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Red Ringer Flash Gordon T-Shirt
Item # DCCOM072
Average Customer Rating:
Meet Jeremy. He is 5' 10" tall and weighs 170 pounds. He is wearing size M.
Full Description
Color: | White |
Material: | 100% Cotton |
Tag: | Tagged |
Softness: | Standard |
Fit: | True To Size |
Great Shirt!
My son loves the shirt! Great customer service!
Red Ringer Flash Gordon T-shirt
My medium-sized (M&O brand) Flash Gordon T-shirt fits perfectly. The red ringers are comfortably snug. Incredibly, as of November 3, 2011 I have yet to wear this T-shirt. Of course, I did try it on as soon as I received it though. Much obliged!
This is our second one!
This is our second one, he wore the first one out after several years and begged for another!
Red Ringer Flash Gordon Shirt
Came in great timing
quality as adverdised
i was suprised by how thick and solid the shirt appears to be. i expected a very thin lower quality. very happy with the purchase
Great T-shirt glad i got it
I wear it at least once a week and didn`t have any problems like shrinkage or anything.
At last!
I had been looking for this item for years!
Great shirt!
Great shirt! Looks just like the one in the film!
Just perfect
Awesome shirt. Get one!
I bought this shirt for a man I love very much, and seeing the expression on his face when he seen this shirt makes me very happy! I would buy this shirt again.
I would buy this product again
I bought this for a friend. Its the best gift ever. I would do it again. The look on his face was worth it all.
I would buy this again
I bought this for my boyfriend and he loved it! He is particular about material of shirts and liked this style and thickness!
It wears better than it looks!
I am very picky when it comes to tshirts. I looked at the model and specificaly, how long the sleeves look on the model. I decided to go for it anyway and I am so glad I did. I think it fits great. The sleeves are not too long! BUY IT!!! Everyone will start singing the song when you wear it. FLASH! AHHH!
Perfect accessory for Halloween!
Ordered the Flash Gordon t-shirt for a Freddie Mercury Halloween costume. High-quality shirt, thick cotton, minimal shrinkage. I'm 6'2", 180 lbs. and the medium fits perfectly. Highly recommended.
Fast and Flashy
I bought this for a gift and it was much appreciated!
I own and cherish three of these.
I've wanted this shirt since I was a little kid watching the Flash Gordon movie from 1980. When I found it on 80s Tees, I bought two just in case something happened to the first. This Halloween, while purchasing a different shirt for my costume, I said "what the heck" and bought a third just to have it. Maybe I'll frame the newest one and wear the older two for the rest of my life.
Flash! Aaaah-Aaaah!
Retro Rocks!
What a great shirt. I'm all about the retro shirt and this one fits the bill.
Nice shirt!
Great Tee, but iffy quality
I LOVE the movie and loved this shirt when I first saw it. Exactly the same as Flash wore in the movie.However, it's a little smaller than advertised and the lettering has faded pretty badly. It's no longer my "wear regularly" and has been relegated to "wear occasionally" status (aka conventions, etc.) I expected a little more quality for a [$]t-shirt.
Very happy with my tee. Thanks for making it available.
Awesome Shirt!!!
Awesome shirt
My husband is thrilled
Cool idea but cheap shirt
Shirt looks cool but feels somewhat scratchy/cheap
He saved every one of us!
This shirt elicits second looks and knowing smiles from a lot of people who obviously remember the film or love Queen.
Perfect for the true Flash Gordon fan!
My fianc'e and I gave this as a gift to his brother this year: Evidently he'd been wanting this EXACT shirt since he saw Flash wear it in the show. It was one of the later gifts he opened and became ecstatic at once (Which was out of character for him!) and put it on then and there. We were all very pleased with the gift, especially the receiver! This review includes his opinions.
my husband loved the shirt.
loved the shirt!!!
very good t shirt very good service
perfect !!
Flash Gordon Shirt
I tried to find this shirt for years. I usually wear an Xl, but should have bought an XXL. The shirt shrunk a lot after its first wash. Now it is pretty tight . . . just like Flash "Quarterback, New York Jets" wore it.
Utopian Tee.......
I loved the movie, kitschy as it sounds.....and am very happy to have a reminder of my childhood!!!
Colors Bleed :(
Really dissapointed, bought half a dozen items of here and this si the first one to fail! first wash the sleeves and collars bled all over it making the shirt unwearable. Buy as a costume and throw away rather than washing :(
Perfect replica
I bought this for last Halloween and it was pretty great. I washed it in cold water with whites and had no problem with the red color running. I did stain it up pretty good at a Halloween party (we won't go into my foolishness), but since I liked it so much, I bought a replacement for a Mardi Gras costume next year.
Great idea but poor quality.
Love the shirt, but on the first wash the red from the collar ran. The company's return policy says they're not responsible for any fading or bleeding. This tells me it must happen a lot!
Ming! Be afraid!
Cool product: it's exactly the same as the one in the movie! Great!
unique but too long.
Good enough for Freddie, good enough 4 U
High quality shirt that will withstand the ravages of Mongo.
great shirt everybody had a good laugh
bought shirt for a good laugh and it turned out perfect
Lettering faded quickly.. after 2 washes
Great T.... Lettering, but not the collar or sleeve ends faded after 2 washes.
This shirt saved everyone of us!
With this on I even smell like Sam Jones!
My Hero
I have always wanted this shirt since I was a kid and saw the movie. I met the real Flash @ Comic Con this year and he loved it. I told everyone where to find the shirt.
Red Ringer Flash Gordon t-shirt
nice shirt
Flash & Freddie
Perfect tee for a Queen concert!
Gordon's alive?!
I try to buy clothes (t-shirts mainly) that look good, are well recognized but unique and quirky. This t-shirt is genius and a convo starter. You gotta love Flash Gordon.
Don't wash this shirt
the red in the shirt bled over the entire shirt. Not only the first washing (cold water) but the second washing as well. My boyfriend gave up wearing it to avoid having to wash it.
Color Ran and ruined the shirt!
I bought this shirt for my husband and he totally loved it since he loves the Flash movie. When I washed it the first time in the washing machine, the red collar and sleeves ran after one washing. Since the white now has pink on it, the shirt is basically ruined since I can't bleach the shirt unless I spot bleach it. So, I bought another one because I felt bad for ruining the first one and carefully hand washed it this time. I layed it out to dry and it looked good at that point, but then it ran again during the drying process! I have two ruined Flash shirts and a very disappointed husband because he only got to wear them each once. Don't waste your money. Great shirt, but doesn't last after you wash it.
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text:
Looney Tunes: Back in Action Cheats & Codes
Check out our 1 cheat for Looney Tunes: Back in Action.
1 Cheats
Submit a Cheat.Submitted by:IGN_Cheats
On the code entry menu enter:
- DANGERD: Play the whole game as "Danger Duck".
- HENSAWAY: Attack with a new selectable weapon.
- PASSPORT: Access All Areas
- WEENY: Shrink Ray
- CANNON: Cannon Ball Costume
- OUTTAKE: Duck Danger Battle
- SUITSYOU: Free Costume Doors
- SLAPPY: Gives Slappy Fish to whack baddies.
- GOBBLE: Gossamer Doors Revealed
- TOUGHAGE: Invulnerability
- FURRYOUS: Wile E. Coyote Game
You must be Logged in to submit a cheat.
Game Details
Published by:
Electronic Arts, Warner Bros. Interactive
Developed by:
Release Date:
United States: November 20, 2003
E for Everyone
: Mature Sexual Themes
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Brings the GTA world to the early 90s in this huge California-based installment. Deal with rival gangs and corrupt cops as you climb the crime ladder.

subset: commoncrawl


text:
This bath creates a luxurious space for husband and wife. A freestanding quarter-sawn island centered in the room matches the quartered oak double doors and offers continuity moving into the room. Each spouse has his or her own space with two large, beaded inset, white painted vanities, double medicine cabinets and framed mirrors. The shower and toilet area were placed on a diagonal to soften the space. An antique-style freestanding tub with period faucets was nestled into a seven-window alcove for a lovely focal point. Subway tile wainscoting adds old world charm. Natural stone with a mosaic border on the floor accentuates the shape of the room. The result; an architecturally elegant bath is highlighted with broad casings, as well as crown and base moldings. Photo by Peter Rymwid.
A link to %this page% was e-mailed
Browse new bathrooms from top designers.


