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A Role for the Melatonin-Related Receptor GPR50 in Leptin Signaling, Adaptive Thermogenesis, and Torpor
A Role for the Melatonin-Related Receptor GPR50 in Leptin Signaling, Adaptive Thermogenesis, and Torpor
Current Biology, Volume 22, Issue 1,
Pages 70-77,
Publication Date 22 December 2011
Copyright © 2012 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.cub.2011.11.043
David A. Bechtold
Anissa Sidibe
Ben R.C. Saer
Jian Li
Laura E. Hand
Elena A. Ivanova
Veerle M. Darras
Julie Dam
Ralf Jockers
Simon M. Luckman
Andrew S.I. Loudon
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Inserm, U1016, Institut Cochin, Paris, France
CNRS UMR 8104, Paris, France
Université Paris Descartes, Sorbonne Paris Cite, 75006 Paris, France
Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
Corresponding author
► Gpr50−/− mice readily enter torpor upon fasting ► Torpor in KO mice is linked to reduced TRH expression and leptin response ► GPR50 modulates leptin effects on thermogenesis, but not on feeding ► In vitro, GPR50 significantly alters transcriptional responses to leptin signaling
The ability of mammals to maintain a constant body temperature has proven to be a profound evolutionary advantage, allowing members of this class to thrive in most environments on earth. Intriguingly, some mammals employ bouts of deep hypothermia (torpor) to cope with reduced food supply and harsh climates [1, 2,1, 2]. During torpor, physiological processes such as respiration, cardiac function, and metabolic rate are severely depressed, yet the neural mechanisms that regulate torpor remain unclear [3]. Hypothalamic responses to energy signals, such as leptin, influence the expression of torpor [4,5,6,7]. We show that the orphan receptor GPR50 plays an important role in adaptive thermogenesis and torpor. Unlike wild-type mice, Gpr50−/− mice readily enter torpor in response to fasting and 2-deoxyglucose administration. Decreased thermogenesis in Gpr50−/− mice is not due to a deficit in brown adipose tissue, the principal site of nonshivering thermogenesis in mice [8]. GPR50 is highly expressed in the hypothalamus of several species, including man [9, 10,9, 10]. In line with this, altered thermoregulation in Gpr50−/− mice is associated with attenuated responses to leptin and a suppression of thyrotropin-releasing hormone. Thus, our findings identify hypothalamic circuits involved in torpor and reveal GPR50 to be a novel component of adaptive thermogenesis in mammals.


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Not Peer Reviewed
Two Noble Kinsmen (Quarto, 1634)
The Two Noble Kinsmen.
Enter Daughter.
655Iailor. Your Friend and I have chanced to name
¶You here, upon the old busines: But no more of that.
¶Have an end of it: I'th meane time looke tenderly
¶To the two Prisoners. I can tell you they are princes.
¶Doe thinke they have patience to make any adversity
¶They have all the world in their Chamber.
¶Stand a greise above the reach of report.
670Mervaile how they would have lookd had they beene
¶A freedome out of Bondage, making misery their
¶Mirth, and affliction, a toy to jest at.
¶Captivity, then I of ruling Athens: they eate
680I'th deliverance, will breake from one of them.
¶Or at least a Sigher to be comforted.
Enter Palamon, and Arcite, above.

subset: commoncrawl


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28,756 plays
I just re-recorded my Frou Frou cover. Check it out! : ]
Sitting in Blake's studio while he works on demos for hours and hours. I'm doodling and drinking chai and I stumbled upon this in my archive and had to reblog again.
I will reblog this every time it comes up on my dashboard. Blake's voice is my fave.
havent heard this version in so long. gosh, its amazing.
Oct 12th / Tagged: music amazing my favorite best ever love / 3,324 notes †Omg can someone appreciate this cover with me? Haha.
going through all my tagged music.
Oct 12th / 9 notes †Sep 4th / Tagged: x factor kye sones save the world music / 3 notes †
Aug 22nd / 38,935 notes †i may be ugly but at least i dont wear heels to concerts
Aug 12th / 49,820 notes †my milkshakes bring all the boys to the yard and they're like
hey your friend is hot
Aug 12th / 137,773 notes †i'm really good at making plans and then not wanting to do them when the time comes


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Air King 9518 18-Inch Wall Mount Fan
- Perfect Fit for Gyms, Schools, and Churches
- Read More...
Keep your spaces cooled and comfortable with the Air King 9518 18 inch wall mount fan! This wall mount fan can effectively cool down your facility with no problem because it features:
Air King Quality
Air King industrial fans are durable and designed in North America. Not only are they known for quality, but also for value. The 9518's blade, guards, and mounts are made of powder coated steel.
Motor Build
The 9518's motor is permanently lubricated and permanently split capacitor along with a 9', 3-conductor type SJT power cord. The motor runs at 1/6 HP and 120 volts.
Uses and Applications
Use the 9518 in your gym, health club, auditoriums, schools, churches, and all kinds of industrial space to save space and energy. The 9518 is wall mounted so that you do not need to use floor space, and fans are more energy efficient than traditional AC units.
The 9518 can reach air deliveries of up to 3190 CFM and RPMs of 1500. It also can work at a maximum of 1.52 AMPs and 180 watts. On its highest setting, the 9518 emits 67 dBA.
- Model: 9518
- Product Type: Wall Mount Fan
- Product Dimensions: L: 24.00" x W: 16.50" x H: 28.00"
- Product Weight: 24.80 lbs.
- Product Color: Black
- Application: Ideal for gyms, auditoriums, schools, churches and industrial spaces that need powerful air circulation
- Type: Electric
- Warranty: 1-year limited manufacturer's warranty
- Max Air Flow: 5350 CFM
- Voltage: 120 volts
- Diameter: 18 inches
- Watts: 180 watts
- Oscillation: No
- Amps: 1.5 amps
- Frequency: 60 Hz
- Noise Level: 67 dB
- Certifications: ETL , OSHA
- Fan Style: Wall Mount
- Product Construction: Steel
- Adjustable Tilt: Yes
- Adjustable Height: No
- Number of Speeds: 3
- Motor Type: Permanently lubricated motor 1/6HP
- Remote Control: No
- Control Type: Rear mounted pull cord switch
- Timer: No
- Built-In Air Purification System: No
- Commercial/Industrial Use: Yes
- Easily pivots for desired angles and direction
- Easy access rear mounted switch
- Powder coated steel framing for durability
- Three separate speeds for your convenience and comfort
- Very cost effective way to cool yourselves and your space
- Wall mountable bracket is included in the kit
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Tottenham coach Tony Parks rates Carlo Cudicini the best goalkeeping backup in the country.
Cudicini could be handed a start in their FA Cup tie with Bolton Wanderers.
"I don't see anyone who puts so much into it and doesn't become affected by not playing for long periods.
"Carlo can go for weeks and weeks without playing a game and when you need him, he steps in and plays well.
"I don't think that has been underlined more than this season.
"He's so composed and he's just such a nice and easy guy to work with. In fact, all the goalkeepers are easy to work with because they all know how to do the job properly.""I think we're lucky in that I don't think there is a better person to have as a back-up goalkeeper than Carlo Cudicini anywhere in world football, I'd go as far to say that," said goalkeeping coach Parks to the Spurs website.


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Cooking is enough of a headache on holidays, so let us take care of planning your menu! We've rounded up the lightest, most delicious holiday recipes your most health conscious and diet conscious of guests will love. Let's dig in!
Healthy Holiday Menu: Healthy Christmas Recipes
Whether your big …
Read More


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Tag Archives: Career Advancement
9 Savvy Ways to Conquer a Workday of Chaos
Sail through hell days at the office with ease
Sometimes, the days can get more than hectic in the office. Here's how to sail…
By Janell Hazelwood
9 Ways To Tactfully Handle Your Boss Stealing Your Idea
The dos and dont's of confronting your boss.
Have you ever had an idea that you thought would be great for your business?…
By Sasha King
6 Reasons You Should Avoid White Lies At Work
The ramifications of a white lie are a lot more far reaching than at first anticipated
Almost everyone has done it. Lied to someone to spare their feelings, to get out…
By Sasha King
New Grads: 10 Career Boss Moves to Make Right Now
This checklist will get you through the first vital days post-graduation
Here's a checklist of things you should get accomplished within the first 200 days post…
By Janell Hazelwood
Sheila Abdus-Salaam Set to Become First Black Woman Appointed to New York's Top Court
Judge selected by the governor could make history
Judge Sheila Abdus-Salaam has been nomination by Gov. Andrew Cuomo to serve on the U.S.…
By Sasha King
Success Secrets Exposed: 5 Steps to Upgrading the Game after Graduation
Dennis Kimbro, Ph.D. shares a strategy for job market advancement
Dennis Kimbro, Ph.D., best-selling author and speaker, shares a strategy that can arm grads with…
By Antoine Moss
Homie, Coworker, Friend: Pros and Cons of Working with Loved Ones
It may be tricky to balance relationships, so consider all risks
It may seem like the job of your dreams working with people you already mesh…
By Sasha King
Started from the Bottom: Lessons at the Entry-Level
Tips that will help you see the bright side of the experience
You may be at the bottom for now, and maybe you feel disappointed by that.…
By Sasha King
5 Savvy Ways to Say No … Without Uttering the Word
Whether you're just passive aggressive or dread the decline, use this strategy
Whether you're terrible at being direct or you can't afford to lose your job, here…
By Janell Hazelwood
Cool Jobs: SaGe Services CEO Helps Facilitate Global Tech Innovations
Tapua Tunduwani draws from global experience to meet a vital need
CEO of Sage Services, Tapua Tunduwani turns passion into profit by providing flex space for…


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Before I met Amanda Mills I had memories of William Wallace's speech in Braveheart about being 7 feet tall and shooting bolts of lightning out his ass. Her reputation seemed pretty legendary.
We became fast friends with similar interests concerning outdoor activities, Taco Bell, defacing renaissance art and our love for buddy cop movies.
With the media's focus as of late on our impending doom, it's become increasingly difficult to view the horror movie genre and even Fox news reports as being tongue-in-cheek.


