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37" Class 1080P LCD TV (37.0" diagonal) 37CS560 DOWNLOAD PDF SUMMARY Screen Size Resolution Display Type MPRT No. of HDMI Ports 37" 1920 x 1080p LCD 60 Hz 2 DIMENSIONS / WEIGHT TV without stand (WxHxD) TV with stand (WxHxD) Shipping Dimensions (WxHxD) TV without stand weight TV with stand weight Shipping weight 35.9" x 22.5" x 3.1" 35.9" x 25.2" x 10.4" 45.7" x 26.0" x 6.3" 24.5 lbs 28.2 lbs 35.5 lbs PANEL SPECIFICATIONS Screen Size Class (diagonal) Resolution BLU Type Frame Rate 37" Class (36.5" diagonal) 1920 x 1080p Lamp 60Hz BROADCASTING SYSTEM Analog Digital Yes ATSC/NTSC/Clear QAM (1 Tuner) VIDEO Triple XD Engine Picture Mode Picture Wizard II Aspect Ratio Just Scan (1:1 Pixel Matching) AV Mode (Picture & Sound) Yes 7 Modes (Intelligent Sensor/Vivid/Standard/Cinema/Game/ISF Expert 1/ISF Expert 2) Yes 6 Modes (16:9/Just Scan/Set by Program/4:3/ Cinema Zoom 1/Zoom) HDMI 1080p/1080i/720p, Component 1080p/1080i/720p, RF 1080p/1080i/720p 4 Modes (Cinema/Sport/Game/Off) AUDIO Mono/Stereo/Dual (MTS/SAP) Dolby® Digital Decoder Speaker System Audio Output (Watts - THD 10%) Virtual Surround Clear Voice II Sound Mode Mute (Normal/2 Level) Yes Yes 1 Way 2 Speakers 10W + 10W Yes Yes 5 Modes (Standard/Music/Cinema/Sport/Game) Normal CONNECTIVITY SIMPLINK (HDMI CEC) Yes SPECIAL FEATURES Intelligent Sensor Smart Energy Saving Input Labeling Quick View (Flashback) Key Lock Closed Caption Yes Yes (Backlight Control+Intelligent Sensor) Yes Yes Yes Yes CONVENIENCE FEATURES Language Auto Tuning/Programming Channel Add/Delete Auto/Manual Clock On/Off Timer Sleep Timer Auto Off/Auto Sleep 4 (English/Spanish/French/Korean) Yes Yes Yes Yes Yes Yes AV INPUTS/OUTPUTS RF In (Antenna/Cable) AV In Component Video In(Y, Pb, Pr) + Audio HDMI™/HDCP Input USB 2.0 1 (Rear) 1 (Rear) 1 (Rear) 2 (Rear) 1 (Side) CABINET / ACCESSORIES Swivel (Left/Right) VESA Compatible Remote Control 20º/20º 200mm x 200mm Universal POWER Power Supply (Voltage, Hz) Standby Mode 100V ~ 240V, 50/60 Hz 0.1W WARRANTY / UPC Limited Warranty UPC 1 Year Parts & Labor 719192585164 Expand All SpecsCollapse All Specs Back To Top Design, features and specifications subject to change without notice.
User Reviews 37CS560 4.7 5 364 376 Great valuwe! Great TV for the price! We really like how it fits in our entertainment center. Can't recommend it enough. February 23, 2014 Best Bang for Your Buck The sound this TV has is really good for mundane speakers. Great Picture Quality. Cool little extras for picture adjustments. For the price and brand name, it has to be one of the best TVs out there for its class. June 26, 2013 They sold me a product with missing parts Bought a open product and got burned would never do that again June 21, 2013 AS GOOD AS LAST LG This Replaced my old LG same size and works fine very happy. June 21, 2013 2 3 4 5 ... 92 Next>>


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Iv attached a picture to show the error & my rule text. I have created the Parameters etc. & the statement includes if & end if. Cheers,
Solved! Go to Solution.
If Parameter("HEIGHT")=152.4
If you are finding usnderstanding ilogic difficult, have a go at the online tutorials.
** Use "End IF', not "ENDIF"
Pasting into IE erased the space.
My text in the 'UC_designation' Parameter contains 'x's. E.g - 152.x152x23
Inventor recognises this as an equation, therefor the rule doesnt work. Is there any way around this without replacing the 'x's?
when you created the "UC_PROFILE" Parameter, did you create it as a text parameter?
If not, in the parameters dialogue, use the drop down in the bottom left which by default says "Add Numeric". Select "Add Text" instead.
Cheers Wayne.
This is the first time iv started using Rules. If you havent already guessed!
Do you know if there is a way in which rules can be run automatically? E.g Everytime the part is updated or saved rather then having to press iTrigger
NVM. Iv added the rule into event triggers.
I'm not that knowledgeable about triggers I'm afraid, as I have only really been creating rules which I need to run on command, but have a look at this...
I just realised NVM stands for nevermind so mevermind my last post also!
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subset: commoncrawl


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We want Great Lever to be a safe place for residents to live and enjoy life and we work hard with our partner agencies to achieve this. We encourage neighbours to be friendly towards one another but also if you see crime or anti social behaviour, tell us so that we can do something about it.
The UCAN centre is a designated reporting centre where you can be confident of reporting any hate crime. All our staff have been trained to deal with reports of this nature and we have private and confidential meetings rooms to enable you to feel relaxed and secure whilst you are here. Please contact the centre if you would like to make an appointment to see one of our staff.
Alternatively you may contact the Police or Bolton Council. Details of other hate crime reporting centres can be found on the GMP website.
The police hold regular surgeries at the centre to make it easier for you to report crime and/or anti social behaviour. All reports are taken in the strictest confidence. Please feel free to make an appointment by contacting the centre of drop in on one of the following dates:
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We will ensure our staff have appropriate compulsory training relating to ASB and support including Annual 'refresher training'.
We will keep the identity of victims / witnesses confidential when requested.


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4.7 out of 5
10 Reviews
Nice Jacket
January 10, 2012
As with all things Patagonia, this jacket is well put together and good quality. It is not a super technical coat, not a lot of pockets and zippers, which is good for me. I like this jacket a lot!
Pros: Great designStylish and functional
November 18, 2010
This jacket is well made, warm and shows off a girl's shape. After looking at dozens of ski jackets, I am very happy with this purchase. The only critique is that the sleeves are long for short-armed people like me.
Pros: Great design, Performance, Great valueGreat ski jacket
February 15, 2011
Great product! I wore it skiing in Tahoe, great fit. I am 5'7" 135lb and am somewhere in the small to med size range- I chose the medium and am happy with the choice. With a layer underneath, it fits great and is warm. I have longer arms and the length is great. It's really comfortable, not too heavy and definitely not bulky. It is well-constructed and seems like it will definitely last.
