text:
All very good advice swanks!
All very good advice swanks!
PES REPRESENTATIVEpescience.com
Thanks for the invite! Good luck, l1fe!
Squats do a booty good.
Purus labs Rep
doin it mountain dog style in here come along for the shred fest-http://anabolicminds.com/forum/workout-logs/229302-danbs-mountain-dog.html
very nice point dan..I think some gyno out there is "self-induced" in such manner
along those lines - while on cycle, I like exemestane for that, if issues begin
and i'm not a big fan of nolva, unless a very aggressive case of gyno presents (or is preX)
other than that, everything looks kosher in here
all right iowa, let's see what you got
FINAFLEX Product Educator
visit our website at finaflex.com
contact me at email@example.com
Where it all started
Beat me to it. If a lump forms blast it with letro at 2.5mg/day for 3-4 days then 1.25mg/day for a week all the while take 20mg Nova per day and keep it through the remainder of the cycle.
Should look like this
First 3 days:
Letro 2.5/2.5/2.5
Nolva 20/20/20
Following 7 days:
Letro: 1.25mg/day
Nolva: 20mg/day
Continue Nolva at 20mg/day remainder of cycle.
Formutech Nutrition Rep----------------Check out my new AMPitropin log:
www.formutechnutrition.com------------- http://goo.gl/4rJf9K
Good info up in here!
Live Hard, Laugh Hard, Love Hard and Heal Fast! - KLEEN
Formutech Nutrition Rep----------------Check out my new AMPitropin log:
www.formutechnutrition.com------------- http://goo.gl/4rJf9K
It takes tons of research and cycle experience to learn what I just read on these 2 pages. Good stuff!
In for gains!
I am all that is MAN!
MAN Sports Forum Rep
Crazy MAN Sports deals here: http://bit.ly/IFDFTA
Okay just want to let you all know what my workouts are looking like. I decided that since I would have a faster recovery rate I wanted to do a full body workout every other day. And since I workout in the early AM (5:30) it gives me more days to get sleep instead of the 5x a week I was doing. Basically, I do 2 sets of a compound exercise with a weight that I can get 12-15 reps with. I use a 2-0-2 tempo roughly. Then I do one set of an isolated exercise for 10-12 reps with a 3-1-3 tempo to get a good stretch and pump in the muscle. I've been doing this for about 2 months now and I'm really liking it.
Squats 2x12 2-0-2
Single Leg Ext 1x10 3-1-3
Rev Grip Pull Down 2x12
Straight-arm Push Down 1x10
DB Bench Press 2x12
Single-arm Lower Cable Chest Raise 1x10
Butterfly Machine 1x10
Deadlift 1x12 (depending on how I feel I may do another set)
Standing Leg Curl 1x10
Lying Single Leg Curl 1x10
Standing Calf Raises 1x10
HS Behind-neck Press 2x12
DB Shoulder Press 1x10
DB Lat Raise 1x10
Cable Seated Row 2x12
Reverse Machine Fly 1x10
Every time I go in I put 5-10lbs more weight on the compound lifts and try to beat the calculated 1RM from last w/o. If I'm not able to then I'll stay with that weight until i do. Once I get down to only hitting 8-10 reps on an exercise, I'm going to throw in another set and then again when I get down to 3-5. The iso movements I'll just adjust depending on how I'm feeling it. They are really just for the stretch and pump of the muscle.
Please tell me what you think!
Where it all started
Where it all started


text:
I have been searching high and low and I cant seem to find an up to date post that doesn't involve using Gizmo5 to accomplish what im about to request
My house has terrible signal, I cant afford a Verizon extender at the moment, so I have been looking into using my WiFi for making and receving calls from my Google Voice number.
I was reading up that this was accomplished using Fring and Gizmo5 some time ago, but Gizmo5 is now closed as a Google Project.
Any ideas? I had Skype and that doesn't allow WiFi calling...