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| |
RATINGS: 256 WEIGHTED AVG: 3.74 SEASONAL: Winter EST. CALORIES: 240 ABV: 8%
COMMERCIAL DESCRIPTION This is the kind of beer that gives the word "stout" a reputation. Extra generous quantities of barley malt, followed by vigorous fermentation leaves this "imperial" heavy weight with 8% alcohol A.B.V. and a body as full as chocolate bread pudding. A complimentary and complex array of bitter notes comes form potent American hops, earthy British hops, black-roasted malts and, of course, coffee. Santa Fe Brewing Company uses only top-quality ingredients like organically grown East Timor coffee beans blended with New Guinea coffee beans, locally roasted by Ohoris Coffee House. Its heavenly flavor and aroma cant be beat or imitated.
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7 conference presentations on Identity. See Identity conferences.
Your current filters are…
from Identity Tech Overview: Less Pain, More Gain at Google I/O 2013, 15th-17th May 2013
Added 9 months ago
from The web beyond "usernames & passwords" at Kiwi PyCon 2012, 1st-2nd September 2012
Added 1 year ago
from The web beyond "usernames & passwords" at PyCon Australia 2012, 18th-19th August 2012
from OAuth 2.0 for Identity and Data Access at Google I/O 2012, 27th-29th June 2012
from Navigating The Gender Landscape at Farmhouse Conf 2, 5th May 2012
from Data Identity Narrative at Ignite Sebastopol 7, 18th April 2012
from Identity and Data Access: OpenID and OAuth at Google I/O 2011, 10th-11th May 2011
Added 2 years ago
Browse and track events by topic


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Beach Area Website Home Page Meeting Schedules Activities, Events and Events Calendar Other Announcements and Information, Clean Date Calendar Area Service Committee Information and Area Archives Area Sub-committees Literature Sales SDICRNA Regional Website Home Page NA World Services Website Home Page Links to Other NA Websites |
ACTIVITIES and EVENTS
The Activities and Events listed here are not limited to only ones in the Beach Area.
If your group would like to post an announcement or a flyer, please contact SCOTT W. at 858-354-6670 or BASC WEBSITE SUB-COMMITTEE To view PDF files, you'll need Adobe® Acrobat™ Reader. Click here to download Click on Address for Map and Directions (enter your address on Line B and reverse directions) For information on activities in other areas of the San Diego/Imperial Count Region visit the REGIONAL WEBSITE Return to Top of Page REGIONAL ACTIVITIES AND EVENTS NARCOTICS ANONYMOUS WORLD SERVICES PRESENTS |
Please direct questions or comments regarding this website to: BASC WEBSITE SUB-COMMITTEE © Copyright 2010 SDICRNA |


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Project by Troy | posted 1528 days ago | 1325 views | 3 times favorited | 11 comments |
Previous project. Maple box with bloodwood splines and walnut top
-- Troy Bouffard || Master Sergeant, US Army (Retired) || http://www.birchhillwoodcrafts.com
Pin It |
11 comments so far
#1 posted 1528 days ago |
That's a nice one. BZ -- Dudley Young USN Retired. Sebastian, Fl. |
#2 posted 1528 days ago |
Very nice, Troy! I've made a few of that design and they make a real nice box. Love the combination of maple and walnut – the two woods just seem as though they are supposed to go together. Good job! Jim -- A veteran is someone who, at one point in his/her life, wrote a blank check made payable to "The United States of America," for an amount of "up to and including his/her life". |
#3 posted 1528 days ago |
Well done. Ditto on the wood combo. |
#4 posted 1528 days ago |
Making some nice stuff Troy -- Happiness is being covered in sawdust |
#5 posted 1528 days ago |
Very nice looking box with sharp & clean miter splines. -- masrol, kuala lumpur, MY. |
#6 posted 1528 days ago |
Really nice, clean design and construction! -- Charlie M. "Woodworking - patience = firewood" |
#7 posted 1528 days ago |
Looks good. I like the the style. -- Life is about choices. You can spend a lot of money on furniture and have really nice furniture; Or you can spend a lot on tools and have even more expensive, crappy furniture. I made my choice. |
#8 posted 1527 days ago |
Fantastic box. Agree with all the above. Great shape, great woods, great build. Keep it up. Scrappy -- Scrap Wood's the best...the projects are smaller, and so is the mess! |
#9 posted 1523 days ago |
That box looks awesome -- Monty Q, Columbia, South Carolina. |
#10 posted 1522 days ago |
Very nice work. Is the lid hinged or is it a lift off style? |
#11 posted 1511 days ago |
nice work love the frame and panel top. -- Ike, Big Daddies Woodshop, http://firstname.lastname@example.com |
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How do we do this? Our handsome sofas and armchairs can withstand the outdoor elements for many years, yet look good enough to grace your indoor living space. We feature solidly constructed armchairs, corner chairs, loungers, and loveseats, all boasting weather resistant cushions. Our selection of Mission and Adirondack furniture, gliding benches, rocking chairs, even stackable pool chairs, can be found in slatted and sling styles which come framed in poly-wood, treated hardwoods, and durable plastics.
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SUNDERLAND on SATURDAY: Easy money is no long-term solution
It is an irony that one of the longest-running debates in this country is about short-termism. But short-termism has become ingrained in British business culture, as George Cox, the former Institute of Directors boss who this week published the latest report on the subject, points out.
Large companies have no qualms about selling themselves to foreign predators, or embarking on knee-jerk rounds of redundancies the minute revenues begin to quaver.
Entrepreneurs often suffer from 'Old Rectory syndrome', dreaming of early retirement to a country village, rather than founding a family business dynasty.
Key to recovery: George Osborne's 2011 Autumn Statement flourished a plan to harvest £20billion for infrastructure, but this has hit the buffers
This mindset means the UK fails miserably at supporting industries where we still excel, such as aerospace.
For every £1 invested by the Government in research in the sector, the French invest £8 and the Germans £12.50.
We still have world class universities capable of producing amazing innovations, but do not exploit them. Graphene, the new wonder material, was developed at Manchester University, yet UK businesses have filed only 54 related patents, compared with more than 1,700 from the US and more than 2,200 from China.
The short-termist mentality in politics compounds the problem.
One glaring example is inadequate airport capacity in the South East of England, an issue first raised in 1955, according to Cox.
Ditto energy policy.
Hopes of a nuclear renaissance are now hanging by a gossamer thread as the government cannot agree a price structure with EDF, the main player. If the charade continues, we are at risk of the lights going off.
There is a broad consensus that long term infrastructure investment is key to recovery.
George Osborne in his Autumn Statement back in 2011 flourished a plan to harvest £20billion for infrastructure from pension funds and insurers, but this has hit the buffers.
The chief executive of Legal & General this week complained he has billions currently invested in overseas bonds that he wants to invest in UK projects but cannot, due to the 'glacial' pace at which they proceed.
In lieu of a compelling long-term strategy for growth, the Chancellor is relying far too heavily on the stimulus of easy money from the Bank of England – a route he criticised whilst still in opposition.
In his Budget, Osborne will almost certainly pave the way for new Bank of England governor to escalate the policy into even more extreme territory, such as negative interest rates. But the solution to the UK's economic woes is not to be found in ever more experimental monetary policy, which has the perverse effect of helping borrowers and enriching millionaires while hurting the elderly, the thrifty, and the badly off.
QE was only ever meant to be a short-term emergency measure; it is not a substitute for real long term solutions.
Bank for business
The idea for 17 big City fund managers to buy 315 branches from RBS is an excellent one – and it would be even better if they could take on the 632 Project Verde branches from Lloyds while they were at it.
The Verde business is supposed to be passing to the Co-op, but it must be said the deal is taking a very long time. A dedicated small business and retail bank of real scale would make a huge difference to the plight of credit-starved small firms, and by extension to the whole economy.
Disgracefully, the Big Four banks are still not lending nearly enough to small business. Tiny building societies such as Leek United and Newbury are doing more net lending than RBS or Lloyds, and Sir Mervyn King even advised one applicant to try a Swedish bank.
The banks claim their hands are tied as regulators require them to hold more capital as a safety buffer. In reality, RBS, Barclays and HSBC could choose to lend more to small firms here, but have extensive non-UK operations and investment banking activities.
There would be major practical difficulties in establishing the RBS and Lloyds branches as a new small business bank.
Problems with unravelling branches from the parent network and making the IT work have already stymied attempts by the two state-backed lenders to divest.
Still, it is an attractive idea, not least because it would show the City backing Britain's long term interests.
Ruth Sunderland is Associate City Editor of the Daily Mail
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Join us online on March 11 to help launch a new network for action and change.
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Last modified: November 29, 2010, 1:59 PM
Easter Seals Greater Washington-Baltimore Region provides exceptional services to ensure that all people with disabilities or special needs and their families have equal opportunities to live, learn, work, and play in their communities.
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Natural products is the direction i want to go as i feel it's important to me what i put on my skin and hair. And so i came across Raw Gaia and i'm very happy with the products that i've purchased so far. They always dispatch quickly as well. I will be ordering again in the future. Thank you Raw Gaia.
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Might the Fed profit from the financial crisis?
Its intervention at Bear Stearns shows a change in attitude toward investment banks.
Most economists would agree that the world's financial markets are facing an extraordinary crisis with the credit freeze, the failure of some prominent financial institutions, and deep losses at other firms.
Skip to next paragraphSubscribe Today to the Monitor
It's a "financial panic," says John Coffee, a finance professor at Columbia University in New York. He sees a "real chance" that losses could exceed those from the savings and loan institution disaster in the United States from 1986 to 1995. The failure of 1,043 thrifts cost the federal government some $153 billion.
The trouble in the American housing market has certainly hit the financial markets. But so far, economists are mostly predicting a run-of-the-mill, mild and short recession in the US after some six years of economic expansion.
"We have yet to see any really significant effect outside of the housing industry, broadly construed," says Ben Friedman, a finance professor at Harvard University in Cambridge, Mass. Spreading home foreclosures, declining home prices, and other housing troubles could spread to the economy as a whole, he notes. But up to now, the financial crisis appears to be largely "contained in the financial market."
The recent unusual remedial actions by central banks and governments are aimed at preventing the panic from spreading to other financial institutions and the economy in general.
Of course, the world's financial community is worried. Since last fall, a committee of the Institute of International Finance (IIF) in Washington has been preparing a report to address the crisis and avoid future panics. The financial CEOs in the committee plan to present the report before the April 11 meeting of central bankers and finance ministers of the Group of Seven major industrial nations in Washington.
The IIF represents the world's largest 375 financial institutions – commercial banks, investment banks, insurance companies, and others – in more than 60 countries. Its report will make suggestions as to more regulation of the financial industry, including sellers of home mortgages. It will deal with weaknesses in the management of financial risk, including that of complex structured financial products involved in the current crisis. It will address the valuation of such products and the adequacy of secondary markets where they are bought and sold after their primary sale to investors. It will touch on the adequacy of the documentation and information provided on these products. It will tackle the failure of rating agencies, such as Standard & Poor's, to provide accurate evaluations of the risk of failure of these financial products.


