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Publications (3)6.68 Total impact
- [show abstract] [hide abstract]
ABSTRACT: Several lines of evidence suggest that estrogens influence the development of osteoarthritis (OA). The aim of this study was to explore the association of two common polymorphisms within the aromatase (CYP19A1) and estrogen receptor (ER) alpha (ESR1) genes with severe OA of the lower limbs. The rs1062033 (CYP19A1) and rs2234693 (ESR1) single nucleotide polymorphisms were genotyped in 5528 individuals (3147 patients with severe hip or knee OA, and 2381 controls) from four centres in Spain and the United Kingdom. Gene expression was measured in femoral bone samples from a group of patients. In the global analysis, both polymorphisms were associated with OA, but there was a significant sex interaction. The GG genotype at rs1062033 was associated with an increased risk of knee OA in women [odds ratio (OR) 1.23; P=0.04]. The CC genotype at rs2234693 tended to be associated with reduced OA risk in women (OR 0.76, P=0.028, for knee OA; OR=0.84, P=0.076 for hip OA), but with increased risk of hip OA in men (OR 1.28; P=0.029). Women with unfavourable genotypes at both loci had an OR of 1.61 for knee OA (P=0.006). The rs1062033 genotype associated with higher OA risk was also associated with reduced expression of the aromatase gene in bone. Common genetic variations of the aromatase and ER genes are associated with the risk of severe OA of the large joints of the lower limb in a sex-specific manner. These results are consistent with the hypothesis that estrogen activity may influence the development of large-joint OA.Osteoarthritis and Cartilage 07/2010; 18(7):927-33. · 4.26 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: We report the results of the seventh edition of the GEP-ISFG mitochondrial DNA (mtDNA) collaborative exercise. The samples submitted to the participant laboratories were blood stains from a maternity case and simulated forensic samples, including a case of mixture. The success rate for the blood stains was moderate ( approximately 77%); even though four inexperienced laboratories concentrated about one-third of the total errors. A similar success was obtained for the analysis of mixed samples (78.8% for a hair-saliva mixture and 69.2% for a saliva-saliva mixture). Two laboratories also dissected the haplotypes contributing to the saliva-saliva mixture. Most of the errors were due to reading problems and misinterpretation of electropherograms, demonstrating once more that the lack of a solid devised experimental approach is the main cause of error in mtDNA testing.Forensic science international. Genetics 04/2008; 2(2):126-33. · 2.42 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: A collaborative work was carried out by the Spanish and Portuguese ISFG Working Group with a PCR multiplex for X chromosome STRs. Markers were selected among those described as polymorphic in humans and that have been used by some laboratories in forensics. Primers and various technical methods were investigated with the aim of optimizing a multiplex for the 10 selected X-STRs. Primer mix stock solutions were sent to the laboratories that were asked to analyse two female bloodstains, taking as reference the genetic profiles from 9947A, 9948 and NA3657 samples. In this work, we report the results obtained by 30 GEP-ISFG laboratories, using this Decaplex, as well as alternative technical conditions that also produced good results.Forensic Science International Genetics Supplement Series 01/2008; 1:677-679.
Publication Stats
19 | Citations | |
167 | Downloads | |
368 | Views | |
6.68 | Total Impact Points | |
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Instituto de Investigación Sanitaria de Santiago de Compostela
Santiago, Galicia, Spain


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Popluar Bandipur Hotels
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Bandipur National Park is one among the best natural reserves in India that is sprawling 874 square kilometers of lush green forest nurturing several species of animals and vegetation that is unique t moreLocation
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- * 4 Km From Railway Station.
- * 4 Km From Bus Station.

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text: I started laughing this morning when I saw Apple.com homepage stating that hell has frozen over announcing the release of iTunes for Windows. :) Has anyone tried it on their PC yet? Im downloading now for the PC. What is it missing that the Mac version has or are they identical?


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DescriptionFool's Rush climbs a series of corners to the right of the Maiden Buttress. Follow the corner system over flakey and blocky rock to an overhang. Pass the overhang on the left and belay below another overhang. Turn the overhang on the right and continue up broken rock to a nice ledge on the right. Move up and left to join White Maiden's Walkaway for the final pitch. LocationFool's Rush follows a corner system on the right side of the White Maiden Buttress. ProtectionSmall nuts and cams to 3 inches. Numerous runners.


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dc.contributor.advisor | Erskine, Toni | |
dc.contributor.author | Iosif, Kovras | |
dc.date.accessioned | 2008-10-21T15:05:23Z | |
dc.date.available | 2008-10-21T15:05:23Z | |
dc.date.issued | 2006 | |
dc.identifier.uri | http://hdl.handle.net/2160/689 | |
dc.description.abstract | Although institutional (moral) responsibility constitutes a critical component of contemporary international politics, it remains an uncharted field of inquiry in the field of International Relations. The primary objective of this dissertation is to put forward a theoretical argument upon which to build a theory of institutional responsibility, which will enable us to critically evaluate the UN's moral responsibility in the world's deadliest conflict since World War II, namely the conflict in the Democratic Republic of Congo (DRC) which traces its origins in the "spill-over" of the Rwandan genocide in 1994. An analytical presentation of the background of the conflict and of the objectives and actions of the parties involved is vital in the effort to critically assess the UN's moral accountability in this conflict. Enquiries related to the UN moral responsibility, guarantee the efficient prevention of new holocausts or genocides in the future. Indeed the UN was primarily founded on the slogan "Never Again". Thus the theoretical engagement in this field has some very tangible and humanitarian implications. The critical stance towards the UN, adopted in this dissertation, is a constructive critique which has as primary objective the more efficient functioning of the UN in the future. | en |
dc.description.sponsorship | Aberystwyth University | en |
dc.language.iso | en | en |
dc.publisher | Aberystwyth University | en |
dc.subject | United Nations | en |
dc.subject | Genocide | en |
dc.subject | Rwanda | en |
dc.title | 'A Critical Assessment of the UN's Moral Responsibility in the 'Spill-Over' of the Genocide from Rwanda to the Democratic Republic of the Congo' | en |
dc.type | Text | en |
dc.publisher.department | International Politics | en |
dc.type.qualificationlevel | taught masters | en |
dc.type.qualificationname | MA | en |
dc.type.publicationtype | thesis or dissertation | en |


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DescriptionThis huge boulder just up the hill from the 'Peabody Boulders' is home to 'High Plains Drifter', a Dale Bard problem that is a must-do old-school classic. In addition, there are many other classic problems, especially on the North Face of the boulder. Getting ThereWalk up hill from the Peabody Boulders. 4 Total Routes
The ClassicsMountain Project's determination of some of the classic, most popular, highest rated routes for Drifter/Smoking Boulder:
Featured Route For Drifter/Smoking Boulder
High Plains Drifter V6-7 7A+ CA : Sierra Eastside : ... : Drifter/Smoking Boulder
Start with sharp patina crimps and make some long pulls slightly up and right to gain a couple of slopers. Make a dynamic move off the slopes to gain better holds and an easy, but airy summit. This problem is a North American classic and a must do for the visiting boulderer.As a note of trivia, John Sherman referred to this problem as a benchmark standard for V6 in the first edition of his Hueco guide when he initially introduced the V-scale. It has since crept up in grade. ...[more] Browse More Classics in CA
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Hoops: Non-Conference Schedule Preview | News | Men's Basketball | Cyclone Fanatic
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Nice work. Two corrections:
1) Hawk fans don't work in cubicles. They clean cubicles, but that happens at night.
2) We did not lose to Drake last year. I don't believe that we played them at all. You may think I'm swimming upriver here, but there was no Drake game last year.
Nice write up Chris. I just wanted to mention something. Campbell has former Cyclone Antwon Oliver this year. His 2 years at juco he was an All Conference selection and last year he averaged 15 pts and 7 rebounds.
Eric McKnight also plays for Florida Gulf Coast
Sorry, you are swimming the wrong direction bro, turn around.
Iowa State Cyclones Basketball 2011-12 Schedule - Cyclones Home and Away - ESPN


