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Looking for an over-the-top luxury holiday getaway without using your passport? The iconic, Beaux-Arts style Hilton Chicago is now taking $10,000-a-night reservations for the largest, most elaborate, and most expensive hotel suite in the Midwest — The Conrad Hilton Suite — now that its astounding $1.8 million beautification is complete.
The next time you check into The Hilton San Diego Airport, you will be in for a pleasant surprise. The 211-room property has officially completed its multi-million dollar renovation project, including guestrooms. Guestrooms now have entirely new... Read More
The Conrad Chicago, one of Hilton Worldwide Hotels' most iconic properties, announces the newly renovated Conrad Hilton Suite. This winter season, Hilton Worldwide is featuring exclusive Chillcation packages throughout the winter season.... Read More
The Hilton Cartagena has just announced the completion of a multimillion dollar renovation that included both 288 main tower guest rooms and the spacious pool complex. Led by two local designers, Juan Manual Garcia and German Lopez Barrera, the new guestrooms have a more spacious feel that brings the sea inside. Guestrooms feature Hiltons Serenity Collection of amenities including plush bedding, high-definition flat screen television, alarm clock with MP3 player connection, wireless Internet access and more. The pool complex renovations included a brand new non-slip marble floor and landscaping, offering guests an elegant outdoor experience.... Read More
SER Steakhouse + Spirits, located in the Hilton Anatole in Dallas, Texas is now open. The "new breed" of Dallas steakhouse offers chef-driven cuisine featuring the finest steaks and chops, market-fresh seafood and other distinctive dishes, which can be paired with an extensive list of handcrafted cocktails and wines. With unparalleled views of the Dallas skyline and a warm ambience of cognac and whiskey leathers, locally sourced end-grain mesquite walls and community tables, rich mesquite floors and solid walnut tabletops, the restaurant is both hip and urban. As a special touch, the restaurant offers guests the opportunity to dine at a chef's table and wine display adjacent to the exhibition kitchen.... Read More
Hilton has just announced its first all-inclusive property in Mexico, with the opening of the new Hilton Puerto Vallarta Resort. The resort is smaller than similar properties in the area, making it less overwhelming for guests. The Hilton Puerto Vallarta Resort offers a variety of international dining choices, as well as a fitness center, spa and several pools. Today Mexico adds yet another all-inclusive resort to its hotel inventory with the opening of the Hilton Puerto Vallarta Resort. Its Hiltons first one-price-pays-for-all property in Mexico. Right in the heart of PVs Hotel Zone near the Bay of Banderas, this Hilton is pretty modest in size with just 259 rooms and suites, which makes it less overwhelming than other resorts of its kind in the region. Guests won't go... Read More
The first guests of the Hilton Carlsbad Oceanfront Resort & Spa entered the new hotel last week on the evening of June 21, 2012. Located in San Diego County, across from Ponto Beach, the 215-guestroom deluxe resort features the culinary delights of acclaimed Chef Pascal Vignau at Chandlers Restaurant & Lounge and the 5,600-square-foot Ocean Crest Spa facility. We are truly thrilled to have opened this beautiful resort, and we are grateful to our team, to our Carlsbad neighbors and to the many guests who have already booked stays, weddings and events with us, said Bill Canepa, managing partner, Wave Crest Oceanfront LLC and president, Wave Crest Hotels and Resorts. I cant think of a more beautiful resort setting in all... Read More
Veteran CEO and Marketing Executive John Vanderslice is Hilton Worldwides Global Head of Luxury and Lifestyle Brands. In this role he has expanded the Waldorf Astoria and Conrad brands, and has expanded those brands within the past few year so include many in Central and Western China, also Macau, Koh Samui, The Maldives, London, Berlin and Panama.... Read More
For a traveler unfamiliar with Atlanta geography, the recently renovated Hilton Atlanta is like a homing beacon its driveway an immediate turn straight off the freeway exit, and its shining 28-story bulk impossible to miss. As homebase for Delta, CNN and Coca-Cola, Atlanta is one of the business travel centers of the south.... Read More
Hilton San Diego Bayfront has been recognized by the American Automobile Association as a Four Diamond hotel, a distinction reserved for properties with "a high degree of hospitality, service and attention to detail" as characterized by the association. Collectively, Four Diamond establishments represent just 3.6 percent of the 59,000 annually rated properties and restaurants.... Read More
One of the Hilton group's most surprising properties, the Bentley is a sexy little Latin package with big flavor...and big rooms. It sits on an iconic intersection that's seen many rises and downturns over the past half-century; along with Prime 112 across the street and DeVito's a couple doors down, it's pretty much created its own little mini-neighborhood.... Read More
Today's travel is brutal, which is why every traveler wants to wind down after enduring that ordeal, at a picture-perfect destination hotel. One with, say, two gorgeous beaches on the Caribbean Sea, lovely cascading pools, excellent restaurants, terrific gym, three tennis courts, an Executive Lounge, beautiful guest rooms - all with blue-ocean views - and a lot more. In other words, you want to arrive at the Hilton Barbados.... Read More
Luxury Specials: This spring, travelers can rejuvenate with a soothing escape to the Island of Enchantment with the Spring Escapes Package being offered by five of Hilton Worldwides properties in Puerto Rico...... Read More


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Elizabethan Classics faucets offer a vintage design with all ceramic disc cartridges for modern functionality and dependability. So go ahead and indulge yourself in the best of both worlds - beauty and luxury, with the convenience of modern day innovation. All faucets are available in four finishes to perfectly compliment any decor.
Wall Mount Exposed Shower Faucet with Hand Shower 1/2" IPS Inlets 3-3/8" Centers 17-1/2" Shower Arm Reach 54" Overall Height Includes handshower, cradle and optional wall bracket Requires showerhead
TypeWall MountHandle StylePorcelain LeverHandles IncludedYesHandshower IncludedYesHeight54Weight10.21MaterialMetalHandles2Shower arm reach17-1/2