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We all realize that MBB is in a rebuilding process. But one of the frustrating aspects is that we have not even gotten an upset victory here or there to cheer about.
0-8 on the road in conference. We ended with three second division teams (MU, CU, TT) and couldn't pull out a road victory as a sign the team was improving.
No upsets of ranked teams at home. Not even a win over a first division team.
Once some players started looking better (DG and Brackins) at the end of the year, Wes starts to struggle and Rashon's injuries and bad luck still keep us from looking like a complete team.
Just throw us one bone. Beat A&M in KC and give us one day to smile! Just one.


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7 Fans
May. 20th, 1946
Born in
El Centro, California, USA
5' 8 1/2"
Cher's Main TV Roles
Main Movie Roles2003 - Stuck on You1999 - Detroit Rock City 1999 - Tea with Mussolini 1994 - Prêt-à-porter 1992 - The Player 1990 - Mermaids 1987 - Suspect 1987 - The Witches of Eastwick 1987 - Moonstruck 1985 - Mask 1983 - Silkwood 1967 - Mondo Hollywood |
The beat goes on ... and on ... and as strong as ever for this superstar entertainer who has well surpassed the four-decade mark while improbably transforming herself from an artificial, �ber-glossy "flashionplate" singer into a serious, Oscar-worthy, dramatic actress ... and back again! With more ups and downs than the 2008 Dow Jones Industrial Average, Cher managed to rise like a phoenix from the ashes each time she was down and counted out, somehow re-inventing herself with every changing decade and finding herself on top all over again. As a singer Cher is the only performer to have earned "top 10" hit singles in four consecutive decades; as an actress, she and Barbra Streisand are the only two Best Actress Oscar winners to have a #1 hit song on the Billboard charts. At age 62, Cher has yet to decide to get completely off her fabulous rollercoaster ride, although she has threatened to on occasion.
The daughter of an Armenian truck driver, John Sarkisian, and an Arkansas-born mother, Georgia Holt (the former Jackie Jean Crouch), Cher was born in El Centro, California, on May 20, 1946. She and sister Georganne LaPiere are part Cherokee and French. The father deserted the family when both were young and they were raised by their mother who later married Gilbert LaPiere, a banker. Cher's mother, who had aspirations of being an actress and model herself, paid for Cher's acting classes despite her daughter having undiagnosed dyslexia, which acutely affected her studies. Frustrated, Cher quit Fresno High School at the age of 16 in search of her dream.
Meeting the quite older (by 11 years) Sonny Bono in 1962 changed the 16-year-old's life forever. Bono was working for record producer Phil Spector at Gold Star Studios in Hollywood at the time and managed to persuade Spector to hire Cher as a session singer. As such, she went on to record backup on such Spector classics as "You've Lost That Lovin' Feeling" and "Be My Baby". The couple's relationship eventually shifted from soulmates to lovers and she and Sonny married on October 27, 1964.
At first Cher sang solo with Sonny behind the scenes writing, arranging and producing her songs. The records went nowhere. Sonny then decided they needed to perform as a team so they put out two songs in 1964 under the recording names of Caesar and Cleo ("The Letter" and "Baby Don't Go"). Again, no success. The changing of their names, however, seemed to make a difference and in 1965, they officially took on the music world as Sonny & Cher and earned instant rewards.
The now 19-year-old Cher and 30-year-old Sonny became huge hits following the release of their first album, "Look at Us" (summer, 1965), which contained the hit single "I Got You Babe". With the song catapulting to #1, they decided to re-release their earlier single "Baby Don't Go", and it also raced up the charts to #8. An assembly line of mild hits dotted the airwaves over the next year or two, culminating in the huge smash hit "The Beat Goes On" (#6, 1967). Between 1965 and 1972 Sonny & Cher charted a total of six "Top 10" hits.
The kooky couple became icons of the late '60s "flower power" scene, wearing garish garb and outlandish hairdos and makeup. However, they found a way to make it trendy and were embraced around the world. TV musical variety and teen pop showcases relished their contrasting styles -- the short, excitable, mustachioed, nasal-toned simp and the taller, exotic, unflappable fashionista. They found a successful formula with their repartee, which became a central factor in their live concert shows, even more than their singing. With all this going on, Sonny still endeavored to promote Cher as a solo success. Other than such hits with "All I Really Want to Do" (#16) and "Bang, Bang" (#2), she struggled to find a separate identity. Sonny even arranged film projects for her but Good Times (1967), an offbeat fantasy starring the couple and directed by future powerhouse William Friedkin (I), and Cher's serious solo effort Chastity (1969) both flickered out and died a quick death.
By the end of the 1960s, Sonny & Cher's career had stumbled as they witnessed the American pop culture experience a drastic evolutionary change. The couple maintained their stage act and all the while Sonny continued to polish it up in a shrewd gamble for TV acceptance. While Sonny on stage played the ineffectual object of Cher's stinging barbs on stage, he was actually the highly motivated mastermind off stage and, amazingly enough, his foresight and chutzpah really paid off. Although the couple had lost favor with the new 70s generation, Sonny encouraged TV talent scouts to catch their live act.
The network powers-that-be saw potential in the duo as they made a number of guest TV appearances in specials and on variety and talk shows and in what was essentially "auditioning" for their own TV vehicle. "The Sonny and Cher Comedy Hour" (1971) was given the green light as a summer replacement series and was an instant sensation when it earned its own time spot that fall season. The show received numerous Emmy Award nominations during its run and the couple became stars all over again. Their lively, off-the-wall comedy sketch routines, her outr� Bob Mackie fashions and their harmless, edgy banter were the highlights of the hour-long program. Audiences took strongly to the couple who appeared to have a deep-down sturdy relationship. Their daughter Chastity Bono occasionally added to the couple's loving glow on the show. Cher's TV success also generated renewed interest in her as a solo recording artist and she came up with three #1 hits during this time ("Gypsys, Tramps & Thieves," "Half-Breed" and "Dark Lady").
Behind the scenes, though, it was a different story. A now-confident Cher yearned to be free of husband Sonny's Svengali-like control over her life and career. The marriage split at the seams in 1974 and they publicly announced their separation. The show, which had earned Cher a Golden Globe Award, took a fast tumble as the separation and divorce grew more acrimonious. Eventually they both tried to launch their own solo variety shows, but both failed to even come close to their success as a duo. Audiences weren't interested in Cher without Sonny, and vice versa.
In June of 1975, only three days after the couple's divorce, Cher married rock musician Gregg Allman of The Allman Brothers Band. That marriage imploded rather quickly amid reports of out-of-control drug use on his part. They were divorced by 1977 with only one bright outcome -- son Elijah Allman.
In 1976 Sonny and Cher attempted to "make up" again, this time to the tune of a second "The Sonny and Cher Show" (1976). Audiences, however, did not accept the "friendly" divorced couple after so much tabloid nastiness. After the initial curiosity factor wore off, the show was cancelled amid poor ratings. Moreover, the musical variety show format was on its way out as well. Once again, another decade was looking to end badly for Cher.
Cher found a mild success with the "top 10" disco hit "Take Me Home" in 1979, but not much else. Not one to be counted out, however, the ever resourceful singer decided to lay back and focus on acting instead. At age 36, Cher made her Broadway debut in 1992 in what was essentially her first live acting role with "Come Back to the Five and Dime, Jimmy Dean, Jimmy Dean". Centering around a reunion of girlfriends from an old James Dean (I) fan club, her performance was critically lauded. This earned her the right to transfer her stage triumph to film alongside Karen Black (I) and Sandy Dennis (I). Cher earned critical raves for Come Back to the Five and Dime, Jimmy Dean, Jimmy Dean (1982), her first film role since 1969.
With film #2 came a Best Supporting Actress Oscar nomination and a Golden Globe win for her portrayal of a lesbian toiling in a nuclear parts factory in Silkwood (1983), starring Meryl Streep and Kurt Russell (I). This in turn was followed by her star turn in Mask (1985) as the blunt, footloose mother of a son afflicted with a rare disease (played beautifully by Eric Stoltz). Once again Cher received high praise and copped a win from the Cannes Film Festival for her poignant performance.
Fully accepted by this time as an actress of high-caliber, she integrated well into the Hollywood community. Proving that she could hold up a film outright, she was handed three vehicles in 1987 to star in, highlighted by her sparkling, Oscar-winning turn in the romantic comedy Moonstruck (1987). Along with all this newfound Hollywood celebrity came interest in her as a singer and recording artist again. "If I Could Turn Back Time (#3) and the Peter Cetera duet "After All" (#6) placed her back on the Billboard charts.
During the 1990s Cher continued to veer back and forth among films, TV specials and expensively mounted concerts. In January of 1998, tragedy struck when Cher's ex-husband Sonny Bono, who had forsaken an entertainment career for California politics and became a popular Republican congressman in the process, was killed in a freak skiing accident. That same year the duo received a star on the Hollywood Walk of Fame for their contribution to television. In the meantime an astounding career adrenalin rush came in the form of a monstrous, disco-flavored hit single ("Believe"). The song became a #1 hit and the same-titled album the biggest hit of her career. "Believe" reached #1 in 23 different countries.
Having little to prove anymore to anyone, Cher decided to embark on a "Farewell Tour" in the early part of the millennium and, after much stretching, her show finally closed in 2005 in Los Angeles. It didn't take long, however, for Cher to return from this self-imposed exile. In 2008 she finalized a deal with Las Vegas' Caesars Palace for the next three years to play the Colosseum. Never say never.
In other facets of her life, Cher has been involved with many humanitarian groups and charity efforts over the years, particularly her work as National Chairperson and Honorary Spokesperson of the Children's Craniofacial Association, which was inspired by her work in Mask (1985).
- Ranked #26 on VH1's 100 Sexiest Artists.
- Is a big 'Katharine Hepburn' (qv) fan.
- Spoke the eulogy at ex-husband 'Sonny Bono' (qv)'s funeral.
- Her parents married and divorced 3 times.
- She and 'Barbra Streisand' (qv) are the only two female performers in the U.S. to have had a #1 hit and won an Oscar.
- A 2002 Rolling Stone article estimated her wealth at over $600 million. Since then she has embarked on a hugely successful farewell tour that is still going and released a greatest hits CD that has spent weeks in the the Billboard Top 10.
- Her half-sister, 'Georganne LaPiere' (qv), was the first wife of 'Michael Madsen (I)' (qv).
- Holds the record for the the longest gap between #1 hits ("Dark Lady" 1974, "Believe" 1999).


