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Tag Archives: Journal
Stem cell 'first aid' for rat stroke
27 January 2013 Last updated at 20:06 ET Stem cells given in the vital period immediately after a stroke may aid recovery, suggest researchers. Rats injected with stem cells 30 minutes after a stroke had almost normal brain function restored within a fortnight. The Bolivian research team say the method has potential in human trials Continue reading
Poor sleep in old age prevents the brain from storing memories
Jan. 27, 2013 The connection between poor sleep, memory loss and brain deterioration as we grow older has been elusive. But for the first time, scientists at the University of California, Berkeley, have found a link between these hallmark maladies of old age Continue reading
Magnetic levitation tissues could speed toxicity tests
Jan. 24, 2013 In a development that could lead to faster and more effective toxicity tests for airborne chemicals, scientists from Rice University and the Rice spinoff company Nano3D Biosciences have used magnetic levitation to grow some of the most realistic lung tissue ever produced in a laboratory. Continue reading
Science needs a second opinion: Researchers find flaws in study of patients in 'vegetative state'
Jan. 24, 2013 A team of researchers led by Weill Cornell Medical College is calling into question the published statistics, methods and findings of a highly publicized research study that claimed bedside electroencephalography (EEG) identified evidence of awareness in three patients diagnosed to be in a vegetative state. The new reanalysis study led by Weill Cornell neurologists Drs Continue reading
Scientists discover how epigenetic information could be inherited: Mechanism of epigenetic reprogramming revealed
Jan. 24, 2013 New research reveals a potential way for how parents' experiences could be passed to their offspring's genes. The research was published January, 25 in the journal Science Continue reading
Scientists discover how epigenetic information could be inherited: Mechanism of epigenetic reprogramming revealed
Jan. 24, 2013 New research reveals a potential way for how parents' experiences could be passed to their offspring's genes Continue reading
Jet fuel, plastics exposures cause disease in later generations; Reproductive diseases, obesity
Jan. 24, 2013 Washington State University researchers have lengthened their list of environmental toxicants that can negatively affect as many as three generations of an exposed animal's offspring Continue reading
Chance finding reveals new control on blood vessels in developing brain
Jan. 24, 2013 Zhen Huang freely admits he was not interested in blood vessels four years ago when he was studying brain development in a fetal mouse. Instead, he wanted to see how changing a particular gene in brain cells called glia would affect the growth of neurons Continue reading


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The Resource Center has all the info you'll need From content to user feedback, the resource center has the information you need for every level of the entrepreneurial process.
To me, there's no better source for entrepreneurial advice than straight from the entrepreneur. And as an entrepreneur myself, I know there's no one an entrepreneur is more likely to take advice from than a fellow entrepreneur. And herein lies the core value of a new entrepreneurship interview series launched today by the Khan Academy in partnership with the Kauffman Foundation.
The Kauffman Foundation's Thom Ruhe give his POV on Steve Ballmer's address to the entrepreneurship and engineering students at Stanford University. The full video of Steve Ballmer's presentation is available in the video library.
Chasing an entrepreneurial dream can be an all-consuming effort. Particularly in those crucial early days of a startup, founders seem to eat, sleep and breathe their businesses. But this heads-down mode is not without its drawbacks, one of which is neglecting to stay up on current events—particularly the happenings that can impact the entrepreneurs who are inadvertently paying no attention to them.
A few weeks ago I wrote a blog post about President Obama's State of the Union Speech. I observed that entrepreneurial vision was lacking and I wish he had used the occasion to revive bipartisan support for an entrepreneurial agenda that could have given both parties things to support.
The White House's Startup America initiative shines a welcome light on the innovative, next-generation Midwest manufactures that are redefining manufacturing.
For many, the biggest problem with getting a good business idea off the ground is the cost. From administrative and legal costs, to product development and marketing, office space and employees, starting a business can be incredibly expensive. However, with the right set of...
People from 30+ countries, speaking multiple languages, sharing diverse cultures, coming together around one theme – entrepreneurship. So it was recently when I had the opportunity to address the 18th Annual Congress of the European Business & Innovation Centre Network (EBN), in Fez,...
The Series Seed Financing Documents are a standardized set of documents that can be quickly and easily deployed for a seed investment.
While exploring Seattle's startup scene for the sake of our most recent ID8 Nation, I quickly discovered that the Emerald City's entrepreneurial ecosystem, which recently has received comparisons to Silicon Valley, is all its own.
SDForum Investor Forum: Powered by DLA Piper and SDForum provides entrepreneurs exposure for up to 15 selected technology companies to make targeted connections in Silicon Valley. Learn how you can participate in the SDForum Investor Forum.
Want to get connected? Sign up to receive regular news, polls and updates from The Kauffman Foundation.

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Retailers wait to see if economic concerns keep shoppers from Black Friday sales
Not everyone is a fan of the extended hours. While the holiday openings, with their doorbusters and giveaways, create buzz, the downside is that adding hours on Thanksgiving can damage employee morale and performance in the long run, said Paul Swinand, a retail analyst at Morningstar Inc. in Chicago.
More than 130 petitions asking large retailers to forgo holiday hours have been introduced this year, according to Change.org, a website that allows activists to post petitions. That includes one from a Target worker calling for the Minneapolis-based discounter to revert to a 5 a.m. Black Friday opening that has garnered more than 350,000 signatures this year, according to the organization.
Wal-Mart workers demanding better pay and benefits have vowed to stage more than 1,000 protests online and outside U.S. stores this week. To gain leverage, protest leaders will have to turn out significant numbers of strikers and persuade bargain- hunters to go elsewhere. Similar protests in recent weeks have had little perceptible impact.
Some merchants, including J.C. Penney and Staples, say they'll remain closed on Thanksgiving because they don't want to infringe on their workers' time with family.
Even without opening early, retailers will benefit from the maximum number of days possible - 32 -between Thanksgiving and Christmas this year, said Roseanne McCauley, vice president of the Americas for Experian FootFall, which tracks traffic and other data for retailers.
"People have two more paychecks coming in before the end of the month," she said.
Adding a sales day from Thanksgiving "is going to absolutely increase volume" for retailers, enabling them to stick to their planned schedule of markdowns, McCauley said. "At the end of the day, the hours are driven by the consumers."
- With assistance from Matt Townsend, Sapna Maheshwari, Renee Dudley and Elizabeth Dexheimer in New York, Cotten Timberlake in Washington and Ari Altstedter in Toronto.


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THE GREAT SCAMPER!Save the Date for Camper Scamper 2013 to raise funds for the kids -- Saturday, October 5... Read more >>TWEEN CREEKS BOYS AT SPRUCE RUNFeeding the fawns at the Crissman Farm, July 27, 2013... See photos >> |
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for your next event... Roger Jackson Interview on Comcast Newsmakers A Movie's Worth a Thousand Words!
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Anvil Unisex Heavyweight Ringer Tee (More Styles...)
Anvil heavyweight 100% pre-shrunk cotton t-shirt with contrasting collar and sleeves. Has a regular fit and retro look making it great for teams. Sizes: SM-2XL
Mens & Unisex Jump to: Tees Long Sleeve Tanks Sweatshirts Juniors / Women's Fitted Kids & Babies Accessories Description: Appenzell Ausserrhoden ; in English sometimes Appenzell Outer Rhodes) is a canton of Switzerland. The seat of the government and parliament is Herisau, judicial authorities are in Trogen. Appenzell Ausserrhoden is located in the north east of Switzerland, bordering the cantons of St. Gallen and Appenzell Innerrhoden. Search: GRIFFINS, GRYPHONS, HERALDRY, Appenzell Ausserrhoden, switzerland
More designs in THE GRIFFIN PASSANT STREETWORKS/COAT OF ARMS


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Apparently pete (the guy behind BB) made a script that auto-scaled the overclock of the kernel. So you can either leave the script intact or edit out the CPU speed governing portions of his script.
The script is called pete.
Read pages 212-214 of the BB 1.0 post and you'll see the whole argument, in detail.


