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- Departments
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- Essential Guide To Paddling The Parks
- Essential Park Guide, Winter 2013-14
- 2013 Essential Fall Guide
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- Essential Friends: The Flip Book
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Wrangell-St. Elias National Park and Preserve
Just How Big Is Wrangell-St. Elias National Park? Take A Look
Just how big is Wrangell-St. Elias National Park and Preserve? To give you an idea, check out the accompanying map. It shows how Wrangell-St. Elias would swallow a number of parks you might have considered to be large themselves.
Alaska National Parks Helping Inventory Permafrost To Monitor Climate Change
In Alaska, where about 80 percent of the landscape has been identified as being permafrost, National Park Service scientists are working with several partners to inventory those lands to better monitor climate-change impacts.
Wrangell-St. Elias National Park and Preserve Dedicates Its First Official NPS Campground
Wrangell-St. Elias National Park and Preserve's 13.2 million acres includes some outstanding scenery and wilderness opportunities, but until recently, there have been no formal NPS camping facilities in the park. That's now changed after the dedication of the new Kendesnii Campground.
Where The Wild Things Are: Untamed Americas
Where are the wild things? For those who call a metropolitan area home, and seldom leave its concrete and steel confines, that might be a reasonable question. National Geographic has the answers for you in a two-night series, Untamed Americas, that debuts this Sunday and Monday nights.
Applications Being Accepted for Research Projects In Denali and Other Alaskan Parks
The National Park Service and the Murie Science and Learning Center are seeking applicants for two research fellowships that are available to individuals wishing to conduct research in Denali National Park and Preserve and other arctic and subarctic Alaska national parks.
NPCA Report Paints Somber Portrait Of An Underfunded National Park Service
America is abundantly rich in the "natural assets" found within the National Park System, but inadequate funding by Congress is threatening the core health of that system, according to the National Parks Conservation Association.
Birding In The National Parks: Where Are All The Kittlitz's Murrelets Going?
Data being gathered to help the U.S. Fish and Wildlife Service decide whether the Kittlitz's murrelet should have Endangered Species Act protection shows an alarming direction in the species' population trend.
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KM_Agness_Vessels_Disturb_Kittlitzs.pdf | 287 KB |
Wrangell-St. Elias National Park and Preserve Releases Plan To Repair ORV Trails
A plan to repair off-road vehicle routes in Wrangell-St. Elias National Park and Preserve has been released by the National Park Service, which will need to find an estimated $4 million to have the work performed.
National Park Service Implementing "Flight Following" Technology in Alaska, Perhaps Nation-wide
"Flight following" technology, which can help dispatchers keep an eye on the whereabouts of aircraft, is being required aboard all National Park Service aircraft, or any aircraft carrying Park Service personnel, in Alaska, and soon could be required throughout the National Park System.
Could Joe Miller Really Force the Federal Government to Hand Over Denali National Park to Alaska?
Alaska's latest political upstart, Joe Miller, wants to go Wyoming Gov. David Freudenthal one better. While Governor Freudenthal had threatened to sell state lands within Grand Teton National Park to the highest bidder, Mr. Miller wants the federal government to turn over all national parks to the Alaskan government.
Wrangell-St. Elias National Park and Preserve Releases Draft ORV Plan For Comment
In a bid to gain control over off-road vehicles that environmental groups said were shredding up parts of Wrangell-St. Elias National Park and Preserve, park officials have have released a draft environmental impact statement that looks at ways to better protect the environment from ORVs.
Melting Ice Patch Near Yellowstone National Park Reveals Ancient Hunting Weapon
National parks, long treasured as providing glimpses into our past, are proving to be better time capsules than we might have imagined just a decade ago. Proof lies in a 10,000-year-old hunting weapon found below a melting ice patch near Yellowstone National Park.
National Park Mystery Spot 12 Revealed: It's Kennecott Mines
Going "North to Alaska" brings you to Wrangell-St. Elias National Park & Preserve and to a long-abandoned copper mine community deep inside the park.
Traveler's Top 10 Rivers to Ride in the National Park System
Sure, the most iconic river in all the land is the Colorado that flows through Grand Canyon National Park. But that doesn't mean you can't find quality river trips elsewhere in the National Park System.
Alaska Game Officials Being Asked to Ease Off On Killing Bears and Wolves in National Park Preserves
For many Lower 48ers, the state of Alaska is perceived as a big, raw chunk of wilderness, complete with booming wildlife populations. And perhaps it is, but there's a growing concern that Alaska's wildlife managers are getting carried away with their bag limits on national park landscapes.
Second Round of National Park Service "Centennial Projects" Produces $27 Million Worth of Improvements
Rehabilitation projects, invasive species eradication and biodiversity research were among the $27 million worth of Centennial Initiative projects for the National Park System announced Tuesday by Interior Secretary Dirk Kempthorne and NPS Director Mary Bomar.
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Wrangell-St. Elias National Park and Preserve Working on Off-Road Vehicle Management Plan
From now through January 10 the folks at Wrangell-St. Elias National Park and Preserve will be open to your thoughts on six alternatives aimed at managing recreational off-road vehicle use in the Nabesna Road area.
National Park Quiz 20: The Last Frontier
Alaska Governor Sarah Palin's vice presidential nomination has put Alaska in the national spotlight, so let's orient this week's quiz to the national parks of The Last Frontier. Answers are at the end. If we catch you peeking, we'll make you write "Alaska's state fish is the Oncorhynchus tshawytscha" 100 times on the whiteboard.
National Park Quiz 15: Ring of Fire
This week's quiz tests your knowledge of geologic features and processes in the national parks that lie within the Pacific Ring of Fire, an area of frequent earthquakes and volcanic eruptions that rings the Pacific Basin. Answers are at the end. If we catch you peeking, we'll make you write "convergent boundary" 100 times on the whiteboard.
National Park Quiz 5: Biggest This or That
Bigger is not always better, but it certainly can be interesting. Many national parks claim bragging rights to the biggest something-or-other. Can you sort them out? Take this week's quiz and see how you measure up. Answers are at the end. No peeking.
Twenty-seven Years Ago, Eight National Parks Came to Be
Never before have, and probably never again will, so many national parks come into existence on the same date. Given birth by the Alaska National Interest Lands Conservation Act were Denali, Gates of Arctic, Glacier Bay, Katmai, Kenai Fjords, Kobuk Valley, Lake Clark and Wrangell-St. Elias national parks.
Marketing Alaska's National Parks; Why Not All National Parks?
I hate jumping to conclusions. But that apparently is exactly what I did when I surmised that the proposed $1.5 million centennial project involving the Alaska Travel Industry Association would benefit the cruise-ship industry more than the parks.
Climate Change in Alaska Opens Window to the Past
Warming temperatures are remaking the Alaskan landscape. Sea ice is shrinking, permafrost is melting, glaciers are retreating, polar bears are changing their habits. In Wrangell-St. Elias National Park and Preserve, the warming trend is opening a window into the past, as melting glaciers are revealing artifacts from both the somewhat recent past and prehistoric cultures.
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WRST-Artifacts.pdf | 600.39 KB |
GLBA-Uplift.pdf | 512.01 KB |