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Home » News » Crime
Search continues for missing Charlestown woman
Robarge, 42, of 124 Happy Acres Road, was last seen in the late morning hours on Thursday, and worried family and friends reported her missing around 4:30 p.m. that day, according to Susan Morrell, senior assistant attorney general.
"I can't comment on where any of the evidence is leading us other than it's given us cause for concern for her safety," she said.
White said Kelly Robarge has two adult daughters and a young grandson.
White said the first inkling of trouble came Thursday evening, when a neighbor called to check on the well-being of her husband, who has a medical condition. The neighbor told them to look outside, where they saw five state police cruisers and a local police cruiser parked near the end of their driveway.
Still, she said, "We just thought that they must have found a crime scene and maybe some kind of violence because it sounded that way."
"They seemed like pretty nice people," his wife, Cathy Hewey, said.
Asked whether there's a risk to the public, given the suspicious disappearance of a local woman, Morrell said it's too soon to definitively answer that question.
Authorities are asking anyone with information regarding the disappearance or whereabouts of Robarge to contact state police at 271-3636.
swickham@ unonleader.com
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- Visit
Today's Hours
9:00am to 5:00pm
- Calendar
- The Estate
- George Washington
- Education
- Library
- About
- Search
9:00am to 5:00pm
Cyclists can reach Mount Vernon from Washington, D.C. via the Mount Vernon trail. Nearly 18 miles long, the paved Trail follows the Potomac River's Virginia shoreline from Theodore Roosevelt Island (near Rosslyn, Virginia) to Mount Vernon. Bike racks are located at the end of the bike trail.
Bicycle enthusiasts without a bike can also visit Mount Vernon by renting a bike from Bike and Roll in Old Town Alexandria and enjoying the final scenic ten miles of the Mount Vernon trail through Dykes Marsh and Belle View Park. The canopy coverage and banks of the Potomac provide seclusion and a beautiful transition back in time to an early America, making the ride a wonderful way to approach the timeless feel of Mount Vernon.
Prices for bike rental from Bike and Roll, including Estate admission:
Adults $48
Children (6-12) $31
Bike and Roll Tours are offered April - October. Call Bike and Roll at 703-548-7655 for reservations and more information or book online at www.bikethesites.com.
You can also rent a bike from Bike and Roll in Old Town Alexandria, ride to Mount Vernon, and return to Alexandria on Potomac Riverboat's Miss Christin for a narrated cruise back to Old Town. Recommended departure from Alexandria is 11 a.m., since Miss Christin departs Mount Vernon at 4 p.m. The boat arrives back in Alexandria at 5:30 p.m. Boat rides are seasonal and space is limited, so advance registrations are required.
Prices for bike rental from Bike and Roll, bike pick-up at Mount Vernon, and return boat ticket, including Estate admission:
Adults $63
Children (6-11) $40
Children (2-5) $20
Bike and Roll Tours are offered March - November. Call Bike and Roll at 703-548-7655 for reservations and more information or book online at www.bikethesites.com.
This web site was generously supported by the late Robert H. Smith and his family.
©2014 Mount Vernon Ladies' Association. All Rights Reserved.


