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Police say the suspect in the Provo Wells Fargo Bank robbery - went in at 10:10 Saturday morning. (See sequence of photos in slide show) He pulls out a gun and demands cash from the teller saying "Give me your money." He gets the money and quickly takes off. The total time in the bank 42 seconds. The robber is wearing sunglasses, a hoodie and bandana. That makes it hard to recognize him, but police are hopeful someone might see something familiar.
Unified Police are looking for a suspect who wasn't as quick or quick witted. Police say the man (See surveillance photo taken at nearby store) reached in through the drive through window at the Clean Express Dry Cleaners at 2945 E. 3300 S. in Millcreek. A worker chased him. When he caught up with the robber, the suspect then dropped the register and a cell phone and took off running.
And kudos to the cops who busted a couple of Cottonwood car thieves. Police were alerted by a neighbor who heard something around 3:30 in them morning near 7300 South and 2900 East. When police arrived the first suspect took off running. Police say he was dropping stolen items and jumping fences to get away. Police arrested 19-year-old Jett Rennert.
That's when cops spotted the second suspect hiding in a backyard. The unnamed juvenile was arrested after a brief struggle. If you know anything about the two unsolved robberies contact us or police and help catch a criminal.
Provo Police 801-852-7271
Unified Police 801-743-7000


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What Muffett and Skylar said (I think Muffett overstated)
(2013-04-08 00:51:22)
Edited on 2013-04-08 00:52:16
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In reply to:
What Geno and two players said (I talked to Dolson)
posted by NTGD
COACH MCGRAW: I'm just so proud of this team and what we accomplished this year and hate for it to end on a game like this when we just �� just played so poorly.
I thought Breanna Stewart was fantastic. She was just unbelievable. I think her and Lewis, obviously, just they killed us. And we contained everybody else, but we did not have an answer for them.
And defensively it's probably the most disappointing. I know we can miss shots, but I felt we could play better defensively. And that was a disappointing way for this really wonderful season to end.
But we will try to think back on what we did to get here and be proud of that.
Q. This question is directed to Skylar. You were not able to get a shooting rhythm, for whatever reason. Was your concentration then leaning more to getting your teammates involved and also playing defense, particularly the two blocked shots, you know, the defensive standard there? So those are the two questions to Skylar.
SKYLAR DIGGINS: Yes, it was. My focus was on defense and trying to distribute.
Q. Skylar, can you just talk a little bit about your legacy and just the entire Notre Dame experience.
SKYLAR DIGGINS: Well, it's been a dream come true, just having an opportunity to play for my hometown school and right in my backyard for Coach McGraw and just being able to learn from her every day. Just experiences I've gone through I'll never forget. The people that I met I'll never forget. And it was just such and great time. I had a great time going through it. And I wouldn't want a different group of girls in the locker room, I wouldn't want a different group of coaches.
And just the people I've met, I know they will be a part of my circle for life. And that's just a blessing in itself.
Q. Kayla, the full first ten minutes of the game you guys were 2 for 24 as a team. Was it the pressure of their defense or were you just missing makeable shots?
Q. You got off to �� I think it was 2 for the first 24. Was it the pressure of their defense or were you missing makeable shots?
SKYLAR DIGGINS: I thought it was a little bit of both. They did a great job of getting up and pressuring us, and I thought that we got some shots we wanted at the beginning of the game, some layups and some jumpers that we usually knock down.
It was a physical game tonight. I thought it was a little bit of both. You have to credit their defense and the pressure, making us take quick shots. But I thought we did get some shots that we wanted and usually knock down.
Q. Skylar, I think you guys had a 26-25 lead, Lewis went out about 2:55 left, and then they went on a 14-�3 run to close the first half. What happened there?
SKYLAR DIGGINS: We just didn't play good defense. And they got out in transition and they scored in half�court offense too. We didn't lock down on defense like we normally do. We just weren't playing like ourselves.
And, like I said, you have to credit them. They're such a good team, they know each other so well, and they outworked us.
Q. Skylar, can you share with us a little bit about what Geno said to you after the game?
SKYLAR DIGGINS: He just said don't let this game define my legacy. He told me that he feels like I've done more for the sport than some people who won four national championships. And he just told me that I've done a lot for the game of basketball and I had a great career.
Q. Coach, that first 15 minutes you guys couldn't hit anything, yet still a one-�point game. I gotta think you were thinking, OK, we're going to hit shots, eventually things are going to fall, we survived their defensive stop. What was the difference that got them going that you guys just couldn't really get anything going offensively all night?
COACH MCGRAW: I didn't feel good about it because we weren't executing anything. We weren't running our stuff. So we couldn't even feel good about that. We couldn't feel good about, oh, we got a great shot, we just didn't make it.
I thought we forced some things and overdribbled a little bit. We're a really good passing team, and I don't think we moved the ball. We missed some people that were open.
And so I don't think we got that confidence from executing.
Q. How does Skylar's legacy, her impact, affect next year's team, teams after that?
COACH MCGRAW: She leaves a gigantic hole in the lineup. I don't think any one person can replace her. I think that there's a lot of pressure on our incoming point guard to be good right away.
And I think the rest of the team has to step up a little bit more and realize what we've lost. I think that the swagger and the confidence that she brought �� I hope that somebody can step up and replace that.
Q. Muffet, obviously the game is disappointing, but I know how close you are with Skylar. I wonder if it's just disappointing �� or how disappointing is it to see her up here not to get to where I think she ultimately wanted to be?
COACH MCGRAW: I think she's a champion. I do. I know we didn't win it, but what she has done for us has been amazing and she's leaves Notre Dame as the most celebrated and decorated and best player ever, and I'm happy for that.
Insert: I believe Rurth Riley was Final Four MVP her senior season and overall national player of the year, so I am missing Muffet's point here. She'll surely walk this back a bit
Q. Muffet, you've played so assuredly all through the season, but especially in those games against UConn. Was it just maybe the importance of the moment or nerves? Is there any way to explain how poorly you shot tonight? It wasn't all defense, I don't think.
COACH MCGRAW: No, I thought we looked nervous. I did think we looked nervous coming out. And I think �� I don't know why we did. We've been here before, and we certainly should have felt differently. And I don't know. I think the way the game went early on, I just don't think we ever got into that rhythm where we could get comfortable, and so I think we were just a little on edge the whole time. And then all of a sudden we're down 10. And we just got in a giant hole at halftime, and the that really I thought was the difference in the game.
Q. Coach, you touched on it a little bit in your opening, Breanna Stewart was amazing tonight. How good was she considering she's a freshman under the big spotlight? How impressive is that to you?
COACH MCGRAW: It is really impressive to have a freshman have that kind of game, to be Most Outstanding Player in the Regional and then to come into the Final Four and just play with such confidence to be the best player on the floor �� well, on the team for Connecticut. You don't expect a freshman to rise to the occasion like that. So I thought a phenomenal performance by her.
Q. Muffet, did you say anything to Skylar, at least one-on-one after the game? Or there's obviously going to be time for that heading forward, but I wonder if you, as Geno did, said something to her?
COACH MCGRAW: No. We talked to the group in general
I think Muffett was emotional and "in the moment"
2013-04-08 07:14:07
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When Łukasz Firkowski and I began researching the Firkowski family in order to find out how we were related, I knew that the information that we put up on my website may attract relatives so we could expand our family knowledge, but I had not anticipated some other benefits that have occurred since then.
Our research has helped historians in Poland. The latest example of this is the inquiry I received the end of the summer last year by the curator of a Museum in Jelenia Góra, Poland.


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Pros: Good staff attitude. Good price, Good environment, Good common place
Cons: Not in market, about 15 mins away. Cleanliness is fine but walls/bathroom etc are OLD and needs some refurbishing (like painting, new tiles and all).
- Official Description (provided by the hotel):
- Cecil Hotel, Matheran is a Heritage Hotel constructed in the year 1950. Having been recently renovated and rejuvenated, it still maintains its charm of its era! Being a ground floor structure, it is an accessible hotel based in a sprawling area of 5.5 acres of land, lush green and quite for the ultimate tranquil holiday experience. The hotel consists of 25 rooms, including 3 bungalows and also a large dining room where the guests are served the most delicious vegetarian cuisine. The hotel also caters to the music savvy generation by providing an in-house dance floor and DJ. ... more less