text:
The financial crisis that has engulfed the nation in recent months has spread to every sector of the New York economy, including Wall Street. While most taxpayers feel a strong disconnect between their everyday middle-class lives and investment honchos, in reality, problems on Wall Street present very real consequences on the rest of the state. Today, more than ever, the popular metaphor �when Wall Street sneezes, New York state gets the flu� is ever more apparent.
New York state receives about 20 percent of its tax revenues from Wall Street in the form of taxes on income, bonuses, capital gains and large real estate transactions. In fact, a recent report by the New York City Comptroller�s Office indicated that Wall Street incomes have more than doubled to an average of $387,000, demonstrating the sheer amount of taxable income available to the state.
Unfortunately, as recent financial news has indicated, Wall Street is no more immune from economic hardships than small businesses and middle-class taxpayers. Like in most sectors, economic downturn leads to job losses. However, Wall Street�s immense impact on the New York state budget has led to unforeseen impacts on middle-class taxpayers. The economic slowdown has led to a mortgage credit crisis and the collapse of Bear Stearns and with it, a larger than expected job loss. Economy.com expects 25,000 Wall Street jobs will be lost and the New York State Comptroller�s Office reported in January that average 2007 Wall Street bonuses have dropped 4.7 percent.
Wall Street�s troubles point to difficult times for New York state as we move forward. Unlike other sectors, when Wall Street suffers, our economy does not just slow down. Wall Street�s substantial effect on state finances has led to huge revenue gaps and historic budget deficits.
In recent years, spending has continued to rise. Comptroller Thomas Dinapoli projects that spending will rise 7.4% every year until 2011-12, while revenues are only projected to increase by an average of 4.7%. This is clearly unsustainable. We must act now to limit the impact of the substantial decline in tax revenue. While Governor Paterson has proposed $800 million in spending cuts, the reduction in government spending must not end there. It is vital that we continue to meet our commitment to taxpayers, but demonstrate the fiscal restraint necessary to ensure future economic prosperity and reduce the need to raise taxes. I urge my fellow legislators to do the same.
- How a Bill Becomes a Law
- Fitzpatrick Holds Press Conference To Introduce Comprehensive Mandate Relief Legislation
- Basic STAR Re-Registration Program For Homeowners Available From August 19 Through December 31
- McLaughlin & Fitzpatrick Call On Silver To Donate Frequent-Flier Miles Awarded At Taxpayer Expense
- Long Island Assemblymen Host Meeting Organizing Groups To Help Troubled Youth


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Fine dining menu includes seafood, beef, fowl and pork


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The process of buying a new Mazda car or truck can seem overwhelming if you don't know where to begin. Edmunds.com can get you started on the right track with a convenient directory of Mazda car dealerships in and around Bronx, New York. Compare online price quotes on the new or used car, truck, SUV, minivan, or wagon of your choice to locate the best deals. Edmunds.com makes it easy to find trusted Mazda car dealers in Bronx, saving car buyers time and money on what will be an important purchase.
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C2C Gallery and Gifts is located in downtown Grand Haven.
C2C offers beautiful, one-of-a-kind handcrafted artwork. C2C is committed to the promotion of Michigan artisans and other nationally recognized artists; offering high-quality, attainable Fine Arts for your every day life.
Online Shopping!
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Come visit us and see why we say, C2C…Art For Your Every Day Life.


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ESPN.com: NCF On The Trail | [Print without images] |
Ultra-athletic defensive end Lorenzo Carter, ranked No. 14 in the ESPN 150, would address an important need for FSU. |
Although big middle linebacker Kain Daub is committed to Florida State, the Noles know they will have to fend off plenty of suitors. |


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ISI B25300 Customer Reviews
1 Customer Reviews
Product Code: 061-B25300
Product Code: 061-B25300
Comments about ISI Measuring Cup Set w/ 4-Cup, 2-Cup & 1-Cup Capacity, Curved Lip:
I have bought and given several as this is my favorite new kitchen accessory. The silicone construction allows for the cup to be compressed for easy pour and the nesting of the set saves cabinet space. I thew away all of my old measuring cups!


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Months before my husband and I decided to walk away, I spoke with someone at Bank of America regarding HAMP. At the time, we were actually trying to do a refi with HARP, but it turned out our LTV ratio was terrible, so we didn't qualify (this was actually our final attempt to "save" our house before we decided that it just wasn't worth it). In any case, we ran some numbers on the phone and realized our incomes were too high to qualify.
Fast forward to now. We haven't paid our mortgages for two months. I haven't answered any phone calls or letters, and I have made no attempt to contact the bank. We did, however, recently receive a HAMP application via Fed Ex.
I've been told that we should go ahead and fill it out. My issue is that I feel like we've already provided them all the info. (Un)fortunately, we don't have any real hardship - we have simply decided that it makes absolutely no financial sense to keep our place. Is it OK to fill out the forms again and have them go through the motions of possibly ordering past tax returns, pulling credit scores, etc?
For those who are aware that they will "not qualify", have you filled out the entire form honestly, or have you just left out pertinent info? Or, should I not even bother with trying as in the end, it doesn't really make a difference?
Any input would be most appreciated. Thanks!


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My ultimate pet-peev is when people criticise snipers for camping. It's what snipers do for f%^s sake. If you don't run around in the open for long periods of time you should have nothing to worry about.
Before all of you are born Snipers are already made to camp and wait. It is because Sniper guns do not fire like sub-machine guns. A sniper charging in the front lines are total ldlots.
@yeah_28 most snipers are campers. I dont think they are idiots to run to the frontlines and get shot. So yeah they are campers
Battlefield 3 most likely will not be seen on the pro circut. If that's why you're playing it, you are wasting time.
Being a Pro doesn't mean that they are Experts...... Well.... the tips she gave will be useful for noobs.... But any ways thanks for the tips. ;)
Dear Tom Magrino, you sir are an noob for saying that an US Weapon in an AK47. And I can't belive that you work at GAMESPOT (an gaming news site). An grandpa(that have not made contact wh.. any games) now's how an Russian weapon looks like when is futures in lots of war films and the planet is full of AK the best assault rifle compared to an US gun. If you ar an american you must kill your self whit that AK ops I mean M4. Just messing around. But seriously you suck at interviewing(in gaming I mean, but you ar a good interviewer). you mist your calling. I will let you decid what your calling is. P.S. Sorry for my spelling, I usually don't spell in an other language. Taking you for reading this rage comment. Have a nice day. (FPS RUSSIA) quote...
excuse me but a sniper doesnt mean a camper, just to clear that out, also, campers are one of the most innofensive players you can meet, so no problem at all.
I have not yet, but seems to be an excellent game that reinforces the fps genre, I'll wait to see the calificaion of cod modern warfare 3, and that would help me decide, but I think both should be a cheer
@endorbr society has deemed that skill alone doesnt matter. take a look at the quota for womens in everything.
@grey_fox1984 - Gorgeous is a subjective word. And I'm not ragging her for getting paid to play games, I'm ragging Gamespot for using her as an expert. The only reason she is getting recognition is because she is female. Having seen her play multiple times now her skill isn't up to what I would label expert. She is no slouch but I play just as well or better than she does. She just seems to think she deserves extra recognition because she happens to be a woman, as though that really matters to the game.
@demonrahl9183 Your just pissed that she could woop your ass. They were tips for beginners and noobs, not pro's like you obviously thing you are. Show some respect.
@Hornysmurf a HOT girl and to be fair, they call her a "pro" in the vid, never a "champion" - there is a clear distinction. And in all honesty, I respect a girl who uses her looks and moderate talent to become a pro gamer way more than all the hot girls with NO talent who become auto-tuned singers these days. Even in this vid, she does pretty well while talking and giving commentary and her tips are sound, even if they won't revolutionize your game.
@demonrahl9183 Dude were you even watching the video? Basic tips for beginners is what she was giving out. If you think watching these video's will make you a better player then forget it, go play, kill kill kill...
shes an idiot. almost every tip she had was pointless. shes a disgrace to gamers.
She hasn't done anything in the MLG community. She's just sponsored. She has never placed good at any mlg event either. She's just known because she's a girl. Trust me I know her from GOW3
@endorbr dude, are you seriously ragging on a gorgeous girl who gets paid to play first person shooters?
Somebody wanna tell me why they keep using Mrs. Violence as an expert? Just because you call yourself a pro and make money playing video games doesn't make you an expert. Plenty of people make money doing things they are only half-a$$ passable at in life.
I should have watched this video before i hit level 9, never mind, thanks for the tips anyways.
So basically the people who BF3 are not pros according to gamespot associate. What a disgrace to PC community.
Pro Gamer? Absolutely you are my dear. Oh hey big news for me too, I was just named as an alternate pilot for the Space Shuttle. I know right?! It's crazy, we're both doing so well.
now now, how many of you guys would have been killed by that tank almost instantly lol! her advice was clearly for people who have not played fps before and she clearly just got the game herself. i have to agree that her bangs were all kinda messed up though lol! she blasted every dude she came across though! while talking. as for true tips, ugh aim at the chest and pray for a headshot? sorry lil miss that's not battlefield!
anyone else notice how many times that dude said "that makes sense"? that kinda drove me insane. lmao.
I like snipers, they dont go running away when you try stab em. It's all about the dog tags
@Overlord93 In fact, it isn't; also, I was talking about the definition. I thought definitions and concepts were "things"? As in "abstract things"? With an onthological connotation inside of the language? In every other language I know they are and I'm pretty sure english is no exception. However, it's true I omited a word in there, the article "a" before "part of it".
@lobbypolice I have to agree. Playing shooters on a console and calling it pro-gaming is a joke at best. Being best in a console fps game is like winning the Special Olympics. Yeah you won but deep inside you know there's something more competitive and better out there.
She called herself pro gamer,holy **** i don't think so,go learn what name of the weapon.
@Overlord93 That's only part of it, in case you didn't know. I'll give you a clue: "profess" -sion.


text: Big Lottery WinnersThe odds of being a big lottery winner is high, 13,983,816 to 1 in a typical 6/49 lotto game, to be exact. Let's say you buy one lottery ticket per week. 13,983,816 weeks is roughly 269,000 years. In the quarter-million years of play, you could expect to win the jackpot only once. However, this should not discourage lotto fans from enjoying the game. Many have in fact become millionaires by playing the lottery. The following table shows the biggest lottery winners to date.


