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Project 1
Epigenetics of Drug Resistance in Acute Leukemia (AML)
Jean-Pierre Issa, M.D.
Co-Project Leader, Basic Research
Hagop Kantarjian, M.D.
Co-Project Leader, Clinical Research
Genesis of the Project
DNA methylation and associated epigenetic changes lead to functional alterations in pathways that promote neoplastic development. Therapy targeting DNA methylation and histone deacetylation, another epigenetic modification, has shown activity in myeloid leukemias, and is now part of standard of care in patients with myelodysplastic syndrome (MDS). We have identified a DNA hypermethylation signature that characterizes young patients with acute myeloid leukemia (AML) who have a high cure rate following standard cytotoxic chemotherapy. This signature was independent of known prognostic factors and, if validated, would provide an important tool towards personalized therapy in AML. Separately and paradoxically, we have shown that progression in AML (diagnosis to relapse) and in MDS (MDS to AML) is also associated with the progressive acquisition of aberrant DNA methylation that, in this situation, predicts for a poor overall outcome. Finally, in proof-of-concept studies, we have shown that treatment with the DNA methylation inhibitor DAC results in tumor-suppressor gene demethylation and reactivation in AML and MDS, associated with a relatively high response rate that correlates with induction of gene expression of the P15 tumor-suppressor. Based on these observations, we hypothesize that DNA methylation profiling identifies a subset of young patients with AML who are curable with standard chemotherapy. We further hypothesize that DNA methylation, through separate genes, also contributes to clonal evolution in AML, leading to relapses with drug resistant phenotypes, and that DNA methylation inhibition in remission will delay or eliminate clonal evolution and disease relapse in some patients. Finally, we hypothesize that strategies aimed at enhancing pharmacologic epigenetic reactivation will translate into better therapies for myeloid malignancies. To test these hypotheses, we propose the following specific aims: (1) Retrospectively and prospectively validate and extend an epigenetic signature of curability in AML. (2) Conduct a randomized clinical trial of remission maintenance in AML using DAC. (3) Use a methylated and silenced GFP reporter gene selectable system to identify key pathways and pharmacologic combinations that lead to epigenetic reactivation in neoplastic cells. This project will provide new markers of prognosis in AML and new approaches to therapy that are based on incorporating epigenetic modulation into the standard of care of this disease.
Translational Relevance
This project will extend the progress in our previous funding period to: (i) develop validated tests that can be used for individualized therapy in AML, (ii) improve the survival of patients with AML through integrating epigenetic therapy into standard of care, and (iii) develop new drug combinations that build on and extend the success of epigenetic therapy in the clinic. Specific translational objectives are aim 1: A validated epigenetic signature that predicts curability would allow personalized medicine by channeling curable patients to standard approaches and non-curable patients to alternate approaches. Identifying the genes responsible for curability in AML would allow the design of strategies to increase the cure rate in this disease. Aim 2: Relapse after induction remission accounts for most deaths in AML. Reducing relapses by the clinical approach outlined would increase the cure fraction in this disease. The pharmacodynamic endpoints may identify patients most likely to respond to this approach. Aim 3: Modulating epigenetics is now part of the standard of care in some leukemias. Discovering new drug combinations and pathways that lead to enhanced gene reactivation would provide new/improved therapeutics in leukemias. The lessons learned in this project are already being extended to other leukemias (MDS, ALL, CML) and the proof of principle studies as well as the methodology developed/utilized have implications for the management of patients with other malignancies.
Introduction of the Co-Project Leaders
The co-project leaders are Jean-Pierre Issa, M.D., and Hagop Kantarjian, M. D. Dr. Issa is Director at Fels Institute in Philadelphia and is widely known for his research on DNA methylation and epigenetic changes in malignancies. Dr. Kantarjian is chair, Department of Leukemia, at MD Anderson, and is a recognized leader in clinical research in hematologic malignancies.
Project 2
Adoptive Cellular Therapy for Myeloid Leukemia
Jeffrey Molldrem, M.D.
Co-Project Leader, Basic Research
Richard Champlin, M.D.
Co-Project Leader, Clinical Research
Genesis of the Project
There is increasing evidence that lymphocytes can target and inhibit myeloid leukemia cells both in the allogeneic and autologous settings. The potent graft versus leukemia (GVL) effect associated with allogeneic stem cell transplant (SCT) conveys activity against leukemia and contributes to the decreased relapse risk compared with patients who do not receive an allogeneic graft. While GVL can induce long-term remission, the potentially lethal complication of graft-versus-host disease (GVHD) limits overall effectiveness of this treatment approach. We hypothesize that GVL would be enhanced, and GVHD reduced or eliminated, if the target antigens that drove those responses were identified, and if T cells with GVL antigen specificity could be isolated and adoptively transferred to patients with leukemia in the allogeneic setting, and that this effect could be increased by vaccination with appropriate leukemia antigens. We have identified an HLA-A2-restricted nonomer peptide, PR1, as a target antigen of CTL that inhibits myeloid leukemia progenitors and kills myeloid leukemia bone marrow cells. We have found that PR1 is processed from both proteinase 3 (PRTN3) and neutrophil elastase (ELA2), which are aberrantly expressed in leukemia. After vaccination with PR1, immune responses were observed in the majority of patients, and persistent remission was documented in some patients with AML, CML, and MDS. Immune-based therapies with low toxicity could be useful in combined treatment strategies to induce remission in patients with leukemia in the allogeneic setting to enhance GVL and minimize GVHD. In this proposal, we will (1) determine whether phenotype, function, and T cell receptor (TCR) affinity differ between PR1-CTL elicited after vaccination compared to those derived from healthy donors; (2) determine whether aberrant trafficking of PRTN3 and ELA2 can reverse tolerance and facilitate the expansion of central memory PR1-CTL; and (3) determine whether PR1-CTL expressing high affinity TCR can be transferred to patients with AML after T cell-depleted haplo-identical SCT to boost GVL and diminish GVHD.
Introduction of Co-Project Leaders
The co-project leaders are Jeffrey Molldrem, M.D., and Richard Champlin, M.D. Dr. Molldrem has made major contributions in tumor immunology, myeloid leukemia, myelodysplastic syndromes and immunotherapy. Dr. Champlin, chair of the Stem Cell Transplantation Department at MD Anderson has made several seminal observations and discoveries in the field of allogeneic SCT. His major goal is to improve the efficacy and reduce the risks of hematopoietic transplantation for treatment of hematopoietic malignancies and selected solid tumors.
Translational Relevance
The highly translational components of this proposal are: (1) we will directly study sample material from patients with leukemia who have received many different treatments including the PR1 vaccine that was identified in our laboratory, (2) knowledge gained about affecting PR1 immunity by subcellular antigen processing elements can be immediately tested in patients, and (3) techniques developed in the previous grant period to expand PR1-CTL ex vivo will be tested in SCT recipients. Therefore, the studies in this proposal depend upon studying patient material to understand mechanisms of immunity versus tolerance. Most importantly, we will directly test our hypotheses in clinical trials in leukemia.
Project 3
P53 Activation as Novel Therapeutic Strategy for Acute Myelogenous Leukemia
Michael Andreeff, M.D., Ph.D.
Co-Project Leader, Basic Research
Marina Konopleva, M.D., Ph.D.
Co-Project Leader, Clinical Research
Kensuke Kojima Ph.D.
Co-Project Leader
Genesis of the Project
The main therapeutic challenge in the treatment of myeloid leukemias is the development of strategies that maximize the induction of leukemia cell apoptosis before resistance to chemotherapy develops. p53 is the master switch that determines whether a stressed cell undergoes apoptosis, thus acting as a tumor suppressor. p53 mutations lead to inactivation of this suppressor function. Mouse Double Minute 2 (HDM2) and its homolog HDMX can also inactivate p53 activity: while HDM2 is an ubiquitin ligase that mediates degradation of p53 by ubiquitin-mediated proteolysis, HDMX inhibits the transcriptional activity of p53. p53 mutations leading to p53 inactivation are rare in newly diagnosed and relapsed AML. There is a reported loss of p53 function through over-expression of HDM2 in approximately 50% of AML cases; expression of HDMX have not been investigated in AML. Restoration of p53 activity by inhibiting HDM2/p53 interaction utilizing non-genotoxic small molecule inhibitors (Nutlin 3a, MI 63) induces apoptosis in AML cells with unmutated p53. While these HDM2 inhibitors dramatically increase p53 levels that initiate transcription of p53 targets, transcription-independent direct interactions of p53 with Bcl-2 family members also occur. Furthermore, chemotherapeutic agents such as cytarabine and daunorubicin syngergize with BH3 mimetics, and with MAPK inhibitors, which inhibit induction of anti-apoptotic p21 and regulate the subcellular distribution of p53. Thus, we propose to investigate the molecular and clinical consequences of a clinical trial with small molecule inhibitors of HDM2 (Nutlin 3a, MI-63) and to develop a better understanding of the mechanisms regulating p53 activation and the observed synergism with chemotherapy. If successful, these studies will provide rationale for a novel therapeutic strategy in AML based on the non-genotoxic activation of p53 signaling. Specific Aim 1: Identify the molecular determinants of apoptosis induced by non-genotoxic small molecule inhibitors of HDM2 (Nutlin 3a, MI 63) in leukemia cell lines, primary leukemia cells and stem cells. Specific Aim 2: Determine mechanisms by which HDM2 inhibition synergizes with chemotherapy (Ara-C, Doxorubicin) in AML. Specific Aim 3: Conduct first-in-man Phase I trial of HDM2 inhibitors (Nutlin 3a analog R7112, MI 63) in AML.
Introduction of Co-Project Leaders
The co-project leaders are Michael Andreeff, M.D., Ph.D., Marina Konopleva, M.D., Ph.D., and Kensuke Kojima, Ph.D. Dr. Andreeff is a well-known physician-scientist whose expertise is in strategies targeting apoptosis pathways in malignancies, development of cytokine-chemotherapy combinations and multidrug resistance-blocking strategies and the comprehensive analysis of cell signaling, proliferation and apoptosis pathways in leukemia. Dr. Konopleva is a hematologist/scientist who has made important discoveries in leptin receptor and apoptosis signaling in leukemia, and has developed PPARg as a molecular target in leukemia. Dr. Kojima is a scientist and has been one of the pioneers in bench-to-bedside translation of MDM2 inhibitors.
Translational Relevance
This project aims at introducing an entirely novel concept into cancer and leukemia therapy: the activation of p53 signaling by pharmacological disruption of the HDM2/p53 protein-protein interaction. We have strong preclinical in vitro and in vivo evidence that disruption of MDM2/p53 induces transcription-dependent and –independent apoptosis in cells with wild-type p53 (utilizing Nutlin 3a from Roche and MI 63 from Ascenta). We found strong synergism with chemotherapy, with Bcl-2 inhibitors such as the BH3-mimetic ABT-737, and with MAPK inhibitors. This proposal aims at better understanding the roles of HDM2 and HDMX, both p53 inhibitors by different mechanisms, of baseline wt p53 levels, and of Arf and NPM1 mutations in this process. These studies will be conducted in vitro in cell lines and in patient samples and in patients with refractory/relapsed AML in a first-in-man clinical trial. The first clinical trial (Aim #3) will determine DLT, MTD and PK of R7112 (a Roche Nutlin 3a analog given orally) and will investigate the impact of the molecular determinants of sensitivity and resistance investigated in Aim #1. Aim #2 will conduct mechanistic studies of HDM2 inhibitor/ chemotherapy combinations and will provide the framework for an anticipated clinical trial in AML. The translational objectives, therefore, are the introduction of MDM2/p53 inhibitors into hypothesis-driven clinical trials.
Project 4
PPAR-gamma Nuclear Transcription Factor: A Novel Target for Leukemia Therapy
Mark Levis, M.D., Ph.D.
Co-Project Leader, Basic Research
Don Small, M.D., Ph.D.
Co-Project Leader
Genesis of the Project
Internal tandem duplication mutations in the FLT3 receptor tyrosine kinase (FLT3/ITD mutations) are one of the most common molecular abnormalities in acute myeloid leukemia (AML) and are associated with significantly worse clinical outcomes. Several different small molecule FLT3 inhibitors have been studied in AML patients, and most have shown limited but consistent clinical effects. These inhibitors span a wide range of chemical classes and vary considerably in selectivity for FLT3. Our previous studies have demonstrated that FLT3 inhibition combined with chemotherapy leads to synergistic cytotoxic effects against FLT3 mutant AML cells, and that FLT3 mutations are present in leukemia stem cells (LSCs). Preliminary results from ongoing clinical studies of FLT3 inhibitors in relapsed AML patients suggest that chemotherapy followed by successful FLT3 inhibition leads to clinical benefit. These results are not surprising given the clinical successes of several recently approved tyrosine kinase inhibitors in a variety of cancers, but our findings have raised a number of questions of immediate importance. To what degree does FLT3 need to be inhibited for maximal benefit? Will more or less selective FLT3 inhibitors offer the best combination of tolerability and efficacy when given in combination with chemotherapy? When during the course of AML therapy should the FLT3 inhibitor be administered? Are FLT3 inhibitors effective against LSCs, and if so, under what conditions? This proposal aims to address these questions in the context of clinical trials that are either ongoing or are about to begin accruing patients. The broad goal of this proposal is to better understand how to incorporate FLT3 inhibition into AML therapy so as to improve survival and cure rates for FLT3 mutant AML.
Introduction of Co-Project Leaders
The co-project leaders for this project are Mark Levis, M.D., Ph.D., and Don Small M.D., Ph.D. Dr. Levis, is a well-known physician-scientist who's expertise include signal transduction biology, molecular pharmacology, and the clinical management of leukemia . His interests are in the use of agents targeting receptor tyrosine kinases for the treatment of acute leukemia, primarily AML. His laboratory research focuses on how these agents can be successfully incorporated into existing treatment regimens. Dr. Levis has over ten years of experience conducting correlative laboratory studies of clinical trial specimens and directly coordinating clinical trials in AML. Dr. Small is an acknowledged leader in the area of FLT3 studies in AML. His efforts in the laboratory have culminated in the current human trials of FLT3 inhibitors in AML. He was the first to clone the human FLT3 gene, and he has continued to investigate its role in leukemic transformation. His laboratory was the first to show that small molecules could inhibit FLT3 tyrosine kinase activity, thus interfering with signaling.
Translational Relevance
FLT3 inhibition continues to show great promise for improving the survival of a defined subset of AML patients. Five years ago, we proposed to study the response of AML patients to FLT3 inhibitors as our project on the leukemia SPORE. Currently, as a direct result of our "bench to bedside" research, two separate phase III trials of FLT3 inhibitors are underway (Cephalon 204 and MRC AML15). While these trials may ultimately lead to the approval of CEP-701 for use in AML, their optimal use will still only be crudely defined. At this point, "bedside to bench" research is needed to optimize the dosing and schedules of these drugs, as well as to better understand why they work and in which patients they should work best. For the continuation of this project we propose to determine the optimal way of incorporating FLT3 inhibitors into current AML therapy. Our translational objectives are to establish the degree of FLT3 inhibition necessary for achieving the best clinical responses, and to identify a FLT3 inhibitor that, when combined with chemotherapy, offers the best combination of efficacy and tolerability. We also wish to determine which FLT3 inhibitors, if any, are effective against leukemia stem cells. By studying the response of leukemia stem to FLT3 inhibition, alone and in combination with chemotherapy, we can predict whether or not an outright cure can be achieved with this approach, or if, instead, maintenance therapy with a tolerable, potent FLT3 inhibitor is effective at suppressing the re-expansion of the leukemia stem cells.
Project 5
Development of Sapacitabine Therapy in Leukemias
William Plunkett, Ph.D.
Co-Project Leader, Basic Research
Hagop Kantarjian, M.D.
Co-Project Leader Clinical Research
Genesis of the Project
Effective therapies for acute leukemias have been developed incrementally, advanced by the development of agents with different mechanisms of action. Sapacitabine, the orally bioavailable form of CNDAC (2'-С-cyano-2'-deoxy-1-β-D-arabino-pentofuranosyl- cytosine), is a potent cytosine nucleoside analogue with a novel mechanism of action. The design of CNDAC was based on the concept that once its triphosphate is incorporated into DNA, the addition of a subsequent deoxynucleotide would initiate β-elimination, resulting in cleavage of the 3'-5' phosphodiester linkage and conversion of incorporated analogue to a chain-terminating nucleotide, CNddC. Clinically active in phase I studies, the mechanisms of action of sapacitabine are unique among therapeutic agents, as it causes a single strand nick in DNA that is terminated by a nucleotide that cannot be extended and is resistant to repair. Our hypothesis is that sapacitabine will elicit novel pharmacodynamic responses for detecting DNA damage, for repair of the lesions, and for activation of cell cycle checkpoints that will serve as biomarkers to guide clinical development of sapacitabine alone and in combination with targeted inhibitors of these pathways. We will conduct translational studies in primary leukemia cells in vitro and during therapy that will complement and extend ongoing laboratory investigations. The specific aims for testing this hypothesis are: 1. Evaluate pharmacokinetics and pharmacodynamics of sapacitabine during phase I/II clinical trials in patients with relapsed/refractory leukemias, 2. Characterize biomarkers for cellular responses to sapacitabine, 3. Formulate laboratory rationales for clinical translation of mechanism-based combinations of sapacitabine with small molecule inhibitors. The overall goal of our proposal is aimed at developing a thorough understanding of cellular responses to sapacitabine that will identify biomarkers that have prognostic value to optimize patient selection and schedules of administration in the clinic, and to provide rationales for combinations with agents targeted at inhibiting DNA damage sensors, DNA repair mechanisms, and dysregulating checkpoint controls.
Introduction of Co-Project Leaders
The co-project leaders are William Plunkett, Ph.D., and Hagop Kantarjian, M.D. Dr. Plunkett's research has focused on matching the metabolism and mechanisms of action of drugs to the pathophysiology of chronic lymphocytic leukemia. Dr. Kantarjian is Chairman of the Department of Leukemia and over the past 30 years he has developed chemotherapeutic and biologic agents in leukemias and contributed to the development of others.
Translational Relevance
Characterization of the plasma and cellular pharmacology of sapacitabine will provide information essential to the evaluation of single agent trials, and for the design of combination therapies. Investigations in primary leukemia cells will identify biomarkers to demonstrate leukemia responses to sapacitabine that will be evaluated for prognostic value in clinical trials. Finally, investigations of sapacitabine in combination with inhibitors of cellular responses to its actions will provide a mechanistic rationale for the design of clinical trials of the combinations, and also for the identification of patients with disease characteristics predictive of response to sapacitabine.
Core A
Hagop Kantarjian, M.D.
Jean-Pierre Issa, M.D.
Genesis of the Core
We believe that the projects described above represent innovative, well designed, hypothesis-driven and highly feasible multidisciplinary translational research. To accomplish this research, we must have scrupulous administration, open communication and meticulous fiscal oversight. These are the goals of Core A.
Introduction of the Co-Leaders
The co-leaders of Core A are the two co-leaders for the Leukemia SPORE, Hagop M. Kantarjian, M.D., and Jean-Pierre Issa, M.D. Dr. Kantarjian is a well-known physician-scientist whose expertise is in developmental therapeutics in leukemia. Dr. Issa is an eminent researcher who has made major contributions to the area of mechanisms of methylation in cancer. Both co-leaders have extensive experience in the successful conduct of large-scale translational research studies in leukemia.
Core B
Pathology and Tissue Core
Steven Kornblau, M.D.
Jean-Pierre Issa, M.D.
Carlos Bueso-Ramos, M.D.
Effective tissue procurement and utilization is vital for meaningful translational research activities. The Pathology and Tissue Core will work with each SPORE project and the Biostatistics and Data Management Core to ensure efficient and highly coordinated procurement, use and storage of blood and bone marrow samples. The Core will obtain and maintain a repository of blood samples (including peripheral blood, bone marrow biopsies and bone marrow aspirates) for laboratory use, with an effective coding system for all laboratory specimens to ensure patient confidentiality and prevent experimental bias. Continuous communication between the investigators, research nurses, biostatisticians and hematopathologists, as well as standardized operating procedures for activities will provide for optimal tissue collection and accurate processing, analysis and storage of each sample. Thus, the functions of the Pathology and Tissue Core are to facilitate acquisition, preservation, analysis and dispersal of clinical samples and to provide hematopathologic characterization and specimens for all project investigators.
The Tissue Procurement and Hematopathology Core has the following objectives:
- Develop and maintain a repository of blood and bone marrow specimens, including intact cells, serum, cellular DNA, RNA and protein, from patients with leukemia and MDS (including patients who are newly diagnosed, in remission or in relapse) receiving care or evaluation at MD Anderson Cancer Center
- Distribute tissue specimens to SPORE investigators for analysis and provide expertise in the interpretation of studies performed on tissue sections within SPORE projects
- Provide comprehensive histologic characterization of blood and marrow samples used in SPORE projects, including specimens from patients entered onto clinical protocols
- Maintain a comprehensive, prospective interactive database with detailed clinical and pathologic data for patients with leukemia and MDS receiving care or evaluation at MD Anderson Cancer Center
- Facilitate inter-SPORE collaborations through sharing of blood and marrow resources.
Core C
Biostatistics and Data Management
Donald Berry, Ph.D.
Xuelin Huang, Ph.D.
Genesis of the Core
Expert assistance with biostatistical and data management issues is essential to the design and conduct of translational research studies. This support involves issues of study design, including appropriate sample size for primary objectives, power for detecting alternative hypotheses, identifying unmet needs, developing new methodology for biomarker-integrated translational studies and monitoring the conduct and possible early termination of such studies. Once data are collected, they must be efficiently entered, managed and stored with the highest integrity and attention to data quality, safety and confidentiality. These are the goals of the Biostatistics and Data Management Core.
Introduction of the Core Co-Leaders
Donald Berry, Ph.D., is a renowned expert in the field of statistical design and analysis of translational cancer trials. The co-leader, Xuelin Huang, Ph.D., and Dr. Berry have served as the principal statisticians in leukemia trials, and have extensive experience in collaborating with the SPORE investigators. Dr. Huang has designed 50+ clinical trials and reviewed 100+ clinical trial protocols.. He is extremely knowledgeable about leukemia, previous studies, existing databases and needs, and is best positioned to assist Dr. Berry and the Leukemia SPORE in the biostatistical needs.
Development Research Program
Jean-Pierre Issa, M.D.
Hagop Kantarjian, M.D.
Genesis of the Program
To assure that the Leukemia SPORE retains its translational relevance and impact, the SPORE leadership must be ready to re-engineer or discard projects that fail to live up to their original potential. Replacement projects will be developed through the Leukemia SPORE Developmental Research Program. The primary goal of this program is to perform new and innovative small-scale research studies in order to develop new projects that can be used to replace any non-performing SPORE projects. Through the Developmental Research Program, researchers will be encouraged to test new approaches and take intellectual risks relevant to leukemia research.
Introduction of the Directors
The director of this program is Jean-Pierre Issa, M.D. The co-director is Hagop M. Kantarjian, M.D. Dr. Issa is an eminent researcher who has made major contributions to the area of leukemia methylation and its significance in cancer. Dr. Kantarjian is a distinguished physician-scientist with a strong record of translational research and developmental therapeutics in leukemia.
Career Development Program
Hagop Kantarjian, M.D.
Jean-Pierre Issa, M.D.
Genesis of the Program
Training and mentoring of young investigators, and the support of their research efforts, is a primary mission of the Leukemia SPORE. Dr. Kantarjian and his senior investigators have a long history of mentorship. Through the SPORE Career Development Program, senior medical or laboratory-based postdoctoral fellows and junior faculty who wish to develop careers in translational leukemia research will be recruited. Exceptional, established senior faculty who wish to redirect or extend their ongoing research programs to include leukemia translational cancer research will be eligible for this program.
Introduction of the Directors
The director of this program is Hagop M. Kantarjian, M.D. Jean-Pierre Issa, M.D., will serve as co-director. Dr. Kantarjian is a well-known physician-scientist whose expertise is in leukemia developmental therapeutics. Dr. Issa is a distinguished physician-scientist with a strong record of translational research in methylation and leukemia.
Projects, Cores and Programs
Project 1: Epigenetics of Treatment Resistance in Acute Leukemia
Project 2: Adoptive Cellular Therapy of Myeloid Leukemia
Project 3: Concerted Blockade of Oncoprotein Activity
Project 4: PPAR-gammaNuclear Transcription Factor: A Novel Target for Leukemia Therapy
Project 5: Molecular Epidemiology of AML
Project 6: Response of AML Patients to FLT3 Inhibitors
Core B: Pathology and Tissue Core
Core C: Biostatistics and Data Management Core


