text:
Communication from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions - Safe, Innovative and Accessible Medicines: a Renewed Vision for the Pharmaceutical Sector
/* COM/2008/0666 final */
html | html | html | html | html | html | html | html | html | html | html | html | html | html | html | html | html | html | html | html | html | html | ||
doc | doc | doc | doc | doc | doc | doc | doc | doc | doc | doc | doc | doc | doc | doc | doc | doc | doc | doc | doc | doc | doc |
Bilingual display: BG CS DA DE EL EN ES ET FI FR HU IT LT LV MT NL PL PT RO SK SL SV |
[pic] | COMMISSION OF THE EUROPEAN COMMUNITIES |
Brussels, 10.12.2008
COM(2008) 666 final
Safe, Innovative and Accessible Medicines: a Renewed Vision for the Pharmaceutical Sector
Safe, Innovative and Accessible Medicines: a Renewed Vision for the Pharmaceutical Sector
1. Making further Progress towards a Single and Sustainable Market in Pharmaceuticals 4
1.1. Better Access to Medicines for European Patients 5
1.2. Better Regulation for a More Competitive Industry 7
1.3. Safer Medicines for Better Informed Citizens 8
2. Taking on the Opportunities and Challenges of Globalisation 10
2.1. Tackling Worldwide Health Challenges 10
2.2. Towards Global Cooperation and Harmonisation 11
2.3. Towards Global and Fair Competition 13
3. Making Science Deliver for European Patients 14
3.1. Supporting Pharmaceutical Research 14
3.2. Keeping the Pace: New Horizons in Medicine 14
4. Conclusion 15
The pharmaceutical sector makes an important contribution to European and global well-being through the availability of medicines, economic growth and sustainable employment. It has been and remains a strategic sector for Europe. It employs more than 634,000 people and accounts for more than 17 % of the EU Research and Development (R&D) expenditure. Most importantly, innovation in human medicines has enabled patients to benefit from treatments considered unimaginable a few decades ago. Demographic change, i.e. ageing, is a global phenomenon which will affect western societies as well as major emerging economies like China and Russia. Hence health-related services and products are growth markets worldwide and offer a potential for Europe's well- established pharmaceutical industry.
Since 1965, Community action in the field has always had the dual objective of safeguarding public health by providing Europe with safe and effective medicines, while at the same time creating a business environment that stimulates research, boosts valuable innovation and supports the competitiveness of the industry. Much has been achieved in forty years. However, at the beginning of the 21st century Europe faces major health, economic and scientific challenges[1]:
- Europe has been losing ground in pharmaceutical innovation. The centre of gravity for research has moved to the US and Asia. New international competitors emerge. In the 1990s pharmaceutical research and development expenditures in Europe were higher than in the U.S. (EUR 7.766 billion compared with EUR 5.342 billion). However, the picture had changed by 2006 (EUR 22.500 billion in the EU while EUR 27.053 billion in the U.S). With regard to research sites a similar trend can be identified. Between 2001 and 2006 18 research sites of 22 global pharmaceutical companies were closed in Europe (only 2 were opened) while in the same period these companies opened 14 research sites in Asia (one was closed) and six in the U.S. (five were shut down). While in general the number of new pharmaceutical substances has decreased worldwide, the decrease has been significantly sharper in the EU than in the U.S. and other parts of the world.
- Shortcomings in the availability of medicines have been identified . In 2008, European patients still suffer from inequalities in availability and affordability of medicines. The last legislative review[2] and the creation of the High Level Pharmaceutical Forum[3] are major steps forward, but some key issues remain open. Future proposals of the Commission will also have to take into account the findings of the ongoing pharmaceutical sector inquiry.
- The sector is more and more globalised . Globalisation brings new opportunities with the opening of new markets. Industry sales outside the traditional markets, i.e. industrialised regions like the U.S., Europe and Japan, are increasing significantly. At the same time, worldwide cooperation and trade lead to a global division of labour. Hence a new medicine is often the result of research and development in Europe, clinical trials in India, and active ingredients produced in China before finally produced, packaged and sold in the EU. This "global" reorganisation creates new opportunities but also new challenges, in particular counterfeit medicines are on the rise.
- Scientific breakthroughs revolutionize the way medicines are developed and prescribed. Treatments become more personalised. Linked to the ageing of the population and to a proactive involvement of patients, the demand of society is also evolving. At the same time unmet medical needs are to be met, e.g. infectious diseases (like tuberculosis and HIV/AIDS) and rare diseases whose ramifications are not limited to the EU but pose global public health challenges.
To address these challenges, this Communication outlines the Commission's vision of the future of the sector and intends to trigger a process which leads to a way forward. Based on three pillars, concrete objectives are proposed:
1. To make further progress towards a single and sustainable market in pharmaceuticals and;
2. To take on the opportunities and challenges of globalisation;
3. To make science deliver for European patients and restore the EU's role as the natural home for pharmaceutical innovation.
The Commission's vision is to ensure that European citizens can increasingly benefit from a competitive industry that generates safe, innovative and accessible medicines . Many initiatives have been taken in this direction, most recently with the inclusion of eHealth in the Commission's lead market initiative that aims to remove barriers to the acceleration of market development[4]. The five accompanying legislative proposals (on counterfeiting, information to patients and safety monitoring[5]) are further important steps towards this vision, while other concrete objectives are listed in the Annex.
Major progress has been achieved over the last years. Legislative initiatives of the Commission have led to improved marketing authorisation procedures, the harmonisation of data protection in the EU, better access to medicines for children, and a new regulatory framework for advanced therapies like tissue engineering. Furthermore the Guiding Principles concerning pricing and reimbursement developed by the Pharmaceutical Forum are major steps. Nevertheless stakeholders continue to raise concerns with regard to the market fragmentation linked to disparities in national pricing and reimbursement schemes, unnecessary regulatory burdens caused by divergences in the implementation of Community legislation, and a lack of commercial interest in national markets which are economically less attractive.
This situation may create important inequalities between patients in the access to medicines while the growth potential of the EU industry is hampered.
Completing the single market in pharmaceuticals remains an important objective.
Better Access to Medicines for European Patients
Ensuring Affordable Access to state-of-the-art Treatments without Delays
The lack of critical medicines in particular due to a lack of adequate financial resources is an issue that has reached the highest political level, as exemplified by the 'Bremen Declaration'[6] in the case of HIV/AIDS, where Health Ministers committed to cooperate to order to ensure access to affordable medication in view of existing problems for patients in several Member States to have access to urgently needed medication.
The lack of available of medicines has also been highlighted in a recent report of the Heads of Medicines Agencies[7] and by the Pharmaceutical Forum[8]. The problem is particularly striking in those Member States where the national market is small and the expected return on investment for companies is low.
This has important public health consequences in several Member States, despite improvements due to the last review of the EU pharmaceutical legislation. In the short term, minor changes to the regulatory framework (e.g. on linguistic regimes and labelling) can be made to improve the situation. However, a more in-depth review of the situation is required to fully address the issue. Beyond regulatory aspects the role of full-line and public wholesalers[9] in the supply of medicines in small markets needs also to be examined in more detail.
More broadly, the functioning of the network of EU medicines authorities requires re-thinking to improve its efficiency, minimise the regulatory burden it generates and thus speed up market access for medicines.
Objective #1: Options to improve the availability of medicinal products for patients in need , with a particular focus on smaller markets should be developed in close cooperation with Member States by 2010.
Objective #2: Based on an evaluation of the European Medicines Agency (EMEA) ways to optimise the functioning of the network of EU medicines authorities should be identified by 2010.
The fragmentation of the EU market primarily relates to the diversity of national pricing and reimbursement schemes. Decisions on costs of healthcare and pharmaceuticals are a national competence but must comply with Directive 89/105/EEC and the EC Treaty, requiring in particular that pricing and reimbursement decisions are made in a timely and transparent manner.
Allocating healthcare funds to the most effective medicinal products as well as creating the right environment for price competition is of major importance to ensure the sustainability of healthcare systems. Different systems lead to disparities in pricing, time-to-market delays and access inequalities. Member States are entitled to make political choices on which medicines to reimburse, in line with the provisions of the Transparency Directive, and to take decisions which take into account the effectiveness and value for money of innovative medicines as well as the budgetary constraint in Member States.
However, availability and affordability of medicines have a European dimension.Different national pricing and reimbursement schemes create a complex landscape in the EU while Member States face the common challenge of balancing three overarching objectives: optimal use of resources to ensure sustainable financing of healthcare for an ageing European population, access to medicines for EU patients and reward for valuable innovation. A common set of Guiding Principles[10] has been adopted by the Pharmaceutical Forum to support future national pricing and reimbursement policies. The positive experience of information exchange and cooperation between Member States and with stakeholders should be strengthened at EU level.
Similar price levels can lead to a different level of affordability depending on the economic situation in each Member State. More efficient market mechanisms and, in particular, price competition for non-reimbursed medicines, would provide, in this sector, more patients choice at a more affordable cost. Member States should, therefore, remove price controls on manufacturers that prevent full competition of authorized medicines that are neither purchased nor reimbursed by the State.
Further development of health technology assessments will also offer valuable support to national authorities to strike a balance between containing pharmaceutical expenditure and ensuring a fair reward for valuable innovation and access to the best available medicines. Cooperation among authorities and dialogue with stakeholders will be a prerequisite to achieve such a balance. Based on the agreement found in the Pharmaceutical Forum the exchange of data between Member States on relative effectiveness should be fostered.
Objective #3: Genuinely transparent and speedy pricing and reimbursement decisions should be made possible by enhancing the application of the Transparency Directive .
Objective #4: Based on the work of the Pharmaceutical Forum the exchange of information and the cooperation among stakeholders on pricing and reimbursement should be improved.
Objective #5: Based on the agreement found in the Pharmaceutical Forum the exchange of data between Member States on relative effectiveness should be fostered in order to avoid delays in the market access of innovative treatments.
Improving Competition and Market Access
Competition is an efficient way to stimulate valuable innovation and improve medicines' affordability. In January 2008, the Commission has launched a sector inquiry into the pharmaceutical sector on the basis of Article 17 of Regulation No 1/2003[11]. The inquiry concerns " the introduction of innovative and generic medicines for human consumption onto the market" [12] . The inquiry was initiated as certain circumstances in general suggest that competition may be restricted or distorted in the pharmaceutical sector in Europe, such as a decline in innovation as measured by the number of novel medicines reaching the market and instances of lacking timely entry by suppliers of generic medicines. The main focus of the inquiry is the commercial behaviour of market participants affecting market entry of competing novel or generic medicines. The preliminary results will be presented in a report scheduled for 28 November 2008. The final report is foreseen for spring 2009.
In addition, the Commission plans to launch an in-depth monitoring of the functioning of markets in the pharmaceutical sector. This action is part of the follow-up to the November 2007 Single Market Review which aimed to improve the governance of the Single Market through a systematic and integrated market monitoring of key markets.
The Commission will take into account its findings in the ongoing pharmaceutical sector inquiry and this market monitoring exercise when making future legal proposals.
Many Member States recognise that generic medicines play an important role in helping to limit their healthcare expenditure in their reimbursement and prescribing practices. Competition with off-patent products enables sustainable treatment of more patients with less financial resources. The generated savings create financial headroom for innovative medicines. All actors should therefore ensure that generics can enter the market after expiry of patent and data exclusivity protections and compete effectively.
Equally, non-prescription medicines also play an important role since they offer economic as well as social benefits. Self-medication empowers patients to treat or prevent short term or chronic illnesses which they consider not requiring the consultation of a physician or which may be treated by the people after an initial medical diagnosis. Consequently, access and availability of these medicinal products require particular attention.
Objective #6: Ways to ensure availability and market access for generics and non-prescription medicines should be examined by 2011.
Objective #7: Launch of an in-depth monitoring of the functioning of markets in the pharmaceutical sector.
Patients' expectations to health systems and quality of care in relation to cross-boarder healthcare also call for a more coordinated EU action. The proposed Directive on cross-border healthcare[13] sets out common principles to ensure safety and quality of care, a specific framework on cross-border healthcare and provisions for cooperation between national systems. The proposal also provides for cross-border recognition of medical prescriptions.
Better Regulation for a More Competitive Industry
Requirements that cause a high administrative burden without providing a clear public health benefit have a strong negative impact on the competitiveness of the EU industry. Small and medium-sized enterprises (SMEs) are economically affected in particular, e.g. in the field of pharmacovigilance redundant reporting requirements in different Member States create unjustified costs. Such obstacles may be decisive for these enterprises not to apply for marketing authorisations outside their Member State of origin.
However, in view of the fact that national regulators are involved in legislation and responsible for the implementation a high level of joint commitment is required from all actors in order to make pharmaceutical rules clearer, simpler and more flexible without compromising public health.
A better Framework on 'Variations'
The Commission recognises the burden that current rules on changes to the marketing authorisations of medicines ('variations') entail. This complex framework hinders the introduction of changes that are beneficial to patients and delays access to improved treatments.
Improving the Framework on Clinical Trials
A number of stakeholders have raised concerns (e.g. divergence in interpreting the relevant legislation and cumbersome procedures for multi-centre clinical trails in different Member States) over the application by Member States of the Directive on Clinical Trials[14] and its impact on academic as well as non-academic research. The recent EMEA-Commission conference[15] has identified shortcomings in applying the Directive. An in-depth assessment of the matter and recommendations for improvement should now be undertaken.
Objective #8: An assessment of the application of the Clinical Trials Directive with a view to making, if appropriate, legislative proposals - while taking into account the global dimension of clinical trials - should be presented by the Commission by 2010.
Safer Medicines for Better Informed Citizens
Improving Safety
Recent events linked to adverse reactions demonstrate that the safety of medicines remains a major public health issue. To tackle it, the Commission has submitted a legislative proposal[16] to rationalise and strengthen the EU framework on safety monitoring ('pharmacovigilance').
Objective #9: The proposal to rationalise and strengthen the EU framework on pharmacovigilance should be adopted swiftly.
Another important health issue also follows from the increased number of medication errors which have led to severe medical conditions for patients, such as medicine name confusions, and prescription, dispensing and administrative errors. To address this, the Commission has developed new strategies to reduce the scale of medication errors in the above mentioned proposal and to specify quality criteria for Health related websites[17]. The Commission has also confirmed that patient safety will be a priority for 2008, through a proposal addressing systemic patient safety issues, which aims to reduce all adverse events in healthcare, including medication errors, as well as specific measures aimed at the prevention and control of healthcare-associated infections[18].
Empowering Patients
As outlined in the Commission White paper on Health Strategy[19], patients are becoming more involved in the decision-making regarding their health. They have a right to more quality information on available medicines, the grounds on which they have been authorised and how they are monitored.
Public authorities and health care professionals have a crucial role in providing patients with relevant and impartial information. The Pharmaceutical Forum endorsed recommendations to enhance the generation, access and dissemination of good quality information on diseases and treatments. The use of quality principles and the increased cooperation among all partners for developing patient information should lead to tangible improvements for citizens.
However, information provided by public authorities currently varies considerably, and media such as the internet may not always provide reliable or understandable data. This became clear in a recent report prepared by the Commission in response to a request from the European Parliament and the Council[20]. On this basis, the Commission considers that the role of industry in this context should be clarified and presents a legislative proposal to rationalise the availability and improve the quality of information to patients within the EU[21] on prescription-only medicines. Industry should be given the opportunity to provide, under strict conditions, quality information. In that context, all actors and in particular industry and Member States should pay attention to the specific linguistic needs of patients belonging to minorities or with an immigration background.
