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San Antonio says they are not trading Tony Parker, but the Knicks are still interested
May 12, 2010, 12:27 PM EDT
RC Buford says he wants to keep Tony Parker in San Antonio. He should — elite point guards at the peak of their game are hard to find. But if San Antonio can't convince Tiago Splitter to come to the states from Europe, the Spurs will have to consider trading Parker, they don't have other…
NBA Playoffs: Ray Allen steadily increasing his free agent value
May 12, 2010, 12:06 PM EDT
Let's keep it simple, for starters: Ray Allen is old. Soon to be 35-years-old, in fact. That means that when Allen enters free agency this summer, a number of teams will see him as a bit too much the elder statesman to be part of their rebuilding projects, and a few quasi-contenders may also take…
LeBron James had a rough Tuesday night. He shot 3-of-14 from the field as his team struggled to escape from under the heel of the Boston Celtics. Cleveland lost by 32 points on their home court, and when that happens to the best team in the league (record-wise, at least) boasting the best player in…
NBA Playoffs Celtics Cavs Game 5: Let's not overlook the return of the Celtics' horsemen
May 12, 2010, 11:14 AM EDT
I understand the reaction. I had the same. Shock. Disappointment. Disbelief. It's not about who you root for. LeBron James performing at a high level? It's good for the NBA. It's good for the playoffs. It's good for the sport. And his monumental failure last night left a lot of basketball fans feeling betrayed, and…
Last night was perplexing. LeBron James was almost an afterthought in the Cavs offense. He missed some early jumpers, but rather than adjust and drive the lane (something he does better than anyone in the league) he was just floating around on the weakside, He was not aggressive and seemed disinterested. Was it the elbow?…
Any place that dots can be connected around LeBron James, they will be. Even a few places they can't people will try. So when popular Kentucky coach John Calipari had courtside seats for the Cavaliers/Celtics Game 5, lines started being drawn. We turn it over to Yahoo Sports college hoops blog The Dagger: One week…
Maybe he's gone anyway. Who knows? If LeBron James has done one thing well it's create an air of mystery and suspense around his off-season decision. Through it all, the conventional wisdom has been that if the Cleveland Cavaliers win the NBA title this year, he stays. However, if the Cavs melted down much earlier…
Robin Lopez will return for Phoenix Suns in Game 1 against Lakers
May 12, 2010, 8:54 AM EDT
Phoenix is going to need a little more size to match up with the Lakers — Louis Amundson, Channing Frye and Jared Dudley have played well and very hard so far, but the Lakers front line presents an entirely new level of challenge. Welcome back Robin Lopez. The big physical, defensive anchor for the Suns…
Joe Johnson did not overwhelm in the playoffs — Atlanta relied too much on "iso-Joe" offense and not on ball or player movement. That allowed the Buck to stay close and the Magic to just blow them out. The conventional wisdom now is that the Hawks are going to let Johnson walk. He's savvy enough…
NBA Playoffs Celtics Cavs Game 5: Celtics dominate as LeBron James fails in the big time
May 11, 2010, 10:05 PM EDT
If it's true that the sports Gods hate the city of Cleveland, Ohio, tonight was an especially delectable act of maliciousness by the deities. The Boston Celtics walked into Cleveland, dragged the Cleveland Cavaliers outside, and executed them as if they were a lottery team, 120-88. LeBron James had 15 points on only 3 of…
Mark Cuban says not to worry about Mavericks finances, or Ross Perot Jr.
May 11, 2010, 9:45 PM EDT
You knew Mark Cuban was not going to stay quiet. Ross Perot Jr. (not him, but his son), a minority owner of the team, has filed a lawsuit saying Dallas Basketball Ltd., the business that runs Mavericks, is "insolvent and and/or in imminent danger of insolvency." Cuban responded to the Dallas Business Journal and said…
Tim Donaghy makes wildest claim yet, crosses about eight lines of decency
May 11, 2010, 6:34 PM EDT
Tim Donaghy has no credibility. In addition to the fact he is a disgraced referee with a gambling problem who spent time in jail for his crimes, reasonable studies looking into his claims — people that broke down the numbers — showed he was full of crap. The claims he made turn out to be…
It's finally official, Mikhail Prokhorov owns the New Jersey Nets
May 11, 2010, 6:04 PM EDT
It's the dream of fans of so many struggling NBA teams — start the rebuilding plan by getting a new owner. An insanely rich one willing to spend. In New Jersey, step one is complete — the NBA Board of Governors has approved Russian billionaire Mikhail Prokhorov as the owner of the New Jersey Nets.…
Is the sale of the Hornets stuck? Nah, probably just David Stern trying to speed it up.
May 11, 2010, 5:35 PM EDT
UPDATE: 5:35 pm: Hornets president Hugh Webber said that the ownership transition will be completed soon. A statement via Mark Spears at Yahoo. "Goal of both parties is still to finalize all the legalities and announce a deal sooner than later… Day to day execution of plans including the search for a head coach has…
LeBron Biographer Buzz Bissinger says he is gone from Cleveland, title or not
May 11, 2010, 4:42 PM EDT
Before we get into this story, let us bask in the glory of Buzz Bissinger being interviewed by one blog, then that story being reported on another blog. Oh, the cruelty. Oh, the journalistic dishonesty. On to our story. Bissinger has a book to sell, LeBron's Dream Team, the book he co-authored with James about…
According to Ross Siler of the Salt Lake Tribune, Deron Williams has been told to rest his injured wrist this off-season, and Williams hopes the injury will not require surgery. If Williams does end up getting surgery on the wrist, he will likely miss the World Championships this summer. Williams completely dominated the Jazz's first-round…
NBA Playoffs, Cavaliers Celtics Game 5: Rajon Rondo is going to think this is a hockey game
May 11, 2010, 2:51 PM EDT
We don't know much about what the Cleveland Cavaliers have planned to stop the Rajon Rondo layup parade — none of their key players have spoken to the media for a couple days. Mike Brown has chosen not to tell the national media the details of his plans. Smart man. But we can infer, from…
Wesley Matthews is going to get paid by somebody, but will it be the Jazz?
May 11, 2010, 2:14 PM EDT
Life's not all that easy for undrafted players in the NBA, who typically have to fight and claw just to find a place on a roster. That wasn't the case for Wesley Matthews, who was fortunate enough to be signed by the Jazz after spending four years playing for Marquette. It didn't take a trip…
Dr. J was graceful. The game in the 1970s into the 1980s was evolving, Magic was just bringing Showtime and up tempo to the sport. It was moving from grinding toward beautiful (despite a setback in the 1990s). Guys were really just starting to play above the rim consistently (there had been a few guys,…
Nets would draft John Wall with top pick, are already getting Devin Harris trade calls
May 11, 2010, 1:09 PM EDT
After the season the Nets had, it feels like the only way the karmic scales balance out is if New Jersey wins the draft lottery, if they get the top overall pick in June. The Nets may only have a 25 percent chance at a top spot, but somehow it just seems fair if they…


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New and prospective dog-owners are invited to attend a free seminar hosted by the Humane Associated of Warren County.
Dog trainer Carla Whitaker will lead the seminar, "Set your Adopted Dog up For Success — Tips & Techniques to Use at Home," from 11 a.m. to 12:30 p.m. on Saturday at the shelter, 230 Cook Road, Lebanon.
Whitaker, owner of Positive Paws in West Chester, will instruct new and prospective dog owners on adjustments after adopting a dog and how to cope with challenges of dog-ownership.
The seminar is open to the public (sorry, no dogs), but registration is requested by calling 513-695-2076 or by email at email@example.com