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Thread: 2002 K2500 rear interior
2002 K2500 rear interior
Last edited by stephenwsmith; 10-26-2011 at 05:54 PM.
10-26-2011, 10:14 PM #2Kinda looks like the mounts for a 3rd seat..... but they look a little too close to the seat in front.....
Airforce Veteran (7 years)
NRA Life Member
10-27-2011, 04:40 AM #3Has anyone here ever put in the brackets for the third row of seats into a Suburban like this (A Government 2002 k2500?)
- Join Date
- Apr 2011
- Location
- Thornton, Colorado, United States
- Posts
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That's the machine gun mount. You did say it was the Govt edition.
Could it be an alternate position for the seat?Alan
2010 GMC Sierra SLT
2007 Chevy Suburban LTZ 4WD, aka BB
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text: Edit profile History Add ImageHarry Potter and the Deathly Hallows Part 2 was the best movie of all time, and for anybody reading this do you agree, even though the length of the film was good, do you feel it should have been spectacular enough to be 3 hours long? Http www.youtube.com watch?v=e4EcMgCm PA(01:51)Yeah cos like destroying a horcrux and almost dying turns me on too. And sorry for the replay of the kiss, not intentionalAdded by Jprest1999 My favorite pages Harry Potter and the Deathly Hallows: Part 2 Death Eaters Horcrux Arthur Weasley