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This is an absolutely beautiful intricately beaded gown. I fell head over heels in love with it when I put it on. It's perfect for any bride—glamorous, classic, vintage. You will feel perfect in this gown.
- Label Size: 4
- Street Size: 4
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- Height with Shoes: 5'5
- Alterations: no alterations have been made
- Color: Ivory
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By wegburn
Seattle, WA
on November 05, 2011
This dish was not a big hit with my family. I agree with Jani321, the lemon rinds get really mushy and they aren't particularly appetizing. Overall the lemon flavor was just too pungent for me. If I ever make this again I would take the lemons out much earlier, or serve a few thin slices of lemon with the dish when serving.
I load the flavor combination. I served it over brown rice with the herbs and pine nuts.
I wonder if this was based on a dish that used preserved lemons. Perhaps I will try that next time.
I also extended the servings and upped the nutrition by adding a small can of chickpeas.
By Jani321
Parkin, AR
on September 26, 2011
Out of the other recipes in "The World in a Day," this one was my least favorite. The flavors were interesting, and I like the saffron, which made everything "pop," but the lemon rinds became very mushy as they cooked. Even when I tried to remove them, they fell apart, and pieces remained. Nothing (IMHO is worse than biting into a mushy lemon rind. Perhaps, if I was to make it again, I would remove the lemons after they cooked awhile (before they got mushy, and then add fresh ones right at the end for looks and to freshen the dish up a bit.
I thought the flavor of this dish were most interesting. It was a nice change with the lemons and olives and warm spices. I did not use the pine nuts (my family does not like them much, I would try this again
By ShanLeigh
Houston, TX
on May 27, 2011
I didn't think it was awful (I ate it, but wouldn't necessarily make it again, but the family HATED it. :-( I think it may have been the combo of olives and lemon. The couscous was good though.
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Needle Felted Ball Workshop
Date: Fri. October 11, 2013
Time: 10:00 am - 12:00 pm
Harold Washington Library Center
Innovation Lab, 3rd Floor
400 S. State Street
Program: Innovation Lab
About this event:
Join fiber artist Diane Johns for this hands-on needle felting workshop for beginners! Participants will learn the tools and techniques of needle felting, and will create their own uniquely designed wool ball.
Required: must be age 14 or older; must have basic computer and mouse skills; Chicago residents must have a Chicago Public Library card; others must present a photo ID. Please note that this program does not involve use of the machines in the Maker Lab.
Please be on time. No participants will be admitted later than 5 minutes after class has started.
Registration is required for this free event. Please go to http://cplinnovationlab.eventbrite.com/ or call 312-747-4400 to register.
Registration Required


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Welcome to our SAGE RIDGE SCHOOL team page!
EVENT: JDRF Walk to Cure Diabetes Date: Sunday,October 6th Location: UNR Time: 9:30 AM
Hi! My name is Alli Christy and I'm in the 6th grade class at Sage Ridge School. I am really excited that Sage Ridge School has a team at the JDRF Walk on October 6, 2013. I'd like to take this opportunity to educate Sage Ridge School's friends and family about Type 1 diabetes. With your support, the JDRF researchers will continue to provide better treatments and ultimately find a cure for me and all the other kids with Type 1 diabetes.
What causes TYPE 1 diabetes? Scientists do not know yet what exactly causes Type 1 diabetes. It is also known as juvenile diabetes or insulin dependent diabetes. Scientists do know that at this time it can't be prevented, there is no cure and TYPE 1 DIABETES is not caused by eating too much sugar!!!
What is the difference between Type 1 and Type 2 diabetes? T1D is much less common and often occurs in childhood. The youngest newly diagnosed child that I visited at the hospital was under 1 years old. Type 1 occurs when the body's immune system attacks and destroys certain cells in the pancreas, an organ that is about the size of a hand that is located behind the lower part of the stomach. Theses cells, called beta cells, normally produce insulin which is a hormone that turns sugar/glucose into engery for the body. When the beta cells are destroyed, no insulin can be produced. When this happens, glucose stays in the blood stream and causes serious damage to all the organs of the body. For this reason, kids with Type 1 diabetes need to take insulin to stay alive. You can't outgrow T1D but scientists think this may be the next disease cured!
Note: Type 2 diabetes is often caused by excess weight and inactivity(this is not the kind that I have!!). Type 2 is more common in adults and can be prevented with healthy lifestyle choices.
When was I diagnosed with Type 1 diabetes? I was diagnosed with type 1 diabetes on August 8, 2006. I was 4 1/2 years old. I had the following symptoms: thirsty, sudden weight loss, headaches, and frequent urination.
How has my life changed since I was diagnosed? I think about diabetes 24 hours a day. I test my blood sugar every few hours. If my blood sugar is low, I need sugar. If my blood sugar is high, I need insulin. Instead of shots, I choose to wear a small wireless machine(size of a pager) that gives me insulin. I am sure to count the amount of carbohydrates in my snacks and meals. I give myself 1 unit of insulin for about every 18 carbohydrates. Further, I often take into account many factors that are difficult to predict: sleep, stress, exercise, food digestion rates, hormones, etc. Although I am able to do everything on my own, my parents are always available to help me make decisions.
Note: I ate healthy before I was diagnosed, so my diet has not changed. I can do any activity that you can do...swim, ski, ride horses, camp, sleepovers etc.
How should you treat me or other kids with Type 1 diabetes? Just the same as anybody else. Some kids have asthma or allergies....some kids have Type 1 diabetes.
What are a few statistics on Type 1 diabetes?
40% of everyone in US carries one or more of the HLA genes which lead to an increases risk of Type 1
One in 400-500 people in the population develop Type 1, but 1 in 20(5%) are at risk if a first degree relative has Type 1.
80% of JDRF money raised goes direclty to research. Past and present research efforts help local kids like myself. There are new and improved insulin pumps, artificial pancreas(in outpatient trials-available in about 4 years!!), ....encapsulation, smart insulin, restoration-there are many amazing research projects in the works. I often wonder which one will ultimately become the cure!!!
Thanks so much for considering walking and/or donating to Sage Ridge School's JDRF team. With our commitment to research and your help, I know that there will be a cure for diabetes!!! Thanks so much for making JDRF one of the many important causes that you support!!!! Let's turn Type 1 into Type None!!!
Sage Ridge School....and Alli Christy, Age 11, team captain
Sage Ridge School (Alli Christy) | Raised |
Alli Christy | $2,115.00 |
Scott Christy | $0.00 |
Jody Covington | $25.00 |
Sarali Diaz | $30.00 |
Debra Handke | $200.00 |
Tyler Handke | $0.00 |
Eve Johnson | $150.00 |
Richard "Papa" Johnson | $100.00 |
Courtney Kiely | $180.00 |
Daniel Kiely | $0.00 |
Jennifer Kuehn | $235.00 |
Vivian Leal | $150.00 |
James McCarthy | $115.00 |
Anna Teressa (Tessa) Mendez Leal | $150.00 |
Kimmy Parker handke | $0.00 |
David Smith | $0.00 |
Jacob Smith | $0.00 |
Jennifer Smith | $250.00 |
Sarah Smith | $0.00 |
Emily Stevenson | $250.00 |
Sarah Stevenson | $0.00 |
Rick Welcome | $100.00 |
Team Gifts | $1,660.00 |
Denotes a Team Captain |


