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Bay Theater at Pier 39,
San Francisco
Senior Citizen
The age for senior citizen rate tickets is 65+
Arrival Time
Ticket and pass holders must arrive 20 minutes prior to show time to guarantee admission...
San Anselmo festivals in san jose events
11th Annual San Francisco International Ocean Film Festival
Monday, Mar 10
SF International Chocolate Salon 2014
Saturday, Mar 15
Festival Pavilion,
San Francisco
Chocolate lovers, get ready for a world of premium chocolate!
The original and premier artisan chocolate show on the West Coast takes place this Spring at the 8 th Annual San Francisco Internationa...
Moonlighting SF in March with Burlesque, Diary Reading, Comedy & Singing!
Thursday, Mar 27
50 Mason Social House,
San Francisco
Hi friends,
Please join us for an outrageous, live variety show celebrating the spirit of San Francisco art and culture...
The SF Party Bus
Sunday, Mar 16
Bar None,
San Francisco
The Great Party Bus is San Francisco's favorite Party Bus company with round trip rides to all the Best Concerts, Sporting Events, Wineries and more in the Bay Area...
Yuri's Night: The World Space Party
Saturday, Apr 12
Public Works,
San Francisco
Heading west from his hometown of NY, Sam Spiegel (aka Squeak E. Clean) began DJ'ing clubs and events around Los Angeles...
Noe Valley Chamber Music Presents: The Lee Trio
Sunday, May 4
St. Mark's Lutheran Church,
San Francisco
Sunday May 4 at 4pm, The Lee Trio is making its Noe Valley Chamber Music debut performing a delightful combination of old and new masterworks by Beethoven, Schnabel and Schumann...
Yuri's Night: feat. N.A.S.a & ancient Astronauts
Saturday, Apr 12
Public Works,
San Francisco
Heading west from his hometown of NY, Sam Spiegel (aka Squeak E. Clean) began DJ'ing clubs and events around Los Angeles...
Cuban Salsa with Fito Reinoso y sus Clasicos de Cuba
Saturday, Mar 29
Rhythmix Cultural Works,
RCW is proud to present The Cuban Maestro, Fito Reinoso y sus Clasicos De Cuba to launch its 2014 Island Arts Concert series...
Loco Bloco's Blocura 2014
Saturday, Apr 19
El Patio Español Restaurant,
San Francisco
Saturday, April 19 2014
Cocktail Hour - Silent Auction - Dinner - Dancing - Program
Live Performance by Loco Bloco & Bayonics
DJ spinning Caribbean, Latin & African dance music
Art house short film series @ jessup cellars tasting gallery
Saturday, Mar 15
Jessup Cellars,
December 14 | january 18 | february 15 | march 15
in partnership with the san jose and walnut creek short film festivals, jessup cellars presents a series of short film and wine pairing screenings...
Los Altos Arts and Wine Festival
Saturday, Jul 12
Main and State Street,
Los Altos
Los Altos lies in the heart of Silicon Valley,approximately 40 miles south of San Francisco and 10 miles north of San Jose...
Cactus & Succulent Society of San Jose Spring Show/Sale
Saturday, Apr 5
Peterson Middle School - Multipurpose Room,
Cactus and Succulent Society of San Jose will be holding their Show and Sale on Sat. Apr. 5 (9am-5pm) and Sun. Apr. 6 (10am-4pm). It will be held at Marian A...
Cactus & Succulent Society of San Jose Spring Show/Sale
Sunday, Apr 6
Peterson Middle School - Multipurpose Room,
Cactus and Succulent Society of San Jose will be holding their Show and Sale on Sat. Apr. 5 (9am-5pm) and Sun. Apr. 6 (10am-4pm). It will be held at Marian A...
The 2014 San Jose 'Juneteenth In The Park' Festival - Vendors Wanted!
Saturday, Jun 14
Guadalupe River Park-Discovery Meadow,
San Jose
~*.Promote Your Business At This GREAT Annual 2-Day San Jose FEST!...
San Jose Italian Family Festa
Saturday, Aug 23
Guadalupe River Park & Gardens,
San Jose
Authentic Italian foods, a great variety of continuous entertainment, arts and crafts, and an extensive historical photo display of the local Italian American community...
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So you think Holliday's slide was dirty? The cleat was on the other foot 24 years ago
If you're a Giants fan who is still griping this morning about Cardinals outfielder Matt Holliday's "dirty" slide into Marco Scutaro in last night's NLCS game, you really need to take a chill pill…or maybe some gingko biloba to help with your memory.
It wasn't that long ago that these same two teams were involved in an eerily-similar play. But the cleat was on the other foot.
In July of 1988, a year after the Cards and Giants battled it out in the NLCS (and St. Louis advanced to the World Series only to lose to the Minnesota Twins), San Francisco's Will Clark (who's now a special assistant to the Giants) slid hard into Cardinals second baseman Jose Oquendo (who is now a coach for the Redbirds) to try to break up a double play. It's obvious from the video below that Clark, like Holliday last night, had one thought in his mind during this play: take the second baseman out.
Watch Giants – Cardinals brawl '88 in Sports | View More Free Videos Online at Veoh.com
Unlike Scutaro, who rolled around in pain after Holliday's slide and took some time to get up and regain his faculties, Oquendo wasted no time in letting Will The Thrill know how he felt about the play.
Oquendo got up and slapped Clark upside the head, which ignited a bench-clearing brawl. Later in the game, Giants catcher Bob Brenly and Cardinals shortstop Ozzie Smith would also get into it. To say there is no love lost in the storied history between these two teams would be an understatement.
I can say that I appreciate that Scutaro went about his business last night and used his bat to exact revenge.
However, had the injury been severe enough to cause Scutaro to leave the game (and therefore not be available to contribute the way he did last night), I'm not so sure how appreciative I might be feeling this morning. After all, Scott Cousins' 2011 season-ending blast into Buster Posey is still very fresh in the minds of us Giants fans.
What's done is done and Giants fans should be happy that the game turned out the way it did last night, with the home team winning 7-1 to tie the series at a game apiece.
But I wouldn't be surprised to see more tangling between these two teams over the course of the remaining NLCS games.
Certainly this play is going to spark a lot of debate over the next few days about the rule (or "unwritten rule") of when or how a runner should slide into second. In fact, the rule was changed years ago to mandate that runners "make a bona fide effort to reach and stay on the base" (versus the old tackle method, as used by Cincinnati's Joe Morgan against Oakland second baseman Dick Green in the 1972 World Series).
What do you think about the play last night? Clean or dirty?
One Response to So you think Holliday's slide was dirty? The cleat was on the other foot 24 years ago
Baseball, you should have played when we used steel cleats, and sprent the hour before the game sharpen them up. Holiday is the best player,… for the other team, twice he did not catch the ball, what a dip. The second baseman has to learn to jump, and throw. Watching and reading all the sports writers of today, I wished I had learned to be one, because you don't have to be good anymore, Sorry about that.

subset: commoncrawl


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EOTech and CAMO DREAMS
We were on the calendar to hunt for 3 days at Lily Pad Ranch in Jackson County. This was going to be an extra special dream hunt because of some very special guests. Former major league baseball player (New York Mets) Tombo Martin and his best friend Bamm Woodham, both now with Buck Commander, were going to join us on the hunt. Our special hunter was Bradford Whited, a 12 year old from Panama City, FL who has Muscular Dystrophy. This was going to be Bradford's first ever deer hunt. That first afternoon when Bradford and his Mom Karen arrived we spent some time at the rifle range letting him get used to shooting the EOTech equipped .243 that we had for him to use. He proved quickly that he was a good shot with it. Friday and Saturday found all 7 of us comfortably overlooking some great looking green fields from inside our specially modified peanut wagon. We refer to it as the Dream Wagon. Mike's Custom Welding helped us with the modifications and roof structure that provide almost 100 square feet of wheelchair accessible, highly mobile, deer hunting comfort. While we saw plenty of deer during our 3 days at Lily Pad, the stars were not in the right alignment or somebody was not holding their mouth right and we did not get to connect on a deer for Bradford. So Sunday when everybody was getting ready to head home, Bamm and Tombo said that they wanted to try again to get Bradford a deer and that we could come hunt with them on their personal properties. We got everyone together for a quick Wednesday afternoon hunt for Bradford. Myself, my son Christopher, Chad Redding (Camo Dreams, Inc. vice-pres.), Tombo, and Bamm were going to be hunting at Bamm's place in Calhoun County just west of the Chipola River. He had a stand in mind that had not been hunted since Christmas, the Cadillac Stand. It just did not have room for all of us to sit together like the Dream Wagon. So Bamm and Chad would be close by in stands while Tombo, Christopher, and I would be with Bradford. The anticipation was high and the text messages flying..when or would we even see anything. Then as they typically do 5 does magically appeared at the end of the food plot. We had a doe tag and our goal was to get Bradford a deer, antlers did not matter. As luck would have it none of the does would give him a broadside shot they just kept feeding directly towards the Cadillac stand. This gave us the opportunity to get him positioned at the window and for me to get ready for a follow up shot if need be. We were all ready and the camera was rolling. Bradford had the red dot of the EOtech on the biggest doe in the group waiting for her to turn. We asked him several times if he was on her and if he was ready. When she turned I told him to make sure the dot was behind her shoulder and to fire when he was ready. We waited and waited and waited. Tombo looked over at him and he was watching the deer on the screen of the video camera!!!! That gave us all a chuckle and actually helped settle the nerves. Bradford got settled on the doe and was about to shoot when I noticed a doe at the back of the group getting nervous and looking into the woods. When she bolted out of the food plot I quickly told Bradford to wait just a second that something else was coming out into the food plot. His rack was the first thing I saw as he stepped into the plot. His main beams were shining in the setting sun. I told Bradford that it was a good buck and he needed to shoot him instead of the doe. It seemed like an eternity before he pulled the trigger and the buck lunged into the woods, obviously hit. The celebration began!! After a quick look where the buck had been standing and very little sign to go on we called in the reinforcements. Bamm's cousin Chris has a great tracking dog named Rock that we hoped would make quick work of the limited sign. By the time they got there to start on the trail it had been a nervous hour. Would we find him? Rock however is a superb tracking dog. He trailed that buck across a field, across a creek, and through numerous thickets. Without him we would not have been able to find Bradford;s first deer more than a half mile from where he shot him. When they finally found him we could hear the whoops and hollers rolling through the cold evening air. Since the whole thing happened so quickly we really did not have any idea about the size of the buck. But when we pulled him into the light for Bradford to see for the first time up close everyone was amazed. I took some quick measurements on the 3.5 year old 9 point buck and came up with 120 2/8 B&C, a fantastic first deer. Bradford's smile was from ear to ear and he was speechless. Back at the barn we took a few pictures and recounted the story several times while watching the video. It was a hunt that will forever be etched in the minds of those involved. Bradford's Cadillac Buck.