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Quick Facts
Best Known For
Tom Jones is a Welsh rock, pop, blues and soul singing legend best known as a hit maker over the last five decades in the U.S. and U.K.
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Tom Jones - Full Biography (45:39)
Tom Jones - Full Biography
One of the most popular vocalists to emerge from the British Invasion, Tom Jones' rags to riches story began in the slums of Wales, took him to London and then all the way to Vegas.
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Answer questions and see how you rank against other players.
Play NowTom Jones. (2014). The Biography Channel website. Retrieved 10:09, Mar 10, 2014, from http://www.biography.com/people/tom-jones-21026065.
Tom Jones. [Internet]. 2014. The Biography Channel website. Available from: http://www.biography.com/people/tom-jones-21026065 [Accessed 10 Mar 2014].
"Tom Jones." 2014. The Biography Channel website. Mar 10 2014, 10:09 http://www.biography.com/people/tom-jones-21026065.
"Tom Jones," The Biography Channel website, 2014, http://www.biography.com/people/tom-jones-21026065 [accessed Mar 10, 2014].
"Tom Jones," The Biography Channel website, http://www.biography.com/people/tom-jones-21026065 (accessed Mar 10, 2014).
Tom Jones [Internet]. The Biography Channel website; 2014 [cited 2014 Mar 10] Available from: http://www.biography.com/people/tom-jones-21026065.
Tom Jones, http://www.biography.com/people/tom-jones-21026065 (last visited Mar 10, 2014).
Tom Jones. The Biography Channel website. 2014. Available at: http://www.biography.com/people/tom-jones-21026065. Accessed Mar 10, 2014.
Tom Jones is a Welsh singer born on June 7, 1940, in Pontypridd, Wales. Influenced as a child by American blues, R&B and rock 'n' roll, over the past five decades the singing legend has produced hits in both the United States. and the United Kingdom. Highlights include classics such as Once Upon a Time; With These Hands; What's New Pussycat?; Green, Green Grass of Home and Delilah. Drawing on his extensive musical experience,
"For the last 40 years I've travelled the world singing and entertaining, bringing a bit of Wales and Great Britain to my friends, colleagues and audiences. I wear my nationality on my sleeve and I'm proud of it!"
Jones became a judge on the BBC reality show The Voice in 2012.
Early Life
Born Thomas John Woodward, Jones entered the world on June 7, 1940, in Pontypridd, Wales. The son of Thomas Woodward and Freda Jones, from an early age Jones loved to sing at gatherings and in the school choir.
He enjoyed listening to music, including BBC radio, which featured American blues, R&B and rock—genres which later influenced his musical style.
As a teen he was more interested in booze and girls rather than his education, so it was no surprise when he quit school at age 16. To earn money he worked as a builder's laborer and a door-to-door vacuum salesman.
Early Career
In 1963, Jones formed the band Tommy Scott and the Senators. The crowds loved them, but growth was limited due to their non-urban location. This changed the next year, when London-based Gordon Mills discovered Jones, bringing him to London and becoming his manager.
With a new solo career, the artist changed his name to Tom Jones. Decca Records signed him, but his first single, Chills and Fever, didn't catch on. However, his second single, It's Not Unusual, peaked at No. 1 on British charts in 1965.
With success came a U.S. appearance, on The Ed Sullivan Show. From 1965 through 1968, Jones had several hit singles, including Once Upon a Time; With These Hands; What's New Pussycat?; Thunderball; Green, Green Grass of Home and Delilah.
'This Is Tom Jones'
From 1969 to 1971, Jones starred in his own TV show, This Is Tom Jones, which aired in both the United States and Great Britain. He spent much of the 1970s touring internationally, releasing albums, hanging out with Elvis Presley and launching a record label, MAM Records, with his manager.
In 1986, Mills passed away, and Jones' son, Mark, replaced him as the singer's manager. The next year Jones released the song A Boy From Nowhere, which put him back on the British charts. From 1988 to 1991, Jones worked on collaboration projects, including Prince's hit song Kiss, which won the MTV Breakthrough Award. Jones also partnered with singer Van Morrison to release the album Carry a Torch.
Later Career
Through the rest of the 1990s, Jones released albums such as The Lead and How to Swing It and Reload, which went platinum six times in the United Kingdom. He also branched into TV and film, appearing as himself on The Simpsons, hosting the MTV Europe Awards and American Music Awards, and acting in the films Mars Attacks and Agnes Brown.
profile name: Tom Jones profile occupation:
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Included In These Groups
James Bond Soundtrack Artists
Bond—James Bond—was introduced to movie fans with the release of the first 007 film, Dr. No, in 1962. The past five decades of James Bond films have included a gamut of soundtrack artists, including Paul McCartney & Wings, who performed the song "Live and Let Die" for the Bond film of the same name; Shirley Bassey, who sang tracks for the films Diamonds Are Forever and Goldfinger; Jack White and Alicia Keys, who performed "Another Way to Die" for Quantum of Solace; Gladys Knight, who sang the title track for License to Kill; Louis Armstrong, who performed "We Have All the Time in the World" (secondary theme) for On Her Majesty's Secret Service; and Adele, who sang the title track for the newest film of the Bond franchise, Skyfall.
James Bond Soundtrack Artists 23 people in this group
Famous Welsh People 16 people in this group
Famous Geminis 556 people in this group

subset: commoncrawl


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"Mr. Deli" brings you the best and biggest corned beef .....Period!
LIVONIA 11320 MIDDLEBELT RD. (S.E. Corner of Plymouth Rd.) LIVONIA, MI 48150 PHONE: 734-422-1100 FAX: 734-422-0501
Find other Bread Basket Deli locations Grand River Redford Royal Oak Eastpointe Clinton Twp.
Ypsi / Ann Arbor Palmer Park Warren Southfield Lincoln Park


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My Sanford Chart allows you secure online access to your personal health information and your child's health information. It's available anywhere you have internet access. There is no cost to you and registering is quick and simple.
Exercise plays a big role in helping Maggie Morris stay in good shape. She got more active along with making healthier food choices.
Her regular routine includes 45 minutes of exercise three or four days a week. She usually uses a recumbent bike or an indoor skier, which mimics the cross-country skiing that she loves. And she hits the cross-country ski trails in the winter and the hiking trails at other times of year.
She increased her exercise slowly. She started on the bike for 10 minutes at a time. Then she worked up to 15 and then 30 minutes.
She also tried something new—yoga.
"I find it's very calming," Morris says. She also likes the stretching involved in yoga.
By | Healthwise Staff |
Primary Medical Reviewer | Kathleen Romito, MD - Family Medicine |
Specialist Medical Reviewer | Rhonda O'Brien, MS, RD, CDE - Certified Diabetes Educator |
Last Revised | January 25, 2013 |
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CreditsPrevious Section:
Exercise helps MaggieLast Revised: January 25, 2013
Author: Healthwise Staff
Medical Review: Kathleen Romito, MD - Family Medicine & Rhonda O'Brien, MS, RD, CDE - Certified Diabetes Educator
This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
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Research shows that #music does all kinds of great things for kids. http://t.co/oq8zjJkkDC #SanfordChildrens 01:50 PM Feb 25 |


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got LIVE if you want it!
Posted: April 3rd, 2011 | Author: Will | Filed under: Live, Music, Will | Comments OffYes indeed. We are still here. And, we'll be appearing live, possibly in a venue near you. To give you a quick round up:
June 25th at The Phoenix (Petaluma) with Aim Low Kid/Stoner Dad, Cropduster, Siren and The Velvet Teen all for an excellent cause.
Get all the details on our show page.
your old pal,