subset: commoncrawl


text:
Publications (77)597.51 Total impact
Article: Human Rab7 mutation mimics features of Charcot–Marie–Tooth neuropathy type 2B in Drosophila
[show abstract] [hide abstract]
ABSTRACT: Charcot-Marie-Tooth Disease type 2B (CMT2B) is an inherited axonal peripheral neuropathy. It is characterised by prominent sensory loss, often complicated by severe ulcero-mutilations of toes or feet, and variable motor involvement. Missense mutations in RAB7A, the gene encoding the small GTPase Rab7, cause CMT2B and increase Rab7 activity. Rab7 is ubiquitously expressed and is involved in degradation through the lysosomal pathway. In the neurons, Rab7 plays a role in the long-range retrograde transport of signalling endosomes in the axons. Here we developed the first animal model of CMT2B, modelling one of the mutations (L129F) in Drosophila melanogaster. Behavioural assays show that this model recapitulates several hallmarks of the human disease. Upon expression of mutant Rab7 in the sensory neurons, larvae present with a reduction of temperature and pain perception. Furthermore, the larvae exhibit a crawling defect when the mutant protein is expressed in the motor neurons. Analysis of axonal transport of Rab7 positive vesicles in sensory neurons of Drosophila larvae and in neurites of mammalian neuroblastoma cells demonstrates that mutant vesicles pause less than their wild-type counterparts. This latter finding indicates that alterations in vesicle transport might contribute to the pathomechanism of CMT2B.Neurobiology of Disease 01/2014; · 5.62 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Dominant congenital spinal muscular atrophy (DCSMA) is a disorder of developing anterior horn cells and shows lower-limb predom-inance and clinical overlap with hereditary spastic paraplegia (HSP), a lower-limb-predominant disorder of corticospinal motor neurons. We have identified four mutations in bicaudal D homolog 2 (Drosophila) (BICD2) in six kindreds affected by DCSMA, DCSMA with upper motor neuron features, or HSP. BICD2 encodes BICD2, a key adaptor protein that interacts with the dynein-dynactin motor complex, which facilitates trafficking of cellular cargos that are critical to motor neuron development and maintenance. We demonstrate that mutations resulting in amino acid substitutions in two binding regions of BICD2 increase its binding affinity for the cytoplasmic dynein-dynactin complex, which might result in the perturbation of BICD2-dynein-dynactin-mediated trafficking, and impair neurite outgrowth. These findings provide insight into the mechanism underlying both the static and the slowly progressive clinical features and the motor neuron pathology that characterize BICD2-associated diseases, and underscore the importance of the dynein-dynactin transport pathway in the development and survival of both lower and upper motor neurons. Spinal muscular atrophies (SMAs) are a clinically and genetically heterogeneous group of disorders affecting motor neurons of the anterior horn of the spinal cord. The most common form of SMA is caused by autosomal-recessive mutations in survival of motor neuron 1 (SMN1 [MIM 600354]). Severe cases present in infancy with pro-gressive weakness of proximal and axial muscles and early death. In contrast, autosomal-dominant congenital SMA (DCSMA) is characterized by nonprogressive congenital or early-onset lower-limb-predominant weakness 1–3 and often results in significant mobility impairment. Heredi-tary spastic paraplegia (HSP) is also a heterogeneous predominantly lower-limb disorder that affects the upper (corticospinal) motor neurons (UMNs). Onset is usually in adulthood, and clinical features are progressive. 4 Many forms of DCSMA and HSP remain geneticallyThe American Journal of Human Genetics 05/2013; · 11.20 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Mutations in the serine palmitoyltransferase subunit 1 (SPTLC1) gene are the most common cause of hereditary sensory neuropathy type 1 (HSN1). Here we report the clinical and molecular consequences of a particular mutation (p.S331Y) in SPTLC1affecting a patient with severe, diffuse muscle wasting and hypotonia, prominent distal sensory disturbances, jointhypermobility, bilateral cataracts and considerable growth retardation. Normal plasma sphingolipids were unchanged but 1-deoxy-sphingolipids were significantly elevated.In contrast to other HSN patients reported so far, our findings strongly indicate that mutations at amino acid position Ser331 of the SPTLC1 gene lead to a distinct syndrome.European journal of medical genetics 02/2013; · 1.57 Impact Factor - · 35.21 Impact Factor
Article: Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy.
[show abstract] [hide abstract]
ABSTRACT: BACKGROUND: Mutations in inverted formin, FH2, and WH2 domain containing (INF2) are common causes of dominant focal segmental glomerulosclerosis. INF2 encodes a member of the diaphanous-related formin family, which regulates actin and microtubule cytoskeletons. Charcot-Marie-Tooth neuropathy (CMT) is a group of inherited disorders affecting peripheral neurons. Many reports have shown that glomerulopathy can associate with CMT. However, it has been unclear whether these two processes in the same individual represent one disorder or if they are two separate diseases. CASE DIAGNOSIS/TREATMENT: Recently, INF2 mutations were identified in 12 of 16 patients with CMT-associated glomerulopathy, suggesting that these mutations are a common cause of the dual phenotype. In this study, we report two cases of CMT-associated glomerulopathy that both showed INF2 mutations. A novel INF2 mutation, p. L77P, was identified in a family in which the dual phenotype was inherited in a dominant fashion. The pathogenic effect of p. L77P was proposed using a structural homology model. In addition, we identified a patient with a sporadic CMT-associated glomerulopathy carrying a known INF2 mutation: p. L128P. CONCLUSIONS: Our study confirms the link between INF2 mutations and CMT-associated glomerulopathy and widens the spectrum of pathogenic mutations.Pediatric Nephrology 09/2012; · 2.94 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Inherited peripheral neuropathies are frequent neuromuscular disorders known for their clinical and genetic heterogeneity. In 33 families, we identified 8 mutations in HINT1 (encoding histidine triad nucleotide-binding protein 1) by combining linkage analyses with next-generation sequencing and subsequent cohort screening of affected individuals. Our study provides evidence that loss of functional HINT1 protein results in a distinct phenotype of autosomal recessive axonal neuropathy with neuromyotonia.Nature Genetics 09/2012; 44(10):1080-3. · 35.21 Impact Factor -
Article: Exome sequencing identifies a REEP1 mutation involved in distal hereditary motor neuropathy type V.
[show abstract] [hide abstract]
ABSTRACT: The distal hereditary motor neuropathies (dHMNs) are a heterogeneous group of neurodegenerative disorders affecting the lower motoneuron. In a family with both autosomal-dominant dHMN and dHMN type V (dHMN/dHMN-V) present in three generations, we excluded mutations in all genes known to be associated with a dHMN phenotype through Sanger sequencing and defined three potential loci through linkage analysis. Whole-exome sequencing of two affected individuals revealed a single candidate variant within the linking regions, i.e., a splice-site alteration in REEP1 (c.304-2A>G). A minigene assay confirmed complete loss of splice-acceptor functionality and skipping of the in-frame exon 5. The resulting mRNA is predicted to be expressed at normal levels and to encode an internally shortened protein (p.102_139del). Loss-of-function REEP1 mutations have previously been identified in dominant hereditary spastic paraplegia (HSP), a disease associated with upper-motoneuron pathology. Consistent with our clinical-genetic data, we show that REEP1 is strongly expressed in the lower motoneurons as well. Upon exogeneous overexpression in cell lines we observe a subcellular localization defect for p.102_139del that differs from that observed for the known HSP-associated missense mutation c.59C>A (p.Ala20Glu). Moreover, we show that p.102_139del, but not p.Ala20Glu, recruits atlastin-1, i.e., one of the REEP1 binding partners, to the altered sites of localization. These data corroborate the loss-of-function nature of REEP1 mutations in HSP and suggest that a different mechanism applies in REEP1-associated dHMN.The American Journal of Human Genetics 06/2012; 91(1):139-45. · 11.20 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Hereditary spastic paraplegias (HSP) are a heterogeneous group of neurological disorders. Insidiously progressive spastic weakness of the lower extremities is the common criterion in all forms described. Clinically, HSP is differentiated into pure (uncomplicated) and complex (complicated) forms. While pure HSP is predominantly characterized by signs and symptoms of pyramidal tract dysfunction, additional neurological and non-neurological symptoms occur in complicated forms. Autosomal dominant, autosomal recessive, and X-linked modes of inheritance have been described and at least 48 subtypes, termed SPG1-48, have been genetically defined. Although in autosomal dominant HSP families 50-60% of etiologies can be established by genetic testing, genotype predictions based on the phenotype are limited. In order to realize high-throughput genotyping for dominant HSP, we designed a resequencing microarray for six autosomal dominant genes on the Affymetrix CustomSEQ array platform. For validation purposes, 10 previously Sanger sequenced patients with autosomal dominant HSP and 40 positive controls with known mutations in ATL1, SPAST, NIPA1, KIF5A, and BSCL2 (32 base exchanges, eight small indels) were resequenced on this array. DNA samples of 45 additional patients with AD spastic paraplegia were included in the study. With two different sequencing analysis software modules (GSEQ, SeqC), all missense/nonsense mutations in the positive controls were identified while indels had a detection rate of only 50%. In total, 244 common synonymous single-nucleotide polymorphisms (SNPs) annotated in dbSNP (build 132) corresponding to 22 distinct sequence variations were found in the 53 analyzed patients. Among the 22 different sequence variations (SPAST n = 15, ATL1 n = 3, KIF5A n = 2, HSPD1 n = 1, BSCL2 n = 1, NIPA1 n = 0), 12 were rare variants that have not been previously described and whose clinical significance is unknown. In SPAST-negative cases, a genetic diagnosis could be established in 11% by resequencing. Resequencing microarray technology can therefore efficiently be used to study genotypes and mutations in large patient cohorts.Neurogenetics 05/2012; 13(3):215-27. · 3.58 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Hereditary spastic paraplegia (SPG) is a clinically and genetically heterogeneous group of neurodegenerative disorders that are clinically characterised by progressive spasticity and weakness of the lower-limbs (pure SPG) and, majoritorian, additional more extensive neurological or non-neurological manifestations (complex or complicated SPG). Pure SPG is characterised by progressive spasticity and weakness of the lower-limbs, and occasionally sensory disturbances or bladder dysfunction. Complex SPGs additionally include cognitive impairment, dementia, epilepsy, extrapyramidal disturbances, cerebellar involvement, retinopathy, optic atrophy, deafness, polyneuropathy, or skin lesions in the absence of coexisting disorders. Nineteen SPGs follow an autosomal-dominant (AD-SPG), 27 an autosomal-recessive (AR-SPG), 5 X-linked (XL-SPG), and one a maternal trait of inheritance. SPGs are due to mutations in genes encoding for proteins involved in the maintenance of corticospinal tract neurons. Among the AD-SPGs, 40-45% of patients carry mutations in the SPAST-gene (SPG4) and 10% in the ATL1-gene (SPG3), while the other 9 genes are more rarely involved (NIPA1 (SPG6), KIAA0196 (SPG8), KIF5A (SPG10), RNT2 (SPG12), SPGD1 (SPG13), BSCL2 (SPG17), REEP1 (SPG31), ZFYVE27 (SPG33, debated), and SLC33A1 (SPG42, debated)). Among the AR-SPGs, ~20% of the patients carry mutations in the KIAA1840 (SPG11) gene whereas the 15 other genes are rarely mutated and account for SPGs in single families yet (CYP7B1 (SPG5), SPG7 (SPG7), ZFYVE26 (SPG15), ERLIN2 (SPG18), SPG20 (SPG20), ACP33 (SPG21), KIF1A (SPG30), FA2H (SPG35), NTE (SPG39), GJA12/GJC2 (SPG44), KIAA0415 (SPG48) and 4 genes encoding for the AP4-complex (SPG47)). Among the XL-SPGs, 3 causative genes have been identified (L1CAM (SPG1), PLP1 (SPG2), and SLC16A2 (SPG22)). The diagnosis of SPGs is based on clinical, instrumental and genetic investigations. Treatment is exclusively symptomatic.Journal of the neurological sciences 05/2012; 318(1-2):1-18. · 2.32 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Inherited disorders characterized by motor neuron loss and muscle weakness are genetically heterogeneous. The recent identification of mutations in the gene encoding transient receptor potential vanilloid 4 (TRPV4) in distal spinal muscular atrophy (dSMA) prompted us to screen for TRPV4 mutations in a small group of children with compatible phenotype. In a girl with dSMA and vocal cord paralysis, we detected a new variant (p.P97R) localized in the cytosolic N-terminus of the TRPV4 protein, upstream of the ankyrin-repeat domain, where the great majority of disease-associated mutations reside. In another child with congenital dSMA, in this case associated with bone abnormalities, we detected a previously reported mutation (p.R232C). Functional analysis of the novel p.P97R mutation in a heterologous system demonstrated a loss-of-function mechanism. Protein localization studies in muscle, skin, and cultured skin fibroblasts from both patients showed normal protein expression. No TRPV4 mutations were detected in four children with dSMA without bone or vocal cord involvement. Adding to the clinical and molecular heterogeneity of TRPV4-associated diseases, our results suggest that molecular testing of the TRPV4 gene is warranted in cases of congenital dSMA with bone abnormalities and vocal cord paralysis.Neurogenetics 04/2012; 13(3):195-203. · 3.58 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: The second lumbrical-interosseus distal motor latency (2LI-DML) was compared prospectively in 450 hands. Median nerve function was assessed by standard motor and sensory electrophysiological tests. In a control group of 100 hands the upper limit of normal for the 2LI-DML was 0.5 ms. In all hands studied the correlation coefficients of 2LI-DML were higher with sensory nerve tests than with motor studies. Carpal tunnel syndrome (CTS) was diagnosed clinically in 276 hands, and 174 showed no clinical signs of CTS. The 2LI-DML was prolonged in 269 of the 276 hands, with clinical signs of CTS and normal in 170 of 174 non-CTS hands. Thus the 2LI-DML resulted in a sensitivity of 97.5 %. On the other hand, combining the standard tests yielded a sensitivity of 98.5 %. In 31 of 36 additional hands a lumbrical response was recorded, although motor and sensory responses form standard median nerve conduction studies were absent, and the 2LI-DML was substantially prolonged. The 2LI-DML therefore represents a highly sensitive, fast, easy-to-perform, and cost-efficient method to study median nerve function across the wrist and may help to localize the lesion in cases in which standard electrophysiological methods fail.Journal of Neurology 04/2012; 247(7):530-534. · 3.58 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Ryanodine receptor 1 (RYR1) mutations are a common cause of congenital myopathies associated with both dominant and recessive inheritance. Histopathological findings frequently feature central cores or multi-minicores, more rarely, type 1 predominance/uniformity, fiber-type disproportion, increased internal nucleation, and fatty and connective tissue. We describe 71 families, 35 associated with dominant RYR1 mutations and 36 with recessive inheritance. Five of the dominant mutations and 35 of the 55 recessive mutations have not been previously reported. Dominant mutations, typically missense, were frequently located in recognized mutational hotspot regions, while recessive mutations were distributed throughout the entire coding sequence. Recessive mutations included nonsense and splice mutations expected to result in reduced RyR1 protein. There was wide clinical variability. As a group, dominant mutations were associated with milder phenotypes; patients with recessive inheritance had earlier onset, more weakness, and functional limitations. Extraocular and bulbar muscle involvement was almost exclusively observed in the recessive group. In conclusion, our study reports a large number of novel RYR1 mutations and indicates that recessive variants are at least as frequent as the dominant ones. Assigning pathogenicity to novel mutations is often difficult, and interpretation of genetic results in the context of clinical, histological, and muscle magnetic resonance imaging findings is essential.Human Mutation 02/2012; 33(6):981-8. · 5.21 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Mutations in atlastin-1 (ATL-1), a gene known to cause pure, early-onset autosomal dominant hereditary spastic paraplegia SPG3A, have been recently reported to cause hereditary sensory neuropathy I (HSN I). We describe the detailed clinical and electrophysiologic findings in the first family with ulcero-mutilating sensory neuropathy carrying the c. C1065A, p.N355K mutation in ATL-1. Detailed clinical and electrophysiologic studies were performed in affected and at-risk family members. Motor and sensory nerve conductions studies (NCS) were carried out in upper and lower limbs. ATL-1 was screened for mutations by direct sequencing. Ten patients were found to carry the N355K mutation. With the exception of the two youngest patients, all had trophic skin changes in the feet consisting mainly of painless ulcers. Frequently, amputation of toes, feet, or even more proximal parts of the lower legs became necessary. A variable degree of increased muscle tone was observed in younger patients, whilst some older affected individuals only presented with hyperreflexia of patellar tendon reflexes. NCS revealed signs of an axonal motor and sensory neuropathies. Our family carrying the N355K ATL1 mutation, which was initially diagnosed as HSN I, enlarges the SPG3A phenotype. We therefore suggest that patients with HSN I excluded for more common causes of HSN I, and in particular, affected individuals who exhibit additional pyramidal tract features should also be screened for mutations in ATL1.European Journal of Neurology 02/2012; 19(7):992-8. · 4.16 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Multiplex ligation-dependent probe amplification (MLPA) has become a standard method for identifying copy number mutations in diagnostic and research settings. The occurrence of false-positive deletion findings and the underlying causes are well recognized, whereas false-positive duplication/amplification findings have not been appreciated so far. We here present three pertinent cases which were only identified on extended, nonstandard secondary analyses. We also offer and experimentally validate a potential explanation. Our findings imply that MLPA data indicating gain of genomic sequence require validation on an independent sample or by an independent method.Analytical Biochemistry 02/2012; 421(2):799-801. · 2.58 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Multiplex ligation-dependent probe amplification (MLPA) has become a standard method for identifying copy number mutations in diagnostic and research settings. The occurrence of false-positive deletion findings and the underlying causes are well recognized, whereas false-positive duplication/amplification findings have not been appreciated so far. We here present three pertinent cases which were only identified on extended, nonstandard secondary analyses. We also offer and experimentally validate a potential explanation. Our findings imply that MLPA data indicating gain of genomic sequence require validation on an independent sample or by an independent method.Anal Biochem. 2012 Feb 15;. Epub 2011 Dec 9. 02/2012; 421(2):799-801. - [show abstract] [hide abstract]
ABSTRACT: Considerable non-allelic heterogeneity for autosomal recessively inherited Charcot-Marie-Tooth (ARCMT) disease has challenged molecular testing and often requires a large amount of work in terms of DNA sequencing and data interpretation or remains unpractical. This study tested the value of SNP array-based whole-genome homozygosity mapping as a first step in the molecular genetic diagnosis of sporadic or ARCMT in patients from inbred families or outbred populations with the ancestors originating from the same geographic area. Using 10 K 2.0 and 250 K Nsp Affymetrix SNP arrays, 15 (63%) of 24 CMT patients received an accurate genetic diagnosis. We used our Java-based script eHoPASA CMT-easy Homozygosity Profiling of SNP arrays for CMT patients to display the location of homozygous regions and their extent of marker count and base-pairs throughout the whole genome. CMT4C was the most common genetic subtype with mutations detected in SH3TC2, one (p.E632Kfs13X) appearing to be a novel founder mutation. A sporadic patient with severe CMT was homozygous for the c.250G > C (p.G84R) HSPB1 mutation which has previously been reported to cause autosomal dominant dHMN. Two distantly related CMT1 patients with early disease onset were found to carry a novel homozygous mutation in MFN2 (p.N131S). We conclude that SNP array-based homozygosity mapping is a fast, powerful, and economic tool to guide molecular genetic testing in ARCMT and in selected sporadic CMT patients.Journal of Neurology 09/2011; 259(3):515-23. · 3.58 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Early onset hereditary motor and sensory neuropathies are rare disorders encompassing congenital hypomyelinating neuropathy with disease onset in the direct post-natal period and Dejerine-Sottas neuropathy starting in infancy. The clinical spectrum, however, reaches beyond the boundaries of these two historically defined disease entities. De novo dominant mutations in PMP22, MPZ and EGR2 are known to be a typical cause of very early onset hereditary neuropathies. In addition, mutations in several other dominant and recessive genes for Charcot-Marie-Tooth disease may lead to similar phenotypes. To estimate mutation frequencies and to gain detailed insights into the genetic and phenotypic heterogeneity of early onset hereditary neuropathies, we selected a heterogeneous cohort of 77 unrelated patients who presented with symptoms of peripheral neuropathy within the first year of life. The majority of these patients were isolated in their family. We performed systematic mutation screening by means of direct sequencing of the coding regions of 11 genes: MFN2, PMP22, MPZ, EGR2, GDAP1, NEFL, FGD4, MTMR2, PRX, SBF2 and SH3TC2. In addition, screening for the Charcot-Marie-Tooth type 1A duplication on chromosome 17p11.2-12 was performed. In 35 patients (45%), mutations were identified. Mutations in MPZ, PMP22 and EGR2 were found most frequently in patients presenting with early hypotonia and breathing difficulties. The recessive genes FGD4, PRX, MTMR2, SBF2, SH3TC2 and GDAP1 were mutated in patients presenting with early foot deformities and variable delay in motor milestones after an uneventful neonatal period. Several patients displaying congenital foot deformities but an otherwise normal early development carried the Charcot-Marie-Tooth type 1A duplication. This study clearly illustrates the genetic heterogeneity underlying hereditary neuropathies with infantile onset.Brain 08/2011; 134(Pt 9):2664-76. · 9.92 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Ganglioside-induced differentiation associated-protein 1 (GDAP1) mutations are commonly associated with autosomal recessive Charcot-Marie-Tooth (ARCMT) neuropathy; however, in rare instances, they also lead to autosomal dominant Charcot-Marie-Tooth (ADCMT). We aimed to investigate the frequency of disease-causing heterozygous GDAP1 mutations in ADCMT and their associated phenotype. We performed mutation analysis in a large cohort of ADCMT patients by means of bidirectional sequencing of coding regions and exon-intron boundaries of GDAP1. Intragenic GDAP1 deletions were excluded using an allele quantification assay. We confirmed the pathogenic character of one sequence variant by in vitro experiments assaying mitochondrial morphology and function. In 8 Charcot-Marie-Tooth disease (CMT) families we identified 4 pathogenic heterozygous GDAP1 mutations, 3 of which are novel. Three of the mutations displayed reduced disease penetrance. Disease onset in the affected individuals was variable, ranging from early childhood to adulthood. Disease progression was slow in most patients and overall severity milder than typically seen in autosomal recessive GDAP1 mutations. Electrophysiologic changes are heterogeneous but compatible with axonal neuropathy in the majority of patients. With this study, we broaden the phenotypic and genetic spectrum of autosomal dominant GDAP1-associated neuropathies. We show that patients with dominant GDAP1 mutations may display clear axonal CMT, but may also have only minimal clinical and electrophysiologic abnormalities. We demonstrate that cell-based functional assays can be reliably used to test the pathogenicity of unknown variants. We discuss the implications of phenotypic variability and the reduced penetrance of autosomal dominant GDAP1 mutations for CMT diagnostic testing and counseling.Neurology 08/2011; 77(6):540-8. · 8.25 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: The aim is to review the most relevant findings published during the last year concerning clinical, genetic, pathogenic, and therapeutic advances in motor neuron disease, neuropathies, and neuromuscular junction disorders. Studies on animal and cell models have improved the understanding of how mutated survival motor neuron protein in spinal muscular atrophy governs the pathogenetic processes. New phenotypes of SOD1 mutations have been described. Moreover, animal models enhanced the insight into the pathogenetic background of sporadic and familial amyotrophic lateral sclerosis. Novel treatment options for motor neuron disease have been described in humans and animal models. Considerable progress has been achieved also in elucidating the genetic background of many forms of inherited neuropathies and high clinical and genetic heterogeneity has been demonstrated. Mutations in MuSK and GFTP1 have been shown to cause new types of congenital myasthenic syndromes. A third type of autoantibodies (Lrp4) has been detected to cause myasthenia gravis. Advances in the clinical and genetic characterization of motor neuron diseases, neuropathies, and neuromuscular transmission defects have important implications on the fundamental understanding, diagnosis, and management of these disorders. Identification of crucial steps of the pathogenetic process may provide the basis for the development of novel therapeutic strategies.Current opinion in neurology 08/2011; 24(5):469-74. · 5.43 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: To identify the disease-causing gene responsible for an autosomal dominantly inherited Charcot-Marie-Tooth neuropathy subtype in a family excluded for mutations in the common Charcot-Marie-Tooth genes, we used array-based sequence capture to simultaneously analyse the disease-linked protein coding exome at chromosome 14q32. A missense mutation in fibulin-5, encoding a widely expressed constituent of the extracellular matrix that has an essential role in elastic fibre assembly and has been shown to cause cutis laxa, was detected as the only novel non-synonymous sequence variant within the disease interval. Screening of 112 index probands with unclassified Charcot-Marie-Tooth neuropathies detected two further fibulin-5 missense mutations in two families with Charcot-Marie-Tooth disease and hyperextensible skin. Since fibulin-5 mutations have been described in patients with age-related macular degeneration, an additional 300 probands with exudative age-related macular degeneration were included in this study. Two further fibulin-5 missense mutations were identified in six patients. A mild to severe peripheral neuropathy was detected in the majority of patients with age-related macular degeneration carrying mutations in fibulin-5. This study identifies fibulin-5 as a gene involved in Charcot-Marie-Tooth neuropathies and reveals heterozygous fibulin-5 mutations in 2% of our patients with age-related macular degeneration. Furthermore, it adumbrates a new syndrome by linking concurrent pathologic alterations affecting peripheral nerves, eyes and skin to mutations in the fibulin-5 gene.Brain 06/2011; 134(Pt 6):1839-52. · 9.92 Impact Factor
Publication Stats
2k | Citations | |
755 | Downloads | |
6k | Views | |
597.51 | Total Impact Points | |
Top Journals
- Brain (8)
- Nature Genetics (4)
- Human Mutation (4)
- Neurology (4)
- The American Journal of Human Genetics (4)
Medical University of Vienna
- Department of Orthopaedics
Wien, Vienna, Austria
Medical University of Graz
- • Institute of Human Genetics
- • Center for Medical Research
Gratz, Styria, Austria
Karl-Franzens-Universität Graz
- Section for Neuropsychology
Graz, Styria, Austria
University of Antwerp
- VIB Department of Molecular Genetics
Antwerpen, VLG, Belgium
Landeskrankenhaus Graz
Gratz, Styria, Austria
Medical University of Sofia
- Laboratory of Molecular Pathology
Ulpia Serdica, Sofia-Capital, Bulgaria
Vlaams Instituut voor Biotechnologie
- Genetics and Molecular Techniques
Gand, Flanders, Belgium
Columbia University
- Department of Psychiatry
New York City, NY, United States