text:
Vipul R. Panchal, MD is a Fellow in Interventional Cardiology at the Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN. He completed his General Cardiology Fellowship and his Internal Medicine Residency at the same institution. He received his MD from Northeastern Ohio Universities College of Medicine in 1996.
Vijay Kalaria, MD is an Assistant Professor of Clinical Medicine and an Associate Director of Cardiac Catheterization Laboratories and Interventions, Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN.
Jeffrey A. Breall, MD, PhD is a Clinical Professor of Medicine and the Director of Cardiac Catheterization Laboratories and Interventions, Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Keith L. March, MD, PhD is an Associate Professor of Medicine at the Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Myocardial gene therapy is an emerging therapeutic option for the treatment of patients with advanced ischemic heart disease. Early clinical experiences show feasibility and potential efficacy of gene-mediated therapeutic angiogenesis. As percutaneous methods of gene delivery mature, the interventional cardiologist will undoubtedly play a major role in the delivery of these agents and will require a working knowledge of this field. Future placebo-controlled, large, randomized trials with both current and new angiogenic factors will define the ultimate role of this therapy.
Patients with coronary artery disease refractory to medical therapy and without revascularization options continue to challenge the cardiologist. In recent years, myocardial gene therapy for the treatment of heart disease has evolved from bench to bedside. Early clinical trials of myocardial angiogenesis have shown promise 1 and emphasize the need for further studies to determine the optimal delivery method, agent, and dose for safe and effective therapy.
This review will focus on current aspects of catheter-based gene therapy for myocardial angiogenesis that are relevant to the interventional cardiologist, including possible delivery methods, agents, vectors, and potential problems with each strategy.
The prevalence of symptomatic patients with unrevascularizable end-stage coronary artery disease is increasing. Many of these patients remain symptomatic despite maximal anti-anginal therapy and may not be amenable to or may have failed surgical or percutaneous forms of myocardial revascularization. 2 It is estimated that approximately 12% of symptomatic patients with coronary disease undergoing cardiac catheterization are not candidates for percutaneous coronary intervention or coronary artery bypass grafting (CABG). These patients suffer high rates of cardiac events and have limited therapeutic options. 3 A potential therapeutic option for these patients is therapeutic angiogenesis.
Therapeutic angiogenesis is an intervention aimed at inducing neovascularization and promoting collateral formation in ischemic myocardium through the administration of angiogenic growth factors or their genes. 4 It is well known that coronary collateralization improves the prognosis of patients with obstructive coronary artery disease by limiting infarction size, preserving ventricular function, and enhancing overall perfusion in ischemic myocardium. 5,6 Thus, augmentation of collateral vessel growth may be a valuable approach in these patients.
Angiogenesis is a process in which new capillaries sprout from the existing vasculature by way of proliferation and migration of endothelial cells. This is mediated, in part, by angiogenic growth factors. 1,7 Wound healing and reproductive growth are examples of physiologically normal forms of angiogenesis. Pathologic forms include tumors and diabetic retinopathy.
Angiogenesis can also be a response to ischemia. It is suggested that patients with extensive coronary disease may have an impaired endogenous angiogenic response, and enhancement of this process is the basis of therapeutic angiogenesis. 1
The feasibility of therapeutic myocardial angiogenesis was shown in initial animal studies, primarily using the angiogenic proteins, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). Early attempts to enhance collateral perfusion in ischemic myocardium used local administration of recombinant forms of these proteins. 8 These studies showed the efficacy of exogenous supplementation of growth factors by demonstrating enhancement of collateral flow as well as improvement in myocardial perfusion and in wall motion. 9-11
Administration of recombinant proteins for angiogenesis has shown benefits in several phase I trials. 12 However, there are several limitations to protein delivery methods. A critical problem is inadequate myocardial exposure time due to brief serum and tissue half-life of the protein. Higher initial concentrations and multiple administrations of the angiogen would provide efficacy, but at the expense of potential side effects. 7 In contrast, gene therapy modalities offer a sustained, but self-limited, expression of therapeutic factors that can achieve desired biological effects in a single dose. 1
The goal of cardiac gene therapy is to deliver genetic material (frequently by plasmid or viral vectors) to the myocardium in order to induce sustained and local overexpression of the transgene. This process is called transfection. 13 The degree of physiologic effect derived from gene transfer is dependent on the efficiency of the transfection process. Because of variable transfection efficiencies, gene therapy has a more unpredictable dose-response relationship in comparison with protein methods. 7
Successful gene therapy is contingent on several consecutive steps (Figure 1): (1) the method of gene delivery to the target tissue, (2) a capable vector system allowing intracellular passage of genetic material (plasmid or virus), and (3) robust local expression of an appropriate transfected gene (angiogenic agent) within the target tissue. 13
Various routes of administration have been used in delivering angiogenic proteins and genes. 8 The optimal technique maximizing safety and efficacy for myocardial gene delivery is not well established.
An ideal technique would deliver angiogenic factors in a site-specific manner to the target tissue, minimizing systemic exposure. It should achieve high local concentrations as well as provide sufficient tissue retention time to allow cell interaction and subsequent gene transfer. 12 Finally, the technique should be simple to perform, relatively inexpensive, and use existing technologies.
Catheter-based myocardial delivery can be divided into three methods: intravascular, intramyocardial, and intrapericardial.
Intravascular approaches
Intravenous (IV)-- Intravenous administration is the simplest form of delivery. Its major drawback, however, is very low myocardial tissue uptake. In radiolabeled distribution studies, only 0.26% of bFGF was isolated in ischemic myocardium 1 hour after IV injection and 0.04% after 24 hours. 14 This results in significant systemic exposure of the agent, consequently increasing the risk for side effects. Accordingly, IV administration of agents will not be effective in inducing angiogenesis. 7
Intravenous administration of an agent that is designed with a "homing" mechanism can improve myocardial delivery. This has been performed by complexing therapeutic agents with ultrasound contrast bubbles that can be injected intravenously and subsequently lysed at the myocardium with transthoracic high-frequency ultrasound. 15
Intracoronary -- The intracoronary route has been used in many clinical trials of angiogenesis. 1,16-18 It is favored because it is relatively simple to administer in the catheterization laboratory, requires no special equipment, is widely available, and is suited to most patients with coronary disease. 7 The intracoronary route is limited by poor myocardial tissue uptake, although it is slightly better than the IV route. Approximately 3% to 5% of bFGF was recovered from the myocardium several hours after intracoronary injection, and with a low 0.04% retention after 24 hours. 16 In a phase I study, patients receiving selective intracoronary injections of FGF-2 incurred similar systemic exposures to those receiving IV infusions. 16 Despite relatively poor first-pass uptake, animal studies and phase I studies seemed to indicate potential efficacy of single bolus intracoronary protein injections. 1,10,11
Coronary venous retroinfusion-- Coronary venous retroinfusion is gaining interest as an efficient myocardial gene-delivery modality. Retroinfusion into the coronary vein is very effective in delivering drugs to the myocardium and microvascular bed. 19 Deposition is enhanced significantly in ischemic myocardium during balloon occlusion of a corresponding coronary artery. Significantly longer tissue retention has also been reported by this route. 20
This method is performed by cannulation of a selected cardiac vein via the coronary sinus using a modified balloon-tipped perfusion catheter. The coronary vein is then occluded to prevent drainage. Pressure-regulated infusion of the gene agent is performed at an internal venous pressure of 20 mm Hg for several minutes. 20 Another modification of this technique is selective high pressure (100 mm Hg) single-bolus injection (10 mL). The technique appears to be safe because no echocardiographic evidence of myocardial dysfunction has been noted, and myocardial marker release is minimal. 21
Gene delivery with this method has been shown to be feasible. Pressurized retrograde coronary venous delivery of an adenovirus has shown considerably more gene expression than that of antegrade intracoronary administration in pigs. 20 The technique is also effective for plasmid-driven angiogenesis as well. Administration of plasmid developmental endothelial locus-1 (del-1, an angiogenic factor) improved myocardial perfusion in ischemic pigs. 22 In addition to gene delivery, coronary venous retroinfusion provides widespread distribution of cells and microspheres to the myocardial interstitium. 23
Intramyocardial approaches
Until recently, all myocardial gene delivery methods were surgical in nature. Early phase I clinical trials of gene-based myocardial angiogenesis administered growth factors by direct transepicardial injection at the time of CABG or using minithoracotomy. 1,7 This approach was favored over intravascular methods due to the lack of significant myocardial washout and dissemination to distant tissues after initial injection. 8 Subsequent animal studies have shown, however, that incomplete retention of injectate also occurs with intramyocardial delivery, although to a lesser degree. 24
Transendocardial intramyocardial-- Currently, the only clinically feasible catheter-based method of intramyocardial administration is transendocardial intramyocardial delivery via an intracavitary left ventricular approach. This technique has been validated in preclinical and clinical studies. 25 In a biodistribution study comparing epicardial open chest injection of microspheres with percutaneous endomyocardial delivery in pigs, the endomyocardial tissue retention was better (43% versus 15%) than thoracotomy-based epicardial injection. 24
Transendocardial injections are performed with various specialized catheters that have retractable sheathed needles 25 or helical infusion needles. 26 The catheter is advanced intra-arterially across the aortic valve into the left ventricle and endocardial injections are performed. There are several adaptations to this technique, using different guidance methods such as intracardiac echocardiography (ICE), 27 fluoroscopy, 28 and electromechanical mapping. 25,29 The only published clinical experience to date is with electromechanical guidance. 25,29
Fluoroscopic-guided endocardial gene transfer alone is not likely to be useful clinically because it does not provide adequate anatomic information about injection sites or the nature of the myocardium. However, ICE guidance in conjunction with fluoroscopy provides useful information, such as directing needle position and monitoring systemic leakage of gene injectate, and it provides the ability to see injected sites to avoid repeat administration. 27
Transendocardial injection guided by a left ventricular electromechanical mapping system (NOGA, Biosense Webster, Inc.; Diamond Bar, CA) has gained considerable interest. Using a magnetic field, the system is able to precisely locate the catheter in the ventricle in three dimensions. In addition, electromechanical mapping can delineate normal, ischemic, or hibernating myocardium based on the amplitude of unipolar endocardial potentials and assessment of local myocardial cell shortenening. 25,29
Disadvantages of this technique include the requirement of multiple injection sites, relatively small injection volumes (0.1 to 1 mL), and a relatively complex mapping method.
Intrapericardial approach
Another catheter-based method that provides efficient gene transfer is intrapericardial administration. Catheters have been developed to access the pericardial space percutaneously in a safe manner in animals. 30 A helical-tipped transventricular penetrating catheter has been used to instill various genes into the pericardial sac of dogs. Under fluoroscopic guidance, the catheter is advanced into the right ventricle, and the tip is passed through the apex. Alternatively, a percutaneous transthoracic catheter incorporates a sheathed needle with a suction device to grasp the pericardium and access the pericardial space.
Robust gene expression has been seen in the pericardium and epicardium with these techniques, while serum and distant tissue levels were undetectable or at background levels. 31 Minimal systemic exposure, high transgene expression from adenoviral vectors, and potentially widespread myocardial delivery are valuable characteristics. However, the clinical use of this technique may be limited because of prior pericardial manipulation in many patients with cardiac surgery. 8 Furthermore, assessment of theoretical risks such as intrapericardial bleeding with angiogenesis therapy needs further study. 13
Cardiovascular gene transfer requires effective and durable vectors that carry and facilitate entry of genetic material into the target cell and to the nucleus. 13 Once this is accomplished, sustained expression of the transgene can occur. The vector usually contains a promoter region that allows for expression and translation of the gene, a copy DNA segment encoding the angiogenic factor, and various signals for ending translation and for posttranslational processing. 32 The traditional types of vectors used for gene therapy are nonviral and viral.
Nonviral gene transfer
Nonviral plasmid-mediated DNA transfer is used because of its safety profile and transient expression. Many viral vectors produce an immune response to some degree, which is avoided with nonviral methods. In addition, transient transgene expression occurs in the nucleus without incorporation into chromosomal DNA. 13 Plasmids can also incorporate larger cassettes to code multiple genes or larger proteins. A major disadvantage, however, is that naked DNA has a short half-life due to degradation by circulating nucleases and scavenger receptors. 33 Plasmids are also very inefficient in transfection. 34
The formulation of plasmid DNA complexes with macromolecules has enhanced stability and transfection. 34 The DNA is combined with polymers, such as cationic liposomes or poloxamers. Negatively charged DNA combines with positively charged cationic lipids that form stable structures, which isolate plasmids from nucleases and facilitate entry into the cell by endocytosis. 34
Another novel way to enhance and target nonviral DNA delivery is with the use of microbubbles. Plasmid DNA is complexed with microbubbles, delivered to the myocardial circulation, and subsequently disrupted with high-power ultrasound releasing the genetic material to the target area. It is based on contrast microbubbles similar to those used in contrast echocardiography and can be formulated of albumin, polymeric shells, or cationic lipid membranes. 15 In a porcine study of systemically delivered plasmid DNA, transfection occurred only in myocardium that was exposed to the ultrasound beam. 35 Similarly, a 10-fold increase in transfection efficiency was noted with an adenovirus formulated with microbubbles. There was, however, extensive transgene expression in the livers of all animals in which this method was used, 17 suggesting that site-specific delivery may still be necessary.
Viral gene transfer
Gene transfer with the use of engineered viruses is very efficient in transfecting cells. This is primarily due to the innate ability of a virus to infect a cell and transfer its genetic material. Viruses are not subject to intravascular degradation in contrast to plasmids. Several different types of viruses can be used for gene therapy. The concerns of viral gene therapy are of host immune responses and prolonged gene expression leading to overexposure to the angiogenic factor. 36
Adenoviruses have been studied extensively and provide short-term, 1- to 2-week, transgene expression without integrating into host DNA. They are capable of transfecting both the proliferating and nonproliferating cells. These viruses are rendered replication-deficient, and the genome is replaced with the desired angiogenic expression cassette. 13 Newer generation adenoviruses have a longer duration of expression and less immunogenicity. Adeno-associated viruses provide longer duration of expression as well. 1 Retroviral vectors transfer RNA, which is transcribed to DNA and integrated into the host genome resulting in long-term expression. Retroviruses have limited use in the myocardium, as they can only transfect proliferating cells. 32
Many angiogenic growth factors have been identified (Table 1). 12,37 However, all clinical trials of angiogenesis to date have studied the VEGF and FGF classes. 12 Human cardiovascular gene therapy trials in progress or in early development are now expanding to trials using platelet-derived growth factor, hypoxia inducible growth factor-1*, del-1, and nitric oxide synthase. 37
Vascular endothelial growth factor is an endothelial cell-specific mitogen and exerts its influence by means of specific receptors. 1 There are several isoforms of the VEGF protein and all isoforms impart angiogenic effects. 32 However, of the several receptors for VEGF, only the VEGFR-2 (KDR) receptor mediates angiogenesis.
Fibroblast growth factors are a family of several angiogens that share a similar protein structure. In contrast to VEGF, their effects include proliferation of multiple cell types including endothelial cells, smooth muscle cells, and fibroblasts. 38 Both VEGF and FGF can enhance production of various proteases essential to matrix degradation for angiogenesis. 32,38
Despite the promise seen in both preclinical and early clinical gene transfer studies, concerns regarding safety of gene delivery and toxicity of therapy have arisen. The death of a patient in a phase I gene therapy trial for treatment of ornithine transcarbamylase deficiency due to an adenovirus-mediated reaction has triggered concern. 36 Adenoviral vectors are known to induce inflammatory and immunologic reactions that are sometimes severe. Furthermore, VEGF trials have reported hypotension, edema, and formation of spider angiomas. 1,39 In some cases, overexpression of VEGF has produced vascular tumors, vessel clusters, and severe localized edema. 1 Similarly, FGF has shown potential toxicities including hypotension, proteinuria, and thrombocytopenia. 13,16
The risk of pathologic angiogenesis is also of concern due to the possibility of enhanced growth of clinically silent malignancies. Retinal neovascularization (diabetic retinopathy and retinal vasculopathies) is associated with elevated levels of VEGF. 12
Initial catheter-based phase I clinical studies administered recombinant protein by the intracoronary route. These studies were small and without placebo controls, but did show potential benefit including improvements in exercise duration, perfusion, and fewer anginal symptoms. 1 Larger phase II placebo-controlled clinical studies with the same approach, however, did not yield the same results. Patients treated with intracoronary and IV VEGF in the VEGF in Ischemia for Vascular Angiogenesis Trial failed to meet endpoints of improved exercise time and angina class. 18 In the FGF-2 Initiating Revascularization Support Trial, intracoronary injection of FGF-2 did not improve exercise time or improve perfusion. 1 These findings are not surprising given the unfavorable pharmacokinetics of intracoronary delivery described previously.
To date, there are three published clinical trials of catheter-based gene transfer for angiogenesis (Table 2). 17,25,29 These trials evolved from the need for a placebo control arm. Early phase I gene trials used intraoperative direct myocardial injection for gene transfer that precluded randomization to placebo due to the inherent risks of surgery and anesthesia. 17 Percutaneous methods allowed a control arm to the study design.
The first percutaneous trial of catheter-based gene therapy was a pilot study to show the safety and feasibility of transendocardial gene transfer using left ventricular electromechanical mapping. Vale and colleagues 25 randomized 6 patients to plasmid VEGF-2 gene transfer or a placebo procedure. Improvements in anginal episodes and nitroglycerin use were noted in both groups, though the placebo group later experienced worsening angina, whereas the patients in the gene transfer group continued to improve. Perfusion scores and electromechanical function in ischemic sites were significantly better in the VEGF-treatment group than in the placebo group.
Based on these initial findings, a phase II dose-escalation study of 19 patients using the same method was performed and significant improvements were found in the Canadian Cardiovascular Society anginal class (3.5 versus 2.2, P = 0.012) and a significant mean change in angina class for patients treated with plasmid VEGF-2 (1.2 versus 0.1, P = 0.04). There were trends toward improvements in exercise duration, angina questionnaire data, and perfusion on single-photon emission tomography. 29
Finally, in the Angiogenic GENe Therapy Trial, a phase II, double-blinded, randomized, placebo-controlled trial of 79 patients showed safety of intracoronary adenoviral gene transfer of FGF-4. Treated patients showed a nonsignificant increase in exercise duration at 4 weeks (1.3 versus 0.7 min, P = not significant). However, in a subgroup analysis of patients excluded with exercise times >10 minutes, this difference became significant (1.6 versus 0.6 min, P = 0.01). 17
It is important to note the limitations of these and other trials of gene therapy. The studies are relatively small, and many are nonrandomized or uncontrolled. Furthermore, endpoints such as exercise duration and health status measures are "soft" endpoints and can be subjective. 7 These issues underscore the need for larger phase II, randomized, placebo-controlled trials to definitively prove efficacy.
The application of percutaneous catheter-based gene therapy techniques will allow larger scale studies to be performed. These same techniques may apply to other emerging technologies (such as cell delivery/transplantation for myocardial regeneration), thus continuing to expand the role of interventional cardiologists.


