiodarone, or Sotalol are not permitted. β-Blockers and digoxin are permitted.
- Uncontrolled hypertension (failure of diastolic blood pressure to fall to or below 90 mmHg or systolic blood pressure to fall to or below 140 mmHg with or without the use of antihypertensive drugs). At screening, subjects with history of hypertension should be on a stable anti-hypertensive treatment for at least 7 days prior to the first dose of study drug.
- Patients with known allergy to any of the study drug(s) to be administered, including known severe allergies, non-allergic drug reactions, or multiple drug allergies to any of the study drug(s) to be administered. This is also includes hypersensitivity to any of the compounds or excipients that will be administered to the study subject, specifically regorafenib, and warfarin, omeprazole and midazolam for subjects in Group A, or rosiglitazone for subjects in Group B.
- Subjects with evidence or history of disorders of coagulation
- Known history of HIV or positive screening test for HIV infection or active hepatitis B or C
- Subjects unable to swallow PO (per os) medications
- Active serious infection (> Grade 2 according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 4)
- Interstitial lung disease with ongoing signs and symptoms at the time of screening
- Autologous bone marrow transplant or stem cell rescue within 4 months prior to Day 1
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01287598
Canada, Alberta | |
Edmonton, Alberta, Canada, T6G 1Z2 | |
Canada, British Columbia | |
Vancouver, British Columbia, Canada, V5Z 4E6 | |
Canada, Ontario | |
Hamilton, Ontario, Canada, L8V 5C2 | |
Canada, Quebec | |
Montreal, Quebec, Canada, H3T 1E2 |
Sponsors and Collaborators
Study Director: | Bayer Study Director | Bayer |
More Information
Additional Information:
No publications provided
Keywords provided by Bayer:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 10, 2014
Additional Information:
No publications provided
Responsible Party: | Bayer |
ClinicalTrials.gov Identifier: | NCT01287598 History of Changes |
Other Study ID Numbers: | 12434 |
Study First Received: | January 31, 2011 |
Last Updated: | January 13, 2014 |
Health Authority: | Canada: Health Canada United States: Food and Drug Administration |
Keywords provided by Bayer:
Phase I Probe substrate target therapy |
small molecule neoplasms pharmacokinetics |
Additional relevant MeSH terms:
Neoplasms Midazolam Omeprazole Warfarin Rosiglitazone Adjuvants, Anesthesia Central Nervous System Agents Therapeutic Uses Pharmacologic Actions Anti-Anxiety Agents Tranquilizing Agents Central Nervous System Depressants Physiological Effects of Drugs Psychotropic Drugs |
Hypnotics and Sedatives Anesthetics, Intravenous Anesthetics, General Anesthetics GABA Modulators GABA Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Anti-Ulcer Agents Gastrointestinal Agents Enzyme Inhibitors Anticoagulants Hematologic Agents Hypoglycemic Agents |
ClinicalTrials.gov processed this record on March 10, 2014


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Published January 19, 2012, 11:30 PM
Holt: Office goodies test willpower
I'm convinced I'm physically incapable of resisting a cookie. Especially a Hornbacher's cookie. Chocolate chip, chocolate-dipped peanut butter, fudge-brownie, monster, snickerdoodle – it doesn't matter, they all make my mouth water. If they're there, I want one ... or three.By: Meredith Holt, INFORUM


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Patagonia Gloves |
Patagonia makes gloves for folks big and small. I like the Baby Pita Pocket Gloves mostly because of the name and also they are cute and tiny like most babies. But for full grown humans they offer all kinds of nifty gloves. Patagonia offers Synchilla Fleece gloves for adults as well as kids that match their awesome Synchilla Fleece. Also, in the Patagonia glove department are a few varieties of windproof gloves that come with and without fingers, as well as heavy and lightweight glove liners. This actually denotes the amount of protection the liners provide and not the type of gloves different boxers use. These kinds of semantics get confusing because gloves are used in cold weather and in boxing and so are the terms lightweight and heavyweight, apparently. The important thing about gloves is that hands stay warm. Patagonia gloves helps with that. It's like they attached several tiny sleeping bags together to keep your fingers warm. Unless we are talking about Patagonia Sun Gloves, then it's not at all like sleeping bags. Anyway, Patagonia gloves are like 190 times better than frostbite so it's wise if you wear them. |


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If you have been searching for your own unique way to contribute to the Bar, consider signing up for one or two of the Bar's committees. Nearly all committees are filled by appointment of the president-elect, and terms are for one year.
It's your Bar, so get involved!
I suggest the following topic be the subject of a future South Carolina Lawyer article:
I am interested in participating in Law Related Education projects as designated below.
I am interested in authoring a CLE publication or speaking at a CLE seminar.
I would like to help the citizens of South Carolina and promote the legal profession by volunteering the following service(s):
The Directory is a a list of lawyers who have experience in specific areas of the law and is featured on the Bar's website. The deadline to sign up is June 1. Indicate below the specific area of law in which you agree to be contacted. You may only choose a maximum of five areas:
ARLC Administrative and Regulatory Law Committee: Monitor legislation and recommend or review changes to the APA that affects the administrative law practice. Promote better relations between Bar members and hearing officers of government and regulatory agencies and the Administrative Law Court.
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ANIM Animal Law Committee: Provide education and analysis of changes and new directions in animal law. Facilitate cooperation with government agencies and non-governmental humane societies and rescue organizations.
CAL Community Association Law Committee: Engage in legislative and public policy initiatives affecting community associations in South Carolina and develop CLE programs addressing this type of practice.
CHIL Children's Law Committee: Address issues related to children's legal rights and juvenile justice. Coordinate with other children's services groups to improve the way the legal system functions in relation to children. Develop CLE seminars and materials on issues affecting children and those who represent them, both as lawyers and GALs.
CLEP Continuing Legal Education Publications Committee: Oversee the development and publication of CLE publications and software, and recruitment of authors.
CLES Continuing Legal Education Seminars Committee: Oversee continuing legal education efforts through seminars and distance learning products.
CONV Conventions Committee: Enhance CLE programming for the Bar Convention. Consider venue alternatives and generate ideas for social and networking opportunities. Continue to improve the quality of South Carolina Bar Conventions and increase attendance.
ELDER Elder Law Committee: Provide education to members of the Bar and the public on issues affecting the elderly and adults with disabilities. Monitor legislation and propose statutory changes.
ETH Ethics Advisory Committee: Make a difference in helping to protect your fellow attorneys from potential ethical pitfalls and malpractice. The Ethics Committee receives ethics inquiries from members of the Bar in the form of fact patterns and discusses, drafts and produces the ethics opinions.
INHC In-House Counsel Committee: Facilitates involvement and identifies common issues among this sector of the Bar's membership. The committee identifies networking opportunities and practice resources and plans CLE opportunities that focus on issues of concern to in-house practitioners.
INSU Insurance Programs for Lawyers Committee: Study and recommend insurance programs that the South Carolina Bar can make available to its members. Annually review proposed renewal for group medical plan and performance of insurance programs administrator.
INLC International Law Committee: Work with practitioners focusing efforts on the law as it relates to South Carolina's international business community, immigrants, maritime industry and foreign and offshore investors. Support the USC School of Law's Journal of International Law and Business.
LREC Law Related Education Committee: ?Assist with law related education programs, including middle and high school mock trials and other competitions, youth courts, LRE conferences and teacher workshops. Develop LRE materials for teachers and lawyers. Help select award and scholarship recipients.
LHL Lawyers Helping Lawyers Committee: This committee supports the Commission and Director in assisting lawyers and judges who are impaired by alcohol, drugs or depression. The program includes this committee of volunteers who will be trained in recognizing addiction and monitoring those in the program.
PRAC Practice and Procedure Committee: Study and make recommendations regarding the rules and law pertaining to practice and procedure. Continue efforts regarding the improvement of the operation of the judicial system.
PRO Pro Bono Committee: Provide direction and oversight for the Bar's Pro Bono Program including identifying ways to recruit and retain volunteers, support lawyers who take cases and recognize outstanding service.
PROL Professional Liability Committee: Consider issues related to professional liability insurance; assist Board of Governors in its assessment of preferred carriers and agencies.
