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Great Lakes Miami Weiss - Great Lakes Brewery
Displayed for educational use only; do not reuse. |
Ratings: 68 | Reviews: 43 | Show All Ratings:
3.48/5 rDev -11.7%
look: 4 | smell: 3.5 | taste: 3.5 | feel: 3 | overall: 3.5
Appearance - Very clear, very pale yellow with a nice, long-lasting head. Good lacing.
Smell - somewhat faint smell of wheat and citrus-floral hops with a touch of pineapple juice. Nothing "off," but nothing that stands out.
Mouthfeel - a tad overcarbonated for an almost abrasive texture.
Taste - very faint wheat malt flavour and bitter hops with a faint hint of pineapple.
Serving type: bottle
10-24-2011 23:22:21 | More by
Ontario (Canada)
3.63/5 rDev -7.9%
look: 4 | smell: 3.5 | taste: 3.5 | feel: 3.5 | overall: 4
This bright, clear beer could certainly take its talents to South Beach; anything this golden-yellow, with rhythmic bubbles and sunny disposition, looks ideal for a warm-weather climate. Condensation on the glass even emulates the Floridian humidity. It has a respectable level of head that leaves a token level of lace.
The brewery admits that this isn't technically a Weiss - good thing too, because if they hadn't I'd have nailed them for it. It has none of the fruity or clove-y yeast characteristics of that German style... but fortunately it does have a wee bit of the bitter, lemony features of American wheat beers. Still, it leaves much to be desired.
I'd like to be saying "Come on, shake your body baby, do the conga, I know you cant control yourself any longer", but truth be told, Miami Weiss (this bottled batch of it, anyhow) is a fairly pedestrian American-style wheat beer. It tastes of malted wheat, with a bit of biscuity barley malt, and has an underlying canned pineapple hoppiness.
Unlike its Project-X predecessor variations, this lacks in hop depth. Its bitterness is grassy and only minimally candied or fruity. Technically, though, it is a flawlessly brewed beer, albeit a little too simple in the flavour compartment. The finish is dry and plain (like crackers), with a rough bitterness and nothing to make you say "ay papi!"
Great Lakes Miami Weiss is like the Miami Dolphins - a once great franchise that has been reduced to mediocrity, unable to compete within its division. Tremendous packaging aside, this current beer doesn't come close to its inspired recipe and can't walk the strip with the likes of other, more celebrity American-style wheat ales. Final verdict: a B-Lister.
Serving type: bottle
10-01-2011 04:46:09 | More by biegaman
Ontario (Canada)
3.9/5 rDev -1%
look: 4 | smell: 3.5 | taste: 4 | feel: 4 | overall: 4
Purchased this without too much excitement. I havnt found one of their beers I "Loved" Just yet.
This one poured a nice, although slightly overly clear/filtered honey color with a reasonable head....Thick lacing on the glass.
Smell is subtle, a bit too subtle for an american wheat.
The taste is great, a nice balance of lemony hops (Sorachi?) and a clean wheaty taste. Very pleasant and assertive with the hops..
The best one I've tried from their brewery thus far.
Serving type: bottle
09-23-2011 22:52:04 | More by jbonapar
Quebec (Canada)
3.83/5 rDev -2.8%
look: 3.5 | smell: 4 | taste: 4 | feel: 3.5 | overall: 3.5
Thanks to TheSevenDuffs for this one.
Poured from a 650ml. bottle (love the label!) and shared with my wife.
Appearance: Mountains of foam (4-5 fingers) than settles to less than 2 before disappearing. Body is a dirty yellow, like hay.
Smell: Hops, tangerine, citrus rinds and grapefruit.
Taste: Pink grapefruit, lots of citrus and almost no wheat. Bitterness is sustained but it feels like one note.
Mouthfeel: Prickly carbonation, strong upfront but doesn't carry through in the end. In like a lion, out like a lamb...
Overall: Taste like it smells which is hops. Not really a wheat ale. I sound like i'm ragging on it but i did enjoy it. It's just short of great.
Serving type: bottle
09-18-2011 00:05:42 | More by papat444
Ontario (Canada)
4.03/5 rDev +2.3%
look: 4.5 | smell: 4 | taste: 4 | feel: 4 | overall: 4
650 ml bomber poured into a weizen glass.
A: Pours a cloudy gold with 3 fingers of fluffy eggshell head; good retention and sticky lacing.
S: Smells of sweet citrus hops (tangerine), maybe a bit of pineapple, no banana!
T: Taste is very dry, tart (lemon?) and bitter. Very refreshing and would be a great summer quaffer.
M: Light-medium body with fairly prickly carbonation.
D: The drinkability is very high.
Serving type: bottle
09-16-2011 03:22:53 | More by mrnobody
Quebec (Canada)
3.93/5 rDev -0.3%
look: 3.5 | smell: 4 | taste: 4 | feel: 3.5 | overall: 4
Bottle: Poured a clear golden color ale with a nice foamy head with good retention and some lacing. Aroma of citrus and bitter hops is a bit surprising and leaves little room for the wheat notes. Taste is a mix between some citrus and piney notes with quite a bitter character mix in with a pale wheat malt base. Body is about average with good carbonation. Not as much wheat malt as I would have liked but nice too see a light beer with loads of character.
Serving type: bottle
09-12-2011 19:16:35 | More by Phyl21ca
Ontario (Canada)
4.03/5 rDev +2.3%
look: 4.5 | smell: 4 | taste: 4 | feel: 4.5 | overall: 3.75
From notes.
A - Poured a golden colour that was bright and very effervescent. Three finger fluffy white head with sticky lacing and a half finger of retention.
S - Straight hops. Citric and slightly spicy with lemon and grapefruit coming through in a big way.
T - Very aggressive with the hops. No sign of yeast or wheat. Simply hops to me. Citrus and resinous, less spicy.
M - Light body with a fairly bitter finish and strong carbonation. Really, really smooth.
O/D - A little confused on the wheat aspect. It's very, very hop forward. A nice take on a typically boring style but maybe over-hopped? Either way I liked it.
Serving type: bottle
09-10-2011 23:21:17 | More by tbeckett
Ontario (Canada)
4.03/5 rDev +2.3%
look: 4.5 | smell: 4 | taste: 4 | feel: 4 | overall: 4
650 ml bomber.
Part of the LCBO's Ontario Craft Brewery one-off feature.
Limited availability.
Pours a clear yellow golden with a finger of white fluffy head. Nose is ripe with grapefruit, citrus and floral hops. Crisp, clean aroma - only slight evidence of a malt & pale profile.
Taste is a pale yeast and caramel malt base with a dash of pacific hops adding a dry bitter aftertaste. Alot of flavour for such a low ABV. Drinks like a sessionable pale ale, decent amount of hop profile to keep anyone happy.
Overall, this is not a weiss in the slightest, as the name suggests, but rather a very similar build to Great Lakes Crazy Canuck Pale that recently came out in cans, but packed with a greater session potential. I don't particularly like the name choice or marketing around it / label though, but the beer itself is spot on - and thats what matters.
Serving type: bottle
09-05-2011 21:06:54 | More by heebes
Ontario (Canada)
4.03/5 rDev +2.3%
look: 4.5 | smell: 4 | taste: 4 | feel: 4 | overall: 4
Beer is golden in colour. Moderately cloudy, but not as much as many wheat beers. A big, thick and sticky white head is on top. Great lacing, very good retention.
