text:
1200 sq. ft. | 2 Bedroom | 2 Bath | Occupancy 4
Great 2BR, 2BA fairway view condo! Our unit is located on the second floor. Building #6
The Masterbedroom has a golf course view and a King size bed
The Second bedroom has two twin beds.
There is a full kitchen, and a living room with a flat screen TV
You can relax on the lanai overlooking the Kona Country Club golf course near the famous "big splash" blow hole (a must see in larger surf!)
- Ocean View — Peek-a boo view
- Mountain View
- Golf Course Front
- Kitchen - Full
- Laundry - In Unit
- Pool - Shared
- Parking - Free
- Golfing Nearby
- Tennis Courts (3)
- Surfing - Nearby
- Internet - Wireless [Free]
- Free Local Calls
- Telephone
- King Bed
- Twin/Single Bed (2)
- The lanai provides a startling view of the Kona Country Club Golf Course, near the famous "grand splash" blow hole (a must-see in larger surf!). The wrap-around lanai also has views of the mountainside above Keauhou Bay and peek-a-boo views of the ocean.
- Wrap-around lanai
Entry Area
- Tile entry with local artist originals
Pleasant stay at 6-204
Reviewed by Martha
Date 07/28/2013
We had a pleasant and nice stay at unit 6-204. The place was clean and it had almost everything we needed for our stay. The location was good and close to many points of interest. The unit was a good size and it felt like home. The local area contact, Allen Wong, gave us a warm welcome and was very helpful in giving us suggestion on things to do and places to see.
Perfect Location / Excellent Value
Reviewed by Sherrie
Date 12/20/2012
We enjoyed our stay in condo 6-204! The condo was clean, comfortable, and in an extremelly safe location. The kitchen was well stocked with needed items, and we were able to cook at least 2 meals everyday which saved us a lot of money. Stores are close by and have everything you need. White sandy beaches and great snorkeling are a short 5 minute walk away. Sipping Kona coffee on the lani in the morning was the perfect start to every day. I would highly recommend this unit.
Lovely stay
Reviewed by Rene
Date 08/10/2012
We stayed for only 5 nights at the Keauhou Kona Sulf club and we wishes it would be much longer. The condo has everything, nice beds, full kichen great livingroom and an ever greather lanai. The stay there was a feast.
Have Questions? See the FAQs
Owner/Manager: Margie Parker
Phone: 847-922-7746
Email: email@example.com
Tax ID: W30392064-01


text:
Type 1 Diabetes Unit
Type 2 Diabetes Unit
Obesity Unit
Cardiovascular Metabolism Unit
Translational Research
Division of Endocrinology, Diabetes and Metabolism
Diabetes Research Center
Anne Rentoumis Cappola
Associate Professor of Medicine
Contact information
Division of Endocrinology, Diabetes, and Metabolism
Room 12-136
Smilow Center for Translational Research, 12th floor
3400 Civic Center Blvd., Building 421
Philadelphia, PA 19104-5160
Office: (215) 573-5359
Fax: (215) 898-5408
Graduate Group Affiliations
Epidemiology and Biostatistics
Search PubMed for articles
Search PubMed for articles
School of Medicine Faculty
Division of Endocrinology, Diabetes, and Metabolism Faculty
B.A. (Biochemistry )
Harvard College (Advanced Standing), Cambridge, MA, 1990.
University of Pennsylvania School of Medicine, 1994.
Sc.M. (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2001.
Permanent link
IDOM Home
DRC Home
Description of Research Expertise
Anne Rentoumis Cappola, M.D., Sc.M. is an Associate Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism, Associate Scholar in the Center for Clinical Epidemiology (CCEB), Core Faculty Member of the Master's in Translational Research program, and a Fellow in the Institute on Aging. She is an Associate Editor for the Journal of the American Medical Association (JAMA).
Dr. Cappola's research focuses on the hormonal alterations that occur with aging and the clinical impact of these changes. She is funded by the National Institute on Aging. Current projects include studies of the indications for treatment of subclinical thyroid dysfunction in older men and women; the role of androgens in the health of older women; hormonal treatments for the frailty syndrome; and metabolic changes in men and women who sustain a hip fracture.
Selected Publications
Sanders JL, Ding V, Arnold AM, Kaplan RC, Cappola AR, Kizer JR, Boudreau RM, Cushman M, Newman AB
Do changes in circulating biomarkers track with each other and with functional changes in older adults?
J Gerontology Med Sci 69(2): 174-81, Feb 2014.
Medici M, Porcu E, Pistis G, Teumer A, Brown SJ, Jensen RA... Cappola A, Toniolo D, Sanna S, Naitza S, Peeters RP
Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease
PLOS Genetics 10(2): e1004123, Feb 2014.
Maggio M, Snyder PJ, De Vita F, Ceda GP, Milaneschi Y, Lauretani F, Luci M, Cattabiani C, Peachey H, Valenti G, Cappola AR, Longo DL, Ferruicci L
Effects of transdermal testosterone treatment on inflammatory markers in elderly men
. Endo Pract In press 2014.
Liu Z, Cappola AR, Crofford LJ, Guo W
Modeling bivariate longitudinal hormone profiles by hierarchical state space models
. JASA In press 2014.
Shores MM, Biggs ML, Arnold AM, Smith NL, Longstreth WT, Kizer JR, Hirsch CH, Cappola AR, Matsumoto AM
Testosterone, dihydrotestosterone and incident cardiovascular disease and mortality in the Cardiovascular Health Study
. J Clin Endocrinol Metab In press 2014.
Garin MC, Arnold AM, Lee JS, Tracy RP, Cappola AR
Subclinical hypothyroidism, weight change, and body composition in the elderly: the Cardiovascular Health Study
J Clin Endocrinol Metab In press 2014.
Mariani LH, White MT, Shults J, Anderson CA, Feldman HI, Wolf M, Reese PP, Denburg MR, Townsend RR, Lo JC, Cappola AR, Carlow D, Gadegbeku CA, Steigerwalt S, Leonard MB,
Increasing use of vitamin D supplementation in the Chronic Renal Insufficiency Cohort Study
. J Ren Nutr In press 2014.
González-Fernández M, Humbert I, Winegrad H, Cappola AR, Fried LP
Dysphagia in old-old women: Prevalence as determined by self-report and the 3 oz. water swallowing test
. J Amer Geriatr Soc In press 2014.
Chen CT, Liu CT, Chen GK, Andrews JS, Arnold AM, Dreyfus J, Franceschini N, Garcia ME, Kerr KF, Li G, Lohman KK, Musani SK, Nalls MA, Raffel LJ, Smith J, Ambrosone CB, Bandera EV, Bernstein L, Britton A, Brzyski RG, Cappola A, Carlson CS, Couper D, Deming SL, Goodarzi MO, Heiss G, John EM, Lu X, Le Marchand L, Marciante K, McKnight B, Millikan R, Nock NL, Olshan AF, Press MF, Vaiyda D, Woods NF, Taylor HA, Zhao W, Zheng W, Evans MK, Harris TB, Henderson BE, Kardia SL, Kooperberg C, Liu Y, Mosley TH, Psaty B, Wellons M, Windham BG, Zonderman AB, Cupples LA, Demerath EW, Haiman C, Murabito JM, Rajkovic A
Meta-analysis of loci associated with age at natural menopause in African-American women
. Hum Mol Genet In press 2014.
Demerath EW, Liu CT, Franceschini N, Chen G, Palmer JR, Smith EN, Chen CT, Ambrosone CB, Arnold AM, Bandera EV, Berenson GS, Bernstein L, Britton A, Cappola AR, Carlson CS, Chanock SJ, Chen W, Chen Z, Deming SL, Elks CE, Evans MK, Gajdos Z, Henderson BE, Hu JJ, Ingles S, John EM, Kerr KF, Kolonel LN, Le Marchand L, Lu X, Millikan RC, Musani SK, Nock NL, North K, Nyante S, Press MF, Rodriquez-Gil JL, Ruiz-Narvaez EA, Schork NJ, Srinivasan SR, Woods NF, Zheng W, Ziegler RG, Zonderman A, Heiss G, Gwen Windham B, Wellons M, Murray SS, Nalls M, Pastinen T, Rajkovic A, Hirschhorn J, Adrienne Cupples L, Kooperberg C, Murabito JM, Haiman CA
Genome-wide association study of age at menarche in African-American women
. Hum Mol Genet 22(16): 3329-46, Aug 2013.
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Last updated: 03/07/2014
The Trustees of the University of Pennsylvania

