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Divine Skin Projects Revenues to Reach $15M in 2012
MIAMI BEACH, Fla., May 16, 2012 /PRNewswire/ — Divine Skin Inc. (OTCBB: DSKX), a leading developer of personal-care products, announced results for its quarter ending March 31, 2012. Net revenue was $1.98 million, compared to $2.25 million in the same quarter of 2011. Gross margin improved significantly, to more than 50 percent or $1.05 million, comparable to last year's quarterly result of $1.10 million. Net loss for the quarter was $428,000, compared to $192,000 for the first quarter of 2011.
Highlights from the first quarter include
- Introduction of API System 9 to physicians
- Two new compounds identified that trigger processes for improved hair growth
- Spectral.F7 study was completed with 15 volunteers showing a significant global improvement in hair counts and density
- A new scalable $1.5 million line of credit
- New distribution by United Natural Foods for the NutraOrigin brand
- Extensive regulatory compliance in preparation for launch in various overseas markets.
- Reformulation of the popular Revita shampoo for superior cosmetic benefits while retaining the well-established therapeutic results.
Divine Skin CEO Daniel Khesin stated, "We are on track to see the kind of explosive growth this year that we have witnessed for last year," he concluded. "In 2012, we are projecting $15 million in revenue. That's more than 50 percent growth over 2011."
"So far this year we have closed new deals for more high-margin products, and we have added several new distribution outlets for all items. Such rapid expansion demands greater marketing and inventory expenditures, but we fully expect these investments to bear fruit in the next few quarters.
Khesin continued, "Our expanding distribution and excellent sell through with existing partners contributes to a robust business with our diverse portfolio of product solutions. Most of the shortfall in first-quarter bookings is mainly due to shipping delays. As our current orders ship, we expect to realize much greater revenue."
About Divine Skin
Divine Skin Inc. leads in the development of biotechnology for topical, nutritional, and pharmaceutical therapies. It markets worldwide through online and specialty retailers, cosmetics wholesalers, salons, and medical offices. The fast-growing company went public in 2009.
DS Laboratories, its flagship brand, offers high-performance topical solutions for a wide range of personal care needs. Bioavailability is enhanced through Nanosome encapsulation (www.dslaboratories.com).
The Sigma Skin brand sells through upscale retailers like Neiman Marcus in the United States and Harvey Nichols in the United Kingdom. The topical products address hair loss and other signs of aging (www.sigmaskin.com).
Polaris Research Laboratories makes high-potency minoxidil-based hair-growth formulas (www.polarisresearchlabs.com).
The Pure Guild offers purity with performance: Botanical compounds proven effective in clinical trials are extracted without industrial solvents or damaging heat and are sold through premium retailers (www.thepureguild.com).
Abner Silva
Investor Relations
?Divine Skin Inc.
SOURCE Divine Skin Inc.


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Size ( Size Charts & Fit Guides ) : Please Select a Size
Featuring a D-ring belt, these men's Urban Pipeline twill cargo shorts make comfort cool. Pair with your favorite Urban Pipeline tee or button-down shirt.
- Details:
- 12-in. inseam (Size 32)
- 7-pocket
- Zipper fly
- Cotton
- Machine wash
- Imported
- Measurements are approximate and may vary by size.

subset: commoncrawl


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Following the September 11, 2001, terrorist attacks on the United States, the Department of Transportation was asked to identify areas within the transportation system that were vulnerable to terrorist attack. FMCSA conducted a field operational test (FOT) to quantify the security costs and benefits of an operational concept that applied technology and improved enforcement procedures to hazardous materials (hazmat) transportation.
Deployment: The FOT demonstrated an approach that enhances the safety and security of hazmat shipments from origin to destination by examining possible vulnerabilities in the hazmat transportation system. More detail on the project design can be found in the FOT Statement of Work and the Deployment Documents below.
Evaluation: An independent evaluation was conducted in parallel with the FOT. The evaluation team determined whether or not the FOT met the objective of ensuring the safety and security of hazmat shipments from origin to destination. The evaluator also conducted a benefit-cost analysis that considered safety, security and efficiency. More detail on the evaluation can be found in the Evaluation Statement of Work and the Evaluation Documents below.
Technology Compendium: The project also included the development of a technology compendium, designed to be a comprehensive listing of the different safety and security technologies that are available. The technology compendium is an ongoing effort that will continue to expand and be updated. The most recent version published can be found in Appendix C of the Final Deployment Report.
Attention Technology Providers: To be included in the technology compendium, complete the vendor survey.
This page will follow the progress of the FOT. Below is a schedule of the planned research. Due to the sensitive nature of the findings of this research, not all information will be made available to the public. Updates and non-sensitive information will be made available to this Web site periodically.
For additional information, please contact Joe DeLorenzo at firstname.lastname@example.com.