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OneConnection.com develops quality web sites and software to assist your business in reaching its objectives. We implement both internal business solutions to streamline your processes and external Internet solutions that engage your customers.


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T-Mobile Broadband Prepaid
I have T-Mobile for my cell phone and am on prepaid service, the kind where I buy a card and refill it. Every once in a while, I'll need the internet for something and would like the option to use it, but don't know of a way I can. I don't want to pay big bucks for internet because I rarely use it and T-Mobile is 2G where I live. Is there some way can do this? Thanks for any help.
We all find out who we are when nobody's looking.
$2 pay by the day plan sounds like it would work for you.http://prepaid-phones.t-mobile.co...hon
You can switch between this and your pay as you go plan, at any time, online on your T-Mobile account, or through the automated system at 611 I think. Simply switch to it for the days you need it, switch back to pay as you go before midnight that day to not incur the charge the next day. |
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text:
Definition of systems analyst in English:
systems analyst
Line breaks: sys¦tems ana|lystnoun
- A person who analyses a complex process or operation in order to improve its efficiency, especially by applying a computer system.More example sentences
- Professionals such as systems analysts, computer scientists, engineers, programmers, eCommerce developers and Web designers are in great demand.
- This still leaves teachers $3,000 per year short of accountants, $17,000 short of computer systems analysts, and $25,000 short of engineers.
- We'll need double today's number of computer engineers, systems analysts and computer support specialists.
systems analysis
- More example sentences
- Within three years I was able to go from 'project librarian' directly into development work in applications programming, then into systems analysis and programming.
- Formal approaches to computer design such as structured systems analysis and design, for example, require considerable investment of time in the design and implementation of interview or questionnaire protocols.
- In consulting on a library automation system, I even heard a definition of information architecture that was coextensive with the field of systems analysis.


text:
Investigations into the cytotoxic effects of Bangladeshi medicinal plants
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Title | Investigations into the cytotoxic effects of Bangladeshi medicinal plants |
Author | Grice, Darren; Tiralongo, Evelin |
Publication Title | 7th Joint Meeting of AFERP, ASP, GA, PSE & SIF – Natural Products with Pharmaceutical, Nutraceutical, Cosmetic and Agrochemical Interest |
Editor | Thieme |
Year Published | 2008 |
Publisher | Planta medica |
Peer Reviewed | No |
Published | Yes |
Publication Type | Conference Publications (Extract Paper) |
Please use this identifier to cite this record: http://hdl.handle.net/10072/38801
Griffith University copyright notice
Copyright in individual works within the repository belongs to their authors or publishers. You may make a print or digital copy of a work for your personal non-commercial use. All other rights are reserved, except for fair dealings or other user rights granted by the copyright laws of your country.


text:
Definition of kiln-dry in English:
Syllabification: kiln-dryverb
- Dry (a material such as wood or sand) in a kiln.More example sentences
- The decline will end when manufacturers understand international standards, start to use properly kiln-dried wood and make furniture with a floating construction.
- World-soaked preachers and churches must be kiln-dried before they are fit for revival kindling wood.
- All timber used is kiln-dried and pressure-impregnated to withstand the harsh desert climate and is from renewable sources.


text:
Massey, Elizabeth and Lowell, James and Hunter, Andrew and Steele, David (2009) Lesion boundary segmentation using level set methods. In: VisApp - Proceedings of the Fourth International Conference on Computer Vision Theory and Applications - Volume 1, February 5-8, 2009, Lisbon, Portugal.
Item Type: | Conference or Workshop Item (Paper) |
PDF (Requires Adobe Acrobat Reader)
LBFitLS-VisApp09.pdf Download (246Kb) |
Official URL: | http://www.pubzone.org/dblp/conf/visapp/MasseyLHS0... |
Divisions: | College of Science > School of Computer Science |
Abstract: | This paper addresses the issue of accurate lesion segmentation in retinal imagery, using level set methods and a novel stopping mechanism - an elementary features scheme. Specifically, the curve propagation is guided by a gradient map built using a combination of histogram equalization and robust statistics. The stopping mechanism uses elementary features gathered as the curve deforms over time, and then using a lesionness measure, defined herein, 'looks back in time' to find the point at which the curve best fits the real object. We implement the level set using a fast upwind scheme and compare the proposed method against five other segmentation algorithms performed on 50 randomly selected images of exudates with a database of clinician marked-up boundaries as ground truth. |
Date Deposited: | 15 Oct 2008 18:00 |
URI: | http://eprints.lincoln.ac.uk/id/eprint/1658 |
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Rick Victor
Real Name
Eric Thompson
Date of Birth
December 4, 1980
Place of Birth
Despite being sent legal threats from the company, it appears that Sin Cara has opted to be defiant towards WWE. The masked wrestler recently won a championship down in Mexico while using the name and character, both of which he claims ownership to. New merchandise has been made despite the possibility of a lawsuit coming.
March 5, 2014
While he has stepped away from the spotlight quite a bit, the civil lawsuit between TNA and Scott Steiner is still an ongoing thing. A judge in Nashville has decided to postpone things from March until November. For those wondering, that is the reason why Steiner has been rather quiet online for the past year. He wants to avoid any further trouble.
March 2, 2014
Hunico might be cashing in a nice pay per view bonus check at Wrestlemania 30 this year, as WWE still has interest in using the Sin Cara character at the event. Merchandise sales have remained strong, and the company wants to continue to capitalize. There may be a lawsuit coming from the original performer, though.
February 12, 2014
The Minnesota Twins of the Major Baseball League has filed paperwork to oppose the WWE's attempt to obtain a trademark for the Bella Twins.
November 20, 2013
Since management wanted to test out the developmental wrestlers to see if they were ready to be called up to the main roster, the Ascension, a tag team consisting of Conor OBrian and Rick Victor, were given a match against Diego and Fernando at the big live event in New York City this weekend. WWE even paired Vickie Guerrero up with them. Unfortunately, though, the crowd was silent and indifferent towards the duo, thus hurting their chances of being promoted.
March 9, 2014
Cody Rhodes and Goldust paid a visit to WWE NXT, and the brother tandem were placed into a match against Rick Victor and Conor OBrian. The match ended in a disqualification, and the developmental wrestlers were on the losing end.
January 30, 2014