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Join ConceptArt.Org.
Its' free and it takes less than 1 minute!
Hey All
Currently, I'm working on a new book project that just launched titled "Closet Monsters". Trying my hands at using Kickstarter as it has proven to be a successful way to launch personal projects of all types.
Attached is some of the artwork that I've created. It's been fun and hope you enjoy viewing. Here is a brief description of the book project:
Closet Monsters is an illustrated storybook about a recent college graduate named Rufus whom ventures into the world and accidentally discovers there are plenty of mysterious monsters that surrounds us on a daily bases. And here you thought that all bus drivers and postal workers were just grumpy. Nope. Monsters in disguise. In fact! Since there are so many monsters, Rufus decides to document them all in a 'tell all' cautionary tales field guide. A practical guide for all curious children and even brave parents whom dare to seek them.
For those whom might be interested, here is some info about the actual Kickstarter campaign:
Hope to gain your interest and support.
Thanks for taking a look,
__________________________________________________ _____________________________________
Been a Loooooooonnnnngggg time since I have last posted here on the forums. Its not because the lack of interest, rather simply not having much to show until projects start to launch.
Seem that Conceptart.org has transformed over the years. It's a whole new scene and so I'll just re-introduce myself. Hi, Jason Felix. Writer, Illustrator, Concept Artist, and IP creator for the Entertainment Industry. Been working professional for 15+ years... yikes. Time flies by WAY too fast!!! If you want to see some of my previous work, visit:
This thread will be updated periodically with various projects, games stuff, film, and even personal projects. I'll kick start this thread off by posting some new'ish environment work that I've done between gigs. ANNnnddd this thread will continue grow from here ON out.
Finally! For those whom are interested, I'm also teaching with TAD.
All right! On with the show,
Last edited by Bomba; December 8th, 2012 at 12:20 AM. Reason: update post
Hey! Good work, reminds me at my own shortfilm project Exo. Maybe it is interesting for you too, you can find it here:
I could have play around with these 3D fraktals for ages, they are so inspiring. Did you use Mandelbulber, too? Or did you find a better app?
Keep up the good work!
Thx thirtysix. I'm constantly exploring and experimenting with different software. Currently I'm diggin' Sculptris and will then be ramping up to mastering Z-brush considering its the Industry Standard,
Very cool stuff i like the larger concepts more than the book but that's just me
Sculptris is big fun, but Zbrush multiplies the fun even more. With the latest version Pixologic brings up Dynamesh, a tool within Zbrush which gives you the same freedom as Sculptris. So what you are waiting for? Forget Sculptris and master ZBrush. So I look forward to see more good work from you,
Nice detail work, I really liked the sci-fi enviros. Only crit would be that the alien thing doesn't feel completely integrated in the desert image (shouldn't it be casting a shadow on the ground?).
Icedearth15876- They are completely different styles, makes sense. Thanks for viewing!
Updated image with some alterations. Thx Januz,
Louve the texas destructive architecture
Thanks Andre! Me too. More work on its way...


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Until recently, the landscape for big office-tower deals was an arid one, and between late 2008 and late 2012, only one full sale of a building in the U.S.—Google's headquarters at 111 Eighth Avenue in Manhattan—topped $1 billion, according to Real Capital Analytics.
But now big office-building sales, it seems, are in vogue.
On Friday, two foreign investors bought a 40% stake in the General Motors Building, a 50-story Manhattan icon that is now valued at $3.4 billion, making it likely the most valuable office building in the country. On the same day, Crown Acquisitions and Highgate Holdings reached a deal to pay $1.3 billion for 650 Madison Ave., a block north of the GM Building. Also last week, Boston Properties and its partners sold 125 W. 55th Street—a more than 550,000-square-foot tower—according to CBRE Group Inc., which brokered that sale as well as that of the GM Building.
More deals are in the works.
As real-estate mogul Mort Zuckerman's Boston Properties tries to woo more tenants for a glass tower under construction in Midtown Manhattan, he's hit pay dirt again with his initial renter.
Morrison & Foerster, the law firm which last year agreed to take seven floors in the 40-story building, will take another floor at 250 West 55th St., the firm said on Monday. All told, the firm now plans to occupy more than 20% of the building.
Progress at Boston Properties' project is being closely watched in New York real-estate circles because it is one of the rare office developments under way in Manhattan in the wake of the financial crisis. The building is slated to open in 2014 and would be Midtown's first new office building in about three years.
Microsoft Corp. and two law firms are among the tenants who have eyed Boston Properties' 40-story office tower project in Manhattan, which passed a milestone last week on its way to becoming the first new Midtown office building in three years. The 1.1 million square foot tower, known as 250 W. 55th St., was "topped out" last week, meaning the last beam was placed at the top of the building.
Now Boston Properties is hoping to lease it up before its scheduled opening in 2014. About 20% of its space already is spoken for by law firm Morrison Foerster. Microsoft would be a great get. The software giant is looking for space for its New York office, which is now on Sixth Avenue.
Microsoft also is looking at other possibilities besides 250 W. 55th St., including 51 Astor Place, according to people familiar with the matter. At the same time Boston Properties has danced with many prospective tenants.
Today's Journal looks at how the growing tech sector has been a bright spot in the national office market, with growing social media and web companies filling up buildings far from booming Silicon Valley. But in an interesting twist, it's not the traditional central business districts that are reaping most of the benefits. Instead, it's been more off-beat locations with generally cheaper rents.
In the Boston area, for instance, Cambridge, Mass. has become a hot spot for tech companies, as seen by Google Inc., which is looking to grow by about 70,000 square feet to a total 300,000 square feet, joining companies such as Microsoft Corp. in the area. Cambridge saw rents shoot up 20% during 2011, as vacancy fell sharply to 10.8%, from 15.6% a year earlier, according to real estate services company Jones Lang LaSalle Inc.
Meanwhile in the financial district of Boston, rents rose a more modest 8.7% and the vacancy rate ticked up to 20.4% from 20.2%, according to Jones Lang LaSalle.
T.J. Gottesdiener is a managing partner of Skidmore Owings & Merrill in the firm's New York City office. Going back decades, the firm has been a giant in the New York architectural scene, particularly of office buildings, designing modernist towers including the Lever House, One Chase Manhattan Plaza and 9 West 57th Street.
Today, of the four major office towers currently rising in New York, SOM is the architect for three of them: Boston Properties' 250 West 55th Street; Extell Development's International Gem Tower; and, of course, One World Trade Center, the 1,776-foot skyscraper going up in Lower Manhattan.
WSJ: On One World Trade Center, how many stories up is it now?
A sight long missing from midtown Manhattan could be slowly returning: major new office buildings under construction.
Developer Boston Properties announced today that it has signed law firm Morrison & Foerster LLP as an anchor tenant for its planned 39-story office building on the corner of Eighth Avenue and 55th Street. Boston, which is led by Mort Zuckerman, has said previously it intends to go ahead with the building as soon as this fall, a pledge that seems that much more likely with the deal for the 180,000-square-foot lease.
"To preempt the market, the lease was negotiated and closed in less than 60 days," said Morrison partner Mark Edelstein.
As with most every city save Washington D.C., Manhattan has been something of a desert for new office construction in recent years. Outside of the World Trade Center, only one major office building—Extell Development's Gem Tower on 47th Street—is under construction, and that caters specifically to diamond merchants.
The Developments blog features exclusive news, analysis and commentary on residential and commercial real estate from The Wall Street Journal's real estate bureau. Send tips, comments and questions to email@example.com.