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About Me
Patient Reviews (41)
"I can't describe Dr. McCarthy as "cuddly" as far as demeanor. But, I was looking for someone to trust my life to -- not someone very personable. I was never anything but confident. His staff, particularly Janice, and the staff at Northwestern were terrific."
"Dr. McCarthy is an extraordinary surgeon. He is not one to hang around and shoot the breeze with his patients but he was there when I needed him (to explain the process and in the operating room) and he took the time to contact my Cardiologist in Miami to share all the pre- and post-surgery documentation. I am forever grateful to this fine physician."
"I strongly recommend Dr. Patrick McCarthy and his team at Northwestern! My surgery was complicated involving mitral valve replacement, Maze procedure and a septal myectomy.
Dr. McCarthy was highly recommended by my cardiologist. His confident manner put me at ease and he and his team did an excellent job. In fact, I'm sure they saved my life.
The cardiac team surrounding Dr. McCarthy are the best including Dr. Robert Silverburg and the team of nurses. Their care both pre-surgery and afterwards are excellent. My entire experience at Northwestern Memorial Hospital was outstanding!"
"From the moment I met Dr. McCarthy, I was put at ease by how he explained everything and took the time to answer all of my questions. He replaced my aortic valve with a bovine valve and I have never felt this good. I was in the hospital for 6 days and immediately noticed that I could breath better and wasn't getting dizzy anymore. I get compliments all the time about how good my scar looks, and I even went in to get a follow up echocardiogram to check how the valve was working and the tech was shocked that I had no scar tissue and how well inside I was already healed after only 3 months. She had no idea who my surgeon was because I live about 3 hours away from where I had my surgery. She just kept saying, "Wow! Your surgeon did an amazing job. I've been doing this job for 15 years and I've never seen a patient at 3 months look this good inside." I would recommend Dr. McCarthy to everyone! He's the very best. My 3 babies and I are so thankful to him for giving me a 2nd chance."
"Results - Excellent. I would recommend Dr. McCarthy and his team. My recovery has been remarkable per my friends and family."
"We were so happy to be referred to Northwestern Memorial and Dr. McCarthy by our local cardiologist, Dr. Sehgal. He set an appointment to meet with Dr. Silverberg and Dr. McCarthy. Dr. McCarthy asked me about my activity level and explained the surgery would eventually be needed but was elective at this point. I decided to have the surgery done now. A date was set and the surgery went very well with no surprises. Dr. McCarthy visited me later and explained that I was doing well. I had the surgery on Wednesday morning and was released on Sunday afternoon. I started a walking regimen on Monday starting with a mile and increasing to two miles after a few days. I was riding my bike 10 miles or more after four weeks. I highly recommend Dr. McCarthy and Northwestern Memorial Hospital."
"Dr. Patrick McCarthy, MD was highly professional with excellent bedside manner and outstanding assistants and support personnel."
"Doctors have always noticed a heart murmur during routine visits throughout my life but told me not to worry about it until I was older. Then, right after my 54th birthday, I was diagnosed with mitral heart valve regurgitation on the left posterior leaflet. Dr. McCarthy was recommended as the best surgeon to fix a paper thin heart valve, and Northwestern Hospital was recommended as the best place for recovery. I am grateful Dr. Bonno had the wisdom to push my surgery to a sooner date, since my health was rapidly declining. During my surgery, Dr. McCarthy was able to fix a small foramen ovale that was not visible on tests. I consider myself lucky to have had Dr. McCarthy, an experienced and updated surgeon, fix my heart that included unexpected findings. The nursing staffs in ICU and in the cardiac ward at Northwestern Hospital were phenomenal in my postoperative care. I heartily recommended Dr. McCarthy and Northwestern Hospital for anyone with heart problems."
"I am totally satisfied with the surgery performed by Dr. McCarthy and his entire team of highly skilled professionals. His skill and judgment were exceptional and everything happened just as he said. I recommend to any patient who needs a heart valve procedure to consult this team, show up, and let Dr. McCarthy do his job. The aftercare was outstanding at Northwestern Memorial Hospital. "
"I feel Dr. McCarthy performed a miracle. He has to be the very best heart surgeon for this type of procedure. His manner was so professional. I have never had better care anywhere. I healed so quickly. Nothing went wrong. I feel better now than I have ever felt. I have more energy. I thank god every day. If I had to do it again, I would."
"I had this valve replacement surgery after having two previous surgeries in attempt to repair my mitral valve. This one was very successful in every respect. At this time, I am feeling well and am at about 80% of the physical capability that I hope to reach, hopefully in the next year. At the present time, I am walking 30 min daily and do out door work with little shortness of breath. I look forward to continuation of down hill skiing this coming winter (as discussed with Dr. McCarthy at time of surgery). "
"One year after having my aortic valve replaced at Northwestern Memorial Hospital by Doctor Patrick McCarthy I've lost 70 pounds and I am swimming 45 minutes a day. I now have energy to burn."
"My Aortic valve was in the severe state and the mitral valve was on it's way out also. I'm from Rockford, Illinois and the doctors there kept stalling because I had radiation damage to my heart caused by Hodgkins Lymphoma back in 1978. When I consulted with Dr. McCarthy, he was puzzled why the other doctors were dragging their feet. He said that 40% of his valve replacements were people like me. Doctor McCarthy and his team did a great job and are always there 24 hours a day for you after your release from the hospital. I would recommend them and this hospital to anyone. As I found out, not all surgeons have the skill level Dr. McCarthy has. Thanks to Dr. McCarthy and his team for helping me and my family during this ordeal. "
"Dr. McCarthy's confidence and demeanor was exactly perfect for me. I was reassured and totally confident he was going to achieve the very best outcome. Dr. McCarthy did exactly what he said he would. I hope I never need to have my heart tinkered with again. However, if I did, I would want him to do it. "
"I am thankful that Dr. Patrick McCarthy did the surgery. He has excellent bedside manner and the surgery went well. I am happily recovering under the care of a local cardiologist, and now doing cardiac rehab locally. My aorta had expanded to the danger point. We found the right surgeon to do the work."
"My name is Pierre Romeus. I'm here to testify that Dr. Patrick McCarthy saved my life. In the past 6 months I've had problems sleeping, breathing and walking. I was in and out of different hospitals and emergency rooms. A friend suggested me to see the No. 1 Cardiac doctor in Illinois and on November 11, 2011, Dr. McCarthy performed an Aortic Valve Replacement surgery on me. He gave me a new birth of life. Two weeks later I'm feeling better, breathing much better and life is normal again. Thank You so much Dr. McCarthy!"
"Just over one week ago, I had my aortic valve replaced by Patrick McCarthy, MD at Northwestern Memorial Hospital. I can't believe how great I feel. I have so much energy and I feel like my heart is working better than ever. Dr. McCarthy and his team have provided me with extraordinary care throughout this entire process. Prior to my surgery, Dr. McCarthy took the time necessary to provide me with all the details surrounding my procedure and valve selection while answering all our questions and giving me the confidence to quickly schedule my surgery. While I was in the hospital, I was visited many times by Dr. McCarthy and his cardiac team members, who were extremely skilled and very patient focused. They were always ready to answer another question or to take extra time with me. Since returning home, I have received several home health visits and phone calls from Dr. McCarthy's team to keep up with my progress and to fulfill Dr. McCarthy's continued recovery regime. I strongly recommend Dr. McCarthy and his cardiac team at Northwestern!"
"We were so pleased with Patrick McCarthy, MD. He was highly recommended, which is why we traveled 128 miles for this surgery. Recovery is going well. Dr. McCarthy and his staff, along with Northwestern Hospital in Chicago are highly recommended. "
"Dr. Patrick McCarthy was able to do a complex mitral valve repair with a ring. The surgery went very well. When I saw Dr. McCarthy after the surgery, he said the mitral valve was no longer leaking, which made me smile."
"When I agreed to having open heart surgery, I was apprehensive about putting my life in someone else's hands. But, when I met with Dr. McCarthy, his confident and professional mannerism quickly put my fears to rest. He explained the surgical procedure and asked if I had any questions. His calm and easy going style gave me the assurance that I was with the right doctor. Of course it also helped that his reputation was exceptional. Dr. McCarthy successfully completed the surgery in less time time than we were told it might take. During my recovery, Dr. McCarthy stopped by my room to see how I was doing and kidded about our Notre Dame connection. My post surgical recovery went much better than I expected but again as Dr. McCarthy predicted. I was home within a week. After a couple of months, I enrolled in a cardiac rehab program associated with Northwestern Hospital. I completed the program and the program nurses commented about what good shape I was in after the surgery. It is now one year later and I am happy to report that I feel great and have more energy than I had before the surgery. I thank Dr. McCarthy and his wonderful skills for this. I would absolutely recommend Dr. McCarthy to anyone who requires this type of surgery. He is one of the best in the country. I have praised him repeatedly to my friends. I know that he has extended the life of my heart and with that has provided me with a better quality of life. Thank you Dr. McCarthy!"
"Doctor McCarthy sat down with me before the surgery and answered all my questions. His bedside manner was business-like and serious, but friendly. I only saw him once after the surgery. Surgery and recovery are going well."
"I am a 91 year old, very healthy, male. Patrick McCarthy, MD was truly a great inspiration. When others turned me down, he gave me hope. A little over 4 weeks and I am doing very well. A little slow, but to be expected. Dr. McCarthy took all the time I needed to explain the procedure, answer all my questions and what to expect. He did a wonderful job and he and his staff, as well as, Northwestern Hospital, treated me with great care and respect. I would recommend him to anyone who needs this type of surgery."
"I can't say enough about Dr. Patrick McCarthy. So professional, very talented, communicated everything so well. I can't imagine anyone doing a better job. Dr. McCarthy was fantastic."
"I also had an aortic aneurysm fixed along with my valve replacement. Doctor McCarthy was wonderful!! He took his time in explaining things to me in terms that I would understand. My surgery was a success! He is very caring and THE best heart doctor in Chicago."
"Words simply cannot describe Dr. McCarthy, his team and the experience I had at Northwestern Memorial Hospital. My family was kept well informed during my 4-hour surgery, that started early, and finished in a timely manner. Dr McCarthy and everyone around him treated me very well. Although I only met with him a few times, my coincidence going into surgery was immediately bolstered."
"I lived in the Washington, D.C. area for approximately 40 years, when a significant mitral valve problem was detected during an annual physical. I was told by an expert at the Washington Hospital Center in DC (a well regarded cardiac program in DC) that I had a particularly difficult valve problem and that I would need a highly experienced and highly qualified surgeon to be able to do a repair as opposed to a replacement of the valve. Because we had family connections in the Chicago area, we preferred to do the surgery in Chicago. My own research indicated that Northwestern Memorial had one of the best heart surgeons in the country, Patrick McCarthy. However, I wanted to rely on my internist's recommendation because he has treated me for over 20 years and is widely respected in the Washington DC area. He recommended, without knowing my preference, that I see Dr. Robert Bonow then head of Cardiology at Northwestern. Dr. Bonow,as I later learned, is one of the top experts in the country in mitral valve issues. Dr. Bonow, after seeing me recommended, as I hoped he would, Dr. Patrick McCarthy. He believed that Dr. McCarthy could do this complicated repair while other doctors elsewhere might choose valve replacement. It was absolutely the right recommendation.Dr. McCarthy explained the surgery, told me he felt it was highly likely that he could repair it, and told me he could perform the surgery a week later. I said let's do it. My surgery was successfully performed January 28, 2011. I was in intensive care for about 2 days (the care was super), regular care for another 4-5 days, and was released. I began cardiac rehab in mid March, 2011 where I live out of state. I have to admit, it does take a while to regain your strength, but cardiac rehab did the trick. It has now been 15 months since the surgery and I have had no problems, no complications. All my tests since then have been fine, including a stress echo which I just took to see how my heart was doing a year later. I feel fine. I am very grateful to Dr. McCarthy and would gladly recommend him to anyone facing such surgery. I am grateful that all roads seemed to have led to Northwestern and Dr. McCarthy. "
"Very Professional. Doctor McCarthy had good understanding of the proposed procedure before surgery. Surrounded himself with excellent team. Result was quite good with recovery better than expected so far."
"We instantly liked Dr. McCarthy. He was very interested in me and answered all of my wife's questions -- especially about what valve he would use (bovine) and the fact that Northwestern hospital has all heart patients in private rooms which results in infection rates below 1%. When his assistant said that he had an opening, we said yes! My recovery has been excellent. Cardiac rehab began and now I'm walking over an hour each day and I work out with a trainer twice weekly. "
"Dr. McCarthy has great experience - all business - all confidence. His team is GREAT - extremely professional, proactive, caring, sensitive, resourceful."
"Dr. McCarthy was very brief, all business, and did not spend much time with me after surgery. I am better. I'm happy with the results."
"When I learned that I would be having heart surgery I was both scared and excited. Scared because it was major surgery and I had never had any surgery before and excited because I had the opportunity to have my valve repaired and hopefully, have a normal life expectancy. On 3-4-2010, Dr. Patrick McCarthy and his amazing staff repaired my bi-lateral prolapsed mitral valve. Dr. McCarthy specializes in various types of mitral valve surgeries and is considered to be one of the best in his field. Not only is he a talented surgeon, but he has the ability to relate to his patients. When I met with him the first time and he told me he was 95% sure that he would be able to repair my valve instead of replace it, I started to cry from happiness that I might be able to be repaired. At that moment he paused while describing the procedure and looked at me and said "clearly you would like to hear more about me being able to repair your valve"...he understood where I was at in that moment and paid attention to what I needed from him. You see my Wisconsin heart surgeon said that my valve repair was very tricky and that he only knew of two surgeons who would have a strong possibilty of repairing my valve instead of replacing it. and he referred me to Dr. McCarthy. At 41 years of age, a repair was in my best interest as opposed to a valve replacement. So, I traveled to Chicago and was fortunate that Dr. McCarthy took my case on. As I reflect upon Dr. McCarthy and his staff and the entire hospital experience, I am truly thankful from the bottom of my repaired heart!! "
"I briefly met Dr. McCarthy in a pre-scheduling interview. I did not see or meet with him pre-op or post-op. However, I was very happy with the result."
"Dr. McCarthy's whole team at Northwestern Memorial was wonderful. They took very good care of me - listening to what my concerns were, visiting me every day, and making me feel at easy. I am thankful I found such a great doctor."
"Doctor McCarthy is an excellent surgeon and very confident with what he is doing. In my opinion, he is one of the best cardiac surgeons in USA."
"Dr. McCarthy is exceptional doctor in a first class facility at Northwestern Memorial in Chicago. He has patents on certain valve replacement procedures."
"I was extremely pleased with the result and hospitalized for only 6 days. Doctor Patrick McCarthy is in high demand and I chose him for his expertise in surgery. "
"Doctor McCarthy is an excellent surgeon. He is personable and professional. My surgery was a success and I am 100%. I feel great and I am back to a full and active life."
"I only remember seeing Dr. McCarthy once after the surgery, but I was wonderfully cared for by his whole team of doctors and nurses. I was extremely happy with the entire process and with the result. And, I experienced NO pain throughout!"
"My experience can only be described as excellent. Patrick McCarthy, MD and his team explained the surgery fully and the choices I needed to consider. The pre-surgery prep was excellent. The informed consent procedures were spot on. (I know because I studied them years before.) The post-operative care could not be better both in the ICU and afterwards. I was in reasonably good shape prior to the surgery, and I'm sure that helped. Now if I could only lose the 8 lbs I gained during my recovery! But once by ounce, I will lose that eventually!"
"Dr. Patrick McCarthy is the finest surgeon to do an Aortic Stenosis. A kind, compassionte surgeon who performed a miracle task. Giving life back to me. I can now climb dunes and walk beaches. "