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Tuesday's Analyst Moves: Apple Inc., Macy's, Inc, The Kroger Co., More (AAPL, M, KR, More)
March 11, 2014
Before Tuesday's opening bell, a number of big name dividend stocks were the subject of analyst moves. Below, we highlight the important analyst commentary for investors. Pacific Crest Upgrades Apple... Read More
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Welcome to the Old Carolians website which is run for and by former pupils of King Charles I School, Kidderminster and present and former members of staff of the School.
The Old Carolians Association was formed in 1912 by former pupils of King Charles 1 Grammar School for Boys, Kidderminster. Further details are given in the "About Us" section of this website.
Our Website:
- is intended to keep members, prospective members and non-members alike aware of past and future activities of the Association and news of the School and of our members.
- is complimentary to the "The Old Carolian" Magazine, published annually in October, and which is the official and permanent record of the Association's business.
Present School | Old Grammar School |
Click here to access the list of current members and their date of leaving school. If you would like to become a member and are eligible to join, please click to download a membership application form in .pdf format. Print it off, fill it in and send it with your remittance to the Membership Secretary at the address shown on the form.
We extend a very warm welcome to the following new members who have recently joined us:
Name | Left | Name | Left | Name | Left |
Graham Stradling | 1950 | Jackie Harvey | 1982 | Vicky Craghill | 1982 |


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Chimchar Forums is a peaceful pokemon community.
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Double-walled vacuum-sealed construction keeps your water cool for hours and prevents condensation from forming on the outside of the bottle. Naturally 100% BPA-Free, taste-free stainless steel doesn't require inner liners or plastic coatings like those used in aluminum bottles. Redesigned cap for greater durability and faster flow from our patented flip-top bite valve that lets you sip without tipping or spilling. Integrated loop handle for carrying convenience. Dishwasher safe.
Double-Wall vacuum insulation keeps water cool for hours
Flip, Bite and Sip. No tipping required (though possible: just remove the straw)
Durable and spill-proof
Easy to carry: Integrated loop handle makes it easy to clip a carabiner or carry with the crook of a finger
Naturally 100% BPA-Free, taste-free stainless steel. No inner liners or plastic coatings that aluminum bottles require.
Wide-mouth opening is easy to fill with ice and water and a breeze to clean
CamelBak® Big Bite™ Valve is compatible with CamelBak® eddy™ and CamelBak® Groove® bottles
CamelBak® Got Your Bak™ Guarantee: If we built it, we'll Bak it™ with our lifetime guarantee.
CLEANING THE EDDY STAINLESS The eddy Stainless bottle can be easily cleaned with a bottle brush using warm water and mild soap.
Cleaning the lid: The bite valve, straw and lid can be cleaned in the top rack of the dishwasher or by hand with warm, soapy water. Pull off the bite valve and straw from the cap. If you like to use a bottle brush, we don't recommend forcing a brush through the Bite Valve slit. If you have the brush kit, run the small brush through the straw.
For a deeper cleaning, add a drop of mild soap or tablespoon of bleach to a clean glass jar filled with water. Drop the bite valve, straw and cap into the solution, and tightly close the jar's lid. Shake the mixture around for 30 seconds, and then let the parts soak for about 15 minutes. Rinse and shake dry.
To re-assemble the lid: Flip the stem collar (the component the bite valve attached to originally) to the open position. Orient the bite valve so the finger tab points towards the front of the cap. Push the bite valve firmly onto the stem collar. Press the straw back into place on the bottom of the lid. Ensure the straw covers the notches completely.
The bite valve on my new bottle doesn't have a slit (opening) and I can't drink from it The self-sealing silicone can sometimes seal tightly before first use. To open, squeeze the bite valve and twist & roll between your fingertips. This should loosen the seal and open it up for drinking. If you're still experiencing problems, please request a new bite valve using our Warranty Parts Form. What are CamelBak® Stainless Bottles made of? All materials in CamelBak® bottles are selected for their safety, durability, and cleanability. All materials are BPA-free and safe for use in a hydration bottle. CamelBak® does not use materials that contain harmful phthalates.
The new CamelBak® eddy™ Stainless Insulated .5L and eddy™ Stainless .7L are made with medical-grade stainless steel. Stainless steel is a special type of steel that is naturally stain-resistant, corrosion-resistant and taste free. Because of these unique benefits, stainless steel is used in a variety of products from cookware and mugs to medical and surgical devices and food processing equipment. Stainless steel is strong, scratch-resistant and provides a naturally bright, clean finish without coatings or paints.
The CamelBak® eddy™ caps used on our stainless steel bottles are made primarily from polypropylene, with other plastics that are all BPA-free and free of harmful phthalates. The bite valve is medical-grade silicone for long life and taste-free performance. The straw is made of polyethylene, the same material used in milk jugs.
Why stainless steel and not aluminum? When we design a product we look for the best material to satisfy customer requirements. For metal bottles, consumers tell us they prefer the durability and purity of stainless steel. Aluminum bottles have to be made with an inner coating or liners—often with undisclosed ingredients—to protect the metal, which isn't required on a stainless steel bottle. Stainless steel is also stronger, harder and more scratch resistant than aluminum, making a more durable long-lasting bottle for all your adventures.
What is vacuum insulation and how is it made? To make our Insulated .5L bottle we first construct an inner and outer bottle which are sealed together and welded shut to be completely air-tight. Then the bottle is connected to a high-power vacuum pump which removes all the air from the gap in between the inner and outer bottle. Since there's nothing to conduct heat across the gap, vacuum insulation is more effective than foam or other common insulating materials. Vacuum insulation works so well, it is the technology of choice for cryogenic storage tanks and other high-performance insulating vessels. Our vacuum insulated bottle can keep your beverages cool for hours.
(based on 11 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Best Uses
Most Liked Positive Review
Great Insulated Bottle!
Thanks to the people at Camelbak I had the chance to give the Camelbak Stainless Steel Eddy bottle a go and I am now a fan for life. Whether you are on the go...Read complete review
Thanks to the people at Camelbak I had the chance to give the Camelbak Stainless Steel Eddy bottle a go and I am now a fan for life. Whether you are on the go or just relaxing at home, the Eddy is a great bottle. I tend to be on the clumsy side, so I use this bottle in place of a glass on my bedside table at night. With the no spill bite valve, there is no problem if you knock it over while fumbling for a drink or if you drop while you're on a hike. Since it's insulated stainless steel, breaking this bottle is pretty much impossible. The bite valve takes a little getting used to, but the flip down design is nice if you like a little added protection from dust and dirt while outdoors without the inconvenience of an easy to lose cap. The loop on the lid is great for carrying but you don't really need it unless you plan to hook it on your backpack. The bottle is cool to the touch but doesn't "sweat". The insulation does the job and keeps water cool for hours on end. This is a great bottle. The only downside would be that it isn't suitable for hot beverages. 4.5 out of 5 stars*Disclosure: I received a complimentary bottle from the company. I was not required to write a postitive review.*
Most Liked Negative Review
Misleading bottle description
Recently I found that CamelBak started to make bottles from stainless steel. In hope that this one will not smell I bought this bottle. In the section "Product Specification" is written...Read complete review
Recently I found that CamelBak started to make bottles from stainless steel. In hope that this one will not smell I bought this bottle. In the section "Product Specification" is written "Bottle Material: BPA-Free 302 Stainless Steel". And how I was surprised when after I got it on and opened, I revealed that bottle material has plastic upper. Please see attached photo. I don't have a problem with plastic but in this case, like in previous bottle, this plastic produces strong plastic smell - exactly the thing that I tried to avoid when purchased stainless steel bottle. May you please answer questions below.What is a material of plastic part? Why on the site is not written that a bottle has also plastic part besides stainless steel? Why on the site written "Naturally 100% BPA-Free, taste-free stainless steel. No inner liners or plastic coatings that aluminum bottles require." but in reality it has plastic?Thanks.
Reviewed by 11 customers
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My favorite water bottle!
By Lissa
from Asheville NC
Comments about CamelBak eddy™ Stainless Insulated .5L:
I am a teacher and I drink water all day. I hate tepid water so I like to fill up with ice in the morning and keep adding water all day. I have five camelbak eddys and this is by far the best because I can literally leave ice in there for OVER 24 HOURS and it's still frozen the next day! I just wish I could get a larger insulated stainless one! The plastic ones are great too but they don't keep the ice as cold. I love these because they don't sweat on my desk.
By CorvetteGuy1990
from PA
Great bottle...for a while
By College Student Lauren
from Selinsgrove, PA
Walking around campus, a camelbak is an absolute must-have. They never leak, and involve no twisting to open. Brilliant engineering. I justified treating myself to the high-quality bottle since it's MUCH better for the environment than bottled water. I used the bottle as directed, and only used it for cool water (no juice, coffee, etc.) I even washed it by hand. I'm sad to say that after a year of use, there's severe rusting on both the upper rim and inside bottom of the bottle. Consequently, the water from it is undrinkable. I still love camelbaks, so I bought another one (this time, plastic!) but I really hope this lasts more than a year. I wouldn't suggest the stainless steel to anyone looking for a long-lasting bottle, because mine rusted even with a lot of precaution. Perhaps most of the positive reviews have not used the bottle long enough to experience this. Go for the plastic!
(4 of 7 customers found this review helpful)
By Alex
from Israel
(2 of 2 customers found this review helpful)
Best insulated water bottle!
By MystikStar
from Woodland hills, CA
Great water bottle. The thing I love most about it, is that you can put ice cubes in it at night before going to bed and the water will still have some ice in the morning! It remains refreshing through out the night! I also like to take it to the gym with me! Great product
(1 of 1 customers found this review helpful)
Best Water Bottle Ever
By Tracy
from Chicago, IL
I got this water bottle for christmas 2 years ago and still use it today! If I put ice in it in the morning, the ice will still be there at night. My water is cold for days! Definitely a great purchase!
camelbak eddy stainless steel
By missvicm
from gilbert AZ
I am now drinking plenty of water, nice cold water as the eddy keeps the water cold for a day and a half but it gets refills constantly. I was s given this by a friend who was concerned about my hydration. Nice to have friends who care! I'm buying one for my daughter as she can't keep her hands off mine. Her plaustic bottle sweats all over her backpack. Makes a great gift.
The one water bottle I refuse to lose
By Peegan
from Atlanta
I was given this as a gift when I was pregnant and constantly carting a bottle of what always quickly became warm water around. A friend gave me one swearing it would keep my water cold all day. She was right and it has become my constant companion.It is a good size, easy to carry and pretty much goes everywhere with me.
I am participating in a ...
By Ted Williams
from Undisclosed
I am participating in a cardiac rehab program and my advisor tells me that I need to concentrate on hydration, as I am exibiting a few signs of dehydration. I purchased the Stainless Eddy 16oz, and it is with me nearly all day. I am consuming a minimum of 32 ounces daily, and this bottle is perfect! I put in three or four ice cubes and the water is chilled to the last drop. I like this thing. Thanks for a quality product.
One of the best purchases ...
By Julia
One of the best purchases I have made. Though I wish that it held more water. It will keep ice from melting overnight. I love it!