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Study suggests methylation and gene sequence co-evolve in human-chimp evolutionary divergence
Cold Spring Harbor, NY -- Scientists at Cold Spring Harbor Laboratory (CSHL) and the University of Southern California (USC) today published the first quantitative evidence supporting the notion that the genome-wide "bookmarking" of DNA with methyl molecules – a process called methylation – and the underlying DNA sequences corresponding with these marks, have co-evolved in a kind of molecular slow-dance over the 6 million years since humans and chimps diverged from a common ancestor.
The team's findings in some ways defy the conventional understanding of how methylation and related processes work. Broadly known as epigenetic processes, methylation and other means by which the genome is "marked" are usually thought of as altering the way a gene is expressed (i.e., whether it is "on" or "off") without changing the underlying sequence of DNA letters -- As, Gs, Cs and Ts – that "spell out" the gene.
Yet the new research supports theories proposing that methylation changes could drive changes in DNA sequence. The CSHL-USC team specifically suggests that methylation changes, which are reversible, might allow a short-term "flexibility in phenotype" – characteristics that individuals within a species exhibit – that would be a kind of dry run for more permanent genomic changes, if a newly conferred trait proves advantageous.
"This part of our data shows how it is possible for methylation to serve as an agent of evolution," says the co-leader of the research team, Dr. Gregory Hannon, a CSHL Professor and an Investigator of the Howard Hughes Medical Institute. The second team leader is Dr. Andrew Smith, a USC Professor and lab head, who began the project with Hannon while doing postdoctoral research at CSHL several years ago.
The evolutionary insight about methylation is only one of a number of new perspectives that emerge from the team's research paper, which is the cover story in the September 16 issue of the journal Cell. Its publication coincides with advance publication of a sister paper in Molecular Cell by the same team, whose members also include CSHL Professor W. Richard McCombie and co-first authors of the paper, CSHL postdoc Dr. Emily Hodges and doctoral student Antoine Molaro. Hodges is first author of the companion paper, which shows how methylation changes in human blood stem cells are involved in "cell-fate decisions" that help determine how the precursor cells differentiate into mature lineage-specific blood cells.
Cells are reprogrammed in two waves
The project set out to explore one of the most fascinating phenomena in all of biology. Twice in the lives of mammalian cells, DNA is wiped completely clean of epigenetic markings and then reprogrammed. The purpose of this process of erasure and reinscription is still rather mysterious. Only once before has the full set of methyl marks – called the "methylome" – been sequenced in humans with single-nucleotide resolution on a genome-wide basis. The new work sets those results in comparative perspective with the methylomes of another class of cells in humans and chimps, by looking for patterns of similarities and differences.
Each of the two cell types studied represents the "output" of one of the two reprogramming waves. One type was human embryonic stem (ES) cells; this cell type is the progenitor of all so-called "somatic" cells, i.e., cells that "differentiate" into all the tissues and organs of an organism. The methylome of the ES cells used in the current study was generated in a previous study. It is used in the current study for comparative purposes, specifically, to form a comparison with male germs cells sampled from two humans and from two chimpanzees, man's closest evolutionary relative.
"These two cell types, the human ES cell and the human and chimp male germ cell, represent the output of the two re-programming waves, and as such are the basis or 'ground state' for all that will follow, over the life of the individual cell and the organism itself," explains Molaro. "The ES cells subsequently differentiate into lung, blood, heart, liver, brain cells, etc. The germ cells are of course fundamental to sexual reproduction."
Methylation in different cell types vs. within types across species
It has long been known that methylation marks are among the most important factors in determining how a given cell will develop within a given organism and how it will behave once mature. For instance, it is believed that methylation has a great deal to do with how a given stem-like precursor cell "knows" which genes to switch on in order to become a liver cell and not a heart cell, or a brain cell and not a lung cell.
The current study provides the first quantitative evidence of a remarkable fact: the methylation patterns that characterize each class of human or chimp cells – heart, blood, liver, etc. -- are far more different from one another than are the patterns within each cell type when viewed across species. A chimp heart cell will share most of its methylation marks with a human heart cell; but the chimp heart cell's methylation patterns will share comparatively fewer points of commonality when compared with those seen in a chimp's liver cells.
This fact lends quantitative support to the known fact that methylation helps define cell types. But this and other evidence in the research also says something that until now has been purely speculative: by looking very closely at methylation patterns within individuals and across species, one can begin to piece together previously hidden stories about how species grew apart via evolution.
Humans and chimps diverged from their common ancestor about 6 million years ago. That is a very short period on the timescale of evolution, which on our planet began at the point nearly 4 billion years ago when the first self-replicating cells appeared.
The default state for both genomes, chimp and human, is for a given spot capable of methylation to in fact be methylated, according to Hannon. Methylation, when it occurs, involves a chemical process at positions across the genome where a cytosine base is followed by a guanine base – so called CpG sequences. Methyl groups (CH3) attach to the cytosine in such sequences, and do so between 70% and 80% of the time, across both chimp and human genomes.
Comparison of non-methylated regions, across species
The CSHL-USC team derived its most important information based on a close analysis of clusters of CpG sequences in which methylation does not occur. Successive unmethylated CpGs form what are called hypomethylated regions, or HMRs. The team found these to be structurally different in ES cells and sperm cells, within species, and continue to seek an explanation.
HMRs have long been of interest because the DNA sequences of most of the 21,000 human genes are associated with HMRs. Therefore, HMRs – areas without methyl marks – have been used as a rough guide to where genes lie in the vast DNA landscape that is the genome, 98% of which does not consist of genes.
More specifically, most HMRs overlap with the very beginning portions of gene sequences in humans and chimps – places called promoters. This fact is of evolutionary import: places in the genome where genes are regulated tend to be unmethylated. This is the flip side of a fact that has long been known: methylation tends to block gene expression. One way is by blocking access of the cell's transcriptional machinery at promoter sites.
Hannon, Smith and colleagues propose methylation is a potential agent of evolution by applying sophisticated analytic algorithms to small changes in the human vs. chimp methylomes. They cite, in one of several examples, a gene called HTR3E, which encodes a structural unit of a serotonin-receptor protein that is expressed in cells of the nervous system. The gene is found in humans and chimps. But at the site of its promoter, the methylation pattern differs: in humans, the promoter is not methylated and in chimps it is methylated.
The functional significance of this difference cannot be determined on the basis of this information alone. The data is important, however, as one example among many where differences in methylation status between closely related species may provide clues about how adaptive pressure acted differently upon each. A broadening of the work done by the CSHL-USC team to include other species will be needed, says Hannon, in order to shed further and more definitive light on the mutual interactions of genome and epigenome in evolution, over the short and long term.
This work was supported by grants from the National Institutes of Health and by a kind gift from Kathryn W. Davis.
"Sperm Methylation Profiles Reveal Features of Epigenetic Inheritance and Evolution in Primates" appears in Cell on September 15, 2011. The authors are: Antoine Molaro, Emily Hodges, Fang Fang, Qiang Song, W. Richard McCombie, Gregory J. Hannon and Andrew D. Smith. The paper can be accessed online: doi:10.1016/j.cell.2011.08.016
The companion paper, "Directional DNA Methylation Changes and Complex Intermediate States Accompany Lineage Specificity in the Adult Hematopoietic Compartment," appears online ahead of print Sept. 15 in Molecular Cell. The authors are: Emily Hodges, Antoine Molaro, Camila O. Dos Santos, Pramod Thekkat, Qiang Song, Philip Uren, Jin Park, Jason Butler, Shahin Rafii, W. Richard McCombie, Andrew D. Smith and Gregory J. Hannon. The paper can be accessed online at: doi:10.1016/j.molcel.2011.08.026
About CSHL
Founded in 1890, Cold Spring Harbor Laboratory (CSHL) has shaped contemporary biomedical research and education with programs in cancer, neuroscience, plant biology and quantitative biology. CSHL is ranked number one in the world by Thomson Reuters for impact of its research in molecular biology and genetics. The Laboratory has been home to eight Nobel Prize winners. Today, CSHL's multidisciplinary scientific community is more than 400 scientists strong and its Meetings & Courses program hosts more than 8,000 scientists from around the world each year. Tens of thousands more benefit from the research, reviews, and ideas published in journals and books distributed internationally by CSHL Press. The Laboratory's education arm also includes a graduate school and programs for undergraduates as well as middle and high school students and teachers. CSHL is a private, not-for-profit institution on the north shore of Long Island.
Written by: Peter Tarr, Senior Science Writer | email@example.com | 516-367-8455