text: $1M Settlement For Low-Impact Car Crash – Stress, Trauma Led To Development Of MS By: Michigan Lawyers Weekly Staff in Personal Injury Law, Verdicts & Settlements November 12, 2001 Stress, Trauma Led To Development Of MS Subscribe Login Email Address: Password: Already a paid subscriber but not registered for online access yet? For instructions on how to get premium web access, click here.Forgot your password? Interested in subscribing?Start by choosing how you'dlike your news delivered. Share this:EmailPrintFacebookLinkedInTwitterGoogle +1 1:00 am Mon, November 12, 2001 Michigan Lawyers Weekly Michigan Lawyers Weekly Staff


text:
Strategy and tactics of disarming GHG at the source: N2O reductase crops
Strategy and tactics of disarming GHG at the source: N2O reductase crops
Trends in Biotechnology, Volume 30, Issue 8,
Pages 410-415,
Publication Date 11 May 2012
Copyright © 2012 All rights reserved.
DOI: 10.1016/j.tibtech.2012.04.002
Shen Wan
Tonya Lynn Ward
Illimar Altosaar
Centre for Research on Environmental Microbiology (CREM), Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada, K1H 8M5
Nitrous oxide (N2O), the third most abundant greenhouse gas (GHG), is highly stable and plays a significant role in stratospheric ozone destruction. The primary anthropogenic source of N2O stems from use of nitrogen fertilizers in soil. The bacterial enzyme nitrous oxide reductase (N2OR), naturally found in some soils, is the only known enzyme capable of catalyzing the final step of the denitrification pathway, conversion of N2O to N2. In this opinion, we discuss potential biology-based strategies to reduce N2O by amplifying the amount of available enzyme catalyst in agri-system environments during crop growth and in post-harvest detritus. N2OR from Pseudomonas stutzeri has been tested in transgenic plants with promising results. Such seed-borne phytoremediation systems targeted towards GHGs merit field testing.