PROF Professional Responsibility Committee: Become involved in the first step to getting a rule changed. The Professional Responsibility Committee formulates potential changes to the the Rules of Professional Conduct and proposes them to the House of Delegates, which in turn proposes them to the South Carolina Supreme Court.
UPLC Unauthorized Practice of Law Committee: Review allegations of unauthorized law practice. Promote legislation and court actions that enhance the protection of the parties by the prosecution of the unauthorized practice of law.


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Try this delicious recipe!
Servings: Makes 4 servings
Preheat the oven to 425°. Lightly coat a baking sheet with cooking spray and set aside.
Heat a large sauté pan or wok over medium-high heat. Coat the pan with the sesame oil and add the shrimp. Cook for 1 minute on each side. Remove the shrimp from the pan and set aside. Add the cabbage, bok choy, carrots, mushrooms, green onion, ginger and garlic to the pan. Stir continuously for 2 minutes to cook lightly. Season the vegetables with tamari sauce and cilantro and stir well to incorporate. Remove from the heat and place in a bowl to cool. Soak rice papers in bowl of cold water, just until softened, about 30 seconds. Lay rice paper on a cutting board and pat dry. Cut each shrimp in half lengthwise. On the center of each piece of rice paper, lay out 6 pieces of shrimp. Top shrimp with 1/4 cup of vegetable filling, then turn in the sides and roll up like an egg roll. Place spring rolls on the prepared baking sheet. Bake 10 minutes or until spring rolls are light brown and crispy. Cut each spring roll on the diagonal in half. Serve with Sriracha sauce on the side. |


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From: Ronnie Smith, Vice Chancellor, Administration and Finance Subject: Hurricane Katrina Recovery – Update #148 Posted: July 29, 2011
Work on the permanent repairs and mitigation at the Allied Health/Nursing Building continues. The contractor is framing the monumental stairwell enclosure. Additional sheetrock was hung near the rear wall of the auditorium and crews started installing the second layer of gypsum board in the mechanical room behind the auditorium. The contractor is framing the ceiling in the 2nd Floor auditorium and in the corridor behind the auditorium. Workers are installing ceiling grid in the hallway on the MEB side of the auditorium and sprinkler heads in the auditorium and the hallway on the MEB side of the auditorium. The fire pump was set on the 2nd Floor.
The contractor working at the Clinical Education Building continued installing conduit on the 2nd Floor and began installing conduit on the 1st Floor. The freight elevator shaft wall in the basement was poured and crews installed a 6 inch domestic waterline in the basement. Workers began installing the high pressure steam line in the basement. Metal stud bracing is being installed along the corridor wall on the 2nd Floor. All 12 pile caps have been formed, rebar has been installed in 12 of 12 pile caps and concrete has been poured for 9 of the 12 pile caps. Workers started removing the concrete forms and back-filling the pile caps that have been completed.
The CSRB exhaust upgrade contractor made final preparations for the exhaust fan lift and lifted the fans to the roof. Installation of the exhaust fans is underway. The utility pitch pockets for exhaust fan sets 1 -4 were installed and the plenum support for exhaust fan system 10 was set in place.
The project to replace the air handing units in the Dental School Clinic and Administration Buildings is progressing. The contractor continued installing heating hot water lines for units 6A and 3A and made the final connections for unit 3B in the Clinic Building. They continued insulating chilled and heating hot water lines for unit 3A and the existing outside air duct for unit 3A was demolished. The controls contractor installed control wire for units 3A and 3B. Workers finished installing the ductwork for unit 6A and the new ductwork for units 6A and 3A was successfully pressure tested.
The contractor continued installing fresh air and supply air duct for unit 3B in the Clinic Building. Supply duct and heating hot water lines on the 6th and 3rd Floors of the Clinic Building were insulated and supply air duct is being installed in the 6th Floor mechanical room. Workers framed the hard ceiling in the Men's restroom on the 3rd Floor and continued installing drop in ceiling on the 3rd Floor. Sheetrock for the Men's restroom ceilings on the 6th Floor was hung. The contractor also installed a smoke damper between the 2nd and 3rd Floors of the Administration Building.
Work on waterproofing the exteriors of the three main buildings on the Dental Campus is nearing completion. The contractor removed existing caulk and backer rod, prepared the surfaces of the building panels and installed new caulk and backer rod on the north, south, east and west sides of the Power Plant.
Here are highlights of work that has been accomplished during the past two weeks.
We encourage you to follow the details of our progress through the daily updates which are posted on the web site.


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Laptops, Guns Stolen from Corrections Buildings
Alabama Department of Corrections officials say three laptops and four guns have been stolen from state-owned buildings across the street from three correctional facilities. Department spokesman Brian Corbett said Monday that thieves broke into a Department of Corrections farm office and used equipment from there to gain entry to a dog kennel, where a gun safe was raided. Corbett says the buildings that were burglarized are near the Draper, Elmore and Staton correctional facilities and are not monitored by surveillance cameras. Corbett says Department of Corrections employees reported the burglary early Monday morning and officials are taking inventory to determine if anything else is missing. (Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.) |
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Marriage.com is a social Q&A platform for the bridal community. Brides and professionals will be able to share questions, answers, ideas and local referrals. This is crowd-sourcing wedding planning information.
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The Khmer Rouge have been blamed for the deaths of some 1.7 million people [PPU backgrounder] from starvation, disease, overwork and execution between 1975 and 1979. The UN-backed ECCC was established in 2001 to investigate and try those responsible for the Cambodian genocide that resulted in the deaths of approximately one-third of the Cambodian population. In June, the ECCC began the initial hearings [materials; agenda, PDF] in the trial of four former Khmer Rouge leaders [JURIST report] constituting Case 002 [materials]. The four leaders include Nuon Chea, who was Pol Pot's second-in-command and the group's chief ideologist, former head of state Khieu Samphan, ex-foreign minister Ieng Sary, and his wife, Ieng Thirith [case profiles, PDF], who served as minister for social affairs. All four have pleaded not guilty to charges including crimes against humanity, war crimes, genocide, religious persecution, homicide and torture. The ECCC handed down its first and only conviction [JURIST report] last year against Kaing Guek Eav [TrialWatch profile], better known as "Duch", who was in charge of the notorious S-21 prison in Phnom Penh. That case is currently on appeal.
The multiple sets of charges against Zia and her son are part of a political joust between the opposition leader and Hasina. In May 2010, a court dropped corruption charges [JURIST report] against Hasina holding that she had not committed a criminal offense when she used government funds to to appoint US lobbyists to represent the Bangladesh Export Processing Zones Authority [official website] during her 1996-2001 administration. All the cases were brought against Hasina between 2001 and 2008 when she was out of power. Since being sworn into office after her reelection [JURIST report] in December 2008 each charge has either been redacted by the accuser or quashed by the court. Supporters of Hasina claim that the charges filed against her were politically motivated by Zia, the leader of the military-backed regime displaced by Hasina. In April 2009, Bangladeshi judges explicitly dismissed two cases against Hasina on grounds that they were filed to harass her [JURIST report].
The alleged coup plot highlights the continuing power struggle between Turkey's ruling Justice Development Party (AKP) [party website, in Turkish] and the country's secular nationalist establishment, the Turkish Armed Forces (TAF) [official website, in Turkish]. Turkish police detained more than 40 people in connection with the plot in February 2010 and continued to bring charges against alleged perpetrators, but released three high ranking military officials [JURIST reports] just days later. The "Sledgehammer" plot is similar to the Ergenekon [BBC backgrounder; JURIST news archive] conspiracy, in which the secular group is suspected of planning to overthrow [JURIST report] the AKP. The Ergenekon group is also alleged to be involved in bombings, political assassination plots and the death of journalist Hrant Dink [BBC obituary]. The probe into the Ergenekon conspiracy has been criticized as an attempt by the AKP to silence opposition and further its imposition of Islamic principles [DPA report; JURIST report] in violation of Turkey's secular constitution [text]. Trials against the Ergenekon group [JURIST report] opened over two years ago with more than 200 suspects in custody. The suspects include journalists, academics, army officers, policemen and Turkish Workers' Party [party website, in Turkish] leader Dogu Perincek [JURIST report].