Pros: Great design, Build qualityAlmost Perfect
March 26, 2011
I bought this jacket because it matched my red Patagonia Pants. I like the style and fit. I bought the medium and I weigh 130 pounds 5'5". The two features I wish it had was built in stretchy wrist warmers that slip over your thumb and something similar to that around the neck as those are the only two spots I get cold. It does have the velcro closures around the wrists but those don't seem as effective with big gloves that I take on and off. Overall I would recommend the jacket.
Pros: Build quality, Lasts forever, Performance, Ease of use, Cons: no built in wrist gaitersExcellent quality and warmth without the bulk!
January 12, 2011
I purchased this jacket for my teenage daughter! Although she doesn't do much skowboarding, she wanted a jacket that provided warmth without the "bulk." If this is what you're looking for then the Patagonia Insulated Snowbelle is the jacket for you!!! The fabric and construction is of supreme quality! I would definitely recommend this jacket!
Pros: Great design, Build quality, Lasts forever, Performance, Ease of use, Great value, not bulkylove this jacket... but maybe it pills a bit?
January 19, 2011
so i tried on a ton of jackets at patagonia and i love this jacket... the fit and style of it are very cool. love the storm velcro flap at front. the fabric is really nice... a very subtle herringbone texture, very dark black... not too shiny and very soft. i can wear this in the city or on the slopes. this is super waterproof... have worn it in pouring rain in the city and also snowstorms on the slopes, and the water rolls right off. only worn this about 10 times but starting to notice a bit of pilling on the fabric under my wrists... worried about how this will look long term.
Pros: Great design, Build quality, Performance, Ease of use, Cons: might be pillingNice Fit and Warm
October 29, 2012
Bought a small (5'5"/~128#) and fit is flattering yet still can layer underneath; a bit shorter waisted than some but definitely long enough to be comfortable and warm. Quite high colar but works well for me as I can't stand to be cold around the neck. Typical Patagonia quality and design; best around in my opinion. Really looking forward to getting a lot of use out of this jacket.
Pros: Great design, Build quality, Lasts forever, Performanceoverall great jacket
January 13, 2012
I had been in the market for a new ski jacket for a while, and after trying on numerous brands, I finally settled on the Patagonia Snowbelle. This jacket has a great fit, it is flattering to a woman's body and is long enough in the back to keep you warm when on the ski lift. I am petite and ordered an xs, it fits perfectly. The arm length is just perfect and I love that the hood is insulated as well as removable. The pockets are great and the pit-vents are easy to pull open when needed. I have worn this skiing in the Catskills and Telluride, and it held up great even in wet conditions. You definitely have to layer underneath as this jacket is warm, but is not windproof in chilly conditions. The mobility in the jacket is great as even when layered, you have excellent freedom of movement. Overall this is a great purchase and for a Patagonia product, a great price. I highly recommend!
Pros: Great design, Build quality, Ease of use, Great value, Cons: not windproofJanuary 11, 2011
This was my first Patagonia purchase, and it was a success. I wanted a warm waterproof ski coat, but couldn't decide between realiable North Face or Patagonia (a friend recommend the latter to me). I decided to go out on a limb and order this jacket because I liked the color and all the amenities. After receiving the jacket, I am pleased with my decision. The natural color is lovely, with the blue accent giving it some color! I am 5'5'', 130 lbs, and this jacket is a touch loose, but when I layer under it, I am sure it will fit perfectly. The arms are a bit long, so I rolled the cuffs up and it looks super cute with the blue lining showing. Overall, I am very satisfied with my purchase and would recommend this jacket!
Pros: Great design, Build quality, Cons: CostOctober 16, 2012
This is a great jacket for being on the slopes all day! It is very warm. There are many pockets to store things while on the slopes. They work well with the snowbelle pants.
Pros: Great design, Build quality, Great valuePatagonia Women's Insulated Snowbelle Jacket-154884 Photo
Black, Marathon Blue, Northern Lights/ Aloe Green, Northern Lights/ Birch White and Wax Red.
Available sizes, while supplies last, include size xs, size small, size medium, size large and size extra large: xs, s, m, l, xl.


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By Pagosa Springs SUN Fun with LEGOs for kids 6 through 13. Bring your imagination…the LEGOS are provided. This month: Robots. Please contact the library at 264-2209 for further information. Free. Follow these topics:
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The floor looks great and although a little time consuming, pretty easy to install!
We love our new floors! The customer service by Porscha Brown was more than excellent! She seemed to always be there to answer any question we had about the flooring. We selected the "8mm Coffee Creek" and are so happy with the way it installed (by my husband) and the way our home looks! The rooms are much brighter & even bigger without that old stained carpet. Initially we were doing the kitchen & living area, but we overestimated our needs so now we have done those and the front room + the hall and my office! Folks have thought we had cork installed. The seams are not visible with this pattern. The hardest part to install was the hallway because of the many doorways. Fortunately as he worked, my husband kept a basket of "pieces" so that he did not have to sacrifice many of the whole tiles. We have lots of dogs & this is wonderful! It vacuums easily. When the dogs were ill and vomited, the floor did not suffer..just a damp paper towel to clean the mess! Our Kaya, a white Huskey, loves to walk in the water outside and then come in...only need to take an old-fashioned mop to dry the floor!
Happy Customer
Images sent in by happy customer
The product is fantastic. I am use to it because of the gym I am a member off. However the installation video is very deceiving. We did a 12x15 room and it took us 5 hrs. All the angle cuts, cutting the product is very hard and a blade knife does not do the trick. We had to use shears. Regardless, many hours of work but when it's all done its all worth the hours. We installed 8mm but if you instal something thinner then cutting would be a lot easier.
This is a very good product. there is not a better floor to put in your home gym. good price, great quality, easy of installation, great looks. I put in the 8mm roll in a 12' x 21' room. I looked for months and chose this flooring, I'm glad I did.
This whole process went so smoothly. From the order to receiving the product. The price was also very much less than buying locally. The sales associates on the phone were helpful and gave me good advice. The sample confirmed what I was told and now my gym floor looks terrific. Looks as though it will last a lifetime. The delivery time was earlier than expected. What a great company. I am always hesitant to order a big item like this online but I know I did alot better than ordering from a local flooring store. WOW thank you and I would tell everyone to use Rubber Flooring Inc........
We just installed black diamond plate rubber flooring in our new office entry and bathrooms. It was very easy to install and looks fantastic. It creates a very clean, stylish, and easy to maintain look.