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Speed skating and women's ice hockey were some of the sports showcased during the second day of the Vancouver Olympics.
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Datapalooza, the Data Navigator, and more
Niall Brennan, director for Policy and the Data Analytics Group at the Centers for Medicare and Medicaid Services will talk about how to process large volumes of data.
April 17, 2012
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Gourmet Burgers
4 (5 oz.) Gourmet Burgers 571WZCReg. $33.99 I Now Only $10.99 |
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Resort Reservations 800.832.5665
After all, no mere hotel room could lure you away from the gorgeous James River scenery at Kingsmill. No. Something more was required in order to tempt you away from the grounds, the golf, the spa, and the sumptuous dining.
Each of the recently updated 425 guest rooms and suites at Kingsmill Resort is villa-style, and comfort-inspired, featuring stylish yet comfy furnishings, soft and luxuriant linens, and immaculate bathrooms. We'll even provide you with a plush natural cotton robe during your stay to make sure you stay warm and snug.
And while standard guest rooms are anything but standard, should you wish to make your stay even more memorable, might we suggest a 1, 2 or 3-bedroom suite. Choose from a James River, Warham's Pond, Golf Course or Tennis Center view, all with proximity to both our fitness center, the marina and the Spa at Kingsmill.
We are proudly compliant with ADA standards, with rooms and suites available upon request for any persons with disabilities.


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text: "This is a very exciting program for me. And I'll bet it will get you excited too. The Atkins Chef Recipes program proves you can cook and enjoy virtually any cuisine and still reach all your weight-loss and weight-maintenance goals. With this program, you'll make Atkins-friendly eating more interesting, varied and delicious than ever before. And that's saying something—because for 11 years, I've enjoyed the incredible taste and variety of Atkins. I guess this program proves the best really can get better."


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Bringing Families Together
O, The Oprah Magazine | From the April 2006 issue of O, The Oprah Magazine
Jasmine and John with daughters Jesse and Mackenzie For this family, a cultural divide opened up at the dinner table. "Chinese people often eat family-style—big plates with everyone picking up food with chopsticks," says Jasmine, O, The Oprah Magazine's executive fashion editor. Her husband, a stage-lighting technician, was raised by a strict Welsh mother and Scottish father who belonged to the "clean plate" club. So when their daughters (now 15 and 8) asked for food from their mother's plate, John said, "Not till you finish what's in front of you." After 25 years together and a slew of dinnertime compromises, Jasmine says of her husband, "I have always loved John's spirit. He has his own ideas about everything, from society to work to money. I didn't marry a 'European' man. I married a man who can think for himself." |


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Merck 3Q profit up 2 pct despite sales decline
Topics: From the Wires, News
Drugmaker Merck & Co. said Friday that third-quarter profit rose 2 percent as lower spending and taxes, plus sales growth for several key medicines, offset new generic competition slashing sales for its top-selling drug, Singulair.
The maker of diabetes pill Januvia beat Wall Street's profit expectations by 2 cents. The company also narrowed its 2012 profit forecast to a range of $2.08 to $2.24 per share, from $2.04 to $2.30.
Merck, based in Whitehouse Station, N.J., said net income was $1.73 billion, or 56 cents per share. That was up from $1.69 billion, or 55 cents per share, a year earlier.
Excluding acquisition, integration and restructuring charges totaling $1.2 billion, net income was $2.93 billion, or 95 cents per share.
Revenue was $11.5 billion, down 4 percent. Analysts expected $11.57 billion. Unfavorable exchange rates lowered revenue by 4 percent.
Merck shares dipped a penny, to $46.29, in morning trading.
Sales of asthma and allergy pill Singulair, which brought Merck $5.5 billion last year, dove 55 percent to $602 million. Its U.S. patent expired on Aug. 3 and multiple generic rivals immediately hit the market. Prescriptions for Singulair filled in the U.S. dropped by 90 percent in just the first month.
Despite that, Merck met its pledge to keep total revenue at or near last year's level, excluding the effects of unfavorable currency exchange rates, CEO Kenneth Frazier told analysts during a conference call.
He credited strong global sales of key existing drugs and some new ones, along with sales jumping 15 percent in emerging markets such as China and India, excluding currency effects.
"Our results this quarter reflect the continuing momentum of our underlying business," Frazier said.
He said the company has been launching new consumer and animal health products, expanding sales into more countries and managing its spending while investing for future growth.
Emerging markets — a key growth area for large drugmakers — produced about 20 percent of prescription drug revenue. But recent price cuts in Japan, and continuing pricing pressure from cash-strapped European government health programs, reduced revenue.
Like nearly all big drugmakers, Merck has recently been hurt by new generic competition to a top seller, as patients and insurance plans defect almost overnight to the much-cheaper copycat drugs. But Merck has fared better than most, with only a small drop in total revenue and slightly higher profit.