Iraq has been closely scrutinized for human rights violations. Amnesty International (AI) [advocacy website] reported in May that Iraqi authorities must end attacks on peaceful protesters [press release; JURIST report]. AI also issued a report in September alleging that the Iraqi government is unlawfully detaining and torturing [press release; JURIST report] thousands of detainees. In June, UN Special Representative to Iraq Ad Melkert urged the Iraqi government [JURIST report] to ratify the UN Convention against Torture and Other Cruel, Inhuman or Degrading Treatment or Punishment [text]. Melkert stated that Iraq had made several advances in recognizing human rights violations, but the government's policy implementation still faces several obstacles. The convention was adopted by the UN in 1984 and has been ratified by 147 countries. Iraq remains one of 45 member-countries that have yet to ratify the treaty. Last April, Human Rights Watch (HRW) [advocacy website] reported on the repeated torture [JURIST report] of Iraqi detainees in a secret prison in Baghdad. HRW reported that detainees held at the secret Muthanna facility, run by Iraqi authorities, were hung upside-down, deprived of air, kicked, whipped, beaten, given electric shocks and sodomized during torture sessions that detainees faced every three to four days.
Kireyev again refused to recuse himself last week, and Tymoshenko announced that she was allowed to call only two of her proposed witnesses [press releases]. In July, the Security Service of Ukraine (SBU) [official website, in Ukrainian] announced that they are launching a criminal investigation [JURIST report] into United Energy Systems of Ukraine (UESU), an energy company at one time headed by Tymoshenko. Last month, Tymoshenko filed a complaint [JURIST report] with the European Court of Human Rights (ECHR) [official website], alleging violations of the European Convention of Human Rights [text, PDF]. The complaint argued that the charges against Tymoshenko are politically engineered by Ukrainian President Viktor Yanukovych [official website, in Ukrainian], Tymoshenko's political rival. ECHR President Jean Paul Costa refused to comment on the complaint [Korrespondent report, in Russian], but said the matter was before the court. The current combined case against her is not the first time she has been prosecuted. Last May, prosecutors reopened a separate criminal investigation [JURIST report] into allegations that Tymoshenko attempted to bribe Supreme Court judges. Tymoshenko's government was dissolved in March 2010 after she narrowly lost the presidential election to Yanukovych. Tymoshenko had alleged that widespread voter fraud allowed Yanukovych to win the election.
The voter ID provision of Act R54 is racially discriminatory and will have a retrogressive impact on the voting rights of minorities in South Carolina. Because there is ample evidence of its retrogressive impact, and given the dearth of evidence for its need, South Carolina has failed to meet its burden under Section 5. For these reasons, we strongly urge the Department to deny the State's request for preclearance or, in the alternative, request more information regarding the law's application and impact on minority voting rights.
There are now 30 US states that require voters to present some form of ID at the polls, including 14 states that require photo ID, but the issue remains controversial. In June, Missouri Governor Jay Nixon [official website] vetoed legislation [JURIST report] that would have required individuals to present government-issued photo ID at the voting booth. In May, the Georgia Supreme Court [official website] upheld a state law [JURIST report] that requires voters to present one of six government-issued photo identifications in order to vote. In contrast, a three-judge panel for the US Court of Appeals for the Ninth Circuit [official website] struck down [JURIST report] a portion of an Arizona law requiring proof of citizenship for voter registration in October.
The Alabama immigration legislation, which was signed into law [JURIST report] by Governor Bentley in June, is one of the most rigid immigration reform laws passed recently. In addition to authorizing detention of individuals on reasonable suspicion they are illegal immigrants, the law provides harsh restrictions on employment for illegal immigrants. Businesses cited multiple times for hiring undocumented workers could lose their business licenses. Furthermore, undocumented immigrants are prohibited from applying for a job, and anyone transporting or harboring undocumented immigrants will be punished by a fine or jail time. Sixteen countries filed briefs [JURIST report] in the Alabama district court against the controversial Alabama immigration law last week, arguing that the recently enacted law unfairly treats citizens [Montgomery Advertiser report] of those countries currently residing in Alabama and sanctions discriminatory treatment based on ethnicity. A group of immigrants filed a lawsuit in an Alabama state court [JURIST report] in late July arguing that the Alabama immigration law conflicts with the Alabama Constitution [text], which expressly encourages immigration. Similar laws have been passed in Indiana, Georgia, South Carolina, Virginia, Oklahoma and Utah [JURIST reports]. Federal courts have enjoined the laws in Arizona, Indiana, Georgia, Oklahoma and Utah [JURIST reports].
An independent commission is currently investigating human rights violations [JURIST report] related to the ongoing pro-democracy protests in Bahrain [BBC backgrounder]. Bahrain's Lower National Safety Court sentenced 21 activists [JURIST report] to eight years to life in prison in June for anti-government protests conducted earlier this year. UN Secretary-General Ban Ki-Moon [official website] condemned [JURIST report] the court for sentencing the human rights advocates, political activists and opposition leaders to harsh punishments. The National Safety Courts, special military tribunals, were instituted in mid-March under al-Khalifa's three-month state of emergency and have been internationally criticized [JURIST reports] by rights group including Human Rights Watch (HRW) [advocacy website]. The court sentenced nine citizens [JURIST report] to 20 years in prison for kidnapping a police officer in May. In April, the court sentenced four protestors to death, a rarity in Bahrain, and upheld the sentences [JURIST reports] for two of the men, who were accused of murdering police officers. All of the charges levied in the National Safety Court have been disputed by Bahraini citizens and international rights organizations.
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Prevent Political Repression in U.S.May 13, 2013Both Democrats and Republicans in Congress seem upset about revelations the Internal Revenue Service focused enforcement actions on conservative political groups during the election campaign last...... oldsteelmakerHoop, if this was Bush on the hotseat, you would be shouting to the rafters. Hypocrite. 0 Agrees | 0 Disagrees | Report Abuse » wvhoopieLike this is the first time this has happened....both sides are both equally guilty of this crap... 1 Agrees | 0 Disagrees | Report Abuse » Chokingsmoker"That is not what the United States stands for - and it must be stopped. Now." Thank you, It is so refreshing to hear from a paper who pretends to have virtues, moral or religious beliefs, and principles, that it does not actually possess. My Moral Compass has now been reset to spin like a neo-conservative Tea Partier. What ever happens, let us pray that the good outstanding business leaders of Wheeling, and West Virginia are NEVER audited by the IRS. AMEN! 1 Agrees | 0 Disagrees | Report Abuse » SpankysLastDanceEvery pinhead out there who put an x next to the "Messiah's" name in 2012 should be investigated and charged with treason or at least be provided psychological treatment. 1 Agrees | 1 Disagrees | Report Abuse » LogHogwhen and if enough information comes out against obomby the commie to damage the Dem. members of congress they will join in to destroy Obama, just like the Repubs. did with Nixon and rightly so. 1 Agrees | 2 Disagrees | Report Abuse » Showing 5 of 5 comments
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Relax in the great outdoors with this folding chair. Features two mesh can holders, a zippered pocket, and its own carrying case. Weight limit 300 lbs.Product Dimensions: 33"W x 36-1/2"H x 21"D; 35"W x 7"H x 5-1/2"D (folded in case).
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Parker sits, Spain defeats France
France did their best to stay with Spain in the first half of Sunday's matchup in the 2011 FIBA Eurobasket, but France just couldn't keep up as Spain throttled them in the second half on their way to a 96-69 blowout.
Can you blame France for being blown out? They were missing two of their best players; San Antonio Spurs' Tony Parker and Chicago Bulls' Joakim Noah.
Spurs draftee Nando De Colo did all he could with 10 points, four rebounds, two assists, and one steal in 27 minutes but Spain had five players finish in double figures as opposed to France's three players.
Juan Carlos Navarro led Spain with 16 points, Dallas Mavericks' Rudy Fernandez had 15 points, Los Angeles Lakers' Pau Gasol had 11 points, and Felipe Reyes and Oklahoma City's Serge Ibaka each had 10 points.
France's Kevin Seraphin led the team with 18 points while Minnesota's Ricky Rubio only played nine minutes in the blowout.


