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US 5725875 A Abstract A protective cream composition contains 15 to 40 wt % of an alkali metal fatty acid salt having from 8 to 18 carbon atoms, an effective amount of a topical agent such as an antimicrobial compound, 5 to 20 wt. % of a polyol effective as an emollient, 0.5 to 8.0 wt. %, of an alkali metal silicate, and the balance water. Such a composition can be applied to the skin to protect health care workers and other from infection. The cream dries to form a topical barrier on the skin, and also contains an agent effective against, for instance, viruses such as human HIV. Once a medical operation is completed, the film formed from the dried cream can be washed off with soap and water. Other topical agents present in the composition include, for instance, suncreens, insect repellents and chemical repellents.
Claims(21) 1. A protective skin cream composition consisting essentially of:
(i) 15 to 40 wt. % of an alkali-metal fatty acid salt having from 8 to 18 carbon atoms, (ii) an effective amount of an antimicrobial compound, (iii) 5 to 20 wt. % of a polyol effective as an emollient, (iv) 0.5 to 8.0 wt. % of an alkali metal silicate, and (v) the balance water, said composition being removable with soap and water; wherein the antimicrobial compound is effective against viruses. 2. The composition of claim 1, wherein the cream is in the form of an oil-in-water emulsion.
3. The composition of claim 1, wherein the polyol is selected from the group consisting of glycerin, sorbitol and propylene glycol, and the alkali metal silicate is sodium or potassium silicate.
4. The composition of claim 1, wherein the antimicrobial compound is AZT or nonylphenoxy-polyethoxyethanol.
5. A method of protecting a person from infection from bodily fluids, which comprises:
(1) applying to the skin of said person a protective skin cream composition of claim 1, which composition dries to form a film on the skin effective as a topical barrier against bodily fluids, the film containing the antimicrobial compound in an amount effective to kill one or more types of microbial organisms, and the film being removable with soap and water; (2) wearing the film while performing a task in close proximity to said bodily fluids; and (3) removing the film from said person's skin upon completion of a task with soap and water. 6. The method of claim 5, wherein the task comprises a surgical operation or procedure on a patient having blood.
7. The method of claim 6, wherein the blood of the patient is contaminated with HIV.
8. The method of claim 6, wherein the surgical operation or procedure involves contact between the blood of the patient and a worker performing said task.
9. The method of claim 6, further comprising a step of putting on a protective garment over skin to which the protective composition has been applied.
10. The method of claim 6, further comprising the steps of putting on protective garments, and applying the protective composition to exposed areas of skin.
11. The method of claim 9, further comprising applying the protective composition to the face of a worker.
12. The method of claim 5, further comprising performing steps (1) to (3) two or more times during the same day.
13. A protective skin cream composition consisting essentially of:
(i) 15 to 40 wt. % of an alkali-metal fatty acid salt having from 8 to 18 carbon atoms, (ii) an effective amount of topical bioactive agent, (iii) 5 to 20 wt. % of a polyol effective as an emollient, (iv) 0.5 to 8.0 wt. % of an alkali metal silicate, and (v) the balance water, said composition being removable with soap and water. 14. A method of protecting a person which comprises:
(1) applying to the skin of said person a protective skin cream composition of claim 13, which composition dries to form a film on the skin effective as a topical barrier, the film containing the topical bioactive agent and the film being removable with soap and water; (2) wearing the film; and (3) removing the film from said person's skin with soap and water. 15. A protective skin cream composition consisting essentially of:
(i) 15 to 40 wt. % of an alkali-metal fatty acid salt having from 8 to 18 carbon atoms, (ii) 5 to 20 wt. % of a polyol effective as an emollient, (iii) 0.5 to 8.0 wt. % of an alkali metal silicate, and (iv) the balance water, said composition being removable with soap and water. 16. A method of protecting a person which comprises:
(1) applying to the skin of said person a protective skin cream composition of claim 15, which composition dries to form a film on the skin effective as a topical barrier, and the film being removable with soap and water; (2) wearing the film; and (3) removing the film from said person's skin with soap and water. 17. The composition of claim 13, wherein an effective amount of a detecting agent for determining that a body fluid is present is added.
18. The composition of claim 13, wherein said composition is an aerosol dispensed gel.
19. The composition of claim 13, wherein said topical agent is microencapsulated.
20. The composition of claim 15, wherein said composition delays the passage of radio labeled virus by up to 30 minutes.
21. The composition of claim 15 wherein said composition delays the passage of radio labeled virus by up to 20 minutes.
Description This application is a 371 of PCT/US94/00304 Jan. 10, 1994. This invention relates to a protective composition, more particularly to a skin cream of the kind that forms a protective film on skin or other surfaces. Many known antimicrobial topical compositions are designed for treatment of existing wounds or skin disorders, and are not used as barriers to future infectious contact. These topical agents penetrate the wound or infected area, and deliver the antimicrobial compound to the site of the contamination. Many of these commercially available topical formulations consist of an oil based carrier such as petrolatum or liquid paraffin which is insoluble or nearly insoluble in water, plus a bioactive agent. Such compositions tend to be greasy, tacky, stain causing, and may be difficult to remove. Specific topical bioactive skin ointments used to treat infections are described, for example, in Edwards U.S. Pat. No. 4,803,066, issued Feb. 7, 1989, and Holtshousen U.S. Pat. No. 4,671,957, issued Jun. 9, 1987. Other antimicrobial surface-coating compositions have been formulated for the coating of substrates such as wood, metal, textile, thread, canvas, carpeting, paper and masonry. Most of these compounds are long lasting, toxic, irritating to skin, and not easily removable. Many are formulated to provide a semi-permanent polymer coating. Ona et al. U.S. Pat. No. 4,614,675, issued Sep. 30, 1986, and Baldwin U.S. Pat. No. 4,467,013, issued Aug. 21, 1984, describe an antimicrobic used to treat fibers, fiber-containing material and non-woven fabrics. Mustachich et al. U.S. Pat. Nos. 4,479,795 and 4,343,788 describe a carboxylate antimicrobial agent releasably incorporated into permeable polymers. Young et al. U.S. Pat. No. 4,500,338, issued Feb. 19, 1985, discloses a hydrolyzable organic titanium compound containing a microbiocide and an optional organopolysiloxane for use as a surface disinfectant. Other prior art has focused on the incorporation of an antimicrobial agent into surface coating substances such as paints or varnishes to prevent the decomposition of the surface coating. Deinet et al. U.S. Pat. No. 4,448,906, issued May 15, 1994, Dandt et al. U.S. Pat. No. 4,404,196, issued Sep. 13, 1983, Sidi et al. U.S. Pat. Nos. 4,022,906, issued May 10, 1977, 4,012,261, issued Mar. 15, 1977, 3,962,271, issued Jun. 8, 1976, 3,952,000, issued Apr. 20, 1976, 3,890,264, issued Jun. 17, 1975, and Minieri U.S. Pat. No. 3,929,705, issued Dec. 30, 1975 all describe such inventions. In the field of protective hand creams, one composition marketed under the Invisible Glove trademark is made of about 60% water, 14% glycerin, 1% sodium silicate, and 25% soap (sodium laurate). This composition has been commercially successful as a cream applied prior to undertaking a task that involves exposing the hands to inks, grease, paints or the like. The cream dries to form a thin, slightly tacky film on the hands that repels contaminants. Mattson et al. U.S. Pat. No. 4,738,987 discloses a comparable skin care composition compounded as a dispersion of water with soap, a water-soluble alkali metal silicate, and sulfonated castor oil having a pH adjusted with acid to 6.5 to 10. See also Morgulis U.S. Pat. No. 2,698,824, issued Jan. 4, 1955, which describes a non-bioactive silicone-based ointment which provides a non water soluble protective layer on the skin. These compositions tend to fall into one of several categories: compositions containing an antimicrobial designed for immediate use on the skin, compositions containing an antimicrobial and an agent such as a siloxane to provide extended substantivity on the skin, and compositions for temporary use (i.e., which wash off readily with soap and water) but which lack an antimicrobial. None are particularly suited for protecting health care workers. During surgery, doctors and health care workers are commonly exposed to the blood or other bodily fluids of the patient. Protective gowns, masks and gloves may not provide adequate protection of all exposed skin areas, and may hinder delicate operations. A need exists for a skin protectant composition that can be worn under of protective clothing and on skin which remains exposed, which composition minimizes the chance that a health care worker will contract AIDS, sexually transmitted disease, or other infectious diseases. However, the composition should be readily removable when a procedure or operation is over so that the physician or health care worker can wash it off and remove any residual contamination. The present invention addresses this need. This invention provides a protective composition, particularly a skin cream, from formulations of an aqueous base, preferably an oil-in-water emulsion, containing a topical bioactive agent such as an antimicrobial agent. A preferred protective composition according to the invention contains, as basic ingredients, an alkali-metal fatty acid salt, a topical bioactive agent such as an antimicrobial agent, an alkali-metal silicate, and water. In particular, a preferred skin cream which provides a barrier from viruses, bacteria and other microorganisms consists essentially of 15 to 40 wt. % of an alkali metal fatty acid salt having from 8 to 18 carbon atoms, an effective amount, generally about 0.1 to 15.0 wt. %, of an antimicrobial compound, 0.5 to 8.0 wt. % of an alkali-metal silicate, up to 20 wt. % of a polyol effective as an emollient and/or viscosity adjusting agent, and the balance water. In each case, weight percent amounts are based on the weight of the total composition. Such a composition dries quickly on the skin and forms a film that repels liquids and also kills "germs" that might otherwise survive to eventually penetrate the barrier. According to a further aspect of the invention, the foregoing composition is used in carrying out one or a series of surgeries or medical procedures. The subject applies the cream according to the invention to his or her skin in likely exposed areas, such as hands, face and upper body, puts on protective clothing, and performs the operation or procedure. After the operation is over, for example, the subject washes the film left by the cream off. If a further operation is scheduled, the cream can then be freshly reapplied without danger of residual contamination from the prior operation. These and other aspects of the invention are more fully described below. The present invention is further directed to a protective skin composition wherein the antimicrobial agent is substituted by or used in combination with a topical bioactive agent such as a sunscreen, moisturizer, chemical repellant, insect repellant, and other topical pharmaceuticals and the like. All of these various active ingredients may be used alone or in combination with one another. In another embodiment of the invention, the composition may be used as a barrier per se. Under these circumstances, the presence of a topical bioactive agent is not required. FIG. 1 shows data