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Wolfdog tells you how to get/give a raise!
by Dan StoneGood advice from the dog boss ~ Dan
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by AbbyBlake Shelton says he likes to "poke the bear" when talking about his wife Miranda Lambert. He says that she is the easiest person ...
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by Kelly MeyerGet the story here.
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Article Information
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- The Molecular Basis of Thrombin Allostery Revealed by a 1.8 Å Structure of the "Slow" Form
The Molecular Basis of Thrombin Allostery Revealed by a 1.8 Å Structure of the "Slow" Form
Structure, Volume 11, Issue 4, 1 April 2003, Pages 469-479
James A. Huntington and Charles T. Esmon
SummaryThrombin participates in its own positive and negative feedback loops, and its allosteric state helps determine the hemostatic balance. Here we present the 1.8 Å crystallographic structure of S195A thrombin in two conformational states: active site occupied and active site free. The active site-occupied form shows how thrombin can accommodate substrates, such as protein C. The active site-free form is in a previously unobserved closed conformation of thrombin, which satisfies all the conditions of the so-called "slow" form. A mechanism of allostery is revealed, which relies on the concerted movement of the disulphide bond between Cys168 and 182 and aromatic residues Phe227, Trp215, and Trp60d. These residues constitute an allosteric switch, which is flipped directly through sodium binding, resulting in the fast form with an open active site.
Summary | Full Text | PDF (597 kb) - Thymic Selection by a Single MHC/Peptide Ligand
Thymic Selection by a Single MHC/Peptide Ligand
Immunity, Volume 10, Issue 1, 1 January 1999, Pages 83-92
Dong-Sup Lee, Curie Ahn, Bettina Ernst, Jonathan Sprent and Charles D Surh
SummaryIn H2-M− mice, the presence of a single peptide, CLIP, bound to MHC class II molecules generates a diverse repertoire of CD4+ cells. In these mice, typical self-peptides are not bound to class II molecules, with the result that a very high proportion of H2-M− CD4+ cells are responsive to the various peptides displayed on normal MHC-compatible APC. We show here, however, that such "self" reactivity is controlled by low-affinity CD4+ cells. These cells give spectacularly high proliferative responses but are virtually unreactive in certain other assays, e.g., skin graft rejection; responses to MHC alloantigens, by contrast, are intense in all assays. Possible explanations for why thymic selection directed to a single peptide curtails self specificity without affecting alloreactivity are discussed.
Summary | Full Text | PDF (219 kb) - Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokina...
Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator
Chemistry & Biology, Volume 7, Issue 4, 1 April 2000, Pages 299-312
Bradley A Katz, Richard Mackman, Christine Luong, Kesavan Radika, Arnold Martelli, Paul A Sprengeler, Jing Wang, Hedy Chan and Lance Wong
SummaryIntroduction: Urokinase-type plasminogen activator (uPA) is a protease associated with tumor metastasis and invasion. Inhibitors of uPA may have potential as drugs for prostate, breast and other cancers. Therapeutically useful inhibitors must be selective for uPA and not appreciably inhibit the related, and structurally and functionally similar enzyme, tissue-type plasminogen activator (tPA), involved in the vital blood-clotting cascade.Results: We produced mutagenically deglycosylated low molecular weight uPA and determined the crystal structure of its complex with 4-iodobenzo[b]thiophene-2-carboxamidine (Ki=0.21 ± 0.02 μM). To probe the structural determinants of the affinity and selectivity of this inhibitor for uPA we also determined the structures of its trypsin and thrombin complexes, of apo-trypsin, apo-thrombin and apo-factor Xa, and of uPA, trypsin and thrombin bound by compounds that are less effective uPA inhibitors, benzo[b]thiophene-2-carboxamidine, thieno[2,3-b]pyridine-2-carboxamidine and benzamidine. The Ki values of each inhibitor toward uPA, tPA, trypsin, tryptase, thrombin and factor Xa were determined and compared. One selectivity determinant of the benzo[b]thiophene-2-carboxamidines for uPA involves a hydrogen bond at the S1 site to OγSer190 that is absent in the Ala190 proteases, tPA, thrombin and factor Xa. Other subtle differences in the architecture of the S1 site also influence inhibitor affinity and enzyme-bound structure.Conclusions: Subtle structural differences in the S1 site of uPA compared with that of related proteases, which result in part from the presence of a serine residue at position 190, account for the selectivity of small thiophene-2-carboxamidines for uPA, and afford a framework for structure-based design of small, potent, selective uPA inhibitors.
Summary | Full Text | PDF (637 kb) - …more
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Copyright © 1996 Elsevier Science Ltd All rights reserved.
Structure, Volume 4, Issue 11, 1353-1362, 15 November 1996
Research Article
Enzyme flexibility, solvent and 'weak' interactions characterize thrombin–ligand interactions: implications for drug design
Richard A Engh1, *, Hans Brandstetter2, Gudrun Sucher3, Andreas Eichinger3, Ulrich Baumann4, Wolfram Bode3, Robert Huber3, Thomas Poll5, Rainer Rudolph6 and Wolfgang von der Saal5
1 Max-Planck-Institut für Biochemie, D82152, Martinsried, Germany e-mail: email@example.com
2 Max-Planck-Institut für Biochemie, D82152, Martinsried, Germany Department of Chemistry, MIT, 77 Massachusetts Avenue, Cambridge MA 02139, US
3 Max-Planck-Institut für Biochemie, D82152, Martinsried, Germany
4 Max-Planck-Institut für Biochemie, D82152, Martinsried, GermanyThe Institute of Cancer Research, Cotswold Road, Sutton SM2 5NG, UK
5 Boehringer Mannheim GmbH, Sandhofer Str. 116, D68305, Mannheim, Germany
6 Boehringer Mannheim GmbH, Nonnenwald 2, D82372, Penzberg, GermanyMartin Luther Universität, Halle-Wittenberg Institut für Biotechnologie, 06120, Halle Germany
- Background The explosive growth in the rate of X-ray determination of protein structures is fuelled largely by the expectation that structural information will be useful for pharmacological and biotechnological applications. For example, there have been intensive efforts to develop orally administrable antithrombotic drugs using information about the crystal structures of blood coagulation factors, including thrombin. Most of the low molecular weight thrombin inhibitors studied so far are based on arginine and benzamidine. We sought to expand the database of information on thrombin-inhibitor binding by studying new classes of inhibitors.Results We report the structures of three new inhibitors complexed with thrombin, two based on 4-aminopyridine and one based on naphthamidine. We observe several geometry changes in the protein main chain and side chains which accompany inhibitor binding. The two inhibitors based on 4-aminopyridine bind in notably different ways: one forms a water-mediated hydrogen bond to the active site Ser195, the other induces a rotation of the Ser214–Trp215 peptide plane that is unprecedented in thrombin structures. These binding modes also differ in their 'weak' interactions, including CH–O hydrogen bonds and interactions between water molecules and aromatic π-clouds. Induced-fit structural changes were also seen in the structure of the naphthamidine inhibitor complex.Conclusions Protein flexibility and variable water structures are essential elements in protein–ligand interactions. Ligand design strategies that fail to take this into account may overlook or underestimate the potential of lead structures. Further, the significance of 'weak' interactions must be considered both in crystallographic refinement and in analysis of binding mechanisms.


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Michael Kirk - Adjunct Professor | ||
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Michael KirkAdjunct ProfessorFine Arts email@example.com (718) 636-3634 Brooklyn Campus South Hall 1 |
Course Listing14/SP-PRNT-211-07 Silkscreen I 14/FA-PRNT-211-07 Silkscreen I 14/SP-PRNT-212-04 Relief I 14/SP-PRNT-212-03 Relief I 14/FA-PRNT-212-04 Relief I EducationB.A., Rutgers University, State University o; BiographyMichael Kirk is an artist and master printmaker. His works have been exhibited at Gimpel and Weitzenhoffer Gallery in NYC; Cork Gallery in Avery Fisher Hall, Lincoln Center; The Print Club, Philadelphia, PA; Instituto Cultural Peruano Norteamericano, Lima, Peru; Norske Grafikere, Oslo, Norway and many other national and international venues. He is in the collections of The Brooklyn Museum; Philadelphia Museum of Art; Library of Congress, Smithsonian Institute; National Museum of Art; Colgate University; University of Minnesota; Penn State University; University of Wyoming; Municipal Council, Moracado, Venezuela. Kirk has received fellowships from New York Foundation for the Arts and the ED Foundation and residencies at Au Fort, Cameret Sur Mer, France and Kunstnerhuset, Lofoton, Norway. He also teaches printmaking for Parsons The New School for Design within the school of Art Media and Technology. |


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Richard Estes Catalogue
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Chase, Linda. "Interviews with Robert Bechtie, Tom Blackwell, Chuck Close, Richard Estes and John Salt,"
OPUS International,
June, 1973, pp.38-50.
John Arthur,  Richard Estes,  "A Conversation,"
Museum of Fine Arts, Boston and the New York Graphic Society,
Arthur, John. "Richard Estes: Interview on his Graphics,"
Print Collector�s Newsletter,
Arthur, John. "Conversation with Richard Estes,"
Architectural Digest,
October, 1982.
Arthur, John. "Richard Estes Interview,"
Archives of American Art, Smithsonian Institution,
October 20, 1985.
Jillian Slonim,  Richard Estes,  "The Art of the Print: Richard Estes,"
American Federation of the Arts,
Autumn, 1992.
Peterson, Gregory J. "Richard Estes,"
August 2, 2002.


