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2-5 April, 2014, 16th International Congress on Infectious Diseases, Capetown, South Africa
The meeting will encompass all of the fields in infectious diseases with particular attention being paid to the major infectious causes of death in Africa and elsewhere, which include AIDS, malaria, TB, pneumonia and enteric infections including typhoid fever and diarrhea. In all of these fields there are exciting interventions underway in Africa, the results of which will be presented in Cape Town. In addition there are major areas of neglected tropical diseases that will be discussed and a particular focus will be on the largely uncounted burden of nosocomial infections in developing countries. The ISID has always had its focus on the global burden of infectious diseases and it is important for us to announce our return to Africa some 20 years after the last meeting of the Society there in Kenya in 1992.
6-10 May 2014, 32nd Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID 2014), Dublin, Ireland
Benefit from an unparalleled educational forum, where you will learn about the newest developments, innovative techniques, and advanced practices in Paediatric Infectious Diseases. ESPID 2014 will include interactive case sessions, platform presentations, educational workshops, networking sessions, meet the professor sessions and more, which will be presented by international experts. This is your opportunity to gain new knowledge in the field of Paediatric Infectious Diseases and exchange new ideas with experts and colleagues from around the world.
7-10 May 2014, HIV in the Americas Congress, Rio de Janeiro, Brazil
This meeting will bring together a scientific programme to explore through plenary sessions, discussion and networking issues of particular relevance to the region. Faculty will be drawn both from within the region and from international experts.
7-25 July 2014, Clinical Global Infectious Diseases course, Aarhus, Denmark
The 3-week summer course in Clinical Global Infectious Diseases will give an introduction to major infectious diseases like malaria, tuberculosis, HIV, yellow fever and others with emphasis on geographical distribution, difference in morbidity and mortality between different parts of the world, clinical signs and symptoms, diagnosis, prevention and control. Advice to travelers will be discussed and appropriate investigations in immigrants will be reviewed. Emphasis will be on the difference in incidence, prevalence, morbidity and mortality between countries and continents. Appropriate control programmes will be discussed, both at national and international level.
20-25 July 2014, AIDS 2014 - the 20th International AIDS Conference, Melbourne, Australia
The International AIDS Conference is the premier gathering for those working in the field of HIV, as well as policy makers, persons living with HIV and other individuals committed to ending the pandemic. It is a chance to assess where we are, evaluate recent scientific developments and lessons learnt, and collectively chart a course forward.
The AIDS 2014 programme will present new scientific knowledge and offer many opportunities for structured dialogue on the major issues facing the global response to HIV. A variety of session types - from abstract-driven presentations to symposia, bridging and plenary sessions - will meet the needs of various participants. Other related activities, including the Global Village, satellite meetings, exhibitions and affiliated independent events, will contribute to an exceptional opportunity for professional development and networking.
25-26 July 2014, Zoonoses 2014, Brisbane, Australia
The Australasian Society for Infectious Diseases is holding a 2 day meeting on the topic of Zoonoses.
Zoonoses 2014 follows on from the highly successful inaugural Meeting that was held in Sydney in July of 2012. This event hosted 232 delegates over 2 days and featured 29 oral and 42 poster presentations from prominent medical and veterinary infectious disease professionals from Australia and overseas.
The theme for the 2014 conference is: "Zoonoses in a Changing World: Two Professions, One Health" and is anticipated to attract a mix of infectious disease physicians and trainees, veterinary officers and veterinarians, microbiologists, laboratory scientists, public health physicians, researchers, policy officers, travel and tropical medicine specialists, epidemiologists, nurses, program managers and other health care professionals.
27 July-1 August 2014, International Union of Microbiological Societies 2014 Congresses, Montreal, Canada
10-12 August 2014, 69th International Conference on Diseases in Nature Communicable to Man (INCDNCM), University of British Columbia, Vancouver, British Columbia, Canada
The 69th Annual Meeting of INCDNCM is being hosted by the BCCDC Public Health Microbiology & Reference Laboratory, at the University of British Columbia, Vancouver, BC.
Zoonotic diseases are the major focus of this two day meeting, which serves as a forum for physicians, scientists, veterinarians, specialists and public health professionals to present their research and findings for discussion and debate. Symposia will focus on emerging diseases such as Lyme disease, arboviral, rickettsial, bacterial and parasitic infections in humans and animals.
Both oral presentations and posters are strongly encouraged from conference registrants, with a strong emphasis on student participation. On-line conference registration will be available shortly together with the conference program at the INCDNCM webpage.
Information on conference registration, preferential accommodation rates at the University, social events, travel and tourism within the city of Vancouver will also be posted on this website.
22-24 Sept 2014, Infectious Diseases in the Mediterranean and the Middle East: Current Challenges, an ESCMID postgraduate workshop, Izmir, Turkey
The course will provide an update on current infectious diseases in the Mediterranean and the Middle East with emphasis on viral, bacterial and parasitic infections with changing epidemiology, diagnosis and management. Viral infections will include the spread of the novel Coronavirus and the avian influenza H5N1 and CCHF. The problems of multiresistant bacteria will be covered both from management and hospital infection control perspectives, and molecular surveillance will be reviewed.
31 October - 3 November 2014, International Meeting on Emerging Diseases and Surveillance (IMED 2014), Vienna, Austria
The threats posed by pandemic influenza, bioterrorism and the realization that new infectious diseases may be recognized at any time, in any place have dramatically raised our awareness and our need to understand emerging pathogens. What are the most important emerging disease threats? What biological, ecological, social and other factors lead to their emergence? How can we quickly detect their occurrences in order to respond in timely and appropriate ways? This meeting will fully embody the "one health" model of emerging diseases, recognizing the commonality of human and animal health.
Email | Website
2-6 November 2014, HIV Glasgow Drug Therapy Meeting, Glasgow, UK
The meeting will provide a relevant, meaningful and topical Scientific Programme reflecting recent progress in the research and treatment affecting the management of HIV infection. This Congress will provide practical advice and guidance to clinicians in the day-to-day treatment of their patients. The programme is being developed to offer a mix of presentation-types and styles from keynote lectures to practical case-based presentations, within a single-session plenary format. Abstract submission is encouraged and abstracts will be considered for oral presentation in the plenary programme or oral poster discussion sessions, as well as printed posters. Time is set aside within the programme to encourage discussion and audience interaction.
16-18 January 2015, International Conference on Infectious & Tropical Diseases (ICTID), Phnom Penh, Cambodia.
The ICTID will focus on infectious and tropical problems in Asia and Africa, and on other global problems such as malaria, tuberculosis, HIV/AIDS, dengue/other viral fevers, melioidosis, schistosomiasis, hemorrhagic fevers, ricketsioses, diarrheal diseases, sepsis, meningitis, respiratory tract infections, avian influenza, neglected infectious diseases, hepatitis and others.
The target public of ICTID are doctors, nurses, pharmacists, laboratory staff, and last year medical students. The number of the participants is limited to 400. Abstracts from scientists all over the world are welcome, and will be published in a separate international medical journal, together with the lectures.
For more information please contact Professor Dr. Georg Gossius or visit http://ictid.webs.com.
26-29 March 2015, 7th International Congress of the Asia Pacific Society of Infection Control (APSIC 2015), Taipei, Taiwan
The Asia Pacific Society of Infection Control (APSIC) was established in 1998 and is a multi-national and voluntary organization dedicated to the advancement of infection control practice to reduce hospital associated infections, monitor and control emerging and re-emerging infectious diseases and improved patient outcomes. After the first international Congress launched under its name in 2001 in Hong Kong, the Congress is now held every two years.


