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Category Archives: Software Archive
Magazine in movie "WarGames" is discovered using an Internet Archive Collection
An intrepid researcher wanted to figure out what magazine was used in movie WarGames and using the Internet Archive collection found it was Creative Computing. (which was a key magazine for me in the 70′s when I sold … Continue reading
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Microcomputer Software Lives Again, This Time in Your Browser
The miracle is now so commonplace that it's invisible: we have the ability to watch video, listen to music, and read documents right in our browsers. You might get a hankering to hear some old time radio, or classic television programs, … Continue reading
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Archive of Historical Computer Software is here
Thanks to Jason Scott, lots of deep collecting communities, and volunteers, Jason is announcing that the Internet Archive now hosts some very large software and computer documentation collections, maybe the largest overall host. Yippie! Now we all have to make … Continue reading
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Hard Drive Archaeology – And Hackerspaces
Two different, but somewhat related additions to the archive you might want to check out. First, I was contacted earlier this week about a project to recover information off of an old Cray-1 supercomputer hard drive. Unlike, say, trying to … Continue reading
Posted in Cool items, Software Archive
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Time for Wine
The Internet Archive is located in San Francisco, and so to celebrate our proximity to some of the most renowned wine regions in the world, we bring you this entry about our favorite ferment. This entry contains aromas of cedar, … Continue reading
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Union troops in front of the U.S. Capitol
Washington, DC Saturday, August 31, 2013
Kenneth Winkle is a history professor at the University of Nebraska-Lincoln and the author or "Lincoln's Citadel: The Civil War in Washington, DC." In this program, he talks about the transformation of Washington, DC during the Civil War, from a sleepy town with significant pockets of pro-slavery sympathizers, to the bustling nerve center of the Union and a refuge for thousands of freed slaves. The U.S. Capitol Historical Society hosted this event.
Updated: Tuesday, September 3, 2013 at 10:38am (ET)
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Alexandra Lane from the White House Historical Association and Elizabeth Dowling Taylor, author of "A Slave in the White House: Paul Jennings and the Madisons" talk about 19th century African American work and life in Washington, DC, especially in the area around the White House known as President's Park. The event was hosted by the David M. Rubenstein National Center for White House History at Decatur House.
More Info »
The Abraham Lincoln Association celebrated Lincoln's birthday with a special presentation by historian Allen Guelzo of Gettysburg College. Guelzo gave an assessment of the rise, decline--and rise again of the reputation of our sixteenth President.
Historian Michael Burlingame delivers a presentation on Abraham Lincoln and the process by which Lincoln came to embrace the liberation of slaves. His lecture was part of the U.S. Capitol Historical Society's symposium on Emancipation during the Civil War. This program is forty-five minutes.
Author and presidential historian William Seale discusses life in the Lincoln White House – and how the Lincoln family's presence there during wartime reinforced the idea of the White House as the President's official residence. From the Lincoln Forum Symposium in Gettysburg, Pennsylvania.
African Americans living in the nation's capital were freed when Abraham Lincoln signed the District of Columbia Emancipation Act in April 1862, nine months before he issued the Emancipation Proclamation. Kate Masur of Northwestern University spoke about the impact of the law at the U.S. Capitol Historical Society.
Hari Jones of the African American Civil War Memorial and Museum delivers a two-part talk about African American intelligence and espionage efforts on behalf of the Union leading up to and through the war. In part one, he details the pre-existing networks of people of African descent in the United States, and how those "knowledge circles," as he calls them, were the foundations for the "Loyal League," a secret national organization of slaves, servants, and freedmen who contributed to the Union cause, and viewed the Civil War as the ultimate means of ending slavery. In part two, he details the activities and movements of specific African Americans on both sides of the lines during the war. The Historical Society of Washington, DC and the International Spy Museum co-hosted this event.
Museum of the Confederacy guide Michael Thomas talks about the life and military career of Patrick Cleburne. Born and raised in Ireland, Cleburne emigrated to the United States in his early 20s, and settled in Arkansas, where he became a lawyer. He joined a local militia in the lead-up to the Civil War -- and upon Arkansas' secession from the Union -- Cleburne began his rise through the Confederate ranks, eventually earning the rank of major general. The Museum of the Confederacy in Richmond, Virginia hosted this event.
Author and University of Virginia history professor Elizabeth Varon discusses her book, "Appomattox: Victory, Defeat, and Freedom at the End of the Civil War." She talks about the surrender of Confederate General Robert E. Lee to Union General Ulysses S. Grant at Appomattox Court House on April 9th, 1865, and details what she contends are the two generals' differing interpretations of the surrender terms. Ms. Varon argues that the popular romanticized understanding of the surrender as a grand moment of reconciliation conceals the true ideological struggle over the war's causes and meaning. The University of Virginia's Miller Center of Public Affairs hosted this event.
Author and professor Jean Edward Smith discusses the military career of Ulysses S. Grant, from his entry into West Point through his service and leadership of Union forces in the Civil War. He talks about Grant's feelings on military service, his leadership style, and his many successes and failures. The New-York Historical Society hosted this event.
Author Bill Morgan discusses highlights from his book, "The Civil War Lover's Guide to New York City," which considers more than 150 monuments, memorials, forts, graves and other Civil War historical sites in New York City. The Civil War Forum of Metropolitan New York hosted this event.
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text: Claire Danes and Lena Dunham walked the red carpet together at the Time 100 GalaClaire Danes (in Lanvin) and Lena Dunham (in Saint Laurent and Forevermark jewelry) held on tight on the red carpet before the Time 100 Gala in New York. "Lena's power lies largely in her self-awareness and wit," Danes writes about Dunham in the issue. "Like all great comics, she has a joke ready to deflect any jeer."Read MoreLess


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Side Dishes
(10 Recipes) Created by ABIDILLA15
Recipes in this Collection
Very Good 4.3/5
(51 ratings)
A colorful mix of red & sweet potatoes. Submitted by FREETOCHANGE Carbs: 15.8g | Fat: 0.2g | Fiber: 2g | Protein: 1.4g | Calories: 68.8
Yummy asparagus baked with Parmesan and olive oil! Submitted by JITTABUG118 Carbs: 3.8g | Fat: 5.2g | Fiber: 1.8g | Protein: 3.9g | Calories: 69.3
Turn your favorite side dish into something special in just a few minutes. Only five ingredients and packed with flavor, this dish is a winner! Submitted by SPARK_RECIPES Carbs: 29.9g | Fat: 7.2g | Fiber: 2g | Protein: 3.1g | Calories: 195.2
Dress up packaged cornbread with sweet honey-roasted corn and spicy jalapenos. The chipotle-honey butter adds even more flavor for little effort. Submitted by SPARK_RECIPES Carbs: 23.2g | Fat: 14g | Fiber: 1.1g | Protein: 4.1g | Calories: 234.7
Low-fat comfort food in no time flat--with a full serving of veggies. Is there anything better? Submitted by SPARK_RECIPES Carbs: 27.6g | Fat: 2.2g | Fiber: 3.9g | Protein: 10.4g | Calories: 168.6
Finally! A stand-in for condensed cream of mushroom soup without all the fat and salt. This recipe will revolutionize your casseroles. Submitted by SP_STEPF Carbs: 11.1g | Fat: 2g | Fiber: 4.3g | Protein: 5.6g | Calories: 81.2
Lemony coriander and smoky cumin pair perfectly with sharp Cheddar in this grown-up spin on scalloped potatoes. Submitted by SP_STEPF Carbs: 20.9g | Fat: 4.2g | Fiber: 2.7g | Protein: 5.5g | Calories: 139.8
This Southern staple gets a dose of fiber--with half of the fat of the original. Make a double batch over the weekend and freeze for the busy weekday mornings. Submitted by CHEF_MEG Carbs: 13.5g | Fat: 4.2g | Fiber: 1g | Protein: 2.6g | Calories: 104.4
Who said finger food is unhealthy? Submitted by CHEF_MEG Carbs: 3.2g | Fat: 0.7g | Fiber: 0.4g | Protein: 3.5g | Calories: 36.1
We swapped shrimp for crab in this Chinese takeout favorite to save sodium and money, but we didn't skimp on flavor! Submitted by CHEF_MEG Carbs: 11.4g | Fat: 4g | Fiber: 0.2g | Protein: 6.2g | Calories: 108.1