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How Much Would You Pay To Party With P. Diddy?
Filed under: Events
Diddy is set to appear throughout the evening with DJ Irie spinning all night. The party will take place at Tower Building in Fair Park, 3809 Grand Ave, Dallas, TX 75210 and runs from 9 p.m until the wee hours of the morning. Super Bowl XLV will take place on Sunday, February 6th and will mark the first Super Bowl in the Dallas-Fort Worth area at the new 1.2 billion dollar Cowboys Stadium. Tickets can be purchased on the Capital A website at www.capitalAent.com. The most expensive seats are for a stage-adjacent private cabana which includes 20 VIP tickets, five champagne and 10 premium bottles, open bar, an event hostess, appetizers, dessert, VIP entrance adjacent to red carpet and VIP valet parking all for $25,000.
Over at the 193-room Aloft Hotel, Bud Light is rebranding the hotel the Bud Light hotel for the weekend and bringing in a variety of acts including The Fray, Lifehouse, Snoop Dogg, Flo Rida, Nelly and Ke$ha. MOVES Magazine is hosting its annual Super Bowl party known as "The Players Suite" on February 2. The party will be hosted by Baltimore Ravens linebacker Ray Lewis and tickets are $200.
On February 3, a "Welcome to Dallas Party" includes local favorite Deion Sanders. Tickets start at $50 and go up to the Sanders VIP Table Package ($13,800), which is located right next to Sanders himself. The VIP table for 12 comes with a personal cocktail server, six bottles of liquor, champagne and unlimited mixers. Sanders is also hosting a party on February 5 where tickets range from $75 up to $16,000 for the Sanders VIP Table. After the Super Bowl head back to Zouk night club where VIBE Magazine presents "The Players Gala." This party will feature performances by Chris Brown and Keri Hillson and tickets are available from $75 to $16,000.
[via DFW.com]


text: Posted By Pegsguy on 24 Mar 2011 09:33 AM I think catch and release has contributed to the conditioning of fish. On the other hand, the "hot lure" will stop working when this happens. At this point the anglers will switch to something else. The fish will eventually 'forget' that lure and learn to avoid something else. It's our job as anglers to stay one step ahead of those pea-brains! Tom


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Find exclusive opportunities and packages offered to Society members on the member benefits site.
Find exclusive opportunities and packages offered to Society members on the member benefits site.
Caught in the act hunting for its next meal: A frogfish uses its rod and lure to excite and attract its prey by repeatedly extending and flicking its lure, creating an irresistible appearance of an easy snack. It's the unique rod and lure that describes all frogfish in the order of Lophiiformes, and according to research, this suborder of antennae-bearing fish comprises 14 genera and more than 46 species worldwide.
Very few creatures on earth are as amazing and diverse as frogfish. The discovery of one on a dive can excite any diver or photographer as everyone wants to get a chance to see it. At first glance, the frogfish remains motionless, appearing as a large-headed globular and scabby creature that could hardly fend for itself. But in reality, frogfish are calculating and veracious predators that have truly mastered their domain. But what makes them so unique isn't just their colouration, size, texture, or the ability to remain motionless for hours at a time. It isn't even the little jets behind their legs that help them swim. What makes them truly unique is that they are a type of anglerfish that come equipped with a fishing rod and lure. If that isn't enough to pique a photographer's interest, then I'm not sure what is. But if I've got your attention, check out the photo gallery and take a quick peek at a few more uncommon facts about these uncommon animals.
Mike Bartick was born and raised in Southern California, not far from the ocean in Huntington Beach. After finding his first nudibranch on an Open Water checkout dive, he was immediately hooked on diving. Bartick, who splits his time between the Indo-Pacific and the Eastern Pacific as a freelance photographer, photojournalist and field guide, shoots with a Nikon D300 and D300s, Sea and Sea housings, and YS-D1 and YS 250 pro strobes. To see more of his work, visit saltwaterphoto.com.


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Detergents and Lipids
The Anatrace® product line provides researchers with a wide variety of detergents and lipids for protein applications. Starting with solutions for extraction, Anapoe® detergents won?t cleave or damage proteins. In aqueous media, our unique Fos-Cholines®, Amphipol A8-35, and BisMalts (Bolaamphiphiles) provide answers to protein solubility and stabilization challenges. For crystallization trials, try our NG Class Detergents or Lipidic Cubic Phase solutions. Anatrace products can help you in every stage of membrane protein research.
Detergent Kits
Choosing the right detergent or combination of detergents for a specific membrane protein is not always easy. We offer a variety of solid- and solution-based detergent kits to simplify the process.
Heavy Atom Detergents
Deuterated detergents | Selenium detergents
We offer an array of deuterated and seleniated detergents to help you solve protein structure. Both fully (perdeuterated) and semi-deuterated detergents are NMR silent. The dense selenium atoms can be used to create reference points for X-ray crystallography.
Ionic Detergents
Ionic detergents are effective at extracting proteins from membranes. They are characterized by their harsh nature and tend to denature single protein units and disrupt protein-protein interactions. Ionic detergents have anionic or cationic hydrophilic head groups.
Lipids and Lipid-likes
Bicelles | Cholesterols | Lipid-like detergents | Lipids | Lysolipids
After extraction, protein stability is essential for subsequent structural biology work. We offer a variety of lipids and lipid-like surfactants to stabilize extracted proteins or for transfer into a membrane-like environment for NMR. FosCholine, DHPC, BisMalt, and Chobimalt are among the most popular.
Molecular Biology Detergents
In addition to specialty surfactants, we also offer a range of common detergents that are well suited for initial protein extraction and a variety of other molecular biology applications.
Non-ionic Detergents
Alkyl Glycosides | Glucosides | HEGAs | Maltosides | MEGAs | Neopentyl Glycol (NG) Class Detergents | Polyoxyethylene Glycols | Thioglucosides | Thiomaltosides
Non-ionic detergents provide a good starting point for your structural biology work. The hydrophilic head groups offer ample strength to extract proteins while still providing the capability to stabilize proteins in solution and promote crystal growth.
Specialty Detergents
Amphipol for Refolding | Crystallography | Extraction - Anapoes | NG Class
Anatrace detergents are well suited for specific application needs. Labs using X-ray crystallization techniques should consider NG Class Detergents for their ability to transfer proteins into the LCP and promote crystal growth. When stabilizing proteins in aqueous solutions, amphipathic surfactants such as Amphipol A8-35 are recommended.
We are pleased to offer a small selection of membrane protein reference books to our researchers.
Zwitterionic Detergents
Amine Oxides | Dimethyl Glycines | Zwittergents
Zwitterionic detergents contain both a positive and negative charge in their hydrophilic head group. In NMR-based structural studies of membrane proteins, start with the clarity of Anatrace detergents and finish with greater resolution.