Nose is full of grapefruit, lemon, tangerine. Smells more like an IPA than a wheat, but the crisp wheat scent is present as well. Nice smell.
Taste is similar to the nose, but the citrusy elements are toned down a bit in comparison to the wheat aspects. Still tastes more like an IPA than a hefeweizen, but both are recognizable. Grapefruit, lemon- a really juicy flavour, fairly bitter.
Medium bodied, moderate carbonation. Juicy body.
Very nice beer. Much hoppier than I expected, and not very similar to a weisse. An unusual beer in my experience, and a success. I would like to see this be a regular offering from Great Lakes.
Serving type: bottle
09-04-2011 19:32:34 | More by jrenihan
Ontario (Canada)
4.05/5 rDev +2.8%
look: 4 | smell: 4.5 | taste: 4 | feel: 3.5 | overall: 4
Pours a golden pencil yellow colour with a soapy white head that leaves behind a generous lace and small collar. Very fine rust-coloured sediment can be seen suspended in the brew.
Smells of butter, honey, toasted wheat, flowers and tangerine. Very bright and fresh smelling.
Toasted wheat malts are followed by a tart grapefruit citrus tang and a subtle cherry tone, with a slight earthiness in the finish.
Feels a tad yeasty on the tongue and it's a bit thin, but it does have a certain sparkle to it, along with a dry and somewhat bitter aftertaste.
Reminds me of a hopped-up version of their Orange Peel Ale or, as others have noted, a lighter take on Crazy Canuck. Regardless, it's smooth, tasty and a bit creamy. Would make this a go to beer if possible. Paired well with both red sauce and peppery kettle chips.
Serving type: bottle
09-04-2011 01:52:36 | More by bryehn
Ontario (Canada)
3.73/5 rDev -5.3%
look: 4 | smell: 4.5 | taste: 3.5 | feel: 3.5 | overall: 3.5
Bottle in Unibroue glass
Appearance: 4
Golden yellow brown, with 1 inch white head, moderate lacing, mild to medium retention of the head.
Smell: 4.5
Tropical fruits from the hops – mango, tangerine, pineapple, with a little grapefruit. Just great smell.
Taste: 3.5
A little one dimensional. A small amount of sweetness from malt, but really pure bitterness from hops without any fruity notes. Finishes with a cutting bitterness. Body feels pretty light, probably because of low alcohol content. Definitely a hop head beer. Flavor softens overall together as beer warms, but tends to be very bitter.
Mouthfeel: 3.5
Mild to moderate thinness, and quite astringent from the hops.
Overall: 3.5
Really interesting beer. It has an amazing aroma, but doesn't match with taste. Its definitely not like a typical Weiss beer, instead its is more like a west coast ipa. It is hard to figure which style and expectations to have. Would enjoy if it had a stronger malt presence in the taste. Also interesting is the low alcohol content which hinders the taste profiles, but makes it easy to enjoy without effects of alcohol. Overall, would enjoy more with tweak to malt content, but for a one off beer, still quite enjoyable.
Recommend trying.
Serving type: bottle
09-04-2011 00:18:11 | More by EnemyWithin
Ontario (Canada)
4/5 rDev +1.5%
look: 4 | smell: 4 | taste: 4 | feel: 4 | overall: 4
650ml Bottle
Appearance – Slightly hazy amber colour with a large size frothy and fizzy beige coloured head. There is a low amount of carbonation showing and there is a good amount of lacing. The head lasted for around 5 minutes before it was gone.
Smell - Malts, hops, caramel, grapefruit/oranges
Taste & Mouth - The beer has an average amount of carbonation and I can taste malts, caramel, and a fair amount of hops. As well, there is a huge blast of citrus. Lemons, grapefruits, and oranges.. all great just not what i was expecting when I bought a wheat beer. (I didn't read the blurb on the back of the bottle) It finishes with a hoppy citrus aftertaste.
Overall – If you like west coast IPA's, then you will like this 'wheat' beer for sure. As someone esle stated, it kind of like a lightened up Crazy Canuck.. maybe with a tough more citrus. It actually reminded me of the Lagunita's Lil Sumpin Sumpin pale wheat ale. Anyways, it's a tasty beer that I will buy a few more bottles of for sure.
Serving type: bottle
09-02-2011 12:24:18 | More by spinrsx
Ontario (Canada)
3.95/5 rDev +0.3%
look: 4.5 | smell: 5 | taste: 3.5 | feel: 3.5 | overall: 4
Pours a caramel gold topped by a bright, white, thick and moussey head with just a bit of a haze. Laces nicely.
Really nice clean citrus aroma with caramel and hint of tropical fruit. Smells more like an APA than a wheat beer.
Sweet rounded malts in the middle are washed away by a grassy bitterness. Lemon herbalness throughout. A bit of honey sweetness underneath with some tropical fruit on the far-flung edges. Finishes long with the bitterness just about outstaying its welcome in the aftertaste. An argument could be made that this could use less hop bitterness and more hop flavor, but it's still pretty good as is.
Mouthfeel is medium, crisp carbonation. Seems a tad under-attenuated.
It tastes to me like they lighted up Crazy Canuck Pale Ale with some wheat. That's not necessarily a bad thing. Canuck's a fine beer. And so is this. But there's much better value in the Canuck for me.
Serving type: bottle
08-31-2011 00:55:13 | More by MeisterBurger
Ontario (Canada)
4.1/5 rDev +4.1%
look: 4 | smell: 4.5 | taste: 4 | feel: 4 | overall: 4
A - poured a huge two finger fluffy white head with plenty of lacing - nice cloudy golden orange colour - this seems to be the only "weiss" characteristic with this one
S - huge hops scent dominates here - a wee bit of wheat - citrus fruit
T - pine, grapefruit, spicy, pineapple, herbal/mdeicinal towards the end
M - light body with plenty of carbonation - spicy and bitter
O - this was a real surprise - glad I read the warning on the label "this is not a weiss..." - closer in taste to a hoppy IPA -will definitely grab more of this while it is available
Serving type: bottle
08-30-2011 07:56:57 | More by Stocean1
Ontario (Canada)
4.33/5 rDev +9.9%
look: 4 | smell: 4 | taste: 4.5 | feel: 4 | overall: 4.5
A stunning amount of "west coast" hop flavour in this 4.5% ABV pint.
Enjoyed this first from a cask at the brewery last year and on draught several times since, including this afternoon at BeerBistro, after purchasing the first bottles I've ever seen at the brewery.
A clear golden, rusty amber with white foam and decent carbonation. Aroma is pure "c" hop, as is the flavour. Some caramelized malts in the taste as well, with its pleasantly crisp and bitter finish.
Although this is a wheat beer, I am delightfully surprised by how little wheat evidence I can taste. Realize this style is both traditional and popular, but just not to my personal taste. Great Lakes has created the perfect summer beer for anyone who shares my indifference to wheat and love of hoppy ales!
Serving type: on-tap
08-28-2011 22:19:37 | More by hopsolutely
Ontario (Canada)
3.8/5 rDev -3.6%
look: 4.5 | smell: 4 | taste: 3.5 | feel: 4 | overall: 4
Bottle from the brewery, originally inspired by the Project X creation from a ways back. 650ml into a tulip.