Objective #10: The Conclusions and Recommendations of the Pharmaceutical Forum's work on information to patients on diseases and treatments should be taken forward.
Objective #11: Measures to ensure that the information provided by the industry to those who seek it is reliable and objective should be taken.
Addressing the Environmental Impact
Pollution of waters and soils with pharmaceutical residues is an emerging environmental problem and also an emerging public health concern. The Commission recognizing these concerns has funded several research projects to assess possible environmental and health impacts of pharmaceuticals. It is now necessary to focus on measures that could reduce the potentially harmful impact of pharmaceuticals on the environment and public health. Areas for further actions include evaluating environmental information on pharmaceuticals collected by the European Medicines Agency and national medicines authorities with a view to integrating this information into the current EU legislative framework.
Objective #12: Measures to reduce the potentially harmful impacts of pharmaceuticals on the European environment and public health should be proposed.
The EU pharmaceutical industry operates in a global economy. Globalisation brings important benefits, such as the opening of foreign markets and the rise in purchasing power, particular in emerging economies. Research-based as well as generic manufacturers see increasing market opportunities through public funding schemes as well as a growing number of patients who are able to pay for best available treatment options in emerging economies. The EU-based industry is responding to the changing environment in different ways. On the one hand innovators as wells as generic manufacturers are increasingly tapping into markets of emerging economies while outsourcing and internationalising research and development on the other hand. Furthermore, they increasingly rely on active pharmaceutical ingredients (API) imported from Asian countries as precursors for their finished products, thus maintaining their production capacity in the EU.
However, globalisation also leads to new public health challenges. Protecting European citizens by addressing these challenges is a priority of EU pharmaceutical policy. The Commission is also committed to improving medicine availability, affordability and access worldwide in the interest of global health.
Tackling Worldwide Health Challenges
Illegal Medicinal Products
The Commission has recently adopted a Communication on an Industrial Property Rights Strategy for Europe and a core element of the strategy is effective enforcement of Intellectual Property Rights. Illegal medicines exist in several forms, one of them being counterfeit medicines. Safety is a prerequisite for trade of medicines. A study launched in 2006 by the Commission on the distribution of pharmaceuticals revealed that a growing number of medicines are subject to counterfeiting in the EU.
The Commission "Report on Community Customs Activities on Counterfeit and Piracy" for 2007[22] also revealed that medicines seized by customs authorities increased by 628% in just two years (2005-2007). They relate not only to 'lifestyle' products, but also to treatments against life-threatening diseases. Existing contacts in regulatory cooperation with third countries should be intensified in order to combat illegal medicinal products.
On this basis, the Commission presents a legislative proposal[23] to effectively protect European citizens from this major health threat and ensure that medicines bought from the legal supply chain are fully reliable. Various means are proposed, ranging from product-related measures (such as obligatory safety features allowing traceability) to strengthened obligations for wholesale distributors. The proposal also addresses all other actors in the supply chain and clarifies their responsibilities.
Tackling counterfeiting requires joint international efforts. Bilateral cooperation with targeted third countries must be further developed. New mechanisms of exchange of information on illegal distribution channels and counterfeiting should be established.
The Commission is working intensively with European and international partners on this topic. It is an active member of the World Health Organization (WHO) International Medical Products Anti-Counterfeiting Task Force (IMPACT)[24], which has delivered principles on legislation against counterfeit medical products, and furthermore the Group of Specialists on Counterfeit Pharmaceutical Products (PC-S-CP) of the Council of Europe.
Objective #13: The proposal to prevent the entry of illegal medicinal products into the legal supply chain should be adopted swiftly.
Objective #14: An intensified exchange of information on illegal distribution channels in relation to counterfeit medicinal products should be proposed by 2012.
Objective #15: Within IMPACT, third countries developing and enforcing legislation against counterfeit medicinal products should be assisted by the Commission.
Preparing to combat Pandemics
The growing number of avian flu cases has proven that a comprehensive strategy in the field of infectious diseases, notably against pandemics, is necessary.
Much has already been achieved in this field, e.g. in facilitating the marketing authorisation of vaccines against pandemics. EU preparedness planning is well established[25] and a targeted legal framework has been set up under which several products against pandemic flu have already been authorised.
However, the international dimension of the EU influenza strategy, including UN (WHO, FAO, UNICEF etc.) and OIE, needs to be strengthened so as to provide EU citizens with effective vaccines without delays after an outbreak has occurred. Regulatory cooperation between the EU and third countries should provide a platform to share information on medicines against pandemics and to benchmark pandemic preparedness plans, as well as sharing influenza strains and improving access to vaccines and other benefits.
Objective #16: To improve international cooperation in the field of pandemics, existing bilateral and multilateral relations with third countries should be strengthened and extended.
Global Cooperation and Harmonisation
Strengthening international cooperation
Tackling worldwide health threats is in itself a sufficient reason to strengthen international cooperation. The global burden of disease is increasing, including poverty-related and neglected diseases which disproportionately affect developing countries. Recognising this, the EU played a constructive role recently in developing the WHO's new Global Strategy on Public Health, Innovation and Intellectual Property aiming at fostering the availability of innovative products addressing the public health challenges in these countries. The Commission has already begun to promoting research with and for Africa on new treatments for neglected diseases. The EU has also taken steps to enable international companies to provide medicines at substantial discounts to developing countries while ensuring that these preferential prices do not lead to negative repercussions in the EU market by reimportation. Furthermore the EU supports the Global Fund to fight against AIDS, Tuberculosis and Malaria in developing countries. The significant financial contributions from public as well as private sources like charities enable the Global Fund to boost prevention, treatment and care in order to accelerate the urgently needed response to these three diseases.
There are a number of other compelling grounds to strengthen international cooperation related to globalisation.
Firstly, a growing number of medicines are now developed in a multi-centre, international way. Clinical trials are often done outside Europe, including through the European and Developing Countries Clinical Trials Partnership (EDCTP). Ingredients and finished products are more and more sourced through international distribution channels. This makes the task of authorities (evaluation of trials, inspections of sites) more difficult and resource-intensive.
Secondly, companies increasingly operate worldwide. Side effects recorded throughout the world may be relevant to European patients as well. It is therefore essential that the EU has access to such information. Global monitoring requires global cooperation. The Commission is committed to addressing these challenges in a proactive manner. EU international cooperation has been significantly strengthened since 2005. Confidentiality arrangements with the US, Japan and Canada have been established. Yet, bilateral cooperation must still be further enhanced to better share information on the safety of medicines and coordinate actions. Mutually agreed mechanisms for inspections should also be agreed to avoid duplication of work.
Cooperation must be intensified with other key third countries ( e.g. Russia, India, and China) where more and more clinical trials are carried out and active ingredients produced. Compliance with the ethical principles of the Helsinki Declaration[26] must be a common objective for clinical trials in third countries. First steps have already been achieved, notably with India. Concrete initiatives such as training of regulators, information sharing procedures and work towards common standards should be initiated to increase mutual understanding and confidence.
Objective #17: The regulatory cooperation with the US, Japan and Canada within existing confidentiality arrangements, focusing on safety monitoring should be intensified.
Objective #18: Mutually agreed mechanisms for inspections in third countries should be proposed to these three countries by 2010.
Objective #19: Bilateral cooperation , including the research field, with Russia, India and China , focusing on clinical trials and the manufacture of active ingredients should be strengthened.
Objective #20: Training and information sharing procedures with these three countries should be fostered.
Promoting Global Harmonisation
Establishing and enforcing international public health standards is essential to minimise the risk that unsafe products enter the EU market. The work carried out with the US and Japan at the International Conference on Harmonisation (ICH) is essential in this context and must be expanded. ICH standards should be promoted so that they can become worldwide standards.
International cooperation also provides opportunities to strengthen the EU position by launching initiatives that benefit European companies. The EU-US Transatlantic Economic Council (TEC)[27], in particular, provides a unique chance to bring closer the two biggest pharmaceutical markets in the world, lowering costs by reducing unjustified regulatory divergences. Important simplification initiatives such as the action plan adopted after the Transatlantic Workshop on Administrative Simplification[28] have already been initiated. Joint upstream regulatory dialogue initiatives with other third countries could prove to be successful and should be further developed.
Objective #21: International harmonisation at ICH and the promotion of the use of international standards by third countries beyond the US and Japan should be further developed.
Objective #22: Using the TEC areas for simplification and convergence of rules between the US and the EU and engaging in upstream regulatory dialogue for major legislative proposals should be pursued.
Towards Global and Fair Competition
New markets (China, India, Brazil, Russia, Indonesia, Mexico and Turkey) are expected to represent one fifth of the global sales by 2020. Globalisation and the opening of these markets therefore bring major business opportunities for EU companies. At the same time, new competition from India, China and other Asian countries is emerging. These countries have already become centres in producing Active Pharmaceutical Ingredients (APIs) and prime sources for European imports of those substances.
Europe is in a good position to compete globally, provided the competition is fair, i.a. based on international rules. However, it is acknowledged that non-tariff barriers often impede market access for European operators while at the same time non-EU companies enjoy full access to open European markets. Therefore, the Commission has established cooperation in various areas relevant to pharmaceuticals with emerging trading partners in order to ensure that EU companies are able to compete on a level playing field in foreign markets, in particular that their competitors abide by the World Trade Organisation (WTO) rules.
Objective #23: The EU should work towards the implementation and enforcement of the WTO framework in its bilateral and multilateral contacts, including bilateral Free Trade Agreements (FTAs), in particular as regards the protection of intellectual property rights.
Supporting Pharmaceutical Research
Research and Development in life sciences is a key to pharmaceutical innovation. However, Research and Development investment has gradually been relocating from Europe to the United States and Asia. While certain factors are sector-specific others also relate to broader factors such as fiscal policy, cost of labour or education and training.
The Commission recognises the crucial role pharmaceutical research and development plays. It is currently implementing various sector-specific initiatives to foster innovation in this field. In 2006, the 7th Research and Development Framework Programme (FP7[29]) and the Competitiveness and Innovation Programme (CIP[30]) were adopted to support not only the development of new technologies, but also to ensure the early commercialisation of scientific findings.
The Commission will also in its planned Communication on rare diseases for the end of 2008 look into how it could strengthen its research and development efforts in relation to rare diseases.
The Innovative Medicines Initiative (IMI[31]) is a key measure to strengthen Europe's competitiveness in biopharmaceutical research and development. The objective of this new instrument, an industry-Commission public-private partnership, is to enhance and accelerate medicine development so as to make new treatment options available to patients earlier.
Keeping the Pace: New Horizons in Medicine
New technologies and therapies such as tissue engineering or nanomedicines and innovative information and communication technology (ICT or eHealth) tools for healthcare are emerging. They often lie at the borderline between various fields (medicines, medical devices, transplantation, ICT). Their emergence emphasises the importance of the proportionality and flexibility of the regulatory framework.
The Commission is committed to incorporating scientific breakthroughs into the EU pharmaceutical framework of the 21st century like tissue engineering and gene therapy and its translation into marketable products, in particular in areas with unmet medical needs, e.g. infectious diseases (like tuberculosis, HIV/AIDS) and rare diseases which do not only pose public health challenges for Europe but also for developing countries, particular in sub-Saharan Africa. All new technologies must however be evaluated properly. It is particularly important that the ethical pluralism and the principle of subsidiarity are fully respected.
Realising the promises of regenerative medicine
Regenerative medicine, i.e. the use of genes, cells and tissues to treat dysfunctions or regenerate parts of the human body, offers a huge potential, notably against diseases like Alzheimer or Parkinson which are of high prevalence in an ageing population. The new EU Regulation on Advanced Therapies[32] should speed-up the development of these products and foster industry's competitiveness, while respecting national prerogatives on ethics.
Objective #24: The effects of the implementation of the Regulation on Advanced Therapies should be assessed and reviewed by 2012.
Towards more personalised medicines
With the emergence of new technologies like pharmacogenomics and patient-specific modelling and disease simulators, personalised medicine is now on the horizon. In the long term, doctors may be able to use genetic information to determine the right medicines, at the right dose and time. This field is already affecting companies' business strategies, the design of clinical trials and the way medicines are prescribed. Although it is too early to say whether '-omics' technologies will indeed revolutionize the sector, the Commission closely monitors the area and will reflect on how it can support its development.
In addition, it has to be assumed that the high costs of these new treatment options are likely to put strains on public healthcare budgets. The deliberations in the Pharmaceutical Forum on matters related to pricing and reimbursement have set the ground to address these issues.
Objective #25: A report on the use of '-omics' technologies in pharmaceutical research and development should be submitted by 2010 and the subject as to whether new Community instruments are needed to support their development should be explored with stakeholders .
The Commission firmly believes that in today's globalised world and security environment, Europe needs a dynamic and competitive pharmaceutical sector. The EU has major assets to meet this objective: a strong research base, a renowned education system and skilled workforce, a well-established and innovative EU-based industry.
The future of the sector will be shaped by structural factors, some of which go beyond the sole pharmaceutical area. Nevertheless, the Commission underlines the major role that EU policy can play in this sector. Community action is most appropriate to tackle the challenges that Member States have in common. The commitment of all actors involved in the implementation of this Communication will be essential to achieve the intended vision: a competitive industry that generates safe, innovative and accessible medicines.
Based on the objectives outlined in the Communication, the Commission, therefore, invites the other institutions to engage in a constructive dialogue on the way forward.
[1] Similar challenges exist for veterinary medicine but are not covered by this Communication.
[2] OJ L 136, 30.4.2004 p. 1 – 33, OJ L 136, 30.4.2004 p. 34 – 57 and OJ L 136, 30.4.2004 p. 58 – 84.
[3] http://ec.europa.eu/enterprise/phabiocom/comp_pf_en.htm
[4] Communication "A lead market initiative for Europe" - COM(2007) 860 (21.12.2007). The Communication and all relevant documents are available at the official EC LMI microsite: http://ec.europa.eu/enterprise/leadmarket/leadmarket.htm
[6] http://www.eu2007.de/en/News/download_docs/Maerz/0312-BSGV/070Bremen.pdf
[7] Availability of Medicinal Products, HMA, 5/11/2007.
[8] http;//ec.europa.eu/enterprise/phabiocom/comp_pf_en.htm
[9] http://ec.europa.eu/enterprise/phabiocom/comp_pf_en.htm
[10] http://ec.europa.eu/enterprise/pharmaforum
[11] OJ L 1, 4.1.2003, p.1
[12] For further details: http://ec.europa.eu/comm/competition/sectors/pharmaceuticals/inquiry/index.html.
[14] OJ L 121, 1.5.2001, p. 34.
[15] http://ec.europa.eu/enterprise/pharmaceuticals/pharmacos/archives_en.htm, 30.11.2007.
[18] http://ec.europa.eu/atwork/programmes/docs/clwp2008_en.pdf
[22] http://ec.europa.eu/taxation_customs/resources/documents/customs/customs_controls/counterfeit_piracy/statistics2007.pd
[24] http://www.who.int/medicines/services/counterfeit/en/
[25] http://ec.europa.eu/health/ph_threats/com/Influenza/influenza_level_en.htm
[26] http://www.wma.net/e/policy/b3.htm
[27] http://ec.europa.eu/enterprise/enterprise_policy/inter_rel/tec/index_en.htm
[28] http://ec.europa.eu/enterprise/pharmaceuticals/pharmacos/archives_en.htm, 30.11.2007.
[29] http://cordis.europa.eu/fp7/home_en.html
[30] http://ec.europa.eu/cip/index_en.htm
[31] http://www.imi-europe.org
[32] OJ L 324, 10.12.2007, p. 121.
Top |