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Effect of broccoli, soy on cancer cells explained
Eating foods like broccoli and soy has been linked to lower cancer rates, and California researchers said on Sunday that they may have discovered the biological mechanism behind the Using cells in a ...
Apr 16 2007 3:29pm
Watch the soy intake if you have had or are at high risk for breast cancer though. Soy wo ...
Katherine B.
Jan 23 2009 6:29pm
Cell Phone Warning
It seems that no matter where you go, there's someone on their cell phone: in the car, the gym, the Laundromat; I've even heard of people answering their phone during sex! I can't think of any call th ...
Heather J.
Jul 08 2007 5:00pm
My story with MS an a bone marrow stem cells transplant
On the road to a bone marrow stem cell transplant in 2006 I was Dx in 2000 at age 28 when I lost my eyesite in my left eye of course. Gained my eyesite back with steroids. ...
Mar 23 2009 2:59am
Well thank you for such kind words! I know I was on the same floor that I did my transp ...
Sep 08 2009 9:32am
Cell Salts
On a hot day when I have been active outdoors, I take a little bit of cell salts. My daughter loves 'em because she can be completely depleted of these bio salts and just shine moments after intakin ...
Kenna M.
Aug 28 2007 8:56am
I am a naturopathic physician and use
Salts all the time successfully on numer ...
Dr. Ben
Feb 26 2009 3:59pm
Superfood Proven to Treat Skin Cancer
We all know that eating healthy, natural foods is good for us, but I was impressed by this study I just read stating that compounds in black raspberries seem to treat skin cancer. Researchers at the ...
Rebecca S.
Jun 04 2007 2:16am
The effects of every day stress, pollution, work, and un healthy eating create major dam ...
Oct 13 2008 3:01pm
Philips 598: The Phone For Weight-Conscious Women
Philips are releasing a cell phone targeted towards women. What's intriguing about the phone is the feature set. The features include both a Body Mass Index calculator and a Basal Metabolic Rate feat ...
Mar 21 2007 12:12pm
Caffeine + Exercise = Reduced Risk of Skin Cancer
According to a new study, exercise and a regular coffee habit might be enough to ward off skin cancer. Researchers from the Laboratory for Cancer Research at the School of Pharmacy at Rutgers Univer ...
Nirmala N.
Aug 02 2007 12:00pm
Nutrients Necessary for a Vegetarian Diet
If you're thinking of becoming a vegetarian, be sure to do it carefully. Sometimes, vital nutrients that are found in meat sources are lacking in vegetarian diets when they lack variety. For exam ...
Nirmala N.
Aug 11 2007 6:50pm
What a horrifically written article. It is far easier to have a bad diet with animal pro ...
Apr 04 2010 10:15pm
A Matter of Fat
Saddlebags, spare tires, muffin tops we've dreamed up as many names for body fat as Starbucks has for coffee. Even as otherwise sensible, well-adjusted adults, many of us spend a huge amount of time d ...
Mar 15 2007 11:09am
Study shows why exercise boosts brainpower
Exercise boosts brainpower by building new brain cells in a brain region linked with memory and memory loss, U.S. researchers reported Monday. Tests on mice showed they grew new brain cells in a brai ...
Mar 22 2007 11:57am
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The Obama administration could be selling out environmental protections in order to cement a complex international trade deal, according to new documents revealed on Wednesday by WikiLeaks. Today, the whistle-blowing organization published the Environment Chapter of the Trans-Pacific Partnership (TPP), a bilateral agreement that has been in the works since 2010 — confirming critics' fears that the plan will be bad news for the planet rks since 2010 — confirming critics' fears that the plan will be bad news for the planet.
The TPP would establish a trade agreement between 12 countries — the U.S., Japan and a number of other Pacific Rim nations. An expansion of the 2005 Trans-Pacific Strategic Economic Partnership Agreement between Brunei, Chile, New Zealand and Singapore, the TPP aims to promote free trade between more nations in a move that would ideally boost each country's economy.
The trade negotiations were cloaked in secrecy, however, until WikiLeaks published the deal's Intellectual Property chapter back in November. At the time, IT specialists voiced concern that the provisions would boost corporate interests over individual rights, much like the disputed anti-piracy bills SOPA and PIPA that were ultimately shut down.
Now, WikiLeaks has unveiled the proposed environmental chapter, and says the Obama Administration's environmental demands are weak:
When compared against other TPP chapters, the Environment Chapter is noteworthy for its absence of mandated clauses or meaningful enforcement measures. The dispute settlement mechanisms it creates are cooperative instead of binding; there are no required penalties and no proposed criminal sanctions. With the exception of fisheries, trade in 'environmental' goods and the disputed inclusion of other multilateral agreements, the Chapter appears to function as a public relations exercise.


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White Sierra High Camp 3 in 1 Jacket
The Good |
The Bad |
The Verdict |
With a zip-out liner that can also be worn alone, the High Camp 3-in-1 is a versatile, acceptably functional jacket at a very reasonable price. While the jacket provides adequate warmth and weatherproofing, it is relatively heavy and less breathable than others in the test. It also lacks many of the resort-specific amenities of others in the test. At the cheapest price of any jacket we tested—you get what you pay for. |
The Mountain 3-in-1's outer shell is a generic polyester twill treated with a DWR coating with a sewn in liner. The zip-out liner is ripstop nylon with a generic synthetic fill. The exterior shell's stitches aren't taped, so they eventually leaked through after a day of wet precipitation on a soggy day on Mount Hood. The exterior shell's liner and the zippers mating the interior and exterior jackets add weight to an already heavy outer fabric, making this a fairly heavy jacket for the warmth it provides. The Mountain 3-in-1's waterproof breathability isn't in the class of the other jackets in the test.
With a zip-out liner, the Mountain 3-in-1 is a more versatile parka than most in the test. If conditions heat up, simply zip out the insulated liner. If things heat up from there, on say a sidecountry hike, however, there are no pit zips to further ventilate the jacket. The hood is large enough to fit over most helmets, but there is no powder skirt and relatively few pockets, none large enough to stash goggles, spare gloves or climbing skins.
If you're shopping for a system jacket, compare this one to Columbia's Ultrachange Jacket, which offers much higher performance but at a significantly higher price.
How We Tested It
Six different testers skied slopes from Whistler to Utah, to Jackson Hole. Wet weather testing went down at Oregon's Mount Hood Meadows.
The products featured in this test have been loaned to the Gear Institute. For more on our policies regarding editorial objectivity and sample returns, see here.
Ready to Purchase?
Retailer |
Product Name |
Price |
Peter Glenn Ski & Sports | White Sierra High Camp 3-in-1 Ski Jacket (Men's) | $129.99 |
Amazon.com | White Sierra Men's High Camp 3-in-1 Jacket, Titanium, X-Large | $110.00 |
Bells & Whistles
Gear Institute Rating (Total Score)
- Pit zips: none
- Waterproof: No
- Powder skirt: None
- Gender: Men's
- Fall 2012


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Hot Water (American Dad!)
"Hot Water" | |||
American Dad! episode | |||
Episode no. | Season 8 Episode 1 |
Directed by | Chris Bennett | ||
Written by | Judah Miller Murray Miller |
Production code | 6AJN18 | ||
Original air date | September 25, 2011 | ||
Guest actors | |||
Episode chronology | |||
List of American Dad! episodes |
"Hot Water" is the first episode and season premiere of the eighth season of the animated comedy series American Dad!. It was aired by Fox on September 25, 2011.
This episode, narrated by Cee Lo Green, is a parody of Little Shop of Horrors. Stressed out by his family and his obligations, Stan allows Principal Lewis to take him shopping for a hot tub at the Little Shop of Hot Tubs. Stan is drawn to a used hot tub in the store's back room that the salesman, Margarite, tries to talk him out of purchasing. Stan ignores him, buying the hot tub and taking it home with him. There, he learns that the hot tub can talk, tempting Stan into using it (Dip a Toe). This eventually leads to him and Francine having their most intense sex ever (Hot Tub of Love).
Francine starts to worry about the hot tub's effect on Stan, and orders him to stay out of it. That night, the tub draws Stan to it, leading Francine to give Stan an ultimatum: the tub or her (Do Whatever You Like). When Stan chooses the tub, Francine packs the rest of the family and leaves for her parents' house (Daddy's Gone). Still unable to shake his suspicions about the hot tub, Margarite investigates its past, learning that it came alive after being struck by lightning and killed its original owner. It later escaped from a mental hospital (Research).
Margarite and Principal Lewis go to Stan's house, where the hot tub swallows Lewis and causes an escaping Margarite to crash his car, killing him. The hot tub then draws Francine back home, imitating Stan on the phone. Stan discovers the deception and returns home just as the hot tub swallows Francine. After the hot tub explains its first killing spree, Stan unsuccessfully tries to recover Francine. The hot tub jettisons Stan through the roof, leaving him sprawled on the pavement across the street (Psychotic Hot Tub).
At the last moment, Stan remembers the "Spa Down" given by Margarite for "calming down" his tub; unfortunately, he succumbs to his wounds. Cee Lo announces that Stan is dead, ending the episode abruptly.
This episode was written by Judah Miller and Murray Miller and directed by Chris Bennett. This would be the second season premiere to be written by the Millers, the first being "In Country...Club".
During the "Evening with American Dad" panel with the show's staff that took place at the Paley Center on September 22, 2011, executive producer Mike Barker revealed that there was a time that they thought that the show was not going to be renewed and thought that this was going to be the final episode. To quote Barker: "We thought, 'What better way to end the series? Kill the main character!'"[3] The songs and music score were written and composed by Asa Taccone, brother of Jorma Taccone from The Lonely Island fame.
The music in the episode was by Asa Taccone of Electric Guest.
The A.V. Club graded the episode a B+, stating "This wasn't, perhaps, the gut-bustingly funny American Dad that the show can be at its best, but audacity in musical form is just about as good. American Dad used tonight's season premiere to establish itself as the weird middle sibling of the Fox animated shows. Right now, it's probably also the best of them".[4]
This episode was nominated for a Primetime Emmy Award, but lost to the Penguins of Madagascar episode, "The Return of the Revenge of Dr. Blowhole".
- ^ http://www.foxflash.com/div.php/main/page?aID=1z2z2z28z4z5
- ^ http://www.thefutoncritic.com/listings/20110902fox18/&date=09/01/2011&filter=premieres
- ^ http://www.hulu.com/watch/282278/american-dad-an-evening-with-american-dad-
- ^ Kaiser, Rowan (2011-09-25). ""Hot Water"". The A.V. Club. Retrieved 2011-10-03.


