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A dependable and sturdy work truck with excellent towing capacity.
Reviewed by Automotive on 7/16/2007
The Chevrolet Silverado is a full-size pickup truck that was introduced in 1998. It is Chevrolet's flagship full-size truck, and it has a plethora of models available for each model year spanning several generations. There are over thirty Silverado base models to choose from for 2007. Within each trim level are the 4x2 or 4x4 models; the regular cab, crew cab, or extended cab models; and then different box lengths within each of these sub groups.
The 2007 Silverado receives a few exterior changes for a more rugged and athletic look. It gets a bigger cabin with higher quality materials. It also gets an increase in gas mileage and the maximum towing capacity goes up.
The Silverado receives some cosmetic changes for the 2007 lineup, replacing the previous headlights with more traditional stacked headlights. These surround a larger grille on a front end that has been squared off. The windshield is at a smaller angle, increasing overall aerodynamics. The available trims include the Work Truck, LT1, LT2, and LTZ, plus there is a Z71 off-road package available. All wheels range from 17 to 20 inches. Bed lengths are five feet and eight inches, six feet and six inches, and eight feet even. These sizes are available with a cab style, but not with every powertrain.
The 2007 Silverado's interior is high-quality—no more low-quality plastics. The LTZ receives the most refinement in this area. The control clusters are still simple and conveniently placed. However, the audio and air systems are a bit small. The front seats are now roomier, and the Silverado has more storage space than past models. The crew cab models have more legroom in the back and split rear seats, which can be raised for more storage space.
The 2007 Silverado's base engine is a 4.3-liter V-6. The midrange 5.3-liter, 315-hp V-8 is available as a regular gas engine or a flex-fuel engine, and the 367-hp, six-liter V-8 increases maximum towing capacity to 10500 pounds. All models run on a simple but solid four-speed automatic transmission. Outside of the powertrain, some changes include a switch to coil springs for the front suspension, and the switch to the simpler and more precise rack-and-pinion steering.
The Silverado handles well. The smaller models do surprisingly well in urban settings but are still powerful enough for smaller workloads. In terms of gas consumption, the larger options, of course, present a problem in heavier traffic.
All 2007 Silverado models get anti-lock brakes standard. The crew cab models have an electronic stability system standard, and this is also optional on the extended cabs. All models have required airbags standard and optional side curtain airbags. The front seatbelts have pretensioners. OnStar also come standard.


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Jan 31, 2013, 10:30 AM | #1 |
2 Qs about my new 27" imac
So I got my new imac and digging it so far, but when i put it to sleep, there is no indication that it is so it appears to be turned off. PLEASE tell me there's suppose to be a blinking light for sleep... 2: If i use migration from my Macbook Pro, will it allow me to select only specific applications and/or files? |
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Jan 31, 2013, 10:40 AM | #2 | |
Yes. |
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Jan 31, 2013, 04:22 PM | #3 |
Good to know about migration.
But a real bummer about iMacs not having a sleep light :shakehead: |
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Jan 31, 2013, 04:50 PM | #4 |
I know plenty of people with iMacs in bedrooms (think students) and the blinking light can be a real pain. I once had to put a thick black rubber sticker over the light on an old iMac for just that reason. My in-laws have theirs in a guest bedroom, that gets use when everyone is in town. It can be very disruptive to those sensitive to light. I'm glad they did away with it. Why do you need to have a blinking light? Much less useful than say an internal optical drive.
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Jan 31, 2013, 08:55 PM | #5 | |
It doesnt have to be very bright. The camera green light could potentially serve this purpose w/ an option to turn it off for those sensitive to light. Omitting it all together is ridiculous imo |
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Jan 31, 2013, 09:55 PM | #6 | |
I use my imac in my bedroom and certainly don't need a light on it. What was the last imac to have a sleep lamp? My 2008 didn't have one.
G3 450 B&W, K-Lime iBook G3/466SE, PB G4 867(Ti), G4 800 DP(QS), PB G4 1.5 17 (Al), iPT 1G, 08 24 iMac, MBP 09 17, iP3Gs, iPad1&2, iP4s, '12 27 iMac, iP5s, rMBP(H) 15", Air. |
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Feb 1, 2013, 02:26 PM | #7 | ||
There never was an option to disable it. I kind of doubt Apple would spend the money to put in a relatively useless part, then more money to have someone write code to turn off the useless part. Trying to double duty the camera indicator light could cause all kinds of issues, such as making people think the camera is on (real smart for those changing clothes in their bedroom) or open it up to security flaws where hackers might have an easier time turning the light off while the camera is on. Again, camera on without your knowledge. Quote:
Last edited by bflowers; Feb 1, 2013 at 02:43 PM. |
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Feb 1, 2013, 02:36 PM | #8 |
HOGWASH to answer #2, when you use Setup Assistant or Migration you can only select all Data, all Apps, all Settings, etc... you cannot specify individual file or folders!
27" iMac i5, 24 GB RAM; MBA 11.6" 1.4GHz 4GB RAM 128GB SSD; Multiple HP Printers; Lacie Quadra D2 external HDs; 4S iPhone; Nikon DLSR |
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Feb 1, 2013, 02:48 PM | #9 | |
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Bleu du Bocage
As this cheese ages the goat milk mellows while the blue veining intensifies. You get a spicy but lightly sweet and acidic blue that is buttery and smooth in texture. Read More -
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Roquefort Papillon Black Label
The French have named this assertive, spicy sheep their 'King of Blues' and showed their loyalty by crowning it with the first AOC designation in 1925. They have since embraced democracy, but 'President of Blue' doesn't have the same ring. Read More -
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Blanc Bleu Tambour
Don't be fooled by the name. The bleu here refers to the mold that grows on the rind. The paste itself is a sparkling white, and the raw goats milk imparts a clean, but complex flavor. Pair with a crisp Chablis. Read More -
Cave Aged
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Fourme d'Ambert
This cheese is in rare Fourme. Time in our caves yields a sweet, super-creamy bite that will convert even the staunchest blue cheese hater. Read More -
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Bleu d'Auvergne
A medium-strength, versatile blue we think of as Roquefort's nemesis. Made in a similar style, but with raw cow's milk, the sliceable paste is mellow and meaty with the perfect balance of salt and spice. Read More


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Product Recall: One SKU of Velveeta Cheesy Skillet Singles Due to Undeclared Soy: Click Here
PLACE syrup and butter in large skillet. Bring to boil on medium heat. Reduce heat to low; simmer 2 min.
ADD sweet potatoes. Cook 10 min., stirring occasionally to evenly coat potatoes with glaze.
SPRINKLE with pecans.


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Georgia-Pacific and OIT Host Pump and Steam System Training
October 9, 2001
OIT's Forest Products and BestPractices teams have been working with Georgia-Pacific Corp. to hold corporate training in pump and steam systems. On Sept. 25-27, OIT and Georgia-Pacific held pump and steam systems training for staff of six mills in the Pacific Northwest at the Toledo, OR, mill. In support of the training, OIT's BestPractices' experts performed collaborative targeted assessments (CTAs) with Georgia-Pacific staff. The steam CTA was held September 18-21 at the Toledo, OR, mill and the pump system assessment took place at the Wauna, OR, mill September 17-20.