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Bani M. Azari, daughter of Bijan and Cynthia Azari of Bremerton, earned a bachelor's degree in biology from the Massachusetts Institute of Technology in Cambridge this spring.
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Endura Cycling Apparel Endura Men's Dexter II Glove
Made from windproof, breathable, soft shell fabric--not to mention bodymapped stretch paneling for extra movement and dexterity--the Men's Endura Windproof Glove is just what your winter cycling hands need. Plus, soft, tri-gel padding zones and silicon print palm and fingertips enhance your experience with extra comfort and added grip.
- Material: Windproof, breathable soft shell fabric
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- Soft, tri-gel padding zones
- Silicon print palm and fingertips for grip
- Durable overlay on thumb crotch
- 3D thumb cut with lifeline seam for comfort fit
- Reflective prints
- Soft knuckle padding
- Embossed neoprene cuff with Velcro® adjustor
- Full finger terry sweat wipe
Purchase the Endura Cycling Apparel Endura Dexter II Glove for Men from Altrec.com. All order totals over $45 qualify for free ground shipping.
- Men's Running Gloves
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More on TODAY.com
Health on
- How Tommy John Surgery Has Evolved Since Frank Jobe
- The New Old Age Blog: Geriatricians Question Five Common Treatments
- Well: Think Like a Doctor: Sweating It Solved!
- Is There a Doctor in the House? Yes, 17. And 3 in the Senate.
- Think Like a Doctor: Sweating It Out
- Well: Building a Meal Around Roasted Vegetables
Searchers scour South China Sea for signs of missing jet
Crews used planes, boats and helicopters to search for any sign of a Malaysia Airlines plane carrying 239 people, including three Americans, that lost contact with air traffic control en route to Beijing.


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All four units at Georgia Power's Plant Bowen coal plant remained shut down Friday as the utility began investigating what caused an explosion the day before.
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Our operating values
The Triumph of Humanity
We aspire to engage others in this new era of social responsibility that yields honorable business. It is our pledge to put our planet as well as our stakeholders, in both commerce and community, in proportion to profitability. Through trust and credibility, we will build the foundation to further social and environmental justice – for humanity's sake.
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The village of Casan is 4,66 kilometers far from the same town of Ponte nelle Alpi to whom it belongs.
To the municipality of Ponte nelle Alpi also belong the localities of Arsie' (5,45 km), Cadola (2,02 km), Col - Roncan (4,18 km), Col di Cugnan (2,35 km), Cornolade (7,46 km), Cornolade Alte (6,72 km), Cornolade Basse (7,59 km), Cugnan (3,07 km), La Secca (6,98 km), Lizzona (6,16 km), Losego (4,46 km), Mares (4,79 km), Mares Pises (2,68 km), Maset (5,28 km), Mazzucchi (6,70 km), Paiane (3,41 km), Paiane - Casan (4,09 km), Piaia (2,42 km), Pian di Vedoia (2,21 km), Pises (4,36 km), Polpet (0,41 km), Ponte delle Schiette (5,67 km), Ponte Nelle Alpi - Polpet (-- km), Pus (7,30 km), Quantin (6,73 km), Reveane (5,81 km), Roncan (5,16 km), Soccher (3,34 km), Vich (4,66 km)
The number in parentheses following each village name indicate the distance between the same village and the municipality of Ponte nelle Alpi.
Please notice that in what follows no statistic nor population data are available at the moment: the same are available for the Italian places having al least the status of municipalities ad for most of the villages too.
The distribution of the most commun family names is equally unavailable.
Please find in what follows:There are no parishes in Casan.
Weather and weather forecast for Ponte nelle Alpi, to whom Casan belongs.
You can arrange the results by number of stars, by popularity, by distance or even by the guest review score choosing among young couples, mature couples, families with young children, families with older children, people withfriends, or solo travellers.
Most recent free ads in Casan, municipality of Ponte nelle Alpi, province of Belluno, Veneto region, updated at 04:46:32, 08 March 2014.
Up to now there is no free ad placed in Casan |
Most recent free ads in the province of Belluno | |
sistemi audio video domotica | 2013-11-26 |
bed and breakfas camere da beppe | 2013-09-28 |
Coccolarsi nel mezzo delle Dolomiti Bellunesi | 2013-07-02 |
Most recent free ads in the region Veneto | |
Location Villa Valcorba Duse Masin | 2014-02-04 |
sistemi audio video domotica | 2013-11-26 |
Animazione turistica PRIMAVERA/ESTATE 2014 | 2013-11-21 |
Place your free ad on Casan: no registration needed.. Place your free ad.
Il Lago Di Val Gallina Dalla Vetta Del Dolada |
Fonte A Soccher |
Alpes: Chuesa De S. Martino |
Photo |
Chiesa Di Santa Maria Del Rosário. Ponte Nelle Alpi Belluno |
Chiesa Della B.v. Di Castelmonte - Ai Mazzucchi |
Chiesa Di S.pietro Apostolo - Reveane |
Soccher |
Chiesa Di S.martino Vescovo - Casan |
Capitello Di S.antonio |
Look at the interactive map of Casan and get the road maps, the satellite maps and the mixed ones too.
Interactive maps of Casan also allow an immediate view of:
Just click on any of the categories above to see them located on the map.
The free text search box input field at the bottom of the map allows you to search any kind of business activities within the map itself.
A selection of videos about Casan, Ponte nelle Alpi, Belluno, Veneto


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Previews from the upcoming Captian Marvel series!
Captain Marvel #4 cover by Ed McGuinness
Available in September!Written by Kelly Sue DeConnick, interior art by Dexter Soy! The first issue (covers by Ed McGuinness & Adi Granov below) arrives July 18, 2012 in comic shops and on the Marvel app!
Which of these covers is your favorite?
Pulp Fiction Timelines
Not comic book related but Samuel L Jackson is in there somewhere, and that's good enough for me!
ONE OF THE ONLY interviews with comic Creator Sean Murphy (Punk Rock Jesus, American Vampire)
Click on the Image for the interview we did with Mr. Murphy at C2E2 2012!
The Before Watchmen: Comedian cover is the best one of the bunch. Not really digging Risso one too much.
Variant Cover by JG Jones
A first look at The Walking Dead's 'The Governor'
Where's the eye patch???
If you're reading DB Cooper from ONI Press, here's a little tumbl from artist himself!
DB Cooper work-in-progress detail


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March 19, 2012
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OPEN SPOTS in our SPRING 2014 INTRO to BRUSH LETTERING WORKSHOPS!
We still have THREE open slots in next weekend's workshop, in case you want to start sign painting THIS MONTH!
Sat & Sun, 15, 16 February 2014 10-5pm each day
Sat & Sun, 8, 9 March 2014 10-5pm each day FULL
Sat & Sun, 22, 23 March 2014 10-5pm each day FULL
The class will include a total of 12 hours of teaching, over the course of 2 days—two 3 hour sections each day with lunch breaks in between. At class's end, you will own a lettering quill, a small can of 1Shot Poster Paint and a small sign of your own design (or of ours, if you wish), and some greater portion of the wherewithal and gumption to launch a fulfilling career in sign painting!
The first day: After an introduction to our tools and raw materials, you will practice the basic strokes of brush lettering an alphabet, using poster paint on paper. We'll focus on the sign painters' favorite, "casual", or "speed" letters, before lunch, and on single stroke sans-serif letters, after, with perhaps a brief foray into twisting serifs (if we're goaded into it). Toward the end, I'll explain how we prep signboards for lettering.
The second day: First, you'll lay out designs, and make patterns for your sign, to be painted in enamel on a 10"x24" board we will have already prepared for you. For the purposes of this class, you'll design for a single color of lettering. I encourage you, now, with whatever lead time you have, to start thinking about what you'd like your sign to say—bearing in mind the value of concise messaging, the size of the board, and the limits of both the assignment and your skill! If you'd rather not design a sign, quite alright: we'll have some design sketches here ready for you to use or adapt. Then, you'll paint your signs! You can take them with you at the end, or leave them here to dry.
There will be no more than 10 people in this class at a time. A space at the easel for this class runs a mere $300. Please email, nbsigns at gmail, and mention a particular date, if you wish to reserve a spot for yourself, and we'll hold it for you for five days, pending full payment. You can call with Visa/Mastercard, mail (or hand deliver) a check to our street address (281 9th St., SF, CA 94013-3825), or Paypal tuition to the above email address. Enrollment ends one week prior to each class.