Pours a mildly hazy orange-yellow, with a nice fat white head atop. Huge sticky lace and fantastic retention. Nose is huge orange and citrus notes, Amarillo distinctly. Some light pine, and peripheral honey and wheat notes are slightly detectable. Touch of peach and tropical fruitiness. Taste is more recognizable as a pale wheat ale, as big wheat notes hit the palate with a continued hop presence as per the nose - more orange and a touch of peach. Dry, grainy and wheaty. Body is quite light and there's some moderate carbonation here, some bitterness in the finish and a definite drying sensation. Some chewiness. Nice stuff, and quite drinkable at the ABV. An interesting cross between what feels like a pale wheat ale and a lighter IPA. Glad I've got a few more in the fridge.
Serving type: bottle
08-22-2011 02:46:46 | More by liamt07
Ontario (Canada)
4.33/5 rDev +9.9%
look: 4 | smell: 4 | taste: 4.5 | feel: 4 | overall: 4.5
On tap at Beerbistro
Poured a cloudy yellow/orange colour with two fingers of creamy white head.
Crisp bitter cirtus hops on the nose with grapefruit and orange notes.
The taste follows the nose with crisp bitter citrus hops that have hints of grapefruit and tangerine. Very little in terms of wheat ale characteristics in this one, just tastes like a straight up pale ale. There is a bitterness that lingers in the finish with this one, which becomes a little bit too noticeable as I continue to drink this.
Light body, light mouth feel.
An excellent beer. Reminds me of FFF Gumballhead and almost the same quality.
Serving type: on-tap
08-23-2010 03:11:45 | More by TheSevenDuffs
Ontario (Canada)
3.93/5 rDev -0.3%
look: 3.5 | smell: 4 | taste: 4 | feel: 3.5 | overall: 4
Had a 8oz glass at the session craft beer festival.
Looks like an average Hefe Weisen nothing spectacular in terms of looks, unfiltered so its nice and cloudy. The smell is out of this world thick with yeast and exploding with hops smells more like an IPA that a Hefe weisen, blew me away in that category. The taste is where this comes to shine. Has all the citrus and spice notes typical of a wheat beer but with a generous hop kick. Very easy to drink excellent beer for the season even though it was raining at this particular morning (the sun did come out when they started pulling the cask of My Bitter Wife though) I hope they keep brewing this.
Get a pint if you see this on tap. This is truly a wheat beer for the IPA lover.
Serving type: bottle
07-17-2010 04:41:12 | More by peensteen
British Columbia (Canada)
3.98/5 rDev +1%
look: 4 | smell: 4.5 | taste: 3.5 | feel: 4 | overall: 4.5
I've had this a few times now... about time I reviewed it.
A: Hazy, golden bronze, white head, good retention lace.
S: Huge amarillo hop aroma with some nice tropical fruity esters.
T: Plenty of leafy hop goodness, but I think it could use a touch more 'flavour' hops to round it out. It just doesn't have the same depth as a Gumball head. Good bitterness.
M: Smooth, moderate body has a light acidity and a dry finish.
D: Hell of a drinker.
This is a great American wheat, and a very sessionable strength.
Serving type: bottle
07-06-2010 00:33:36 | More by Derek
Quebec (Canada)
3.65/5 rDev -7.4%
look: 4.5 | smell: 4 | taste: 3.5 | feel: 3.5 | overall: 3.5
Bottle picked up recently from the brewery. This stuff pours beautifully, with no shortage of rocky meringue-like head. I'd say this beer ties with Dennison's Weisse for best head in Ontario. I guess that's fairly typical for bottle conditioned beers. The body is opaque and a dull-straw colour. Great retention and tons of lacing.
The nose almost lives up to the appearance with loads of banana, lemon rind, pineapple, guava, celery, light caramel and spice. This actually smells fairly similar to Schneider's Hopfen Weisse, recently released by the LCBO.
The flavour is a bit of a let down, to be honest; but only given the expectation set up here. There's a pretty solid grassy bitterness, but it's not completely balanced out by anything else; sort of left on its own. There's not really much weisse character coming through, it almost comes off as a hoppy pale ale lacking in malt. Under the hops is some light grain and a pepperiness (celery-like) but no significant malt. The finish leaves some lingering, drying herbal bitterness. This one could definitely use some tinkering. I like the hops but there needs to be more of everything else. All that said, it's not too too bad.
The feel sort of average: light-medium body and moderate carbonation.
I can't remember having tried many beers where the appearance and nose were so far off from the quality of the taste. Strange. They have you expecting an amazing beer only to find a mediocre one. Still, it's pretty drinkable. I'd be interested to try a reworked version of this beer. Otherwise, I don't think I'll be picking it up again.
Serving type: bottle
07-04-2010 05:24:43 | More by eat
Ontario (Canada)
3.75/5 rDev -4.8%
look: 3.5 | smell: 4 | taste: 3.5 | feel: 4 | overall: 4
On tap at C'est What Spring Festival.Unfiltered grapefruit look, with white lacing. Good grapefruit aromas. Wheaty hoppy beer. Decent mouthfeel and taste, drinkability. Like the Imperial HefeWeiss, just a step down. However the continued upward trend for the brewery.
better in most recent bottling, with creamier mouthfeel and more apparent bitterness.
Even better on cask at the LCBO public release. Orange aroma, smooth not not thick. Much carbonation for a cask.
Serving type: on-tap
05-30-2010 19:53:08 | More by Sammy
Ontario (Canada)
3.83/5 rDev -2.8%
look: 4 | smell: 4.5 | taste: 3.5 | feel: 3.5 | overall: 4
Bottle: I'm told this is bottle conditioned but I assume this is cask brew finished in the bottle rather than the a cask.
Pours a cloudy golden ale in the flute with a solid puffy cap...great lacing. Nice soft natural carbonation. Aroma is unique for a Weizen this has a pungent bouquet of fruity esters mingled with PNW hops; exotic fruits-banana-citrus...light biscuit aroma. Soft mouth feel... biscuity, citrus resinous hopping, dry citrusy finish. Bright flavors but not the fruit basket the aroma promised...lacking spice phenols.
I got a couple of these and I suspect as a bottle conditioned weiss it may take a couple more weeks to have all the flavors develop. I'll sample it again then.
Serving type: bottle
04-21-2010 23:47:49 | More by pootz
Ontario (Canada)
3.73/5 rDev -5.3%
look: 4 | smell: 4.5 | taste: 3.5 | feel: 3.5 | overall: 3.5
First bottle conditioned beer in Ontario (to the best of my knowledge), so this is quite the coup for Great Lakes. It was originally brewed for a Project X cask night that I missed, but fortunately they bottled some only last week. From what I've heard it was intended as the brewery's take on Gumballhead, so I'm expecting a hopped-up beast that transcends the style guidelines.
Hazy amber body with a creamy white head that puts down some good streaks of lace. Awesome nose - resinous and fruity with strong pine, mango, pineapple and tangerine notes. Really a great one to breathe into. Flavour is decent, but can't live up to the heights of the aroma. A slightly generic bitterness takes on a leafy nature, and the fruit drops out almost completely, though light pineapple flits in and out. Strong malt and wheat backbone provides support and substance. Medium body and carb.
Pretty decent, and a nice drinker, though it misses out on the top tier by struggling to deliver on the promise of the aroma. I like the direction these guys are heading though, and not many Ontario brewers are willing to up the bitterness as high as it is here.
Serving type: bottle
04-19-2010 13:31:50 | More by bobsy
Great Lakes Miami Weiss from Great Lakes Brewery
out of 100
based on 68 ratings.


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Calcineurin Inhibitor (CNI)-Free Immunosuppressive Regimen in T1D Patients Receiving Islet Transplantation (ECIT-1)
This study is ongoing, but not recruiting participants.