text:
Paan without tobacco: An independent risk factor for oral cancer (HTML)
Merchant,Anwar; Husain,Syed S.M.; Hosain,Mervyn; Fikree,Fariyal F.; Pitiphat,Waranuch; Siddiqui,Amna Rehana; Hayder,Syed J.; Haider,Syed M.; Ikram,Mubashir; Chuang,Sung-Kiang; Saeed,Shaikh A.
International Journal of Cancer 86(1): 128-131
Publication date: 2000
Oral cancer is the second most common cancer in women and the third most common in men in Pakistan. Tobacco is smoked and chewed extensively in Pakistan. Paan is a quid of piper betel leaf that contains areca nut, lime, condiment, sweeteners, and sometimes tobacco, which is also used extensively. We did this study to clarify the independent association of paan and oral cancer. Between July 1996 and March 1998, we recruited biopsy-proven, primary cases of oral squamous-cell carcinoma, from 3 tertiary teaching centers in Karachi, Pakistan, and controls pair-matched for age, gender, hospital and time of occurrence, excluding persons with a past or present history of any malignancy. There were 79 cases and 149 controls. Approximately 68% of the cases were men, 49 years old on average, the youngest being 22 years old and the eldest 80. People with oral submucous fibrosis were 19.1 times more likely to develop oral cancer than those without it, after adjusting for other risk factors. People using paan without tobacco were 9.9 times, those using paan with tobacco 8.4 times, more likely to develop oral cancer as compared with non-users, after adjustment for other co-variates. This study identifies an independent effect of paan without tobacco in the causation of oral cancer. Its findings may be of significance in South Asian communities where paan is used, and among health-care providers who treat persons from South Asia.
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Lunch Box Notes For Kids Sweeten Lil Ones' Lunch Boxes With a Love Note From Mom by Rebecca M Gruber 8/07/13 76 Reactions 959 Shares Print 662 267 27 3 0 The lil taste of home that mama packed for lunch tastes much sweeter when tots know it was packed with love. Back to school means back to lunch-making for many moms. When packing tasty sandwiches and snacks consider throwing in a tiny note showing your lil scholar that you're thinking of him throughout the day. We know moms are too busy to write out meaningful notes each and every morning, so we've rounded up eight lunch note options that keep it simple and sweet during the morning rush. Happy lunch-making! Start Peagreen Mini Lunch Notes What's Your Reaction? 0 0 0 0 0 0 Keep this handy box of Mini Lunch Notes and stickers ($10) right next to the sandwich-making station at home, and lil ones will always feel Mama's love when they open up their lunch box. 1 / 12 Lunch Note Jokes What's Your Reaction? 0 0 0 0 0 0 Peonies and Poppyseeds has a printable set of lunch note jokes (free) that will put a smile on kids' faces. 2 / 12 Lauren McKinsey Designs Lunch Box Notes What's Your Reaction? 0 0 0 0 0 0 Keep the printer humming because Mama's going to want to print several sets of these! Lauren McKinsey Designs's Lunch Box Notes ($6) are sent to buyers as a PDF file that can be printed right at home. Available in both boy and girl styles, they come with 10 fun cards that will put a smile on tots' faces in the middle of the day! 3 / 12 Printable Lunchbox Notes, Tags, and Stickers What's Your Reaction? 0 0 0 0 0 0 Alphamom's printable lunchbox notes, tags, and stickers (free) are almost too cute to be thrown away. They not only encourage tots to eat their fruit, but they're simply sweet as well! 4 / 12 Frog Paper Prince Lunch Box Love Notes What's Your Reaction? 0 0 0 0 0 0 Make that first day back to school even more special with a cute note from Mom. Frog Paper Prince has designed a downloadable set of four lunch note designs (free) that tuck perfectly into their midday meal. 6 / 12 Printable School Lunch Jokes What's Your Reaction? 0 0 0 0 0 0 Help put a smile on their face in the lunch room with All For the Boys' printable school lunch jokes (free). The set of eight joke cards are the perfect lunchtime humor for the under-10 set and will keep your kids' dining companions laughing well into their next activity. 6 / 12 Free Printable School Lunch Box Notes What's Your Reaction? 0 0 0 0 0 0 Chickabug's Printable School Lunch Box Notes (free) are a sweet addition to the lunch box with their positive and uplifting messages for kids. 7 / 12 Magic Message Bananas What's Your Reaction? 0 0 0 0 0 0 Bananas are a staple in many kids' lunches, but did you ever think about including a secret message on the peel? At Come Together Kids, Laura offers a tutorial for pin-pricking messages on the peels (free) that show up by the time the kiddos eat. 8 / 12 Oliebollen Lunch ID Tags What's Your Reaction? 0 0 0 0 0 0 Whether these are used to put lil one's name on their bags, or placed inside their lunch bags as a note, Oliebollen's free Lunch ID Tags (free) are a fun way to show tots that Mom's thinking about them throughout the day. 9 / 12 Lunch Box Notes What's Your Reaction? 0 0 0 0 0 0 This set of 16 lunch box note cards ($8) celebrate little milestones throughout the school year. 11 / 12 The Official Lunch Survey What's Your Reaction? 0 0 0 0 0 0 Getting lil ones to talk about their day can be torture. They just don't want to open up. With June Pfaff Daley's Official Lunch Survey (free) kids fill out information about how their day is going, what they think about lunch, and what they would like to do after school, so it's both productive and entertaining! 11 / 12 Lunch Box Notes What's Your Reaction? 0 0 0 0 0 0 This set of scratch-off lunch box notes ($15) is full of mystery and fun! 12 / 12 662 267 27 3 0 Back to Homepage Read More First Day Of SchoolLunch BoxNotecardsLunch Box IdeasBack To School What's Your Reaction? 0 0 0 0 0 0 0Reactions megan1364785526 29 weeks Gives both mom and kiddo the warm fuzzys. inklings 30 weeks Er... now I feel silly! My lunchbox notes are actually depicted in this article (slide 15). Rebecca, thanks so much for the feature!! inklings 30 weeks Cute ideas! @corcar86, I agree with you on the power of a handwritten note. They're so much more personal! I'm a mom and lover of all things paper, and I've made these little DIY scratch-off lunchbox notes for my son that I now sell on Etsy. They're great for back to school, and are so much fun for kids to scratch and see your secret message in their lunch: https://www.etsy.com/listing/158492110/20-scratch-off-lunchbox-notes-mini?ref=shop_home_active ahadden 1 year Hello, I post free printable lunch notes every school morning on my site http://littlelunchnotes.com/. Jokes, fun facts, etc - please take a look. awesomepants 2 years How cool! My siblings and I lived right across the street from school so we always went home for lunch and watched the Price Is Right. corcar86 2 years My mom would often surprise us with a little not in our lunchboxes sometimes accompanied by a little toy or treat to make it extra special or even a note or doodles all down the side of a brown paper lunch bag and it was awesome. Somehow I think a little of the charm is gone with some of these notes...especially the ones with "It's ____ and you are awesome" I feel like taking 2 seconds to write something in your own handwriting is much better. The ones that are just blank fun tags and stuff are cute but the ones that already bare messages just seem lazy and impersonal especially to give a child but that's just my opinion...wonder what others thought?? Link Love Mom forced to stop feeding baby homemade formula — BabyCenter Blog The easiest ways to save on organic food — The Stir A look inside Fergie's second baby shower — Celebrity Baby Scoop Danielle Jonas debuts her baby bump — People Moms & Babies 7 light and fresh recipes to take you through Summer — FitPregnancy Does where you live affect your risk for PPD? — The Bump Where to find the best deals on school supplies — Real Simple Now this is how you announce a pregnancy! — HuffPost Parents
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Found November 13, 2012 on
It's déjà vu all over again for Chicago Bears fans in 2012. The Chicago Bears went on a long winning streak which had people talking about them as a top team in the NFL, just like last season. Now Jay Cutler is hurt, just like last season. The question now is whether or not Cutler will miss extended time, and how Jason Campbell will perform in his absence.
It could be seen as a positive for the Chicago Bears that they only lost by seven points on Sunday to a Houston Texans team that many consider to be the best team in the NFL. Add in the fact that Chicago lost Cutler at the half and Sunday's loss could be seen as downright encouraging. But there is more to consider before Bears fans get too excited.
The Chicago Bears have yet to prove over the past few years that they can win any games without Jay Cutler. 2010 NFC championship game, Cutler goes down and the Bears lose. 2011 regular season, Cutler goes down and the Bears plummet from playoff contention. The Bears needed a ch...
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Jay Cutler is concussed and will miss the second half against the Texans; but the diagnosis comes late
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Jay Cutler concussed on vicious hit by Texans LB
Cutler's status remains up in air
NFL's focus protocol, not safety
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The Effects of Solutes on the Freezing Properties of and Hydration Forces in Lipid Lamellar Phases Biophysical Journal, Volume 74, Issue 4, 1 April 1998, Pages 1949-1965 Yong Hyeon Yoon, James M. Pope and Joe Wolfe Abstract Quantitative deuterium nuclear magnetic resonance is used to study the freezing behavior of the water in phosphatidylcholine lamellar phases, and the effect upon it of dimethylsulfoxide (DMSO), sorbitol, sucrose, and trehalose. When sufficient solute is present, an isotropic phase of concentrated aqueous solution may coexist with the lamellar phase at freezing temperatures. We determine the composition of both unfrozen phases as a function of temperature by using the intensity of the calibrated free induction decay signal (FID). The presence of DMSO or sorbitol increases the hydration of the lamellar phase at all freezing temperatures studied, and the size of the increase in hydration is comparable to that expected from their purely osmotic effect. Sucrose and trehalose increase the hydration of the lamellar phase, but, at concentrations of several molal, the increase is less than that which their purely osmotic effect would be expected to produce. A possible explanation is that very high volume fractions of sucrose and trehalose disrupt the water structure and thus reduce the repulsive hydration interaction between membranes. Because of their osmotic effect, all of the solutes studied reduced the intramembrane mechanical stresses produced in lamellar phases by freezing. Sucrose and trehalose at high concentrations produce a greater reduction than do the other solutes. Abstract | Full Text | PDF (287 kb) |
Breaking the Meyer-Overton Rule: Predicted Effects of Varying Stiffness and Interfacial Activity on the Intrinsic Potency of Anesthetics Biophysical Journal, Volume 80, Issue 5, 1 May 2001, Pages 2284-2297 Robert S. Cantor Abstract Exceptions to the Meyer-Overton rule are commonly cited as evidence against indirect, membrane-mediated mechanisms of general anesthesia. However, another interpretation is possible within the context of an indirect mechanism in which solubilization of an anesthetic in the membrane causes a redistribution of lateral pressures in the membrane, which in turn shifts the conformational equilibrium of membrane proteins such as ligand-gated ion channels. It is suggested that compounds of different stiffness and interfacial activity have different intrinsic potencies, i.e., they cause widely different redistributions of the pressure profile (and thus different effects on protein conformational equilibria) per unit concentration of the compound in the membrane. Calculations incorporating the greater stiffness of perfluoromethylenic chains and the large interfacial attraction of hydroxyl groups predict the higher intrinsic potency of short alkanols than alkanes, the cutoffs in potency of alkanes and alkanols and the much shorter cutoffs for their perfluorinated analogues. Both effects, increased stiffness and interfacial activity, are present in unsaturated hydrocarbon solutes, and the intrinsic potencies are predicted to depend on the magnitude of both effects and on the number and locations of multiple bonds within the molecule. Most importantly, the intrinsic potencies of polymeric alkanols with regularly spaced hydroxyl groups are predicted to rise with increasing chain length, without cutoff; such molecules should serve to distinguish unambiguously between indirect mechanisms and direct binding mechanisms of anesthesia. Abstract | Full Text | PDF (271 kb) |
Preferential Hydration of DNA: The Magnitude and Distance Dependence of Alcohol and Polyol Interactions Biophysical Journal, Volume 91, Issue 3, 1 August 2006, Pages 912-920 Christopher Stanley and Donald C. Rau Abstract The physical forces that underlie the exclusion of solutes from macromolecular surfaces can be probed in a similar way as the measurement of forces between macromolecules in condensed arrays using the osmotic stress technique and x-ray scattering. We report here the dependence of alcohol exclusion or, equivalently, the preferential hydration of DNA on the spacing between helices in condensed arrays. The actual forces describing exclusion are quite different from the commonly assumed steric crowding coupled with weak binding. For a set of 12 nonpolar alcohols, exclusion is due to repulsive hydration interactions with the charged DNA surface. Exclusion amplitudes do not depend simply on size, but rather on the balance between alkyl carbons and hydroxyl oxygens. Polyols are included at very close spacings. The distance dependence of polyol inclusion, however, is quite different from nonpolar alcohol exclusion, suggesting the underlying mechanism of interaction is different. Abstract | Full Text | PDF (213 kb) |
Copyright © 2008 The Biophysical Society All rights reserved.
Biophysical Journal, Volume 94, Issue 7, 2777-2789, 1 April 2008
Christopher Stanley*, †, , , Susan Krueger*, V. Adrian Parsegian† and Donald C. Rau†
* NIST Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, Maryland
† Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
Interactions governing protein folding, stability, recognition, and activity are mediated by hydration. Here, we use small-angle neutron scattering coupled with osmotic stress to investigate the hydration of two proteins, lysozyme and guanylate kinase (GK), in the presence of solutes. By taking advantage of the neutron contrast variation that occurs upon addition of these solutes, the number of protein-associated (solute-excluded) water molecules can be estimated from changes in both the zero-angle scattering intensity and the radius of gyration. Poly(ethylene glycol) exclusion varies with molecular weight. This sensitivity can be exploited to probe structural features such as the large internal GK cavity. For GK, small-angle neutron scattering is complemented by isothermal titration calorimetry with osmotic stress to also measure hydration changes accompanying ligand binding. These results provide a framework for studying other biomolecular systems and assemblies using neutron scattering together with osmotic stress.