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The Story of Rett Syndrome: From Clinic to Neurobiology Neuron, Volume 56, Issue 3, 8 November 2007, Pages 422-437 Maria Chahrour and Huda Y. Zoghbi Summary The postnatal neurodevelopmental disorder Rett syndrome (RTT) is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2), a transcriptional repressor involved in chromatin remodeling and the modulation of RNA splicing. MECP2 aberrations result in a constellation of neuropsychiatric abnormalities, whereby both loss of function and gain in MECP2 dosage lead to similar neurological phenotypes. Recent studies demonstrate disease reversibility in RTT mouse models, suggesting that the neurological defects in MECP2 disorders are not permanent. To investigate the potential for restoring neuronal function in RTT patients, it is essential to identify MeCP2 targets or modifiers of the phenotype that can be therapeutically modulated. Moreover, deciphering the molecular underpinnings of RTT is likely to contribute to the understanding of the pathogenesis of a broader class of neuropsychiatric disorders. Summary | Full Text | PDF (812 kb) |
Dosage-Dependent Severity of the Phenotype in Patients with Mental Retardation Due to a Recurrent Copy-Number Gain at Xq28 Mediated by an Unusual Recombination The American Journal of Human Genetics, Volume 85, Issue 6, 11 December 2009, Pages 809-822 Joke Vandewalle, Hilde Van Esch, Karen Govaerts, Jelle Verbeeck, Christiane Zweier, Irene Madrigal, Montserrat Mila, Elly Pijkels, Isabel Fernandez, Jürgen Kohlhase, Christiane Spaich, Anita Rauch, Jean-Pierre Fryns, Peter Marynen and Guy Froyen Abstract We report on the identification of a 0.3 Mb inherited recurrent but variable copy-number gain at Xq28 in affected males of four unrelated families with X-linked mental retardation (MR). All aberrations segregate with the disease in the families, and the carrier mothers show nonrandom X chromosome inactivation. Tiling Xq28-region-specific oligo array revealed that all aberrations start at the beginning of the low copy repeat LCR-K1, at position 153.20 Mb, and end just distal to LCR-L2, at 153.54 Mb. The copy-number gain always includes 18 annotated genes, of which RPL10, ATP6AP1 and GDI1 are highly expressed in brain. From these, GDI1 is the most likely candidate gene. Its copy number correlates with the severity of clinical features, because it is duplicated in one family with nonsyndromic moderate MR, is triplicated in males from two families with mild MR and additional features, and is present in five copies in a fourth family with a severe syndromic form of MR. Moreover, expression analysis revealed copy-number-dependent increased mRNA levels in affected patients compared to control individuals. Interestingly, analysis of the breakpoint regions suggests a recombination mechanism that involves two adjacent but different sets of low copy repeats. Taken together, our data strongly suggest that an increased expression of GDI1 results in impaired cognition in a dosage-dependent manner. Moreover, these data also imply that a copy-number gain of an individual gene present in the larger genomic aberration that leads to the severe MECP2 duplication syndrome can of itself result in a clinical phenotype as well. Abstract | Full Text | PDF (1809 kb) |
This Month in the Journal The American Journal of Human Genetics, Volume 77, Issue 3, 1 September 2005, Pages i-ii Kathryn Garber and Robin E. Williamson Full Text | PDF (131 kb) |
Copyright © 2005 The American Society of Human Genetics All rights reserved.
The American Journal of Human Genetics, Volume 77, Issue 3, 442-453, 1 September 2005
Hilde Van Esch1, *, , , Marijke Bauters2, *, Jaakko Ignatius3, Mieke Jansen2, Martine Raynaud4, Karen Hollanders2, Dorien Lugtenberg5, Thierry Bienvenu6, Lars Riff Jensen7, Jozef Gécz8, 9, Claude Moraine4, Peter Marynen2, Jean-Pierre Fryns1 and Guy Froyen2
1 Centre for Human Genetics, University Hospital Gasthuisberg, Leuven, Belgium
2 Human Genome Laboratory, Centre for Human Genetics, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
3 Department of Clinical Genetics, Oulu University Hospital and Oulu University, Oulu, Finland
4 Centre Hospitalier Universitaire de Tours, Service de Génétique, Tours, France
5 Department of Human Genetics, University Medical Centre, Nijmegen, The Netherlands
6 Université Paris-Descartes, Faculté de Médecine, INSERM, Centre National de la Récherche Scientifique, Institut Cochin, Paris
7 Max Planck Institute for Molecular Genetics, Berlin
8 Department of Genetic Medicine, Women's and Children's Hospital, Adelaide, Australia
9 Department of Paediatrics, University of Adelaide, Adelaide, Australia
Loss-of-function mutations of the MECP2 gene at Xq28 are associated with Rett syndrome in females and with syndromic and nonsyndromic forms of mental retardation (MR) in males. By array comparative genomic hybridization (array-CGH), we identified a small duplication at Xq28 in a large family with a severe form of MR associated with progressive spasticity. Screening by real-time quantitation of 17 additional patients with MR who have similar phenotypes revealed three more duplications. The duplications in the four patients vary in size from 0.4 to 0.8 Mb and harbor several genes, which, for each duplication, include the MR-related L1CAM and MECP2 genes. The proximal breakpoints are located within a 250-kb region centromeric of L1CAM, whereas the distal breakpoints are located in a 300-kb interval telomeric of MECP2. The precise size and location of each duplication is different in the four patients. The duplications segregate with the disease in the families, and asymptomatic carrier females show complete skewing of X inactivation. Comparison of the clinical features in these patients and in a previously reported patient enables refinement of the genotype-phenotype correlation and strongly suggests that increased dosage of MECP2 results in the MR phenotype. Our findings demonstrate that, in humans, not only impaired or abolished gene function but also increased MeCP2 dosage causes a distinct phenotype. Moreover, duplication of the MECP2 region occurs frequently in male patients with a severe form of MR, which justifies quantitative screening of MECP2 in this group of patients.


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Steroid-Induced OsteoporosisTopic OverviewMany people take oral or inhaled steroids, which include prednisone, betamethasone, and fluocinolide, for conditions such as asthma or chronic obstructive pulmonary disease (COPD). Oral steroids and high-dose inhaled steroids can cause bone loss over time. If you are on these types of medicines for 6 months or longer, you are at increased risk of developing osteoporosis, which puts you at high risk for broken bones. Once broken bones occur, healing can take a long time because of the decreased ability of your bones to rebuild due to osteoporosis. If you are on long-term use of steroids, you should be monitored for bone loss. Related InformationCredits
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Molly Weisman
Transfer Specialist
Email Address: email@example.com
Phone: 773-442-4076
Fax: 773-442-4066
About Molly Weisman:Molly Weisman is the Transfer Enrollment Specialist and is responsible for providing transcript evaluations for prospective students as well as assisting with course selection at the students' current institution. Molly completed her Bachelor Degree in Sociology with a minor in Social Work at Northeastern Illinois University after transferring from both University Of Illinois Urbana and Wright Community College.
"Transferring to and graduating from Northeastern Illinois University gives me firsthand experience with what students are looking for in their education experience. Working closely with admissions staff and transfer students, I hope to make students' journeys as smooth and seamless as possible."


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Hi guys due to an unfortunate stock issue I have to settle for the white ipad 2 instead of the black I wanted. Originally I was going to get the black leather smart cover but now I'm worried about the colors clashing. Im now thinking about now either the navy, beige or the black cover.
Any recommendations? Do you still think the Black will be okay?


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City Walks
Cape Town's central area is quite compact when compared to other great cities of the world – and experiencing its urban culture on foot is a fantastic way to experience the city.
Start off at the Castle of Good Hope (+27 21 464 1264; www.iziko.org.za/museums/william-fehr-collection-at-the-castle-of-good-hope) and if you have the time – enjoy a guided tour of the castle.
West of the Castle (on the corner of Darling and Buitenkant Streets) you'll find the Grand Parade – where Nelson Mandela made his first memorable speech after being released after 27 years of imprisonment under apartheid. Cape Town's City Hall overlooks the Grand Parade. Built in 1905, it was the last major Victorian building to be erected in Cape Town.
Keep walking to the top of Adderley Street where you'll find the Company's Gardens. Here, you'll find Cape Town's Cultural History Museum originally built as a slave lodge. Today, it's a fascinating museum – and the reconstructed tombstone of Jan Van Riebeeck can be found in the courtyard.
Walk up Government Avenue, this pedestrian walkway is lined with oak trees. Stop over at the South African National Art Gallery (+27 (0)21 467 4660;http://www.iziko.org.za/museums/south-african-national-gallery) with its displays of over 6 500 works of art by some of South Africa's best-known artists and their international counterparts.
As you walk through the Gardens you'll see the Memorial to South African soldiers killed at Delville Wood, as well as various notable statues, monuments and fountains.
At the top of the Gardens you'll find the South African Museum – with some of the pieces on display dating back 117 000 years. Next door is the Once you've visited the Nellie, return to the city centre via Long Street where you can enjoy the shops or stop for a light meal – Long Street Café (+27 21 424 2464) offers a varied menu and coffee. If shopping is on your mind then a visit to Greenmarket Square is a must.
There are also walks around Table Mountain and daily walks at Kirstenbosch National Botanical Gardens. To stretch your legs, the Sea Point promenade is a wonderful place for a long walk with the ocean next to you.
Did you know?
According to StatsSA, greater Cape Town had a population of 3.5 million in 2007.
Extra info
Contact Cape Town Tourism for more information.
Proudly Macassar Pottery
Proudly Macassar Pottery is a social enterprise, situated in an old tavern building in Macassar, Cape Town. We use the production of clay UDU drums and flutes to create a space for at-risk youths from the surrounding community to discover themselves and a purposeful, sustainable and economically empowered lifestyle.
Learn to cook like a local in the Bo-Kaap
If you're keen on spending some time in the kitchen, book yourself on a cooking safari and learn to cook secret recipes from one of the local Bo-Kaap ladies in her very own kitchen. This activity is a must-do for any foodie or those interested in getting to know the Cape Malay culture.
Gourmet Cape Town
It's no surprise that Cape Town is considered the gourmet capital of Africa – nine of the country's top 10 restaurants, as voted in the 2011 Eat Out DStv Food Network Restaurant Awards, are found in Cape Town and Cape winelands.
Walking in Cape Town
Many visitors want to explore nature on higher ground as soon as they arrive in Cape Town and with Lion's Head and Table Mountain beckoning, many do get to experience the local flora and fauna on foot. However, the entire peninsula can be enjoyed by avid walkers. From Blouberg Beach, with its picture perfect views from its sandy shores, to the more adventurous guided Hoerikwaggo Trails along the spine of Table Mountain, visitors have an expanse of ground to cover.
Cape Town labyrinths
Labyrinths are a common element in many different cultures, with earliest records dating back 3 500 years.
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Tips on Responding to Essay Questions
Major/Goals Describe why you selected your major area of study and your future academic and career goals. Express what you want to do professionally and personally with your life (maximum of 300 words).
Adversity/Challenges Describe any adversity or challenges you have overcome and continue to face in your pursuit of your educational goals (maximum of 500 words).