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1. The kit includes the Screamin' Eagle billet cam plate which is precision machined from 6061 aluminum and anodized for durability, the high volume oil pump, hydraulic cam chain tensioners, bearing retainer plate and chain guide riser, along with six different sized shaft bearings.
2. To get started the rocker boxes, rocker assembly, and the pushrods were removed.
3. Next, the cam cover was removed to gain access to the camshaft sprocket and chain. Once removed, Brian then unbolted the cam plate and pulled both the plate and the oil pump as one piece.
4. Once everything was out Brian inspected the main- shaft for any wear or discoloring, then did the same for the two cam bearings. This set was like new and did not need to be changed. Also all the oil ports and passages were inspected and everything checked out fine.
5. Here you can see the difference between the two pumps. First, the shape of the feed rotors on the newer pump, the cogs are rounder and the opening to the rotor is bigger for more oil (red arrow). Also, the flow port is bigger (yellow arrow) so more oil flows through. And with the new billet plate and improved design for a perfect fit you will notice there is no need for the inner O-ring, like on the old pump(blue arrow).
6. Next, Brian removed the cams from the stock cam plate with the help of a press.
7. The second part of this upgrade is the hydraulic cam chain tensioner; here is a look at the spring style with the load pin in place. The pin is used to unload the tension from the cam chain so that the cams can be removed.
8. Here are the new hydraulic cam chain tensioners, you can see there are no springs. How they work is as the motor builds up the oil pressure, oil is also pushed into the passages of the tensioners (arrows), pushing and holding the wear pads to the cam chain.
9. Next, the cams and chain were lined up with the timing marks then installed along with new bearings into the new billet cam plate.
10. This is where the inner hydraulic cam chain tensioners mount to the plate and how the oil flow ports lineup (arrows).
11. Here is how it will mount and the pad will hold tension on the chain.
12. Brian installed a new oil seal O-ring into the oil port of the case, then installed the new style oil pump
13. ...followed by the new billet cam support plate.
14. Once the plate was torqued to 90 in-lb Brian needed to install the camshaft sprockets. With a small straight edge and a set of feeler gauges he was able to determine that 0.357 spacer was needed to ensure that both sprockets were aligned.
15. Then the camshaft drive sprockets, the primary drive chain, and the outer hydraulic chain tensioners were installed.
16. Wrapping up this install Brian reinstalled the pushrods, the rocker assembly, lifters, and the rocker boxes. Once the lifters had time to bleed down Brian adjusted the pushrods to factory spec.
17. Lastly the cam cover and the exhaust was reinstalled. The bike was wiped down then taken out for a test run. As soon as the bike started up it was easy to see that there was a difference in the motor. The idle seemed smoother but the oil pressure at idle was up 10 PSI at cold start up. This is what we found after testing the bike.
Not that we need to point out how lucky we are at HOT BIKE, but we are very fortunate to get our hands on some of the newest and coolest things out there in V-Twin land. We still get excited when a box of new parts shows up on our doorstep. But, our favorite part of receiving these cool parts is bolting them onto a bike for you to check out.
For example, we received this Screamin' Eagle Hydraulic Cam Chain Tensioner Plate Upgrade Kit from Harley-Davidson. This kit updates the cam chain tensioner of your early-model Twin Cam engine to the latest design, as featured on the Twin Cam 96ci engine. The billet cam support plate has been designed to allow the installation of the late-model hydraulic cam chain tensioners to early Twin Cam-equipped models with the use of your existing cams, and is pre-assembled with crankshaft bushing and an oil pressure relief valve. The hydraulic cam chain tensioners will significantly outlast the spring-loaded tensioners, and are an ideal addition to an engine modified for improved performance. In addition, if needed the '02-06 models feature the late model single row front cam chain and sprockets ('99-01 models use the existing front silent chain). The kit includes the improved late-model oil pump that increases flow by 8 percent and scavenging by 22 percent for better cooling. This improves the stock oiling system to increase oil flow to piston oil jets, cam chain tensioners, pinion shaft bearings and connecting rod bearings
The kit fits '99-06 Touring, '00-06 Softail and '99-05 Dyna models, and retails for $429.95. We installed the kit on a '01 Ultra Classic with a little over 25,000 miles. The owner Brian happens to be a Harley tech and was glad to let us use his bike for the install.
Before the install | After the install | |
Cold idle | 30psi | 40psi |
Warm idle | 18psi | 32psi |
Cold at 2750 rpm | 32psi | 50psi |
Warm at 2750 rpm | 30psi | 42psi |


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A-Ha's Take On Me, The Literal Version
Even after 23 years, A-Ha's Take on Me music video remains one of the best ever made. And, in late celebration, somebody went and made a literal translation of it, complete with subtitles. Definitely worth a viewing. I love the "this guy's gonna get an ass full of pipe wrench" at the 2:33 mark. Awesome. I wish I could climb in and out of drawings. Because then I'd, well, draw myself a big-breasted lady friend. Yeah, with no mouth. Wait, need a mouth. Okay, no teeth. Oh shit, or voice box.
Thanks to Bill, who claims to have crawled into a comic book and had sex with Catwoman.
This is the video for Daft's Punk's first single, 'Derezzed', off the TRON: Legacy soundtrack. It's pretty badass. The song too. Almost enough to make me forget Disney is behind the whole production. Almost. But like another famous mouse once told me, "Here I come to save ... / Continue →
Apparently the most recent winner of X-Factor (Britain's American Idol) is notorious for taking the #1 Christmas song spot on the charts. But this year, thanks to massive online campaigns on Twitter and Facebook created by Jon Morter, Rage Against the Machine's 17-year old cla... / Continue →
Remember the video of the Muppets performing Queen's 'Bohemian Rhapsody' from a few weeks ago? Well those crazy hand-up-their ass plushies are back at it, this time with the holiday classic 'Ringing of the Bells'. And speaking of ringing bells: There was a fugitive who sough... / Continue →


text: Gaius Petrius Ruso has just arrived for duty in the Britain, a far backwater of the Roman Empire. He's been assigned to the Valeria Victrix Legion as Medicus, serving the legion and the natives living in the town surrounding the barracks. When the only other doctor on staff is poisoned by a plate of oysters at the local bar/bordello, Ruso works on alone. Tramping the town in an exhausted stupor, he encounters an odious merchant beating an unconscious slave girl—who clearly has a badly broken arm.


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Birth Control Permanent Methods (cont.) Medical Author:
Omnia M Samra, MD
Medical Editor:
Melissa Conrad Stöppler, MD, Chief Medical Editor
Melissa Conrad Stöppler, MD, Chief Medical EditorMelissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology. IN THIS ARTICLESynonyms and Keywordscontraception, impregnation, pregnancy, preventing pregnancy, sterilization, tubal ligation, tubal sterilization, tubes tied, vasectomy, Essure, Fallopian tubes, birth control overview, birth control permanent methods Next Page: Must Read Articles Related to Birth Control Permanent Methods
Birth Control FAQs
The practice of birth control is as old as human existence. Your choice of birth control method involves factors such as how easy it is to use, safety, risks, c...learn more >>
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The practice of birth control is as old as human existence. Today, the voluntary control of fertility is of paramount importance to modern society.learn more >>
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Contraception »
The practice of contraception is as old as human existence.


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By tlc (Council Bluffs, Iowa) on Feb 13, 2013
Comments: Been pleased with NordicTrack since it showed up at the door. Very helpful truckers. Easy to assemble, just a couple hours. Got started using the Audiostrider the day after it arrived. Now into a regular routine of three days on, one off. Thirty minutes each time. Should be in great shape by summer.
See better, faster results with incline training on the AudioStrider 990 Pro elliptical. A Power Incline Ramp™ adjusts from 15 to 40 degrees with 1-Touch™ controls to increase intensity, decrease stress on joints and target lower body muscle groups. A tech-driven console supports a low-impact cardio workout with a two-speed fan and advanced sound system. Built with 24 digital resistance levels and 30 workout apps, this elliptical has been a consumer magazine Best Buy for four years in a row.