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Thomas M. Davidson, 25, of Poseyville, entered a not guilty plea during an arraignment Monday on multiple charges related to the Aug. 16 shooting death of Sandra K. Burkhardt, 58, of rural Poseyville.
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83% of the CEO
Charles D. Davidson
I worked at Noble Energy as a contractor for less than a year
Pros – The employees were very nice. The management teams that I worked with were also very nice. They are a very strong Oracle Shop and try to stay up to date with the latest technology.
Cons – n/a. I will not say anything bad about the place as I would go back there if given an opportunity.
Advice to Senior Management – Allow a few work from home days. The employees are all great and should be able to telecommute whenever they have special situations going on. It takes some employees over a hour and a half to get into the office.
Yes, I would recommend this company to a friend – I'm optimistic about the outlook for this company
I have been working at Noble Energy full-time for more than a year
Pros – Ethical company and management which demonstrates respect for its people and contractors, and for continued solid hard work, diligence and productivity.
Cons – Too many employees and supervisors goofing off most of the day and creating problems in business unit morale and workflow. Too much reporting in one area but not enough in other sections. Some supervisors don't know what they need to know to help with questions.
Advice to Senior Management – Managers need to crack down on employees and supervisors who are not putting in a full days' work - demoralizing and distracting to employees who are working, especially when the ones not working are in a supervisory position. Too much talking, personal internet usage, griping and egos wanting to be promoted without doing what they were hired to do now. Better screening or interviewing of candidates' experience and references is needed to be sure that new hires actually know what they say they know. Too many emplohyees leaving the office for golf outings or rig tours and leaving work undone.
Yes, I would recommend this company to a friend – I'm optimistic about the outlook for this company
1 person found this helpful
I have been working at Noble Energy full-time for less than a year
Pros – Good pay/benefits. Friendly environment. Passionate individuals. Can move around in the company. Great people. Safe practices. Interesting business to get involved in. All the people here seem to really care about each other and their jobs.
Cons – Traditional when it comes to stuff like working at home or setting your own hours. I honestly can't think of any other cons. My experience at this company this far has been amazing.
Yes, I would recommend this company to a friend – I'm optimistic about the outlook for this company
1 person found this helpful
I have been working at Noble Energy as a contractor for less than a year
Pros – The culture and sense of worth are a few things I picked up right away. Everyone is eager to share knowledge and work together for the company!
Cons – I have not seen any downsides to working at Noble.
Yes, I would recommend this company to a friend – I'm optimistic about the outlook for this company
Noble Energy, Inc. is a leading independent energy company with a track record of success, a sound strategy for the future and a variety of unique and challenging careers. With a global scope and broad-based operations… — Full Overview
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Wormrot arrested in Malaysia
Singaporean grinders Wormrot were arrested in Malaysia in the early hours of New Year's Day by religious authorities.
According to the band's Tumblr, Wormrot were playing a New Year's Eve show in Kuala Lumpur. While at their hotel, the Jabatan Agama Islam Selangor (Selangor Islamic Religious Department) came into their room. Azean, the band's manager, says:
"After several questions and telling us that it is wrong for unmarried Muslim men and women to be in one room, they took our passports and we were taken to the police station to give our statements and call someone to bail us."
"5 of us were taken into custody. Arif [vocals], Rasyid [guitars], Fit [drums], his girlfriend who is Arif's little sister and myself. Rasyid's girlfriend was not taken into custody coz she's not Muslim and Fiaz [Asilent bassist, with them at the time] was from another room. When we got out of the hotel to be escorted into the police lorry which already has some couples who were caught earlier than us, around 30 – 40 more people from JAIS, passerby and maybe some people from the media took pictures of us as though they had busted the most biggest crime for the night. We were taken to the Taman Muda Police Station and had to sit on the floor to wait for the organizer, Emi, to come and bail us out. Emi arrived at 4am and he had talked to one of the JAIS staff. At around 4.15am, we were taken to another police station as there was no high ranking officer to do up the reports. Again everyone had to be escorted into the lorry to be driven to Pandan Indah Police Station. However, when we arrived there, we were still held in the lorry as the high ranking staff from JAIS have not arrived. At around 5am, when they finally arrived, we thought that we will be taken into the police station for our statements. But… in the end… we were let off with just a warning. We were nearly fined $3000 MYR ($950 USD) per person if Emi did not call his lawyer up and we being Singaporeans. Plus we weren't doing any sexual intercourse when they entered our room.
"By the time Emi sent us back to our hotel, it was already 5.30am. We were beyond exhausted as we had been awake since 5am the day before, performing and then the hotel drama."
Azean ends what must have been a frightening account on a positive note:
"Please do not think badly of the religion. Every religion is peaceful. Like I've said before, in every religion, there's always some people who are extremists. Don't condemn the religion just because of these jokers.
"We would like to thank Emi, Tiong, Dyn and all our friends who had given us the best hospitality anyone could ever asked for. And all the grinders who came down for the show to support all the bands. This is the best New Year celebration for us!"
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See headliners like Nick Swardson, Chelsea Handler, Chris Hardwick and more at the 2014 South Beach Comedy Festival.
»Buy nowYou might know him from "21 Jump Street" or have heard his characters on Kanye West's albums, but if you haven't seen DeRay Davis' stand-up, you're missing out. He'll be at the Charlotte Comedy Zone March 13-15, so get your tickets now.
»Buy Tickets


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Schedule for Monday, November 12 2012
12:00am - 2:00am
Hosted by: Contessa de la Luna
Share you secrets live on air Midnight Sundays 503-231-8187
12:00am - 2:00am
Hosted by: Contessa de la Luna
Talk Radio with La Contessa de la Luna. Guilt Shame Fear Forgiveness Minor Felonies 503-231-8187
5:30am - 7:00am
Hosted by: Diane Hunt, Gordon Euler, Jonathan Lay
Early morning folk music to get your week started. A different host each week.
7:00am - 8:00am
Hosted by: TBA
News magazine hosted by award-winning journalists Amy Goodman and Juan Gonzalez
8:00am - 9:00am
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Guests are Patricia and Darren Williams, evicted from their foreclosed home two weeks ago
9:00am - 10:00am
Hosted by: Bill Resnick, Clayton Morgareidge, Denise Morris, Frann Michel, Jan Haaken, Joe Clement, Larry Bowlden, Laurie Mercier, Old Mole
Post-Election strategy, Left and the Law: solitary confinement, Movie Moles: Detropia, Well-read red
10:15am - 11:00am
Hosted by: Barbara Bernstein
Why Alaskan Natives are bent on stopping the Pebble Mine in Bristol Bay, Alaska
11:30am - 12:00pm
Hosted by: Kathleen Stephenson
Making Contact presents "Women Rising #22: International Anti-Nuclear Activist"
12:00pm - 2:00pm
Hosted by: Retta Christie, Wade Hockett
Cowboy Country Hillbilly Western Swing and Old Jazz
2:00pm - 4:00pm
Hosted by: Ed Mellnik, Matthew Clark
The late night radio show that comes on in the afternoon.
4:00pm - 5:00pm
Hosted by: TBA
News magazine hosted by award-winning journalists Amy Goodman and Juan Gonzalez
5:00pm - 5:30pm
Hosted by: pmnews
Non-corporate, volunteer-powered, local, national, and international news
6:00pm - 6:30pm
Hosted by: Jamie Partridge, Maldelamer, portwalsh
Mexican Anti-Drug War Activist plus Vets Day Postal Rally
6:30pm - 7:00pm
Hosted by: acarpinelli, Carlos Chavez, Karen James, Peter Pincetl
Daniel Shea, Veterans & Incarceration
7:00pm - 8:00pm
Hosted by: Anita Johnson, Davey D, quincyhoist, Tsadae Abeba Neway, Weyland Southon
Daily Hip Hop Talk Show
8:00pm - 10:00pm
Hosted by: Alejandro Ceballos, Andy Hosch, ani, Danielle Parks, Dr. Zomb, Kathy F, lyn, Rich, Rolf Semprebon, Virginia Furr
3 leaders of the avant-garde in American 20th Century classical music


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Whelan, G.A., Nash, C.A, Preston, J.M. and Wardman, M.R. (1997) Passenger Rail Statistics Following the Privatisation of British Rail. Working Paper. Institute of Transport Studies, University of Leeds , Leeds, UK.
Full text available as:
ITS103_WP469_uploadable.pdf Available under License : See the attached licence file. Download (206Kb) |
In common with other major industries, the rail industry requires significant amounts of high quality information for successful operation. Information relating to the demand and supply of rail services is required to ensure that appropriate services are provided at minimum cost. Given the recent explosion of information technology, data on demand and supply is readily accessible and much improved. The benefits to the industry arising from such improvements should be maintained under the new organisational structures brought about by the 1993 Transport Act. It is the aim of this note to outline current sources of information and key statistics and raise the issue of what provisions are being made to ensure that they are maintained in a consistent and compatible format following privatisation.
Item Type: | Monograph (Working Paper) |
Copyright, Publisher and Additional Information: | Copyright of the Institute of Transport Studies, University Of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > Institute for Transport Studies (Leeds) |
Depositing User: | Adrian May |
Date Deposited: | 30 Mar 2007 |
Last Modified: | 08 Feb 2013 17:03 |
Published Version: | http://www.its.leeds.ac.uk/ |
Status: | Published |
Publisher: | Institute of Transport Studies, University of Leeds |
Identification Number: | Working Paper 469 |
URI: | http://eprints.whiterose.ac.uk/id/eprint/2120 |
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1 hr ago | KYTX-TV News
Monday's Weather: Dense Fog Advisory until 9 AM, high low 70s
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Aaron De La Cruz x Remix x Casio G-Shock GD-6900
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Business Watch: One boutique moves, another opens
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The Wrestling 5 and 1 3.09.14: Eve Torres Vs Melina
The Wrestling 5 & 1 3.09.14: Eve Torres Vs Melina Posted by Tony Acero on 03.09.2014 Kaitlyn is your "& 1" Model of the Week, Eve Torres battles Ashley Massaro Vs, thoughts about losing faith in wrestling, Bryan's position at WrestleMania, and more! Another day, another dollar.
Melton remembered for life of service to Macon
BEAU CABELL/THE TELEGRAPH Macon, Ga., 03/08/2014: Tommie Melton, at left, watches with family members as the flag draped casket of her husband former Macon Mayor Buck Melton is placed in a hearse after services at St. Paul's Episcopal Church.
Shop Macy's spectacular specials through Sunday, March 9
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Watching the Web for March 8, 2014
Welcome back to our weekly installment, where we have a quick look at some interesting watches and articles that have popped up over the last week, as well as taking a second look at what some of our more popular articles this week were.
Man charged with taking jewellery worth A 12,435 from two north Kent jewellers
Justin Quye, 37, of Northfield Path, Dagenham, appeared at Medway Magistrates' Court on Thursday charged with five counts of shoplifting and was remanded in custody.
Jewelry Ranks First as 'Investment of Passion' Among Ultra Wealthy
Jewelry is the top ''investment of passion'' for the world's wealthy this year, according to Knight Frank Research's ''The Wealth Report 2014.'
the Death Set Release New Music Video for 'Soar Away'
Pizza, babes, and roller blades. Can it get any better? Experimental art punkers The Death Set present their new music video for "Soar Away" off their recent King Babies EP, out now on Dim Mak Records.
Omega watch boutique coming to new Mall at University Town Center
Omega filed a building permit Friday for a 1,747-square-foot store inside the $315 million, 880,000-square-foot mall that's under construction at Cattlemen Road and University Parkway.
Brooklyn Startup Plays Manufacturing Matchmaker
Matthew Burnett is no stranger to American-made products. He learned the craft of watchmaking from his grandfather, who was a worker on Ford's Detroit assembly line for $5 a day.
Hiring surprisingly picked up in February
A new app will help keep track of your caffeine consumption and answer a key question: do you really need another cup of coffee? The Jawbone's Up Band has been around with much popularity for A new app will help keep track of your caffeine consumption and answer a key question: do you really need another cup of coffee? - Having trouble rolling out ... (more)
The Size Of The Smartwatch Market & Its Key Players
As a champion of the traditional mechanical watch industry I am also deeply interested in the still infant smartwatch industry.