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Operation Summary for May 30, 2011 - June 1, 2011 |
Monday May 30 The day shift began with Operations monitoring the Tevatron (TEV) store 8781 (274.65E30) and the Recycler stash (154.6E10), with the Antiproton Source (Pbar) stacking (8.2E10), with the Main Injector (MI), Linac, and Booster operating normally, with NuMI off for target replacement, with the MiniBooNE and Meson FTBF T-978 experiments taking beam, and with the Collider Detector at Fermilab (CDF) and D-Zero (D0) using the colliding beams. During the day shift, operators reported that the MI-52 kicker tripped off at 2 PM and would not reset. Operators called in kicker personnel to investigate. The Booster low level RF (LLRF) room temperature got too warm, which caused problems with the Booster RF, and cut off beam to MiniBooNE. FESS personnel investigated the temperature problem and found an air conditioner off; they restarted it. Operators had beam restored to MiniBooNE by the end of shift. During the evening shift, Operations disabled beam to T-978 at 6:14 PM. MI kicker personnel made adjustments to the MI-52 kicker and brought it back online. Operations terminated store 8781 at 10:18 PM, put the TEV into HEP shot setup, and established store 8782 at 11:58 PM with an Average Initial Luminosity (AIL) of 373.16E30. Operators explained that shot setup took a little longer due to some issues with Electron Cooling. Tuesday May 31 The midnight shift began with Operations monitoring store 8782 (332.68E30) and the stash (60.2E10), with Pbar stacking (9.7E10), and with MiniBooNE taking beam. During the midnight shift, Operations established beam to T-978 at 4:30 AM. Operators reported beam position problems with the MI-52 extraction on the Switchyard event; operators tuned to resolve these problems. Operators reported some short downtime due an MI-8 corrector magnet bulk power supply tripping off. During the day shift, Operations established beam to MTA at 2:15 PM. At 2:39 PM, a lightning strike caused the loss of store 8782 due to a fast bypass interlock loop drop out. There was no quench. Operators reported finding a bad power supply at TEV sector D4; EE Support personnel replaced the supply. TEV recovery continued through the end of the shift. A vacuum burst in the MI RF line caused about 20 minutes of downtime. A sequencer ACL script error caused a 22E10 loss of antiprotons during a transfer. Problems with Linac and Booster RF systems caused other short down times. During the evening shift, MTA took beam until 4:37 PM. Operations disabled beam to T-978 at 5:27 PM. Operations had the TEV ready for shot setup by 5:30 PM and established store 8784 at 7:31 PM with an AIL of 397.77E30. Kicker personnel worked on the MI-52 kicker, which caused a few minutes of downtime. Wednesday June 1 The midnight shift began with Operations monitoring store 8784 (168.07E30) and the stash (163.7E10), with Pbar stacking (15.7E10), and with MiniBooNE taking beam. During the midnight shift, Operations established beam to T-978 at 4:17 AM. Operators halted Linac beam at 7:15 AM to prepare Linac and Booster for access. Operations terminated store 8784 at 7:35 AM. Operators prepared CDF, D0, the TEV Transfer Hall, and enclosures A-E for accesses. Operations reported short down times caused by Booster and Linac RF system trips. The Plans for Wednesday The plans for today are to access the TEV for cryo system wet engine repairs and other maintenance work. All TEV work should be completed by late afternoon. The Booster and Linac work should be completed by late morning. The Run Coordinator expects the next shot setup to begin on the evening shift. |
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STYLE: New elegant surroundings with a sophisticated design and pleasing accents.
CUISINE: Old-World Italian classics and modern interpretations.
YOU'LL FIND: Traditional entrées and pastas, emphasis on local and organic foods, and awesome house-made desserts.
Towson is probably better known for its sushi bars and burger joints than for fine dining. Walk up and down the streets and you'll find lots of food groups that make the college crowd happy. But one restaurant stands out amid the storefront eateries—Café Troia.
The family-run operation has managed to turn out lovely Italian specialties for 24 years, catering to a loyal clientele of suburbanites and government workers seeking the niceties of tablecloths and expertly prepared dishes. The dining room may have been small and the bar cramped, but you could always count on a satisfying meal.
It would probably still be in the same location today if lease difficulties with new building owners hadn't arisen, forcing owners Carol Troia and her daughter Lisa Troia Martin to look for new quarters. They didn't have to go far.
In November, they moved directly across the street on Allegheny Avenue into a handsome new space with more tables, great windows, and a much larger bar area. A mellow beige color scheme, reflected in the terrazzo tile, walls, and linens, is soothing and sophisticated. In the evening, subtle lighting creates a romantic glow. There's also an area on the lower level for private functions.
Come summer, a deck off the back dining room promises outdoor relaxation, while glass doors in the front, thrown open to the street, will allow for great people-watching in the style of European trattorias. There's also valet car service, but if you've got quarters, a parking lot is right next-door. (Be vigilant till 9 p.m., though. Baltimore County's dedicated meter patrol does its job all too well.)
Behind the scenes is a state-of-the-art kitchen that allows the restaurant to continue serving favorite menu items while also expanding its offerings. There is now a more concentrated focus on natural and local foods, like eggs from Springfield Farm, free-range poultry, and wild, not farm-raised, fish. Thankfully, the food is still homey, old-fashioned, and, for the most part, well-executed. A perfectly al dente fettuccine with fragrant bolognese sauce (a hearty tomato-veggie-beef ragù) and a melt-in-your-mouth braciola (beef roulade with spinach, pine nuts, and Romano cheese in tomato sauce) with plump potato gnocchi transported us across the ocean to quaint Italian villages at dinnertime.
Not everything was a hit, though. A lunch dish of pan-seared fresh tuna over crisp salad greens with pretty burgundy raddichio featured paltry chunks of tuna that were dry and flavorless. A savory vegetable lentil soup had so much potential but was sadly tepid. And while our server apologized for the chilly bottle of Volpaia Chianti, we still had to wait for the wine to warm a bit to savor its full-bodied charms.
Interestingly, when we asked about wines, the server just rattled off several offerings and lost us during the recitation. Another time, we were given a wine list, so we know there is one.
These qualms aside, the highlights were bright and promising. The calamari Vesuvius took top honors. It's a favorite appetizer, our server assured us. Indeed. Beautiful rounds of fresh-from-the-sea squid (not the usual fried stuff) blended exquisitely with spicy tomato sauce with hot peppers. Use the accompanying grilled bread to sop up every last drop. We were also told you can get the calamari over pasta for a little bit more money. Nice!
The Caesar salad is a decent rendition with crunchy romaine and a pleasant egg-less (for those who worry about health issues) dressing and Parmesan, but it becomes stellar with the addition of Sicilian anchovies preserved in olive oil (well worth the extra $3 charge). A peppery arugula salad played terrifically off the sweet candied walnuts and a tangy goat-cheese dressing. And whatever you do, beg for the sautéed spinach as a starter or side. The bright-green baby spinach leaves are barely wilted in olive oil with slender garlic slices in the mix. It is one of those basic preparations that awes the palate.
The whims of the market dictate the fresh fish of the day. We were favored with a simply prepared but absolutely delicious branzino (European sea bass) fillet delicately napped in a mild, unobtrusive red-bell-pepper-and-onion sauce that didn't overwhelm the fish. But no matter how much food you have placed in your stomach, you're going to want one of the house-made desserts. They are worth many return visits.
The lemon Napoleon with several layers of flaky phyllo stuffed with an addictive, sweet-tart, lemon-curd-and-whipped-cream filling is my new favorite sweet. A cloud-like tiramisu, inexplicably unavailable on one visit, is also worthy of praise. The ethereal flavors of mascarpone, espresso, and Marsala meld in a captivating way. No less pleasing is a deeply rich Belgian chocolate flan.
The wait staff is professional, and many servers have been with the restaurant for years. That's probably why we were disappointed when the pace of our dinner lagged, while our waitress schmoozed with regular customers or hung out in the bar area with other staff. There was no refill of coffee, and we waited an overly long time to get our check. At one point, we just wanted to give up and feign sleep on the table or put on our coats to get some attention. We behaved, though, and just politely waved our hand when we finally caught her eye.
Troia may have become complacent in some areas, but after two decades, it still delivers a welcome dining reprieve to Towson patrons looking for comforting traditional Italian dishes, delectable sauces and pastas, and those amazing desserts. And the charming Troias, who often circulate the dining rooms chatting with diners, couldn't be more agreeable hosts.
Cafe Troia, 31 W. Allegheny Ave., Towson, 410-337-0133. Hours: 11:30 a.m.-10 p.m. Mon.-Fri., 5-10:30 p.m. Sat. Appetizers: $5-12.95; entrées, $14.50-34; desserts, $5.50-9.50.