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2:49 PM PST, December 28, 2012
Advertisement |
Editor's note: As we usher out 2012 and welcome 2013, The Herald-Mail has prepared a package of year-end stories that provide short recaps of some of the top stories of the year past.
These stories will be published each day through New Year's Day.
Funny money
January 16 — In mid-January, local police started receiving reports of counterfeit money showing up at local businesses, a problem that would persist for months.
The fake bills were passed at restaurants and convenience stores.
Counterfeit bills also showed up when people tried to sell merchandise on their own.
One case stemmed from an incident Jan. 15 in which a woman sold a Sony PSP and 11 games to a person in a parking lot, according to court records.
The woman said a man stepped from a silver sport utility vehicle and handed her a $100 bill and three $20s.
The woman said she attempted to use the $160 at a local store and was told by store workers that the currency was "non-genuine," the records said.
Police at one point during the year arrested two men in connection with counterfeit bills but investigators said the men were not connected to all the fake money being used in the county.
The men were arrested after police searched a city home on March 1 at 738 Summit Ave., where the two lived, and found a trash can containing sheets of paper with printed images of currency, according to court records.
— Dave McMillion
City shootings
Jan. 23-24 — Hagerstown police investigated two shootings on two consecutive days. They said they did not believe the shootings were connected.
The first shooting was reported at about 3:30 p.m. on Jan. 23 at the intersection of Cannon Avenue and North Mulberry Street near Fairgrounds Park. Police found a man with several gunshot wounds, including one to the torso.
The next day, a wounded man was found on Jonathan Street. That shooting was reported shortly after 1 a.m. on Jan. 24 in the 300 block of North Jonathan Street. Officers who responded found a man in front of an apartment building with a gunshot wound to his head.
Capt. Mark Holtzman said at the time that both victims were taken to Meritus Medical Center east of Hagerstown.
The victim of the first shooting survived.
The victim of the second shooting, Christopher Lee Follett, 29, of New York City, died Jan. 26.
Police charged Juan Sylvester Barnes, 28, of no fixed address, in the Follett shooting. Barnes was charged with one count each of attempted second-degree murder, first-degree assault, second-degree assault, reckless endangerment, handgun use during a crime of violence and felon in possession of a handgun.
Barnes was sentenced to serve 65 years in prison.
— Dan Dearth
Sneaker flap
Feb. 4 — Valley Mall was locked down and temporarily evacuated after more people became unruly while they were waiting to buy a new Nike sneaker at the Foot Locker shoe store.
About 15 officers from the sheriff's office, Maryland State Police and Hagerstown Police Department responded to the store at 8:10 a.m. after they were notified that about 100 people had created a disturbance while waiting in front of the Foot Locker for the release of the new Nike Foam sneaker.
When officers arrived, they discovered that 100 to 150 people were involved.
"Apparently, a lot of people had been waiting a long time and people started butting in line," Washington County Sheriff Douglas Mullendore said at the time.
Police said some people told them they had been in line waiting to buy the shoes since 7:30 the night before.
Mullendore said that after the mall was evacuated and locked down, patrons who were waiting to buy the shoes were escorted into the store a few at a time.
No arrests were made.
— Dan Dearth
MCI disturbances
Feb. 24 — Two disturbances in one night at the Maryland Correctional Institution south of Hagerstown led to disciplinary action against four correctional officers and the transfer of some inmates.
The disturbances occurred Feb. 18, with the first "a minor assault on (an) officer" in a segregation unit, Rick Binetti, a spokesman for the Maryland Department of Public Safety and Correctional Services, said at the time.
Binetti said the second disturbance "began when a large group of inmates in a locked recreation hall became disruptive and refused to comply with officers' orders."
Some inmates "did throw liquids and/or other items," he said.
Officers who responded to the recreation hall — a common area on a tier — used "nonlethal weaponry" to quell the disturbance, he said.
A source who asked not to be named said correctional officers broke out windows and used tear gas and rubber bullets.
Binetti would not describe what officers used to subdue the inmates, but said "staff did break windows."
He said no staff members were seriously injured.
— Dan Dearth
Cold case acquittal
April 19, 2008- Feb. 24, 2012 — Almost four years elapsed between the 2008 murder of Carol Marie Brown and the trial of the man Hagerstown police charged with killing the 22-year-old mother of two in her Mitchell Avenue home.
When the case against 44-year-old Darrol Sands finally went before a Washington County Circuit Court jury, jurors deliberated almost eight hours over two days before finding him not guilty of first-degree murder and all other counts on Feb. 24.
The verdict did not free Sands, who was serving an unrelated drug-trafficking sentence stemming from an arrest two years after Brown's murder.
Brown was found dead in the bathtub on the night of April 19, 2008. A medical examiner attributed death to stabbing and strangulation. Sands' palm print was found on the edge of the tub and his DNA was found both in Brown's body and her bedroom, according to evidence presented at trial.
Brown's body was discovered by her mother. Sands and another man rushed into the house and both went into the bathroom after hearing screams from the mother, according to trial testimony.
Sands, who lived across the street from Brown, testified he had sex with Brown the night before her body was found. He explained the palm print on the bathtub as possibly having been left when he and the other man ran into the bathroom.
Defense attorney James J. Podlas presented witnesses who testified that a number of other people could have been involved in Brown's death, including a trio of men from Martinsburg, W.Va.
— Don Aines
Meth lab charges
Feb. 6-July — A Clear Spring man who had been a fugitive since being charged in warrants in February with operating a methamphetamine lab at his home was captured in March during a routine traffic stop in Hancock.
Bryan Michael Davis, 25, of 39 S. Martin St., had been sought by law enforcement officers since Feb. 6, when agents from the Washington County Narcotics Task Force and the U.S. Drug Enforcement Administration raided the house he shared with family members.
Police said they found numerous items in Davis' upstairs bedroom that were used to manufacture methamphetamine, including Coleman fuel, drain cleaner, syringes, coffee filters, plastic tubing, blister packs containing pills, digital scales and packaging materials.
He subsequently was charged with one count each of manufacturing a controlled dangerous substance, possession of a controlled dangerous substance, possession of controlled dangerous substance paraphernalia, possession of controlled paraphernalia, possession of narcotic production equipment and maintaining a common nuisance.
Davis was riding in the back seat of a black Acura when Hancock police pulled over the vehicle because another passenger wasn't wearing a seat belt, officers said at the time.
Davis was sentenced in July to serve four years in prison, according to court records.
— Dan Dearth
Chief Smith announces retirement plan
March 21 — Hagerstown Police Chief Arthur Smith, who made fighting Hagerstown's drug problem one of his top priorities, announced he would retire Sept. 6 after 12 years of service with the city.
"It's just time," Smith said when asked why he planned to retire. "I want to give someone else a chance."
Before coming to Hagerstown in 1999, Smith served with the Baltimore Police Department, where he rose to the rank of major and retired after 26 years.
Smith, 61, replaced former police Chief Dale Jones, who resigned to head the law-enforcement branch of the National Marine Fisheries Service.
At the time of his appointment as chief, Smith said he was aware of Hagerstown's continuing problem with an open-air drug market and considered suppressing it a challenge.
Smith had a different education than most officers.
He said he received a bachelor of arts degree in mathematics from American University in 1973 and a master of science in economics from the University of Baltimore.
He also attended the Senior Management Institute for Police at Harvard University's Kennedy School of Government.
From 2005-06, Smith took an unpaid leave of absence from the city and worked under contract for the U.S. State Department in Afghanistan, where he served as an adviser to a provincial police chief in the southern part of that country.
Capt. Mark Holtzman has served as acting police chief since Smith retired.
— Dan Dearth
State police barrack
April 30 — Washington County got a new $11.3 million Maryland State Police barrack in 2012, a facility that replaced one built in 1973 and was designed to meet the agency's law enforcement needs for years to come, officials with the department said.
The Maryland State Police Western Operations Center on Col. Henry K. Douglas Drive off Sharpsburg Pike gives state police in the Hagerstown barrack their first fingerprint center and a crime lab that has six times more space than an old lab.
Security measures in the facility include a five-layer checkpoint system that one must pass through to reach the building's crime lab and surveillance cameras inside a drug evidence room that can be monitored at Maryland State Police headquarters in Pikesville, Md.
State police troopers work out of the first floor of the building, which includes a flexible dispatching area that can be transformed into a central command center in case of a large-scale emergency in the area, said Lt. Thomas Woodward.
The building has dorm space that can accommodate up to seven people. There was dorm space in the old barrack but that was lost to install a "very small crime lab," Woodward said.
— Dave McMillion
Precious metals targeted
May through November 2012 — The problem of precious metal thefts continued to make headlines in 2012 when grave sites were targeted and people were charged with stealing metal from an electric substation and from a former Hagerstown furniture factory.
Police over the last two years have been dealing with theft of metals such as copper pipe, some of which was stolen from homes up for sale or in foreclosure.
Scrap metal processors said they were aware of the problem and had set up systems to help prevent the thefts, like setting aside suspicious loads of metal brought into their facilities so police can examine them.
Police have said that just about any metal object is susceptible to begin taken, from heat pumps to catalytic converters, manhole covers, air conditioners and grates from car washes.
A Pennsylvania man was charged in November with stealing more than $40,000 worth of bronze vases from Rest Haven Cemetery on Pennsylvania Avenue.
Some of the vases were recovered, but not all could be traced to the owners, said Rest Haven Cemetery President Charles Brown.
On Nov. 1, a Hagerstown man was sentenced to 23 years in state prison after a Washington County Circuit jury found him guilty of stealing copper and other metals from a vacant furniture business.
Ronnie Eugene Domer, 41, formerly of 277 S. Potomac St., Apt. 3, was convicted of second-degree burglary, theft and malicious destruction of property.
During a two-day trial there was testimony that Domer and accomplices used walkie-talkies to communicate and look out for police during an Oct. 12, 2011, burglary at the former Statton Furniture building on East First Street, Assistant State's Attorney Michele Hansen said.
Damage to the building totaled about $100,000 and police believed it had been burglarized more than once.
In May, Michael Steven Bray of Smithsburg was given a three-year suspended sentence and ordered to pay $1,000 in restitution in connection with the theft of 200 pounds of copper wire from a Potomac Edison substation at Maryland 64 and Bikle Road in Smithsburg.
The wires were used to ground the facility and a Potomac Edison Co. spokesman said such a theft poses a threat of electrocution.
Authorities in West Virginia said in October that four people had been charged in the theft of more than 400 pounds of copper wire from multiple electrical power substations in Berkeley County since August.
— Dave McMillion
Graveyard vandalized
Oct. 1 — The tombstones of an infant and World War II veterans were among about a dozen grave markers that were vandalized recently at the cemetery across the street from Manor Church of the Brethren near Boonsboro.
Pastor Joy Zepp said at the time that she received a call on the morning of Oct. 1 notifying her that vandals had pushed over the headstones.
"I'm disgusted," she said during an October interview. "I don't understand why people have to destroy other people's property."
About 12 tombstones, including those marking the graves of World War II veterans and an infant who died in 1918, were lying on the rain-soaked ground. Some of the markers were so old that the lettering had worn away over time.
Cemetery caretaker Heather Gossard said the cemetery dates to the 18th century. She said the graveyard no longer belongs to the church, but is owned by a mixture of church members and others who bought shares in the property.
She said a member of the congregation discovered the vandalism, which is believed to have happened between Sept. 26 and Sept. 30.
Most of the headstones that were damaged had been pushed over. But the grave marker of the infant was broken in half.
Washington County Sheriff's Office spokeswoman Carly Hose said no one had been apprehended as of Dec. 20.
— Dan Dearth
Death penalty
Nov. 11, 2010-Oct. 4, 2012 — Pennsylvania Wildlife Conservation Officer David Grove died in a gunfight with a man he stopped on suspicion of poaching deer on Nov. 11, 2010.
On Oct. 2, a jury found Christopher Lynn Johnson, 29, of Fairfield, Pa., guilty of first-degree murder in Grove's death.
On Oct. 4, the jury that found him guilty issued its verdict in the penalty phase of Johnson's trial, choosing the death sentence over life in prison.
Grove, 31, was a resident of Fairfield, a small town in western Adams County. He had grown up in Waynesboro, Pa., in Franklin County, and was a graduate Grace Academy in Hagerstown.
The officer pulled over Johnson's pickup truck on a Freedom Township road, believing he was spotlighting and possibly poaching deer. Grove's radio communications with emergency services dispatchers were recorded prior to the shooting.
Johnson was prohibited from possessing a handgun due to a 2002 burglary conviction in Pennsylvania.
A man who was in the pickup with Johnson told police that Johnson pulled a .45-caliber handgun from his waistband as Grove was trying to take him into custody.
Johnson fired 15 shots — which meant he reloaded the semiautomatic handgun — and struck Grove four times, including a fatal wound to the neck. Grove got off 10 rounds and hit Johnson in the hip.
Police found Johnson at a hunting camp the morning after the shooting.
Grove was the first Pennsylvania Game Commission officer killed in the line of duty in 95 years.
— Don Aines
Sharpsburg-area raid
Nov. 29-Present — A Maryland State Police SWAT team raided a Sharpsburg-area man's property on Mills Road after receiving an anonymous tip that he had illegal firearms.
Two searches of 46-year-old Terry Porter's property at 4433 Mills Road produced four shotguns, a .30-30-caliber rifle and two .22-caliber rifles, according to court records.
One of the searches was conducted by warrant on Nov. 29. Porter consented to the second search a day later.
Police could not find Porter when they entered his property on Nov. 29. The next day, he surrendered to authorities.
Porter was charged Nov. 30 with seven counts each of being a convicted felon in possession of a rifle or shotgun and possession of firearms after being convicted of a disqualifying offense, court records show.
Porter's criminal record includes a 1992 conviction for aiding and abetting in the distribution of marijuana before a U.S. magistrate in West Virginia, according to U.S. District Court documents. He was sentenced to six months incarceration and three years probation in the case.
A person wishing to remain anonymous contacted state police in early November, telling troopers that Porter "has been getting crazier and crazier over the past several years," charging documents said. The person also told police that Porter had 10 to 15 "machine gun style firearms," six handguns, up to 10,000 rounds of ammunition and a bunker under his driveway.
State police called in an FBI SWAT team and the Washington County Special Response Team to assist at the scene.
The overwhelming police presence prompted some residents to accuse authorities of using excessive force. As a result, meetings were held Dec. 8 and Dec. 15 at Sharpsburg Town Hall to show support for Porter and to address the way police handled the situation.
On Dec. 19, a Washington County District Court judge granted Porter a continuance to give his attorney more time to prepare.
Online court records indicate Porter is to have a preliminary hearing on Jan. 30, 2013, at District Court.
— Dan Dearth