text:
Maple Lacquered Duck Breast
Author Notes: A few of my favorite things - duck, a little sweet, a little spicy, a little citrus. And simple - really this comes together in a snap. And as an extra added bonus you get to use the word lacquered. One simply does not get to say lacquered often enough .. - aargersi
Food52 Review: The combination of flavors in this recipe is delightful; classic duck & orange combo with a twist. The maple syprup adds a sweetness which is not too cloying and not immediately identifiable as maple (a plus, in my opinion). Salt the breasts abundantly and skip black pepper before placing in the pan; better to pepper later as the grounds will scorch. The dish is visually pleasing, as well; the pink flesh with orange zest, thyme leaves, and browned skin would make a lovely dinner party presentation. - Rebecca Vitale
Serves 2
- 2 duck breasts - mine were nice and fat from the farmers market - the size will of course affect the cook time
- 1/4 cup grade B pure maple syrup
- 1/2 teaspoon crushed red pepper
- zest from one orange
- 1 teaspoon fresh thyme
- salt and pepper
- Preheat the oven to 375. Score the skin of your duck in a criss-cross pattern, about a half inch apart, being careful not to cut through to the meat. Generously salt and pepper the duck all over.
- Heat an oven safe skillet just to medium. It is important not to get the heat too high, because you want to brown and crisp the skin and render most of the fat without burning the skin or overcooking the meat. An iron skillet is really best for this. I also give it a spritz of no-stick JUST to be safe.
- Put the duck breasts in skin side down. Once you start to see some fat rendering, move them around a bit. Check periodically - the skin should be slowly turning deep golden brown. As the fat renders you may want to remove some, you want about 1/8 - 1/4 inch of fat in the pan. Save that extra rendered fat for potatoes or something - it's magic!
- While the duck is browning mix together the syrup, zest, thyme and red pepper. Once your skin is brown and crispy and glorious, flip the duck over and spoon the syrup glaze over. Into the oven with it. After about 5 minutes, Re-lacquer the duck with the now fatty sticky wonderfulness in the pan, then back into the oven for about 5 more minutes (depending on the size of your ducks) - an internal temp of 125-130 is medium rare which is duck breast at its most delicious.
- Make sure to rest the duck for at least 5 minutes, 10 is better, before slicing.
- This recipe is a Community Pick!
- This recipe was entered in the contest for Your Best Maple Recipe
Comments (33) Questions (0)
2 months ago Kate Crawford
Delicious recipe. So tender, and the orange flavors really came through. Served this with Trader Jo's Brown Rice Medley made with Chicken broth base and Roasted Asparagus (cooked during resting time) with a few TBSPs remaining pan sauce drizzled over during cooking. Such a great meal!
3 months ago alidee06
This was delicious! Unfortunately when my husband cleaned the birds he cut the fat off (it was his first time hunting duck, he didn't know any better!) So I did my best to cook this without drying it out. It still came out deliciously and the sauce was especially good spooned over smashed sweet potatoes! Our first experience cooking duck was a great one thanks to this recipe!
12 months ago lovebeerlovefood
I could kiss you on the mouth. This is such a great recipe! We just made it for Easter dinner, and served with asparagus and carrots. It was phenomenal. Thanks for sharing!
12 months ago
Abbie is a trusted source on General Cooking.
Wow - high praise indeed - I am so glad you enjoyed it!!!
12 months ago chefpatty
I mean zested orange!
12 months ago chefpatty
Excellent. I segmented the zest end orange, squeezed the juice out of the pith and added it to the maple syrup mixture. At the end of cooking I added the orange segments to the sauce. While the duck rested, I sautéed escarole in a little of the duck fat and added some garlic. Fantastic together.
about 1 year ago Tashipluto
great and easy recipe! I subbed pomegranate molasses for the maple syrup, and ground cumin for the thyme -- worked out beautifully. thanks!
about 1 year ago
Abbie is a trusted source on General Cooking.
Oh that sounds delicious! I will have to try it!
about 1 year ago rayva
great recipe! subbed preserved lemon (Paula Wolfert recipe) for the orange zest and it worked well with its hints of moroccan spices. Thank you!
over 1 year ago QueenSashy
I absolutely must try this!
over 1 year ago
Abbie is a trusted source on General Cooking.
Oh I hope that you do, and that you enjoy it!
over 1 year ago Emalani
I'm making this tonight, so I probably won't have an answer by then - but just in case...aargesi, what do you serve with this duck recipe? I like Consultant's suggestion of Suspiciously Delicious Cabbage - then I might go with potatoes for the starch. But any other ideas? Thank you!
over 1 year ago
Abbie is a trusted source on General Cooking.
Hi there! I just saw this - what did you decide on? I would say go decadent and do duck fat potatoes:
and a salad. Probably don't want to eat that EVERY night but ...
over 1 year ago Emalani
We were going to do oven-roasted potatoes. I planned to parboil them a bit first but forgot about them (we have 9-month-old triplets who just learned to crawl!). They were a mushy mess when I found them again. I let them dry in the colander, and then fried the in the extra duck fat -- not as good as the duckfatfriedpotatoes, but good! The duck was DELICIOUS. Absolutely wonderful, thank you. And the cabbage was a pretty awesome side, too.
almost 2 years ago Consultant who cooks
I love this recipe! A few notes: I didn't have as much maple syrup as I thought, so I substituted honey for most of it and added a little splash of orange juice to make the glaze easier to spread. The 6 oz frozen duck breasts I bought were pretty thin and only needed about 6 minutes in the oven. I served it with fiveandspice's Suspiciously Delicious Cabbage for a great dinner.
almost 2 years ago
Abbie is a trusted source on General Cooking.
I love your twists! And am so glad you enjoyed them!
almost 2 years ago arielleclementine
hey congrats on the CP Abbie!! that picture is absolutely mouthwatering.
almost 2 years ago jenniebgood
I've been eyeing packaged duck breast at my local farmer's market for a few months now, but didn't want to get caught up in elaborate preparation - this looks so great and I'm going to give it a try. Congrats on getting chosen as a Community Pick!
almost 2 years ago
Abbie is a trusted source on General Cooking.
Thanks! Yes I recommend getting them at the farmer's market. Mine come with wings - a bonus for my stock bag!!!
almost 2 years ago gingerroot
Just now getting to this...and all I can say is LOVE!
almost 2 years ago Kitchen Butterfly
Oh, I miss my duck. Not a meat you find in Nigeria.....sniff sniff. This sounds so yummy.
almost 2 years ago
Abbie is a trusted source on General Cooking.
I am sad for you! No duck is no good :-(
about 1 year ago edgargonzalezcom
rise your own ducks!!
almost 2 years ago arielleclementine
love this!! quintessential aargersi. saved to make soon with duck from your fave purveyor!
almost 2 years ago
Abbie is a trusted source on General Cooking.
The guy at Barton Creek farmer's market has nice ones!!! He also has rabbits ...
almost 2 years ago healthierkitchen
Delicious! Just saved this for when I find the perfect duck breasts!
almost 2 years ago Midge
Yay for lacquered! Maple and duck do seem like they were made for each other.
almost 2 years ago LE BEC FIN
Perfect combo of some of my favorite things. Now, seriously, aa, when ARE you moving next door?
almost 2 years ago
Cynthia is a trusted source on Bread/Baking.
Duck & maple, great pair. You're seriously onto something here.
almost 2 years ago inpatskitchen
Lovin lacquered! Looks and sounds amazing! Saved!
almost 2 years ago
hardlikearmour is a trusted home cook.
Of course I love this! Yum to lacquered duck!
almost 2 years ago wssmom
Lacquered. Lacquered. Lacquered ... it does have a certain ring to it. Like your recipe. YUM. Love duck, don't make it at home nearly enough but this is an inspiration! Plus, I will get to say "lacquered" for the first time in, oh, months.
almost 2 years ago
Suzanne is a trusted source on General Cooking.
Perfect! the duck with maple, citrus and spice, amazing!!