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Macula Complete
Potent Macula and Full Body Protection
- Designed to increase energy and to address the nutrient deficiencies associated with diseases of the retina and full body.
- Includes optimal amounts of 43 superior biochemically-balanced ingredients clinically proven to address disease prevention and control disease progression.
- Millions of doctor-recommended doses safely used by satisfied consumers
- Manufactured to Good Manufacturing Practice Standards (GMP)
- 60-day full money back guarantee A Wise Decision!
General Overview of Macula Complete
Macula Complete is a high-energy premium broad-spectrum dietary
supplement of vitamins, minerals and antioxidant phytochemicals designed
to support optimal body and retinal function. When you take Macula
Complete you do not need additional multiple vitamin supplements. Macula Complete is Made in the U.S.A in a NSF GMP registered facility.
Macula Complete includes the nutrients used the three major studies on nutrition as it relates to eye health.
- ARED study
- Lutein Antioxidant Supplement Trial (LAST)
- Phototrop Study (with the exception of Omega-3 fatty acids, which we present as a stand alone product, ZoOmega-3, to ensure fatty acid stability.
The nutrients included in these studies inhibited AMD disease progression in the study participants. We also added efficacious amounts of Alpha Lipoic Acid, CoQ10, and Acetyl-L-Carnitine, which have been suggested in peer-reviewed studies to support the mitochondria, as well as to support production of cellular (ATP) energy.
Recommended dosage: Take 6 capsules per day, 3 with each morning and evening meal.
Precautions: Pregnant and lactating women should consult their physician before taking this formulation. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, or treat any disease.
Age Related Macular Degeneration
Scientific Rationale Supporting Macula Complete
We are very appreciative of the ARED study and its effect on the eye care professionals understanding of the relationship between nutrients and macular degeneration. However, it is noted in the body of the ARED study that 57% of the study participants were already taking antioxidant vitamins before enrolling in this study, and an additional 13% who were not taking supplements chose to take a multi-vitamin mineral supplement on top of the ARED formulation. Therefore, almost 70% of those in the trial also concurrently took an additional RDA-focused multiple.
The Biosyntrx
scientists believes it prudent to offer a potent multiple for the A
Macula Complete is presented in capsule form to assure bioavailability for the older consumer.
Given the vast amount of science that now supports daily intake of Omega-3 EPA and DHA, we recommend that our concentrated fish oil ZoOmega3 (300 mg EPA and 200 mg DHA per capsule) be taken with each daily dose of Macula Complete.
Vitamin A at 2,500 IU
in Macula Complete as retinyl palmitate, guarantees adequate retinol for
night vision, cornea health, wound healing, immune protection and
appropriate cellular differentiation. Vitamin A should always be
presented with zinc and taurine, since they all three play an important
role in optimal photoreceptor function. A number of published studies
link excessive amounts of Vitamin A as retinol to hip fracture in older
people. Macula Complete Vitamin A does not exceed the
B vitamins include
potent amounts of the full-spectrum of the B-Complex. They are included
in Macula Complete to prevent DNA damage which can lead to
inappropriate gene transcription, and to control blood levels of
homocysteine that has been suggested in published studies to increase
the risk of dry A
Vitamin E is presented
in Macula Complete as 30 IU of natural D-alpha tocopherol, primarily
from mixed tocopherols, as well as 30 mg of Vitamin E tocotrienols to
maintain biochemical balance of the 8 different parts of vitamin E:
alpha, beta, gamma and delta tocopherols and tocotrienols. The amount of vitamin E listed on a
supplement fact box in the vitamin section only refers to the amount of
alpha-tocopheral, not the amount of the complete spectrum of vitamin E.
Full-Spectrum Minerals are balanced to
provide proper bio-electrical responses at the cellular level. This is a
major issue for proper enzymatic function in the human body, including
the eye. These minerals include Calcium,
Magnesium, Selenium, Boron, Copper, Manganese, Chromium, Vanadium, and
Zinc at 25 mg is included in Macula Complete. It is chleated with monomethionine for optimal absorption. This zinc is balanced with small amounts of copper and manganese to produce intracellular super-oxide dismutase (SOD) and extracellular manganese super-oxide dismutase (MnSOD), which is necessary to neutralize singlet oxygen and super oxide free radicals. Excessive copper intake is linked to angiogenesis.
Carotenoids are a scientifically balanced mixture of beta and alpha carotenoids, 1 mg of lycopene, 16 mg of FloraGlo lutein plus 4 mg of ZeaGold zeaxanthin, which strengthen the macula and has been suggested to lower the risk of developing certain tes of cancers. New science suggests that the central macula has a distinct preference for zeaxanthin. Macula Complete does not included beta carotene. It is considered safe for those who still smoke and those who have ever smoked or been exposed to second-hand smoke.
Phytochemical Antioxidant anthocyandins - grape seed, bilberry and ginkgo biloba provide potent antioxidant protection from free radical damage in the entire body and the eyes.
Bioflavnoids, (hesperidin, quercetin, and rutin) strengthen the vascular system, which plays an important role in transporting proper nutrients to every organ in the body including the eye.
Trans-Resveratrol is included at the 100 mg level to enhance mitochondrial function, improve insulin sensitivity, reduce inflammation and protect against toxic effects of high-fat diets. Trans-resveratrol is suggested in a number of studies to mimic caloric restriction benefits linked to protection of chromosome caps, or telomeres, that deteriorate with age. Longer telomeres are associated with both longer lives and healthier aging.
Green Tea is included at the 100 mg level to reduce the risk of cancer development and progression. Green Tea is rich in catechin polyphenols, particularly epigallocatechin gallate (EGCG). EGCG is suggested to lower LDL cholesterol levels, and inhibit abnormal formation of blood clots.
Taurine is included to retard the progressive visual field reduction in retinitis pigmentosa and as the universal carrier of lipid soluble vitamins. Taurine intake is suggested to play a significant role in maintaining fluid balance in the eye.
Carnosine is included to slow the progression of cellular cross-linking associated with cataract formation.
Mitotrophic compounds, Lipoic Acid, CoQ10 and Acetyl-l-Carnitine to delay brain mitochondrial decay and aging. They are also suggested to slow the progression of macular degeneration and memory loss in a number of studies. These nutrients boost ATP cellular energy.
B Vitamin Studies
Hyperhomocysteinemia and vitamin score: correlations with silent brain ischemic lesions and brain atrophy.Polyak Z, Stern F. Dement Geriatr Cogn Disord. 2003;16(1):39-45. [abstract]
Betaine supplementation lowers plasma homocysteine in healthy men and women.Steenge GR. Verhoef, P, et al. J Nutr. 2003 May;133(5):1291-5. [abstract]
Hyperhomocysteinemia in Japanese patients with convalescent stage ischemic stroke: Effect of combined therapy with folic acid and mecobalamine.Sato Y, Kaji M, et al. J Neurol Sci 2002 Oct 15;202(1-2):65 [abstract]
Vitamins for chronic disease prevention in adults: scientific review.Fairfield KM, Fletcher RH. JAMA. 2002 Jun 19;287(23):3116-26. Review. [abstract]
Hyperhomocysteinemia and retinal vascular occlusive disease.Abu El-Asrar AM, Addel Gader AG, et al. Eur J Ophthalmol. 2002 Nov-Dec;12(6):495-500. [abstract]
Homocysteine as a risk factor for nephropathy and retinopathy in Type 2 diabetes.Looker HC, Fagot-Campagna A Diabetologia. 2003 May 28 [Epub ahead of print] [abstract]
Vitamin C Studies
Ascorbic acid spares alpha-tocopherol and decreases lipid peroxidation in neuronal cells.Lix, Huang J, May JM. Biochem Biophys Res Commun 2003 Jun 6;305(3):656-61. [abstract]
Vitamin D Studies
Vitamin D and bone health in postmenopausal women.Malabanan AO, Holick MF. J Womens Health 2003 Mar;12(2):151-6. [abstract]
Vitamin D receptor alleles, periodontal disease progression, and tooth loss in the VA dental longitudinal study.Inauaki K, Krall EA, et al. J Periodontol. 2003 Feb;74(2):161-7. [abstract]
Risk of mortality with vitamin E supplements: the Cache County study. Hayden KM, Welsh-Bohmer KA, et al. Am J Med. 2007 Feb;120(2): 180-4 [abstract]
The relationship between serum trace element changes and visual function in heavy smokers.Uz E, Sabin S, Hepsen IF, et al. Acta Ophthalmol Scand 2003 Apr;81(2):161-164. [abstract]
Copper control as an antiangiogenic anticancer therapy: lessons from treating Wilson's disease.Brewer GJ. Exp Biol Med (Maywood) 2001 Jul;226(7):665-73 [abstract]
Depletion of Intracellular Zinc and Copper with TPEN Results in Apoptosis of Cultured Human Retinal Pigment Epithelial Cells.Hyae Jung Hyun, Joon Hong sohn, et al. Investigative Ophthalmology and Visual Science. 2001;42:460-465. [abstract]
Carotenoid Studies
Effects of 4 y of oral supplementation with beta-carotene on serum concentrations of retinol, tocopherol, and five carotenoids.Nierenberg DW, Dain BJ, et al. Am J Clin Nutr 1997 Aug;66(2):315-9. [abstract]
Bioavailablility of elderberry anthocyanins.Milbury PE, Cao G, at al Mech Ageing Dev 2002 Apr;123(8):997-1006 [abstract]
Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma.Quaranta L, Bettelli S, et al. Ophthalmology 2003 Feb;110(2):359-62; discussion 362-4. [abstract]
Influences of taurine and micronutrients on nitric oxide synthase expression and cGMP content in rat retina.Mi MT. Ahu JD, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2000 Nov;16(4):343-6. Chinese. [abstract]
The role of diet in cognitive decline.Solfrizzi V, Panza F, et al. J Neural Transm 2003 Jan;110(1):95-110 [abstract]
Taurine as a universal carrier of lipid soluble vitamins: a hypothesis.Petrosian AM, Haroutounian JE. Amino Acids. 2000;19(2):409-21. Review. [abstract]
Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-l-carnitine, n-3 fatty acids, and coenzyme Q10. Feher, J, Kovacs B, et al. Ophthalmologia 2005 May-June:219(3): 154-66. [abstract]
QWhat is the source of lutein in Oculair and Macula Complete?
The lutein we include in Macula Complete and Oculair (FloraGLO) is the best available. It is 20% crystalline liquid suspended in corn oil, which is purified from marigold petal extract using a very special patented process. This type of lutein is far more bioavailable than the 5% dry form used by most multiple manufacturers. Unlike lutein esters, this lutein is chemically identical to lutein found in spinach, kale, collard greens, and other green leafy vegetables in our diet. We take the extra time to run our powder multiple formulation through dryers (this allows us to use the 20% crystalline liquid) before encapsulating to ensure the best absorption rate for our customers.
QJust what is the macula?
The macula is the most sensitive area in the retina. It is located in the center of the back of the eye where images are focused by the lens system of the eye. Macula means spot, and since the macula is yellowish in color it is called the macula lutea. Lutea means yellow in Latin. Lutein, an important carotenoid antioxidant, is important in the treatment of macular degeneration. Lutein is found in high concentrations in both spinach and kale.
QWhy did my eye doctor suggest that I start with one half dose of Macula Complete for the first two weeks and then build up to the full dosage the second two weeks?
Macula Complete is a concentrated super-potent multiple vitamin/minerar/antioxidant, which can produce an immediate detox effect in some people - these are usually the people who are the most nutrient deficient. It is important that you not discontinue taking Macula Complete if you get slight headaches or upset stomachs. Most people easily adjust to the formulation by starting with one or two capsules a day (always with food) and then slowly working up to the six-per-day full dosage.
QWhy does Macula Complete contain such expensive nutrients like acetyl-l-carnitine, CoQ10 and large amounts of lipoic acid? The other mucula formulations do not include these nutrients.
All of these nutrients have specifically been shown to dramatically improve cellular mitochondria function in histopathologic studies. Improved mitochondria function provides beneficial effects in preventing and treating Age Related Macular Degeneration (AMD).
QDoes excessive zinc supplementation increase the risk of prostate cancer?
The July 2003 Journal of The National Cancer Institute reported that men who supplement with 100 mg of daily zinc are at twice the risk of advanced prostate cancer, as are men who supplement with amounts that excessively exceed the Institute of Medicine safe upper limits of zinc for more than 10 years. This data was collected from a 14 year follow-up survey of 46,974 health professionals. Biosyntrx multiples are designed for long-term use and include no more than 40-50 mg of zinc, as monomethinonine, which is properly balanced with the full-spectrum of minerals for optimal safety.
QIs Macula Complete appropriate for smokers or former smokers?
After lengthly study of both the ATBC and CARET beta carotene/lung cancer trials, the Biosyntrx Scientific advisors are confident that Oculair and Macula Complete are safe for smokers and former smokers. Our research and design team carefully studied the beta-carotene trials from the mid 1990s before including a very small amount of beta-carotene in our multiple formulations to address specific issues of singlet oxygen formation and diseases of the eye. Biosyntrx multiples include less than one (1) mg beta-carotene, which is appropriately balanced with a complete host of carotenoids and other phytonutrient antioxidants, including 400 IUs of mixed tochpherol Vitamin E and 500 mg of Vitamin C, which are both vital to healthy lungs for all who smoke or have smoke damaged lungs. For more information on this subject visit the Friday Pearl sectio
QDoes Macula Complete Include Both Lutein and Zeaxanthin?
Absolutely. Macula tissue preference for these two zanthophylls has been proven to our scientific advisors satisfaction. Macula Complete is the only full-spectrum multiple formulations available to the AMD patients that includes 10 mg of the highest concentrate FloraGlo Lutein, appropriately balanced with 4 mg of pure Zeaxanthin, which is the preferred carotenoid of the central macula. Biosyntrx does not make zeaxanthin label claims for the amount of zeaxanthin or meso-zeaxanthin that might be converted from supplemental lutein, as do most other companies.
QWhat does the word "COMPLETE" mean in the name Macula Complete?
The Macula Complete vitamin/mineral/antioxidant formula is designed to meet the needs of the delicate neurovascular structures in the central, most sensitive part of the retins. In addition to the specific vitamins, minerals and antioxidants needed for retinal health, Macula Complete contains effective amounts of the nutrients that are lacking in most other available products. In other words, when you take Macula Complete, you do not need to take any other multiple vitamin product. Remember, what's good for the eyes is good for the whole body.
QGiven the high-smoking rate profile of AMD patients, and the
cellular competition for transport space of the carotenoids, why would
AMD formulations like Bausch&Lomb's PreserVision and the copy cat companies include 25,000 IUs of beta-carotene in their formulations?
We assume these formulation designers, and the companies who copy them, do not monitor AMD patient lifestyle profiles, or recent vitamin A and carotenoid science. It concerns us that the PreserVision AMD consumers don't always understand that to protect their vascular system and their macula, they need to take additional supplemental antioxidants, vitamins, minerals and xanthophylls that are not included in the PreserVision formulation.
QI've been told that supplemental bilberry and Ginko biloba might increase the risk of retinal bleeding for patients with wet macular degeneration. Is this so?
This is a great question and one that is ask by a number of AMD patients. It's important to understand that although both of these nutrients tend to slightly thin the blood, they also dramatically improve ocular microcirculation and protect the vascular endothelium, as well as inhibit collegen destruction and decrease capillary fragility. Retinal bleeds are normally caused by capillary fragility, not thin blood. Biosyntrx multiple formulations also include an antioxidant bioflavinoid complex that includes quercetin, rutin and hesperidin, which further strengthen the capillaries that feed the eye and the brain, as well as the fragile capillaries formed during subretinal neovascularization.
QShould beta-carotene be used as the primary source of supplemental
Vitamin A and does beta-carotene interfere with Lutein absorption?
Not in the opinion of the Biosyntrx team. Pre-formed Vitamin A, or retinol, is absolutely essential for eye health, wound healing, and proper immune function. Beta-carotene, as pro-formed Vitamin A, only attempts to metabolically convert to retinol when and if the vitamin A cellular stores are retinol deficient. The beta-carotene/retinol conversion becomes more and more difficult with the aging process. Recent science suggests that beta-carotene converts to retinol at less that half the rate once published. Excessive amounts of supplemental hydrocarbon antioxidant carotenoids, which include beta-carotene, are also thought to compete for transport space with the carotenoid xanthophylls like lutein and zeaxanthin, which are particularly important to the prevention of degenerative disease of the macula. Two large-scale studies, CARET and ATBC, su
QIs Macula Complete safe for people who take blood thinners like Coumadin?
Yes it is safe. However, we recommend that Coumadin patients have their clotting time checked on on a regular basis. Essential Fatty Acids, fish oil, vitamin E, bilberry, and Ginko biloba are all reported to slightly reduce clotting time - therefore, it may be necessary to slightly lower the amount of prescription Coumadin taken on a daily basis. We do not recommend patients ever reducing the amount of Coumadin they take without physician knowledge.