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Astro photo processing instructions here...
USAF Retired
GM-8 GII (soon w/OPWB) ; Orion Sirius w/EQMOD
Orion 80ED; AT72ED; AT6RC
Atik 314L+; Atik 420C
Moonlite Focusers, Moonlite stepper motor
Astrodon 5nm Ha, LRGB; Baader OIII, SII
Starlight Xpress 7x1.25" FW
Sequence Generator Pro, PinPoint, PixInsight, PS CS 5
Telescope: Takahashi FSQ-106EDXIII Mount: AP Mach1, CGEM DX Cameras: FLI ML16803, Canon T3i (unmodded), Canon T2i (self-modded Astrodon), PGR Flea3 Mono CCD Misc: CFW 4-5, ATIK EFW2, RoboFocus, MicroTouch Wireless Autofocuser, Astronomik Type IIc LRGB,IR742, Astrodon OIII3nm, Ha5nm & LRGB http://hythamsafieh.smugmug.com http://www.astrobin.com/users/Hytham
Modded C9.25, Vixen SP retrofitted with DS motors and Autostar My pics
Stars light the world without, to give us purpose
They light us within to give us reason
We live in a well-lit abyss.
Quote:Rogelio Bernal Andreo aka my freaking inspiration.
Celestron C-8 SCT
Schaefer GEM
Gary Honis modified Canon 450D (Baeder Mod)
MonoMods monochrome Canon 450D (Debayered, Baader filter, LPF1 removed)
ONAG On-Axis Guider
Starlight Xpress Lodestar Autoguider
Robofocus RF3
Canon EF 200mm f/2.8L II USM
Olympus Zuiko 50mm f/1.8
Quote:There are a number of those on the PI site
Kevin AD5VG
BackyardEOS ~ Purpose-built astrophotography software!http://www.backyardeos.com/CANON, NIKON, QSI, SBIG, ATIK, SX, ASI, QHY, SSAGAT8RC, AT6RC, AT65EDQ, EON 120mm, Lunt 60THa B1200ASTRODON LRGB Ha NII SII OIII (3nm), IDAS, CLS, SkyGlow10Micron GM2000HPS (ordered), NEQ6, HEQ5, CG5-GTOne clear night a year
Quote:I just bought Part 1 and Part 2 from IP4AP .I really need all the help I can get for PixInsight... powerfull... but steep learning curve.Guylain
Quote:Hiwhat can I do to help make the basics better to understandAlways open to suggestionsHarry
Quote:what can I do to help make the basics better to understand
Quote:Add to that a basic workflow as follows and you are on your wayStack (calibrate + integrate) -> crop boundaries Gradient removal and color correction (DBE, Color calibration, SCNR)Noise removal via Atrous Wavelets---Stretch - Histogram transfer (levels)HDR wavelets to increase dynamic range LHE Local contrast enhancementACDNR, Nose reductionSaturation Boost via curvesThe dashed line separates the first three steps you do on linear data. The latter are done on stretched and therefore non-linear data. Harry has a tutorial for each of these major steps. I do these steps (in addition to others) on every single image I process.
Celestron 925 EdgeHD Hyperstar
MicroTouch Focuser
Canon T1i modified by Brent Oliver
Bogota, Colombia
Quote:Some very basic questions/scenarios if someone can help: Note: CR2 files I am working with at the moment are already in-camera noise reduced. •Harry's first video 'Alignment and Stacking' starts off with 'Star Alignment' process using FIT files but doesn't mention how to convert CR2s into FIT. What manual (not batch) process is used to convert CR2s to FIT in PixInsight, especially the ones that are already noise reduced/calibrated? •What's the easiest/quickest way to get to 'Star Alignment' stage with in-camera noise reduced CR2s? How optimal it is to directly use noise reduced CR2s [not FITs] in 'Star Alignment' process in PixInsight? •If I try ImagesPlus converted CR2->FITs in 'Star Alignment', I get error "multiple images cannot be used as registration references", although I am using one reference image. •'Star Alignment' process RUNs if I directly feed noise reduced CR2s, but running 'Image Integration' afterwards [on FITs produced in 'Star Alignment'] produces somewhat garbled 'rejection high/low' and 'integration' outputs. In short I am very familiar with this CR2 conversion/alignment/combine in ImagesPlus but am kind of stuck getting things going in PixInsight (i.e., CR2 conversion, star alignment, image integration); I have good data by the way since same files work fine in ImagesPlus and produce excellent results. Your help will be greatly appreciated. Thx
Quote:Here you will find the recommended workflow for DSLR images with PixInsight.Best regardsAlfredo
Quote:Just to clarify, that thread is a step-by-step process to stack CR2 files. The entire process has been replaced by the Batch PreProcessing script, which can accept CR2 files and output fit files. It is a good thread to understand more how the script works or if you want to start doing it manually before using the script.
Quote:Yes, but as the dialog box warns, the Batch process doesn't produce as good results as doing the workflow. I did it both ways and can tell you there's a HUGE difference in the final stacked image. The workflow is not as hard as appears to be.Having said that, results for every one might be different. Best regardsAlfredo
Quote:What kind of difference did you find between the two methods to determine the manual process is better? Also, since the note says that best results are obtained by fine tuning, did you make any (consistent) adjustments different to the thread instructions to get better results?Thanks in advance,Jeff
Quote:...I used Nebulosity to calibrate my images with Darks, Flats, Bias and Flat Darks because I saved my initial files as compressed FITS. After calibration I have Neb output 32 bit Fits that can be easily read by PI. This is the most efficient path for me time, CPU and disk-space wise.
Quote:You could also use the output of calibrated files from ImagesPlus and move on to the stacking routine (Image integration) in PI.
Quote:The script will calibrate and register your images perfectley and you do not need to do the manual stuff, It is only the intergration you might need to run seperatley , only a check of the rejection maps will tell you this . i.e you can use the newley created registered and calibrated frames and run intergration on its own
- Sean
Astrophoto: Intes Micro ALTER-M606 (6" f/6 MCT), Astrotech AT6RC (6" f/9 RC), 2x Tair-3 lenses (300mm f/4.5)
Visual: Celestron 8 SCT ('77 Orange Tube, 8" f/10), Selsi #247 Refractor (aka Towa #339, 80mm f/15), Tasco 11TE-5 Newtonian (4.5" f/7.9), Galileoscope (50mm f/10)
Mounts: Celestron CI-700, iOptron ZEQ25GT, Celestron CG5-ASGT, plus a couple old EQ2s
My Astrophotography Site: http://ap.x-wing.ca/
Mach1GTO / G11/G2 (stock) / AT6RC / AT10RC / TMB92SS / Astrodon 50D / STT-8300M / FW8G-STT / PixInsight / etc, etc. Astrobin - Flickr


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A white pelican in the Sepulveda Basin Wildlife Reserve lake that was injured in October has recovered, thanks to the combined efforts of local residents and animal services agencies, and was set free and back into the wild Saturday.
The lucky bird was released on Saturday, December 1 around 11 a.m. at the Sepulveda Basin Wildlife Lake by International Bird Rescue, according to Valley Audubon member Muriel Kotin. It was released at the same time as a second pelican that had been found in Long Beach with a broken bill.
The distressed pelican was spotted by a San Fernando Valley Audubon member in October with a plastic bottle caught on one of its feet. They reported the incident, and the bird was rescued and rehabilitated with the help of Muriel Kotin of the Audubon Society, photographer and nature enthusiast Jim Hanlon, the West San Fernando Valley Animal Services Specialized Mobile Animal Rescue Team including Annette Ramirez and Officer Armando Navarrete, the California Wildlife Center, International Bird Rescue, East Valley Animal Shelter and the California Wildlife Center.
Click on the slideshow to see photos of the injured pelican being captured, restored to health and released.


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From Wikiquote
This was a great book. I thought it was hilarious. I like the idea of Nately's whore popping up everywhere trying to kill Yossarian. even at the very end before he runs away :)
Me too.22.214.171.124 05:09, 13 July 2008 (UTC)
link to the book[edit]
mmmmm.... is the contents of the link to the book legal!!..... at the end of the page
I guess not. It's been pulled.
Length of article[edit]
This is getting a bit long. Are we near copyvio territory?--Ole.Holm 12:28, 24 February 2010 (UTC)
- I tagged it for review. At least it could use some quality cleanup. ~ Ningauble 14:01, 24 February 2010 (UTC)


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Announcing the 2013 Data Virtualization Innovative Solutions Award Winner
Posted by: Bob Reary
Best Practices, Business Value, Case Studies, Data Federation, Data Integration, Data Virtualization
Making insightful usage of the growing plethora of internal data is difficult enough. But what if the business thrives and grows by developing data external to the firm, using it to sell insights to customers and to shape new products as well? Associated challenges are even greater since each...


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Home > T-Shirts & Apparel > T-Shirts > Gaming >
Crit Happens
The Way of the Dice
Chaotic Evil
Chocolate Gaming Dice Set
Critical Hit D20 3D Window Decal
Death will come soon
In the Navy, you get a very small bed.
The L stands for Leonard.
Yet another senseless casualty
Striking a Wil Wheaton pose?
The Bag of Holding
Critical Hit LED D20 Die
Shirt of Smiting
Gift Certificates


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Houston Zoo says goodbye to female African lion
November 16, 2012 | Updated: November 17, 2012 10:32am
The Houston Zoo said goodbye to Celesto, a female African lion and the last of a lion legacy Friday morning.To continue reading this story, you will need to be a digital subscriber to HoustonChronicle.com.
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While mobile commerce is still in its infancy in the US, and even more so in the UK, there are signs that users are coming round to the idea, with 71% saying they feel it is safe to make a purchase on their mobiles.
An eMarketer round up of recent mobile commerce stats also reveals some interesting information about the kinds of products people want to buy from their phones.
Read more...
by Graham Charlton 10 June 2009 12:03pm 0 comments


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AZ Adoption Records Finder
Arizona Confidential Intermediary
Imagine finally meeting a biological family member and getting answers to questions that have lingered for years…
I am a certified Confidential Intermediary certified by the Arizona Supreme Court . I am able to open sealed court records, agency records, and even the sealed birth certificate.
My mission is to help reunite the individuals separated through adoption with their biological family.
I was adopted at the age of three and understand the complex feelings associated with being adopted. I have personally been through the adoption reunion experience myself. In 1991, I successfully located my birth parents. Because of the reunion, I was able to learn about my ancestry, family health history, and early childhood development.
I also learned the fate of my siblings, who were separated from me during the adoption process. In 2000, I took it upon myself to locate my sister and two brothers. I located my sister first who informed me that one of my brothers had died. I wish I had been able to meet my brother, but I had waited too long to search for him.
I am able to help you reunite with your biological family if the adoption was finalized in Arizona. If you are an adoptee, adoptive parent of an adoptee, birth parent or a biological sibling of an adoptee, I can assist you if you are at least 18 years of age. When working as a Confidential Intermediary, I am not permitted make contact with individuals under the age of 21.
Please feel free to email or call me, and I can tell you more about my services.
Fees are involved, but the Supreme Court sets guidelines for those fees. My rates are reasonable.
Whatever method you may choose, I wish you the best of luck reuniting with your biological families!