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Small batches of cheeses are made in local cheese houses in the heart of Lancaster County to insure superior quality with the heating process not exceeding 102 degrees. Some cheeses called raw milk cheeses are produced at temperatures up to 150 degrees which damages naturally occurring beneficial vitamins and enzymes in the cheese that exist at a high level in milk from grass-fed cows. You can be confident that cheeses with the Oasis label have been made to provide the highest content of beneficial enzymes and vitamins available.
Since our cheeses are made with milk from 100% grass-fed cows, the flavor and texture will naturally vary from season to season and even from batch to batch because the grasses in the pasture change depending on the weather. Grasses growing in the cool spring and fall are not as the same as found in the hot summer months. The farmers providing our milk and the cheese makers producing our cheese are working in harmony WITH nature so one can't expect the same consistency found in a food system that depends on chemical additives to the soil.
We think that's a GOOD THING! We know you will, too.
All our cheeses are aged 60 days. The Pennsylvania Department of Agriculture agrees, after 60 days the acids and salts in raw milk cheese naturally kill any potentially harmful bacteria that could possibly be present.
Sharp Cheeses:
Sheep Cheese:
60 N. Ronks Rd., Suite J, Ronks, PA 17572 Phone: (717) 288-2154 Fax: (717) 288-2490 Contact Us ©2014, Community of Oasis at Bird-in-Hand. All Rights Reserved.


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Have: Sealed PS3 games. Sealed Xbox 360 games. Lightly used WiiU games. XBL Points. Want: WiiU, 3DS, Vita games. Offers.
Posted 12 December 2012 - 06:51 PM
Posted 14 December 2012 - 01:33 PM
Posted 24 December 2012 - 02:44 AM
Ratchet & Clank: A Crack In Time
Tradelist (Nintendo / Sony)
(Disclaimer for Paypal: I will not send gift payment as this is a violation of both CAG and Paypal ToS, Rules, UA et cetera, nor will I cover the fees, unless it is one of Paypal's exceptions {e.g. Repayment of a purchase made for me.})
May DealSeeker continue to guide us through dark voids, lead us not into tempting terrible deals, and deliver us from EA.
Posted 31 December 2012 - 01:22 PM
Didn't see anything I'm looking for, sorry.
The articles I read seem to conjure up these images of Capcom executives sitting in a dark room with a cauldron and cackling about how no one will be able to buy this game used.
Do you really think I could start a fast food restaurant called McDonaldz and use the golden arches as my logo and get away with it?


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Mark Zuckerberg Falls Off Top 40 Richest People List
Facebook CEO's worth drops as does the site's stock
Mark Zuckerberg is rich, but not as rich as he used to be. The Facebook founder no longer appears on the list of the world's 40 richest people, according to the Daily News.
The 28-year-old CEO lost his title in less than a week - on Tuesday he was worth $14.7 billion, down from $16.2 billion on May 25.
This news come on the tail of his floundering Facebook shares since the social-networking company went public
[ALSO READ: Artist Paid in FB Stock Now Worth $200M]
When the stock debuted on the Nasdaq on May 18, it closed at $38.23 and Zuckerberg's net worth totaled $19.4 billion. It was announced today that the stock has already fallen below $30.
No. 1 on the list was Mexican telecom czar Carlos Slim Helu, (worth $67.9 billion), who is ahead of Microsoft founder Bill Gates ($60.5 billion) and Berkshire Hathaway CEO Warren Buffet ($44.7 billion).


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Tuesday, March 11, 2014 | 8:14 p.m.
Hi, (not you?) | Member Center | Sign Out
Updated: 8:43 p.m. Wednesday, May 30, 2012 | Posted: 5:57 p.m. Wednesday, May 30, 2012
Staff Report
HUBER HEIGHTS, Montgomery County —
A female driver of a red pickup truck suffered non-life-threatening injuries Wednesday when her truck was knocked on its top after a sedan collided with it at the parking lot to Aldi's on Brandt Pike.
The truck was headed north on Brandt in the curb lane at about 4:40 p.m. when a gold Cadillac pulled out too far as it exited the grocery store at 6353 Brandt and hit the passenger side of the truck, Huber Heights police Lt. Mark Lightner told News Center 7.
"There was nothing the driver of the red pickup truck could really do," he said.
The truck rolled and came to rest on a sidewalk, on its top. The driver, whose name was not released, was taken to a hospital, Lightner said. The driver of the Cadillac was not injured.
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An Edmond neighborhood is on edge as police investigate a deadly home invasion that happened just before 4 a.m. Saturday.
Edmond Police got a call from a woman saying a man broke into her home on Cobblestone Road. Before officers could arrive, police learned shots had been fired.
"While officers were en route, the officers had been updated that the intruder had been shot by the homeowner," said Edmond Police Sgt. Chad Langley. "Upon the officers' arrival, they confirmed that a male subject had been shot inside the home and the investigation is ongoing."
Police say the homeowner shot and killed the intruder, 20-year-old Marlow Wilson Jr. It's a scene that shook up neighbors in the normally quiet complex.
"It's very scary. You just don't think about it happening in your neighborhood," said neighbor Shari Mason. "My mom heard the gunshots go off, so that's what woke us up...and then we got up and there were emergency vehicles everywhere."
6/22/2013 Related Story: Police: Edmond Homeowner Shoots, Kills Intruder
Carolyn Simmons says she was startled on her last day in the neighborhood. She is moving because her husband got a new job, so she was up early packing when she heard all the commotion.
"There were some loud bangs. I thought it was a car accident," said Simmons. "This place is normally locked up, so I've never been, you know, worried about a break-in or anything because of the neighbors."
But this was just one of a string of home invasions this week. On Wednesday, burglars busted a back window to break in a home on Craig Blvd., just north of Danforth Rd. and Kelly Ave. where a 15-year-old home alone called police in a closet.
The same day, an alleged Wal-Mart thief broke into a woman's home near Danforth and Santa Fe and tried to bribe her to hide him from police. The suspects in both break-ins were caught and arrested. And like the others, Saturday's home invasion was also near Danforth Rd. but off of North Blvd.
Two children live in the Cobblestone home with their parents. Detectives were on scene throughout the day continuing their investigation.
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Eight medical students on a ski trip to Norway discover that Hitler's horrors live on when they come face to face with a battalion of undead Nazi soldiers intent on devouring anyone unfortunate enough to wander into the remote mountains where they were once sent to die. It's Easter vacation, and what better way to spend the break than skiing down the isolated hills just outside of Øksfjord, Norway? After packing their cars with enough beer and ski equipment to ensure that a good time will be had by all...more
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SCX #50400 PRO Bronze 26T Crown Gear
High durability bronze crown gear. As a guide: less crown gear teeth = more speed & more crown gear teeth = better acceleration. Fits 2.38 mm (3/32") diameter axles including SCX, Scalextric and Slot It slot cars.
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Oldsmobile 1968 442 Convertible at Auction: 400 cubic inch, automatic, 73,000 miles, beautiful muscle car, outstanding condition, bucket seats, black on black, red body... More
400 V-8, Headers, 4 Speed, Power Steering, Buckets, Console, Day Night Mirror, Soft Ray Tinted Glass (All Windows), Console Tachometer, Gauges, Factory Seat Belts... More
1970 Oldsmobile 442 W-30. Attention 442/ W30 seekers Take a closer look ! Your money will be well spent ! Burnished Gold with Black Stripes and Black... More
Clean North Carolina car, true (344) 442, Recent Frame-Off Restoration, beautiful Rallye red paint, white 442 striping, factory Parchment interior, 455 ci engine, dual... More
1969 Oldsmobile 442 Covertible; Wow! Original / Numbers matching rebuilt 400 CID,earlier code #3885010 rebuilt 4 speed, 12 bolt posi rear Tag#P7A19 near 355:1 ratio, non air,... More
1973 Oldsmobile 442, Rare V-Code, 1 of 95 Produced Numbers match L-77 455ci V8 Factory equipped Muncie M-20 4-Speed Transmission Eclipse Blue w/White Stripes Black Bucket Seat... More
1968 Oldsmoblie 442 , Convertible , 400 V8 , Matching Number Engine, A/T trans, power steering, power brakes, Factory Air, has been up dated... More
1971 Oldsmobile 442 Convertible, this was the last year that Oldsmobile would have the 442 as a separate model. Standard equipment for the 1971... More
1967 Oldsmobile Cutlass Supreme 442 Convertible This is a 1967 Oldsmobile Cutlass Supreme Convertible with the 442 package. In 1967 The 442 was a option... More
Back for the second time, this 72 Olds 442-W30 was sold from our dealership in 2007. It was restored form the ground up in... More
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gtr.dave8 3 months ago
She's perfect...!!!
Regina_Fux 3 months ago
i wanna lick his delicious dick
splifler 3 months ago
fuckin music
SophieWantsYou 3 months ago
Nthss 3 months ago
mine is pink too
benjen1989 3 months ago
cute little body
kottak 3 months ago
Lovely girl, but lame music - her sounds are much better.
landolake 3 years ago
cynthia paul
thatonedude 3 years ago
she gorgouse id fuck her so hard
thuanga 3 years ago
blondelad 3 years ago
very nice,perfect body,mmmmmm
Therh66 3 years ago
She's fucking hot, but screw the music in the background lol
mritalia 3 years ago
God, she's perfect!
kerli 3 years ago
Great video ;)
mnmlb 3 years ago
I loved her pussy and her body amanzing !!
rtkc5 3 years ago
she has a beautiful body
biotech 3 years ago
she's perfect
bellybuttonpornstar 3 years ago
She has a cute bellybutton I love it
gamergurl 3 years ago
gorgeous girl and guy! great video


text:
Chilled Wine Totes - Set of 2
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text: JBC publishing house is also specialized in anime translations from Japanese to Portuguese. Series like Saint Seiya – The Lost Canvas, Ranma ½, Fullmetal Alchemist and Dragon Ball Z had Brazilian versions made by JBC Mangas team and broadcasted by the main free and pay channels (Cartoon Network, Animax, Globo TV and Bandeirantes TV). Other famous animes, such as XXX-Holic, S.Cry.Ed, DiGi Charat, Excel Saga, Digimon Data Squad, Full Metal Panic – Fumoffu, Gantz, Galaxy Angel, Noir, Blood + and Samurai 7 also had translations made by JBC Mangas team.