plotted as a percent of the control and demonstrates how much virus passes through the composition of the invention with the passage of time. FIG. 2 shows how much radiolabeled virus passes through a filter coated with the composition of the invention with the passage of time. As discussed above, a need exists for a topical barrier containing, for instance, a microbiocide that provides protection by direct application to exposed skin and may be easily removed with water. The composition of the invention may be used as protection against microorganisms, viruses, insect bites, sun, poison ivy/oak, burns and other skin irritants. A composition for administration to the skin to form an adherent, continuous, flexible coat should serve two purposes: (1) it should form a barrier against infection, and (2) it should serve as an effective vehicle for one or more topical bioactive agents, such as antimicrobial agents that destroy infectious organisms that come in contact with the topical barrier. Such a composition could be used in place of gloves in some circumstances, or may be used to provide an extra measure of protection underneath gloves or on areas the gloves do not cover, such as the forearms, and would be of immense use to individuals such as health care workers, police, fire and rescue personnel, and anyone else who is at risk of exposure to infectious bodily fluids. This invention can be used in place of latex gloves or beneath gloves to help prevent allergic reactions to persons sensitive to latex or other rubber or synthetic rubber products, including patients and health care workers. Ideally, a skin cream should be non-toxic, without side effects, non-irritating, non-greasy, non-tacky, odorless, easy to apply, easy to remove, and provide excellent protection from infection. It should provide an effective barrier for an extended time (for example, up to 4 hours, preferably up to 24 hours) or until removed. The present invention can provide these characteristics to a greater extent than many prior preparations. The phrase "bioactive agent" refers to a compound which protects or otherwise benefits the skin of a human or animal when applied topically to the skin. The term "skin" refers to all human or animal external surfaces including the epidermis, mucous membranes, cornea, nails, teeth and hair. While many applications will be limited to the epidermis, nails and hair for toxicological reasons, applications for the other surfaces are contemplated. Representative examples of various topical bioactive agents which may be used in the present invention include the following topical bioagents shown in Table 1. However, the invention is not limited to the topical bioagents listed below. TABLE 1______________________________________Topical Agent______________________________________A. AntimicrobialsPhenol ##STR1##Cresol (o,m,p) ##STR2##Hydroxy-Benzoates ##STR3##Resorcinol/4-hexylresorcinol ##STR4##Hexachlorophene ##STR5##Triclosan ##STR6##Salicylanilide ##STR7##Tetracycline ##STR8##(Quinolones)Peptides and Derivatives:Bacitracin,Gramicidin,Polymyxin B ##STR9##Glycosidic:Streptomycin B,Neomycin A,Erythromycin,Gentamicin ##STR10##Others:Chlorhexidine ##STR11##Thiols/Antidandruff pyrithione ##STR12##Imidazoles/Antifungals miconazole ##STR13##Topical Germicidals such as Acids/Surfactants ##STR14##Mercurials such as thimersal ##STR15##Ureas such as triclocarban,cloflucarban ##STR16##Penicillins ##STR17##Quaternary ##STR18##B. SunscreensBenzoates ##STR19##Oxybenzone (dioxy) ##STR20##Cinnamic Acid Derivatives ##STR21##C. Insect Repellents1,3-Hexanediol ##STR22##Citronellal ##STR23##Toluamide ##STR24##D. Humectants/MoisturizersPolyols such as Glycerol,Polyethylene glycolHyaluronic acid ##STR25##or ##STR26##E. Skin ProtectantsSilicones ##STR27##Perfluorocarbons ##STR28##Allantoin ##STR29##Methyl Silylates ##STR30##F. Skin Penetration EnhancersCaprolactams ##STR31##Sulfoxides ##STR32##G. Anti-Inflammatory AgentsCorticosteriods ##STR33##Salicylates ##STR34##H. Anti-Allergy AgentsCromolyn ##STR35##PentigitideASPSERASPPROARGI. Hair Growth AgentsMinoxidil ##STR36##J. Skin EmollientsAlcoholsROHCetyl AlcoholGlyceryl HydroxystearatePPG- and PEG- MonoestersK. AntioxidantsAscorbates ##STR37##Gallates ##STR38##Thiocompounds ##STR39##L. Hair Conditioning AgentsProteins and Amino AcidsROHHydroxylated FatsDihydroxyethyl- Amine Oxide (or Glycinate) ##STR40##M. Coloring AgentsPhenols and NaphtholsAminophenol2-NaphtholD&C Green No. 8 ##STR41##Hydroxy azo derivativesD&C Red No. 9D&C Orange No. 4 ##STR42##N. Fragrances/FlavorsPhenolsMenthyl SalicylateThymolVanillin ##STR43##______________________________________ Any compatible antimicrobial agent of the kind presently employed in cream/ointment formulations may be used in the topical antimicrobial composition of the invention. Suitable agents may possess antiviral, antibacterial and other activities. Preferred antimicrobial agents include those which have been shown to be effective against the HIV virus such as Nonoxynol-9 (nonylphenoxypolyethoxyethanol) and AZT (azidothymidine, or zidovudine). Nonoxynol-9 has also become well recognized as an effective virucide and of assistance in killing the AIDS virus. The U.S. surgeon general has urged the public to utilize condoms in combination with nonoxynol-9 to fight AIDS. Clinical 327 pg. 12, Nov. 23, 1983 FDA Regulation. Vaginal foam:12.5% nonoxynol-9 to vaginal jelly 2%. Effective for up to 24 hours for sponge at 1 g nonoxynol-9. Other useful antimicrobials include chlorhexidene, hexachlorophene (i.e. 0.5 to 4 w/v %), iodine (i.e. about 2 to 10% solution in water), sodium oxychlorosene (i.e. a complex of the sodium salt of dodecylbenzene-sulfonic acid and hypochlorous acid at about 0.1 to 0.4% solution in water), tetrachlorosalicylanilide (2% IMPREGNON), silver sulfadiazine (i.e. SSD-1%), butaconazole nitrate (i.e. 2%), chloroxylenol, and fungicidal agents such as triacetin (i.e. TINCTURE) and aluminum chlorhydrate. A preferred antimicrobial agent for this invention is Nonoxynol-9, because this agent has proven safe and effective for human use. Sunscreening agents which may be used include aminobenzoates, benzophenones, and cinnamates (i.e. about 8%). Other topical bioactive agents within the scope of the present invention include various AIDS related complex therapeutic agents, analgesics (i.e. acetaminophen), macrolides, about 2% erythromycin, parenterals (i.e. Polymyxin B-Bacltracin), sulfonamides, salicylates (i.e. triethanolamine salicylate 10%), topical analgesic, local and topical anesthetics (i.e. benzocaine 20%), glycolic acid (i.e. 5% to 10%), anorectal products (i.e. creams, foams, lotions, ointments (i.e. NUPERCAINAL)) and other materials such as aerosol sprays (i.e. HURRICANE topical anesthetic aerosol spray (20% Benzocaine) (Beutilich)), anthelmintics (i.e. permethrin 1 to 5%), antiarthritics (i.e. flurbiprofen), antibiotics (i.e. 2% mupirocin), active ingredients for herpes treatment such as those in Nerpacin-L Cold Sore Lip Balm (Campbell), Zovirax Ointment 5% (i.e. Acyclovir-9 2-hydroxyethoxylmethly)quanine! (Burroughs Wellcome), active ingredients for insect bites and stings such as those in Dermalde Aloe Cream (i.e. Aloe vera Jel) (Dermaide Research), Dermoplast Anesthetic Pain Relief Lotion and Spray (i.e. Benzocaine 8% and menthol 0.5%) (Whitehall), moisturizers (i.e. 10% urea), photosensitizers (i.e. 1% methoxsalen) such as those in Oxsoralen lotion 1% (ICN Pharmaceuticals), pruritus medications (i.e. about 0.06% fluoccinonide), psoriasis agents, scabicides (i.e. 1% lindane), seborrhea treatment (i.e. 0.5% coal tar, 2% salicyclic acid, 2% sulfur), antihistamines (i.e. Benadryl cream, 2% diphenhydramine), anti-inflammatory agents (i.e. about 0.5% alclometasone dipropionate), sulfonamides, cleansing agents (i.e. 7.5 to 10% povidone-indine), coal tar, dandruff medications, deodorants (i.e. aluminum chloride (hexahydrate) 20% w/v), dermatitis relief agents (i.e. nystatin-triamcinolone acetonide), detergents (i.e. Betadine Skin Cleanser containing povidone-iodine 7.5%), drying agents (i.e. Formaldehyde-10%), emollients, epidermal and cellular growth agents (i.e. vitamins A and E), fungicides (i.e. nystatin and triamcinolone acetonide), antiseptics (i.e. about 2 to 3.2% glutaraldehyde, about 0.25 to 5% sodium hypochlorite, thimerosal, about 0.25% triclosan, about 0.2 to 3% hexachlorophene, chlorhexidine gluconate, benzalkonium chloride), antiparasitics (i.e. lindane, the active ingredient in KWELL at 1%), antiglaucomatous agents (i.e. betaxolol HCl, C.sub.18 H.sub.29 NO.sub.3 HCl, the active ingredient in BEPTOPTIC, at 0.25% of base suspension), bee sting relief agents (i.e. benzocaine 8% and menthol 0.5%), disinfectants, sanitizers, germicides, bactericides, antiviral agents, algaecides, preservatives, chlorine compounds, iodine compounds, phenols, bisphenols, salicyanilides, carbanilides, amphoteric surfactants, mercurials, silver compound, etc. as listed in Physicians Desk Reference published by Medical Economics Data, 1992 edition and by publications of the EPA. The concentration of antimicrobial/biocidal agent and other topical bioactive agents in the present invention will depend on the strength, for example, of the antimicrobial required. For example, usually only a small amount of the antimicrobial compound is needed. The addition of as little as 0.1% by weight of one or more of the topical bioactive agents including the antimicrobial agent will usually provide a measurable increase in protection. A range of 0.1 to 15 wt. % is preferred for the topical bioactive agent of the invention. With respect to the antimicrobial agent, excess amounts of the antimicrobial compound ordinarily do not provide further improvement in the properties of the surface-coating compositions and reduce the effectiveness of the skin barrier. The precise amount of the topical bioactive agents such as the antimicrobial compound that will provide optimum protection for a given composition will depend on such factors as the activity of the particular topical compound employed, its toxicity, the propensity of the compound to cause irritation, the duration of use contemplated, the choice of materials which make up the cream base, and the application for which the coating compound is intended. Accordingly, the amount of the topical bioactive agent may vary widely, and combinations of several agents having different activities may be desirable. The topical bioactive agent is preferably dispersed in an oil-in-water (o/w) emulsion base comprised of an alkali metal fatty acid salt such as sodium palmirate or sodium taurate, an alkalimetal silicate such as sodium or potassium silicate, in water. The water soluble salts of fatty acids, derived from alkaline hydrolysis (saponification) of plant or animal fats and oils which are widely used in cosmetic products, are used in the invention to provide water-repellency. Alkali-metal salts of saturated or unsaturated fatty acids having from 8 to 18 carbon atoms are preferred. These include, by way of illustration only, sodium caprylate (C6), sodium laurate (C10), sodium myristate (C12), sodium palmirate (C14), sodium oleate (C16, 1 double bond), and sodium stearate (C16). The alkali metal salt of a fatty acid is generally one which is solid at room temperature so that it forms a solid film on the skin in combination with the silicate. The fatty acid salt component comprises between 15 and 40 wt. %, especially between 20-30 wt. % of the surface coating composition. An alkali-metal silicate is added to the composition in an amount effective to reduce the tackiness of the fatty acid component and to enhance the effectiveness of the topical barrier. The amount of alkali metal silicate added is between about 0.5 to 8 wt. %, preferably from about 0.5 to 3 wt. %. The alkali-metal silicate may be sodium silicate (Na.sub.4 SiO.sub.4), potassium silicate, or may comprise a siloxane oligomer or polymer such as polydimethylsiloxane, or salt thereof, having equivalent characteristics. The composition of the invention should have a viscosity suitable for topical application. A polyol may be added no achieve and maintain the proper viscosity, as well as to prevent excessive drying and cracking of the surface film. Polyols such as glycerin also act as emollients. Preferred