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A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MEDI0639 in Advanced Solid Tumors
This study is ongoing, but not recruiting participants.
MedImmune LLC
Information provided by (Responsible Party):
MedImmune LLC
ClinicalTrials.gov Identifier:
First received: April 5, 2012
Last updated: February 4, 2014
Last verified: February 2014
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
This is a first-time-in-human, Phase 1, multicenter, open-label, single-arm, dose-escalation (3+3) study to evaluate the safety, tolerability, antitumor activity, PK and immunogenicity of MEDI0639.
Condition | Intervention | Phase |
Solid Tumors |
Biological: MEDI0639 |
Phase 1 |
Study Type: | Interventional |
Study Design: | Allocation: Non-Randomized Endpoint Classification: Safety Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | A Phase 1, Multicenter, Open-label Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MEDI0639 in Adult Subjects With Advanced Solid Tumors |
Resource links provided by NLM:
Further study details as provided by MedImmune LLC:
Primary Outcome Measures:
- Determination of the MTD [ Time Frame: 12 months ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Anti-Tumor [ Time Frame: 24 months ] [ Designated as safety issue: No ]Assessments of antitumor activity will be based on the objective response rate, disease control rate, duration of response, progression-free survival, and overall survival.
- Immunogenicity [ Time Frame: 24 months ] [ Designated as safety issue: No ]Immunogenicity The immunogenic potential of MEDI0639 will be assessed by summarizing the number and percentage of subjects who develop detectable antidrug antibody (ADA).
Estimated Enrollment: | 33 |
Study Start Date: | April 2012 |
Estimated Study Completion Date: | November 2016 |
Estimated Primary Completion Date: | November 2016 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: MEDI0639
Dose 1, Dose 2, Dose 3, Dose 4, Dose 5, Dose 6
Biological: MEDI0639
MEDI0639 is an immunoglobulin G1 lambda (IgG1λ) monoclonal antibody. MEDI0639 selectively binds to DLL4 and blocks its ability to bind to and activate signaling through the Notch receptors.
Detailed Description:
This is a first-time-in-human, Phase 1, multicenter, open-label, single-arm, dose-escalation (3+3) study to evaluate the safety, tolerability, antitumor activity, PK, and immunogenicity of MEDI0639 in adult subjects with advanced solid tumors refractory to standard therapy or for which no standard therapy exist. Up to 63 subjects will be enrolled at approximately 3 to 5 study centers in North America.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Histologically or cytologically confirmed solid tumors that are refractory to standard therapy or for which no standard therapy exist
- Age ≥ 18 years
- ECOG Performance Status of 0 or 1
- LVEF (measured by Echocardiogram) > 50%
- No gastrointestinal bleeding within 1 year of study entry.
Adequate organ and marrow function:
- Hemoglobin ≥ 10g/dL
- Absolute Neutrophil Count ≥ 1500/mm3
- Platelet Count ≥ 100,000/mm3
- AST & ALT ≤ 2.5 x ULN
- Bilirubin ≤ 1.5 x ULN
- Cr Cl ≥ 50 mL/min (as determined by the Cockcroft-Gault equation or by 24-hour urine collection)
- Prior therapy against VEGF or VEGFRs including, but not limited to bevacizumab, sunitinib, sorafenib, pazopanib, motesanib (AMG706), or cediranib (AZD2171), is permitted so long as the agent does not have any known activity against DLL4 and the last dose received s at least 6 weeks prior to first dose of MEDI0639.
- Life expectancy ≥ 12 weeks
- Females of childbearing potential must be surgically sterile, have a sterile male partner, be premenarchal or at least 2 years postmenopausal, practice abstinence or otherwise must use 2 effective methods of contraception from the time of initiation of investigational product.
- Males, unless surgically sterile, must use 2 effective methods of contraception with a female partner and must agree to continue using such contraception for 90 days after the last dose of MEDI0639
Exclusion Criteria:
- Concurrent enrollment in another investigational clinical study
- Receipt of any investigational anticancer therapy within 4 weeks prior to the first dose of MEDI0639 or in the case of monoclonal antibodies, 6 weeks prior to the first dose of MEDI0639
- Concurrent or previous treatment with inhibitors of DLL4
- Any concurrent chemotherapy, radiotherapy, immunotherapy, biologic or hormonal therapy for cancer treatment
- Known bleeding diathesis, esophageal varices, or angioplasty
- Pulmonary hemorrhage or gross hemoptysis within 12 months
- Known arterial or venous thrombosis or pulmonary embolism within 2 years
- Concurrent use of systemic low molecular weight heparin or low dose warfarin
- Presence of brain metastases
- Cerebrovascular accident or transient ischemic attack within 2 years
- Cardiovascular events, such as myocardial infarction, unstable/severe angina, coronary/peripheral artery bypass graft, unstable cardiac arrhythmia requiring medication, congestive heart failure (NYHA > class II), within 2 years
- Tumors with squamous cell histology
- Major surgical procedure within 90 days
- Pregnancy or lactation
- Known HIV positive or Hepatitis A, B, or C infection
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01577745
United States, Connecticut | |
Research Site | |
New Haven, Connecticut, United States, 06519 | |
United States, Michigan | |
Research Site | |
Ann Arbor, Michigan, United States, 48109 | |
United States, New York | |
Research Site | |
New York, New York, United States, 10016 | |
United States, Texas | |
Research Site | |
Houston, Texas, United States, 77030 | |
United States, Washington | |
Research Site | |
Seattle, Washington, United States, 98104 |
Sponsors and Collaborators
MedImmune LLC
Principal Investigator: | David Smith, MD | University of Michigan |
More Information
No publications provided
Keywords provided by MedImmune LLC:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 10, 2014
No publications provided
Responsible Party: | MedImmune LLC |
ClinicalTrials.gov Identifier: | NCT01577745 History of Changes |
Other Study ID Numbers: | CD-ON-MEDI0639-1078 |
Study First Received: | April 5, 2012 |
Last Updated: | February 4, 2014 |
Health Authority: | United States: Food and Drug Administration |
Keywords provided by MedImmune LLC:
Cancer |
Additional relevant MeSH terms:
Neoplasms |
ClinicalTrials.gov processed this record on March 10, 2014


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Guerman's second film about World War II continues his typically oblique glance at the great events of official history by keeping the war offscreen, as the title implies. Twenty Days Without War takes place during a break from the front during which a soldier journeys to another town. The time is the winter of 1942 and the film's title refers to the duration of a furlough taken by Soviet Army Major Lopatin (Yuri Nikulin, a...
Harvard Film Archive Cinematheque
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Unfettered Blog
Why domain expertise isn't important in cybersecurity—not.
I had a meeting with a vendor who is not a control system vendor but is working on control system security. Last year they participated in a webinar when the question was asked what control system cyber events have occurred.
Are you a black hat or a white hat– ACS' conference timing gives you a choice
date is set for August 4-7 at the Marriott Burr Ridge Conference Center near Chicago. Since 2004, the Control System Cyber Security Workshop has been held in early August. The reason for the date was to avoid IEEE, ISA, PCSF, DCS and SCADA User group meetings which generally are...
More on the CIA announcement and culture issues
As noted in a previous blog, I was assured the CIA announcement on the overseas control system cyber attacks was indeed real. The announcement spawned an immense amount of smoke and/or fire- real or fear mongering - as there were essentially no details provided.
The dichotomy between HMI and field devices
Last week at Distributech in Tampa it was interesting to see the dichotomy between many of the HMI suppliers (SCADA) and field device suppliers (PLCs, RTUs, IEDs, smart transmitters and drives, etc.). SCADA and DCS vendors have recognized the need for securing the Windows or Linux-based HMI.
2008 Applied Control Solutions Control System Cyber Security Conference
I am pleased to announce the 2008 Applied Control Solutions Control System Cyber Security Conference will be held August 4-7, 2008 in Burr Ridge, IL (Chicago area). Argonne National Laboratory, one of the national laboratories working on critical infrastructure protection, will co-host this year's event with a focus on interdependencies.
About that CIA disclosure…
I posted this earlier today on the A-List at www.control.com in response to a question about the veracity of the CIA report at SANS: Joe Weiss (www.controlglobal.com/unfettered) and I believe the CIA report to be credible. Why we believe that is not for this public forum. Sorry to be mysterious.
ISA Selects Wurldtech As Service Provider For New Industrial Cyber Security Tool
From the press release:
What, exactly does the CIA know?
has a very interesting and provocative discussion about the CIA disclosure at SANS last week. This is the second time SANS has made an unverifiable disclosure on control system cyber extortion. SANS needs to provide more detailed information not only to validate its authenticity but to provide enough information for i...
FERC plays Solomon with the NERC CIPs
The NERC critical infrastructure protection (CIP) reliability standards to protect the nation's bulk power system against potential cyber security impacts have drawn passionate partisans-those who believe they are sufficient (NERC and the utilities); and those that believe they are not adequate (Congress, control system experts, cyber security experts, etc).


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Mercedes-Benz opens an app store in Europe
As manufacturers figure out how to integrate mobile phone applications with vehicle infotainment systems, Mercedes-Benz decided to cut the middle man out of the picture by opening its own app shop, and let customers download applications directly to their car.