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My husband was letting our dogs out this morning when this lab trotted up to him. She has a red collar on and has a very good temperment. I fell back asleep this morning and when I got up she was gone. We went down to the lower part of where we live this afternoon and there she was with some kids. We stopped and asked them if the dog was theirs and they replied no. We went on about our way and about 2 hours later there is was back up by our house. We called the police and they told me that there was a call on a lab but then later called back and said that the family had already found their dog. I do not want to call and have animal control come get her, I am hoping some one will respond. She is a very well mannered dog, can sit, shake with both paws, good with kids, bias with other dogs (we have them seperated for extra precaution), not affected by cats. If you are missing her please get ahold of me at firstname.lastname@example.com.
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Is Accelerated Testing Reliable for Oxygen-Sensitive Drugs?
By Thomas J. Hurley, Group Leader, Product Development
and Karen Calaman, Product Development Specialist
Multisorb Technologies
Pharmaceutical companies undoubtedly all share a common and intense focus on drug stability. Each drug candidate will be evaluated at very early stages of the development process to determine its inherent stability and susceptibility to degradation caused by exposure to temperature, humidity, oxygen, and light.
Formal stability studies are required to ensure that a drug product will maintain its safety, quality, efficacy, and physical and chemical characteristics throughout a given timeframe, typically termed the expiry date or shelf life. Although "alternative approaches can be used when there are scientifically justifiable reasons," many companies refer to the International Conference on Harmonization (ICH) and FDA guidance document, Q1A(R2).¹
"The storage conditions and the lengths of studies chosen should be sufficient to cover storage, shipment, and subsequent use."¹ Common storage conditions for nonrefrigerated, solid oral-dose products (e.g., tablets, capsules) in climatic zones I and II, include long-term studies (25°C ± 2°C/60% RH ± 5% RH), intermediate studies (30°C ± 2°C/65% RH ± 5% RH), and accelerated studies (40°C ± 2ºC/75% RH ± 5% RH). For purposes of this document, the accelerated and long-term study conditions will be discussed.
Accelerated testing is designed to increase the rate of chemical degradation or physical change of a drug product by using exaggerated storage conditions. These studies can be used to support the long-term stability studies, sometimes referred to as real-time studies, which ultimately determine the drug product shelf life or expiry date in its commercial package.
The accelerated stability study data, typically conducted for 6 months, can be extrapolated to propose a real-time shelf life.² However, it is important to beware of a one-size-fits-all mentality. Typically, six months of acceptable accelerated testing data are needed as proof that this same system will pass the battery of stability tests for two years of long-term (expiry date) testing at 25°C/60% RH. Caution should especially be exercised when dealing with drug products with primary degradation pathways that are oxidative.
Moisture Transmission—Reasonable Comparison
Relative humidity (RH) is defined as the partial vapor pressure of water in air divided by the saturated vapor pressure of water in air, p/p₀. The saturated vapor pressure is temperature dependant and is defined as the maximum amount of water vapor air can hold at said temperature. Therefore, for accelerated stability studies conducted at 40°C and 75% RH, there is a higher water vapor content than long-term studies conducted at 25°C and 60% RH. This fact, coupled with polymer changes that typically occur at higher temperatures, results in an increased rate of permeation.
Consider a standard, 75-cm³ round, high-density polyethylene (HDPE) bottle with a foil induction seal selected as the container closure system proposed for marketing of a drug product (e.g., solid oral-dose tablet or capsule). For demonstration purposes, assume there is enough desiccant (e.g., molecular sieve) within the bottle to maintain a 0% or near 0% equilibrium relative humidity (ERH) within the bottle. These conditions allow for a constant ∆RH between the external and internal conditions, 75% and 60% for accelerated and long-term stability conditions, respectively. Additionally, assume the bottle has an approximate surface area of 18.2 in.² and an average wall thickness of 30 mil.
The moisture vapor transmission rate (MVTR) for a typical HDPE resin, Marlex HHM 5502BN, is 0.381 g-mil/100 in.²/day and 0.085 g-mil/100 in.²/day at test conditions of 38ºC/90% RH and 25°C/60% RH, respectively.³ Since the MVTR for HDPE is fairly linear at constant temperature, the aforementioned MVTR at 38°C/90% RH can be adjusted to match ICH-recommended conditions of 75% RH as follows: 0.381 g-mil/100 in.²/day × (75/90) = 0.318 g-mil/100 in.²/day.
Using simple mathematics, the ingress can be calculated at accelerated and long-term conditions as expressed in the shaded box at right.
The total amount of moisture vapor ingress is relatively comparable at accelerated storage conditions for 180 days and long-term storage conditions for 730 days. If the drug product and sorbent weights, initial moisture contents, and sorption isotherms are known, a pseudo-empirical simulation can be generated to more closely model the moisture vapor ingress and equilibrium relative humidity conditions within the bottle over the duration of the testing periods.⁴
Oxygen Transmission—A Deceptive Comparison
Although hydrolytic reactions are among the most common processes for drug degradation, some pharmaceuticals are also subject to oxidation, either by reaction with molecular oxygen or reaction with other oxidizing agents present in the formulation.⁵ Some oxidative degradation is moisture mediated, in which case a very aggressive desiccant can sometimes be used to mitigate the degradation reactions. However, in cases in which desiccants are not a viable solution for stabilizing oxygen-
sensitive compounds, oxygen scavengers or specialty bottles (e.g., EVOH, multilayered) are considered as
With speed to market being crucial, it's clear that there is value in ICH accelerated stability testing. As previously mentioned, the increased temperature and RH will typically have some effect on the permeability of the drug package polymer. However, whereas overall moisture transmission is relatively comparable at accelerated and long-term storage conditions and durations due to changes in the polymer properties and total moisture content in the air of the stability chamber, the oxygen concentration in the environment outside of the bottle is constant (~20.8%) at accelerated and long-term testing conditions. Although there are polymer changes that typically occur at elevated temperatures, which increase the oxygen permeability of the bottle, these changes do not compensate for the lack of a differential external oxygen concentration. Thus, for packages incorporating an oxygen scavenger, the headspace oxygen concentration after 180 days of accelerated testing is not necessarily equivalent to 730 days of long-term testing. This can result in a false sense of security and potential long-term stability failure.
Pseudo-empirical modeling is especially valuable to oxygen-sensitive drug products requiring oxygen scavengers. A good mathematical model will incorporate the oxygen transmission rate (OTR) of the polymer, the surface area and thickness of the package walls, the void volume within the package, and the absorption kinetics of the appropriately formulated oxygen scavenger. This model can then produce a complete picture of the internal oxygen environment of the package throughout the specified shelf life and can assist drug formulators and packaging engineers with evaluating the effects of the package selection.⁶
Consider the same bottle choice mentioned in the previous section. Assume the overflow volume for this bottle is 84 cm³ and is packaged with a drug product and a known quantity of appropriately formulated oxygen scavenger such that there is a total of 40% void volume. The oxygen transmission rate (OTR) for the HDPE resin is 111 cm³-mil/100 in.²/day-atmosphere and, based upon supporting data, 205 cm³-mil/100 in.²/day-atmosphere at test temperatures of 25°C and 40°C, respectively.⁷ HDPE is a relatively hydrophobic polymer, and any moisture dissolving in the polymer itself is minimal. Therefore, varying humidity levels do not significantly affect the ingress of oxygen.
If an individual calculated the total amount of headspace oxygen at the time of packaging as well as the amount of oxygen ingress over 180 days of exposure to accelerated stability conditions, they would most likely suggest using a scavenger with an approximate minimum capacity of 50 cm³ of oxygen, as shown below in the shaded box below.
Accounting for a safety factor and exposure and handling of the scavenger, the simulated model of an oxygen scavenger with 100 cm³ of O₂ capacity is presented in Figure 1.
This same sorbent selection, 100-cm³ O₂ capacity oxygen scavenger, is simulated at long-term stability conditions. As can be seen in Figure 2, the resultant oxygen concentration within the bottle would be much higher than anticipated based upon the accelerated testing. In actuality, it would have been more prudent to use an oxygen scavenger with 200 cm³ of O₂ capacity to achieve a comparable oxygen concentration within the headspace of the bottle after 730 days of long-term testing.
Figures 1 and 2 illustrate that insufficient sorbent quantity or packaging may be selected based upon 6 months of accelerated testing data. Selections based on simulations or models of 730 days storage (or other desired shelf life) at long-term stability conditions can result in more accurate packaging decisions and avoid the unpleasant surprise of drug product failure due to drug product degradation prior to the anticipated shelf life.
Bottle Selection for Oxygen-Sensitive Drug Products
Specialty bottles (e.g., EVOH, multilayered) are sometimes considered because of their enhanced barrier properties to oxygen when compared to standard high-density polyethylene bottles. These specialty bottles are typically more expensive than standard bottles and add another inventory item for pharmaceutical companies to manage. Also, unless a company decides to potentially invest capital for inert-gas flushing on their packaging lines, there will be oxygen present in the void volume of the bottle. An oxygen scavenger will most likely still be required to manage this oxygen and the ingress over time.
It has already been shown that an appropriate modeling program can be utilized to optimize the sorbent selection. The choice of a standard HDPE bottle with a larger amount of oxygen scavenger, or a specialty bottle with a reduced amount of oxygen scavenger, typically leads to a cost-benefit analysis—performance versus cost (materials, capital, and resources).
The unique properties and needs of each drug product in combination with the variety of active and static packaging options available in the market today point to the importance of an accurate modeling program to potentially save pharmaceutical companies great sums of time and money in getting their product to market successfully.
1. United States Food and Drug Administration, Guidance for Industry: Q1A(R2) Stability Testing of New Drug Substances and Products, Revision 2, Maryland: ICH, 2003.
2. United States Food and Drug Administration, Guidance for Industry: Q1E Evaluation of Stability Data, Maryland: ICH, 2004.
3. Chevron Phillips Chemical Co., Texas: Sept. 2005.
4. Hurley, Thomas J., and Stanislav E. Solovyov, "The Science Behind Sorbent Selection," Pharmaceutical Technology Europe, June 2008.
4. Waterman, Kenneth C., and Roger C. Adami, "Accelerated Aging: Prediction of Chemical Stability of Pharmaceuticals," International Journal of Pharmaceutics 293 (2005): 101-125.
5. Modeling and simulations are intended as references and are not substitutes for empirical testing.
6. Plastics Design Library, Permeability and Other Film Properties of Plastics and Elastomers, New York: Plastics Design Library, 1996.
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Yemen Dancing on the Heads of Snakes Victoria Clark
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- Publication date:
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Yemen is the dark horse of the Middle East. Every so often it enters the headlines for one alarming reason or another - links with al-Qaeda, kidnapped Westerners, explosive population growth - then sinks into obscurity again. But, as Victoria Clark argues in this riveting book, we ignore Yemen at our peril. The poorest state in the Arab world, it is still dominated by its tribal makeup and has become a perfect breeding ground for insurgent and terrorist movements. Clark returns to the country where she was born to discover a perilously fragile state that deserves more of our understanding and attention. On a series of visits to Yemen between 2004 and 2009, she meets politicians, influential tribesmen, oil workers and jihadists as well as ordinary Yemenis. Untangling Yemen's history before examining the country's role in both al-Qaeda and the wider jihadist movement today, Clark presents a lively, clear, and up-to-date account of a little-known state whose chronic instability is increasingly engaging the general reader.
Our free download, Crisis in the Arab World, contains extracts from this book
Victoria Clark is a former correspondent and Moscow bureau chief for the Observer. She now works as a freelance journalist and writer, contributing to the Independent, Prospect magazine, and the Tablet.
"Before Nato sends in troops or America orders a bombing campaign, the West would do well to take one precaution and read Victoria Clarks excellent new book on the country, part history and part travelogue. Clark leads the reader through Yemens turbulent past with humour and perception
The country is still evidently under her skin." Richard Beeston, The Times
"For the armchair commentators at Fox News and similar organizations, this book ought to be required reading. It is easily the best and most readable account of Yemens current problems and their daunting complexity
Clark wonders how much longer Yemens president can keep up his dance before the snakes finally get the better of him." Brian Whitaker, The Guardian
"The most telling interview is with Tariq al-Fadhli, sometimes cited as the countrys top jihadist
His progress from scion of a powerful tribe to Afghan jihadist, then back to collaborator with Mr Saleh and now, in all probability, a leading formenter of southern secession is one of Ms Clarks brilliant lessons in Yemeni history. This book is compulsory reading for anyone who wants to get to grips with Yemens pit of slithery serpents." The Economist
"Clark shows very well how everyone has drawn a blank in Yemen
Sensibly Clark concludes by recommending that the West simply pay the Saudis to deal with it, rather than getting dragged into yet another interminable front in the war on terror.'" Michael Burleigh, Literary Review
"An experienced foreign correspondent casts a timely light on the complex fissiparous, impoverished country now seen as a haven for Al-Qaeda." -Harry Eyres, Financial Times
"Untangling Yemens history before examining the countrys role in both Al Qaeda and the wider jihadist movement today, [Victoria Clark] presents an up-to-date account of a state that ought to be better known."Fred Rhodes, Middle East
"Clark's command of her subject allows her to write in a serious but fluid style that acts to invite readers from all backgrounds to delve into her world of Yemen."The Majalla
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We are Macmillan. Cancer Support
Pentre Mawr
Pentre Mawr, supported housing for older people in Abergele which is run by Clwyd Alyn Housing Association have again been busy knitting chicks for Macmillan Cancer Support.
Tesco in Abergele donated the creme egg to insert in the chicks.
This year is especially poignant as Beryl Jones, who was a resident passed away recently, days after completing a batch of chicks. Her daughter in law, grand-daughter and great grandson was asked to represent her in the presentation.