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aoDo This, Not Thata Now Available!
Note: This article was originally published at Planet PHP
on 19 December 2012.
The long wait is over! Do This, Not That: Object Oriented PHP is now available! If you've ever had to rewrite code that didn't pass code review, this book is for you. If you've ever wondered how to improve your PHP development skills, this book is for you. This book is for everybody who ever [...]


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Around €40 billion is being injected into the European economy by the EU executive in a bid to stimulate green job creation. Another €3.9 billion of the European economic recovery plan has been ring-fenced for green R&D and infrastructure projects.
Adding in investments by national governments brings the total to around €90 billion. However, critics say this is a fraction of the €150 billion invested by China and the funds have yet to trickle down to SMEs.
The European Commission has published an eco-innovation brochure highlighting areas where growth is envisaged, including tourism, recycling, hospitality and buildings. Three quarters of the proposals for eco-innovation projects submitted to the Commission in 2008 came from SMEs.
The document stresses the importance of targeting smaller businesses in developing new green industries, but also notes that between 60% and 70% of industrial pollution is produced by small businesses.
The new consultation document on Europe in 2020 sets out the new Commission's desire for a "smarter, greener social market" economy (EurActiv 25/11/09).
On top of this, the EU's Competitiveness and Innovation Framework Programme (CIP) includes an intelligent energy initiative targeted towards SMEs.
Despite the concerted effort from Brussels to drive green growth, the picture across Europe is mixed, with some national governments backing companies in the renewable energy sector and others focusing on a broader range of green technologies.
Industry leaders in the UK have been ramping up the pressure on the government to set a clear policy and regulatory framework to encourage investment in green industries, fearing Europe is falling further behind the US and China.
The Sunday Times newspaper, which runs an annual 'Rich List' of wealthy businesspeople, has now published a 'Green Rich List'. It shows Britain is home to just 10 of the world's top 100 entrepreneurs in new industries, including clean coal, electric cars and wind energy. The US, by comparison, has 35, while China has 17.
Critics say the UK has sent conflicting signals to industry on key energy issues like the future of nuclear power.
However, there have been some success stories. The wave energy industry in Scotland and Wales has been growing, and this month Scotland's First Minister Alex Salmond launched a new hydro-electric device known as Oyster. The demonstration project is already feeding the national grid with power for homes in the Orkney Islands. The project was developed with support from enterprise and research councils in Scotland, in an effort to provide capital to young green companies.
Funding remains a barrier to green industry in the UK and elsewhere. The opposition Conservative party, which analysts suggest will be in power after next year's general election, is promising to set up a "green investment bank". This is designed to help finance environmentally-friendly technologies and businesses, and reward households for recycling.
The French national recovery plan includes €45 billion in green economic growth. This represents 35% of the planned investment between now and 2020. Projects in the transport, building and energy sectors have been prioritised.
A study by the Boston Consulting group, published in June 2009, estimated the plan would create 600,000 jobs in new green sectors over the next decade.
However, critics note that the study was commissioned by the government and say it is difficult to envisage how SMEs will fit into the plan. French MEP Corinne Lepage has called for the evolution of green industries to foster the development of small businesses in France. She said opportunities should not be the preserve of multinational corporations.
In Germany, old factories that once made mining equipment have been revamped to manufacture parts for wind-power generators, subsidise by public funds. Higher taxes on energy help support the transition to a greener economy.
Greener buildings and fuel-efficient cars are also priorities for the German government as it embarks on one of the more ambitious national efforts to go green.
Other small projects have also helped, such as an SME set up by biologist Peter Krost which produces cosmetics from algae. The company has been supported by the Enterprise Europe Network (EEN) which helps SMEs develop their businesses and find partners.
Krost has also devised a system for certifying products produced through sustainable and organic aquaculture, a move that could spur growth in a new niche market.
The Polish government has supported green energy development through its National Fund for Environmental Protection and Water Management. The fund will provide more than one billion zlotys (€241 million) this year in loans to companies that invest in renewable sources of energy.
The move is part of the government's stimulus package aimed at boosting businesses during the downturn. The first phase of the loan programme took place earlier this year, with the next round starting next month (December).
The programme will help entrepreneurs seeking investments for at least 10 million zlotys (€2.4 million), with the maximum loan to one company reaching 50 million zlotys (€12.05 million). Firms benefiting from the scheme can get a reduction in repayments of up to 50%.
Witold Maziarz, spokesman for the National Fund, says that the programme is meant to support small and medium-sized investment projects. "Bigger projects will not run under this project because we assume that big investors do not have problems with raising capital," says Maziarz.
He added that the National Fund plans to start a loan programme to individuals wishing to build household sources of renewable energy. These loans should be available in mid-2010.
By the year 2020, Poland plans to achieve a 15% "green energy share" in its total production of electricity. In September this year the first biogas power plant was opened in the village of Liszkowo in northern Poland. The plant was built by a company called Agrogaz from Poznań and processes mainly waste from the food industry.
The Kozloduy International Decommissioning Support Fund provides support for Bulgarian companies willing to raise their energy efficiency or to produce renewable energy. The fund was established as a support instrument for the decomissioning of part of a Bulgarian nuclear power plant.
Contributors of the fund include Austria, Belgium, Denmark, France, Greece, Ireland, the Netherlands, Spain, Switzerland and the United Kingdom. More than €170 million has been committed in contributions from the European Union and a portion of this money is in the form of credits to SMEs in Bulgaria. The credit line is operated by the European Bank for Reconstruction and Development.
At the start of 2009, new facilities for saving energy in a medium furniture producer in central Bulgaria were built. The project cost €200,000, and was financed by a loan of €180,000. As a result, the company will save about 2,600 megawatthours in electricity and heat annually. This represents a 400 tonne reduction in annual carbon emissions.
Czech Republic
A spokesperson for the Ministry for Industry and Trade (MIT) in Prague, Tomáš Bartovský, told EurActiv that SMEs' green investments are mostly financed using EU money. In particular, the Operational Programme 'Enterprise and Innovation' (OPPI) and its subprogramme on ECO-ENERGY have been harnessed for this purpose.
The Czech government budget is contributing some eight billion crowns (around €300 million) to the programme from 2008 to 2013, representing 15% of its expenses. According to Bartovský, MIT focuses more on co-financing projects based on EU funds than on creating its own programmes.
In the Czech Republic, SMEs can also benefit from the Green Savings programme, based on funds raised from selling Kyoto permits to Japan and other countries. The Green Savings programme focuses on support for heating installations utilising renewable energy sources but also investment in energy savings in refurbishments and new buildings.
The Romanian government currently has no strategy for investing in green projects for SMEs. The political crisis has even affected the implementation of a government decision which would make possible the sale of emissions certificates, with resulting funds earmarked for investment in large energy plants.
Ionut Purica, an expert in energy and environmental problems at the Romanian Academy, told Green Report: "At one moment even on the website of the Ministry of Economy there was a government decision that mentioned sales of AAUs [Assigned Amount Units], in order for green investments to be made, so this money would be used for several projects to which Romania agreed to in the Accession Treaty."
One of the main objectives of the current innovation policy of the Slovak Republic is to create a national innovation system including regional innovation structures, incubators, innovative centres, consulting centres and other elements. The Slovak government considers this as a way to bring support activities as close to entrepreneurs as possible, particularly to SMEs.
Measures adopted to ease the impact of the financial crisis on companies include several green initiatives, such as the reduction of energy consumption and air pollution, and support for R&D and eco-innovation.
The private sector is also expected to benefit from a technology transfer scheme, which will provide SMEs with the tools to cut energy consumption.
€500,000 is also available for innovation start-ups as part of a plan to support around 300 businesses per year. A further €72 million has been set aside to support the improvement of building insulation.
The president of the Slovak association of small enterprises, Vladimír Sirotka, stressed that the programme is not designed for big firms but for about 400 SMEs. Other schemes include subsidies for solar panels and biomass boilers, as well as measures to simulate R&D in SMEs.