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Man Found Fatally Shot On Kensington Street
By Jenn Bernstein
PHILADELPHIA (CBS) — Police are searching for whoever fatally shot a man in Kensington late Monday evening.
Police say just after 11:30 p.m., a 911 call came into police reporting shots fired.
When officers arrived, they found a male in his early to mid 20's lying on his back in the 3400 block of J Street.
The victim was shot multiple times in the back and the torso. He was pronounced dead at the scene.
"We did find some ballistic evidence around the corner, on Estaugh Street. We believe that's where the shooting may have started. And the victim ran south on J Street where he collapsed," said Chief Inspector Scott Small.
Homicide detectives searched the area and checked for witnesses as they collected potential evidence at the scene.
There is one thing they're hoping will help solve this homicide.
"We did find several businesses in the immediate area with private surveillance cameras, so hopefully they recorded some or all of this incident," said Small.
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Director Bill Condon never gives Benedict Cumberbatch room to act.
There are plenty of good reasons to be scared this Halloween, be it Hurricane Sandy or the economy or JJ Watt (assuming you are an opposing team quarterback), but just in case none of these things hits home with you, geek, I'd like to offer some items that will. Every person who has owned a comput ... More >>
The Business Software Alliance announced last week that it had come to an agreement with local business Affordable Power, LP, to settle legal claims that the company pirated software titles. According to the release: As part of the settlement, Affordable Power agreed to pay $150,000 to settle legal ... More >>
My aunt called me on Tuesday. She just got an iPhone. Admittedly, she is not technically inclined and was in need of a little technical support. Apparently, when she deleted e-mails she received on her computer in Outlook, they still showed up in her inbox on her phone. I diagnosed the problem, but ... More >>
Chip Kelley back when he was answering questionsIn the weeks leading up to the BCS Championship Game between Auburn and Oregon back in January, a lot of the game-related chit-chat centered on the controversy swirling around Auburn and the "pay for play" scheme that Cecil Newton, the father of ... More >>
Earlier this week, the official Top 10 Houston Rap Albums of 2010 list was posted. Though initially the only real surprise on the list seemed to be the discreet Preemo wiggling his way through the thorn bushes all the way up to the No. 2 spot, there were plenty of emails to wade through about ... More >>
Houston's history is dotted with albums that, fairly or not, have been swept aside. We'll examine them here. Have an album that you think nobody knows about but should? Email firstname.lastname@example.com. Killa Kyleon Natural Born Killa (mixtape, 2010) Back in February, Killa Kyleon threw a pictu ... More >>
Today is the late Judy Garland's birthday, and the embattled drug-addicted star of The Wizard Of Oz (plus a whole trove of movies we have never seen), would have been 88 years old. She was one of the first well-documented victims of drug abuse, at least in hushed tones. She was famous for rou ... More >>
"What---what is this salty discharge?....This is horrible! I care!" -- Jerry Seinfeld, wiping away tearsI have to admit, it was a bit of a strange feeling. As time wound down in the third period of what at the time was a 2-1 Canadian lead over the United States Olympic hockey team, the disappo ... More >>
Each Wednesday, Rocks Off arbitrarily appoints one lucky local performer or group "Artist of the Week," bestowing upon them all the fame and grandeur such a lofty title implies. Know a band or artist that isn't awful? Email their particulars to email@example.com. Hi there. Welcome back ... More >>
It's a well-known fact that most band names are essentially gobbledygook, but here at Rocks Off, we're trying hard to decode Houston's oddest monikers in order to find a little meaning. We mean this with affection and sincerity: 10th Gräde Cütie destroys everything they touch and should be booked ... More >>
"Tonight is Latin night, and things are about to get steamy," Tom Bergeron intoned over the opening montage of last night's Dancing With the Stars. Half of that statement is true. This is week three, when the contestants sack up and start showing some real fire, or in the case of Tom "Dazzle ... More >>
"Tonight is Latin night, and things are about to get steamy," Tom Bergeron intoned over the opening montage of last night's Dancing With the Stars. Half of that statement is true. This is week three, when the contestants sack up and start showing some real fire, or in the case of Tom "Dazzle ... More >>
Robert Casey told on Constable Perry Wooten. Wooten fired him. Now Casey and two other people are suing to get their jobs back.
So long to slackers and laid-back lifestyles. Now that cash-rich techies have taken over, can Austin survive the great digital divide?


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If you wound up on this page expecting to read the usual diatribe from "Someone's in the Kitchen," don't worry ~ you haven't clicked the wrong link. It's still the same old me with a whole new look!
Back in 2006 when this blog first started, I was the owner of a catering kitchen and gourmet market called "Wish Upon A Chef." I chose not to saddle the blog with the business name because I wanted a place that was truly mine to vent about customers, employees, and work without anyone associating my rants with them should they happen to stumble across my virtual diary. Eventually I sold the business and the rights to the name but I continued to feel particularly connected to the name and the business itself. I dreamed it. I built it. I worked it. It was my life for seven years.
Unfortunately, my dream did not continue to flourish under new ownership as I had hoped it would, and now there's nothing left but an expired domain name. Thanks to godaddy.com, I was able to reclaim the name and breathe new and different life into my dream. Wish Upon A Chef is who I was, and in alot of ways who I still am.
Welcome home.
The New "Old" Me
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The talented star of "The Motherf**ker With the Hat" shows off her backstage digs.
April 14, 2011In Cat On a Hot Tin Roof, Emily Bergl may play the greedy Mae Pollitt, but offstage, she's an art-loving, disco ball-collecting, tea-making and robe-wearing Broadway sweetheart. Check out her cozy backstage home at the Richard Rodgers Theatre!
January 9, 2013
The handsome actor shares his backstage must-have items.
November 2, 2011The actor shares his five favorite dressing room items.
April 18, 2012When she's not being motherly in Picnic, Mare Winningham has plenty of family keepsakes in her dressing room to remind her of home, including her beloved guitar, a memoir written by her mom and a pic of her grandma (who looks just like Mare!).
February 6, 2013The actor shows off five of his essential dressing room items.
November 29, 2011In Chaplin, Wayne Alan Wilcox may play Charlie's pragmatic brother Sydney, but offstage, he's an art-loving, ginger tea-toting cheerleader for his Broadway castmates. Check out his cozy backstage home at the Barrymore Theatre!
September 26, 2012The leading man reveals five favorite dressing room items.
January 4, 2012The actress shares her five favorite dressing room items.
January 11, 2012The Tony-nominated baddie from Porgy and Bess shares his five favorite dressing room items with Broadway.com.
May 30, 2012Broadway's web-slinger shows off his backstage lair.
June 15, 2011The actress shares her five favorite dressing room items
February 1, 2012


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"The Courtyard of Italian Macchina" July 19-20, 2014
1965 Ferrari GTO. Among the world's most historically significant and valuable cars today. Body modified by Allegretti in Italy in 1987. Upgraded competition prepared 4-Liter 12-cylinder Ferrari engine with dry sump with oil cooler and accusump oil system and 6 Webber carburetors intake system. ATl fuel cells with full roll cage. Owner has SVRA and HSR log books and is a concourse winner. Photo credit: Kenneth Heusey Productions
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text: I have the Panasonic Plasma TV model TC-P55GT30. I just purchased the largest SD card I could so I can use it for the TV. I purchased a 128GB SD Card and noticed it didn't work with the TV. I inserted the card and TV indicated that no card was inserted. So I pulled out the manual and it says the TV can handle a max of 64gb SD card. I know, I know...I should have read the manual before buying the card. Anyway, does anyone know if there is a way I can coax the TV in using this SD card? I would hate to have to buy another 64GB card.


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Rua Red has a diverse number of multipurpose spaces including two galleries, performance space, music rooms, meeting rooms and rehearsal spaces which can cater for 2 to 150 delegates. Onsite catering, free car parking and breakout rooms are available.
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Rua Red
RUA RED is a dynamic home for the creation and enjoyment of the arts. Creative spaces around the centre are available to hire by groups and individuals for creative use. Along with partner organisations and tenants, the centre hosts a programme of events aimed at all members of the community, locally, nationally and internationally.