polyols include glycerin, sorbitol and propylene glycol. The polyol is preferably used in an amount of 5 to 20 wt. % of the composition. The composition of the invention may further contain other additives such as pigments, emulsifiers, supplemental biocides, and the like. The composition of the invention may be used in a variety of applications. One embodiment of the product is in response to the need for secondary topical barriers that will help protect health care workers (i.e., nurses, doctors, technicians), public servants (i.e., E.M.T.'s, police, fire personnel), home health care providers, family members, or anyone needing protection from infectious contact with another person's bodily fluids. Thousands of people, ordinarily through occupational choice, must face contact with such infectious fluids, some of which carry fatal infections (i.e., the HIV or AIDS virus). The lethal quality of this infection has justifiably created significant concern and apprehension among all those involved in health care and has manifested itself in two ways. First, greater numbers of people are choosing not to pursue or continue careers that place them at risk. Fewer employees results in correspondingly poorer quality and quantity of health care and public service for both infected and non-infected persons. Second, the possibility of AIDS has created a perception that all those being treated have a potentially fatal infection unless proven otherwise. For health care applications, the composition of the invention both coats the skin with a protective barrier that inhibits infection from entering the body through the skin, and kills infectious organism/viruses before they enter the body. The composition also coats and seals wounds with a protective barrier so as to prevent infection. Use of the composition in accordance with the method of the invention should provide a means of reducing the overall risk of infection and promote a more secure, less apprehensive attitude towards both infected and non-infected persons in health care workers. An unexpected quality of the preferred composition of the invention, the skin cream described above, as is its propensity to coat small cuts, abrasions, or sores with a somewhat thicker layer of barrier, thus making the most accessible areas for infection the most protected. Bodily fluids of another coming in contact with the barrier tend to release the antimicrobial agent, e.g., nonylphenoxypolyethoxyethanol, allowing it to destroy infectious organisms such as HIV. The skin film/coating allows the health care worker to apply a secondary barrier to skin, particularly in areas of the body which cannot be gloved or clothed, such as the face. This coating further provides a secondary barrier when applied to areas of the body where clothing or gowns or gloves suffer failure or saturation, such as the chest, abdomen, upper arms, face and hands, the outcome being a less infectious health care environment. In light of the foregoing, a method of protecting a person working in proximity to bodily fluids such as blood or urine from infection from such fluids includes the initial step of applying to the skin of such a worker a protective composition consisting essentially of an aqueous base composition as described above and the antimicrobial agent. The base composition dries in a short time to form a film on the skin effective as a topical barrier against bodily fluids, i.e., that substantially prevents the contaminating fluids from reaching the skin. In addition, the film contains the antimicrobial agent in an amount effective to kill one or more types of infectious organisms, and can be removed with soap and water. The health care worker wears the film while performing a task such as a surgical operation or medical procedure in close proximity to a patient which may be the source of infected bodily fluids, particularly HIV infected blood. Some surgical operations or procedures, such as open heart surgery, routinely involve contact between the blood of the patient and the physician. Incidental contact between the doctor and the patient's blood is nearly unavoidable in such situations, and in this context the method of the invention is particularly valuable. The surgeon, nurse, technician or other medical worker normally puts on protective garments such as scrub suit, surgical gloves, mask and the like. Such garments can be worn over skin to which the protective composition has been applied to provide additional protection. The protective composition may also be applied to areas of skin to which not covered by protective garments, such as the face and neck. The protective film is removed from the worker's skin upon completion of the task. For this purpose, the film of the invention must be readily removable, preferably by washing it from the skin with soap and water, to remove any residual contamination. For this purpose, the protective composition is preferably the cream discussed above consisting essentially of 15 to 40 wt. % of the alkali-metal fatty acid salt having from 8 to 18 carbon atoms, an effective amount of the antimicrobial compound, 5 to 20 wt. % of a polyol effective as an emollient, 0.5 to 8.0 wt. %, of an alkali metal silicate, and the balance water. However, other compositions comprising a removable film-forming base and an antimicrobial agent can be used. After the medical operation, procedure, or other comparable task is done and the film has been removed, the method of the invention can be repeated during the same day, or even immediately. This permits the health care worker to perform one or more additional medical operations or procedures without risk of contaminating one patient with infection from another due to residual film on the skin. Antimicrobial skin compositions according to the prior designed for long term use are generally not suitable for this purpose. Other uses for the composition of the invention also exist. The base composition, without the antimicrobial component, can be used in industry to protect portions of surface areas from finishing processes or unwanted dyes, inks or paints. Surfaces adjacent to those which are to be finished could be coated with the surface coating composition to form a temporary barrier from the finishing substance. This protective barrier could easily be removed with water after the finishing process was completed. The base composition can also be applied to metal surfaces, such as silver, to protect such surfaces from tarnishing. The present cream may be used not only as a barrier but as an identifier or marker for the presence of infectious bodily fluid (i.e. blood). In some instances, it would be to a worker's advantage to be aware than small, often unnoticed or microscopic amounts of blood have, in fact, contacted their skin. This blood, or bodily fluid, if overlooked could present significant opportunity for infection. If identified as present, this blood or bodily fluid can be dealt with, thus reducing the opportunity of infection. To this objective 1% to 5% wt. tincTune of Guaiacum, Aloin, Phenolphthalin, Benzidine, or other chemicals used to detect blood (see Gaensslen Sourcebook in Forensic Serology Immunology, Nat. Inst. of Justice, pp. 101-116 (1983)) can be added to the cream. This creates an immediate change in the color of the cream in the area where a bodily fluid such as blood comes in contact with the cream containing the TincTune of Guaiacum. TincTune of Guaiacum/Guepc is a well known detector of blood used at crime scenes by forensic scientists. The present cream may be packaged as an aerosol dispensed gel thus allowing for efficient, non-wasteful application of the product. The cream may be packaged as an aerosol gel by combining approximately 85% cream (concentrate) and 15% propellant (i.e. propane/butane mixture, propane/isobutane mixture, fluorocarbon propellants, or singularly isobutane) using the appropriate "pressure filling" Technology (as described in Cosmetics Science and Technology, Edition II, Volume 2, pages 468-470 by Balsam). The same viscous characteristics of the cream make packaging this product as an aerosol gel particularly easy as they need not be cooled to a liquid state prior to insertion in the appropriate container (see "Cold Filling Techniques" Cosmetics Science and Technology as above). Pressurized creams/gels also offer the positive property of stabilizing the composition to the extent that a uniform increase in viscosity becomes apparent. This offers the user an increased capability to accurately meter efficient amounts of the cream thus avoiding waste. One of the most common practiced microencapsulation in the pharmaceutical industry is to form slow-release oral dosage forms of lipophilic water-insoluble drugs. In general, water-insoluble drugs possess inherent slow-release properties, but in many cases their release rate can be increased by formulation of water-soluble drug-cyclodextrin inclusion complexes. Micro-encapsulation of such water-soluble complexes will result in drug-delivery forms with release rates independent of their water solubility. Loftsson et al., ACS Symposium Series, V520, pp. 168-189, 1993. The topical bioactive agents of the invention may be microencapsulated by these known techniques. Microencapsulated compounds (i.e. the topical bioactive agents) may be added to the cream to react or function in specific ways in specific biological or chemical environments. This cream can also contain a series of micro-encapsulated compounds that serve specific functions. In these cases the cream functions not only as a barrier but as a means of delivering a specific material which has been microencapsulated and added to the cream. The cream maintains its barrier properties but also becomes a matrix or vehicle containing a bioerodible delivery device for the sustained administration of a pro-determined dosage of a drug, antimicrobial, fungicide, antiviral, antiseptic, antiflamitory, antiparasitic, insecticide, catalytic testing compounds or other compound. The encapsulation may consist of a matrix of polyvalent cation crosslinked anionic polyelectrolyte material designed to bioerode in the presence of specific chemicals or biologic environments or substances such as blood, or other bodily fluids, chemicals or specific chemical properties such as pH, conductivity, surfactant action or other chemical processes. The presence of the aforementioned substances or conditions causes the microcapsule to bioerode, releasing the internal compounds to function as designed. A drug delivery preparation with controlled release time and rate, comprising a therapeutic agent being encapsulated in or coated by a solvent membrane may be used (i.e. U.S. Pat. No. 3,965,255). The process of microencapsulation per se is well known in the art (i.e. U.S. Pat. Nos. 3,962,414 and 5,517,982). The phrase "consisting essentially of" as used herein covers combinations with some additional elements but excludes additional unspecified ingredients which would affect the basic and novel characteristics of the product defined in the balance of the claim. In other words, the phrase "consisting essentially of" excludes ingredients that would materially affect the basic and novel characteristics of the claimed composition. The phrase "consisting essentially of" does not exclude the addition of another ingredient which does not materially affect the characteristics of the invention. The topical barrier creams of the invention are formulated and prepared by mixing alkali metal silicate (i.e. sodium silicate solution or sodium metasilicate) with a polyol effective as an emollient, such as glycerol, an alkali-metal fatty acid salt having from 8 to 18 carbon atoms, such as sodium laurate, water (i.e. distilled water) and a topical bioactive agent such as an antimicrobial. The mixture is then heated to 70 until the mixture changes to a semi-viscous liquid. The following non-limiting examples illustrate the invention: An antimicrobial cream having the following composition of ingredients is prepared: Nonoxynol-9 4 wt. % Sodium laurate 25 wt. % Sodium silicate 1 wt. % Glycerin 14 wt. % Purified water Balance These ingredients are heated to approximately 70 until cool. The resulting cream is then stored in a tube or other conventional container for later use. The foregoing composition is applied to a small open wound and observed to collect there, effectively filling in the wound. This additional protection for open wounds or sores, in combination with the low toxicity of the cream, is particularly effective for purposes of the invention. This Example shows that the preparation of the invention will function as a barrier to the passage of infectious agents and perhaps toxic or irritating substances. The following composition is used: Sodium laurate 25 wt. % Sodium silicate 1 wt. Glycerin 14 wt. % Purified water Balance Radiolabeled Virus--Vero (African Green Monkey Kidney) cells, grown using standard procedures, are used for preparation of labeled viral stocks. The cells are infected with HSV-1 strain KOS at a multiplicity of 2 pfu/cell. Five hours post-infection .sup.3 5!