Very pleased with how the room turned out. Product makes the room look great. Templated the unique shaped room on graph paper to determine best use of length and quantity of rolls. Installed the 300 square foot room myself. Sharp blade and a straight edge made it go quick. Did not use adhesive as the product relaxed quickly and layed flat. The weight of the product and tight fit keeps it in place. The seems lay down well together so there was no need to tape them. Buy it!
Both sales people we dealt with at Rubber flooring Inc. were extremely helpful, polite, knowledgable and did not try to up-sell me on any unnecessary accessories or products. A sales staff that does their job should not be rare, but unfortunately it is, so we were very pleased with the customer service. Also, the designer series rubber roll we ordered as a temporary fix for our flood-damaged kitchen floor, arrived when promised, in perfect condition, and looks great. We love it! We highly recommend ordering from this company.
Your product is the foundation of our family gym. Thank you for your exceptional assistance throughout the entire process.
quiet, warm, soft, easy to install, easy to clean, won't stain, rot, mildew,
Can't complain at all. Very affordable and exactly what I was looking for.
Easy installation and a quality product
I LOVE my rubber floor. We put it down in an old wash house that I converted to a workout room. I am amazed at how attractive and comfortable it is. We had 3 rolls and the seams are almost completely unnoticeable. I thought it would show dusty footprints, but it doesn't. I believe that is b/c I went with a designer series. It's just so awesome, and I would highly recommend it. It was easy to put down. Just needed an extra hand for a little adjustment once in awhile, but basically a 1 person job.
Dustin was helpful in entire process. flooring delivered as expected. (trucking company was ok,. I had to help off-load truck), but all is well. My son and I installed the floor and it looks great. would recommend flooring to others.
The product has great quality and looks awesome in our new weight room. The customer service was outstanding as well.
I was referred to Rubber Flooring Inc. by a friend. They had exactly what I wanted at a great price! To top it off; Rubber Flooring, Inc. has excellent customer service. I could not be any more pleased! I would HIGHLY recommend Rubber Flooring, Inc. many many more times!
Great stuff. really makes the Gym. Love it thanks
I wanted something with some more color in it then normal so I chose the rocky road color for my newly remodeled personal training studio. I have a couple of Precor ellipticals, 3 Life Fitness treadmills, 2 stationary Motus bikes, multiple free weights, lifting stations, lifting racks, etc. I personally train discreet clients with discerning tastes so I had to make sure the place looked and felt top notch. The flooring turned out great and my clients have had nothing to offer but rave reviews at my remodeled private gym. The service was great too every step of the way. Thanks.


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First of all, it took nearly two weeks to receive this ring, which is annoying when I had always heard that overstock has amazingly fast shipping. Anyway, the ring is very pretty. The stone is big, although it has much less color than the one in the picture and is almost clear. In some low lighting it has a bluish tint, I like an aquamarine that oisn't too blue, just know that it also could look like you a wearing a big fake diamond. The band is nice and dainty. The diamonds in the halo and along the side are pretty cloudy,, but honestly it's what I would expect at such a low price! Overall if you don't mind a nearly clear stone I would recommend this ring.
I received this ring lastnight from my boyfriend as a promise ring. He picked it out on his own. =) Anyways, he said it took 3 weeks to come in and he was even worried it wouldn't come in time, so shipping is horrible. Maybe overstock should switch who they ship with? On to the actual ring, many reviews complain about the faintness of the blue, but in my opinion its gorgeous. Aquamarine (my birthstone) is a light blue anyways. However, the diamonds along the band and stone are very milky white, again i'm not complaining because I love it either way =) the stone is veryyyyyyyyyyyyy sparkly!! The band is very...dainty I guess. I was worried it would look ridiculous on my chubby fingers, but it looks great =)
It is not an exaggeration to say that when I opened the box my heart started singing. How could such an inexpensive ring be this beautiful? I have never cared for my birth stone because it always looked blah boring, so I held no high hopes for this one. I was so suprised at how good looking this one was. The stone is a perfect size and though I wish the band was a bit thicker, I paired it with a thin diamond accented band and it sparkles so beautifully . The aquamarine is a pale pale blue that draws the eye but remains understated and easily worn everyday which I have done since receiving it in the mail 4 weeks ago.
I love the design of this ring but unfortunately the stone color was too light which made me think it would be mistaken for a diamond. Since I'm about to get engaged, I didn't want people guessing if this was "the ring". Other complaints are 1. the diamonds in the band are milky white and 2. the band is extremely skinny - to the point that I felt like if I banged it a little it would bend or break. The size of the center stone is good though and the design is very pretty so if you don't mind an almost clear stone and a super thin band, this ring may work for you.
I know for *** you can't expect the diamonds to be perfect, but these diamonds were very milky and the aquamarine was clear. It was almost impossible to find a blue tint to the stone at all. That being said the style of the ring is lovely and runs true to size. If the aquamarine was bluer I would have kept the ring and lived with the milky diamonds. The stone was very shiny and large!
This ring looks expensive but what a great value! I love that it is so dainty. The color is absolutely beautiful.
The fit and style are accurate. Color looked like a cubic zirconia/diamond...not aquamarine.
Although the stone is very light blue, I still love this ring. I Iove the setting and the stone is clear and beautiful.
The aquamarine is not blue, so the ring ends up looking like a cheap engagement ring. Incredibly disappointing.
My birthstone is aquamarine so I have several pieces but this one is way too light. This really looks like a diamond. The only time I can catch a glimmer of the faintness blue is if I'm looking in the mirror at the ring on my finger. The surrounding diamonds are small and pointless. The center stone is clear and not cloudy so it is really pretty, but looks like a diamond. A better design would be with the center stone as a solitaire.
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Item #049K In Stock
Avg. Rating 5 reviews
Our Price: $79.95
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The VCBD1611 bagged cylinder vacuum cleaner is the ideal way to keep your home spotlessly clean. Its lightweight design means this vacuum is easy to use and transport around. A range of tools is included with the VCBD1611 such as a crevice tool for detailed cleaning. What's more, a HEPA filter and 4 levels of filtration helps eliminate particles that may cause sneezing and allergic reactions. This vacuum cleaner's 1600W motor plus 230W suction power ensures maximum efficiency to save you time and effort. There is cord rewind for flexible cleaning. The full bag indication will maintain the performance of the vacuum.