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"Olympus Has Fallen" director Antoine Fuqua works at the White House replica he had built in Shreveport, La.
Director Antoine Fuqua laughed heartily when a cheeky reporter asked him if the president had given him free rein to go through the White House — to do research and prepare background for his film "Olympus Has Fallen" (opening Friday). "Not hardly," said Fuqua with …


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Lindsay Lohan won't be stuck in rehab alone for X-mas -- TMZ has learned, Dina and the fam are making a cross-country pilgrimage to visit her over the holidays ... and big surprise, daddy ain't invited.
Sources close to Lindsay tell TMZ, Dina's hauling the little Lohans -- Ali, Michael, and Cody -- out from Long Island to visit for a couple days next week.
Lindsay originally wanted to fly back east ... and Betty Ford officials signed off -- but sources tell us, the L.A. County Probation Department wasn't so understanding.
It's the most wonderful time of the year ... when you're not Michael Lohan.
Dina Lohan and her lies is why LL is where she is today. Dina has taught all of them to hate ML. She rages about him and has trained all of them to rage on him as well.
Out of the two parents, neither is perfect but one is a master liar and truly detrimental to Linds. That is Dina! BF knows this and that's why they encouraged Linds to patch things up with dad.
Dina lies like we all breathe. I'd take all the kids away from her.
Until or should I say If only a court could step in and put someone else in charge of her money and management and cut her parents out of anything but a personal relationship these 2 pathetic excuse for parents will ride her coat tail even after she is in the grave.It is so sad.
I believe Dina has a raging drug habit of her own. I fear she will supply LL with some nice coke. That way she can go back to having influence over and owning Lindsay.
I hope BF is testing Lindsay. One thing is clear. Dina doesn't seem to have Lindsay's best interests at heart.
What a tragedy. She could probably have made 100's of millions dollars over her lifetime if she had behaved properly.
Come on be fair, we all know TMZ post the WORST pics possible of Lindsay. The recent pics at BF show a lovely young woman looking happy and healthy. Well done Lindsay.
I'm not surprised Michael Lohan won't be there for Christmas. After his promise not to talk about Lindsay was broken within two days, and his recent chat on radio when he described the sexual positions with his ex wife, how Lindsay was conceived, dressing in womens underwear, urghhhh. ENOUGH!
I'm sure Lindsay will be happy to see her brothers and sister and I hope they have a great Christmas.
WTF are you talking about? Dina brought her kids up to hate Michael? Oh I see, then I suppose his drug taking, his alcohol abuse, his physical violence, his years in jail for fraud, beating Dina up in fron of the kids, threatening to kill his kids has nothing to do with it? Your hate of Dina sees you protecting a monster. His abuse didn't stop with his family.
Whilst he was in jail, who looked after the kids? was there for them, made sure they were fed, clothed, DINA! thats who! Michael Jnr was recently awarded the highest award in high school, Ali is home schooled and doing well. Cody is a happy little guy also doing well. Dina is no saint but DON'T come up with your BS and compare Michael with Dina.
Also your unfounded, vile, slanderous comment about Dina supplying Lindsay with drugs is beneath contempt and born solely from hate.
They need a drug sniffing dog to check ol' Dina out. I'm not talking about Lindsay either.
I'm happy for her .... it's Christmas and we have to be at peace .. Greetings to all from the more long and narrow country in the world ... Chile:)
Merry Christmas and Happy New Year.!!!
I'm happy for her ... .. it's Christmas time of happiness and peace for all:)....Greetings to everyone from the most remote country in the world ... CHILE :)


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EQ Epiphany For the first time in my bass playing life I had to adjust the EQ from 12 o'clock across the board. My two main basses are a MIM Jazz and a Schecter Omen Extreme 4. I've always kept the EQ level on both, because I've never had any problem with the way I've sounded (and no one has said anything). I defretted a Yamaha BBN4 myself and never really dug the sound. Finally today it dawned on me, why not mess with the EQ? Sure enough, I move both the mids to 3ish and the low to 1-2 and wow. I was playing a whole new bass. I know I'm a moron, but I was just so used to not having to adjust EQ that I didn't notice.....but I am happy now :bassist: Sorry for the rant. You can make fun of me if you want. I know I deserve it. |
And in my happiness I clicked the wrong forum. I probably should have put this in amps, but I guess this is close enough.... |
Congrats on your newly acquired knowledge. A bit of extra mid-range makes a huuuuge difference in live settings. Next time you use your Jazz in a band setting, try slightly favoring one of the pickups, and boosting the mid range a bit, you'll be amazed at how it cuts! :) |
Mids are where it's at!! Keep experimenting, theres major tone to be found in those knobs!! |
Good for you! It's funny sometimes what we take for granted, and what we can be blind to. I don't lug my own amp to our rehearsal space; there's a bandmate's old Peavey something-or-other combo amp that I plug into. I've had something of a hard time getting a satisfactory sound out of it, until a couple of weeks ago, when I decided to set the mid frequency control pretty low, and the mid band control pretty wide. Major improvement! |
That's why they come with knobs ;) |
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50 experts and 171 advocates oppose the HHS/IOM Contract to re-define ME/CFS.
Check out our IOM Contract Forum for the latest news and to join the campaign.
TheChronicSituation writes about how choosing to live hidden behind even a partial mask can seem easier, especially when it saves on bothersome explanations. But, at the end of the day, pretense can come at a cost - nobody really knowing who you are...
Discuss the article on the Forums.
Help us with the XMRV Survey - feedback, proof-reading, and comments needed
Discussion in 'XMRV Testing, Treatment and Transmission' started by _Kim_, Jan 24, 2010.
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Charlie Sheen was smoking cocaine while he critiqued porn on his TV set for hours before the 911 call ... TMZ has learned.
Sources who were present at Charlie's house during his 36-hour party tell us ... after a man delivered a briefcase full of cocaine to the house early Wednesday morning, Charlie pulled out a small green pipe and started smoking cocaine continuously ... for hours.
There are many wild details, but we're told eventually Charlie ended up in his theater room with one of the porn stars with whom he was partying. They watched 3 hours of porn, as Charlie critiqued the action on the screen.
We're told Charlie, who fancies himself as a porn connoisseur, was questioning his companion about angles and body shots. We're told the porn star was "surprised" by the depth of Charlie's knowledge.
UPDATE: The 911 call was reportedly made by Sheen's neighbors -- "Real Housewives of Beverly Hills" stars Dr. Paul Nassif and wife Adrienne Maloof-Nassif ... after the couple received a call from someone in Charlie's house advising them of the situation.
To therock : let me school you!!
no ****, I have party(d) once or twice in my youth, (not like charlie though) and some retards like @Tony, @Sara, @Nancy start talking crap like they have a clue. everytime they type,their stupidity shines through like a beacon.
to smoke coke ~ which is crack ~ you have to cook it with a baking soda and small amount of water, let it cool and reheat. I have seen it done thousand times, never smoked it though. you cant smoke snorting coke, not at all.
Good time Charlie. Can't help but love him. I hope he changes his lifestyle before he dies of an overdose.
Smoking a "dirty" joint (sprinkled with coke) will make your lips numb. You might get a buzz if the weed was decent, but the coke will have little effect, if any. Sorry.
...this is just what I heard.
The comparisons to Lilo are wrong in that Charlie still shows up for work, apparently on time, and gets the job done, whereas Lilo's chronic lateness and absenteeism is cause for increased production costs, ultimately affecting her insurability. However, from a morality standpoint, it's true that a popular male actor, whether he's addicted to sex, alcohol, drugs, gambling, porn or whatever, is easily forgiven as long as he is entertaining to his audiences, whereas a woman would usually be branded as "trash." On Charlie's side, though, one reason I think he is forgiven is, in addition to the double standard, is that he does take the time to be nice to the paparazzi and his public, and does not treat them rudely or arrogantly (how he treats people in his private life I don't know).
you can't smoke coke, snorting coke, without it being in rock form, which is crack. CHARLIE IS SMOKING CRACK
Posted at 6:48 PM on Jan 27, 2011 by They are crayz!!
You can snort coke or shoot it , nobody smokes Cocaine, only crack cocaine. Charlie definetley needs Rehab now. I lost a family member to cocaine addiction. blew her heart..
Posted at 6:53 PM on Jan 27, 2011 by Jo
W.R.O.N.G. Where are you people getting these ideas? Why are you posting them in a public forum where thousands of people can see how wrong you are? And, how can you be so insistent that you are correct, when it is OBVIOUS that you have no knowledge whatsoever in regard to these matters? You don't even need to have actual experience with cocaine to have knowledge about it (although it helps) - you could just use Google and find out in less than five minutes that you are completely incorrect.
There is no - again, NO - reason why plain cocaine cannot be smoked. It is a fairly common practice. The high that the user gets from smoking (powdered) cocaine is more powerful and intense than the high that one gets from snorting it. The high is short-lived, however, and because the cocaine melts and vaporizes, it's a pretty wasteful practice.
Charlie Sheen is a f#*ked up mess!!!
He's one of the biggest donators to the drug cartels and empowers more killings and smuggling. He should be fired from
the network and locked up in rehab for life.
Dear Harvey Levin and TMZ staff,
You're always at the first place,the only one who informe us about any important event.
Excelent like You are
True like You are
Strangest headline I've read in a long time. What next? "Kelsey Grammer Studied Knitting, Aquired Mistress Before Dumping Camille"? Oh, & that pain he's having? That's the disintegration of his stomach lining.