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College Navigation
Honors at Frontier Fiesta 2013
Honors alumni are invited to join the Underground Cookers at Frontier Fiesta on Saturday, March 23, 2013. Frontier Fiesta runs from March 21-23 and includes variety shows, carnival booths, concerts, cookoffs, and contests.
The Underground Cookers is a team of insanely proud Cougar alumni who dedicated their (lengthy) collegiate careers to various Campus Activities organizations. Thus, they hold fond (and fuzzy) memories of countless hours spent in the University Center Underground deprived of sleep and other basic necessities. Again this year, they invite Honors College alumni to join them for fun and merriment all day on Saturday, March 23. Come support the University and enjoy a day with Honors alumni and the Underground Cookers.
Please visit the Underground Cookers website for more information and to reserve your tickets.
Honors Alumni at Frontier Fiesta
Who: Honors alumni & the Underground Cookers
When: March 23, 2013 - all day!
Where: Frontier Fiesta


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Machine Safety Labels
Working around machines and equipment can be a hazardous job. Machines have hot surfaces, numerous moving parts, and can start automatically. Unless safety is made a necessity around them, serious accidents and injuries will occur. Posting machine safety labels on your equipment can create a safer environment for your workers, keeping them alert to the dangers around them.
At SafetySign.com, we understand that these hazards demand machine safety labels that can help keep your employees safe. That's why we make durable labels that can withstand temperatures of up to 302°F, so even on machines with hot surfaces, they labels will stay. Protect your workers from cutting hazards, kickback hazards, conveyors, and moving parts that can crush. Order machine safety labels for your business today.
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Moving Parts Hazard Labels
Tell workers that moving parts can crush or cut causing severe injuries.
Hot Surface Labels
Help prevent burns by warning workers and visitors of hot surfaces in your facility.
Cut Hazard Labels
Warn workers that sharp blades on the machine can cut and cause serious injury.
Automatic Start Warning Labels
Notify workers that equipment will start automatically.
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Alert workers not to use equipment with exposed rotating blades.
Crushing Hazard Labels
Remind workers to stay clear of areas where crush hazards exist.
Machine Guarding Labels
Warn people that guards must be in place before using the machine.
Kickback Hazard Labels
Inform workers of the kickback hazard that exists while operating the machine.
Burst Hazard Labels
Warn workers of compressed gas hazards while working with machines.
Lockout Tagout Labels
Remind workers to lock out equipment for safety reasons before working on it.
Laser Warning Labels
Remind workers to avoid exposure to laser beams and wear eye protection.
Emergency Stop Labels
Make sure workers know where the emergency stop switch is for your machinery.
Safety Instruction Labels
Remind people to consult the operation manual for information.
Machine Maintenance Labels
Notify workers that machines must be maintained on a constant basis.


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Police are investigating a drive-by shooting that injured a male in his early twenties next to Colonial Village Apartments at Forest and Tacoma Avenues, near the Cincinnati Zoo around 2:55 p.m.
Policemen and firefighters responded to the incident and temporarily shut down streets near the shooting.
The victim was sent to University Hospital and is in serious condition. Police are currently gathering information to determine suspects.
If you have any information regarding this shooting, contact the Cincinnati Police Department at 513-352-2040.
FOX19 will continue to update this story as more details become available.
Copyright 2013 WXIX. All rights reserved.
West Ferguson Street Tyler, TX 75702 FCC Public File firstname.lastname@example.com 903-597-5588 EEO Report Closed Captioning


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In my local area I have one chevron station that is minimum 5cents cheaper than the 76 or shell...but obviously not cheaper than costco.
I just filled up today at 3.39 for Premium/Supreme 92 oct. the price for regular(87) was 3.19 Shell across the street was 3.19 (87 oct), 3.42(92 oct) Closest 76 station 3.27(87), 3.47(92) So i guess it depends on where you are...chevron closest to me is always cheaper and it 1 block off the freeway. Last edited by liighettoromeo; 01-19-2013 at 06:14 PM.. |
i think its only for select member only. i sign up many times and doesnt look like its went through...
https://discover.ed4.ne |
My Chase freedom has 5% back on gas this quarter (jan-march) which a lot of SD'ers seem to have based on chase freedom threads & Costco True Earnings business gives 4% (I think personal gives 3%) back on gas year round..
Based on the popularity of Costco coupon threads & Costco related deals, it seems like most Sd'ers have Costco membership & could apply for the Costco amex true earnings card. So 2% seem kind of meager to me for discover. Cascada
Gas prices are almost always set by corporate at big name stations such as Texaco and Chevron. Definitely a YMMV deal since many locally owned non-franchise stations might undercut everyone else in your area to boost sales of snacks and such inside the store (where they make their REAL profits!).
Yup. Card holders need to activate in order to get the 5%. Starbucks and drugstores are on the list for this quarter too. Last edited by SAN_MARINO; 01-20-2013 at 06:49 PM.. Reason: Automerged Doublepost Peace, San Marino
How long do you have to wait to fill up a tank at your Costco? I have seen people wait like 10 min or so. Plus, the quality of Costco gas cannot be compared to Chevron or Shell. I tried it before and it burnt so fast. My car has no/less power when accelerated on the freeway. |
Should note that this is a "bonus bonus" cashback.
Currently the Discover cashback for this period is 5% on restaurants and movies. The quarter before that it was 5% on EVERYTHING online. I have Freedom and Discover, I find that their categories usually don't overlap so it's nice to have 5% cashback in multiple categories. For this deal specifically it's pretty weak since so many other credit cards offer more (Freedom = 5%). Last edited by SuperJew; 01-20-2013 at 07:13 PM.. |
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Discover 2% Cashback Jan 1 - Jan 15 | 2Xtreme21 | Hot Deals | 157 | 01-11-2013 05:01 PM |
Vons/Pavilions So Cal. 4X gas reward points usable at Chevron and Texaco | superstud10 | Hot Deals | 0 | 11-07-2012 02:53 PM |
Earn a $10 gift card after $200 use of your Discover card at Chevron and Texaco (YMMV) | swordheart | Hot Deals | 6 | 10-27-2012 11:57 AM |
Discover: 2% Cashback Bonus when using your card in the Caribbean (ends 12/31/2012) | tmiw | Hot Deals | 7 | 10-02-2012 01:18 AM |
Discover Card Cashback Bonus 2% 3/17/2012 Call to Sign up St. Patrick's Day Promo | Nadesico | Hot Deals | 22 | 03-17-2012 06:40 PM |


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Results 1 to 9 of 9
Dear All,
I have searched forums but haven't found any thread for this particular issue.. If anyone of you know any of similar thread then please let me know the link and i will start following it.
As per in all previous smartphones when i allowed apps to use my location then it would work fine if gps was switched off... Apps would use cellular location which is accurate upto 200-300 mts ,
which i think is perfectly alright as most of apps doesn't need fine locations. Apps like searching for restaurants nearby or posting something on facebook with location... it should be done without using gps. I don't know if i am missing a trick here or it is also one of those things which have gone missed by MS and nokia. Even location tagging on pictures clicked were done with cellular data in my previous phones. Or there should be a alternative of automatically switching on and off of GPS when we start using app with permission to location and it should close of its own when we stop using that particular app.
Amit - 02-24-2013, 06:54 AM #2
On my old HTC One X, I could never got any location on my phone, unless I had GPS/location services on. Did I miss something, or are you sure GPS/location was not on, on your previous devices?
WP8 doesn't have a setting for GPS. Just "Location Services" which includes wireless network location services. Turn one off, you turn them all off.
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Photo Book Shows a New Side of Rock Legends
- 11.01.11
Rolling Thunder Revue tour, fall 1975—Bob Dylan and Allen Ginsberg at the grave of writer Jack Kerouac.
Photo: Ken Regan
Keith Richards with his first daughter, Theodora Dupree Richards, in 1985.
Photo: Ken Regan
Stones Tour Party, 1972—Mick Jagger at Michael Butler's house.
Photo: Ken Regan
John Lennon, Paul McCartney, and Ringo Starr in Central Park, February 1964.
Photo: Ken Regan
Janis Joplin at the Fillmore East, March 1968.
Photo: Ken Regan
Jimi Hendrix at the Fillmore East, March 1968.
Photo: Ken Regan
Rod Stewart playing on the beach in Hollywood, Florida, before a concert by Rod Stewart and the Faces, April 1972.
Photo: Ken Regan
Jim Morrison and The Doors at the Westbury Music Fair, January 1970.
Photo: Ken Regan
Johhny Cash
Photo: Ken Regan
People magazine cover shoot with Madonna, February 1985.
Photo: Ken Regan
Run-D.M.C. in the hood—Hollis, Queens, NY—for People magazine's December double issue, 1986, shortly after the incredible success of Raising Hell.
Photo: Ken Regan
Bruce Springsteen on location for the "Streets of Philadelphia" video, December 1993.
Photo: Ken Regan
Ken Regan tells the story like this. It's 1974, he's on assignment for Time magazine and is photographing Bob Dylan in Chicago. It's the first time he's photographed Dylan (who is notoriously private) and doesn't want to screw it up.
While standing in one of the stage wings he turns his camera on the audience.
"In the second row was this woman, she's probably in her sixties, gray hair, surrounded by all these teenagers," says Regan. "And she was standing up and she was clapping and she was cheering and it was such a good photograph because of the contrast between her and all the kids."
The same woman is in the audience the next night so Regan mentions it to his friend Bill Graham, the famous music promoter, who originally got him in the door with Dylan. Graham immediately tells Regan he can never use the photos. Turns out the older woman is Dylan's mom, and Graham knows Dylan doesn't want those photos published.
Time magazine runs three pages of photos but Regan never lets on about Dylan's mom.
Fast forward to 1975. It's 2 a.m. and Regan gets a call from Bob Dylan and his promoters. They're excitedly putting together a plan for Dylan's upcoming Rolling Thunder tour. Dylan had found out about the photos of his mom and knows he can trust Regan. He wants Regan on the tour and tells him he'll have full and unprecedented access.
Regan ends up following the entire tour and comes back with 13,750 frames, including several of the most intimate and personal photos ever made of Dylan.
"I'm saying to myself this is like a dream, having this access to Bob Dylan which no one has really had before," Regan says. "He kind of came out of his reclusive shell on the whole tour."
The story is just one of many Regan can recount after more than five decades of photographing the world's most famous rock musicians. He's got photos of, and anecdotes about, everyone from the Rolling Stones to Madonna and for the first time has published them all in one place — his aptly titled music anthology, All Access.
The book, which is nearly 300 pages long, is an exhaustive look at one of the world's most important recent cultural movements and provides proof of what happens when you spend years developing relationships with people who are notorious for hiding their personal lives.
The edit features your standard shots of Jimi Hendrix breaking his guitar or Janis Joplin screaming into a microphone. But there are also shots like the one he captured of Dylan and beat poet Allen Ginsberg sitting at Jack Kerouac's grave during the Rolling Thunder tour. Or the photo of Mick Jagger lying on the floor, talking on the phone in 1972, and Keith Richards holding his daughter, Theodora, in 1985 — pictures that reveal a more human side of these superstars.
"I was so appreciative of all the friendships and all the access," Regan says. "These people put a lot of trust in me."
The majority of the book covers the 1960s, '70s and '80s. There are photos from as recently at 2010, but it's clear Regan has moved on photographically. Nowadays, he said most of his work is outside music.
Regan's relationships with the musicians, however, live on. Keith Richards wrote the book's preface, where he claims, "To capture a 'moment' you need something else. You have to know the moment before it happens. To sense it, to feel it…. Maybe like hearing a song before it has been written. Whatever this intuitive sense, is what my longtime friend has."
Following the preface is an introduction written by Mick Jagger. Reading theses texts you get the feeling Regan didn't have to call in any favors for the book, but instead simply made a phone call to friends who he developed after years of building trust and making photographs.
To drive that point home, Regan closes the book with an afterword by James Taylor. There, Taylor writes about Regan photographing him and his family, calling back the episode of Bob Dylan and his mom.
"Aside from being a superb photographer, he is the sort of man you can trust to take pictures of your family and not have to worry that they will show up in the wrong place," Taylor writes. "The photographs he takes are honest because we trust him; we can be ourselves around him. He is one of us."
Jakob Schiller is a writer and photographer at Raw File.
Follow @jakobschiller on Twitter.