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Flickr User Doug Tone [ Despite Complaints, The NJDOT Insists Progress Is Being Made [AUDIO] By David Matthau May 24, 2012 Many Jersey commuters are constantly complaining about over-crowding on trains and highways, but the head of the New Jersey Department of Transportation insists progress is being made. Read More|Comment Category: New Jersey News, News, Political News Tags: NJ, njsyndicated, road construction, Transportation Send to a friend! Print this page Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!
Viurtualtourist.org [ If You Travel Rt. 18 You Need to Read This By Matt Ryan May 4, 2012 Route 18 south will be resurfaced this summer. Find out if it's going to affect your commute after the jump! The resurfacing of six miles of Route 18 south will occur from just south of Deal Road in Ocean Township to the interchange with Route 138 in Wall Township. Read More|Comment Category: Host Posts, Weekends Tags: New Jersey roads, road construction, rt 18 Send to a friend! Print this page Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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China: Expatriate members, branches building bridge of trust
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China has allowed expatriate Church members — those holding foreign passports while residing in China — to meet together and worship while following a handful of specific guidelines and restrictions.
The expatriate members are organized into international branches and groups, under the organizational umbrella of two international districts in mainland China, with some branches comprised of members of nearly two dozen nationalities.
"China has been a great place to raise our family in the gospel and to build relationships with saints throughout the world," said Elder Anthony D. Perkins of the Seventy and first counselor in the Asia Area presidency, based in Hong Kong.
Elder Perkins' assignment is a continuation of his own experiences in China, the country being part of the Church's Asia area. Before his call as a General Authority, he resided with his family in Beijing for eight years while helping build the Chinese operations of a leading international business consulting firm.
Expatriate Church members first started arriving in mainland China in the late 1970s as diplomats with the embassy or consulate staffs of foreign countries, followed by those assigned in Chinese offices or branches of major international corporations expanding into the new People's Republic of China market.
Increased educational opportunities and exchanges followed, bringing additional foreign members as English teachers, students and guest instructors and professors to the international branches. More recently, the latest wave of expatriate members coming to China includes entrepreneurs and owners and operators of small businesses.
Currently, the Church totals 11 international branches located in nine cities for its expatriate members in China. That excludes Hong Kong, which in 1997 was returned to China and is a special administrative region of the People's Republic of China.
Overseeing a majority of the expatriate members in China, the Beijing China International District covers most of the mainland and includes the two international branches located in Beijing (the original branch was divided last year) as well as single such branches in Tianjin, Qingdao, Xi'an, Guangzhou and Shenzhen.
Split off from the Beijing District this past March, the Shanghai China International District was created to give the local expatriate Church leaders a smaller number of Church units and the ability to be closer to the members in a tighter geographical area.
The Shanghai district includes the two international branches in Shanghai and one each in Suzhou and Nanjing.
Both districts have responsibility to oversee small expatriate "groups" located in other cities — the groups containing only a smattering of expatriate members, usually a household or two or a handful of individuals.
Elder Perkins said the expatriate Church members who come to work in China are here because of diverse skills — government relations, education, business, leadership and linguistics — and contribute to the rapidly developing, ever-changing nation.
"There are outstanding people being assigned by their employers," he said. "This is [China's] economy attracting the people."
But since most of the expatriate members are in China on a temporary assignment — with foreign governments, with companies based elsewhere or with education institutions or exchange programs — the turnover rate in membership is high. Local leaders estimate the average stay is about two and a half years.
China recognizes freedom of religious belief, but it requires any religious activities comply with Chinese laws and regulations. Only certain religions are legally recognized in China.
Understanding and complying with the unique restrictions on religious activities in China has enabled expatriate members of the Church to gain the trust of the Chinese government — a trust resulting in the members here being allowed to meet together much like others throughout the world.
The restrictions for expatriate members in China include no proselyting of any kind, no distribution of religious materials and — similar to other foreign religious groups — no invitations to Chinese nationals to join the international branches' meetings or activities.
Other differences include the branches meeting in homes or rented halls since there are no Church-owned facilities in mainland China as well as the restriction against shipping religious media materials into the country.
Church leaders in China regularly remind the expatriate LDS members here of the importance of adhering to the accepted policies and procedures, so there are no misunderstandings or missteps.
The members are also reminded there are no restrictions on Christlike living, service to others and setting a good example and that their efforts to abide by the government guidelines for religious activities while in China help the Church as it continues to build bridges of trust in China.
Church members who reside on temporary assignment in the People's Republic of China speak positively about their cultural experiences and the friendliness of the Chinese people.


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256 Bytes is a small cap techno font inspired by the logo for one of the first home computers: the Altair 8800. It's ideally suited to tech blog headlines.
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SOFFE Juniors' Soffe Dri Capris
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Keep moving in the cutest comfort! These juniors' SOFFE® Dri capris are designed with a low-rise compression fit, while the flacklock seams minimize chafing; moisture-wicking material helps you stay dry when your workout heats up.
Get your new SOFFE® capris today from Sports Authority.
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Product Reviews
Reviewed by 1 customer
Displaying review 1
- Comfortable
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Best Uses
Comments about M J SOFFE SOFFE Juniors' Soffe Dri Capris:
I have a hard time finding capris/running pants that fit me well, as I have slim hips and thighs, a flat rear, and carry my weight in my tummy. So, I need a mid-rise. Plus, I'm not a fan of knee pants, as I like my capris to hit mid-calf. So, these are near perfect!
I have a pair of the "Catch Me Capris" that fit me so great, but I don't wear them to work out in, because of the material. But I will these!
I've also been looking for a pair of pretty bright pink capris, and couldn't believe it when I saw these! PLUS, they were on sale!!! (even though the regular price is great too.)
The only complaint, is they "just" fit. If I went up a size, they'd be slightly too big. They fit nice and tight around my legs and the waist is a good fit as well (mid-rise), but also, "just" fitting -- i.e. there's not much room for weight gain!
We'll see how these hold up while working out and after washing. Hope they do well in both areas!
- Waist:
- Feels true to size
- Length:
- Feels true to length
- Was this a gift?:
- No
Displaying review 1