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Costa Rica Center: Jan Term Program for Freshman Honors StudentsThanks for your interest in Whitworth's Costa Rica Center Jan Term Program. Before you access the online application for the program, please be aware of the following.
Academics: Co-Curricular Programs:
Application/Selection Process: Costs:
This program is offered every Jan Term to freshmen admitted with honors to Whitworth University. A semester-long program at Whitworth's Costa Rica Center is available to sophomores, juniors and seniors. Please click here to access the Jan Term Program Application. |


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Amanda Bynes appears in court in NYC facing charges of reckless endangerment, tampering with evidence and marijuana possession after allegedly throwing a bong from her apartment window. May 24, 2013.
Hello, Future Husband of Ours. – The Berry | |
You Need To Follow These Twitter Hotties – The Berry | |
Selena Gomez Is Just Showing Off Now – Popoholic | |
Christian Grey Gets Even Sexier... – Lainey Gossip | |
Kristen Stewart Is Playing Games With Robert Pattinson – ICYDK | |
Jared Leto Proves That He's Still Sexy – Lainey Gossip |


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2010 Domaine Raspail Ay Gigondas (In Store Only)
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750ml Bottle $341.89
Case of 12
750ml Bottle $341.89
Case of 12
Item #59234
Size: 750ml
Type: Red Wine
Varietal: Red Rhone Blend
Country: France
"Youthful purple. Intriguing perfume of black raspberry, cherry compote, tobacco and lavender, complicated by a strong spiciness. Broad but focused red fruit flavors are firmed by juicy acidity, showing exotic notes of candied flowers and star anise. Silky tannins add shape to the long, attractively perfumed finish."
Reviewed by: International Wine Cellar - 92 to 94pts
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2010 Domaine Grand Veneur Lirac Rouge Clos de Sixte
"Black currant, spring flower, licorice and crushed rock aromas jump from the glass of this dense ruby/purple-colored, full-bodied, beautifully pure, textured and dense Lirac. It should drink well for at least a decade."-Robert Parker
$22.99 / 750ml Bottle
$262.09 / Case of 12
$262.09 / Case of 12
2011 Domaine Saint Damien Gigondas La Louisiane
"Bright purple. Seductive aromas of dark berry preserves, potpourri and smoky minerals. Sweet, expansive black raspberry and cassis flavors are complemented by floral pastille and fruitcake qualities, with gentle acidity providing lift. Shows both power and finesse, closing sweet and smoky, with a touch of warmth."
$28.99 / 750ml Bottle
$330.49 / Case of 12
$330.49 / Case of 12
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The Quarry
Published on Wednesday, 30 November -0001 00:00
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Waite Park; hours 8 a.m. to 1/2 hour before sunset
This 643-acre regional, county-owned park is located along County Road 137 and 7th Street South. The park features oak woodlands, oak forest, wet meadow, wet prairie, bluff lands, rock outcroppings, and granite quarries. Plant life includes everything from oaks and aspens to yellow ladyslippers, Indian paintbrush, prickly pear cactus, and the tubercled rein orchid. There is a small fee for admission. Check www.waitepark.org for events schedule.


text: Back to School, But Development Never Stops Competition is prevalent in all walks of life, whether it is one of our golfers competing for a major title, news graduate attempting to stand out from their peers when seeking that first job, or our firms competing with others for business, and even Northern Ireland itself competing for inward investment. Interestingly, this mismatch was most pronounced for postgraduate qualifications, such as the MBA, with over 80% of managers who undertook this type of course, rating their developmental experiences as most effective. However only 20% of respondents had the opportunity to complete such courses in the first place. So perhaps businesses are not taking advantage of the programmes of study that are available. The content of this article is provided for information purposes only and does not constitute professional or other advice. What Can a Business Advisor do for me? Half Way Point in the Lost Decade? Corporate Social Responsibility - a closer look at a contested concept Effectuation Leadership - Transforming Uncertainty into Opportunity Company Directors need to think again Do we need Leaders, Managers or both? - Two Heads, one body? Learning That Does The Business


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Journalists surround Dorian Satoshi Nakamoto as he emerges from his Temple City house amid a frenzy of speculation that he is the creator of the virtual currency bitcoin.
PHOTOGRAPH BY: Allen J. Schaben / Los Angeles Times
LinkActor Tyrese Gibson hugs a student during a surprise visit to his alma mater, Locke High in South L.A., where he shared his personal story in hopes of inspiring teens to stay in school and graduate.
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LinkGladys Ortiz, left, and Blanca Ayala try on shoes and prom dresses offered by the Assistance League of Southern California. Nearly 60 homeless or low-income girls from 17 L.A. Unified schools attended the league's Operation School Bell Prom Day in Hollywood to find outfits and to have their hair and makeup styled.
PHOTOGRAPH BY: Francine Orr / Los Angeles Times
LinkLaker Pau Gasol is double teamed by Clippers DeAndre Jordan, left, and Willie Green in the 2nd quarter at Staples Center in Los Angeles. The Clippers routed the Lakers 142-94.
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LinkLike a frozen waterfall, a wall of ice more than 40 feet high stretches down to the high-tide line on Otter Cliffs overlooking the Atlantic Ocean in this time-exposure at Acadia National Park in Maine.
PHOTOGRAPH BY: Robert F. Bukaty / Associated Press
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LinkMussie Oberlander is escorted by relatives during her traditional Jewish wedding in the Obuda Synagogue in Budapest, Hungary.
LinkPfc. William Berczik covers his ears during a live-fire exercise with 120-mm mortars in the desert near Kandahar, Afghanistan. President Obama recently ordered the Pentagon to begin contingency planning for a pullout from Afghanistan by the end of 2014 if Afghanistan President Hamid Karzai or his successor refuses to sign the Bilateral Security Agreement.
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LinkDogs and their owners arrive to attend the second day of the Crufts dog show in Birmingham, England. Crufts was first held in 1891 and sees thousands of dogs vie for the coveted title of Best in Show.
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LinkA demonstrator holds a banner before a march to the China liaison office in a rally to support of Liu Xia, pictured on banner, the wife of imprisoned Chinese dissident and Nobel Peace Prize winner Liu Xiaobo, in Hong Kong.
PHOTOGRAPH BY: PHILIPPE LOPEZ / AFP/Getty Images
LinkMuhammad Yasin Malik, in red, chairman of pro-independence group Jammu and Kashmir Liberation Front (JKLF), scuffles with Indian policemen as they try to detain him during a protest march in Srinagar, Kashmir, India
LinkFishermen pull their net from the sea as the sun sets on Gampong Jawa beach in Banda Aceh, Indonesia.
PHOTOGRAPH BY: Heri Juanda / Associated Press
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Wednesday's Pictures in the News features the thrill of victory and the agony of defeat in China, where a Japanese sprinter tumbles to the track at the finish line during her... View Post»