The Mercedes-Benz App Store opened last week, a company spokesperson confirmed in an e-mail. The new online app store will let customers browse for new applications to add to their vehicle's Comand infotainment system. Google Search, Weather, Facebook are standard apps on this system, and Yahoo should be added later this year. Using their phone's Internet connection, they … Read more


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Class Detail
Automotive Brakes, Suspension, Steering & Alignment - 9
A comprehensive course in automotive and light truck brake, alignment, suspension, and steering systems. Designed to give students the skills and knowledge to diagnose and repair these systems to industry standards. Prerequisite: AUTO B64a or B15 or B14. Recommended: Reading level 5 or 6. Hours: 128 lect, 142 lab. Repeat: 1. CCS: Occupational Education. Not Transferable: Associate Degree only.
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Book Description:This popular paralegal-specific text introduces the skills of reading and analyzing court opinions. It focuses on briefing cases and applying case law in legal memoranda and advocacy letters. This is a major revision with new cases and expanded writing chapters.
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Phoenix Auto Insurance
Phoenix Auto Insurance At Low and Affordable Prices
Phoenix auto insurance can be quite expensive if consumers are not aware of all of the tips and tricks on the market that will be able to help them save some money. There are numerous different tips and tricks that will be able to help drivers attain the best insurance rates and policies possible with the main keys being to compare auto insurance plans offered by different auto insurance companies, and also familiarizing oneself with the policies and regulations of each insurance company.
When looking for insurance plans that are suited for different vehicles, it is generally best to consider looking online for quotes. Quotes for Phoenix auto insurance plans can generally be easily attained by submitting personal information to the different insurance companies. This type of information will include driving history, type of vehicle driven, color of vehicle driven, safety features of vehicle, resident location and more. Upon submitting an application for a quote, online applicants are generally able to receive quotes on different auto insurance plans almost immediately. Quotes will be on different insurance plans that the applicant is eligible for, and will include insurance rates for different types of coverage and policy. Thrifty shoppers will know the importance of comparing the different quotes obtained from different insurance companies in order to find the best deals that are around. It is also useful to obtain information from each insurance company's competitors in order to be able to negotiate on insurance plans.
Not only is it important to consider the different quotes that are obtained, but those looking for affordable Phoenix auto insurance plans should highly consider taking a look at the different policies of each company. This will include the different benefits that they are able to provide to their clients.
For example, some insurance companies are able to provide young drivers with additional savings if they provide academic information. Those who have a grade above a certain average will be able to enjoy the benefits that are associated with their grades. Some insurance companies will take these grades as an indication that the driver is a committed and responsible individual. These types of benefits are most beneficial to students who would otherwise be paying extremely high premiums for their auto insurance plan.
Other types of policies to look for when seeking cheaper auto insurance plans is to consider the type of features that the insurance company uses to calculate the auto insurance rates. Some auto insurance companies are willing to lower premiums and insurance rates on cars that have installed certain security systems. Depending on the price of the system, at times it is much more profitable to install the security system than to pay the extra cost.
Some insurance companies will also target car color and more. It is important to be able to familiarize oneself with the policies and the regulation of each auto insurance company. Those who are unfamiliar will want to find an auto insurance agent from the company who will be able to explain the details of each plan and the specific benefits that the auto insurance company is able to offer to their clients. An auto insurance agent should be able to provide information not only on the type of plans that are offered, but also the type of tips and tricks that will be able to help clients save money.
Experienced drivers will want to look for insurance companies with a credit program. This type of program will credit drivers for save driving on the road, and reward them with lower premiums and cheaper Phoenix auto insurance plans. The type of reward should accumulate as safe driving history accumulates.
When shopping for auto insurance plans, it is important to consider the type of coverage that is offered, and the different policies of the company. Consider the term of each plan and the responsibilities that the driver has. Generally speaking, most drivers will want to look for auto insurance plans that will be able to provide full coverage. This will include coverage on all damages to vehicles involved in the accident. Drivers will also want to look for auto insurance plans that will cover the medical expenses of injuries that have been sustained during the accident. Most injuries that are sustained from auto accidents are generally long-lasting, and medical expenses can accumulate over time. Consider whether the auto insurance plan will cover the medical expenses of the passengers and drivers in the other vehicles involved in the accident. These types of auto insurance plans may be a bit more expensive, but they are definitely worth it in the case of accidents.
Auto insurance plans are extremely important for drivers as they are able to provide a sense of protection in case of any accidents. It is important to shop around, and evaluate the different disadvantages and advantages of each plan in order to make an informed decision. There are numerous different types of insurance plans that are available on the market, and it is important for drivers to consider the type of coverage that they need along with the type of premiums that they are willing to pay. Do not opt for plans with high premiums if the premiums are unaffordable despite te fact that the plan may be cheaper. It is important to consider each situation, and the type of affordability of each plan offered by the insurance company.
Phoenix has numerous auto insurance companies, and drivers of any age and experience will be able to filter through all of the different insurance plans that are offered through the online systtem. Not only is it convenient, but it is also considered to be extremely informative as all information is just one quick away. Those who have any questions and inquiries can also contact a customer service representative from the insurance company online. Those who are uncomfortable with the online messaging system can also consider contacting the company via the phone. The internet has definitely made shopping for the perfect Phoenix auto insurance a piece of cake!


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Donna R. Lenhoff has been General Counsel of the National Partnership for Women and Families since 1991. She first came to the National Partnership - then known as the Women's Legal Defense Fund - as its staff attorney in 1978.
One of the key architects of the Family and Medical Leave Act, Lenhoff has written and spoken extensively on balancing work and family, equal employment opportunity, and women's rights. She directs the National Partnership's pro bono litigation and government-affairs advocacy programs to achieve family-friendly workplaces. Lenhoff received her J.D. from the University of Pennsylvania and her B.A. from the University of Chicago, where she was elected to Phi Beta Kappa.
FCA: As a start, could you define the Family and Medical Leave Act?
Donna R. Lenhoff: The Family and Medical Leave Act (FMLA) is a federal law that protects workers' jobs and health insurance while the workers are temporarily out of work to care for a seriously ill parent, spouse or child. It also provides that job protection and continued health insurance for workers who take time off because of their own medical conditions or to care for a newborn or newly adopted child.
All of those conditions together are considered family and medical leave and they all are protected by this law because Congress saw them as compelling family needs that affect working families today.
The FMLA's job protection lasts for 12 weeks during any given year, so as long as the employee is not out of work for more than 12 weeks total during the year, for any of these conditions, the job is held and the health insurance is continued. A couple of caveats: 1) the employer has to provide health insurance in the first place; nothing in this law requires the employer to provide health insurance if the employer doesn't already do so; and 2) the FMLA only applies to workplaces that have 50 or more employees, and to employees who have worked for a year for the same employer and for 1250 hours in the year. These requirements, unfortunately, cut out a lot of people.
Something else important to know: under the FMLA, the 12 weeks of leave need not be consecutive; instead, leave can be taken intermittently if medically necessary. For example, let's say your spouse is in a car accident and for the first week or two you are in the hospital around the clock and not at work. Then there may be a period of recuperation in some sort of intermediate care facility for rehab, and you don't have to be there every day. So, you could go back to work for a month. When your spouse comes home and needs to be cared for at home -- requiring you to set up medical equipment and a new bed, and work out the schedule of home health aides, for example -- you could take another four weeks at that point. So, you may have taken off a total of five or six weeks and still have another six to seven weeks left to take off during the year. At the beginning of each year, the 12 weeks starts running again.
One more caveat: it does have to be a serious health condition of the parent, spouse or child. It can't be a minor thing. And, if you take time off to care for a parent, it has to be your actual parent, but parent is defined functionally to mean a parent who raised you. So, if you were actually raised by your aunt because your mother died and there was never a legal adoption, your job would be protected under the FMLA to care for your aunt. Or your step-parent. But you wouldn't be covered to care for an in-law -- unless you happen to have grown up with your husband and been raised by his mother or father -- a pretty unusual situation!
What is the definition of serious health condition? Does it cover chronic conditions that may have intermittent periods of crisis?
There's a definition in the statute and then an amplification of the definition in the Department of Labor regulations. That's because the Family and Medical Leave Act is enforced by the Wage and Hour Division of the U.S. Department of Labor, which has a toll-free number that people can call to get more information or if they have experienced an FMLA violation (1-800-959-FMLA). The law and regulations are also on their website. [http://www.dol.gov/dol/esa/public/whd_org.htm]
A serious health condition is defined as an illness, injury, impairment or physical or mental condition that involves either "inpatient care" -- which means an overnight stay in a hospital, hospice, or residential medical care facility -- or continuing treatment by a health care provider. The condition for which there's "continuing treatment" has to involve a period of incapacity as well as actual treatment. This includes treatment by a health care provider even on one occasion if it results in a "regimen of continuing treatment" under the supervision of the health care provider, like prescription medication. The Department of Labor regulations say that the "continuing treatment" could also be any period of incapacity, or treatment for such an incapacity, that is due to a chronic, serious health condition.