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TankBot: The iPhone-controlled tank robot
This is TankBot from DeskPets, a fairly inexpensive (sub-$20, they say), treaded, remote-controlled toy robot that you can control with an iPhone or an iPod Touch, or even an iPad.
While using iDevices as a remote is nothing new--indeed, Apple has an app simply called "Remote" for controlling the Apple TV--the TankBot is unique in that it doesn't use Bluetooth or Wi-Fi as an interface but rather a dongle that plugs into the headphone port of the iWhatever.
Once attached, an app is downloaded. The device then uses its built-in accelerometer as a steering mechanism, allowing … Read more


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Why Google's glad to dance to Vevo's tune
NEW YORK--Eric Schmidt's presence at a swanky music industry gathering was an illustration of how far digital technology has come and the power it has amassed.
A decade ago, the film studios and top record companies dismissed Northern Californians as a bunch of bearded dweebs who liked electronics. Five years ago, with illegal-file sharing spinning out of control, the entertainment industry looked on techies with fear and loathing, invaders to be repelled before they made off with the treasure. It wasn't that long ago that some in Hollywood considered Google a "rogue company."
Pfft. That's … Read more


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The Department of Family Medicine and Community Health provides primary health care services throughout the Central Massachusetts region. Family physicians provide a broad range of comprehensive primary health care services caring for the individual from birth to old age. The family physician specializes in taking care of you! Members of our clinical faculty provide obstetrical and newborn nursery care, basic childhood and adolescent care, and adult and geriatric care. I encourage you to meet our clinical faculty.Family Medicine Physicians
Family Medicine Physicians with Obstetrics
We are currently recruiting for faculty physicians at the following health centers in Central Massachusetts. For information regarding any of these open positions, please click here.


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Oil-rubbed bronze and a three-candle shape suggest colonial styling, but the contemporary lamp shades keep the Belmont outdoor chandelier casual for your outdoor setting. Oil rubbed bronze finish is weather-resistant. UL rated for wet locations. Includes 3 60-watt bulbs. 7" diameter lamp shades are designed for outdoor use. 6" on/off pull chain. 5" wire. 23"H (overall) x 21" diameter.