-methionine is added to the media (40 μCi/ml final concentration) and the cells are incubated at 37 C. When 90-100% of the cells show evidence of infection, they are scraped from the plate and collected by centrifugation at 500 xg for 10 minutes. Radiolabeled virions are then isolated as described by Visalli et al., Virus Res 29, 167-178 (1993). Briefly, the cells, suspended in RSB buffer, are frozen and thawed 3 times to release virus and centrifuged at 500 xg for 10 minutes to remove the debris. The supernatant containing virus is layered on a cushion of 36% sucrose in RSB and centrifuged at 13,000 rpm for 80 minutes in a Beckman SW28 rotor to pellet the virions. The pellet is resuspended in RSB and the cushion centrifugation step is repeated. The pellet is resuspended in RSB and the radioactivity determined. Barrier Assay--A modification of the method of Oz et al., Infect Cont Hosoital Epidem 12, 93-95 (1991). Briefly, Whatman filter paper (qualitative #2) is cut into small sections. One filter section is coated with the cream and a second control filter paper section is wetted and blotted to dampness. The filter containing the cream is weighed to determine the amount of cream used. Both filter papers are placed on dry filter paper sections to form 2 layers. The radiolabeled virus suspension (100 μl, 5 paper and at various times (0, 5, 15, 30, 60, and 180 minutes) the top filters are removed. The bottom filters are then placed in scintillation fluid (Redisolve HP, Beckman Instruments) and the amount of label passing through the top filters determined in a Beckman LS2801 scintillation counter. All samples are done in duplicate and average values are reported. Weighing of the filters before and after application of the cream reveal an average of 0.12.+-04 g of cream. Radiolabeled virus passes immediately through the control filter (FIG. 2). Saturation (approximately 7,000 cpm per filter) is reached as soon as we could measure the transfer. In contrast, the cream reduced the rate of transfer of radiolabeled virus. At time 0, only 29 cpm transfers to the bottom filter. Increasing amounts of label transferred through the barrier, but saturation is not reached until 60 minutes. Transfer through the cream occurs with first order kinetics. When the control values are set at 100% (FIG. 1) and the data is plotted as a percent of the control, only 0.4% of the virus had passed through at time 0. At 5 minutes, only 4.5% had passed and this increased slowly until 60' when 96.5% had transferred. These results demonstrate that the cream has barrier activity. The presence of the cream delays passage of the label by up to 60 minutes. The differences at times up to 30 minutes are significantly different, indicating a substantial barrier effect is obtained. These results compare favorably with those of others (e.g., Oz et al., Infect Cont Hospital Epidem 12, 93-95 (1991)) who use a lanolin-based gel. Nine anti-bacterial solutions are formulated which contain either aqueous sodium metasilicate or sodium silicate solution. The first five solutions are prepared by varying sodium metasilicate from 1-5 weight percent. The final four are prepared with the sodium silicate solution in weight percents of 1.8, 3.6, 5, and 9.5. In addition to these silicate compounds, each solution contain glycerol (14 wt. %), sodium laurate (25%), Nonoxynol-9 (4%), and the remainder Milli-Q distilled water. The initial mixture is a white, fluffy powder that contains about 80% sodium laurate by volume. The mixture is heated to 70 a clear, viscous liquid. After cooling to room temperature, the end product is a, white semiviscous cream. The pH of the products are about 10. The nine solutions are changed by varying the weight percent of the two silicate compounds. Table 2 shows the actual component weights and weight percents for the first set of runs. Weights and weight percents for the second set of runs are shown in Table 3. TABLE 2__________________________________________________________________________Sodium Metasilicate Solution Data Trial 1 Trial 2 Trial 3 Trial 4 Trial 5 (solution SP-1) (solution SP-2) (solution SP-3) (solution SP-4) (solution SP-5)Component Mass (g) Weight % Mass (g) Weight % Mass (g) Weight % Mass (g) Weight % Mass Weight__________________________________________________________________________ %sodium laurate 7.50 24.93 7.50 24.83 7.50 24.79 7.49 24.86 7.50 24.93sodium metasilicate *5H20 0.52 1.73 1.03 3.41 1.56 5.16 2.09 6.94 2.63 8.74glycerol 4.24 14.10 4.19 13.87 4.22 13.95 4.21 13.97 4.21 13.99Nonoxynol-9 1.22 4.06 1.29 4.27 1.23 4.06 1.24 4.12 1.26 4.19Milli-Q 16.60 55.19 16.20 53.62 15.75 52.05 15.10 50.12 14.49 48.16Total 30.08 100.00 30.21 100.00 30.26 100.00 30.13 100.00 30.09 100.00__________________________________________________________________________ TABLE 3__________________________________________________________________________Sodium Silicate Solution Data Trial 1 Trial 2 Trial 3 Trial 4 (solution SS-1) (solution SS-2) (solution SS-3) (solution SS-4)Component Mass (g) Weight % Mass (g) Weight % Mass (g) Weight % Mass (g) Weight %__________________________________________________________________________sodium laurate 7.50 24.93 7.49 24.79 7.53 24.88 7.51 24.93sodium silicate solution 0.55 1.83 1.08 3.57 1.51 4.99 2.84 9.43glycerol 4.18 13.90 4.22 13.97 4.24 14.01 4.19 13.91Nonoxynol-9 1.19 3.96 1.19 3.94 1.29 4.26 1.21 4.02Milli-Q 16.57 55.09 16.25 53.79 15.47 51.12 14.23 47.23Total 29.99 100.00 30.23 100.00 30.04 100.00 29.98 100.00__________________________________________________________________________ The system analyzed is classified into one of four categories which includes: suspensions, emulsions, lotions, and ointments. Suspensions: Dispersions of solid particles in a liquid continuous phase with or without the aid of a suspending agent. It may be used for oral or external use. Emulsions: Dispersion of two immiscible liquids. One liquid is dispersed as small globules in the other liquid with the aid of an emulsifying agent. Lotions: Liquids that are intended for topical or external application to the skin. In some cases, they contain suspended solid particles. *Ointments: Semi-solid preparations intended for application to the skin. They may consist of oleaginous substances, may be free from oleaginous substances, and/or be classified as emulsions. The next step is to analyze each component for its potential hazards, general uses, physical properties, and related names. Shown below is a summary for each of the components, excluding distilled water. Sodium Metasilicate In general, the use of silicates in coatings and adhesives in contact with foods and small amounts of liquid silicates are accepted by the FDA and are regularly used to prevent corrosion in canned drinking water. On the other hand, silicates need to be handled properly due to their moderately to strongly alkaline pH (pH 10-12) and buffering properties. As a result of the basic nature of sodium silicate, many applications have been recognized including: detergents, "builders" for bar soaps, films, coatings, and concrete treatment. In detergents the sodium silicate acts as a deflocullator (breaking particulate particles into fine particles which stay suspended in solution) and a buffer (resisting pH changes). Also, an important property of sodium silicate, shown in concrete treatment, is the ability to act as a sealant. Thus, it forms an insoluble gel within the concrete pores providing protection from water, oil, and acid. The physical properties of solid sodium metasilicate include: small off white solid particles, density of about 1.7 g/ml, melting point about 70 compound are Disodium Monosilicate and Metso beads 2048. Nonoxynol-9 This component is fairly harmless when weight percentages of 0 to about 15% are used in solution. For over 30 years nonoxynol-9 (i.e. N-9) has been used as a spermicide in many over the counter contraceptive products. Another important use is for protection against viruses. When used in spermicide at 5% concentrations, N-9 has the capability to inactivate many sexually transmitted pathogens primarily by their detergent affect on bacteria cell membranes and viral envelopes. Also, N-9 can be used between standard latex gloves to improve surgical glove safety compared with latex gloves alone with respect to needlestick transmission of the virus, HIV-1. The physical properties of N-9 include: light yellow to colorless liquid, density of about 1.06 g/ml, viscosity of about 175 to 250 cp., high water solubility. Another name for nonoxynol-9 is Triton N-101. Glycerol Since 1959 glycerol has been recognized and safe as a general food additive and has been safely tested intravenously in concentrations of less than 5%. Several uses for glycerol which include food additives (syrup), drugs, and cosmetics all incorporate the ability of glycerol as a solvent, a moistening agent, or a lubricant. For example, it is used in toothpaste to maintain the desired smoothness and viscosity. Also, glycerol is used in many creams and lotions to keep the skin soft and replace skin moisture. The physical properties of glycerol include: light brown liquid, density of about 1.47 g/ml, viscosity 1499 cp., melting point of about 18.2.degree. C., and high solubility in water and alcohol (not hydrocarbons). Glycerin, propane-1,2,3-triol are other synonyms for glycerol. Sodium Laurate This component is an extremely low dense white powder is soluble in water. The final step after defining the system and analyzing each component is to design suitable preparation criteria. The primary objectives for formulation are: any solid particles of the suspended drug should be of a relatively uniform size so they act uniformly, particle sizes should be such that in the case of topically applied suspension is not gritty when applied, and insure a minimum of aggregation and flocculation. The general method for compounding is shown below step by step. 1. Reduce large solid particles in a mortar. 2. Solids are wetted with aqueous components such as glycerin. 3. Once a smooth paste has been formed, bring to final volume with final aqueous components. 4. Heat to appropriate temperature at a constant rate until complete solubility is attained and let cool to final form. Finally, steps could be taken to increase or decrease the viscosity or "liquid" like property in the final prepared solution. Mainly glycerol or possibly water can be added to decrease the viscosity to more of a gelatin type product. If the product proves to be non-viscous, sodium laurate or silicate can be added. The procedure for preparing an ointment containing glycerol (14 wt %), sodium laurate (25%), Nonoxynol-9 (4%), sodium metasilicate (1%) and the remainder distilled water is as follows. Equipment Analytical balance Hot plate with magnetic stirrer Materials Glycerol (Aldrich, catalog #56-81-5, lot #12131KZ) Nonoxynol-9 (Aldrich, catalog #26027-38-3, lot #04510JX) Milli-Q distilled water Sodium laurate (Sigma, catalog #629-25-4, lot #62H5003) Sodium metasilicate pentahydrate (Sigma, cat. #10213-79-31, lot #92H2624) Sodium silicate solution (Aldrich, catalog #1344-09-8, lot #17703BZ) Preparation 1) Add 7.5 g of sodium laurate to a 100 ml beaker, followed by 0.52 g of sodium metasilicate, 4.2 g of glycerol, and 1.2 g of Nonoxynol-9. 2) Fill with distilled water until a total solution weight of 30 g is obtained. The solution level will drop so the walls of the beaker were rinsed while adding the distilled water. A white fluffy solid should result that fills approximately half the beaker (about 50 ml). 