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If you are looking for trendy restaurant and bars and you don't mind you wallet becoming a bit lighter, check out the Horie neighborhood in Osaka, located within walking distance of Namba, Shinsaibashi and Amemura. Many establishments here offer top-class gourmet cuisine and excellent drinks, and each shop has its own unique style. If you only plan to splurge once when you are in Osaka, come here.
One of my favorite restaurant/bars in the area is Cafe Absinthe. It specializes in Mediterranean fusion cuisine (the cooks here are amazing), and it also sports a wide selection of imported European absinthe. Drinking absinthe here was not my first experience, but Cafe Absinthe's drinks tasted great and nearly had me out cold after two drinks–one straight, one in cocktail form mixed with Midori–despite my huge dinner and relatively high tolerance. Another great thing about Café Absinthe is the food is up to Horie standards, but the prices are quite reasonable in comparison to many other places nearby. The service is also stupendous.
Cafe Absinthe is open from 11:30 am to 3:00 am, every day except Tuesday. It is located a short distance from Nishiohashi Station (Nagahori Tsurumi-ryokuchi Subway Line) or Yotsubashi Station (Yotsubashi Subway Line). The Cafe Absinthe website can be found here (directions are listed, you can look at this Google Maps link).You can call them (06-6534-6635) if you get lost walking from the station (they speak both English and Japanese well).
Yeah I've been there. Blew my socks off.
Hmmm…while absinthe does sound intriguing (and I LOVE mediterranean food) I have a low tolerance and you might have to carry me home.
I've always wanted to try absinthe, looks like I'll get my chance when I go to Osaka =P
Hey very nice blog!!….I'm an instant fan, I have bookmarked you and I'll be checking back on a regular….See ya
thanks for the great quality of your blog, every time i come here, i'm amazed.
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Buy it now on Amazon.com, Amazon.co.uk, Amazon.de, Amazon.fr, Amazon.it, Amazon.es, or through my online store in Japan!.
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name game
Posted by Mark J. Miller on October 23, 2012 02:18 PM
When Jay-Z and Beyonce named their new daughter Blue Ivy back in January, most people said, "What the heck?' Boston-based entrepreneur Veronica Alexandra, however, was saying something else.
The 32-year-old's response was more like "Uh-oh." After all, her wedding and event planning business, which has offices in Florida and Southern California, happened to have the very same name.
So when the music superstars went to trademark the name for their daughter, Alexandra did the same. And now, the Boston Herald reports, she's won trademark protection for Blue Ivy.
"I definitely needed to protect what it is I've been living on," Alexandra told the Herald. "Now it's time to create the partnerships and business avenues I'm planning on doing, period."Continue reading...
More about: Jay-Z, Beyonce, Blue Ivy, Trademark, Legal, Naming
chew on this
Posted by Mark J. Miller on October 16, 2012 03:09 PM
Dunkin' Donuts thinks it can have a winner with the bagel centers, just as it did when it turned doughnuts on their glazed heads and created Munchkins, sparking a doughnut hole war in the U.S. with Canada's Timbit-flinging Tim Hortons chain. As spotted by the Boston Globe, the people that brought you America Runs on Dunkin' filed for a "Bagel Bunchkin" trademark back in May and plans to use it to sell bite-size bagel pieces in the U.S.
The chain already has a pretty good lock on bagel sales, as the biggest seller of bagels among quick service restaurants in the U.S. Two years ago, it launched Bagel Twists, but is now looking to expand its bagel offerings. However, it may not be able to move forward with their desired name.
The US Patent and Trademark Office "tentatively rejected the Dunkin' application, noting that the Fred Meyer Stores supermarket chain already registered the rights to the name 'The Bagel Bunch' for its traditional bagel line," the Globe notes. Dunkin' Donuts is nearing the end of the time window to appeal.Continue reading...
More about: Dunkin' Donuts, Munchkins, Tim Hortons, Timbits, Bagels, Bagel Bunchkins, Naming, Trademark, Legal, QSR
Posted by Shirley Brady on October 12, 2012 05:02 PM
To promote Lenovo's new IdeaPad Yoga (a hybrid tablet and laptop that can be configured, yoga-like, into various 'modes' or 'poses' including bending backwards), the brand released "The Pursuit," a film-like short (that's the director's cut, above) that was shot in Hungary. The Bond-like heroine's mission: "Find the Yoga, uncover the code, make the switch. But with the opposition in hot pursuit her skills and the dynamic moves of the Yoga will be put to the test."
"Yoga was actually the code name," says Lenovo CMO David Roman, "but the code name was so logical — it was just a perfect fit — that it ended up becoming the real name. And it was justifiable to have a name [as opposed to a number] because it really is a new category."
The creave name stands in contrast to Lenovo's "ThinkPad Tablet 2," for example, which may get renamed. "We are looking at our naming overall," Roman says. "We don't feel that our naming is up to snuff. It can be confusing. Taken product by product it makes sense, but put them together it doesn't."
More about: Lenovo, Launches, Campaigns, Advertising, James Bond, Naming, Verbal Identity, ThinkPad, Technology, Computing, Tablets
brand strategy
Posted by Dale Buss on October 1, 2012 02:22 PM
A major part of the logic behind the split-up of Kraft into snacks go-getter (and naming-challenged) Mondelēz International and its more tired North American grocery business is to create a "global snacking powerhouse" — and spur growth in the latter enterprise.
As Forbes noted, Kraft is moving from the New York Stock Exchange to NASDAQ with the move to spin off its North American business and rebrand its corporate parent: "Kraft is keeping its faster-growing global snacks business into a new company named Mondelēz International, ticker MDLZ, while its spun-off North American grocery business will keep the Kraft Foods name but trade under ticker KRFT. Both stocks will list on the Nasdaq when the breakup is complete, and the KFT symbol will be retired."
Now that Kraft Foods Group can begin selling shares with its own listing as an independent company after the market's close on Oct. 1st, it's time for Kraft to fulfill investor expectations as Mondelēz (which will debut on Oct. 3rd, with a defiant macron over its final 'ē') is considered to be the higher growth stock.Continue reading...
More about: Kraft, Kraft Foods, Mondelez, NASDAQ, Jell-O, Cool Whip, Mio, Planter's, Velveeta, CPG, M&A, Coca-Cola, Dasani, Kraft Marcaroni and Cheese, Cadbury, Nabisco, Trident, Oscar Mayer, Halls, Naming, Logos
retail watch
Posted by Shirley Brady on September 27, 2012 11:01 AM
H&M has announced that its new store brand, & Other Stories, will launch in Spring 2013 in "selected European countries," with an online hub at stories.com (which was registered in March), and a waiting Facebook page and Twitter feed.
Along with the news that H&M's U.S. e-commerce launch has been moved to Summer 2013, H&M commented on the pending & Other Stories launch in the company's third quarter earnings update, which was softer than expected —Continue reading...
More about: H&M, Retail, Fashion, E-Commerce, & Other Stories, Online, US, Europe, Sub-Brands, Brand Extensions, Naming, Domains, Verbal Identity, Facebook, Twitter, Social Marketing
Posted by Mark J. Miller on September 13, 2012 04:01 PM
Any other major brand, Apple is vigilant about protecting its trademark and image around the world. But sometimes things can go a teensy bit too far, such as when Kellogg threatened to sue a small nonprofit because it used a toucan that looked nothing like Froot Loops' Toucan Sam for its logo.
Kellogg eventually backed off and contrite. Apple, as if it didn't have enough to keep it busy, has started the process on what could end up being a similarly silly case. What's caught the company's attention is an online grocery in Poland (a "delikatesy internetowe") that uses the URL A.pl (get it?), according to Reuters.
Apple isn't just unhappy with the site's name. It also claims that the grocery copied "one of Apple's icons to its logo and (is) riding its coattails to win customers," Reuters reports.Continue reading...
More about: Apple, A.pl, Retail, Logos, Domains, Trademarks, Legal, Naming, Verbal Identity, Visual Identity, Ping, Twitter, Facebook, Social Marketing
trademark wars
Posted by Mark J. Miller on September 6, 2012 01:12 PM
The ice-cream company that gave the world Schweddy Balls and Karamel Sutra isn't apparently amused by somebody using the name Ben & Cherry's. Perhaps Ben & Jerry's discomfort comes from the fact that the somebody in question is a hardcore porn film producer.
The Vermont-based, Unilever-owned B&J's has filed a trademark suit against B&C's, the Associated Press reports, in order to stop them "tarnish(ing)" the ice-cream maker's name.
Ben & Cherry's doesn't just use a variation of the B&J's name and logo on its films; it also gives its videos names based on Ben & Jerry's flavors. Witness "Boston Cream Thigh," at right, ''New York Fat & Chunky," and "Peanut Butter D-Cup," the AP reports. Not only that, the packaging of the films contains elements that appear on Ben & Jerry's packaging, such as "a grazing cow, green grass and large white puffy clouds."
It's not that Ben & Jerry's is averse to hanky panky; after all, the brand using a more G-rated bit of romance – spooning (get it?) – to help sell its new Greek Frozen Yogurt.Continue reading...
More about: Ben & Jerry's, Unilever, Ben & Cherry's, Trademark, Legal, Logos, Naming, Porn, Facebook, EPA, Environment, Corporate Citizenship, Ethics, Greek Yogurt, Entertainment, Movies
personal brands
Posted by Matthew Moore on August 6, 2012 11:02 AM
It's a little unusual that Calvin Cordozar Broadus, Jr. thinks he's Bob Marley reincarnated, especially given he was 9 years old when the reggae legend passed. Snoop Dogg's name change to Snoop Lion is not all that unusual among the celebrity set, however.