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Office of the Registrar
Commencement: 2013
:: Before You Graduate
Pay Your Balance
Graduating students with any balance due on their student account will be prevented from accessing grades or transcripts until the balance is paid in full. Students with a balance of $200.00 or more will be prevented from receiving their diplomas until their accounts have been paid in full.
To prevent any delays in receiving your diploma, please pay your student account in full. For assistance in settling your account, contact Student Financial Services at 656-5700.
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Once you've logged in navigate to the Registrar tab and select "Address" to see what we currently have on file.
If you need to make any changes simply select "Update" next to the address you'd like to alter.
:: Receiving Your Diploma
Graduates of the College of Arts & Sciences
Immediately following the Arts & Sciences ceremony graduates can pick up their diplomas at Royall Tyler Theatre. (In the event of rain diplomas will be distributed from the South University Heights complex.) Distribution of diplomas following the ceremony will be for a limited time only. Diplomas will be available for pick up at the Student Service Center (third floor Waterman) the week following commencement for graduates who are unable to collect their diplomas on the 19th.
All Other Graduates
If you are a graduate of a school or college other than the College of Arts & Sciences you should receive your diploma at your school or college's individual reception. For graduates who are unable to collect their diplomas on the 19th, diplomas will be available for pick up the week following commencement at the Student Service Center (third floor Waterman.)
:: Honors
The recipients of honors are determined when all grades for seniors have been submitted. We anticipate making available the names of those students who have earned honors the Thursday prior to commencement.For information regarding the ceremony visit the commencement website.
Last modified April 03 2013 09:45 AM


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LA Galaxy at Real Salt Lake - View from the Booth
Los Angeles Galaxy - 10 months ago
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Book Description:In this hilarious new book, Scott Adams introduces the Weasel Zone -- the giant gray area between good moral behavior and outright criminality. It's where your coworkers, bosses, salespeople, CEOs, human resource executives, hotel clerks, home repair people, and loved ones reside. In twenty-seven compelling chapters, Scott reveals the secrets of these slippery characters: how to recognize them, how they operate, how to stop them in their tracks -- and how you, too, can become a weasel. You'll learn the best practice weasel methods for avoiding work, besting coworkers, and hiding your incompetence. To enhance your personal life, you'll find precise instructions for training your spouse to become your remote-controlled robot, whining like a weasel no matter how good your life is (even if you're a bestselling author!) and using Weaseleze, the official tounge of weasels, to conceal your meaning and confuse your enemies.Read by Scott Adams
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I have written a number of times, from a range of perspectives, about the choices related to breast reconstruction. I strongly believe that every woman having a mastectomy (or bilateral mastectomies) should be given the necessary information to make the choice that is right for her. This covers a number of possibilities: no reconstruction, a delayed decision with possible reconstruction later, or immediate reconstruction either using expanders/implants or one of a number of flap surgeries. Unless a woman is completely sure that she does not want reconstruction, she should meet with a plastic surgeon to learn more about the options and make a better informed decision. Here is my current pet peeve: At some institutions, including sometimes our own, the mastectomy/reconstruction plan is presented as a single possibility -- e.g. "You will need a mastectomy, but you can have reconstruction at the same time." I think this is a mistake as no newly diagnosed woman is at her emotional or cognitive best, and this can start a chain of appointments and events that take on a life of their own. Although almost all women are eventually satisfied with the choice they have made, I surely have heard women lament the pressure of this decision period, and the retrospective sense that they were pushed in one or another direction at a time they could not advocate too well for themselves. In addition to meeting with a plastic surgeon, I think that all women considering reconstruction should also be given the chance to speak with other women who have made the same or a different decision. As we all know, you always hear something different from the patient than from the doctor. If you are in the midst of this turmoil, please contact me, and I can put you in touch with other thoughtful women who have made a range of choices. This is the best website with information about no reconstruction: www.breastfree. org
And this is an article, that stimulated today's entry, about reconstruction choices made by a cohort of women at Washington University in St Louis. Here is the abstract and then a link to read more:
Leisha Elmore, BS; Terence M. Myckatyn, MD; Feng Gao, PhD; Carla S. Fisher, MD; Jordan Atkins, BS; Tonya M. Martin-Dunlap, MD; and Julie A. Margenthaler, MD, FACS Objectives. The purpose of the current study was to conduct a patient-centered investigation of reconstruction practices following mastectomy at our institution.
Methods. A questionnaire was administered to patients who underwent unilateral or bilateral mastectomy for breast cancer from 2006 to 2010. The survey queried on demographics, surgical choices, and rationale for those choices. Data were summarized by contingency tables and compared by chi-square test or Fisher's exact test, as appropriate.
Results. Of 321 patients queried, 185 (58 %) underwent unilateral mastectomy and 136 (42 %) underwent bilateral mastectomy (mean age 56 ± 12 years). Overall, 189 (59 %) women underwent breast reconstruction, and 132 (41 %) did not. Immediate breast reconstruction was performed in 125 of 189 (69 %) women, whereas 67 of 189 (31 %) underwent delayed reconstruction. The method of definitive reconstruction included 143 of 189 (75 %) prostheses, 32 of 189 (17 %) abdominal tissue flap, 12 of 189 (6 %) latissimus flap (±implant), and 5 of 189 (2 %) with a combination of prostheses and tissue flaps. Of the 114 patients who did not undergo reconstruction, 68 (60 %) reported lack of desire for reconstruction as their motive, and the remaining 46 (40 %) reported medical contraindications for reconstruction or did not report a specific reason.
Conclusions. A significant percentage of women undergoing unilateral or bilateral mastectomy for breast cancer at our institution elect to undergo reconstruction. Prosthetic reconstruction was the most common method utilized. The impetus for referral to the reconstructive surgeon was nearly always initiated by the surgical oncologist. Read more »


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Posted: 7:00 a.m. Friday, Sept. 13, 2013
Is Jennifer Aniston threatening Justin Theroux's ex Heidi Bivens to stay out of Los Angeles? According to Star magazine, yes.
The tabloid says that information that Bivens was moving to LA to expand her stylist business did not sit well with Aniston. The gossip rag claims, "Everyone knows everyone in L.A., and Jen didn't want to cross paths with her. To make the move more challenging, Jen recruited Kate Young, one of Heidi's designer rivals from New York. Now that she's working with Jen, she's getting a lot of the West Coast jobs that could have gone to Heidi."
Star goes on to allege that Jen "felt threatened by the thought of having Heidi in the same city. She was convinced that Heidi and Justin would reconnect."
Anyways, this story is so not true. A source close to Aniston tells RumorFix the rumor is 100% not true.


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What So Sizzle Bout SizzlingSuzai?
she is Peter Gene Hernandez's true LOVE and she obsessed about Bruno from the Mars, men ("^^), FASHION, photography, K-pop, typo and lots of artistic reasons of her being a tumblr-ian!
XOXOBrunoMars is my own tumblr dedicated to my LOVE, mr. Bruno Mars. omg, he is damn GREAT! XD
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AH News Publication
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Dr Mark Hewitson awarded AHRC Fellowship
14 December 2012
Dr Mark Hewitson (Department of German) has been awarded one of only seven Arts and Humanities Research Council (AHRC) Fellowships for The Violence of War: Images and Experiences of Conflict, receiving £159,486.
The Fellowships have been established to increase research leadership capacity within the arts and humanities, through supportive individualised programmes of development, training and engagement.
The scheme provides time for research leaders, or potential future research leaders, to undertake focused individual research alongside collaborative activities which have the potential to generate a transformative impact on their subject area and beyond.
The awarded Fellows will work on their individual research projects alongside research leadership development, training and engagement activities which have the potential to generate impact within academia and beyond.
Through the life time of the award they will also act as advocates for the value and benefit of arts and humanities research to publics beyond academia.
The Arts and Humanities Research Council (AHRC) funds world-class, independent researchers in a wide range of subjects and will this financial year spend approximately £98m to fund research and postgraduate training in collaboration with a number of partners.


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Nokia Asha 306 review
The Nokia Asha 306 is a very basic smart phone but its biggest shortcoming is no 3G, which throttles web speeds away from Wi-Fi. Doh! Read more
10 September 2012 by Natasha Lomas
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LG Town C300 review
Its lush Qwerty keyboard is ideal for tapping out lengthy emails, but the LG Town C300's lack of 3G connectivity and the general shoddiness of its online experience make it hard to recommend wholeheartedly. Read more
5 November 2010 by Damien McFerran


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Location: Frankfurt Hahn, Germany
Ryanair is Europe's only ultra-low cost carrier (ULCC), operating more than 1,600 daily flights (over 500,000 per year) from 57 bases, across 1,600 low fare routes, connecting 180 destinations in 29 countries and operating a fleet of 303 new Boeing 737-800 aircraft. Ryanair has recently announced firm orders for a further 175 new Boeing aircraft, which will be delivered between 2014 and 2018. Ryanair currently has a team of more than 8,500 highly skilled professionals, will carry over 81.5 million passengers this year and has an outstanding 29-year safety record.
Bostonair are currently recruiting for a Trimmer, to be based in Frankfurt, Hahn, to work in cooperation with our client airline Ryanair, Europe's number one low fares airline.
Frankfurt Hahn boasts one of Ryanair's newest hangars. This is a two bay facility, with a dual flight simulator bay and training facilities attached. This person will be responsible for ensuring that the highest standard of cabin trim is applied to Ryanair's fleet of aircraft.
We are now increasing our manpower due to an expanding workload and internal promotions. This is an excellent chance to gain experience on the Boeing 737-800.
We offer a competitive salary with a night shift allowance (standard German night shift allowance tax incentives apply).
If you are an enthuastic, motivated person wanting to work in a fast paced, dynamic environment then this is the job for you!!
Closing Date: 25/06/2013
Please email full curriculum vitae with cover letter
(quoting reference number FRHHNT03) to
Training at
Please note only applications for the position of Trimmer - HHN will be accepted through the above email address,
applications for other positions, general enquiries or requests will not be processed.