3) Heat solution up to 70 stirrer. The solution should turn to a clear, viscous liquid with a yellow tint. 4) Remove solution from the hot water bath and cool at room temperature. As the solution approaches room temperature, a white precipitate should be observed. Two anti-bacterial ointments are formulated with identical components except one contained sodium metasilicate (solution 1) and the other sodium silicate solution (solution 2). Solution 1 is prepared by varying the weight % of sodium metasilicate from 1-5% in increments of 1%. Solution 2 is prepared by using 1.8 wt %, 3.6%, 5%, and 9.5% of sodium silicate solution. Before the solutions are heated, both are a fluffy, white solid with sodium laurate occupying about 80% of the volume. Solution 1 has a greater volume because the sodium laurate is slightly dissolved. After heating, the solutions are a clear, viscous liquid with a yellow tint. Once the solutions are cooled to room temperature, a white solid forms that has properties similar to a bar of soap. Solution 1 solidifies from the top and bottom, while solution 2 precipitates from the top. Solution 1 solidifies faster than solution 2, approximately 15 minutes compared to 25 minutes. Trials SS-2 and SS-3 of solution 2 never fully solidify, so they are mixed by poking holes through the top layer with a stirring rod. A clear gel is found under the precipitate in SS-2 and a clear liquid found under the SS-3 precipitate. After mixing, the two solutions are uniform with trial SS-2 softer than the other trials. This example evaluates (i) the in vitro effectiveness of the formulation as a barrier to the passage of virus, and (ii) determines if the formulation has a direct virucidal effect. The basic strategy for evaluating the barrier function of the formulation will be to coat a porous surface with the formulation, place a solution containing the virus on one side, and then measure the amount of virus that passes through the barrier. The function as a barrier may depend on cell/organism size. Therefore, a small mouse picornavirus called GDVII (27 nm diameter) and a relatively large virus HSV-1 (150 to 200 nm diameter) will be tested. The function of the barrier may depend on whether the virus has an envelope. The use of GDVII and HSV-1 will confirm this possibility since the former lacks an envelope and the latter is enveloped. Initial experiments use viruses radioactively labeled by known techniques and purified before use to remove interfering cellular debris. The radioactively labeled virus will provide a very sensitive assay for penetration. Although some radiolabeled virus may pass the barrier, this virus should be rendered non-infectious by an antimicrobial such as nonoxynol-9. Therefore the fluid on the opposite side of the barrier will be tested for infectious viruses using a plaque assay or serial dilution assay on appropriate cell lines. Nonoxynol-9 (1-3%) will also be used in the barrier in some tests to determine if the effectiveness can be increased. Vero cells, which are used for HSV-1, will be grown in DME with 5% serum as described previously (Grau et al., 1989; Brandt and Grau, Invest Ophthalmol Vis. Sci. 31, 2214-2223, 1990; Brandt et al., J. Virol. Meth. 35: 127-135, 1991; Visalli and Brandt, Virology 185: 419-423, 1991; Brandt et al., Ophthalmic Research, 1992. Mouse L-929 cells, for growth of GDVII virus, will be grown in the same media. High titer stocks of HSV-1 strain KOS will be grown as described in Grave et al., 1989. High titer stocks of GDVII virus will be grown as described in previously (Brandt and Salkowski, Invest. Ophthalmol Vis. Sci. 33: 113-120, 1992. Plaque assays will be carried out using 2% methocell overlay by conventional techniques. Virus will be radiolabeled using .sup.35 S!-methionine (40 μg/ml) as described previously (Visalli and Brandt, Virology, 185: 419-423, 1991; Viruses will be purified using sucrose gradients as described previously. To assay for barrier function, we will use double well plates (Falcon #3090, 3091, 3095, or 3096). These plates contain an insert with a porous membrane (0.45 or 3 μm) at the bottom. Membranes of both pore sizes will be used. The membrane on the insert will be coated with the barrier and inserted into the well of the culture plate. The well in the culture plate will contain media in contact with the underside of the membrane. The virus suspension (1 insert and at various times (0, 15', 30', 60', 3 hr, 6 hr, 24 hr, and 48 hr). The media in the well will be removed and then assay for the presence of radiolabeled virus by scintillation counting or infectious virus by plaque assay. To ascertain the effect of drying on the barrier, the barrier function will be tested immediately after application and after drying for 30 and 60 min prior to the addition of the virus. This or a modification of the method of Oz et al., Infect. Cont. Hospital Epidem. 12, 93-95 (1991), which is the method used for example 2, may be used. As a control to test whether the barrier is formed, a solution containing .sup.3 H-labeled water will be placed in the insert and penetration of the label will be measured. The use of .sup.3 H for this test will not interfere with the viral penetration assay since the viruses will be labeled with .sup.35 S!-methionine. After determining that the barrier was established, the .sup.3 H solution will be removed and the virus suspension will be added. The formulation will be applied to the membrane of the insert using a cotton or dacron tipped swab. In order to evaluate virucidal activity, the barrier cream, with or without nonoxynol-9, will be applied to the bottom of a cell culture well (Falcon #3047 24 well plate). A solution of infectious virus will then be added and incubated at 37 surviving virus will be measured by plaque assay on appropriate cells. As a control, virus will be added to untreated tissue culture wells. Between 10.sup.3 and 10.sup.6 plaque forming units (pfu) will be used initially. If no effect is observed, 1 This example tests in vitro the barrier and antimicrobial activity of the cream. Previous examples showed the barrier effect of the cream per se. In this example, the properties of the antimicrobial will be assayed to eliminate the different viruses that are in contact with the cream. The formulation of the cream is as follows: Nonoxynol-9 4 wt. % Sodium laurate 25 wt. % Sodium silicate 1 wt. % Glycerin 14 wt. % Purified water Balance The amounts of antimicrobials is then varied. The first to be tested will be non-oxynonol-9 at a range of 0.01 to 15 wt %. The HSV (herpes simplex virus) viruses will be labeled and incubated. When 90-100% of the cells show evidence of infection they will be collected. The methods of growing and collection of the viruses will be the same as described in previous Examples. The FDA considers nonoxynol-9 to be safe and effective. Laboratory studies indicate that nonoxynol-9, a nonionic surfactant used as a spermicide, inactivates HIV and other sexually transmitted pathogens. Evidence from in vitro studies suggests that spermicides containing nonoxynol-9 may be effective in preventing the transmission of HIV (Lancet March 19, p. 654, 1987). In assay studies, formulations containing amounts of the spermicide was found to inactivate HIV at concentrations of between 0.1 to 1.0% and nonoxynol-9 alone was active at 0.05%. Using the methods of the previous Examples the cream with nonoxynol-9 at levels from 0.1 to 15% wt will be tested. Briefly white filter paper is cut into small sections. One filter section coated with the cream and a second control filter paper is wetted and blotted to dampness. Cream will be weighed, and both filter papers placed on dry filter paper sections to form 2 layers. The virus (radiolabled) placed on top of filters. The bottom filters will then be placed in scintillation fluid and the amount of label passing through the top filter determined in a scintillation counter. Studies to determine the efficacy of the antimicrobial compound have used rabbit models. At this point, the eyes of the rabbits will be infected to detect if the HSV virus, the leading cause of blindness due to infectious diseases in developed countries, will cloud the eye if still active. Another method is a new murine model of herpes simplex virus-induced ocular disease for antiviral drug testing (Brandt, et al. Journal of Virological Methods, 36 (1992)). Other active ingredients can be similarly tested. Such active ingredients include: Fungicides, soaps, antibiotics, antiviral, anti-infectives, insect repellents and athletes foot medications. Microencapsulating of all of the above will be performed by known techniques described previously. Aerosol applications and adding color by known methods for alerting the wearer to the presence of bodily fluids will be performed. It will be understood that the foregoing description is of preferred exemplary embodiments of the invention, and than the invention is not limited to the specific forms shown. Modifications may be made in the design and arrangement of the elements without departing from the scope of the invention as expressed in the appended claims. Patent Citations
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Genre/Form: | Feature films Interviews Biography |
Named Person: | Vincent Price; Vincent Price |
Material Type: | Videorecording, Internet resource |
Document Type: | Internet Resource, Computer File, Visual material |
All Authors / Contributors: |
Vincent Price; Stanley J Sheff; David Del Valle; Image Entertainment (Firm); OverDrive, Inc. |
OCLC Number: | 77059194 |
Notes: | Downloadable video file. Title from title screen (viewed Dec. 18, 2006). |
Performer(s): | Vincent Price, host, David Del Valle. |
Target Audience: | Rating: Not rated. |
Details: | Mode of access: World Wide Web.; System requirements: OverDrive Media Console (file size: 326988KB). |
Responsibility: | [directed by] Stanley Sheff. |
Vincent Price is one of the most beloved stars Hollywood ever saw. His extraordinary career spanned over five decades, and covered every media: film, television, radio, theater.
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DescriptionThe Trundler's Club Buttress is a Gothic looking complex of stone, which is dominated by large systems, and steep head walls. Two routes punch up this airy, and intimidating 350' chunk of stone: Getting ThereFollow directions for the Religion wall past the watchtower. Stick close to the wall and you will encounter some fixed approach lines. Climb up to the limestone band and follow it around to the east between Minister and the Pulpit and the main wall. Once through the notch stick to the main wall and look for faint trail. A hairy move on the limestone band and some scrambling will put you at the base. Approach time- 45 min... It's pumpy. 2 Total Routes
The ClassicsMountain Project's determination of some of the classic, most popular, highest rated routes for Trundler's Club Buttress:
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Pussy Mind Trick (PMT) 5.12- 7a+ 25 VIII+ E5 6a AZ : Sedona Area : ... : Trundler's Club Buttress
PMT takes a proud line of resistance up the steep front of the buttress. Expect technical face climbing, as well as, down home crack slugging. The third pitch offers as much exposure as you can get on the formation, and is an unforgettable experience.To the right of Trundlers Club. Pitch 1, 5.12-, A stunning combination of features makes this line possible. Climb wistfully if you can through shallow dihedrals, small aretes, and thin, solid face holds past bolts to a two bolt, semi hang...[more] Browse More Classics in AZ
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Residence Inn Providence Warwick
Travel Blogs from Warwick
My Rubicon
... Steve and Julie (reminder: our captain and chef) had had enough and decided to leave on the spot. They packed their bags and off they went. Well, I cannot explain the mix of emotions I had then, and since then. As a yachtie, things took place after that which would NEVER happen in the yachting world, e.g. the owner's wife cooking dinner for her guests in the galley (crew area), the owner taking Andy and myself provisioning (he ...