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Cancer Cell, Volume 22, Issue 5, 13 November 2012, Pages 565-566
Barbara Chaneton and Eyal Gottlieb
SummaryTherapeutic strategies that target glycolysis and biosynthetic pathways in cancer cells are currently the main focus of research in the field of cancer metabolism. In this issue of Cancer Cell, Hitosugi and colleagues show that targeting PGAM1 could be a way of "killing two birds with one stone".
Summary | Full Text | PDF (189 kb) - Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis
Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis
Cell, Volume 152, Issue 3, 31 January 2013, Pages 599-611
Li Ma, Yongzhen Tao, Angeles Duran, Victoria Llado, Anita Galvez, Jennifer F. Barger, Elias A. Castilla, Jing Chen, Tomoko Yajima, Aleksey Porollo, Mario Medvedovic, Laurence M. Brill, David R. Plas, Stefan J. Riedl, Michael Leitges, Maria T. Diaz-Meco, Adam D. Richardson and Jorge Moscat
SummaryTumor cells have high-energetic and anabolic needs and are known to adapt their metabolism to be able to survive and keep proliferating under conditions of nutrient stress. We show that PKCζ deficiency promotes the plasticity necessary for cancer cells to reprogram their metabolism to utilize glutamine through the serine biosynthetic pathway in the absence of glucose. PKCζ represses the expression of two key enzymes of the pathway, PHGDH and PSAT1, and phosphorylates PHGDH at key residues to inhibit its enzymatic activity. Interestingly, the loss of PKCζ in mice results in enhanced intestinal tumorigenesis and increased levels of these two metabolic enzymes, whereas patients with low levels of PKCζ have a poor prognosis. Furthermore, PKCζ and caspase-3 activities are correlated with PHGDH levels in human intestinal tumors. Taken together, this demonstrates that PKCζ is a critical metabolic tumor suppressor in mouse and human cancer.
Summary | Full Text | PDF (2643 kb) - Molecular Characterization of 3-Phosphoglycerate Dehydrogenase Deficiency—a Neurometabolic Disorder ...
Molecular Characterization of 3-Phosphoglycerate Dehydrogenase Deficiency—a Neurometabolic Disorder Associated with Reduced L-Serine Biosynthesis
The American Journal of Human Genetics, Volume 67, Issue 6, 1 December 2000, Pages 1389-1399
Leo W.J. Klomp, Tom J. de Koning, Helga E.M. Malingré, Ellen A.C.M. van Beurden, Miny Brink, Frans L. Opdam, Marinus Duran, Jaak Jaeken, Merce Pineda, Lionel van Maldergem, Bwee Tien Poll-The, Inge E.T. van den Berg and Ruud Berger
Abstract3-phosphoglycerate dehydrogenase (PHGDH) deficiency is a disorder of L-serine biosynthesis that is characterized by congenital microcephaly, psychomotor retardation, and seizures. To investigate the molecular basis for this disorder, the PHGDH mRNA sequence was characterized, and six patients from four families were analyzed for sequence variations. Five patients from three different families were homozygous for a single nucleotide substitution predicted to change valine at position 490 to methionine. The sixth patient was homozygous for a valine to methionine substitution at position 425; both mutations are located in the carboxyterminal part of PHGDH. In vitro expression of these mutant proteins resulted in significant reduction of PHGDH enzyme activities. RNA-blot analysis indicated abundant expression of PHGDH in adult and fetal brain tissue. Taken together with the severe neurological impairment in our patients, the data presented in this paper suggest an important role for PHGDH activity and L-serine biosynthesis in the metabolism, development, and function of the central nervous system.
Abstract | Full Text | PDF (1403 kb) - …more
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Copyright © 2012 Elsevier Inc. All rights reserved.
Cancer Cell, Volume 22, Issue 5, 585-600, 13 November 2012
Add/View Comments (0)Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth
Taro Hitosugi1, 12, Lu Zhou4, 11, 12, Shannon Elf1, Jun Fan1, Hee-Bum Kang1, Jae Ho Seo1, Changliang Shan1, Qing Dai4, Liang Zhang4, Jianxin Xie5, Ting-Lei Gu5, Peng Jin2, Masa Alečković6, Gary LeRoy6, Yibin Kang6, Jessica A. Sudderth7, Ralph J. DeBerardinis7, Chi-Hao Luan8, Georgia Z. Chen1, Susan Muller3, Dong M. Shin1, Taofeek K. Owonikoko1, Sagar Lonial1, Martha L. Arellano1, Hanna J. Khoury1, Fadlo R. Khuri1, Benjamin H. Lee9, Keqiang Ye3, Titus J. Boggon10, Sumin Kang1, Chuan He4, , and Jing Chen1, ,
1 Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
2 Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
3 Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
4 Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA
5 Cell Signaling Technology, Inc. (CST), Danvers, MA 01923, USA
6 Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
7 UT Southwestern Medical Center, Dallas, TX 75390, USA
8 Department of Molecular BioSciences, Northwestern University, Evanston, IL 60208, USA
9 Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
10 Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
Corresponding author
11 Current address: School of Pharmacy, Fudan University, Shanghai 201203, China
12 These authors contributed equally to this work
► PGAM1 controls 3-PG and 2-PG levels to coordinate glycolysis and biosynthesis ► 3-PG binds to and inhibits 6PGD in the oxidative PPP ► 2-PG potentiates PHGDH to provide feedback control of 3-PG levels ► PGAM1 is a promising anticancer target
- It is unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly growing tumors. We found that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1), commonly upregulated in human cancers due to loss of TP53, contributes to biosynthesis regulation in part by controlling intracellular levels of its substrate, 3-phosphoglycerate (3-PG), and product, 2-phosphoglycerate (2-PG). 3-PG binds to and inhibits 6-phosphogluconate dehydrogenase in the oxidative pentose phosphate pathway (PPP), while 2-PG activates 3-phosphoglycerate dehydrogenase to provide feedback control of 3-PG levels. Inhibition of PGAM1 by shRNA or a small molecule inhibitor PGMI-004A results in increased 3-PG and decreased 2-PG levels in cancer cells, leading to significantly decreased glycolysis, PPP flux and biosynthesis, as well as attenuated cell proliferation and tumor growth.


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Notes from the National Training Center - Jan. 16, 2004
Jan. 16, 2004
CARSON, Calif. (January 16, 2004) - With nine national teams holding training camps this January at U.S. Soccer's National Training Center at The Home Depot Center in Carson, Calif., ussoccer.com will be providing you with updates on the progress of each team's camp with "Notes from the National Training Center." The NTC is still bustling as the Men's National Team, Women's National Team and the Under-23 MNT continue their training camps. Read on for today's notes.


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Each player as a leader of a major country, competes to develop his country faster than those of his neighbors. But rapid production causes pollution. During the course of play, it is apparent that each country's pollution affects the global pollution levels, and at the same time global pollution has an influence on local pollution levels. A central organization -- the United Nations -- serves as a political forum where each developing country can play power politics.


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Just want digital backgrounds without the templates and other files included in other packages? No problem! Take a look here! Whether you need more backdrops for background replacement, such as with green screen, or you want more backgrounds for your Photobacks templates, these options will do the trick! Note: only the Advantage Package and Upgraded Advantage Package will include some backdrops below.
The following digital backdrops series are included in the packages above and in other packages as noted, however they are sold separately for those who do not need everything included in the larger packages. At this time, these are the only digital backdrops series sold separately, outside of packages.
Take a look at our Photobacks Packages as they include unique volumes of digital backdrops not sold here! Note, the only Photobacks Packages that do include some of the volumes sold above are the Advantage Package and Upgraded Advantage Package. All of the other Photobacks Packages have unique volumes of digital backgrounds, not sold separately.


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Kenneth Cole Wool Coats
Buy kenneth cole mens pea coat with bib or kenneth cole mens herringbone walker coat offers at everday low prices.
The 'Melton' double-breasted peacoat from Kenneth Cole Reaction is a cold-weather essential. The coat is a wool blend to ensure that you always stay warm in any weather. The coat features two front slant pockets and two interior pockets so you always have somewhere to put your important personal items.
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Kenneth Cole Men's Herringbone Field Coat
Plush wool carcoat with knit bib.


text: The corner of the sign caught my eye, "YARD SALE" was all it read. My car was trained on what to do, As it turned it jerked my head. As I rounded the corner of that busy street, I could not believe my eyes. This was the biggest yard sale I had ever seen. It stretched as far as the big, blue sky. There were clothes, what-nots, toys and curtains, An umbrella and even a car! My mind was lost in the moment. Then I spotted that simple, little jar. The sign read "DONATIONS PLEASE", And a picture of a child was there. She had the most beautiful, big blue eyes; But sadly she had no hair. My heart knew what I needed to do, Though little money I had. I really wanted that umbrella there; But her eyes looked oh so sad. So, I emptied my change into that jar, And peace flowed over me. God turned my life around that day; Through a "YARD SALE", He made me see.


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This set include a lot of old photos of Young Thai Girls.
Some of them were taken from the 1930's at the time when the Kingdom was called Siam.
Fashionable Ladies from Bangkok, Thailand, 1948
Songkran Girls in Chiang Mai, Thailand, 1937
Songkran is the traditionnal New Year Day in Thailand. It is a very festive time when people are splashing each other in the street with water.
Miss Lampang, 1934
Miss Siam, 1934
Siamese Girl, 1935
Sumitra Kanchana, Miss Chiang Mai, 1949
If you're wondering, the beautiful Sumitra Kanchana, Miss Chiang Mai 1949, is on the front left of the picture
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Sanuk: Gettin' to know Jeremy Jones - Snow Team
A Snowboarding video by Sanuk - 696 views
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Get to know Sanuk snow icon Jeremy Jones as he sheds light on the joys of big mountain free-riding, starting Jones Snowboards and the importance of protecting Winter as we know it. Smile...pass it on!
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Has anyone found a good EASY to use application that will enable the iPad to print to a home printer?
This is a discussion on Printing within the iPad General Discussions forums, part of the Apple iPad Discussions category; Has anyone found a good EASY to use application that will enable the iPad to print to a home printer?...
Has anyone found a good EASY to use application that will enable the iPad to print to a home printer?
Most likely written on my iPad
Try: WePrint Server....Available At Itunes Store.....
I like air sharing HD....but I haven't used anything else
Try the EuroSmartz page. They make a slew of printing apps. Choice is yours.
Not white, not black just passionate shades of grey...
Yuno Wataï Minh
The reported best, and what I am going with is Fax, Print, and Share for iPad. Its $5.99.
Yes - somehow.
It supports wireless/network printers.
But it is an awkward process.
First you pick the file you want to print, send it by email to your email account.
Then you tell Fax, Print and Share to fetch that email and download the attached document/file into the app. Once you have the document (pdf, numbers, pages, etc.) in the app, you can print it without a host computer.
This is how the developer surrounds the lack of printing integration by Apple.
Most likely written on my iPad
"The reported best"? With 41 ratings with an average of 1 star? Really?
Eurosmartz WePrint server using Print Central.
Believe me, until direct printing is supported, which is unlikely with the large driver files needed to interface with most printers.
The plain and simple of it is that most printers could use what is called a generic Post Script driver. However, every one and their uncle will complain because basic printing won't be enough for them.
"Why won't it scan from my document feeder, I printed from e-mail within the printer and my iPad won't recognize it's file format, my printer is saying incorrect paper size, I'm getting a 50.4 error saying uncompleted data, blah blah blah"
That's all you would hear from many users if generic post script was the only option. To this day, many people install a full DVD suite of software to control one printer. When all that is really needed is a simple generic driver. For most that are tech savvy this would be ok, but you have many more that would assume all those other features should be supported.
HP has an app that prints photos or images directly to HP networked printers, but that leaves out the other 80% of apps or documents that also need support.
Your better off for now sticking with one of the print suite apps like Print Central, that support many doc types, not the other way around, an OS that hardly supports one printer.