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Lavender Milk Steamer - this soothing and relaxing drink will help you sleep as we prep for Daylight Savings Time this weekend.
#22426Guinness Chocolate Cupcakes, dark chocolate Jameson Ganache, topped with sweet Bailey's buttercream - boozy 'shot'cakes, perfect for St. Patrick's Day, or a 21st celebration!
#22425Pan-seared shrimp over peanut sesame salad, with a sprinkling of crispy ginger and garlic!
#22424Lemon cupcakes with a surprise- there's sweet and tart lemon curd hiding below those swirls of vanilla frosting!
#22418Quick Mini Monkey Breads (Pull-Apart Scone Doughnuts) - chocolate chip scone dough, rolled in cinnamon-sugar, topped with caramel or nutella
#22415Almond Joy's got nuts. Mounds don't. These Almond Joy Brownies have it all - chocolate, coconut, and almonds.
#22414Korean-Style Steamed Eggs - When steamed in a hot water bath, thes eggs set into the loveliest custard with the texture of silken tofu.
#22408Brown Butter Grilled Cheese Sandwich - brown butter seals the deal on this delicious sandwich.
#22407Chocolate and citrus and sugar, oh my! A three-cookie platter for a potluck dessert table, including these two-bite cocoa and coconut bits.
#22406Skinny Cheesecake - almost 5 times less calories than your average cheesecake. Two different methods to make it!
Chili Mac combines two great comfort foods into one bowl - chili and mac and cheese
#22399The classic French Onion Soup. It takes some patience, but is easy to make and totally worth it!
#22398Chicken Tikka Masala - a delicious version of the classic dish, made with coconut milk.
#22393Just like the shake you remember but better! This Shamrock Milkshake is creamy, minty and delicious!
#22391Banana Rum Cake with Brown Butter Frosting. There's rum in the cake AND the frosting...need I say more?
#22388Venison osso bucco prepared from an adapted 4th Century Roman recipe. Exotic, fruity and delicious!
#22387Swedish Pancakes with Lingonberry Jam - a delightful Easter breakfast option
#22384Beetroot & Red Wine Risotto with Oregano & Seared Halloumi, inspired by a trip to the Holden Manz wine estate in Franschhoek
#22383Smoky roast eggplant with tahina and pomegranate seeds - vegetarian, vegan, parve, and gluten free!