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Exterior Receiver Amplifier- Black Finish
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Product Number: | HPREL105 |
Item Price: | $103.99 |
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Shipping Weight: | 5.99 lbs. |
Due to limited supplies, and high demand this item has a 2 piece maximum order quantity per customer, every 1 day.
Best choice for light bullet applications in .222 Rem, .223 Rem .22-250 Rem and key bench rest calibers. Also great in light bullet .308 Win loads.
Hazmat shipping fee applies - $28.50 handling charge per 50 Lbs.
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For Your Consideration: Some Tips for New Bloggers
When I started this blog I was almost certain it would fizzle out in a matter of weeks. But here I am, just a little past four years, and I can not imagine my life without this wonderful place. So much has transpired since the day I sat at Coffee Cartel in the Central West End of St. Louis and started writing.
In the beginning it was just an exercise and now it has become my life (or at least a very big part of it.) There are a million different reasons why you might blog... but a few key things that can help you along the way.
There's an ongoing debate in the blogging community about how real is too real. Some bloggers choose to share very little if anything about their personal lives. While others maybe share a little bit too much. And some of us just proceed with caution and only share certain things. Being real with your readers can be a really beautiful thing that will attract people to your blog but it can also do some damage. You need to decide for yourself what kind of blog you want to have. Share only what you're comfortable with putting out there into the world for all to see and be prepared for any backlash or negativity that might come your way. It is what it is and you have to have somewhat of a thick skin.
It kind of kills me sometimes to think about all the time I wasted (especially early on) comparing myself to other more popular bloggers. Be uniquely you and only blog about things you love and at the end of the day, even if your stats don't measure up to that other blog, you will at least have the satisfaction of knowing that you didn't waiver from your own creative instincts. Ultimately, people will love you for it.
This is a really tough one, trust me I know. The wide majority of bloggers play the waiting game for at least a year before seeing significant growth on their blog. There is no tried-and-true formula for creating a blog with massive overnight success. The quality of your content or originality of your brand does not necessarily have anything to do with the speed at which the traffic to your blog grows. As with any dream or passionate pursuit, you must persevere.
I hope these tips were helpful for you! It's a topic that I could blog about for weeks and still not cover everything, so if you have any questions or need help with something leave me a comment and I'll get back to you pronto.
7 comments:
Thanks so much for this, my blog will be up and running in a couple of week (hopefully). And I'm so nervous to say the least. I do absolutely compare myself to others, not only what I plan on blogging about but the way my blog looks. I want it to suit me in every way possible but I have trouble when I compare those whom I admire. Thanks for the advice :)
ReplyDeleteThanks for these tips! I have to keep reminding myself that my blogging, shop and dreams of self-employment will take time, but I feel like Veruca Salt - "I want it NOW!"
Isn't it funny, no matter how many times you read "it takes time" you still feel like you're doing something wrong, or you're not good enough. Stupid self-doubt. Thanks for the tips
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My Front Yard :) by ! ! ! Anice ! ! Bommerscheim
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Evening Enchantment by Kori Hudson
Funeral Portrait. by Jaqueline Vanek
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mercado juarez by Ricardo Ganem
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California Pet Pharmacy |
1509 Reviews
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Product Details
NAIL CLIPPER. Made of stainless steel. Made for heavy duty. Large size.. UPC : 076681007676. Color : GREEN. Size : LARGE. Length : 8.875. Width : 2.875. Height : 0.75. Product Type : Dog - Grooming / Nail Care. Shipping Dimensions: 8.875x2.875x0.75
Product Title: Millers Forge Inc - Nail Clipper- Green Large - 767C
Manufacturer: Millers Forge
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Power Score: 4.9 | 28 Reviews
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Within the past year, my cat clippers became dull and it was obvious I needed to buy a new pair. I ordered a different brand and the new unit didn't cut through the nail, instead it splintered it. Needless to say, my cats weren't very happy about this. So, I ordered another nail clipper....same thing. Then, finally, I purchased Millers Forge Pet Nail Trimmer and "voila".....a clean cut and now...
Read Full Review
By Atlas on PETCO - Feb 25, 2012
Great clippers
These clippers do a great job making a clean cut of nails. They are a little awkward to handle, but it is worth it for the very clean and quick "snip" that they deliver! I had tried other more expensive clippers, but they tended to bend the claw or make a jagged cut. These do a much better job.
By LuvShoes on PETCO - Jan 3, 2012
Great value
We had bought a different nail clipper that cracked/split our puppy's nails. Bought this as a replacement based on customer reviews, and we agree: cuts cleanly and easily. I like the little guard to protect against unexpected movements, and the lock to keep the clipper closed when not in use. Overall, very happy with the purchase.
By FirstPuppy on PETCO - Jun 25, 2011
Nice & Sharp
Nice and sharp for trimming dog nails. The guard on the clippers get in they way, Nail clipping tend to get stuck in the nail guard.
By NKJK627 on PETCO - Apr 29, 2011
After struggling for years to get my very large mixed breed Great Dane's nails clipped...I finally found the solution! Even my vet and his assistant could never get Bogie's nails cut...it was a very big deal. I tried other clippers to no avail. They took all my strength to squeeze down and cut, not to mention, the dog would not sit still while I gritted my teeth and strained to make a cut. More...
Read Full Review
By bogiesmom on PETCO - Feb 4, 2011


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J.L. Elson, D.M. Turnbull and Neil Howell
AbstractThis article provides evidence that selection has been a significant force during the evolution of the human mitochondrial genome. Both gene-by-gene and whole-genome approaches were used here to assess selection in the 560 mitochondrial DNA (mtDNA) coding-region sequences that were used previously for reduced-median-network analysis. The results of the present analyses were complex, in that the action of selection was not indicated by all tests, but this is not surprising, in view of the characteristics and limitations of the different analytical methods. Despite these limitations, there is evidence for both gene-specific and lineage-specific variation in selection. Whole-genome sliding-window approaches indicated a lack of selection in large-scale segments of the coding region. In other tests, we analyzed the ratio of nonsynonymous-to-synonymous substitutions in the 13 protein-encoding mtDNA genes. The most straightforward interpretation of those results is that negative selection has acted on the mtDNA during evolution. Single-gene analyses indicated significant departures from neutrality in the CO1, ND4, and ND6 genes, although the data also suggested the possible operation of positive selection on the AT6 gene. Finally, our results and those of other investigators do not support a simple model in which climatic adaptation has been a major force during human mtDNA evolution.
Abstract | Full Text | PDF (392 kb) - …more
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Trends in Parasitology, Volume 20, Issue 8, 388-395, 1 August 2004
Assessing the effect of natural selection in malaria parasites
Ananias A Escalante1, 2, , Omar E Cornejo1, Ascanio Rojas1, Venkatachalam Udhayakumar2 and Altaf A Lal2
1 Instituto Venezolano de Investigaciones Cientı́ficas, Apartado 21827, Caracas 1020-A, Venezuela
2 Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Mail Stop F-12, 4770 Buford Highway, Chamblee, GA 30341, USA
There are few concepts that have been used across disciplines; one of them is natural selection. The impact that this process has on parasite genetic diversity is reviewed here by discussing examples on drug resistance and vaccine antigens. Emphasis is made on how mechanisms need to be addressed rather than associations, and how such investigations were out of reach of biomedical researchers only a decade ago.


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Wednesday, August 3
The Ultimate Art Machine
Is the Guggenheim the Shake Shack of museums? Locations, locations, locations! Not content with outposts in the Basque Country and the United Arab Emirates (as well as the now-shuttered Las Vegas outpost, which seems in retrospect a bit of an overreach…to expect real culture to take hold in the land of bilk and money), the Guggenheim is now creating a mobile lab, opening today, that will set up shop in nine cities over six years in a quest to spur discussion on urban life. The slow migration of the auto-company-sponsored BMW Guggenheim Lab (a mobile laboratory isn't cheap, dears!) begins in New York with the erection of a mobile structure themed around "Confronting Comfort." (While the Guggenheim Lab is referring to balancing individual desire with the common good, surely you'll be reminded that a new BMW forces you to "confront comfort" in a whole new way!) Catch it while you can—the mobile lab jaunts to Berlin next, then on to a yet-to-be-announced city in Asia.
BMW Guggenheim Lab, 33 East First Street, opens today from 1-9pm, visit guggenheim.org for more information.
Thursday, August 4
Single-Source Stories
When we hear "Talking Head," we think rock star/bicycle enthusiast David Byrne, of course—we see that guy everywhere! But some talking heads come on reels, not wheels: the Anthology Film Archives continue their Talking Head screening series of documentary films featuring testimonials from a single individual. The mini-genre's rife with unreliable narrators and charismatic characters: today brings screenings of The Confessions of Winifred Wagner (about Richard Wagner's daughter-in-law and her friendship with Adolf Hitler) and Martin Scorsese's Italianamerican and American Boy (regarding, respectively, his parents and the Taxi Driver actor Steven Prince).
Anthology Film Archives, 32 Second Avenue, The Confessions of Winifred Wagner at 6:45pm, Italianamerican and American Boy at 9pm, visit anthologyfilmarchives.org for tickets and information.
Friday, August 5
This weekend, the Shinnecock Indian reservation, in Southampton, is invaded by hordes even wilder than cigarette buyers looking for a tax-free carton. The Escape to New York music festival brings electro-loving ravers in for a weekend spent sleeping in campers (it's glamorous camping, or "glamping," for the Sunday Styles set), listening to music and enjoying all the good, clean fun the Hamptons have to offer. Tonight, noted memoirist Patti Smith and girl-group-but-not-in-the-Phil-Spector-way Best Coast perform on the main stage. It's not just music and glamping (something about that word—we just can't take ourselves seriously when we say it!): the organizers were responsible for the U.K.'s Secret Garden Party, an annual festival that transforms a manor house's grounds into what a Telegraph reporter described as "a fairy woodland filled with strange sculptures" and "a Tower of Babel disco." If this all sounds a bit foreign to you, gentle partygoing reader, know that in bringing a manic all-weekend festival to the States, the organizers adopted one indigenous custom: there will be a massive brunch for all attendees. Glamorous!
Escape to New York runs through August 7, Shinnecock Reservation (Southampton), visit escape2ny.com for tickets and information.
Saturday, August 6
Newport Lights
If you find yourself among the Gilded Age relics in Newport tonight (we mean the mansions, not the social set), contribute to the preservation of one grand home. Once owned by Pennsylvania coal baron Edward Julius Berwind and modeled after a French chauteau, the house at the Elms is fine ($1.4 million in 1901 money could buy you a pretty sturdy house), but its carriage house and stables are in need of a pick-me-up. Tonight's black-tie dinner dance—whose theme is "A Midsummer Night's Dream"–will raise money for Newport's Preservation Society, which plans to turn the stables of The Elms from equine domicile into a historical society devoted to researching the town's architectural history. Let's make sure that horsey smell is powerwashed out before the important work of this research center begins!
The Elms, 367 Bellevue Avenue (Newport, R.I.), 7pm, call (401) 847-1000 x120 for reservations.
Sunday, August 7
McQueen for a Day
The Met is open until midnight tonight so that late, late latecomers can check out Alexander McQueen's wares before the exhibit closes permanently. A night spent experiencing the glories of the museum? We remember that children's book! Most everyone we know has raved about the Costume Institute show, but we've been pretty busy all summer (the Newport mansions can't save themselves, you know, and there's pretty intriguing costumery to check out there as well!), and the museum's been bending over backwards to accommodate busy (lazy!) people like us all summer, with admission on Mondays and now late-night shows. Is any innovation quite so welcome in this go-go city as a museum for the nocturnal? We hope the trend catches on—nothing would lull us to sleep quite like the soft glow of MoMA's Rothkos. (We do love McQueen, too, but we're sure those severe, radical clothes will give us a few nightmares!)
Metropolitan Museum of Art, 1000 Fifth Avenue, exhibition open until 12am August 6 and 7, visit metmuseum.org for more information.
Monday, August 8
Day for Night
We're still vicariously embarrassed for dear old drama geek Anne Hathaway in her noble, pathetic attempt to host the Oscars by sheer force of will. She tried so very hard! She laughed at her own jokes to fill cavernous silences! Well, her new film might have put the brakes on her earnest, overbearing schtick and given us the chance to remember why we loved her in the first place. Ms. Hathaway, as a British lady separated from her one true love but for an annual brief encounter, puts her high-school-production-of-Oliver! on for the new film One Day, which she's fêteing at the red carpet premiere tonight. Do you think Ms. Hathaway's erstwhile Oscar co-host James Franco would consider it a suitable art project to come as our plus-one?
One Day premiere, an Upper West Side movie palace, screening at 7pm.
Wednesday, August 10
Rangel Me an Invite
It's Christmas for politicos with the annual Charles Rangel birthday gala (the Congressman was born in June, but that's not a slow news month that will guarantee headlines!). Planned attendees at the Plaza Hotel bash include Governor Andrew Cuomo, Senators Kirsten Gillibrand and Charles Schumer, and Manhattan Borough President Scott Stringer—all familiar faces from last year's bash, which went on during Mr. Rangel's ethics investigation. Also planning to attend is Aretha Franklin, who'll sing for the assembled guests: she was supposed to sing last year, but fell and broke her ribs, so Psychic Friend Dionne Warwick turned up instead. Broken ribs are perhaps the only excuse that can keep prominent machers away from the ever-popular Mr. Rangel: "I felt bad—because Aretha felt so bad!," said Mr. Rangel's fundraising consultant Darren Rigger, who noted that Ms. Franklin was pleased to make up for her truancy. As for the party–why the Plaza and not, you know, something in Mr. Rangel's district? "Charlie is iconic," said Mr. Rigger. "We needed a place that had that same feel—you remember the Black and White Balls, the galas, it sends a powerful message. There's a lot of places, and I'm not going to say bad things about other places, but this place is iconic for throwing a gala." Indeed! If Truman Capote were alive today, he'd love nothing more than hanging out with New York politicians.
Plaza Hotel Grand Ballroom, Fifth Avenue at Central Park South, 6pm-8pm, visit charlierangel.org for tickets and information.