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This item is eligible for leasing to those who have been in business for at least two years. Leasing terms range from 24 to 60 months, and can feature either $1 or 10% buyout options.
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This heavy duty three-way pan/tilt head is designed to handle up to 4 x 5 large format cameras. It features individual forward and side tilt locks and pan-locking knob for precise camera-placement control. It also offers the convenience of a quick-release camera plate with a 1/4-20 and 3/8 mounts, a safety lock and a built-in spirit level.


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tabstrip.css not loading in cms
27 July 2009 at 3:34am Last edited: 27 July 2009 3:34am
Has anyone ever experienced tabstrip.css not loading in the CMS? i am having this issue with one of my sites on my development server. On first login, the tabs and CMS panes do not display properly (see screenshot). However, if you click on the Site Content menu, it does reload everything and the layout is all the sudden fully loaded.
+ I have tried creating 2 separate environments of my site with versions 2.3.1 and 2.3.2 -> same thing happens everytime in both environments
+ I have tried deleting dataobject_manager and swfupload, the 2 modules loaded - also commented out all code referencing these modules in mysite/code objects -> same result in both environments
+ I have cleared the cache in silverstripe-cache folder and cleared the browser cache after making each change -> same result
+ Each iteration I have tested in IE as well as Firefox, so does not seem to be browser-specificI have not noticed this on any of the other sites i have ever built, so i am completely baffled. Does anyone know where else i can look to see where this is being caused?
Re: tabstrip.css not loading in cms
31 July 2009 at 3:48pm
if anyone ever comes across this issue, i was able to find the culprit. after process of elimination, it was actually caused by one of my .php class files in my code folder. I evidently had 2 return lines below the closing php tag in one of my class files. when i deleted them on this one class, everything began appearing correctly in the CMS page edit window.
Re: tabstrip.css not loading in cms
1 October 2009 at 9:02pm
Solved mine too! Thanks for following that up it was driving me up the wall...
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will make you the envy of your neighborhood! Each custom mailbox is a hand painted by Artist Sandra Davis. We have dozens upon dozens of patterns that will spark your creative side to decorate your home. Flipping through our site, you will find lots of patterns with birds, like bluebirds, hummingbirds, cardinals and more! We have lots of flowers to fill the blank void of a plain mailbox. Iris, hydrangeas, daisy, magnolias, and geranium mailboxes are a few of the lovely locking flower mailboxes Sandra's Decor has on display. For those nautical minded home decor we have wonderful scenes of dolphin mailboxes, lighthouse mailbox and mailboxes, beach mailboxes and palm trees mailboxes and many different types of fish mailboxes.
Having trouble choosing a postal mailbox? Where you need a rural or residential mailbox, here are some tips to consider that will help you decide on a decorative mailbox.
Customer Feedback
Hi Sandra, I got my mailbox & it is sooooo beautiful!My son will put it up on his day off, I already waxed it super good.I will take a pic & send it to you. Aloha Gerry, HI
Thank you very much. You do beautiful work. Susan, FL
It was so nice to speak with you again this afternoon. As mentioned, my Pink Geranium Mailbox was received last week. It is absolutely beautiful. I have a large window in my living room and everytime I go past I can see the mailbox and it makes me smile. I'm extremely impressed with your art work and will highly recommend you to my friends and neighbors. Thanks again. Dee from NJ
We received the mailbox today! Thank you so much for getting it here on time! It is soooo pretty! Looks a million times better in person! Could not be happier w it! Will probably be getting another order from me for a beach themed one in the near future. Thanks, Katie
I just thought that I would let you know that despite my son telling grandpa that he had a fish mailbox as a present, he loved it!! When I need another mailbox done, I will definitely be getting it from you!! ....... Tina Wisconsin
...just wanted to tell you the mailbox is absolutely precious!.... Catherine Virginia
Wow, Sandra, It is Beautiful, My Grandmother already opened here gift and loves it..... Cindy Florida
It Arrived today and we love it... Can't wait for our son to get home and see the Flag... Richard Texas
Thank you Sandra, The Dogs look great, just as we remember Ralph & Wendy California
Arrived today, can't wait till Mom & dad open it on Christmas Becky G Oldsmar, Fl
I put it up today, my neighbors want one too... " Janice Vermont
...arrived today and its beautiful - my daughter loves it... " Darien Canada
"...arrived today and is gorgeous, she will absolutely love it... " Kathleen Maryland


text: Sounds like a stupid Question... but we're still right in the middle of a rebuild, winning 20/25 games this season could set us back a few years? What We've needed for years is a legitimate big and in this draft With Noels and Zeller there's an opportunity to draft a potential future all star... If and only if we get a high draft pick. Thoughts?