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February 6, 2009
Toronto-based Green Ride Global has recognized Pure Luxury Transportation for Environmental Excellence for Overall Greenhouse Gas Emissions Reduction and Client Outreach and Awareness. The awards were presented at a Green Ride Global member reception at this year's International Limousine and Chauffeured Transportation show in Las Vegas. Pure Luxury was recognized with one award for meeting or exceeding its annual Greenhouse Gas (GHG) reduction targets, and another for demonstrating high-level engagement and education of their clients, partners and stakeholders around their environmental commitments.Early in 2008, Pure Luxury Transportation committed to annual GHG emissions reductions of two percent per year from 2007 levels. To date, the company is on track to exceed its first-year target by 14 percent. As members of Green Ride Global, Pure Luxury Transportation is part of the U.S. EPA Climate Leaders program and has implemented an environmental management system that is ISO 14001 compliant.
Toronto-based Green Ride Global has recognized Pure Luxury Transportation for Environmental Excellence for Overall Greenhouse Gas Emissions Reduction and Client Outreach and Awareness.
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Davwud G's Country Kitchen's Fried Chicken is legendary 'round these parts Crispy and encasing the simply seasoned bird this fried chicken is all about the bird flavour. Very good. (crappy photo) DT
Potato Salad
Mashed Potatoes
Great Northern Beans
Pinto Beans
Green Beans
Collard Greens
Macaroni & Cheese
SassyGritsAL Big Springs is one of my fav. places for burgers. They are the "Home of the Greasy Burgers" and I crave them. I am a big white sauce fan, not only do I use it for chicken but I put it on my bbq and dip my hushpuppies in it. Glad you enjoy the restaurants in Huntsville and if you get a chance try one of my fav. - Dallas Mill Deli (they are on FB) and Greenbrier BBQ restaurant (there are two - one right off the interstate and the other about 2 miles from the Greenbrier Exit off I-565. Their hushpuppies are to die for.
EdSails Interesting list. I keep telling myself that the next time I go to Fairhope I will spend a day or two in Huntsville to see the space Center. Now I've got some places to eat at. Looking forward to your observations on them.
Foodbme EdSails Interesting list. I keep telling myself that the next time I go to Fairhope I will spend a day or two in Huntsville to see the space Center. Now I've got some places to eat at. Looking forward to your observations on them. It's a pretty good hike from Fairhope to Huntsville. About 5 hours Plus at 75 MPH with 1 potty stop!
buffetbuster Davwud- Just to let you know, I am following this thread with great interest. Last Fall, I spent a weekend in the Huntsville area and came away disappointed with the food. The only place that really grabbed me was Big Bob Gibson's. Hopefully, it was just poor choices on my part and not a dearth of good Roadfood in the area. BTW, despite the food, I thought the area was full of lots to see and do and really nice people.
SassyGritsAL Beauregar's is another great place in H'ville. My son worked there when they opened their first location (Jordan Lane) for five years. Their cheese fries and awesome and a good bologna sandwich. I do agree that they have the best wings in town and I like that you can order all flats if you want (which I do).
Wintahaba ...like raw ground meat.
CajunKing It is amazing that the same family can produce totally different results when it comes to BBQ. The family pie recipes they ALL have down, but the BBQ is the difference tween night and day. Big Bob's BBQ is much better, but Velma and Paul have a good place too.
Davwud At number 8 on the list is Jalapeno Cheddar bread from FredBread.


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American Metalcraft MP1419 14" Round Pressed Pizza Peel with 5" Handle
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Easily move large pizzas, calzones, or even appetizers and sides to and from your oven with this American Metalcraft MP1419 14" round pressed pizza peel.
Because it's less porous, this pressed pizza peel lasts longer and is easier to clean than traditional wooden pizza peels. The American Metalcraft MP1419 pressed wood pizza peel has a tapered, 14" round blade and a 5" long handle. It is made from NSF and USDA Listed material.
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8.17 out of 10 (what is this?)
Press & News
Byrne Robotics: Web Comics. URL Accessed...
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ESkeptic (magazine's Online Newsletter),...
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John L Byrne, age 63
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John has worked for Comics, Comics Writers, Canadian Comics and Canadian Comics Writers.
Andrea Braun Byrne is in John's family.


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Organizations Must Provide Value to Their Members to Survive
Continuing the discussion from the last post where I postulated that ISA and MESA struggle more than IEEE or other engineering organizations in retaining members, in this post I'll offer my take as to why. I already noted that societies that serve specific engineering disciplines like IEEE have a feeder...
Why Do Automation Organizations Struggle Compared to Other Societies
Like many automation engineers I get a steady stream of emails from ISA, MESA and other organizations with announcements about conferences, webinars and white papers. If the volume of email were an indication of viability it would seem that professional societies are alive and healthy.
Network Management Webinar
I recently presented a webinar cosponsored by ISA and CooperBussman's Brian Cunningham on the above topic entitled "Staying Connected – Why Network Management Matters" based on the following abstract:
ISA Automation Week 2012: Innovation in Orlando
I'm not usually much of a Disney fan. The characters from Snow White onward were fantastic, but they were almost always pure good or all bad. Unfortunately, this black-and-white ethos always seemed kind of flat and artificial, like early Superman or DC comics or Lawrence Welk's robotic performers.
Stories You May Have Missed
Some--okay a lot--of folks might say I spend too much time lurking around on Twitter. (www.twitter.com). They're possibly correct. But it's not all time wasted. One of the things that keeps me coming back there with alarming regularity is that the more the number of people I follow increases, the...
ISA Reaches out to Building Automation and Control Group
This just in. ISA has taken a big step toward increasing its scope and significance in the broader world of automation. Read on.
Oil Sands Automation 2012
The ISA Edmonton Section has just finished hosting the 9th annual Oil Sands Automation conference in Fort McMurray and as the tag line on the program states – still the only oil sands focused conference hosted in the oil sands.
ISA Industrial Communications Symposia
Deadlines for the ISA Communications Division two Spring Symposia are quickly approaching. The first event this April in Troy (Detroit) Michigan is a joint offering with the ISA100 WG16 committee that will be two half-days focused on Wireless applications in the Factory environment.
ISA Honors Its Authors
This just in: Research Triangle Park, N.C. -- The International Society of Automation (ISA) has recognized some of its outstanding authors at a ceremony and reception on October 18 at ISA Automation Week in Mobile, Ala. The awards are given by the ISA Publications Department and Standards and Practices Department.
ISA Automation Week Wireless Track Sessions
Brad Carlberg, who chaired this year's Wireless track at Automation Week in Mobile also recorded all the sessions as well so you are now able to get the benefit of both presenter and presentation at the following link http://www.isa.org/~pupid/ISA_AW2011_Sessions.htm


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ordering and delivery are second to none!
Review by confirmed purchaser
Ordering is easy, processing and delivery of order are exceptional. Have had some problems with remanufactured cartridges in the past. hope this batch is OK, but still exceptional value for money. Simple, quick, cheap, what more is there to say?


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Open AccessThis article is
- freely available
- re-usable
Algorithms 2013, 6(3), 546-564; doi:10.3390/a6030546
Quantitative Trait Loci Mapping Problem: An Extinction-Based Multi-Objective Evolutionary Algorithm Approach
Department of Computer Science, Utah State University, Logan, UT 84341, USA
Department of Computer Engineering, Shahid Bahonar University of Kerman, Kerman 76169-14111, Iran
Department of Animal Science, Shahid Bahonar University of Kerman, Kerman 76169-14111, Iran
Institute for Systems Biology, Seattle, WA 98109, USA
Synthetic Biomanufacturing Institute, Logan, UT 84322, USA
* Author to whom correspondence should be addressed.
Received: 28 May 2013; in revised form: 9 August 2013 / Accepted: 26 August 2013 / Published: 2 September 2013
Download PDF Full-Text [424 KB, uploaded 2 September 2013 09:18 CEST]
Abstract: The Quantitative Trait Loci (QTL) mapping problem aims to identify regions in the genome that are linked to phenotypic features of the developed organism that vary in degree. It is a principle step in determining targets for further genetic analysis and is key in decoding the role of specific genes that control quantitative traits within species. Applications include identifying genetic causes of disease, optimization of cross-breeding for desired traits and understanding trait diversity in populations. In this paper a new multi-objective evolutionary algorithm (MOEA) method is introduced and is shown to increase the accuracy of QTL mapping identification for both independent and epistatic loci interactions. The MOEA method optimizes over the space of possible partial least squares (PLS) regression QTL models and considers the conflicting objectives of model simplicity versus model accuracy. By optimizing for minimal model complexity, MOEA has the advantage of solving the over-fitting problem of conventional PLS models. The effectiveness of the method is confirmed by comparing the new method with Bayesian Interval Mapping approaches over a series of test cases where the optimal solutions are known. This approach can be applied to many problems that arise in analysis of genomic data sets where the number of features far exceeds the number of observations and where features can be highly correlated.
Keywords: QTL; quantitative trait loci mapping; multi-objective evolutionary algorithm; partial least squares; extinction-based EAs
Article Statistics
Click here to load and display the download statistics.Cite This Article
MDPI and ACS Style
Ghaffarizadeh, A.; Eftekhari, M.; Esmailizadeh, A.K.; Flann, N.S. Quantitative Trait Loci Mapping Problem: An Extinction-Based Multi-Objective Evolutionary Algorithm Approach. Algorithms 2013, 6, 546-564.
AMA StyleGhaffarizadeh A, Eftekhari M, Esmailizadeh AK, Flann NS. Quantitative Trait Loci Mapping Problem: An Extinction-Based Multi-Objective Evolutionary Algorithm Approach. Algorithms. 2013; 6(3):546-564.
Chicago/Turabian StyleGhaffarizadeh, Ahmadreza; Eftekhari, Mehdi; Esmailizadeh, Ali K.; Flann, Nicholas S. 2013. "Quantitative Trait Loci Mapping Problem: An Extinction-Based Multi-Objective Evolutionary Algorithm Approach." Algorithms 6, no. 3: 546-564.
Published by MDPI AG, Basel, Switzerland
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There are currently 2 reviews out for the game, if you find a review that I have missed, or if you have made a review yourself, post on this thred or PM me to add it to this list.
Reviews So far:
Touch Arcade
According to 1Up imuse has been entirely removed from the game, even from classic mode! Not to mention part of the ending cut off and the inability to switch to classic mode in the intro-much like the original SE.
EDIT: Noticed that much of this is being discussed on the main MI2:SE thread. Mods, you can lock this if you wish.