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CHINA: Pernod Ricard looks to Asia, despite recent China headache
By Olly Wehring | 29 May 2013
Pernod Ricard is targeting a 5% lift in its market share in Asia within the next two-and-a-half years, although short-term headwinds in China have slowed growth in recent months.
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< Return To Hearing
Dr. Mark B. Myers
Visiting Executive Professor, Wharton Business School A PATENT SYSTEM FOR THE 21ST CENTURY Statement of Richard C. Levin, Ph.D. and Mark B. Myers, Ph.D. Co-Chairs before the Committee on the Judiciary April 25, 2005 As a result, patents are being more zealously sought, vigorously asserted, and aggressively enforced than ever before. There are many indications that firms in a variety of industries, as well as universities and public institutions, are attaching greater importance to patents and are willing to pay higher costs to acquire, exercise, and defend them. The workload of the U.S. Patent and Trademark Office has increased several-fold in the last few decades, to the point that it is issuing approximately 100 patents every working hour. Meanwhile, the costs of acquiring patents, promoting or securing licenses to patented technology, and prosecuting and defending against infringement allegations in the increasing number of patent suits are rising rapidly. In spite of these changes and the obvious importance of patents to the economy, there had not been a broad-based study of the patent system's performance since the Depression. Accordingly, the National Research Council (NRC) assembled a committee that includes three corporate R&D managers, a university administrator, three patent holders, and experts in biotechnology, bioengineering, chemicals, telecommunications, microelectronics, and software, as well as economists, legal scholars, and practicing attorneys. This diversity of experience and expertise distinguishes our panel from nearly all previous commissions on the subject, as does our study process. We held conferences and public hearings and we commissioned our own empirical research. The committee's report, A Patent System for the 21st Century, released a year ago, provides a thoroughly researched, timely perspective on how well the system is working. High rates of technological innovation, especially in the 1990s but continuing to this day, suggest that the patent system is working well and does not require fundamental changes. Nevertheless, there is little evidence that the benefits of more and stronger patents extend very far beyond a few manufacturing industries such as pharmaceuticals, chemicals, and medical devices. Nor is it clear that patents induce additional R&D investment in software, the Internet, banking, logistics and other services where patents are rapidly proliferating, although their roles in the service sector have not been studied systematically. One obvious conclusion of our study is the need for a much more detailed understanding of how the patent system affects innovation in various economic sectors and technology domains. But even without additional study the committee was able to identify five issues that should and can be addressed now. Because the claim that quality has deteriorated in a broad and systematic way has not been empirically tested, conclusions must remain tentative. But there are several reasons to suspect that more issued patents are substandard, particularly in technologies newly subject to patenting. One reason to believe that quality has suffered, even before taking examiner qualifications and experience into account, is that in recent years the number of patent examiners has not kept pace with the increase in workload represented by the escalating number and growing complexity of applications. Second, patent approval rates are higher than in some other major nations' patent offices. Third, changes in the treatment of genomic and business method applications, introduced as a result of criticisms of the quality of patents being issued, reduced or at least slowed down the number of patent grants in those fields. And fourth, there does appear to have been some dilution of the application of the nonobviousness standard in biotechnology and some limitations on its proper application to business methods patent applications. Although quality appears to be more problematic in rapidly moving areas of technology newly subject to patenting and perhaps is corrected over time, the cost of waiting for an evolutionary process to run its course may be too high when new technologies attract the level of investment exhibited by the Internet, biotechnology, and now nanotechnology. What are the costs of uncertainty surrounding patent validity in areas of emerging technology? First, uncertainty may induce a considerable volume of costly litigation. Second, in the absence of litigation, the holders of dubious patents may be unjustly enriched, and the entry of competitive products and services that would enhance consumer welfare may be deterred. Third, uncertainty about what is patentable in an emerging technology may discourage investment in innovation and product development until the courts clarify the law, or inventors may choose to incur the cost of product development only to abandon the market years later when their technology is deemed to infringe. In sum, greater certainty about patent validity would benefit innovators, technological followers, and consumers alike. Second, differences among national patent systems continue to result in avoidable costs and delays. In spite of progress in harmonizing the U.S., European, and Japanese patent examination systems, important differences in standards and procedures remain, ensuring search and examination redundancy that imposes high costs on users and hampers market integration. It is estimated to cost as much $750,000 to $1 million to obtain comprehensive worldwide patent protection for an important invention, and that figure is increasing at a rate of 10 percent a year. Important differences include the following: Only the United States gives preference to the "first to invent" rather than the "first to file." Only the United States requires that a patent application disclose the "best mode" of implementing an invention. U.S. law allows a grace period of one year, during which an applicant can disclose or commercialize an invention before filing for a patent, whereas Japan offers a more limited grace period and Europe provides none. Fifth, access to patented technologies is important in research and in the development of cumulative technologies, where one advance builds on one or several previous advances. Faced with anecdotes and conjectures about restrictions on researchers, particularly in biotechnology, we conducted a modest survey of diverse participants in the field to determine whether patent thickets are emerging or access to foundational discoveries is restricted. We found very few cases although some evidence of increased research costs and delays and much evidence that research scientists are largely unaware of whether they are using patented technology. During our study, the Court of Appeals for the Federal Circuit ruled that university researchers are not shielded by the common law research exception against infringement liability. This combination of circumstances - ignorance of intellectual property on the one hand and full legal liability on the other - represents an exposure that universities are not equipped to eliminate by the kinds of due diligence performed by companies and investors. Toward a better patent system 1) Preserve an open-ended, unitary, flexible patent system. The system should remain open to new technologies, and the features that allow somewhat different treatment of different technologies should be preserved without formalizing different standards; for example, in statutes that would be exceedingly difficult to draft appropriately and equally difficult to change if found to be inappropriate. Among the tailoring mechanisms that should be exploited is the USPTO's development of examination guidelines for new or newly patented technologies. In developing such guidelines, the office should seek advice from a wide variety of sources and maintain a public record of the submissions. The results should then be part of the record of any appeal to a court, so that they can inform judicial decisions. This information could be of particular value to the Court of Appeals for the Federal Circuit, which is in most instances the final arbiter of patent law. In order to keep this court well informed about relevant legal and economic scholarship, it should encourage the submission of amicus briefs and arrange for temporary exchanges of members with other courts. Appointments to the Federal Circuit should include people familiar with innovation from a variety of perspectives, including management, finance, and economic history, as well as nonpatent areas of law that bear on innovation. 2) Reinvigorate the nonobviousness standard. The requirement that to qualify for a patent an invention cannot be obvious to a person of ordinary skill in the art should be assiduously observed. In an area such as business methods, where the common general knowledge of practitioners is not fully described in published literature likely to be consulted by patent examiners, another method of determining the state of knowledge needs to be employed. Given that patent applications are examined ex parte between the applicant and the examiner, it would be difficult to bring in other expert opinion at that stage. Nevertheless, the open review procedure I will describe next provides a means of obtaining expert participation if a patent is challenged. Gene sequence patents present a particular problem because of a Federal Circuit ruling making it difficult to apply the obviousness test in this field. This is unwise in its own right and is also inconsistent with patent practice in other countries. 3) Institute an "Open Review" procedure. Congress should pass legislation creating a procedure for third parties to challenge patents after their issuance in a proceeding before administrative patent judges of the USPTO. The grounds for a challenge could be any of the statutory standards--novelty, utility, nonobviousness, disclosure, or enablement--or the case law proscription on patenting abstract ideas and natural phenomena. The time, cost, and other characteristics of this proceeding should make it an attractive alternative to litigation to resolve questions of patent validity. For example, federal district courts could more productively focus their attention on patent infringement issues if they were able to refer validity questions to an Open Review proceeding. The result should be much earlier, less expensive, and less protracted resolution of validity issues than we have with litigation and of a greater variety of validity issues than we have with re-examination even if it were used. 5) Modify or remove the subjective elements of litigation. Among the factors that increase the cost and reduce the predictability of patent infringement litigation are issues unique to U.S. patent jurisprudence that depend on the assessment of a party's state of mind at the time of the alleged infringement or the time of patent application. These include whether someone "willfully" infringed a patent, whether a patent application included the "best mode" for implementing an invention, and whether a patent attorney engaged in "inequitable conduct" by intentionally failing to disclose all prior art when applying for a patent. Investigating these questions requires time-consuming, expensive, and ultimately subjective pretrial discovery. The committee believes that significantly modifying or eliminating these rules would increase the predictability of patent dispute outcomes without substantially affecting the principles that these aspects of the enforcement system were meant to promote. 7) Consider enacting a narrrowly drawn exception from infringement liability for some research activities. Here we do not propose specific legislative language, but we do suggest some principles for Congress to consider in drafting a narrow research exception that would preserve the intent of the patent system and avoid some disruptions to fundamental research. In making these recommendations, our committee was mindful that although the patent law is designed to be uniform across all applications, its practical effects vary across technologies, industries, and classes of inventors. There is a tendency in discourse on the patent system to identify problems and solutions to them from the perspective of one field, sector, or class. Although the committee did not attempt to deal with the specifics of every affected field, the diversity of the membership enabled us to consider each of the proposed changes from the perspective of very different sectors. Similarly, we examined very closely the claims made that one class of inventors--usually individuals and very small businesses--would be disadvantaged by some change in the patent system. Some of the committee's recommendations--universal publication of applications, Open Review, and shifting to a first-inventor-to-file system--have in the past been opposed on those grounds. The committee reviewed very carefully, for example, how small entities currently fare in interference proceedings, examination, and re-examination. We also studied how European opposition proceedings impact small businesses. We concluded they enjoy little protection and in fact are often at a disadvantage in the procedures we propose to change. In short, we believe that our recommendations, on balance, would be as beneficial to small businesses and individual inventors as to the economy as a whole. We appreciate the opportunity afforded by the community to testify on our conclusions and would be happy to answer any questions. |