text: Employment – Whistleblower Claim – Statute Of Limitations By: Michigan Lawyers Weekly Staff in Employment Law, Michigan Court of Appeals (Unpublished Civil), Opinion Digests June 26, 2006 Whistleblower Claim - Statute Of Limitations Subscribe Login Email Address: Password: Already a paid subscriber but not registered for online access yet? For instructions on how to get premium web access, click here.Forgot your password? Interested in subscribing?Start by choosing how you'dlike your news delivered. Share this:EmailPrintFacebookLinkedInTwitterGoogle +1 1:00 am Mon, June 26, 2006 Michigan Lawyers Weekly Michigan Lawyers Weekly Staff


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Destiny and Desire
By: Edith GrossmaneBook Publisher: Random House
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Winner of the Cervantes Prize
Carlos Fuentes, one of the world's most acclaimed authors, is at the height of his powers in this stunning new novel—a magnificent epic of passion, magic, and desire in modern Mexico, a rich and remarkable tapestry set in a world where free will fights with the wishes of the gods.
JosuÉ Nadal has lost more than his innocence: He has been robbed of his life—and his posthumous narration sets the tone for a brilliantly written novel that blends mysticism and realism. JosuÉ tells of his fateful meeting as a skinny, awkward teen with JericÓ, the vigorous boy who will become his twin, his best friend, and his shadow. Both orphans, the two young men intend to spend their lives in intellectual pursuit—until they enter an adult landscape of sex, crime, and ambition that will test their pledge and alter their lives forever.
Idealistic JosuÉ goes to work for a high-tech visionary whose stunning assistant will introduce him to a life of desire; cynical JericÓ is enlisted by the Mexican president in a scheme to sell happiness to the impoverished masses. On his journey into a web of illegality in which he will be estranged from JericÓ, JosuÉ is aided and impeded by a cast of unforgettable characters: a mad, imprisoned murderer with a warning of revenge, an elegant aviatrix and addict seeking to be saved, a prostitute shared by both men who may have murdered her way into a brilliant marriage, and the prophet Ezekiel himself.
Mixing ancient mythologies with the sensuousness and avarice and need of the twenty-first century, Destiny and Desire is a monumental achievement from one of the masters of contemporary literature.
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"Together, America can do better." When you hear that, do you feel inspired? I didn't think so.
The Democratic Party's current slogan seems to be leaving most people cold. It apparently went down well in focus groups, but that's only because the focus groups probably consisted of the recently embalmed and the alternative slogan was "Together, America can achieve mediocrity." Watching the Democrats stumbling around in search of a "message" is the only thing more agonizing than watching the Republicans destroy this country. Five years of Republican-controlled government have brought us an unwinnable war, a global reputation in tatters, incomprehensibly irresponsible fiscal policies, shameful neglect of our neediest citizens and a government incapable of coping with either natural disaster or terrorist threats. Yet somehow the Democratic Party still can't do any better than "America can do better." "You can do better" is what you say to a dim child whose grades were even worse than expected. Is this really the Democrats' message to the nation: that we don't need to be quite as pathetic as we now are, though excellence is certainly beyond our reach? This slogan speaks not of hope but of hopelessness, of scaled-down ambitions, of dreams deferred and dreams denied. It's the smallness of it that kills me. This nation began with a dream — a crazy, risky, breathtaking dream of freedom, justice and equality. Sure, we've never truly achieved that dream, but for much of the last century, it's been the Democratic Party that has helped keep that dream alive. So how can it be that, today, Democrats don't seem to stand for anything at all? Part of the problem is ambition and cowardice, which together make a lethal combination. Too many would-be Democratic leaders think that "playing it safe" is the way to go. They're fine with criticizing the administration, but the minute they take any flak themselves, they go scurrying back into their holes. In place of a willingness to take risks and speak from the heart, they offer a craven and misguided dependence on polls, focus groups and "expert strategists." Exhibit A for this was John Kerry's astonishing campaign-trail failure to stand up for his own anti-Vietnam War beliefs. As far as his campaign strategists were concerned, the only permissible references to Kerry and Vietnam were those lauding his military valor. But Kerry's worrisome inability to own his own past beliefs left even many Democrats queasy about his candidacy and rendered him vulnerable to Republican charges of hypocrisy and disingenuousness. Had Kerry spoken out honestly and courageously instead of just playing games with flags and staged salutes at the convention, the smear campaign of Swift Boat Veterans for Truth would have gotten no traction and Kerry might be president. So far, the Democratic Party seems to have learned little from Kerry's defeat. Hillary Clinton continues to parse her words on Iraq while saving her carefully calibrated enthusiasm for a ban on flag burning. If Democrats really want a better message, they've got to stop being so technocratic and careful and learn how to be passionate and brave. Of course, they need policies, but they also need a little poetry. The irony is that for a brief moment in the summer of 2004, Kerry actually hit upon a decent campaign slogan: "Let America be America again," a phrase inspired by Langston Hughes' poem of the same name. But the right quickly attacked, using Hughes' 1930s flirtation with communism to discredit the poet, the poem and any phrases or sentiments inspired by it. The result? Kerry disowned the slogan as quickly as he had disowned his own past antiwar convictions. But if the Democrats want a new slogan for 2006, they could do worse than rescue Hughes' poem from the scrapheap:
Let [America] be that great strong land of love . O, let my land be a land where Liberty Is crowned with no false patriotic wreath,But opportunity is real, and life is free,Equality is in the air we breathe . O, let America be America again — The land that never has been yet — And yet must be
Rosa Brooks is a professor at the University of Virginia School of Law. Her experience includes service as a senior advisor at the U.S. State Department's Bureau of Democracy, Human Rights and Labor, as a consultant for the Open Society Institute and Human Rights Watch, as a board member of Amnesty International USA, and as a lecturer at Yale Law School. Brooks has authored articles on international law, human rights, and the law of war, and her book, "Can Might Make Rights? The Rule of Law After Military Interventions" (with Jane Stromseth and David Wippman), will be published in 2006 by Cambridge University Press.
© 2006 The Los Angeles Times
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What We Offer
Working with youth and adults in schools, community organizations, and alternative environments, Project Respect has developed a broad and interactive curriculum to engage participants in exploring the root causes of violence. The workshops are intended to create space for participants to learn from their own experiences, and develop the knowledge and language to express their sexual values and boundaries, and to promote a culture based on respect.
We offer:
- Respect Workshops for schools, community organizations, youth groups, and others.
- Pro-D Workshops for teachers and administrators seeking to gain skills in addressing gender stereotypes and heteronormativity in their classroom/work environments.
- Specialized Workshops in areas such as peer helping, empowerment, media, and others on request.
- Young Men's Groups to engage with all male groups and open up dialogue around issues of masculinity and sexualized violence.
- Rhizome Youth Social Action Projects which are longer-term, social action based engagements with a group of youth who are supported in becoming leaders in violence prevention initiatives amongst their peers.
For more information on any of these programs or to discuss specific needs or requests, please contact the Project Respect office at: (250) 383-5545, ext. 152 or e-mail: firstname.lastname@example.com
Respect Workshops: Project Respect offers a series of two-part workshops for youth 14-19. The workshop, led by a team of male and female facilitators, educates youth about what sexualized violence is and challenges them to think critically about messages they receive from the media and their peers about sexuality and violence.
Using fun games, discussion, and other tools youth learn how to identify and communicate sexual boundaries, learn why asking for consent and challenging gender stereotypes is important. Whether young people are sexually active or abstinent, this program empowers participants to set their own limits.
The workshops are designed to be delivered to youth in a classroom or community setting on consecutive days or weeks, but the program can be adapted to meet specific group needs. Please contact the Project Respect office at (250) 383-5545 (ext. 152) or firstname.lastname@example.com for more information.
Pro-D Workshops: This youth-adult co-facilitated workshop was designed by Project Respect's Youth Social Action Team, Rhizome. Throughout this workshop, teachers will be encouraged to explore how they can use their position of power within schools to create environments that are safer for all students and coworkers to live, learn, and thrive.
Specialized Workshops: In addition to the Respect Workshops that focus on gender, sexualized violence, consent, and positive sexuality, Project Respect offers one to three-session interactive workshops in other areas, by request. The workshops are intended for youth aged 14-19 and, in the past, have addressed topics such as peer helping and leadership, media literacy, empowerment, and social action. Some workshops have also been facilitated for young adults, youth workers, community volunteers, and others in the helping profession.
The workshop are led by a co-ed team and maintain their focus on preventing sexualized violence. The facilitators use interactive modules, role plays, and other tools to help students to learn about the various aspects involved in the prevention of sexualized violence. It is recommended that the group have a grasp of the themes discussed in the regular Respect Workshops before participating in select specialized workshops.
Contact the Project Respect office at (250) 383-5545 (ext. 152) or email@example.com for more information about the types of workshops, scheduling, and costs.
Young Men's Group: The Young Men's Group (YMG) is a 4 to 6-session program delivered by Project Respect and facilitated by two male educators. The YMG aims to engage young men, opening up dialogue about their struggles with traditional masculinity and the issue of sexualized violence. The group consists of all male participants and facilitators, which allows for a safe and comfortable environment, giving men the opportunity to speak on these issues with young adult male mentors.
Working with men as allies, providing education around the role that gender socialization plays, and fostering accountability in men are integral parts of the work of Project Respect and of the YMG. These workshops are flexible depending on the need of the group and the availability of the young men. Project Respect also welcomes partnerships and co-faciltation opportunities with other organizations and male educators. Please contact the Project Respect office at (250) 383-5545 (ext. 152) or e-mail email@example.com for more information.