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I absolutely love these flowers. There are 2 sizes (3/4" to 1-1/4") and 2 shapes of flowers in this collection. They are made of a very strong paper, the texture is realistic (kinda dried looking), and the tye-dye colors make these flowers look like you colored them yourself. Each one is unique!!!!
Used in this layout: NOTHING IS WORTH MORE THAN THIS DAY
You will not be disappointed with these flowers!!! These handmade beauties are worth the money!!! The colors are vibrant and the bling matches them perfectly. I used glue dots to adhere them to the page!!! I am going to purchase them in dofferent colors!!!
Used in this layout: NOTHING IS WORTH MORE THAN THIS DAY


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Posted April 04, 2013 on
AP on Fox
The Baltimore Ravens have terminated the contract of reserve linebacker Brendon Ayanbadejo, a three-time Pro Bowler on special teams.
Ayanbadejo has played 10 seasons in the NFL, the last five with Baltimore. He started four games at linebacker for the Ravens, but his main contribution was on special teams.
General manager Ozzie Newsome announced the move Thursday.
Ayanbadejo has been an open proponent for gay marriage, a stance he reiterated in the days leading up to the Super Bowl.
The 36-year-old Ayanbadejo had a career-high 30 tackles from scrimmage last season for the Super Bowl champions. He also had a sack and 14 stops on special teams.
He made the Pro Bowl on special teams in 2006, 2007 and 2008.
Ayanbadejo started his career with Miami in 2003.
Original Story:
Brendon Ayanbadejo says Ravens cut him over age not views on gay rights
Brendon Ayanbadejo believes his gay rights activism led to him being cut
Ayanbadejo hints at big announcement
Brendon Ayanbadejo, recently released by the Ravens, said that there have been discussions about four NFL players coming out together at the same time.
Brendon Ayanbadejo Says Four Gay NFL Players Could Come Out At Same Time
Ex Ravens LB Ayanbadejo talks equality in South FL
Brendon Ayanbadejo Backtracks on Saying Ravens Cut Him For Gay Rights Stance
Report: Four Gay NFL Players Could Come Out At Same Time
Four Gay NFL players might come out together
Brendon Ayanbadejo Says Groundwork Being Laid for Up to Four Gay NFL Players to Come Out
Ravens release Ayanabejo
Former Raven sees gays in NFL coming out
When one thinks Gay Rights Pioneer, one thinks Mike Francesa
NFL Forum Discussions
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I generally do short, intense cardio sessions (20-25 minutes). I only have a 20 oz shaker, but I've been drinking 6 scoops with 20 oz during cardio. It seems like too much. Is 4 scoops is sufficient?
Also, would it have the same effect splitting the dose pre and post instead of intra? The only reason being that it's an incredible pain in the ass to take gulps from a water bottle while you're in the middle of an exhausting cardio session.
Reps for replies
Thread: How much Xtend for cardio?


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Hotel Playa de Cortes
Travel Blogs from Guaymas
Trains,planes, automobiles and boats..
...to start with we have the weekend to go, then fly home. weep ,weep.
This last week has been jam packed with adventure, otherwise known as bad planning. To cut the story shortish, we didn't get the camper into the next state, so we had to go back 100km and hire a car, then we forgot to change our clocks (from Sonora state to Sinoloa it' …
Mexico is no peligroso
... at all. People are the same where ever you go. There are always bad areas...but if you are not a cocaine sniffing, drug dealing pimp.... you won't go there.
We are in an RV park in San Carlos and just spent 2 hours in the pool with the locals. It was fun speaking "Spanish" with them. They understood us enough to have a good conversation. What I understood loud and clear was, " Porque no tienen los ...
Return to the sea ...
... for my long coach journey into Mexico, but the airport was closing and all i could get was a cheese and ham sandwich that consisted of what looked like half a pig and processed cheese and too big to even get my chops around!No problem, it lasted me the whole 10 hour trip.
Finalamente, I took a taxi to the bus station and waited two hours for the late night bus,as this one probably had a fridge that worked , though they couldn't promise .
The ticket ...
We made it home
... insurance, then we get a sticker to put on her window. With our visitor permits bought and paid for we go back, get our passports stamped, and our on our way.
We arrived at the campground here in San Carlos about 5pm. After a quick set up, it was off to patrol the beach with Kona. It did not take him long to hit the water. We walked a kilometer or so up the beach, then came back on the road, and found a nice ...
Launch Time!
I know it sounds sad ,but I got a signal on my SSB radio today.I was so excited ,even through the crackles and the wake of the fishermen as they motored past in their pangas. Well, what it really means more seriously, is that we can get get the weather every day ,no matter where we are. It seems there's a front coming in in California (Ii saw the signs with the cirrus cloud this morning ) which bodes badly for our departure.However, now we've launched i ...
was perfecto, plus able to use fab facilities, decor and amazing views out to the Sea of Cortez
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.


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This page contains Mega Man 9 Hints for Nintendo Wii called "Hornet Man stage: Unlimited screws" and has been posted or updated on Apr 21, 2009 by tabithaLeila. Let us know what you think of this Hint by thumbs voting.
- Developer: Inti
- Publisher: Capcom
- Genre: Action Platformer 2D
- Release Date: Sep 22, 2008
- ESRB: Everyone
Hornet Man stage: Unlimited screws
You will need the Jewel Satellite in order to do this trick. In the beggining of Hornet Man's stage, move to the right until you reach the first ladder. Without destroying the potted plant robots, activate the shield and stand on the second platform in between both the robots. If you remain standing there, the missiles will be destroyed and the screws will automatically land on Mega Man. This also increase your kill count for your achievements.
Back to all Cheats
Stuck on this game? Set a specific, clearly defined question and let others answer your question or view answers to previously asked questions. If you think you are an Mega Man 9 expert then please try to help others with their questions.
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Vocal Range – Tenor
Singing – Musical Theater, Pop
Dancing – Jazz, Tap
Languages – American English
Height – 6 feet 1 inches / 185 cm
Hair – Brown
Eyes – Brown
Body Type – Athletic
Ethnicity – White/Caucasian
Hey Guys,
I've been doing theatre for about 10 years now up and down California. I'm currently living in LA auditioning, but am moving to NY sometime in the future. I've played everything from Italian meatheads to 12 yr olds going through puberty to Disn...
(Click on a show's title to learn more)
Jersey Boys – Jersey Boys is the inspiring story of four blue-collar boys from Jersey who become the one of the bi...
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Sammy - Wedding Singer
Frankie Valli
none publically displayed.
You must be friends with Nick to leave testimonials!


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Serial Cards & Adapters
If you're looking for a simple, cost-effective way to connect serial devices in your industrial application or server room, our Serial Cards and Adapters make it easy to add Serial ports (RS-232, RS-422, RS-485 etc.) to your computer through common expansion ports such as PCI and PCI Express, as well as through USB.
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Add two RS232 Serial Ports, and one Parallel Port to an Embedded System, through a mini PCI-Express Slot74,99 € exc VAT
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text:
It seems that you're using an outdated browser. Some things may not work as they should (or don't work at all).
We suggest you upgrade newer and better browser like: Chrome, Firefox, Internet Explorer or Opera
pykman says: Original version: ScummVM so no problem. DC: Game runs fine, but I didn't completed it yet.
pykman says: DosBox: Works fine. Note: Police Station Puzzle: Set DosBox cycles to fixed 20000 for proper game speed. Using cycles auto or max can cause game to run too fast.
pykman says: Played with and without unofficial High Resolution Patch. Occasionally crashes, game is completable. Tested on compatibility mode: Win 98/ME
pykman says: Game somethimes crashes with an error, but this is rather rare case. However ther is a bug near the end of the game that crashes it constantly, but it can by bypassed so game is completable. Tested on compatibility mode: Win 98/ME
pykman says: KQ7: DosBox so no problem. KQ8: Occasionally crashes, but game is completable.Tested with compatibility mode: Win 98/ME. dgVoodoo glide wrapper works quite smoothly.
pykman says: I'm running them with ScummVM instead of DosBox and no problem noticed.
pykman says: SQ4: Scummvm. no problems. SQ5: Scummvm 1.5.0 and 1.6.0 crashes on one of the death scenes, no other problems. SQ6: DosBox: sometimes crashes on loading save.
pykman says: Parts 1-3 on ScummVM: no problem. Part 4 DosBox: no problem. Part 5 also completable.
pykman says: LSL1-6 played on ScummVM: no problems. LSL6 SVGA and Softporn Adventure runs on DosBox: no problem
pykman says: Game sometimes freezes (only alt+F4 works). I have to set compatybility mode to Windows XP (Service Pack 3) to see game intro.
Treat your GOGmix as your child - name it! ;)
Coming up with a cool and descriptive title should be your first priority. Being original is in your best interest - bet you wanna get lots of nice votes, right? Go all crazy if you want, but be sure to keep it civil!
So, what are the ingredients?
Pick a game that belongs in your GOGmix from the list, or find it by typing something in the text field. Relevance is key here - Earthworm Jim doesn't quite fit the "Sexiest heroines of all time" bill now, does it?
Justify your choice... Or not!
OK, so it's not required, but now that you went through the trouble of adding a game, telling everyone why you did it would be a nice finishing touch. After you're done here, add another game, rinse, repeat.


text:
Monday, November 02, 2009
George Soros, King of all Liberals, Warns Of China's New World Order
The Leftist billionaire financier responsible for funding major liberal blogs, the Democrat majority in Congress (Soros banked Al Franken's stolen senatorial election recount win in Minnesota this year) as well as Barack Obama's campaign for President, says that China's economy will grow faster than people expect and so will its global economic influence. Whew! Either way when this tyrant speaks you'd better listen.
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Verse1: E Well the midnight headlight find you on a rainy night A steep grade up ahead slow me down makin no time E gotta keep rollin those windshield wipers slappin out a tempo A keepin perfect rhythm with the song on the radio E gotta keep rolling Chorus: E D A E Ooh I'm driving my life away, looking for a better way, for me E D A E ooh I'm driving my life away, looking for a sunny day Verse2: Well the truck stop cutie comin' on to me tried to talk me into a ride said I wouldn't be sorry but she was just a baby well waitress pour me another cup of coffee pop me down jack me up shoot me out headin down the highway lookin for the morning [CHORUS] [VERSE1] [CHORUS] Comments
Popular Eddie Rabbitt tabs & chords Song lyrics. Eddie Rabbitt lyrics
↑ Back to top | Tablatures and chords are parodies/interpretations of the original songs. You may use it for private study, scholarship, research or language learning purposes only |