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Ellipticle Trainer
- High quality magnetic resistance with 8 levels of workout
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- Large anti-slip platforms (Non Slip Platform)
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- Weight Capacity: 220 lbs.
$187.27 -
Deluxe Aerobic Step
Sunny Distributor Inc., located in Los Angeles, U.S.A., is a professional importer of Health and Fitness products. Our products are imported directly from China and Taiwan. They guarantee to provide products with the lowest price and highest quality. The improved and new aerobic Stepper is the cheapest and simple way to lose weight, burn calories, and strengthening and toning muscles in legs and buttocks. Since for many people any kind of Exercises can be boring, you really can entertain yourself watching tv with this stepper because it is light weight and can be moved to any room in your home or office. Non-slip surface. Stepping surface: 14 x 39. Adjust from 4 to 6 to Supports up to 200 lbs$52.99 -
NFL Tailgate Keg
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Discussion about math, puzzles, games and fun. Useful symbols: ÷ × ½ √ ∞ ≠ ≤ ≥ ≈ ⇒ ± ∈ Δ θ ∴ ∑ ∫ π -¹ ² ³ °
| |
You are not logged in. #1 2011-04-12 16:34:12
Requiring Algebra II in High SchoolAn article from the Washington Post: http://www.washingtonpost.com/business/ … story.html "The physicists defer only to mathematicians, and the mathematicians defer only to God ..." - Leon M. Lederman #2 2011-04-12 17:55:30
Re: Requiring Algebra II in High SchoolHi;
That is the kind of guy I have seen for the last 75 years. Next he will assert that although there is a correlation between education and good jobs we should not jump to conclusions!
Amazing! Someone in the US is not going to lower standards! What! Have they no understanding of parody? After all even the creature from the black lagoon has the right to attend our schools and do as well as anyone else. In mathematics, you don't understand things. You just get used to them. Some cause happiness wherever they go; others, whenever they go. If you can not overcome with talent...overcome with effort. |


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I have large pst files which I need to split into smaller pst files. Is this something that can be done? Where the split pst files remain usable in outlook.
This MS KB Article has steps to do so in Outlook 2007 method 3 Your best bet would be to transfer your file to a computer that has 2007 and use one of these methods. This will allow you to work on a backup copy as well as you won't have to buy a third-party application to do it. Regardless, always work on a backup OR Please forgive my formatting, trying to keep it in a quotation block |
Mentioned (by @Raystafaian) methods are not flexible and way too complex than using free Split Storage utility. All you need is to specify source storage (your connected PST), destination folder for resulting PST files and desired PST file size. You can also split your PST files by years using this tool. I recommend this freeware product because I'm one of its developers and this way actually splits PSTs automatically without need to manually copy items. |
protected by Community♦ Aug 23 '12 at 7:57
This question is protected to prevent "thanks!", "me too!", or spam answers by new users. To answer it, you must have earned at least 10 reputation on this site.


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Reviews, reviews, reviews...
FreakScore is a weighted average of all aggregated professional and user review scores. Read more
This product has a FreakScore of 6.8* out of 10 based on 2 scores.
*Score is uncertain and deviates toward category average due to low number of scores.
The Labtec® Media Desktop enhances your entire PC experience—in Read more
Best Price at Amazon


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Crack Leave-In Hair Cream 2.5 oz.
Penny W.LebanonHairAuburnColor Treated HairThick or Coarse HairLove This Product!!!I am so addicted to this product since I received a sample. I had to have it immediately!
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Robin W.Wichita, KansasHairWhiteDry HairColor Treated HairI Didn't Think My Hair Could Be This Soft!As a woman in my late 40's, with color treated hair, that I have to straighten every day, I was in search of something to make my hair feel and look healthier. I saw this Crack Leave-In Hair Cream in an e-mail that I received from Folica.com, and after reading all the wonderful reviews, I decided to take a chance on it. I AM SO GLAD THAT I DID!! After the first day I used it, my hair felt so much softer, and it didn't take me as long to get it straightened that morning. I don't have curly hair, but I have layers that are growning out, and some days, I feel like my hair is going in 20 different directions. This seemed to help smooth it out, and make it much easier to get the look I am going for. I am due to get my hair colored and trimmed again this week, and I am taking it along with me for my stylist to try as well :)posted Feb 18, 2014Link to this post
Penny W.LebanonHairColor Treated HairThick or Coarse HairLove This ProductI received this as a sample and loved it. Had to buy it immediately. I have very, very coarse, color treated hair and have tried far to many products to list to try to get my hair smooth and not frizzy. Nothing ever worked like it claimed to until I tried Crack. This is my new miracle product. Thank you for sending me a sample to try. Love this product!!posted Feb 10, 2014Link to this post
MelissaPAHairMedium BrownFine or Thin HairRelaxed HairChemically Treated HairToo ThickI have found that this product is too thick for my hair. I have fine hair that is chemically treated/relaxed and colored. I use a blow dryer and flat iron every three days. I read the reviews on this product and decided to give it a try. I carefully monitored the amount I used and was not pleased with the results - using the product alone. When used in combination with Argan oil it seemed to work much better - but honestly did not produce results that were significantly different than using the Argan oil alone. I am glad I tried it, but overall I am not that impressed with the results.posted Feb 5, 2014Link to this post
ReHairDark BrownThick or Coarse HairRelaxed HairI'm Addicted To Crack!!!I have overprocessed/relaxed hair. I deep condition my hair regularly but as soon as I blow dry and run my hair through the flat iron it is dried out and tired looking... until crack! I was amazed at how well it performed. A little goes a long way. My hair was shiny and soft. People keep asking me if I am taking vitamins because my hair is so healthy looking. My 13 year old daughter also uses it on her spiral curly hair and has the same results. Worth every penny!posted Jan 24, 2014Link to this post
Ella F.United StatesHairGreyThick or Coarse HairOutstandingCrack combined with Sedu Anti-Frizz is the bomb-dot-composted Oct 29, 2013Link to this post
Paresh B.New YorkHairBlackCurly HairFlat IronI was skeptical about buying this but I have no regrets! It only takes a very small amount to get my hair straight, smooth, and shiny! I've only used it before blow drying my hair but I think it work great it you just let your hair air-dry too. It smells great too! I love that this product is a multi-tasker as it replaces a leave in conditioner,posted Oct 1, 2013Link to this post
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text: Mormon trek tests strength and courage on Jericho Trail By Mary B. Johnston Special to The Gazette Thursday, April 18th, 2013 Text size: A A A Tweet Back To Story Laurel Johnson/Special to The Gazette -- Young trekkers pulled handcarts over 19 miles of muddy trails in the Francis Marion Forest. From left to right, Natalie Lockman, 16, Mount Pleasant; Lexis Turlock, 14, Goose Creek; Sullivan Castrate, 15, North Charleston; and Jett Whitten, 16, Mt. Pleasant. --