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Wednesday, January 11, 2012
2 comments:
- rob lafleurJanuary 13, 2012 at 12:12 AM
you are doing some incredible work, john. be proud of this blog!
I would appreciate any comments or feedback. If you are a (distant) cousin just finding our connection, leave a message and a way to contact you to share information. God bless all.
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Pop-Up Bottle Opener
Price: $56.00Design by Giovanni Alessi Anghini. To use, push down on the bottle cap remover. A magnet inside holds onto the metal cap once it has been removed from the bottle neck. Read More
Design by Giovanni Alessi Anghini. Giovanni Jr. is the son of Alessio, grandson of Carlo and great-grandson of Giovanni, founder of Alessi. Like a number of his fourth-generation cousins, he makes a point of using both of the family surnames: Alessi Anghini. After a period at Stefano Giovannoni's studio in Milan, Giovanni Jr. is taking his first steps in the designer's profession. A short while ago he presented this bottle opener to Alessi featuring a pressure opening mechanism, an ingenious idea in this his "opus one", that they were happy to develop and put into production. To use, push down on the bottle cap remover. A magnet inside holds onto the metal cap once it has been removed from the bottle neck.
Material(s): Stainless steel mirror polished and thermoplastic resin
Dimensions: H 3.705" Dia 3.12"
Designer: Giovanni Alessi Anghini
Giovanni Alessi Anghini was born in Milan. He spent his early years as a student in German-speaking Switzerland, often travelling to the UK and the US. Having studied Anthropology and Sociology at Florence University, he moved to Milan to study Industrial Design at the European Design Institute. Here, he worked for two years as a designer in Stefano Giovannoni's studio. He has been working freelance since 2006. He currently lives and works on Lake Maggiore.
View other products by Giovanni Alessi AnghiniManufacturer: Alessi
Alessi. Art and Poetry.
Alessi is a family owned Italian design company, founded in 1921. Giovanni Alessi, a talented sheet metal worker, produced items by hand for the table and home out of copper, brass and nickel-silver. He was later joined by his son Carlo who was responsible for many of the designs produced in the 1930s and early 1940s. In the mid 1940s Alessi began to work with outside designers. The current Alessi catalog is the result of a collaboration with over 500 designers from all over the world.
"A true work of design must be able to move people, to convey feelings, to trigger memories, to surprise, to go against the grain. From this point of view, design intended to conjure up images in people's minds, which makes them a bit happier, still has tremendous potential." — Alberto Alessi
View other products from Alessi


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Factory Direct Pricing - Save up to 30%!
FREE Art Prep & Design - $50 Savings! More details
Connect with us and get marketing tips to enhance and build your brand.
"Just ordered these cubes. " -Maria T., Catalina Foothills
"I ordered the new year cards to send to all my old clients and staff. " -Jacob P, Madison
"These media cases are so good. " -Marshall S., Blue Springs


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2010-12-19, 11:22 | Link #1 |
Junior Member
Join Date: Dec 2010
Whither Nyaatorrents
I have been trying to access NyaaTorrents for the last 3 days and have not had any luck. Any word on what is happening?
On the few occasions where I have gotten the site to come up, I can get the main page, but links, refreshes of the page, or going to the next page all bring back page not found messages. |
2010-12-20, 11:20 | Link #2 |
Also a Lolicon
Join Date: Apr 2010
nyaatorrents loads slowly for me, but still works all the time
If its not loading at all, it might be a problem on your end when you try to click a link or something, does something like this show up? or can you not get to the server? or do you get a DNS error? |
2010-12-23, 07:47 | Link #3 |
Giga Drill Breaker
Join Date: Jan 2009
you can also try changing your DNS to google public DNS here is how http://code.google.com/speed/public-dns/docs/using.html
2011-01-24, 12:22 | Link #5 |
Join Date: Dec 2007
Location: The wonderful country of Finland^^
Could have been routing issues somewhere. Last few days I had very slow loads of some sites, like for example, AniDB, while others worked normally.
Depending on your location the sites affected would differ. It's back to normal now for me at least, so @ragnar does nyaa load now? |
Thread Tools | |


text: Martinsburg council adopts budgetMarch 27, 2013MARTINSBURG — At a special meeting Tuesday, Martinsburg City Council members unanimously approved a nearly $30 million budget for the fiscal year that begins July 1.... Majoritarian"coal severance tax is distributed by the state to all counties and municipalities in WV...majority of the revenues goes to jurisdictions where coal is produced, and the balance ...the remaining jurisdictions" To make up for less coal severance tax,... air quality program was lowered by $1,525." They sure dont mind taken a lil skim from the same industry they try to put out of business. Yeh, real principled lot. If they arent trying to limit markets that private business need to expand into the Eco people then whine that rates are too high. You caused it! Now where are them Magic power sourced? 0 Agrees | 1 Disagrees | Report Abuse » Showing 1 of 1 comments


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Radcliffe sports an interesting new do at an awards show in London. Plus: Ellen Page, Reese Witherspoon & more!
Credit: Anthony Devlin/PA/Landov
Published: Monday Feb 24, 2014 | 07:00 PM EST
More from PEOPLE
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Showing off his full head of hair, Daniel Radcliffe has plenty to celebrate after picking up honors for best actor in a play at Sunday's WhatsOnStage Awards in London.


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Sorel Women's Tivoli Boot
The Sorel Women's Tivoli Boot is a tried and true favorite that provides both outstanding warmth and style. Featuring a waterproof shell lined with 100 grams of Thinsulate, a full-length fleece lining, and a removable EVA footbed for insulation, you and your Tivoli boots can tell the cold weather to bring it on. This women's winter boot uses a molded rubber outsole that was inspired by the 1964 original to provide the traction and stability that has been promised by Sorel for over forty years. Truly a piece that can step up your style, the Sorel Tivoli women's boot is guaranteed to stay at the front of your closet for years to come.
FEATURES of the Sorel Women's Tivoli Boot
- Waterproof shell and waterproof upper membrane
- 100g Thinsulate insulation
- Full length fleece lining
- Molded rubber outsole
SPECIFICATIONS of the Sorel Women's Tivoli Boot
- Weight: 15.5 oz / 440 g
- Shaft Height: 6" / 15 cm
Add Smartwool Hiking Medium Crew Sock to your order
Patagonia Women's Re-Tool Snap-T Pullover $94.99 - $119.00 |
The North Face Women's Denali Jacket $115.99 - $198.95 |
Patagonia Women's Down Sweater $200.00 - $219.00 |
The North Face Women's Osito Jacket $63.99 - $118.95 |
Sorel Women's Joplin Rain Boot $134.95 |
Patagonia Women's Better Sweater 1/4 Zip $99.00 |
The North Face Women's Venture Jacket $73.99 - $98.95 |
Canada Goose Women's Trillium Parka $650.00 |
Sorel Men's Caribou Boot $139.95 |
custy reviews
for the Sorel Women's Tivoli Boot
Average Custy Rating:
(based on 8 reviews)
Viewing All
These can be dressed up or down and they are SUPER CUTE. (plaid) They fit true to size im a 6.5/7 I got a 7 so i can wear extra warm socks with them. They are durable!! unlike some other Sorel boots they have a built in liner which is nice. They are very water proof and not bulky or heavy. I love these with a thick sock (pulled up over skinny jeans) and a big sweater for a casual night out after skiing (my go to look). But its also nice to have a lighter boot, less weight and bulk to lug around. I recommend if you want to be comfy and cute!
Everyone is jealous of my boots because they look super cool!Besides looking cool, they fit perfectly true to size, are super fuzzy and comfy to wear, and do their job as winter boots very very very well.
These boots are everything that i was looking for, they aren't clunky like other sorel boots and they look super cute with your jeans tucked inside or out of the boot. These are perfect fot trecking through the snow on campus. They fit true to size.
These are my first "real" winter boots since I was a small child. At age 35 I decided it was time I embraced the fact that I live in Michigan, having grown tired of cold feet and wet pant bottoms! I was a little nervous.Would I love them?Were they worth a hunderd bucks?Would they make my size 10 feet look huge? Well, I DO love them and they will be my go-to foot wear for anything taking me outdoors, easy on and easy off, so convenient.They keep my pants dry, my feet warm, and make them look cute as a button.I really am very pleased that I bought these, and expect them to last for many winters to come.
i bought some sorel boots last year and liked them so much i had to get these. boot runs true to size for me (I wear an 8). though, i tried the boots with thick socks and they were tight then. i wear these boots at work, while shopping and even when i'm brushing my teeth - they are comfy! i've already received bunches of complements from the haters at work. ;O)
I bought these because lets face it, they are cute, way more so than the "traditional" Sorels. I also liked that they were less clunky. A problem that I found with these boots was that they ran small. I usually wear a 7.5 or an 8, I bought an 8 in these boots and when I put them on they were too tight to be comfortable. Another drawback of these boots is that the liner is not removable like most Sorels, making drying a little more tricky. As a result of not having a removable liner, it gets bunched when you put your fit in and pull it out. I ended up having to get a different pair of boots because these just wouldn't work. My sister lucked out and got these for her smaller feet!
My new boots arrived on my doorstep today. I usually wear a size 8 but ordered up one size and they fit perfectly. I live in Colorado and in preparation for the snow that will be here soon I wanted a boot that would be warm, waterproof, and cute all in one package. The inside is lined and cozy soft as well. I highly reccomend this boot to anyone who needs a nice pair of boots for the winter.
You probably would have looked amazing with it too.
We do have availability on some similar items available right now though. Check out More Sorel Womens Boots