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text: The 13 Most Important Numbers in the Universe Some numbers, such as your phone number or your Social Security number, are decidedly more important than others. But the numbers on this list are of cosmic importancethey are the fundamental concepts that define our universe, that make the existence of life possible and that will decide the ultimate fate of the universe. In this piece adapted from his new book Cosmic Numbers: The Numbers That Define Our Universe, California State University, Long Beach, mathematics professor James D. Stein reveals not only the effect each number has on our lives and our universe, but also the story of the people who discovered and worked with them. Here they are, in the order in which science first became aware of them. By James D. Stein Email Comments 0 Share Back 4 of 13 Next Return to Gallery Return to Gallery Return to Gallery ESA/NASA Back Next View Larger View Thumbnails 4. Absolute Zero It's easy to make heat. Humans have been able to capture or create fire since prehistoric times. Producing cold is a much more difficult task. The universe as a whole has done a very good job of it, as the average temperature of the universe is only a few degrees above absolute zero. And it has done so the way that we do it in our refrigerators: through the expansion of gas. Michael Faraday, who is far better known for his contributions to the study of electricity, was the first to suggest the possibility of producing colder temperatures by harnessing the expansion of a gas. Faraday had produced some liquid chlorine in a sealed tube, and when he broke the tube (and thereby lowered the pressure), the chlorine instantly transformed into a gas. Faraday noted that if lowering the pressure could transform a liquid into a gas, then perhaps applying pressure to a gas could transform it into a liquidwith a colder temperature. That's basically what happens in your refrigerator; gas is pressurized and allowed to expand, which cools the surrounding material. Pressurization enabled scientists to liquefy oxygen, hydrogen and, by the beginning of the 20th century, helium. That brought us to within a few degrees of absolute zero. But heat is also motion, and a technique of slowing down atoms by using lasers has enabled us to come within millionths of a degree of absolute zero, which we now know to be slightly more than 459 degrees Fahrenheit. Absolute zero falls in the same category as the speed of light. Material objects can get ever so close, but they can never reach it. Return to Gallery Return to Gallery Return to Gallery Return to Gallery Return to Gallery Return to Gallery Return to Gallery Return to Gallery Return to Gallery Return to Gallery Back 4 of 13 Next Return to Gallery Back Next Return to Slideshow Related News


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The N.C. Wildlife Resources Commission will offer a special fly-fishing weekend for women through the Becoming an Outdoors-Woman program on March 9-11 in the mountains.
Activities will be held at the Pisgah Center for Wildlife Education and Davidson River Campground, south of Asheville, near Brevard in Transylvania County. The registration fee is $125, with partial scholarships available.
"It doesn't matter what skill level or previous experience you have," said BB Gillen, outdoor skills coordinator for the Wildlife Commission."
This weekend is tailored for individuals, so each angler will gain new skills and improve techniques, and learn about an angler's important role in conservation on mountain streams."
Fly-fishing equipment will be provided, but participants can bring their own gear.
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Chapter 8: Thesis and Examination Matters
8.3 Appendix 1- Thesis Submission and Examination Process
PhD candidates should refer to the 'Doctoral Information Handbook' for their preparation and submission requirements.
8.3.1 Stage 1 - Submission
Preparing for submission of your Masters thesis
A research candidate about to submit a thesis is advised to read the appropriate sections in this 'Survival Guide' and if in doubt on any point should also consult the ARGS . Masters candidates are required to follow the guidelines outlined under the heading 'Preparation and Presentation of a Masters Thesis' in this chapter and this appendix.
Pre-submission meeting
The research candidate organises a pre-submission appointment with the main supervisor and the Graduate Coordinator to complete and sign the necessary documentation. Three forms are required at the time of submission:
'Masters Thesis Submission' form - candidate completes and signs Section A to enable the examination process to begin. The supervisor completes and signs Section B to certify that the research and writing embodied in the thesis is that of the research candidate, except where otherwise acknowledged in the thesis, that the thesis is properly presented and is prima facie worthy of examination and that the thesis is within the stipulated word length for the course. IF the supervisor has any reservations, s/he will state this in writing and the candidate needs to countersign the form in Section B to indicate that you are aware of the supervisor's reservations. This form is to be submitted with the thesis to the ARGS. In cases where the supervisor is not prepared to sign off on a thesis, see under the heading 'Submission' above.
'Library Release Authorisation' form - the candidate needs to complete and sign, then the supervisor signs to ratify on behalf of the school. This form is to be submitted with the thesis to the ARGS so that the thesis can be distributed after successful examination and binding.
'Nomination of Examiners' form -Your Supervisor informally contacts the examiners to ask if they would be prepared to act as examiners, that they can complete the examination within 6 weeks and to check the examiners' contact details on the form are correct (address, email and telephone). Once completed the School forwards the Nomination of Examiners form to the ARGS - this form is not to be left with the candidate (for compliance with Privacy legislation). For more information on 'Appointment of Examiners' see Section 8.1 above under that title in this chapter.
Submission of the thesis for examination
The research candidate submits three copies of the thesis, the completed 'Masters Thesis Submission' form and the 'Library Release Authorisation' form to the Arts Research Graduate School office, room W205, Menzies Building, Clayton Campus.
Candidates can request a photo be taken at the ARGS, free of charge, at the time of submission as a reminder of this important event.
The School Graduate Coordinator, Graduate Administrator or the candidate's Supervisor submits the 'Nomination of Examiners' form to the ARGS on the day of submission or as soon as possible.
Candidates on Scholarships
Candidates in receipt of scholarships must notify the MRGS that they have submitted their thesis on the day they submit. Failure to do so will result in a claim for any overpayment which may occur.
ARGS Checks the Submission
Once submitted, the ARGS staff will check that the thesis contains the contents specified (in Section 8.1 under the heading 'Word Processing, Printing and Binding' in this chapter) and that the thesis falls within the appropriate thesis word length (see Section 8.1 under the heading 'Length' in this chapter). If the thesis is under/over length the Supervisor needs to write to the ARGSC to explain the reasons for the length and to seek permission on the candidate's behalf to submit an under/over length thesis. When informally contacting the examiners, the supervisor needs to advise them of any irregular word length.
If the theses and the paperwork satisfy the requirements for submission, the thesis examination process will commence. If the thesis fails to meet the stipulated requirements or the submission forms are incomplete, the theses and forms will be returned to the School and the candidate will be asked to arrange for corrections.
8.3.2. Stage 2 - Examination
ARGS Sends the Thesis to the Appointed Examiners
Each of your examiners receives:
One copy of the thesis
One 'Masters Thesis Examiner's
Report' form
Instructions for examiners
letter requesting the examiner notify ARGS if they are unable to
return the report within six weeks.
ARGS Notifies the Candidate of Examiners
The candidate is sent a letter informing of the official appointment of the examiners' and that the thesis has been sent out for examination. This letter contains specific advice about the University's strict policy that all communication with examiners on any matter relating to thesis examination must be through the ARGS and that infringement of this rule risks disqualification of the thesis.