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Round Tower & High Crosses
The Protestant church of St Columba , west of the town centre, has a 30m-high 10th-century round tower on the southern side. It's without its conical roof, but it's known to date back at least as far as 1076, when the high king of Tara was murdered in its confined apartments. Inside the churchyard are four 9th- century high crosses in various states of repair.


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Before filling out a request for a Food and Beverage Waiver, please contact the Bryn Mawr College Dining Services. If your group is planning an event, Bryn Mawr Dining Services can usually accommodate your food and supply needs at a reasonable price.
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For OC'ing what is the best liquid cooling system/parts money can buy?
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Car boarding ferry falls into river in Va.
Thursday - 8/8/2013, 8:23am  ET
JAMESTOWN, Va. (AP) -- Authorities say a driver escaped injury after her car fell into the James River as she was boarding a ferry.
The Virginia Department of Transportation suspended the Jamestown-Scotland Ferry service after the accident occurred around 8 p.m. Wednesday.
VDOT spokeswoman Lauren Hansen tells media outlets that ferry service resumed Thursday morning.
Hansen says the ferry Surry began to pull away from the pier while the car was boarding. The female driver got out of the car and swam to the dock, where she was pulled out of the river.
A wrecker pulled the car out of the river Thursday morning.
Wrecker taking car that fell off Jamestown- Scotland ferry away from dock https://t.co/Q5uiXZ0BMi
— Darragh Copley (@DarraghatWTKR) August 8, 2013
Hansen says the accident is under investigation.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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The classic Dr. Seuss story of boy who searches for the one thing that will win the affection of the girl of his dreams. To find it he must discover the story of the Lorax, the grumpy creature who fights to protect his world (Danny DeVito).
Dr. Seuss' The Lorax Trailer #2
John Carter Trailer #2
Jeff, Who Lives At Home
John Carter
Happy Feet 2
Dr. Seuss' The Lorax
The Hunger Games
Sherlock Holmes: A Game Of Shadows
Harry Potter and the Deathly Hallows Part 2


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Time Spent on Task.
When ticking a task complete maybe as a option allow us to set a time spent on task (minutes, hours, days).
A graph for this would also be good to see how much time we are spending on each project.
All responses
Vote, void, vote! It is very necessary feature!
I made a suggestion of integrating with a couple of online time tracking tools before I saw this.
Maybe also incorporate a clock start/stop timer to count on-line the time you dedicate to a specific project, ...
Very interesting for a freelancers who need to count the time they dedicate a specific projects.
Also useful when calculating and planning your day - being able to allocate the estimated time to complete each task would allow for better assignment of daily tasks - it is useless to have 15 hours of tasks fit into a 10 hour work day. In addition, it is more meaningful to know how much time is spent on a task(s) or a project rather than how many tasks you knocked out in a day.
Would love the ability to track time along with tasks like Toggl and SlimTimer. I currently use SlimTimer for this and track by overall project level there, but would be much better if directly integrated into Todoist and Wedoist.
Yes, I will start using todoist when a slimtimer-ish feature is included. Todoist is useless to me without it, but I'd happily pay for premium if I could track my time and then spit out graphs and tables of the discrepancies between time spent and time budgeted.
Agree. if tracker will be premium only feature it will be OK.
I'd like this a lot, yes.
There could also be an estimated time option
Great suggestion
Very needed feature!
Even a simple 'Difficulty level' or 'Points' for each task. As you complete a task you earn points and get a better picture of you ability to complete tasks. Similar to Karma but you set how it is calculated.
Yes, I agree that this is a very needed feature! I would love to be able to integrate my time management with Todoist, and especially to be able to see total time spent in different projects when visualizing my completed tasks - a pie chart of time spent on each project rather than number of tasks completed would be MUCH more useful.
This is a critical feature! I purchased the premium Todoist because I really enjoy the layout and ease of use. However, as a personal assistant I work on 5 different businesses for one employer. I need to be able to track how much time I've spent on each task in each project (business) so I can bill accordingly. A customizable report showing a breakdown of the data that I can export to XLS would also be very helpful so that I can see all the data and hours worked for each pay period.
I use slimtimer in conjunction with todist. As such I value the suggested change.
It would be a huge help to control overscheduling if we can allot anticipated time required to complete a task.
something like you can hit start for the task and stop and it will time you, and you can also allocate time, and it will tell you when you go over, how much you have, so you can really plan out your time.
like Klok 2 basically, but integrated.
Great suggestion and very needed feature!
I would be able to convert my entire office of employees over to ToDoist with this feature!
If you could utilise Zapier (www.zapier.com) and do this for Harvest (www.getharvest.com) it would be AWESOME!
Isn't this essentially the same proposal as https://todoist.com/Vote/showProposal/259/ ?
Hello Jirka,
We think these are separate proposals because one suggests the addition of an option that will allow you to track the actual time you spend on the task (like a stop-watch) while the other would allow you to set a timeframe for a task (in terms of - planning the time instead of tracking it).
We may of course consider both options in the future.
Best regards,
This would be very useful. It could probably be integrated nicely with your awesome reporting system.
This would really be a killer feature.
This would be amazing. Also, the ability to exclude a project from the analysis would be helpful.
For example, I do batch processing of emails as a task under "task organization" and set reminders for that. To exclude that project would be great as since this is something I do everyday twice daily, can take up a bit of space in the chart and inflate the productivity trend.
This would help so much when tracking projects where we bill by the hour...good idea
Great suggestion
Oh, that would be an awesome feature. I do need to know time I've spent on work tasks.
This would be amazing. Tracking to-do's and time spent on each task/project separately is painful. :) Would gladly pay for this as a premium feature.
Please add a feature where I estimate the time I have put on the task
This is definitely the feature I am missing the most right now.
That said, I love the simplicity of use and interface right now, so it only adds value if it keeps true to that!
I would love to have my timer integrated with Todoist, but for now, I use Toggl. I love it because it's free and I can use it on both my laptop and iPhone (though it can get a bit confused if I start a timer on one and try to stop it on the other before refreshing). I also don't feel like I'm duplicating all my tasks into it because I can use a simpler name in Toggl that covers several tasks in Todoist. For example, I'm a law student and want to track how much time I spend on each class, but while Todoist has a task for ever day's reading, I just time it all in Toggle under "Class A Reading," "Class B Reading," etc.
I'm all for some toggl integration
I was just looking into whether or not the premium version of Todoist has time tracking on a task, project & day level. I'd love to see this added.
I love the toggle integration suggestions. I'm now using both Todoist and Toggl so to have them integrated would be a dream come true!!
+1 to this feature. I cant justify spending money on this product until such a neccessary (and basic) feature is included!
This would make todoist a complete product.
Toggl is the perfect example of the features we need.
This is a really important feature for me, and will be a dealbreaker eventually if something like this is not implemented.
I for one would be fine with integrating it with toggl. No need for you guys to reinvent the wheel, and they've done a great job over there.
Yep, using both Toggl and Todoist. Having them both in Outlook in one addin would be amazing.
+1 for toggl button on todoist.
I need this one too
This will be very good feature
Absolutely good idea. Needed in future update :)
Oh yes, this would be a great feature! My current "pie chart" is not an accurate reflection of my work distribution, since each task is weighted evenly, though some tasks take hours and others take minutes.
Yes Please!
would love for this to be included as I am currently looking for something to track time spent on projects
would love for this to be included as I am currently looking for something to track time spent on projects
+1 I would love to see this added. This would be the #1 feature missing IMHO. Thanks for the great product.
This would be an extremely nice feature. Adding value to an already good package
If / when this functionality is added to ToDoist it would be helpful to include the ability to link tasks to tags on ManicTime (www.manictime.com) which sits in the background and records activities so that they can be assigned to projects at the end of the day / week rather than relying on manually starting and stopping the clock for each activity. Unfortunately it is apparently not (yet) possible to provide this software on IOS and Android phones and tablets.
This would be the feature that would get me to upgrade. Currently we use - MeTask, a chrome extension, but it isn't as flexible as we'd like the the developer isn't supporting it any more.
That would be great! :-)
+ 1 vote.