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A collection of news and information related to Bartolo Colon published by this site and its partners.
Top Bartolo Colon Articles
Displaying items 67-77
Mariners Bats Come Alive, Hang on for Sweep in Oakland
Mariners home opener goes flat: Oakland A's blank M's 4-0
Pre-game: Orioles vs. Athletics
Betemit caps Orioles' ninth-inning rally with walk-off homer
Kevin Cowherd: Let's not spoil Orioles' fun by looking ahead to tough stretch
Orioles reliever Pedro Strop's aggressiveness in strike zone building confidence
Story | Apr 30, 2012 | 3:30 AMAs the Orioles went 5-1 on this week's six-game homestand, it's been an eventful week for right-handed reliever Pedro Strop. Earlier this week, with closer Jim Johnson hospitalized with food poisoning, Strop had the opportunity to step into... -
Pirates pack one-two punch with Brennan and Yuhl
Scoreboard -- Nov. 3, 2012
Story | Nov 3, 2012 | 10:23 PM|TV SPORTS| |SUNDAY| NFL Football--Denver Broncos at Cincinnati Bengals, Noon (CBS); Minnesota Vikings at Seattle Seahawks, 3 p.m. (FOX); Pittsburgh Steelers at New York Giants, 3:25 p.m. (CBS); Dallas Cowboys at Atlanta Falcons, 7:20 p.m. (NBC)... -
Roger Clemens: An Annoying Skeeter
Scoreboard: Aug. 23
Story | Aug 23, 2012 | 1:05 AMTODAY HIGH SCHOOL GIRLS' TENNIS Aberdeen Roncalli at Milbank, 1 p.m. TV SPORTS Tennis-WTA New Haven Open, Noon (ESPN2); ATP World Tour, Winston-Salem Open, 3 p.m. (ESPN2), same-day tape, 9 p.m. (ESPN2) Cycling-U.S. Pro Challenge, Stage 4, 3 p.m.... -
Baseball cheaters should get stiffer penalties


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The digital thermometer on the wall of Monroe's Fast Lube and Car Wash in Centralia hovers at 25 degrees.
BOONE LIFE: Frozen assets
Twenty-five degrees: A car washing business hinges on a thermometer
Sunday, February 18, 2007 | 12:00 a.m. CST;
updated 10:51 p.m. CST, Monday, February 9, 2009
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If you'd like to read more about the value of being a member, read this column from the Missourian's executive editor, Tom Warhover.


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This was by far the best show i have seen. Die hard fans would love this show...drinkin, smokin, and having lots of fun...i would totally recomend this show to any of hank the 3rds biggest fans..
Thank you for registering for TicketsNow email alerts. As a first time subscriber, you will receive an email with a 10% discount for use on your first order!


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See updated list of 10 Most Censored Countries at http://cpj.org/reports/2012/05/10-most-censored-countries.php. |
In Togo, journalists are skeptical but see opportunity in the regime's bid to By Adam Posluns with reporting by Alexis Arieff |
With 37 years in power, Togolese President Gnassingbé Eyadéma is Africa's longest-serving head of state. Even after the country introduced multiparty elections more than a decade ago, Eyadéma and his ruling party, Rassemblement du Peuple Togolais (RPT), managed to dominate politics and muzzle opposition voices in this West African nation. The RPT's ironfisted tactics and numerous human rights abuses led the European Union (EU) to suspend cooperation with Togo in 1993. |
On the front lines of international journalism, local fixers face growing dangers, and their western employers face tougher questions. By Elisabeth Witchel
As journalists become targets more often,a reporter finds a bunker mentality taking hold among the press corps.
By P. Mitchell Prothero


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Solomon Pond Mall Trip- March 2
Start Date: March 2, 2013
End Date: March 2, 2013
Time: 3:30 pm to 9:00 pm
Solomon Pond Trip- Saturday, March 2, 2013
Departure from Leicester at 3:30 p.m. (in front of the Fuller Campus Center)
Departure from Worcester at 4:00 p.m. (in front of the Boutin Student Center)
Departure from Solomon Pond mall: 9:00 p.m.
*Please note: the bus will depart at 9:00 p.m., no later*
Enjoy the movies, shops, and restaurants at the Solomon Pond Mall on the following Saturdays this semester: February 2 & March 2, 2013. These trips include free transportation to/from the Solomon Pond Mall.
Space on the bus is limited- first come, first served.
Register online now.
Organized by
Event Categories: All and Student Activities.
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Starts 04/11/2014at 7:00a.m.
Ends 04/11/2014 at 3:00p.m. -
Nurses Pinning Ceremony
Starts 05/10/2014at 3:00pm
Thursday Night Live presents Stump! Trivia Night for Great Prizes
Starts 03/27/2014at 8:00p.m.


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NH Aranzazu is a large hotel, offering plenty of rooms. Rated with 4 stars, this accommodation is certainly higher than average.
Choosing to stay at NH Aranzazu allows you to take advantage of the general facilities on offer here; a bar/lounge and a coffee shop/café are among them. Facilities that are rendered useful are a laundry service and a dry cleaning/laundry service, in addition to a late check-out option. Organising a meeting is possible in one of the meeting rooms. Working during your stay in San Sebastián is more convenient, as you can use a conference space and an audio-visual equipment set here. This San Sebastián hotel has 180 rooms. Paid self service parking at limited hours is another option you can make use of when you come here by car.
In the rooms of NH Aranzazu the temperature can be controlled via air conditioning. For those of us who enjoy convenience, a wake-up service and a daily housekeeping service are included in the rooms of the accommodation. The available wireless high-speed Internet access (complimentary) keeps you connected during your stay in San Sebastián. Some rooms are liberally provided with a pillow menu. Bathrooms are enriched with a bidet and a complimentary toiletries set as well as a rainfall showerhead.
Show reviews
Check-in: | From 15:00 Check-out: Until 12:00 |
Internet: | Wired Internet, Wireless high-speed Internet access (complimentary), Internet Point |
Parking: | Indoor parking, Guarded parking, Paid parking, Parking Nearby, Paid Parking (limited), Paid Parking (Self-service) |
Rooms: | 180 |
Services: |
General facilities: |
Extra common areas: |
Business facilities: |
Wellness facilities: |
Note: It is the responsibility of the hotel chain and/or the individual property to ensure the accuracy of the photos displayed. We are not responsible for any inaccuracies in the photos. | |
Please provide this reference number to our customer service center representative on request, so we can help you better


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- | Order Status | Contact Us: 1-800-892-3622
Arctic Air Two Door Reach In Refrigerator
- Lowest Advertised Price
- $2,089.80
Call or chat online with us during business hours for your priceMon-Fri 9am-6pm Eastern 1-866-217-2530This manufacturer has a minimum advertised price policy
- Sold As
- Packed As
- 1
DescriptionArctic Air Two Door Reach In Refrigerator
List Price: $3,240.00
Arctic Air's AR49 Two door reach in refrigerator is designed to give you real, commercial foodservice grade performance. AR49 as well as all other Artic Air products are tested to NSF Standards. Reach-In model AR49 is beautifully designed in smooth stainless steel. AR49 Reach-In refrigerator includes high output fan motors.
- Electronic Thermostat with external digital display
- Bootom mounted compressor
- Front accessible
- Bottom mounted condensing unit mounted on slide out rack
- 54in W x 32.75in D x 82.75in H
- 2 door
- 6 shelves
- 49 Cubic Feet
- 33F to 41F temp range
- Cord length 9
- NEMA Plug 5-15P
- Weight 455SpecificationsName Arctic Air Two Door Reach In Refrigerator Manufacturer Arctic Air Product ID AII-AR49 Manufacturer ID AR49 Equivalents AR49, AR-49, AR 49, AIIAR49, AII AR49 Material Stainless Steel Product Weight 455 lbs
Arctic Air Two Door Reach In Refrigerator


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Cleveland Fish Fry Guide
Find out where the local Lenten fish fry events are taking place in Cleveland March 5-April 17.
Company has been strong in Ohio for generations
The Root Candle Company of Medina, Oh., has sold its candles around the U.S. The company got its start back in 1869.
Maple Sugar programs
Get weekly updates on select events and activities happening in northern Ohio national, state and county parks.
Cleveland bakery crafting creations since 1903
The beloved packzki, a traditional Polish pastry dating back to the Middle Ages. Here, in one of Cleveland's most traditional…
VIDEO: CLE fire fighters pancake-eating contest
The Cleveland Fire Department got a head start on the celebration of National Pancake Day Monday at the Steelyard Commons IHOP.
Killed in Korean War, soldier returns to NE Ohio
In 1950, U.S. Army Private 1st Class Donald Durfee from Painesville was killed in action during the Korean War.