subset: commoncrawl


text:
UNC Kenan-Flagler Earns Top 10 B-School Honors for Undergraduate Program
* Reuters is not responsible for the content in this press release.
For best results when printing this announcement, please click on the link below: http://pdf.reuters.com/pdfnews/pdfnews.asp?i=43059c3bf0e37541&u=urn:newsml:reuters.com:20130328:nPnDC85145 CHAPEL HILL, N.C., March 28, 2013 /PRNewswire-USNewswire/ -- Bloomberg Businessweek ranked the Undergraduate Business Program at the University of North Carolina Kenan-Flagler Business School as No. 10 in the United States for the second consecutive year. (Logo: http://photos.prnewswire.com/prnh/20121003/DC85432LOGO) The program was ranked No. 4 for public undergraduate programs, and No. 7 for student satisfaction. This year's detailed also earned grades of A+ for UNC Kenan-Flagler in three categories: teaching, job placement, and facilities and services. "Having our undergraduate business program recognized as among the very best in the country is gratifying," said James W. Dean Jr., dean of UNC Kenan-Flagler. "This ranking reflects the success of our program in providing our students the academic rigor combined with the leadership acumen to succeed in today's global business environment. Our advancement in the recruiter ranking reflects our students' ability to make a substantial impact in their companies. I am particularly pleased with our A+ rankings in teaching and job placement." To identify the top undergraduate programs, Bloomberg Businessweek uses a methodology of nine measures of student satisfaction, post-graduation outcomes and academic quality. These ratings follow the high marks from U.S. News & World Report, which ranked the UNC Kenan-Flagler program tied for No. 7 in a tie, based on its reputational survey of deans and program directors. For more information about the Undergraduate Business Program at UNC Kenan-Flagler, visit http://www.kenan-flagler.unc.edu/programs/undergraduate-business. The University of North Carolina Kenan-Flagler Business School Consistently ranked one of the world's best business schools, UNC Kenan-Flagler is known for its collaborative culture that stems from its core values: excellence, leadership, integrity, community and teamwork. Professors excel at both teaching and research, and demonstrate unparalleled dedication to students. Graduates are effective, principled leaders who have the technical and managerial skills to deliver results in the global business environment. UNC Kenan-Flagler offers a rich portfolio of programs and extraordinary real-life learning experiences: Undergraduate Business (BSBA), full-time MBA, Executive MBA Programs (Evening, Weekend and global OneMBA), online MBA@UNC, UNC-Tsinghua Dual-Degree EMBA, Master of Accounting, PhD, Executive Development, and UNC Business Essentials programs. It is home to the Frank Hawkins Kenan Institute of Private Enterprise. http://www.kenan-flagler.unc.edu/ SOURCE University of North Carolina Kenan-Flagler Business School
Comments (0)
This discussion is now closed. We welcome comments on our articles for a limited period after their publication.
- Ten countries scour sea for Malaysia jet lost in 'unprecedented mystery' |
- Confrontation in Ukraine as diplomacy stalls |
- Missing Malaysian jet may have disintegrated in mid-air: source |
- Mexico kills drug kingpin reported dead years ago: official
- Pistorius vomits in court at Steenkamp autopsy details |