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York County residents Light the Night
Remembrance ceremony held at Cousler Park in Manchester Township
UPDATED 9:40 AM EDT Oct 14, 2012Some York County residents spent Saturday evening paying tribute to the lives touched by Leukemia and Lymphoma.
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Is Hugh Jackman in danger of losing his buff body?
In an interview with NPR, the famously fit actor reveals he's been losing three to four pounds nightly from dancing in his new musical, "Hugh Jackman: Back on Broadway."
"We started a week ago," the 43-year-old Aussie said. "They've already taken my pants in three times."
Jackman, who once consumed 6,000 calories a day to beef up for his film role as Wolverine in the "X-Men" franchise, shares stories from his childhood and career in the Broadway show. He also incorporates anecdotes that feature his wife, Deborra-Lee Furness, and their two children, Oscar, 11, and Ava, 6. According to Jackman, they also happen to be his toughest critics.
"I said, 'Guys, I want you to be really honest. My feelings won't be hurt. You can say whatever, but I just want to know if you like the show or not. Do you enjoy it?'" Jackman recalled. "And my son goes, 'You know, Dad, I really like it.'"
The actor's daughter Ava was less amused. "My daughter said, 'I find it a little boring,'" Jackman laughed. "I said, 'Fair enough. You're 6; I get it!'"
PHOTOS: Hugh and other shirtless dads
Despite his family's criticism, Jackman said he's having a blast performing on the Great White Way. "I sometimes pinch myself that I'm getting the chance -- it's like ultimate karaoke."
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Finally, the match that is going to take place at Wrestlemania 29. Bill Goldberg himself has said that he and the WWE are negotiating at the moment, but Goldberg wants the Undertaker match and for him to have a guaranteed win, with a hall of fame induction. He's also pushing for a similar deal as Lesnar, WWE are talking with Goldberg due to trouble with Lesnar.
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Banking and Finance Courses
FINA 3001H: Financial Management (Honors)
The basic concepts and analytical tools of finance in both corporate finance and investments. Topics include risk and return, financial institutions, efficient markets, valuation theory, capital budgeting, portfolio theory, cost of capital, and international finance. Discussion and analysis of specific applications of these topics. For non-Terry College of Business students. Non-traditional format: Honors Program students meet for additional break-out sessions. Offered every year.
Not open to students with credit in FINA 3001 or FINA 3000 or FINA 3000H. Prerequisite: (ACCT 2101 or ACCT 2101H) and (MIST 2090 or MIST 2190H or CSCI 1100-1100L) and permission of Honors.
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You can share it to your friends, family, and colleagues, just like Chris did.
Chris ZimmermanDirector/COO, NanoBioTech Pharma Director/COO at NanoBioTech Pharma, a company redefining paradigms about health and aging. NanoBiotech sells both nutraceutical and pharmaceutical products that treat and reverse pathological calcification in people, effectively treating heart disease, diseases of the kidneys and prostate, psoriasis, immunological/inflammatory diseases and many more. On the web at http://www.NanoBioTech.us Founded GSIP, a real estate development and management firm specializing in asset repositioning and green development. I love architecture - buildings, houses, you name it, I have a passion for design and building. I am also a longtime martial artist and practitioner of Chinese medicine (Tui Na). I haven't worked at it professionally in a long time but I maintain my skill and still treat the occasional friend or family member when I need to. I am an avid reader, I like books on science, spirituality, philosophy and business and some occasional fiction. I also love travel, music, and great food! Happily married (to Jaci), dad to amazing 11 year old son (Daniel), live and work on the East Coast.
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Delete NSFW Hooplah Jun 29, 2013 at 09:08PM EDT in reply to The Grand Master Baller Sure thing, friend. How about black Natalie Portman: or how about black Angelina Jolie: and finally…white Bill Cosby:The horror. +11 Reply
Delete NSFW The Grand Master Baller Jun 29, 2013 at 08:13PM EDT This is so fucking unsettling. I need more. +6 Reply


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Your favorite Apple, iPhone, iPad, iOS, Jailbreak, and Cydia site.
Thread: Business card reader: ScanCard vs WorldCard
is a discussion within theApple AppStore App Discussion
forums, a part of the3rd Party Apps For iPhone | iPod Touch
section;Business Card reader is a great way to reduce the amount of paper cards that you have to follow. Just scan them into your iPhone with the camera and the
08-07-2013, 02:12 AM #1Business card reader: ScanCard vs WorldCard
Business Card reader is a great way to reduce the amount of paper cards that you have to follow. Just scan them into your iPhone with the camera and the application will just transfer your paper cards into contact in your iPhone. Before, I've used WorldCard. This time, I tried ScanCard.
WorldCard works ok for me but the recognition rate is not good enough for me, though the UI is flat design and beautiful. Since I tried ScanCard, I find it almost recognize my every business card correctly, only rare times I need to correct things. The UI is more business style, different from WorldCard. Compare to the price, WorldCard is 6.99$, while ScanCard is 4.99$. For management and search, both application is convenient and quick. But I prefer ScanCard for better Google Maps support for locations.
ScanCard: https://itunes.apple.com/us/app/scan...458040969?mt=8
WorldCard: https://itunes.apple.com/us/app/worl...333211045?mt=8