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Little feet are free to stride without missing a step in these cool kicks. High-quality leather provides a comforting feel, and the lightweight rubber sole keeps feet in step and on track.
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text: BIG BROTHERS BIG SISTERS OF LONG ISLAND SELECTED AS THE OFFICIAL CHARITY PARTNER FOR THE RUN OR DYE 5K RUN AT NASSAU COLISEUM Big Brothers Big Sisters of Long Island is proud to announce that it has been selected as the Official Charity Partner for the Run or Dye 5K run on April 12, 2014 at Nassau Coliseum. Run or Dye is the world's most colorful 5K fun run where participants are showered in safe, eco-friendly, plant-based cornstarch dye at every kilometer. "Run or Dye has a great relationship with other Big Brothers Big Sisters agencies across America and we are excited to be a part of this incredible event when it comes to Long Island in April," said Chris Cosentino, BBBSLI Director of Marketing & PR. "We are very thankful for the support we have received from Run or Dye and this event promises to be an awesome experience for everyone involved." As the Official Charity Partner, BBBSLI will receive a generous financial contribution for every volunteer that registers for the event using the special Non-Profit Reference ID: BBBSLI. Volunteers will receive gifts and other incentives throughout the event. How to sign up as a volunteer and support BBBSLI: 1). Go to www.runordye.com/volunteer 2). Complete the online form and scroll to the Long Island event location 3). Enter Non-Profit Reference ID: BBBSLI Run or Dye representatives will be in constant contact with all volunteers prior to the event. If you have any questions, please feel free to call 516.731.7880 x222 or email email@example.com. BIG BROTHERS BIG SISTERS OF LONG ISLAND CELEBRATES NATIONAL MENTORING MONTH AT 2014 WINTER BLAST As part of its on-going professional support of mentoring matches, Big Brothers Big Sisters of Long Island coordinates match activities throughout the year. In celebration of National Mentoring Month, on Saturday, January 25th, BBBSLI hosted the 2014 Winter Blast & Book Fair sponsored by Target. "Thank you to Target for sponsoring this wonderful event," said BBBSLI CEO Mark Cox. "After seeing the enjoyment on the faces of everyone in attendance, it was the perfect way for us to celebrate National Mentoring Month." Two hundred Bigs and Littles enjoyed a fun-filled afternoon at Dave & Buster's in Farmingdale. Every Little Brother and Little Sister in attendance walked away with new a backpack full of books. |