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Ocean Currents and Weather *
*Note: This is an abbreviated Project Idea, without notes to start your background research, a specific list of materials, or a procedure for how to do the experiment. You can identify abbreviated Project Ideas by the asterisk at the end of the title. If you want a Project Idea with full instructions, please pick one without an asterisk.
Ocean currents have a huge impact on our weather. If not for the ocean currents, the global climate would be similar to an ice age. Do you live near the coast? Find out which currents are near your coastline. How do they affect your climate? Where do they come from? Do they bring colder or warmer water to your area? Are they seasonal? What do you think your area would be like without them? Every three to seven years there is a weather phenomenon called El Niño, which is caused by a shift in ocean currents. Are there weather patterns that can be attributed to El Niño? Do weather histories reflect an increase in blizzard/hurricane/flooding frequencies during El Niño years? What about before or after El Niño Years? (FI, 2006; GLOBE, 2006; NCAR, 2006; NOAA, 2006; Unisys, 2006; Weather Underground, 2006; WMO, 2006)Share your story with Science Buddies!
I Did This Project! Please log in and let us know how things went.Last edit date: 2013-01-10
- FI, 2006. "Franklin's Forecast," The Franklin Institute. [accessed: 3/1/2006] http://www.fi.edu/weather/.
- GLOBE, 2006. "The GLOBE Program: Measurements: Protocols," GLOBE, managed jointly by UCAR and CSU. [accessed: 3/1/2006] http://globe.gov/fsl/html/templ.cgi?measpage〈=en&nav=1
- NCAR, 2006. "NCAR Science and Education Outreach Page," National Center for Atmospheric Research. [accessed: 3/1/2006]
http://eo.ucar.edu/. - NOAA, 2006. "NOAA Homepage," National Oceanic & Atmospheric Administration, U.S. Department of Commerce. [accessed: 3/1/2006] http://www.noaa.gov/.
- Unisys Corp, 2006. "Unisys Weather," Blue Bell, PA. [accessed: 3/9/2006] http://weather.unisys.com/.
- The Weather Underground, Inc, 2005. "The Weather Underground," Ann Arbor, MI. [accessed: 12/13/05] http://www.wunderground.com/.
- WMO, 2006. "World Meteorological Organization," WMO, United Nations. [accessed: 3/1/2006] http://www.wmo.ch/index-en.html.
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This beautiful ring is set with an intensely colored peridot oval-cut center stone that is framed in brillant round diamonds. This intricately detailed ring is of 14K yellow gold.
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This article needs additional citations for verification. (August 2011) |
Scarifying (also scarification modification) involves scratching, etching, burning / branding, or superficially cutting designs, pictures, or words into the skin as a permanent body modification.[1] In the process of body scarification, scars are formed by cutting or branding the skin by varying methods (sometimes using further sequential aggravating wound healing methods at timed intervals, like irritation.), to purposely influence wound healing to scar more and not scarless. Scarification is sometimes called cicatrization (from the French equivalent).
Scarification is usually more visible on darker skinned people than tattoos. Endorphins can be released in the scarification process that can induce a euphoric state.[citation needed]
There are also aesthetic, religious, and social reasons for scarification. For example, scarification has been widely used by many West African tribes to mark milestone stages in both men and women's lives, such as puberty and marriage. It is also used to transmit complex messages about identity; such permanent body markings may emphasize fixed social, political, and religious roles.[2]
Scarring on the abdomen of women in many tribes is used to denote a willingness to be a mother. Her ability to tolerate the pain of scarring was an indication of her emotional maturity and readiness to bear children.[3]
Some groups in Northern Ghana like the Dagomba use scarification to treat certain ailments such as convulsions, measles, pneumonia, stomach pains, and so on. It is believed that these sicknesses originate in the blood, so the skin is cut by a traditional healer and powder or potion is then applied to the wound so that it may travel directly to the bloodstream. [4]
Most people in certain regions of Africa who have "markings" can be identified as belonging to a specific tribe or ethnic group. Some of the tribes in Northern Ghana who use the markings are the Gonjas, Nanumbas, Dagombas, Frafras and Mamprusis. [4]
Scarification is not a precise practice; variables, such as skin type, cut depth, and how the wound is treated while healing, make the outcome unpredictable. A method that works on one person may not work on another. The scars tend to spread as they heal, so outcome design is usually simple, the details being lost during healing.
Human branding is one type of scarification. It is similar in nature to livestock branding.
- Strike branding
- Similar to the process used to brand livestock,[5] a piece of metal is heated and pressed onto the skin for the brand. Historically it was used to claim ownership of slaves or to punish criminals, but as a form of body art, strike branding is less preferable to other types because it is not precise and tends to spread greatly on healing, and is not advisable for curved areas of the body. More successful is the multi-strike brand, done piece by piece rather than all at once. For example, to get a V-shaped brand, two lines would be burned separately by a straight piece of metal, rather than by a V-shaped piece of metal.
- Cautery branding
- This is a less common form of branding that uses a thermal cautery tool with a heated wire tip to cause the burns.
- Laser branding
- "Laser" branding is a marketing term coined by Steve Haworth, who pioneered its use in body modification. The technical term is "electrosurgical branding". Though it is technically possible to use a medical laser for scarification, this term refers not an actual laser, but rather an electrosurgical unit which uses electricity to cut and cauterize the skin, similar to the way an arc welder works. Electric sparks jump from the hand-held pen of the device to the skin, vaporizing it. This is a more precise form of scarification, because it is possible to greatly regulate the depth and nature of the damage being done to the skin. Whereas with traditional direct branding, heat is transferred to the tissues surrounding the brand, burning and damaging them, electrosurgery branding vaporizes the skin so precisely and so quickly that little to no heat or damage to the surrounding skin is caused. This means that pain and healing time after the scarification is complete is greatly lessened.
- Cold branding
- This rare method of branding is the same thing as strike branding, except that the metal branding tool is subjected to extreme cold (such as liquid nitrogen) rather than extreme heat. This method will cause the hair on the brand to grow back white and will not cause keloiding. This process is also used in livestock and called freeze branding in that context.
Cutting of the skin for cosmetic purposes is not to be confused with self-harm, which is also referred to by the euphemism "cutting." There may be cases of self-mutilation and self-scarification for non-cosmetic reasons. Lines are cut with surgical blades. Techniques include:
- Ink rubbing
- tattoo ink (or another sterile coloring agent) is rubbed into a fresh cut. Most of the ink remains in the skin as the cut heals, and will have the same basic effect as a tattoo. As with tattoos, it is important not to pick the scabs as this will pull out the ink. The general public often interprets ink-rubbings as poorly done tattoos.
- Skin removal/skinning
- Cutting in single lines produces relatively thin scars, and skin removal is a way to get a larger area of scar tissue. The outlines of the area of skin to be removed will be cut, and then the skin to be removed will be peeled away. Scars from this method often have an inconsistent texture, although this relies heavily on the experience of the artist and aftercare of the wound.
- Packing
- This method is uncommon in the West, but has traditionally been used in Africa. A cut is made diagonally and an inert material such as clay or ash is packed into the wound; massive hypertrophic scars are formed during healing as the wound pushes out the substance that had been inserted into the wound. Cigar ash is used in the United States for more raised and purple scars; people may also use ashes of deceased persons[citation needed].
- Hatching
- similar in appearance to flesh removal this method of scarification relies on using a sterile surgical scalpel to cut into the skin. Where a larger area is required to be scarred you cut with a hatching technique similar to the sketching technique. This method is easier to perform than flesh removal and can be done with one hand which could be beneficial in some situations. While this technique can take longer for larger pieces it is useful for smaller, more detailed designs and enables shading to be used.
Scars can be formed by removing layers of skin through abrasion. This can be achieved using an inkless tattooing device, or any object that can remove skin through friction (such as sandpaper).
Chemical scarification uses corrosive chemicals to remove skin and induce scarring. The effects of this method are typically similar to other, simpler forms of scarification; as a result there has been little research undertaken on this method.
The common practice on healing a scarification wound is use of irritation.
- Irritation
- Generally, the longer for a wound to heal, the more pronounced the scar will be. Thus, in order to have pronounced scars, the wound may be kept open for a protracted time. This is by abrading scabs and irritating the wound with chemical or natural irritants such as toothpaste or citrus juice. Some practitioners use tincture of iodine which has been proven to cause more visible scarring (this is why it's no longer used for treating minor wounds). With this method, a wound may take months to heal.
- Keloids
- Keloids are raised scars. Keloiding can be a result of genetics, skin colour (darker skin types are more prone to keloiding), or irritation. Keloids are often sought for a visual, 3-D effect and for tactile effects.
- If an enclosed area perimeter is cut or branded, the skin inside the closed space may die off and scar due to a lack of blood flow.
- Touch-ups
- If a scarification does not heal to yield a prescribed outcome, secondary scarifications may be conducted.
An alternative view is described by the acronym LITHA, meaning Leave It The Hell Alone. In body modification this is often considered the best way to reduce the risk of infection and the pain of healing.[citation needed]
Scarification produces harm and trauma to the skin; thus it is considered to be unsafe by many. Infection is a concern.[6] Not only does this hurt, the materials for inducing the wounds need to be sanitary, but the wound needs to be kept clean, using antibacterial solutions or soaps often, and having good hygiene in general.[7] It is not uncommon, especially if the wound is being irritated, for a local infection to develop around the wound. The scarification worker needs to have detailed knowledge of the anatomy of human skin, in order to prevent tools cutting too deep, burning too hot, or burning for too long. Scarification is not nearly as popular as tattooing, so it is harder to find workers experienced in scarification. Precautions are made for brandings, such as wearing masks, because it is possible for diseases to be passed from the skin into the air when the skin is burning, that can lead to death from the tool they use.
See also[edit]
- ^ Brighton Journalism – The new craze in body modification
- ^ "Scarification and Cicatrisation among African cultures". Rand African Art. Retrieved 2012-10-17.
- ^ "African scarification to decorate and beatify the body". Ezakwantu.com. Retrieved 2012-10-17.
- ^ a b "Scarification: Leaving your Mark". Travel Blog. Retrieved 2012-10-17.
- ^ National Geographic – Scarification: Ancient Body Art Leaving New Marks
- ^ Brighton Journalism – The new craze in body modification[dead link]
- ^ Daily Reveille – Scarification making its mark on society[dead link]
External links[edit]
Wikimedia Commons has media related to Scarification. |
- Pictures of scarification in Africa – Features by Jean-Michel Clajot, Belgian photographer and Saï Sotima Tchantipo Doctor Anthropology
- Extensive Scarification Article – Features different scarification techniques and advice
- The Medical Museum: University of Iowa Health Care: Body Alterations
- Body Modification E-Zine
- Scarification entry in BME Encyclopedia
- Scarification Blog at Scarwars.net