text:
Kathy Cassidy
First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.
Google is asking surfers with time on their hands to help it categorize and label the images indexed by its search engine, building a database of knowledge about the contents of the images.
The company launched a new online game on Friday, Google Image Labeler, which it describes as "a fun way to help us organize all the images on the Web." In the game, two randomly selected players are each shown the same image, plucked at random from Google's search index, and given 90 seconds to suggest as many keywords or phrases as they can to describe it. They score points if any of their descriptions match.
Google's image search engine currently returns results based on captions and other text adjacent to images on Web pages, without reference to the content of the images themselves. The game will allow it to improve the performance of the search engine by returning results based on the players' descriptions of the images.
The game is not the first attempt to use volunteer labor to create a database of knowledge: The Wikipedia online encyclopedia and the DMoz search directory two of the better known examples.
Google's game, based in part on technology developed at Carnegie Mellon University, is not even the first to use volunteer labor to categorize images: The ESP Game developed by Luis von Ahn and other researchers at Carnegie Mellon first put players to work tagging its image database in October 2003.
Building a database using information provided by volunteers has its risks: campaign groups or pranksters might influence or pollute the raw data by associating an insulting term with the image of a political candidate. The campaign to link the term "miserable failure" to the online biography of U.S. President George W. Bush at http://www.whitehouse.gov/president/gwbbio.html is one example of how this can happen.
The ESP Game and Google Image Labeler limit the possibilities for such pranks, since they select players and images at random, and only associate a label with an image if both players independently suggest it.
Von Ahn and his colleagues study "human computation," or finding novel ways to put human brains to work. Their work includes Peekaboom, a game which harnesses players' brains to locate objects in images, and Phetch, which goes further than the ESP game by inviting players to create longer descriptions of images. You can also blame them for Captchas, those puzzles featuring sequences of distorted letters that are intended to distinguish between humans and computer impostors.
Google says its search engine indexes billions of images. That may make Google's goal of labelling all the images on the Web seem far-fetched, especially since players of Von Ahn's game have only attributed around 17.8 million labels to images since October 2003, according to the game's Web site.
However, computer users around the world collectively wasted 9 billion hours playing Solitaire on their computers in 2003, Von Ahn estimated in a presentation to Google staff in July. If they had spent that time playing The ESP Game or Google Image Labeller instead, they could have labelled almost 200 billion images.
First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.
For work use, Microsoft Word and Excel programs pre-installed on the device are adequate for preparing short documents.
The Fujitsu LifeBook UH574 allowed for great mobility without being obnoxiously heavy or clunky. Its twelve hours of battery life did not disappoint.
The screen was particularly good. It is bright and visible from most angles, however heat is an issue, particularly around the Windows button on the front, and on the back where the battery housing is located.
My first impression after unboxing the Q702 is that it is a nice looking unit. Styling is somewhat minimalist but very effective. The tablet part, once detached, has a nice weight, and no buttons or switches are located in awkward or intrusive positions.
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We all the voices of our parents' bad choices
The aftermath of divorces, the kids of bitter split-ups
from Kanye West – Mama's Boyfriend Lyrics on Rap Genius
Even Kayne's harshest critics must commend his courage to confront themes that do not fall neatly into the mainstay of rap. His relatively affluent upbringing did not feat neatly in the "gangster" persona that dominated 1990s hip-hop, and his role was first confined to producing beats for others. Even after his found mainstream success and pioneered "backpack rap," he continued to experiment with new themes such as religion, consumerism, and isolation.
Here he's at it again.
To help improve the meaning of these lyrics, visit "Mama's Boyfriend" by Kanye West Lyrics and leave a comment on the lyrics box


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- Fans Can Get Complete IMS Information From New Mobile App
May 10, 2013 | By Paul Kelly
Fans Can Get Complete IMS Information From New Mobile App
Indianapolis Motor Speedway fans can get complete, up-to-the-minute information about events at the Racing Capital of the World anywhere and anytime through a new IMS mobile app.
The free Brickyard Mobile app is available for Apple devices through iTunes and for Android devices through the Android Market and Google Play.
Many features are included on the app, such as ticket purchasing, event schedules, photos, news feeds, race results, track maps with key points of interest, Know Your Zone parking information and much more.
"More and more people are using mobile devices as their primary source of connectivity, and this app will deliver the most important and requested information about IMS to our fans," said Jarrod Krisiloff, IMS senior director of marketing. "This clean, effective new app will create an even stronger connection between the Speedway and its events and the fans."
Fans using the Brickyard Mobile app automatically will receive updated information on their mobile device, such as schedules, track action reports and more.
Vital information, such as maps and schedules, also are stored within the app so fans can access it even without mobile connectivity.
All information available in the Brickyard Mobile app also is available at the IMS mobile-optimized website, m.indianapolismotorspeedway.com.
2013 Indianapolis 500 tickets: Tickets are on sale for the 97th Indianapolis 500 Mile Race on Sunday, May 26 at IMS.
Race Day ticket prices start at just $30. Fans can buy tickets online at www.ims.com/tickets, by calling the IMS ticket office at (317) 492-6700, or (800) 822-INDY outside the Indianapolis area, or by visiting the ticket office at the IMS Administration Building at the corner of Georgetown Road and 16th Street between 8 a.m.-5 p.m. (ET) Monday-Friday.
Children 12 and under will receive free general admission to any IMS event in 2013 when accompanied by an adult general admission ticket holder.
Tickets for groups of 20 or more also are on sale. Contact the IMS Group Sales Department at (866) 221-8775 for more information.
- Thu, March 06
IMS Taps Levy Restaurants As Concessions Partner - Fri, February 21
Fans Encouraged To Share Favorite IMS Memories - Fri, February 14
Tired of Winter? Get Ready For The Grand Prix of Indianapolis With Simon Pagenaud - Thu, February 13
IMS Month of May Bronze Badges Now On Sale - Fri, February 07
Grand Prix of Indianapolis Trophy Design Winner Dan Nichols - MORE HEADLINES