ARGS Reminds Examiners to Return 'Masters Thesis Examiners Report'
If one or both of the examiners' 'Masters Thesis Examiner's Reports' is not received within the stipulated timeframe, the ARGS sends a reminder letter to the examiner(s) seeking advice on the expected examination completion date.
ARGS Receives 'Masters Thesis Examiners' Reports'
The examiners return their reports and your theses to ARGS. The examiners can recommend on of the following outcomes:
Pass straight award - See Scenario A1
- Pass subject to the completion of amendments - See Scenario A2
Revise and resubmit - See Scenario
Fail - See Scenario C and/or D
8.3.3. Stage 3 - Possible Masters Thesis Examination Outcomes
In summary, this section outlines the process for the following outcomes or scenarios:
- straight award
- subject to the completion of amendments
Revise and Resubmit (R&R)
Fail -
Scenario a - Both Examiners Recommend the Masters Thesis Pass with Either Straight Award (Scenario A1) or Subject to the Completion of Amendments (Scenario A2)
Scenario A1 - Pass - Straight Award
Research candidate is awarded the degree without further examination.
ARGS returns two unbound copies of the examined thesis to the research candidate with a letter requesting that the candidate bind two copies. These two bound copies are then returned to the ARGS (you are advised to bind an extra copy for personal use as binding in quantity is cost effective).
The third unbound copy is returned to the candidate once ARGS receives the two bound copies (if you hand-deliver these copies you can collect the unbound copy).
ARGS sends one bound copy to your school and one to the Library. Each bound copy contains the 'Library Release Authorisation' form signed at the time of submission.
See 'Completion' below.
Scenario A2 - Pass Subject to the Completion of Amendments
Candidate is awarded the degree subject to the completion of amendments requested by one or both examiners.
ARGS returns two unbound copies of the original thesis to the candidate, with a letter advising the candidate to discuss the amendments with the supervisor before attending to them. On completion of amendments the candidate organises binding and returns TWO AMENDED AND BOUND copies to ARGS.
ARGS sends one bound copy and a 'Library Release Authorisation' form to the school and asks the graduate coordinator to certify the successful completion of amendments. The school retains this bound copy. If the school graduate coordinator does not certify the amendments, the candidate needs to make the required changes in both copies to the satisfaction of the graduate coordinator of the school. When the graduate coordinator is satisfied with these amendments s/he notifies ARGS of the successful completion of the amendments.
ARGS sends the remaining thesis copy to the Library with a 'Library Release Authorisation' form. ARGS returns the originally submitted unbound copy of the thesis to the candidate.
The candidate has successfully completed the examination process. The ARGS will send the candidate a letter with your overall grade (you will not receive a mark, only a grade). For more information on the overall grade see section 8.2 under the heading ''Grades and Marks'.
Candidates can then download an 'Application to Graduate' form located at: www.monash.edu.au/graduations/apply.html
which should be completed and returned to Student Services. You are free to graduate at the next available Arts Graduation ceremony. You should inform your supervisor of your graduation date if possible. Once you have graduated, either in person or in absentia, you can use your degree and your postnominals.
Scenario B - One or Both Examiners Recommend Revise and Resubmit and/or an Adjudicator Recommends Revise and Resubmit
If one or both examiners recommend the candidate revise and resubmit the thesis, an Advisory Panel will be convened to decide on one of the following:
Appoint an external adjudicator
- Scenario B1
If the Advisory Panel decides that revise
and resubmit is the likely outcome of adjudication, the candidate
may be asked to revise and resubmit without going to adjudication
- Scenario B2
Thesis is sent to an adjudicator who recommends
revise and resubmit - Scenario B3
To read more about Advisory Panels see section 8.1 above, under the heading 'Advisory Panels':
Scenario B1 - One Examiner Recommends the Thesis Pass and the Other Examiner Recommends the Candidate Revise and Resubmit the Thesis - Appointment of Adjudicator
In these cases, an Advisory Panel will normally appoint an external adjudicator to decide on one or other of the examiners results. If an adjudicator is appointed, a letter will be sent from the ARGS inviting the candidate to respond to the examiners' comments within a stipulated timeframe. More information on Adjudication can be found in Section 8.1 above, under the heading 'Divergent Recommendations by Examiners'. The candidate, within the timeframe stipulated, either submits this response to ARGS or notifies ARGS that no response will be submitted.
The Adjudicator is sent the following:
- Candidate's response if one has been submitted
- Two anonymous 'Masters Thesis Examiners Reports'
- A copy of the thesis
- Instructions for adjudication
- A letter requesting the adjudicator to notify ARGS if they are unable to return the report within 6 weeks
ARGS sends a letter to the candidate informing of the adjudicator's name and that the thesis has been sent out for adjudication.
If the adjudicator's report is not received within the stipulated timeframe, ARGS sends a reminder letter to the adjudicator seeking advice on when the completion of the adjudication is likely.
Once ARGS receives the adjudicator's report, the Advisory Panel is re-convened to consider the adjudicator's recommendation.
The adjudicator cannot impose a new recommendation on the candidate but is asked to choose between the recommendations of the examiners. In the case of Scenario B1, an adjudicator may recommend the following:
Pass - Straight award (return to Scenario A1 above) OR
subject to completion of amendments (return to Scenario A2 above)
Revise and resubmit (see Scenario B2 below)
Scenario B2 - Both Examiners or an Advisory Panel Recommend Revise and Resubmit
If both examiners recommend that the candidate revise and resubmit the thesis, or if an Advisory Panel in the case of Scenario B1 decides that the likely outcome of adjudication is revise and resubmit, the candidate will be requested to re-enrol for a specified period to work on the revisions under supervision.
After the supervisor approves the revisions, the candidate submits two or three copies (ARGS will advise the candidate of the number of copies required) of the revised thesis in temporary binding to the ARGS as described above under the heading STAGE 1 - Submission.
ARGS returns the thesis to the dissenting examiner (or both examiners if both recommended revise and resubmit). The dissenting examiner(s) receive:
- One copy of the thesis
- One 'Masters Thesis Examiner's Report' form
- Instructions for examination
- A letter that requests the examiner(s) notify ARGS if they are unable to return the report within 6 weeks.
ARGS notifies the candidate that the thesis has been forwarded to the dissenting examiner(s) for re-examination.
If the reports are not received within the stipulated timeframe, ARGS sends a reminder letter to the dissenting examiner(s) seeking advice on when completion of the re-examination is likely.
ARGS receives the examiners' reports, which will recommend one of the following:
Pass - Straight Award (See Scenario A1 above)
- Pass - subject to completion of amendments (See Scenario A2 above)
and Resubmit (See Scenario B above: dependent on the outcome of examiners'
Fail (See Scenario C & D below)
PLEASE NOTE: Research candidates can revise and resubmit twice only.