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Childrens | Color: Black | Style Number: 181467
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1. Create step card base out of light blue cardstock.
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Dr. Niendorf is a third-year Radiology Resident at Beth Israel-Deaconess Medical Center, Boston, MA. Prior to residency, he completed his MD, PhD at the University of Wisconsin, Madison, WI. His PhD dissertation developed a magnetic resonance imaging method to measure single kidney glomerular filtration rate. He plans to begin an MRI fellowship after he completes his residency.
Angiogenesis is essential for tumor development. Assessing the response of tumors to new cytostatic treatments, such as anti-angiogenesis agents, requires functional evaluation of the tumor vasculature, in addition to the traditional measures of tumor size. Magnetic resonance perfusion imaging (MRPI) can provide exogenous and endogenous tracer methods to generate information about tumor vascular characteristics such as permeability, perfusion, and blood volume. As a result, MRPI is a critical tool for investigating the efficacy of new therapies and, specifically, for monitoring tumor response to therapy.
Angiogenesis has emerged as a compelling physiologic model in the description of tumor vascular development. Angiogenesis refers to the stimulation of new vessel growth, or neovascularization. This process occurs as part of normal development and during normal remodeling processes, such as in wound healing and in the heart in response to myocardial ischemia. 1 Increased angiogenic activity is implicated in a variety of disease states as well, including diabetic retinopathy, endometriosis, and certain dermatological disorders such as psoriasis. The influence of angiogenesis on cancer has stimulated the development of anti-angiogenesis agents as a major focus of contemporary research.
Assessing the response of tumors to anti-angiogenic treatment presents challenges. Traditional imaging methods have typically employed size measurements as an index of response to tumoricidal agents. 2 Size measurements alone will be less effective when using treatments geared toward a cytostatic effect. At present, the use of clinical parameters, such as quality of life assessments or meaningful impacts on longevity, as measures of response has limited value and is difficult to standardize. Therefore "functional" or "physiologic" imaging techniques have been developed to assist in the evaluation of in vivo response to anti-angiogenic therapy.
Recognizing the increased importance of anti-angiogenesis treatments for tumors throughout the body, this article is aimed toward developing 1) an understanding of angiogenesis and its role in tumor development, 2) an understanding of the problems associated with monitoring the response of tumors to anti-angiogenesis therapy, and 3) an appreciation for the role of magnetic resonance perfusion imaging (MRPI) techniques as they pertain to evaluating neoplasms.
In the early stages of development, neoplastic cells rely on the diffusion of sustaining substances from the existing host vasculature to survive. 3 The efficacy of this process limits the size of tumors to several cubic millimeters. In order for tumors to continue to grow, neovascularization is critical. Typically by the time a tumor can be resolved via conventional screening methods, it has expanded into the neovascularity phase. 4
Angiogenesis has been described using a four-stage model: stimulation, growth, vessel formation, and stabilization. Cell neovascularization is typically controlled by a balance between angiogenic and anti-angiogenic factors. 5 A combination of various stimulating factors can influence angiogenic pathways and weight the balance to upregulate angiogenesis--ie, stimulate growth of endothelial cells in existing microvessels. Stimulating factors can include those related to the microenvironment, such as hypoxia, in-creased lactic acid, and decreased pH. Stimulated endothelial cells then break down the vessel basement membrane via secretion of proteases in order to allow growth toward the tumor. 6 The newly sprouting cells form a capillary loop and canalize to form a new vessel. Stabilization of the new vessel is the final step in neovascularization. However, this step may be defective in tumors, allowing prolonged increased permeability, as has been demonstrated in many cerebral neoplasms. 7
Since Folkman first suggested the angiogenesis model in tumor development in 1971, increasingly complex pathways for stimulating angiogenesis have been discovered. 8 Many different factors affect the balance between promotion and inhibition of neovascularization. The process may be heterogeneous within individual tumors, with multiple coexistent "stages" resulting in the tumor's use of numerous angiogenesis-stimulating factors for continued growth. 9 In addition to allowing neoplastic growth, angiogenesis may propagate metastasis by providing prolonged access to circulation via the increased permeability of the neovasculature or by allowing tumor cells to escape into the circulation during the proteolytic stages of angiogenesis. 10
One of the most well-studied angiogenic factors is vascular endothelial growth factor (VEGF), which regulates vascular permeability and activates endothelial cells. Modulators of VEGF and other angiogenic factors have been proposed for controlling the neoplastic process. A variety of agents are being developed to target distinct stages of angiogenesis. A few mechanisms include inhibiting the initial stimulation of angiogenesis, blocking proteolytic activity, and affecting endothelial cell survival or proliferation. 11
There are several proposed clinical uses of these agents: prophylaxis in patients with a family history of cancer or those harboring premalignant lesions; adjuvant therapy in combination with traditional chemotherapy, radiation therapy, or surgery; and induction of sustained cancer remission. 12 While the possibility for implementation of single-agent anti-angiogenesis treatment has been raised, the success of preliminary trials with this approach has been limited. This has prompted continued development of new and combined anti-angiogenic therapies. 13,14
Standard approaches to assess tumors capitalize on the outstanding soft-tissue contrast and sensitivity to contrast media inherent to MR imaging to determine size, enhancement characteristics, and soft-tissue interfaces. MRI is also being employed to noninvasively obtain complementary functional information. In this regard, MR methods directed toward the evaluation of tumor vascularity and angiogenesis represent an important focus of active research. For this purpose, several MR techniques are capable of providing physiologic information, including: MR perfusion imaging, MR spectroscopy, diffusion imaging, and BOLD (blood-oxygenation-leveldependent) imaging. 15
MR perfusion imaging is a general class of techniques that can be used to evaluate tumor vascular characteristics such as blood flow, plasma volume, permeability, and mean transit time. 16 The information provided by MRPI is often related to a combination of several of the above tumor characteristics and is influenced by the particular MRPI technique being used, the qualitative tumor vascular characteristics, and the properties of the contrast mechanism (endogenous or exogenous). Understanding the nature of the information provided by MRPI is itself an area of active investigation using various tumor models, contrast agents, pharmacokinetic models, and MR imaging techniques. Nonetheless, MRPI data appear to at least provide useful surrogate markers of tumor biologic activity and will likely play an expanding role in tumor assessments. 17 For this reason, MRPI data are being used to investigate pathways of angiogenesis, help monitor the response of tumors to anti-angiogenic therapy, determine anti-angiogenic therapeutic dose during early phase trials, aid in the development of combination therapy regimens, provide a prognosis based on predicting tumor grade, and assist in the selection of biopsy sites within heterogeneous lesions. 18,19 Thus, MRPI can contribute to the preclinical research, clinical research, and clinical application phases of anti-angiogenic therapy development. 3