text:
Dinah's Garden Hotel
Travel Blogs from Palo Alto
... didn't get any better... Fast track a few movies later, the man mountain sitting in front of me who couldn't sit still during the entire flight and reading The Lord of the rings I landed in LA. Now flying into Sydney is epic. LA sucked. You couldn't see anything. It was all clouded over and then when you could see something I suddenly wished I was above the clouds again. On the other hand flying into San Francisco on my transfer ...
Of Hip Hop Clothing outlets online
... you will certainly not have the ability to obtain the most effective rate for the clothing. They ought to be of high quality jeans and you need to have the ability to use them anywhere. You could as a matter of fact, have a full retail electrical outlet that operates just items for this society. These people have tons of truly terrific t-shirts with an assortment of attractive styles. These were nicknamed ...
... or so before sunset. Thankfully Adrian's tent went up easily and we were soon sitting down to a hot meal of ravioli, and planning the next day's trekking. We decided to head up Vernal Falls and this turned out to be a good choice. It's quite a short walk but includes about 200 steps and 300m of climbing. This walk is very popular with many of the 4 million park visitors each year so it is paved from the beginning of the ascent. But don't be fooled we saw many ...
Family, Friends, FUN & more FUN!
... to say good bye. Thank you Erin, Chris, Liam and Norah.
We love visiting you guys. We love you TONS!
My sister Cathleen and her family were in Ireland so we missed them! Love you guys. See you next time!!!!
VISTA, CA September 10- 14
My friend Rose lives in Vista. We have been friends for many years. Rose is a
dynamo. She is 20 yrs. older than I am and we look about the same age. She
takes excellent care of ...
Day 26: Take me out to the Ball Game
... or light rail as it is known here. This proved easier than I could imagine, with desks set up at the Embarcadero BART Station selling round-trip tickets at $4 each. This was a bargain, and involved none of the walking to a local station that Google had suggested.
We hoped on board, and were immediately surrounded by fans wearing the orange and black of the Giants. Everyone was excited, and didn't seem worried that the season was effectively over for the team. With a ...


text:
How and Why Star Wars: The Old Republic is Sinking Fast
Everyone knows that Star Wars: The Old Republic has been causing EA some serious problems lately. Many are calling it the TORtanic, and this is the fated maiden voyage. But let us explore how and why this game is failing so hard and fast.
Is the ship sinking?
Yes, yes it is. And there is quite a bit of solid evidence that people are abandoning ship. But what about those who say there is no problem?
It can't be denied that Star Wars: The Old Republic sold well. Estimates are ranging from between 1 million to 1.5 million sales. However these don't account fully for piracy. It was a major sales hit, but these games live on subscriptions. And subscriptions may be a problem for this game.
Picking an unsuitable engine
Star Wars: The Old Republic runs on the Hero Engine, developed by Simutronics. What is the problem? When Electronic Arts/Bioware licensed it, the engine was not working correctly. It is still not working correctly, and players are reporting everything from missing textures to targeting errors. One very amusing glitch was that you could not be properly targeted while dancing, although this was eventually patched.
Planning to fail and failing to plan
Greg Zeschuk is a man who has done some decent games, but they have been hit-or-miss. After the dreadful failure of Warhammer Online he moved on to other games, including The Old Republic. Gabe Amatangelo, who also worked on Warhammer Online, is in charge of PvP. So from the start we have some people who failed at their last MMO making a new one. This leads to their next problem.
Inaccurate reviews
It is an ugly secret that is often covered up, but the industry is prone to bias towards publishers. The previous link was about a reviewer fired for a truthful review. But something even more troubling is going on with The Old Republic. From the top of the industry to the bottom this game received inflated reviews that left out big problems.
Ausgamers gave it a 9.5, a 9.5 to a game which wasn't even released in Australia at the time. A game which was still not released in Australia at the time of this writing. A game they had no reason to even review other than that they wanted to. It's not hard to see why, with a huge EA logo and ad in their background at the time of this writing. Accurate reporting goes out the window when you are cashing paychecks from a publisher.
Continued on the next page


text:
Alta is a wonderful holiday destination because there are a variety of activities available during each season of the year. Although we may be famous for our world class snow conditions, there is also great rock climbing facilities in the area, which are suitable for all ages and skill levels. Utah Mountain Adventures are highly recommended for their climbing activities and they are known for their safe, professional and fun service. Read below for some more information on Alta mountain climbing. (more…)
Tagged under Alta Hotel
Summer is sadly ending, but the upcoming fall season is a beautiful time to experience Alta's amazing outdoors and explore some of the wonderful hiking trails in the area. There are dozens to choose from for a variety of skill levels and many are only a few minutes from our Alta resort. While taking a hike, you may also spot some of our local wildlife including moose, coyotes, deer, fox, eagles, and more.
No matter which season you decide to visit Alta, there are always plenty of great activities for both tourists and visitors alike! Come enjoy our vibrant local culture and see why so many people choose Alta as their favourite vacation destination. On Saturday September 8, the Alta Peruvian Lodge is hosting the exciting downhill dash at 4pm. Read below for more information on why you should attend this event!
During Alta's warmer climates, there's no better way to experience the great outdoors than to go mountain biking! There are plenty of great spots around and Alta is well known for its excellent biking conditions. Whether you are a beginner or a seasoned pro, there is a course for any skill level and you will experience a thrill like none other. You may even spot some of our unique wildlife in their natural habitat! Our Alta Lodge, the Alta Peruvian highly recommends mountain biking next time you visit for your Alta vacation. (more…)
Alta is a quaint resort town which is surrounded by beautiful scenery and world quality skiing conditions. This is a perfect vacation spot for lovers of the outdoors with wild life spotting, hiking, mountain biking and many more activities on offer. Our friendly Alta Peruvian Lodge staff can help you discover some excellent locations that only the locals know about and also help you find transport, but in the meantime here are five stunning reasons to visit Alta. (more…)
There are many great things to see in and around Alta, Utah and our Alta resort but one of the most amazing to visit, especially if you love the outdoors, is the Uinta-Wasatch-Cache National Forest, which covers most of Utah and parts of both Idaho and Wyoming. The forest is 2.1 million acres and is filled with stunning lakes, trees and views which will appeal to every outdoor enthusiast.
The forests name is derived from several different historic locations:
Uinta – The native word for "Pine Forest" or "Pine Tree"
Wasatch – An Ute Indian word meaning "low place in high mountains"
Cache – A French word referring to caves where trappers used to hide their furs
What to see near our Alta Resort: Highlights of the Uinta-Wasatch-Cache National Park
There are several beautiful recreation areas and wilderness areas within the parks grounds. While all of them are beautiful, we recommend visiting the Twin Peaks Wilderness Area, which can be found just to the East of Salt Lake City. Originally carved by glaciation and currently remodeled by erosion, this area consists of narrow canyons and high peaks (including Twin Peaks, Superior Peak, and Dromedary Peak) that combine to form a rugged and spectacular display. Much of the higher terrain is classified as alpine and characterized by large cirque basins and exposed rocky ridges.
If you're just looking for a stunning scenic drive, State Route 190 follows Big Cottonwood Creek along the northern boundary and separates this Wilderness from Mount Olympus Wilderness to the north. State Route 210 follows Little Cottonwood Creek along the southern boundary and stands between Twin Peaks and Lone Peak Wilderness to the south. The canyons of both these creeks are highly scenic, and you'll find trail heads along both routes.
What to do in Uinta-Wasatch-Cache National Park?
The park is known for its great hiking trails (although many are considered to be quite strenuous) and beautiful cycling routes as well as:
- Fishing in the lakes
- Climbing
- Picnic areas for day outings
- Nature viewing
- Hunting
And much more!
If you're looking for a great place to bring the family during your next trip to Utah, our Alta Resort, the Alta Peruvian Lodge, definitely recommends stopping by this stunning park. Whether you're interested in viewing the scenery, getting some exercise or looking into doing some hunting, fishing or horseback riding excursions, the park and the surrounding areas have everything that you're looking for. For more information on the park, visit the Uinta-Wasatch-Cache National Park website.
The summer is an extremely popular season for weddings in Alta, Utah, and even though our lodge may be closed to the general public, because of this we're able to offer some great options for couples hoping to hold their wedding in a beautiful, scenic mountain venue. Our picturesque location offers a stunning backdrop to your special day, and we've hosted many happy ceremonies on our grounds, with quite a few already book for the upcoming season! To help ensure that the outdoor grounds are dry enough for the best outdoor event possible, most of our weddings guests tend to book with us no earlier than the end of June, but we are open for events from May onward.
Weddings in Alta Utah – Services
Since our hotel is officially closed for the season starting in April, we're unable to offer lodging for you or your weddings guests. However, there are rooms available at the nearby Cliff Lodge allowing for you to spend a few days enjoying all that Alta, Utah has to offer in the summer.
As part of our Alta, Utah wedding package that includes a ceremony and reception at the lodge (available for a fee of $2,500.00) we can provide you with:
- Use of our dining room, the Alf Engen Meeting Room and our outdoor grounds
- Chairs and banquet tables as needed for both the ceremony and reception
- Full use of our public restrooms near the reception area
- Changing rooms for you and your guests
- Access to the lodge a few days prior to the event for you to set up decorations and furniture, as well as access to the lodge for a few days after the wedding for decoration and furniture take-down
- Access to the reception area and lodge for without a time-limit the evening of your reception. You can celebrate with your guests as late into the evening as you see fit!
Weddings in Alta Utah – Suggestions for the best Alta Wedding at Alta Peruvian Lodge
Without our regular hotel staff available, we cannot provide food or catering services, however, we can make our kitchens and spaces available to a catering company of your choice for food preparation and staging. To have the best wedding in Alta Utah possible, we suggest hiring a caterer who can provide the appropriate serving and bartending staff as well as their own dishes, silverware, linens, serving utensils, alcohol and can operate independently of a functioning kitchen. If that is an option for you, then our large kitchen-space offers the ideal staging location for your wedding banquet.
If you're interested in finding out how the Alta Peruvian Lodge can help you have the wedding of your dreams, call our hotel's General Manager, Todd Collins, at 801-742-3000. Todd can answer all of your questions about staging, what Alta, Utah wedding services we can provide as well as available dates for 2012.
Spring skiing is hugely popular in Alta and we have many great Alta events in the local ski areas as well as in town to keep you entertained during your spring skiing getaway!
Alta Events You Can't miss in March
March 13th – 17th – The Subaru World Freeskiing Championships are coming to Snowbird Ski Area and spectators are encouraged (a valid lift ticket and ski equipment is necessary to access the spectator area). This is sure to be one of the many Alta events put on that are not to be missed by ski enthusiasts. Stop by and check out the great skills of some of the world's best skiers and show your support.
March 17th – Join Steve Young, the former San Francisco 49er as well as a group of NFL athletes and Olympians for the Steve Young Celebrity Ski Classic on March 17th at Snowbird Ski Area, where they will be raising money for Wasatch Adaptive Sports programs. Presented by the Forever Young Foundation, Snowbird Ski Resort and American Airlines, this fundraiser is a great Alta event that combines the love of skiing with a good cause.
March 22nd – 23rd – If you're coming to Alta with your kids for some spring skiing, we highly recommend stopping by The Living Planet Aquarium for OffSpring Fling from March 22nd to 23rd an Alta event that's all about baby animals! With interactive activities, hands-on games, crafts and prizes, this is certain to be a fun day for your whole family and the event is free with public aquarium admission.
March 22nd – 25th – The 26th Annual ACE SnowFlake Festival & Chili Cookoff is being held from the 22nd to 25th of March this year, and will be four days of celebration all about the Town of Alta. One of our top Alta events, the festivities include:
- A kickoff dance party
- Mustache competition
- Snowshoe tours
- Games including: a gnome hunt, tug of war, fly casting contest, potato sack race and more
- Bingo night
- Annual chilli cookoff with prizes in both vegetarian and on-vegetarian categories
Where to stay for Alta Events – The Alta Peruvian Lodge
There are a lot of Alta events going on in March, and when you combine them with the great spring skiing we're expecting, how can you not book a trip to an Alta lodge today? If you're looking for a classic ski lodge with great amenities, why not try out the Alta Peruvian Lodge? We've been in Alta for over 60 years and we know exactly how to help you get the most out of your spring skiing trip.
Recently we've been inspired by a few posts circling the internet on Alta and the various accommodation choices available to visitors. Among those is the Alta Peruvian Lodge, our traditional ski lodge that has been an Alta landmark since 1948. We may be biased, but we think that there are a ton of great reasons to stay at our Alta lodge on during your next trip, and here are a few reasons why.
Why Stay at our Alta Lodge?
- 1. History and Charm. Our Alta lodge has been around for a long time, over 60 years in fact, and because of that, the Alta Peruvian Lodge has developed a unique character that's hard to find anywhere else. With a classic ski lodge vibe, combined with great "new-world" amenities, our lodge has everything you need to experience a ski vacation, the way it's meant to be.
- 2. We have everything you need for a fun vacation. From a games room and nightly movie to comfy common room and a great bar (for adult guests) we provide you with the means to create a fun, relaxing ski vacation for your entire group, regardless of age.
- 3. Perfect for relaxing. Looking to kick back after a long day on the slopes? Don't worry, we've got you covered. With our amazing outdoor pools and hot tubs (which overlook the mountain), sauna and cozy common rooms, we guarantee that you have everything you need to relax after a great day of skiing.
- 4. We feed you! Having your breakfast, lunch and dinner included in your stay (as well as après ski treats) isn't a common occurrence in the world of traditional ski lodges anymore, but luckily, the Alta Peruvian lodge as well as the other lodges in Alta have clung to the tradition of keeping our guests full and satisfied!
- 5. Great Staff (if we do say so ourselves). Our staff is made up of people who love to ski. That means that we have the passion, expertise and skills to help you get the most out of your trip to Alta. We've experienced it all when it comes to Alta, which makes us some of the best resources you can find and we want to share our knowledge with you.
- 6. In-house ski shop. Alta is known for its powder snow and having the right equipment is necessary to get the most out of your ski trip. Our in-house Alta Peruvian Lodge ski shop, is staffed with experienced skiers who know their gear and can help outfit effectively for our ski conditions.
Basically, we love skiing, we love Alta, and we think that if you like either or both of those things then you'll love staying at the Alta Peruvian Lodge. If you agree why not try our Alta Lodge for your next ski vacation?
Many people like to visit the Alta Peruvian Lodge and other Alta Hotels for the season's character our town has over the holidays. In February however, we get back down to what we know best, events specifically related to skiing and how you can improve your skills. This February we have a ton of great Alta events going on in the town and we hope that you're able to take time out of your busy schedules to come visit our Alta Lodge and experiencing them all!
Alta Events in February
February 4th – During weekends in February in the Alta Ski Area, they're holding Ski with a Ranger days one of their most popular Alta events where a highly trained volunteer from the Cottonwood Canyons Foundation will offer kids a fun learning experience on a groomed run while discussing local history, the environment and winter ecology. The event runs on Saturdays and Sundays at 1:30 pm and meets at the bottom of the Cecret Chairlift.
February 14th – What would February be without some great Valentine's Day Alta events? On Tuesday February 14th at Our Lady of the Snows there will be a wine, chocolate and cheese tasting starting at 7pm. The event runs till 9:30 and is put on by the Alta Community Enrichment program and costs $15.00. The even requires pre-registration so if you're coming to town with you sweetheart this Valentine's day why not book early to make sure you can take part in this fun Alta event?
February 18th – 24th – Teen Freeride Camps are on during President's Week in the Alta Ski Area. The camps are for teens aged 13-17 and help them improve their skills and get a better understanding of Alta's great ski conditions. Skiers are not asked to commit to a certain number of days, making this Alta event perfect for vacationers. Check-in is at 8:30 am in the Ski Adventure Center and the camp runs till 4:30. The event cots $120 a day and includes lunch (doesn't include lift tickets).
February 24th – 25th – The Telluride Mountainfilm Tour is coming to Alta this February. This informative event which is held at Our Lady of the Snows at 5:30pm on the 24th and 25th costs $5.00 per night and showcases some of the best films of the year from the Telluride MountainFilm Fest. Tickets are available at the door, and since you're able to bring your own food, why not make a family picnic night out of it?
We still have Alta accommodations available for February but we're filling up fast, so make sure you book quickly and don't miss out on any of these great events.