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A collection of relevant and timely media clips and resources.
Posted on December 27, 2012
The U.N. General Assembly voted overwhelmingly on Monday to restart negotiations on a draft international treaty to regulate the $70 billion global trade in conventional arms, a pact the powerful U.S. National Rifle Association has been lobbying hard against.
Read the article: Reuters
United Nations, Arms Trade Treaty (ATT)


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I can't think of a sweeter way to celebrate the upcoming birth of a baby than by sharing it will less fortunate children all over the world? None of this comes as a surprise from Colombian superstar Shakira, who has selflessly given of her time and influence to fight for the underprivileged for many years.
Her baby boy with boyfriend Gerard Pique could arrive at any time and with both being extremely successful, you can bet their bundle of joy will have everything he needs. So the power couple is kicking off a global baby shower where fans and well wishers can donate to UNICEF, a children's charity that Shakira has been a global ambassador for since 2003.
"To celebrate the arrival of our first child, we hope that, in his name, other less privileged children in the world can have their basic needs covered through gifts and donations," the couple said. "Every expectant parent around the world shares all the same hopes and dreams for their children that we do. Yet many don't share the same opportunities. Together we know we can change that."
"Thank you for sharing this unforgettable moment with us."
Check out this video below to listen to the cutest couple on the planet share their message of love:


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Talk:Evolution (episode)
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For general discussion on this episode, visit the TNG forum at The Trek BBS.
Can someone please remind me why it was that Data was not infected by the nanites? Federation 04:26, 6 March 2008 (UTC)
- Because he didn't come into contact with them until he allowed them into his body. -- TrekFan Talk 02:36, 31 August 2008 (UTC)
Speculation Edit
- The reference to 2287 as the last time a starship experienced unexplained system failures may be an in-joke. It could be a reference to the bizarre system failures experienced by Scotty aboard the Enterprise-A in Star Trek V: The Final Frontier, which was released in the same year this episode was broadcast.
Until it's proven it's speculation. — Morder 13:10, 16 October 2008 (UTC)
- I agree, but I'll note that I think the ST Encyclopedia speculated that the statement was a reference to the USS Excelsior.--31dot 13:13, 16 October 2008 (UTC)
- Hmmm...nothing in my copy about that under either "Evolution" or "USS Excelsior". But it is an older edition. If you do find that ref 31dot, I think that's worth adding.– Cleanse 11:18, 17 October 2008 (UTC)
- I said Encyclopedia, but I meant the Chronology, which says "it might refer to the failure of transwarp drive"(the Excelsior). I'm not sure that's worth putting in.--31dot 11:58, 17 October 2008 (UTC)
- Ah, okay. I was hoping it was something like "In a possible in-joke...", in which case I think it'd be cool to add. As it is, meh.– Cleanse 12:16, 17 October 2008 (UTC)
Added passage Edit
I think the recently added passage(copied below) is too long to qualify as a "memorable quote". It isn't memorable scenes or memorable sections. If the memory can't be recaptured in a couple of lines, it's too long.
"... Well, maybe not. But never even to try. To miss your one chance at bat. Do you know baseball?"
"My dad taught it to me when I was little."
"Once, centuries ago, it was the beloved national pastime of the Americas, Wesley. Abandoned by a society that prized fast food and faster games. Lost to impatience. But I have seen the great players make the great plays."
"Do you recreate them on a Holodeck?"
"No, in here... (his mind) With the knowledge of statistics... runs, hits and errors... times at bat... box scores. Men like us do not need Holodecks, Wesley. I have played seasons in my mind. It was my reward to myself. For patience. Knowing my turn would come. Call your shot. Point to a star. One great blast and the crowd rises. A brand new era in astro-physics, postponed one hundred and ninety-six years on account of rain."
- Paul Stubbs and Wesley--31dot 22:37, 22 November 2008 (UTC)
- Amen, brother. --TribbleFurSuit 23:41, 22 November 2008 (UTC)
- Here, Leandar, how about this:
- I have seen the great players make the great plays [...] in here... [indicates head] With the knowledge of statistics... runs, hits and errors... times at bat... box scores. Men like us do not need Holodecks, Wesley. I have played seasons in my mind. It was my reward to myself. For patience. Knowing my turn would come. Call your shot. Point to a star. One great blast and the crowd rises. A brand new era in astro-physics, postponed one hundred and ninety-six years on account of rain."
- - Paul Stubbs
- We can at least get this down to a "memorable" soliloquy (closer to a quote) instead of a dialogue (more of a scene). --TribbleFurSuit 00:20, 23 November 2008 (UTC)
- Here, Leandar, how about this:
- I can live with that, but I wonder what type of precedent that sets.--31dot 00:53, 23 November 2008 (UTC)
- Don't worry about it, I'm just humoring Leandar until he's not looking, then I'll remove it again (JUST KIDDING) unless someone is going to insist on "it's memorable quotes, not memorable speeches". --TribbleFurSuit 01:05, 23 November 2008 (UTC)
FA Nomination Archived (2nd December, 2008)Edit
TNG: EvolutionEdit
Self nomination: I would like to nominate the episode article "Evolution" for FA status. I have spent a fair amount of time on this article, adding the summary, images and quotes. Trying not to sound big-headed, I believe it is a significant improvement from what it once was. -- TrekFan Talk 23:32, 7 October 2008 (UTC)
- Support - While this is not one of my favorite episodes, the article is very well written. The picture quotes are also done well. Great job! ---- Willie LLAP 16:45, 16 October 2008 (UTC)
- Support. To me, it meets the criteria for an FA. Good work.--31dot 14:50, 2 November 2008 (UTC)
- Support – Cleanse 23:11, 2 November 2008 (UTC)
- Support Excellent illustration, good text. --36ophiuchi 23:07, 20 November 2008 (UTC)
- Support: Very well written, great pics. Lots of info. This is a great article! DaveSubspace Message 16:43, 23 November 2008 (UTC)
- Comment: I've given a support to it, shouldn't it now be an FA? DaveSubspace Message 05:42, 1 December 2008 (UTC)
- Comment: Yeah, but I needed to wait seven days to make sure nobody wants to oppose it, as per MA policy. However, the seven day period has now passed and the nomination has been archived.-- TrekFan Talk 15:56, 2 December 2008 (UTC)
Nanites and the Borg Edit
I'm not a know-it-all fan, I just watch it sometimes, but... These nanites do seem a lot like stone-age Borgs. They think as one and are robots and stuff. Does any place tells the origin sotry of the Borg? Because StarTrek is full of those time travel thingies (mostly uncontrolled single events that throw you back in time against your will, as far as I remember (except crewman Daniels)) that could make them past relatives of the Borg, right? Or am I just talking crazy? Probably... 126.96.36.199 00:20, April 10, 2010 (UTC)