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2012 bmw m5 ring taxi
There's any number of cars that can be used for taxis. The Ford Crown Vic, Nissan NV, Toyota Sienna... pretty much anything with a useable back seat, a cargo area and a roof on which to put a dome light. But a BMW M5? Surely that has to be overkill, right? Maybe for most taxis, but this is no ...


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COLUMBIA — Same-sex domestic partners of University of Missouri System employees have the backing of the MU Faculty Council in receiving the same benefits opposite-sex spouses currently get.
Resolution approved for same-sex domestic partner benefits at MU
Thursday, March 4, 2010 | 6:55 p.m. CST;
updated 3:49 p.m. CST, Friday, March 5, 2010
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Babies grow up fast, and families are often stuck with lots of unwanted but perfectly good gear. That's why Marnie Owens and two friends started Baby2Baby, an organization that distributes new and gently used baby clothing and equipment to needy families living in the Los Angeles area. The Peetes talk with Marnie about Baby2Baby's mission and how others can get involved.
Marnie says Baby2Baby works to fulfill the requests of 12 Los Angeles organizations dealing with homelessness, domestic violence, teen pregnancy and family preservation. The charitable organizations are all in need of supplies, ranging from cribs and strollers to toys and clothing. "In Los Angeles, there's obviously the haves and the haves not, and there's a great excess of baby gear," she says. "Why not recycle it and put it in the hands of families that need it?" While Marnie says Baby2Baby has received widespread support for its work, it is currently unable to provide assistance to mothers outside of Los Angeles. She encourages others to become active in their own communities and see what a big difference they can make. "We're three women who had an idea, and we just decided, 'Hey, let's go for it, let's try it,' and it's worked, it's taking off," Marnie says. "So we encourage people to do it. It's a lot of work, but it's not as hard as you think, and it's very satisfying." |


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University of Oslo e-mail: frank at ifi.uio.no Department of Informatics Phone :+47 22 84 01 48 P.O.Box 1080 Blindern Fax :+47 22 85 24 01 N-0316 Oslo http://www.ifi.uio.no/~frank/
I am member and group leader (currently on leave) of the research group Networks and Distributed Systems
I am also affiliated to Simula Research Laboratory
NEW: Slides (pdf) on available master thesis topics.
NEW: Recent paper on the MUSIC middleware (preprint).
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Howler Brothers Longsleeve Aransas Shirt (discontinued colors)
Product Description
By popular demand, we now make our super popular Aransas Shirt with long sleeves. Like its short-sleeved older bro, the Longsleeve Aransas is made of quick drying poly-cotton and features two button through pockets along with the Howler original sunglass cleaning pocket at left chest. We have also added our subtle vented back yoke to the list of features. Details include contrast stitching and embroidered monkey icon at back center yoke. Straight hem hits just below the waist. Available in Foursqaure Plaid: Firehole, Dolphin Blue Microcheck, and Sandstorm Microcheck.
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Howler Brothers Pescador Longsleeve Shirt (discontinued colors)Regular Price: $85.00 Special Price: $65.00 |
Howler Brothers Loggerhead Longsleeve ShirtRegular Price: $65.00 Special Price: $50.00 |


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Southern California's Blues Magazine Since 1990
to the official Southland Blues Magazine web site.
Published 12 times per year since 1990, SBM features artist profiles, CD, video and live reviews as well as club and festival calendars, radio listings, and columns with reports covering the Los Angeles, Orange County, and greater Southern California Blues scene.
Pete Sardon wishes that our readers could have heard the interview with Catfish as his enthusiasm and passion for the blues was so resonant aurally. Learn about his blues influences and where you can catch him and his vibrant band.
Southland Blues Magazine is honored to be the
2004 "Keeping the Blues Alive" Award Recipient for Print Media
click HERE for press release