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Motor-Substrate Interactions in Mycoplasma Motility Explains Non-Arrhenius Temperature Dependence Biophysical Journal, Volume 97, Issue 11, 2 December 2009, Pages 2930-2938 Jing Chen, John Neu, Makoto Miyata and George Oster Abstract Mycoplasmas exhibit a novel, substrate-dependent gliding motility that is driven by ∼400 "leg" proteins. The legs interact with the substrate and transmit the forces generated by an assembly of ATPase motors. The velocity of the cell increases linearly by nearly 10-fold over a narrow temperature range of 10–40°C. This corresponds to an Arrhenius factor that decreases from ∼45 kBT at 10°C to ∼10 kBT at 40°C. On the other hand, load-velocity curves at different temperatures extrapolate to nearly the same stall force, suggesting a temperature-insensitive force-generation mechanism near stall. In this article, we propose a leg-substrate interaction mechanism that explains the intriguing temperature sensitivity of this motility. The large Arrhenius factor at low temperature comes about from the addition of many smaller energy barriers arising from many substrate-binding sites at the distal end of the leg protein. The Arrhenius dependence attenuates at high temperature due to two factors: 1), the reduced effective multiplicity of energy barriers intrinsic to the multiple-site binding mechanism; and 2), the temperature-sensitive weakly facilitated leg release that curtails the power stroke. The model suggests an explanation for the similar steep, sub-Arrhenius temperature-velocity curves observed in many molecular motors, such as kinesin and myosin, wherein the temperature behavior is dominated not by the catalytic biochemistry, but by the motor-substrate interaction. Abstract | Full Text | PDF (514 kb) |
Mechanism of Tension Generation in Muscle: An Analysis of the Forward and Reverse Rate Constants Biophysical Journal, Volume 92, Issue 8, 15 April 2007, Pages 2865-2874 Julien S. Davis and Neal D. Epstein Abstract Tension generation in muscle occurs during the attached phase of the ATP-powered cyclic interaction of myosin heads with thin filaments. The transient nature of tension-generating intermediates and the complexity of the mechanochemical cross-bridge cycle have impeded a quantitative description of tension generation. Recent experiments performed under special conditions yielded a sigmoidal dependence of fiber tension on temperature—a unique case that simplifies the system to a two-state transition. We have applied this two-state analysis to kinetic data obtained from biexponential laser temperature-jump tension transients. Here we present the forward and reverse rate constants for de novo tension generation derived from analysis of the kinetics of the fast laser temperature-jump phase τ2 (equivalent of the length-jump phase 2slow). The slow phase τ3 is temperature-independent indicating coupling to rather than a direct role in, de novo tension generation. Increasing temperature accelerates the forward, and slows the reverse, rate constant for the creation of the tension-generating state. Arrhenius behavior of the forward and anti-Arrhenius behavior of the reverse rate constant is a kinetic signature of multistate multipathway protein-folding reactions. We conclude that locally unfolded tertiary and/or secondary structure of the actomyosin cross-bridge mediates the power stroke. Abstract | Full Text | PDF (289 kb) |
Thermodynamic View of Activation Energies of Proton Transfer in Various Gramicidin A Channels Biophysical Journal, Volume 82, Issue 1, 1 January 2002, Pages 182-192 Anatoly Chernyshev and Samuel Cukierman Abstract The temperature dependencies (range: 5–45°C) of single-channel proton conductances (gH) in native gramicidin A (gA) and in two diastereoisomers (SS and RR) of the dioxolane-linked gA channels were measured in glycerylmonooleate/decane (GMO) and diphytanoylphosphatidylcholine/decane (DiPhPC) bilayers. Linear Arrhenius plots (ln (gH) versus K−1) were obtained for the native gA and RR channels in both types of bilayers, and for the SS channel in GMO bilayers only. The Arrhenius plot for proton transfer in the SS channel in DiPhPC bilayers had a break in linearity around 20°C. This break seems to occur only when protons are the permeating cations in the SS channel. The activation energies (Ea) for proton transfer in various gA channels (∼15kJ/mol) are consistent with the rate-limiting step being in the channel and/or at the membrane-channel/solution interface, and not in bulk solution. Ea values for proton transfer in gA channels are considerably smaller than for the permeation of nonproton currents in gA as well as in various other ion channels. The Ea values for proton transfer in native gA channels are nearly the same in both GMO and DiPhPC bilayers. In contrast, for the dioxolane linked gA dimers, Ea values were strongly modulated by the lipid environment. The Gibbs activation free energies (ΔGo#) for protons in various gA channels are within the range of 27–29kJ/mol in GMO bilayers and of 20–22kJ/mol in DiPhPC bilayers. The largest difference between ΔGo# for proton currents occurs between native gA (or SS channels) and the RR channel. In general, the activation entropy (ΔSo#) is mostly responsible for the differences between gH values in various gA channels, and also in distinct bilayers. However, significant differences between the activation enthalpies (ΔHo#) for proton transfer in the SS and RR channels occur in distinct membranes. Abstract | Full Text | PDF (314 kb) |
Copyright © 1979 The Biophysical Society All rights reserved.
Biophysical Journal, Volume 25, Issue 3, 389-406, 1 March 1979
Research Article
J.L. Pirkle, D.L. Ashley and J.H. Goldstein
A simple, precise, and rapid pulse nuclear magnetic resonance technique for measuring the rate of water exchange across the erythrocyte membrane is presented. The technique is based upon the nonlinear fit of Carr-Purcell-Meiboom-Gill (CPMG) transverse relaxation time data of blood doped with 1.7 mM MnCl2 to the general two-compartment exchange condition. Previous approaches using CPMG data required high MnCl2 concentrations (25–53 nM), shown in this work to induce systematic errors ranging from 35 to 45%. At 23 degrees C the average residence time of a water molecule inside the erythrocyte (tau a) is 21.0 +/- 0.6 ms (SE). The Arrhenius plot for water exchange is linear over the range of 3 degrees - 37 degrees C and th Arrhenius activation energy is 4.79 +/- 0.03 kcal (SE). This value does not differ significantly from the energy required for bulk water flow. Results are compared with previous determinations, and sources of systematic error in tau a and the activation energy are evaluated.