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What a great job!! I love doing projects like this... cant wait to have my garage back because I usually grab stuff for free on craigslist and give them a second life.
here is a desk I found and its sitting in my daughter's room.
I love wooden furniture... your paint job looks amazing!
I actually think your design looks much better then the original! :)


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Analysis of trends in technical and allocative efficiency: An application to Texas public school districts
No abstract is available for this item.Download Info
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Bibliographic Info
Article provided by Elsevier in its journal European Journal of Operational Research.
Volume (Year): 154 (2004)
Issue (Month): 2 (April)
Pages: 477-491
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Web page: http://www.elsevier.com/locate/eor
Related research
References listed on IDEASPlease report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Rajiv D. Banker, 1993. "Maximum Likelihood, Consistency and Data Envelopment Analysis: A Statistical Foundation," Management Science, INFORMS, vol. 39(10), pages 1265-1273, October.
- Banker, Rajiv D & Maindiratta, Ajay, 1988. "Nonparametric Analysis of Technical and Allocative Efficiencies in Production," Econometrica, Econometric Society, vol. 56(6), pages 1315-32, November.
- Gyimah-Brempong, Kwabena & Gyapong, Anthony O., 1992. "Elasticities of factor substitution in the production of education," Economics of Education Review, Elsevier, vol. 11(3), pages 205-217, September.
- Cohn, Elchanan & Rhine, Sherrie L W & Santos, Maria C, 1989. "Institutions of Higher Education as Multi-product Firms: Economies of Scale and Scope," The Review of Economics and Statistics, MIT Press, vol. 71(2), pages 284-90, May.
- Richard J. Butler & David H. Monk, 1985. "The Cost of Public Schooling in New York State: The Role of Scale and Efficiency in 1978-79," Journal of Human Resources, University of Wisconsin Press, vol. 20(3), pages 361-382.
- Chizmar, John F & Zak, Thomas A, 1983. "Modeling Multiple Outputs in Educational Production Functions," American Economic Review, American Economic Association, vol. 73(2), pages 17-22, May.
- Subhash C. Ray, 1991. "Resource-Use Efficiency in Public Schools: A Study of Connecticut Data," Management Science, INFORMS, vol. 37(12), pages 1620-1628, December.
- Ahn, Taesik & Charnes, Abraham & Cooper, William W., 1988. "Some statistical and DEA evaluations of relative efficiencies of public and private institutions of higher learning," Socio-Economic Planning Sciences, Elsevier, vol. 22(6), pages 259-269.
- Banker, Rajiv D. & Chang, Hsihui, 1995. "A simulation study of hypothesis tests for differences in efficiencies," International Journal of Production Economics, Elsevier, vol. 39(1-2), pages 37-54, April.
- Eric A. Hanushek, 1979. "Conceptual and Empirical Issues in the Estimation of Educational Production Functions," Journal of Human Resources, University of Wisconsin Press, vol. 14(3), pages 351-388.
- Hanushek, Eric A, 1986. "The Economics of Schooling: Production and Efficiency in Public Schools," Journal of Economic Literature, American Economic Association, vol. 24(3), pages 1141-77, September.
Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.Cited by:
- Haelermans, Carla & Ruggiero, John, 2013. "Estimating technical and allocative efficiency in the public sector: A nonparametric analysis of Dutch schools," European Journal of Operational Research, Elsevier, vol. 227(1), pages 174-181.
- Justo de Jorge Moreno & Daniel Santín, 2010. "Determinantes de la eficiencia educativa en la Unión Europea," Hacienda Pública Española, IEF, vol. 193(2), pages 131-156, June.
- Haelermans, Carla & De Witte, Kristof & Blank, Jos L.T., 2012. "On the allocation of resources for secondary schools," Economics of Education Review, Elsevier, vol. 31(5), pages 575-586.
- M. C. Portela & A. S. Camanho, 2007. "Performance Assessment of Portuguese Secondary Schools," Working Papers de Economia (Economics Working Papers) 07, Faculdade de Economia e Gestão, Universidade Católica Portuguesa (Porto).
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text:
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i do alot of parts ordering on line and i know when i use partsgeek i will get a good part at agood price and most important fast shipping.parts always arrive in good condition. thanks partsgeek. ...
Good description of part made ordering quick and easy. I received the part in a few days with regular ground shipping. I'm very pleased.


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Order by 3:00PM EST Monday-Friday for SAME DAY shipping from SportStop.com in NH
Found this cheaper? Click here to request a price match
Dimensions: 17.5"H x 15.5"W x 6.5"D
Things I Liked:
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Full Review:
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Spacious and looks cool
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Comfortable straps Plenty of room Fits close to body making it easier to move around on the school bus.
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My Blog
Hi :D My name is Amela (female) and I'm 13 years old :D I love music and dancing :D That's why you will mostly find Skrillex,deamau5,Daft Punk, Metallica,Poreotics,I aM mE,Quest Crew pictures,gif etc. :D ;) I also love Lord of Rings,Star Trek,playing games,physics,my guitar and all similar stuff :D |
OMG OMG OMG OMG OMG OMG I can't breathe :D :D TOTAL HAPPINES!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
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Tagged as: Chad Mayate, twitter, OMG!!!, best thing ever that happend in my life, Poreotics, (Source: tylerlikespurple, via wearegoinghome) (Source: wasabi-desu, via fuckingfunny) (Source: dr3am-ab0ut-tomorr0w, via cuthroatdiva)
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1.Harry 2.London 3.Danielle 4.1 kid 5. DANCER (!!! YESS!!!) 5. 3rd :D (via dancealongs) Facebook: MEANWHILE ON TUMBLR: LOGGING IN: FUNNY POSTS ON YOUR DASH: DELICIOUS FOOD ON YOUR DASH: SEXY PEOPLE ON YOUR DASH: TALKING TO YOUR FAVOURITE BLOGGERS: HATERS IN YOUR ASK: FOLLOWERS PWN YOUR HATERS: IDIOT FACEBOOK USERS: ERRORS: LOSE A FOLLOWER: GAIN A FOLLOWER: FAVOURITE BLOG FOLLOWS BACK: START GETTING TIRED: STAY ONLINE ANYWAY: ULTIMATELY. TUMBLR = NEVER BORED. THIS^ (Source: , via owsl4) (via owsl4) THis was the scene when I seriously cried :'( It was the sadest scene in the movie… :'( (via rat0nhnhaketon) (via le-dafthouse-with-skrillmau5-de) and BÄMM…they come back with a huge carpet…WTF??!! (Source: sincerelytumb1r, via owsl4) Theme by;sexxiemonsta http://26.media.tumblr.com/tumblr_lvceu3q4Af1r79022o1_500.gif |


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GAME REPORT Rangers 8, San Diego 4 Jurickson Profar hit a grand slam on the first pitch from minor-league RHP Dennis O'Grady to key a six-run sixth inning during the Rangers' victory at Peoria, Ariz. It was the Rangers' first … Continue reading
Category Archives: Uncategorized
Engel Beltre in and out of Texas Rangers lineup
PEORIA, Ariz. — Outfielder Engel Beltre, whose future with the Texas Rangers rides on his performance this spring, was scratched from the lineup for the second time in three days on Thursday because of left shin splints. The problem arose … Continue reading
Joe Saunders set for debut with Texas Rangers
SURPRISE, Ariz. — The Texas Rangers went into the hurry-up mode with newly acquired left-hander Joe Saunders. The original plan was for Saunders, who signed on Wednesday, to throw at least one batting-practice session before appearing in a game. Upon … Continue reading
Engel Beltre returns to Texas Rangers lineup
SURPRISE, Ariz. — Outfielder Engel Beltre, in the midst of a vital spring training, will be back in the Texas Rangers' lineup for Thursday's game against San Diego at Peoria, Ariz. Beltre was scratched from the lineup on Tuesday because … Continue reading
Rangers finally get good news on pitching front: Oft-injured left hander staying healthy
The club is in its third week of spring training, and left-hander Rafael Perez has yet to appear on the injury report because of shoulder problems. For Perez, that represents a step forward. "I feel better than I have in … Continue reading
Rangers have Mitch Moreland on different program than other veterans, creating more work for him
Mitch Moreland is on a different program than other veterans. The normal plan calls for a veteran to play two days and get one day out of the lineup. Moreland plays three consecutive days before a break as Washington prepares … Continue reading
Elvis Andrus plays against Colorado, gives update on forearm tendinitis
SURPRISE, Ariz. — With one throw Wednesday, shortstop Elvis Andrus eased the Rangers' concerns about his health. Andrus went into the hole to reach a grounder by Paul Janish and made a pain-free throw to first to get the final … Continue reading
Texas Rangers offense sputters as they get dominated by split-squad club
GAME REPORT Colorado 8, Rangers 2 Colorado, using a split-squad team, broke open a close game with six runs in the seventh inning to defeat the Rangers at Surprise, Ariz. LHP Neal Cotts started the inning and retired only two … Continue reading
Russell Wilson's No. 3 Texas Rangers jersey among MLB's best selling
It's unlikely that Seattle Seahawks quarterback Russell Wilson will ever play for the Texas Rangers. But that doesn't mean fans won't purchase Rangers jerseys with his name on the back. In case you haven't heard, Wilson, fresh off leading the … Continue reading
Texas Rangers listed in latter half of top ten in terms of favorites to win World Series
Bovada, an on-line betting service, listed the Texas Rangers and San Francisco as the eighth choice to win the World Series. The odds on the clubs are 16-1. The Los Angeles Dodgers are the morning-line favorite at 13-2. Houston is … Continue reading
Joe Saunders ready to go with Texas Rangers: 'I feel like I'm right on track'
SURPRISE, Ariz. — The Texas Rangers made the signing of left-hander Joe Saunders official on Wednesday morning, but he began his stay with the club on Tuesday by throwing batting practice to minor-league hitters. Saunders received a non-guaranteed one-year contract. … Continue reading
Elvis Andrus back in Texas Rangers lineup
SURPRISE, Ariz. — Shortstop Elvis Andrus was cleared to play for the Texas Rangers and will start on Wednesday against Colorado. Andrus had missed the previous four games because of forearm tendinitis. The Rangers' lineup: LF Shin-Soo Choo SS Elvis … Continue reading
Replay era begins poorly for Rangers
The Rangers began the replay era with a failed challenge during a 7-4 loss to the Angels. Manager Ron Washington made his first challenge in the seventh inning on a stolen base by J.B. Shuck. Washington thought second baseman Kensuke … Continue reading
Texas Rangers exhibition report: Angels 7, Rangers 4 as late-inning subs fail again
TEMPE, Ariz. – As has been the case early this spring an opponent took advantage of the Rangers' lack of depth late in games. The Angels scored five runs over the sixth and seventh innings to take a win. It … Continue reading
Darvish, Trout renew budding rivalry
TEMPE, Ariz. – Rangers right-hander Yu Darvish started a guessing game with Los Angeles Angels standout Mike Trout on Tuesday. With Darvish throwing all fastballs, Trout lined out hard to left and singled. It will be different in the regular … Continue reading