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My grandfather was Robert McCager Peeples, son of Alfred H Peeples and Celestia Cincinnati Paschall. A F Peeples b. 1/16/1838, m 9/17/1860, d 12/16/1882. Celestia Cincinnati Paschall b 6/18/1843, d 6/18/1913. 10 children, 9 survived to adulthood. Ella m Will Armstrong, Alfie b 1864, David b 1865, Roxann b 1868, m Lowe, Maggie b 1871, Agnus, b 1874, Lovick b 1876, Don b 1878 and Robert b 12/14/1879, d 7/22/1926. The AH Peeples family is listed in the 1880 census for Obion County, TN dist 16, pahe 114-38. AH was a Pvt in Co K, 31st TN Infantry, CSA. Cincinnati's pension application found on the TN web site. Look under the Obion County listing, #w2515. I have a copy. David D is listed on the 1860 census which lists Ann 46, AH 21, Wiley J 13 and Martha V 9. My grandfather married Hester Mae Brown b 10/29/1873, m 11/15/1905, d 2/7/1968. They had 3 children, Robert Alfred, b 9/23/1906, m Alice K Smith 7/2/1933, d 10/19/1965. Clifton Wallace (my father) b 4/1/1913 m Berdette E (Carpenter) Kohl 3/14/1935, d 9/13/1980, and Agnus Mae b 12/25/1913, married Ronald E Durr 5/29/1941. My aunt is still alive. Are all these people you list in my direct line? Where do you fit into this line?
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CSI: NY alum Eddie Cahill and Misfits vet Karla Crome have joined the cast of Under the Dome for Season 2, according to The Hollywood Reporter.
Cahill will play... Read Full Article
The superhero drama returns for one final outing. As the first anniversary of the storm approaches, the gang discovers a secret Superpower Support Group on the estate. There they meet a mysterious old lady who has the power to knit the future. Strap on your ankle tags, zip up your orange jumpsuit and enjoy the final season of Misfits.
Season 5, Episode 8 Jess is thrown forward in time after she has a one night stand. It's not long before our gang's antics fall short of vigilantes' high moral standards, and battle lines are drawn. Can our gang beat the powerful new group?
Season 5, Episode 7 It's the first anniversary of the Storm. Rudy is totally freaked out by the future sweater Maggie gives to Jess so she ends their relationship. Sally's birthday party gets a little out of hand when Rudy passes out party favors.
Cahill will play... read more
Hello, friends and bannermen. Sunday's Game of Thrones revealed the ruthless sides to a couple of characters we thought we knew well. How did it match up with the books? How did it differ? This weekly chat series is for fans of George R.R. Martin's A Song of Ice and Fire books, upon which HBO's fantasy drama is based... read more
"I think you'll find that there's no such thing as an innocent young offender."
Rudy (Joseph Gilgun) just might be right about the two new delinquents who are serving community service with him when the UK's Misfits kicks off its fourth season on Hulu Monday. The irreverent and violent sci-fi series picks up a short time after the heartbreaking events of last season's finale, in which the group lost star-crossed couple Simon (Iwan Rheon) and Alisha (Antonia Thomas) for good.
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Syracuse Orange Sports
Latest Syracuse University Athletics News, Scores, Analysis, and Opinion
Date Range: March 31, 2006 - March 1, 2006
With 7:43 left in the first...
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the game is scoreless. SU has hit two pipes. Hobart has shot wide of the SU cage... -Donna Full story »
Minutes to game time
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SU is wearing what has become its home attire: white shorts, white shirts. Hobart is wearing orange tops and white shorts. Game tips off in minutes.... -Donna Full story »
Mailbag - More cruising
March 28, 2006, 12:00AM
Cruising with Mac for $2,867.59...Bus cruising with Jeff Kramer to Pulaski for $16.30...Going on poi-patrol with Maureen Green for $4,499... Donnie--Peter Coleman has a gig this year, too: there are about 40 or 50 of us going to Ireland with him in a couple weeks. I like Mac. And, Jeff is a gas. Maureen--well, I don't really know. But,... Full story »
Mailbag - Chiara and lax
March 28, 2006, 12:00AM
Paul Chiara is being modest when he says he "played lacrosse". He was all-state on a Mt. Lakes team that was the public school champions of New Jersey and was that team's faceoff person for both his Junior... Full story »
Pleasant surprises
March 28, 2006, 12:00AM
Greg Robinson last night, what/who has been a pleasant surprise of spring practice: "I feel like, I think the receiving corps is... Full story »
Greg Robinson on ...
March 28, 2006, 12:00AM
Delone Carter (incoming freshman tailback): "Coming from high school to college, there�s a transition. He�ll get an opportunity in fall camp, just like Curtis (Brinkley) did last fall. Curtis, he showed us some things in training camp last year that got our attention. Right now, the focus is on the backs that are here. In training camp, Delone, he�ll... Full story »
A 49er no more?
March 28, 2006, 12:00AM
Full story »
Neumann-Goretti earns ranking
March 28, 2006, 12:00AM
high school boys basketball rankings of the year and Philadelphia's Neumann-Goretti High entered the rankings at No. 24. Syracuse University recruits Antonio Jardine and Rick Jackson are juniors at Neumann-Goretti. The Saints finished with a 22-6 record. The Saints defeated Roman Catholic, 44-41, two weeks ago to win the Philadelphia Catholic... Full story »
March 28, 2006, 12:00AM
Dear Mike, Subjectively, this seems like one of the most exciting basketball tournaments I can remember. Others agree with me. Are there stats on how many buzzer beaters and overtimes there have been this year, compared to other years? Thank you. Peggy Peggy, I checked the... Full story »
New-look Huskies
March 28, 2006, 12:00AM
new names in there. Desmond pretty much writes off Marcus Williams as headed to the pros, while the guy who may or may not be back is center Josh Boone. Mike Waters firstname.lastname@example.com ]]> Full story »
NBA draft stuff
March 28, 2006, 12:00AM
Click here. A few notes: Syracuse's Gerry McNamara is slated to go to Seattle with the 53rd overall pick. Six members of the UConn team that just lost to George Mason figure to go in the draft. The NBADraft.net guys are putting UConn underclassmen Rudy Gay,... Full story »
AP All-Americans
March 28, 2006, 12:00AM
Click here for a look. I think the first team worked out exactly right. I think Rudy Gay got second team based on reputation and not performance. I might've moved Craig Smith from third team to second team. Though not listed, Syracuse's Gerry McNamara was an honorable mention. If I... Full story »
Oh, that dreaded faceoff
March 27, 2006, 12:00AM
I've written so much copy about faceoffs over the years, it seems almost redundant to post any more thoughts about the matter. But given that the faceoff is such an integral part of the game, I keep asking questions and players and coaches keep answering them. Last week, I asked John Desko if his strategy would change this season, seeing... Full story »
Just a reminder...
March 27, 2006, 12:00AM
On Tuesday, John Desko and Matt Kerwick will meet on opposite sides of the restraining box. But this summer, Kerwick (and Albany's Scott Marr) will assist Desko in coaching the U.S. team at the World Games in Ontario. The games will be played July 13-22. And the team will embark on a three-city exhibition tour that starts in Philadelphia on... Full story »
NCAA tickets
March 27, 2006, 12:00AM
Some information for those of you interested in buying tickets for the 2006 NCAA Division I Men's Lacrosse North Quarterfinals. Stony Brook University is hosting the quarterfinals on May 20. Both games at Stony Brook will be televised by ESPNU. General admission bleacher seating throughout the stadium costs $16 and includes 2 games. To order tickets, call 631-632-WOLF or order... Full story »
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Last updated: Wed Mar 12 04:23:51 EDT 2014
CVE Publication rate: 16.8
NVD provides four mailing lists to the public. For information and subscription instructions please visit NVD Mailing Lists
Vulnerability Workload Index: 7.07
Multiple cross-site scripting (XSS) vulnerabilities in the Local Management Interface (LMI) on the IBM Proventia Network Mail Security System (PNMSS) appliance with firmware before 188.8.131.52 allow remote attackers to inject arbitrary web script or HTML via (1) the date1 parameter to pvm_messagestore.php, (2) the userfilter parameter to pvm_user_management.php, (3) the ping parameter to sys_tools.php in a sys_ping.php action, (4) the action parameter to pvm_cert_commaction.php, (5) the action parameter to pvm_cert_serveraction.php, (6) the action parameter to pvm_smtpstore.php, (7) the l parameter to sla/index.php, or (8) unspecified stored data; and allow remote authenticated users to inject arbitrary web script or HTML via (9) saved search filters.
Per: http://www.ventuneac.net/security-advisories/MVSA-10-007 Affected Versions IBM Proventia Network Mail Security System - virtual appliance (firmware 1.6) IBM Proventia Network Mail Security System - virtual appliance (firmware 2.5)
By selecting these links, you will be leaving NIST webspace. We have provided these links to other web sites because they may have information that would be of interest to you. No inferences should be drawn on account of other sites being referenced, or not, from this page. There may be other web sites that are more appropriate for your purpose. NIST does not necessarily endorse the views expressed, or concur with the facts presented on these sites. Further, NIST does not endorse any commercial products that may be mentioned on these sites. Please address comments about this page to email@example.com.
Configuration 1 |
* cpe:/a:ibm:proventia_network_mail_security_system_virtual_appliance |
* cpe:/a:ibm:proventia_network_mail_security_system_virtual_appliance_firmware:1.6 |
* cpe:/a:ibm:proventia_network_mail_security_system_virtual_appliance_firmware:2.5 |


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Was £20.00
Now £6.00
70% Off
Save a total of £14.00
Standard Delivery
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White floral embroidered lace bra
Item No.1500105717
This non padded bra from Gorgeous is styled in white floral lace. It features non padded cups with broderie-style mesh trims and embroidered multi colour flowers across the tops. It is available in sizes D-H.
Also available in this range
- Underwired for support
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- Adjustable straps for a perfect fit
- 77% polyamide, 14% polyester, 9% elastane
Debenhams is happy to exchange or refund your purchase within 28 days providing the goods are in a fully resaleable condition (including tags) and not within the exclusion policy*. This policy does not affect your statutory rights. You can return unwanted items either by visiting your local store (the fastest way to get a refund), by arranging a courier collection or returning by post. Exclusions apply to selected products. For instructions on how to return products and information on Debenhams refund policy visit the returns and refunds section of the website.