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January 14, 2013
The Chicago Transit Authority's (CTA) board unanimously approved the purchase of at least 300 new buses as part of CTA's bus fleet modernization initiative announced by Mayor Rahm Emanuel and CTA President Forrest Claypool in June 2012.
The board approved a contract with Nova Bus that allows for the purchase of at least 300 buses and as many as 450 clean diesel buses that will provide customers with a more comfortable and reliable ride.
With a standard useful life of 12 years, the 484 6400-series Nova buses that were purchased by CTA between 2000-2002 will be gradually replaced with the new, standard 40-foot, low-floor, clean diesel buses following delivery of a prototype in December with full-production expected to begin in February 2014.
The new 37-seat buses will feature fare collection equipment for CTA's new Ventra fare payment system (to launch this summer), LED lighting, multiple security cameras and improved fuel economy. The buses will be in compliance with the latest EPA emissions standards and will meet and exceed all current ADA requirements, including two mobility device securement locations and an all-electric ramp with a decreased slope when deployed for easier access.
The contract was awarded to Nova Bus following a competitive bid process. According to the terms of agreement, CTA will purchase a minimum of 300 buses at an amount not to exceed $148 million, with an option to purchase up to 150 additional buses following Board approval. Funding for the purchase is a combination of mostly federal formula funds and CTA bond proceeds.
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Sources: Brett Favre apologizes
Vikings quarterback Brett Favre apologized to his teammates for being a distraction during a meeting Monday morning and told them he is prepared to play "lights out tonight" when Minnesota faces the New York Jets, sources told ESPN senior NFL analyst Chris Mortensen.
Vikings kicker Ryan Longwell, who was also Favre's teammate in Green Bay, told ESPN's Michele Tafoya it was very similar to the emotion Favre showed in December 2003 when he led the Packers to victory in a Monday night game the day after his father died.
After the Vikings' 29-20 loss to the Jets, Favre acknowledged he spoke with his teammates but didn't get into details.
"That's between me and my teammates, apparently not all of them," he told reporters.
The NFL is aggressively investigating allegations that Favre sent inappropriate messages and photos to a former Jets employee, a source familiar with the league's review told Mortensen.
NFC North blog
ESPN.com's Kevin Seifert writes about all things NFC North in his division blog.
NFL security was at the Jets' facility Monday to interview a handful of employees, including members of the media relations department, two sources told Mortensen.
The investigation is on a fast track and commenced Thursday, the same day that Deadspin.com posted voice messages and salacious photos that Favre allegedly sent to Jenn Sterger when both were employed by the New York Jets in 2008.
On Tuesday, Sterger's manager, Phil Reese, released the following statement from Sterger: "This is something that allegedly happened two years ago. We don't want a quick resolution, but the proper resolution."
On Monday, Reese declined to say if his client is cooperating with the NFL or has retained a lawyer, but issued a statement saying that "we're looking at all our options right now and our only concern is what's in Jenn's best interest."
Reese has said his client "did not provide Deadspin with any information." And a Deadspin editor said it paid a third party for the material and acknowledged it's possible the man who sent the voice mails and photos may not be Favre.
A source told Mortensen that the NFL also wants to interview one and possibly both massage therapists who also were reportedly sent inappropriate text messages by Favre. One of the therapists, who is contracted by the team, told Deadspin.com about the texts.
NFL security officials will meet with Favre if they are provided evidence that the allegations have merit, a source told Mortensen.
When asked by ESPN at a "Monday Night Football" production meeting, Favre would not directly comment on the allegations but said neither he nor his agent had been contacted by the NFL about the matter.
"My main focus is the New York Jets, they are a tough team; as good as they are that has been my focus," Favre told ESPN. "I hate in any way if this has been a distraction as I said Thursday -- we are here focused on trying to beat the Jets."
When asked about the accuracy of the reports, Favre told ESPN, "That will take its course."
Favre added that he would have "no problem with talking to the commissioner" if he is asked.
NFL commissioner Roger Goodell confirmed that the league is looking into the allegations.
"We are going through that and we are making sure we understand all the facts," Goodell said at halftime of Sunday's Chargers-Raiders game.
Goodell added once the investigation is complete, "we'll make a determination from there."
Information from ESPN senior NFL analyst Chris Mortensen and The Associated Press was used in this report.
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I'm in trouble, right?
"Knowing is half the battle" Expecting progress not perfection
Beside, LTHM, we Lawn Guylanders consider where you live to be the Midwest
Our neighbors had an outdoor Halloween party last night
The people you do your life with shape the life you live
I'm sitting here in sweatpants, thermal shirt under another thermal shirt with sleeves that come over my hands (the kind with the thumbhole) under a down vest, and socks of course.
Technically it's not winter yet .
So, to answer the question of the original poster...yes, you are in trouble!
"That's the thing about pain, it demands to be felt."
Pretty pretty please, don't you ever ever feel Like you're less than, less than perfect
I probably would have died. It was in the high 30s and started sleeting and snowing before the evening ended. I'm going to have to think these activities through in the future.
For last year's words belong to last year's language And next year's words await another voice. And to make an end is to make a beginning. - T.S. Eliot
50 Fahrenheit (10 C) New Yorkers try to turn on the heat. Canadians plant gardens.
40 Fahrenheit (4.4 C) Californians shiver uncontrollably Canadians Sunbathe.
35 Fahrenheit (1.6 C) Italian Cars won't start Canadians drive with the windows down
32 Fahrenheit (0 C) Distilled water freezes Canadian water gets thicker.
0 Fahrenheit (-17.9 C) New York City landlords finally turn on the heat. Canadians have the last BBQ of the season.
-40 Fahrenheit (-40 C) Hollywood disintegrates. Canadians rent some videos.
-60 Fahrenheit (-51 C) Mt. St. Helen's freezes. Canadian Girl Guides sell cookies door-to-door.
-100 Fahrenheit (-73 C) Santa Claus abandons the North Pole Canadians pull down their earflaps.
-173 Fahrenheit (-114 C) Ethyl alcohol freezes. Canadians get frustrated when they can't thaw the keg.
-459.4 Fahrenheit (-273 C) Absolute zero; all atomic motion stops. Canadians start saying "cold, eh? "
-500 Fahrenheit (-295 C) Hell freezes over. The Toronto Maple Leafs win the Stanley Cup
Sazzie... It was in the low 60's here this morning... Too cold to mow the lawn.
Yes, we're still mowing lawns down here.
See, we're still mowing here!!!
Canadians get frustrated when they can't thaw the keg.
Both had DDays and TT Separated.
Do not let others be your reference for who you see in the mirror.
Stop allowing people to hurt you, because you don't love you enough to walk away.
Yep, Sad, you're in trouble. You've lost your edge in AZ and TX!
"I could have missed the pain, but I would have had to miss the dance." Garth Brooks


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British Cocktail Shaker with Citrus Juicer browse these categories for related items... Directory: Vintage Arts: Decorative Art: Metals: Silver: Plate: Pre 1930: item # 1176466 Please refer to our stock # 203 when inquiring.
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A large classic cocktail shaker with Art Deco fluted element at the mid-section. This strainer section removes to reveal an internal citrus reamer or juicer. Ready for a twist of lemon, lime or orange to create the perfect cocktail recipe. Made by James Deakin in Sheffield circa 1925. 8 3/4" H. |
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Book Recomendations PHP , MySQL, Javascript etc to create Online Discography
Hello to everyone,
Tudor here ! This is my first post and first of all i would like to thank everyone that might post here and might help me in my quest.Also big thanks to O'Reilly.I am a beginner in web development currently reading "Learning PHP, MySQL, and Javascript - A Step-by-Step Guide to Creating Dynamic Websites" which is a fantastic book by Robin Nixon. What i want to create is an Online Discography (which is a similar concept to Discogs.com),and what i want to know are titles for books or references that will help me fulfill my goal. . I would appreciate it if anyone could Structure the books (or other references, video,etc) on 3 MAIN categories. - since i am a beginner ! something close to this. Beginner. 1. book1 2. book2 ........... Intermediate 1. book1 ........... Advanced 1. book1 2. book2 As many books as possible, and every single info will help me. About anything , PHP,MySQL, Javascript,Ajax,(X)HTML(5),CSS(3),and so on. from the most simple to the most advanced. Many thanks and wish you all the best! Kind regards, Tudor. 4 Replies
Hi Tudor,
I'm glad to hear that the book you're working through now is going well for you! There are lots of books that may help you; here are the ones that I could think of. Beginner web development resources: Head First HTML with CSS & XHTML Creating a Website: The Missing Manual, Third Edition CSS: The Missing Manual, Second Edition Javascript and jQuery: The Missing Manual, Second Edition Intermediate/Advanced: High Performance Websites Even Faster Websites PHP Cookbook, Second Edition High Performance MySQL, Second Edition PHP: The Good Parts Javascript: The Good Parts HTML & CSS: The Good Parts References: HTML & XHTML Pocket Reference, Fourth Edition SQL Pocket Guide, Third Edition Javascript: The Definitive Guide MySQL in a Nutshell, Second Edition I hope this helps! Regards, Rachel James O'Reilly Media
Dear Rachel,
Thank you very much for guiding me. I will get all those books you recommended and start working hard. I was a bit sad when seeing the number of views going up on the post and no one replied. Once again thank you, and if anyone has other ideas, i am all ears ...and eyes! Kind regards, Tudor
Comment by
: Aug 09 2011 06:39 AM
+1 with Rachel selection specially the two books written by Steve Souders:
High Performance Websites Even Faster Websites You must read both in order to build powerful website. |


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text: Martha Hutchinson Administrative Assistant for Mary Anne Nuskin firstname.lastname@example.com Assistant Principal Reno Medina firstname.lastname@example.com Roberta Blank email@example.com At Earl Warren we value learning, character, respect, and personal responsibility. These values are seen in the classroom as well as throughout our campus by offering every student an opportunity for success. Earl Warren encourages the growth of lifelong learners, and increasingly competent, self-sufficient young people who are optimistic about the future. |