Snoop Lion, as the artist formerly known as Snoop Dogg will now be known, claims he found himself on a trip to Jamaica in January and is pursuing a higher calling. "I have always said I was Bob Marley reincarnated," he announced. "I feel I have always been a Rastafari. I just didn't have my third eye open, but it's wide open right now."
Apparently tired of singing about drugs, alcohol, and women, Snoop Lion is — of course — releasing a reggae album under his new persona, titled — of course — "Reincarnated." He's calling it an album he hopes his "kids and grandparents can listen to."Continue reading...
More about: Personal Brands, Snoop Dogg, Snoop Lion, Music, Entertainment, Naming, Trademark, Logos
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Analyst Research
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Provider: Thomson Reuters Stock Report
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Provider: Reuters Investment Profile
Provider: Wright Reports
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Horseshoe Metals Ltd Kicks Off $1.8 Million Capital Raising To Advance Copper Exploration
Horseshoe Metals Ltd announced details of a share placement which, once finalised, will raise $700,000 for the Company. The Company also announced a non-renounceable rights issue to existing shareholders to raise an additional $1.173 million. The placement of 10,000,000 shares at $0.07 per share will be undertaken in two tranches, being: (i) A total of 7,857,000 new ordinary shares have been placed with a number of new and existing sophisticated investors at an issue price of $0.07 per share. (ii) a total of 2,143,000 new ordinary shares will be placed with one or more entities associated with director Michael Fotios at an issue price of $0.07 per share. Details of the rights issue are: One new ordinary fully paid share (New Share) for every $0.05 shares held at the Record Date, at an issue price of $0.07 per New Share; Approximately 16,755,500 New Shares may be issued, raising $1.173 million before expenses; The New Shares will rank pari passu with the existing issued shares of the Company; and The issue is presently not underwritten, however negotiations are ongoing with a number of parties/major shareholders about possible participation as sub-underwriters. Follow the Company's recent announcement of a 40% increase in its Mineral Resources at the Horseshoe Lights Project, the funds raised will be used to fund follow up exploration including geophysical survey work and drilling at the Horseshoe Lights and Kumarina Projects; and for working capital purposes.
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Computer Music highlights
14th Aug 2004 | 13:36
Computer Music highlights
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Stanley Crooke - Chairman of the Board, President, Chief Executive Officer
Wade Walke - Executive Director Corp. Communications & Investor Relations
Lynne Parshall - Chief Operating Officer and Chief Financial Officer
Richard Geary - Senior Vice President of Development
Jim Birchenough - BMO Capital
Stephen Willey - Stifel Nicolaus
Chad Messer - Needham & Company
Edward Tenthoff - Piper Jaffray
Charles Polsky - William Harris Investors
Isis Pharmaceuticals, Inc. (ISIS) Special Call October 18, 2012 7:30 PM ET
Good day, ladies and gentlemen and welcome to the Isis Pharmaceuticals' conference call to review the FDA advisory committee panel vote of KYNAMMRO. As a reminder, this call is being recorded for replay purposes.
I would now like to hand the call over to your host for today, Dr. Stanley Crooke, Chairman and CEO. Proceed, sir.
Stanley Crooke
Thank you. Good evening and thanks everyone for joining us on the call today. I will review the recommendations made by the FDA advisory committee panel and then we will open up the call for Q&A.
Joining me on the call are our Lynne Parshall, our Chief Operating Officer and CFO, Richard Geary, Senior Vice President of Development, Walter Singleton, Vice President, Development and Chief Medical Officer and Wade Walke, Executive Director of Corporate Communications & Investor Relations.
Wayde, would you please read our forward-looking language statement?
Wade Walke
Yes. Thanks, Stan. A reminder to everyone that this webcast includes forward-looking statement regarding the development activity in therapeutic and commercial potential on the safety of KYNAMRO. These statement describing Isis's goals, expectations, financial or other projections, intentions or beliefs including the planned commercialization of KYNAMRO in the forward-looking statement and should be considered an at-risk statement.
Such statements are subject to certain risks and uncertainties, particularly those inherent in the process of discovering, developing and commercializing drugs that are safe and effective for use of human therapeutics and in the endeavor of building a business around such drugs. Isis's forward-looking statements also involve assumptions that if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements.
Although Isis's forward-looking statement reflects the good faith judgment of its management, these statements are based only on facts and factors currently known by Isis. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Isis' progress are described in additional detail in Isis' annual report on Form 10-K for the year ended December 31, 2011 and on its most recent quarterly report on Form 10-Q which are on file with the SEC. Copies of these and other documents are available from the company.
Now, I will turn the call back over to Stan.
Stanley Crooke
Thanks Wade. Let me begin by saying how pleased we are to have completed this next step in bringing KYNAMRO to the market for patients who are at extreme cardiovascular risk. I would like to thank the Genzyme and Isis regulatory teams for doing a great job with the submission.
We have aged patients, Christian, Catherine, Brad and Dave, whose compelling testimonies put a voice and a face to this devastating disease and the experts who joined us today and helped the team tremendously in preparation for the panel and of course the FDA and the panel itself for their thoughtful analysis. We are very encouraged by the committee's support for KYNAMRO at today's advisory committee meeting.
As the panel noted, there is significant need for new treatment options for patients with Homozygous FH. We continue to work with Genzyme on the next steps for KYNAMRO approval for Homozygous FH in the U.S. Finally, the regulatory process in Europe is progressing and we are on track to hear from them this year. Given that the European process is still in progress, of course, we cannot discuss it in any more detail today.
Given the work that lies ahead of us and the fact that we are very much still in the midst of the regulatory process, our comments today will be very brief. There is one issue that has caused confusion that I want to clarify. Cancer.
First, as you saw today, an analysis that actually compares incidence to exposure, a proper analysis, shows that the KYNAMRO and placebo groups did not differ in the incidence of cancer. Further, as Dr. Chadner said today, it's very unlikely that the advance cancers observed could have been caused by KYNAMRO.
Now let me deal with the animal carcinogenicity studies. Carcinogenicity studies involve administering large doses of a drug throughout the lifetime of an animal. As is standard within the industry, we work with independent and experienced contract research organizations who complete and interpret these complex results and they do that in the context of their broad experience in dealing with aged animals. Furthermore, as required, carcinogenicity studies are performed only after protocols are agreed and doses selected together with the FDA.
In the KYNAMRO studies, the conclusions from both carcinogenicity studies reached by the independent scientists who perform the studies were the same. All findings were incidental or unique to mice and not considered relevant. They concluded this after finding those statistically significant different from control animals using four separate statistical tests. A fifth, very sensitive statistical test of a mouse study showed an increase in adenocarcinomas that were deemed mouse specific and occurred only at the mid dose.
The conclusion of the primary and consulting pathologist was that that finding, and now I am quoting from the report itself, "was considered incidental and not test article related as it was not dose related and the increase was only slightly greater than the historic control rate". Of course, similar observations are made in many carcinogenicity studies for many drugs.
We were obviously very encouraged by these data and as such, when asked, our statements were based on the conclusions of this experienced independent group of scientists with which we agreed. The suggestion that Genzyme or Isis failed to be forthcoming is wrong. It is true that an FDA reviewer came to a different interpretation. Differences in interpretation of data particularly from such complex studies as these are a natural part of the scientific process.
With that I want to thank you for your interest and open the call up for questions-and-answer. Paris, can you set us up please?
Question-and-Answer Session
(Operator Instructions) Your first question comes from the line of Jim Birchenough with BMO Capital. Please proceed.
Jim Birchenough - BMO Capital
Congratulations on the outcome. A few questions just stemming from the panel and I am sensitive to what you can say but one of the topics was related to the lack of data with concurrent apheresis and so do you have a sense of what proportion of Homozygous FH patients don't have access to apheresis because that seemed to be one of the areas of unmeet need the FDA panel seem to think about here?
Then I guess, the other part of it is, just as we think about the pipeline and what we have learned here with KYNAMRO, injection site reactions came up, flu-like symptoms and immune effects and some difference of opinion on pre-clinical cancer signal. So what can you tell us about efforts going forward to try and limit those effects and get a better level of understanding with FDA? Thanks.