Ospedale San Raffaele
Juvenile Diabetes Research Foundation
Information provided by (Responsible Party):
Piemonti Lorenzo, Scientific Institute San Raffaele
ClinicalTrials.gov Identifier:
First received: April 29, 2011
Last updated: October 3, 2012
Last verified: October 2012
- Full Text View
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- How to Read a Study Record
Our final objective is to develop an adoptive therapy with tolerogenic donor-specific Tr1 cells in T1D patients undergoing pancreatic islet transplantation (Tx). The achievement of this objective depends by the availability of an immunosuppressive treatment (IS) compatible with the survival, function, and expansion of the transferred Tr1 cells. For this purpose the investigators design a CNI-free single-group, phase 1-2 trial excluding the ATG or anti-CD25 induction therapy after the 1st islet infusion
Condition | Intervention | Phase |
Type 1 Diabetes |
Drug: CNI free immunosuppression |
Phase 1 Phase 2 |
Study Type: | Interventional |
Study Design: | Endpoint Classification: Safety/Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | A Multi-step Trial Towards Single Donor Islet Transplantation in Type 1 Diabetic Patients, Using Calcineurin Inhibitor-free Immunosuppression |
Resource links provided by NLM:
Further study details as provided by Ospedale San Raffaele:
Primary Outcome Measures:
- the proportion of insulin free patients one and two years after the 1st islet infusion [ Time Frame: years 1 and 2 ] [ Designated as safety issue: No ]Insulin independence is defined as no need for exogenous insulin, with adequate glycemic control [i.e., glycated hemoglobin <6.5% (normal range 3.5 - 6.0%), fasting glucose levels not exceeding 140 mg/dL (7.8 mmol/L) more than three times per week and 2-hour postprandial levels not exceeding 180 mg/dL (10 mmol/L) more than four times per week].
Secondary Outcome Measures:
- insulin independence with adequate glycemic control throughout follow-up [ Time Frame: up to 3 years ] [ Designated as safety issue: No ]
- glycated hemoglobin levels throughout follow-up [ Time Frame: up to 3 years ] [ Designated as safety issue: No ]
- basal and stimulated blood C-peptide levels in response to arginine challenge throughout follow-up [ Time Frame: up to 3 year ] [ Designated as safety issue: No ]
- the reduction in insulin requirement compared to baseline [ Time Frame: up to 3 years ] [ Designated as safety issue: No ]
- severe hypoglycemic events since completion of transplant [ Time Frame: up to 3 years ] [ Designated as safety issue: Yes ]
- Any adverse event throughout follow-up [ Time Frame: up to 3 years ] [ Designated as safety issue: Yes ]
Enrollment: | 10 |
Study Start Date: | October 2006 |
Estimated Study Completion Date: | April 2013 |
Estimated Primary Completion Date: | April 2013 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: CNI-free single-group |
Drug: CNI free immunosuppression
Immunosuppression consisted of: (i) pre-Tx rapamycin treatment (0.1 mg/kg/day) for at least 30 days; (ii) induction therapy with ATG (1.5 mg/kg/day for 4 days starting at day -1) and a steroid bolus (methyl-prednisolone 500 mg, day -1) plus low dose steroids (prednisone, 10 mg/day) and interleukin-1 (IL-1) receptor antagonist (100 mg/day) for 2 weeks (with ATG and steroid bolus administered only prior to the 1st islet infusion; (iii) maintenance with rapamycin (0.1 mg/kg/day) plus mycophenolate mofetil (2 g/day).
Other Name: Kineret, Rapamune, Thymoglobulin, Myfortic
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Male and female patients aged 18-65yr
- ability to provide written informed consent and comply with the study protocol procedures
clinical history of type 1 diabetes with onset <40yr of age, on insulin for
- 5yr at the time of enrollment
- absent stimulated C-peptide (<0.5ng/ml) in response to arginine
- multiple (three or more) daily insulin injections or insulin pump therapy
- self blood glucose monitoring ≥3 times/day, supervised by a specialist physician
- high glycemic instability and hypoglycemia unawareness
- inability to consistently attain a HbA1c < 7.5 % target without experiencing severe hypoglycemia (assistance by another person) in the past 36 months despite appropriate medical management.
Exclusion Criteria:
- HbA1c >12%
- BMI >30 kg/m2, or insulin requirement of > 0.8 IU/kg/day;
- poorly controlled hypertension;
- untreated proliferative diabetic retinopathy;
- presence or history of macroalbuminuria (>300mg/g day) or measured glomerular filtration rate <70 ml/min/1.73 m2 for females and <80 ml/min/1.73 m2 for males
- for female participants: positive pregnancy test, presently breast-feeding, or unwilling to use effective contraceptive measures for the duration of the study and 3 months after discontinuation
- for male participants: intent to procreate during the duration of the study or within 3 months after discontinuation or unwillingness to use effective measures of contraception;
- any history of malignancy within the previous 5 years, except for completely resected squamous or basal cell carcinoma of the skin;
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01346085
Italy | |
IRCCS San Raffaele | |
Milan, Italy, 20132 | |
Switzerland | |
Universitè de Geneve | |
Geneve, Switzerland, 1211 |
Sponsors and Collaborators
Ospedale San Raffaele
Juvenile Diabetes Research Foundation
Principal Investigator: | Lorenzo Piemonti, MD | Fondazione Centro San Raffaele del Monte Tabor | |
Principal Investigator: | Thierry Berney, MD | Universitè de Geneve | |
Study Chair: | Antonio Secchi, MD | Fondazione Centro San Raffaele del Monte Tabor | |
Study Director: | Paola Maffi, MD | Cantro San Raffaele del Monte Tabor |
More Information
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by Ospedale San Raffaele:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 11, 2014
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Piemonti Lorenzo, Director Islet Transplantation Program, Scientific Institute San Raffaele |
ClinicalTrials.gov Identifier: | NCT01346085 History of Changes |
Other Study ID Numbers: | ECIT-1 |
Study First Received: | April 29, 2011 |
Last Updated: | October 3, 2012 |
Health Authority: | Italy: Ministry of Health |
Keywords provided by Ospedale San Raffaele:
islet transplantation brittle diabetes type 1 diabetes |
Additional relevant MeSH terms:
Diabetes Mellitus Diabetes Mellitus, Type 1 Glucose Metabolism Disorders Metabolic Diseases |
Endocrine System Diseases Autoimmune Diseases Immune System Diseases |
ClinicalTrials.gov processed this record on March 11, 2014


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#40 to #39
Hreidmar ONLINE (03/05/2013) [-]
My sympathies. You should come over to my college. I recently had to patch up an out-of ***** dissection, by which I mean some idiots decided to fence with beer bottles. I think you would have appreciated the opportunity to find out what makes their stupidity tick.
#42 to #41
Hreidmar ONLINE (03/05/2013) [-]
Einstein was useful to the world. Even if he was missing some gray/pinkish matter, he certainly didn't let it hold him back. These two don't either, in all the wrong ways. It's not the first time I stitch them up.
You should pressure your biology department to live up to it's reputation. Dissections are rather important, after all. Not to mention... entertaining.
You should pressure your biology department to live up to it's reputation. Dissections are rather important, after all. Not to mention... entertaining.
#43 to #42
DrollHumor ONLINE (03/05/2013) [-] I'm more concerned about the fate of my chemistry lab partner if he continues to ignore proper measurements and instruments. For my percent error report I have to resist the urge to just write his name in big bold letters.