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Kukla's Korner Hockey
The NHL Hour with Luke Schenn & Drew Doughty
by Alanah McGinley on 01/22/09 at 05:30 PM ET
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Rookie sensations Luke Schenn (Toronto Maple Leafs) and Drew Doughty (Los Angeles Kings) are guests on today's edition of NHL Hour with Commissioner Gary Bettman.
The show is on from 4-5 p.m. ET on XM Satellite Radio (204) and Sirius (208).
You can also listen live online at the NHL Network Online once the show starts.
* While on the air, listeners can call into the show at 1-877-645-6696, or send questions/comments via this email address: firstname.lastname@example.com
**Archived shows available for download via podcast on NHL.com.
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Spring showers may bring May flowers, but I wish we could have just a bit more sunshine this time of year! Raincoats never seem to be on the top of my clothes shopping list, but they're essential especially in the spring. We found a few fashionable options, which means you won't have to sacrifice your style in the rain. Keep reading to see our 6 favorites (and some serious deals too!)…
Colorblock Poncho1. Colorblock Poncho
Hello colorblocking! It might be rainy but these spring colorblocked colors are super cheery!
Get it here
Double Breasted Trench2. Double Breasted Trench
Slim fitting, this fashionable trench raincoat is such a popular style this season. The great neutral color will compliment any outfit.
Get it here
Related: Our 20 favorite picks in spring's hottest color ... mint green
Hooded Ripstop Poncho3. Hooded Ripstop Poncho
Ponchos (i.e. capes) in all varieties are so hot this season. This one will be fashionable and keep you nice and dry.
Get it here
Hooded Ripstop Raincoat 4. Hooded Ripstop Raincoat
We love this version with fun purple and green colors and complete with a hood. A great price too! Although, I would ahem, recommend wearing a little more layers under mine.
Get it here
Related: 17 fashion trends that need to disappear
Michael Kors Hooded Cape5. Michael Kors Hooded Cape
This Michael Kors cape is in a gorgeous rose color and has a beautiful cut ... perfect for spring showers.
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Neon Parka6. Neon Parka
This bright neon parka will surely shine those rain clouds away.
Get it here
- By Liz Stanley
Follow Liz on Babble
For 4 more stylish raincoats for spring, visit Babble!
15 new tankini trends to sport this summer
21 must-have items for your spring wardrobe
23 ways to wear yellow skinny jeans
The Budget Fashionista - 20 stylish picks from Forever 21
28 funky ways to wear neon
Stay connected. Follow Babble on Facebook and Twitter.
Sleek Slickers: 6 Stylish Raincoats for Spring
By Babble.com | Fashion – Wed, Mar 21, 2012 4:28 PM EDTMOST POPULAR
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The beefy one is sexy, in a "will you please hold still? Just hold still, that's all. Dammit, hold still" kind of way.
Mike ("The Situation")
Pauly D
The beefy one is sexy, in a "will you please hold still? Just hold still, that's all. Dammit, hold still" kind of way.
Well, I think you've just described at least half of the gay community. There are plenty of guys featured here that are the way you've described and no one seems to have a problem with them. Excuse me but I think some of you all have biased opinions. I know nothing personally about the beefy Latino(assuming he is Latino) guy I've previously mentioned but he is not ugly. I've certainly witnessed people gushing over less attractive people that have been mentioned on JUB.
Hell yeah, all y'all need to stfu- you know you would fuck mike. I know I would, i dont know why Pauly D wasn't in this photoshoot, hes the one im after :P
Agreed!!! These boys are fuckin S E X X X !!! They all make my dick so hard!!! I'd nut over all their titties for sure!!!
"As for the Village Voice SitUAtioN - it's not for me to judge somebody's sexual preference and in my opinion the SitUaTIoN looks good as hell and that is my main concern. It just so happens that The SitUaTiON has mass appeal and happily reaches a very broad audience - This is not my first cover and definitely not my last - SitUATIon NATION"
~ Mike The Sitch via Facebook.
You guys are too quick to judge. If you actually watched the show, you'd know that only Mike is a douche, and even he can be nice sometimes. I think they're all great guys and extremely hot
Uh, dear god no, he hasn't. He may have described half of the media depiction of the gay community, but not everyone gets an orange tan and takes hours to do their hair around these parts.
He's Italian, and he's not bad. It's the other two that i don't find attractive - and that's on personality alone. No, i would NOT fuck them if the opportunity arose, no i would not hang with them if they offered. I don't have a bias - i know what i like, and someone that's an attention whore(Mike, at least) born out of "M"TV rings in the "don't like" column. As to who's more or less attractive? That's subjective.
vinny is the cutest..bbut i still wanna be banged by ronnie
I don't find any of them attractive
And their personalities make them pretty disgusting.
I don't find ANY of them attractive. But the one that looks like a lizard with a blowout isn't featured, so that's great.
Damn, Pauly D isnt in it. He's the hottest
The situation really is looking pretty homo-ish in the pic of him on the table. I have never watched this show and have zero intentions of doing so but all I will say is that paper bags are made for the likes of the situation. Great body but that face just needs to go
The dude in the glasses was the finest on the shoe, the rest of them are pretty fugs :s
amazing men!! I wish they had Pauly D.... and when is his Playgirl shoot?
The Situation should work more on his lower body than upper. He looks like a tooth-pick downstairs. I bet he has no butt.
The rest are just as gross. The only one that's semi-cute is Ronnie.
gross.... like wtf?
Too quick to judge - you are kidding, right? These guys are so lame they make lame look appealing. They are all douche bags with the filling. This proves anyone can be a celeb.
I watched a few episodes of the first season and was so appalled at their antics and morals and sleaziness - and I include the girls in that, too. Dregs.
A N D I wouldn't put my mouth on one of their skanky dicks for fear of catching numb nuts and every std known to man.
Last edited by joesman; June 25th, 2010 at 09:03 AM. Reason: to add another dish.
I think you mistake me for someone who cares.
No, none of them are doing it for me. They look too vain.
Haha, of course that douche doesn't care - he's an attention whore and these photos probably got him on E! News or some shit for a few seconds. I've never seen this show (and the only time I'm even aware that these goons exist is when they pop up on something else here and there) - but from what I do know, it seems they're walking parodies of themselves and would do anything for fame/notoriety....Yeah, pretty much the American standard. Don't bitch and whine about them if you're watching even a second of that ridiculous show; YOU made THEM.
Regarding the original topic, I think it's hilarious if they got "tricked" into posing for a gay magazine. Especially since they look extremely gay in those shots (and I mean "gay" in the same context that those toolboxes probably use on a daily basis).
Read my blog HERE *NSFW*
They may be kind of dumb, but they turn me on! Vinny and Pauly D (not pictured in the magazine) are the hottest ones!
For the record, I think too many people gay, bi, straight, indifferent have fake tans but it's their bodies. They can do as they wish just as I prefer to be a pasty white, sort of anemic looking boy.
My mistake. Italian...now, I find him even more attractive.
I don't understand how they were "tricked." The Situation's baby tee should've been a dead giveaway.
These guys are NYers and a bit grown up not to know about the Village Voice....give me a break no one was tricked
I wish they had been tricked into a Playgirl shoot or an underwear wrestling match.
Tricked into it? Yeah, right, ok. HAHAHAHAHAHAHAHA
They all seem to be douchebags but I'll admit I want to give the situation a tonguebath.
Since they did the Village maybe they can just go ahead and pose naked for Playgirl, that will be hot!
Ok so to use the term celebrity is stretching it a lot but for those that watch this trainwreck... The last episode had Ronnie getting out of his gfs bed with morning wood. Thats my contribution to society for the day... (no clue how to do screen prints)
i noticed that last week too! he was trying soo hard to hide it but i just wasn't happening lol
here are some blurry pics...and i found a video but i can't link it cause I don't have 25 posts yet..but just copy and paste!
He has a Prince Albert. I thought he was cute until he he was making out with someone in season 1 and she wanted to see it. No. My standards may stoop to low levels sometimes but these guys and the pits of low level. the girls, too.
I think you mistake me for someone who cares.
According to the girls, he has a HUGE penis! We need some to find pictures to prove it!
I'm sure Ronnie knows how big his dick is.
On the second season opener there is a point when Ronnie is reunited with the house and he is cornered with Vinnie in a doorway. Vinnie keeps asking him if he is glad they are "sharing" a room and Ronnie says yeah cause he's with Vinnie... The camera goes slightly up and out of the money shot but its clearly there_ Ronnie says "gimme some cock" and grabs Vinnie's dick then kinda looks around to see if any of the cameras' caught it.
I could not believe what I was witnessing it is totally hot! Check it out... I showed someone else and they too could not even believe it was not edited out...
I saw the same thing tonight. It owuld be nice to know how long it really is. I am sure he had no problem hooking up earlier, but this will make it even easier for him to find girls who are DTF.
MTV could make a ton of money if they would sell the footage of the housemates having sex with all of the random people they bring back.
Is Vinny the short one with the big tits who was recently arrested?
Well Snookie said it was huge. She's a midget. I'm guessing he's average to us and just the first guido she's had sex with who's junk doesn't look like it was stuck in a hot dryer for 7 hours because of all the steroids they take.


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edited 5/20: These charts are not professionally researched or produced. Please take their findings with a grain of salt. Thanks. Last year, I started a series of infographics about YA book covers, mostly as a tongue-in-cheek reaction to the Wall Street Journal's "Darkness in YA" controversy.
Kate Hart: Uncovering YA Covers: 2011
More than 60,000 ballots were cast in our annual summer reader's survey — click here to see the full list of 100 books, complete with links and descriptions. Below is a printable list of the top 100 winners. And for even more great reads, check out the complete list of 237 finalists. 1.
Top 100 Science-Fiction, Fantasy Books
My shelfari


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The FAO Dairy Price Index - February 2014The FAO Dairy Price Index averaged 275.4 points in February, a rise of 7.7 points, or 2.9 percent, over January. Demand for all dairy products remains firm, especially from North Africa, the Middle East (SMP and WMP) and the Russian Federation (butter). Limited supplies have lent support to prices, with the index currently standing 31.3 percent above its level in February 2013. Mild weather in some regions of Western Europe has provided the basis for a strong start to the 2014/15 season, which will only peak in April-May. Meanwhile, export supplies in Oceania remain limited.
Dairy Outlook List - free subscription!The Dairy Outlook List is a network to facilitate the exchange of information on developments in the world's dairy industry between list members.