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New York Yankees slugger Alex Rodriguez -- baseball's highest-paid player-- is reportedly facing a 100-game suspension from Major League Baseball if found to have used performance-enhancing drugs. About 20 athletes, including Milwaukee Brewer and University of Miami alum Ryan Braun, will reportedly ... More >>
The Miami Heat are in Milwaukee to resume their first-round best-of-seven series against the Bucks. Games 3 and 4 will be played at the BMO Harris Bradley Center tonight and Sunday.But according to 790 the Ticket's morning radio show, the Heat has decided to stay at a different hotel than usual. Pri ... More >>
On Tuesday, a week and a day after Miami New Times published online a report describing hundreds of pages of records from the office of a Coral Gables clinic, Biogenesis, the first professional baseball players have acknowledged involvement with owner Anthony Bosch. In statements issued Tuesday to ... More >>
The news in Broward and Palm Beach this Tuesday morning:An internal report concludes that Broward Sheriff Al Lamberti's agency has neglected measures meant to increase diversity. The sheriff is already being criticized for steering layoffs toward jail staff, which is dominated by minority deputie ... More >>
There are many theories but only one truth: good music
April 29 - May 5, 1999


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Lira \l(i)-ra\ as a girl's name is a variant of Elvira (Old German), and the meaning of Lira is "foreign, true".
The baby name Lira sounds like Lara, Lora, Liora, Liri, Lura and Lyra. Other similar baby names are Lina, Lita, Lida, Mira, Cira, Lila, Nira, Eira, Liza, Lisa, Kira, Lia, Liya, Liba, Liva and Uira.
Lira is not a popular first name for women but a very popular surname or last name for all people (#3308 out of 88799). (1990 U.S. Census)


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1 result for DIANAROSSMARTIN from older pre-Shortz puzzles.
Date | Grid | Clue | Author | Editor |
Thursday, December 22, 1988 | 36A | Songstress joins actor | Bernice Gordon | Maleska |


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France >
Provence >
Vaucluse >
Free Breakfast
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Free Parking
Pets Allowed
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Ranked #1 of 11 B&Bs / Inns in Mazan
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- La Bastide de Brurangère is a prestigious guest located in Provence, at the feet of Mont Ventoux We welcome you in our 3 luxury suites for 2 or 4 people, and 2 spacious rooms with the best comfort and equipments. Our SPA and double pool will seduce and refresh you in the hot Provence summer ! ... more less


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Monteith Autopsy Scheduled, Brown Faces Charges
Description:An autopsy was scheduled for "Glee" star Cory Monteith on Monday (July 15). The 31-year old actor died over the weekend in a Vancouver hotel room. So far, there have been no details on the cause of death, but Monteith had sought help multiple times for a drug addiction. A rep for Lea Michele, Monteith's co-star and girlfriend, released a statement asking that the media respect her privacy. (1:24)
Source: Reuters
Tags: reuters , reuters news , adam sandler , Chris Brown


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How apps are changing fast food
The world of fast food is getting faster and redefining the future of mobile payments
Computerworld - No need to "run for the border" when you want a gordita or a chalupa. Taco Bell lets you place orders with a smartphone app. The fast-food chain is testing a mobile phone-based ordering system at five Southern California locations, with plans to expand nationwide by the end of the year.
The app does what you might expect. It shows the complete menu, with all options on each item. You can choose exactly what you want before you get to the restaurant. When you arrive, you simply pick up your order. And because your credit card is registered with the app, your food will already be paid for when you pick it up.
Plus, the app does some neat tricks you might not expect. For example, you can place an order even if you're too far away to pick it up quickly. The GPS in your phone will notify the restaurant when you get close, alerting the staff to start preparing your order.
You can pick up your order either inside the restaurant or at the drive-through window.
The app is also mildly contextual. Its interface changes depending on the time of day. Pricing defaults to the menu of the nearest location. It also gives you directions to that location.
Taco Bell has been developing the app for two years, according to reports.
Why fast food?
The fast-food industry is perfect for this kind of application. The reason is that fast-food menus are highly standardized -- even the options (hold the pickle, hold the lettuce, etc.) are standardized.
When you walk into a restaurant and order, the cashier behind the counter presses preset buttons on a big pad. The ordering system that has been in place for decades is easily replicated by a mobile app, resulting in the same outcome -- a printout or a screen display showing the complete order for the food assembly workers.
The other component of a fast-food register, of course, is the point-of-sale system -- something also replicable with an app.
Essentially, what's happening is that cashiers are being replaced by apps. And why not? Why do you need a teenager to press buttons on a screen and process your credit card when you can press your own buttons on your own screen and process your own credit card?
An app also works like a loyalty card. Once you install the app, you're more likely to use it -- and you're more likely to patronize the restaurant.
Everybody's doing it
Chipotle Mexican Grill is way ahead of Taco Bell. It has an app that's already usable at all of its locations. Just order your meal, then pick it up. You can even save your favorite meals for easy re-ordering later.
Mobile payments
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As emerging technologies evolve they often find an initial niche in highly specialized scenarios, or in specific industry verticals, before expanding to wider areas of applicability. Within these initial niches, the early adopters can be anything from digital enthusiasts to fashionistas, or they can be folks simply using the technology because it serves a specific need extremely well. (free registration required) more