A chronic, serious health condition, in turn, is defined as one that requires periodic visits for treatment by a health care provider, or by a nurse or physician's assistant under direct supervision of a health care provider; continues over an extended period of time, including recurring episodes of a single underlying condition; and may cause episodic rather than continuous incapacity. Such chronic conditions would include asthma, diabetes and epilepsy. But nonserious health conditions, for example, a chronic cold, are not covered.
You have made reference in a variety of different ways to why the FMLA is important to caregivers. Are there any other ways you would like to comment?
When the FMLA was first passed, people thought of it as being about new babies -- despite the fact that it covered family medical conditions as well. I think the concept of new babies is so appealing in our society that the media focused on that. So it's a little-known fact that family leave also includes leave to care for a seriously ill parent, spouse or child (18 years old or under; for children who are considered disabled under the ADA, there's no age limit). And caregivers don't often think that they have the right to go to their bosses and say they need time off because of caregiving responsibilities. It just does not occur to people -- because they don't think of it as being similar to parental leave.
But in fact, in many ways it is similar: in both situations, there is a period of time when the employee really cannot be at work; she or he really has to be doing the caregiving. After a while, in the caregiving case, hopefully the serious condition is resolved and the family member-- the child, spouse or parent-- is better. So in both cases there is a period of immediate need when the event occurs, and that's the period protected by the FMLA 12 weeks of leave.
As the population ages, as medical care improves overall, and as managed care becomes even more dominant and people stay in hospitals less and less and are discharged to the care of their family members more and more, the need for family leave for caregivers will only grow.
Do you have any statistics or typical examples of caregivers taking off family leave for care of parents or spouses? What is the primary reason people take time off under the leave act?
Actually, 60 percent of leaves taken under the Family and Medical Leave Act are for the employee's own health -- that is, when employees are unable to work because of their own medical conditions. Another 17% of leaves are taken for the birth of a child or the placement of an adopted child in a family. Another 21% are for what I call "family members' medical leave," including 8% to care for a seriously ill child; 4% to care for a seriously ill spouse; and 9% to care for a seriously ill parent.
These statistics are from a survey that was done in 1994 and 1995, when the FMLA first was in effect. Demographics and people's understanding of the law may have changed since then so I'd be interested to know if those numbers for the three categories of family members' medical leave have increased.
Would you like to give some examples of caregiving needs?
Our website [www.nationalpartnership.org] has many examples of people who have taken time off for these leaves. For example, Velma Parness of California, who worked for a university, was the first person in her department to take off time under the Family and Medical Leave Act in 1993 or 1994. Her husband had earlier been diagnosed with a serious cancer, but had treatment and was doing okay. But then his condition deteriorated and he was told he had only a couple of months to live. So she requested family leave. It was a request that kind of flummoxed the department because they'd never encountered the situation before. But sure enough, they talked to their lawyers and discovered that she had the ability to take time off to care for her husband under the Family and Medical Leave Act, and they gave her the leave. She's very grateful for those two months because it enabled her to have that time with her husband before he finally died.
Another example is Lucy Sanchez, a woman here in the Washington, D.C., area, whose husband has had a series of brain tumors and been hospitalized and recovered several times over the last several years. She has been able to take advantage of the Family and Medical Leave Act to take care of him during those periods.
We also hear from a fair number of parents of kids with disabilities who are in many ways some of the most compelling cases of family members' medical leave. We all shudder at the idea of children alone in hospitals and the Family and Medical Leave Act has helped many parents be with their children in those situations.
Would you speak to some of the other aspects of family leave, for example, its being unpaid leave? What happens to caregivers who cannot afford to take unpaid leave? Or those who may not fall under the guidelines, for example, those who work for small employers?
While the FMLA can be very helpful, it does have the several big limitations that you mention. First, to be covered by the FMLA, you have to work for a company with 50 or more employees -- to be precise, 50 employees have to work within 75 miles of your worksite. So, if there are several branches of your company and they're within 75 miles of one another and among them there are 50 employees, you're covered. But if you are in a 10-employee office in San Francisco and the main office is in New York with 1,000 employees, you're not covered.
In addition, you have to have worked for a year for the company -- it doesn't have to be consecutive, but sometime in your life, you have to have worked for a total of a year for that company before you can be eligible under the FMLA; and you also have to have worked for the company for 1,250 hours within the immediately preceding year. This means that people who work less than about 25 hours a week would not be covered, or people who have worked seasonally -- e.g., you might have worked full time but only for four months and you wouldn't be covered.
People who don't meet the eligibility requirements are essentially in the same position the whole country was in before the Family and Medical Leave Act was enacted -- which is that they don't have any source of job protection from federal law. However, they might have job protection from a couple of other sources. One would be state law -- there are a few states that have lower thresholds for coverage, including Maine, Vermont, Oregon, and the District of Columbia. And some state laws provide leave for longer than 12 weeks; if your state law is more generous than the federal FMLA, then it prevails. But, if you're in a state that doesn't have a FMLA law or has a less generous law, the federal law prevails.
Another source of protection might be under a collective bargaining agreement negotiated by your union; if you have a union, you should check with it.
Another coverage problem is for state employees. Recently, some courts have held the Family and Medical Leave Act doesn't apply to state governments. I think they're clearly wrong, but the issue is likely to be resolved ultimately by the Supreme Court.
Does that hold true for federal employees?
No. There's no question, federal employees are covered.
One other possible source of protection--for example, where someone works for a company with 40 employees -- is if you have negotiated a contract with your employer that provides for leave not necessarily through a union but just an individual contract. In some states personnel handbooks are considered enforceable contracts -- this depends on state law. The bottom line on all that is that the major sources of protection, other than the federal law, would be state law or union rights.
There is also legislation pending both in Congress and in a number of states, including California, to lower the threshold for FMLA coverage, so that you'd be covered if you worked for a company of 25 or more employees within 75 miles. If they support that idea, your readers might want to send a note to their Senators and Representatives in Congress and the California Statehouse.
The other big problem with the FMLA of course, is that it only provides unpaid leave. What happens when people go on leave that's unpaid? Well, first, a lot of people don't go on leave because it's unpaid. They can't afford to; instead, they continue to work, generally at great personal hardship for themselves and their family members. Indeed, often when working people can't take time off to be caregivers their family members end up going into nursing homes sooner, and there is ultimately an impact on all of us because of the increased costs of Medicaid. I'd love to see a study on exactly what those costs are.
You won't be surprised to learn that the single biggest reason why people who need family and medical leave don't take it, is that they can't afford it: 64% of all such leave-needers give that reason. And for those needing but not taking leave to care for a seriously ill child the number is even higher -- 73%; 65% for those caring for a seriously ill spouse; and 61% for those caring for a seriously ill parent.
When people do get their leaves partially or even fully paid, the way they do it is to use accrued annual leave and if their employers let them, combine it with sick leave. Many people take only as much time off as is covered by these two paid leaves.
What else do people do to cover their lost wages? Of course people often combine several strategies: 44% of leave-takers use savings earmarked for this purpose (that's probably for new babies because few people earmark savings for taking time off to care for a seriously ill family member). Another 41% use other savings. 25% have to borrow money. 75% limit extras. 39% put off paying the bills. 40% cut their leave short. 9% go on public assistance. And indeed that last number more than doubles as family income drops: among people whose annual family incomes are less than $20,000, fully 21% go on public assistance during their family or medical leave.
That is actually not a surprising statistic since we receive many e-mails from around the country stating that the caregiver has quit their job and now they find themselves without any kind of income and without health insurance.
And they have to go on public assistance. I would wonder how many people quit their job not knowing that they could get at least 12 weeks so they could postpone quitting. They could go on leave, continue their health insurance, try to make other arrangements and perhaps figure out how to get back to work.
What policy recommendations are under consideration to assist those caregivers who can't afford to take unpaid leave?
I'm so glad you asked! At both the federal and state levels there are a lot of policymakers who are looking at this problem of unpaid leave and at its impact on other social systems like public assistance, Medicaid, and how health care is provided in this country; and trying to figure out ways to solve the problem. And when we've had such a long run of economic growth, it's a good time to start looking at different ways of solving this problem.
For example, some employers are voluntarily providing paid leave, some government employers in particular. The federal government, for example, is planning to allow people to use any accrued paid sick leave that they have, not only for their own illness but when they're out to care for a seriously ill family member, up to 12 weeks a year.
Another promising approach is to use existing state insurance systems as a source of income during family and medical leave. There are two major state insurance systems that could be built upon to provide some income for people who are on family leave for caregiving reasons (as well as for people who are on family leave for other reasons, like newborn babies).
Let me describe each of these two existing systems. The first one is state temporary disability insurance (often called "TDI") which is a kind of insurance that pays a portion of people's salary when people are themselves medically disabled and not able to work. State TDI programs cover periods of short-term disability and can provide a crucial bridge for people who are unable to work because of illness until they're able to go back to work. Five states (California, New York, New Jersey, Rhode Island and Hawaii) as well as Puerto Rico require employers to provide temporary disability insurance now, and their systems all run in the black. They've been around for 50 years and cover 22% of the private workforce.