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State Event
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10:30 a.m. registration; 11 a.m. lunch; 12 noon shotgun start; reception to follow Eagle Sponsor: $2,500 (includes foursome, lunch and reception sponsorship and beverage cart sponsorship) Event Sponsor: $2,000 (includes foursome, lunch and reception sponsorship) Foursome: $1,200 Individual golf: $300 Hole sponsor: $250 Meals only: $100 each RSVP to Carrie Zapfe: email@example.com or 317-964-5019 Make checks payable to the Ron Alting for State Senate Committee, c/o SMCC, PO Box 2182, Indianapolis IN 46206
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Pregnant Celebs Bare Their Bumps
Remember when it was a really big deal that Demi Moore showed off her baby bump on the cover of Vanity Fair? Well, we've come a looong way since 1991, folks. Today, celebrity moms-to-be sharing bare belly shots is the new normal. And they don't need a fancy photo shoot to do it — just a camera phone and a Twitter app. Check out these pregnancy selfies shared by the stars...
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Discussion Topics
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Where are the airlines?Apr 25, 20121My sister flies in this Thur on UA, where are the airlines on your maps? Don't you think this information might be useful, this is and AIRPORT not a shopping mall....RAGTue, Apr 24
Fabulous Breakfast!Apr 17, 20120We ordered a quick breakfast early in the morning just a few days after the new terminal and this restraunt opened. We asked the waitress for an extra plate ... Food came VERY quickly plated on two plates. Hot, savory and delicious! Juice and coffee were first rate. We dined in the patio area. A great meal, great service and great experience. We cant wait to dine there again!DairyvilleTue, Apr 17
Apr 8, 20121Escorting two 93 yr olds, my cousin and my uncle, (good walking mobility, but they get confused) from BWI to SMF and then to DEN on Southwest. Need to get my cousin to her daughter in SMF (we arrive 10:40am) and then escorting the my uncle to DEN (departing 11:55am). Where in the airport do I tell the daughter to meet her mom? I and my 93 yr old uncle do not wish to exit security and then have to go through security again, afraid of missing DEN flight. And can you tell me if I can watch my cousin meet up with her daughter from a distance or will I have to take her myself? Or does SMF have a service where personal will escort my cousin to wherever, to meet her daughter? Thanks for your time.debSat, Apr 7


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Why Pledge?
If you're on board with the idea of giving more to the best causes, you might still wonder why you should take the added step of signing our Pledge and joining us at Giving What We Can. We think joining Giving What We Can can make a real difference to the good you can achieve. Here we explain why.
By forming a group, we can accomplish difficult goals that we might have trouble achieving alone. A society of like-minded people can help support us in sticking to the aims we set for ourselves: joining a community with a strong identity is recognised by psychologists as one of the more effective means of inspiring positive behavioral change. 1 For example, group support is key to the success of Weight Watchers as a weight-loss program. 2
Haslam, S. Alexander, Penelope J. Oakes, Craig McGarty, John C.
Turner, and Rina S. Onorato. 1995."Contextual
changes in the prototypicality of extreme and moderate outgroup
members" European Journal of Social Psychology 25: 509-30.
Mcgarty, Craig, S. Alexander Haslam, Karen J. Hutchinson, John C. Turner.
1994. "The
Effects of Salient Group Memberships on Persuasion." Small Group
Research 25: 267-93. (Close
Heshka, Stanley, James W. Anderson, Richard L. Atkinson, Frank L. Greenway, James O. Hill, Stephen D. Phinney, Ronette L. Kolotkin, Karen Miller-Kovach, and F. Xavier Pi-Sunyer. 2003. "Weight Loss With Self-help Compared With a Structured Commercial Program: A Randomized Trial." Journal of the American Medical Association 289 (14): 1792-1798. (Close footnote)
Besides communal spirit, joining Giving What We Can puts you in touch with a range of people eager to find the best means of lifting people out of poverty and equally eager to share their knowledge. Poverty is a complex issue, with important new information emerging every day. It takes a lot to stay on top of it all, and it would be difficult for any one person to do so on their own. Luckily, we don't have to: we can pool our knowledge and share our insights.
Taking our Pledge can also work as a form of 'pre-commitment'. Pre-commitment is a well-regarded strategy for sticking to goals we worry we might not fulfill: we take steps beforehand to ensure that we won't lose sight of our goals later on. We often have difficulty putting our intentions into practice if the costs to us are immediate and the benefits relatively distant. 3 Although we want to be fitter or more successful at work, we may struggle to put in the effort required to achieve those ends. Similar things can occur when it comes to donating to charity. As compassionate and conscientious people, we sincerely want to help others by donating to charity, but often we never quite get round to it. Our impulsiveness means that many donations are made at the last minute 4 or simply forgotten.
Lowenstein, George and Richard H. Thaler. 1989. "Anomalies: Intertemporal Choice" Journal of Economic Perspectives 3 (4): 181-193. (Close footnote)
We can use pre-committment to ensure that we follow through on our good intentions, by making a public pledge to give. There is a large body of evidence to show that pre-committing can help people who want to donate to charity in sticking to their goals. 5 Taking the Pledge to Give and joining a public stand against poverty will thus not only motivate others to do the same, but will secure your own motivation to continue giving.
Breman, Anna. 2006. "Give More Tomorrow: A Field Experiment on Intertemporal Choice in Charitable Giving". Stockholm School of Economics Working Paper. (Close footnote)
We like to make public the names of those who take our Pledge, though we respect anyone's desire to remain anonymous. By making our Pledge public, we can inspire others to give. In particular, we help to establish a norm for giving, and we counteract the Bystander Effect, a well-documented phenomenon in social psychology, explained below.
Our willingness to help others is surprisingly sensitive to the behaviour of those around us. In particular, there are many documented cases, both experimental and real-world, in which individuals have failed to come to the aid of others because they saw that people around them were doing nothing to help. 6 This is the Bystander Effect. Experimental conditions establish that it is the presence of passive others that keeps people from helping: if they are by themselves, people reliably help in similar conditions. 7 Luckily, the opposite effect can also be found. In one field experiment, a radio station would mention to potential donors whenever a previous donor had donated $300: this increased donations by $13 per person. 8 Similarly, student donors are more likely to give to funds designed to help students in financial difficulty when told that a greater percentage of their peers had done so. 9
See Doris, John M. 2002. Lack of Character: Personality and Moral Behavior. Cambridge: Cambridge Univeristy Press, 32-33. (Close footnote)
See, for example, Latané, Bibb and Judith Rodin. 1969. "A lady in distress: Inhibiting effects of friends and strangers on bystander intervention." Journal of Experimental Social Psychology 5 (2): 189-202.(Close footnote)
Shang, Jen and Rachel Croson. Forthcoming. "Field Experiments in Charitable Contribution: The Impact of Social Influence on the Voluntary Provision of Public Goods". The Economic Journal.(Close footnote)
Frey, Bruno S. and Stephan Meier. 2004. "Social Comparisons and Pro-social Behavior: Testing 'Conditional Cooperation' in a Field Experiment". The American Economic Review 94 (5): 1717-1722.(Close footnote)
People are moved, far more than we expect, by the behavioural norms they observe others putting into practice. By making your giving public and joining an international society like Giving What We Can, you can inspire others, and thereby multiply the good you do.
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UMassAmherst: UMass to the net. UMass up by 2 at the half. (link)
UMassAmherst: Full house at the Mullins Center for last men's basketball reg season game. #goUMass (link)
UMassAmherst: Chaz Williams honored at Senior Day -- UMass basketball (link)
UMassAmherst: Raphael Putney honored on Senior Day -- UMass basketball (link)
UMassAmherst: Amherst Middle School sings national anthem at today's men's basketball game #GoUMass (link)
UMassAmherst: Sunny day in Amherst as sell out crowd enters Mullins Ctr for last reg season men's basketball game (link)
UMassAmherst: Hoop Band wearing t shirts showing support for Krystle Campbell scholarship fund (link) (link)
UMassAmherst: RT @UMassAthletics: .@CoachKellogg meeting with CBS Sports Network crew prior to today's game. #GoUMass (link)
greenriverfest: kick-off countdown day 23. Hey, is that Troy "Trombone Shorty" Andrews & Orleans Avenue leading the kid's... (link)
UMassAmherst: RT @UMassAthletics: The @MullinsCenter is ready for #UMass vs #17 Saint Louis...Are you? #RallyTowelCity #GoUMass (link)


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Oprah Winfrey's cable channel struck a distribution deal with Comcast Corp., CMCSA -0.52% lifting the number of homes in which the network can be seen. Christopher Stewart has details on Lunch Break.