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Tue, Mar 5 | 8:00 PM WilliB's [Venue Details][Hide Details]
Boise ID |
Zack has been featured on The After After Party w/ Steven Michael Quezada on the CW Network latenight. He has opened shows for Blues Hall of Famer Jimmy Lloyd Rea, and Grammy nominated The James Douglas Show! Zack is in the process of compiling original material with help from songwriters, Marcus Eaton, Dan Costello, Nathan Jay Moody, Richard Soliz, Marc Anthony Romero (King Montana), Bill Waugh and others.
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JOBY GPS-BHEN Gorillapod SLR-Zoom & Ballhead Combo - JB00134-CEN |
Whether you're using your SLR camera to shoot time-lapse photos, get up close with a Macro lens, capture your daughter's winning goal from the sidelines, or snap images for the local newspaper, Gorillapod SLR-ZOOM is the perfect companion for your next adventure. Throw one in your bag and start shooting like a pro! Flexible joints bend and rotate 360° to form the perfect shape. The Gorillapod uses high-quality, injection-molded plastic for snug joints that stay firm after lots of action. Rubberized ring & foot grips provide extra gripping power to grapple wherever you want to go. The Adapter screw allows you to mount both the standard 1/4-inch cameras and other 3/8-inch Professional tripod heads. * Estimated Delivery Dates are based on anticipated order processing and transit times, and are not guaranteed dates. Shipping or Dimension weight in pounds: 1.1 Shipping Options and Policies |
J.R. See more Customer Testimonials | Send us your Feedback | Feedback Terms


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Neuroimaging Studies of the Treatment of Bipolar Depression With Citalopram
This study is currently recruiting participants.
Verified April 2013 by Massachusetts General Hospital
Massachusetts General Hospital
Information provided by (Responsible Party):
Darin Dougherty, Massachusetts General Hospital
ClinicalTrials.gov Identifier:
First received: July 10, 2012
Last updated: April 22, 2013
Last verified: April 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Regional metabolic changes associated with response to 6 weeks of citalopram treatment, using 18-Fluorodeoxyglucose Positron Emission Tomography imaging, will be characterized (FDG PET). The following hypothesis will be tested: Antidepressant response or remission in depressed BPD patients will be associated with changes in cortical (prefrontal, parietal, premotor) and paralimbic (hippocampus, anterior cingulate, subgenual cingulate, posterior cingulate, and anterior insula) regions, consistent with SRI antidepressant response in unipolar depressed patients.
Condition |
Bipolar Depression |
Study Type: | Observational |
Study Design: | Observational Model: Case Control Time Perspective: Prospective |
Resource links provided by NLM:
Further study details as provided by Massachusetts General Hospital:
Primary Outcome Measures:
- rCMRglu [ Time Frame: pre and post-treatment ] [ Designated as safety issue: No ]
Estimated Enrollment: | 60 |
Study Start Date: | April 2010 |
Estimated Study Completion Date: | December 2013 |
Estimated Primary Completion Date: | December 2013 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
Citalopram |
Placebo |
Ages Eligible for Study: | 18 Years to 64 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Study Population
Patients with Bipolar Depression
Inclusion Criteria:
- Current age 18-64 years; DSM-IV diagnosis of BPD, type-I, or type-II; Enrolled in the Citalopram Study at Tufts Medical Center
Exclusion Criteria:
- Current pregnancy, or inability to utilize contraception, The presence of any metallic implants, History of claustrophobia
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01639482
United States, Massachusetts | |
Massachusetts General Hospital - East | Recruiting |
Charlestown, Massachusetts, United States, 02129 | |
Contact: Andrew K Corse, BA 617-643-5129 firstname.lastname@example.com |
Sponsors and Collaborators
Massachusetts General Hospital
More Information
No publications provided
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 13, 2014
No publications provided
Responsible Party: | Darin Dougherty, Director, Division of Neurotherapeutics, Massachusetts General Hospital |
ClinicalTrials.gov Identifier: | NCT01639482 History of Changes |
Other Study ID Numbers: | 2009P002712 |
Study First Received: | July 10, 2012 |
Last Updated: | April 22, 2013 |
Health Authority: | United States: Institutional Review Board |
Additional relevant MeSH terms:
Bipolar Disorder Depression Depressive Disorder Affective Disorders, Psychotic Mood Disorders Mental Disorders Behavioral Symptoms Citalopram Antidepressive Agents, Second-Generation Antidepressive Agents |
Psychotropic Drugs Central Nervous System Agents Therapeutic Uses Pharmacologic Actions Serotonin Uptake Inhibitors Neurotransmitter Uptake Inhibitors Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Serotonin Agents Physiological Effects of Drugs |
ClinicalTrials.gov processed this record on March 13, 2014


text:
Is This the Future of Formula 1?
A Formula 1 Grand Prix is an exciting event for any city, guaranteeing for at least one weekend a year the focus of the eyes of the world. The rich, the famous, the movers and the shakers will all descend for champagne, the roar of powerful engines and to be part of the circus that surrounds every grand prix of the season.
There are very few things in sport guaranteeing such global publicity, international attention, wealthy visitors and a financial windfall as a great Formula 1 Grand Prix hurtling around your city streets. Think Valencia, Monte Carlo, Singapore, Kuala Lumpur, Shanghai, Melbourne — they've all got the world's premier car race running around their streets and tracks. Even Austin will be holding an F1 GP later this year, but how about London and New York (well New Jersey, could these be the latest new addition to the racing calendar?
It certainly seem like an exciting prospect, high-profile Formula 1 race cars zooming around the sensational historic sights of London or speeding along the streets of New Jersey to a backdrop of the city that never sleeps, New York City itself. After all, what's not to like?
Some of the worlds media was invited to a lavish event last week held at London's RAC Club to hear what racing drivers Jenson Button and Lewis Hamilton talk about the prospect of racing on the streets of London. They were even treated to a virtual race around the track. Most people seem very positive about the prospect of a London street race; even F1 supreme boss Bernie Ecclestone was recently quoted in a newspaper saying "maybe we would front it and put the money up for it". Which would be a first, given that usually the venues pay a whooping huge fee to the commercial arm of the sport, for the privilege of hosting F1. There was even some doubt whether this season's new addition of Austin, Texas would even make it to the calendar as their fee was late.
Holding such a race would mean closing off part of central London for at least three days, with the disruption lasting much longer. Whether or not politicians, businesses and Londoner's be willing to put up with such a commotion is still up for debate; however, they've made it work for other big events, such as The London Marathon, The Royal Wedding, The Lord Mayors Show all of which close off most of central London for a day and more. Many eyes will be looking at how the city copes with putting on the Olympics before any further decisions or grand prix plans are made.
Continued on the next page