Those systems could be expanded so that you could collect insurance not only when you are out because you yourself are disabled, but also because you're taking care of a family member who is on medical leave, or disabled in some way. In fact, in California, the Governor recently signed a law that commissions a study on what the costs and benefits would be of expanding disability insurance to include insurance for people who are caring for family members who are seriously ill (as well as parents of newborn or newly adopted children). New York is also looking into expanding its TDI system in this way -- there's an active coalition working on it -- and legislation has been introduced in New Jersey as well.
The second existing system that some states are looking at is using their unemployment insurance systems to provide some pay for periods when people are temporarily out of work because of caregiving responsibilities -- which could include caregiving for family members' medical needs. Right now, Massachusetts, Washington state, Connecticut, New Hampshire, Vermont, Indiana, and Maryland are all considering some form of this approach. (We have a round-up of different state efforts on these fronts up on our website, so people can look and see if anything's going on in their state.) In Indiana, the state Assembly has passed a bill to provide paid parental leave through UI; hearings on similar bills have been held in the past month in Vermont, Washington state, and Connecticut.
Canada provides payment during leave for caring for newborn children and seriously ill children through their unemployment system. So there's a close parallel here to using unemployment for caring for family members with medical needs.
Cost estimates for these options vary widely, depending on how many weeks of unemployment would be provided, what the eligibility requirements would be, and whether it would be for just new babies or extend to caregivers and people's own medical conditions. Estimates range from 11 cents per covered employee per week up to $1.45 per covered employee per week.
In Massachusetts, the whole program -- to care for newborn, newly-adopted children, seriously ill parents, children, and spouses and to recover from your serious medical condition -- is estimated to cost only $1.25 per covered employee per week. This totals about $200 million a year, and interestingly, last year there was so much money in Massachusetts's unemployment trust fund that the Governor had proposed an unemployment tax of just that amount -- $200 million. Essentially Massachusetts is being presented with a choice -- do they give better benefits to employees in this way, or do they give it back to the employers in the form of a tax cut?
The Labor Department has also entered this debate. It has issued a notice of proposed ruling (not a final rule yet) that makes it clear that states can use their unemployment systems to provide unemployment to people who are temporarily not working because they are caring for newborn or newly adopted children. This is a narrow interpretation of federal unemployment laws, but we think it's a good start. In fact, we urged the Labor Department to broaden the regulation to allow people to collect unemployment when they're temporarily not working because they are caring for seriously ill family members too.
So what this means is that the Labor Department's regulation will allow the states to go forward and pursue this, if they chose to, on a state by state basis?
Right. But as it's proposed, the Labor Department's regulation would only allow states to do this for leave for new babies or newly adopted children.
If they hear from enough people?
Perhaps, it could be broadened. They have set it up as an experiment so if states take up the option and pass it and it works well, it could be broadened at some point down the line. It's a good model.
There's some other supportive action going on at the federal level as well. In particular, Senators Dodd and Kennedy have introduced the "Family Income to Respond to Significant Transitions (FIRST) Insurance Act," which would provide funding to states that want to set up family leave income programs. That is broad enough that if states wanted to, they could include caregiving leave.
And the Clinton-Gore Administration's proposed fiscal year 2001 budget contains $20 million for planning grants, to allow states to come up with innovative policies in this area. There is a lot of interesting thinking going on at the federal and state levels around the ultimate goal of making family and medical leave more affordable for more working families.
Interview Date: March, 2000
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Renew a registration
Before You Start
To renew online you will need
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When you're finished, you can download and print a temporary (10 day) certificate of registration.
How do I renew my registration?
You can renew your vehicle, boat, snowmobile or light trailer registration online, by mail, or at a DMV office. Allow 2 weeks for your new registration documents to arrive in the mail.
You can't renew a registration that is suspended, revoked, expired for more than 1 year, or has not been inspected in the past 12 months.
How can I know when my registration will expire?
It's printed on your registration documents (see sample registration documents). We also mail you a renewal notice (MV-3) 45 to 60 days before your registration expires. You can go green! and get paperless reminders.
You won't receive a renewal notice if your registration is suspended or revoked. Sometimes notices get lost in the mail. You don't need the notice to renew. 1
If you are in the Armed Forces and are returning from active military duty, you may have more time to renew. Learn more.
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You can renew most vehicles including boats and snowmobiles. Some vehicle are not eligible. 2 When you're finished, you can download and print a temporary (10 day) certificate of registration. You will need
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You can also renew online through My Registrations and Paperless Reminders, and check your registration information at the same time.
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Yes. You can renew online up to one year past the expiration date.
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Can I renew online if I need to change my address?
Your mailing address on DMV files must be current. You cannot change your address during the transaction. You can first change your address online and then renew.
Note: If you file a request with the US Postal Service (USPS) to forward mail, there is no guarantee that the USPS will forward all DMV documents to your new address.
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Yes, but the new document will display your previous name. You cannot change your name during this transaction. If you recently changed your name, read the instructions to change your name or other information on a registration or title.
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Your registration renewal fee is on your renewal notice, and displayed on your computer screen when you renew online.
If you don't have your renewal notice and want to renew by mail, use the estimate registration fees service to calculate the fee amount.
If you do not know the correct amount of your renewal fee, send a check payable to 'Commissioner of Motor Vehicles' with your registration renewal, but do not write the amount. You can delay your registration renewal if you do not correctly calculate the fee.
- 1. You can renew online, by mail using the Vehicle Registration/Title Application (MV-82), or at an office.
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Definition of cross-compiler in English:
Syllabification: cross-com·pil·ernoun
Computing- A compiler that can convert instructions into machine code or low level code for a computer other than that on which it is run.More example sentences
- To compile on Windows, you may need a cross-compiler.
- Here, we use the cross-compiler to demonstrate a simple program.
- This will download and compile the basic cross-compiler tool chain.
More definitions of cross-compiler
Definition of cross-compiler in:- The British & World English dictionary


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BiographyI have been an attending neuroradiologist at Massachusetts General Hospital (MGH) since 1995 and am currently Director of Emergency Neuroradiology and the Radiology Neurovascular Laboratory, and Associate Professor of Radiology at Harvard Medical School. I am board certified in both Internal Medicine and Radiology, with a Certificate of Added Qualification in Neuroradiology. I served as deputy editor for neuroimaging of the journal Radiology from August 2007 through March 2009, for which I continue to be a special consultant deputy editor, and have been on the editorial board of the American Journal of Neuroradiology (AJNR) since 2000. I am Principal Investigator for the CT Perfusion stroke imaging project of the Partners Healthcare, NIH-funded,"SPOTRIAS" program project grant (Specialized Program of Translation Research in Acute Stroke), and for the NBIB funded "point-of-care" center grant studying the clinical feasibility of Electrical Impedance Spectroscopy (EIS).
View my most recent publications at PubMed
As of February 2011:Six Mass General radiologists were recently inducted as American College of Radiology fellows, demonstrating a history of service and dedication to patients.
Phone: 617-726-8321
Phone 2: 617-724-7125
Fax: 617-724-3338


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Message boards : Technical News : Funny (Oct 15 2009)
FYI, the replica database server caught up and I turned the result views back on, etc. There are complaints that some results may have disappeared from the beta database. Bob and Eric are looking into it. In the last thread, this old post of mine (from 2005) was quoted to point out the comedic irony that little has improved despite my claims:
The SETI@home Classic backend is a tangled mess. There have been many problems over the years, most of which were invisible to the participants. None of these problems were fatal to the project or its science, but have resulted in an obnoxious web of ridiculous dependencies, confusing configurations, and unweildy databases. I am practically drooling dreaming of day when we get to turn all that stuff off and be done with it already. The BOINC backend is sooooo much easier to deal with.
At least you saw the humor. More of that is needed at times. ____________
I can see why this is funny (and I agree that it is), but allow me to point out in case people want to use this as some sort of sign of failure
Nothing is easier than before, because the problem will always improvise following the gadgets which you used. Particularly those related to computers and internet *smile* ____________ N = R x fp x ne x fl x fi x fc x L


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Laboratory tests have confirmed that I had the influenza A subtype H1N1 ''swine flu' virus. In January 2012 health officials identified 573 cases of A (H1N1).
3,642 died in 2009 in North America due to the Swine Flu pandemic. On January 16, 2012 I was diagnosed with the H1N1 virus. Photographers always expect something extraordinary happens around us to capture it with our cameras. For 10 days I was isolated in my room hoping that my wife and two sons David and Daniel 3 and 4 years old won't catch the disease. Also I was hoping not to catch pneumonia, the most common fatal complication of this virus. I survived the H1N1 virus and these photographs are a record of the days of my illness in Mexico City.
Image 1 of 18
Oscar Colorado (b. 1969) is a photographer who was born and lives in Mexico City.
Oscar Colorado is research professor of photography at the School of Communication at the Universidad Panamericana in Mexico City.
Among his photographic interests include the social documentary photographyand contemporary art photography.
Oscar Colorado is director Oscar agency image "FotoUP" and of the Origins Project.