text:
My Account (sign in)
lowest rate guarantee
97 Pangkham Road
Five great reasons to book with us!
Over 390,000 hotels worldwide – more added every day
Trusted by over 7,000,000 satisfied customers
Best Price Guarantee
4 million+ hotel reviews by agoda customers
With availability in over 37,000 cities worldwide
agoda special offers
including last minute offers(even same day!)free nightsfree upgrades!
Customer Support
Super Dim Sum deal, top notch not...
0.17 Km.
Close to my workshop/meeting site....
0.19 Km.
Loved the courtyard, like the fact...
0.21 Km.
0.23 Km.
Clean room,vintage design,comfort...
0.26 Km.
Excellent staff, very lovely...
0.38 Km.
0.4 Km.
0.5 Km.
0.62 Km.
Cleanliness, easy to access,...
0.63 Km.
Centrally-located, fast check-in...
0.65 Km.
A reasonable price,clean room with...
0.67 Km.
Value for money, Clean, Good...
0.69 Km.
0.73 Km.
nigth club and karaoke outside,...
0.74 Km.
breakfast, big room and friendly...
0.79 Km.
Close to Morning market, close to...
0.8 Km.
Big well equipped room, good size...
0.82 Km.
Close to shopping, restaurants,...
0.84 Km.
4.5 / 5
over 41,900 reviews
of users recommend us
Go To Top
All material herein © 2005 – 2014 Agoda Company Pte. Ltd., All Rights Reserved. AGODA ® is a registered trademark of AGIP LLC, used under license by Agoda Company Pte. Ltd. Agoda is part of (NASDAQ:PCLN)


text:
I got a call at work and this was the conversation (nearly word-for-word): (I pick up the phone) Chris: "Hello, this is Chris Taylor." Maureen (in a very high-pitched, happy voice): "Hi, this is Maureen. I just took over in this sales position at PC Connection. You placed an order with us?" Chris: "Yes, I [...]
That feeling
Jan 11, '02
You go to bed four hours earlier than everyone else you know. You wake up five hours earlier. You stand under a hot shower and let the steam slowly engulf you. You rub the sleep from your eyes and stifle a yawn. A few minutes spent to feed your starving body. You take a deep [...]
Jan 11, '02
Yesterday I passed a truck for a plumbing company called, "Royal Flush." A few weeks ago I passed a truck for a construction company called, "Erection Specialists."


text:
Top Posts & Pages
- How to Optimize User Experience Across Multiple Devices
- Retail is not dying… just transforming.
- peHUB » Doug Kilponen, Ben Smith: First They Ignore You, Then They Want To Buy You: Managing The Startup-Big Company Relationship
- Why Brick & Mortar Retailers Will Live Forever
- Amazon's Hidden Weak Spot: Lack Of Local Leverage | Forbes
I advise, found, and invest in new media and technology companiesTweets
- RT @FindnSave: We're giving away #free collapsable shopping bags and tshirts at 12:15 on 4th/Trinity at #SXSW http://t.co/2Yh9GthfNn 8 hours ago
- Cash allows persistence t.imehop.com/1kENv9k http://t.co/NIytaEhjKK 1 day ago
- RT @socialwire: "I love our weekly calls with @socialwire because you're the only one that's making us money," said one of our clients. 1 day ago
- RT @agoldfisher: No. 1 post on @pehub this week is on how @BlendApp raised seed end and refuses service to @OhioState students. http://t.co… 2 days ago
- RT @jslavet: A big congrats to @StevenBoal and the entire @coupons team on today's successful IPO ow.ly/umopT 2 days ago
Recent Posts
Stuff I post about
A.T.Kearney advertising alabama amazon Associated Press Behavior Ben T Smith IV blog borland Brick and mortar business business metrics Carnegie Mellon CEO CodeGear Consumer davin deal and no deal deals Discovery shopping Disney east coast ecommerce facebook find&save Find n Save Fishing funding game show network google GSD harsh realities hot startups internet startups investment iphone Lee Enterprises local maples Mass media McClatchy Company MediaNews Group merchantcircle Mergers mobile Mobile Devices Newspaper newspaper ads newspapers oliver muoto Online advertising Online Shopping plaxo relationships Retail Retailers Risk rustic canyon shopping silicon valley Smartphone social-media Spoke Software Startups tablet Tablets technology venture capitalists venture firm video Wanderful Media Washington Post web entreprenuer Yahoo zibibbo
Tag Archives: Mark Pincus
Ben Smith, Mark Boslet: Career Building Like A Startup: Thoughts On Reid Hoffman's "The Start-up of You"
In the 40 years since the publication of What Color Is Your Parachute, the job market has collapsed, collapsed again and changed almost unrecognizably. The time has come for a new job hunter's bible. Our vote goes to Reid Hoffman's … Continue reading
Posted in A.T. Kearney, Deals, Personal, Relationships, Silicon Valley, Spoke Software
Tagged A.T.Kearney, Carnegie Mellon, LinkedIn, Mark Pincus, McKinsey & Company, merchantcircle, relationships, Risk, Startups, Tepper, UC Davis