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I make this every time I make a holiday ham to use up the leftovers. It smells so wonderful as it cooks and pleases even the so-called pea haters in my family. Simple to prepare too..just chop all your veggies and ham up and toss everything into the pot and cook. No need to soak the peas overnight..just a rinse and drain before cooking.
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Servings Per Recipe: 10


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You are here: Home » Canadiens vs Wild – March 1/12
Minnesota Wild goalie Josh Harding reaches for the puck as Montreal Canadiens right wing Brad Staubitz (left) and Minnesota Wild defenseman Kurtis Foster struggle during NHL action at the Bell Centre in Montreal Thursday March 1, 2012. (Allen McInnis / THE GAZETTE)
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Christian Living
We all want to lead a Christian life filled with faith, love and joy - but sometimes we need a little help. Find Christian advice in the wide selection of books offered by Family Christian, and get the tips you need to ensure that your relationship with Christ and those around you is flourishing.
Godchicks and the Men They Love
Holly Wagner, Philip Wagner
$14.99Add Your ReviewIn GodChicks and the Men They Love, Holly and her husband, Philip, offer couples seeking to live up to their full, God-intended potential a guide for growing together into all they are meant to be. Philip writes that "men need to do what only men can do so that women will be... Learn More -
Warrior Chicks: Rising Strong, Beautiful & Confident
Holly Wagner
$14.99Add Your ReviewAuthor of best-selling "GodChicks," Holly Wagner identifies and encourages the cultivation of aspects of the WarriorChick within every woman who is destined to be an overcomer - a woman who rises up in the face of the challenges of life. Learn More
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Pontypridd go into the final two matches of the league season proper with two long haul trips down to West Wales. Successive away games at Llanelli and Llandovery will be crucial to the ultimate success of the club's Premiership campaign.
Success in both missions will depend on team spirit, and if recent experiences are anything to go by, that team could be made up of a thousand plus willing souls!
The Ponty squad and management have continually paid tribute to the fantastic support that follows them to all venues, in all weather, at any time of day and night. That support will be needed again to back the team at Llanelli and Llandovery in a final push to maintain pole position in the table prior to the Premiership Play-Offs.
The Pontypridd RFC Supporters' Club are organising coach travel to both venues – Parc y Scarlets, Llanelli on Thursday evening 14th April, and Church Bank Llandovery on Tuesday evening 19th April. The buses will depart Sardis Road at 5:45pm on both occasions.
To make a booking or for further information please call Phil Lycett on: 01443 662561.
club rugby
Total votes 1139
Sut y gallwn hawlio yn ol ein gem genedlaethol? Oes angen newid y strwythur?
How can we reclaim our national game? Is there a need for a restructure?
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Heeeeeeeyyyyy folks, how are ya? Welcome to this latest episode of the Space Game Junkie Podcast! This week, Jim and I don't have a guest (MUAHAHAHAHAH!), so we talk about 4X games, my fascination, and Jim's current fatigue with 'em. We also talk news and a few other things, but we're surprisingly more on-point than we usually are without a guest. ;)
Podcast: Play in new window | Download
As always, we look forward to your comments below, invite you to subscribe to us through RSS or iTunes, and thank you so much for listening. Enjoy!
Continue reading "SGJ Podcast #24: 4X Fatigue, Fascination & Frivolity" »


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Medieval Studies Program Annual Graduate Student Conference
Professor Steven Justice, professor of English at UC Berkeley, will serve as keynote speaker at this two-day conference on medieval studies.
When: Friday, May 17, 2013, 12:30 p.m. to 5 p.m.
Where: HSSB -- UCSB, Santa Barbara
Cost: Not available
Age limit: All ages
Categories: Lectures
The theme of this year's conference is, "Says Who? Contested Spaces, Voices, and Texts". Since Henri Lefebvre's 1958 The Social Production of Space, medieval scholars have been increasingly interested in the interplay between the political, the economic, and the cultural with regard to physical space. How is space constructed by social forces, and how is society influenced by either physical or ideological spaces? More specifically among these social forces, our conference focuses on the concept of authority: who determines how political, cultural, and economic processes take place within a specific space, and how they are spoken of, written of, and remembered? This two-day event will feature various panels, a performance of medieval farces, and a keynote presentation by Professor Steven Justice, all of which offer an interdisciplinary and cross-modal window into the construction and contestation of medieval authority across spaces, voices, and texts. Please see the conference website for a full schedule of events.
Sponsored by Center for Portuguese Studies, the Dept. of English, the Dept. of French and Italian, the Dept. of History, the Dept. of Religious Studies, the Dept. of Spanish and Portuguese, Graduate Division, the Medieval Studies Program, the Society for the Study of Medieval Languages and Literature, and Translation Studies, and the IHC.
Website: http://ucsbmedievalstudiesgrad.wordpress.com
Phone: 805-893-2004
Event posted May 13, 2013
Last updated May 13, 2013


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This game against Grand Rapids tomorrow is CRUCIAL. They will need to get Latta on the ice as much as they can because these are the hockey clubs that you need to beat down the stretch.
News and notes on the Milwaukee Admirals hockey team.
Free stuff!
Here's the release from the Admirals on their promotional highlights of the weekend, including a Christmas ornament.
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If they can get the "Big Three" together on the ice while Conner is taking a breather, they need to take advantage.
Conner does not scare me NEARLY as much as Nyquist does at this point. The last time I saw Conner out on the ice, he looked slow and it almost looked like his skates had toe-picks (I don't know why). I hope they can cut down on the penalties and hold these skaters in check. The Admirals have allowed the fewest goals in the league (well, they are tied but they are leading the conference which is what matters most) and that is what all their success is built on.
It would have been nice if their coach wouldn't have been PLUCKED so early but that is the nature of this business.


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Feel like home at our free ringtones website, where you may aquire epic ringtones for your cell phone. Today we have a ringtone of "Find Yourself" by John O Callaghan as well as 19 other ringtones by John O Callaghan. "Find Yourself" is a hit from the "State of trance" album that was produced by John O Callaghan at their studios together with other 1 tracks. You can listen to all 5 John O Callaghan – "Find Yourself" ringtone variations available here and download it for free to your hard drive. You can also choose from other 4 albums produced by John O Callaghan for all time. "Find Yourself" is referred to Progressive Trance, and we can offer you a huge amount of Progressive Trance videos absolutely for free. And finally, we have collected lyrics for this track and you can view it here as well. So feel free to browse, listen, download ringtones at Audiko.net. Make your phone sound cool!
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- hey hey - v


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Michelle explains that she adapted the muscle t-shirt and baggy pants. Nina doesn't think that it's strong enough for an editorial shoot. She reminds Michelle that she said verbatim that she didn't want a t-shirt and pants. Michelle cops to having made exactly the opposite of what Nina asked. Nina says that Michelle needs to employ a little bit of fantasy. I'm fantasizing about her getting kicked off of the show right now.
Backstage, we hear a Michelle interview where she says that she is feeling really emotional right now. Patricia is confident that she is going to be eliminated. The judges confer and Nina points out that Michelle completely ignored her instructions. They love that Layana was inspired by the Hearst Building. They like that Stanley's design has multiple pieces. They are kind of mixed on Daniel's look but ultimately approving. They are still interested in Patricia's work, even though she faltered on this challenge.
The designers return to the stage. Stanley wins the challenge! Jordana says that she is excited to wear his design. Layana is in. Daniel is in. That leaves Patricia and Michelle. Backstage, Layana says that she thinks it's going to be Patricia that goes. I guess we're not going to mention her absurd behavior from last week at all? Fine. Patricia is...in. She is crying when she gets backstage and says that she is in. Layana is such a dick and acts like she's almost upset because of the thought of Michelle being out. Michelle is not out though. Heidi tells her that she is getting a "do or die" moment. She is being sent home, but she will get one more shot to be a part of the competition. She, and we, will find out about that later. What a little bitch, she goes backstage and when people try to hug her, she says that she doesn't want to be touched and they should all just give her some space. I'm ready to give her all the space that she needs. Forever.
Jeff Long is a writer/performer in Brooklyn. He can be reached at firstname.lastname@example.com and followed on Twitter at @jblong.