To license this work for editorial, creative, or other uses, click on the OZMO logo above.
This will take you to the Ozmo website where you can review the cost and license for the photographs in this exhibit.
You will need to create an account with both Amazon payments and with the Ozmo website as described on the Ozmo website.
Health/healing, Pandemics, Global Health, Healthcare access, h1n1, virus, swine flu, Mexico
The Sidney Morning Herald. Swine flu death toll revised to nearly 300,000 people
Latin America Herald Tribune. Mexico's 2012 Swine-Flu Death Toll Climbs to 81
23 Jan 2012. The Telegraph. Swine flu death toll hits nine in Mexico as cases almost double
Global post. Swine flu kills nearly 200 in Mexico already in 2012
Website: www.oscarcolorado.net
Blog: www.oscarenfotos.com
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United Kingdom & Ireland > Products & Services > Electronics, Electrical and Telecommunications > 3M Electrical Supplies and Components > Products > Cable Identification > Handheld Label Printers
Perfect for a wide range of industrial labelling jobs onsite, at home and in the office. Designed with the same features as the computer keyboard layout and one-touch formatting keys for quick and easy label creation.
Our top of the range model complete for the first time with PC connectivity and packed with innovative, time saving features. The PL300 is designed for demanding situations for installers who want a professional finish to their installations. Complete kit with everything you need!
3M introduces its new range of handheld label printers, great for professional labelling and allowing printing on a wide range of materials. All our hand held label printers are intuitive and easy to use with advanced characteristics and functions. Our top models of handheld label printer such as the PL300 and the PL200 come as a complete kit in a handy, portable carry case complete with everything you need to get started. We also have a full range of refill cartridges.


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US President Barack Obama makes his way to board Air Force One before departing from Homestead Air Reserve Base in Homestead, Florida on March 9, 2014. Obama and his family were returning to Washington after spending the weekend in South Florida. TOPSHOTS/AFP PHOTO/Mandel NGANMANDEL NGAN/AFP/Getty Images
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Read what other Viator.com travelers think about the San Francisco Ferry: Sausalito or Tiburon. What they loved, what they liked and what they think could be improved, it's all here to help you make the most of your next trip.
Click here for tour details, schedule and pricing
It was another beautiful sunny San Francisco's spring day. The queue to get on-board and off was long but it was well organised. Sausalito was lovely as ever. I had a great time.
Wish I had chosen Tiburon instead of Sausalito, with its pricy shops and restaurants. After disembarking, the only thing to do, if on foot, is stroll the main drag and decide where to eat.


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Wed, Dec 05, 2012
A plot to illegally ship aircraft parts to Iran has led to guilty pleas by the two men charged in the scheme. The two were stopped before any parts were shipped in violation of the embargo.
The guilty pleas were announced by David J. Hale, U.S. Attorney for the Western District of Kentucky, Lisa Monaco, Assistant Attorney General for National Security, and Perrye Turner, Special Agent in Charge, Federal Bureau of Investigation, Louisville Division, in a news release. The two men pled guilty to charges related to unlawful export of aircraft and aircraft parts from the United States to Iran. One of the defendants, Hamid Asefi, age 68, is a citizen and resident of the Republic of Iran. The other, Behzad Karimian, also known as "Tony" Karimian, age 53, is a United States citizen living in Louisville, Kentucky who holds a valid Iranian passport and is employed as a Mesaba Airlines Pilot. The guilty pleas were made Monday in Louisville before Magistrate Judge James D. Moyer. The two-count Indictment was returned by a Federal Grand Jury in Louisville, Kentucky on August 2, 2012, and was unsealed before the hearing.
Hamid Asefi and Behzad Karimian were both charged with conspiracy to violate and violation of the International Emergency Economic Powers Act for exporting, selling, or causing the export or sale of aircraft and aircraft parts without first having obtained the required license from the U.S. Department of Treasury. Asefi made his initial appearance in U.S. District Court in Louisville, Kentucky on June 1, 2012. Karimian was arrested and made his initial appearance in U.S. District Court in Louisville, Kentucky on June 6, 2012.
Asefi is the principal officer of Aster Corp Ltd., an Iranian company with offices in both Iran and the United Kingdom. The Indictment charges that, beginning as early as August 2007 and continuing through April 2011, Asefi used the United Kingdom office of Aster to serve as a transshipment point to facilitate shipment of goods from the United States to Iran; Asefi used Aster to facilitate the shipment of goods from the United States to Iran through third party countries; Asefi sent requests on behalf of Iranian entities to Karimian for purchases of aircraft and aircraft parts located in the United States or owned by United States persons; and Karimian knowingly and willfully made inquiries, placed orders, and attempted to facilitate the purchase of aircraft and aircraft parts located in the United States and owned by United States persons on behalf of defendant Asefi and persons in Iran.
The Indictment also asserts that Asefi and Karimian acted with knowledge and intent to violate the Iran embargo when on September 27, 2007, Asefi and Karimian sent email to establish a "profitable business collaboration" for the purpose of procuring aircraft and aircraft components for end-users in Iran. The Indictment further alleges that on or about October 1, 2009, Asefi sent an email to Karimian which outlined the terms of delivery and payment on future transactions with Iran Air and stated "…remember that, only US Embargo has brought this chance and benefit to us, to get involved in these deals…."
According to Count Two of the Indictment, beginning in September 2009 and continuing through April 2010, defendants Asefi and Karimian violated the embargo against Iran by exporting and causing the export of services related to the sale of a G.E. Aircraft Engine Model CF6-50C2, as well as attempting the procurement of helicopters manufactured by Bell Helicopter, from the United States to Iran, without first having obtained the required authorizations from the U.S. Department of Treasury. All of the aircraft and aircraft parts involved in this case were intended for civilian use.
"The investigation and prosecution of national security cases is the top priority of the Department of Justice and my Office," stated David J. Hale, the U.S. Attorney for the Western District of Kentucky. "We view the circumvention of Iranian export control laws as a very serious matter. The FBI should be commended for its excellent work in disrupting this international scheme and bringing these men to justice."
The International Emergency Economic Powers Act authorizes the President of the United States to impose economic sanctions on a foreign country when the President declares a national emergency with respect to a national security threat. On March 15, 1995, the President issued an Executive Order declaring the actions and policies of the Government of Iran constituted a national emergency. On May 6, 1995, the President issued an Executive Order imposing the Iran Trade Embargo. On June 23, 2011, the U.S. Department of the Treasury imposed sanctions on Iran Air after designating it as a proliferator of weapons of mass destruction for providing material support and services to Iran's Islamic Revolutionary Guard Corps.
At sentencing, defendants Asefi and Karimian face a maximum sentence of 40 years in prison, a fine of $500,000, and a three year period of supervised release on each count. Sentencing is scheduled before Chief District Judge Joseph H. McKinley, Jr. on March 4, 2013, at 2pm, in Louisville.
Airborne 03.10.14: WAI2014 Sets Record, NTSB Rules Against FAA On UAVs, Robinson TBO Extension
Airborne 03.07.14: BendixKing KLR 10, Wearable WingX, ANN Announces AEA14 Aero-TV Schedule
Airborne 03.05.14: GA Slapped With User Fees-Again, Fantasy of Flight, Mooney Upgrades
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The EU Reverses Its Carbon Published: Mon, Mar 10 2014
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Campus Housing: I have a single in Balch and therefore I essentially have the largest single possible on Cornell campus. I absolutely love it and then I have a sink mate if I ever get too lonely.
Campus Housing: If you live in newer dorms it's great. There are many good aspects but getting housing is very difficult.
Campus Housing: The Housing Lottery for sophomore year is a challenge. It's very hard to get what you want. As for housing options in freshman year, make sure you see who you're put with before signing the roommate agreement. I had a very bad experience because the "test" the school offers does not really say anything about the person you'll be living with. Me and my roommate were completely different people with a different list of priorities and we were simply incompatible. It was a horrible time for the both of us. Save yourself the trouble and CHECK who you're going to be with before it's too late.
Campus Housing: West campus sucks. its full of nonsocial kids and expensive
Campus Housing: I only lived in dorms my freshman year, and the living was fine, but dorms just didn't agree with me.
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Written by Mandy Kain and Radhika Arora
A new West Campus housing initiative has built five dorms for returning Cornell students, each with a dining hall, common spaces, and a live-in professor to create a communal feeling, similar to that of North Campus. These dorms are much-desired for those who wish to live on campus past freshman year. Some lesser-known options are the themed program houses, and the cooperative houses, where students share in the responsibility of the taking care of the house. These smaller units often create a more familial living environment. Many students choose to live in a fraternity or sorority house on North or West Campus, some of which are owned by Cornell. The quality of these houses varies, although all usually include laundry, a meal plan, and common areas, as well as, of course, access to social activities.
The biggest complaints about on-campus housing are the price of the dorms and the meal plans that are sometimes required to live in certain dorms, like the West Campus housing system. However, such expenses are common at Cornell, and most students agree that living on-campus, especially freshman year, can be an easy way to meet other Cornellians and remain connected to the campus scene.