MR perfusion imaging represents microvascular flow through tissue--ie, the capillaries and venules. When tracers that distribute extravascularly, such as gadopentetate dimeglumine (Gd-DTPA), are used, MRPI clearly depends on the inflow or outflow of blood, but overall enhancement of tumors depends on several additional variables, including vascular permeability, extravascular extracellular volume fraction, and local blood pressure or impedance. 20
The perfusion or blood flow (BF) through a tissue, typically given as a volume flow rate normalized to tissue mass, is related to the intravascular blood volume and the mean transit time (MTT) of blood through the tissue, as follows:
BF [ mL · min -1 · g -1 ] · MTT [min] = BV [ mL · g -1 ]
(Equation 1)where BV represents the microvascular blood volume. MR perfusion imaging methods are intended to derive BF and BV using pharmacokinetic models, and thus allow estimation of MTT . It has already been shown that microvascular blood volume (BV) reflects the micro-vascular density (MVD) of the tumor, the latter being a useful parameter for determining prognosis. 19,21,22
Blood flow can show variability among different tumor types, as well as within a particular lesion. This variability in flow is most obvious when considering tumors with arteriovenous shunting and extremely slow flow. 23-25 Vascular permeability may also be highly variable, depending on tumor type and neovascular maturity. The spectra of both microvascular volume flow rates and permeability present challenges to modeling tumor enhancement; not only may both coexist within a single heterogeneous lesion, but both may also vary in time in response to therapy. 26 For example, a tumor may exhibit paradoxical response with reduced permeability but increased blood flow, and thus demonstrate little, if any, change in overall enhancement. Therefore, it is important to derive values for individual components of the process.
MR perfusion imaging techniques utilize exogenous or endogenous tracers to reflect perfusion. The most commonly used exogenous tracers are low-molecular-weight contrast agents such as Gd-DTPA. However, macromolecular, "intravascular," and receptor/targeted exogenous agents are being investigated to provide further insight and flexibility in evaluating perfusion and MVD. 27 Endogenous methods typically utilize water protons within blood as a tracer, and thus rely on mechanisms intrinsic to MR technology. Relevant examples of endogenous MRPI methods are arterial spin labeling (ASL) and BOLD imaging.
Exogenous MRI techniques
Exogenous, or dynamic contrast-enhanced (DCE) MR imaging methods rely on the pharmacokinetics of contrast agent uptake within the tumor. In preliminary studies, exogenous methods have been used to demonstrate the efficacy of anti-angiogenesis agents in a sarcoma model 28 and in breast cancer. 29 Imaging sequences with T1-, T2-, and T2*-weighting can be used. While low-molecular-weight contrast agents have found the most widespread clinical use, macromolecular, super-paramagnetic and targeted receptor contrast agents are being developed. Quido et al 30 have compared the use of clinically approved low-molecular-weight gadolinium chelate agents with various ultra-small super-paramagnetic iron oxide (USPIO) agents using a T1-weighted technique in a colon carcinoma model and found that clinically approved gadolinium chelate agents may be recommended due to T2* effects using the USPIO agents. However, Bremer et al 31 found the use of USPIO agents feasible in a variety of tumors using a proton-density imaging sequence. Kobayashi et al 32 also found the use of macromolecular contrast agents to be useful in several tumor models.
T1 imaging methods can be used at lower contrast agent concentration, while T2* effects predominate at higher concentration and cause rapid signal dephasing. Figure 1 demonstrates the initial increase in signal intensity corresponding to an increase in Gd-DTPA concentration when using a T1-weighted sequence with a variety of flip angles. Signal differences between the curves depend on relative T1-weighting due to selected flip angle. This figure also demonstrates a peak and then decline in signal intensity at higher Gd-DTPA concentrations. Commonly used T1-weighted imaging methods include inversion prepped "fast spoiled gradient-recalled echo" (FSPGR) and "fast low-angle shot" (FLASH) techniques. Echoplanar imaging (EPI) methods are commonly employed to exploit T2 or T2* effects during perfusion imaging.
Many pharmacokinetic models have been proposed in order to interpret the signal intensity changes observed following contrast agent administration. It is important to note that each pharmacokinetic model has certain assumptions that may introduce errors into the analyses. Nonetheless, information can be ascertained that at least provides surrogate markers of the physiology, such as estimates of perfusion and permeability. 17,33 For example, MRPI was recently used to correlate vascular permeability to biologic aggressiveness in ovarian carcinomas. 34 Two commonly used models are briefly described to demonstrate contrast-enhancement pharmacokinetics: one- and two-compartment models.
The most basic model, the one-compartment model, assumes that the intravenous contrast agent immediately achieves equilibrium among all accessible compartments, such as the intravascular, intracellular, and extravascular extracellular compartments (Figure 2). The concentration of the contrast agent within the tumor or region-of-interest (ROI), C(t) , is then described by simple exponential decay as it is eliminated:
C(t) = C 0 · e -K e (t)
(Equation 2)where C 0 is the initial concentration and K e is the elimination rate constant. 17 This model can be used in the two theoretical extremes of first-pass contrast agent behavior: complete permeability, with 100% extraction of the tracer; or with no extraction of the tracer (ie, purely intravascular agents). These extremes would allow straightforward determination of vascular permeability ( PS * ) and BF, respectively. However, commonly used low-molecular-weight agents have variable extraction in tumors, thus complicating pharmacokinetic modeling. 35,36 For this reason, other models such as the two-compartment model are often employed.
The two-compartment model accounts for distribution of the contrast agent within the intravascular space and within a second, readily available space, such as the extravascular extracellular space (Figure 3). In this case, the permeability represents the net exchange rate between the capillary and extravascular extracellular compartments ( PS * ). Two equations represent the time rate of change within the intravascular and extravascular extracellular compartments:
Intravascular compartment:
v * dCp = F * (C a C p ) PS * (Cp C e )
(Equation 3)Extravascular extracellular compartment: v e dCe = PS * (C p C e )
(Equation 4)where dC p /dt and dC e /dt represent time rate of change of concentration within the capillary and extravascular extracellular space respectively; C a , C p , and C e are the arterial, capillary, and extravascular extracellular space time-dependent concentrations, respectively; F * is the perfusion ( BF ); PS * is the permeability; v * is the fractional blood volume ( BV ) within a voxel; and v e is the fractional extravascular extracellular volume. 17,37 Since it is not possible to spatially resolve the capillary and extravascular extracellular space using MRI, the enhancement of a single voxel or ROI overlying a tumor represents the combined effects of enhancement in both of these compartments. By measuring arterial and tumor enhancement, it is possible to solve Equations 3 and 4 to obtain the two unknowns of capillary and interstitial concentration ( C p and C e ).