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Jewish foundation creates 'Jewish Nobel Prize'
By GIL SHEFLER
06/26/2012 21:52
Group founded by Russian-Jewish oligarchs to bestow annual $1m prize for achievements in arts, sciences or activism.
Albert Einstein
Photo: Courtesy
A Jewish foundation on Tuesday announced the creation of an annual award with a one million dollar cash prize that will be bestowed upon a personality with strong ties to the Jewish people for his or her achievements in the fields of art, science or diplomacy
The Genesis Philanthropy Group headed by Russian-Jewish businessmen including billionaires Mikhail Fridman, Pyotr Aven and German Khan, among others, said the Genesis Prize, which has been likened to a "Jewish Noble Prize," would help strengthen ties between Israel and the Diaspora.
"The Genesis Prize emphasizes the contribution of the Jews to world history," Fridman was quoted as saying in a press release. "Far-reaching achievements in science, the arts, business, medicine, diplomacy and other fields of human endeavor have been realized thanks to the Jewish people's natural aspiration to improve the world and to its desire to pass its moral values on to coming generations. This tradition of the Jewish people must continue."
The announcement was made during a meeting in Jerusalem between Fridman, Prime Minister Binyamin Netanyahu and Jewish Agency for Israel Chairman Nathan Sharansky.
The one million dollar award would put the new accolade on a par with the famous Noble Prize, which comes with a $1.1 million gift. So far about 20 percent of Noble Prize laureates have been Jewish, a staggering number considering Jews make up about 0.2 percent of the world's population. Jewish recipients of the Noble include the likes of physicist Albert Einstein, author Shai Agnon; and slain prime minister Yitzhak Rabin and current President Shimon Peres, who received the award together.
Honorees for the Genesis Prize will be chosen by two committees composed of retired judges, Diaspora Jewish community leaders, government officials, Genesis Philanthropy Group representatives and Sharansky in his capacity as JAFI head.
"There are two important things here beside the considerable cash sum," Sharansky told
The Jerusalem Post
over the phone. "The recipient will be someone who has done something important for humanity in the fields of science, arts, diplomacy and so on. At the same time the person will be a proud Jew with strong ties to the community and Judaism. Why is this important? We need role models, we need people that contribute to society."
Sharansky avowed for the transparency of the selection process, saying the most likely candidate would be one who is Jewish and is involved in Jewish activity. At the same time, the former Soviet Refusenik added non-Jews who have contributed in a significant way to to Jewish civilization might also be considered.
The sizable endowment made by Fridman, Aven and Khan --who are also partners in the Alfa Group, a corporate giant with holdings in many different interests-- as well as others, ensures it will be given in perpetuity, the Genesis Philanthropy Group told
The Jerusalem Post
. Fridman, whose net worth was estimated at 13.4 billion in 2012, making him the seventh richest man in Russia, was part of a group of Russian Jewish businessmen who came to Israel earlier this week to accompany Russian President Vladimir Putin on his visit to Israel.
Stan Polovets, CEO of Genesis Philanthropy Group, said he hoped the first winner of the prize was expected to be announced before Passover next year but that it "will depend on how quickly the project will get staffed, nomination and selection committees start functioning, etc."
Netanyahu congratulated the charity's decision, calling the prize a symbol of the "Jews' great contribution in human development."
"The Jewish people has developed excellence over the years due thanks to its values and heritage," Netanyahu said. "This is an important step for the cohesion of our people and symbolizes its unity around Jewish values."
In the meantime Sharansky said he could think of many potential nominees for the award, but saying who he had in mind would be premature.
"There are some Jews i would like to win, but how can we start playing with the names now --it's too early," he said.
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Penetrance and Expressivity of MSH6 Germline Mutations in Seven Kindreds Not Ascertained by Family History The American Journal of Human Genetics, Volume 74, Issue 6, 1 June 2004, Pages 1262-1269 Barbara M. Buttin, Matthew A. Powell, David G. Mutch, Sheri A. Babb, Phyllis C. Huettner, Tina Bocker Edmonston, Thomas J. Herzog, Janet S. Rader, Randall K. Gibb, Alison J. Whelan and Paul J. Goodfellow Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by inherited mutations in DNA mismatch-repair genes, most commonly MLH1 or MSH2. The role MSH6 plays in inherited cancer susceptibility is less well defined. The aim of this study was to investigate the penetrance and expressivity of MSH6 mutations in kindreds ascertained through endometrial cancer probands unselected for family history. Detailed pedigrees were constructed for six MSH6 mutation carriers. All reported cancers and precancers were confirmed, and tissues were obtained when available. Tumors were analyzed for microsatellite instability (MSI) and for expression of MSH2, MLH1, and MSH6. MSH6 mutation status was determined for 59 family members. Of these 59 individuals, 19 (32%) had confirmed cancers and precancers. There was an excess of mutation carriers among the 19 affected family members (11 [58%] of 19) compared with those among the 40 unaffecteds (8 [20%] of 40, P=.0065, odds ratio = 5.5, 95% CI = 1.66–18.19). In four of the seven tumors analyzed from mutation carriers other than the probands, MSI and/or MMR protein expression was consistent with the involvement of MSH6. Overall estimated penetrance of the MHS6 mutations was 57.7%. Of the tumors in mutation carriers, 78% were part of the extended HNPCC spectrum. This study demonstrates that MSH6 germline mutations are, indeed, associated with increased cancer risk and that the penetrance of mutations may be higher than appreciated elsewhere. A combination of MSI and immunohistochemistry analyses may be helpful in screening for MSH6 mutation carriers. Abstract | Full Text | PDF (475 kb) |
Association of Hereditary Nonpolyposis Colorectal Cancer–Related Tumors Displaying Low Microsatellite Instability with MSH6 Germline Mutations The American Journal of Human Genetics, Volume 65, Issue 5, 1 November 1999, Pages 1291-1298 Ying Wu, Maran J.W. Berends, Rob G.J. Mensink, Claudia Kempinga, Rolf H. Sijmons, Ate G.J. van der Zee, Harry Hollema, Jan H. Kleibeuker, Charles H.C.M. Buys and Robert M.W. Hofstra Abstract Summary Hereditary nonpolyposis colorectal cancer (HNPCC) (Amsterdam criteria) is often caused by mutations in mismatch repair (MMR) genes, and tumors of patients with HNPCC show microsatellite instability (MSI-high phenotype). Germline mutations of MMR genes have rarely been found in families that have HNPCC or suspected HNPCC and that do not show microsatellite instability (MSI-low phenotype). Therefore, an MSI-high phenotype is often used as an inclusion criterion for mutation testing of MMR genes. Correction of base-base mismatches is the major function of MSH6. Since mismatches present with an MSI-low phenotype, we assumed that the phenotype in patients with HNPCC-related tumors might be associated with MSH6 germline mutations. We divided 36 patients with suspected HNPCC into an MSI-low group (n=18) and an MSI-high group (n=18), on the basis of the results of MSI testing. Additionally, three unrelated patients from Amsterdam families with MSI-low tumors were investigated. All patients were screened for MSH2, MLH1, and MSH6 mutations. Four presumably causative MSH6 mutations were detected in the patients (22%) who had suspected HNPCC and MSI-low tumors. Furthermore, we detected one frameshift mutation in one of the three patients with HNPCC and MSI-low tumors. In the MSI-high group, one MSH6 missense mutation was found, but the same patient also had an MLH1 mutation, which may explain the MSI-high phenotype. These results suggest that MSH6 may be involved in a substantial proportion of patients with HNPCC or suspected HNPCC and MSI-low tumors. Our data emphasize that an MSI-low phenotype cannot be considered an exclusion criterion for mutation testing of MMR genes in general. Abstract | Full Text | PDF (131 kb) |
Molecular Analysis of Hereditary Nonpolyposis Colorectal Cancer in the United States: High Mutation Detection Rate among Clinically Selected Families and Characterization of an American Founder Genomic Deletion of the MSH2 Gene The American Journal of Human Genetics, Volume 72, Issue 5, 1 May 2003, Pages 1088-1100 Anja Wagner, Alicia Barrows, Juul Th. Wijnen, Heleen van der Klift, Patrick F. Franken, Paul Verkuijlen, Hidewaki Nakagawa, Marjan Geugien, Shantie Jaghmohan-Changur, Cor Breukel, Hanne Meijers-Heijboer, Hans Morreau, Marjo van Puijenbroek, John Burn, Stephany Coronel, Yulia Kinarski, Ross Okimoto, Patrice Watson, Jane F. Lynch, Albert de la Chapelle, Henry T. Lynch and Riccardo Fodde Abstract The identification of germline mutations in families with HNPCC is hampered by genetic heterogeneity and clinical variability. In previous studies, MSH2 and MLH1 mutations were found in approximately two-thirds of the Amsterdam-criteria–positive families and in much lower percentages of the Amsterdam-criteria–negative families. Therefore, a considerable proportion of HNPCC seems not to be accounted for by the major mismatch repair (MMR) genes. Does the latter result from a lack of sensitivity of mutation detection techniques, or do additional genes underlie the remaining cases? In this study we address these questions by thoroughly investigating a cohort of clinically selected North American families with HNPCC. We analyzed 59 clinically well-defined U.S. families with HNPCC for MSH2, MLH1, and MSH6 mutations. To maximize mutation detection, different techniques were employed, including denaturing gradient gel electrophoresis, Southern analysis, microsatellite instability, immunohistochemistry, and monoallelic expression analysis. In 45 (92%) of the 49 Amsterdam-criteria–positive families and in 7 (70%) of the 10 Amsterdam-criteria–negative families, a mutation was detected in one of the three analyzed MMR genes. Forty-nine mutations were in MSH2 or MLH1, and only three were in MSH6. A considerable proportion (27%) of the mutations were genomic rearrangements (12 in MSH2 and 2 in MLH1). Notably, a deletion encompassing exons 1–6 of MSH2 was detected in seven apparently unrelated families (12% of the total cohort) and was subsequently proven to be a founder. Screening of a second U.S. cohort with HNPCC from Ohio allowed the identification of two additional kindreds with the identical founder deletion. In the present study, we show that optimal mutation detection in HNPCC is achieved by combining accurate and expert clinical selection with an extensive mutation detection strategy. Notably, we identified a common North American deletion in MSH2, accounting for ∼10% of our cohort. Genealogical, molecular, and haplotype studies showed that this deletion represents a North American founder mutation that could be traced back to the 19th century. Abstract | Full Text | PDF (310 kb) |
Copyright © 2002 The American Society of Human Genetics All rights reserved.
The American Journal of Human Genetics, Volume 70, Issue 1, 26-37, 1 January 2002
Maran J.W. Berends1, Ying Wu2, Rolf H. Sijmons2, Rob G.J. Mensink2, Tineke van der Sluis3, Jannet M. Hordijk-Hos2, Elisabeth G.E. de Vries4, Harry Hollema3, Arend Karrenbeld3, Charles H. C.M. Buys2, Ate G.J. van der Zee5, Robert M.W. Hofstra2 and Jan H. Kleibeuker1, ,
1 Department of Gastroenterology, The Netherlands
2 Department of Medical Genetics, The Netherlands
3 Department of Pathology, The Netherlands
4 Department of Medical Oncology, The Netherlands
5 Department of Gynaecology, University Hospital Groningen, Groningen, The Netherlands
The MSH6 gene is one of the mismatch-repair genes involved in hereditary nonpolyposis colorectal cancer (HNPCC). Three hundred sixteen individuals who were known or suspected to have HNPCC were analyzed for MSH6 germline mutations. For 25 index patients and 8 relatives with MSH6 variants, molecular and clinical features are described. For analysis of microsatellite instability (MSI), the five consensus markers were used. Immunohistochemical analysis of the MLH1, MSH2, and MSH6 proteins was performed. Five truncating MSH6 mutations, of which one was detected seven times, were found in 12 index patients, and 10 MSH6 variants with unknown pathogenicity were found in 13 index patients. Fourteen (54%) of 26 colorectal cancers (CRCs) and endometrial cancers showed no, or only weak, MSI. Twelve of 18 tumors of truncating-mutation carriers and 3 of 17 tumors of missense-mutation carriers showed loss of MSH6 staining. Six of the families that we studied fulfilled the original Amsterdam criteria; most families with MSH6, however, were only suspected to have HNPCC. In families that did not fulfill the revised Amsterdam criteria, the prevalence of MSH6 variants is about the same as the prevalence of those in MLH1/MSH2. Endometrial cancer and/or atypical hyperplasia were diagnosed in 8 of 12 female carriers of MSH6 truncating mutations. Most CRCs were localized distally in the colon. Although, molecularly, missense variants are labeled as doubtfully pathogenic, clinical data disclose a great resemblance between missense-variant carriers and truncating-mutation carriers. We conclude that, in all patients suspected to have HNPCC, MSH6-mutation analysis should be considered. Neither MSI nor immunohistochemistry should be a definitive selection criterion for MSH6-mutation analysis.