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If you don't know the part# for the pistons used,I would ck to see how far down inthe cylinder the pistons are.Hopefully they are not the "rebuilders pistons" w/ a short 1.54" pin hgt.Also,are you using the PCM & engine/trans mgmt from the 97?If using aftermarket EFI system,most controllers that come with them won't control the 4L60E.The 0411 controller from a 99 up would be the better option.Better tuning options & capability & you can control engine & trans w/ 1 controller.
Flat top pistons. I would like to use the stock EFI system if I can. |
Use 1 of the online DCR calculators to play around with different head chamber sizes & cams to see what your CR would be with different combos.For instance,with flat tops & a 64cc head,you are gonna be in the neighborhood of 10:1 SCR which would be borderline w/ iron heads,but,fine w/ aluminum.Cam choice will also play a role in your final effective CR (DCR) as well. Comp cams XR264HR would be a good choice for good streetable cam depending on what you HP goals are.IIRC,the stock EFI can support approx 400 HP.
The type pistons used are not the only determining factor in your final CR.Chamber volume,headgasket thickness/bore, piston to deck hgt. all play a role in your final CR.It's important to know how far your pistons are down the cylinder to determine the parts used to complete the build.If pistons with a shorter pin hgt were used,(1.540" vs 1.560"),your pistons could already be up to .045" plus the thickness of the head gasket used.Optimum quench,(the distance between head deck & piston top is .039 to .045.If your pistons are already .045 down w/o the gasket,you will want to keep CR relatively mild to avoid detonation.Proper quench helps to deter detonation & provides a more complete & efficient burn.
If this is a 19971 350 LT1 Gen II motor you can only use a GENII style head on it.
LT1 or Lt4 motor. Where are the stock heads for this motor? Stock EFI intake manifold etc? |
Assuming I can get ahold of the shop, and they actually know what I'm talking about, is there another way of determining where the piston is in the bore? |
Yes, I got the entire engine (with accessories still on it) , trans, wiring harness and computer. It was an LT1 aluminum heads, gear driven water pump etc. I believe the heads are small valve and would need to be reworked to be of any rear use. I think that the benefits of a new set would outweigh what I would get by having my old heads redone. RIGHT?????
You can measure the depth of your pistons with a depth mic,or,in a pinch,you can use a straight edge across the cylinder top & use feeler guages to get a somewhat close idea of the the deck hgt.You will wanna measure @ least on all 4 corners with that piston @ TDC.If the block hasn't been decked,the pistons should be .025" to .030 deep.If they are any deeper,the shop used "rebuilders pistons" with the shorter pin hgt.If so,changing pistons,or,decking the block would be your only way to correct it.If neither of those is an option for you,use a .015" shim gasket to get quench as tite as possible with what you have.This will give you approx .060" quench.The stock heads are not bad heads with some work.F'bird can give you best course of action what needs to be done with them,or,recommend a more suitable head for your goals.
The Following User Says Thank You to jokerZ71 For This Useful Post: | ||
techinspector1 (09-04-2013) |
Your engine stock,should have had approx 10.5:1 compression.Your aluminum LT1 heads have 54cc chambers & flow around 212 cfm as is with 1.94" & 1.5" valves.Some porting & cleanup.Maybe up the valve sizes to 2.02 & 1.6. They would probably easily support your HP goals.If the pistons turn out to be the shorter version,your CR will be slightly lower.The overbore will also give you a slight increase in CR.The stock injectors are rated @ 23 to 24 lb/hr.I can see you making 400 HP relatively easy & still maintaining good drivability.Getting a good PCM tune would also benefit you a lot.
The Following User Says Thank You to jokerZ71 For This Useful Post: | ||
techinspector1 (09-04-2013) |
I don;t know It depends on how much power you want to make. I don;t pay other people to port "re work" cylinder heads. I do it my self. Whether its best for you to port your LT1 heads or get and port a set of the LT4 heads or go aftermarket depends on what you are after and what you are willing to do.
Vortecs flow approx 234 or so outta the box & are advertised to support 400HP as is,so'with your heads flowing 212,they will need some work.You do have slightly larger ports,so,IDK how much work we're talkin about.That being said,a set of aftermarket heads would definitely be a good investment,or,having someone rework yours.Get pricing for both & weigh the results.Keep in mind,that you having more flow & velocity is always a good thing.You may decide later to up your power requirements. If I had to guess & assuming you will have all the work hired out,I'd say you could buy a good set of heads for not much more than you'll have invested in yours.I would think that gaining another 22 cfm or so would take some substantial work.Not to mention new guides,seats,valves,springs,& machine work.You could probably sell yours to somebody.They're not bad heads.They just ain't gonna support 400 HP as is.
Last edited by jokerZ71; 09-04-2013 at 03:47 PM. |
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The Rock has started yet another new job on Monday. He noted on Twitter that he has started shooting a television show called Wake Up Call for TNT, which seems to deal with interventions and helping people turn their lives around.
There has been little to no talk backstage of bringing Edge in for a special appearance at Wrestlemanie 30. The belief is that he has moved on from WWE and only made his recent appearance in September to do promotions for Haven, the television show that is currently working on.
After he was pulled from Royal Rumble 2014 at the last minute, Evan Bourne told fans on Twitter that he was still working on making his return to WWE, but as of right now, it does not appear that management is making that a priority backsage.
At one point, Evan Bourne was supposed to make his return to WWE at Royal Rumble 2014, but management opted against that move on Sunday night. The high flying wrestler decided to address the issue on Twitter by telling his fans to not worry about last night and that he is still working on his comeback.
Rumor has it that Evan Bourne is expected to make his return to WWE soon, and many believe that management will be making that happen at the Royal Rumble pay per view as a mystery entrant. He has recently been taking it up a notch with his workouts.
After a lengthy absence due to an injury, Evan Bourne has been waiting to make his return to WWE. The high flying performer has been teasing fans through Twitter that he could be doing that at the Royal Rumble as a mystery entrant.
Since the creative department doesn't have a story line readily available for him, the belief is that Evan Bourne will be returning to WWE as a mystery entrant during the Royal Rumble. Management is looking for some surprises at the show.
Evan Bourne joked on Twitter about his Slammy award that was stolen by former WWE star Mike Knox.
WWE officials expect Evan Bourne to return from injuries before the year is over.