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in the deep night of our bedsdesire walks barefoot through passionsand imaginingsdrawn of endless hoursetching into my daysthat no longer rememberthe timebefore,you were there. your touch flowsto the centre of my sexbeckoning the godsto dance divine the spectacle burrowed in the seasonsof my heart. your jewelled adorationshimmers the lengthof your affectionsthat i may lose my mindto the fragranceof all you have becometo me.
She has dealt with (this) exile by delving deep into the written word, both in fiction and in poetry. The exploration of her prose, which is also excellent, comparing with the works of Alexander Solzhenitsyn, si for another time. In her poetry we find a combination of eloquence and love for the English language that approaches that of T.S.Eliot. (Roger Humes, Curator Other Voices)"
—Preface, Sexions, selections from life and love
About Renee
I was born and educated in South Africa during the 'golden era' of Apartheid. I grew up somewhere between the stables, the stage and the dance studio. My young world was shaped by storytellers yet, I would never have considered writing at all had it not been...
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Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This study will compare two different treatments of acute alcoholic hepatitis. The current standard of care is treatment with corticosteroids (methylprednisolone). This will be compared to treatment with anakinra, pentoxifylline, plus zinc sulfate. The participants will be treated and followed for 6 months and the two treatment groups will be compared for differences in death rates and laboratory tests that measure liver and gut function.
Condition | Intervention | Phase |
Acute Alcoholic Hepatitis |
Drug: Anakinra Drug: Pentoxifylline Drug: Zinc Sulfate Drug: Methylprednisolone |
Phase 2 Phase 3 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Caregiver, Investigator) Primary Purpose: Treatment |
Official Title: | Double-blind Randomized Controlled Trial of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis |
- Death [ Time Frame: Time to event up to 6 months ] [ Designated as safety issue: Yes ]Mortality
- MELD score [ Time Frame: 30, 90, and 180 days ] [ Designated as safety issue: Yes ]Model of End Stage Liver Disease Score calculated from serum bilirubin, serum creatinine, and the international normalized ratio for prothrombin time (INR)
- Laboratory assay for biomarkers of inflammation [ Time Frame: 2,7, 30, 90, and 180 days ] [ Designated as safety issue: No ]Serum endotoxin, IL-1, TNF-alpha
Estimated Enrollment: | 130 |
Study Start Date: | August 2013 |
Estimated Primary Completion Date: | December 2015 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Anakinra & Pentoxifylline & Zinc Sulfate
anakinra 100mg subcutaneous injection daily for 14 days pentoxifylline 400 mg orally three times daily for 30 day zinc sulfate 220 mg orally for 180 days
Drug: Anakinra
Anakinra, interleukin-1 receptor antagonist; 100 mg/0.67 mL solution for subcutaneous injection.
Other Name: Kineret
Drug: Pentoxifylline
Pentoxifylline, generic
Other Name: Pentoxifylline, generic
Drug: Zinc Sulfate
Zinc Sulfate, nutritional supplement
Other Name: Zinc Sulfate, generic
Active Comparator: Methylprednisolone
methylprednisolone 32 mg orally daily for 28 days
Drug: Methylprednisolone
Methylprednisolone, corticosteroid
Other Name: Methylprednisolone, generic
Detailed Description:
This study will test the hypothesis that the syndrome of acute alcoholic hepatitis results from severe inflammation and dysregulated cytokines. Steroid monotherapy is not effective in all patients and this study will utilize compounds that have the potential to improve gut barrier function, to reduce the associated inflammation, and to prevent the development of hepatorenal syndrome and other organ failure.
Patients will be randomized to receive 28 days of methylprednisolone 32 mg daily OR therapy that includes a combination of anakinra (interleukin-1 receptor antagonist) 100mg by subcutaneous injection daily for 14 days plus pentoxifylline 400 mg orally three times daily for one month plus zinc supplements (220 mg of zinc sulfate) given orally for 6 months. This combination strategy will address the acute inflammatory component of the disease (anakinra) and protect against development of hepatorenal syndrome (pentoxifylline), one of the most frequent causes of death in severe acute alcoholic hepatitis, and improve gut mucosal integrity (zinc supplements). The primary outcome will be 6 month mortality rate. Secondary outcomes will be measured at 30, 90 and 180 days.
Ages Eligible for Study: | 21 Years to 70 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Ability to provide informed consent by subject or appropriate family member
- Age between 21-70 years
- Recent alcohol consumption > 50 g/d for > 6 months, continuing within 2 months before enrollment
- At least 2 of the following symptoms of acute alcoholic hepatitis: anorexia, nausea, RUQ pain
- Liver biopsy diagnostic of acute alcoholic hepatitis or at least 2 of the following: jaundice, leukocytosis, hepatomegaly
- Elevation of AST > 80 U/L, but < 500 U/L; AST > ALT and ALT < 200 U/L; total bilirubin > 3 mg/dL
- Ultrasound or CT scan suggesting fatty infiltration of the liver OR liver biopsy showing alcoholic hepatitis
- Model for End-Stage Liver Disease (MELD) ≥ 21
Exclusion Criteria:
- - Hypotension with BP < 80/50 after volume repletion
- Pregnancy; incarceration; inability to provide consent or lack of appropriate family member
- Signs of systemic infection: Fever > 39° C; positive blood or ascites cultures within 3 days of inclusion
- Acute gastrointestinal bleeding requiring blood transfusion within the previous 4 days
- Undue risk from immunosuppression: Positive HBsAg; a positive skin PPD skin test or history of treatment for tuberculosis; history of any malignancy including hepatocellular carcinoma; HIV infection
- Previous treatment with corticosteroids or other immunosuppressive medications including anti-TNF therapy, calcineurin inhibitors within the previous 3 months
- ANA > 1:160; anti-smooth muscle antibody > 1:40; cryoglobulinemia; positive anti-CCP or rheumatoid factor
- Evidence of acute pancreatitis: CT evidence or amylase or lipase > 4 X ULN
- Serious cardiac, respiratory or neurologic disease or evidence of other liver diseases such as autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, Wilson disease, hemochromatosis, alpha-1-antitrypsin deficiency
United States, Kentucky | |
University of Louisville | Not yet recruiting |
Louisville, Kentucky, United States, 40202 | |
Contact: Craig J McClain, MD 502-852-6991 | |
Principal Investigator: Craig J McClain, MD | |
United States, Massachusetts | |
University of Massachusetts Medical School | Not yet recruiting |
Worcester, Massachusetts, United States, 01655 | |
Contact: Gyongi Szabo, MD 508-856-5275 | |
Principal Investigator: Gyongi Szabo, MD | |
United States, Ohio | |
Cleveland Clinic | Not yet recruiting |
Cleveland, Ohio, United States, 44195 | |
Contact: Arthur J McCullough, MD 216-444-2766 | |
Principal Investigator: Arthur J McCullough, MD | |
United States, Texas | |
University of Texas Southwestern Medical Center | Not yet recruiting |
Dallas, Texas, United States, 75390-9030 | |
Contact: Mack C Mitchell, MD 214-648-5036 | |
Principal Investigator: Mack C Mitchell, MD |
Principal Investigator: | Mack C Mitchell, MD | University of Texas Southwestern Medical Center | |
Principal Investigator: | Arthur J McCullough, MD | The Cleveland Clinic | |
Principal Investigator: | Craig J McClain, MD | University of Louisville | |
Principal Investigator: | Gyongi Szabo, MD | University of Massachusetts, Worcester |
No publications provided
Responsible Party: | Mack Mitchell, Professor of Medicine, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center |
ClinicalTrials.gov Identifier: | NCT01809132 History of Changes |
Other Study ID Numbers: | U01-AA021893-01, U01AA021893-01 |
Study First Received: | March 8, 2013 |
Last Updated: | August 9, 2013 |
Health Authority: | United States: Food and Drug Administration |
Keywords provided by University of Texas Southwestern Medical Center:
Hepatitis, alcoholic pentoxifylline zinc anakinra |
glucocorticoids MELD score Intestinal mucosa |
Additional relevant MeSH terms:
Hepatitis, Alcoholic Hepatitis Hepatitis A Liver Diseases Digestive System Diseases Liver Diseases, Alcoholic Alcohol-Induced Disorders Alcohol-Related Disorders Substance-Related Disorders Hepatitis, Viral, Human Virus Diseases Enterovirus Infections Picornaviridae Infections RNA Virus Infections Methylprednisolone acetate |
Prednisolone acetate Methylprednisolone Methylprednisolone Hemisuccinate Prednisolone Prednisolone hemisuccinate Prednisolone phosphate Pentoxifylline Zinc Zinc Sulfate Interleukin 1 Receptor Antagonist Protein Anti-Inflammatory Agents Therapeutic Uses Pharmacologic Actions Antiemetics Autonomic Agents |
ClinicalTrials.gov processed this record on March 13, 2014