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Public Information Office 310 Owen Hall, Campus PO 1820 Asheville, NC 28804-8507 828/251/6526 FAX: 828/251-6777 web: http://www.unca.edu/news e-mail: email@example.com |
For Immediate Release January 17, 2001 UNC Asheville's Board of Trustees Unanimously Recommends Tuition Increase; Proposal Moves to UNC Board of Governors The UNC Asheville Board of Trustees today voted unanimously to recommend a three-year tuition increase of $200 per year for review by the University of North Carolina Board of Governors. All funds from the tuition increase would go to enhance the student academic experience, both inside and outside the classroom. The recommendation includes a commitment of funds to cover the full cost of the tuition increase for students who receive need-based financial aid and to expand on-campus work opportunities for students. Forty percent of the increased revenue would go to classroom and instructional support. For example, funds would go to several critically important educational programs, including the Teaching Fellows, the African American Colloquium, the Honors Program and Undergraduate Research. Funds would also be used to purchase scientific equipment, computer software, and other much needed academic equipment. Twenty-five percent of the new funds would be dedicated to student support services, providing increased assistance for students with disabilities, additional career counseling services, expanded multicultural programming, and additional financial aid counseling, as well as the increased funding of on-campus student work opportunities. Thirty-five percent of the funds would be set in a "hold harmless" financial aid pool dedicated to insuring that the tuition increase is covered for all students receiving need-based financial aid. The new funds will be spent on priorities that have been identified in recent years through UNCA's campuswide strategic planning process. Ryan Southern, Student Government Association president, and Kevin Brinson, Student Government Association vice president and a member of the Tuition and Fees Committee, both told the board that UNCA's student body supports the increase. "The Tuition and Fees Committee investigated intensely what the university needed and what the increase should go for. . . . We felt strongly that we needed to put the increase into something that benefits all students -- academics and students life," Brinson said. "Our academics are top notch, but it is clear additional funding is needed. Improving student services is a high priority for any student and for the university as a whole. The Student Government Association unanimously supports this proposal." "The Chancellor has spoken to many of the students about this proposal and where the money would go -- directly to students and academic programs. I feel I can speak for the entire student body to say we support this," Southern said. "We have an excellent institution, but we have to have resources available to sustain it, " said UNCA Chancellor James Mullen. "The board has sent forward this proposal for three basic reasons. First, because it believes that a tuition adjustment will permit a range of learning opportunities that our students deserve and we see as fundamental if we are to stand among America's finest liberal arts colleges. Second, the Board sees the plan as part of a comprehensive funding strategy that also emphasizes the need for additional state funding and builds on the increasing success of UNCA's private fund-raising efforts. Third, the Board recognized the central importance of the plan's strong financial aid component -- a component which holds harmless those students who depend on aid." "The tuition initiative holds outstanding potential to enhance academic and student life at UNC Asheville," said Kevan Frazier, a UNCA alumnus and faculty member. "The proposal is tied to a well-planned implementation program. As such, it will be an effective way to support our academic mission as we continue to offer one of the best liberal arts educations in the nation." Tuition at all UNC campuses is set by the UNC Board of Governors. Campuses may request special increases from the UNC Board of Governors. This is the first time UNCA has pursued such an adjustment. Last year UNC-Chapel Hill, North Carolina State, UNC-Wilmington, East Carolina University and UNC-Charlotte were granted increases. The Board of Governors will consider campus-initiated tuition increases at its March meeting. UNCA's tuition adjustment proposal originated from a unanimous recommendation of the campus Fees and Tuition committee, whose membership included the Student Government Association vice president, several members of faculty and administration, and a representative of the Board of Trustees. The proposal recommends a $200 increase in annual tuition for 2001-2002, an additional $200 for 2002-2003, and a third $200 increment for 2003-2004. Current tuition and fees at UNCA for an instate student total $2,063. UNCA estimates that about $552,000 would be generated by the tuition increase in 2002-2002, $1.10 million in 2002-2003, and $1.7 million in 2003-2004. Every year, 35 percent of the revenue would be set aside to cover the cost of the tuition increase for students who receive need-based financial aid. In addition, funding would be set aside to expand on-campus work opportunities, which often prove more academically beneficial to working students than do off-campus, part-time jobs. Media Contacts:


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Daytime highs this week in Omaha are forecast to be nearly 20 degrees below normal, and overnight temperatures are likely to be about 10 degrees below average.
That's a sharp departure from last year when the warmest March on record was unfolding as hot winds blew in from the south.
A year ago at this time, Omaha was seeing daytime highs ranging from the 60s into the 80s. Nights typically were in the 50s and 60s.
This week, highs are forecast to be generally in the mid-30s with nighttime lows in the upper teens to low 20s.
The average high this time of year is 53 degrees. The low temperature averages 29 degrees.
More than 15,000 high-temperature records were matched or achieved in the United States during March 2012. In Nebraska, 425 such records were matched or set. In Iowa, the number was 1,118.
Sources: National Weather Service; World-Herald archives


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Renters priced out of L.A.
| Mar 9, 2008
Deanna Corbin, 46, would live in Los Angeles if she could. But she can't, at least not with a modicum of space and safety, not on her $38,000 salary as an administrative secretary.
So Corbin gets up at 4 a.m. every day and hustles her 11-year-old...


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Longshore Dispute
6:36 am
Thu December 27, 2012
ILWU Members Say They'll Work Despite No New Contract
The International Longshore and Warehouse Union has decided to show up for work Thursday, despite grain terminal owners sticking fast to their last contract offer — which workers rejected. OPB's Kristian Foden-Vencil reports.
United Grain, Columbia Grain and Louis Dreyfuss notified the ILWU that owners would be implementing the terms of their final offer, 6 o'clock Thursday morning.
In a statement, grain owners spokesman Pat McCormick stressed that union members are welcome on the job, and that there's no lock out.
The ILWU issued its own statement in response, saying members will continue working, despite what it calls the "substandard provisions of the final offer".
Spokeswoman Jennifer Sargent said the union is disappointed owners won't continue to negotiate what she calls 'a fair agreement.'
Grain terminal owners issued a statement Monday saying the impasse is not about wages or benefits. They argue that the union has granted two competing terminals conditions favorable to the owners, such as allowing fewer workers to load ships.
Copyright 2012 Northwest Public Radio


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Macomber School was the headquarters last week for donations of items for hurricane Sandy victims in the New York and New Jersey area. Collections on Monday, Nov.12,and Thursday, Nov. 15, generated an outpouring of support from the community and local firefighters transported items to families on Tuesday. The second collection of the items last Thursday will be brought by Macomber staff (including Principal Julianna Pasetto, who had lived in New Jersey for over 20 years) to hurricane victims in New Jersey. Among those helping out were local businesses such as Estrella Trucking, Perfect Smiles Dentistry, and Coyne and Powers Insurance Agency. Texas Roadhouse and Trio Restaurant provided nourishment for volunteers as they organized and packed over 300 boxes of supplies from over 150 families. Principal Pasetto said she was overwhelmed by the outpouring of support.
Add to favoritesWestport's Macomber School assists Sandy victims
- Published: 1 year ago on November 19, 2012
- By: Bruce Burdett
- Last Modified: November 19, 2012 @ 7:29 am
- Filed Under: News, Schools


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Press release from
Asheville Women in Technology
ASHEVILLE WOMEN IN TECHNOLOGY ANNOUNCES ITS INAUGURAL EVENT, MONDAY FEBRUARY 25 at 8:30AM
Asheville Women in Technology, a newly formed group for women who work and study in various fields of technology in and around Asheville, announces its inaugural event, Monday, February 25, 2013 from 8:30am to 10:00 am. at the TSAChoice, Inc. Training Room at 108 Asheville Commerce Parkway in Candler. The event is free and includes breakfast plus a special presentation, "Women in Technology: Breaking Down the Barriers," by Adrienne Franklin of TSAChoice, Inc.
RSVP to Lynn Banks by emailing email@example.com or by calling 828.225.3397.
Asheville Women in Technology invites women who work or study in the Science, Technology, Engineering, or Math (STEM) fields to join for professional networking, mentorship and learning. This specialized group was formed by women in Asheville who work in a variety of technology fields: Constance Markley of HomeTrust Bank; Dalene Powell of Charter Communications; Heather St. Jacques of Immedion; Monica Warren of Carolina Adventist; and Pam Silvers of A-B Technical Community College.
Special guest speaker Adrienne Franklin is a technology consultant with TSAChoice, Inc. and is one of only 12 women in a company of just over 60 employees. She is excited to help other women develop their potential as well as provide guidance for potential up and coming young ladies in STEM technologies.
Breakfast is sponsored by Charter Communications. There is no fee for this event. Participants are encouraged to bring business cards for a drawing for two admission tickets to the Biltmore Estate.
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Originally posted by: Scott Randall on 3/28/2007 10:05:29 PM
We'll be taking a week's vacation this summer at Lake Tahoe and it's about 6 hours drive north of us. I've been in the area several times skiing, but never fishing. I plan on bringing our 18/5' bassboat up to Tahoe and try my luck at lake trout. Never fished for lake trout and any help would be appreciated. We also would like to try and fish some of the rivers. Any suggestions?