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To Foster Communication, Bay Area Boss Cut Off Email
Feb 10, 2013 (Weekend Edition Sunday) — Shayne Hughes, CEO of Learning as Leadership, thought his staff had become too dependent on email to communicate. So he launched an experiment: no internal email for one whole week.
Missing some content? Check the source: NPR
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Sellers at Tesco are third party sellers we have invited to sell on Tesco direct. These are companies we've selected to provide you with a wider range of products to choose from in one place. They are a mixture of well-known high street retailers and specialist retailers who operate online. Plus, you earn Clubcard points on all seller orders.
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The Tommee Tippee electric bottle and food warmer is great help for combining breast and bottle feeding.
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News 2012
News 2012: (US) Unquiet Thoughts: "Saturday quotes 2.25 Dowland's training part 4"
(From a recent newsletter)
"In previous posts, we outlined information highlighting typical modes of musical education in Tudor England. The pathway to a musical education for a member of the artisan class seems to have begun with grammar school, …"
… The earliest records of Dowland as a musician reveal that in 1580 he was servant to Sir Henry Cobham (1538 – c.1605), Ambassador to the King of France. …"
Visit the Unquiet Thoughts blog website to read the full and informative post. You may even read the previous connected posts on their site.


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Hanging from your ceiling, the Branches Pendant will evoke an elegant, country feel. Inspired by nature, this light is perfect for rustic country or Asian-influenced designs alike. Brighten your home and order the Branches Pendant today.
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Tagged: carbon emissions
The UN Climate Change Conference in South Africa, COP17, has come to a close but the battle against climate change continues. In this film we look at the outcomes from Durban and the broader issues around getting a global climate deal to keep warming below two degrees.
As the climate talks in Durban enter the final day the emerging deal remains uncertain. But the catastrophic climate impacts the world faces if tough and ambitious decisions are not taken within the next 24 hours are crystal clear.
On the middle Saturday of the UN Climate Change Conference, COP17, Oxfam along with thousands of people took part in a peaceful march through Durban to demand action on climate change.
World leaders could make significant progress toward a climate fund for developing countries when the United Nations Climate Change Conference (UNCCC) resumes talks in Tianjin , China.


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- May 13, 2013
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This traditional dish from Uttar Pradesh can be easily made at home and tastes the best with dahi and imli chutneyIngredients:1/2 kg - Besan (Gram flour)1 tsp - Mustard Oil1 tsp – Salt1 tsp - Red chilli powder1 cup – Water1 tsp - Methi leaves (chopped fine)1/4 kg - Maida (Flour).Method:Mix besan, salt, red chilli powder and oil wellKnead the mixture into doughAdd methi leaves and knead again to soft dough.Heat oil in a deep-frying pan.Rub some oil on your palm and roll out the dough into a long strip one inch thick.Cut the roll into inch size pieces.Flatten each piece out into a round shape and roll it into small chapatis.Lightly dust both sides of the small chapatis with maida.Fry very lightly to a golden yellow color, turning the flame from medium to low as required.Drain oil using the sieve type ladle.
Made of lentils, the vadas are deep fried and is best served with dahiIngredients1 kg Urad Dal2 pcs (small) Hing3 tsp Salt4 tsp Rai (finely ground)2 tsp Red Chilies (pounded)6 jugs WaterOil, for deep fryingWhole Red Chilies, for garnishMethodSoak urad dal overnight and grind to the consistency of a cake batter.Whisk the paste till it is fluffy.Heat oil well in a deep frying pan.Slide the small paste-parts into the heated oil and deep fry to a golden brown color.Take care not to make the vadas too thick.Take them out with a sieve type ladle and drain the oil completely.Keep a tawa on the fire and heat crystals of hing on it.As soon as it gives off the fragrance, turn an earthen pot on it.Take it off the fire and fill it with warm water.Mix rai, salt, red chilli powder and whole red chillies into the water.Put the fried vadas into the matka.Clean the top of the matka and cover it with a clean muslin cloth and securely tied.Leave the matka in the sun during the day for eight days before it is ready to be served.
The quintessential onions fritters can be eaten with thandai or bhang. IngredientsChickpea Flour (Besan)1 cup Oil2 tbsp Ground Cumin1 tsp Salt1 1/2 tsp Chopped Green Chillies (Jalapeno) 1-2 each1/2 cup Water1 1/2 cup Sliced OnionMethodMix first set of ingredients well. Beat in a blender for 4-5 minutes to incorporate air (this will make the batter fluffier).Let batter rest 1/2 hour in a warm place.Dip onions in batter to coat.Deep fry in oil that is heated to 375°.Drain on paper towels and serve immediately.Serve with cilantro or mint chutney.
Holi lunches are incomplete without Kesar chawal. The yellow rice is a must for every Holi lunch.Ingredients1 cup long grain Indian Basmati Rice2 cup warm water and extra water, for washing and soaking riceSalt to taste1/4 tsp Saffron Strands1 Bay Leaf2 - 2 inch Cinnamon Sticks4 Green Cardamoms15-20 pieces of Paneer (Cottage Cheese) cubes (about 1cm x 1 cm each)1/3 cup Raisins10 Cashew NutsA little Hot Milk2 tbsp Ghee (clarified butter), for fryingMethodWash rice thoroughly and soak in water for half an hour. Drain thoroughly.Soak saffron in a little hot milk for about 15 minutes, till milk is a deep orange-yellow colour. You may vary the quantity of saffron, depending upon it`s quality.Heat oil in a wok. Fry the cashewnuts till golden. Drain and set aside. Next, fry the paneer cubes, till light golden, drain and set aside.In a pan, heat ghee or clarified butter. Add the bay leaf, cardamom and cinnamon.Add the rice. Add salt. Stir till ghee coats every grain of rice and rice looks glossy.Add warm water. Bring to a boil. Add the raisins. Stir once.Reduce heat to minimum and cover the pan with a lid. When holes appear on the surface and water has almost evaporated, lightly fork in the paneer cubes. Sprinkle the saffron liquid on top.When water has completely evaporated, fork the rice out onto a serving serving dish. This will separate each grain out. This rice will have a beautiful mix of white and yellow and half coloured grains.Garnish with fried cashewnuts. Serve hot with any creamy curry.
This delicious drink, a must during Holi and Shivratri, adds charm to the festivals.Ingredients:11/2 liter Milk 1/2 cup Sugar(or as per taste) 1/2 tbsp Aniseed 1 tbsp Almonds A few Saffron Strands 1 tsp Cardamom powder 1 tbsp Dried watermelon seeds 1/2 tbsp Poppy seeds 1/4 Cup fresh rose petalsMethodBoil milk and allow it to cool. Meanwhile soak aniseed, almonds, watermelon seeds, poppy seeds and rose petals in water. Grind soaked ingredients to make a smooth paste. Pour some water into this paste and strain through muslin strainer. Extract the liquid into a vessel. Add the sugar, peppercorns, powdered cardamom, saffron and mix well. Now blend the above-made mix with milk. It is preferable if it is full cream. Chill before serving. You can also add ice cubes.
Holi is unimaginable without Gujia. Now you can make the perfect Gujias by following this simple recipe. Ingredients550 gms maida (flour) 1.25 kg khoya 5 tbsps raisins200 gms almonds (cut into thin strips) 6 tbsps cooking oil. (keep some more aside for deep frying) 200 ml water 500 gms sugarMethodMix the six tablespoons of oil with the maida. Now add some water as required and knead into soft dough. Set aside and cover with a damp cloth. Fry khoya in a deep-frying pan to a light brown colour. Add sugar, almonds and kismis into the khoya and mix well. Remove from the fire and let it cool.Roll out the kneaded dough into a small and thick chapatti. Fill half the chapati with the khoya mixture and seal the round, twisting the edges inwards. Deep-fry these gujias to a deep golden brown colour on slow flame. Take them out with a sieve type ladle and drain the oil completely.