text:
President Barack Obama mourned the deaths of 31 U.S. special operations troops in a helicopter crash in Afghanistan.
He said it's a reminder of the "extraordinary sacrifices" being made by America's military and its families.
An American official said the helicopter appears to have been shot down on Saturday in eastern Afghanistan in the deadliest single combat incident of the decade-long war.
Mr. Obama learned of the deaths while at Camp David. In a written statement, he said Americans' thoughts and prayers go out to the families of those who perished. He also mourned the loss of seven Afghan soldiers killed in the crash.
Keywords: NATO troops in Afghanistan, Afghan war, Taliban
Obama discusses helicopter crash with commanders
Taliban who downed U.S. chopper killed
Afghan insurgents shoot down helicopter, kill 30 U.S. troops
More In: International | News


text:
Use of Force by US Cannot Solve Problems - Russia
Russian Foreign Minister Sergei Lavrov
© RIA Novosti. Vladimir AstapkovichRelated News
MOSCOW, December 1 (RIA Novosti) - Resolving world problems by force as the US is trying to do does not work, Russian Foreign Minister Sergei Lavrov said on Saturday in an opening speech to the 20th session of the Foreign and Defense Policy Council.
"The line of conducting democracy by iron and blood does not work," Lavrov said. This is clear in the case of Iraq and other states, he added.
"No-one knows in the end what will happen in the Middle East," including Syria, he said.
Lavrov recalled the fate of previous attempts to use force by circumventing the UN Security Council, and expressed anxiety that some states were trying to make the "Libyan model a precedent."
Speaking about the future world order, Lavrov said "in future, not all rules which are used in world politics now, will exist in future."
"We can expect that in the next 20 years, the world order will be more complex," he added.
Add to blog
You may place this material on your blog by copying the link.
Publication code:
Send by e-mail
Leave a comment
Most read
Top multimedia
Image Galleries: Yury Gagarin: Life of the First Man in Space in Pictures
Video: Yury Gagarin's International Fame
Infographics: Sledge Hockey


text:
Home - Destinations - iPhone/Android - Partners - Forum - Photos - Deals - What's New |
Know the location of this area? Show us! We
don't know it, but we're working on cool new features that need it!
DescriptionAn interesting mix of single pitch trad and sport routes on a relatively small, steep outcropping. The rock is gneiss (typical of this area), so be prepared to confront lichenous, sometimes insubstantial rock in places. Most of the routes are on the colorful north face, receive little sun and offer an escape from a hot day. Two recently installed sets of top anchors allow quick raps from all routes. "What's My Line" (10b), a challenging trad lead up a series of thin interconnected cracks, will keep you in suspense. "Atmospheric Testing" (10+ sport) will definitely expose you to the rarified air. Getting ThereTake CO Highway 7 south from Estes Park for 6 miles, turn off at Lily Lake Visitor Center. Park at the Twin Sister's Trailhead (the 'north' approach) and take the trail for 3 switchbacks (important!). Find a faint trail going uphill and follow it, or its general direction until you find the expansive talus slopes underlying The Crags. Mountain goat your way up the talus to the first huge face, The Lower Great Face, and find Castaway Crag at its lower left end (facing the rock). Be forewarned, this is at least a 45 minute uphill thrutch and will cost at least a liter of sweat. 5 Total Routes
The ClassicsMountain Project's determination of some of the classic, most popular, highest rated routes for Castaway Crag:
Featured Route For Castaway Crag
Air Conditioning 5.7 5a 15 V+ MVS 4b CO : Estes Park Valley : ... : Castaway Crag
This lies on the left of What's My Line on the left side of this little crag, a satellite crag on the left side of the Lower Great Face. It ascends the obvious crack with an alpine feel in a subalpine environment. Start on the left-facing flake. Move up into a pod. Go left and jam/stem up the steep-for-5.7 crack with great holds. Power through a brief bulge. Fire for the top. No fixed pro. Enjoy. You could continue up to the left edge of the Lower Great Face or rappel.There...[more] Browse More Classics in CO
News and Events For Castaway Crag
Latest Regional Forum Messages
From Colorado & Rocky Mountain Region Go to Forum | What's New | Post New Topic


text:
I will certainly use animed direct again and again, they are a top notch company. Many thanks for speedy delivery of my order .
Great customer service, outstanding products and staff that are extremely clued up on all aspects, an overall enjoyable experience. Will buy from guitarguitar again and again.
Connect with Facebook to get one click access to Trustpilot. It's easier.
Sign up with Facebook


text:
December 23, 2013 - Industry News
AAA projects 94.5 million Americans will journey 50 miles or more from home during the year-end holiday season, an increase of 0.6% from the 94 million people who traveled last year. This upward trend marks the fifth consecutive year of increases and the highest travel volume recorded for the season
Tags: AAA, Highways, Holiday Driving
August 22, 2013 - Industry News
According to a new survey from AAA, Americans are less likely than they used to be to perceive a serious threat from dangerous driving behaviors such as drunk, aggressive or drowsy driving.
Tags: Drivers, AAA, Distracted Driving, Safety & Compliance
July 1, 2013 - Industry News
As Americans celebrate Independence Day, the highways are forecast to be a little less crowded than they were a year ago.
Tags: AAA, Traffic Congestion, Highways
February 13, 2013 - Industry News
A new report released by the American Trucking Associations summarizes the car-truck relative contribution/fault findings of several large-scale studies.
Tags: FMCSA, AAA, ATA, CSA, NHTSA
The Intelligent Transportation Society of America along with major automakers, safety advocates and transportation officials from across the country, are joining together to urge the Federal Communications Commission to protect the 5.9 GHz band of spectrum.
Tags: AAA, AASHTO, CVSA, FCC
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
The expert, Mark Betner from Citgo will answer your questions Ask a question
Wheel end expert Jeff Geist from STEMCO will answer your questions Ask a question
VIDEO: Meijer's Clean Diesel Fleet
Ultimate Test Drive Video: Find Out What's Revolutionary About the Mack Twin Y Suspension
Love's Marks 50 Years by Giving Back to Community
Trucker Group Criticizes Fuel Economy Rules, Others Positive to Cautious
Dometic Launches Blizzard Battery-Operated Air Conditioner for Trucks
Noregon Offers Multi-Makes Diagnostic System, Modules for Volvo, Mack
Philips Releases Windshield Treatment Kit
2015 Sprinter Receives 4x4 System


text:
Pernem Pedne / पेडणें Perném |
City | |
Coordinates: 15°43′01″N 73°47′52″E / 15.71694°N 73.79778°ECoordinates: 15°43′01″N 73°47′52″E / 15.71694°N 73.79778°E | |
Country | India |
State | Goa |
District | North Goa |
Sub-district | Pernem |
Elevation | 47 m (154 ft) |
Population (2001) | |
• Total | 5,285 |
Time zone | IST (UTC+5:30) |
Area code(s) | 0832 |
Vehicle registration | GA 11 |
Pernem (pronounced [pɛːɽɳɛ̃ː]) is a city and a municipal council in North Goa district in the Indian state of Goa.
Pernem is located at 15°43′01″N 73°47′52″E / 15.71694°N 73.79778°E at an average elevation of 47 metres (154 ft).[1] Pernem is one of the twelve talukas of Goa. Pernem taluka consists of twenty village panchayats and one municipality (Pernem city). Pernem taluka is surrounded by Vengurla and Sawantwadi talukas of Sindhudurga to the north, Dodamarg taluka of Sindhudurga to the east, Bardez and Bicholim to the south and the Arabian sea to the west.
There is no major source of income in the taluka. The taluka market does not attract too many people from around the area. Most of the people depend on other regions for employment. Pernem consists of around 200 small enterprises. Thursday weekly market is exceptional, which is the second largest in North Goa.
Viscount of Pernem High School, Shree Bhagwati High School and St Joseph High school are 3 high schools, 1 Govt Higher Secondary, 1 Govt college of arts and commerce and 1 ITI. For higher education in Science, Engineering and Medicine students have to go to other cities.
As of the 2001 India census[update],[2] Pernem had a population of 5,285. Males constitute 52% of the population and females 48%. Pernem has an average literacy rate of 74%, higher than the national average of 59.5%: male literacy is 79% and female literacy is 70%. In Pernem, 10% of the population is under 6 years of age.
Religious festivals[edit]
Pernem is famous for Dussehra. On the day of Kojarari Pournima a big feast is organised. People from Maharashtra, Goa and Karanataka visit Pernem . People visit temples like Adisthan Mangar, Bhagawati, Rawalnath, Sateri, Dwarpal, Mauli, Gautameshwar, Narayan, Mulvir, Maruti and Shri Nagnath. This is one of the biggest feasts of Goa.
Water Falls[edit]
There are two waterfalls in Pernem. one, in Mauli Temple area at Sarmale and another at Mulvir Temple area at Malpe.
Pernem is well connected by road and the Konkan railway. Pernem railway station is the first railway station in Goa for inbound trains from Mumbai. Mandovi Express, Konkan Kanya Express and Goa Sampark Kranti Express halt here. National Highway 17 passes through this area which connects it to Bombay and Mangalore.
- ^ Falling Rain Genomics, Inc - Pernem
- ^ "Census of India 2001: Data from the 2001 Census, including cities, villages and towns (Provisional)". Census Commission of India. Archived from the original on 2004-06-16. Retrieved 2008-11-01.