text:
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smells nice it also feels really great on my skin it makes it really soft, great product I recommend to everyone and keep it in my purse.
This lotion feels great on my hands and my boyfriend absolutely loves the scent. "Very appealing" I will definitely be buying more!
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Not a fan. Smells like pencils and the moisture doesn't stay long. I gave it to a friend who enjoys it but it's not for me.
I also liked the scent of this lotion, and agree with the woodsy/pencil shaving smells noted in previous reviews. It's moisturizing and lasts even after you wash you hands.
exactly, the lotion is luxurious, but it smells like a sharpened number two pencil....not something i want to smell like
I ordered this cream after getting the sample in my last BB box and fell deeply in love with both the scent and the wonderful healing powers of the product. I'm not sure what scent I have right now but my nose knows what scent is going on my body and if my cat could talk he for sure would tell me. Since sniffing all my BB products is his favorite pastime along with eating. This is truly the most healing product for my knees and heels, which for some reason seem to be the most dry on my body.
I liked the scent of this lotion, and would echo a previous review that it smells somewhat of pencil shavings. But in a good way - really. It's light and woodsy without being too floral or overpowering. And it's smooth without being greasy.
Best body cream to use on the daily. Nt greasy and stays moisturizing even in the harshest weather. Favorite hand cream to date.
This is the first sample that I have been disappointed with. I received the Femme smell and it reminded me of a vase of flowers that had wilted and died... a very mossy, earthy smell. wouldn't recommend this one to anyone!


text:
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Our 48 m2 Deluxe Suites comprising of two rooms are designed for unrivalled relaxation and provide that extra bit of space and luxury that can turn a great holiday into a perfect one. Each room comes complete with a private balcony, beautiful views over the shimmering Mediterranean Sea and all the luxuries you'd expect from a fine, five-star hotel. These include a TV with cable and satellite, complimentary Wi-Fi and tea and coffee making facilities.
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- 75 TV channels
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- 43m2
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text:
TOC's sexpert shows you a whole new way to appreciate fruits and veggies (and chocolate)-without ending up in the ER.
Mon Oct 20 2008
Given the current economic climate, people are looking to cut costs wherever they can—including in the bedroom. Before you spend big bucks on a double-action, multispeed vibrator with ball bearings and Paris Hilton–worthy rhinestones, why not check out what's available at the grocery store? With a little forethought and imagination, you might be surprised at the myriad ways foods can satisfy a different kind of craving.
Cucumbers When it comes to poor-man's (or woman's) dildos, nothing does a better stand-in job than a cucumber. But size does matter: Some cucumbers can be painfully porn-star–sized. Look for one that's no larger than what could comfortably fit inside you for vaginal or anal play and never, ever, ever insert produce into the vagina or anus without slipping a lubricated condom over it to reduce potential irritation from chemicals, pesticides or bacteria not meant for one's genitals. If using cucumbers for anal play, hold onto the end of the condom for dear life, lest the condom-clad cucumber get sucked up inside your body and make you the laughingstock of the ER. Zucchini and yellow squash also make good dildo understudies.


text: Abedini is only the most recent human rights advocate to be imprisoned by Iran for threatening national security. Earlier this month Iranian lawyer and prominent human rights activist Nasrin Sotoudeh [JURIST news archive] was temporarily released after spending over two years in prison [JURIST report] in Tehran for her September 2010 conviction for propaganda and harming national security. Iranian authorities pursued Sotoudeh because she represented political activists and sought to highlight the execution of juveniles in the country. In December Sotoudeh ended a 49-day hunger strike [JURIST report] in protest of her prison conditions and a travel ban imposed on her family. UN High Commissioner for Human Rights Navi Pillay had expressed concern for Sotoudeh's deteriorating health and urged the Iranian government to lift the travel ban, saying the ban was not justified by international law. After judicial authorities agreed to lift the travel ban on Sotoudeh's daughter, Sotoudeh ended her strike. Sotoudeh was sentenced in January 2011 to 11 years in prison after being found guilty of "acting against national security" and "making propaganda against the system" for which she will serve five and one years, respectively.


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Pierre Corneille
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Le Cid
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text:
Error : Several Java virtual machines running in the same process; Java Runtime Environment cannot be loadedThis article applies to:
SYMPTOMS While running some Java applets user gets error saying Several Java Virtual Machines running in the same process or Java Runtime Environment cannot be loaded CAUSE We are still investigating root cause of this issue. WORKAROUND Below are some of the workarounds that have worked for different users. Try Setting Virtual Memory
Set JRE parameter to Less than 3/4th of Actual Physical Memory in Your System
Uninstall All Versions of Java through the Control Panel
Disable Add-ons in Internet Explorer


text:
Mavs beat Blazers in craziest game of the season
How crazy was the Mavs' win over the Trail Blazers? Let us count the runs...
How crazy was the Mavs' win over the Trail Blazers? Let us count the runs...
Kliff Kingsbury just landed himself a major recruit for the 2015 season.
VIEW MORE »Ian Kinsler isn't too fond of his time with his former team. But what about Jarrod Saltalamacchia?
VIEW MORE »Texas centerfielder Leonys Martin talks a lot about how he's more comfortable this spring as he prepares for his second full season in the majors.
VIEW MORE »Here are 10 free agents that could be productive for the Cowboys if they can be obtained at a low price.
VIEW MORE »Sick of hearing how the Dallas Cowboys won't be major players when free agency begins on March 11? Well, this isn't going to make you feel any better, but hopefully more informed.
VIEW MORE »The Spurs had some extra support on the bench against the Heat on Thursday, but they didn't need any extra help on the court.
VIEW MORE »According to one NFL Draft expert, rumor has it the Texans don't think Johnny Manziel is a fit for the team.
According to a report, Johnny Manziel agrees to partner up with Nike for his marketing rights.
Oklahoma looking to follow up on successful 2013 season that ended with a Suger Bowl victory over Alabama.
VIEW MORE »While not every Baylor fan is enthused about the basketball team's new 'Sic 'em' postseason jerseys, RGIII couldn't wait to put one on himself and show it to the world.
Saints TE Jimmy Graham travels to the Middle East to visit U.S. troops at military bases while on deployment.
VIEW MORE »Former Cowboys coach Wade Phillips still without a job, and he's let everyone know on Twitter while he continues to wait for a phone call.
VIEW MORE »Former TCU quarterback Casey Pachall has helped contribute to what could be a bumpy road to the NFL for the ex Horned Frog signal caller.
VIEW MORE »New Dallas Stars goaltender Tim Thomas definitely realizes just how great it is to go from a team in the Florida Panthers that was treading water in the Eastern Conference to one like the Stars, who have a legitimate shot at making the 2014 NHL Stanley Cup Playoffs.