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The best products for 'green' spring cleaning
It's the season for spring cleaning -- but what products will you use? Choosing eco-friendly products doesn't have to be a difficult task.
Wednesday - 05/08/2013, 04:18pm EDT
Tags: Joan Michelson, green, environmentally friendly, spring cleaning, women


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By Mr. Barrows of Mansfield, a petition (accompanied by bill, House, No. 1672) of F. Jay Barrows and others for legislation to provide for an income tax credit for expenditures for the design, construction, repair or replacement of failed cesspool or septic systems. Revenue.
Sponsors: | |
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Petitioners: F. Jay Barrows, Paul K. Frost, Randy Hunt, Bradley H. Jones, Jr., Kevin J. Kuros, Shaunna O'Connell, Elizabeth A. Poirier, Daniel K. Webster, Colleen M. Garry


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Poetry Magazine
Tears, Oily Tears . . .
Source: Poetry (November 2009).
Poems by James Schuyler
Poem Categorization
SUBJECT Living, Sorrow & Grieving, Arts & Sciences, Reading & Books
SCHOOL / PERIOD New York School
Poetic Terms Free Verse
If you disagree with this poem's categorization, make a suggestion.
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Elections in Syria
This article needs additional citations for verification. (December 2013) |
This article is outdated. (June 2012) |
This article is part of a series on the politics and government of Syria |
Foreign policy
Alternative government
Elections in Syria gives information on election and election results in Syria.
As of 2014, Syria is divided between two governments, both of which make contested claims to be the only true democratic government of Syria. A bitter civil war between the two has raged since 2011 following a period of unarmed demonstrations and unrest in 2011, which was part of the international wave of protest known as the Arab Spring.
The Baathist government, headed by Bashar Assad, son of previous leader Hafez Assad, is based in Damascus, the traditional capital. The National Coalition for Syrian Revolutionary and Opposition Forces is conducting its first regional elections in early March 2013 for Aleppo, Syria's largest city and main commercial hub. Due to fighting, the elections are being held by 200+ representatives in Ghazi, Turkey.
Both of Syria's major cities are divided, as both sides have forces in each other's respective strongholds in the north and south. The western coastal areas, heavily populated by members of the president's sect, the Alawites, are firmly under Damascus' control. The eastern areas of Syria, much of which are populated by Kurds, are almost entirely outside of Damascus' control. Druze and Palestinian areas in the south suffer from divided loyalties, and the area of central Syria between the two capitals is a region of mixed pockets of control and hotly contested highways and other essential supply lines. There are fighters and equipment from other nations on both sides of the conflict, and the UN security Council has been divided and largely powerless to affect conditions in Syria.
Damascus government[edit]
Syria elects on national level a head of state - the president - and a legislature. The People's Council (Majlis al-Sha'ab) has 250 members elected for a four-year term in 15 multi-seat constituencies. According to previous Syrian constitution of 1973 Syria was a form of single-party state in which only one political party, the Arab Socialist Ba'ath Party was legally allowed to hold effective power. Although minor parties were allowed, they were legally required to accept the leadership of the dominant party. The presidential candidate was appointed by the parliament, on suggestion of the Baath Party, and needed to be confirmed for a seven-year term in a national single-candidate referendum. The most recent presidential referendum took place in 2007. The new Syrian constitution of 2012, approved in popular referendum, introduced multi-party system without guaranteed leadership of any political party.[1] In a new article 88, it introduced presidential elections and limited the term of office for the president to seven years with a maximum of one re-election.[2]
During the French Mandate and after the independence the parliamentary elections in Syria have been held under a system similar to the Lebanese one, with fixed representation for every religious community, including Druzes, Alawis and Christians. In 1949 the system was modified, giving women the right to vote.[3][4][5][6]
Election law[edit]
On August 2011 President Assad signed Decree No. 101 on amending the General Elections Law. The Law stipulates that elections are to be held with public, secret, direct and equal voting where each Syrian voter, who completed eighteen years old, has one vote. The Law does not allow army members and policemen in service to participate in elections. It also provides for forming a higher judicial committee for elections with its headquarters in Damascus to monitor the elections and ensure its integrity, in addition to forming judicial sub-committees in every Syrian province affiliated to the higher committee.[7]
Aleppo government[edit]
The rebel-held areas of Syria have gone through three phases. First, there was a political organization of exiles, the Syrian National Council, which had little connection to local areas and militias.
Local leaders and militia heads were incorporated with the SNC to form the National Coalition for Syrian Revolutionary and Opposition Forces in November 2012, with a leader, Moaz al-Khatib, elected by its assembly met in Doha, Qatar.
In March, 2013, representatives of local areas in Aleppo city and province met in Ghazi, Turkey, to elect a city council and provincial council.
See also[edit]
- ^ SANA Syrian News Agency - Constitution of the Syrian Arab Republic Approved in Popular Referendum on February 27, 2012, Article 8
- ^ SANA Syrian News Agency - Constitution of the Syrian Arab Republic Approved in Popular Referendum on February 27, 2012, Article 88
- ^ "The Arab-American handbook: a guide to the Arab, Arab-American & Muslim worlds", Nawar Shora. Cune Press, 2008. ISBN 1-885942-47-8, ISBN 978-1-885942-47-0. p. 261
- ^ Albert H. Hourani, Minorities in the Arab World, London, Oxford University Press, 1947 ISBN 0-404-16402-1
- ^ Claude Palazzoli, La Syrie - Le rêve et la rupture, Paris, Le Sycomore, 1977 ISBN 2-86262-002-5
- ^ Nikolaos van Dam, The Struggle For Power in Syria: Politics and Society Under Asad and the Ba'th Party, London, Croom Helm, 1979 ISBN 1-86064-024-9
- ^ President al-Assad Issues Legislative Decree on General Elections Law, SANA news agency
External links[edit]


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Your search for FOOTBALL in Hurricane Katrina returned 66 articles
In Louisiana's River Towns, a Flow of Talent
The presence of the Ravens' Ed Reed and Jacoby Jones provide a 16th consecutive Super Bowl with players from Louisiana, where more N.F.L. players hail from than any other state.
February 3, 2013, SundayWhere Waters Receded, Scars Remain
Seven years after Hurricane Katrina, the New Orleans neighborhood where Marshall Faulk grew up lags behind the city's recovery.
January 31, 2013, ThursdayIn Step With New Orleans's Comeback
For the Saints owner Tom Benson, who ultimately did not move his team after Hurricane Katrina, hosting the Super Bowl represents a crowning moment in New Orleans's renaissance.
January 29, 2013, TuesdayFor New Orleans, Bowl Is a Happy Return
Even people who don't care about football should be cheered that the Super Bowl is back at the Superdome.
January 29, 2013, TuesdayThe Capital of Sports
From Dec. 26 through Monday, the Superdome and the neighboring New Orleans Arena have hosted, or will host, nine sporting events.
January 7, 2012, SaturdayChamps? The Saints, Dat's Who
The Saints, long associated with losing and disappointing their fans, defeated Peyton Manning and the Colts in Super Bowl XLIV and gave New Orleans a reason to cheer.
February 08, 2010, MondayLong-Suffering Saints Fans Could Use Some Good Times
If there is any justice in the universe, New Orleans will win the Super Bowl against Indianapolis next Sunday.
January 31, 2010, SundayBursting Pride in Super Bowl Team Replenishes a City
In a city that has been associated over the last four and a half years with divisiveness and suffering, the delirium over the Saints is pretty much unanimous.
January 29, 2010, FridayBrees Sees the Stars Aligning for New Orleans
Drew Brees, the Saints' quarterback since 2006, hopes to lift the Saints and the city that adopted him to unprecedented success.
October 04, 2009, SundayAt Tulane, Sports Revival After Katrina's Wind and Water
The energy on campus is a dramatic change from when Hurricane Katrina knocked the Tulane athletic department to the ground, threatening its very survival.