Scenario B3 - Adjudicator Recommends Revise and Resubmit
If an Adjudicator recommends revise and resubmit, an Advisory Panel will be convened to decide on the timeframe for re-enrolment for the revisions, supervisory arrangements for the revision and who will examine the revised thesis - normally this will be the dissenting examiner and/or the Adjudicator who then becomes the second examiner. The candidate will be asked to re-enrol and discuss the best approach to revisions with the supervisor. After the supervisor approves the revisions, the candidate is required to submit the revised thesis as described above under the heading STAGE 1 -'Submission'. The Advisory Panel would have already determined the examiners and so the 'Nomination of Examiners' form is not required in this case.
The examiners will be asked to make a recommendation; all options are available to the examiners; see Stage 2 'Examination' above.
PLEASE NOTE: Research candidates can revise and resubmit twice only.
Scenario C - One Examiner Recommends Fail and One Examiner Recommends Revise and Resubmit or One Examiner Recommends Fail and One Examiner Recommends Pass.
The ARGS convenes an Advisory Panel and in most cases an Adjudicator will be appointed. To see the composition of an advisory panel see under Section 8.1.11 above.
The possible outcomes of adjudication when one examiner recommends FAIL and one examiner recommends REVISE AND RESUBMIT, can only be fail or revise and resubmit.
The possible outcomes of Adjudication when one examiner recommends the candidate FAIL the thesis and one examiner recommends the candidate PASS the thesis, can only be pass/pass subject to amendments or fail.
If the adjudicator recommends FAIL, see Scenario D below.
If the adjudicator recommends REVISE AND RESUBMIT, see Scenario B3 above.
If the adjudicator recommends PASS, see Scenario A above.
Scenario D - Both Examiners Recommend the Candidate Fail the Thesis
The ARGS convenes an Advisory Panel comprising the same members as described in Scenario B. The Advisory Panel recommends the degree not be awarded.
ARGS sends a letter to the candidate advising that the Masters thesis has failed the examination process and that the degree cannot be awarded, which means you are not permitted to use postnominals gained from a successful thesis examination.
The two copies of the thesis can be destroyed or returned to the candidate, but one copy must be kept in the Faculty for 25 years.
Only candidates who started prior to 2000 in an approved discipline can undertake a 75% thesis.


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Poor old Ned Stark, at least he lives on…in an undead sort of way.
More mash-ups by me, this time from AMC and Image's Walking Dead series and George RR Martin and HBO's The Game of Thrones.
For a larger image click below.
And if you are kind enough to purchase, don't forget to consider sending in a picture with you and the piece!
Sold Dec' 12
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For all your geek needs in design and t-shirts. I'm talking Star Wars, Walking Dead, Game of Thrones, Trek, Comics, Scifi, Zombies…you name it!
Humorous (at least to me) pieces or mash-ups using franchises I'm fond of as the central pieces and I continue to add classic comedy work, anything from Monty Python, Fawlty Towers to Extras and more.
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Curated Content RSS Feed
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Are You Ready to Deliver Personalized Learning?
by Ruth Kustoff, Kasper Spiro
3.10.14 | Learning Solutions Magazine | Feature
Training organizations are moving toward an ideal: personalized learning. However, there is little agreement about what "personalized learning" means. In this article, the authors examine what personalized learning is in the corporate environment, and how organizations can prepare to meet this new learning need.
76 Tips on Turning Instructional Design Challenges into Successes
contributing editor, Karen Forni
2.26.14 | Publications Library | Guild eBooks
Effectively addressing failures and mistakes in learning projects can strengthen relationships with customers and stakeholders and improve end results. This eBook provides 76 tips to help turn potential disaster into triumph.
The Role of Knowledge Management in Enabling Effective Performance at the Five Moments of Need
by Conrad Gottfredson, Bob Mosher
2.20.14 | Online Events Archive | Online Forums 2014
As learning professionals, the primary objective of our work should be enabling our learners' effective on-the-job performance at every changing moment. The only way we can accomplish . . .
2014 Global eLearning Salary & Compensation Report
2.19.14 | Research Library | Survey
Patti Shank explores trends in eLearning pay worldwide, looking at variables such as company size, number of people managed, and experience and providing a salary calculator to help readers figure baseline salaries.
Interface Design for Learning
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As designers of learning experiences, how much do we really know about how people learn? How do we design environments that support the cognitive and affective sides of learning, and how . . .
Five Keys for Flawless Virtual Training Implementation
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Designing a training program, training your trainers, and planning the schedule are hard enough. Wouldn't it be great if, once the program launched, it would magically unfold in perfect orde . . .
Best of Learning Solutions: Ideas You Can Play With
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We learn through playful discovery and experimentation; our brains make sense of the world through actions, interactions, and the resulting feedback loops. But are we designing truly . . .
Redesigning Learning Design to Meet Today's Challenges
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10.23.13 | Conference Archive | DevLearn 2013 Conference & Expo
Organizations today are dealing with new challenges and new requirements while also seeking greater opportunities for innovation. Therefore, it's time to consider the possibility th . . .
Performance Support: How to Make It Happen
by Marc Rosenberg, Steve Foreman
9.9.13 | Conference Archive | Performance Support Symposium 2013
Instead of just helping people learn what they need to know, why not go further and help people achieve what they need to do? While performance support was first introduced 22 years ago in . . .
At the Moment of Need: The Case for Performance Support
by Marc Rosenberg
6.6.13 | Publications Library | White papers
As jobs become more complex, workers not only need better and faster access to knowledge, they require direct performance support (PS). This white paper examines the business case for PS and how companies are making it work.
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HubSpot's Website Grader: Web Site Evaluator
This is truly an amazing tool. It "grades" your Web site using over 50 different variables, including your meta data, social networking efforts, conversion rates and much more.
The program can even perform a cross-analysis of your competitors' Web sites. The feedback and recommendations it provides are extremely insightful and can help any entrepreneur improve her small biz Web traffic.
-Jacalyn Barnes, SCORE
View more posts by Jacalyn
Hi Greg. Thanks for the comment. Glad you found it helpful. And, thanks for sharing the link on twitter. It's a good resource, especially for small biz owners who can't afford to hire optimization specialist. |
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This sounds like a very useful tool. I will check it out. Thanks for sharing. |


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Vietnam's swirling capital of Hanoi is populated by motorbikes swarming twisted streets and tree-lined boulevards. Shopping in Hanoi takes you among bicycle hawkers plying their goods while produce sellers balance vegetables like human scales and … More
Introducing Saigon – Vietnam's bustling city
Asia / Destinations / Food / InsiderHo Chi Minh City – or Saigon as locals will always call it – bristles with energy from its scooter-crushed streets to its confident 21st century skyscraper skyline. Packed between is an organised chaos of … More


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To find a doctor, call 800-667-5356 or click below:
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Some years ago, my older daughter lived in Seattle, and I was lucky enough to visit her several times. My two favorite things in that city were the dance steps embedded in the sidewalks at busy street crossing--presumably, you could lean to Cha-Cha while waiting for the light to change, and the fact that the giant laboring statue of "Working Man" was turned off every year for 24 hours on Labor Day. I have remembered that and tried to live my life accordingly.