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CBS' Leslie Moonves Jokes About Angus T. Jones Controversy
UPDATED: At an investor conference, he talks about the "Two and a Half Men" actor's video rant, fall TV ratings, Netflix and retransmission fees.
NEW YORK -- CBS Corp. president and CEO Leslie Moonves on Tuesday again touted his company's growing retransmission-fee revenue and new licensing money from Netflix, while arguing that weaker ratings for the new TV season are due mostly to special factors and measurement systems that don't fully capture audiences on new platforms.
Speaking at the 40th UBS Global Media and Communications Conference here, he also joked about Two and a Half Men actor Angus T. Jones' recent rant. As part of a broader discussion of the company's management of costs and its network, he mentioned "that kid on Two and a Half Men who makes $300,000 per episode to talk bad about me."
The actor had said Christians should "please stop watching" watch his show because it is "filth."
Moonves later said he continues to like the Simon & Schuster book unit, which some believe could be looking at merger. The exec lauded its digital transformation and its financial success before quipping that it is also a prestigious but low-profile business. "I don't have any kids calling me filthy in the publishing [space]," he joked in another reference to the Jones controversy.
At a breakfast event earlier Tuesday, Moonves was asked if Jones' apology would be good enough to keep him on the show. "I don't know what our status is with him," Moonves replied, according to Forbes. "I don't think it's been quite resolved, but after going through what we went through with Charlie Sheen, it's been a piece of cake."
Moonves added: "It seems to be what happens with child stars over time. We took this boy who started with us when he was 8 years old. Now's he's making over $300,000 per week, which is not a bad salary for a 19-year-old kid. By the way, he's still collecting his $300,000 per week."
Back at the UBS conference, Moonves was asked about Monday comments from Time Warner Cable CEO Glenn Britt that his pay TV giant would drop weaker-performing TV networks or move them to lower carriage tiers. Moonves said that this must mean Britt would pay more for channels that do get viewed. Distributors "should pay more for the No. 1 network," he said. "You should pay for the eyeballs."
Highlighting that ESPN gets $4-plus per subscriber per month in fees, Moonves quipped that "we're going in next year for $7" with CBS. He declined comment on the continued bundling of cable networks in pay TV carriage deals. Time Warner CEO Jeff Bewkes earlier in the day had defended bundling.
Discussing the weaker start to the fall TV season, Moonves said Nielsen needs to improve its measurement of viewing on new platforms. "A lot of streaming, VOD and SVOD is not reported properly," he said, predicting that within a year and a half ratings measurements and discussions will switch to audience data that includes the first seven days of viewing.
While he said he gets up at 5 a.m. every day and looks at the overnight ratings, those are less and less significant, Moonves said. Asked about the reasons for the weaker TV ratings so far this season, he called them "a bit of an aberration."
" The DVR is much more significant than ever before," he said, and VOD and new online options for viewing add eyeballs over time. New CBS drama Elementary, for example, only gets about 60 percent of its viewership from the live audience.
He also cited the political debates and elections and new Thursday night football broadcasts on the NFL Network as key drivers of the lower ratings.
Moonves on Tuesday also reiterated that by 2017, his company will bring in more than $1 billion in retransmission revenue. He lauded that along with new digital revenue streams from the likes of Netflix and Amazon as key drivers of his company's more diversified revenue.
Moonves once again lauded CBS' content deal with Netflix, signaling that it was likely to extend it beyond its second year. With CSI in its 12th season and winning its time slot, the network could consider making all other 11 seasons available on Netflix if usage data shows that this would make sense, he said.
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Helena Road Neighbors and Face book
We did it! Total of 52 gloves given to Dorothy Day Center in Saint Paul Minnesota! As you can tell its -20 degrees right now and all of your donations have given gloves to 52 men, women and children that would not have them otherwise. Thank you guys for this snowball affect that started on Friday. You made this possible! Special thanks to Menards (on University Avenue) General Manager Tim and his assistance!
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Merely Players is a non-profit theatre group 501(c)(3) just taking off the ground in the four-corners, Colorado area.
Launching Merely Players and The Shape of Things
A message from Mona Wood-Patterson and Charles Ford:
We are thankful and incredulous that, through your generosity and belief in us, we have already surpassed our published goal. We would love to be able to fund many more shows after this one, and we would be honored if those of you who haven't pledged will continue to kick in some money. We figure this Kickstarter fundraiser is a one-time shot, and it could set us up to become self-sustaining for the future. Thank you beyond belief!
As the theatre directors at Durango High School in Durango, Colorado we were suddenly presented with a buy-out opportunity to retire. After a lot of soul-searching, we grabbed it and are now preparing to launch into the next phase of our lives. Quitting a job when you still love it is both a wonderful and a terrible thing. But, we decided to take the risk – to see what else is out there. Act One was our childhood and education, Act Two was our career at DHS. This is our Act Three.
We would love to continue to make theatre in the Durango area, and we are about to see if Durango is willing to support diverse theatre that is always high quality, sometimes edgy, and often in a found space. So we are back with our theatre company, Merely Players. We believe that we can fill a need here in Durango, where most theatre is youth and family oriented. Not that we have anything against youth or families! But isn't it about time that we get some contemporary plays here in some different environments? Plays that leave you thinking ---- plays that tap into the emotions --- plays that require accomplished acting, plays that shake it up a bit here in the old Four Corners~
One such play is Neil LaBute's THE SHAPE OF THINGS. It's an edgy exploration about how life and art are intertwined, posing the question: Is it okay to create even if it might destroy?
We have a venue – a nifty little space behind a dance studio here in town. We have actors – several DHS alum who are now acting professionally. We have passion, which we have put that to use for years in what has largely been our community service when we worked at DHS and which we now want to redirect into other dynamic theatrical projects.
But, alas, we don't have money. As anyone who has ever produced theatre will tell you, it's an expensive art form (especially when Charles Ford is the designer!) We didn't know we were leaving DHS, and we didn't have time to write any grants. So, we are asking our friends, former students, and audience members to help us launch this unique and exciting venture. The money we get from this Kickstart will go toward rent for the space, royalties for the play, salaries for the actors, and future endeavors.
Our long-term goals include making more theatre after this play, being able to pay our actors and technicians, continuing with our education outreach and intern programs, and becoming a vital part of the arts scene here in the region.
It's tricky to know how much money to ask for, because we don't get any of the donations if the Kickstarter project isn't fully funded. So, we're gonna go low here. But, please know that we will happily take any amount, and we guarantee that every dime will go toward making quality theatre. We know that a lot of people in the arts ask for money, and that you have a lot of choices about where to spend your entertainment dollar. And we know that you don't necessarily have a lot of money. We would be honored by any amount that you can give – seriously, it all adds up! We are a non-profit 501 (c) (3) organization, so your donation is tax deductible.
So, if you can help us, we would be thrilled. And, if not, please keep us in your thoughts and send us best wishes so that we can make this thing work! Thank you, thank you, thank you from Mona and Charles (a.k.a. WP and Ford)
THE SHAPE OF THINGS plays at 7:00 P.M. July 21, 22, 23, 37, 28, 29, and 30 at The Back Space Theatre, 1120 Main Avenue in Durango.
"All the world's a stage
And all the men and women
Merely players." --- William Shakespeare
Find us at www.merelyplayers.us
Have a question? If the info above doesn't help, you can ask the project creator directly.
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- Website: merelyplayers.us
Pledge $1 or more
You selected3 backers
If you pledge $1 - $19: You get listed as a Kickstarter in our program for THE SHAPE OF THINGS.
Pledge $20 or more
You selected12 backers
If you pledge $20-$49: Not only do you get listed as a Kickstarter in our program for THE SHAPE OF THINGS, you can write a personal message of one sentence to be printed in our program. This can be a dedication, a message to someone in Durango, a political view, a quote--- just think of the possibilities! (Of course, it's gotta be appropriate, gang, so it's subject to our censorship)
Pledge $50 or more
You selected17 backers
If you pledge $50-$99: You still get the message option, you'll be listed as a Contributor in the program, and you receive 2 tickets for the play if you'll be in town then or want to give them to someone.
Pledge $100 or more
You selected8 backers
If you pledge $100-$249: You still get the message option (only now you get 2 sentences – hoorah!), you'll be listed as a Supporter in the program, and you receive 4 tickets for the play if you'll be in town then or want to give them to someone.
Pledge $250 or more
You selected2 backers
If you pledge $250-$499: You still get that great two sentence message option, you'll be listed as a Backer in the program, and you receive 4 tickets for the play if you'll be in town then or want to give them to someone. And we'll send you a photo of the play.
Pledge $500 or more
You selected0 backers
If you pledge $500-$999: Hey, now you can have 3 sentences! You'll be listed as a Sponsor in the program, and you receive 10 tickets for the play if you'll be in town then or want to give them to someone. We'll send you a photo of the play. We'll post a special thank you video on You-Tube. We'll send you our love. You'll be our friend forever.
Pledge $1,000 or more
You selected0 backers
If you pledge $1000 or more: You can have a whole paragraph and up to 30 tickets. You'll be listed as a Benefactor in the program. We'll put in advertising, if you so desire. You get the photo and the personalized thank you video on You-Tube. The love is a given, and the friendship even goes into the hereafter.
Funding period
- (23 days)


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Hump Day's lineup looks something like this:
Tomorrow's Thursday--almost there! Until then, ROCK!
(News credit to 411mania.com and Kotaku.com)
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Shocking Washington Post Story Reveals That Journalistic Ethics 'Amuse' Nick Denton
The Washington Post was really asking for it when, for a straight-faced story about paying sources for information, they talked to Gawker media overlord Nick Denton. The conversation consisted of "an exchange of electronic messages."
"I'm content for the old journalists not to pay for information. It keeps the price down," Denton electronically Read More


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PHOENIX -- "In general, pastors are less informed about the culture in which they live than are the people in their churches," according to research released by LifeWay Christian Resources of the Southern Baptist Convention.
Research released in the November/December edition of LifeWay's Facts & Trends magazine delves into how informed Protestant ministers and laypeople see themselves in regard to 12 facets of today's culture: books, music, sports, celebrities, television programs, politics, magazines, radio & TV talk shows, movies, the Internet, video & computer games, and clothing & fashion.
Two studies were conducted for Facts & Trends by Ellison Research in Phoenix: a representative sample of 797 Protestant church ministers nationwide and a companion survey of 1,184 adults who attend Protestant churches at least once a month. The studies asked each group to rate whether they are very informed, somewhat informed, not very informed or actively avoid the various facets of popular culture.
Not one of the 12 categories registered a majority of clergy or laity as very informed about culture. Pastors and churchgoers rarely try to avoid popular culture, but they tend to see themselves as relatively uninformed.
Ministers tend to stay most informed about politics, with 36 percent saying they are very informed about the subject and another 55 percent saying they are somewhat informed. This is the only category in the study about which ministers feel better informed than the laity, with 29 percent of all churchgoers feeling very informed about politics and another 47 percent feeling somewhat informed.
Pastors and laypeople feel about equally informed on sports. Twenty-four percent of clergy feel very informed about sports and another 44 percent are somewhat informed about this topic, with similar percentages stated by churchgoers.
On each of the other 10 topics, ministers feel significantly less informed about the culture surrounding them than do churchgoers. Twenty percent of ministers feel very informed about the Internet compared to 43 percent of laity; 19 percent of ministers feel very informed about what's on television today compared to 31 percent of laity; 18 percent are very informed about books compared to 27 percent of laity; and 16 percent are very informed about movies today compared to 24 percent of laity.
Pastors rarely feel very informed about the other culture topics on the survey: radio and TV talk shows (12 percent versus to 20 percent among laity); music (11 percent versus 28 percent among laity); magazines (11 percent versus 17 percent among laity); clothing and fashion (7 percent versus 16 percent among laity); video and computer games (5 percent versus 16 percent among laity); and celebrities (4 percent versus 10 percent among laity).
The areas where the greatest gaps exist between pastors and churchgoers are in video & computer games, and fashion & celebrities. Fifty-nine percent of ministers are uninformed about fashion compared to 37 percent of the people in the pews; 69 percent are uninformed about celebrities compared to 49 percent of laity; and 71 percent are uninformed about video and computer games compared to 49 percent of laity.
Among ministers, there were no dramatic differences among denominational groups (Methodists, Baptists, etc.). In general, mainline ministers tend to feel slightly more informed about books and movies than do evangelical pastors, but the other findings are quite similar.
There are some differences according to age, however. Younger ministers (under 45) feel more informed about sports, the Internet, music, clothing and fashion, celebrities and video and computer games than do older ministers. However, this is also true among the people attending their churches – younger churchgoers feel much more informed about these areas and others in today's culture than do older people.