text:
1958 Oldsmobile 98 4dr with 8,227 original miles. Stored the last 32 years. This is an incredible original car with all original paint, interior,... More
1959 Oldsmobile 98 ConvertibleTo be OFFERED AT AUCTION. ... More
1957 Oldsmobile 98 ConvertibleTo be OFFERED AT AUCTION. ... More
1958 Oldsmobile 98 Holiday CoupeTo be OFFERED AT AUCTION. WITHOUT RESERVE... More
1960 Oldsmobile 98 Holiday ScenicoupeTo be OFFERED AT AUCTION. WITHOUT RESERVENothing can match the feeling of freedom as taking a long road trip... More
1957 Oldsmobile 98 Deluxe Holiday Coupe The flagship of the Oldsmobile division of General Motors, the "98" would remain the bread and butter of the... More
1954 Oldsmobile Deluxe Holiday Coupe Just 40,544 Original Miles! Just 2 owners from new! Highly Original Interior! Stunning and Rare Black/White on Red Color Combination! Original Colors! Recent Cosmetic Restoration! Matching... More
1963 Oldsmobile 98 Convertible, automatic, power windows & roof. Refurbished interior; needs paint, light body work, and new top. 2 owners, original paperwork. Garaged... More
s#666A knock out 1967 Oldsmobile 98 convertible. Powered by a 455 with and automatic transmition, power steering, power brakes, air conditioning, the list goes... More
1950 Oldsmobile Rocket 98 Futuramic 4 Door (Holiday Deluxe?) Sedan, 122" wb Rocket V8 303 ci/ 135 HP 2brl engine Original Family Owned, third generation, garaged. First... More
8,194 ORIGINAL MILES This stunning 1980 Oldsmobile 98 Regency has traveled only 8,194 miles since leaving the showroom in 1980. If you're looking for an... More
1968 Oldsmobile 98 Convertible. Three owners, 95,000 miles. Lacquer re-spray in original color and re-chromed bumpers. New Michelin radials. Original with exception of wear... More
1956 Oldsmobile 98 4-DR. HARDTOP, Exceptional 1956 Olds 98 4 dr HT, second owner - always garaged, 37,000 original miles. Exterior repainted and in excellent... More
Low production Rare color combination This Olds 98 convertible is in outstanding condition and it's loaded with options including factory air conditioning. Only 3,769 built. It... More
This is a very special 1962 Olds Ninety-Eight 2door hardtop. It is an absolutely beautiful car to say the least but it doesn't end there. This Ninety-Eight... More


text:
This Group is for Martial Artist who want to talk about Martial Arts, Share you Thoughts, Tips, and Expertise.
Website: http://38947b-8-8jitd9ojnq565qife.hop.clickbank.net
Location: Any Where.
Members: 8
Latest Activity: Apr 28, 2013
Looking for the best in roofing? Look no more and just call for Bedford Roofing. Roofing Bedford TX
Started by Shanelle Wintercrest Jul 11, 2011.
Dear ALL,Good Day ! If you're interested in my network, I'm giving away a Global Horizon website (term & conditions applied) pls checkout this site…Continue
Started by Felix Feb 12, 2011.
Stay safe!Do whatever it takes to keep yourself, your friends,and your loved ones out of danger.Do whatever it takes ...even if that means avoiding a fight!To paraphrase my teacher who paraphrased…Continue
Started by James McDonald Jan 26, 2011.
© 2014 Created by Home Based Business Program. Powered by


text:
"Definitely an "A " grade"Reviewed by al g of "NJ" on Jun 2, 2011
It was a great experience being at this aparthotel, friendly staff and very convenient location. I definitely recommend it Al.
""Reviewed by a Hotels.com guest on Jul 16, 2010
The hotel was very central and colse to the beach and all other services. The hotel staff are excellent and very helpful with buckets of information for the traveller. Nice small hotel and ideal for couples without children who like a quiet hotel. As their is no pool this is a help to keep the hotel peaceful too. Best to have a room at he back of the hotel as the Kathedral niteclub is in front of the hotel. Overall good value and very central. ie. no taxi costs.
Star Rating
Accommodation Types
All rates are per double room per night and exclude taxes and fees. They are subject to availability.


text:
30 Viswaroopam Articles
Kamal Haasan has not spoken to Rajinikanth for film
2 years ago 0After the buzz about Tamil superstar Kamal Haasan reviving his film Marudhanayagam with rival Rajinikanth as part of the cast, there's a denial from… Read Article ▶
Rahul Bose plays a baddie in Kamal Haasan's 'Vishwaroopam'
2 years ago 0Rahul Bose is kicked about doing a villainous role again in his career Rahul Bose was last seen in a villainous role in Thakshak in 1999 and after… Read Article ▶
Kamal Haasan: I stopped working for money 25 yrs back
2 years ago 2Kamal Haasan decided to helm Hindi-Tamil bilingual Viswaroopam, which will have a backdrop of US, Britain and Jordan, because he doesn't believe in… Read Article ▶
Move over Bollywood, south rules Indian entertainment
2 years ago 1The four southern states together account for more than half of India's 10,000 movie screens Bollywood may hog the limelight but the quiet and… Read Article ▶
Kamal Haasan's 'Viswaroopam' finally has a heroine!
2 years ago 1Miss India USA and VJ Pooja Kumar replaces Sonakshi Sinha as the leading lady of Kamal Haasan The search for the female lead for Kamal Haasan… Read Article ▶
Happy birthday, Kamal Haasan!
2 years ago 9He is a legend and a star with talents galore. Kamal Haasan was born into Tamil films but is a household name in Hindi, Malayalam and the Telugu film… Read Article ▶
More Viswaroopam


text:
Download Preview | Edit or add effects |
by vectomart, Stock Photo 25625414
art, atlas, background, button, call, city, clip, colorful, concept, country, destination, flag, fuel, geography, gps, graphic, home, icon, illustration, journey, land, locate, location, macro, map, mapping, mark, navigate, needle, petrol, pin, pinpoint, place, pointing, pump, push, pushpin, restaurant, road, roadmap, service, set, shiny, space, symbol, town, travel, trip, vector, web
Made with love in NYC.
Bigstock and Big Stock Photo are registered trademarks of Shutterstock. Bigstockphoto is a trademark of Shutterstock.
© 2004-2014 All rights reserved - Bigstock®


text:
How was it working in Rio? How was that experience shooting in that real of an environment that's a substitute for Brazil?
Elsa Pataky: I've been in Brazil and when I get to set I was really impressed because you have that same type of vibe, like small houses and the way they were living. It was really poor people so the way they were living it was really depressing. And for me it was really important because she (her character) lives there. Even though she's a cop, she part of that. So being there, watching that gives me the impression of how her life is and why she's fighting for and what she's fighting.
So you're sort of a temporary partner with Dwayne Johnson's character. Do you guys get along? Do you like each other?
Elsa Pataky: Oh, ya. Ya. I love him. Working with him has been great. He's really professional, his sense of humor, he always has a joke for everything. So we were laughing a lot. And it's funny because he's also such a big guy playing this tough guy also and she's trying to be a tough woman because she's the only girl and she's around all these SWAT guys so she's always trying to make sure her job is correct. Trying to impress him all the time so it was funny because we were always joking like, "Don't touch me, woman!" things like that. We were playing. Both of us we have scenes where we are shooting. We are partners. So I think it was important to have a good relation with him. Because in the beginning in the movie it's a little tense because she thinks she's in a men's world kind of and this guy gets her because she's good looking or just a girl. But I'm gonna show him I'm more than a smile. That I know my job. That I know what I'm doing. But he says to me, "I know your husband has been killed and you're maybe the only police officer that's not corrupt." So that moment is the fight between them, the first time they see each other. But at the end they become friends and understand each other. But completely opposite when I met Dwayne we were already laughing together and making jokes about each other and he has a great smile of course and when he uses it it's amazing so, it's been great. I really like working with him. I hope I get to work with him again because you expect maybe he's gonna be so serious, you know the tough guy like him and Vin, but he has this mood and there's laughter like when we're in the makeup trailer or something and...
Someone's got a crush on Dwayne...
Elsa Pataky: [Laughs] Both of them! I mean...no! I like him very much but I can say the same about Vin. They're very different characters in the movie but characters in their real life are completely different.
Who jokes around more?
Elsa Pataky: Uh, with me. Both of them. I know Vin is more serious because when he's shooting he's very focused so when he's shooting he doesn't joke around. And Dwayne does. He always has a joke, a line to make you laugh and Vin is more serious, but away from that he's amazing. He really...sometimes when you do action movies you think that the characters or the way you prepare the character is more superficial or it's not as deep as doing a drama which I don't agree because being a tough good hero, it's not easy. And you can see how Vin, he knows what he's doing. And we have very special moments, the both of us, we're not just together all the time, the chemistry has to be there you know.


text:
Sign In
Gift Cards
Order Status
My Account
Wish List
View Cart (0)
Apple Clafoutis
Apple Clafoutis
Clafoutis is a French dish that is a cross between flan and a pancake. It is hearty enough for breakfast and versatile as a dessert that never fails to impress.
Yield: 8
Cook Time: 1 hour
4 large, slightly tart apples, like Pink Lady or Braeburn (2 to 2 1/4 pounds)
1 tablespoon fresh lemon juice
2 tablespoons unsalted butter
2 tablespoons light brown sugar, preferably organic
1/2 teaspoon cinnamon
3 eggs
1/2 vanilla bean, split, or 1/2 teaspoon vanilla extract
1/3 cup sugar, preferably organic fair-trade sugar
Pinch of salt
2/3 cup sifted unbleached all-purpose flour
1/2 cup plain yogurt
3/4 cup low-fat milk
Preheat the oven to 375 degrees. Butter a 10- or 10 1/2-inch ceramic tart pan, baking dish or clafoutis dish.
Peel, core and slice the apples into 16ths. Toss with the lemon juice in a large bowl.
Heat the butter in a large, heavy skillet over medium-high heat. Add the apples to the skillet. Cook, stirring, until they begin to look translucent, about 4 minutes. Add the brown sugar and cinnamon. Stir together until the apples have softened slightly and begun to caramelize, six to 8 minutes. Remove from the heat, and transfer to the baking dish.
In a large bowl, whisk the eggs with the seeds from the vanilla bean or the vanilla extract. Add the sugar and salt, and whisk together. Slowly beat in the flour, then add the yogurt and milk. Whisk until thoroughly blended. Pour over the apples in the baking dish.
Place in the oven, and bake 35 to 40 minutes until the top is browned and the clafoutis is firm and puffed. Check by pressing lightly on the middle. Remove from the oven and cool on a rack, or serve warm.
Serve With:
Chateau Tour de Farges Muscat de Lunel (375ml)
share page
Contact Us
Live Chat
Privacy Policy
Customer Service
(877) 698-6841
© The New York Times Company and © Global Wine Company, Inc. NYT Wine has chosen Global Wine Company and its panel of experts to select the wines and operate the club on our behalf. The Wine Club is operated without the participation of the Times wine critics or other members of the newsroom. State laws prohibits the offer of free goods in conjunction with the sale of alcoholic beverages. The cost of all items in an offer is included in the advertised price. All wine sales are made by a licensed retailer in compliance with state laws and the licensed retailer assures all involved that it fully complies with all states laws applicable to it. All credit card payments will be facilitated by Global Wine Company, Inc., located at 1401 Los Gamos Dr. #230, San Rafael, CA 94903, with the exception of orders shipped to Texas, which will be sold by Texas licensed winery, Landon Winery, located at 2508 Lee Street, Greenville, TX, 75401, Phone: 1-903-454-7878. Due to state laws, wine can be purchased only by adults 21 years and older. See
shipping policy
for states served.