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A "cricket" is an insect, but it also may be a footstool. The cricket (footstool) was usually no more than l2 inches high. It was used as a seat for very young children in school or as a foot rest. Larger stools, 12 to 18 inches high, were used for seating teenage children and adults. A few stools were used like steps to help short people get into bed, and some very tall stools were made for stand-up desks. Taverns often used stools as seats. Chairs were made only for kings and very important people until the early 1700s. Chair-makers made stools in popular chair styles. Upholstered stools were billed as chairs were: one charge for the frame, an added one for the upholstery. Fabrics were expensive before the end of the 1800s, so the frame usually cost less than the fabric. Footstools are still popular as pull-up seating, low tables and foot rests and for small children. They have been made in all styles and all sizes.
Q I have an old 9-inch figurine with "Chas Chaplin" engraved into the front of the base. The mark printed on the bottom is "Mark Hampton Co. Inc., 1328 Broadway, New York City, Copyrighted 1915-1910." What is it worth?
A Charlie Chaplin was the most famous film star in the world by the end of World War I. His legacy and star power carry on to the present day. Early 20th-century figurines like yours are collectible. A Mark Hampton Co. Charlie Chaplin figurine in good condition with the original box recently sold at auction for $275.
Q My coffeepot is marked "D.W. Haber & Son, pat. 3994044, N.Y." I have been unable to find out anything about it. It's heavy and polishes up like silver. I bought it for $1 at a yard sale.
A D.W. Haber & Son was founded in 1902 in New York and is still in business. It began as a silver repair business and then began making heavy silver-plated hollowware for hotels, cruise lines and other commercial uses. Since 2001, manufacturing has been done outside the United States. The company holds several patents, which include improvements to chafing dishes, coffeepots, compotes and urns. The patent on your coffeepot is for a heavy-duty hinge for restaurant and commercial ware. It was filed on Dec. 15, 1975, and issued on Nov. 30, 1976.
Q I have a 27-inch-tall bronze sculpture stamped with the name Bouret. It is of a young woman adjusting the skirt layers of her dress. My wife and I inherited the figure years ago. Do you know the history of this sculpture?
A Eutrope Bouret (1833-1906) was a French sculptor. He made many bronze figures, including sculptures of Joan of Arc, classical maidens and Roman gods. Most of his work dates from the late 19th century. His sculptures are collectible, and one of his statues recently sold for $3,256 at auction. But price depends on size, subject and condition.
Q I have some Jaru ceramic accessories from the 1970s: three vases, a covered ginger jar and a stylized nude figurine. They are all covered with a brown glossy glaze. What value would you attach to these pieces?
A Jaru Art Products was started in 1950 by Jack and Ruth Hirsh in Culver City, Calif. The name is a combination of the first two letters of their first names ("Ja" and "ru"). Jaru sold artwares and figurines by different artists. The company later created its own lines. Most pieces were marked with a simple paper sticker, although some have an impressed mark. Jaru changed hands in 1968 and stayed in business until the 1990s by diversifying and importing products. Collectors prefer pieces made before 1980. Your vases and ginger jar could sell for $20 to $75 each; the figurine is worth about $100.
Q I have a Salvador Dali etching of El Cid. There is a certificate of authenticity glued to the back that states it is an original etching. The certificate is from the Collectors Guild of New York City. I'm curious about the value.
A Salvador Dali was a famous 20th-century Spanish surrealist painter. Besides painting, he also experimented with sculpture, film and photography. In the early 1960s, he was commissioned to make a print series titled "Five Spanish Immortals" and based on historic Spaniards. The five included El Cid. The original etchings were printed in a total edition of 180 on two types of paper, one in black ink and one in sepia ink. Each example of this edition was hand-signed by Dali in pencil on the lower right corner. Many were marketed by the Collectors Guild. In 1968 the Collectors Guild published a new edition of the "Immortals." For this edition, Dali etched his name into the printing plate instead of hand-signing the prints. Thousands were printed. A rare hand-signed edition sold at auction in 2012 for $250. An etched-signature edition recently sold for $40.
Tip: Fishing line is strong and almost invisible and can be used to tie fragile items to a base or wall. This will prevent damage from earthquakes, toddlers and dogs with wagging tails.
By sending a letter with a question, you give full permission for use in any Kovel forum. For return of a photograph, include a stamped envelope. Write to Kovel, Farm Forum, King Features Syndicate, 300 W. 57th St., 15th Floor, New York, NY 10019.


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It's not personal, it's digital
How can the 2008 presidential candidates best speak to a tech-savvy, global generation?
In 1948, embattled incumbent Harry S Truman embarked on a cross-country, whistlestop tour, in a last ditch effort to salvage his stake in the presidential election. The situation was dire.
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Infighting had decimated the Democratic Party's base, shattering it into a collection of small tent movements; Dixiecrat Strom Thurmond threatened from one direction, and Republican Thomas Dewey from the other. Voters, Truman reasoned, would have to be appealed to directly – palm to palm, and face to face. As Garrett Graff writes in The First Campaign: Globalization, the Web, and the Race for the White House, Truman, who eventually covered thousands of miles by train, was the last winning candidate to reach – in person – such a wide swath of the electorate. By '52, television had arrived in American homes, and Dwight D. Eisenhower was using "I Like Ike" cartoon shorts and canned "conversations" to bridge the technological divide.
Strategists began to think in terms of infotainment: long policy speeches and public discourse were out, and the age of the horse race was ushered in.
Graff, an editor at Washingtonian magazine, is fascinated by the revolution that took root after '48, mostly because of its similarity to the 2008 election. Like Eisenhower – and later, Nixon and Kennedy – the Democratic and Republican nominees will battle on a new frontier, one rife with opportunity.
"[Changes] wrought by the Web, the BlackBerry, the camera phone, and the like – changes that give ordinary people access to more information (and more kinds of information) than ever before in history – are being brought into politics," Graff argues. "This new technology is a defining feature in the generation of American citizens just now coming of age, a generation that all the candidates are desperate to reach and persuade and one that has joined the voting population only since the 2000 election."
Yet evidence abounds that the candidates have not yet mastered the subtleties of digital campaigning. Consider the case of George Allen, the would-be Republican candidate, who was filmed making racially disparaging remarks at a stop in Southwest Virginia last year. A clip was posted to YouTube, where it became a hit; Allen's chances at the nomination were ground into dust.


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