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Where Calgary Comes for Ford
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We carry all makes in used inventory, not just Ford. We can help find something for your lifestyle. Our selection is vast. Flexible finance options are also available for pre-owned vehicles.
Woodridge Tire Store
The Woodridge Tire Store has an unparalleled number of in-stock tires (and rims?) for nearly every make and model of vehicle. Great customer service, a full range of brands and no hassle purchase and install – just a few reasons why our customers keep coming back. Call one of our qualified Service Advisors for details.
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Jennifer L Hewitt
Full Name: Jennifer Love Hewitt Birth Date: 21 February 1979, Location: Waco, Texas, USA Nickname: Love Height: 5' 3" Hair Colour: Auburn Eye Colour: Brown Family: mom; Pat Hewitt, dad;Tom Hewitt, brother; Todd Hewitt Weight: 117 lb Education: Laurel Springs High School, Ojai, CA (1997)
Hewitt got her first name from her older brother Todd (b. 1971), who picked then name for a little blonde girl he had a crush on. Her mother selected her middle name, Love, which she goes by offstage from her best friend at college. Her mother, Pat, is a speech pathologist and her father, Danny, is a medical technician article continued below....
AskMen.com: Jennifer Love Hewitt TeraBabes: Jennifer Love Hewitt Freeones.com - Jennifer Love Hewitt Babemania.com - Jennifer Love Hewitt
Her parents separated when she was six months old. Born in Waco, Texas, she was raised by her mother in Killeen. She made her official performing debut at age 3 where she sang at a livestock show. At age 5, she was taking tap, jazz, and ballet lessons which led her to joining the Texas Show Team, which toured the Soviet Union and Europe. At age 10, the family moved to L.A. with the encouragement of talent scouts, while Todd stayed behind to finish high school in Texas. Love quickly found commercial work and a role on Disney's "Kids Incorporated". She went through a series of television flops before finally hitting it big on "Party Of Five" in 1995.
Jennifer Love Hewitt C/O Party of Five FOX Broadcasting Company 10201 W.Pico Blvd Los Angeles, CA 90035


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The actress was the guest of honour at the dance company's Black & White Ball in Las Vegas on Saturday (28Jan12), where she was recognised by bosses for her philanthropy and "dedication to the world of arts and entertainment".
She took to her Twitter.com page on the morning of the event to tell fans about her latest trophy, writing, "Off to Vegas to attend the Nevada Ballet Black & White Ball. Thank you for honoring my work!"
Past recipients of the Nevada Ballet Theatre's prize include Debbie Reynolds, Marie Osmond, Priscilla Presley, Celine Dion and Bette Midler.


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Snow Watch
Julian Dawson
Julian Dawson
Original Release Date: March 23, 1999
Track Listing
1. I Like Your Absence
2. Luckiest Man in the Western World
3. How Can I Sleep Without You
4. No Place Worth Dying For
5. Fragile as China
6. Cold Cold World
7. Two Shots of Jealousy
8. Always There
9. We've Been Through the Fire
10. I Don't Feel Like Dancing
11. When Love Says Goodnight
12. As Real as Disneyland
13. Spark of Human Kindness
14. Spark [Instrumental]
Julian Dawson: Guitar (Acoustic), Harmonica, Percussion, Composer, Guitar (Electric), Vocals
Alistair Anderson: Northumbrian Smallpipes
Jo-El Sonnier: Accordion
Steve Forbert: Vocals (Background)
The Roches: Vocal Harmony
Richard Thompson: Guitar
Lucinda Williams: Vocal Ad-Libs
Greg Trooper: Vocals (Background)
Dan Penn: Vocal Harmony
P.P. Arnold: Vocal Harmony
Barry Beckett: Organ (Hammond)
Larry Campbell: Guitar, Violin
Gerry Conway: Drums
Rosko Gee: Bass
Mark Griffiths: Bass
Lynda Hayes: Vocal Harmony
Zev Katz: Drums
Stevie Lange: Vocal Harmony
Mike Lawler: Keyboards
Stewart Lerman: Producer
Dennis Locorriere: Vocals (Background), Vocal Harmony
Kimberley Rew: Guitar
Vince Santoro: Drums, Vocals (Background)
Steuart Smith: Guitar
Garry Tallent: Bass, Producer
Rene Tinner: Producer
Jumpy Zerlett: Keyboards, Producer
Raoul Walton: Bass
Jay Stapley: Guitar
Jaki Liebezeit: Percussion, Drums
Karl Maria Hofer: Photography
Trevor Leighton: Photography
Lydie Auvray: Accordion
Andreas Wittig: Cover Art Concept, Credits Director
Mike Nobel: Guitar (Acoustic)
Kenneth Blevins: Drums
Bertram Bahner: Photography


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I'm graduated in 2011 as a painter and a visual art teacher at Hungarian University of Fine Arts, Budapest. At he moment I'm one of the two vice principal of an oldest Hungarian Seconrady School of Visual Arts (founded by Maria Theresa in 1778).
As an artist I'm very appreciante the
Redfield is inspired by the natural world at its quirkiest, and flirts with magical realism. Moving back to America and settling in the Hudson valley after twenty years in Europe she has turned her creativity back to painting and Illustrating after a prolonged hiatus in which she worked overseas i
John Kameel Farah is a Toronto-based pianist, composer, electronic musician and artist. Having studied composition and piano performance at the University of Toronto, (wh
Paul Erdös was one of the most eminent mathematicians of the twentieth century, as famed for his prolific output and outsize capacity for abstract mathematic comprehension as he was for his incurable wanderlust and distaste for sleep. His extraordinary productivity, preference for colla


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March 5 (Bloomberg) -- Bloomberg Industries analyst Kapilan Pillai examines results from Standard Chartered Plc as the company posted its 10th consecutive year of record profit as increased corporate-banking revenue. He speaks on Bloomberg Television's "The Pulse."
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With Instructables you can share what you make with the world and tap into an ever-growing community of creative experts.
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this rubber band powered plane is made out of flat tooth picks, a lego propelor, and a knex gear. it can fly about 20 ft.
the thing you will need to make this will be flat tooth picks, cearal box card board, hot glue, lego propeller, lego conector see pix below , paper cl...
get the paper clip and turn it into a hook shape at the end. then with the other end bend it back and forth intell it breaks. then bend the tip back i...
put the conector/hook into the gear.donot glue it. then put the rubber band into the hook close the hook with plyers. then cut 1 1/2 in propeller shap...
cut 8 in of the card board then glue it to the frame, fold the index card into fourths then cut 1 fourth then fold it in half, glue 4 or 5 1/2 tooth p...
to throw it you turn the propeller clock wise then hold the propeller with a finger. there are different ways to throw it some will work better than o...
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Often appearing on small labels with distribution problems, Lisa Germano hasn't had as much luck as a solo artist as she has as a first-call fiddling side person. Her forthcoming release No Elephants makes the case for seeking her out again.
Here's a sample of this terrific new project, an exclusive stream of "… And So On" courtesy of Badman Recording Co., which is due on February 12, 2013.
Germano, if you haven't discovered her yet, made important contributions to hit albums like 1987′s The Lonesome Jubilee and 1989′s Big Daddy, both by John Mellencamp; 1990′s Nomads Indians Saints by the Indigo Girls and The Globe Sessions by Sheryl Crow, while working with Iggy Pop, Crowded House's Neil Finn, David Bowie and Jewel along the way.
[SOMETHING ELSE! REWIND: Lisa Germano's dimly lit 'Happiness' didn't sound anything like her days with John Mellencamp. Instead, it was enigmatic, tough and then tender, a wonder of small epiphanies.]
She started a tandem solo career with 1991′s self-released On the Way Down From the Moon Palace, and the lo-fi effort helped Germano to a brief stay with Capitol Records — which released the superlative Happiness in 1993. The follow up, 1994′s Geek the Girl, was named one of the top albums of the decade by Spin.
Germano added a song to the 1995 compilation Red Hot + Bothered, and produced the full-length Excerpts from a Love Circus in 1996, having switched to the Warner-distributed 4AD. By the time Germano released the Tchad Blake-helmed Slide, however, 4AD had gone independent again. Germano toured with the Smashing Pumpkins in support of their project Adore, and subsequently worked with Bowie and Finn.
Germano wouldn't return in earnest to her solo career until 2002, but since she's been on a creative tear. Lullaby for Liquid Pig, featuring Johnny Marr (The Smiths, Modest Mouse), Finn and Wendy Melvoin, followed — though that album's label home also subsequently shuttered. Germano then switched to Young God Records, run by Michael Gira (Swans), and issued In the Maybe World and Magic World, her two most recent efforts.
Something Else!
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- 'Is this really Queen without Freddie?': Brian May defends tour with Adam Lambert - March 9, 2014
- 'We just love playing together': Paul McCartney's current band has outlasted the Beatles, Wings - March 9, 2014
- 'It was hard to keep myself focused': Tom Scholz wondered if he'd ever finish Boston's Life Love and Hope - March 8, 2014