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He then decides to rip the song himself saying it's "one of my worst songs ever".
You'll understand once you watch this:
Winter Ain't Over Yet
Jimmy Kimmel Asks the People of Austin, Texas if They're ...
Pretty Sure She's Not Under Anyone's Radar
18 Unlucky Moments With Lucky Animals
Now You See This Pool, and Now You Don't!
Wake Up Ritual
Target's Photoshop Disaster Accidentally Makes Crotchless ...
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This video's like the Space Core: OUTTA THIS WORLD.
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Once again, this is a triumph.
Escaping the Sarlaac was a triumph.
Robots singing just like on the radio!
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John Spencer
On this page you'll find links to movies starring or directed by John Spencer. This data is provided by Freebase, so if you see any incorrect information please change it on their site.
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Presumed Innocent 1990 |
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Our Streets • Our Bridge • Our Bayfront • Our Downtown • Our Growth • Join us!
about time. corpus finally made a good move.
lol!! who would buy these chairs and why? funny.
Good for you Marc! Corpus was lucky to have you!
Ignore all these negative CC people who are stuck in that forsaken city! CC people, when are you going to learn, municipal buildings LOSE money! Unless you are a high destination city, WHICH YOUR NOT!
Marc, Come back to San Antonio where people are happy and good times are plenty.
Good times await!
Q: Why is Corpus one of the most dreadful places in Texas and the country?
A: The older demographic and nay-sayers have been the anchors to progression. You would think they would be more active in trying to keep the young talent and children in their city.
CONGRATULATIONS CORPUS, once again you have succeeded becoming well known for being unwelcoming to business and stakeholders. At least your consistent!
I thank GOD everyday that I no longer live in that city. I could no longer bare it.
Its to bad, because that city could be decent. I use to think it could be GREAT, but who are we kidding.
wow, I cant believe corpus is still debating this. its really sad to see corpus is still asleep.
Who shot the video that launched her??????Answer: Dept13filmsNo even mentioned on the article.
Best real estate corpus has, and it cant decide on what to do with it. its simply SAD!! Corpus needs to be more welcoming to the new blood (people from outside of cc), they are the ones that will change this city.
Does everyone understand that municpal buildings LOOSE money, from my understanding only a handful of these buildings in the US make a profit (Vegas, Hawaii, etc).
Hired management companies (i.e. SMG) get paid to help reduce that lost. They get a management fee, thats it! They "SMG"don't get a peice of the parking, tickets, etc. WE DO, the tax payer. The more money ABC makes, the less it looses, and the less we pay in taxes.
Having the MC renovated makes no sense for Corpus. It sits on the best real estate the city has to offer, why Corpus doesnt play this card is beyond me. Make the area attractive for visitors with $$. Because lets face it local citizens dont have the $$.
Corpus has so much potential!!!! It seems like it will be another 15 years before it decided to take that road of potential.
Having the MC renovated makes no sense for Corpus. It sits on the best real estate the city has to offer, why Corpus doesnt play this card is beyond me.
Doug Frank should get Salesman of the Year! I've never seen anyone run an organization like he does. WOW!
Go Corpus YOU ROCK!!!!
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red MX-5500 price labeller plus 10000 labels
brand new MX-5500 pricing gun,still in box. ink already installed inside, and comes with one spare ink. 8 digits high quality and easy to use. size: 23cm x 6cm x 13cm color may vary 10000 labels are included in this auction, as per photo. label size: 21mm x 12mm please have a look at my other listings, many fantastic products with very very surprisingly low reserve!…
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Sister Boom Boom
Sister Boom Boom, was the drag nun persona of astrologer Jack Fertig (February 21, 1955 – August 5, 2012[1]), a retired member of the Sisters of Perpetual Indulgence.[2][3]
Fertig was born in Chicago, Illinois. Often erroneously credited as a founder of the group, Sister Boom Boom actually joined the Sisters in 1980, several months after its founding. She left the order in the Spring of 1986. Her full name was Sister Rose of the Bloody Stains of the Sacred Robes of Jesus, which would trail into a sing-song cadence and a long fermata. This called for a short nickname.[4]
In 1982, Sister Boom Boom ran for a seat on the San Francisco Board of Supervisors with agitprop campaigning tactics bringing humor and raising issues she felt were being ignored in the race. She won 23,124 votes with her occupation listed as "Nun of the Above". Five supervisors were elected; she placed eighth.[5] After she started campaigning for mayor in 1983 against incumbent Dianne Feinstein, San Francisco passed an ordinance requiring candidates to use only their legal names on the ballot. This was commonly called the "Sister Boom Boom law".[2]
Boom Boom wrote a theatrical-ritual exorcism of Jerry Falwell and Phyllis Schlafly performed in Union Square on July 13, the Friday before the 1984 Democratic National Convention before a crowd of 2,000.[6] She is one of the characters in Emily Mann's play Execution of Justice about the trial of Dan White for the 1978 Moscone–Milk assassinations. George Moscone was mayor of San Francisco and Harvey Milk was the city's first openly gay supervisor.[7] In the Broadway production she was played by Wesley Snipes.[8]
Jack Fertig retired Sister Boom Boom in 1985, and joined a sobriety program.[3] Born to a Jewish father and a Christian mother,[9] he converted to Islam in 2003. He worked as an astrologer[10] until his death in San Francisco, California, from liver cancer on August 5, 2012.
- ^ /Users/bjorndk/Desktop/jack fertig 2.jpg Dana Sitar, SF Weekly blog (August 7, 2012)
- ^ a b "Boom Town: San Francisco Cracks Down". Time Magazine. April 11, 1983. Retrieved 13 April 2012.
- ^ a b Bizjak, Tony (November 11, 1989). "When Sister Boom Boom sobered up he vanished from San Francisco Streets". Anchorage Daily News, reprinted from San Francisco Chronicle. Retrieved 13 April 2012.
- ^ http://www.telegraph.co.uk/news/obituaries/9478289/Jack-Fertig.html
- ^ Moritz, Michael; Dick Thompson,William R. Doerner (July 16, 1984). "What's Happening off the Floor". Time Magazine. Retrieved 2009-04-09. "Sister Boom Boom. No large gathering in San Francisco's homosexual community, including the gay rights march planned for the day before the convention opens, would be quite complete without the appearance of a figure clad in a hiked-up nun's habit, black fishnet stockings, and a tightly drawn wimple that sometimes fails to hold in an unruly shock of red hair. These have become the transvestite trademarks of Sister Boom Boom, member of the Order of Perpetual Indulgence, and the drag creation of a 29-year-old astrologer named Jack Fertig. Part put-on artist and part self-promoter, Boom Boom sparks reactions that run the gamut from righteous outrage to raucous approbation. Outside San Francisco, Fertig's bizarre alter ego has come to symbolize a climate of tolerance gone haywire. Boom Boom's "order," which consists of about 20 other "nuns" who go by names like Sister Mary Media and Sister Sadie Sadie Rabbi Lady, has performed legitimate charity work by raising funds for AIDS victims and gay Cuban refugees. Fertig ran for the board of supervisors in 1982; with five seats open, he placed a respectable eighth, collecting 23,124 votes. Even some gays find it offensive when he wears a cross as part of his costume or mocks the sacred. But Fertig insists that he is genuinely, if not conventionally, pious. "The sisters share my own sense of absurdist theater," he says. "I believe that you can reach God through your own means.""
- ^ Shilts, Randy (November 27, 2007). And the Band Played On: Politics, People, and the AIDS Epidemic. St. Martin's Griffin. p. 660. ASIN B000V761ZA.
- ^ Nolte, Carl (2003-11-26). "City Hall Slayings, 25 Years Later: Revisiting the horror of that day of death; for those who are old enough, the memory is searing". San Francisco Chronicle. Retrieved 13 April 2012.
- ^ Gussow, Mel (1986-03-14). "Stage: Emily Mann's 'Execution of Justice'". The New York Times. Retrieved 13 April 2012.
- ^ http://www.sfgate.com/entertainment/garchik/article/Taking-it-all-off-in-San-Francisco-3773485.php
- ^ Smillie, Dirk (2008). Falwell Inc.: Inside a Religious, Political, Educational, and Business Empire. Macmillan. p. 146. ISBN 978-0-312-37629-1. Retrieved 2009-04-09. "Fertig converted to Islam in 2001, and now works as an astrologer in San Francisco."
External links[edit]
- 1955 births
- 2012 deaths
- American activists
- American astrologers
- American Muslims
- Cancer deaths in California
- Converts to Islam
- California politicians
- Deaths from liver cancer
- Drag queens
- LGBT history in San Francisco, California
- LGBT Muslims
- LGBT entertainers from the United States
- LGBT people from Illinois
- LGBT rights activists from the United States
- Muslims of Jewish descent
- People from Chicago, Illinois
- People from San Francisco, California


text:
Nadya Suleman gets a financial intervention from money expert Suze Orman.
Read the afterword from Beautiful Boy: A Father's Journey Through His Son's Meth Addiction by David Sheff.
Use Suze Orman's guidelines to stage a money intervention with a loved one and get them back on sound financial footing.
It's Oprah's first shoe, purse and accessory intervention! Style experts Joe Zee, Adam Glassman and Mary Alice Stephenson help women find the right accessories for their shapes.


text:
Breakstone, White & Gluck, P.C.
2 Center Plaza
Suite 530
Boston, MA 02108
I am a trial lawyer in Boston, Massachusetts, where I concentrate my practice in personal injury, insurance company bad faith, bicycle accidents, construction accidents, and professional liability litigation, primarily for plaintiffs. I also represents businesses in litigation, and represents attorneys in partnership disputes and other professional matters. My goal is to provide the best service...
Show more30% | Personal Injury | 30 years |
25% | Car / Auto Accident | 30 years |
20% | Brain Injury | 30 years |
15% | Defective / Dangerous Products | 30 years |
10% | Wrongful Death | 30 years |
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Posted by: a client 6 months ago.
From my first phone conversation with David (who insisted I call him David), I was sold that he was the right lawyer for my husband and I. Having...
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I endorse this lawyer. David's tenacity with a case is amazing. He leaves no stone unturned, he fights like a mother bear for his clients, and he...
Boston, MA
Relationship: Fellow lawyer in community
I endorse this lawyer.
Massachusetts Superior Court
1984 JD - Juris Doctor in Law
Northeastern University School of Law
2008 President's Award
Massachusetts Assoc. of Criminal Defense Lawyers
2006- present Member
American Bar Association
2008 Handling Anesthesia Malpractice Cases
2011 Pre-Suit Evaluation and Handling of G.L. c. 93A and c. 176D Claims
2010 Starting Your Own Law Practice