#139 to #15
paraplegichedgehog (03/06/2013) [-]
i'm never one to openly disagree with someone's point of view, let's just say that i appreciate the fact that he has enough emo background story to make him fit in completely and utterly within the Naruto universe but the fact that he presents zero ***** about his history makes him cool and kinda quirky in my option


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For dinner I would choose Chef Mickey's, but hit Crystal Palace for lunch!
For dinner I would choose Chef Mickey's, but hit Crystal Palace for lunch!
I personally like Chef Mickey's because you see the big guys - Mickey, Minnie, Goofy, Chip and Dale and Donald. We took 11 people over Thanksgiving and still got lots of personal attention from all of them. My kids loved it! (Of course the adults did too!) lol!
If you are on a budget, I would say a late lunch/early dinner at Crystal Palace. With it being a buffet, you can get there are 4:00 and eat until you are silly! Then get a Dole Whip and a Churro later for a snack and you are all set!!!!!
Did both of them the same week last summer. The food at Chef Mickey's for dinner was very good. It is also a buffet, and we thought it was better than most. We were less impressed with the food at Crystal Palace.
-Pat (Disneydame2004)
Dream Team Auction Coordinator
Help make a child smile! Dream Team Project Firstgiving Page
I would go with Chef Mickey's.
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CONCACAF Champions League Refresher
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Lockport is located in Illinois. Lockport, Illinois has a population of 24,839. Lockport is more family-centric than the surrounding county with 44.67% of the households containing married families with children. The county average for households married with children is 41.96%.
The median household income in Lockport, Illinois is $70,904. The median household income for the surrounding county is $72,067 compared to the national median of $50,935. The median age of people living in Lockport is 34.2 years.
The average high temperature in July is 85 degrees, with an average low temperature in January of 13.8 degrees. The average rainfall is approximately 35.4 inches per year, with 17 inches of snow per year.
Koenig & Strey Real Living 4709 Golf Road, Suite 1100 Skokie, IL 847-853-6670 Real Estate Agents & Staff


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Posted: 6:15 p.m. Monday, Nov. 22, 2010
By Jamie Dupree
On Tuesday, President Obama and Vice President Biden go to Kokomo, Indiana, where they will tout gains under the controversial economic stimulus law. The White House issued the following "background" press release on the Obama-Biden trip. You can review the Obama Administration claims and leave your own review of the stimulus.
The White House
Office of the Press Secretary
November 22, 2010
On Tuesday, November 23, 2010, President Obama and Vice President Biden will take their White House to Main Street Tour to Kokomo, Indiana, a community that is turning the corner, in part as a result of innovative investments from the American Recovery and Reinvestment Act, as well as the Obama Administration's auto industry restructuring plan. Kokomo is leveraging opportunities from the Recovery Act to not only provide much-needed economic relief for middle class families, but to invest in new, sustainable industries and technologies. During the visit, the President and Vice President Biden will visit Indiana Transmission, a Chrysler plant in Kokomo.
President Obama last visited Kokomo, Indiana in April 2008. As part of that visit, he held a town hall meeting where he discussed recent layoffs in the community and called for new investments in clean energy, manufacturing and education to help bring secure, well-paid jobs to places like Kokomo.
In recent years, Kokomo, a midsized industrial town in north central Indiana, was hard-hit by devastating plant closings and layoffs. In late 2007, Kokomo Sanitation Pottery closed, laying off nearly 100 workers. And when Chrysler laid off over 11,000 workers nationwide in 2007, Kokomo lost even more jobs. In mid-2008, hundreds of manufacturing jobs were lost at the local Delphi plant. By the end of 2008, Kokomo had been labeled one of "America's Fastest Dying Towns" because of the sharp decline in local manufacturing and auto jobs. Unemployment hit over 20 percent in 2009, making Kokomo's one of the highest unemployment rates in the country.
With the help of the Recovery Act and the Administration's auto restructuring plan, along with smart investments by the mayor that subsequently leveraged additional private capital, Kokomo is on the rebound today. Unemployment is down nearly 8 percent to 12 percent as of September 2010 and the downtown has experienced significant revitalization. Kokomo is a key example of how federal government investments, when used wisely, can work together to impact an entire community.
Kokomo Mayor Greg Goodnight was able to leverage hundreds of thousands of dollars in Recovery Act funds to help revitalize the downtown. Since then, about a dozen new small businesses have opened in downtown Kokomo over the last year.
The city also significantly benefited from auto restructuring. According to recent press coverage, "without the federal auto bailout, many feel 3,500 workers in Kokomo would have lost their jobs." And according to the Mayor, Chrysler's presence in the city helps them generate about $18 million a year in property taxes. Had Chrysler gone under, the city would have suffered an enormous economic setback.
has received more than $8.4 billion in Recovery Act funds. As a result, the
Council of Economic Advisors estimates that the Recovery Act is already
responsible for 71,000jobsin Indiana through September 2010. To
date, more than $6.2 billion of this funding has been spent. These dollars and
awards to come will continue to support even more jobs in Indiana in the months
Without the steps the President took, Chrysler would have liquidated resulting at least a million jobs lost for workers across the country, including in Kokomo. Now, just over a year later, Chrysler is returning to profitability, hiring workers, keeping plants open. And because of the steps the Administration has taken with Cash for Clunkers and the Recovery Act, the industry overall is strengthening - including America's auto dealers.
The Chrysler plant the President and Vice President will visit in Kokomo on Tuesday received a $343 million private investment in June 2010 to retool and modernize its Kokomo transmission plant, which has helped to retain more than 1,000 workers this year for the production of a future eight-speed automatic transmission. According to the Kokomo Tribune, Chrysler has recently recalled 400 employees that were previously laid off as a result.
A new report, released last week by the Center for Automotive Research in Ann Arbor, Michigan, estimates that the President's efforts saved over 1.14 million jobs overall, and averted $28.6 billion in costs to the government. Over the past year and a half, the auto sector has rebounded: industry employment has increased nearly 10 percent, and each of the big three - Ford, General Motors, and Chrysler - is operating at a profit.
Overall, the Kokomo area has received over $400 million in direct Recovery Act funding for a variety of programs and projects. These projects represent vital investments in the local community, including:
· Delphi Automotive, a Michigan based company, was awarded over $89 million from the Department of Energy to expand manufacturing capacity of passenger and commercial hybrid vehicles components. The "new" Delphi, with the help of the Recovery Act, is beginning to manufacture circuit boards that control hybrid vehicles, otherwise known as the "brains of a hybrid vehicle."
o The Recovery Act is responsible for nearly 60 jobs to date at Delphi and in total will enable the company to retain and hire nearly 200 additionalworkers as production of the hybrid vehicles parts ramp up over the next several years.
o Delphi currently supplies power electronics components such as inverters, chargers, and DC/DC converters to production hybrid vehicles from manufacturers, such as GM, Ford, Daimler, and BMW.
o As a result of this grant, Delphi already has agreed to supply power electronics to GM, Allison Transmission, and Coda Automotive.
o Production began in July and Delphi began shipping products to customers in August.