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text: . Who I am, who I used to be you still feel. The deep wound in my soul you somehow heal. Each time on me your affection you lay, the darkness deep in me is cast away. And it's you who light my path now and then, convincing me I'm worth your love once again. .


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Copyright © 2012 Elsevier Inc. All rights reserved.
Molecular Cell, Volume 47, Issue 1, 99-110, 17 May 2012
Add/View Comments (0)STT3B-Dependent Posttranslational N-Glycosylation as a Surveillance System for Secretory Protein
Takashi Sato1, 2, 7, 8, , , Yasuhiro Sako1, 8, Misato Sho1, 8, Mamiko Momohara1, Mary Ann Suico1, Tsuyoshi Shuto1, Hideki Nishitoh3, Tsukasa Okiyoneda4, Koichi Kokame5, Masayuki Kaneko6, Manabu Taura1, Masanori Miyata1, Keisuke Chosa1, Tomoaki Koga1, Saori Morino-Koga1, Ikuo Wada2 and Hirofumi Kai1, ,
1 Department of Molecular Medicine, Global COE Cell Fate Regulation Research and Education Unit, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto 862-0973, Japan
2 Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan
3 Division of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
4 Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada
5 Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan
6 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba 288-0025, Japan
Corresponding author
7 Present Address: Department of Cell Fate Control, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan
8 These authors contributed equally to this work
Graphical Abstract
► A cryptic N-glycosylation site of TTR is posttranslationally glycosylated by STT3B ► N-glycosylation increases the solubility of aggregation-prone TTR ► N-glycosylation of TTR provides an alternative pathway for degradation ► N-glycosylation of TTR depends on the severity of unfolding state
- Nascent secretory proteins are extensively scrutinized at the endoplasmic reticulum (ER). Various signatures of client proteins, including exposure of hydrophobic patches or unpaired sulfhydryls, are coordinately utilized to reduce nonnative proteins in the ER. We report here the cryptic N-glycosylation site as a recognition signal for unfolding of a natively nonglycosylated protein, transthyretin (TTR), involved in familial amyloidosis. Folding and ER-associated degradation (ERAD) perturbation analyses revealed that prolonged TTR unfolding induces externalization of cryptic N-glycosylation site and triggers STT3B-dependent posttranslational N-glycosylation. Inhibition of posttranslational N-glycosylation increases detergent-insoluble TTR aggregates and decreases cell proliferation of mutant TTR-expressing cells. Moreover, this modification provides an alternative pathway for degradation, which is EDEM3-mediated N-glycan-dependent ERAD, distinct from the major pathway of Herp-mediated N-glycan-independent ERAD. Hence we postulate that STT3B-dependent posttranslational N-glycosylation is part of a triage-salvage system recognizing cryptic N-glycosylation sites of secretory proteins to preserve protein homeostasis.


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Price: £250
The Nikon Coolpix S100's performance doesn't quite live up to its looks, and, while this compact camera is packed with features, its price is too high for our liking. Read full review
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Hi everyone, Say Joel i was wondering if you could answer a question for me? Do you happen to know how to access the "Warm2" setting after you have used it for the first time? For the life of me i can't seem to locate that setting after i had first set up the tv:confused:
post #61 of 103
1/14/13 at 2:11am


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Click on the image to zoomFeatures
- Brand
- LSA International
- Dimensions
- H30cm
- Eligible for International Delivery
- Hand wash
- Microwave Safe
- Oven Safe
Product information
Add a touch of sophistication to your tableware and present snacks and appetisers using this elegant trio dish by LSA. Hand-crafted from clear, sparkling glass with a simple and chic design, it makes a functional and decorative piece.
Editor's Notes
LSA International's unique style, original designs and enduring quality have secured their position as one of Europe's foremost brands of contemporary handmade glass and porcelain. The elegant yet practical Serve collection is designed with a classic, timeless feel to it and almost every piece has a dual function.
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Old PS/2 Keyboard won't Repeat (sort of)
Last response: in Computer Peripherals
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XV - AaaHH! Real Monsters
Artist: XV
Featuring: ScHoolboy Q
Producer: The Awesome Sound
Album: Popular Culture
Avg Rating: 3.7 ( 7 total votes )
I never thought I'd see the day when ScHoolboy Q, the author of such children's favorites as Nightmare on Figg St. and Druggy Wit Hoes was on a track named after a mid-'90s Nickelodeon show, but I guess that just goes to show the power of XV to bring worlds together. Produced by Vizzy's constant production partner The Awesome Sound, new leak AaaHH! Real Monsters rides along on a hazy and slowly smoking beat that could have just as easily come out of Houston as Wichita. On the mic XV follows suit by showing his more aggressive side, although even at his hardest this lyrical monster can't help but throw down some video game references: "Shock the world like Blanca / whippin through the city in the Phantom of the Opera." More his part, ScHoolboy meets Vizzy in the middle, delivering one of the more relaxed offerings I've heard from his yet. Does more unexpected hip-hop await us on XV's Popular Culture mixtape? We won't have to wait long to find out, the mixtape is set to drop tomorrow, Friday, June 15.
Listen to More: XV , ScHoolboy Q Written by Nathan S.
Square Bound Music/Warner Bros.
First DJ Booth Appearance:
"U Got It ft. Lil' Wayne" (2008)
Member Reviews and Ratings
- 25 Most Popular Hip-Hop & R&B Songs of February 2014
- Pharrell - G I R L
- Rick Ross - Mastermind
- ScHoolboy Q - Oxymoron
- A 15 Song Tour Through Pharrell's Career
- SchoolBoy Q ft. 2 Chainz - What They Want
- Future ft. Pharrell, Pusha T & Casino - Move That Dope
- Nyzzy Nyce - Nothing Nyce
- Devin Miles - Where the DJs At?
- The Best Hip Hop Songs & Albums of 2013!


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MuseBoat Radio will be introducing Bri Payne on Sunday October 13th in TJ´s Muse Bridge LISTEN & CHAT show at 10pm-London, 11pm-Berlin, 5pm-New York, 2pm-Las Vegas, 9am- Sydney, 7am-Tokyo, 7pm Rio de Janeiro here: http://museboat.wix.com/multimedia
Recording for "Save Our Souls" began in the summer of 2013. By the end of summer, we returned to the studio to record the vocals. During the recording session we unexpectedly captured some real nice vocal improvisation.
Although the vocal parts were unrehearsed, we were initially committed to leaving them "as is". Much to our surprise, our original song idea evolved during a single recording session.
We had a great time in the studio with "Save Our Souls" and we are all quite happy with the end result.
I would like to thank Co-Producer, Matt Logan, for a great job. We would also like to credit Gina, of Ginici Design, for the CD cover art work.
The final master of "Save Our Souls" was completed on September 28th and is scheduled for release on October 7th 2013.
We recorded the vocals to our new song "Save Our Souls" on Labor Day. We are now working on the final mix.
On July 13, 2013 we posted a new song called "My Love". Please check it out here on Reverb Nation or at our web site www.bripayne.com
On April 22, 2013 we posted a new song written by Sal Dibenardo called "Why Am I". Please check it out here on Reverb Nation or at our web site www.bripayne.com
We will be adding new songs as they are recorded so please check our home page frequently for news and udates. See our "music page" for available songs. Please feel free to leave a message in our guestbook or join our mailing list at the bottom of the "Home" page.