October 08, 2008, WednesdayComeback Kids
How a community battered by Katrina fielded a championship football team.
September 07, 2008, SundayNew Orleans Arena League Team Casting Quite a Spell
After a season lost to Hurricane Katrina, the New Orleans VooDoo, aspiring champions of the Arena Football League, have enjoyed the embrace of a damaged city.
April 29, 2008, TuesdaySetting May Be More Significant Than the Actual Game
The theme of championship week has been curiosity; concern over the healing process of New Orleans, a great city that was turned inside out by Hurricane Katrina.
January 08, 2008, TuesdaySouth Plaquemines Wins the Title
Quarterback Ridge Turner passed for two touchdowns and ran for three more as South Plaquemines High School defeated West St. John, 48-8, on Saturday for the Louisiana Class 1A state title.
December 09, 2007, SundayA Razor-Sharp Focus Trumps Uncertainty
The South Plaquemines High football team, which will be playing for the Louisiana state title, has provided a symbol of resilience for a vulnerable region.
December 05, 2007, WednesdayFires a Reminder: What Happened to Aaron Brooks?
Two years after quarterback Aaron Brooks criticized the N.F.L. and the Saints' team owner for failing to help the team cope with Hurricane Katrina, he's out of the league. Was it something he said?
October 27, 2007, SaturdayA Rebirth, and Then a Relapse for the Saints
A year ago, the New Orleans Saints started 3-0 in what became an inspiring season that ended one game short of the Super Bowl. This year, the Saints exist in Bizarro World.
October 07, 2007, SundayWorries Aren't Weatherproof for High School Football Team
For the South Plaquemines Hurricanes, a fragile post-Katrina normalcy was set on edge on Saturday when their season was threatened by another tropical storm.
September 25, 2007, TuesdaySetting the Stage for 2 Bowls in a Week
New Orleans will play host to the Sugar Bowl on Jan. 1 and the national title game on Jan. 7 in the second year of college football's double-hosting format.
April 29, 2007, SundayThe Football Is Fine, but the Saints' Finances Aren't So Bright
The Saints' 2006 season has been, by some measures, a rousing success. Still, Forbes magazine's estimate of the team's worth ($738 million) ranked the Saints 27th out of 32 N.F.L. teams.
January 17, 2007, WednesdaySaints Give City Reason to Cheer
The struggling, half-filled city of New Orleans, hit a little more than 16 months ago by Hurricane Katrina and now in the midst of a spree of murders, has found an escape route.
January 14, 2007, SundayAints to Saints, Child to Man, a Family Affair
Since Hurricane Katrina, the resurgent New Orleans Saints may be America's team, but they are not completely Louisiana's team. Mine remains a family divided.
January 10, 2007, WednesdayThank You From New Orleans
To the Sports Editor: The series of Jeré Longman articles on the South Plaquemines High School football team, the Hurricanes, in southern Louisiana looked at the broad repercussions of Hurricane Katrina on the daily lives of families on the Gulf Coast.
December 17, 2006, SundayFormer Coach Watches From a Seat, Not the Sideline
A former coach watched two Louisiana high school football players whom he groomed win a state championship trophy that will go into someone else's trophy case.
December 12, 2006, TuesdaySeason of Renewal Ends in Defeat and Doubt
South Plaquemines High's storybook Louisiana state football playoff run came to an abrupt end Friday as the Hurricanes lost to Clinton, 48-16.
November 21, 2006, TuesdayLife Is Complicated at Louisiana School
When they are not coming from behind to win high school playoff games, South Plaquemines football players are facing issues like fatherhood and job prospects in the wake of Katrina.
November 15, 2006, WednesdayFinding Their Way in the Dark
Through blackouts and short fuses, the South Plaquemines Hurricanes are led by their determined football coach.
November 10, 2006, FridayMother Helps Her Son Find a Safe Harbor in Football
Anthony Kap is an undersized but eager linebacker at South Plaquemines High, which was opened after Hurricane Katrina to educate students from Port Sulphur, La., and other devastated communities.
November 03, 2006, FridayAmerican Tragedies, to Sell Trucks
Patriotic images are a mainstay of advertising, but new G.M. commercials depicting national tragedies cross a line.
October 30, 2006, MondayNo School Is an Island
To the Sports Editor: As a football mom, I was pleased that you praised students at South Plaquemines High School in Louisiana for their mettle in the face of the devastation wrought by Hurricane Katrina (''Homecoming Is a Victory, by Any Definition,'' Oct. 25). But the way you pitted their...
October 29, 2006, SundaySEARCH 66 ARTICLES ABOUT HURRICANE KATRINA:
Saints Return to Superdome
It was an all-day party in New Orleans, as Saints football returned to the Superdome. Producer: Kassie Bracken
- Op-Ed | Timothy Egan: Paul Ryan's Irish Amnesia
- Billionaires With Big Ideas Are Privatizing American Science
- The Science of Older and Wiser
- Opinion: Where Are the People of Color in Children's Books?
- Income Gap, Meet the Longevity Gap
- Op-Ed Columnist: Go West, Young People! And East!
- For Starters, the Upper East Side
- Opinion: Learning From Legos
- Synagogue, Rebooted
- Op-Ed Columnist: The Three Faces of President Obama
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BP Comment Quick Links
August 23, 2013 Raising AcesThe RP-Funk All-StarsStarting pitchers tend to receive most of the attention devoted to pitchers, both in Raising Aces and within the general community of baseball evaluators. Yet some of the most intriguing pitchers in the major leagues hail from the bullpen. Starters tend to adhere to a prototypical build designed for stamina, but relief pitchers come in all shapes and sizes, often earning their roles as a direct result of the perception that they cannot withstand the rigors of a 200-inning season or a seven-inning appearance. There are a multitude of reasons why a pitcher might be assigned to relief work, including body type, pitch selection, and/or mechanical trends. When it comes to mechanics, a pitcher with a funky delivery can be sent to the pen just as quickly as one whose motion is perceived as dangerous. These attributes can be intertwined, as the same elements that make a delivery look goofy can also present the risk of injury. Other times, a pitcher's mechanical approach is geared toward deception, creating strategic angles that are designed to exploit platoon splits or to exaggerate downhill plane. At the Sabermetrics, Scouting, and Science of Baseball conference that took place last weekend in Boston, former pitcher Brian Bannister spoke glowingly of the advantages inherent in an eccentric motion. The potential downsides of an unusual delivery are minimized in the bullpen, with lower workloads and short stints acting to minimize the risk of overexposure. So with a nod to Bannister and George Clinton, I present the RP-Funk All-Stars of the 2013 season. "Hip Hop"
Walden's delivery is pretty normal during the lift phase of his delivery, but just when it looks like he's about to hit foot strike, the right-hander's back foot leaves the ground. The bunny hop acts to extend Walden's stride, but the disruption to his balance is a precursor to inconsistency at release point. He essentially leaps onto the front foot, with all of his weight coming down on the unstable foundation at foot strike, while the back ankle looks like it might snap as it touches down. Walden also has some flail to his delivery, with heavy flexion and a soft glove side into release point, but the hip-hop stride is trademark funk. One would expect that he would never hit his targets, and a lack of command did define the first several years of Walden's career, but he has been able to harness the leap of faith in his first season with Atlanta. His walk rate is three points lower than his previously established mark of 10.5 percent, yet he has maintained a strikeout rate a tick above his career average.
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Pinion sealed gearbox offers an alternative to those darn derailleurs
By Ben Coxworth
March 13, 2013
Rear derailleurs are problematic, particularly on mountain bikes. They get bent, they get gunked up, and they're exposed to the elements. While sealed hub transmissions lack these problems, not all of them have axles that are strong enough for multi-terrain use, they add revolving weight, and that weight is added in the back of the bike – not low and in the middle, where you want it. German company Pinion has developed what it claims is something better ... a sealed gearbox located adjacent to the bottom bracket.
Known as the Pinion P1.18, the device has been in development for the past seven years. It was launched commercially just last year, and recently gained attention when it appeared on an award-winning bike at the North American Handmade Bicycle Show.