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Share your comments
Angels flight [sound recording]
Michael Connelly
Adult Fiction CONNELL
Michael Connelly
Adult Fiction CONNELL
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nitetrain said:
There are a few good Harry Bosch novels, but this isn't one of them. It's never a good sign when you know what the author is going to write before you read or hear it. This tale written after the OJ trial is not one of Connelly's best at all. 2 of 10 stars.
posted Mar 18, 2009 at 11:00PM
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Harry (Hieronymous) Bosch
Homicide detective
Howard Elias
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Wordle Up
Raquel, mi querida co-editor, was recently in Puerto Rico to talk Reggaeton. Among a variety of venues, she also ended up on video –
While watching I was surprised to see, suddenly in the mix, a wordle I made from my chapter in the book. A fitting backdrop, sin duda –
Have you read it yet? It may be my best piece to date. Just sayin.
4 Comments Add your own
1. dave quam | May 18th, 2009 at 2:48 pm
i just got a gift certificate to amazon, ordering that right now
the cover is SO GOOD
2. Rob Tuck | May 24th, 2009 at 7:50 am
I'm determined to get my library (Exeter, Devon) to get this book on the shelves before I graduate.
Shame it wasn't out a couple a months ago when I began my diss!
3. wayneandwax.com » C&hellip | June 22nd, 2009 at 2:10 pm
[...] Even without an explicit dembow in the more recent productions (by the same people who produced hits during reggaeton's heyday, to date), there's still a recognizable aesthetic core there, I'd argue — one that emerges precisely out of the PR-based engagement with US and Caribbean and Latin American dance/pop/rap. You might miss it if it's dembow orthodoxy you're searching for (and I may be as guilty as any in pointing people to keep their ears on the snares). I could go on in some detail and elaborate, but, you know what, I already have. If you're interested in this aesthetic history (and the role different genre names and forms have played), READ MY CHAPTER ALREADY. [...]
4. Negrita | July 7th, 2010 at 12:14 am
This book is really important and sheds light to a genre that needs to be documented while its still fresh. It to me back to 1995 when I first listened to Playero 37, 38, etc. I'm currently interested in writing my master's thesis on this subject. I really appreciate a book like this.
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From Ego to Eco: a short video introduction to the event in Sao Paulo Nov 5 2012
If you are in Sao Paulo Nov 5, please be sure to join me for this event. The video below outlines some of the topics I am planning to talk about. See you there!
If you are in Sao Paulo Nov 5, please be sure to join me for this event. The video below outlines some of the topics I am planning to talk about. See you there!
BIG ANNOUNCEMENT to my Brazilian friends and tweeps: please join Gerd on November 5 2012 for this very promising event at the Museum of Sound in Sao Paulo, organized by Gilson Schwartz and Joe Tripician in Sao Paulo
Do Ego ao Eco ao Ícone. Rumo ao futuro sustentável pela economia criativa com Gerd Leonhard Dia 5 de novembro das 9h às 12 horas ao Museu da Imagem e Som, São Paulo. Participação de Davi Nakano (POLI-USP) e Gilson Schwartz (ECA-USP). Qual a relação entre economia verde, inovação tecnológica e novas mídias.
Data: Dia 5 de novembro das 9h às 12 horas
Local: Museu da Imagem e Som - Avenida Europa, 158, Jardim Europa, São Paulo - SP, Brasil
Informações: firstname.lastname@example.com
Register here (150 Reals)
Find out more about Gerd's Ego to Eco meme
Also speaking with me are:
Davi Nakano: Professor Doutor da Escola Politécnica-USP
Revisor do International Journal of Production Economics
Especialista em Economia Criativa e Gestão do Conhecimento.
Gilson Schwartz: Programa de Pós-Graduação em Meios e Processos Audiovisuais (PPGMPA-USP)
Programa Interdisciplinar de Pós-Graduação Humanidades, Direitos e Outras Legitimidades (FFLCH-USP) Grupo de Pesquisa Cidade do Conhecimento.
Here is the complete video from my March 24 keynote at EcoSummit 2012 in Berlin (http://ecosummit.net/) speaking on "the journey from Ego to Eco", see the slideshow here (slideshare); also embedded below. More on the Ego To Eco topic can be found here.
It would be great to get your feedback on my key messages on this fairly new topic, and also on the new slide design I am now using. Thanks!!
This is precisely where technology and energy issues intersect. Brilliant. Reading his book right now, btw.
Jeremy Rifkin: Energy-sharing is the new internet (Wired UK)
"The TIR will lay the foundations for a collaborative age. Its completion will signal the end of a 200-year commercial saga characterised by industrious thinking, entrepreneurial markets and mass workforces, and the beginning of a new era marked by collaborative behaviour, social networks and boutique professional and technical workforces. In the coming half-century, conventional, centralised business operations will be increasingly subsumed by the distributed business practices of the TIR; and the traditional, hierarchical organisation of power will give way to lateral power organised nodally across society..."
PS: also be sure to read Collaborative Consumption by Rachel Botsman
i.mediafuturist.com for mobile updates


text:
Your Current Weapon (Guitar)
I was wondering what everyone here is currently using, thought it would be fun for everyone to share what guitar(s) they have.
I own a RG370DX, love the guitar to death. I don't give a crap what others say, Edge Pro II is a really nice tremelo, makes life easy and its so easy to mute on it. Neck feels like your runnin through butter hehe. -/Gamma |
jackson warrior usa 1
theres probably something already on this, but anyway. i play a BC rich warlock, platinum series. standard BC pick-ups, ernie ball .12 gauge strings. it's not the most special of guitars, but i like it's look, it plays very nicely and the sound gets the job done. i wouldn't mind upgrading though, but thats for the future.
dean 450 custom tiger eye
ESP LTD EC-1000, They are great for the price, The EMG's do their job and then some, most "metallers" use them but they really dominate in any style. Not as good as a custom shop ESP or at least not as expensive. That's the main guitar anyways.
A Jackson RX10D
BC Rich custom icup10bc8ukas5-myxmg relic vintage triple platinum bronze war hero unsigned artist special signature series custom copy with three strap locks |
jackson king-v with an x2n in bridge and paf pro in neck
i need new pickup rings for it though... |
how much did you buy that for and are they still available i have been looking for one of them. what store did you get it from. :beer: |
i have a bheringer vtone :(
i think he got it from ebay(?) |
ESP LTD MH-250NT in Dark Brown Sunburst tuned in C
Jackson WRXT Warrior in Transparent Red in standard tuning Both rocks for the price.. :flame: :vampire: In a near future, a EMG 81/89 combo for both axe |
oh cool i'll have a look now :beer: |
PRS McCarty Hollowbody II+
Samick UM-3 I also occasionally use a fender strat that I put a Floyd Rose on. |
USA Jackson reverse, 22 fret, Seymour Duncan PU's, Licensed Floyd Rose.
bastard got a pick of it?? |
late 80's kramer pacer with dimarzio tone zone at bridge :love:
edit: it has a barrel jack which is absolutely shagged...in need of a new one real soon! |
a customized esp explorer with extended neck,Reversed Head, kahler tremelo, emg 81-89 setup. .013 strings tuned to Bb
Jackson RR-3 with seymour duncans, licenced floyd rose tuned to C Ibanez Rg2570e with dimarzio's, Edge pro bridge tuned to E :beer: |
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In this technological age, everyone has a cellphone, and everyone knows just how annoying cellphones can be. Because of this, July is Cellphone Courtesy Month! Don't laugh, it's real. Thanks to Cellphone Courtesy Month, we present to you celeb …
These Hot Boys Will Make Your Day – The Berry | |
Chris Evan's Heart-to-Heart Moment – Lainey Gossip | |
We Can Hardly Handle The Hotness – The Berry | |
Neville Longbottom Continues To Make Us Drool – Lainey Gossip | |
Cuteness Overload: 32 GIFs That Will Make You Awwwww – The Berry | |
Jared Leto Proves That He's Still Sexy – Lainey Gossip |


text:
Al Jackson was a money drummer. Literally. He got his characteristic snare sound by loosening the snares and placing his billfold on the head. Part rock and roll, part blues, all rhythm, Jackson created the pocket that made radio rockets out of anyone lucky enough to record with him. Listen to any Al Jackson recording and you'll truly understand what the word "feel" means.
Born in Memphis in 1934, Jackson was a child prodigy, performing with his father's big band at the tender age of five. In 1962 he joined keyboardist Booker T. Jones, guitarist Steve Cropper, and bassist Duck Dunn in the Stax house band. They made musical history as Booker T. & The MGs, powering hits by Wilson Pickett ("Midnight Hour"), Otis Redding, Rufus Thomas ("Walking The Dog") Eddie Floyd ("Knock On Wood") Sam & Dave, and scoring their own instrumental hits ("Green Onions"). Though they rarely toured, The MGs made seminal live recordings, such as Otis Redding's performance at Monterey Pop in 1967.
As drummer Jim Payne has said, Al Jackson's "style was powerful, groove-oriented, and deceptively simple." Booker T. himself once complained that he had played the hit "Green Onions" with hundreds of drummers, but none of them nailed the simple groove as well as Al.
The group disbanded in 1971 when Booker T. moved to California, but Jackson was soon working with Eric Clapton, Freddie King, and other greats. An attempted reunion was aborted when Jackson was fatally shot on October 1, 1975.
—Phill Hood
Al Jackson on Wikipedia.
All Jackson on Drummerworld.com.
Funky Drummer
Al Jackson on Funky Drummer.
Stax Records
Al Jackson Stax Records Bio.
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C W Stoneking and John Butler
C W Stoneking is a living embodiment of raw old blues and hillbilly music. John Butler's image is seriously laid-back, but listen to his music and you'll hear another story.
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Broadcast date Tuesday 7th April 2009
C W Stoneking's parents are American but he was born and bred in the top end of Australia. His most recent album, rich with heat, humidity and stories is called Jungle Blues.
John Butler is famous of course for his Trio, but last year released a solo album One Small Step. His solo tour of Europe and the US kicks off in July this year.
You can either listen to each Conversations interview by clicking on the audio (see 'click here ....' underneath the photo on the left) or you can download each interview as a podcast.
To subscribe to the Conversations podcast, paste http://www.abc.net.au/queensland/conversations/conversationspodcast.xml into your podcasting software
Search Conversations
Know a good story teller? They don't have to be famous, just an ordinary person with an extraordinary tale. Send us a suggestion.
Listen to Conversations in these locations.