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Our beloved grandfather, Poppy Sol, started this business in an open-air market. Three generations later, we're still bringing smiles to our customers' faces.
Lemoncello Almonds
Roasted almonds first coated in a rich, white chocolate and then topped with a layer of delectable lemon cream. These gorgeous yellow pastel treats will surely be adored by you and your guests. Lemoncello almonds (aka Limoncello almonds) are perfectly sweet party or wedding candy favors. Enjoy them as a snack or after-meal treat to satisfy a sweet tooth. Their sweetness is complemented by satisfying protein and the antioxidant-rich goodness of delicious roasted almonds. You won't want to pass up these Lemoncello almonds!
Customer Reviews
Leave online feedback and share your thoughts with other customers!
jane, tunkhannock, Pennsylvania October 11, 2013"Thank you for such fast delivery.. love , love love the lemon coated almonds! I couldn't stop eating them when they arrived. I will be back soon ~"
William, Centerport, New York February 4, 2014"Great stuff, glad I found you. My neighbor is going to be really happy.
Keep up the good work. We will be using your survives again soon. Thanks for the chips
Your friends at Perksport,
Bill & Laura"
Nutrition Facts
Serving Size 40g (~1.4 oz.)
(Approx. 11.4 Servings/Pound)
Amount Per Serving | |
Calories | 220 |
Calories From Fat | 130 |
Total Fat | 15g | 23% |
Saturated Fat | 6g | 30% |
Cholesterol | 5mg | 1% |
Sodium | 15mg | 0% |
Total Carbohydrate | 20g | 7% |
Dietary Fiber | 1g | 4% |
Sugars | 18g | |
Protein | 4g |
Vitamin A | 0% | Calcium | 8% |
Vitamin C | 0% | Iron | 4% |
White Chocolate (Sugar, Cocoa Butter, Whole Milk Powder, Soy Lecithin - an emulsifier, Natural Vanilla Flavor), Almonds, Confectioners Coating (Sugar, Palm Kernel Oil, Nonfat Milk Powder, Anhydrous Milkfat, Soy Lecithin - an emulsifier), Cream {Milk}, Tapicoa Dextrin, Natural Lemon Flavor, Color Added (FD&C Yellow 5 Lake), Confectioners Glaze. ... CONTAINS ALMONDS, MILK and SOY
Packaged in the same facility as peanuts, tree nuts, wheat, soy, and milk products.
Store in a cool, dry place for up to 6 months. We do not recommend refrigeration or freezing.


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12 Planned Horror Movie Remakes That Haven't Happened (Yet) Today we take a look at twelve horror films that were well on their way to being remade... but somehow ended up getting spared. John Squires - 09/23/2013 - 4:00pm - 0 comments
Eight of the Scariest Movies Ever Marketed to Children The films on this list undoubtedly resulted in a a lot of sleepless nights for young fans of fright flicks! Tyler Doupe - 08/27/2013 - 3:00pm - 0 comments
Seven of the Worst '80s Horror Movie Hairstyles Crimps, mullets and mohawks... these horror hairstyles seemed like a good idea at the time, but they just don't quite hold the same sense of wonder as they did back in the day. Tyler Doupe - 08/19/2013 - 4:00pm - 0 comments
50 Greatest Mondo Horror Posters - Part 1 The Alamo Drafthouse's fine arts arm, Mondo Gallery, has quickly become the pinnacle of pop art.Alyse Wax - 05/28/2013 - 8:00pm - 2 comments
Drop Goblin: 'The Gate' – EP Review Metalstep monster Drop Goblin just released a musical dedication to the classic '80s demon-monster flick. Find out more and listen to a bonus track! Gregory Burkart - 05/06/2013 - 1:00pm - 0 comments
FEARFUL FIRST FIVE - The Gate Two children decide to bury their dead dog in a hole left from the removal of an old tree. Bad things begin to happen, as they soon discover the hole is actually a gate to hell. Rob Galluzzo - 12/03/2012 - 1:36pm - 0 comments
Watch 'The Devil's Rejects' Right Now Here On FEARNET Whether you're a fan of Rob Zombie or not, it's hard to deny his distinct style as a filmmaker and the diversity of his filmography thus far. Rob Galluzzo - 11/12/2012 - 7:00pm - 0 comments
Surviving the Frankenstorm: What to Watch Now that you've hurricane-proofed your home and have everything you need to make french toast there's only one thing to do while you wait for the Frankenstorm to finish punishing the East Coast: watch a movie. Sara Castillo - 10/29/2012 - 5:30pm - 0 comments
The Gate trailer Two children decide to bury their dead dog in a hole left from the removal of an old tree. Bad things begin to happen, as they soon discover the hole is actually a gate to hell. Rob Galluzzo - 10/18/2012 - 1:01pm - 0 comments
Our Favorite Horror Kid Heroes The upcoming release of ParaNorman features one quirky kid with a very special talent.Giaco Furino - 08/03/2012 - 3:00pm - 1 comment


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Barney Frank cries foul in government's lawsuit against JPMorgan
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WASHINGTON (Reuters) - Democratic Congressman Barney Frank defended the nation's largest bank on Monday, saying in a statement that the government was wrong to go after JPMorgan Chase & Co for the alleged misdeeds of Bear Stearns.
Frank, the co-author of the 2010 Dodd-Frank financial reform law, said federal and state officials should reconsider holding financial firms liable for the wrongdoing of institutions they absorbed at the government's urging.
The unusual statement comes after New York Attorney General Eric Schneiderman sued JPMorgan, the nation's largest bank by assets on October 1 over mortgage-backed securities packaged and sold by Bear Stearns.
A JPMorgan spokeswoman declined to comment.
Since that suit was filed JPMorgan Chief Executive Jamie Dimon lashed out at the decision.
At a Washington event on October 10, Dimon said his bank and its shareholders were still paying the price for doing the Federal Reserve "a favor" by buying Bear Stearns in early 2008, when its instability was threatening the larger financial system.
Dimon said the suit could make financial firms think twice in the future about rescuing their failing rivals.
Frank, who served as chairman of the House Financial Services Committee during the Bear acquisition, said in his statement: "The decision now to prosecute J.P. Morgan Chase because of activities undertaken by Bear Stearns before the takeover unfortunately fits the description of allowing no good deed to go unpunished."
Frank backed up Dimon's assertion that it was the government that pushed Bear Stearns on JPMorgan.
Federal officials "believed that the failure of Bear Stearns would have terribly negative consequences for the economy," Frank said.
The officials urged JPMorgan "to do a good deed by taking over an institution which, I believe, the bank would never have sought to acquire absent that urging," he said.
A spokesman for the New York Attorney General's office did not immediately respond to a request for comment.
Frank also drew a line between what he said were fair legal actions and unfair ones, while noting he was not advocating for immunity for banks.
For example, he said Bank of America should probably be shielded from government legal action related to Merrill Lynch, which Bank of America took over in part because of federal officials' urging.
However, Frank said he was aware of no federal urging that led former Bank of America CEO Ken Lewis to take over Countrywide.
(Reporting By Aruna Viswanatha. Editing by Andre Grenon)
True statement. But what was the reason the Fed did this?
Why did these big commercial banks join in this conspiracy with the Fed and the Treasury?
I know why. Let's here what others think.
- Malaysian plane presumed crashed; questions over false IDs |
- CORRECTED-UPDATE 4-Malaysia Airlines plane crashes in South China Sea with 239 people aboard - report
- China draws 'red line' on North Korea, says won't allow war on peninsula
- Warning shots fired to turn monitors back from Crimea |
- Malaysian plane crashed off Vietnam coast: state media
Volvo's U.S. headache
Volvo sales are recovering but falling U.S. market share has analysts worried. But CEO Hakan Samuelsson sees opportunity in 2014. Video | Slideshow


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Loading... The Print (Ansel Adams Photography, Book 3) (edition 1995)by Ansel Adams, Robert Baker (Contributor)
Work detailsThe Print (Ansel Adams Photography, Book 3) by Ansel Adams
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References to this work on external resources. Wikipedia in English (3)Amazon.com Product Description (ISBN 0821221876, Paperback)The technical information is clear and concise, starting with deisinging and euqipping a darkroom and continues through making the first print, ending with all sorts of professional tips and tricks for achieving that special image.(retrieved from Amazon Mon, 30 Sep 2013 13:32:26 -0400) No library descriptions found. |
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Converts your 6-pin connector to a dual G/A plug for additional connection flexibility. Adapter measures 54.61cm (21.5").
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Pachmayr RP200 Sure Grip Rifle Recoil Pad 1/2" Black with White Line Medium with Stippled Face
Product #: 227953
Pachmayr #:
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Product Information
This economical recoil pad is great for rimfire and other small calibers. Features a stippled face for a sure grip on the shoulder and a field style contour.
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Dried apricot sweets
(You can click on ingredients to see more related recipes)
200 g | Dried apricots, finely chopped |
50 g | White chocolate |
½ can | Sweetened condensed milk |
¼ cup | Icing sugar |
¾ cup | Desiccated coconut, plus extra for rolling |
1 | Orange, grated rind only |
- Mix all ingredients together,except 1/4 cup of coconut. Cover and refrigerate overnight.
- Next day, form the mixture into small balls, each about the size of a walnut, and roll the balls in dessicated coconut.
- Keep refrigerated until needed. These sweets will last well for up to three weeks if they are stored in an airtight container in the refrigerator.