The challenges in designing an MRPI sequence and the ability to use a particular model depend on the temporal resolution of the imaging sequence, the ability to image an adequate region or volume of interest, the signal-to-noise ratio of the data, and the ability to measure the arterial input function ( C a ). 17,26 For example, using the two-compartment model, DCE MR imaging methods can be used to reflect permeability ( PS * ), perfusion ( F * or BF ), and blood volume ( BV or v * ). 38 However, signal-to-noise ratio limitations often make the two-compartment model difficult to fit. Also, the two-compartment model requires measurement of the arterial input function. This requirement may necessitate the acquisition of multiple slices in those circumstances in which it is not feasible to prescribe a single slice containing both the tumor and a major artery. Adequate temporal resolution is needed to resolve rapid signal changes within the artery following bolus contrast administration. If any of these conditions cannot be satisfied, a simpler model, such as the single-compartment model, must be used at the sacrifice of informational content.
Common DCE MR methods provide temporal resolution on the order of 1 to 2 seconds while imaging 1 to 2 slices. Contemporary multislice techniques can sustain satisfactory temporal resolution while improving volume coverage. For example, Hussain et al 39 explored the use of a T1-weighted sensitivity encoding (SENSE) time-resolved DCE method that provided 7-second temporal resolution while covering 24 image slices. Trade-offs between adequate temporal resolution and sufficient tumor sampling must be planned carefully.
Example of exogenous contrast imaging-- The following patient with known metastatic renal cell carcinoma presented with a suspicious posterior mediastinal mass and was evaluated using a T1-weighted DCE MR technique. Three coronal images of the posterior thorax from the temporal series of images acquired following Gd-DTPA administration demonstrate successive enhancement of the pulmonary vasculature, aorta, and tumor, respectively (Figure 4). An ROI analysis was applied to the aorta and tumor to provide arterial and tumor signal intensity data (Figure 5). The signal in the aorta demonstrates the bolus technique, or arterial input function ( C a ). The signal in the tumor increases shortly after the arterial phase, and delayed enhancement is due to vascular permeability. The signal intensity data were then curve-fit using Equations 3 and 4 to provide estimates of permeability and perfusion.
Endogenous MRI techniques
Endogenous, noncontrast-enhanced, or intrinsic MR contrast methods can reveal information about the tissue vasculature without exogenous contrast administration. While endogenous methods generally suffer from lower contrast-to-noise ratio and motion sensitivity compared with exogenous methods, advantages include insensitivity to vessel permeability, lack of IV contrast administration, 20 and the ability to perform repeat studies. Although it is possible to give a second dose of gadolinium when using exogenous methods to accomplish repeat or additional studies, each additional contrast bolus greatly complicates pharmacokinetic modeling. In contradistinction, ASL has no cumulative residual effect. Thus, ASL offers the possibility for an unlimited number of sequential studies to replace poor-quality data (eg, poor breath-holding) and to assess response to a variety of physiologic challenges (eg, administering O 2 or CO 2 ).
Two examples of endogenous methods are ASL and BOLD imaging. 40 Arterial spin labeling relies on movement or inflow of water molecules with a different radiofrequency (RF) pulse history from the surrounding stationary tissue. Since ASL does not utilize a bolus contrast administration, no arterial input function is required. In general, ASL methods utilize RF pulses to create signal contrast between inflowing spins and surrounding stationary tissue. There are two general classes of ASL: continuous and pulsed methods.
Continuous methods are used predominantly in cerebral imaging and involve a continuously applied spatially selective "tagging" RF pulse inferior to the slice of interest in the brain, relying on inflow of "tagged" spins into the ROI. These images are then subtracted from a control image in which no RF "tagging" pulse is applied to obtain the final images (Figure 6A). Subtraction is performed to suppress the signal of background stationary tissue because the relative signal changes due to inflow of tagged spins is small (on the order of 1% to 2%). 20,41 It is often not possible to use continuous ASL techniques in body imaging due to high RF amplifier requirements, 20 and this has prompted the use of pulsed ASL techniques for body tumor assessments. Pulsed ASL suffers from reduced signal-to-noise ratio compared with continuous techniques.
Pulsed ASL also involves subtracting a control image from a "tagged" image, with two commonly used techniques: EPISTAR (echoplanar imaging and signal targeting with alternating radiofrequency) and FAIR (flow-sensitive alternating inversion recovery). In EPISTAR, the "tagged" image is acquired following a "tagging" RF pulse over a region upstream to the imaging slice. The control image is obtained following a similar "tagging" pulse in a downstream location where "tagged" spins are unable to enter the image slice. The control is acquired in this fashion to allow subtraction of magnetization transfer effects by the initial "tagging" pulse. 42 Again, the final image is obtained by subtracting the control from the "tagged" slice (Figure 6B). Alternatively, FAIR ASL is performed by subtracting an image acquired following a nonselective RF tagging pulse from an image acquired following a selective inversion centered on the imaged slice (Figure 6C). 20
Blood-oxygenation-leveldependent imaging methods rely on contrast related to the paramagnetic properties of deoxyhemoglobin. Deoxyhemoglobin enhances the rate of energy transitions between hydrogen nuclei ("spins") in its immediate vicinity, thus decreasing T2 (or T2*) and creating more rapid signal loss (ie, dephasing of the transverse magnetization). Intuitively, BOLD imaging is appealing for evaluating angiogenesis, since regional hypoxia is a possible stimulus of angiogenesis. However, application for evaluating neoplasms is still poorly understood. 40 Blood-oxygenation-leveldependent contrast may depict changes in blood volume or oxygenation by comparing images acquired at baseline to images acquired during oxygen administration (hyperoxia). 40 Tumors demonstrated high signal enhancement in response to hyperoxia. 43 Blood-oxygenation-leveldependent im-aging has also been applied to map changes in blood volume fraction and vascular functionality associated with angiogenesis. 44
Example of endogenous contrast imaging-- The following patient presented with retroperitoneal lymph-adenopathy related to metastastic renal cell carcinoma and was evaluated using a FAIR ASL technique (Figure 7). Figure 7D is an axial T2-weighted image provided to demonstrate retroperitoneal lymphadenopathy. Figures 7A and 7B represent ASL images acquired in the same axial imaging plane with nonselective and selective RF tagging pulses, respectively. The final subtracted ASL image (Figure 7C) demonstrates enhancement of multiple retroperitoneal lymph nodes, with relative suppression of surrounding background tissue.
Angiogenesis, a crucial process involved in tumor growth, consists of interactions among numerous stimulating and inhibiting factors to influence the proliferation of blood vessels. Although many new anti-angiogenic therapies have been developed, the evaluation of tumor response to these new therapies presents challenges. MR perfusion imaging techniques can respond to these challenges by noninvasively providing surrogate markers of tumor vascular function. The expanding role of MRPI in evaluating tumors provides opportunities to improve our understanding of certain aspects of tumor physiology and to improve the care of patients undergoing antiangiogenesis treatments.
I would like to express much appreciation to Dr. Neil Rofsky for guidance and manuscript review. I would also like to express appreciation to Dr. Cedric deBazelaire and Dr. David Alsop for both discussions regarding many of the tracer kinetic modeling and MR concepts within this paper, and for allowing use of data and example images in Figures 1, 4, 5, and 7. Thanks also to Dr. Jonathan Kruskal for recommending angiogenesis reference material, and to Michael Larson for assistance with preparing figures.