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I had a door to door insulation salesman come in and quote a price for attic insulation. I signed a contract under the understanding that I could cancel up to the time of installation. I called to cancel twice because upon review I did not qualify for the rebates. I was assured I did qualify and the contractor would refund the difference of anything I didn't recover in rebates. When the contractors showed up the next day they did not provide a copy of the contract, failed to show ID, liked about identities (told us he was the twin brother of the salesman from day before) and we quickly realized we would not be getting any rebates. We feel the Colorado Consumer Protection Act was violated. We still do not have a copy of any contract. Looking for help to defend in small claims.
If you have been sued, speak with an attorney immediately. You have a defense of rescission if you gave notice in the time required. I can only hope you did this in writing. Regardless, email an attorney on this site to discuss this matter and see if they can advise or represent you.
Now, given this is small claims, it does not make sense to pay an attorney for a full representation. You can still see if any would advise you under a limited representation. Good luck.


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Neuron, Volume 69, Issue 2, 27 January 2011, Pages 188-190
Courtney A. Miller
SummarySome adults fail to adapt to chronic stress, developing symptoms of depression and anxiety. In this issue of Neuron, Uchida and colleagues link maladaptive stress responses to GDNF through a comprehensive investigation of the neurotrophic factor's regulation. Further, this study is an excellent example for investigators interested in neuroepigenetics research.
Summary | Full Text | PDF (223 kb) - Gdnf Haploinsufficiency Causes Hirschsprung-Like Intestinal Obstruction and Early-Onset Lethality in...
Gdnf Haploinsufficiency Causes Hirschsprung-Like Intestinal Obstruction and Early-Onset Lethality in Mice
The American Journal of Human Genetics, Volume 70, Issue 2, 1 February 2002, Pages 435-447
Liya Shen, José G. Pichel, Thomas Mayeli, Hannu Sariola, Bai Lu and Heiner Westphal
AbstractHirschsprung disease (HSCR) is a common congenital disorder that results in intestinal obstruction and lethality, as a result of defective innervation of the gastrointestinal (GI) tract. Despite its congenital origin, the molecular etiology of HSCR remains elusive for >70% of patients. Although mutations in the c-RET receptor gene are frequently detected in patients with HSCR, mutations in the gene encoding its ligand (glial cell line–derived neurotrophic factor [GDNF]), are rarely found. In an effort to establish a possible link between human HSCR and mutations affecting the Gdnf locus, we studied a large population of mice heterozygous for a Gdnf null mutation. This Gdnf+/− mutant cohort recapitulates complex features characteristic of HSCR, including dominant inheritance, incomplete penetrance, and variable severity of symptoms. The lack of one functioning Gdnf allele causes a spectrum of defects in gastrointestinal motility and predisposes the mutant mice to HSCR-like phenotypes. As many as one in five Gdnf+/− mutant mice die shortly after birth. Using a transgenic marking strategy, we identified hypoganglionosis of the gastrointestinal tract as a developmental defect that renders the mutant mice susceptible to clinical symptoms of HSCR. Our findings offer a plausible way to link an array of seemingly disparate features characteristic of a complex disease to a much more narrowly defined genetic cause. These findings may have general implications for the genetic analysis of cause and effect in complex human diseases.
Abstract | Full Text | PDF (807 kb) - gdnf Activates Midline Repulsion by Semaphorin3B via NCAM during Commissural Axon Guidance
gdnf Activates Midline Repulsion by Semaphorin3B via NCAM during Commissural Axon Guidance
Neuron, Volume 75, Issue 6, 20 September 2012, Pages 1051-1066
Camille Charoy, Homaira Nawabi, Florie Reynaud, Edmund Derrington, Muriel Bozon, Kevin Wright, Julien Falk, Françoise Helmbacher, Karine Kindbeiter and Valérie Castellani
SummaryThe Neurotrophic factor gdnf plays diverse developmental roles, supporting survival and also acting as a chemoattractant for axon and cell migration. We report that in the developing spinal cord, a focal source of gdnf is present in the floor plate (FP) where commissural axons cross the midline. Gdnf has no direct guidance properties but switches on the responsiveness of crossing commissural growth cones to the midline repellent Semaphorin3B by suppressing calpain-mediated processing of the Sema3B signaling coreceptor Plexin-A1. Analysis of single and double mutant mouse models indicates that although gdnf is the principal trigger of Sema3B midline repulsion, it acts with another FP cue, NrCAM. Finally, genetic and in vitro experiments provide evidence that this gdnf effect is RET independent and mediated by NCAM/GFRα1 signaling. This study identifies a regulator of midline crossing and reveals interplays between Semaphorin and gdnf signaling during axon guidance.
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Copyright © 2011 Elsevier Inc. All rights reserved.
Neuron, Volume 69, Issue 2, 359-372, 27 January 2011
Add/View Comments (0)Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events
Shusaku Uchida1, , , Kumiko Hara1, Ayumi Kobayashi1, Koji Otsuki1, Hirotaka Yamagata1, Teruyuki Hobara1, Takayoshi Suzuki2, Naoki Miyata2 and Yoshifumi Watanabe1, ,
1 Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan
2 Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan
Corresponding author
► Stress-induced impairment of GDNF synthesis increases depression-related behaviors ► HDAC2 is required for stress-induced Gdnf repression and behavioral deficits ► DNA methylation is required for stress-susceptible and stress-resilient phenotypes ► MeCP2-HDAC2 complexes contribute to stress-induced Gdnf repression
- Stressful events during adulthood are potent adverse environmental factors that can predispose individuals to psychiatric disorders, including depression; however, many individuals exposed to stressful events can adapt and function normally. While stress vulnerability may influence depression, the molecular mechanisms underlying the susceptibility and adaptation to chronic stress within the brain are poorly understood. In this study, two genetically distinct mouse strains that exhibit different behavioral responses to chronic stress were used to demonstrate how the differential epigenetic status of the glial cell-derived neurotrophic factor (Gdnf) gene in the ventral striatum modulates susceptibility and adaptation to chronic stress. Our results suggest that the histone modifications and DNA methylation of the Gdnf promoter have crucial roles in the control of behavioral responses to chronic stress. Our data provide insights into these mechanisms, suggesting that epigenetic modifications of Gdnf, along with genetic and environmental factors, contribute to behavioral responses to stress.


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Magnetization transfer MR imaging correlation with histopathology in intracranial tuberculomas.
MR Section, Department of Radiology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India.
Clinical Radiology (Impact Factor: 1.82). 09/2001; 56(8):656-63. DOI:10.1053/crad.2001.0752 Source: PubMed
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ABSTRACT: In vivo, ex vivo, and in vitro proton magnetic resonance spectroscopy was performed in 12 patients with intracranial tuberculomas with an aim of detecting the biochemical constituents of Mycobacterium tuberculosis in a granuloma. One dimensional (1D) single pulse and spin-echo sequences and 2D correlative spectroscopy were used for the ex vivo study to confirm the resonances seen on in vivo study. Spectroscopic studies of the perchloric acid and lipid extract of granuloma and M. tuberculosis were performed to look for similarity of resonance. In vivo study showed the presence of lipids at 0.9, 1.3, 2.0, 2.8 ppm, and phosphoserine at 3.7 ppm. All these resonances were confirmed on ex vivo study. In addition, distinct resonances of serine and phenolic lipids were seen on ex vivo and in vitro study of tuberculous granuloma, which have not been observed in other intracranial tumors. Lipid extract of granuloma and M. tuberculosis showed phenolic lipids at 7.1 and 7.4 ppm, a constituent of the cell wall of the bacteria in a tuberculoma. It appears that it may be possible to finger print the biochemicals of the cell wall of M. tuberculosis in a tuberculous granuloma and thus may help in detection and diagnosis of such lesions.Magnetic Resonance in Medicine 11/1996; 36(6):829 - 833. · 3.27 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Magnetization transfer imaging provides information about the structural integrity of macromolecular substances, such as myelin. Our objective was to use this imaging technique and contour plotting to characterize and to define the extent of white matter lesions in multiple sclerosis and traumatic brain injury. Magnetization transfer imaging was performed of 30 multiple sclerosis plaques and 10 traumatic white matter lesions. Magnetization transfer ratios (MTRs) were calculated for the lesions, for the normal- or abnormal-appearing surrounding white matter, and for remote normal-appearing white matter. MTR contour plots were constructed about these lesions. The contour plot appearance of MS plaques differed from that of traumatic white matter lesions. There was a gradual increase in MTR values at points at increasing distances from the center of the MS plaques; this was true for those lesions with and without surrounding T2 signal abnormality (halos). In contrast, there was an abrupt transition in MTR values between traumatic lesions and normal-appearing surrounding white matter. Additionally, the size of the MTR abnormality exceeded the size of the T2 signal abnormality for the MS plaques. MTR contour plots permit characterization and border definition of white matter lesions. Analysis of the contour plots suggests that MS is a centrifugal process with the lowest MTR within the center of the lesion. In contrast, traumatic white matter injuries are discrete lesions with abrupt transitions between the abnormal lesion and normal brain.American Journal of Neuroradiology 20(6):977-81. · 3.17 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Eight patients with intracranial tuberculomas were studied with CT and magnetic resonance (MR) imaging. Large, ring enhancing, solid lesions on CT showed low intensity on T2-weighted images and intermediate intensity on T1-weighted images. Small lesions, with ring enhancement on CT, showed central bright signal on T2-weighted images with a peripheral low intensity rim surrounded by high intensity edema. The MR imaging features of the tuberculomas were found to be distinct from those of abscesses, metastases, and gliomas.Journal of Computer Assisted Tomography 01/1988; 12(2):280-5. · 1.58 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.