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Hi, Doctor Nick! - Finding True Love and Making Music Without Going Broke
- Words: Nick Hook
- Photo: Kareem Black
It's time again for another dose of street knowledge, courtesy of XLR8R's good doctor, Mr. Nick Hook. Nevermind that's he's not actually a doctor—the man has a seemingly endless well of knowledge about life, music, romance, travel, production, and more. Even better, he's willing to share it with the world, so feel free to drop him a line if there's a question itching at your soul. Otherwise, read on and see what Doctor Nick has to say this week, when he takes on the search for true love and how best to balance the desire to make music and the need to make money.
Hi Doctor Nick,
Are many independent musicians you come across able to sustain themselves exclusively through their musical exploits, or is it common to work another job to support themselves?
This is actually a great question and something that was part of my life.
I was signed to this band on Warner Bros. We toured LOTS. I essentially went into debt being on tour, but I did "live" off it. We ended up not being a band anymore, and I was DJing a bunch to make rent, but most of the gigs were fucking terrible: hotels, DJing at the Diesel store, etc. Half the time I was DJing, I was becoming numb to something I loved.
I ended up getting a job at this little sake bar. I was the bartender. I got to invite my friends and build this little crazy world on Mondays. We did a lot of insane things and had a lot of fun. But looking back on it, I think the most important thing was that making money outside of music allowed me to be WAY more picky about the gigs I took.
In our field, perception is reality. I think if people see you doing normal things, they are gonna offer you normal things. If people see you on the rise, they are going to help you rise. It's easy to make 200-300 bucks a night and get wasted four or five nights a week DJing in New York, and it's really addictive, but I feel like at the end of the day, it's a major dead end.
I could go on about this for hours, but speaking for myself, I always try and look back and think about when I was 13 years old. I didn't start making music for money, I just liked it. If we keep those ethics as we get older, I think we stay pure with it. Once you try and make it your job, you start doing things you don't love, and people can sense that.
Hi Doctor Nick,
Where can I meet a nice girl? One that likes long walks on the beach, romantic candlelit dinners, and doesn't care about DJs. Are clubs a good place to find such a girl?
I think the general rule of thumb here is less than 11 mutual friends on Facebook and they can't be a fan on Diplo. That's if you are trying to go on that candlelit steeze.
Clubs are tight to find some good energy, fun, trouble, and, you know, the things that are on that microwave, but I think if you are looking for the four-letter L-word, stay away from the club.
Here are some places I recommend you start:
the library
local coffee shop
the bus
the botanical garden
the comic book shop
the sake bar I work at
I can't say I've tried it myself, but on the real, some of my people have had some good experiences with OkCupid. At least you get to go outside of your normal circle and see what's there. One of the most important things I've learned is that finding out what you don't want is almost more important than what you do. Also, if a relationship is all about sharing, how are you going to keep things fresh when you are both at the same shows and reading the same advice columns on XLR8R? You need chicks to be showing you country songs and stuff.
Good luck son. Remember, let it happen naturally. Don't force it. We always got music to make and things to learn if these chicks aren't feeling us.
Hi, Doctor Nick appears every Thursday on XLR8R. Do you have a question for Doctor Nick? Please submit your inquires to email@example.com. Nick Hook can help you.
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Looking at the official spec sheet the GT 520 will have 48 CUDA processing cores, an 810MHz core clock speed, a 1620MHz shader speed, 1GB of 900MHz DDR3 memory, and a 64-bit memory interface providing a total bandwidth of just 14.4GB/s. The card features a low-profile design and a single-slot cooler that in all require only 29W of power. Like other Nvidia GeForce 500 series cards, the GT 520 will also support the company's PhysX and 3D Vision technologies.
Curiously, according to Nvidia's own performance charts, the card will be quite a bit slower that the $60 GeForce GT 430 and more on par with the old GT 220 and even the GeForce 9500 GT that was launched almost three years ago. Basically the improvement is in the power consumption front and smaller footprint.
The GeForce GT 520 is available now from Nvidia's add-in-board partners, which may make some tweaks to Nvidia's standard design like offering passive cooling. The card will also show up in pre-built systems from major manufacturers.
User Comments: 3
Got something to say? Post a comment-
I was hoping to see a little better performance for this. I would rather stick with amd/ati for the better speed in computing. This is really just a tiny step above integrated. It might give you a lot better performance across two monitors, but forget it for a single monitor. Just my opinion.
This card is not so good compared to the "Radeon HD 5670" for $90 USD. The "GT 520" only benchmarks at 375 on passmark.com. The "Radeon HD 5670" benchmarks at 1247. That is a huge difference in performance for me and worth the extra 30 dollars. I think it would be a waste to buy the "GT 520" unless it was under $30 USD and didn't go over 30 degrees Celsius lol
If the GT 520 is slower than the older GT 430 then the DDR3-variant of AMD's HD 4650 would probably be a better performer at this price point, depending of course on its availability.
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Style Map
Daily Dispatches From The Global Scene
A round up of the most solid styles; staples for the winter season.
They're not practical and they might not even be pretty, but these shoes all represent the sumptuousness and creativeness designer wear is known for.
A touch of old world russian charm, with unapologetic display of wealth, and a bit of edge.
Some of the most beautiful looks from RTW collections in Paris 2008.
Daily Dispatches From The Global Scene


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Inactivation of Ca Release Channels (Ryanodine Receptors RyR1 and RyR2) with Rapid Steps in [Ca] and Voltage Biophysical Journal, Volume 74, Issue 5, 1 May 1998, Pages 2352-2364 D.R. Laver and G.D. Lamb Abstract The transient responses of sheep cardiac and rabbit skeletal ryanodine receptors (RyRs) to step changes in membrane potential and cytosolic [Ca2+] were measured. Both cardiac and skeletal RyRs have two voltage-dependent inactivation processes (τ≈1–3s at +40mV) that operate at opposite voltage extremes. Approximately one-half to two-thirds of RyRs inactivated when the bilayer voltage was stepped either way between positive and negative values. Inactivation was not detected (within 30s) in RyRs with Po less than 0.2. Inactivation rates increased with intraburst open probability (Po) and in proportion to the probability of a long-lived, RyR open state (POL). RyR inactivation depended on POL and not on the particular activator (Ca2+ (μM), ATP, caffeine, and ryanodine), inhibitor (mM Ca2+ and Mg2+), or gating mode. The activity of one-half to two-thirds of RyRs declined (i.e., the RyRs inactivated) after [Ca2+] steps from subactivating (0.1μM) to activating (1–100μM) levels. This was due to the same inactivation mechanism responsible for inactivation after voltage steps. Both forms of inactivation had the same kinetics and similar dependencies on Po and voltage. Moreover, RyRs that failed to inactivate after voltage steps also did not inactivate after [Ca2+] steps. The inactivating response to [Ca2+] steps (0.1–1μM) was not RyRs "adapting" to steady [Ca2+] after the step, because a subsequent step from 1 to 100μM failed to reactivate RyRs. Abstract | Full Text | PDF (214 kb) |
Ca Stores Regulate Ryanodine Receptor Ca Release Channels via Luminal and Cytosolic Ca Sites Biophysical Journal, Volume 92, Issue 10, 15 May 2007, Pages 3541-3555 Derek R. Laver Abstract The free [Ca2+] in endoplasmic/sarcoplasmic reticulum Ca2+ stores regulates excitability of Ca2+ release by stimulating the Ca2+ release channels. Just how the stored Ca2+ regulates activation of these channels is still disputed. One proposal attributes luminal Ca2+-activation to luminal facing regulatory sites, whereas another envisages Ca2+ permeation to cytoplasmic sites. This study develops a unified model for luminal Ca2+ activation for single cardiac ryanodine receptors (RyR2) and RyRs in coupled clusters in artificial lipid bilayers. It is shown that luminal regulation of RyR2 involves three modes of action associated with Ca2+ sensors in different parts of the molecule; a luminal activation site (L-site, 60μM affinity), a cytoplasmic activation site (A-site, 0.9μM affinity), and a novel cytoplasmic inactivation site (I2-site, 1.2μM affinity). RyR activation by luminal Ca2+ is demonstrated to occur by a multistep process dubbed luminal-triggered Ca2+ feedthrough. Ca2+ binding to the L-site initiates brief openings (1ms duration at 1–10s−1) allowing luminal Ca2+ to access the A-site, producing up to 30-fold prolongation of openings. The model explains a broad data set, reconciles previous conflicting observations and provides a foundation for understanding the action of pharmacological agents, RyR-associated proteins, and RyR2 mutations on a range of Ca2+-mediated physiological and pathological processes. Abstract | Full Text | PDF (312 kb) |
Activation and Inhibition of Skeletal RyR Channels by a Part of the Skeletal DHPR II-III Loop: Effects of DHPR Ser and FKBP12 Biophysical Journal, Volume 77, Issue 1, 1 July 1999, Pages 189-203 Angela F. Dulhunty, Derek R. Laver, Esther M. Gallant, Marco G. Casarotto, Suzy M. Pace and Suzanne Curtis Abstract Peptides, corresponding to sequences in the N-terminal region of the skeletal muscle dihydropyridine receptor (DHPR) II-III loop, have been tested on sarcoplasmic reticulum (SR) Ca2+ release and ryanodine receptor (RyR) activity. The peptides were: A1, Thr671-Leu690; A2, Thr671-Leu690 with Ser687 Ala substitution; NB, Gly689-Lys708 and A1S, scrambled A1 sequence. The relative rates of peptide-induced Ca2+ release from normal (FKBP12+) SR were A2>A1>A1S>NB. Removal of FKBP12 reduced the rate of A1-induced Ca2+ release by ∼30%. A1 and A2 (but not NB or A1S), in the cytoplasmic (cis) solution, either activated or inhibited single FKBP12+ RyRs. Maximum activation was seen at −40mV, with 10μM A1 or 50nM A2. The greatest A1-induced increase in mean current (sixfold) was seen with 100nM cis Ca2+. Inhibition by A1 was greatest at +40mV (or when permeant ions flowed from cytoplasm to SR lumen) with 100μM cis Ca2+, where channel activity was almost fully inhibited. A1 did not activate FKBP12-stripped RyRs, although peptide-induced inhibition remained. The results show that peptide A activation of RyRs does not require DHPR Ser687, but required FKBP12 binding to RyRs. Peptide A must interact with different sites to activate or inhibit RyRs, because current direction-, voltage-, cis [Ca2+]-, and FKBP12-dependence of activation and inhibition differ. Abstract | Full Text | PDF (284 kb) |
Copyright © 1994 The Biophysical Society All rights reserved.
Biophysical Journal, Volume 67, Issue 5, 1834-1850, 1 November 1994
Research Article
A.L. Percival, A.J. Williams, J.L. Kenyon, M.M. Grinsell, J.A. Airey and J.L. Sutko
Department of Pharmacology, University of Nevada School of Medicine, Reno 89557.
To define the roles of the alpha- and beta-ryanodine receptor (RyR) (sarcoplasmic reticulum Ca2+ release channel) isoforms expressed in chicken skeletal muscles, we investigated the ion channel properties of these proteins in lipid bilayers. alpha- and beta RyRs embody Ca2+ channels with similar conductances (792, 453, and 118 pS for K+, Cs+ and Ca2+) and selectivities (PCa2+/PK+ = 7.4), but the two channels have different gating properties. alpha RyR channels switch between two gating modes, which differ in the extent they are activated by Ca2+ and ATP, and inactivated by Ca2+. Either mode can be assumed in a spontaneous and stable manner. In a low activity mode, alpha RyR channels exhibit brief openings (tau o = 0.14 ms) and are minimally activated by Ca2+ in the absence of ATP. In a high activity mode, openings are longer (tau o1–3 = 0.17, 0.51, and 1.27 ms), and the channels are activated by Ca2+ in the absence of ATP and are in general less sensitive to the inactivating effects of Ca2+. beta RyR channel openings are longer (tau 01–3 = 0.34, 1.56, and 3.31 ms) than those of alpha RyR channels in either mode. beta RyR channels are activated to a greater relative extent by Ca2+ than ATP and are inactivated by millimolar Ca2+ in the absence, but not the presence, of ATP. Both alpha- and beta RyR channels are activated by caffeine, inhibited by Mg2+ and ruthenium red, inactivated by voltage (cytoplasmic side positive), and modified to a long-lived substate by ryanodine, but only alpha RyR channels are activated by perchlorate anions. The differences in gating and responses to channel modifiers may give the alpha- and beta RyRs distinct roles in muscle activation.