Ferry to Martha's Vineyard
After all that baseball action it wasn't easy to get up and head for Woods Hole MA to make the ferry to Martha's Vineyard but we managed. How lucky we were to have a gorgeous day for this trip. We were also lucky enough to be on tour with what must be the ...
One Day Grand Tour of Newport
... Newport recreational treasure of public parks and miles of public access shoreline to rank as one of the most popular "drives" in the country.
Back on the subject of food... We had heard that the best place for lunch was a boutique sandwich shop called Rosemary & Thyme Artisan Bakery & Cafe. This small venue was too cramped and too ...
Welcome to Newport!
... out. Whose feet are they really? Some say Greta Garbo, Merle Haggard, Dorothy Lamore, Billy Carter, or Susan Lisella. It's a mystery whose answer is often sought by checking the size with socks. Throughout the year various socks, red, blue, plaid are mysteriously attached to the feet during cover of darkness.
Newport has one of the highest ...
The Road to Rhode Island
... between her tits and her tips, so she spent most of the night bounding about in a tanktop, sticking bottles of whiskey down her top and putting a straw in her cleavage and blowing. I'm sure her house is ******* massive off the back of this.� It was pretty quiet but everyone had congregated round the bar, for some reason, so we were relegated to a booth to watch Catching Hell, a baseball documentary about Bartman, some hapless ******* who went to catch a foul ...
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By Lisa Johnston
New products on display at the American International Toy Fair, held in N
As a native New Yorker and someone who has covered the CE industry for more than a few years, I don't know if I am appalled or bemused about a story that appeared in Monday's Philadelphia Inquirer and was picked up today by CNN: The Apple Store on Fifth Avenue and East 58th Street is one of the five most-photographed landmarks in the Big Apple.
And, according to the item CNN ran this morning, it is the 28th most-photographed landmark in the world.
Here are New York City's five most-photographed landmarks, according to the story:
1. Empire State Building
2. Times Square
3. Rockefeller Center
4. Grand Central Station
5. Fifth Avenue Apple Store
Where's the Chrysler Building? The Brooklyn Bridge? How about the Statue of Liberty? You know, the main branch of The New York Public Library down a few blocks on Fifth Avenue at 42nd Street can't be in the top five. Its content is sooooo analog. And let's not mention the New York Stock Exchange after the unpleasantness of the past two years, shall we?
The Fifth Avenue Apple Store has become the definition of a destination store.
While every store can't be located on Fifth Avenue and have distinctive architecture and store layout (not to mention "must have" products), the lesson that store provides is that your stores must be distinctive and unique in certain ways to draw store traffic.
And it wouldn't hurt if you had good selection, a well-trained staff and pretty good prices too.
This TWICE webinar, hosted by senior editor Alan Wolf, will take a look at what may be the hottest CE products at retail that will be sold during the all-important fourth quarter. Top technologies, market strategies and industry trends will be discussed with industry analysts and executives.


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(4 Recipes) Created by DESIGNER777
Recipes in this Collection
Incredible! 5.0/5
(1 rating)
I bought a "Cosmic Cookie" at Planet Organic and was curious about the NI. I googled it and found the recipe! These make a great snack and pack some serious nutritional punch! Submitted by AMBOURGE Carbs: 20.9g | Fat: 6.2g | Fiber: 2.2g | Protein: 2.1g | Calories: 133.7
Great for the fall holidays or just for a snack! Submitted by ANDREWMOM Carbs: 28.5g | Fat: 1.7g | Fiber: 1.4g | Protein: 2.8g | Calories: 131.6
Very Good 4.7/5
(3 ratings)
A treat for under 100 calories. I wanted a cookie that was a little healthier and easy to fix. You can make more healthy substitutions to suite your taste and health needs. Submitted by GERWYN Carbs: 15.9g | Fat: 3g | Fiber: 1.2g | Protein: 1.9g | Calories: 92.5
(no ratings)
The perfect side for any holiday BBQ without all the calories and fat of mac & cheese, baked beans and slaw! Submitted by CRE8IVITY Carbs: 15.5g | Fat: 3.9g | Fiber: 3g | Protein: 2.7g | Calories: 97.4
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text:
Check out this versatile and deliciously rich Shrimp Paste. Quick and simple to make, serve and delight in this Shrimp Paste whichever way you please! - 27.3537
If you want to cut down on canned and preserved food in your cooking, start with garlic paste. This video shows how to make Homemade Garlic Paste very easily. So whether it is a curry or a vegetable that you need to sauté, trust this freshly made garlic... - 127.506
1. Heat a cast-iron skillet over medium heat. When it is hot, add the garlic and stir continuously until slightly golden and toasty, about 1 minute. Add the cardamom, cinnamon, cumin, coriander, and turmeric and stir for a few seconds or until the mixture is... - 29.581
Learn how to make Ginger Garlic paste at home which is easy to make and so much better than store bought pastes which are laden with unwanted chemicals. This paste can last in the fridge easily for 2-3 weeks. If you make larger batch, you can store small... - 0
This video is a creation of SuperVeggieDelight. You can visit SuperVeggieDelight for complete recipes, and more videos. - 82.9263
This homemade green curry paste is not meant for the weak hearted! It sure has tonnes more flavor than shop-bought versions but beware, it is spicy enough to bring beads of sweat burst on your forehead and smoke steam out of your ears! However if you are a... - 94.3469
If you're looking for the recipe of Hot Chili Paste then this is it. The Chef shows how to make this easy Hot Chili Paste at home. The paste can be used while making any dish. This is really hot and amazing. - 108.998
Want to replicate Curry Simple brand of Thai sauces? Chef Tina has successfully replicated this dish from scratch and her family is totally in love with the homemade Thai green curry. This curry can be a delicious base for all your favorite meat or seafood.... - 84.7876
Learn how to make Tahini Sauce from scratch a simple easy to follow recipe video. This is a great way to make tahini at home and can save you a lot of money so you can make more wonderful Mediterranean, Middle Eastern and Arabic recipes at home. So if you... - 111.945
Homemade Noodle Paste helps me prepare tastier noodle dishes. Follow this extremely easy noodle paste recipe and make your own noodles. This Noodle paste can also be used for dumplings and huntuns. - 31.4806
Beat the first 9 ingredients together until fluffy; then stir in sifted dry ingredients. Break off small pieces of the dough, and roll around each cherry to cover completely. Roll again to form small balls. Arrange 1 1/2 inches apart on an ungreased cookie... - 39.4114
Sift together flour and salt. Cut in 2 tablespoons butter with pastry blender. Sprinkle with a little ice water, adding it gradually and mixing in lightly with fork. Continue sprinkling and mixing in ice water until 1 1/4 cups have been added. If dough is... - 34.5839
Bring butter or margarine and water to boil in saucepan. Add flour and salt all at once. Beat vigorously over low heat until mixture leaves side of pan and forms a ball. Remove from heat; beat in 1 whole egg at a time, and after each addition beat until... - 35.6285
If you are looking to prepare pumpkin bread, pie, waffles and soups sans investing on store-bought pumpkin puree, here's what you need. Chef Todd Mohr, who believes in making cooking innovative and exciting, shares a simple way to puree pumpkin in a snap. So... - 84.9197
Put the lime juice, oil, kelp, and water in the container of an electric blender or food processor and blend or process at medium speed, while adding the ground sesame seeds. Continue blending or processing until the mixture is like thick heavy cream. - 20.8882
Learn how to make homemade apple puree for infants without any added flavors or preservatives. Perfect for weaning, apple is nutritious for your baby. Feeding baby apple puree is a great introduction to solid food. Enjoy this apple puree recipe. - 104.573
The can is there, there's a pumpkin on the label... open it and mix it up with spices to make a pie, right? A pumpkin pie made from a fresh pumpkin tastes so much better than the glop that was processed several months back! And it is much easier than you... - 136.831
1. Remove frozen livers from boxes but do not remove from pouches. Place in 2-quart microwave-safe casserole. Microwave, uncovered, at 50% power 5 minutes, turning pouches over once during cooking. Let stand 5 minutes. Remove livers from pouches and place in... - 37.2774
Melt the first 1/4 cup butter in a frying pan. Add the onions and saute over medium heat 3 minutes. Add the apples and continue cooking until the apples and onions are transparent. Pour into the container of a blender. Melt the second 1/4 cup butter, letting... - 46.2082
If you are a pizza fan and like making your own pizzas at home, having a large bottle of ready-to-use pizza sauce in your refrigerator is a must. This recipe is a fast and tasty base for whatever wonderfully creative toppings you decide to put on your pizza... - 107.255
Paneer Makhani or Buteer Paneer is a rich and delicious North Indian dish. Here's an easy way of making it with fresh, home made Tomato Puree which gives makhani awesome texture and smoothness. It goes well with Naan, Roti, Garlic Naan, Chapati or Rice. - 0
MAKING 1. In blender put canned tomatoes. Pulse or about 20-30 second to make it saucy. 2. Place a sauce pan over medium heat, pour oil, and sauté onion, and garlic in it for 5 minutes or until soften. 3. Add tomato paste and stir it well. Cook for 1... - 103.865
The drunk cook shows one of the many ways to make a hamburger! Easy and flavorful if not anything else in the video! The only problem would be the directions used are highly unhygienic and non appropriate by all means. - 67.038
This Sloppy Joes recipe is one that you would want to make over and over again. Ground meat simmered in an intensely flavored sauce and served with homemade burger buns is an incredible hit everytime. This comfort food is real quick and easy to make. - 34.6021
Check out this versatile and deliciously rich Sardine Appeteaser. Quick and simple to make, serve and delight in this Sardine Appeteaser whichever way you please! - 36.0344
Combine all ingredients in the bowl of a food processor fitted with a steel blade. Process until smooth, then stir in additional capers to taste. - 24.0491
This Cream Cheese-Anchovy Spread is very versatile. Also, this Cream Cheese-Anchovy Spread can be whipped up in just a few minutes. And now when it comes to serving, it goes perfect as a dip, an appetizer or the most apt being served as a spread! - 31.2665
Probably this is the most basic thing that everyone needs to learn – Pumpkin Puree. The Holidays are here, so you'll need to have this handy at all times. Watch and learn how to make this puree from this video! Enjoy! - 109.612