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Skin care
6 Reasons to Eat Brunch at Home
These healthy (and wallet-friendly) recipes will completely change the way you think about your weekend mornings
Pancake Directions:
1. Put all ingredients in a large mixing bowl, heat stove to medium heat.
2. With a hand blender or food processor, mix ingredients together until thick and creamy. Place mixture into the fridge to rest.
3. On a square of paper kitchen towel add a cap of oil, and wipe it over the pan, put pan on stove and wait a few minutes till heated.
4. Using a large table spoon, spoon amounts of pancake mixture one at a time and cook, as one side starts to form and brown, flip it over and keep checking pancake until at desired form.
5. Once cooked transfer to serving plate.
Salmon Directions:
1. In a bowl mix together capers, juice of lemon and limes, tequila, triple sec, and olive oil. Whisk together, cover and place in fridge.
2. Place scallion pancakes on a serving dish.
3. With a sharp knife, slice thin strips of the salmon and place them over the scallion pancakes.
4. Sprinkle the salmon with the cilantro leafs.
5. Take out the Tequila mixture from the fridge and with a teaspoon, sprinkle the mixture over the salmon.
6. Serve with a light sprinkle of sea salt and crushed red pepper.
SEE NEXT PAGE: Crab, Mango, and Avocado Scrambled Eggs
Older comments
I would just like to point out that the first recipe calls for 2 1/2 cups of FLOWER
by sportimonki13 Sunday, February 17, 2013 at 05:20PM Report as inappropriate
I love these! I've been cooking brunch every weekend, and I definitely need new ideas!
by schien Sunday, February 17, 2013 at 10:30AM Report as inappropriate
I'll have to try some of these recipes!
by yestfl Saturday, February 16, 2013 at 06:58PM Report as inappropriate
Anything with asparagus in it, is for me!! #YUMMM
by Backinaction86 Thursday, February 14, 2013 at 10:07AM Report as inappropriate
Asparagus Soufflé sounds yummy:)
by mlira Thursday, February 14, 2013 at 05:27AM Report as inappropriate
home cooked food is the best! thanks for the recipes!
by venenumletalis Wednesday, February 13, 2013 at 06:32PM Report as inappropriate


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Norman fixates on the death of Miss Watson. The economic livelihood of the motel is threatened when Norma gets unexpected news about the bypass project. Bradley's hunt for her father's killer drives her to dangerous extremes. watch
Norman Bates is new in town. Watch this teaser of A&E's new series Bates Motel, the contemporary prequel to the genre-defining film 'Psycho.' Catch the premiere Monday, March 18 at 10/9c, only on A&E.
Check out the trailer for A&E's new Drama Series, Bates Motel, Premieres March 18th, 10/9c.
Take a look inside Episode 110, Learn from the writers and actors just how far Norma would go with her back up against the wall, and uncover how Sheriff Romero's moral compass guides the inner workings of the town. Also, hear the writers' thoughts on Norman's behavior in the final moments of the season finale. Watch More: http://www.aetv.com/bates-motel/ Facebook: http://www.facebook.com/BatesMotel Twitter: https://twitter.com/InsideBates
A Good Year movie trailer - starring Albert Finney, Russell Crowe, Marion Cotillard, Valeria Bruni-Tedeschi, Tom Hollander, Abbie Cornish. Directed by Ridley Scott. Theatrical Release Date: 11/10/2006 Genre: Drama Rating: PG-13
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Fatalistic teenager George Zingavoy (Freddie Highmore) is a master at just barely getting by. In fact, he's practically turned it into an art formmaking it through the entire school year without doing a shred of work.
Blast off with Astro Boy, the thrilling tale of a true hero! In futuristic Metro City, scientist Tenma (voiced by Nicolas Cage) creates an amazing robot boy with hidden talents unlike anything you've ever seen.
Fatalistic teenager George Zingavoy (Freddie Highmore) is a master at just barely getting by. In fact, he's practically turned it into an art form—making it through the entire school year without doing a shred of work. But when George meets a beautiful and complicated girl named Sally (Emma Roberts), he discovers a kindred spirit who turns his slacker world upside down. Their quirky and unexpected romance may just inspire George to do the unthinkable—get off his butt and chase after his dreams.
George, a lonely and fatalistic teen who's made it all the way to his senior year without ever having done a real day of work, is befriended by Sally, a popular but complicated girl who recognizes in him a kindred spirit.
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Norman fixates on the death of Miss Watson. The economic livelihood of the motel is threatened when Norma gets unexpected news about the bypass project. Bradley's hunt for her father's killer drives her to dangerous extremes. Also Available On Amazon Instant Video, A&E and VUDU
Go behind the scenes at the Bates Motel, and hear from the cast and creators why Season 2 will be bigger, more exciting and more dramatic.
Romero decides that it is time to act and Norman takes Emma to the dance. Miss Watson gives Norman a ride home. Also Available On Netflix, Amazon Instant Video and VUDU
Abernathy amps up the pressure, but Norma doesn't know what he wants. Dylan and Bradley connect. Norman has an active imagination, which Miss Watson encourages. Emma goes on a trip. Also Available On Netflix, Amazon Instant Video and VUDU
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It's gonna be a bright, sunshine-y day on Season 2 of Bates Motel — at least temporarily. When the second season of the A&E drama kicks off (Monday, 9/8c, A&E), four months have passed. It's summer in White Pine Bay and Norma Bates (Vera Farmiga) can't hold back the smile that comes from having her motel completely booked. But there's one cloud that Norma just can't shed: Norman (Freddie Highmore) remains fixated on the death of his teacher Miss Watson, whose grave he visits far too often for Norma's liking.Winter TV: Check out all the must-see new showsOf course, all signs in the Season 1 finale suggested it was Norman, distraught from a terrible night at a school dance and vulnerable after being shown affection by Miss Watson, is responsible for his dear teacher's death. Or is he?"The story of what happened to Miss Watson is very much, at this point, a story of perception," executive producer Kerry Ehrin tells TVGuide.com. "We saw [everything] through Norman's point of view at the end of the last season, and this season, we unravel that.... read more
A&E certainly has an eye for talent, with the brooding Chloë Sevigny joining the electrifying Vera Farmiga in back-to-back Monday psycho- (or Psycho) dramas. Unfortunately, the former Big Love scene-stealer is not nearly as well served by the unpleasant formula dreariness of Those Who Kill (10/9c), an adaptation of a Danish series that takes a by-the-numbers approach to some truly ghastly serial-killer action.