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Both film versions are presumably fiction, but you can certainly draw some interesting comparisons between the character of Arthur Bach and the life of actor Charlie Sheen. And, in the last three days, radio talk show host Dan Patrick has made a pretty good case for the idea that he could play the role of Hobson, Arthur's friend/confidante and butler.
Twice this week, Sheen has appeared on Patrick's show, which is simulcast on DirectTV and a number of FOX Sports Net affiliates. During the first appearance, arranged by Patrick to discuss Sheen's impromptu pep talk last week to the UCLA baseball team, Sheen came across as cavalierly endorsing casual drug and alcohol use.
On Wednesday, however, Sheen called in, presumably to reduce some of the heat he's been taking, both from Monday and in general from conduct that led CBS and Warner Bros., the network and studio that air "Two and a Half Men," the sitcom Sheen stars in, to shut the show down so as to let Sheen get his act together.
In an often rambling nine-minute conversation, an unrepentant Sheen sought to diffuse speculation that he and Chuck Lorre, the creator and executive producer of the show, were on the outs over his behavior. He said that the "real message" of his talk at UCLA, in which he advised the team to stay away from the crack and drink chocolate milk, was to "enjoy every moment."
But Sheen's message was partially obscured by a nearly total failure to examine the consequences of his conduct. When Patrick asked him if there was anything he said Monday that he wanted to clarify, Sheen said "That would require having a memory of it," before adding, "Sorry, that was kind of rude."
"I don't have (an) answer, man," Sheen said. "I can't tell people what to do. I don't come at people from a place of judgment or opinion. If I've got some facts, that's what I stand on. You take away people's judgment and opinion of you (and) suddenly, that's something that sounds a lot like crickets, because rarely do they show up with the facts."
Sheen dared Patrick to get troubled actress Lindsay Lohan to appear on his show so that he could offer her the advice to work on her impulse control, to "just try to think things through a little bit before you do them."
In perhaps the most troubling portion of his appearance Wednesday, Sheen allowed, for instance, that while he had never come to work drunken or high, he had also been so tired that the show's director needed to move his mark to either a piece of furniture or table so that he wouldn't fall over.
"That's an expert move by a seasoned professional," Sheen said. "An amateur stays on his mark and then falls over during the run-through."
Said Patrick, with a trace of irony: "You're a pro's pro."
Said Sheen: "Thank you."
The whole situation has left Patrick, who did not respond to an e-mail request for an interview, in a bit of a quandary. Clearly, he has access to Sheen, whose conduct has made him one of the hotter topics in the tabloid world. Indeed, Sheen's appearance Monday became fodder for all the entertainment news shows and late night talk shows.
It's a gold mine of virtually free publicity for Patrick and his show, but, in accepting the buzz, does he run the risk of acting as an enabler to Sheen? In the lyrics to the Oscar-winning theme, Arthur is said to be "showing himself a pretty good time," which is certainly his right. But, to what degree should a nationally syndicated talk show host help him?


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Please enter your travel dates.
Twin Room
Double Room
Family Room
Deluxe Double Room
Hotel with 3 restaurants, in Edinburgh (Morningside)
With a stay at Best Western Braid Hills Hotel in Edinburgh (Morningside), you'll be close to Braid Hills Golf Course and Murrayfield Stadium.
This hotel is close to Edinburgh International Conference Centre and Greyfriars Kirk.
Stay in one of 67 guestrooms featuring flat-screen televisions. Complimentary wireless Internet access keeps you connected, and satellite programming is available for your entertainment. Conveniences include direct-dial phones, as well as desks and complimentary newspapers.
Take in the views from a terrace and a garden and make use of amenities such as complimentary wireless Internet access.
Satisfy your appetite at one of the hotel's 3 restaurants. Quench your thirst with your favorite drink at a bar/lounge.
Featured amenities include a computer station, express check-in, and complimentary newspapers in the lobby. Event facilities at this hotel consist of conference/meeting rooms, a ballroom, and banquet facilities. Free parking is available onsite.
Hotel Amenities
- General
Dining is available at one of the hotel's 3 restaurants. A bar/lounge is on site where guests can unwind with a drink. A computer station is located on site and high-speed wireless Internet access is complimentary. Event facilities include conference/meeting rooms, a ballroom, and banquet facilities. This business-friendly hotel also offers a terrace, tour/ticket assistance, and a garden. Complimentary parking is available on site.
Best Western Braid Hills Hotel is a smoke-free property.
- 24-hour front desk
- Total number of rooms - 67
- Ballroom(s)
- Banquet facilities
- Bar/lounge
- Complimentary newspapers in lobby
- Multiple large conference rooms
- Event catering
- Tours/ticket assistance
- Free Wi-Fi
- Computer station
- Luggage storage
- Dry cleaning/laundry service
- Room service
- Express check-in
- Free parking
- Patio
- Garden
- Terrace
- Number of restaurants - 3
- Number of meeting/conference rooms - 2
- Smoke-free property
- Internet
Available in all rooms: Free Wi-Fi
Available in some public areas: Free Wi-Fi
- Parking
Free parking
- Room Amenities
- Direct-dial phone
- Coffee/tea maker
- Complimentary bottled water
- Private bathroom
- Hair dryer
- Desk
- Satellite TV service
- Flat-panel TV
- Free Wi-Fi
- Climate control
- Complimentary newspaper
- Dining
Allemuir Restaurant - This restaurant serves breakfast and dinner. Guests can enjoy drinks at the bar. A children's menu is available.
Buckstone Pub - This bistro serves lunch and dinner. Guests can order drinks at the bar and enjoy alfresco dining (weather permitting).
Room service is available.
- Recreation
The recreational activities listed below are available either on site or nearby; fees may apply.
- Golfing nearby
Policies & Fees
- Check-in
Check-in time starts at 3 PM
Check-in time ends at 11 PM
- Check-out
Check-out time is 11 AM
- Payment types
Accepted at this hotel: American Express, Diners Club, MasterCard, Visa
- Pets
Pets not allowed
- General
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Caters to groups
- Fees
- The following fees and deposits are charged by the property at time of service, check-in, or check-out.
- Pet fee: GBP 6.00 per room, per night
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
- Additional Details
No pets and no service animals are allowed at this property.


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Found December 12, 2012 on
Terez Owens:
It's Belzer T…
Mark Sanchez and comedian Richard Belzer walk the red carpet for the premiere of 'Django Unchained' at the Ziegfeld Theatre in New York City — Sanchez' must be feeling good again if he's showing up to an elective social function. As bad as he's been, somehow the Jets are still in the playoff hunt.-TO
Mark Sanchez Has a Few Fans Left
Mark Sanchez vs Benny Hill
Original Story:
Rex Ryan: Tebow probably disappointed with Jets
BRAYLON EDWARDS: Passed Physical, Hopeful to Play Monday
Braylon Edwards back with the "Idiots"
Tebow won't run wildcat for Jets
Adam Sandler sings at Sandy Relief Concert rips Mark Sanchez & A-Rod
Jets Claim WR Braylon Edwards Off Waivers
Making sense of Rex Ryan's backup quarterback quandary
Braylon Edwards Returns To Jets
Patriots Fan's Pleasure: The Jets Were Even A JOKE In The 80′s, See Mark Gastineau (PHOTO)
The Jets need change.. even with a chance still to make the playoffs
ESPN president: Enough with the Tebow coverage
Adam Sandler Sings at Sandy Relief Concert, Calls Out Mark Sanchez and A-Rod (Video)
NFL Forum Discussions
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A refreshing post-wax gel-cream Contains Magnolia Essential Oil Aloe Vera & Meadowfoam Oil Helps soften relieve & nourish hair just after removal Blended with Clove Essential Oil & Fibraurea Recisa Extract to slow down hair re-growth Minimizes the appearance of skin imperfections like ingrown hairs & redness Skin appears calm clear & blemish-free