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Verizon Wireless warms up to Google's Android
Verizon's CEO says the carrier is planning to use Google's Android platform.
It's been an interesting week for America's second-largest cell phone carrier. First, Verizon Wireless announces it would support unlocked handsets and third-party applications on its CDMA network, and yesterday the company's CEO said the carrier may support Google's new Android platform. "We're planning on using Android," said Verizon CEO Lowell McAdam in an interview with Business Week. "Android is an enabler of what we do."
McAdam didn't say when, or if, Verizon would release handsets that use Android, and a Verizon spokeswoman also declined to elaborate in an e-mail. "We certainly expect some in the development community to embrace the Android platform in the open-access devices and applications they develop," wrote Nancy Stark, the spokeswoman. "We have not yet decided whether we will use Android in any of the devices Verizon Wireless offers." Stark added that the company has yet to decide whether it will join the Google's Open Handset Alliance (OHA), which is developing the Android platform. Though Sprint and T-Mobile are founding members of the OHA, neither carrier has confirmed when they will release Android devices.
Both announcements mark a distinct change in Verizon's practices. The company has a long-standing reputation in the cell phone world for being the most draconian of carriers. Not only did it prohibit the use of unlocked phones on its network, but also it limited Bluetooth use, banned third-party applications, and saddled its handset lineup with an unintuitive and stodgy menu interface.


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The A-2 Flight Jacket was made famous by U.S. Army airmen who wore them as a testament to their bravery, independence and skill. Service tested in 1930, the A-2 was adopted as the regulation Army Air Corps flying jacket on May 9, 1931. Its style continues to be a perfect example of form following function.
The A-2 jacket is available and true to the original design in russet or seal brown horsehide or medium brown goatskin.
True to the original Air Corp Spec:
One piece back, 2 piece sleeves. Talon nickel finish zipper with leather puller tabs, single entry pocket with luxurious curved shape flaps. Epaulets boxed stitched, 1 3/4" tapering down to 1 1/2". Hanger loop boxed stitch through and through. Stand up collar, snapped down collar tips. 8-10 stitches per inch, reinforced pockets corners and wind flap, provide solid construction that backed by life time warrantee.
Its lining of 100% cotton and 100% wool knit cuffs & waistband is also true to the original. Finish touch of A/N inspection stamp and Air Corp stamp on the lining.
If you like to create your personal specifications or modified colors, shape or components please visit the A-2 custom made jacket page.
You may also be interested in the following product(s)
Flying Tigers A2 Jacket
Custom Lining
G-1 Custom Jacket
A-2 Custom Jacket
A2 RAAF Flight Leather Jacket
this A2…. is fantastic. Review by Carlos Pereira
My friend Eva Lourenco just arrived from the States and brought to me the A2 Horsehide seal brown that I bought online. This is a wonderful jacket, the color is exactly the same that I saw in flightjacket.com. I´m very pleased to be the owner of the most beautiful jacket I ever had; and you have responsibly of this, so I thank you very much The company made a great job with the manufacturing and you made a great job as a seller.
I've been 6 years in the Portuguese air force, and at the time I had the Portuguese leather flight jacket (it's like the MA1 but in seal brown leather), that was a great jacket too, but this A2…. is fantastic.
Thank you once more
(Posted on 8/29/13) -
1st Class Jacket Review by Christian
I'm very happy with my russet horsehide A2. Quality leather with a superb finish. The workmanship is 1st class right down to the stitching. Love the collar stand which makes the jacket close neatly higher up the neck and gives a slight roll to the collar - Kind of like a Brooks Bros button down shirt. Worn-in in the rain on the West Coast of Ireland the leather is shaping up nicely. After many years of wearing leather jackets, this A2 is a real stand-out piece! Thanks to Shaul for the sizing tips and the fast delivery. (Posted on 8/21/13)
Horse hide seal brown A2 Review by Theo
The jacket is extremely good quality the fit is perfect I am very happy with the jacket . I will certainly be shopping he again . I found the product and company service first class .I highly recommend this company . I placed the order on13/8/13 it arrived her in austrlia on the 19/813. (Posted on 8/19/13)
newly flightjacket addict Review by Aleksander
Ordered my first A2 jacket thru this site. Very fast delivery even if I live in Norway, I would prefer the jacket to be a little more fit around the waist and maybe the arms. But I guess next time I want a more fit jacket, I just get the custom made alternative. Anyways I look awesome in it so no big of a problem. I'm gonna use it in the beginning and the end of winter, so a bit room for thick clothes under the jacket is perfect. Next order in the future is probably gonna be for a sheepskin jacket to keep away those damn cold norwegian winters (Posted on 8/13/13)
blonde bombshell jacket A-2 Review by Andre miller
The support team for this website is amazing.
They responded to my emails very fast and even on a weekend.
Shipping tracking number was right on!!
Oh and the jacket was out of this world amazing.
Highly recommend this company:)
(Posted on 5/30/13) -
Best jacket so far. Review by Russell
First of all, the company is fantastic. I made the order on a Monday and it was at my house on Wednesday. Shipping is very fast and so are e-mails. Secondly, the jacket itself is amazing! I've owned two A2's before this one and they didn't fit, or feel quite right. They were both too big, and the leather was fairly unsatisfactory. I ordered the A2, in horsehide russet, in my sport coat size. When I pulled it out of the box, the smell filled the room and I could immediately tell the leather was of good quality, because it was extremely stiff. I've worn it few times at the airport and when I ride my motorcycle. It fits me very well, and is now starting to break in. Overall I would definitely recommend buying from this company, as well as spending the extra money for the horsehide russet. A fantastic company with a fantastic product. I will definitely buy from here again. (Posted on 5/20/13)
A2 Horsehide Seal Brown Review by xray63
Very beautiful jacket, size fits perfectly.
I have ordered the jacket 3 march end received it in italy 11 march, very good service.
This Company is by far the best internet Company that I have dealt with.
(Posted on 3/11/13) -
Medium Brown Goatskin Review by CW3PA
This jacket is excellent. Two emails & timely responses were all it took to get the correct size. I looked at other sites, but couldn't see any reason to go with them considering the product offered and the steep prices. The fit and workmanship are superb. There have been many complements, and I've recommend your products to any that are interested purchasing a flight jacket. Your web site is easy to navigate & informative. Shipping was fast & the UPS tracking was right on. (Posted on 2/19/13)
Quality,Value ,U.S.Made Review by T.M.
I purchased the goatskin A-2,and am happy to report that we still make quality in the good ol' U.S.A.! Jacket is top quality build,an accurate overall reproduction of a garment that had MANY different contractors in the day,and a great value compared to the top U,K, manufacturers.They also replaced the cuffs on my horsehide A-2 from a different shop. Class operation,super fast shipping,I'm happy to support this bunch with my purchase! (Posted on 2/16/13)
Horsehide A2 jackets Review by Steve
I recently purchased a horsehide A2 and the jacket was so spectacular that I purchased the seal brown version also. Shaul is very responsive to questions over e-mail. I ordered my first jacket on a Tuesday and I had it my hands the next day being on the east coast.
The jackets are sized per the original military specifications, so your normal sport coat size will fit perfectly. I had both jackets made with a combination cotton in the jacket body with smooth red rayon in the jacket sleeves the make it a bit easier to slide in and out of per my 42R build. The jackets are extremely well made and I couldn't find any part of the jacket where I felt there could be an improvement. Both the russet and the seal brown colors are right on the money and are historically correct.
I am a helicopter pilot who belongs to multiple aviation groups. These jackets are turning heads with great interest among the other pilots.
US Authentic is definitely the place to go for military leather. I plan on additional purchases from them. I promise that the A2 will become part of who you are! The look is timeless! (Posted on 12/31/12)
Customer Reviews
- A true treasure! Review by Keith
In November 2013 I purchase a customized horsehide Seal Brown A-2 jacket from Flight Jacket.com. Customized features included G-1 under arm gussets for increased mobility, as well as inside wallet/ cell phone pockets.
I owned a Cooper A-2 about 14 years ago, but sold it to a surplus store when my Airline issued uniform leather jackets to their pilots.
I always loved the military and historic look of the A-2, as well as it's functionality, and decided it was time to put one back on the rack.
I thoroughly researched about a dozen manufactures because I saw the new jacket as a long term investment. I easily decided that Flight Jacket.com was the best in the business. This was based on ease of navigating their informative website, the overall look of their jackets, as well as customer reviews.
I spoke to Shaul numerous times on the phone when discussing the customizing features, and always found the customer support outstanding. The work was completed lightning fast, and shipping was expeditious.