This year, we are in Maine for a week, and we have just returned from a three hour hike, so I guess it's not entirely a work-free day, but here is the plan for the remaining hours: sit by the water with an appropriate beverage and read. Hope that your day is equally lovely


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The Beacon
Blog Tags: Sean Lesniak
Free Willy, Journals, and Saving Sharks: Q+A with Ocean Hero Youth Finalist Sean Lesniak
Sean Lesniak – Lowell, MA.
A lifelong shark lover, Sean, 8, convinced his state representative, David Nangle, to address the brutal practice of shark finning in Massachusetts. In response to Sean's request, Rep. Nangle filed a bill on his behalf to increase the fines and penalties on the practice of shark finning and Sean spoke on the bill's behalf before the state Legislature's Joint Judiciary Committee earlier this month. The bill, if passed, would impose fines or imprisonment on a statewide level in addition to already existing federal penalties for violators.


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Using the new dust test chamber for electronics
Nowadays, electrical and electronic products are placed in demanding
conditions, emphasising the need to protect them. Technical Research Centre of
Finland (VTT) has acquired a new dust test chamber for electronics enabling
the testing of equipment enclosures up to 2 metres high and 100 kg in weight
in normal operating position.
If electronics are placed in demanding operating conditions, they should be manufactured to endure such conditions or need to be protected accordingly. If equipment is placed outside, it should be designed according to temperature, rain, wind, dust and pollution conditions. This is usually reached by sealing the electronics in an enclosure or by preventing contaminants penetrating in the enclosures . The conditions in industrial facilities also set challenges for preventing fine particles, for example. Demanding conditions usually refer to difficult operating preconditions in relation to temperature and moisture, corrosion, vibration or electromagnetic features. Extreme conditions also require protection of electronics from their use condition.
Quick testing – shorter time to market
The new dust test chamber acquired by VTT enables the dust seal verification of whole equipment without separate test structures. This shortens the time to market for electronic products and increases company competitiveness. The testing laboratory owned by VTT is accredited for giving statements on the product enclosure classes.The manufacturers may use to present equipment in difficult conditions.
In addition to evaluating the dust sealing of different products, it is important to test the water tightness of the enclosure. This can be done with VTT's water testing devices.
Additional information
- Olavi Nevalainen
- Research Engineer
- +358 20 722 5642
VTT is an impartial expert organisation. Its objective is to develop new technologies, create new innovations and value added thus increasing customer's competencies. With its know how VTT produces research, development, testing and information services to public sector and companies as well as international organisations.


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Every week, we'll be letting you know about new releases the editors at O and Oprah.com couldn't stop reading. On sale today, the short story collection...
Blueprints for
Building Better Girls By Elissa Schappell Elissa Schappell is not for the fainthearted. In this
collection of eight revelatory, risky stories, we meet the girls that all
mothers fear their daughter might become—or, to varying degrees, the girls we
might have become ourselves. One turns to hate to cover her vulnerability,
while another suffers from an eating disorder, in some part due to her mother's all-consuming embrace. The most shocking story follows a college coed through
her days of binge drinking and blacking out during a relentless parade of frat
house parties. Surprisingly, it's also the most moving. Schappell has the ability—and the
guts—to cut straight through the "girls gone wild" images that inevitably throb to mind (ouch) and show us the tender and often hopeful human beings that live inside these women-to-be. In one upsetting scene, a group of angry, male bar patrons chases the coed and her friends across a deserted parking lot. As she jumps into a car to escape, the coed feels her mother's treasured strand of pearls break and must leave those pearls rolling hopelessly across the asphalt—save for one, about which she wonders if she has any right to even keep. "Maybe some farm kid walking down the street would find it..." she says. "And then they'd think that maybe the world wasn't as ugly as they thought it was. Maybe there was magic in it after all." A rule for us all: There is always magic in a gift from your mother. Always. 1. You probably can say it in 140 characters.
2. If you already know it's going to make you angry, don't click. 3. There's a Tumblr for that. 4. Even though I haven't met all of my Facebook friends, I love that they always remember my birthday. 5. If all else fails, watch Marcel the Shell With Shoes On. MARCEL THE SHELL WITH SHOES ON from Dean Fleischer-Camp on Vimeo.
This new report backs up previous studies by financial scholars as well as from financial institutions, all of which suggested that female investors were less prone to the overconfidence that can lead to big financial losses (and, less happily, whopping financial gains). Since these two articles have already gotten the ball rolling, we'd like to point out a few more ways that women have an edge. We're not saying we're better than men; we're just taking a moment to celebrate our gender's advantages.
It isn't an herb, technically, but no matter. "Arugula has oomph, because it has that wonderful meaty, peppery flavor. That, combined with nuts, is just superb," McVicar says. The essential ingredient in McVicar's arugula pesto is lemon—the combination of the juice and zest's zing with the almost spicy arugula "is just magic," McVicar says. She serves arugula pesto on pasta, as a dip with chips—or, even better, on a cold potato salad. And if you're just hooked on basil pesto, seek out Mrs. Burns' Lemon Basil, an heirloom variety that makes a very citrusy pesto. [Get the simple recipe, after the jump]
Salt water taffy is, alas, not made with salt water, but good ol' sugar and corn syrup. Despite the simple ingredient list (it also contains sea salt and flavorings), I still would not attempt making it myself--especially after watching this video of a Maine candy shop's impressively powerful 100-year-old machines in action. New York confectioner Marisa Wu, however, is undeterred by the upper body strength required to twist and pull salt water taffy by hand. Her fancy-flavored salt water taffy (think coconut, hibiscus and black cherry) are just hitting stores now. Until they reach your neighborhood, you can order them through Brooklyn's Bedford Cheese Shop, which will ship anywhere, allowing you to combine your childhood memories with your adult palate--no matter where you are.