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Just Go With It just barely bested Justin Bieber: Never Say Never at this weekend's box office.
The Adam Sandler/Jennifer Aniston comedy brought in $31 million, leading the way and besting Bieber's film, which brought in $30.3 million, according to Variety.
Third place went to Gnomeo and Juliet, which had a solid start with $25.5 million in ticket sales.
Variety notes that Ed Helms' Cedar Rapids also had a good start to its box office run, with $310,789 in ticket sales from 15 locations.
source: JustJared.com


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- Developing in Ext GWT is a fast-paced, practical guide to quickly learning the tasks necessary in building enterprise-class rich Internet applications.
Decompiling Android looks at the the reason why Android apps can be decompiled to recover their source code, what it means to Android developers and how you can protect your code from prying eyes. This is also a good way to see how good and bad Android apps are constructed and how to learn from them in building your own apps.
Cracking iPhone and Android Native Development
You've developed a killer app for one mobile devicenow it's time to maximize your intellectual investment. With Cracking iPhone and Android Native Development, you'll learn how to quickly retool your app for the full spectrum of mobile platforms and devices. -
Beginning Java Google App Engine
If you are a Java programmer, this book offers you a Java approach to beginning Google App Engine. You will explore the runtime environment, front-end technologies like Google Web Toolkit, and the datastore behind App Engine. You'll also explore Java support on App Engine from end to end.
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Beginning Google Sketchup for 3D Printing
Beginning Google SketchUp for 3D Printing is an easy-to-use guide to the generation of Google Sketchup designs for the 3D printing process. This book helps the reader navigate the maze of the 3D design and 3D printing process from start to finish.
Beginning Google Maps Mashups with Mapplets, KML, and GeoRSS
Beginning Google Maps Mashups with Mapplets, KML, and GeoRSS is a beginner's guide to creating web mashups using Google mapping technology. This book is a single-source primer to displaying data on Google Maps and covers both Mapplets and the Google Maps API. It is everything you need to start participating in the geographic Web. -
Beginning Google Maps Applications with Rails and Ajax
Andre Lewis, Cameron Turner, Jeffrey Sambells, Michael Purvis
Beginning Google Maps Applications with Rails and Ajax: From Novice to Professional is the first book to comprehensively introduce the service from a developer perspective, showing you how you can integrate mapping features into your Rails-driven web applications.
Beginning Google Maps Applications with PHP and Ajax
Beginning Google Maps Applications with PHP and Ajax is the first book to comprehensively introduce Google's popular mapping API. This book shows you how to create practical, location-based applications that encourage users to interact with the service, add their own information, and dynamically mark up maps. -
Beginning Google Maps API 3 2nd Edition
This book is about the next generation of the Google Maps API. It will provide the reader with the skills and knowledge necessary to incorporate Google Maps version 3 on web pages in both desktop and mobile browsers.
- Beginning Google Blogger is a complete resource on how to create and manage a blog using Blogger. The book offers step-by-step instructions and visual aids which walk you through both the basics and advanced features of Blogger.
Beginning Android Web Apps Development
Beginning Android Web Application Development shows how to build applications using the key methods and techniques of Android development that you'll need to create your own dynamic, feature-rich Android mobile websites and applications.


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Mon June 11, 2012
ASNE names former Post-Dispatch editor as director
The former editor of the St. Louis Post-Dispatch is the new executive director of the American Society of News Editors.
The ASNE announced the hiring Monday of Arnie Robbins, who stepped down last month after 15 years at the newspaper, including more than six years as editor. He begins work with ASNE on July 9 as the organization moves to the University of Missouri campus in Columbia, from Washington.
Robbins succeeds Richard Karpel, who will remain in the Washington area and was recently named president and CEO of the Yoga Alliance, which represents and certifies yoga schools and instructors in the U.S.
ASNE announced in April it was partnering with the University of Missouri School of Journalism. It will continue to maintain an office in Washington.


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March 10, 2014
TORONTO -- Aaron Hill doubled home the go-ahead run in the
6th inning and Roy Halladay struck out nine as the Toronto Blue
Jays topped Texas 6-4.
It's the Blue Jays' sixth straight win at home.
Halladay improved to 12-and-5, giving up four runs and seven
hits in six-plus innings. Jamey Wright dropped to 3-and-4. Jeremy
Accardo finished for his 19th save in 23 chances.
The Rangers are 2-and-5 on their current nine-game road trip.


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It looks like Ericsson engineers took offense at Sprint's 4G claims - several engineers contacted us and gave us details about their 28Mbps 3.5G service. A couple of weeks ago, we ran a story in which we criticized Sprint for branding their WiMAX service as a 4G one. In our comments section, you could read the debate what is and what should not be considered as 4G. In Sprint's terms, WiMAX clearly qualifies for 4G, even though that "4G" moniker is the defined standard as Long Term Evolution or LTE - data and voice technology to be used in next-gen of cellphones and smart devices.
People inside Swedish technology giant Ericsson obviously took offense at Sprint's claims and we got contacted by several engineers, working in different departments of the company. It turns out that Ericsson started to deploy 3.5G equipment to the city of Milano, Italy. Using MIMO technology and HSPA protocol [High-Speed Packet Access], Ericsson plans to cover the city of fashion with up to 28Mbps [3.5 MB/s] downstream and 5.8 Mbps [828 KB/s] upstream Internet connectivity service. The company recently successfully tested 56Mbps [7MB/s] and should be able to upgrade firmware of its latest MIMO HSPA equipment in order to enable those speeds to.
When asked about "the real 4G" development, we received assurances that the announcements should be made soon. We would stay away from the conflict that obviously brews on engineering meetings. However, when we asked about pictures and screenshots of 4G LTE equipment or data transfers and similar backings to their claims, we received silence.
For now, Ericsson is deploying MIMO HSPA in Milano, Italy at the speeds of 28Mbps, potentially upgradeable to 56Mbps. Is that good enough? Only time will tell.
Thanks for reading BSN*


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Dining at SAMACorporate Membership
JOIN / RENEW NOWMembership contributions are tax deductible to the extent allowed by law, in the following amounts: Small Business ($450), Corporate Art Society Circle ($800 reduced rate; $2,300 full rate), Corporate Benefactor's Circle ($4,725), Corporate Leader's Circle ($9,475), Corporate Director's Circle ($24,200), Corporate Chairman's Circle* ($95,775 with rental; $98,775 without rental). *Complimentary rental of SAMA's facilities (valued at $3,000) affects the tax deductibility of the Chairman's Circle membership. Members may choose to decline any benefits that are non-tax deductible in order to receive a full tax deduction for their contribution.


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Sorry for the similar post, but I've now realised what the major problem is exactly; hoping somone else has had it:
I've got avchd mts files, recorded at 50p.
Premiere is seeing them as 25fps, plays the video back at half speed (its smooth - so they ARE obvioulsy 50p files).
Plays the audio back at normal speed so nothing syncs.
VLC plays them back correctly
codec: h264 - MPEG-4 AVC (part10) (h264)
Frame rate:50
Interesting erightsoft super shows frame rate of 25 as well.
Same error with mercury playback on or off. Updated QT.
Type | Name | Format | Binary | Version |
ICM | Microsoft RLE | MRLE | msrle32.dll | 6.1.7601.17514 |
ICM | Microsoft Video 1 | MSVC | msvidc32.dll | 6.1.7601.17514 |
ICM | Microsoft YUV | UYVY | msyuv.dll | 6.1.7601.17514 |
ICM | Intel IYUV codec | IYUV | iyuv_32.dll | 6.1.7601.17514 |
ICM | Helix I420 YUV Codec | I420 | i420vfw.dll | 184.108.40.206 |
ICM | Toshiba YUV Codec | Y411 | tsbyuv.dll | 6.1.7601.17514 |
ICM | Cinepak Codec by Radius | cvid | iccvid.dll | 220.127.116.11 |
ICM | ASUS ASV2 CODEC | ASV2 | asusasv2.dll | 184.108.40.206 |
ICM | Helix YV12 YUV Codec | YV12 | yv12vfw.dll | 184.108.40.206 |
DMO | Mpeg4s Decoder DMO | mp4s, MP4S, m4s2, M4S2, MP4V, mp4v, XVID, xvid, DIVX, DX50 | mp4sdecd.dll | 6.1.7600.16385 |
DMO | WMV Screen decoder DMO | MSS1, MSS2 | wmvsdecd.dll | 6.1.7601.17514 |
DMO | WMVideo Decoder DMO | WMV1, WMV2, WMV3, WMVA, WVC1, WMVP, WVP2 | wmvdecod.dll | 6.1.7601.17514 |
DMO | Mpeg43 Decoder DMO | mp43, MP43 | mp43decd.dll | 6.1.7600.16385 |
DMO | Mpeg4 Decoder DMO | MPG4, mpg4, mp42, MP42 | mpg4decd.dll | 6.1.7600.16385 |
is anyone willing to download a source file and see if they get the same thing? If I can show that its an issue with the source file then at least I can stop trying to "fix" my hardware/software.
Ppro CS5 win7 x64.
Will upgrade to cs6 today if that will fix it!
heres a small sync test vid straight from camera
What camera shot the footage? My Sony NX5U AVCHD files use CABAC encoding and don't inject text into the file. According to MediaInfo, your camera didn't use CABAC and there is text injected into the file. MediaInfo also reports the frame rate as 25 fps.
No matter what I try, the file you uploaded won't play back properly in CS5.5. Not in the Source Monitor, not in a matching 25 fps sequence, not as a re-interpreted 50 fps subclip and not as the original 25 fps clip in a 50 fps sequence. I get dropped frames and random frames from other parts of the clip. My NX5U clips have *never* behaved that way.
Hi Jeff thanks so much for taking the time to try it out.
the camera is GH2, bought second hand recently, I just checked the firmware and it was running original firmware when I shot the clips. I'm going to hack it to see if that helps, but in the meantime i've still got lots of stuff I shot with it that I want to edit. I downloaded someone elses mts from a hacked GH2 and it VLC reported the frame rate as 100 - which makes me think that for some reason it doubles the reported frame rate.This footage was reported correctly in ppro and played fine.
The thing is although media info reports 25fps on my clips, its definiately 50p. If I put some of it on my timeline and export movie it does export correctly (without jitters) and in slow mo.
Still head scratching :/
I'd double-check those exports.
The original clip duration is locked, The original clip speed is 50 fps. Pr imports the clip at 25 fps, but with the original duration. That means only half the frames ever get into Pr. I can manipulate the video in Pr and the AME so that it syncs perfectly with the clip audio, but only the first half of the clip. The frames from the second half of the clip never make it into the export/re-timing chain because they never got into Pr or the AME in the first place.
Do you get similar results?
NB: I think Pr knows the extra frames are there, but because the clip's duration is a constraint, it doesn't know what to do with them. I think that's why I get random frames appearing from later in the clip when I play the clip back in the Source Monitor or in the timeline. Yet another way to have lots of fun with temporally-compressed footage!
Hi Jeff, yes that sums it up: I can export OK because I'm only exporting from the first half of the clip.
I just tested it with the new firmware and it looks OK - VLC reported the framerate as 100, and appeared to import into premiere at 50fps with no stuttering weirdness.
Which is great for future stuff but now I just need to work out how to fix the footage I've already taken.
You said that there was text in the file, I was wondering if its possible to hack that info? As I said VLC plays it fine (and would rather not reencode frame by frame with something like super, as theres lots of footage). Thanks for your help