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For immediate release
July 10, 2009 |
WASHINGTON – Georgetown University announced today that it received a $20 million gift to name the new building for its McDonough School of Business in memory of the late Rafik B. Hariri -- a two-time prime minister of Lebanon, renowned philanthropist and dedicated supporter of education.
The gift was made by Hariri's son, Saad Hariri, the newly designated prime minister of Lebanon and a 1992 alumnus of the McDonough School of Business. It will help cover the final costs of constructing the new building, which will begin holding classes for all business school students in September. In addition to supporting the Rafik B. Hariri Building, the funds also will create two endowed scholarships, one each for an undergraduate and a graduate student.
"This gift will make a tremendous difference in our ongoing efforts to enhance Georgetown's global business education programs," said Georgetown President John J. DeGioia. "I am deeply grateful to the Hariri family for their generosity in supporting two of our most important priorities -- building and maintaining first-class facilities and providing financial aid for students to study at Georgetown."
Rafik Hariri was a dominant political and entrepreneurial figure for decades in Lebanon before his assassination on Feb. 14, 2005. A staunch U.S. ally and a visionary who sought to bring peace and democracy to Lebanon, Hariri was prime minister from 1992 to 1998 and again from 2000 to 2004. One of his primary achievements was ensuring that Beirut, the capital, was rebuilt and restored to its former vibrancy following the country's devastating 15-year civil war.
A self-made billionaire who made his fortune in the construction industry, Rafik Hariri also was a dedicated philanthropist. In 1979, he founded the nonprofit Hariri Foundation, which has helped tens of thousands of Lebanese students attend institutions of higher learning at home and abroad and provided health, social and cultural services to Lebanon's neediest. The Hariri Foundation-USA, located in Bethesda, Md., has helped thousands of Lebanese scholars advance their studies at more than 300 colleges and universities in North America.
Rafic Bizri, president of the Hariri Foundation-USA, said "the gift that Saad Hariri has made to Georgetown University truly honors Rafik Hariri's extraordinary devotion to the great cause of education. It expresses the son's profound regard for his father and pays tribute to the ultimate sacrifice, which Rafik Hariri made for his country."
As a Georgetown parent, Rafik Hariri was a generous supporter to the university and served on the business school's Parents Council. Georgetown awarded him an honorary degree in 1996, hailing the prime minister as "a champion of education and opportunity for the underprivileged."
Saad Hariri, the second son of Rafik Hariri and Nidal Al-Bustani, has followed in his father's footsteps as both an entrepreneur and statesman. Before becoming Lebanon's prime minister designate, he served as majority leader of the Lebanese Parliament and as general manager of Saudi Oger Ltd., his family's multibillion-dollar construction company.
In reflecting on his father's singular contributions to the welfare of Lebanon, Saad Hariri said, "among the many attributes for which my father, Rafik Hariri, is remembered, his commitment to education and the pursuit of excellence was dearest to his heart. Inspired by this commitment, he made it possible for tens of thousands of Lebanese students to pursue their education at home and abroad. Today, these Hariri alumni are the true wealth of Lebanon, the best part of his legacy to his beloved homeland. I am proud to be part of such a legacy and to dedicate this gift to Georgetown University to the memory of Rafik Hariri."
"Saad Hariri's generosity to Georgetown will establish a lasting tribute to his father and result in a world-class facility for our business students and faculty," said George Daly, dean of Georgetown's McDonough School of Business. "We are excited about the opportunities this new state-of-the-art building will provide to our community members as they engage in the many facets of a business education."
The Hariri family's connections to Georgetown run deep: Saad Hariri's brother Ayman Hariri is a 1998 graduate of Georgetown College and another brother, Addy Al-Shaikh, attended Georgetown Law Center.
The new Rafik B. Hariri Building is a 179,000-square-foot facility in the center of Georgetown's campus that will enable the McDonough School of Business to solidify its position as one of the world's leading business schools. This new home for the business school features seminar, lecture and conference rooms; a 400-seat auditorium; eight case rooms; and common areas for both undergraduate and graduate students.
About Georgetown's McDonough School of Business
Georgetown University's McDonough School of Business is a premier business school in the nation's capital. Founded in 1957 to educate undergraduate business students through the integration of liberal arts and professional education, the McDonough School annually welcomes some 1,400 undergraduates, 1,000 MBA students, and 500 participants in its executive education programs. For more information about Georgetown's McDonough School of Business, visit www.msb.georgetown.edu.
About Georgetown University
Georgetown University is the oldest and largest Catholic and Jesuit university in America, founded in 1789 by Archbishop John Carroll. Georgetown today is a major student-centered, international, research university offering respected undergraduate, graduate and professional programs in Washington, DC, Doha, Qatar and around the world. For more information about Georgetown University, visit www.georgetown.edu.


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Saturday, January 11, 2014 12:40 PM
We are Los Angeles Gold & Silver, an established Rare Coin shop in the heart of the Beverly Hills shopping district. If you have coins that your are considering selling, or would just like more information about, then please visit us for a Free Appraisal today. With over 40 years of experience as professional numismatists (coin experts) we are uniquely qualified to give you all the information you could want about your coins. Our lead expert was the Director of Acquisitions for the largest Rare Coin auction house in the world, and knows the market very well. If you are interested in selling your coins he will make you the strongest possible offer based on todays market. This business is our passion and we are happy to share our knowledge with you. Please visit us at Los Angeles Gold & Silver 427 N. Camden Drive, Suite F, Beverly Hills, CA 90210. Free Parking directly across the street. You can reach us by phone at 310-246-4653 or visit us online at http://www.lagoldandsilver.com for more information about who we are and what we do. Become our next loyal customer, you will not be disappointed!
• Location:
Beverly Hills
• Post ID: 18521799 losangeles
Play it safe. Avoid Scammers.
Most of the time, transactions outside of your local area involving money orders, cashier checks, wire transfers or shipping (especially overseas shipping) are scams or frauds.
Report all scam attempts to firstname.lastname@example.com.