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By Kaitlin Shawgo | IDS
POSTED AT 12:16 AM ON Nov. 19, 2008
PRINT | Email |Editor | SHARE | RECOMMEND (0) | COMMENTS
Technology will have a chance to grow and hatch at IU, thanks to the groundbreaking of a new "incubator" and a $15 million grant from Lilly Endowment, Inc.IU President Michael McRobbie announced the hefty grant Tuesday at a groundbreaking for the new $10 million Bloomington Incubator, which will sit on the corner of 10th Street and the 45/46 Bypass. The incubator, part of IU's new Innovate Indiana initiative, will house new start-up companies relating to technology and the life sciences, according to an IU press release. It will essentially act as a technology "think tank," IU spokesman Larry MacIntyre said.The grant, which will be distributed over a five-year period, will go toward creating the Pervasive Technology Institute, one of the first programs to be housed in the incubator, MacIntyre said. "It's important for IU because this is one of our cutting-edge initiatives," MacIntyre said. "The labs that are part of this are nationally known. It's a step forward for us."The institute will be made up of three different research areas. A Digital Science Center will work to create a more usable network infrastructure. For example, it will enhance supercomputers to make them more useful to scientists. The Data to Insight Center will work with new tools to make sense of large amounts of digital data. The Center for Applied Cybersecurity Research will work to protect users' privacy on computer networks, according to an IU press release."In addition to inventing things and ideas, they're also responsible for thinking up policy-type questions and answers, such as how we handle individual privacy in a computer age," MacIntyre said.The institute is based on success from the Indiana Pervasive Computing Research Initiative, which was created in 1999 with funding from the Lilly Endowment, according to an IU press release. The initiative helped create the Pervasive Technology Labs and the School of Informatics, MacIntyre said.Other companies housed in the incubator will likely include those involved in life sciences, MacIntyre said.
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Rome Trip Report (2 of 2)
Agata e Romeo: I wanted to love this restaurant more than I did. I was impressed with the technical skill of the dishes, impressed with the quality of the ingredients, and blown-away with the extra-ordinary service. Ultimately, however, I have a serious criticism about the repeated use of turbot in the Agata e Romeo tasting menu. The restaurant's cooking style lets the natural flavors of the ingredients speak for themselves without too much embellishment. Conceptually, I have no problem with that approach. In reality, I have a problem when one ingredient takes a star turn over and over without much variety in sauces or preparation.
Dinner began with an amuse that was a mousse of turbot with a sea urchin sauce. I know sea urchin is a controversial ingredient, but I've had it in several dishes and really enjoyed the flavor. Oddly, I got a strong taste of liver in the amuse in spite of the fact that the dish, as explained, contained no liver. (I like liver, too, so that wasn't a problem.)
The first course was lobster prepared two ways -- a terrine of lobster and a lobster claw -- accompanied by salad of mache. There was a wonderfully intense lime sauce drizzled over the lobster claw and the salad. The lobster terrine was bland and would have benefitted from a drizzle of the superb lime sauce.
The next course was foie gras prepared three ways: grilled fresh foie gras, pate, and foie gras creme brulee. The last item was totally amazing, probably my favorite dish in the whole meal. The dish included a fig chutney that was sublime and a whole fig in heavy sugar syrup. These two accompaniments were a great addition to the grilled foie gras, in particular.
We next ate risotto topped by a scallop. This was a tour de force demonstration of how to make a good risotto.
The next course was described as ravioli of fish soup (ravioli di zuppa de pesce). Part of my disappointment about this course was one of expectations. I had anticipated an Italian version of Xiao Long Bao (Shanghai soup dumplings). In fact, the dish turned out to be ravioli filled with a puree of turbot. The ravioli were served in a bit of broth accompanied by a small piece of turbot and a head-on shrimp. The dish was really tasty, but double appearance of turbot was not a selling point for me. My husband felt that the texture of the ravioli filling was too reminiscent of the texture of the lobster terrine.
Up to this point in the meal, everyone got the same food. At this stage, diners selected the next course choosing between pigeon accompanied by pigeon-liver mousse and turbot wrapped in leeks and accompanied by a dice of mixed vegetables. My husband and I love fish. We eat it essentially seven days a week so the relatively few options was not a problem. However, the third appearance of turbot continued the serious lack of imagination and was a problem. With all the lovely fish available in the region, I was, and continue to be, utterly bewildered why the kitchen would send out turbot three times.
I mentioned the technical excellence of the food and this dish was a good example. Someone in the kitchen has super knife skills. The size of the diced vegetables was amazingly tiny and staggeringly uniform. Very impressive. While I can admire such arcane details, ultimately, I judge a restaurant by the taste and I was somewhat let down by eating turbot again.
The next course certainly broke new ground! It consisted of gorgonzola gelato surrounded by some honey and topped with a sauce of melted hard gorgonzola cheese. I liked the flavors, but the gelato had a lumpy texture when cold. Once the gelato melted in my mouth, the texture issues disappeared and I could focus on the fascinating taste.
The next dessert was a tower affair consisting of two paper-thin rectangular cookies of chocolate layered with a custard cream and raspberries. Lovely. This pastry was accompanied by vanilla gelato with rum served in a Florentine cookie tuille.
The final dessert consisted of three types of ultra-mini pastries: a baba and two types of cookies. Each ranged in size from a US quarter to a US nickel. Again, the technical skill to produce such delectable minis was very impressive.
We drank Italian champagne throughout the entire meal. (The server made it very clear that we would be drinking champagne and not spumante or prosecco.) This was a wonderful accompaniment to the dishes.
Since I collect teapots, I loved the restaurant's decoration. Wall-sized grids of dark-stained wood provided display space for Agata's teapot collection. Along one wall, there was a high shelf lined with teapots that were too big to fit into the niches of the grid. Twice, I saw a waiter walk over to the wall and take down a teapot. A short time later, the teapot appeared on someone's table. I thought this was a neat touch.
Purse stools! Hooray!
Immediately after the meal, my husband and I said that despite being an impressive meal, ultimately dining at a super high-end restaurant is not why we enjoy eating in Italy. Over time, our feelings changed somewhat to focus on the lack of variety. We thought back to other high-end tasting meals we've eaten (e.g. Jean-Georges in NY) and recalled our positive feelings about the succession of tastes throughout the meal. Would I go back to Agata e Romeo? Not sure. If so, we'd probably try the traditional tasting menu, although I suspect we'd first head back to Il Convivio. Still, our visit the next night to Antico Arco makes a future visit to either Agata or Convivio less likely. This restaurant is not Agata's equal, but it compares very favorably with regard to cooking skill and decor. Service is extremely polished, definitely closer to the Agata model than to the trattoria model. And all this at a price that is only slightly more than half the cost of our meal at Agata.
Antico Arco: This is a sleek, modern restaurant serving innovative, well-executed food. You'll need to take a taxi to get to this out of the way location, but the views driving up to the top of the hill are lovely. After carrying on about the repetition of ingredients at Agata, you'll note a bit of inconsistency in my positive feelings about Antico Arco considering there was a lot of cheese in this menu. However, both the type of cheese and the treatment of each dish showed enough variety that we were totally happy with our meal.
We began the meal with an amuse consisting of a slice of poached octopus inserted into a bed of mashed potatoes mixed with olives. Outstanding.
The first course was delectable; we were swooning and yet, as the other courses were presented, this yummy food eventually fell to third place. The menu calls this dish " Mozzarella di bufala croccante, bottarga di tonno e pomodori confit." The dish consists of a ball of mozzarella wrapped in a few sheets of puff pastry and baked. The dish was finished by shaved bottarga and strips of semi-dried tomatoes.
The menu describes the next course as "Tortino di Burrata alici e fiori di zucca." I'm not sure about the tortino part; I'm not persuaded that a portion of melted burrata cheese qualifies as a tortino. Nevertheless, we enjoyed this dish with its appealing combination of flavors: cheese, fresh anchovy, and zucchini blossom.
Question: I'm not clear about the difference between alici and accughe? Is one fresh and the other salted or marinated? When would someone use one word versus the other word?
The regular sequence of the tasting menu would next serve tagliatelle with gray mullet and saffron. However, in our internet research we'd become attracted to one of the restaurant's signature dishes, a cheese risotto served with a nebbiolo sauce. We asked if we could substitute the risotto for the tagliatelle. A quick inquiry of the chef and our request was honored. I now present the star of the meal: Riso Violone Nano, Castlemagno, e Riduzione di Nebbiolo. Fantastic! The wine sauce was an incredibly delicious foil for the amazing cheese risotto.
The pasta Amatriciana was delicious and would have been a star in another setting but it followed the amazing risotto and was merely good in comparison. (The pasta was half-paccheri, a pasta that we would come to know and love in its full dimensions in Amalfi and Naples.)
I was nervous about the next course since I'm not a big fan of sweet with meat and the word "agrodolce" jumped out at me when reading the menu. (If asked if I wanted the English or Italian menu, I take one of each. My menu Italian is my best Italian; actually it's quite serviceable Italian except for local pasta names and some more arcane words. I knew the word for pork, but the words for suckling pig sent me scurrying to the English menu.)
I should have had more confidence in this excellent kitchen; the sauce was very light and appealing -- not the least bit cloying. The dish consisted of two slices of pork tenderloin set vertically on the plate. They were linked by a log-shaped piece of ultra-crisp skin so the total effect was that of a bar bell. This was topped by a second piece of skin. By deconstructing the dish, the kitchen was able to deliver each element optimally -- moist meat and super-crisp skin.
Pre-dessert was an appealing pear panna cotta. The cheese course consisted of three cheeses, a hard cheese, a soft cheese, and gorgonzola. (Sorry, I can't remember the types of cheese.) These were accompanied by a tomato-horseradish chutney, a lemon-celery chutney, and honey.
The silver medal dish of the evening was dessert: mojito sorbetto. At least the menu called it sorbetto. I think granita is a more accurate description of the texture. Each portion of this dessert is made to order. The ingredients of the sorbetto/granita are exactly those of the drink. The jolt of lime and the rum were a perfect ending to this outstanding meal.
Food and fun with Maureen Fant: We spent a very special day with Maureen visiting Volpetti's and the Testaccio market and feasting at Checchino dal 1887. We arranged this experience through ContextRome, an excellent day-tour organization. (We would later take a considerable number of their day tours in Naples.) The official title of the experience is Annotated Lunch. I think "The Pleasure of Maureen's Company – Along with Really Delicious Food" is a much more evocative title.