When the jacket arrived in the mail, I wasn't disappointment. It was absolutely beautiful, and exceeded my expectations in terms of workmanship and quality. Now it's time to think about a G-1! (Posted on 1/7/14) - Praise from the true home of the Mighty Eighth ! Review by Tony A
- I am privileged to live in East Anglia, UK just a short haul from Molesworth AFB - WW2 USAAF Station 107. I have a seal brown A2 jacket in horsehide which I wear as tribute to the guys who served here 1942-45. The quality of this jacket is outstanding and the attention to detail is extreme. I can highly praise the dedication of the team at US Authentics for a great jacket. (Posted on 12/20/13)
- Fantastic Goatskin A2 Review by David
- I wish to thank you for the fantastic Goatskin A2 jacket you made for me. This jacket is by far the nicest I own. The details are precise, and the fit is just fantastic. This jacket is very comfortable, and has an athletic fit which is just what I was expecting. Many people on various flight jacket forums such as The Fedora Lounge has given glowing testimonies about the great product you make. They were right on the money. Again, thank you very much for producing a 1st rate A2 jacket that the average person can afford right here in the good old U.S.A. I can not imagine any way to improve your product. It is just perfect. In closing I would like to say once again, Thank You. (Posted on 11/11/13)


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Additional Information
Manufacturer | Whirlpool |
Configuration and Overview | |
Capacity | 3.4 Cu. Ft. |
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ALICE IN WONDERLAND The recently MOMA-ized Tim Burton takes a swing at Lewis Carroll's children's novel of Victorian fantasia with Johnny Depp as the Mad Hatter, Helena Bonham Carter as the Red Queen, Anne Hathaway as the White Queen, and Mia Wasikowska as the titular adventurer. Opens March 5.
BROOKLYN'S FINEST Training Day/Shooter director Antoine Fuqua tackles Sleeper Cell writer Michael Martin's script about three Brooklyn cops who find their own paths to being at the wrong place at the wrong time. Opens March 5.
DECEMBER HEAT Estonian director Asko Kase's 2008 historical drama follows a young soldier's story during a 1924 Communist coup in Tallinn. Screens March 5 at Towson University's Van Bokkelen Hall Auditorium at 7 p.m.
THE GHOST WRITER Director Roman Polanski's latest checks in on the titular writer for hire (Ewan McGregor) who runs into some unsavory things while working on his latest project, the memoirs of a former British Prime Minister (Pierce Brosnan). Opens March 5.
PRINCESS MONONOKE Set in a folkloric version of feudal Japan, Princess Mononoke sports a boffo opening: Young warrior Ashitaka (dubbed by Billy Crudup) must stop a rampaging demon covered in wriggling, leech-like tendrils before it lays waste to his pastoral village. He succeeds, but not before he inherits its evil curse. Forced to leave his home and embark on a quest to discover the source of his ill fortune, Ashitaka comes to a primeval forest where the forces of modernity, led by iron-mining mogul the Lady Eboshi (Minnie Driver), are locked in conflict with the forces of nature, championed by a wild child named San (Claire Danes). What follows is both superlative and all too typical for anime: cute little forest dwellers and characters who are bloodily beheaded by arrows. Miyazaki's laborious animation dazzles, while the characters and themes are complex and shaded. At the same time, the labyrinthine plot and displaced cultural frame of reference will lose anyone who's not completely enthralled to begin with. (Lee Gardner) Screens March 6 at Towson University's Van Bokkelen Hall Auditorium at 7:30 p.m.
WILD RIVER Elia Kazan's under-seen 1960 movie pairs heartthrob Montgomery Clift and beauty Lee Remick in a drama about a Tennessee Valley Authority man (Clift) in charge of clearing an area set to be damned in 1930s when he falls for the granddaughter (Remick) of a woman who refuses to relocate. As shot by veteran cinematographer Ellsworth Fredericks, it's reportedly a gorgeous, lyrical color look at the New Deal '30s. At the Charles Theatre at noon March 6, at 7 p.m. March 8, and 9 p.m. March 10.
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Daily news and top headlines for broadband communications engineering and design professionals
TWC adds live local TV to 'TV Everywhere' in SoCal
December 16, 2013 12:26 pm | by Associated Press | News | CommentsTime Warner Cable Inc. said Friday that it has made live local TV station signals available on its TWC TV app in Los Angeles and San Diego, taking one further step toward fulfilling the industry's promise of making TV programming available on multiple devices. The signals only work for TV subscribers who are also Time Warner Cable Internet customers and are on their home Wi-Fi network.
White House to keep NSA, cyber oversight together
December 13, 2013 1:37 pm | by The Associated Press | News | CommentsThe Obama administration will continue the National Security Agency's surveillance programs and cyber command operations under the direction of a single military commander, the first move in advance of what published reports described Friday as limited changes proposed by a task force that deliberated for months in secrecy.
Report: D3 broadband CPE shipments to grow to 50 million in 2014
December 13, 2013 12:44 pm | by Mike Robuck | News | CommentsAs cable operators continue to expand their DOCSIS 3.0 networks, DOCSIS 3.0 customer premise equipment (CPE) will gobble up more of the market share for devices shipped worldwide. Next year, DOCSIS 3.0 CPE device shimpments will reach 50 million, accounting for more than 89 percent of cable CPE shipments, according to a recent study by ABI Research.
Dyer to take over as CEO of Cox Enterprises
December 13, 2013 12:41 pm | by Mike Robuck | News | CommentsFormer Cox Communications executive John Dyer will take the helm of Cox Enterprises as its new president and CEO on Jan. 1. Dyer will assume leadership of the company following the retirement of outgoing CEO Jimmy W. Hayes. Dyer is currently Cox Enterprises' chief operating officer.
Bright House Networks lights up TV Explorer portal, app
December 13, 2013 12:37 pm | by Mike Robuck | News | CommentsBright House Networks is helping its customers cut through the clutter of finding video content with the launch of its TV Explorer website. In addition to the website, TV Explorer is also available for free as an app on iPads and Android tablets with operating systems of 4.0 or higher.
Ciena narrows 4Q loss on improved revenue
December 13, 2013 12:33 pm | by Associated Press | News | CommentsCiena, a developer of high-speed networking technology, reported Thursday that it narrowed its fiscal fourth-quarter loss on improved revenue. The quarter's revenue exceeded market expectations, but expenses weighed on its profitability
Born free
December 13, 2013 12:17 pm | by Brian Santo | Blogs | CommentsTwo bills were introduced to fix the video market, one from Rep. Steve Scalise, one from Rep. Anna Eshoo. You have to wonder if Scalise was even trying. Just look at that acronym: NGTMA. What are we supposed to do with that? Pronouncing it is a nightmare: N-n-ngitma? Ingateema? Nagtama?
Two bills to reform video market introduced
December 13, 2013 12:09 pm | by Brian Santo | News | CommentsTwo competing bills were introduced in the House Thursday designed to reform retransmission consent and other FCC rules. The one that has greater support thus far would obligate MSOs to create a tier of channels provided through retransmission consent agreements, and would give the FCC authority to block blackouts when retransmission consent negotiations break down.
House Committee passes Spectrum Incentive and FCC Reform Acts
December 12, 2013 1:23 pm | by Ben Munson, Wireless Week | News | CommentsResolution 3675, authored by Chairman Greg Walden and Subcommittee Ranking Member Anna Eshoo (D-CA), passed with an amendment representing "a bipartisan compromise that presents the commission with a framework to bring additional transparency and predictability to the FCC."
Two more studios using Dolby for UltraViolet encoding
December 12, 2013 1:14 pm | by Brian Santo | News | CommentsDolby Laboratories announced that Twentieth Century Fox Home Entertainment and Anchor Bay Entertainment now encode movies and TV programs in the UltraVioletCommon File Format (CFF) using Dolby Digital Plus. With UltraViolet, consumers can download and stream their favorite movies and television programs anytime and anywhere to their TV screens, personal computers, tablets, and mobile phones.
Liberty Global revives bid for Ziggo
December 12, 2013 12:59 pm | by Brian Santo | News | CommentsLiberty Global has returned to Ziggo with another offer to buy out the rest of the Dutch cable company. Ziggo rejected a bid from Liberty Global in October for being too low. Liberty Global already owns 28.5 percent of Ziggo. It also owns the country second largest cable company, UPC Nederland.
Comcast adds more partners to SEEiT platform
December 12, 2013 12:33 pm | by Mike Robuck | News | CommentsStarting in the first quarter of next year, Comcast announced that more distribution and network partners would take part in its SEEiT platform that uses Twitter to click through tweets to programs. Comcast said the new partners would extend the SEEiT experience to millions more viewers by adding additional video distributors, television networks and an expanded roster of popular shows.
Evans boards Comcast as EVP, global corporate development and strategy
December 12, 2013 12:28 pm | by Mike Robuck | News | CommentsComcast Corporation announced this morning that Alexander D. Evans would join the company this month as executive vice president, global corporate development and strategy. Evans will report to Michael Angelakis, who is vice chairman and chief financial Officer for Comcast.
RCN bumps up VOD offerings with upgrade
December 12, 2013 12:26 pm | by Mike Robuck | News | CommentsThanks to a major upgrade to its on demand platform, RCN now has the capacity to offer five times more VOD programs than it could a year ago. Another benefit of the upgrade included RCN being able to add 40 new networks including Fox, NBC, A&E and Disney Jr.
Shaw, Intel invest in automotive apps company
December 11, 2013 1:37 pm | by Brian Santo | News | CommentsShaw Ventures has joined with Intel Capital in an $8 million investment in a UIEvolution, a company that specializes in connecting markets that have so far been of mostly peripheral interest to service providers. These markets include vehicles, wearable devices, augmented reality, and specific business categories, including retail, restaurant, hospitality and cruise.