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No Refusal DWI Checkpoints
View Single Post
12-28-2012, 15:17
Officer X
Senior Member
Join Date: Dec 2008
Location: The Garden State
Posts: 1,303
For the reading impaired:
I have let people go who have cooprated where upon further testing, it was my belief that you were not, or I could not prove DWI. Those drivers were thanked for their cooperation and time, issued the appropriate summons or warning and sent on their way.
If someone wanted to "play games" and not cooperate or be a b-ll buster, If I had enough PC on my observations, I would articulate those in my report to testify in court. Just because someone doesn't want to cooperate doesn't mean you get a free pass.
To be clear :
1. Endowed with the power of speech.
2. Composed of distinct, meaningful syllables or words, as human speech.
3. Expressing oneself easily in clear and effective language: an articulate speaker.
4. Characterized by the use of clear, expressive language: an articulate essay.
5. Anatomy Consisting of sections united by joints; jointed.
1. to make, build, or construct
2. to devise, invent, or concoct (a story, lie, etc.)
3. to fake or forge
[from Latin fabricāre to build, make, from fabrica workshop; see fabric]
It seems that you are using your own prejudice to twist my words to fit your definition.
Officer X
View Public Profile
Find More Posts by Officer X


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Rightz - 9:54 pm on May 16, 2006 (gmt 0)
Is it something to do with my host? My ftp software (although never seen this before)? My domain registrant? None of them are chinese!
I should add this happens on each page I've tried - no matter the content. I know the html is correct.


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Read More: http://sportsillustrated.cnn.com/danpatrick/blog/94521/index.html#ixzz0dSJU875q
Darius Rucker and band rock the DP Show studio
Tagged with music sports radio dan patrick darius rucker
Possibly related…
The Dan Patrick Radio Show - Hour 1 (08-24-2012)
The official home of the Dan Patrick Show. Interact with Dan Patrick and the Danettes as they debate sports on a daily television and radio show. Listen to Dan interview the biggest athletes and celebrities in the world and cover the day's biggest sports stories.
Elite Sport, Sports Coaching, Sports Psychology | Sports Coach Radio
Dan Patrick - Hour 3 - Chi McBride talks about Prince's house
Hour 3 — Jeff Fisher previews conference title games; Chi McBride talks about Prince's house Read More: http://sportsillustrated.cnn.com/danpatrick/#ixzz0dBxFKURO
Tagged with radio prince sports dan patrick chi mcbride


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SFBC Biker BulletinMarch 16, 2010March 16, 2010"Membership gives us ambassadors, volunteers, revenue -- basically, everything we need to propel our cause." Table of Contents
One Tweak at a Time Market Street Changes Abound The SFMTA has been busy tweaking the ongoing experiment with requiring private cars to turn right off of Market Street at 10th and 6th streets, thanks to your many thoughtful comments about the odd and confusing path of travel for people on bikes at 10th Street. The City's design team, along with SF Bicycle Coalition staff, were out at the 10th street intersection assessing the signage and lane configurations earlier this week. The City has developed a revised design and has made adjustments that should help direct all modes of traffic better. Have you pedaled through this week? Is this new design working for you? Send your comments on whether it's working or not to the Better Market Street project team here or leave a comment on the Better Market Street facebook page. Parklet Comes to Life Hop on your bike and ride over to Cafe Mojo on Divisadero between Grove and Hayes, just off the 'Wiggle' route to see something new and amazing. The City's Pavement to Parks program has installed the city's first Parklet, a platform with seating, greenery and -- yes -- bike parking, transforming the street's spaces normally used for car parking. This trial Parklet is the first of many more to come throughout the city. Huge thanks to the many volunteers with SF Bicycle Coalition's Great Streets Project who have been out in rain and shine over the last couple of weeks building the installation, and counting and interviewing people about this new project. You've made history! And a huge bravo to the Pavement to Parks program and Mayor Newsom for testing out this great idea for improving public space in our cozy city. You'll remember that the Bicycle Coalition helped business owners and City leaders experience this innovative idea back in September on PARK(ing) Day, the one-day event that re-purposes street parking spots into extra room for cafe tables and chairs, bike parking, and mini-gardens, giving pedestrians and bicyclists more room. Sunday Streets Fans Flock to the EmbarcaderoFirst Sunday Streets of the Year a Huge Success! Tens of thousands of adults and kids flooded the car-free Embarcadero on this year's first Sunday Streets event! And next month, on Sunday April 11th, you will be able to take part in the second Sunday Streets from Golden Gate Park to the Great Highway. The Sunday Streets route will be hopping with activity from bicycling to dancing and rollerskating, yoga to hula-hooping. Read press coverage of the event at the SF Chronicle.
Help Make Bike to Work Day 2010 GreatBe a Bike to Work Day Volunteer: Last year, over 300 amazing volunteers helped make Bike to Work Day a roaring success, and we're hoping to be joined by just as many volunteers this year. Volunteer for Bike to Work Day on your commute route, where you can meet fellow riders and dispense treats and cycling advice at our neighborhood Energizer Stations. Bike to Work Day on Thursday, May 13th, is one of the grandest and most fun bike events of the year. But, we need YOU to make it happen. Sign up today at sfbike.org/vol_sign_up_btwd.
Celebrating the Leaders of ChangeMark your calendars for the 18th annual Golden Wheel Awards -- Tuesday, April 27th -- to celebrate the leaders of change who are working to create great streets and a world-class bicycling city. We guarantee a grand evening in the beautiful Green Room in the War Memorial Building where you'll enjoy great wine and beer and tasty hors d'oeuvres while mingling with fellow members and local VIPs. The Golden Wheel Awards is an important fundraiser for our organization. Buy your tickets today and support our non-profit work creating a more livable and bikeable San Francisco. If you are unable to attend, please consider making a special contribution today. Pedal Power: Volunteer with the SF Bicycle CoalitionVolunteer for car-free outreach at Sunday Streets: Join the SF Bicycle Coalition under our orange tent at Sunday Streets and talk to people about our work! Your volunteering gets you a free Sunday Streets t-shirt, lunch, and the great feeling that you helped make Sunday Streets possible. If you are a trained SF Bicycle Coalition outreach volunteer and would like be an outreach hero(ine) email firstname.lastname@example.com.
Holla for Haulers: The SF Bicycle Coalition bikes over 800 pounds of Tube Times newsletters to the post office, and we need you to keep that going! Email Tessa today if you're interested in being one of our amazing strong-legged haulers, helping us bike our upcoming Tube Times mail delivery. Picnics, Frisbees and Bikes Join the San Francisco Bicycle Coalition -- and all park fans -- on Saturday, April 3rd (12noon-2pm) for a casual picnic in Golden Gate Park's 14th Avenue East Picnic Area (just west of the Rose Garden) to kick off another six months of car-free Healthy Saturdays. The SF Bicycle Coalition spent years working with a broad coalition of groups to win this car-free space (learn more about our successful work on Healthy Saturdays here). We'll be celebrating this family-friendly victory in the park with a Freedom from Training Wheels program for the kids, and for the adults good ol' lounging and chatting. Bring a frisbee, a blanket, and some snacks or drinks to share at the potluck picnic. We hope to see you there! Rain cancels. SF Bicycle Coalition's Kate McCarthy Receives National Award The Alliance for Biking and Walking (a national coalition of over 160 grassroots bicycle and pedestrian advocacy organizations) has honored our very own Kate McCarthy (Membership and Volunteer Director) with the 2010 Susie Stephens Joyful Enthusiasm Award for her tireless enthusiasm "to harness the power of individuals to better bicycling." Under Kate's leadership, the SF Bicycle Coalition has grown to a powerful 11,000 members who are actively committed to making San Francisco streets more dignified for biking and its neighborhoods healthier places to live. Last year, our member-volunteers donated more than 16,000 hours to keep our office running smoothly and kept bicycle improvements moving forward--thanks, members! Kate also shares her knowledge with bicycle advocacy organizations across North America, so other cities can benefit from our effective strategies and winning campaigns for bikes. Congratulations, Kate. Read more on SF Streetsblog. Calling All CreativesAre you a wordsmith on wheels? The SF Bicycle Coalition has blogging opportunities and writing assignments and is in need of talented writers. Whether you've got great ideas for stories, or would be willing to take assignments, your talents will be put to good use helping spread the good word about bicycling. Let us know your skills and areas of interest, and include writing samples to firstname.lastname@example.com. Take Action: Speak Up for Bike Funding On the eve of last week's National Bike Summit in Washington DC, Oregon Congressman Earl Blumenauer introduced legislation to make a significant national investment in active transportation, towards safer, easier, and more accessible biking and walking environments for everyone. H.R. 4722, the Active Community Transportation (ACT) Act of 2010, will create a $2 billion grant program to fund networks for biking and walking that includes creating jobs, reducing traffic congestion, cuting emissions, and promoing healthy living. San Francisco would benefit from this kind of funding source to make serious gains in reshaping our streets for better everyday biking, and we need your help moving this bill forward to law -- call your US Representative today and ask her to co-sponsor H.R. 4722, for public health, for public safety, for our environment, and for the jobs it will create: Map Your Bike Trip with GoogleWe're thrilled with the news that Google has added 'bicycling' to its map. This bicycling feature will give turn-by-turn directions and help people map their route via bike lanes, bike-friendly routes and car-free paths or avoid hills. As we know, the route that your bus takes, or the streets you might drive on are not usually the same as the best biking routes. Video: Bike Camping in the Headlands As the weather gets drier, opportunities for multi-day trips by bicycle become more attractive. See how easy it is to take your family on a healthy and eco-friendly camping trip. The crew starts from the Ferry Building, heading over the Golden Gate Bridge to their destination in the Marin headlands, carrying themselves, their children, and all their equipment by bike. Cargo bikes are a great way to carry your necessary items, from children to groceries or other heavy material--through the city and beyond. Watch the video from the Xtracycle website here. You're reading the SFBC Weekly Biker BulletinGet this sent directly to your inbox by signing up here. Join the SFBC and add your voice to thousands demanding a city-wide network of bike lanes, traffic calmed streets, better access to transit and secure bike parking. Together we can make San Francisco the most bicycle friendly city in the country! | ||||