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Hurricane Ridge sets winter activity schedule
Published on Tue, Dec 7, 2010
Read More
Hurricane Ridge at a glance
Ski season:
Saturdays, Sundays and holidays, Dec. 11-March 27 (weather permitting)
Park entrance fee:
$15 daily or $30 for annual pass
Visitor center:
Open daily, 9 a.m.-4 p.m.
Road conditions:
Call 565-3131 for updates.
Olympic National Park's Hurricane Ridge winter schedule has been announced for the 2010-2011 season.
"Contributions from communities, organizations and individuals across the North Olympic Peninsula provided the additional funding necessary to hire the eight new staff needed to keep the Hurricane Ridge Road open seven days a week this winter," said Karen Gustin, Olympic National Park superintendent.
To celebrate the new seven-day-a-week schedule, and the community-park collaboration that is making it possible, the public is invited to a Grand Winter Opening celebration at noon on Dec. 17 at the Hurricane Ridge Visitor Center.
Hurricane Ridge winter activities and services include:
Hurricane Ridge Road
Weather permitting, the Hurricane Ridge Road is open daily from 9 a.m. to dusk through the winter season, except for Dec. 25.
All vehicles, including four-wheel drive vehicles, are required to carry tire chains when traveling above the Heart O' the Hills entrance station in winter.
A work crew clears the Hurricane Ridge parking lot for use in 2008.
Photo courtesy of Olympic National Park
"Having a set of chains in every vehicle provides an extra measure of safety when sudden storms arrive or road conditions worsen during the day," Gustin said. "In fact, this practice gives us more flexibility in keeping the road open when conditions are marginal."
Winter storms can close the Hurricane Ridge Road; high winds and blizzard conditions are not uncommon.
"'Hurricane' Ridge is well-named and despite our best efforts to keep the road cleared and open, severe weather can force a road closure or delayed opening," Gustin said. "Our Number 1 priority is safety for our staff and visitors."
Road and weather condition updates are available on the Olympic National Park website (www.nps.gov/olym) or by calling the park's Road and Weather Hotline at 565-3131. People can also follow "HRWinterAccess" on Twitter to receive road condition updates.
The Hurricane Ridge Road also may close temporarily if the parking lot becomes completely full. To make best use of the available parking spaces, park staff urges Hurricane Ridge visitors to carpool or use the new Hurricane Ridge shuttle whenever possible and pay extra attention to making the best use of parking spaces.
Entrance fees are collected at the Heart O' the Hills entrance station whenever the road is open. Olympic's seven-day entrance pass, which allows a private vehicle to enter any of the park's roadways, costs $15. The Olympic National Park Annual Pass, good for one year after the purchase date, costs $30.
Hurricane Ridge shuttle van
All Points Charters and Tours provides twice-daily van service from downtown Port Angeles to Hurricane Ridge Wednesday-Sunday beginning on Friday, Dec. 17.
Shuttle vans depart from the Port Angeles Chamber of Commerce Visitor Center on Railroad Avenue at 9 a.m. and 1 p.m. and pick up passengers at the Vern Burton Center at 9:05 a.m. and 1:05 p.m. before the 45-minute drive to Hurricane Ridge.
Vans depart Hurricane Ridge at about 11 a.m. and 3:30 p.m. Scheduling details remain flexible during the start-up period for this new service.
Advance reservations are strongly recommended and can be made by calling All Points Charters and Tours at 565-1139 or 460-7131. Round trip tickets cost $10 per person; rates for special circumstances are under development and will be made available soon. In addition, park entrance fees ($5 per person for anyone 16 years and older) are required at the park entrance station.
Hurricane Ridge Visitor Center
The Hurricane Ridge Visitor Center will be open beginning on Dec. 17. The information desk will be staffed daily from 10 a.m.-4 p.m., except when rangers are outdoors leading snowshoe walks or assisting visitors.
Snack bar, ski shop
The Hurricane Ridge snack bar and ski shop, with both ski and snowshoe rentals, is open from 10 a.m.-4 p.m. on Fridays, Saturdays and Sundays, Dec. 11-March 27; along with Martin Luther King, Jr. Day (Monday, Jan. 17), Presidents Day (Monday, Feb. 21) and the holiday period from Dec. 26-Jan. 2.
Snowshoe walks
Ranger-led snowshoe walks for individuals and families are offered at 2 p.m. on Fridays, Saturdays, Sundays and Monday holidays Dec. 10-March 27. The walks are 90 minutes long and are less than one mile in length. Space on walks is limited, so people should register at the Hurricane Ridge Visitor Center information desk 30 minutes before the scheduled walk.
A suggested $5 donation from each snowshoe walk participant helps the park provide snowshoe walks and repair and replace snowshoes.
Organized groups such as youth or school groups must make advance reservations for snowshoe walks. Group snowshoe walks are provided Fridays, Saturdays, Sundays and Monday holidays at 10:30 a.m. for groups holding reservations. Space is limited, so group leaders should call Olympic National Park at 565-3136 for reservations and more information.
Downhill ski, snowboard area
Weather permitting, the downhill ski and snowboard area operates 10 a.m.-4 p.m. Saturdays and Sundays, Dec. 11-March 27 (closed Dec. 25).
The ski tows are open Monday, Dec. 27; Friday, Dec. 31; Monday, Jan. 17; and Monday, Feb. 2. More information about the Hurricane Ridge downhill ski and snowboard area is available at www.
Cross-country skiing, snowshoeing
Opportunities for cross-country skiers and snowshoe walkers range from open, level meadows near the visitor center to extreme terrain in the park's wilderness backcountry. Anyone skiing or snowshoeing beyond the immediate Hurricane Ridge area should sign-in at the registration box in the Hurricane Ridge Visitor Center and be prepared for steep terrain and the possibility of avalanches.
Information about ski and snowshoe routes and trails is available at park visitor centers, the Olympic National Park website or in the park's visitor newspaper, The Bugler.
Overnight camping
Overnight wilderness camping is permitted in the Hurricane Ridge area with advance registration. Winter camps must be at least one-half mile from the Hurricane Ridge parking area. Overnight parking is not permitted at Hurricane Ridge; parking and shuttle options are explained at the time of registration. More information is available by calling the park's Wilderness Information Center at 565-3100 or the Olympic National Park Visitor Center at 565-3130.
Webcam and weather station
Hurricane Ridge weather conditions are available on the park's website
. The webcam image is updated every 15 minutes (although severe weather can cause webcam outages); weather station information is provided hourly.
Tubing, sliding
Tubing and sliding are permitted only for children 8 years and younger, at the Small Children's Snowplay Area just west of the Hurricane Ridge Visitor Center.
If conditions become too dangerous for sliding, the Small Children's Snowplay Area will be closed. Visitors should check at a park visitor center for current information.
Olympic National Park Visitor Center
The Olympic National Park Visitor Center, at the base of Hurricane Ridge Road, is open daily throughout the winter from 9 a.m.-4 p.m. The Visitor Center will be closed on Christmas Day, Saturday, Dec. 25.
More information about visiting Hurricane Ridge and other areas of Olympic National Park is available at
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Writer's Sound Off: The First Seed
Last week we introduced our new feature, "Writers Sound Off." Our writers are now back at it again.
Each week, our writers will sound off on one topic of the week with short audio takes. If you are a Spurscast subscriber, you'll also be seeing podcasts with all of our takes together along with your weekly Spurscast.
Our topic this week was can the San Antonio Spurs make a late playoff run without the first seed. Listen below and then find out how to join in on the fun.
Michael De Leon, Founder -
Jordan Rivas, Writer -
Paul Garcia, Staff Writer -
Jason Rogers, Staff Writer -
Arianne Villanueva, Spanish writer
Jake Faunce, Staff Writer -
So those are our takes for the week. Feel free to use our comments section to give your take on if you agree/disagree or want to pick who's take was the best.


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Gutsy Munoz Sculpture at the Clark
Juan Muñoz was a storyteller, but the story is yours to tell, not his. In Conversation Piece five bronze below life-size figures whose legs are bagged teeter towards one another, but they aren't speaking. It's your job as the viewer to interact with them, walk around them, and decide for yourself what you make of their enigmatic placement and size. Strange and alluring, their eyes are stitched closed, but they reach out to one another yearning for something. Each statue is anchored to its spot, frozen in time, on the terrace of Stone Hill Center, the woodsy space and exhibition gallery of The Sterling and Francine Clark Art Institute in Williamstown, Mass.