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3 Software / Web Tools to Fall In Love with
I am in the process of returning to blogging on a more regular basis again (two boys under the age of 2 can really tax your schedule!), but for the moment I wanted to at least share a few productivity tools that I have found and fallen in love with over the past year…
And not only are all 3 tools very useful, they also have basic, fully functioning versions that are completely free!!
1) LastPass – http://www.lastpass.com
This password-memory tool appears to be the industry leader. It bills itself as the "last password you will ever need" — you do, in fact, log in once and then worry no more about remembering passwords. LastPass is smart– when you are in a website sign-up page asking for a username, password, etc., Lastpass offers you the choice to have it generate a unique, secure password that it will remember in its database. If you decline and enter one on your own, as you successfully hit submit/continue/etc on that page, it gently prompts you at the top of your browser to 'Save site' if this a site whose username/password you would like to retain.
LastPass has a lot of different features- AutoFill, AutoLogin, and even multiple form-field profiles to save common sets of information you may find yourself entering on websites of all kinds (think 'home address', 'business address', even payment info, etc.). There are plug-ins for multiple browser types, and even an iPhone version. Though I've not yet tried the iPhone plugin, I imagine that it will be immensely helpful. Not only is entering usernames/passwords in iPhone's Safari often cumbersome, it's an even more grueling process if you have to go through a Forgot Password routine! LastPass helps you avoid both scenarios.
2) Adolix split and merge PDF – http://www.adolix.com/split-merge-pdf/
Talk about a paperless office has been almost constant now for the last 10-15 years — and yet, from my own experience, it has just been the last 2-3 years that the mainstream business world is really grabbing hold of this concept. True, digital signatures have not yet taken over as a preferred method of signing over a signature, but on the few things that still require signatures, the printed and then signed document quickly becomes digital again for the purpose of emailing over to a colleague, customer, vendor, or other party expecting the quick arrival of the signed document. In this new world of electronic documents – largely dominated by MS Word format documents in the sphere of 'editable' formats, and especially in the world of imaged documents dominated by the Adobe PDF file format, there is need for easier management of not just files, but also PAGES.
How many times have you needed to pull out pages 3-4 of a 20-page pdf contract to email to someone? What do you do? You probably either email them the whole file and hope they can find the sections you need to emphasize to them, or you laboriously print out the relevant pages out of the larger PDF, scan them back into your computer, and email the new, smaller PDF file. Painful, eh?
Enter Adolix. They have created a very helpful utility that allows you to quickly split out pages of a PDF document.
How about combining PDF's? Or combining pages 1-2 of one PDF file, and then pages 7-10 of the next file? You can use the utility's split tool to first pull out the relevant pages, and then use its MERGE tool to combine the two newly formed PDF's into one new file. And, if you use this tool in conjunction with a PDF creator such as Adolix's own "PDF Converter" utility, or my personal favorite CutePDF (http://www.cutepdf.com/), you can easily take a number of files in different format (a Word document here, an Excel document there, a PDF document there), convert the non-PDF files into PDF's, and then combine them withoT Adolix!
3) Mikogo - http://www.mikogo.com/
After being tired of essentially being tied to GoToMyMeeting, GoToMyPC, or WebEx for years, I finally spent some time googling around about a year go to find a free solution for screen sharing and web conferencing. I was very happy to come across Mikogo. Mikogo was developed by a company that sells high-end virtual conferencing solutions — a company that now appears to have moved into the GoToMy____ space.
Again, the Mikogo product is FREE, and I have found works just as smoothly as any of the other solutions out there– additionally, I found that the app that runs resident in the system tray does not bog down your computer's memory or processor, and the features that come in Mikogo are equal to or even better than those found in comparable and more popular utilities.
Now if they could only change their name to something less nonsensical…
I hope that this review of these tools has been helpful!
One Response
Hi Phil,
Thanks a lot for taking the time to review and share your experiences of Mikogo. Glad to hear that you're liking our remote desktop app for web conferencing!
Btw, Mikogo is a Swahili word that means to "to present" or "to show" which is where the name came from for a screen sharing app.
We're working on Version 4 of the software which will include even further features!Regards,
Andrew Donnelly
The Mikogo Team
Twitter: @Mikogo


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The Golden Eagles boast a strong backcourt led by first-team All-WVC guard Terrell Lipkins.
Lipkins leads the team in scoring (17.1 points per game), assists (4.6), steals (2.3) and is second in rebounding (5.1).
The strength of the Yellow Jackets comes from strong post play led by Anton Hutchins (15.3 points, 5.1 rebounds), David Ford (10.7 points, 6.5 rebounds) and Raymon Austin (10.7 points, team-leading 8.5 rebounds).
This season has been a struggle for Poore's team, which has one winning streak of two games and has three losing streaks of at least three games each.
The Yellow Jackets take a three-game losing streak into tonight's meeting with losses at Concord (81-77), at Bluefield (96-95, OT) and at home against UC.
As for the Golden Eagles, they are in the same position as other WVC teams, likely needing to win the WVC Tournament to entertain hopes for a berth in the NCAA Division II Atlantic Region.
"I like where we are right now in terms of the way we're playing," said Downey, whose team's only loss in the last four games was a double-overtime defeat to Wheeling Jesuit.
The latest Atlantic Region standings, released Feb. 20, have West Liberty No. 1, Fairmont State No. 3 and Alderson-Broaddus No. 7. Wheeling Jesuit was No. 10 prior to losing to West Liberty in the regular season finale.
Last season four teams - West Liberty, Wheeling Jesuit, Charleston and West Virginia Wesleyan - earned spots, with the field rounded out by Pennsylvania State Athletic Conference member East Stroudsburg and Central Intercollegiate Athletic Conference member Winston-Salem State.
Contact Assistant Sports Editor Rich Stevens at richstev...@dailymail.com or 304-348-4837.


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By: Sam Doerr
There could be big changes coming to medicare all across the United States. A federal agency is proposing a change to the way some rural facilities like Sanford Vermillion are classified. If classified as a critical access hospital they get reimbursed for 101 percent of their costs of treating medicare patients. But that federal agency wants to take away that designation if a hospital is less than 35 miles from another facility. "What it would mean for us is diminished access for patients we would be making decisions on what we can provide and we can't provide" says Sanford Medical Clinic Vermillion CEO Tim Tracy. South Dakota's Health Secretary Doneen Hollingsworth has been outspoken against the measure. "I actually think it's a ludicrous proposal and I can't tell you the rationale behind it." 60 percent of the current patient base in Vermillion is medicare based says Tracy. "When we went critical access when we certified in 2004 the financial analysis that we did said that the reimbursement would increase by 200-250 thousand dollars, but that was in 2004 today that would be a million dollars." The proposal is in it's infant stages and would take congressional action. The state of South Dakota says it will fight the proposal.


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In my mind there are several key elements important to a good cart. These include (but are not limited to and not in any order):
Great subject louponne! :)
The big conundrums are the GUIs for both the visitor AND the admin. Many of the Open Source carts I've looked at seem to have grown out of a particular need by a programmer. They appear to be built without the help of usability testers or marketing people and in some cases, someone familiar with coding large projects for long term growth and upgrades. But these projects largely cover the basics. I think the general functionality most developers aim for are to make the carts customizable and provide a catalog/cart/shipping calc, and full CC transactions ability. After that it depends upon the particular project the cart will be used for.
I think most programmers of carts believe their product is flexible enough that anyone with enough skill can take their catalog/cart code and modify it to suit. And I think this is the crux of the issue. Just how much tinkering/customizing are you willing to do before you achieve the product you want? Everyone that wants to do eCommerce comes into it with different skill sets and desires. In your case, you have programming skills and know pretty much what you want. You can sift through the offerings and choose or build your own. A greenhorn cannot do the same without a programmer's help and might not be able to foresee issues with one cart over another and chooses one based on either someone elses input (like a programmer's or website designers), price, or because the closed their eyes and took a guess. (Gosh I'm tired of cleaning up these messes.)
There are several products that are reasonably good out of the box. None of them is good enough though. I always expect to do some modifications as I build. For me, it's a matter of choosing one that gets reasonably close to what I want and then use it as a starting point. I've pretty much settled on one cart now and use it for all of my installs unless asked to use something else. Largely because it matches the way I think and I am comfortable with it enough to make it do pretty much anything I want. But any programmer that becomes intimate with a particular cart will feel the same about it.
So we come back to - how far away from ideal are you willing to start?


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BU pediatrician named editor of leading medical journal
A professor of pediatrics and community health sciences at Boston University School of Medicine has been named the new editor of the Journal of the American Medical Association.
Dr. Howard C. Bauchner was selected as the editor of the leading medical journal after an international search, and will start the job in July. Bauchner is currently the editor of the journal Archives of Disease in Childhood. He also does research and publishes his own work, with an emphasis on clinical trials and promoting health.
"We are pleased that Dr. Bauchner will be the new editor of JAMA," AMA chief executive Dr. Michael D. Maves said in a statement. "JAMA is a world-class medical journal and we?re confident the journal will continue to grow and prosper under his leadership. The future of JAMA -- one of the AMA?s most treasured assets -- is in great hands."
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White Coat Notes covers the latest from the health care industry, hospitals, doctors offices, labs, insurers, and the corridors of government. Chelsea Conaboy previously covered health care for The Philadelphia Inquirer. Write her at email@example.com. Follow her on Twitter: @cconaboy. |
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By jrandol
via exceptionalasp.net
Published: Nov 13 2010 / 00:20
To be honest, if we were comparing a language like Ruby to C# 1.0, released not so long ago in 2002, we would be long gone. C# started out feeling like a boring Java clone but Microsoft have spent 8 years maturing it with surpisingly good taste. This is not the same language we had 8 years ago and if you haven't been paying attention it's time to take another look.