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watch the show
The latest on the Boston bombing investigation and the U.S. assessment that Bashar al-Assad's regime in Syria used chemical weapons. Also, U.S. Senator Max Baucus will not be seeking re-election. Plus, the dedication of the George W. Bush Presidential Library and Museum. Joining Gwen: Martha Raddatz, ABC News; James Kitfield, National Journal; Susan Davis, USA Today; Dan Balz, Washington Post.
In the Webcast Extra, we look at Barbara Bush's honest opinion of another Bush in the Oval Office. House Republicans faced off this week over a GOP backed health care act aimed to protect people with pre-existing conditions. Also, are we moving towards an era of commercial drones? Finally, are the defense hawks in Congress a dying breed?
Assad | Dan Balz | Dzhokhar | George W. Bush | James Kitfield | library | Martha Raddatz | Max Baucus | retirement | Susan Davis | Syria | Tamerlan |


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This Sunday, July 6, on Menifee Valley Talk Radio, soon-to-be outgoing MUSD Board Member, and soon-to-be incoming Menifee City Councilman, Fred Twyman, will be the featured guest speaking about unification.
Call in and talk to Fred about what's it's going to take to move Paloma Valley High into the menifee school district. And for those of you in Romoland, this might be an opportunity to find out what the future holds for Heritage High and the Romoland schools with the new city.
The show starts at 7:00pm, and can be listened to online at...
The phone number to call is: (646) 716-6582.
Fred Twyman to Speak About Unification
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New Online Banking Security Feature
What It Is
SCCU is dedicated to protecting you and your account information from falling into the wrong hands. We are implementing a new security feature within Online Banking, called Identity Verification, which uses questions to validate your identity before allowing access to your accounts.
How It Works
This extra layer of protection will require a one-time enrollment and will only take a few minutes to complete. When you login to Online Banking, you will be prompted to create a set of security questions with answers that only you will know. The next time you are prompted to answer a question, your answer must match the answer you set up initially before you can proceed to your account information. A feature of the Identity Verification protection is that, over time, your "typical" patterns will be known, and you will only have to answer security questions under certain circumstances, such as logging in from a different computer or conducting an unusual transaction.
Please note that participation in Identity Verification is a regulatory requirement, so this will not be an optional feature.
When This Feature Will Be Available
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Pullman porter, waiter, valet -- these don't sound like breakthrough parts, but for an African-American actor who was accustomed to producers casting white men in the roles of black people (these were the days of Amos and Andy), these parts offered a major opportunity.
Read Whole Story
In a town where relationships are the most powerful currency, if compromise hinges on an intercultural friendship between the president and Republican leaders in Congress, then middle ground will remain out of reach.
The right's strength is its ability to immerse itself in tribal warmth of sexist, racist, homophobic waters, while simply sprinkling the rest of us with their refreshing mists. And they are refreshing. Admit it.
Although the economic situation is pretty bleak for black Americans -- the economically vulnerable suffer the most when the economy tanks -- we are ushering in a time when black individual voices are paramount.
It's one thing when other African-Americans try to threaten my race card, but when people outside of my ethnicity have the audacity to question how "down" I am because of the bleak, stereotypical picture pop culture has painted for me, as a Black woman? Unacceptable.
To some, this rags to riches story reads like a fairy tale, but for Marja Vongerichten is it real life.
While Africa and America are often recognized as the book ends of the African Diaspora, there is an additional link in the Middle Passage that is less publicized, but no less important.
After gentrification the problems populating inner-city neighborhoods like Five Points aren't solved. They just relocate.
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One nice thing about being the house band on a TV show: When you've got some new shit out, you get to do a nice amount of promotion for it. The Roots, who have a plum day job at Late Night With Jimmy Fallon, just released Wise Up Ghost, their unlikely collaborative album with Elvis Costello. A couple of nights ago, Costello appeared on the show, and he and the Roots played a couple of songs together. Last night, they played a couple more. On the show proper, they performed the song "Cinco Minutos Con Vos." And as an online bonus, they also did the album's title track. This time around, they had a full string section, a bunch of backup singers, the Spanish singer Marisol, and a megaphone with them. Watch both performances below.
Wise Up Ghost is out now on Blue Note.
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Credit agency Fitch has downgraded its views of both Sony and Panasonic, dropping the two tech giants to "junk" status. Which is business speak for "don't buy shares in these two as they could go broke." Read More >>
I'm not sure if everyone is aware of the Coinage Act 1971, but due to a recent case of a disgruntled man getting into a spot of trouble for paying an £800 quid debt in coppers, I think we should all take note. Read More >>
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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3529
Braun, U; Bryce, B; Liesegang, A; Hässig, M; Bleul, U (2008). Efficacy of oral calcium and/or sodium phosphate in the prevention of parturient paresis in cows. Schweizer Archiv für Tierheilkunde, 150(7):331-338.
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The goal of this study was to investigate the efficacy of calcium chloride, sodium phosphate or a combination of these two substances administered orally immediately postpartum for the prevention of parturient paresis in cows. Thirty-two cows that had had parturient paresis at the previous calving, and in which serum biochemistry had shown hypocalcaemia and hypophosphataemia, were used in the study. The cows were transferred to the Department of Farm Animals, University of Zurich, five days before their expected due dates. On a randomized trial, the cows were given calcium chloride, sodium phosphate, both substances or no treatment (controls) via a stomach tube immediately postpartum and 12 hours later. The cows were monitored for 96 hours during which time blood was collected on a regular basis for the determination of total calcium, ionized calcium, inorganic phosphorus and magnesium concentrations. Of the 32 cows treated, 19 (59%) had parturient paresis and 13 (41%) did not. The incidence of parturient paresis did not differ significantly among the groups although there was a tendency for a lower incidence in cows treated with both calcium chloride and sodium phosphate. The various treatments had no apparent effect on serum calcium concentration. The concentration of inorganic phosphorus increased significantly in cows treated with sodium phosphate compared with the controls. The results of this study showed that cows treated with both calcium chloride and sodium phosphate orally tended to have a lower incidence of parturient paresis. Further investigation into multiple administrations of oral calcium chloride and sodium phosphate, started before parturition, for the prevention of parturient paresis is required.