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U.S. News Rankings
Ranking score and category | |||||
Patten University is a private institution that was founded in 1944. It has an urban setting and the campus size is 8 acres. It utilizes a semester-based academic calendar. Patten University's ranking in the 2014 edition of Best Colleges is Regional Colleges (West), Tier 2. Its tuition and fees are $8,036 (2012-13).
School mission and unique qualities (as provided by the school): | |
Patten University strives to provide students with a quality Christian liberal arts education through Learning, Faith and Community. "Learning" includes experiences inside and outside the classroom and integration of past, present and future perspectives. "Faith," with God as the starting point, seeks to nurture spiritual development through Bible study, prayer, and worship. "Community" expresses our desire to reach beyond individual interests and concerns, share common interests, and care for those in our campus community and nearby cities. In short, we help students develop excellent learning skills, a vibrant faith, and a sense of belonging in the family of God. |
General Information
School type | private, coed college |
Year founded | 1944 |
Religious affiliation | interdenominational |
Academic calendar | semester |
Setting | urban |
2012 Endowment | N/A |
When applying to Patten University, it's important to note the application deadline is rolling. Scores for either the ACT or SAT test are due August 1. The application fee at Patten University is $30. It is less selective.
For more information about the tests, essays, interviews, and admissions process, visit the Applying to College knowledge center.
Selectivity | less selective |
Fall 2012 acceptance rate | N/A |
Application deadline | rolling |
SAT/ACT scores must be received by | August 1 |
Academic Life
The average freshman retention rate, an indicator of student satisfaction, is 20 percent.
Class sizes | N/A | |
Student-faculty ratio | N/A 4 | |
4-year graduation rate | N/A | |
Five most popular majors for 2012 graduates | ||
Student Life
Patten University is part of the NAIA athletic conference.
Total enrollment | N/A |
Student gender distribution | N/A |
Undergraduate men who are members of a fraternity | N/A |
Undergraduate women who are members of a sorority | N/A |
Collegiate athletic association | NAIA |
Campus Info & Services
Patten University offers a number of student services including nonremedial tutoring, placement service, and health insurance. Patten University also offers campus safety and security services like late night transport/escort service, lighted pathways/sidewalks, student patrols, and controlled dormitory access (key, security card, etc). Of the students at Patten University, 80 percent have cars on campus. Alcohol is not permitted for students of legal age at Patten University.
Students who have cars on campus | 80% |
Health insurance offered | Yes |
More About Campus Info & Services
Paying for School
Paying for college doesn't have to be difficult or devastating. Go to the Paying for College knowledge center to get advice on raising cash and reducing costs.
Tuition and fees | $8,036 (2012-13) |
Room and board | $8,500 (2012-13) |
Financial aid statistics | N/A |
* Overview details based on 2012 data


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June 2nd, 2013, 09:24 PM | #1 |
can you hear the banjos?
2x 90's club car ds
yep, both run good, both look good, aluminum framed, decent tires,36 volt, older batterys but hold and take charge well (we ran it for a soild 2 hours constant on mothers day without issue) good cables,lestronic automatic charger,i will get pictures tommorow when i can pull it out barn
posting here first no bullshit offers $1100 obo 850 for the other only trades toward: firearms, car hauler 18-20 ft with dovetail , extremely nice transjack pics to follow
You can call me Mr. Jefferson Last edited by unclebeaner; June 4th, 2013 at 08:26 PM. |
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The Dyson DC40 Origin has room to improve
The Dyson DC40 Origin is the least expensive model in the Dyson line of upright vacuums. It's a sleek-looking vacuum with all of the attributes you expect from a Dyson product such as the ball technology and bright coloring, a yellow-orange in the case of the DC40. The DC40 performed well enough, but we have some concerns about its overall durability, concerns you shouldn't have with a $399 vacuum.
Given that we have tested the $499 Dyson DC50 and the $649 DC41 Animal Complete, the DC40 had big shoes to fill in terms of performance. In addition, it … Read more


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WTF Is That?!?: A Frozen Blood Head
Let's cut right to the questionable chase: this is a sculpture (or mold) of artist Marc Quinn's head made from 4.5 liters of his own frozen blood. Really gets you in that Halloween spirit, doesn't it? No, not so much.
The blood is taken from this own body over a period of five months. The work is then repeated every five years to establish a unique record of the artist aging.
Now I'm not here to judge art, but that seems pretty sick. Plus, what if the power goes out on your freezer while you're away on vacation? How do you explain the 4.5 liter bloodstain in your garage? You hunt deer. That was a freebie -- next time, you owe me.
Creepy And Disgusting "Self" Art By Equally Creepy Artist Marc Quinn [youbentmywookie]
Thanks to eric, who once made a head out of frozen orange juice concentrate. It was delicious.
Paul Hazelton collects dust and then shapes it into things and calls it art. Me? I vacuum it up LIKE A NORMAL GOTDAMN PERSON. I swear, whatever happened to chiseling marble? 'I think it all has something to do with the fact that I was brought up in an immaculate environment... / Continue →
LOLTATZ is like LOLCATZ but instead of cute animals there's a bunch of questionable tattoos. Obviously some people don't recognize a Metroid when they see one, but that's okay. I posted a bunch of my favorites after the jump, which you should definitely look at because most o... / Continue →
First of all, I predicted the Steelers would win the Super Bowl in a post a couple weeks ago. So I am officially magic. And also, I have a fat face. So thank God for this Japanese face slimmer. It's basically a rubber mask you wear to pretend you're a homicidal cannibal and... / Continue →


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Bud Powell
Earl Rudolph "Bud" Powell (September 27, 1924 – July 31, 1966) was a jazz pianist who was born and raised in Harlem, New York City. His greatest influences on his instrument were Thelonious Monk, who became his close friend, and Art Tatum. Along with Charlie Parker and Dizzy Gillespie, Powell was a key player in the development of bebop, and his virtuosity as a pianist led many to call him the Charlie Parker of the piano.
Read more artist reviews on