If you have a question, send it to us! Q: Can I cheat on my diet on the weekends? A: We asked Janis Jibrin, MS, RD, Best Life lead nutritionist and diet counselor, to answer this question. She says she's heard this a lot lately—and she gave us four reasons to rethink this as a weight loss plan. Some weekend cheaters gained almost 9 pounds in a year. Your body doesn't know the difference between weekdays and weekends. If you splurge on the lumberjack breakfast or a plate of beignets, that could have three times the calories of your ordinary oatmeal breakfast. A 2008 study published in the journal Obesity found that participants who were likely to increase their calories on Saturday and decrease their activity on Sunday racked up tiny weight gains that led to almost 9 pounds at the end of a year.
"I owe my mother a lot, " the writer says. "Besides the fact that she took care of us as a single mother, she also had to help me through an accident I had when I was 10 years old, which involved a number of surgeries; she made sure we were housed and fed, and she pushed us to get educations. ... My problem is that I have such a hard time visiting her. All she wants is someone to sit with her, but that is hard for me. I take my son with me sometimes, and it is wonderful to see her face light up. She doesn't say much, but we just sit for a while and then leave. I wish I could go there and spend more time, but it is really hard to do that. It literally drains me of all of my energy. I'm not complaining about her. She makes no demands. I'm not the dying person. I feel I should want to go see her as much as possible now." While Tennis responds in a loving, thoughtful manner to the writer's confusions, what struck us most was the mother—and the idea that to sit and be with somebody sick is enough. So often we visitors worry about flowers (is pollen allowed?); we worry about bringing balloons or tabloid magazines; we worry about whether to sit on the bed (too close?) or sit on the chair (too far); we worry we're talking about silly, selfish things (our broken dishwasher, our jerky ex) when these sick people are struggling for their lives. However, instead of doing all this worrying, which may just lead you not to show up in the hospital room at all, or to panic and act in the least way you'd like to act, you can just sit and be there. Being there is enough. Read more: Ways to help an ailing friend or parent Men! What are they thinking? We can't always answer that, but we'll be posting our favorite glimpses into their world in this space every Thursday.
* It was nice to learn what the real Ernest Hemingway looked like in a swimsuit after completely falling for Corey Stoll's hilarious yet smoldering portrayal of the lion-wrestling, hard-drinking ultra-macho writer in the utterly charming Midnight in Paris (go see it this weekend!). * Having received two heart transplants, 31-year-old Erik Compton knows "golf is not that big of a deal," but that only makes the fact that he won the Mexico open and qualified for the PGA tour that much more impressive. [PGA Tour] * We spent some time this week cataloging the unique advantages of being a woman. A male cheerleader whose Bring It On-worthy performance has gone viral reminds us that anyone striving to make us forget our differences is worth celebrating too. [Towleroad] * Surely you will be shocked to learn that men don't visit McDonald's for the salads. Still though, this infographic of guys' fast-food habits has plenty of fun facts—like how many hot sauce packets the average guy has squirreled away at home. [Mashable] * "We were united, we were strong, we were righteous, we were unmovable, we were funny, we were corny as hell and as serious as death itself...Together, we told an older, richer story about the possibilities of friendship that transcended those I'd written in my songs and in my music. Clarence carried it in his heart."—Bruce Springsteen remembers Clarence Clemmons A bottle of beer can be a thing of beauty—just ask Homer Simpson. Class up your next barbecue with one of these five options.
Bohemia Frida Kahlo A Mexican beer pays homage to the iconic artist with a limited edition bottle featuring Kahlo's face and designs that appear in much of her work: flowers, hummingbirds and monkeys. Cantillon Rosé de Gambrinus The label on this Belgian ale walks a fine line between racy and sophisticated. And the pink, raspberry-based beer inside is lovely. [Next, three more beers that belong at your barbecue] Advertisement
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Vitamin D Identified as Possible Breast Cancer Treatment
Research suggests potential therapy for triple-negative disease (Jan. 22)
In a study published in the Journal of Cell Biology, researchers at Saint Louis University in St. Louis, Missouri, have discovered a molecular pathway that contributes to triple-negative breast cancer, an often deadly and treatment-resistant form of cancer that tends to strike younger women. In addition, the researchers identified vitamin D as a possible new therapy.Women who are born with BRCA1 gene mutations are at increased risk for developing breast and ovarian cancers within their lifetime, and the tumors that arise are often the triple-negative type. Although chemotherapy is the most effective treatment for triple-negative breast cancer, it has profound secondary effects.
BRCA1 is important because it is involved in repairing DNA double-strand breaks, a kind of DNA damage that is especially dangerous for the integrity of the genome (the body's hereditary information). BRCA1 also is involved in control mechanisms during cell proliferation that make sure the DNA information has been accurately replicated and transferred to the daughter cells. Thus, BRCA1 is considered a safeguard of the genome.
Loss of BRCA1 is bad news for the information contained in a cell's genetic blueprint. It results in genomic instability, characterized by unrepaired DNA breaks and chromosomal aberrations that compromise cell viability.
How BRCA1-mutated cells are able to form tumors has been a long-standing question. Investigators recently showed that loss of another DNA repair factor, 53BP1, allows proliferation and survival of BRCA1-deficient cells. In addition, decreased levels of 53BP1 were observed in triple-negative breast cancers, and correlated with resistance to drugs at the forefront of cancer treatment, such as poly ADP ribose polymerase (PARP) inhibitors.
The researchers identified a pathway responsible for the loss of 53BP1 in breast cancers with poor prognosis, specifically BRCA1-mutated and triple-negative cancers. It turned out that loss of BRCA1 increases the expression of a protease, cathepsin L, which causes the degradation of 53BP1. Cells that have lost both BRCA1 and 53BP1 have the ability to repair DNA, to maintain the integrity of the genome, and to proliferate. Thus, the protease helps cells with faulty BRCA1 to survive.
The researchers also found that treatment of BRCA1-deficient tumor cells with vitamin D restores high levels of 53BP1, which results in increased genomic instability and reduced proliferation. Importantly, their evidence suggests that vitamin D treatment might restore sensitivity to PARP inhibitors in patients who become resistant. Thus, a combination of vitamin D and PARP inhibitors could represent a novel therapeutic strategy for breast cancers with poor prognosis, the researchers say.
Source: Saint Louis University; January 22, 2013.
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Events for May 15, 2013
Abstract Generation: Now in Print
When: From 02/13/2013 to 06/24/2013
Impressionism, Fashion, and Modernity
When: From 02/26/2013 to 05/27/2013
Photography and the American Civil War
When: From 04/02/2013 to 09/02/2013
Punk: Chaos to Couture
When: From 05/09/2013 to 08/14/2013
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Concierge Corner with Eric: General Assembly Restaurant Recently opened restaur...Read More
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The @DominiqueAnsel bakery came out with a chocolate cookie shot served with ice cold milk. Who wants one right now? http://t.co/T53vSqZQFkRead More
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Trump SoHo® New York Virtual TourRead More