Stanley Crooke
First, and Richard and Walter can amplify on this, the fraction of patients with Homozygous's severe FH that are able to obtain and tolerate apheresis is extremely low. As was pointed out several times during the last few days, apheresis itself is associated with significant issues, significant side effects and significant problems and as a consequence people who begin apheresis very often discontinue.
It is interesting, in that, we chose to do rigidly controlled Phase III trials with a placebo control and no dose adjustments allowed in response to ALTs or any other observations and we chose not to do an inter-patient dose escalation study in patients with apheresis because we felt that that wasn't an appropriately controlled trial. I think every thing that we know about apheresis and KYNAMRO, as Dr. Moriarty said today, argues that KYNAMRO will be additive to apheresis and the studies are in progress to do that.
Anyone want to add to that answer?
Lynne Parshall
Stan, this is Lynne. I can just add a little bit of more granularity on the patient numbers. In the United States, there are two different group of patients. One, apheresis, that's of the 12,000 to 15,000 patients in the United States who are eligible for apheresis. I apologize. I don't have that number broken down, Jim, for Homozygous and it is a larger percentage of the Homozygous population than for the rest of those patients who are the severe Heterozygous.
But as you can see from those numbers, with 200 to 300, out of 12,000 to 15,000, it's a very small fraction of patients but in the United States that are apheresed of the patients who are eligible today.
Richard Geary
And most of what they tell us is most of the patients who are being apheresed in the United States are actually Heterozygous FH patients. So, the best estimate I have heard comes from marrying the gallon who thinks its something like 10% of the Homozygous actually either are able to access a unit of close enough to a unit to use it or are able to tolerate it.
Stanley Crooke
Now, on to the technology questions. Lets deal with carcinogenicity first. Carcinogenicity studies are, as I said, enormously complex and they are subject to all sorts of differences in interpretation. The vast majority of carcinogenicity studies have significant observations, as did (inaudible) in their study and that's natural because as these animals age and die, they develop all sorts of lesions.
So we believe that this carcinogenicity study very strongly supports the potential for other second generation antisense drugs to be used for a variety of indications. I think it is particularly encouraging given the fact that the mouse and the rat are the most sensitive species to the non-specific information that these agents produce.
Second, with regard to inflammatory processes, I think we have great news. We showed, and as we have reported for 20 plus years, antisense drugs are prone to producing pro-inflammatory effects that are of different levels and types depending on the species and the mouse and the rat are by far the most sensitive species. In the KYNAMRO study, what we did was that we evaluated and with detailed time courses after every single dose in the protocol that we call CS32 all of the systemic mediators of information that we could measure. In that study, we showed no significant change in any systemic inflammatory signal. So I think that's great news.
With regard to the other potential issue on inflammation which is the antibodies, these assays, the antibodies that we saw were low TIGER, dated not after the safety of efficacy of KYNAMRO in any meaningful way. So we think again that's good news.
Finally, in addition, tolerance. We have spoken for several years about all of the learnings that we have had as a result of giving KYNAMRO to patients who had no experience taking subcutaneous drugs and physicians who had no experience really giving them. We learned along the way that education and Isis make a big difference. Now we learned that as a result of our experience and over time our patients' tolerance for KYNAMRO improved.
We think that those learnings were applying to every other drug in our portfolio and if you look at, the experience that we had with KYNAMRO as a learning experience about how to handle subcutaneously administered drugs in these kinds of patient populations, I think you can see why we are very optimistic that the tolerance for our drugs will be much more acceptable as we move forward. Now, while we are at it, why don't we deal with the discontinuations, because I think that what we have learned about that was perhaps lost a little bit today.
Richard, would you like to handle that one?
Richard Geary
Sure. So in our Phase III program, it was reported today and I think most you have known about the HoFH program for some time, that 82% of the patients actually completed that pivotal trial and then there was this long-term extension trial where quite a number of FH, both of our HeFH Phase IIIs and our HoFH were able to roll over this long-term extension and it was there in the long-term extension and many patients were not retained long-term. In part this was because of difficulties in the administration of this study. Early on, the HoFH patients were only given a one year consent to go into this and many of the sites got out of the study after the one year and still it at least appeared that we lost a lot of HoFH. In actuality, the HoFH that were able to consent for two years, we have more than 80% retained to the two years.
So when we spoke to the physicians at these high retention sites, particularly those that put their HoFH patients in the two year portion of this trial, we learned that and some of these are now their fourth year. They told us that the reason they were able to retain these patients is really due to frequent communications they have with the patients and their families and education of the patients in regard to the severity of the disease. So it's very much the relationship that they have with their patients. And I can tell you that all of these learnings are going into our patient and physician training which is at the core of the Genzyme program.
Stanley Crooke
Just to finally bring that to a close, we are taking advantage of all the things that we have learned in this process and for example we learned that if you do a long-term study in South Africa where people have to travel many, many scores of miles to get to the clinic, your dropout rate is going to be higher. Of course we also learned that while it's clinically, from a clinical trial perspective, the very best practice, in terms of quality of data, to allow no dose adjustments.
We know now that dose adjustments can be excepted and understood by people who have to evaluate these trials and so there are many things that we are capable of doing today that we chose not to do in the very first drug that we developed to this spot and all of those learnings are being applied everyday as well as additional learnings that we have had out of the regulatory process that perhaps we will talk about another day.
I think we have beaten that to the ground and I believe we can move onto the next question.
Your next question comes from the line of Stephen Willey with Stifel Nicolaus. Please proceed.
Stephen Willey - Stifel Nicolaus
Congratulations on the outcome today. Just a quick question, I guess, on focus. I know that studies being conducted under SPA right now but just in listening to the tone of the panelists today, it certainly sounded like they would want to see something in addition to LDL reduction data, in terms of being able to expand the label. So, I am just wondering, as you heard their feedback today, does that that then, maybe, put you and/or Genzyme in a position whereby you might want to amend the protocol? Maybe get some of that additional score out of data that seem to be asking for?
Stanley Crooke
Well, the SPA was negotiated with the FDA, recognizing that outcome studies are not possible in the severe patient population either. Carefully considering all of the options available for surrogate measurements of atherosclerosis and it was jointly concluded that it made much more sense to do a high quality experiment and we think that's what we are doing and not attempt to ask those questions in this particular trial.
Richard, maybe you want to add to that?
Richard Geary
No, I think that's exactly right. We did consider imaging but it's not an endpoint that's acceptable to the regulators. I think there was a lot of speculation about what might be able to be done but experts have looked at this very carefully and for this particular trial which, again, has been agreed to with the FDA, its still LDL-C is the strongest surrogate.
Stephen Willey - Stifel Nicolaus
Okay, and I understand there is some debate as to the pro-inflammatory markers that are being turned on. Can you, maybe, just elaborate a little bit as with respect to how the 2.5 chemistry maybe a little bit different than the 2.0 that mipo incorporates with respect to some of these preclinical findings that we seem to be focusing on today?
Richard Geary
The preclinical findings, again, our judgment, and its not just our judgment, it's the judgment of the contract house that did the work are the dose findings were incidental and not relevant human beings. So we think that's really great news.
Don't forget that while we have only done one carcinogenicity study in with second generation antisense drugs, we have done many one year studies that have been submitted to regulatory agencies to support clinical trials in all sorts of diseases. So we have a great deal of justification of being confident that these animal observations are manageable and we have spent a lot of time understanding the mechanisms, understand species characteristics and having detailed explanations for people who want to invest the time to understand them.