Italian Almond Kisses is an amazingly easy baked dessert which cannot just escape your guest's attention in any party. Try this delicious Italian Almond Kisses dish; I am sure you will get a huge fan following for this! - 38.9094
This Prince Phillip Cake is a mouthwatering baked dessert recipe. Enjoy this deadly cake recipe in your next weekend party! - 38.5168
I love mushrooms and this Mushroom Lover's Pate is one of my sweethearts. Not so spicy, not so hot the Mushroom Lover's Pate is quite an easy dish to prepare. Why don't you add this to your menu tonight? - 43.2627
Mock Marzipan is a very tempting snack recipe which you would love to serve to your dear ones. Enjoy this recipe prepared with the deadly combination of potatoes and almonds on the coming get together party! - 35.4853
Chicken Liver Pate is rich with the flavor of marinaded chicken. This chicken liver pate is not much spicy, however you can make it so, if need be. Try the chicken liver pate chilled or at room temperature. I love preparing this, hope you too will. - 46.8195
Whether you are entertaining Labor Day weekend or hosting a tailgate at home, homemade BBQ ribs makes for a great addition to your platter. Finger licking good, making "fall off the bone" tender BBQ ribs at home doesn't require cumbersome effort. IN... - 101.966
Those of you who like preparing paneer at home should check out this recipe. Chef Bhavna shows this simple recipe to make cottage cheese. In India we call it paneer. This is a quick recipe so if at all you can't buy paneer from the market then you can always... - 104.125
This recipe for homemade pasta is one I have refined over the past year and a half through trial and error. I love the results of this recipe and so will you! If you've never made handmade pasta, now's the time to start. Have fun in the kitchen! - 116.389
Watch as Chef/mom Ariane Duarte cooks one of DinnerTool's Slow Cooker Showdown contest finalist recipe submissions. - 119.786
Pick the rajmah, wash it in a number of changes of water and then leave it to soak in enough water to cover for at least 6-7 hours and overnight if possible. When you're ready to cook, first prepare all the ingredients. Peel the onions, chop them into... - 43.3877
A quick and easy spaghetti dish needs to be on your menu when you are looking for a super quick summertime delight. Discover how to make the perfect spaghetti with homemade meat sauce with a little help from Betty. It's so good and a little low on fats that... - 103.757
1. Wash the peas, soak overnight in water to cover. 2. Drain and add to the ham bone or pork in a large kettle. Add enough water to cover.Add onion and celery. Simmer until the peas are tender. 3. Force through a strainer. - 23.1897
Roll well-chilled dough to 1/4-inch thickness. Cut 3-inch rounds with cookie cutter. Remove 2-inch centers from 1/2 the rounds. Moisten edges of full rounds, and lightly press 1 ring shape on top of each. Place well apart on ungreased cookie sheet. Bake in... - 26.76
Melt drippings in a large heavy skillet. Add meat, and stir-fry until well colored. Drain off the fat. Scrape the meat into a deep saucepan. Add onions, green pepper, chili powder, salt, pepper, garlic powder and cayenne. Mix well. Then add kidney beans with... - 42.1358
Cream butter or margarine with almond paste; gradually beat in brown sugar and egg. Blend in flour. Pat in lightly buttered 13" x 9" x 2" pan. Bake in moderate oven, 325°F. 20 minutes. Spread with jam. Beat egg whites until frothy; gradually beat in sugar,... - 43.0889
Blend tomato paste with canned tomatoes; add pinch salt, and simmer 5 minutes. Meanwhile, wash, dry and slice eggplant crosswise into 1/2-inch slices; do not peel. Place in a bowl, cover with hot water and let stand 5 minutes. Drain slices, and pat dry with... - 42.0229
In a mixing bowl combine egg and milk. Stir in bread crumbs, onion, parsley, oregano, thyme, sage, 3/4 teaspoon salt, and 1/8 teaspoon pepper. Add veal and beef; mix well. Pat one fourth of the meat mixture into an 8x4x2 inch loaf pan. Arrange green beans... - 40.5604
I have in the past try to make homemake yogurt but unsuccessfully! Until, I discover the secrets or the KEY TIPS, which i am going to share with you here! Once you can make your own fresh yogurt, you can start to enjoy organic yogurt daily with numerous... - 33.2147
In blender container combine parsley, mayonnaise or salad dressing, sour cream, green onion, vinegar, anchovy paste, basil, and sugar. Cover and blend till smooth. Transfer to storage container. Cover and chill. - 29.7221
Deliciously sweet and amazingly gorgeous lemon sauce is truly a wonderful treat for the whole family. Yes my family is in love with this lemon sauce and I assure even yours will like it equally. Just give it a try and sit back and relish the taste. - 33.6571
This is an easy chili recipe that is so versatile that it's really up to you how you decide to serve it. You could serve it on its own, over burgers, nachos, baked potatoes...the possibilities are endless. It also can serve as a great make ahead meal. - 0
This Puff Paste is easily made with the help of oven or microwave. Try out this easy recipe and make your own homemade Puff Paste. - 38.8249
Have you always been buying expensive almond butter from the store? Well, then watch this video and learn to make the amazing butter at home, without any hassles. This is a very, very simple recipe and requires no cooking at all! Watch the video to know more.... - 112.205
In 3-quart casserole, combine oil, onion and garlic. Microwave at HIGH (10) 1 to 2 minutes. Add tomatoes, tomato paste, water, bay leaf, salt, basil and oregano. Cover. Microwave at HIGH (10) 6 to 7 minutes; stir after 3 minutes. Continue to Microwave at... - 34.2071
GETTING READY: 1.Chop onions and cut green chili into small pieces and grind it into a fine paste. And keep aside. 2.Boil the potato and peel it. After It cools cut it into MAKING: 3.Heat oil in a pan and add mustard seeds and curry leaves. 4.Once it... - 0
MAKING 1) In a large saucepan, heat oil. Add in the onions and garlic and saute till they soften. 2) Add in the tomatoes, tomato paste, basil, salt, sugar and water. Stir all well. 3) Let the mixture come to a boil and start bubbling. Turn down the flame.... - 40.3213
If you love making dips then do try out this hummus. It's simple and easy to make. It goes well with wraps, crackers, fresh vegetables or even as a sandwich spread. - 110.99
Need an ultimate comfort food to help you keep warm on a chilly winter night? Take a look at this amazing beef vegetable soup with veggies and spices. All said, but the chef misses out on providing clear vocal step by step instructions for viewers to easily... - 83.0824
1. Make basic cream puff paste. 2. Drop paste by rounded tablespoonfuls into 6 even mounds, 2 inches apart, on an ungreased large cooky sheet. 3. Bake in a hot oven (400°) 40 minutes, or until puffed and golden brown. Remove to wire rack; cool completely. 4.... - 32.34
When you need a healthy, tasty alternative to greasy dips, opt for the truly Mediterranean hummus. Made with garbanzo beans, tahini, garlic and spices, delectable homemade hummus comes together in under 5 minutes. In fact it's so fast you will wonder why you... - 110.209
An all time classic breakfast item - "Idli". Now if u happen to be a South Indian you will already know the ratio of ingredients but what makes these steamed rice cakes different and spongy soft ones you get at restaurants, that just melt in your mouth?... - 124.839
Grind a cupful of peanuts at a time. They should be the consistency of flour. Turn them into bowl. After grinding all peanuts, add only enough oil to blend mixture into thick paste. Salt and/or nutritional yeast may be added, if desired. Pack into... - 26.0898
MAKING 1. In a food processor, place together chickpeas, garlic, lemon juice, tahini paste and half of the olive oil. 2. Process the chickpea and while processing add in the yogurt to make a coarse mixture. 3. Drizzle the remaining olive oil and seasoning and... - 0
Set Power Select at HIGH. In 3-quart glass bowl, heat oil, onion and garlic 1 1/2 to 2 minutes. Add remaining ingredients. Heat, covered with wax paper, 6 to 7 minutes at HIGH. Set Power Select at LOW. Heat, covered with wax paper, 1 hour, stirring... - 39.7661
Chili con carne is one dish that is hard to resist. This thick hearty stew is the ultimate comfort food that can be cooked using leftovers too. Learn how to make this yummy beef dish at home with this recipe video that details step-by-step instructions on how... - 101.77
Thai cooking offers a wide range of sauces to be used or served in or with food and here is a recipe to make one. Check out the chef in the video making traditional Pad Thai Sauce in an easy way that is also easy to store. Great flavorful treat! - 107.852
This is part two of the steamed kale with homemade tahini sauce series. The video is quite interesting and informative. Watch this video that shares some great facts about sea greens and how to use them to make super healthy foods. - 94.8635
To make pastry, knead butter, sugar, salt, egg yolk and flour to make a dough. Cover and refrigerate 30 minutes. On a floured surface, roll out dough to a 10-inch (25-cm) round. Place on a baking sheet. Preheat oven to 400°F (205°C). To make cream puff... - 44.8037
If you are trying your hands at cooking, here is a detailed Homemade Macaroni And Cheese recipe. Everyone loves this dish, so it's good to try something that you like. And in this video, the chef has very detailed instructions so you will feel confident... - 120.989
Want to know how to make caramel apples the healthy way? That's right! There is a way to do that. Now you don't have to worry about being thrown off your diet when you are biting into a chilled caramel apple slice. Watch this video to know more about a recipe... - 123.143
Homemade chocolate hazelnut spread (Nutella style) with fresh hazelnut, dark chocolate, and other ingredients that will make you say yum! - 0
This lovely pizza sauce is a cooked sauce recipe made with a medley of vegetables along with mushrooms. Slow cooked, this pizza sauce is herbed and spiced with italian spices and makes a great topping for any pizza of choice. - 34.424
1. Drain the liquid from the tomatoes into a large saucepan. Reserve the tomatoes. Add the onion and garlic to the saucepan. Bring to boiling over medium heat. Lower the heat and simmer until the onion is tender, about 3 minutes. 2. Stir the tomatoes into the... - 36.0064
A tasty side dish that is mostly eaten for breakfasts along with dosa,idli,vada etc. Dosakaya (yellow cucumber) is always preferred when sour, and not if it is bitter or sweet for such dishes. - 0
MAKING 1) Take a glass casserole and melt butter in it for 30 seconds. 2) Add flour to this and form a smooth paste. 3) Add rest of the ingredients and mix well. 4) Cover and cook for 9 minutes, stirring once. 5) Cover and set aside for 2 minutes. 6) Add dash... - 40.7402
MAKING 1. In a microwave safe bowl, ad the butter/margarine and microwave for half a minute till it melts 2. Add flour and salt to it to make a paste; stir milk into it till smooth, cover amd microwave for another two minutes 3. Keep a watch so as to prevent... - 33.3199