Incidentally, Context Rome and Context Naples offer two types of tours: private and small group. Although there is a calendar for the small group tours, if you want to take a specific tour but it isn't offered on a convenient day write the office and ask about their adding a small group tour to the public calendar. That's what we did for our day with Maureen and for all our tours in Naples. Maureen also offers a more hands-on cooking experience through her own web site. Regardless of which experience better meets your needs, you'll find Maureen to be a knowledgeable, charming, and enthusiastic person to help you better appreciate Roman and Italian food. Kudos! (How would I say this in Italian? Brava? Bravo?)
Maureen has a close relationship with Volpetti and this benefits those of us in her charge. We were showered with samples of white-belt pork salami and proscuitto, marinated mushrooms, olive oil, and balsamic vinegar. Of course, our group – two couples – responded by enthusiastically buying food.
(For the flight home, we kept the balsamic in its original protective packaging and carried it in our on-board luggage. The bottle did meet the 100 ml restriction, but the protective wrapping was too large to fit inside a plastic baggie. Nevertheless, our arrangements didn't even produce a raised eyebrow from security in our departure city, Naples. We didn't have to go through security for our connecting flight back to the US in Munich. Two years ago, we got static about our balsamic bottle not being in a baggie in both our departure city, Bologna, and our change of plane in Paris.)
The tour of the market in Testaccio was fascinating. Maureen identified some foods that were wholly new to us. Even familiar food looked fresher and more appealing than food we can find locally until farmer's market season. We bought oranges from Sicily to eat for breakfast the next day and they were merely amazing!
The food and the company at lunch at Checchino combined for a memorable experience. No one ordered any of the hard-core offal dishes (e.g. pajata), but we didn't exactly wimp out either. I'll try to remember what everyone ate, but I might not be able to do so since we consumed amazing quantities of excellent food. In fact, we never did eat dinner that night. At some point, we nibbled on a bit of our food from Volpetti and consumed the rest for breakfast the next morning. (In Rome, we stayed in an apartment in the Monti district.)
For the primi course, I think our group was split between pasta carbonara and bucatini alla gricia. Maureen explained that the latter is simply carbonara without the egg. My husband got the carbonara, and I got the alla gricia. We shared tastes and both agreed that mine was the better dish. My husband felt the egg diluted the flavors of the cheese and guanciale. At home, I've only seen ground guanciale. The version at Checchino featured thin small pieces of the meat. This produced a more successful dish. While eating, I could distinguish each element so I encountered a succession of tastes instead of a homogeneous taste. Lovely.
Although I was considering ordering the grilled sweetbreads, I ultimately ordered a great lamb dish whose name I don't remember. I only have the word "abbachio" in my notes. It consisted of chunks of braised lamb coated with lemon, egg, and parsley. The lemon added a brightness to the dish without being as sharp as a Greek avgolemono sauce. Absolutely delicious! (I like sweetbreads but I'm used to a saute with a bit of sauce. The unadorned grilled version offered at this restaurant seemed too austere.) My husband adored his oxtail, Coda alla Vaccarina. I know that one person in our group ordered the coda cacciatore, but I think we were otherwise split between the lamb dish and the oxtail.
We also ordered contorni for everyone to share: vignarola and broccoli rabe. Both delicious.
More sharing ensued when we got the last piece of apple cake in the restaurant along with a thoroughly decadent piece of stracciatella cake. And, as if that weren't enough, we nibbled on excellent cheese platters.
At the end of the day, we were hugging one another as we said our good-byes. That's the sort of comfortable rapport Maureen establishes with her group. A memorable experience on many levels.
Il Gelato di San Crispino now has a branch located somewhat north of the Pantheon. It's in the pedestrian route between the Corso and the Piazza della Rotonda. I assume the original location near the Trevi Fountain still exists.
I totally concur with Indy's review of Agata. We had the exact same tasting menu and with similar reactions to the service (excellent and warm), food (cosi cosi - easy on the turbot please!), setting (pleasant). The wine pairing was a bit strange with the various courses - I would advise sticking to the franciacorta they serve in liberal portions.
Also, the comments about Colline Emiliane are spot on. The food is delicious, the service gruff and the colatello, well, tough. Reservations a necessity for lunch and dinner.
As a side note, we had a great lunch at Capranica on Monday (when many restaurants are closed). Capranica has three Michelin forks and is a very staid and reserved upon entering. However, the new chef is a true artist - fantastic flavors and going in directions on the nouveau side of things where Agata falls flat. The servers could not have been more welcoming and well informed and eager to please. We went as a lark after touring the Vatican and were very pleased at the experience, albeit expensive one.
Sad to report our two trips to San Crispino in April were decidedly bad. Tossed out both cups on our first visit. Save for the chocolate, the gelato was tasteless and gritty. Based on an earlier post here, we opted for apple, pear, pistachio, chestnut...all mediocre.
Maureen has lauded Alberto Pica in Largo Argentina - far better choice than the S. Crispino. Wonder if the expansion to the new store has adversely affected the quality?
re: wristband
So glad someone else had the courage to buck the guidebooks. Crispino was terrible. For the first and only time in our lives (and we have spent months in Italy over the years and eaten lots of gelato) my wife and I took two bites of each flavor we selected and tossed the rest in the trash.
re: GeraldI
Yes, I agree that San. Crispino is way overrated. Try a little hole-in-the-wall place in Trastevere for THE BEST gelato - called "Giorgiagel" on Via. S. Francesco a Ripa.
or read my blog report on Rome gelato at http://ciaochowlinda.blogspot.com/200... -
great write up. my visit to rome and the south was near the same time as yours. also, i had similar restaurants in scope though my final choices were all different this time. heck, i even contacted maureen at the last second regarding a visit to the markets, but no luck--perhaps because of may day?
there's just something so cool about renting an apartment in rome and living on the economy.
my modest contribution to this wonderful thread is this: walk the neighborhoods and gravitate toward restaurants that "talk" to you. sometimes we all get a little too consumed by our quest for the best. restaurants love repeat customers. find a local place you enjoy and go back. it will be like a family homecoming. food, service and personal attention will be kicked up a notch.
one last thing: deb and i are charter members of the maureen fan club.
re: steve h.
Thanks, steve h. - I really needed to hear that! I'm making a few reservations for the places high on my list (Paris, Al Ceppo, Armando & ColIine Emiliane). However, I've really been struggling with our other meal decisions and just last evening I decided to leave the rest of the choices open and let serendipity lead us.
We are going to be in Rome for 6 days and have a lot of sightseeing planned, however, we also have a lot of free time for wandering and exploring. I have a feeling those explorations will lead us in the right direction.
And if we have a clunker...sometimes it's those not-so-great experiences that can be memorable for their comedic material. (Believe it or not, we ate excellently on our trip to Ireland, however, the funny happenstances of our two worst meals still make us a chuckle.)
Great report, both parts. You've given me lots of ideas.
On my last trip, our final evening in Rome we had a taxi driver drop us off at San Crispino by Trevi after dinner. On the walk back to apartment we discovered the new San Crispino. Gluttony beat goodness (again!) and we had a second gelato.
re: Leely2
I've already posted what I'm about to share, but it's very appropriate. Compared to the individual below, you have nothing to feel guilty about!
Favorite conversation overheard in Italy. (Overheard on Corso Vittorio Emmanuelle):
Wife: What do you want to do about breakfast?
Husband: Get some gelato.
Wife: But it's breakfast! You really can't want to eat gelato.
Husband: It's my last day in Rome. I'm going to have gelato for breakfast and after lunch and dinner. And if I feel like having some gelato in between meals, I'm going to!
You can't see me blushing, but I'm deeply honored by your enthusiastic report. Let me try to fill in a few details. I also want to clarify something. My close relationship with Volpetti is based more on the amount of treccia di bufala my husband is able to consume in a year than on the fact that people I take there occasionally buy balsamic vinegar. I've been shopping there for nigh on thirty years. The white belt pork is Cinta senese, an heirloom pig from southern Tuscany which gives the most wonderful salami and prosciutto. We also ate the pork chops once at an agriturismo in Tuscany, and my next experiment will be making pasta alla gricia with the guanciale.
The lamb dish is abbacchio brodettato and they make it at Checchino only in the weeks around Easter. I agree that gricia is better than carbonara. Never heard of grinding guanciale. That's terrible. The coda doesn't come alla cacciatora. That would be lamb. The other manifestation of the coda is in tonnarelli al sugo di coda, the tomato sauce in which the oxtail stewed for several hours.
re: mbfant
Wow !! I am overwhelmed, and from this description, sooo jealous! Thank you so much for the wonderful report ... we are looking forward to trying all your choices as well. I was unaware that MBFant was available to guide one through such interesting culinary adventures ... I will remember that for future travels! Surely, you are better versed than I in the menu choices, so I am sure I would benefit even more from an on-site tutorial by Maureen of the fare available at this level!! And, by the way, I was so involved in your descriptions of the meals you had that I think I missed which were at Convivio, or are you posting later on that?? Antico Arco is much raved about lately ... now I know specifically why ... we will go there first and then compare against that! Thanks for your great report.
re: PeggyD
Hmmm. Your question about Il Convivio makes me realize how badly I garbled my last paragraph. My husband and I ate at Convivio our last trip to Rome not this trip. When we were debating between Agata and Convivio for our insanely big splurge, Agata won the toss both because it was new to us and because we could walk there from our apartment. We love being able to walk to sites and restaurants -- great break from our typical suburban routine and imperative if we want to keep our weight somewhat under control.
re: mbfant
"The other manifestation of the coda is in tonnarelli al sugo di coda, the tomato sauce in which the oxtail stewed for several hours."
Thank you, mbfant! I had this in January and couldn't for the life of me remember what I had ordered. It was possibly my favorite dish that trip. I followed it with a lamb dish that had a distinctive kick (insert joke about how it must have been donkey if it kicked, har har). Maybe a bit of anchovy and red pepper flake? It almost seemed like something I could replicate at home....?
Indy, we went to Antico Arco twice in one week--partially because I got a little confused making reservations using my "Italian"--first night did the tasting menu, second time a la carte. The service was gracious both times, but positively effusive our second visit. Nice wines.
Okay, this is making want to return to Rome straightaway.