So we feel very good about that. With regard to the clinic, I think the mipomersen data are really compelling. We did as thorough a study as can be done today looking for signs of inflammatory markers. That study was vetted by all of the major people involved or many of the major people involved in the questions of information and cardiovascular disease, including Paul Ridker who because of schedule couldn't be at the meeting today and all of them, and the FDA were very comforted by the data that we had.
The third point is, as we have reported a couple of times, as we have continued to understand how to manage physicians and patients with mipomersen, the tolerance for KYNAMRO has steadily improved. As we showed you in the later parts of CS6, or the open label extension, so when you look at dropout rates and tolerance across all of the KYNAMRO experience, you are looking at a blend of a lot of early experiences and then later experiences which are much more positive.
Finally, I think we have mentioned it several times that we have continued to advance our screening process for generation two and we certainly are seeing improved tolerability in a variety of dimensions and greater potency out of our generation two drugs. Of course, the lower the dose, the better your tolerance because these are all local dose effects.
Now, with regard to generation two five, we think their properties are going to be similar to the very good performance that we are seeing today out of our latest group of generation two drugs with regard to these nuisance tolerance side effects.
I hope that answers your question.
Your next question comes from Chad Messer. Please proceed.
Chad Messer - Needham & Company
Hello, can you guys hear me okay?
Stanley Crooke
Yes, we can hear you.
Chad Messer - Needham & Company
All right, I apologize if drop out. I am actually on the train heading back from the FDA panel, heading back up to New York. Just one quick comment and then a quick question, if I may?
My comment is that having just sat through that panel, staring everyone else at Isis, I think that the panel was probably less concerned than I was worried that they might be about the carcinogenicity concerns raised by the FDA in the documents. So I commend the panel on taking that debate with sort of necessary perspective that you pointed out.
Question to you is this, so you have been through this panel with the FDA before. Even here, backed the decision by them, we are expecting to hear approval decision from the European authorities. How would you compare and maybe contrast a little way the process has gone in the U.S. versus in Europe for you guys? Thanks.
Stanley Crooke
Chad, I would be delighted to answer that but I just think it's not prudent while we are in the midst of the European and U.S. processes. Suffice to say that the European process is proceeding and we continue to be pleased with the progress.
Sorry, there is a great deal of noise.
Chad Messer - Needham & Company
Stanley Crooke
Maybe, I think that's probably on the phone on the train. So we probably ought to stop that and we will make this the last question. Next question.
Your next question comes from the line of Ed Tenthoff, Piper Jaffray. Please proceed.
Edward Tenthoff - Piper Jaffray
Great, thank you very much. My congratulations as well. I think the team did a great job on this. Two quick questions, if I may. Following up, firstly, can you confirm whether or not you guys were on the docket CHMP this month for review?
Second question is having to do with the size of the market. In the past you guys have discussed something as high as 3,000 patients in the U.S. and maybe as high as 18,000 patients in Europe with the severe Heterozygous label. Does the panel today cause you to rethink or change those estimates in terms of appropriate patient population at all?
Stanley Crooke
Lynne, why don't you take that?
Lynne Parshall
Sure, Ed. Nothing about the panel today causes us to change our estimates either of the actual number of patients or the accessible number of patients. With regard to the CHMT docket, in the sense that we are in the middle of the regulatory process with Europe, its very different process from the U.S. It's proceeding at pace and so it's really not appropriate for us to give much more granularity on that right now.
Stanley Crooke
I think we will take one more question and then we have got a lot of work to done now and it's a great kind of work to do, so we want to go and do it. So one more question and then we are going to call it in.
Your next question comes from the line of Charles Polsky. Please proceed.
Charles Polsky - William Harris Investors
Hi, Stan, congratulations on the positive panel. I missed the very beginning of this call. So if my question is redundant, I apologize. It seemed to me the part of the expert at the panel today, the toxicity concerns they had were a mixture of the mechanism of action of this particular drug and as one of the experts expressed his individual concern, that acting at the level of RNA was pro-inflammatory.
So the question is what read-through do you see from looking at the concerns that were raised today, looking through the rest of the pipeline and what do you think that does in terms of having to increase your calming concerns on the part of regulatory agencies that are not familiar with systemically administered antisense agents?
Stanley Crooke
Charlie, I did cover that earlier. So maybe I can just answer it very briefly and then I will be glad to talk with you by phone tomorrow. How about that?
Charles Polsky - William Harris Investors
That sounds great.
Stanley Crooke
So, my overall view is that this is great news for the technology. We have shown in careful studies that the inflammatory infection manner. We can't identify systemic mediators of inflammation despite the fact that we tried very hard. We have learned that tremendous amount of how to manage the nuisance side effects. The flu-like syndromes and the injection site reactions and we are already doing much better job of that.
We have learned a lot about what are acceptable clinical trial designs and how you are rewarded for very, very rigid clinical trial designs. Not too much. So all in all, we feel that the learnings from this have enabled us to do better and we are focused not more and so we are feeling very good about it. Maybe I will just leave it at that, if I may, and then I will be glad to talk to you by phone tomorrow.
Is that okay, Charlie? Any other comments from my colleagues?
Richard Geary
Stanley Crooke
If there are no more questions and no more comments, I think the Isis people will get back to work and we want to thank you very much for your interest and support and we look forward to telling you a lot about exciting news from other drugs in our pipeline in the coming months.
Ladies and gentlemen, that concludes today's conference. Thank you for your participation. You may now disconnect. Have a wonderful day.
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Justice Powell speaking at the dedication of the Powell Archives. April 4, 2014 marks the 22nd anniversary of this event.
Randall P. Bezanson, dean of the W&L School of Law from 1988 to 1994, died on January 25. He was 67. Randy's many accomplishments in those six transformative years included his planning and building the Powell Wing addition to the law school. This undertaking hinged on convincing Justice Lewis F. Powell, Jr., graduate of the college in 1929 and of the law school in 1931, to donate his personal and professional papers to the School of Law. Randy's considerable powers of persuasion prevailed, and Powell announced the gift in December 1989. In April 1992, the Powell Archives was dedicated and began welcoming researchers. The archives' almost 22 years of service to the scholarly community is an important part of Randy's legacy.
Guide to the papers
Spreadsheet guide to the Supreme Court Case Files
Supreme Court Case files in electronic format
Listing of Supreme Court Opinions Written by Powell (alphabetical)
Listing of Supreme Court Opinions Written by Powell (topical)
The Powell Memorandum
Selected Correspondence
Subject Files
Rare Book Collection
Laughlin, Charles Vaill, Papers, 1940-1983
Ritz, Wilfred J., Papers of, 1955-1985
Parker, Frank R. Papers, 1963-1997
Butler, M. Caldwell, Papers, 1972-1982; 1995-1997
Butler Additions
Tucker, John H. Papers 1916-1946
Sharp, Stephen Papers, 1969-1980
Ray, Robert W., Papers, 1994-2001
Powell, Lewis F. Collection, 1937-1999
Washington and Lee University School of Law Collection
Davis, John W. Collection, 1888-1953
Tucker, Henry St. George, 1874-1933
Powell, Josephine Rucker, 1929-1996
Clarke, J. Calvitt, 1943-1999
Hoffman, Walter E.. 1954-1992
Compton, A. Christian, 1974-2001 (unprocessed; contact the archives)
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Contact the archives at:
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Video Assisted Informed Consent for Lortab to Improve Patient Satisfaction and Knowledge
This study is enrolling participants by invitation only.
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ClinicalTrials.gov Identifier:
First received: June 7, 2011
Last updated: June 14, 2011
Last verified: June 2011
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No Study Results Posted on ClinicalTrials.gov for this Study
Study Status: | This study is enrolling participants by invitation only. |
Estimated Study Completion Date: | January 2012 |
Estimated Primary Completion Date: | September 2011 (Final data collection date for primary outcome measure) |


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True: Delly Pattison likes surpresents (presents that are a surprise). The day the Boyds come to town, Delly's sure a special surpresent is on its way. But lately, everything that she thinks will be good and fun turns into trouble. She's never needed a surpresent more than now.
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Katherine Hannigan's first novel, Ida B . . . and Her Plans to Maximize Fun, Avoid Disaster, and (Possibly) Save the World was a New York Times bestseller, a Book Sense bestseller, and a Parents' Choice Gold Award winner. She lives in northeastern Iowa.