The sun is sinking behind Bates Motel's Vancouver set as cameras prepare to shoot Norma Bates (Vera Farmiga) scaling the familiar stone steps leading up to her iconic hilltop home. Spying an approaching flock of crows, the director instructs Farmiga to "wait for the birds" to enter the frame before commencing her ascent. At this point, one half expects the silhouette of ... read more
In its second season, A&E's Bates Motel will introduce the infamous fruit cellar where Mother's stuffed body...
Summer is here and school is out! But like any good teacher, we have assigned some homework. (Don't worry, the beach will still be there tomorrow.)With more great TV than ever available in so many different places, it's easy to miss a show or two. Below, we've hand-picked a dozen that you might not have noticed or simply didn't have the time for during the regular TV season. But they deserve your attention. Behold the 12 shows you should catch up on this summer:
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PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway
Cell Metabolism, Volume 14, Issue 5, 2 November 2011, Pages 598-611
Shinichi Oka, Ralph Alcendor, Peiyong Zhai, Ji Yeon Park, Dan Shao, Jaeyeaon Cho, Takanobu Yamamoto, Bin Tian and Junichi Sadoshima
SummaryHigh energy production in mitochondria is essential for maintaining cardiac contraction in the heart. Genes regulating mitochondrial function are commonly downregulated during heart failure. Here we show that both PPARα and Sirt1 are upregulated by pressure overload in the heart. Haploinsufficiency of either PPARα or Sirt1 attenuated pressure overload-induced cardiac hypertrophy and failure, whereas simultaneous upregulation of PPARα and Sirt1 exacerbated the cardiac dysfunction. PPARα and Sirt1 coordinately suppressed genes involved in mitochondrial function that are regulated by estrogen-related receptors (ERRs). PPARα bound and recruited Sirt1 to the ERR response element (ERRE), thereby suppressing ERR target genes in an RXR-independent manner. Downregulation of ERR target genes was also observed during fasting, and this appeared to be an adaptive response of the heart. These results suggest that suppression of the ERR transcriptional pathway by PPARα/Sirt1, a physiological fasting response, is involved in the progression of heart failure by promoting mitochondrial dysfunction.
Summary | Full Text | PDF (2562 kb) - Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis ...
Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
Cell Metabolism, Volume 9, Issue 4, 8 April 2009, Pages 327-338
Aparna Purushotham, Thaddeus T. Schug, Qing Xu, Sailesh Surapureddi, Xiumei Guo and Xiaoling Li
SummaryHepatic metabolic derangements are key components in the development of fatty liver, insulin resistance, and atherosclerosis. SIRT1, a NAD+-dependent protein deacetylase, is an important regulator of energy homeostasis in response to nutrient availability. Here we demonstrate that hepatic SIRT1 regulates lipid homeostasis by positively regulating peroxisome proliferators-activated receptor α (PPARα), a nuclear receptor that mediates the adaptive response to fasting and starvation. Hepatocyte-specific deletion of SIRT1 impairs PPARα signaling and decreases fatty acid β-oxidation, whereas overexpression of SIRT1 induces the expression of PPARα targets. SIRT1 interacts with PPARα and is required to activate PPARα coactivator PGC-1α. When challenged with a high-fat diet, liver-specific SIRT1 knockout mice develop hepatic steatosis, hepatic inflammation, and endoplasmic reticulum stress. Taken together, our data indicate that SIRT1 plays a vital role in the regulation of hepatic lipid homeostasis and that pharmacological activation of SIRT1 may be important for the prevention of obesity-associated metabolic diseases.
Summary | Full Text | PDF (1576 kb) - A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis
A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis
Molecular Cell, Volume 7, Issue 1, 1 January 2001, Pages 161-171
Ajay Chawla, William A. Boisvert, Chih-Hao Lee, Bryan A. Laffitte, Yaacov Barak, Sean B. Joseph, Debbie Liao, Laszlo Nagy, Peter A. Edwards, Linda K. Curtiss, Ronald M. Evans and Peter Tontonoz
SummaryPrevious work has implicated PPARγ in the regulation of CD36 expression and macrophage uptake of oxidized LDL (oxLDL). We provide evidence here that in addition to lipid uptake, PPARγ regulates a pathway of cholesterol efflux. PPARγ induces ABCA1 expression and cholesterol removal from macrophages through a transcriptional cascade mediated by the nuclear receptor LXRα. Ligand activation of PPARγ leads to primary induction of LXRα and to coupled induction of ABCA1. Transplantation of PPARγ null bone marrow into LDLR −/− mice results in a significant increase in atherosclerosis, consistent with the hypothesis that regulation of LXRα and ABCA1 expression is protective in vivo. Thus, we propose that PPARγ coordinates a complex physiologic response to oxLDL that involves particle uptake, processing, and cholesterol removal through ABCA1.
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Cell Metabolism, Volume 7, Issue 4, 302-311, 9 April 2008
Add/View Comments (0)Hepatic Steatosis in Leptin-Deficient Mice Is Promoted by the PPARγ Target Gene Fsp27
Kimihiko Matsusue1, 2, , , Takashi Kusakabe3, Takahiro Noguchi2, Shouichi Takiguchi4, Toshimitsu Suzuki3, Shigeru Yamano2, 5 and Frank J. Gonzalez1, 5
1 Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
2 Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
3 Department of Pathology, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima City, Fukushima 960-1295, Japan
4 Institute for Clinical Research, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka 811-1395, Japan
5 These authors contributed equally to this work.
- Peroxisome proliferator-activated receptor γ (PPARγ) is induced in leptin-deficient (ob/ob) mouse liver and is critical for the development of hepatic steatosis. The present study shows that fat-specific protein 27 (Fsp27) in ob/ob liver is a direct target gene of PPARγ and can elevate hepatic triglyceride levels. FSP27 belongs to the CIDE family, composed of CIDE A, CIDE B, and FSP27/CIDE C, all of which contain a conserved CIDE-N domain. FSP27 was recently reported to be a lipid droplet-binding protein and to promote lipid accumulation in adipocytes. The Fsp27 gene was expressed at high levels in ob/ob liver and at markedly lower levels in ob/ob livers lacking PPARγ. Forced expression of FSP27 by adenovirus in hepatocytes in vitro or in vivo led to increased triglyceride levels. Knockdown by adenovirus expressing FSP27 shRNA resulted in lower accumulation of hepatic triglycerides compared to control adenovirus-infected liver. Taken together, these results indicate that FSP27 is a direct mediator of PPARγ-dependent hepatic steatosis.