So, how does it work? Well, to quote the Pinion brochure:
"The Pinion P1.18 bicycle transmission is constructed as a spur gear with two parallel partial shaft transmissions, one with three gears, and the other with six gears. The multiplication of three by six ratios gives 18 real ratios spaced in even, ergonomically ideal, steps of 11.5 percent. The P1.18 thus achieves a total gear ratio of 636 percent."
The gears are lubricated with a 60-milliliter oil bath, that the company states should be changed once every year or 10,000 kilometers (6,214 miles) – no other maintenance is required. The gears are said to be good for at least 60,000 km (37,282 miles).
Because indexing of the shifts takes place within the box, users don't have to worry about replacing stretched shifter cables. Gear changes are activated via a SRAM-like grip shifter, are reportedly "lightning fast," and can span several gears in one shift. Additionally, they can be performed even when the cranks aren't turning.
It sounds good, but of course nothing is perfect. For one thing, the P1.18 can't simply be installed on an existing bike – the frame has to be designed around it. Additionally, the gearbox itself weighs in at around 2.7 kilograms (six pounds) – for comparison, the combined weight of a Shimano XT front and rear derailleur sits at about 384 grams (0.9 lbs).
It should be kept in mind, however, that the P1.18 makes a cassette unnecessary, plus it incorporates components such as a bottom bracket shell and axle. It also allows for the use of a belt drive instead of a chain, which plenty of folks would no doubt appreciate.
Because it can only be built into dedicated frames, the Pinion P1.18 isn't currently available to the general public. A list of manufacturers using it on their bikes can be accessed via the company link below.
Its hardly the first, SR Suntour do the 9 speed gearbox in almost exactly the same fashion....
Jabboson13th March, 2013 @ 06:08 pm PDT
I love the idea, but I guess it will come down to how heavy a bike is using it. As pointed out above, the frame and pedal infrastructure would be quite different (no cassette etc...). It might be possible to replace some of the frame too by using the gear case as part of the structure. Maybe this wouldn't be used by pro racers, but for commuters and weekend warriors the ease of maintenance and convenience might win through.
Scion13th March, 2013 @ 06:22 pm PDT
Would be nice to know how this compares to something like the NuVinci CVT transmission.
Max Kennedy13th March, 2013 @ 07:49 pm PDT
"not all of them have axles that are strong enough for multi-terrain use,"
The Nuvinci has a solid axle. Plenty strong.
"they add revolving weight,"
Near the center of the hub, where revolving mass matters least.
"and that weight is added in the back of the bike – not low and in the middle, where you want it."
I don't see how the center of a hub is any higher than the bottom bracket, especially since the Pinion extends above the BB.
"The multiplication of three by six ratios gives 18 real ratios spaced in even, ergonomically ideal, steps of 11.5 percent."
The Nuvinci is ergonomically ideal because it has infinite ratios. Even owners who don't like the weight will attest to that. You can always find the perfect gear, not just something close. Also, consistent gaps aren't optimal. The thinking has always been smaller gaps in higher gears and larger gaps in the lower gear range.
Gadgeteer13th March, 2013 @ 07:50 pm PDT
Heavy or not, still sounds good to me. Fiddling with gear changes is a pet hate ... anything that simplifies the process would be welcome. Didn't somebody invent an 'automatic' bike gearbox a while ago though? Just pedal and it changes up (or down) as the needs of the bike change.
The Skud13th March, 2013 @ 11:36 pm PDT
I have a Sram iMotion 9 hub and rarely go above gear 6. I think a 9 (3x3) or 12 (3x4) gearbox would have been more relevant, lighter and cheaper. Shimano have an 11 speed Alfine, and Rohloff had the previous record of 14 speed.
clau_sav14th March, 2013 @ 08:52 am PDT
Rohloff Speedhub
Superior in every way.
William Volk14th March, 2013 @ 09:17 am PDT
omg its not weightless! wharever.
some others are fragile! yes...others.
lets see one in "plastics with silicon bronze bearing surfaces for liwest lowest friction and weight. perhaps a 3d printer expert can program one up.
me. i want one that has edrive incorporated and can hanfle regen. lacking that..one that is fast detatch.
waltinseattle14th March, 2013 @ 09:21 am PDT
all we need is a 3d printer and the file..
(6 lbs!)
no mention of cost
looks like about $500
wle14th March, 2013 @ 10:09 am PDT
Fine for a commuter bike in Holland where there are no hills and the lack of cables might be viewed as advantageous. This is a good example of design engineers starting with a project before they fully understand the problem and what users actually like and do not like with current solutions. The Italians have been producing pre-stretched cables for decades that greatly reduce and needed adjustments and the shift lever mounts often include tension adjustment mechanisms.
This design still makes use of the chain which is the one item that the average commuter would like to have go away.
Calson14th March, 2013 @ 10:21 am PDT
Walt, type at a slower speed and put at least some effort into observing the preferred rules for spelling and grammar.
Beyond that criticism I would like to see someone do a competent engineering study comparing the various CVTs, belt drives, transmissions, along with costs. BTW, a few more ponds in a transmission is really irrelevant if you just add a bigger battery for the front wheel motor. I have used bikes for around town transportation for over forty years. I do not care if the whole bike weighed three ponds wet, having some extra push from a pedelec is worth it.
StWils14th March, 2013 @ 10:37 am PDT
Oh, to return to the days of yore when all we had was Sturmey Archer's 3 and 4-speed hubs. Simple, safe, cheap - as opposed to the 'unsafe and any speed' derailier contraptions they force on us today.
Dave Brough14th March, 2013 @ 11:08 am PDT
Literally a go back to the past!! which means maybe the bicycles are "improving" their gears
Tiago Roque14th March, 2013 @ 04:20 pm PDT
I suspect that this transmission has more friction than a good derailleur transmission.
Slowburn14th March, 2013 @ 05:46 pm PDT
Love it and would opt for the belt drive for sure. If I can stand on it and apply max pedal power without breaking it (200lb of mostly muscle between my ears) I would trade the additional net weight (maybe 2 to3 lb) as compared to derailleur, cassette, etc. Nothing like the sweet action of German gears and bearings.
Mirmillion14th March, 2013 @ 06:23 pm PDT
As with all issues regarding energy use or conversion it is a matter of efficiency, cost and versatility. This solution have been on my wish list for many years but now I think that an electric generator - supercap - battery - hub motor(s) is the optimal driveline when using modern high efficiency power electronics.
Kenneth Palmestål15th March, 2013 @ 03:21 am PDT
We look forward to a "Shaft-Drive" version! ...Why not?
Alastair Carnegie15th March, 2013 @ 09:37 am PDT
hm, seems quite strange since there is already truvativ hammerschmidt or schlumpf dual speed chain wheel...I cant see strong benefit, as there is still rear chain guide :-(
I bought oldschool Sturmey-archer X-RF8 which is fine, see
15th March, 2013 @ 10:06 am PDT
One of the weaknesses of a chain/derailleur is gear range duplication. A dedicated cyclist will build their own rear gear cluster and choose their front chain wheels to customize their shift points and limit ratio overlap.
The second major weakness of derailleurs is seen when on tries to shift in high torque circumstances such as honking up a hill. Even when the best riders and mechanics tune a riders bicycle it's common to for the chain to slip 5 to 10 gear teeth or throw the chain completely. If the chain gets bound up behind the rear gear cluster and spokes or the front of the gear stack and the frame, the rider is going down and there's not a hell of a lot that the rider can do about it. I broke an ankle from the sudden impact of a chain jamming. That was during my freshman year in high school when I rode an average of 70 miles a day.
The gearbox concept eliminates those problems, but I have to wonder how precisely, quickly, and smoothly they'll complete the high torque shifts. Since I can no longer ride a conventional bicycle. The gear box concept would be ideal for hand powered bikes.
Noel Frothingham15th March, 2013 @ 07:18 pm PDT
re; Alastair Carnegie
Shaft drive bicycles have two high friction gear sets. I would rather drag a meter wide parachute.
Slowburn16th March, 2013 @ 03:49 am PDT
How does it compare to a Schlumph drive?
James Donohue8th April, 2013 @ 08:23 am PDT
Why do sealed drive bikes not exist?
Not like pinion just a derailuar in a box
Sealeddrive24th December, 2013 @ 02:42 am PST
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