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Seas in art
From Conservapedia
Seas in art
- The sea and its pictorial representation have been one of the most developed art genres since many centuries ago. From the classical, serene seascapes by Fitz Hugh Lane to the contemporary visions of Richard Diebenkorn, the audacious Japanese Painting or -of course- the incomparable William Turner. (by G. Fernández - theartwolf.com) [1]
Icebound Whaling Ship William Bradford |
Icebound Ship William Bradford |
Sealers Crushed by Icebergs William Bradford |
Floating Iceberg Frederic Edwin Church |
Aurora Borealis Frederic Edwin Church |
Dutch whalers near Spitsbergen Abraham Storck |
Storm at Sea - detail Pieter Bruegel the Elder |
The Raft of the Medusa Théodore Géricault |
The Ninth Wave Ivan Aivazovsky |
Malta Valetto Harbour Ivan Aivazovsky |
Syria by the Sea Frederic Edwin Church |
La Corniche Claude Monet |
Women Bathing Paul Gauguin |
Marina Joaquin Clausell |
The Iles d'Or Henri-Edmond Cross |
Man at the Helm Theo Van Rysselberghe |
The South Ledges, Appledore by Childe Hassam
Clearing Up, Coast of Sicily by Andreas Achenbach.
Sea Wave Kanagawa Katsushika Hokusai |
Tahitian Women on the Beach Paul Gauguin |
Horsemen on the Beach Paul Gauguin |
Fatata te miti (Near the Sea) Paul Gauguin |
Bark Auriga in Antarctic Waters (detail) George Chambers |
The Thames in Ice James Whistler |
The Seine at Argenteuil Alfred Sisley |
See also
Boudin, Port de Camaret, 1872.


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Critical Essays
Critical Evaluation
Three of D. H. Lawrence's most important themes are prominent in "The Rocking-Horse Winner": the corroding effects of acquisitive behavior on English society, the requirement for a truly loving relationship to achieve happiness and fulfillment, and the existence of forces in the natural world that humans might access if they were not limited by social and cultural conventions. These themes structure and inform the narrative, intertwining so that the presentation and development of each theme is connected to the others. Taken together, they offer a view of the philosophical positions that Lawrence worked toward in his most memorable writing.
Lawrence's father was a coal miner. He made an adequate living, but his wife had aspirations to a more comfortable and refined social setting. Lawrence himself was more concerned with aesthetic and romantic matters than with monetary ones, but as he began to write about British society he became increasingly displeased with what he felt was an economic system that placed an emphasis on things that he felt were not crucial for human well-being. As he wrote in Apocalypse (1931), "What we want is to destroy our false, inorganic connections, especially those related to money," a sentiment similar to many others that he expressed throughout his life. The advent of World War I forced Lawrence and his wife, who was of German descent, to move away from the Cornwall coast. Lawrence was living at the time primarily on borrowed funds and, in the words of his wife, was "a walking phenomenon of suspended fury." In addition, as he became a professional author, dependent on the income his writing produced, he was increasingly involved in negotiations regarding remuneration for his work.
Lawrence wrote "The Rocking-Horse Winner" for a collection of ghost stories being compiled by Lady Cynthia Asquith (who was partially the basis for Hester's character). He was paid fifteen pounds for the story's English publication rights and fifty pounds for the American rights. To put this payment in perspective, Virginia Woolf in her 1929 "A Room of One's Own" recommended a sum of five hundred pounds as minimal to secure an artist's independence. The sums that Paul's sure winners return, then, are far beyond what would be required to sustain an upper-middle-class family, and enough to place a family within the reaches of "real money," if not fabulous wealth. The family's final winnings of more than eighty thousand pounds would be equivalent to several million pounds in the twenty-first century.
Lawrence chose these impressive sums, far beyond what most of his readers could even contemplate, to demonstrate the futility of seeking ever-larger amounts of money in a futile quest for the elusive satisfaction of being rich. The corrosive effects...
(The entire section is 1156 words.)
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Subscribe now to read the rest of The Rocking-Horse Winner Critical Essays. Plus get complete access to 30,000+ study guides!


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Both The Ghost Writer and Shutter Island follow a grand tradition of cribbing from a certain portly Englishman. Cue A Lesser Bernard Herrmann
From zombie games to zombie horror movies - how to make it past the flesh eating hordes.
Liam Neeson is a straight up badass. Here are 11 reasons why we think Liam Neeson is one of the most badass actors working today.
Handsome comedians are weird. Ugly comedians are better. Fat comedians are the best of all.
Some people should never be allowed within arms length of a child. Keep this guys far from your offspring.
Zombies don't care if you're a plumber or a rock star. They just want tasty human flesh....
The UGO Hell Guide to everything devils, demons and hell.
Clock in with In Time with a look at some of the best action scenes from The Rush library.


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Samsung, Apple top smart device sales
Samsung and Apple led the field of makers of "smart connected devices" in the third quarter as sales hit new records.
Will ultrabooks go the way of netbooks?
Adam Turner Can ultra-skinny notebooks fight off the tablet hordes?
Hands on: Acer Aspire S3 ultrabook
Adam Turner It's not the sexiest ultrabook around, but the Aspire S3 has plenty to offer.


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The Island Crust Café was standing-room only as the kids emptied the pizza trays.
As Shabbat came to a close on Jan. 19, the parking lot at the Stroum Jewish Community Center on Mercer Island was lined with limousines. Fifteen stretch limos, and their chauffeurs, carried 135 teens from most of the area's Jewish youth groups — NCSY, NFTY, BBYO, USY at Herzl-Ner Tamid — split up into groups for a scavenger hunt around the Seattle area that took them to such places as the original Bikur Cholim synagogue, now known as the Langston Hughes Performing Arts Center, Safeco Field, and the Pike Place Market. The kids were dropped off at Island Crust Café to finish the evening with pizza and snacks. Funding for the multi-group event came in part from a grant by the Jewish Federation of Greater Seattle.
After an entertaining video with the scavenger hunt's rules and regulations, the kids rush out to find their limos.
Members of Team 3 get themselves situated in the limo as they get ready to head out for the evening.
Team 15 — the winners of the hunt — at one of their stops. Photo by Ari Hoffman.
The new Professional Directory to Jewish Washington is now accepting listings for your business. Visit www.professionalwashington.com today to get started!


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Holiday Overload? 5 Ways to Undo the Damage
You're bloated, excessively tired and have had enough fudge and cookies to stock the Willy Wonka Chocolate Factory. It sounds like you're thoroughly enjoying the holiday season – and that's what it's all about it! So instead of feeling guilty for the gluttony, get to work undoing the damage. Read more →


text: Hey you, I'm a 17 year old girl from the Netherlands I'm a american horror story fangirl (EVAN PETERS!!) I love books, obe of my favorite writers is Edgar Allen Poe I love everything thats horror and gore, skeletons blood you name it, I love it. Creepy??? well maybe but I know you love it too |


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Designed to emulate the size, shape, and profile of a natural leech, the Gulp! Alive! Floating Jumbo Leech is as close as you'll get to the look and feel of live bait in an artificial lure. Its unique fluttering motion imitates the action of a wounded leech, provoking strikes from walleye, pike, and bass. Its natural design, paired with the Gulp! Alive! scent formula, outperforms live bait. Gulp! Alive! water-based formula is molded into the body to creates a broad scent trail in the water. Breaks down in water, but won't dissolve off the hook! This non-perishable bait lasts just as long as any soft plastic lure on the market. Does not require refrigeration. Replaces live bait for better durability and longer lasting results. Works nicely as a jig trailer for flipping bass or can be substituted for a worm in a variety of other techniques. Comes in soaking a resealable jar for safe, secure storage. 5" long. 13.4-oz. jar.The next generation in Gulp! technology, Gulp! Alive! Lures absorb 20% more scent-and-flavor formula than original Gulp! lures and disperse over 400 times more scent than other plastic baits. These realistic little lures come soaking in a jar of Gulp! Alive! juice for maximum attraction power. The resealable jar enables you to reload your baits with scent and flavor every time you put them away. Designed with improved swimming action and authentic detail, Gulp! Alive! lures offer a lifelike profile when released in the water. 100% natural and biodegradable. |
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- Irresistible to Fish
- Looks Realistic
Best Uses
- Fresh Water
- Jigging
Comments about Berkley Gulp! Alive! Floating Jumbo Leech:
These things work great. When all else fails, these will find the bass!
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Release Date: 02/26/2013 | Tracklist
Texas teaDigging: Love American - Hollow Crosses
Digging: Love American - Hollow Crosses
Album Rating: 3.5I haven't reviewed a hip hop album in a little while, so I didn't want to miss the chance. Too many hip hop albums get delayed.Digging: Jamie Isaac - I Will Be Cold Soon
Digging: Jamie Isaac - I Will Be Cold Soon
Album Rating: 3.5Also, looks like something went wrong with the album artwork when I made the album page. I'm pretty sure it was a .jpg, I'll fix it later.
I'll fix it now for you.
Album Rating: 3.5Thanks Jake, much obliged.
Album Rating: 3.5He's a rapper on Tech N9ne's label, and the tracks are about your typical stuff. Bitches and snitches, that sort of thing.
Album Rating: 4.0I really dig this album. Only started listening to Kutt since "Red-headed Stepchild." I found this album to be a new favorite of mine.
Album Rating: 3.5noiceDigging: Mick Jenkins - Trees And Truths
Digging: Mick Jenkins - Trees And Truths
Bands: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z