Sauces are key preparations and ingredients in Thai cuisine and here is a recipe to make a Thai sauce. Check out the chef in the video making flavorful Thai Satay Peanut sauce which is a great dipping sauce alongside chicken, tofu dishes, breads, etc. No... - 84.459
This iconic American delicacy that typically consists of beef and loads of cheese is a total treat. Chef Keith Snow shows how to prepare an irresistible bacon cheddar cheeseburger that isn't just dense in taste, but also packs in quite a large wallop of... - 90.7714
Wish to stick to a healthy diet? Then you have to learn to say 'no' to store-bought dressings and make efforts to whomp up some homemade ones to complement your salad. Greg Patent shows what a breeze it is to prepare your own yummy dressings at home using... - 86.9399
This sauce is so garlicky, very flavorful yet not to overpowering. And the consistency is just as thick and creamy as mayo but without the calories of the egg yolk! No bottled sauce comes close to this homemade one. It goes so well with chicken, fish, beef,... - 111.745
Homemade Pizza is an easy yet delicious side dish recipe. Try this Homemade Pizza; I am sure you will get a lot of compliments. - 36.6069
Here in an interesting video that updates you on how to easily make healthy meals for fat loss and vibrant health. This part of the video is informative and introduces to the ingredients required to make steamed kale with homemade tahini sauce. Watch part two... - 96.8938
Lynn demonstrates how to make homemade ketchup. This is an easy and super delicious. This makes about 5 cups. - 0
Delicious and fiery, Kimchi is a Korean staple that is easy to make at home. A Step-by-Step guide to making homemade kimchi has been presented in the video here. It's a healthy, tasty, and refreshing snack and side dish. Go ahead, try making this at home and... - 109.182
Making fresh cultured butter and buttermilk is easier than you think. Start with fresh whole cream, culture it, blend it, squeeze it, flavor it. Homemade butter tastes great and is easy to make! In this video, I also show you how to make unsalted and roasted... - 100.909
Did you know you could make homemade almond butter in a food processor? Raw almond butter can be purchased at most natural food stores, but homemade is more economical and fresh. I like it with celery stalks and raisins (remember Ants on a Log?), smeared on a... - 0
A classic, simple basil pesto recipe with fresh basil leaves, pine nuts, garlic, Parmesan cheese and olive oil. This tastes just like your nonna's recipe. The video gives instructions for making the pesto with a food processor or blender. But if you have the... - 126.537
All of us like pizza but buying it all the time does become a costly affair. Why not try making some at home. The main ingredient of a pizza is the sauce. Here is a quick video that shows how to make pizza sauce at home. The chef shows how to make and store... - 109.688
Here's a quick recipe to make your own hummus from scratch. Just follow my simple steps and you'll be amazed how easy it is to make! - 128.809
So your North American friend is coming over and you want to surprise him with your cooking skills. Then apart from the regional delicacies, treat him with something of his land, delicious shepherd's pie. Yummy, mouth watering and appetizing, this pie... - 109.096
Mac and Cheese is an all-time favorite. It is one of the most ordered dishes at any diner. The best part about making your own homemade Mac and cheese is that you can make it exactly the way you like it. Ronnie Woo shows his way of making Mac and Cheese and... - 137.6
If you are wondering what to do with the pound of ground beef sitting in your refrigerator, why not make Sloppy Joes? A sandwich is a sandwich but a Sloppy Joe is a total meal. Where are you going to go and buy one of these? If you want one, you probably have... - 169.84
MAKING 1) In a large skillet, heat oil. Add in the onions and garlic and saute till they soften. 2) Add in the beef and sausage. Brown on all sides. 3) Retain 2 tablespoons of fat in the skillet and drain off the rest. 4) Into the skillet, add in tomatoes,... - 44.0694
MAKING 1) In a large kettle, add in the olive oil, vegetable oil, butter or margarine and lard. 2) Add in the chuck or round along with the sausage, a few pieces at a time. Once browned, remove them onto a paper towel. 3) Add in the onion, garlic and carrots... - 42.6866
Wipe and trim the meat and flatten it with a rolling-pin. Season the forcemeat well, spread it on the meat, and roll up tightly and tie securely. Heat the fat in a saucepan until very hot and fry meat quickly until the whole surface is browned. Add the hot... - 33.5252
GETTING READY 1. Preheat oven to 350°. MAKING 2. Take a bowl, mix garlic and salt to a paste and keep aside. 3. In a large mixer bowl or food processor bowl, beat butter, cream cheese, pepper, garlic mixture, pepper and parsley to a smooth mixture. 4. Cover... - 41.4116
MAKING 1. In a large, deep pan heat oil. 2.Saute the onions, ginger, garlic and chilli for 10-15 minutes until soft. 3. Put in the rest of the ingredients along with some seasoning, then boil for 30 minutes, stirring occasionally, until thicken. 4. Allow to... - 46.5444
GETTING READY: 1.In a bowl add all the above ingredients and mix it well (sprinkle water to get a soft,thick consistency ) MAKING: 2.Heat oil in a thick bottomed pan (kadai). 3.Drop small quantities of the batter in the oil and deep fry it into golden... - 0
Traditionally, people prefer to cook ribs in barbecue pit. And in this video recipe, Ryan Karcher tells you how. Never bind if you don't have barbecue pit at home. You can get the same delicious result by preparing the ribs in oven too. A heart addition to... - 87.5518
If you are looking for a yummy homemade alternative to store-bought burgers, this steakhouse burger could fit your bill. Tastier than traditional burgers, this lip-smacking burger includes a load of assembling and arranging, but the effort is all worth it. - 107.848
If you prefer homemade sauces over the readymade ones, then this recipe is for you. You can make this BBQ sauce super special, just by adding some dark rum into it. To learn the detail procedure, watch the video. - 102.971
Who doesn't want a personalized mustard sauce recipe. Here's one just for you. Watch the chef share a Homemade Classic Mustard Sauce recipe that can be easily prepared in your own kitchen. Enhance the taste of your sandwiches and appetizers with this... - 90.7453


text: Crowne Plaza La Concha Resort Hotel rating Quick Specs Commissions 10.0%Rates $299-$729Year Built 1926Year Renovated 2011 View Large Interactive Map Address 430 Duval StKey West, FL 33040 Web http://www.laconchakeywest.com Phone + 1 305-296-2991 Fax + 1 305-294-3283 Toll-free 800-745-2191 Email firstname.lastname@example.com OverviewMeeting SpecsPhotos & videosRatings & Reviews Description Restored Art Deco Hotel set in the heart of Old Town, 4 blocks from Gulf of Mexico.Year Built: 1926Year Renovated: 2011Check in Time: 4:00 PMCheck out Time: 11:00 AMNumber of Floors: 7Total Number of Rooms: 160Rates: $299-$329Commissions: Room Only 10.0%Chain: Crowne Plaza Hotels & ResortsChain Website: http://www.crowneplaza.com GDS Hotel Reservation CodesAmadeus GDS: CP EYWA75Galileo/Apollo GDS: CP 02100Sabre GDS: CP 002027WorldSpan GDS: CP 2677 Crowne Plaza La Concha Resort Location & Neighborhood150 miles from Miami, FL. In center of attraction area, old town historic location. Beach. Crowne Plaza La Concha Resort Rates & PoliciesCrowne Plaza La Concha Resort rates are Daily in USDStandard: $299-$329 (USD) Suite: $529-$729 (USD) Credit Cards Are AcceptedReservations must be guaranteed with a credit cardMeals: No Meals IncludedDeposit Policy: 1st night's depositCancellation Policy: 72 hr advance of arrivalHotel Discounts offered: Group discountCorporate discountGovernment/ Military discountAARP discount Nearby AirportsKey West Intl (2.75 miles east)Juan Gualberto Gomez (107.50 miles southeast)Naples Mncpl (110.25 miles north)More Airports » Crowne Plaza La Concha Resort Room AmentitiesCrowne Plaza La Concha Resort amenities are in All rooms unless noted otherwiseAir ConditioningBalcony/Terrace (some)CoffeemakerDaily Maid ServiceRooms for Non-smokersTelephoneCable/Satellite TelevisionTelevisionInternet Access (High Speed & Wireless) (additional fee) Guest ServicesATM/BankComplimentary CoffeeConcierge ServicesGift ShopLaundry/Dry Cleaning ServiceMulti-lingual StaffPaid Onsite ParkingRoom ServiceWheelchair Access to Common/Public AreasCommon Area Internet Access (High Speed & Wireless) (additional fee) Security ServicesSmoke Alarm in RoomsSprinkler in Rooms Nearby SightseeingKey West Marine ParkKey West Turtle Cannery MuseumReef Relief Environmental CenterThe Oldest House MuseumNancy Forrester's Secret Garden (0.25 miles southeast)More sightseeing »DiningJimmy Buffett's Margaritaville CafeBlue HeavenTurtle Kraals Restaurant & BarA&B Lobster HouseAlonzo's Oyster BarMore dining options » On-Site RecreationBicyclingHealth ClubPool (Outdoor Pool)Nearby RecreationBeachBoating/SailingFishingGolf CourseJogging TrailsScuba DivingShopping Mall/AreaSnorkelingTennis (Outdoor Tennis)Water Skiing Crowne Plaza La Concha Resort Meeting Rooms & Events3 Meeting Rooms holding 175 people.2,776 sq ft of Meeting Space2,825 sq ft of Exhibit SpaceLobbyFlooring: tile/carpetCapacity: , Reception- 184, Banquet- 140TopLocation: Floor 7Flooring: carpetCapacity: Theater- 200, Classroom- 60, U-Shape- 40, Reception- 200, Banquet- 160IslandFlooring: carpetCapacity: Theater- 66, Classroom- 35, U-Shape- 16, Reception- 45, Banquet- 45CoralFlooring: carpetCapacity: , Classroom- 8, Reception- 20, Banquet- 20 Crowne Plaza La Concha Resort Business ServicesA-V EquipmentCopierFaxMeeting FacilitiesMeeting Room Internet Access (High Speed & Wireless) (additional fee) Crowne Plaza La Concha Resort Images, Videos, & Virtual Tours travel42 Review for Crowne Plaza La Concha Resort Want to read the full Crowne Plaza La Concha Resort travel42 Review? For access to this review as well as 10,000 others, visit www.travel-42.com or call 1.866.566.8136 to subscribe. This island landmark, also known as La Concha, is the tallest hotel here and one of the most commercial, too. This chain may not be well-known for its resorts, but this property provides a dependable base for both leisure and business travelers. Renovations are moving through the guest rooms, which are resurfacing with a fun and stylish tropical-contemporary look that is creating a positive spark in the eyes of returning guests. In spite of modernization, the hotel retains its fun-loving spir... Subscribe to travel42 to read the full review » Copyright (c) 2014 Northstar Travel Media, LLC. travel42. Nearby Key West Hotels More Nearby Hotels Southernmost on the BeachAlexander's GuesthouseBanana Bay Resort-Key WestBest Western Key Ambassador Resort InnCoconut Beach ResortCourtyard by Marriott/WaterfrontHeron HouseHyatt Key West Resort & SpaLa Mer Hotel & Dewey HouseMarquesa HotelParrot Key ResortPier House Resort & Caribbean SpaSheraton Suites Key WestSimonton CourtThe Banyan ResortThe Gardens HotelThe Ocean Key Resort & SpaThe Reach, A Waldorf Astoria ResortThe Paradise Inn Hoteliers! Is your listing up to date? With over 130,000 hotels in our database, no other source compares to our depth of information. Click here to review and be sure the travel professional knows your hotel's latest details.