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Age is just a number... filled with experiences, lessons and life.Writing about love is daunting. It really is.
To paint an accurate illustration of the way I felt when I first began tackling this topic, I ask you to envision me-a skinny, uncoordinated white girl measuring all of 5'3"-facing off with Shaquille O'Neal on the basketball court.
The entire scenario is silly and farcical, and that's exactly how I felt trying to form accurate conclusions about love, a force that is much like a giant on a basketball court. It's towering and intimidating and has the capacity to undo me. The challenge was intriguing, however, so I couldn't say no.
As I started brainstorming everything I'd learned about love over the short 30 years of my life, I quickly recognized that in pondering the mysteries of love, I was actually placing myself in the company of others who had sung and written and theorized about it. As I listened to their music, read their novels, and watched their films, the insights I gained helped shape my own. They bore witness to my experiences and gave voice to feelings I couldn't otherwise articulate.
More From YourTango: 10 Most Romantic Movie Moments
I share some of them with you here, intermingled with musings of my own.
1. Make a list, but don't let it rule you. It can be helpful to make a list of things you want in a romantic partner, and it can be equally helpful to throw that list away. Love asks that we remain open, and always ready for surprise.
2. Love doesn't require perfection. "There were so many presumptions that I'd allowed to be built into my own mind about what a wife should be. I thought she should be a show-stopping cook and a brilliant entertainer, a nonstop quick wit, a wild thing in bed, an effortless nurturer... but, if I can be honest, my grandmother was none of these things and she still enjoyed one of the most legendary lives and marriages that I've ever seen." -Kristine Gasbarre, How to Love an American Man
3. Be realistic. "In generations past, there was far less talk of 'compatibility' and finding the ideal soul-mate. Today we are looking for someone who accepts us as we are and fulfills our desires, and this creates an unrealistic set of expectations that frustrates both the searchers and the searched for... In other words, some people in our culture want too much out of a marriage partner." -Timothy Keller, The Meaning of Marriage
4. Let go. "The more I let people be who they are, instead of cramming them into what I need from them, the more surprised I am by their beauty and depth." -Shauna Niequist, Cold Tangerines
5. Men are not from Mars and Women are not from Venus. Contrary to popular belief, I don't buy the idea that men and women come from different planets. We both live here on Earth, and in spite of a few rudimentary differences, such as personal interests, or ways of approaching the world, I see more similarities between the sexes with every year that goes by.
More From YourTango: Never Heard From Your Date Again? 4 Things To Remember
6. Even the toughest of men have a soft spot somewhere on the inside. Take, for example, the words of Charles Bukowski, who wrote extensively about booze and whoremongering, and then one day wrote this:
"There's a bluebird in my heart that
wants to get out
but I'm too clever, I only let him out
at night sometimes
when everybody's asleep.
I say, I know that you're there,
so don't be
Then I put him back,
but he's singing a little
in there, I haven't quite let him
And we sleep together like
with our
secret pact
and it's nice enough to
make a man
weep, but I don't
weep, do
-Charles Bukowski, "The Bluebird."
7. Love requires courage.
8. Love is worth the pain. "But if in your fear you would seek only love's peace and love's pleasure, then it is better for you that you cover your nakedness and pass out of love's threshing floor, into the seasonless world where you shall laugh, but not all of your laughter, and weep, but not all of your tears." -Kahlil Gibran, The Prophet
9. Don't hold back. "I'd been afraid to really connect, fearing that I was dealing with someone who wasn't as great as he appeared, or that my beauty and its need to share itself could be rejected. In the end, isn't the result the same? Whether he was good or not, I held back, and now I don't have him." -Kristine Gasbarre, How to Love an American Man
More From YourTango: 5 Sexual Myths That Are Holding You Back
10. You have to love yourself before you'll have the capacity to love others. "Until I learned to love myself, I was never ever lovin' anybody else." -Madonna, "Secret"
11. Love deeply. "Above all, love each other deeply, because love covers over a multitude of sins." -1 Peter 4:8
12. Adjust your focus slightly. "General opinion is starting to make out that we live in a world of hatred and greed, but I don't see that. It seems to me that love is everywhere. Often, it's not particularly dignified or newsworthy, but it's always there-fathers and sons; mothers and daughters; husbands and wives; boyfriends, girlfriends, old friends." -Hugh Grant, Love Actually
13. Love is an investment. Choose wisely. "In these bodies we will live; in these bodies we will die. Where you invest your love, you invest your life." -Mumford & Sons, "Awake My Soul"
14. Follow your heart? Not exactly. My heart doesn't always know what it's talking about and shouldn't be the final authority.
15. Uncertainty happens. "After a while, I figured I was in love, but I kept my fingers crossed when I said it, in case I was wrong." -Jillian Lauren, Some Girls
16. Letting go is the hardest. Know when it's time to let go of someone you care about, and then be brave enough to do it.
More From YourTango: 3 Steps To Letting Go Of A Relationship That Is Not Working
17. Love isn't perfect. Sometimes, it's destructive. "We're going down, and you can see it too. We're going down, and you know that we're doomed. My dear, we're slow dancing in a burning room." -John Mayer, "Slow Dancing in a Burning Room"
18. You can't change him. "We may as well say good-bye because neither of us will ever be any different from what we are this minute." -Patricia Highsmith, The Price of Salt
19. Loneliness is a part of life. "When I get lonely these days I think, 'So BE lonely, Liz. Learn your way around loneliness. Make a map of it. Sit with it, for once in your life. Welcome to the human experience. But never again use another person's body or emotions as a scratching post for your own unfulfilled yearnings.'" -Elizabeth Gilbert, Eat, Pray, Love
20. Go slow and put others first.
21. Don't be an emotional prude. "I don't want to be a sexual prude. But I wonder if by pretending that sex is emotionally and morally no-strings-attached, a person becomes an emotional prude. An emotional prude uses sex to escape the commitment and vulnerability required in genuine relationship." - Tyler Blanski, Mud & Poetry
22. Love = Forgiveness. It's that simple. It's that difficult.
23. It's OK to be single. "We confer a lot of status and respect on people who are getting married… But there's nothing inherently more responsible or more admirable about being married. I'm thankful to be celebrating my 10th wedding anniversary this summer, but at the same time, I have a fair amount of friends whose marriages are ending-friends whose weddings we danced at, whose wedding cake we ate, whose rings we oohed and aahed over but that have been taken off fingers a long time ago." -Shauna Niequist, Bittersweet
24. It's worth it. My dad always told me that some of the hardest things in life would also be the most worthwhile. I'd say that describes love perfectly.
More From YourTango: 10 Dating Red Flags That Prove He's Not Worth A Second Date
25. Give love instead of seeking it out. "Love is an action. It is something I aspire to bring to the world, rather than something I feel that I am owed." -Jillian Lauren, Personal Interview
26. God is love; the biggest, best and most overwhelming kind. "God is an experience of supreme love." -Elizabeth Gilbert, Eat, Pray, Love
27. Love is everything. "If I have the gift of prophecy and can fathom all mysteries and all knowledge, and if I have a faith that can move mountains, but have not love, I am nothing." -1 Corinthians 13:2
28. Our sense of love is heightened in moments of sorrow.
29. In the final moments of your life, what will you be thinking of? "When the planes hit the Twin Towers, as far as I know, none of the phone calls from the people on board were messages of hate or revenge. They were all messages of love." -Hugh Grant, Love Actually
And finally, I leave you with this thought:
30. "Relationships are, alas, beautifully, not bound to my theories about relationships. They're better. They're real. They follow no formula." -Tyler Blanski, Mud & Poetry
Written by Christy Krumm for YourTango.com.
More From YourTango.com:


text:
Belize City Hotels
- Overview
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Fodor's Belize
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Black Orchid Resort
At a Glance
- Most upscale lodging near Baboon Sanctuary
- lovely riverside setting
- good food
- only 15 minutes from international airport
- Not directly in the Baboon Sanctuary
Check Rates from our Partners
Black Orchid Resort Review
This Belizean-owned resort in a pleasant and safe rural setting northwest of Belize City perches at the edge of the Belize River, where you can launch a canoe or kayak from the hotel's dock, or just laze about the riverside swimming pool and thatch palapa. The air-conditioned rooms (from around BZ$280, double in-season, plus tax) are large, with custom-made mahogany furnishings. The on-site restaurant serves good Belizean food (dinner around BZ$36).
- Address: 2 Dawson Ln., 12 mi (20 km) from Baboon Sanctuary Rural Belize District, Burrell Boom Village | Map It
- Phone: 225/9158; 866/437–1301 in U.S. and Canada
- Website: www.blackorchidresort.com
- Location: Belize City
Contact Information
- 16 rooms, 1 3-bedroom villa, 2 2-bedroom cabins.
- Rate includes no meals.
- Credit cards accepted.
Hotel Details
- 80 Degrees: Fodor's Helps You Find Your Best Beach Vacation Spots
- Fodor's Go List 2014: Where we are going in 2014
- World Cup Fever: Start planning your trip to Brazil!
- Fodor's 100 Hotel Awards: Check out the winners of 2013
- Weekend Getaways: Fodor's Recommends the Best Weekend Escapes in the US
- Great American Vacation: Find Your Next U.S. Trip with Fodor's
I've just returned from a fantastic 10 day adventure to Belize and wanted to share my trip report since reading so many of these before I went was so helpful.
i put off for too long shopping for a new Read more -
My fiancee and I are planning our honeymoon. Read more
For anyone who has been to both Chan Chich and Bosque del Cabo, how did you think the two compared? Read more
· News & Features
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Travelers to Belize will find a fairy-tale landscape of white-sand beaches, lush rain forests, and soaring ... Read more
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Do you dream about going snout-to-snout with a bear, or at least observing a bear from a safe and responsible... Read more
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Honeymoons are the chance to take the adventure of a lifetime.... Read more


text:
Who's Going
Event Details
The 18th Annual Rhode Island International Film Festival (RIIFF) proudly presents 2014 ScriptBiz UNBOUND, a day-long workshop that covers the nuts and bolts of being a screenwriter. This year's topic is "From Idea to Page to Screen" and is geared toward promoting yourself as a writer, finding producers, and networking your way to success. .
This year's annual ScriptBiz takes place Friday, August 8th in downtown Providence, RI., the workshop begins at 9:00 a.m. and runs to 5:00 p.m. The fee is $85. (Registration is at 9:00 a.m. to 9:30 a.m.)
When & Where
The Rhode Island Foundation
1 Union St #6
Friday, August 8, 2014 from 9:00 AM to 5:00 PM (EDT)
Add to my calendar
The FLICKERS: Rhode Island International Film Festival (RIIFF), has secured its place in the global community as the portal for the best in international independent cinema, earning the respect of domestic and foreign filmmakers, filmgoers and trend watchers. This confluence of art and commerce brought together world-class celebrities, award-winning filmmakers, new talent and audience members in record numbers last year. Ranked as one of the top 12 Festivals in the United States, RIIFF is also a qualifying festival for the Short Film Academy Award through its affiliation with the Academy of Motion Picture Arts & Sciences. There are 75 film festivals worldwide which share this distinction and RIIFF is the only festival in New England. The Festival takes place every August. For more information about the festival, please visit www.rifilmfest.org.


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Artist: Inland Knights Title: High Horse EP Label: Drop Music Genre: Deep House Quality: 320 kbps
1. Inland Knights – Same Talk (Original Mix) 2. Inland Knights – High Horse (Original Mix)
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The cute paisley print of this American Flyer luggage set lets you travel in chic style.
Product Features:
- Spinner wheels glide with ease.
- Locking, telescoping handles add convenience.
- Lined interiors keep clothes looking fresh.
- Uprights expand 2-in. for additional space.
- Organizational pockets and compartments hold essentials.
- Padded upright carry handles offer mobility.
- Overnight bag strap and handles help with travel.
What's Included:
- Large spinner upright: 28"H x 18"W x 13"D, 11.35 lbs
- Medium spinner upright: 24"H x 16"W x 11"D, 9.7 lbs
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- Wheeled duffel: 18"H x 12"W x 11"D, 4.5 lbs
- Overnight travel bag: 12"H x 18"W x 8.5"D, 2 lbs
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text:
All Boards
Got a question? Something on your mind? Talk to your community, directly.
Posts awaiting your approval
Ed Arter
March 08, 2014 at 08:52 AM
I looked at the plans and I would call this a "Piece-of- S---" job. All they are doing is …Read Morea partial shoulder widening(in my book) along with some precast panel patching. It's a $1.5 Mllion project--too small to make me gasp in Awe. You Know Bear --if you're going to widen a Ramp....then widen a ramp, don't patch and then Kiss -your-sister. To those who uses this ramp during rush hour, I'm sure that you will agree that a more substantial widening/realignment is required. Add a Full lane at each Ramp;Channelize; and Signalize( like SB55 at 126) and carry that widening from Essington to Lily Cache(Coordinate with the new footprint of the Rt 30 project). Now you got a project that is not a band aid but a solution to a growing cluster ---->explitive deleted.
Bad News Bears
March 08, 2014 at 10:36 AM
I agree Ed. That ramp needs a REAL widening, and 126 and 55 needs to be a REAL exit. I know…Read Morethere' s been talk of a new exit over by 4 Seasons park. It would be nice if these ramps were widened before that project starts. Or maybe we should all just be used to Plainfield being a cluster f#%$ every year
Tony Manjalagots
March 08, 2014 at 11:43 AM
There is no Adult Supervision in the State of Illness DOT. There is a large dart board where…Read Moredecisi ons are made though.
Vicky Polito
March 07, 2014 at 04:58 PM
The DSO is always a good bet for hearing lovely, live orchestral music in a very comfortable venue…Read Morew ith fine sight-lines and acoustics.
Tony Pedretti
March 05, 2014 at 09:06 PM
I am a Downers Grove home owner, resident and volunteer for the Yes for Independent Maps…Read Morecampaign.
I can answer any questions about our solution or how you can help.
Call me anytime at 312.834.3069 - or - email email@example.com
Tony Pedretti
March 05, 2014 at 09:08 PM
You can also reach out to us from our website. Click on The Campaign at the top of the page for…Read Moremor e information.
March 06, 2014 at 01:07 PM
My source is that there is no source! (That's all) Plus you say no standard exist, but yet…Read Moreyou want me to be held to a standard! You do a lot of double talking. You sound just like a politician! And then you add, worried about nothing of substance, why because you say it doesn't have substance. And by the way JeffK, I'm at the meetings when I can, so I can see and hear first hand. What about you? Rage is a strong word and is not me. Thanks for the miss detection.
March 06, 2014 at 02:11 PM
LOL, crazy alert! Your Right JeffK, you got me! lol! Have a great day!


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Shot grandma & grandpa's 70th wedding anniversary Save the Dates in Old Town San Diego, inspired by Disney & Pixar's "Up".
January 4, 2014
Let's give a moment to those mothers that can not have a child…
and to the husbands that stick by their wives regardless of wether they can have a child
This was the most realistic Disney movie ever.
yeah the part where the house flies off due to a bunch of balloons was very realistic
The wilderness must be explored! CAW-CAW! RAAAR!"
(Source: iamnevertheone)
I finally meet my childhood hero and he's trying to kill us. What a joke.
(Source: mjolnr)


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Aloha y'all, "2014 HERE WE COME....." Man, .....I always have this problem wondering where to start....well, here we go... As Da Kine's enters it's 17th year in existence, things have sure changed around me.....I have now evolved more towards a "Private Chef" kinda thing as I have elected to work on my own, (actually, this has been going on more than a few years), with help from my son on the weekends. You'll understand later in this note..... And if you run into Daniel, be kind to him as he has given up some of his life to help "his old man"... Because of this, my prices will not rise as I will let the "market" dictate what I charge my guests. I will be making my "living" from the labor portion of the orders.....you know...the time it takes to prepare and cook. BY the way, watch out for "beef prices"....they are going to go through the roof..... I will keep my cooking to the items that I've known for years. That way I can't screw something up....."it can happen".....maybe not to me.....but..... I still have tremendous pride in the food that I serve, I always have and that guests who return to order from me are a testament to that. To you all, my debt of "Thank You" cannot even be measured in a statement here. But know this, I will always be thankful for all of you......"really". And now the reason for this change....my wife, Belen..... So, it's been a very "crappy" year for her, resulting a quite a few back steps in her health.....She still has her wits about her on the good days, and maybe not so much on the bad ones. But through it all, she is still with me, and really,to me, that is the one thing that really matters. I again thank all who ask about her and wish her well, I do relay all of them to her when I get home that day. It means alot to her that people remember her. So, without getting anymore "sappy", it's time for the recap..... Da KIne's........still here........but getting older.. Da Kine's,....still here,......still kicking.....and tasting good as well.....give us a call when you need us, we'll be here....really. Or you can just talk story....you know me, I ALWAYS like to talk story.... Aztec Football and Basketball...."very impressive"....Chargers...."possibilities"......Rams....definately getting better, way better.....UH football......"oh my god"....and finally...the Lakers...."not as bad as everyone thought" Let's all have a great year since the "getting older" doesn't stop because you want it to....although you can hold it off for awhile..... Aloha y'all Uncle Nelson & Aunty Belen
Founders & Owners
Da Kine's Plate Lunches
Da Kine's Hawaiian Catering
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