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Town Square
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School board eyes job restorations, smaller classesAfter years of paring down its budget, the Pleasanton School Board is considering bringing back some jobs permanently and...
Original post made on Feb. 13, 2014Last comment by Bravo Chimest, on Feb 14, 2014 at 9:51 am | 4 comments | 1587 Views
We the People - Civics CompetitionCongrats to the Amador Valley and Foothill students and coaches on their performance at the state level in Comp Civics! ...
Original post made by Citizen on Feb. 13, 2014There are no comments yet. 234 Views
Court extends deadline for California prison reductionA federal three-judge panel Monday gave Gov. Jerry Brown's administration a two-year extension of a deadline for reducing...
Original post made on Feb. 11, 2014Last comment by Lock 'em Up, on Feb 13, 2014 at 7:17 pm | 7 comments | 1082 Views
Malatesta new president of Pleasanton Downtown AssociationVic Malatesta, owner of Vic's All Star Kitchen on Main Street, was installed Tuesday as the new president of the Pleasanton...
Original post made on Feb. 13, 2014Last comment by mg, on Feb 13, 2014 at 3:19 pm | 2 comments | 1452 Views
Funding questions loom over high-speed rail's new planSeeking to comply with a legislative requirement, the agency charged with building California's high-speed-rail system on...
Original post made on Feb. 11, 2014Last comment by Cholo, on Feb 13, 2014 at 1:47 pm | 11 comments | 1590 Views
Ceremony today to name Bay Bridge after Willie BrownThe Bay Bridge's western span is being officially renamed today after former San Francisco Mayor and state Assembly Speaker...
Original post made on Feb. 11, 2014Last comment by nancy s., on Feb 13, 2014 at 1:03 pm | 17 comments | 1657 Views
Metering Light is Causing GridlockWhy is Caltrans allowed to turn on freeway metering lights when doing so causes gridlock on city streets? Today was the worst...
Original post made by Bill on Feb. 3, 2014Last comment by Driver, on Feb 12, 2014 at 7:15 pm | 43 comments | 1866 Views
Pleasanton schools closed todayPleasanton schools are closed today in honor of Lincoln's birthday and then again next Monday, Feb. 17, for Presidents' Day. Read...
Original post made on Feb. 10, 2014Last comment by john, on Feb 12, 2014 at 10:33 am | 11 comments | 1535 Views
What happened to the story about PPD dispatcher bust!There was a story about PPD dispatcher getting busted with meth! It was here this morning.......
Original post made by republicrat on Feb. 11, 2014Last comment by republicrat, on Feb 12, 2014 at 9:50 am | 3 comments | 505 Views
Feit out as CEO at ValleyCare Health SystemMarcy Feit, ValleyCare Health System's president and chief executive officer since 1997, quit her post suddenly Tuesday,...
Original post made on Feb. 6, 2014Last comment by furbur, on Feb 12, 2014 at 9:37 am | 29 comments | 7824 Views
School board to ponder restoring jobs, smaller classesThe Pleasanton school board will be looking at whether to permanently bring back some of the jobs it restored on a one-time...
Original post made on Feb. 11, 2014Last comment by local, on Feb 11, 2014 at 8:49 pm | 4 comments | 815 Views
AAUW Offers Scholarship to Local WomenThe Livermore-Pleasanton-Dublin branch of AAUW is now accepting applications from college women who will be of junior standing...
Original post made by Joan Leighty on Feb. 6, 2014Last comment by Cholo, on Feb 11, 2014 at 10:46 am | 2 comments | 321 Views
Not a single story about the healthcare disaster?The silence is deafening....
Original post made by Kangaroo on Nov. 5, 2013Last comment by Formerly Dan from BC, on Feb 11, 2014 at 7:52 am | 101 comments | 2475 Views
New state funding formula means more money for Pleasanton school districtPleasanton schools can anticipate some extra cash through a new state funding plan that restructures how districts are funded. Read...
Original post made on Oct. 10, 2013Last comment by Jull, on Feb 10, 2014 at 5:06 pm | 4 comments | 1344 Views
Special beef cuts recalled by Petaluma producerA Petaluma-based company recalled more than 8.7 million pounds of meat Saturday produced over the last year that may not...
Original post made on Feb. 10, 2014Last comment by Sam, on Feb 10, 2014 at 12:50 pm | 5 comments | 2871 Views
Cristiano named honorary president of Pleasanton real estate firmJanet Cristiano has been named honorary president of Better Homes and Gardens Mason-McDuffie Real Estate. Read the full...
Original post made on Feb. 10, 2014Last comment by Community Member, on Feb 10, 2014 at 12:07 pm | 2 comments | 866 Views
No charges in case where man was left comatose outside his homeNo charges will be filed against the teens involved in an altercation that left a Middleton Place man bleeding and unconscious...
Original post made on Feb. 7, 2014Last comment by William H Tell, on Feb 10, 2014 at 11:38 am | 75 comments | 5943 Views
Truck, tools stolen from construction siteA truck and tools valued at nearly $58,000 were stolen from a construction site at the Stoneridge Creek retirement community...
Original post made on Feb. 6, 2014Last comment by Dave, on Feb 9, 2014 at 5:28 pm | 4 comments | 1365 Views
Pleasanton declares water emergency due to statewide droughtThe Pleasanton City Council declared Stage 1 of water shortage planning at its meeting last night in response to Governor...
Original post made on Feb. 5, 2014Last comment by b, on Feb 8, 2014 at 5:16 pm | 57 comments | 4385 Views
Trial date set for lawyer charged in Dublin hit-and-run deathNearly two years after being arrested for running down a bicyclist in Dublin, felony charges are moving forward for a San...
Original post made on Jan. 17, 2014Last comment by Cholo, on Feb 8, 2014 at 12:44 pm | 3 comments | 1075 Views
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RainSaucers School Art Contest
By Roz Rogoff | 7 comments | 1,145 views
Torches and Pitchforks 52 Rule of Law 47
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Two lives well lived
By Tim Hunt | 1 comment | 670 views


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Emmy Award-winning Reporter Jim Altman came to FOX CT in 2005 after some memorable stops along the way.
Jim began his career at NBC as a member of the prestigious NBC Page Program. After NBC, Jim joined the staff of the ABC Newsmagazine 20/20 where, as an Associate Producer, he spent eight years traveling the country for some of the network's most high-profile stories.
The on-camera bug bit him a few years ago and Jim landed his first full-time on-air job at WAMI-TV, Miami as a reporter for the critically-acclaimed South Beach News Magazine "The Times." When WAMI-TV was sold to a Spanish language network, "The Times" was canceled. Jim quickly found himself tapped as the host for the "Mervyn's Beach Bash," a nationally televised extreme sports program shot in Los Angeles.
Jim joined WSYX-TV (ABC/FOX) in Columbus, Ohio where he covered the Ohio State Buckeyes championship season and kept on the trail of the presidential candidates in the pivotal Ohio election. In just over two years in Columbus, Jim won four Emmy Awards for news reporting, including the Midwest Emmy Award for Best Feature Reporter.
In 2005, Jim joined Fox CT News and has covered most major news events in the state since then, in addition to his weekly travel segment "Daytrippers" which he co-hosts with Sarah Cody. Jim's critical acclaim has continued in Connecticut. In 2006 he won the New England Emmy Award for Feature News Reporting. In 2007, Jim won three Emmys: Health and Science Reporting, Sports News Reporting, and Overall News Writing. In 2008, Jim won the Emmy Award for Overall News Writing and was honored with the Associated Press Award for General News Reporting. In 2009, Jim won the Emmy Award for Fox CT's travel segment, Daytrippers.
From 2011 to 2012 Jim took home the Boston/New England awards for Best Feature Reporter (both years), Feature News Single Story, Spot News Reporting, and News Writer. Jim was also honored with the Associated Press Awards for News Writing, Feature News Reporting, and Spot News Reporting.
This year, Jim became a 20-time Emmy Award recipient wining the Boston/New England awards for Best Feature Reporter, Feature News Single Story, Sports Reporter, and Outstanding News Writer.
In his spare time, Jim supports charitable causes. He is currently the host of the Muscular Dystrophy Association's Labor Day Telethon and numerous MDA events throughout the year. Jim also serves as emcee for an array of fund raisers around the state and is especially proud to represent Hartford-based Camp Courant.
Raised in Washington, D.C. and New York City, Jim is a graduate of Syracuse University and remains an avid Orange Fan. He also still admits to being a Redskins fan.
6 hours ago by Jim Altman Reporter/Travel Host
3 days ago by Jim Altman Reporter/Travel Host
6 days ago by Jim Altman Reporter/Travel Host
03/03/14 by Jim Altman Reporter/Travel Host
02/28/14 by Jim Altman Reporter/Travel Host
02/27/14 by Jim Altman Reporter/Travel Host
02/25/14 by Jim Altman Reporter/Travel Host
02/24/14 by Jim Altman Reporter/Travel Host
02/21/14 by Jim Altman Reporter/Travel Host
02/18/14 by Jim Altman Reporter/Travel Host


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I was catching up on the news of the week when an article titled, "Gay Marriage Is an Abomination Before God" caught my eye in the newsfeed. Curious, I clicked over to read more. The article serves as a plea to North Carolina voters to vote for Marriage One on May 8, 2012. The author's reason:
Many do not see this, but where we are headed is the jungle, where homosexuality, lesbianism, transgender, bestiality, pedophilia and any other conceivable behavior is a self-proclaimed right.
Dwight Creech's words may create a sense of sadness or anger in some. His words should also generate fear. There are people out there like Mr. Creech that actually think committed gay or lesbian couples should be compared to pedophiles – and that's just scary.
So if you're wondering why so many people are out there speaking out against these mean-spirited amendments, it's partially because they fear people like Dwight Creech. When an individual has no qualms of putting this kind of hateful speech out there for public view, you've got to wonder how far they would be willing to go. Who is next in Mr. Creech's crosshairs?
If you don't like to see or hear things like this, you must lend your voice to the fight. North Carolina is literally just weeks away from a very heated vote on this so-called marriage amendment – we can't allow this mean-spirited amendment to pass because we sat idly by and were quiet on the sidelines.
The same is true here in Minnesota. There are Dwight Creeches in every state out there. We must stand together and say No More.
North Carolina, I'm hopeful you will stand together in May and say NO to Amendment One. Minnesota, I'm hopeful we will stand together in NOvember and say no to our very own marriage amendment. And Dwight Creech, I will say an extra prayer for you tonight: may you see your judgement on others as a direct conflict to the very teachings you profess.


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NPDES Meetings and ConferencesOften WPD sponsors or co-sponsors meetings and conferences related to the NPDES Permit Program and some of its supporting programs and initiatives. The following provides a list of meetings and conferences related to the NPDES permit program. Currently the following meeting is scheduled:
Other EPA Water-Related Courses - Provides links to other offices within EPA that provide training courses related to water quality issues. Please try back later or sign up for NPDES News to receive the latest information. |