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1. (imp. & p. p.) of Mind.
2. (a.) Disposed; inclined; having a mind.
Minded (36 Occurrences)
Matthew 1:19 Then Joseph her husband, being a just man, and not willing to make her a publick example, was minded to put her away privily. (KJV ASV)
John 1:43 On the morrow he was minded to go forth into Galilee, and he findeth Philip: and Jesus saith unto him, Follow me. (ASV)
Acts 5:33 But they, when they heard this, were cut to the heart, and minded to slay them. (ASV)
Acts 15:37 And Barnabas was minded to take with them John also, who was called Mark. (ASV)
Acts 18:15 but if they are questions about words and names and your own law, look to it yourselves; I am not minded to be a judge of these matters. (ASV)
Acts 18:27 And when he was minded to pass over into Achaia, the brethren encouraged him, and wrote to the disciples to receive him: and when he was come, he helped them much that had believed through grace; (ASV YLT)
Acts 19:30 And when Paul was minded to enter in unto the people, the disciples suffered him not. (ASV)
Acts 27:39 And when it was day, they knew not the land: but they discovered a certain creek with a shore, into the which they were minded, if it were possible, to thrust in the ship. (KJV DBY)
Acts 28:18 who having examined me were minded to let me go, because there was nothing worthy of death in me. (DBY)
Romans 8:6 For to be carnally minded is death; but to be spiritually minded is life and peace. (KJV WBS)
Romans 9:22 And if God, minded to shew his wrath and to make his power known, endured with much long-suffering vessels of wrath fitted for destruction; (DBY)
1 Corinthians 10:27 But if any one of the unbelievers invite you, and ye are minded to go, all that is set before you eat, making no inquiry for conscience sake. (DBY)
2 Corinthians 1:15 And in this confidence I was minded to come unto you before, that ye might have a second benefit; (KJV ASV)
2 Corinthians 1:17 When I therefore was thus minded, did I use lightness? or the things that I purpose, do I purpose according to the flesh, that with me there should be yea yea, and nay nay? (KJV ASV WBS)
Galatians 5:10 I have confidence in you through the Lord, that ye will be none otherwise minded: but he that troubleth you shall bear his judgment, whosoever he be. (KJV ASV WBS YLT)
Philippians 1:7 even as it is right for me to be thus minded on behalf of you all, because I have you in my heart, inasmuch as, both in my bonds and in the defence and confirmation of the gospel, ye all are partakers with me of grace. (ASV)
Philippians 3:15 Let us therefore, as many as be perfect, be thus minded: and if in any thing ye be otherwise minded, God shall reveal even this unto you. (KJV ASV DBY WBS RSV)
1 Timothy 6:9 But they that are minded to be rich fall into a temptation and a snare and many foolish and hurtful lusts, such as drown men in destruction and perdition. (ASV)
Titus 1:8 but given to hospitality, as a lover of good, sober minded, fair, holy, self-controlled; (WEB WEY ASV BBE YLT)
Titus 2:2 that older men should be temperate, sensible, sober minded, sound in faith, in love, and in patience: (WEB WEY ASV)
Titus 2:5 to be sober minded, chaste, workers at home, kind, being in subjection to their own husbands, that God's word may not be blasphemed. (WEB ASV)
Titus 2:6 Likewise, exhort the younger men to be sober minded; (WEB KJV ASV BBE WBS YLT)
Hebrews 6:17 Wherein God, being minded to show more abundantly unto the heirs of the promise the immutability of his counsel, interposed with an oath; (ASV)
James 1:8 He is a double-minded man, unstable in all his ways. (WEB KJV ASV DBY NAS NIV)
James 4:4 Adulteresses, know ye not that friendship with the world is enmity with God? Whoever therefore is minded to be the friend of the world is constituted enemy of God. (DBY)
James 4:8 Draw near to God, and he will draw near to you. Cleanse your hands, you sinners; and purify your hearts, you double-minded. (WEB KJV ASV DBY WBS NAS NIV)
1 Peter 3:8 Finally, be all like-minded, compassionate, loving as brothers, tenderhearted, courteous, (WEB WEY ASV DBY)
1 Peter 4:7 But the end of all things is now close at hand: therefore be sober-minded and temperate, so that you may give yourselves to prayer. (WEY YLT NIV)
Ruth 1:18 When she saw that she was steadfastly minded to go with her, she left off speaking to her. (WEB KJV JPS ASV DBY)
1 Samuel 2:25 If one man sin against another, God shall judge him; but if a man sin against Yahweh, who shall entreat for him?" Notwithstanding, they didn't listen to the voice of their father, because Yahweh was minded to kill them. (WEB ASV DBY)
1 Chronicles 22:7 And David said to Solomon, As for me, my son, I was minded to build a house unto the name of Jehovah my God. (DBY)
2 Chronicles 11:22 Rehoboam appointed Abijah the son of Maacah to be chief, even the prince among his brothers; for he was minded to make him king. (WEB JPS ASV)
2 Chronicles 24:4 It happened after this, that Joash was minded to restore the house of Yahweh. (WEB KJV JPS ASV DBY WBS)
2 Chronicles 32:2 And when Hezekiah saw that Sennacherib was come, and that he was minded to fight against Jerusalem, (DBY)
Ezra 7:13 I make a decree, that all those of the people of Israel, and their priests and the Levites, in my realm, who are minded of their own free will to go to Jerusalem, go with you. (WEB KJV JPS ASV)
Jonah 4:2 And he prayed unto Jehovah, and said, Ah, Jehovah, was not this my saying when I was yet in my country? Therefore I was minded to flee at first unto Tarshish; for I knew that thou art a gracious ?God, and merciful, slow to anger, and of great loving-kindness, and repentest thee of the evil. (DBY)


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You're leaving Wedding Paper Divas to see the Deal of the Day at our parent site, Tiny Prints.
"I opened up the sample box and this was the first one out. It really is fab! Heavy paper that gives it that importance that you need. Wonderful beach colors and design!"
"This invitation is unique and entirely charming. The flowers on the front and back look like chalk drawings, which will be easy to replicate on chalk boards at our reception. In person, the invitation looks luxe and super personal - as if we had it designed just for us. We added text to the back at the invitation at no extra charge, which was a huge bonus. I'd highly recommend this design."
"I loved these as our wedding invitations, we based our entire wedding colours around them. They fit our day perfectly and turned out even more beautiful than i had expected"
"I ordered this as a sample although it didn't really fit my theme. Not doing the "natutical" route...but oh boy...if I was I would be ordering these right now. This invite is adorable and absolutely fun. This is a perfect fit for a casual beach wedding."
"These wedding invitations were such good quality. They were perfect to match my perfect fall wedding. They were definitely worth the price. I love how this website saves your projects because I needed more and was able to just go in and place the same order over again with ease. I recommend Wedding paper divas to all. Very good high quality products."


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RMA'd motherboard, where to next if it comes back good?
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Welcome the warm weather with hospitality and spirit with our classic outdoor patio and deck sets. We feature an award winning selection of minimalist, classic, traditional, and every style in between. All weather sectionals, modular bistro sets, slatted tables and chairs, rattan furniture, Adirondack and mission styles are only some examples of our vast inventory. We have it all!
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Coping with Cervical Cancer
By Lisa Fayed
Cervical cancer is a tough battle to fight for any woman. Every single facet of life is disrupted the minute a woman is diagnosed with cervical cancer. These changes can be difficult to manage. But with the help of friends, family, and other support mechanisms, women can and do cope with cervical cancer.
- Support for Women with Cervical Cancer
- Dealing with Depression During Treatment
- Supporting a Loved One with Cervical Cancer
- Daily Living Expectations and Tips
Support for Women with Cervical Cancer
Support can come in many forms. From friends and family to cancer support groups, discover how to get the support you need during treatment.
Dealing with Depression During Treatment
Depression is common among women who have cervical cancer. Learn how to prevent and manage depression during cancer treatment.
Supporting a Loved One with Cervical Cancer
When a friend or family member has been diagnosed with cervical cancer, it is natural to want to give support. Learn how you can give effective support while staying strong for your loved one.
Daily Living Expectations and Tips
When you have cervical cancer, daily living activities may be difficult. Through tried and true tips and hints, learn how to maintain daily activities during treatment and its side effects.


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Customers having peace of mind
I have been using Nayatel since May 2013, and truly speaking i have never face any problem in internet and cable services. This best thing is Nayatel staff they are the most cooperative crew i have ever seen. Nayatel is a real value for money. i would recommend every one to please switch to Nayatel for the best services.
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I'm very thankfull to nayatel team , i'm online teacher i used every available network in 1sb/rwp. Then i found nayatel and im useing it since jan 2012 i'm very satisfied with service. Keep it up.
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I am using Nayatel now for 3 months and i will rate them ten out of 10. Their quality of service is excellent and services such as ivod and live tv make the experience even more interesting. Great job guys keep up the good work.
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Just want to wish the Nayatel team a Happy 2014, and extend a big thank you for your excellent service. I live in Dubai and for the past 5 years my Nayatel connection back home in Islamabad has been running smoothly for whenever the kids and I are home and need to use it. Despite my long absences from Islamabad, when I come home I am greeted with a fully functional network and, if at all there is an issue, I receive service in record time. In Dubai, where facilities are extensive, I do not get the quality of service form the providers as I do in Islamabad from Nayatel. Excellent work….thanks!
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Campus Life |
Student | Total |
American Indian/Alaskan Native | 0.5% |
Asian/Pacific Islander | 3.2% |
Black/non-Hispanic | 9.8% |
Hispanic | 4.6% |
Non-resident alien | 4.9% |
Race/Ethnicity unknown | 13.9% |
Two or more races | 0.0% |
White/non-Hispanic | 63.1% |
Disabilities | |
Percent of students with disability | 3% or less |
Services Offered
Arrests On Campus | |
Illegal Weapons Possession | 0 |
Drug Law Violation | 0 |
Liquor Law Violation | 0 |
Criminal Offenses On Campus | |
Personal Crime | 1 |
Property Crime | 15 |
The dorms are awesome. They are a great way to make new friends and really feel like a big UArts community. School spirit is at its finest in this area.…
I do not know what dorm life is like on campus. I am married and commute to school on days i have classes.…
Dorms are only guaranteed for incoming freshmen; once you become an upperclassman you either have to find an apartment, which is what most people do, or enter the housing lottery.…
The campus is beautiful and the student are very diverse so you are bound to have a very well rounded experience.…
Have not yet lived it, therefor, I have no idea.…
I was a sophomore when they implemented the dining hall services at UArts. To be honest I am not a big fan of their dining experience. I personally enjoy food shopping in the city, making my own food and eating at local eateries around the city.
Read MoreThe food was good for the first month, but gets really repetitive and gets really boring. But food is food, and it is better than nothing. I suggest you to not get a meal plan, simply because the food tastes really plain.
Read MoreThe food is pretty gourmet most of the time. You can never be hungry food is always there. Buy your own food sometimes but use the dining hall to save money. Lunch and breakfast are the bedtimes to eat in there. Late night when your hungry hit up Mangia the late night dining hall.
Read MoreThe food isn't of bad quality, and they usually have some different options, but sometimes it can get a bit repetitive. The dining staff are all extremely friendly and kind though.
Read MoreI like the restaurants and servings around the school, but not recommend the dining food from school...
Read MoreThe food and dining the college offers isn't that great.
Read MoreThe Terra Dining Hall is a nightmare. It is hard to be healthy. There is a vegan/vegetarian section, but it is confusing and annoying. There is a salad bar but there are very few options. Breakfast is good. It is hard to be healthy, and usually they just make burgers. Students have petitioned, and there has been some improvement. Then again, the dining hall is brand new so I assume that it will improve.
Read MoreOutside of the university itself, the wonderful city of Philadelphia provides many options for dining and exploring unique and diverse cultures.
Read MoreWe have three dining halls and really convent hours so you can miss one meal time and still not miss a meal and the Food is really Good.
Read MoreThe dining hall Terra is far from spectacular, but the food is edible. They have a variety of foods, including vegetarian and vegan options. There are also two other smaller dining areas in other building the offer quick service food such as pizza and sandwiches.
Read MoreNone.
Read MoreGreek? Like Mythology? JK. No Greek life.
Read Morethere are a few but they just started so its to soon to say anything.
Read MoreThere is currently no Greek Life at the University.
Read MoreNone
Read MoreNonexistent. But there is Alpha Psi Omega, a theatre honor society, for any theatre major wanting to have a little taste of semi-greek life.
Read MoreThere is one fraternity that is apart of the theater school.
Read MoreSouth street has Greek celebrations.
Read Morenone
Read More