· In his July 4, 2010 radio address, President Obama announced a conditional offer of $400 million from the Department of Energy's 1705 loan guarantee program for Colorado-based thin film solar PV manufacturer Abound Solar. Abound will use nearly $300 million of the loan guaranteed to open a new plant in an empty Chrysler supplier factory just 20 miles outside of Kokomo, in Tipton, IN. Construction will begin on the Tipton plant in early 2012 and Abound plans to hire 900 workers at the plant once it's up and running. The loan, which is expected to close by the end of the year, will not only enable Abound drive additional economic activity across the industry and down the supply chain, but will also help establish U.S. leadership in cutting edge solar technology around the world. The project represents the first time new manufacturing technology for Cadmium-Telluride panels is deployed commercially anywhere in the world. Ninety percent of Abound's product is being exported abroad to places like Germany, Italy and the United Kingdom.
· Kokomo Mayor Goodnight is using $214,600 in Energy Efficient Conservation Block Grant (EECBG)funds from the Department of Energy to install energy-efficient lighting in Foster Park, along Kokomo's "Walk of Excellence" and to retrofit parts of City Hall. This funding is contributing to the revitalization in downtown Kokomo that has helped to lure nearly a dozen new small businesses in the last year.
· In addition to the new lighting downtown, the City is also replacing sidewalks and curbs throughout neighborhoods in Kokomo with $265,700 in Community Development Block Grant (CDBG) funding from the Department of Housing and Urban Development. HUD also provided over $1 million from in Public Housing Capital Funds to improve and modernize various public and low-income housing developments in Kokomo. The Kokomo Housing Authority reported hiring 5 new workers and retaining 38 additional workers as a direct result of the Recovery Act.
· Mayor Goodnight was also able to hire 5 new police officers with over $1 millionfrom the Justice Department's Community Oriented Policing Services (COPS) program. DOJ also provided $200,000 in Byrne Justice Assistance Grant funds to the City of Kokomo.
· Howard County, where Kokomo is located received over $17 million in Recovery Act funding from the Department of Transportation, including:
o $11.4 million for the Kokomo Bypass (Route 31), which is being use to improve and realign the highway and upgrade several bridges along the route. This section of roadway is part of a $345million, 14-mile project that is part of the Indiana Governor's Major Moves program. The Recovery Act-funded section of the bypass project is 95 percent complete. The contractor is Primo, Inc., and the project has created approximately 49 jobs to date.
o Over $2 millionto rehabilitate Dixon Roadand add additional travel lanes. This major local project is still underway, even though construction has ended for the season.
o Over $1 million for other resurfacing projects including 18 locations on Routes 400N, 750W, and 100N in Howard County, all of which were finished in late 2009.
o Over $1 millionfrom the Federal Transit Administration to purchase and renovate an existing building in downtown Kokomo to be used for both for transit operations for the City's paratransit system, the Spirit of Kokomo, and for the administration of the local metropolitan planning organization (MPO). The project is halfway completed, and created 34 jobs last quarter.
· The Department of Education provided the Kokomo-Center Township Consolidated School Districts with over $12 million in Recovery Act funding, including:
o Over $5 million in State Fiscal Stabilization Funds (SFSF) to fill budget gaps;
o Nearly $5 million in IDEA funding for students with disabilities;
o $1.7 million to expand Kokomo's existing Head Start and Early Head Start programs; and
o Over $1.5 million in Title I funds to improve schools in the district.
· The Department of Education also provided $1 million in Pell Grants to colleges and universities in Kokomo to increase access to higher education.
o Approximately 30,000 students in Indiana are benefiting from increased Pell Grants as a result of the Recovery Act.
o That total includes approximately 125 students in Kokomo alone.
· The Small Business Administration (SBA) supported 14 loans for small businesses in the Kokomo area totaling $7.3 million including:
o Gingerbread House Bakery: Lauren Gaines and her husband received a $140,000 loan through the Recovery Act to purchase the Gingerbread House Bakery. Thanks to the Recovery Act loan, they were able to save about $2,500 in fees. This loan enabled them to take over the former donut shop and make it their own. Since then, business has been booming. This loan was the only way Lauren and her husband could have started the business. They currently have 4 people on their payroll and expect to expand. The Gingerbread House Bakery has evolved and, while it still specializes in donuts, it now also makes traditional baked goods, cookies and cakes on special order and specialty treats during the holidays. Lauren reports the bakery has been increasingly busy since opening last December 1st. They expanded the kitchen in April to meet demand and they hope to expand and build another building in the next six months.
o Stephens Machine Inc., which is a Kokomo-based machine shop that received two SBA loans through the Recovery Act ($487,000 and $375,000). The company has two local facilities totaling more than 45,000 square feet where they engineer, design and build automated production machinery, do tool and die work and produce prototypes used for research and development. They've already reported 12 new jobs as a result of the Recovery Act loans.
o Blondie's Cookies, which received an $890,000 SBA loan through the Recovery Act and report creating 30 new jobs as a result of it. The company was started in 1984 when the owner was a student at Indiana State University and has 11 locations in malls around Indiana, including one in Kokomo's Markland Mall. They hope to add two to three more locations in Indiana, as well as expanding to other states.
o Coldline Manufacturing, which is a Kokomo-area business that is using an $80,000 Recovery Act SBA loan to revamp their business plan from manufacturing refrigerated trailers to custom auto parts and metal fabrication. As a result of their shift in strategy, they have been able to hire several new part-time workers and have saved $1,440 in fees with the loan.
Total Jobs & Spending
- CEA estimates that 71,000jobswere created or saved by
the Recovery Act in Indiana through September, 2010.
· TOTAL SPEND - More than $8.4 billion in Recovery funds has been made available to Indiana - and over $6.2 billion has already been spent.
Investing in Infrastructure
· INFRASTRUCTURE: Over $1.3 billion has been obligated for 1320 infrastructure projects in Indiana, funding 2,400 jobs through September, 2010.
· TRANSPORTATION- Over $807 million has been obligated for 1,161 transportation projects in Indiana.
· SMALL BUSINESS - 1,536 Recovery Act SBA-backed small business loans have been given to Indiana small businesses, supporting more than $584 million in lending.
Relief to Individuals
· TAX RELIEF - Because of the Making Work Pay tax credit, 2,400,000 Indiana working families will collectively receive $1.3 billion in tax relief.
· UNEMPLOYMENT BENEFITS- More than 580,000 Indiana residents have expanded unemployment benefits because of the Recovery Act.
· STIMULUS PAYMENTS - More than 1.1 million Indiana seniors, veterans and other high-need residents have received one-time economic relief payments of $250, totaling over $295 million.
Helping States
· TEACHERS - More than 4,300 education positions were reported as funded by the Recovery Act in Q2 2010 in Indiana - which has received more than $1 billion in State Fiscal Stabilization Funds (SFSF).
· MEDICAID - The Recovery Act has already made more than $1.5 billion available to Indiana for Medicaid assistance. The state of Indiana has spent more than $1.1 billion of the available funds.
· 'COPS' PROGRAM: Law enforcement agencies in Indiana received over $26.6 million in funding from the Recovery Act to support 126 police officers' salaries and benefits for three years, including 5 officers at the Kokomo Police Department with $1,146,950.
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This Stainless Steel Pendant measures 41.00 X 31.00 MM. This pendant comes with a 20 INCH 3.5mm Stainless Steel Cable Chain. Item No: 212668 Gender: Mens Material: Steel |
A portion of each purchase is donated | After you make a purchase, you'll be asked which of these three ministries we should direct our donation towards. Learn More >> |


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BeerAdvocate on your phone?! True story. Try the beta now.