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Gaza Strip: Israeli soldier killed, two Palestinians wounded
An Israeli soldier was killed and two were lightly injured Thursday morning when a bomb exploded near them in the Bureij refugee camp in the central Gaza Strip. Palestinian witnesses said that some 10 tanks and two bulldozers backed by helicopters moved before dawn nearly 500 meters into farming fields near camp.
The Israeli forces were patrolling the area when an exchange erupted between them and Palestinian fighters.
During the fighting at Bureij, at least two Palestinians were seriously wounded by an Israeli airstrike on the scene, Palestinian medical staff and the army said, according to Reuters. An Israeli military spokeswoman said forces were operating in the area to "foil terrorist actions."
The Palestinian reports said the two wounded fighters were members of the Islamic Jihad.
Top Headlines
- Gaza Strip: Four Hamas members, three Israeli soldiers killed
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- Six Palestinians, Israeli soldier killed in Gaza Strip, Hebron
- Israeli strike kills two Palestinians
- Gaza Strip: At least one Palestinian killed by Israeli fire


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Pricing models
Under pressure from regulators and investors, hedge funds are establishing robust pricing policies for hard-to-value assets.Rubber stamping the manager's pricing model is no longer acceptable
This paper looks at competition and innovation in retail payments and their relation to payment pricing and payment efficiency. Payment markets are complex and economic theory cannot always guide us. There...
Welcome to the spring 2013 issue of The Journal of Financial Market Infrastructures. It is roughly a year since the Principles for Financial Market Infrastructures were published. Recently, in December...
Insurance Risk and BNY Mellon have conducted a survey to look at how insurance companies are preparing for the new regime and the opportunities and challenges that the changes will bring.
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The past 18 months have been dominated by the race to get single-dealer structured product platforms up and running. Originally designed to improve speed and efficiency, they are now helping to cut costs and take the business into the world of smaller...
Banks need more processing power, and cloud computing offers it. But there are a host of practical issues – from loss of control to regulatory scepticism – that could hold up its adoption. Clive Davidson reports
Jorge Sobehart departs from the idealised concept of rational investors, introducing a simple behavioural model of market reaction to price trends that produces fat-tailed distributions of asset returns in close agreement with historical data
The replication of a portfolio of cashflow instruments with another set of cashflow instruments is frequently used in pricing and hedging. For example, replicating deposits with tradable bonds allows the treasurer to determine an approximate fair value...
Operational risk and effective risk management have taken over from exotic innovation in the structured products market. With the barriers to entry still big enough to put off new entrants to the technology market, the composition of the top 10 technology...
It can take hours for traditional bank systems to run portfolio risk models. That's too slow for some banks, which are now exploring unwieldy – but quick – field-programmable gate arrays. By Clive Davidson
A host of tasks become magically simpler if their more demanding aspects are ignored. Cooking bouillabaisse is easy if it doesn't have to taste nice; bullfighting is less dangerous if the torero remains outside the ring; pricing derivatives is a breeze...
This paper discusses a number of diverse considerations that risk managers need to incorporate into their thought processes and recurring procedures if they are to fulfill their role more effectively in the future
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Press Releases
Bill Introduced in U.S. House to End Trade in Primates as 'Pets'
Born Free USA, the Humane Society of the United States and the Humane Society Legislative Fund commend U.S. Reps. Michael Fitzpatrick, R-Pa., and Earl Blumenauer, D-Ore., for introducing H.R. 4306, the Captive Primate Safety Act, which amends the Lacey Act to prohibit interstate commerce in monkeys, apes and other nonhuman primates for the exotic pet trade.
Born Free USA Leads Urgent Initiative in Connecticut to Protect Children and Animals from Leghold Traps
Born Free USA, a leader in animal welfare and wildlife conservation, is urging Connecticut lawmakers to pass legislation addressing the use of barbaric leghold traps, especially in areas frequented by children and families' animal companions. Leghold traps are freely allowed in Connecticut, with the only requirements being that they are padded when set on land and that they are set 100 feet away from buildings located on some private lands.
Sharon and Kelly Osbourne to Judge Born Free USA's Fourth Annual Fashion Competition for Animal-Friendly Designers
Washington D.C., March 1, 2012 - - Television personality, talk show host, manager, producer, author and philanthropist Sharon Osbourne and her daughter, singer, actress and fashion designer Kelly Osbourne have signed on today to serve as judges for the fourth annual Born Free USA fffashion Competition.
Congressman McKeon and Congresswoman Sanchez Introduce Bipartisan "Big Cats and Public Safety Protection" Act
Washington, D.C. — Today, Congressman Howard "Buck" McKeon (R-CA) and Rep. Loretta Sanchez (D-CA) introduced the "Big Cats and Public Safety Protection Act." Unfortunately, an alarming number of wild cats have been bred and sold as domestic pets in the U.S. This trend threatens public safety and often results in the mistreatment of these animals. Just recently, the tragic events in Zanesville, Ohio, where 49 wild animals were killed after they were let loose on an unlicensed wild animal preserve, showcases the dangerous implications of this trend. Currently, only nine states have laws enforcing "no wild animals permitted," and the remaining states have weak or no laws in existence. This bi-partisan bill will ensure that lions, tigers and other dangerous big cats, do not threaten public safety, diminish global big cat conservation efforts, or end up living in horrible conditions where they can be subject to mistreatment and cruelty.
Major Step in Hawaii on Born Free USA Initiative to Protect Bears from Global Trade
Born Free USA, a leader in animal welfare and wildlife conservation, is urging Hawaii lawmakers to join the majority of U.S. states that fully prohibit the trade in bear gallbladders. On Tuesday, Feb. 21, House Bill 2296 passed the House Judiciary Committee with a unanimous vote (14 yes, 0 no, 1 absent). On Feb. 10, Senate Bill 2232 passed the Senate Judiciary Committee with a unanimous vote (3-0-2).
Both bills now head to the floor of each chamber.
As Trapping Season Comes to a Close, Born Free USA Reports Possible Record High in Non-Targeted Animals Being Crushed
Millions of fur-bearing animals are barbarically killed each year in body-crushing traps set for recreational and commercial purposes, fueling a highly unregulated industry that dates back to the 1600s. Born Free USA, a nationally recognized leader in animal welfare and wildlife conservation, estimates that in addition to those animals, there are hundreds of thousands of non-targeted animals who are the unintended victims of these traps.
Born Free USA Leads Historic Initiative Restricting Private Possession of Dangerous Exotic Animals in West Virginia
West Virginia is one of only eight states left (the others being Alabama, Idaho, Nevada, North Carolina, Ohio, South Carolina and Wisconsin) lacking any restriction or oversight for the private possession of exotic animals. Born Free USA, a recognized leader in animal welfare and wildlife conservation, is working to put an end to the epidemic of exotic animals as "pets" in this country.
Born Free USA Part of Rescue Mission Following Mississippi Roadside Zoo Probe
The Born Free USA Primate Sanctuary has agreed to rescue an abused macaque found living in horrendous conditions at the Collins Zoo in Collins, MS, after an undercover investigation by the Humane Society of the United States revealed serious animal welfare issues and public safety concerns at the facility. Born Free USA is working with HSUS to coordinate the safe transfer of the animal tonight from Collins to the sanctuary in Dilley, Texas.
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Queen Mary Ghost Picture
Amazing shadowed apparition aboard the Queen Mary.
Carnival Ghost Picture
Another best ghost picture taken on-board a cruise ship!
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We're not sure what went wrong, but it isn't his wife!
Shadow Apparition Ghost Picture
A dark figure appears behind her in the kitchen in the best ghost picture!
Tantallon Castle Ghost Picture
This ghost picture surfaced in the UK in 2009!
Canada Ghost Picture
This best ghost picture accidentally appeared on a calendar back in 1989!
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Famed and taken at the Hawthorne birth site.
Craig's Ghost Picture
Her friend died and then appeared in her living room more than once!
Jennifer's Ghost Picture
This ghost picture has been verified as authentic by us!
Moundsville Ghost Picture
Another photograph of the famed shadow man...
St. Augustine Lighthouse Ghost
Apparition of a young girl is photographed standing at the top by men miles away.
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A former church youth volunteer was arrested Thursday afternoon on 38 counts of child sexual abuse related charges.
Timothy Probert, 55, of Bluefield, was taken into custody by Sgt. M.D. Clemons, with the Crimes Against Children Unit of the West Virginia State Police. The alleged crimes stem from incidents that occurred when Probert was a youth volunteer at Westminster Presbyterian Church in Bluefield.
Probert is charged with 22 counts of sexual abuse by a custodian; six counts of first-degree sexual abuse; seven counts of third-degree sexual assault; one count of distribution and display of obscene matter to a minor; one count of use of obscene matter with intent to seduce a minor; and one count of use of a minor to produce obscene matter or to assist in doing sexually explicit conduct.
Clemons said the abuse charges stem from incidents that date back to 1986. The last incident occurred between July 2008 and 2010.
The alleged victims were all male and ranged in age from 12 to 17, she said.
Probert was arraigned Thursday afternoon on the charges before Mercer County Magistrate Jim Dent.
"Nothing that I have now indicates there was any abuse at the church, however some occurred on mission trips and at the individual's home," Clemons said.
Jonathan Rockness, pastor of the church, said in an earlier report that Probert is not on the church staff, nor has he ever been employed by Westminster.
"However, through the years he has volunteered in various capacities for the church, including with youth trips that required chaperones," Rockness said.
"We have been fully cooperative with the authorities and will continue to be, as we are committed to uncovering the truth and seeing justice met," Rockness said previously. "We also hope and pray for healing and wholeness for any potential victims in this situation. We are devastated for them and their families."
Clemons said Probert also served as a WE CAN (Working to Eliminate Child Abuse and Neglect) volunteer during the 1990s. Three of the victims Probert was mentoring through WE CAN.
Breaking News
December 12, 2013
Former Bluefield church youth volunteer arrested on 38 counts of child sexual abuse
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- State Police accident reconstruction team begins investigation into tragic U.S. Route 52 crash
- Investigators say adult victim from fatal Route 52 crash in 'guarded' condition
- Amber alert extended to W.Va.
- Drivers' names released in deadly crash
- UPDATE: Eyewitness describes horrific Route 52 crash that claimed two children
- Crash kills 2 children
- Three-vehicle accident injures multiple victims
- Police say school bus ran over man found on Stoney Ridge Road
- One dead after tractor trailer catches fire, crashes over an embankment
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Book Description
The Spanish Chess Opening, also known as the Ruy Lopez, named a Spanish clergyman who made it popular, is one of the oldest and most heavily analyzed of openings, with many variations having been analyzed up to move 20. Yet, there are still new things being discovered about it. This book covers early attempts by either side to wrest the initiative from the other by means of an early pawn sacrifice.
Among the most popular gambits covered in this thoroughly researched work are the Jaenisch and Marshall Gambits, with substantial original analysis of less common lines such as the Cordel and Dilworth Gambits.
This volume concentrates on the lines which are likely to be of use to the practical player, with the emphasis on variations which are ideal for playing for a win in tournament chess.
Leonid Shamkovich was an experienced Soviet Grandmaster. He was the author of The Modern Chess Sacrifice and many other works. His analysis in Soviet chess magazines was invariably studied diligently by Bobby Fischer. Some of Fischer's wins were attributed to analysis by Shamkovich.
Eric Schiller (born March 20, 1955 in New York City) is an American chess player, trainer, arbiter and one of the most prolific authors of books on chess in the 20th century. In 1974, Schiller was the Illinois Junior Champion. Schiller played for the University of Chicago team several times at the Pan American Intercollegiate Team Chess Championship. Schiller was the Hawaii action and blitz champion for 1988/89. He was an organizer of the Hawaii International chess festivals 1994-98 including 1998 US Open California Champion 1995. Later that year, he appeared as a chess advisor for the music group Phish on some of the stops for their "Chess Tour" where they played an ongoing game of two chess moves per tour stop and some "band vs. audience" partial games as part of their stage performance.
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A Spanish Repertoire for Black
Slay the Spanish
Guide to the Tkachiev Ruy Lopez - Alexei Shirov
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