text:
Updated November 28, 2011
The nominations for the 2011 Soul Train Awards were announced Fri., Oct. 21 and Chris Brown received the most nominations, five. Beyonce was the runner-up with four noms. The show was taped Nov. 17 in Atlanta and aired Nov. 27 on both the BET and Centric cable channels. Cedric The Entertainer hosted, and Jill Scott, Robin Thicke, Lloyd, Miguel, Melanie Fiona and Keith Sweat were among the performers. The full list of nominees and winners in all categories is below, with the winners in bold and an asterisk (*) next to them.
Best Female R&B/Soul Artist
- Marsha Ambrosius
- Beyonce
- Mary J. Blige
- Jennifer Hudson
- Kelly Rowland
- *Jill Scott
Best Male R&B/Soul Artist
- Eric Benet
- Chris Brown
- *Cee-Lo Green
- Miguel
- R. Kelly
- Trey Songz
Best New Artist
- Marsha Ambrosius
- Bruno Mars
- *Miguel
- Frank Ocean
Song of the Year
- "So in Love"
Jill Scott feat. Anthony Hamilton - *"Motivation"
Kelly Rowland feat. Lil Wayne - "Sure Thing"
Miguel - "Rolling in the Deep"
Adele - "She Ain't You"
Chris Brown - "All of the Lights"
Kanye West feat. Rihanna
Centric Award
- Bilal
- Aloe Blacc
- Anthony David
- Ledisi
- Raphael Saadiq
Album of the Year
- Passion, Pain & Pleasure
Trey Songz - 21
Adele - *F.A.M.E.
Chris Brown - The Light of the Sun
Jill Scott - 4
Beyonce - Watch the Throne
Jay-Z/Kanye West
Record of the Year (Songwriter's Award)
- "Rolling in the Deep"
Adele - *"Far Away"
Marsha Ambrosius - "Best Thing I Never Had"
Beyonce - "Good Man"
Raphael Saadiq - "Hold My Hand"
Michael Jackson feat. Akon
Best Dance Performance
- "Motivation"
Kelly Rowland - "Only Girl in the World/"What's My Name"
Rihanna - *"Run the World (Girls)"
Beyonce - "She Ain't You"
Chris Brown - "Walking"
Mary Mary - "Pretty Girl Rock"
Keri Hilson
Best Hip-Hop Song
- *"Moment for Life"
Nicki Minaj - "All of the Lights"
Kanye West feat. Rihanna - "Look at Me Now"
Chris Brown feat. Busta Rhymes & Lil Wayne - "Out of My Head"
Lupe Fiasco - "Otis"
Jay-Z/Kanye West
- "I Smile"
Kirk Franklin - *"Walking"
Mary Mary - "Heaven Hear My Heart"
Trin-I-Tee 5:7 - "I Believe"
James Fortune feat. Shawn McLemore - "More"
Cece Winans
- "Bend Over"
Machel Montano - *"Man Down"
Rihanna - "Delilah"
Movado - "Wotless"
Kes The Band - "Summertime"
Vybz Kartel


text:
The Faculty Grievance Commission is an independent panel composed of three members of the standing faculty holding the rank of professor. These three members serve serially as chair-elect, chair, and past-chair of the commission.
The Faculty Grievance Procedure is available to any member of the standing faculty, standing faculty-clinician-educator, associated faculty, academic support staff, or compensated emeritus faculty at the University of Pennsylvania.
For more information about the Faculty Grievance Procedure please see the Faculty Handbook.
If you would like to discuss a potential grievance, please contact the Chair of the Faculty Grievance Commission:
Martha A. Q. Curley
Ellen and Robert Kapito Professor in Nursing Science
Office: Room 424 Fagin Hall


text:
Written on: 25/07/2003 by Joshua. (1 review written)
The main thing about this Sagem MW 930 is the battery has a short life. My phone keep turning itself off several times a day. Even if it's just been charged. When I turn it on again it could work for a few second or a few hours.
The shape of the handset looks nice, but when your texting you have to hold it in a way that gives your hand a cramp. Also if your not using predictive texting, and you wanted an S you would have to hold the button down for 4 seconds. That makes any text a very slow…
Read Full Review
As rated by real users
" LG Rumor is a great phone! " Read More
" Perhaps the most stylist phone ever " Read More
Written by Winterburn
" A classic mobile " Read More
Written by evanwebb
" I like everthing but i dontif it works " Read More
" Binatone Big Button Mobile Phone is excellent value " Read More


text:
Searched around for the best deals for costume, or at least for the one i wanted and this place were the best and good value for money. They email once your order has been done and then texts you when it has been dispatched, delivered to the post office then tell you when it will be sent to your house. Great service because i knew where my order was and was kept informed every step of the way. Defo using this again and will letting everyone know good it is. Facebook ere i come!
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04 May 2009 | #1 |
| Executing exe files on mapped home server drive Hey guys I'm already asking me a while wether it's possible to deactivate the annoying security warning ("Do you want to run this file") when I run exe files on my samba share. I put various portable apps there and i want to use them as usual files on the local computer. Is that possible? I don't know exactly for what keywords i should search, so i didn't find anything yet. Thanks, best regards, kappen |
My System Specs |
. |
05 May 2009 | #2 |
| There's a couple of things you can do to help this. 1) Right click the file and select Properties. If there's a button called "Unblock" you can click, click it. 2) Go to IE, Internet Options, Security tab, Local Intranet selection. Click Sites and then Advanced. Add the FQDN for your Samba share to that with the addition of *. in front of it. For instance if your share is Samba, you would add *.samba This would cause your computer to fully trust the Samba share. If the programs require admin priviledges, you can disable UAC stuff, but I would recommend against this. |
My System Specs |
06 May 2009 | #3 |
| Thank you. I expected that there is a way like this. I don't want to disable UAC, because i know what it's good for. Thanks & Best regards, kappen |
My System Specs |
. |
06 May 2009 | #4 |
| Did my suggestion fix it for you? I've only used it in a domain environment (with a DFS namespace), so not sure how it would react in a workgroup setting. UAC basically alerts you whenever your computer tries to do something potentially dangerous (like running a program with administrator rights). In Vista, this was horribly annoying. In 7, it's more fine tuned and actually useful now. For the average user who isn't a full on geek with years of experience working in IT, I suggest to leave it on. It'll make you click a couple of extra times on somethings, but in the long run, it'll save you a headace if malicious code actually does get on your computer (or network). |
My System Specs |
06 May 2009 | #5 |
| Yep, it helped. Just entered the servers name there and no problems left. The Full qualified domain name wasnt necessary (though there is no one i guess in a workgroup?^^) I know how UAC works, but thank you again for your answer I like the uac, i can see important actions, where do i need admin rights etc (very similar to the ksudo command in linux) Thanks & Best regards |
My System Specs |
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maha: "everybody gets one weird, artsy, freaky, abstract film to love and call their own. This one's mine, I think. I can't explain it but I feel it..."
maha: "never forget seeing this on the big screen, priviledge to teach a class on it the next day. A great movie for a great moment in my life."
maha: "how many times can I re-watch this? How many hours in a day? Just a masterpiece."
maha: "love to re-watch this. Chaplin's the best, and Criterion does it up right with two discs and a lovely transfer...."
maha: "definitely meant a lot to me at a certain time in my life. Haunting, despairing, severe, and elegant"
maha: "just a fine, fine flick. I'm rooting for both of them, it was a flop after the brilliant success of 400 blows, but holds up magnificently"
maha: "sold on just the first movie alone, rewatch value is strong, too. looking forward to checking out the second film, perhaps after *cough* gardening"
maha: "SO glad they picked this one up. Loved it for years now..."
maha: "mmmmm"
maha: "sort of where it all began....definitely want to re-engage with it"
maha: "the souped-up version, not the Korean knockoff I've got now"
maha: "(ex)pensive and weird, but good"
maha: "just wonderful, fresh, breezy life. A classic, a cornerstone, and you have to love Truffaut's vim and vigor. The redone edition is georgeous, too"


text:
This motel was a bit of a surprise. It was very clean and centrally located. The king suite we were given was a huge room with a semi private balcony overlooking the pool area. The balcony was shared by two king suites. Oddly there was only 1 rocker per room on the balcony. The room was large with a couch,... More
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text:
For as long as we can remember, there's been a distinct -- and quite literal --...
Ahead of the Spanish Grand Prix the weekend of May 12, the struggling HRT Formula One Team gave FIA president Jean Todt a tour of its new factory at the Caja M�gica sports complex in Madrid—a factory that team bosses expect to give the fledgling operation a boost in performance.
HRT, under the leadership of Sa�l Ruiz de Marcos and team principal Luis P�rez-Sala, continues to struggle at the back of the Grand Prix grids but wanted to show Todt and a group of Spanish motorsports officials that its new facilities offer genuine prospects of improvement. The team skipped the recent F1 test session at Mugello—the only one allowed during the season, and therefore critical to teams' car-development programs—to commission the new factory. Todt was suitably impressed.
"I'm happy to have had a great opportunity to visit HRT's beautiful new facilities alongside my friends from the Spanish motorsport federation, the RACE and the RACC," Todt said. "The facilities are impressive, modern and functional. You can see that everything is brand-new, and it will be even better once they've spent a couple of months there working here."
HRT also took the opportunity to announce a new sponsorship deal with Cristalbox, a Spanish car-windshield repair and replacement specialist.
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