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Client Side Testing
From OWASP
This article is part of the OWASP Testing Guide v4 (the current status is:DRAFT).
OWASP Testing Guide v4 Table of Contents [DRAFT] At the moment the The entire OWASP Testing Guide v3 can be downloaded here.
4.15 Client-Side Testing
Client-Side Testing
The following articles describe details on how to conduct a Client-Side test of a web application:
4.15.1 Testing for DOM based Cross Site Scripting (OTG-CLIENT-001)
4.15.2 Testing for JavaScript Execution (OWASP-CS-002)
4.15.3 Testing for HTML Injection (OWASP-CS-003)
4.15.4 Testing for Client Side URL Redirect (OWASP-CS-004)
4.15.5 Testing for CSS Injection (OWASP-CS-005)
4.15.6 Testing for Client Side Resource Manipulation (OWASP-CS-006)
4.15.7 Test Cross Origin Resource Sharing (OTG-CLIENT-007)
4.15.8 Testing for Cross Site Flashing (OTG-CLIENT-008)
4.15.9 Testing for Clickjacking (OTG-CLIENT-009)
4.15.10 Testing WebSockets (OTG-CLIENT-010)


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Silver Springs Villa Falmouth
Official Contact Details - Silver Springs
Phone: +44 1326 341190 Fax: +44 1326 341190A modern 5 bedroom house with heated swimming pool in 5 acres of beautiful Cornish countryside. Private gardens with secluded courtyards,streams and lake.Secure parking. Close beaches,river,towns,pubs
- Price from 142 GBP / Day
- Capacity up to 9 people
- 5 bedrooms & 3 bathrooms
(click on a photo to view it)
Last updated: 06/24/2009
This is your property ?
Our beautiful home is in private grounds and wonderful gardens with streams and a Koi lake.The privacy affords Au Natural sunbathing should you wish and a splendid hot tub in a private building. Close to the Cornish coastline and the beautiful Helford River.
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Set in open countryside in farmland close to local village and riverside pub/restaurants.The fishing village of Porthleven is a short drive as is the port of Falmouth.
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- Lower Trec, Constantine, Tr11 5QW, Falmouth, Cornwall, England, United Kingdom
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- coastal, countryside, leisure area, near cultural interest, near diving spot, near fishing area, near golf course, near historical interest, near horse riding, near restaurants & bars, near shopping area, near the beach, near water sports, rural, village!
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Large private gardens for secluded sunbathing. Plenty of secure parking.
# of Units: 1... and each unit includes:
- Bedrooms: 5
- Bathrooms: 3
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- Sea View:
- Central Heating:
Review - Silver Springs
Silver Springs - Contact the owner
Important Notice : Avoiding Fraud
It's rare, but some helpful hints to watch out for with regards to fraud:
- It is important to NEVER wire funds or use/employ other fund transfer mechanisms such as western union: Always use a credit card to protect yourself against fraud. If owners pressure you into providing a deposit or refuse to accept credit cards, there is a high probability that this is a scam.
- If at all suspicious of fraud, ask to see their website, or any other literature they can provide or send to you. Ask them for contact details for guests who have previously stayed on their property insisting on telephone numbers. Be suspicious of emails that originate from free email services (yahoo, hotmail, gmail, etc)
- Research the property thoroughly on the internet to see if there is any history or mention of scams associated with the property.


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Rosie Napravnik (Admiral Kitten, 1st): "We were able to sit back and realx, that's kind of the horse's style. We got a clear trip around the second turn and he was just finishing fat.
In Today's Notes: Dark Cove out of American St. LegerFour Jockeys Can Win Festival's Three Grade I StakesQuartet of Riders Can Win Another Million
In Today's Notes: Well Traveled Side Glance Ready for More; Fourth Time Hopefully a Charm for Wigmore Hall; Noseda Sanguine and Sensible
In Today's Notes: Little Mike Connections Hope Million Sets Up Showdown with Wise Dan
In Today's Notes: Two Euros Put in Grass Works for Festival; Gifted Girl Camp Confident; "Little Difference" between Botti's Dandino and Jakkalberry
In Today's Notes: $1 Million Purse Attracts Indy Point to Arlington Million
In Today's Notes:The Apache Works Toward Million;Dank a Danger to the Favorites in the Beverly D.
ARLINGTON HEIGHTS, Ill. (August 14, 2013) – Priscilla Vaccarezza's three-time North American Grade I winner and defending Arlington Million champion Little Mike will defend his crown against a field that includes the winners of Group I races on four other continents in Saturday's marquee turf spectacular. The Dale Romans-trained son of Spanish Steps has not finished better than fourth in three Grade/Group I events in 2013, including a disappointing trip to Dubai, but has been training forwardly for his confident connections.
ARLINGTON HEIGHTS, Ill. (August 14, 2013) – Craig Bernick said he wants to test his family's Marketing Mix on an international level, and the mare will get that chance as the 5-2 morning line favorite against eight others in the Grade I $750,000 Beverly D. Stakes as part of the International Festival of Racing on Saturday at Arlington International Racecourse.


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Butternut Squash Ravioli with Sage Butter Sauce
Butternut squash, crushed gingersnaps, and aged Parmesan become an incredible filling for tender ravioli that make an elegant seated appetizer.
Yield: 8 servings
More From Oxmoor House
- 1/2 cup crushed gingersnaps (about 8 cookies)
- 2 tablespoons milk
- 1 (2-pound) butternut squash
- 1 cup (4 ounces) freshly grated Parmigiano-Reggiano cheese, divided
- 2 tablespoons butter, softened
- 1/2 teaspoon salt
- 1 (12-ounce) package won ton wrappers
- Sage Butter Sauce
- Freshly ground pepper
- Stir together gingersnaps and milk in a medium bowl. Let stand until cookies are softened (about 10 minutes).
- Cut squash in half lengthwise; remove seeds. Line a baking sheet with aluminum foil. Coat foil with cooking spray. Place squash, cut side down, on foil. Bake, uncovered, at 400° for 30 to 40 minutes or until tender. Scoop out pulp; mash. Discard shell. Measure 1 3/4 cups pulp; reserve any remaining pulp for another use.
- Stir 1 3/4 cups squash pulp, 1/2 cup cheese, butter, and salt into softened gingersnaps. Working with 6 won ton wrappers at a time (keeping remaining wrappers covered), spoon about 1 tablespoon squash filling into center of each wrapper. Moisten edges of each wrapper with water; bring 2 opposite corners together. Press edges together with a fork to seal, forming a triangle. Cover ravioli with a damp towel to keep them from drying.
- Bring 2 quarts water to a boil in a large saucepan. Cook ravioli, 6 at a time, uncovered, 1 to 2 minutes. Quickly remove from water with a slotted spoon. Keep warm. Place 6 ravioli in each serving bowl. Top each with 1 tablespoon Sage Butter Sauce. Sprinkle evenly with remaining 1/2 cup cheese and pepper.
Butternut Squash Ravioli with Sage Butter Sauce Recipe at a Glance
- COURSE: Appetizers, Hors d'Oeuvres
- CONVENIENCE: Entertaining
- MAIN INGREDIENT: Vegetables, Pasta
- PUBLICATION: Oxmoor House
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05-07-2010 12:08 PM - edited 05-07-2010 12:14 PM
I got a Zales Credit Card back in 1998. Currently it is my oldest card. For years I thought the account had been closed since Jewelers National bank had closed. My CR's show this account as open with a $1200 limit, $0 balance. Do I mess with this or should I just leave it? The $1200 limit really helps with my utilzation numbers and this is a card in good standing and again, my oldest card, so my AAoA could take a hit if I do anything regarding this card that could have it removed from my CR's. The card hasn't been used in 10 years. I tried to look up my account on the Zales website and it wasn't found so I can't use this card. Not sure what to do about this.
If its only doing good, then leave it. I have a card with WFFNB that is my oldest card and has a 0 balance, and decent credit line. I closed it years ago but since its my oldest card and has no balance I dont touch it. Keeps my AAoA high.
myFICO is the consumer division of FICO. Since its introduction 20 years ago, the FICO® Score has become a global standard for measuring credit risk in the banking, mortgage, credit card, auto and retail industries. 90 of the top 100 largest U.S. financial institutions use the FICO Score to make consumer credit decisions.
>> About myFICO


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Video: Top News
Residents of Central African Republic await transitional government to restore peace (1:23)
Jan. 11 - Residents of the capital of Central African Republic hope a new transitional government will bring peace after months of inter-religious violence. Mana Rabiee reports. ( Transcript )
Reuters TV Shows
About Reuters TV
Hard-edged reporting, insight and analysis, Reuters TV breaks ground creating informative news and financial videos. Showcasing Reuters' 3000 award-winning journalists, Reuters TV delivers high-energy investigative journalism with concise explanations. Check it out and let us know what you think.


text: You already know about the superspeedy stir-fry, but curried peanut noodles are another quick Chinese meal you can throw together faster than most restaurants can deliver. Mung bean sprouts and carrot add plenty of crunch, and you can also add water chestnuts and chopped red peppers. Red curry paste adds a nice kick. If you prefer spicier, use green; milder, use yellow. Get the recipe: Red Curry Peanut Noodles |


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Is there anyting specific you need to know to work at a Macys makeup counter?
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Is there anyting specific you need to know to work at a Macys makeup counter?I have an interview next week and I have never worked in retail before I have been told there isn't much to it except for sales which i don't think i would have a hard time with. If there is any advice any one would like to give it would be highly appreciated!!
Asked By: Julianna - 11/6/2010
Best Answer - Chosen by Asker
Retail experience would probably be preferred, and a knowledge of makeup products would be essential. You have to know what you're selling, so that the customer can ask you questions, and so that you can ultimately make more sales...
Answered By: Sam Doggy Dog - 11/6/2010
Additional Answers (1)
cosmetics background is a plus!
personality and great customer service!
Answered By: lucywuzzy - 11/7/2010
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Kristy Button Down Top
Size Guide
- 75% Rayon, 25% Nylon
- Made in the U.S.A.
- Color: Black, White
- 27" long
Note: Lining not included. Line dry.
Measured on a size Small. Runs true to size.
Arielle is wearing a size Small in Black.
Arielle 's profile: height 5' 10", bust 32", waist 23", hips 33"
Kiersten is wearing a size Small in White.
Kiersten's profile: height 5'10", bust 34", waist 25", hips 36"
Arielle is also wearing (in Black):
Rachel is also wearing (in White):


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DescriptionA great route with a great rest straddling the arete that earned this unique route its name. LocationThis route is immediately right of the "Trash Compactor" a large, rectangular rockhouse with a slab at the back and a huge roof above. The arete to the right of the inset bears a route on its right side "Reserved Seating." Protection6 bolts to a bolted anchor.