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Except for the fact that LeBron plays 3.
Here's another guy who only watches the Lakers.
Printable View
I am VERY worried about Cleveland. Lebron is just amazing.
See Rudy Tomjanovich. Are people really questioning Phil? What should he have done differently? He can't make Pau Gasol more tough. He can't make Sasha capable of stopping a Ray Allen drive, and he can't prevent Bynum and Ariza from getting hurt.
People a coach can only do so much good and so much bad. In every sport it comes down to the players.
Doc Rivers was considered a horrific coach before last year. His team ended up winning the title. Was it because he became some coaching savante? No, its because his players were better and they stepped up. End of story.
Do you think Mike Brown is this genius coach? Nope, the Cavs are good because Lebron has taken his game to another level. I could go on and on.
The Lakers "problems" I put that in quotations because there haven't been many of those have little to do with Phil Jackson.
Alot of that had to do with PJ changing the scheme around for game 2. Gasol attacking Yao really made it difficult for him to A)Stay out of foul trouble, and B)be as effective as he wanted to be on the offensive side of the ball.
The real adjustment was the hard double team on Yao, making him give the ball up, something we should've done in Game 1.
We won game 2 because he didn't start. Given the injury and his style of play, Gasol is faster than Bynum, which is what you need to go against Yao. Bynum doesn't have the weight and the quickness (due to injury) to match up against Yao, so you bring in Gasol. That won't be the case should we advance and face the Nuggest in the Conference Finals.
Game/series over! Yao is out the rest of the series with a broken foot.
Posted via Mobile Device
Yep. Here is the link. Yao out for remainder of postseason - NBA - Yahoo! Sports


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Pop superstar Katy Perry visits the BBC Maida Vale studios for a BBC Radio 1 live lounge special on March 19, 2012 in London, UK. The blue-haired singer signed autographs and posed with fans outside the studio.
These Hot Boys Will Make Your Day – The Berry | |
Chris Evan's Heart-to-Heart Moment – Lainey Gossip | |
We Can Hardly Handle The Hotness – The Berry | |
Neville Longbottom Continues To Make Us Drool – Lainey Gossip | |
Cuteness Overload: 32 GIFs That Will Make You Awwwww – The Berry | |
Jared Leto Proves That He's Still Sexy – Lainey Gossip |


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Blender 3D: Noob to Pro/Simple Vehicle: Wheel
This tutorial relies on objects being created so that they are aligned to the view that you're looking through. Versions 2.48 and above have changed the way this works. Visit Aligned to view issue to understand the settings that need to be changed. |
You should already know how to:
- Make a mesh
- Navigate the viewport
- Extrusion
- Create, edit materials
This section will recap and introduce:
- Forming faces
- Subsurfing
- Merging vertices
- Object naming
For our premise, envision jeep tires. They're not too sleek but rather rugged for all kinds of terrain. We need a tire that can handle any obstacle in its way.
Model the tire[edit]
Hit NUM1 to set front view ( XZ coordinates ), then delete the cube.
Create the outside of the tire[edit]
Add a cylinder (SPACE > Add > Mesh > Cylinder, Shift -A on newer versions)
use 32 vertices, set the radius to 4, depth to 3, and un-click the "Cap Ends" button (For 2.6x choose Cap Fill Type: Nothing).
Create the inside of the tire[edit]
Change to NUM1 view and make sure you are in Edit Mode.
Select all vertices, hit EKEY (for blender 2.5X and on-wards, hit "Alt+EKEY" and choose INDIVIDUAL FACES) and on the menu that appears select "INDIVIDUAL FACES" to extrude the individual faces into the circle.
You may either type in -1.2 and hit enter, or Hold SHIFT CTRL while extruding the faces until the sides come in -1.200 units (in older versions of blender hit NKEY first)
Create the outside faces[edit]
Rotate around the model and you'll notice the outside of the tire doesn't yet exist. Let's remedy this.
Go back to NUM1 view.
Invert selection (SPACE > Select > Inverse)
Newer versions: CTRL-I for inverse selection
Press FKEY to create the missing faces, in the menu that pops up select auto
Newer versions: no auto necessary.
noob note: these steps aren't working on 2.69, filled outer faces one by one in my case. unless theres a better way to do it.
noob note: You can use the F2 addon in Blender 2.69 to create faces quickly. Select an Edge and press F and it will create the face based on the direction of the mouse
noob note: In 2.69, it's better to use solidify after doing control CTRL-F than the above process. In edit mode, select all, then press CTRL-F, select solidify in the menu, and type 1.2 for thickness.
NOOB NOTE I had the same problem in 2.69. I simply reversed the process. I created the cylinder with a radius of 2.8, and extruded the faces POSITIVE 1.2. After subsurf, the tire look almost like the pictures, and has the added advantage of a more realistic inner edge without needing creases. There are no inner faces, but that is realistic, isn't it?
Subsurf the tire[edit]
Now it's time to make the tire look like a rugged tire.
Apply a subsurf modifier of level 1 or 2 to the mesh. The tire will now look like a bead necklace. ( If not, remove doubles by going into edit mode -> select all -> WKEY -> Remove Doubles. )
Crease the edges[edit]
A little creative use of creases will restore our tire.
Check that Limit Selection to Visible is off ( now called occlude background geometry on 2.49b).
Enter Edge Select mode
Bring up the circle selection tool (AKEY to unselect all, then CKEY).
Use the scroll wheel to change the circle selection size to be in the center of the tire, between the inside and outside edges. This will select all of the inside edges, as well as the triangles on the side of the tire, as in the picture below.
Now press SHIFT+EKEY to Crease these edges, you can type 1.000, and press ENTER, or hold CTRL to pull in steps till you see 1.000 in the status bar at the bottom of the view window.
Noob note: DO NOT turn the 'limit-selection' tool on for the above selection, also you MUST be in Edge Select Mode or the triangles will not get selected.
Noob note: Make sure that you are in orthogonal view because in perspective view you are not able to make this selection.
Model the hubcap[edit]
The tire is almost done. Let's add a simple hubcap to it.
Create a cylinder[edit]
Be sure you're in Edit Mode
Hit AKEY, once or twice till the wheel is selected
Hit NUM1 for front view
Press SHIFT+SKEY, from the popup menu, cursor->selection, to put the cursor at the center point of the existing tire
Hit space-> add-> cylinder with 32 vertices, radius of 1.9, depth of .5, and make sure the "Cap Ends" button is turned off,
Hit NUM7 for top view
Hit GKEY, then YKEY, then type 2.2, and hit ENTER
Create the outside of the cap[edit]
Hit AKEY once, so that nothing is selected
Hit NUM7 for top view
Zoom in with the MMB till the hub cap fills the view
be sure you're in Vertex select mode
Make sure Occlude Background Geometry Mode is off
hit BKEY for box select, then holding the LMB drag the box along the top edge of the hubcap.
Hit EKEY on the popup select Only Edges, then hit ESC, to create the edges we will need
Hit SKEY, then SHIFT+YKEY to only move in the XZ axis, then type in .35, and hit ENTER
Hit GKEY, then YKEY to only move the Y axiz, then type in .35, and hit ENTER
Create the Axle Cover[edit]
We'll merge these vertices together to create a flat surface.
Hit EKEY, on the popup select only edges, then hit ESC, to create the edges we will need
Hit ALT+MKEY on the popup pick at center. Blender will reduce the 32 vertices to 1.
Hit NUM3 for side view
hit GKEY, then YKEY, to only move the Y axis, then type in -0.4, and hit ENTER
Final sizing of hub cap to tire[edit]
The final mesh editing is to scale the hub cap to a size that is slightly larger than the hole of the tire.
hit NUM7 for top view
position the mouse over the hubcap, and press the LKEY to select the entire hubcap
Hit SKEY, then SHIFT+YKEY to only move the XZ axis, then type 1.48, and hit ENTER
Hit NUM3 for side view
Hit GKEY, then YKEY, to only move the Y axis, then type -1.11 (use -0.77 if you want your hubs sticking out), and hit ENTER
Renaming the Wheel[edit]
The last thing to do is to rename the wheel so we can find it easier later.
Enter Object mode and select the wheel only.
In the Link and Materials subwindow in Editing (F9) you'll see the Active Object name box. It should read OB:Tube in the grey box. This name was created because we started with a tube mesh. In newer versions, it will be cylinder instead of tube.
Click on the button and rename the object to something like 'wheel'. Save your file where you'll find it later and continue to the next step.
Noob note: although not something you should normally do, if you wish to create separately named objects for the hubcap and the wheel you could initially create them both separately in object mode, or split objects in edit mode with P (seParate) or in object mode, join objects with CTRL+JKEY (can cause side effects).
Change the materials to make it look like a tire. One object can have multiple colors/textures, as you will learn in future tutorials.
If you'd like to race ahead, then refer to the materials section for an explanation on how to do that, or to the Blender manual: Multiple Materials