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SALLY CAREY, 85, of Prospect Avenue, Plattsburgh, NY passed away on Tuesday Jan. 8, 2013 at Albany Memorial Hospital in Albany, N.Y. She was born in Massena, N.Y. on Feb. 16, 1928 the daughter of Warren and Blanche Frenette. Calling hours will be held from 2 to 4 p.m. and 7 to 9 p.m. on Friday Jan. 11, 2013 at the Brown Funeral Home in Plattsburgh. A Mass of Christian burial will be celebrated at 1:30 p.m. on Saturday at St. John's Church in Plattsburgh. Burial will be in St. Agnes Cemetery in Lake Placid. Arrangements have been entrusted to Brown Funeral Home, 29 Broad Street, Plattsburgh, NY 12901 (518)-561-3980.
- Wednesday
Parades to honor Olympic athletes
Main Streets will welcome Olympic athletes home on March 16 in Lake Placid, March 26 in Saranac Lake.
Vermont towns oppose IP pipeline
Two communities and one agency voted against the spur that would cross the lake and serve the Ticonderoga mill, but the results are nonbinding.
City, town explore increased collaboration
The two Plattsburghs will host a workshop on March 14 to bring government officials and department heads together to meet with their counterparts and generate ideas on more shared services.
Master plan in view for Saranac River Trail
Town of Plattsburgh Complete Streets Committee updated on project. Next meeting is March 26.
Radio Shack to close up to 1,100 stores
The company has not announced which ones, but it has four stores in the tri-county region.
Hogansburg woman charged with aggravated animal cruelty
Shawna A. Bero, 29, was taking care of the dog for a friend who is in Franklin County Jail.
Champlain chimney fire leads to structure fire
Smoke entered the walls of Jeffery and Shelly Peete's home.
Police: NAC student sparked fire in locker room
A teacher doused the flames with a fire extinguisher, but two lockers and some clothing items were damaged.
Students gear up for Regional Spelling Bee
The 2014 Champlain Valley Educational Services Regional Spelling Bee will take place at 6 p.m. Friday at Moriah Central School.
Of Interest: March 5, 2014.
Take a look at news in brief from around the North Country.
- More Wednesday Headlines
Parades to honor Olympic athletes


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Lately I've had problems opening any but HTTPS sites. Strange, I know. I've rebooted, cleared cache, flushed DNS, and, force ranged. This morning I found that if I do the TurboPage teardown and change my selection to Auto Select or Use the Server configured below pages will load. They don't load consistently with either box checked. I just need to change it back and forth to get connected.What could cause this? Would it be something on my end? Is there anything that I can do to keep things up and running without the hassle?Thanks in advance!
based on your comment that you can load HTTPS sites, but not regular sites (try »www.google.com, then »www.google.com), and that you appear to be able to at least temporarily resolve your issue by tearing down your Turbo Page connection, it sounds like there's DNS issue on your current Turbo Page server. under normal circumstances, regular HTTP traffic goes through the Turbo Page server, secure traffic does not. I've seen this issue a few times recently.your options include,-tearing down the Turbo page connection and getting another one as per the NOC's current rules (you may simply be reassigned the same problem turbo page server).-manually inputting invalid turbopage settings, forcing your system to not use any Turbo Page acceleration, ie 0.0.0.0, port 86.-rebooting your modem to attempt to have your Turbo Page server connection reassigned(will essentially be the same as just tearing down your turbo page connection).finally, you should call your appropriate HughesNet tech support contact, and report the aforementioned symptoms, and specifically, mention which current turbo page server you are connected to.you can find that out by going to your System Status page on your System Control Center, then locating the current Operational; Upstream Addr: "xxx.xxx.xxx.xxx" next to "Web Acceleration Status".with that info, they should be able to locate the issue (if one exists), and resolve it in a timely fashion.
1 recommendation
I agree with what Lucas Lee said. When I had Hughes service with a 7000S system, I periodically had the same issue, and I'm confident that the problem was with one or more of the available Turbo Page servers on Hughes end. Unfortunately, my experiences were such that it seemed to take Hughes longer than a reasonable amount of time for Hughes to correct the problems. When dealing with support, the folks in the Near East didn't seem to have any understanding of the problem and didn't seem to have the ability to communicate what I was telling them to anyone who had the ability to resolve the issue.Doing the turbo page tear downs can give you temporary relief, but, unfortunately, the turbo page server to which you are assigned will periodically reset itself, especially after periods of time when your system has been inactive. What I found useful when I had the same issues was to write down the address of the turbo page servers that seemed to work well and, then, when I had a problem because my system was connected to a bad turbo page server, I would manually enter the address of one of the ones that seemed to work well. Again, this is only a temporary solution, and it is a pain to have to do it, but it is a workaround that will, at least, allow you to use the system until Hughes gets around to fixing things on their end.
Every body and there brother it seems is having DNS lookup errors. Seems to run in streaks.They just about had a riot on the Hughesnet forums !It seems to be system wide, not confined to 7000 or 9000s.Hughesnet doesn't seem to admit or address the issue. They just keep wanting everyone to call India.When it acts up I just leave an browser tab open to the teardown function and repeat as needed.
When it acts up I just leave an browser tab open to the teardown function and repeat as needed.
Wild goose chase. HPEP/Turbopage is HTTP only. HTTPS goes around HPEP servers. DNS server is separate from both. Whereas it may superficially appear to be a "TurboPage" problem, it's pretty surely just a continuation of the ongoing DNS issues.//greg//
Sorry, I misread your opening statement. Missed the " but" part. Thought your problem was with HTTPS//greg//


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Quotations, sayings and aphorisms about food and beverages, eating and drinking, food appreciation, restaurants, chefs, cooks, food critics, etc.
Giovanni Giacomo, Casanova de Seingalt (1725-1798) was famous for his romantic adventures. However at age 73 the Prince of Ligne described him as:
"at 73, no longer a god in the garden or a satyr in the forest, he is a wolf at table."
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Share this news story The Northern Irish artist will headline Turrbotax later this month. Space Dimension Controller will DJ at a Turrbotax party on January 25th. Fresh off the announcement of his long-awaited debut album Welcome To Mikrosector-50, Belfast producer Jack Hamill will make his first US appearance since 2011 in New York City. The science fiction-obsessed producer's own music melds classic electro, house, boogie and hip-hop tropes, and his DJ sets follow a similar trajectory, weaving in classic and obscure material along with contemporary tracks. Support will come from a number of NYC locals, including Rush Hour associate Policy and Local Action member Contakt. Residents Rem Koolhaus, CSick, Mayster and Space Jam will round out the lineup. Hamill will make another US appearance the following evening, when he headlines the Icee Hot birthday party in San Francisco. Jan 25 TURRBOTAX® with Space Dimension.., Cameo Gallery, New York Jan 26 Icee Hot 3 Year Annive.., Public Works, California (North) DJ Page: Space Dimension Controller
Sat 15/Mar 2014BerlinStattnacht: Clockwork, Space Dimension Controller, Roman Lindau, Jonas Kopp, Jerome Sydenham
Mon, 13 Jan 2014Post a commentSoup Kitchen announces plans for first half of 2014The Manchester nightspot has outlined its program for the next six months.
Tue, 7 Jan 2014Post a commentMagic Mountain High booked for HarmonizedMove D will also DJ at the outfit's first party of 2014 this weekend.
Mon, 9 Dec 20132 commentsNYE 2013 clubbing guide: UKWe round up the best clubbing options across England, Wales and Scotland this New Year's.
Thu, 17 Oct 201314 commentsR&S announce 30th anniversary compilationFrom Jaydee to James Blake, the venerable label will mark three decades in the game with a best-of selection.
Wed, 16 Oct 20131 commentValhalla Festival announces 2013 lineupEats Everything and Totally Enormous Extinct Dinosaurs will go back-to-back at the Amsterdam event.
Fri, 11 Oct 201326 commentsIbiza 2013 in reviewWith the season drawing to a close this week, Carlos Hawthorn looks back on a summer of extreme highs and lows.
Thu, 3 Oct 2013Post a commentREWIRE returns to The HagueThe multi-faceted festival has enlisted Modeselektor to head its third edition.
Mon, 19 Aug 20133 commentsSpace Dimension Controller kicks off Correlation seriesThe first instalment in a run of conceptual 12-inches for Clone will see release in September.


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Cheney: I Urged Bush To Bomb Syria
Originally published on Thu August 25, 2011 9:52 am
"Former Vice President Dick Cheney says in a new memoir that he urged President George W. Bush to bomb a suspected Syrian nuclear reactor site in June 2007," The New York Times reports this morning.
But Bush didn't follow the vice president's advice — and none of the president's other top advisers thought bombing Syria was a good idea, Cheney adds. The Bush administration had gone to war with Iraq in part because of faulty intelligence about weapons of mass destruction that were never found. Top aides did not want to make a similar mistake. In September 2007, Israel bombed the site.
As Eyder said Wednesday, Cheney is likely to be in the news a lot in coming weeks as more details from his book — which goes on sale Monday — are revealed. Yesterday, we heard that Cheney says he kept a signed resignation letter in a safe, in part because he feared he might become incapacitated by a heart attack or stroke. We also learned that he makes another strong defense of the use of waterboarding in the memoir.
Today, the Times adds that in the book Cheney "divulges a number of conflicts with others in the inner circle," including then-CIA Director George Tenet and Bush's two secretaries of state, Colin Powell and Condoleezza Rice.
Also this morning, NBC's The Today Show airs an interview with Cheney. According to NBC correspondent Jamie Gangel, Cheney believes "heads are going to be exploding all over Washington" as more is learned about what's in his book.