Tickets for American Craft Beer Fest are on sale now! (May 30 & 31 in Boston, MA)
Arcadia B-Craft Black IPA - Arcadia Brewing Company
Displayed for educational use only; do not reuse. |
Ratings: 250 | Reviews: 77 | Show All Ratings:
New York
4.3/5 rDev +10.5%
look: 4.5 | smell: 4 | taste: 4.5 | feel: 4.5 | overall: 4
On tap at Uptown Grille Commerce MI
A_ Black with a thick and creamy khaki head. Lacing covers the glass.
S_Hops,dark fruit and floral notes.
T_Hops mellowed out by dark fruits. Figs and cherry. Clove and cinnamon spice on the back end. Great balance of hops and roasted malt.
M_Thick and creamy. Very sticky.
D_Pretty damn good.
Serving type: on-tap
08-11-2010 16:37:25 | More by nickadams2
3.9/5 rDev +0.3%
look: 4 | smell: 3.5 | taste: 4 | feel: 4 | overall: 4
Had on tap at Arcadia.
A- Pours a dark brown lightly blackened color. One finger mocha colored head shows good retention. Good streaky lacing on the sides of the glass.
S- Malts on the nose give way to light roasted front. Piney hops on the backing of this with some light citrus hints here and there. There is a light bitterness in the aroma overall. A muted black IPA overall though in the aroma.
T- Nice roasted malts upfront with a light floral hop flavor. Chocolate notes in the middle of the beer itself with a light soapy taste. Slight bitterness in the ending of the beer with a return of the roasted flavors.
M- Medium light mouthfeel. Carbonation is a little light for a IPA but I think it does the beer justice. Clean flavors with a light overall soapy flavor. Roasted malts left on the palate with some light hops in the aftertaste.
D- This was good flavored black IPA I thought. Arcadia seems to be on the ball and coming up with newer more flavorful beers. Do yourself a favor and try this beer out.
Serving type: on-tap
07-27-2010 03:14:05 | More by alleykatking
Arcadia B-Craft Black IPA from Arcadia Brewing Company
out of 100
based on 250 ratings.


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Kathy Cassidy
First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.
Intel is going after the tablet market for its low-power processors, including an upcoming Atom processor designed for mobile phones, the company said.
Earlier this week, OpenPeak released a reference design for a tablet using one of those upcoming chips, code-named Moorestown. The tablet will have an Atom-based CPU. The OpenTablet 7 tablet comes with a touchscreen is designed for multimedia and video communications, the company said. It is as slim as a photo frame, and weighs 1.15 pounds (0.52 kilograms), the company said.
Tablets are a potential growth area for newer and upcoming low-power, low-cost Atom processors, said Suzy Ramirez, an Intel spokeswoman.
"But it is by no means confined to Atom -- Intel has a range of products that will enable various tablet computing designs," Ramirez said. She did not specify which chips.
Smartphones with the Moorestown chip have already been shown. At the Consumer Electronics Show in January, Intel's CEO Paul Otellini showed LG Electronics' GW990 smartphone, which uses that chip and is scheduled to ship later this year. Finnish company Aava Mobile also showed a smartphone prototype with the Moorestown chip at the Mobile World Congress this week in Barcelona.
The OpenTablet reference design will ship in the second half of this year, OpenPeak said. Intel has pegged release for the Moorestown chip at around the same time.
Intel has little presence in the mobile space beyond netbooks, most of which carry Atom chips, said Dean McCarron, principal analyst at Mercury Research. Because the growth rate for PC sales continues to slow, Intel has to look at new markets like tablets and smartphones to grow, McCarron said. A year ago, Intel said would spend US$7 billion over two years to revamp manufacturing plants in an effort to make smaller, more power-efficient chips as it tries to enter new markets.
Tablets and smartphones require low-power processors, so Atom is the chip for the company to use to jump into new markets, McCarron said. The Atom processor is based on the x86 architecture used in laptop and desktop chips, and Moorestown is perhaps Intel's first low-power x86 chip that can fit into devices out laptops and netbooks, McCarron said.
"Ultimately that's Intel's goal -- not world domination, but x86 domination," McCarron said. "They want to push x86 down to as many market segments as they can."
However, Intel faces a big challenger in rival Arm, whose processors go into most smartphones and are quickly making their way into tablets. Many tablets shown at CES in January use Arm processors. Companies like Dell and Lenovo have already announced tablets with Arm chips. Apple's iPad tablet contains an Apple A4 chip, which is also rumored to have an Arm processor.
Despite Intel's efforts, Arm is a step ahead in developing lower-power processors that may be ideal for tablets or smartphones, McCarron said. Intel has attempted to reduce Atom's power consumption, but it could take years for Intel to come close to catching up with Arm, McCarron said.
First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.
For work use, Microsoft Word and Excel programs pre-installed on the device are adequate for preparing short documents.
The Fujitsu LifeBook UH574 allowed for great mobility without being obnoxiously heavy or clunky. Its twelve hours of battery life did not disappoint.
The screen was particularly good. It is bright and visible from most angles, however heat is an issue, particularly around the Windows button on the front, and on the back where the battery housing is located.
My first impression after unboxing the Q702 is that it is a nice looking unit. Styling is somewhat minimalist but very effective. The tablet part, once detached, has a nice weight, and no buttons or switches are located in awkward or intrusive positions.
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How To Spend Your Labor Day Weekend
Enjoying the last weekend of summer doesn't have to cost you a fortune. -
Living The High Life For $1,000 Per Month
From Brooklyn to Austin, you'd be amazed at what you can rent for $1,000. -
10 Cities Experiencing Home Price Rebounds
Seventeen metro areas in the much watched S&P/Case-Shiller Home Price Indices saw ...


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Kourtney Ann Schlick and Matthew Lee Hoke have announced their engagement and approaching Nov. 11, 2011, wedding.
The bride-elect is the daughter of Jerry and Barb Schlick of Tiffin. She is a 1996 graduate of Calvert High School and earned an associate's degree in business management from The University of Toledo in 1999. She is a production scheduler at Webster Industries, Tiffin.
Her fiance is the son of Dave and Jane Hoke of Tiffin. He graduated from Old Fort High School in 2002 and is a clamp truck driver at Green Bay Packaging, Fremont.


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Component Receivers
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Big Data may be the poster child for NoSQL databases and date warehouses, but one industry veteran isn't giving up on SQL databases for Big Data just yet.
MySQL database, and one of the founders of the community-developed branch of the MySQL database, MariaDB, his take on Big Data bucks the conventional wisdom that large-scale data must abandon SQL databases.
As most IT watchers know, Big Data is perceived as so large that it's difficult to process using relational databases and software techniques. Of course, the relational model and SQL dominate today's database landscape. But on the other side there are databases built without relations, made for higher scalability. We asked the expert in the database area, Monty Widenius, about the current and future state of SQL, NoSQL and Big Data. As the author of the original version of the open-sourceWould you please tell us a little about the history of NoSQL and Big Data? What are the main reasons that this has become such a topic of interest?
The whole thing with the "new NoSQL movement" started with a blog post from a Twitter employee that said MySQL was not good enough and they needed "something better," like Cassandra.
The main reason Twitter had problems with MySQL back then, was that they were using it incorrectly. The strange thing was that the solution they suggested for solving their problems could be done just as easily in MySQL as in Cassandra.
I can't find the original article, but I did find a follow up a bit later where it was said MySQL would be dropped for Cassandra.
The current state is that now, three years later, Twitter is still using MySQL as their main storage for tweets. Cassandra was, in the end, not able to replace MySQL.
The main reason NoSQL became popular is that, in contrast to SQL, you can start using it without having to design anything. This makes it easier to start with NoSQL, but you pay for this later when you find that you don't have control of your data (if you are not very careful).