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Hot answers tagged door-frame
Not only besides RH or LH, you need to determine swing direction. Trust me, this needs to be agreed upon. When I built the additional room onto my house, I thought 84 Lumber understood the direction of door swing and they didn't. There is left inswing, right inswing, left outswing, and right outswing.
The door handle on my exterior door is on the right-hand ...
As a homeowner, I have installed many doors, and every time I do I have to re-learn how to "determine door swing". Just make sure you write it down before you order the door, it is easy to get confused again when you go to your local home improvement store. This website should help:
First, the ...
If you're having the same problem I had, and it's a case of rubbing but the door could be forced closed (so it's just slightly off), I just made a note of where it was rubbing with a bit of crayon (wipes off easily), then took a small hand plane to shave down that area slightly.
Unfortunately, I also made the mistake of passing off the plane to my house ...
I guess you could try putting some thin foam or felt stick on pads on the inside of the door frame where the door contacts it. This should lower the sound of the wood to wood contact. If the knob hardware is also loud, try using some dry silicon spray lubricant on the moving parts and on the door hinges. Sleep well.....
Bifold rough openings: to the hinge (pivot ) side add 3/4", to the other other side, 1/4"
So for single 24" wide door, a 25" RO (which is really a finished opening for bifolds) is needed.
You need a bit more clearance on the pivot side, because the pivot is inboard a bit and it needs clearance to swing through (pivot around) the thickness of the door. ...
My two cents worth..... We always install the base trim and door trim first. If you have split jam doors with the casings already attached, you must install them first or you will have a real problem fitting the jams to the floor between rooms. As mentioned, sometimes the carpet installers can scratch the finish on the baseboards, however it is usually ...
From International Residential Code, your local planning department is the final authority on what may or may not be done after inspecting what modifications you are intending to do. This is a job that requires a permit and consultation with an experienced contractor.
R802.7.1 Sawn lumber. Notches in solid lumber joists, rafters, blocking and beams shall ...
I agree with Jeff Widmer -- you don't need a bigger/stronger bracket, as it's not the bracket that failed, but longer screws to properly fasten the bracket.
Given that, your jamb repair doesn't need to be structural so don't sweat how strong it is and just make it look nice with whatever product you've used before and liked. After you drill your pilot ...
It makes it easier for the carpet installer because they don't have the baseboards in the way when they're nailing in the tack strips next to the wall.
On the other hand, it makes things a little more difficult to install the baseboard later because the carpet and tack strips are in the way when you're trying to nail the baseboard to the sole plate in the ...
Your plan to fix the gap in the center of the door sounds fine. I might suggest using some shingle shims instead of flat stock however. If you want to just remove the interior trim only, that is fine also. Using the shingle shims, place the thickest end in first and by trial and error, adjust the opposing shim to a size that will snug in nicely and then by ...
First of all, some terminology.
What you want to replace is called the JAMB.
You can either replace the whole thing (prefered) or try and fit a smaller piece in to fix the broken area.
With a utility knife, score the paint on both sides of the STOP (The thin piece that stops the door when it is closed.
Pry it off with a small prybar, slot screw driver ...
You should definitely not cut those beams! They are massive because they carry the load of whatever is above you. If you want to modify the structure to carry that weight elsewhere, that is possible but you will need to get help from someone who knows how to safely modify structure and you will need a building permit.
I'm guessing that sort of cost and ...
The closet doors are most likely listed in actual finished opening size. However it is a good idea to use a tape measure to check 100% for sure. Some doors are made a little oversize to allow trimming into final size for the specified opening size. Other doors may very well be made a small amount undersize to allow for the necessary clearances needed for a ...
There are lots of concerns I can think of (this is a much bigger project than simply cutting a rectangle in the wall):
Exterior walls are load bearing, so you need to construct a header, king, and jack studs, to properly transfer the load over the door. During construction of this, it's a good idea to install temporary bracing.
Any utility lines in the ...
There's no such thing as US building codes, there are state, county, and municipal codes which vary widely between areas. The only way to know is to ask, which is what I'd recommend you do. There's no harm in it, simply call the office that is responsible and ask. You don't have to say you've already done it if you're worried about it, you could say you are ...
Can you just use longer screws? The screws would not only go through the damaged wood but also into whatever support is behind it. Of course this would not work if you have a side light on that side.
The other thing to consider is not using a storm with a double closer, but just one on the bottom (although you may have a reason for the double closer).
I can think of two options using the prehung doors available in HI stores:
You can pull the door apart (they come in two pieces for the installation) and cut about 3/4" off of the inset part of the door. Since this side goes into the channel on the other half of the door, you'll never see it if the cut isn't pretty. I believe there's at least 1/4" of play ...
The short answer is longer screws, plus some glue.
There should be plenty of extra room for longer screws on both the door and the jamb. If the hinges are brass, solid brass screws are best. At the same time stick in a small strip of wood soaked in wood glue into each hole just to be sure. Toothpicks, chopsticks or similar dry wood work well.
For bonus ...
Reline your jamb with another material that you can screw into. The pressure you will subject the door frame to is really needing something screwed into it. To just use pressure has the strong possibility of deforming or worse, cracking your jamb, depends on where the shims are placed behind the jamb, but you cant see them, unless you take it apart, not a ...
The loose base is causing catching at the opposite corner because the entire door and frame is pivoting around the upper hinge and nearby framing that is presumably still attached firmly to the jack stud behind the frame. As the bottom left part of the frame swings out, the upper right of the door is moving up to where it hits against the frame there.
Take ...
Ok Kenny, here is the plan. You can remove one Jack stud and door header with a sawzall(cutting between the studs to cut the nails) and some work. You can then replace the jack stud with a 3/4" board cut to 3 1/2" width and the new 3/4" higher height. Put a 3/4" block on top of the remaining jack stud and reinstall the header 2X4. It will still fit between ...
What I would do if it is hitting on the latch side is to remove a screw on each hinge in the middle of the hinge and replace it with a screw that is about 3½" to 4" long. Tightening these screws will pull the jamb in on the hinge side giving your door room to close on the latch side. Try it.
I'm not sure about ChrisF's suggestion since I've never had that particular problem (with the door rubbing on the hinge side) - is the issue that it's hitting the frame on the hinge side or the doorknob side?
If it's hitting the jamb on the doorknob side (as if the door is now too wide) then the usual solution is to trim down the door. Usually I would run ...
How do I go about fixing this? I guess I could take them off again, and chisel away a little on the door grooves or in the frame,
That's pretty much the only way - but take a good look and work out which side (door or frame) needs to move and in which direction. I've done this in the past and gone the wrong way at first which isn't good.
In some cases ...
I can't believe 3-6 inches is correct. Maybe 3/16 of an inch? (even that is pushing it).
The easiest way to fix this is to take the door down and trim a bit off the top of the door. I'll usually just run the door through my table saw to trim it down, but a power planer would probably work better if you have one. Otherwise a hand planer will work too, but ...
whether a door is an exterior or iinterior door the designation is the same. Think of RH as right hinge. if the door is swinging away from you the hinge is on the right side. for a left hinge door, if the door is swinging away from you the hinges are on the left side. Inswing or outswing only matters with exterior doors where they have a sill. The ...
It's best explained on this page:
Left Hand – Hinges on the left, opens inward.
Left Hand Reverse – Hinges on the left, opens outward.
Right Hand – Hinges on the right, opens inward.
Right Hand Reverse – Hinges on the right, opens outward.
You could clean it up, fill the cracks and gaps with Bondo or a similar filler, sand it smooth and paint it.
One approach is an oversized pre-cased, split-jamb door. These have casings (room side moldings) pre installed to the jamb and are attached separately from each side. The joint in the middle is hidden by the stop (the molding that the door actually rests against when closed). This is a home center site describing the process.
These doors probably would ...
I see in your picture that there is a wooden shim between the door frame and the jack stud. Typically the frame should be screwed into the jack stud separately from the door hinge. The small door hinge screws should only have to hold onto the frame of the door and usually don't need to be driven into the wall stud.
A fire door can be quite heavy though ...
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Brass Shutoff Valve
Heavy-duty brass shutoff valve protects hose fitting from leaks. Fits standard 3/4" hose fittings. USA made by Dramm®. View all Watering Equipment and Irrigation Supplies
2014 Master Catalog: Page 332
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Dramm Brass ShutOff Valve for 3/4" hose
By Love Quality
from Theresa, WI
About Me Master Gardener
Comments about Dramm Brass Shutoff Valve for Watering Handles:
Keep it on our hose end before any other attachment. It's the BEST on/off valve ever. The large lever is easy to switch on & off and being made of ALL Brass - it's very durable and heavy duty. Plastics just break in a short time. Not this ShutOff Valve. It's GREAT. I had one before for M A N Y years and first now needed a replacement. Plus I like that it is made in Wisconsin, USA !
would not buy again
By jb
from McHenry Il
About Me Avid Gardener
shut off so loose you just have to shake it to turn on/off
(2 of 2 customers found this review helpful)
Good news, Bad news
By NYBGer
from New York, NY
The longer shut-off lever is a definite improvement over the older Dramm models, BUT the design of these new versions does not allow the high-pressure streams of water that the older ones did. When the lever is fully opened now, the best you get is a feeble flop of water out the nozzle about 6 feet or so, vs. the high-powered jet you used to be able to get, which we need daily to spray plants/trees, 20-30 feet sometimes. Even when just watering plants, the new valve makes it feel as if your water pressure's taken a nosedive. Give me the old model any day!
Money well spent
By cjycjycjy
from Temple, PA
I do not understand why they do not add the large handled shut-off valve to other hose attachments such as the two-way or four way diverter.
Simply the BEST valve made
By Leicam6
from New Hope, PA
See all my reviews
Excellent for all your hose ends to allow for easy change between attachments


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