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However, they are also the adult generation most closely associated with our current education system. Other surveys have shown that college tends to make students more liberal (or less informed, which is pretty much the same thing). Many of them will grow out of it as they pay taxes, get mugged, try to start a business (or keep one going) or otherwise interact with the real world. As Ronald Reagan said, the facts of life are conservative.
It was Winston Churchill who said that if you are not a socialist before you are thirty, you have no heart, but that if you are still one after thirty, you have no brain.
There's a conversion formula:
A liberal who gets mugged becomes a conservative.
A liberal who gets his first tax bill becomes a libertarian.
A conservative who gets elected and stays in office long enough becomes a liberal.
A conservative who wants to have a threesome becomes a libertarian.
A libertarian who gets mugged becomes a survivalist.
A libertarian who has a teenage daughter becomes a social conservative.
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Dr. Barton Gee Williams MD
Is this you? Claim profile
Dr. Barton Gee Williams MD is a male Emergency Medicine Specialist, has 21 years of experience and practices in Family Medicine, Emergency Medical Services, and Diagnostic Radiology.
Wrightsville Family Practice
1414 S 39th St
Wilmington, NC 28403
Phone Number
Locations and availability (1)
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. Barton Williams:
View the full profile to get information on:
- Qualifications
- What's important to you
View full profile
Patient Reviews
The overall average patient rating of Dr. Barton Williams is Good.
Patient Ratings | |
Ease of Appointment |
Promptness |
Courteous Staff |
Accurate Diagnosis |
Bedside Manner |
Spends Time with Me |
Follows Up After Visit |
Specialties & Research
Dr. Barton Williams, MD is board certified in Family Medicine.
More Specialties & Research
Education & Awards
Dr. Williams graduated from University of North Carolina, Chapel Hill.
More Education & AwardsAffiliations
Dr. Williams has 3 hospital affiliations:
- New Hanover Regional M.C.
- Pender Memorial Hospital
- Cape Fear Hospital
More Affiliations
Accepted Insurance Plans
Dr. Williams accepts these health insurances in at least one office:
- United Healthcare - 15 plans
- Blue Cross Blue Shield of North Carolina - 13 plans
- Great-West Healthcare - 2 plans
- ODS Health Plans - 1 plan
- Humana - 8 plans
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- Where does Dr. Barton G. Williams practice?
Dr. Barton Williams practices Family Medicine, Emergency Medical Services, and Diagnostic Radiology near Wilmington, NC.
See Wilmington Family Physicians, Wilmington Emergency Physicians, and Wilmington Radiologists.


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Stanton, North Dakota |
For population 25 years and over in Stanton:
For population 15 years and over in Stanton city:
1 residents are foreign born
Median real estate property taxes paid for housing units with mortgages in 2011: $700 (1.2%) Nearest city with pop. 50,000+: Bismarck, ND (45.1 miles , pop. 55,532). Nearest city with pop. 200,000+: Minneapolis, MN (421.3 miles , pop. 382,618). Nearest city with pop. 1,000,000+: Chicago, IL (772.6 miles , pop. 2,896,016). Nearest cities: Hazen, ND (3.4 miles ), Riverdale, ND (3.5 miles ), Pick City, ND (3.7 miles) , Center, ND (3.8 miles ), Underwood, ND (3.8 miles ), Washburn, ND (4.1 miles ), Coleharbor, ND (4.1 miles) , Beulah, ND (4.3 miles ). Single-family new house construction building permits:
Latitude: 47.32 N, Longitude: 101.38 W Area code: 701 Unemployment in July 2013:
Unemployment by year (%) Population change in the 1990s: -171 (-33.1%).
Work and jobs in Stanton: detailed stats about occupations, industries, unemployment, workers, commute |
Average climate in Stanton, North DakotaBased on data reported by over 4,000 weather stations
Tornado activity:Stanton-area historical tornado activity is slightly above North Dakota state average. It is 27% smaller than the overall U.S. average. On 6/18/1956, a category F3 (max. wind speeds 158-206 mph) tornado 8.8 miles away from the Stanton city center injured one person and caused between $50,000 and $500,000 in damages. On 6/5/1956, a category F3 tornado 19.9 miles away from the city center caused between $5000 and $50,000 in damages. Natural disasters:The number of natural disasters in Mercer County (19) is greater than the US average (12).Major Disasters (Presidential) Declared: 15 Emergencies Declared: 4 Causes of natural disasters: Floods: 8, Storms: 8, Snows: 4, Floods: 4, Winter Storms: 4, Blizzard: 1, Landslide: 1, Mudslide: 1, Tornado: 1, Drought: 1, Hurricane: 1, Snow: 1 (Note: Some incidents may be assigned to more than one category). Political contributions by individuals in Stanton, ND Colleges/universities with over 2000 students nearest to Stanton:
Public high school in Stanton:
Public elementary/middle schools in Stanton:
(lower is better) Air Quality Index (AQI)
Drinking water stations with addresses in Stanton and their reported violations in the past:STANTON CITY OF (Population served: 345, Groundwater):Past health violations:GREAT RIVER ENERGY - STANTON STATION (Address: 4001 HIGHWAY 200A , Population served: 75, Groundwater): Past health violations: Percentage of residents living in poverty in 2011: 8.8% (9.5% for White Non-Hispanic residents, 0.0% for Hispanic or Latino residents, 0.0% for American Indian residents, 0.0% for two or more races residents) Average household size:
Percentage of family households:
Percentage of households with unmarried partners:
Likely homosexual households (counted as self-reported same-sex unmarried-partner households)
Detailed information about poverty and poor residents in Stanton, ND 6 people in local jails and other municipal confinement facilities in 20106 people in local jails and other confinement facilities (including police lockups) in 2000 Stanton compared to North Dakota state average:
Banks with branches in Stanton (2011 data):
Most commonly used house heating fuel:
2000 Presidential Elections Results 2004 Presidential Elections Results 2008 Presidential Elections Results 2012 Presidential Elections Results Graphs represent county-level data. Detailed 2008 Election Results Religion statistics for Stanton (based on Mercer County data)Percentage of population affiliated with a religious congregations: 95.59%
Adherents Breakdown of population affiliated with a religious congregations
Tables represent county-level data. Food Environment Statistics:Number of grocery stores: 3
Number of convenience stores (with gas): 8
Number of full-service restaurants: 10
Adult diabetes rate:
Adult obesity rate:
5.18% of this county's 2006 resident taxpayers lived in other counties in 2005 ($44,857 average adjusted gross income)
10 or fewer of this county's residents moved from foreign countries between 2005 and 2006. Top counties from which taxpayers relocated into this county between 2005 and 2006:
7.52% of this county's 2005 resident taxpayers moved to other counties in 2006 ($35,316 average adjusted gross income)
10 or fewer of this county's residents moved to foreign countries between 2005 and 2006. Top counties to which taxpayers relocated from this county between 2005 and 2006:
Strongest AM radio stations in Stanton:
Strongest FM radio stations in Stanton:
FCC Registered Antenna Towers:6
FCC Registered Private Land Mobile Towers:6
FCC Registered Microwave Towers:2
2006 National Fire Incident Reporting System Incidents:
Back to Stanton, ND housing info, Mercer County, North Dakota, ND smaller cities, ND small cities, All Cities.


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Took the new camera up Waddamanna Dam Musuem, it's remote, where they have the beautiful machinery of the old Dam,mostly from Britian and the U.S and not doubt carted by bullock. This is the huge pelton turbine, a big water wheel.I used the natural light from the huge windows.
Brand: | OLYMPUS IMAGING CORP. |
Camera: | Olympus E-620 Check out Olympus Image Space! |
Lens: | ZUIKO DIGITAL ED 14-42mm 1:3.5-5.6 |
Recording media: | JPEG (digital) |
Date Taken: | 22 Jun 2012 - 11:07 AM |
Focal Length: | 42mm |
Lens Max Aperture: | f/3.5 |
Aperture: | f/5.6 |
Shutter Speed: | 1/80sec |
Exposure Comp: | 0.0 |
Exposure Mode: | Creative (Slow speed) |
Metering Mode: | ESP |
Flash: | Auto, Did not fire |
Title: | Pelton Turbine |
Username: | abeeror2 |
Uploaded: | 13 Jul 2012 - 5:20 AM |
Tags: | Black & white, General |
VS Mode Rating |
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No Text
more product information
Recommend: Yes
The card look very expensive before I bought my cards at the dollar store before. which meant looking and looking for the right card for the right person ,now i sit in the comfort of my own home and the cards are less expensive and meaningful
Got these to give out to my choir - nice cards!
Great cards, they really express the sentiments you're trying to convey.
Very nice cards. I have been giving a number of boxes as gifts. They're really appreciated.
These are absolutely beautiful cards!
A Sunday Scripture
Praise the Lord. How good it is to sing praises to our God, how pleasant and fitting to praise him! The Lord builds up Jerusalem; he gathers the exiles of Israel. He heals the brokenhearted and binds up their wounds. He determines the number of the stars and calls them each by name. Great is […]
You Can Be Certain… Part 2 of 2
God has His eye upon you and you are precious to Him and loved. Since you were precious in My sight, You have been honored, And I have loved you; […]