So, the main benefits (at least before MariaDB) of most NoSQL solutions are:
- Fast access to data (as long as you can keep everything in memory)
- Fast replication/data spread over many nodes.
- Flexible schema (you can add new columns instantly).
What problems can be solved (or do people think they can solve) with the help of Big Data?
More performance and more flexible schemas are the two biggest drivers of NoSQL.
What do you personally think about the future of Big Data? Your predictions?
I think that most of the people who are looking for NoSQL are doing it mostly because it's still 'hype'. Most companies don't have massive amounts of data, like Facebook and Google, and they will not be able to afford to have experts to tune and constantly develop the database.
SQL is not going away. NoSQL can't replace it. Almost everyone will need relations (i.e., joins) to utilize their data.
Still, there are places where NoSQL makes sense. I think, in the future, you will see more combined SQL and NoSQL usage.
This is why we are extending MariaDB to be able to access NoSQL databases like Cassandra and LevelDB.
Why do people still use NoSQL? What are the main reasons?
Because it's easier to get started with a NoSQL database. You don't have to learn SQL and define your database schema before you start using it. A few are using it because they believe it can scale better than SQL.
Can SQL outperform NoSQL? What are some unique advantages that make SQL better than NoSQL?
As soon as data can't fit into memory, SQL generally outperforms NoSQL.
The same goes for things that NoSQL can't do. Most NoSQL solutions are optimized for single key access. For anything else, you have to write a program and it's very hard to beat a SQL optimizer for complex things, especially things that are automatically generated based on user requests (required for most web sites).
SQL can also beat NoSQL on most single machines. In a cluster, where everything is in memory, NoSQL usually outperforms SQL for key lookups.
What do you think about this Cloudera announcement?
The problem with Hadoop is that there is no known business model around it that ensures that the investors will get back 10X money that they expect. Because of that, I have a hard time understanding how Cloudera can survive in the long run.
It's not enough to have a good product. You also have to be able to make money with it.
Who are the primary proponents of Big Data and NoSQL?
All the NoSQL vendors of course. ;)
If this is all just hype, why are they talking about it?
It's not just hype for everyone. There are many big companies and projects that can benefit from Big Data.
However, my point is that most don't need and should not use NoSQL, because it will become more expensive in the long run when you finally discover that NoSQL can't solve all your business needs.
Finally, how does MariaDB fit into all of this?
One of the goals of MariaDB is to be a bridge between NoSQL and SQL. That's why we have added support first for Cassandra and are now working on adding support for LevelDB.
We also recognize some of the needs that NoSQL is trying to solve, which is why we added dynamic columns (which makes your SQL schemas as flexible as most NoSQL schemas) and much faster replication. We are working in MariaDB 10.0 to make the replication even faster, more fault tolerant and flexible. We are also working closely with Galera to provide a multi-master solution of MariaDB.
All of this is to better adapt to a changing world and satisfy the needs people have - or think they have;)
Please tell us about the new MariaDB foundation! What does this mean for developers worldwide?
The MariaDB foundation was created to ensure that it's not anymore just one person or one company that is driving MariaDB/MySQL development. It's only by having a set of independent companies working together with the common goal of keeping MariaDB as an actively developed open source project that MariaDB and the MySQL ecosystem will truly be free and future proof.
What the MariaDB foundation is doing in practice, is ensuring that the MariaDB project is actively developed as an open source project. The foundation is hiring developers to do all the builds, QA, merges, reviews of patches, etc, that is needed for a project to go forward.
Lead image courtesy of Shutterstock, Widenius photo courtesy of Jelastic.


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MondayFebruary 6, 2012 |
Robinson Players to present powerful, provocative 'Laramie Project'Seeking to spark constructive dialogue on campus and in the community, Bates' Robinson Players present "The Laramie Project." |
ThursdayFebruary 3, 2011 |
Robinson Players offer 11th 'Vagina Monologues'For the 11th year, Bates students are supporting efforts to reduce domestic violence with a production of Eve Ensler's The Vagina Monologues, in performances at 7:30 p.m. Friday through Sunday, Feb. 11-13, in Gannett Theater, Pettigrew Hall, 305 College St. |
ThursdayMay 6, 2010 |
Robinson Players present staged reading of professor's 'Nutcracker' adaptationStudent-run theater group the Robinson Players presents staged readings of a Bates professor's adaptation of the Nutcracker story at 7:30 p.m. Saturday, May 15, and 2 p.m. Sunday, May 16, in the Black Box Theater, Pettigrew Hall, 305 College St. The readings are open to the public at no cost. For more information, please call 207-786-8294. |
ThursdayMarch 5, 2009 |
ElectionperfectionThis week, the student theater organization, The Robinson Players, held their elections for next year's board. Theater is one of my favorite extra curriculars here at Bates, and I seriously look forward to the monthly club meetings– purely because of the dynamite personalities all put into one room and allowed to interact (and usually explode) over logistics and theatrical choice and preference. |
ThursdayFebruary 5, 2004 |
'Vagina Monologues' returns to Bates CollegeCarolyn Myles, a Bates College senior, directs the college's fourth annual production of Eve Ensler's "The Vagina Monologues" at 8 p.m. Wednesday, Feb. 11, in the Olin Arts Center Concert Hall, 75 Russell St. The public is invited and donations will be gratefully accepted, with proceeds going to V-Day, an international organization working to stop violence against women and girls. |
ThursdayNovember 14, 2002 |
Bates performances hit crescendo in NovemberWith student performances of music and drama and a recital by Maine's best-known pianist in store, the days before Thanksgiving have a lot to offer in the arts at Bates College. |
WednesdayOctober 23, 2002 |
Theatrical presentations claim spotlight in November cultural calendarFor journalists covering arts and entertainment, the emphasis in November's public arts and entertainment events at Bates College is on stage. Two productions apiece are planned by the college's theater and dance programs, and three by the student theatrical troupe, making the month rich for performance fans. Another highlight for your story planning is the fact that Frank Glazer, an artist in residence at Bates and a pianist of international stature, has two concerts on tap during November. In addition, the month holds one must-cover in literature at Bates, a reading by Camden's own Pulitzer Prize winning novelist, Richard Russo (Empire Falls). |
WednesdayOctober 23, 2002 |
November cultural calendar puts theater in spotlightThe play's the thing when it comes to November's public arts and entertainment events at Bates College. Two productions are planned by the college's theater program (as well as two by the dance program), and there are two by the student theatrical troupe, the Robinson Players. Other performance highlights for November include two concerts by artist-in-residence Frank Glazer, a pianist of international stature. The month also holds a reading by Camden's own Pulitzer Prize-winning novelist, Richard Russo. |
ThursdayOctober 10, 2002 |
Bates student players present David Ives' 'Red Address'The Robinson Players, the independent student theater group at Bates College, presents six performances of David Ives' play The Red Address from Oct. 25 through Nov. 3 (8 p.m. Fridays and Saturdays,. 2 p.m. Sundays) at The Ronj, the student-run coffeehouse on Frye Street. The performances are open to the public at no charge, although seating is extremely limited; no reservations will be accepted. |
WednesdayMay 8, 2002 |
Bates players, campus radio present Shakespeare's 'Lear'The Bates College student theater group present the Maine radio premiere of Shakespeare's "King Lear" in a broadcast from 7 to 9:30 p.m. Saturday, May 11, on the college radio station, WRBC (91.5 FM). |