Other titles: | Untersuchungen zur Prophylaxe der Gebärparese mit Kalzium und Natriumphosphat per os |
Item Type: | Journal Article, refereed, original work |
Communities & Collections: | 05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Division of Herd Health 05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Clinic for Reproductive Medicine 05 Vetsuisse Faculty > Institute of Animal Nutrition 05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Clinic for Ruminants |
DDC: | 570 Life sciences; biology 630 Agriculture |
Language: | German |
Date: | July 2008 |
Deposited On: | 03 Sep 2008 11:01 |
Last Modified: | 27 Nov 2013 21:13 |
Publisher: | Hans Huber |
Additional Information: | Diese Artikelfassung entspricht nicht vollständig dem in der Zeitschrift veröffentlichten Artikel. Dies ist nicht die Originalversion des Artikels und kann daher nicht zur Zitierung herangezogen werden. |
Publisher DOI: | 10.1024/0036-7218.104.22.1681 |
PubMed ID: | 18714936 |
Citations: | Web of Science®. Times Cited: 1 Google Scholar™ |
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July 26, 2012
Steven Deeks, Daniel Kuritzkes, and David Margolis (photo: Deborah W. Campos). |
Three research teams have shared promising findings in the search for a cure this week at AIDS 2012. "I think today might be considered the day when the cure research agenda moves from the basic science lab into the clinic," said Steven Deeks of the University of California, San Francisco, in a press conference on Thursday.
Harvard University's Daniel Kuritzkes described two HIV-positive individuals who underwent bone marrow stem cell transplants for the treatment of lymphoma (a type of cancer). The procedure was similar to the one that appears to have cured "Berlin Patient" Timothy Brown, but with a couple of key differences.
First, unlike in Brown's case, the transplanted cells did not come from a donor with the genetic mutation (known as CCR5-delta-32) that renders immune system cells resistant to HIV. (While any such transplant is still an arduous and expensive procedure, at least these didn't rely on finding a bone marrow donor who is both a good match for the recipient and a carrier of a rare genetic mutation.) Second, both individuals received a milder form of pre-transplant chemotherapy than did Brown, which allowed them to continue taking their antiretroviral therapy during the transplant period, Kuritzkes explained.
Although both had detectable HIV immediately following their transplants, over time the transplanted donor cells replaced the two individuals' HIV-infected immune system cells. Nearly two years later for one individual and three and a half years later for the other, sensitive tests have detected no traces of the virus in their blood plasma or CD4 cells. Levels of antibodies to HIV have also significantly declined, as would be expected with fewer copies of the virus in the body.
These individuals' new immune system cells are fully susceptible to HIV, said Kuritzkes, but his research team believes that the transplanted cells escaped HIV infection because antiretroviral therapy was maintained before, during, and after the transplant -- "a form of PrEP at the cellular level," Kuritzkes said. These data "provide another piece of the puzzle as we continue our work towards a cure that will be generalizable and applicable to HIV patients worldwide."
David Margolis of The University of North Carolina at Chapel Hill presented data on the use of the chemotherapy drug vorinostat to reach reservoirs of hidden HIV in "latently infected" CD4 cells. Ordinarily, HIV-invaded cells are killed by other immune system cells whose job is to snuff out infected cells in the body. CD4 cells that are inactive or "resting," however, are essentially invisible to the rest of the immune system, which allows these viral reservoirs to last for years. In addition, the HIV hiding out in these latently infected cells is not replicating (making new copies of itself); because currently available antiretrovirals only work by interrupting various stages in the replication process, the drugs are harmless to the non-replicating cells in these reservoirs.
In Margolis' study, eight HIV-positive people took a single dose of vorinostat in addition to their HIV meds. When the researchers then checked the individuals' resting CD4 cell populations, they found that signs of hidden virus increased significantly following administration of vorinostat, suggesting that this drug is able to "force the virus out into the open" where it can be targeted by antiretroviral drugs and other therapies. "The next steps that need to be done in the field," Margolis concluded, "are to understand how this can be done repeatedly and completely effectively with all the reservoir cells in the body, completely prevent infection of new cells, and perhaps also find ways to rapidly and efficiently kill or clear these infected cells."
In a third promising study, described by Asier Saez-Ciron of France's Pasteur Institute, researchers assessed whether early antiretroviral therapy might be employed to mimic the ability of some people -- nicknamed "elite controllers" -- to keep their HIV in check without treatment.
Saez-Ciron and his colleagues have to date identified 20 individuals in France whose HIV remained suppressed even after they stopped antiretroviral therapy; 14 of them are taking part in what's been dubbed the Visconti study. "The most interesting characteristic in all these 14 patients is that they were treated very early after their infection," said Saez-Ciron; the median (most common) timeframe was 40 days after acquiring the virus. After taking HIV meds for a median of three years, these individuals have now spent a median of seven years off treatment.
The researchers discovered that, like elite controllers, members of the Visconti cohort have small viral reservoirs that are decreasing over time, even without HIV treatment. "Very interestingly," said Saez-Ciron, "in patients in the Visconti study, the larger contribution of cells in the viral reservoir is cells that are shorter-lived" rather than the usual long-lasting cells, leading to a gradual decrease in the viral reservoir as the cells die off.
Following this clue, the researchers studied a broader sample of individuals to see how frequently this arrangement appears. Their preliminary work has found that between 5% and 15% of people who started HIV treatment very early and who stayed on treatment for at least 12 months are benefiting from the same arrangement of short- and long-lived cells in their viral reservoirs.
As Steven Deeks observed in his introduction to the press conference, this essentially represents a "functional cure" -- a cure that does not eradicate HIV from the body yet allows the virus to be suppressed without medication and without the risk of progression to AIDS.
All three studies, Deeks said, "provide reason for enthusiasm that ultimately we're going to get to where we need to go, which is a way to cure people with HIV infection."
Click here to watch a video of the press conference on HIVandHepatitis.com.
No comments have been made.
Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here. |