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The Old Fountain (London) Reviews
Description:3 Baldwin Street, London, EC1V 9NU. Tel: 020 7253 2970.
Newest Review: ... supplied by the brewer. Over time breweries bought up public houses that came onto the market. More insidiously, they also supplied loans to landlords, the loans coming tied to an obligation to take only the brewery's beers. So, "Free Houses" became "Tied Houses". Sadly, many landlords didn't have the honesty to remove the "Free House" sign from ... more
Customer The Old Fountain (London) Reviews (1)
by - written on 27/02/02, updated on 27/02/02 (Very useful, 105 readings)
The Old Fountain 3 Baldwin Street London, EC1V 9NU 020 7253 2970 I've been up and down the City Road many times but I've never been in or out of The Eagle. Don't get me wrong, I have nothing against The Eagle, it's just that it's a bit far from the part of the City Road that I usually get to. As far as I know it's a quite reasonable pub. Probably trades very much on its nursery rhyme association but then you'd expect that wouldn't you? No, I usually end up at the Old Street end. That's the part of the City Road where you find the world-famous Moorfields Eye Hospital. Actually, that's not the ... Read the complete review
Products Similar to The Old Fountain (London)
Dove (London) - Riverside location and atmosphere Difficulty in getting a seat on the terrace
Vesbar (London) - Laid back stylish bar with nice nosh Can't think of any!
Zero Degrees (London) - the beer and pizzas cocktals and wine more expensive, very busy
The Vibe Bar - Good for people watching Not close to my house
Lamb and Flag (London) - oldest pub in covent garden (& maybe london) the outside space is not so good!
More products in Pub / Bar National All these and are taken from reviews of the dooyooCommunity. | ||
Pubs/Bars in London Central (South West) in general great food, good selection of drinks, nice beer garden a bit dark inside the main bar | Pubs/Bars in London East in general Good atmosphere, good layout Pants location | Pubs/Bars in London South in general beer garden/food staff |
Pubs/Bars in London North in general Nice, not as expensive as other pubs in Hampstead Gets crowded on Friday & Saturday nights | Pubs/Bars in London West in general atmosphere, decoration, function room food | Pubs / Bars in York in general plenty to choose from too many to choose from |
Pubs / Bars in Birmingham in general Huge choice; Cheap food and drinks; Good policing Taxi drivers try to rip you off; | Pubs in Berkshire in general There are plenty of parking spaces Rather cramped and smoky | Pubs in Cambridgeshire in general Choice (13?), A pub for every taste; disco, indy, house, no music at all, Good prices, familiar faces Staff get to know you and you feel ashamed |
Pubs in Cumbria in general good food, good beer, good service no views. |


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Hotels and Andalucia Tourism, News, Expat Guide
When a young woman in England wins a weekend away with her boyfriend to Ronda, things start to get a little crazy. She speaks some Spanish, and he speaks none - with hilarious results as she delights in causing him further embarrassment. Especially when he sprains his ankle in the gorge.
Emily's Ronda Romance is a romantic tour of Ronda, Setenil de las Bodegas, Acinipo, Grazalema, and Zahara de la Sierra. What Emily really wants is an engagement ring. Will she get it? Read more.
For shoe repair, clothing alterations, key cutting, replacement garage and security gate remotes, leather bags and suitcases, see Tony Zapatero in c/ Sevilla
» Read the Full ArticleA delightful, easy going walk to the beautiful Tajo del Abanico, where the bandit scenes from Bizet's Carmen were filmed, though the area is better known for its wildflowers
» Read the Full ArticleIcon of the Serranía de Ronda, and a fearsome bird of prey, Bonelli's Eagle is described by Peter Jones of Spanish Nature, a local tour guide with amphasis on birdwatching
» Read the Full ArticleA day trip from Ronda to Fuente de Piedra with the Andalucia Bird Society to see greater flamingo and other birds
» Read the Full ArticleAn exceptional four star hotel catering to people of taste who demand comfort and style, and prefer a room with character. El Poeta de Ronda only provides hand-made furniture, and is centrally located. From €50
» Read the Full Article» View at Booking.comA gentle walk of around 2 hours from the industrial area of Ronda into a lovely countryside road with lots of stables and then finishing in a pine forest close to the city
» Read the Full ArticleRumours suggest Ronda may get a foreigners office, but what would it do, and what would you like it to do?
» Read the Full ArticleA delightful luxury hotel in Cartajima, a small village in the Genal Valley, perfectly located for trekking from village to village. From €95
» Read the Full Article» View at Booking.comInterview with Sarah Spencer, owner of Gemini Courses about intensive English courses abroad in Dublin, New York, London, Canada etc
» Read the Full ArticleAn attractive, affordable, and exclusive country retreat near Gaucin away from the major tourist tracks, yet deceptively close enough that day trips are a pleasure and easily undertaken. From €62
» Read the Full Article» View at Booking.comAn excellent resource for the nature lover who enjoys trails through the bio-diversity of western Andalucía. The Crossbill Foundation have done an excellent job of introducing the wonder of Malaga and Cadiz provinces to the nature lover.
When Emily wins a Valentine weekend in Ronda, she has no idea how much Spain can change a person in just two days. She's about to find out. This is a sweet romantic comedy, with Ronda and the White Villages as backdrop.
We're delighted to review an expat romp set in Andalucía, "Seriouly Mum, What's an Alpaca?" by Alan Parks. Giving up a life as a dance teacher for Lorna, Alan's better half, seemed to have been an easy decision. [Get from Amazon UK: Seriously Mum, What's an Alpaca? - An Adventure in the Frying Pan of […]
Kate Nicol's Divulgence takes us through the split lives of British expat Grace Marchant as she struggles to reconcile her conscience after committing adultery. An absorbing read.
A review of Loosely Translated, a funny romance between an uncultured English writer, and his Spanish translator – who rewrote his book completely.
A complete expert checked list of birds endemic to the Serrania de Ronda, and those that follow migratory paths between Northern Europe and Africa. With a list of special interest sites to view birds of Ronda.
Fantastically funny book about life in a small village of the Alpujarras in Almería province. This is the real Spain as experienced by inexperienced English expats who really believed retired life in the Spanish countryside would be perfect.


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Bucks County Community Swaps Gift Cards For Firearms
By Brad Segall
BRISTOL TOWNSHIP, Pa (CBS) — On the heels of a successful gun buyback program three years ago, a Bucks County community is again offering supermarket gift cards in exchange for firearms.
Bristol Township is using $25,000 in casino grant revenue to try to make the streets of the community safer. Every Tuesday and Thursday until the funds are exhausted — people with unwanted guns can bring them to the township administration building and receive a gift card.
Police Chief James McAndrew says it's way to reduce crime and gun violence.
"We have had some homicides," he says. "We have had guns pulled on our officers, we've had to call out our SWAT team on occasion."
Police will give $50 for a rifle, $75 dollars for a handgun and $100 for an automatic or semi-automatic weapon.
"To get a rifle off the street is less important than to get a revolver," McAndrew says. "Because a revolver or a handgun can be easily hidden and concealed on the body."
Police will accept the guns anonymously, no questions asked. Last time, the program took nearly 300 guns off the streets.
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Jared G. Turner: Executive Vice Chairman
Mr. Turner has a ten-year track record of recognizing specialty retail franchise opportunities and growing the concepts from small startup companies into professionally organized enterprises. Founded YaketyYak Wireless, which at its peak was the fastest growing wireless franchise retail chain in the United States. Parlayed the YaketyYak franchising experience to grow Play N Trade from 10 retail locations to 250 locations in three years. Founded, funded and launched an international network security company that merged with a Swedish organization in 2006 and is franchised in over 30 countries. Still active as a Director of the firm.
Charles Beaupre: CEO
Charles has over 17 years of experience in the world of video gaming. He built the largest video game franchise network in Canada, DimensionGames. He is also the founder of SE2, a technology company that contributed to the success of his video game franchise. His understanding of the industry and the technology it takes to be successful makes him an expert in this exciting industry.
Charles merged his stores with Play N trade in 2012 and has taken over as CEO of the new, larger franchise operation. Charles' passionate leadership is contagious and he is a leader in the world of franchising. In advocating the benefits of franchises, he remarks that, "We are constantly challenged by our franchisees to become better in all aspects of the business. It's like sitting in the control center with a team made up of brilliant entrepreneurs all pushing to succeed".
First Name:
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November 20th 4pm(pst)click for details


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Zuzu Luxe Liquid Foundation
Zuzu Luxe Liquid Foundation
An oil-free medium to full coverage liquid foundation that covers skin imperfections flawlessly. Our advanced treatment formula provides a weightless finish designed to enhance the natural undertones of your skin. Our liquid foundation creates a smooth complexion while offering sun protection with SPF 18.
Aqua (Infusion of Aloe Barbadensis Leaf Juice)
Plant oils
Cetearyl Alcohol
Coconut and palm oils
Calendula Officinalis Flower Extract
Ascorbyl Palmitate
A salt used as a preservative and antioxidant
Tocopheryl Acetate
Vitamin E derived from Coconut Oil
Plant derived used for fragrance
Cellulose Gum
Cell walls of plants
Non GMO soy
Group of minerals used for color
Xanthan Gum
various plant cells i.e. cotton
Cetyl Alcohol
Mixed plant waxes
China clay
Iron Oxides
Several natural oxides of iron used for color
Ultra Marines
Mineral blue pigment
Titanium Dioxide
Mineral functions as a natural sunblock
Potassium Sorbate
Plant derived functions as a food grade preservative
Customer feedback
Customer Reviews
Author: Sara Jefferson
The make up itself isn't bad, but I hate the bottle. The pump makes it nearly impossible to get just a small amount if that's all you need, and it sprays make up every which way. I've ended up with the make up on my clothes and on my bathroom walls because it's unpredictable pump. -
Author: Jeannine
I love this product. It sinks into my skin invisibly yet evens out my redness. I know what Sara means about the pump, mine too is rather explosive. -
Author: Susan
I haven't had any problem with the bottle. Maybe, Sara's is defective. I love the make-up! -
Author: Eve
I love this foundation. After years of struggling with acne, it is the only foundation that I have tried that doesn't give me pimples. I was desperate when my local Wholefoods stopped carrying it, I am glad I found it on this site. -
Author: Cori
I love this foundation but I really wouldn't call it a foundation - its more of a tinted moisturizer. Its pretty sheer, but is enough to even out skin tone. I have it in L6 which is perfect for my NC15-20 skin tone. I did not receive the foundation in a pump, mine is in a squeeze tube which I really like. As another reviewer said, this hasn't broken me out either and even has sunscreen! Great foundation! -
Author: ludmila
I'm glad I ordered samples before purchasing a full size product - the colours are slightly confusing, with those that are "with pink" actually being more orange. This is definitely NOT a "medium-to-full coverage" foundation, it's a very light tinted moisturizer, but a really good one! Has the smoothest texture, semi-matte but not powdery finish, blends in invisibly, giving the skin that "porcelain" surface and such a soft feel! I've tried several natural foundations/tinted moisturizers and this is the best so far, for the best price too! The added SPF is a bonus that seals the deal for me! -
Author: Rose
Have used this for the past 4 years & I do not break out with it.
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