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Epic Adam Scott meldown hands British Open to Ernie Els
South African Ernie Els won the 2012 British Open after tournament leader Aussie Adam Scott bogeyed the last four holes. Els was apologetic in his victory over his friend, Adam Scott.
Lytham St. Annes, England
If this had been a normal British Open, Ernie Els would've been hanging out on the putting green hoping his work was done. Any other time, he wouldn't have welcomed a playoff to secure the title.
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The Big Easy was willing to make an exception this time.
There was nothing normal about a wind-swept Sunday at Royal Lytham & St. Annes.
"Crazy, crazy, crazy," Els kept saying.
Crazy, indeed. And, for the guy who let it slip away, a gut-wrenching blow.
RECOMMENDED: Are you a real golf fan? Take the Majors quiz
Adam Scott had the claret jug in his grasp with four holes to play. A player of enormous potential was poised to fulfill his promise at age 32, to collect the first major championship of his career after building a comfortable lead over three days of brilliant golf.
Then, a bogey. And another. And another. And finally, at the 18th hole, with a 7-foot putt to at least force a playoff, he missed again. Scott's knees buckled. Golf's oldest championship had been snatched away, handed to Els with one of the great collapses in golfing history.
"You're not really hoping the guy is going to make a mistake, but you're hoping you don't have to go to a playoff," said Els, who was playing two groups ahead of Scott. "This one was different because I feel for Adam. I really didn't mind going to a playoff. He probably didn't feel that. But I was, at best, hoping for a playoff on the putting green."
When it was done, Scott had to make a painful walk back to the 18th green to collect the prize that goes to the runner-up. On the table was the silver chalice that should've been his.
He gave it to Els on a silver platter.
The winner hardly sounded like one. In fact, Els was downright apologetic about the way it happened.
"Sorry," he said, looking toward a glassy eyed Scott. "You're a great player, a great friend of mine. I feel very fortunate. You're going to win many of these."
Scott certainly has plenty of years to capture a major. He's just coming into what should be the prime of his career. But no one really knows how he'll bounce back from such a bitter disappointment.
He has joined the infamous list of epic meltdowns, his name now etched alongside the likes of Jean Van de Velde and Ed Sneed and, yes, Greg Norman, his Aussie countryman and childhood hero.
"I played so beautifully all week," Scott said. "I shouldn't let this get me down."
But how could he not?
Scott can only hope he doesn't turn out to be another Van de Velde or Sneed, players who had their one shot at glory and never came close again.
Els tried to be encouraging.
"I told him, 'I've been there many times and you've just got to bounce back quickly. Don't let this thing linger,'" said Els, who added a second Open title to a pair of U.S. Open crowns. "I feel for him. But thankfully he's young enough. He's 32 years old. He's got the next 10 years that he can win more than I've won. I've won four now. I think he can win more than that."
Assuming he can get over this.
Scott, who went into the final round with a four-stroke lead after three straight rounds in the 60s, got off to a wobbly start with two bogeys on the first three holes. But the breeze off the Irish Sea — nonexistent through the first three rounds — blew everyone else away. Everyone but Els, that is, a guy who hadn't won in more than two years, a guy whose best golf seemed behind him.
Tiger Woods made a triple-bogey at the sixth, forced to take one swing while sitting on the grass next to a bunker. In one wayward hole, he lost any chance of rallying to win a 15th major title and end a more than four-year drought since his last big win.


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SummaryInnate lymphoid cells (ILCs) are a recently described group of innate immune cells that can regulate immunity, inflammation, and tissue repair in multiple anatomical compartments, particularly the barrier surfaces of the skin, airways, and intestine. Broad categories of ILCs have been defined based on transcription factor expression and the ability to produce distinct patterns of effector molecules. Recent studies have revealed that ILC populations can regulate commensal bacterial communities, contribute to resistance to helminth and bacterial pathogens, promote inflammation, and orchestrate tissue repair and wound healing. This review will examine the phenotype and function of murine and human ILCs and discuss the critical roles these innate immune cells play in health and disease.
Summary | Full Text | PDF (1300 kb) - RORγt Innate Lymphoid Cells Acquire a Proinflammatory Program upon Engagement of the Activating Rece...
RORγt Innate Lymphoid Cells Acquire a Proinflammatory Program upon Engagement of the Activating Receptor NKp44
Immunity, Volume 38, Issue 6, 27 June 2013, Pages 1223-1235
Timor Glatzer, Monica Killig, Johannes Meisig, Isabelle Ommert, Merlin Luetke-Eversloh, Marina Babic, Daniela Paclik, Nils Blüthgen, Rainer Seidl, Claudia Seifarth, Jörn Gröne, Minoo Lenarz, Katharina Stölzel, Dominik Fugmann, Angel Porgador, Anja Hauser, Alexander Karlas and Chiara Romagnani
SummaryRORγt+ innate lymphoid cells (ILCs) are crucial players of innate immune responses and represent a major source of interleukin-22 (IL-22), which has an important role in mucosal homeostasis. The signals required by RORγt+ ILCs to express IL-22 and other cytokines have been elucidated only partially. Here we showed that RORγt+ ILCs can directly sense the environment by the engagement of the activating receptor NKp44. NKp44 triggering in RORγt+ ILCs selectively activated a coordinated proinflammatory program, including tumor necrosis factor (TNF), whereas cytokine stimulation preferentially induced IL-22 expression. However, combined engagement of NKp44 and cytokine receptors resulted in a strong synergistic effect. These data support the concept that NKp44+ RORγt+ ILCs can be activated without cytokines and are able to switch between IL-22 or TNF production, depending on the triggering stimulus.
Summary | Full Text | PDF (4822 kb) - Regulation of Cytokine Secretion in Human CD127 LTi-like Innate Lymphoid Cells by Toll-like Receptor...
Regulation of Cytokine Secretion in Human CD127 LTi-like Innate Lymphoid Cells by Toll-like Receptor 2
Immunity, Volume 33, Issue 5, 24 November 2010, Pages 752-764
Natasha K. Crellin, Sara Trifari, Charles D. Kaplan, Naoko Satoh-Takayama, James P. Di Santo and Hergen Spits
SummaryLymphoid tissue inducer cells are members of an emerging family of innate lymphoid cells (ILC). Although these cells were originally reported to produce cytokines such as interleukin-17 (IL-17) and IL-22, we demonstrate here that human CD127+RORC+ and CD56+CD127+ LTi-like ILC also express IL-2, IL-5, and IL-13 after activation with physiologic stimuli such as common γ-chain cytokines, Toll-like receptor (TLR) 2 ligands, or IL-23. Whereas TLR2 signaling induced IL-5, IL-13, and IL-22 expression in a nuclear factor κB (NF-κB)-dependent manner, IL-23 costimulation induced only IL-22 production. CD127+ LTi-like ILC displayed clonal heterogeneity for IL-13 and IL-5 production, suggesting in vivo polarization. Finally, we identified a role for autocrine IL-2 signaling in mediating the effects of TLR2 stimulation on CD56+CD127+ and CD127+ LTi-like ILC. These results indicate that human LTi-like ILC can directly sense bacterial components and unravel a previously unrecognized functional heterogeneity among this important population of innate lymphoid cells.
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Copyright © 2010 Elsevier Inc. All rights reserved.
Immunity, Volume 32, Issue 6, 734-736, 25 June 2010
Add/View Comments (0)An IL-1β-Dependent Switch in Innate Mucosal Immunity?
1 Innate Immunity Unit, Institut Pasteur, F-75724 Paris, France
2 Inserm U668, F-75724 Paris, France
- The mechanisms that guide the development of mucosal-associated innate lymphoid cells (ILCs) producing IL-17, IL-22, and IFN-γ are the subject of intense interest. In this issue of Immunity, Hughes et al. (2010) identify a new role for IL-1β in regulating an IL-22-producing ILC.


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Dual Loyalty: Why Did a Neocon Vote in Both Israel and U.S.?
When attacking the ideology of the neoconservatives, the big enchildada is dual loyalty: in their hearts, do they feel allegiance to Israel? Gabriel Schoenfeld of Commentary Magazine said that this was the clear thrust of Walt and Mearsheimer's paper, they were accusing supporters of Israel of being a fifth column. W&M Read More


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