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General Principles of Discipline While every child is different, most children need to be given consistent, clear rules and expectations about behavior. The following are some general principles about discipline: Discipline needs to begin as soon as the child is mobile--pulling up and crawling. Young infants rely on their parents to provide a safe environment. Discipline should be age-focused and should teach age-appropriate behaviors. Try to recognize and praise your child when he or she is being good. Be a good role model for your child. After the discipline occurs, hug your child. Make sure the child knows it is the behavior you are not happy with, not the child. Physical punishment is not needed or appropriate. Rewards for good behavior should be immediate. Decrease unwanted behavior It is important to remember not to reward a child or give positive reinforcement for a bad behavior. For example, if a child is having a temper tantrum, giving him or her a cookie to be quiet is rewarding the child for the bad behavior. In order to help decrease the chance of bad behavior, consider the following: Do not reinforce the behavior; simply ignore the child. The behavior may have to result in an unpleasant consequence, such as punishment. Active punishment has two forms, including the following: Denying the child privileges or desired activities, such as decreasing TV time or no dessert Undesirable or uncomfortable activities can be required of the child, such as doing chores or having "time-out" The behavior can result in natural consequences. For example, a child who will not eat may go to bed hungry. It is generally accepted that spanking and other forms of physical punishment are not helpful. These types of discipline teach the child aggressive behaviors and poor conflict management. Methods of discipline Discipline methods often depend on the age of the child, and how much the child understands his or her behavior. The following are some suggestions for discipline techniques for each age group: Infants and toddlers: Safety is the main concern. Infants will respond to a loud, firm voice saying "no." Provide a safe environment that decreases the chances of things being broken by the child. After saying "no," direct your child to an acceptable behavior, such as a toy. Do not reward bad behavior. Ignore temper tantrums, but confront other problems, such as biting or hitting. Praise and reward good behavior. Preschoolers: Preschoolers need clear and consistent rules. This age group needs time to prepare for the next activity. Give your child a warning before it is time to stop playing. Preschoolers need lots of explanation as to why things are being done. Use time-out for bad behavior. Use praise for good behavior. School-aged children. School-aged children need the above rules and guidelines plus the following: Give your child chances to explain his or her side and opinion and opportunities to express his or her feelings and concerns. Give your child choices. Give your child chances to help solve problems together regarding his or her behavior. Adolescents: This age group needs patient and understanding parents as they test all limits. Adolescents need to be told the long-term outcomes of bad behaviors. Adolescents need to be involved with limit-setting, based on their maturity.
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This easy spaghetti recipe will amaze you with it's simplicity. It is full flavoured and can be easily made from pantry items.You can have it on the table in less than 20 minutes.
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Drain tuna, flake apart and reserve oil.
In a hot fryan add 4 tablespoons of the tunas oil and fry the garlic for 2 mins.
Add the cooked spaghetti and stir to coat in the oil. Add fresh tomatoes, flaked tuna and olives.
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Tamarind Art Council
Address | 142 East 39th Street, New York, NY, United States |
Category | Arts Council | |||||
Phone | 212.200.8000 | |||||
Website | http://www.tamarindart.org |
Tamarind Art Council (TAC) is a not-for-profit 501(c)(3) organization dedicated to promoting contemporary art in North America. Our focus is to support all types of artistic expression, including performing and fine arts, by sponsoring art-related activities and cross-cultural events in order to expand the audience for art and culture. Our mission: Tamarind Art Council exemplifies how life can revolve around the arts. Our mission is to inspire the work of contemporary artists and performers and to facilitate public appreciation for these unique cultural art forms. Some of our events include art... [more]


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Mar 04, 2014
Ten CIA grads talk about automotive design careers in three new videos
cia exhibition
Feb 14, 2014
2014 Student Independent Exhibition
Feb 28, 2014
Progressive acquires artwork by CIA instructor Dan Tranberg
cia exhibition
Mar 28, 2014
Dinner by Design Art of the Table, and a runway show
about 12 hours ago via Facebook
CIA congratulates Sreshta Rit Premnath 03, whose solo show at KANSAS GALLERY in New York City was a criticspick in the prestigious journal, Art Forum. Read the review here: http://ow.ly/utVXH
Feb 19, 2014
Photography major captures images on hand-blown glass
cia exhibition
Mar 28, 2014
The Accident: Recent Work by Nicky Nodjoumi
Feb 14, 2014
Glass major wins award in Niche magazine competition
Apr 22, 2014 @ Museum of Contemporary Art Cleveland in Cleveland, OH
2014 Spring Design Show
Mar 11, 2014
3/13-17: Ikiru, To the Wonder, Escape from Tomorrow & more!
Aug 20, 2013
CIA named one of the "Best in the Midwest"
cia exhibition
Apr 22, 2014
CIA Spring Runway Show
Admissions . Contest . Jurors
Degree MFA Clemson University, Printmaking; BA Xavier University, Printmaking, Graphic Design & Business
Maggie is an Associate Professor and Printmaking Department Chair. She is a founding member and Board President of the Morgan Conservatory, a center for book and paper arts. http://morganconservatory.org
Recent exhibitions include a solo exhibition at the University of Mount Union and inclusion in the 2013 MAPC Juried Members Exhibition at the McDonough Museum.
Degree MFA, Jewelry and Metalsmithing, Tyler School of Art, Temple University;
BS, Art and French, University of Wisconsin-Madison
Matthew Hollern has received research and professional development grants from the Society of North American Goldsmiths, Lilly Foundation, John and Maxeen Flower Fund, CIA, Community Partnership for Arts and Culture - Creative Workforce Fellowship, and two Artist Fellowships from the Ohio Arts Council. His work is included in the Smithsonian American Art Museum, Design Museum Helsinki - Finland, the Vatican Archive, the Ohio Crafts Museum, the Cleveland Art Association, and others.
Degree MFA Photography, Bard College; BFA Photography, Cleveland Institute of Art
Nancy McEntee is a Professor of Photography and Chair of the Photography & Video department at the Cleveland Institute of Art. She received her Master of Fine Arts degree in photography from The Milton Avery Graduate School for the Arts at Bard College and her Bachelor of Fine Arts degree in photography from the Cleveland Institute of Art.
Nancy is a recipient of a Creative Workforce Fellowship from the Community Partnership for Arts and Culture. She was awarded a residency at The Burren College of Art in Co. Clare, Ireland for summer 2010. She has also received a Virginia Center For the Creative Arts Fellowship Residency and an Ohio Arts Council Individual Artist Fellowship. Her photographs are exhibited nationally and can be found in many public and private collections.
Degree BFA, Cleveland Institute of Art
Anthony Scalmato is the Department Chair of Animation and an Assistant Professor at the Cleveland Institute of Art. He has created more than a hundred published works which have been viewed on television, web and mobile devices. Before joining CIA, Scalmato worked as a Senior Creative Developer at American Greetings where he provided animations, illustrations and art direction for products that are viewed globally by millions of people every month. His clients include Applebee's, Disney, Pixar, Sony, UPS, Taylor Swift, Wal-mart, M & M's, Ferraro Chocolates and many other fortune 500 companies.
In 2011 Scalmato was awarded the American Greetings Chairman's Award for Creativity and Innovation. He has also received over a dozen "Best Animation" awards from film festivals around the world. In addition to teaching, he continues to work as a freelance artist for many clients and as a contractor for American Greetings.
Degree MFA from Clemson University in the discipline of painting and a BA from Michigan State University in ceramics.
Tommy White, born in Detroit, received his M.F.A. from Clemson University in the discipline of painting and a B.A. from Michigan State University in ceramics. His work is included in many private collections as well as the permanent collections of the Mobile Museum of Art in Alabama, Binney and Smith, Inc. (former manufacturer of Liquitex products), and the Capital One Corporation. He has exhibited in nineteen states, the District of Columbia, Melbourne, Australia, and Seoul, South Korea. Prior to becoming Assistant Professor of Painting at the Cleveland Institute of Art, he spent three years teaching painting and drawing at the University of Oklahoma and nine years with Virginia Commonwealth University as an educator and administrator. He maintains a professional working studio in Cleveland Heights, Ohio.
Degree MFA, Northwestern University; Post-Bach, School of the Art Institute of Chicago; BA, University of Michigan
Designer, writer, amateur historian and nascent bread baker, Mari has been involved with information design and publication design (in all it's myriad forms) throughout her practice. Clients have included Cooper Hewitt National Design Museum, The Case Connection Zone, Artist Carl Pope, and Internationals Public Schools. She received a 2013 Ohio Arts Council Grant for Individual Excellence with one of her principle collaborators, Mary Jo Toles (Professor of Photography at CIA). She has also taught at Parsons School of Design, University of California (Los Angeles), and U Cal (Santa Barbara).
Current projects include a writing project about information and design, an interactive visualization of the effect of life style changes on Type 2 Diabetes and a fierce wild yeast starter for her crusty sourdough loaves. She is eagerly awaiting the arrival of Chad Robertson's latest book, which promises to be about whole grain wild yeast breads.
Recent Awards:
2013 Ohio Arts Council Award for Individual Excellence
Upcoming Talks:
The Next Next: Design and Big Data, The 2013 National Conference of Editors and Designers, The Federal Reserve
In The Thick Of It: Collaboration in Contemporary Design and Art, The Twenty-Seventh Annual National Conference On Liberal Arts and The Education Of Artists, School of Visual Arts, New York