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Renata Batista-Brito, Elsa Rossignol, Jens Hjerling-Leffler, Myrto Denaxa, Michael Wegner, Véronique Lefebvre, Vassilis Pachnis and Gord Fishell
SummaryWe describe the role of Sox6 in cortical interneuron development, from a cellular to a behavioral level. We identify Sox6 as a protein expressed continuously within MGE-derived cortical interneurons from postmitotic progenitor stages into adulthood. Both its expression pattern and null phenotype suggests that Sox6 gene function is closely linked to that of Lhx6. In both Lhx6 and Sox6 null animals, the expression of PV and SST and the position of both basket and Martinotti neurons are abnormal. We find that Sox6 functions downstream of Lhx6. Electrophysiological analysis of Sox6 mutant cortical interneurons revealed that basket cells, even when mispositioned, retain characteristic but immature fast-spiking physiological features. Our data suggest that Sox6 is not required for the specification of MGE-derived cortical interneurons. It is, however, necessary for their normal positioning and maturation. As a consequence, the specific removal of Sox6 from this population results in a severe epileptic encephalopathy.
Summary | Full Text | PDF (4910 kb) - A Modular Gain-of-Function Approach to Generate Cortical Interneuron Subtypes from ES Cells
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SummaryWhereas past work indicates that cortical interneurons (cINs) can be generically produced from stem cells, generating large numbers of specific subtypes of this population has remained elusive. This reflects an information gap in our understanding of the transcriptional programs required for different interneuron subtypes. Here, we have utilized the directed differentiation of stem cells into specific subpopulations of cortical interneurons as a means to identify some of these missing factors. To establish this approach, we utilized two factors known to be required for the generation of cINs, Nkx2-1 and Dlx2. As predicted, their regulated transient expression greatly improved the differentiation efficiency and specificity over baseline. We extended upon this "cIN-primed" model in order to establish a modular system whereby a third transcription factor could be systematically introduced. Using this approach, we identified Lmo3 and Pou3f4 as genes that can augment the differentiation and/or subtype specificity of cINs in vitro.
Summary | Full Text | PDF (4494 kb) - Directed Migration of Cortical Interneurons Depends on the Cell-Autonomous Action of Sip1
Directed Migration of Cortical Interneurons Depends on the Cell-Autonomous Action of Sip1
Neuron, Volume 77, Issue 1, 9 January 2013, Pages 70-82
Veronique van den Berghe, Elke Stappers, Bram Vandesande, Jordane Dimidschstein, Roel Kroes, Annick Francis, Andrea Conidi, Flore Lesage, Ruben Dries, Silvia Cazzola, Geert Berx, Nicoletta Kessaris, Pierre Vanderhaeghen, Wilfred van IJcken, Frank G. Grosveld, Steven Goossens, Jody J. Haigh, Gord Fishell, André Goffinet, Stein Aerts, Danny Huylebroeck and Eve Seuntjens
SummaryGABAergic interneurons mainly originate in the medial ganglionic eminence (MGE) of the embryonic ventral telencephalon (VT) and migrate tangentially to the cortex, guided by membrane-bound and secreted factors. We found that Sip1 (Zfhx1b, Zeb2), a transcription factor enriched in migrating cortical interneurons, is required for their proper differentiation and correct guidance. The majority of Sip1 knockout interneurons fail to migrate to the neocortex and stall in the VT. RNA sequencing reveals that Sip1 knockout interneurons do not acquire a fully mature cortical interneuron identity and contain increased levels of the repulsive receptor Unc5b. Focal electroporation of Unc5b-encoding vectors in the MGE of wild-type brain slices disturbs migration to the neocortex, whereas reducing Unc5b levels in Sip1 knockout slices and brains rescues the migration defect. Our results reveal that Sip1, through tuning of Unc5b levels, is essential for cortical interneuron guidance.
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Copyright © 2011 Elsevier Inc. All rights reserved.
Neuron, Volume 71, Issue 6, 995-1013, 22 September 2011
Add/View Comments (0)A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex
Hiroki Taniguchi1, Miao He1, Priscilla Wu1, Sangyong Kim1, Raehum Paik1, Ken Sugino2, Duda Kvitsani1, Yu Fu1, Jiangteng Lu1, Ying Lin1, Goichi Miyoshi3, Yasuyuki Shima2, Gord Fishell3, Sacha B. Nelson2 and Z. Josh Huang1, ,
1 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
2 Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02154, USA
3 Smilow Neuroscience Program, Department of Cell Biology, New York University Medical Center, New York, NY 10016, USA
► Generation of ∼20 Cre lines targeting major classes of cortical interneurons ► Intersection of Cre and Flp lines increases specificity of targeting ► Genetic targeting enables systematic and comprehensive analysis of cortical interneurons ► Genetic targeting accelerates the study of GABAergic circuits throughout the mammalian brain
- A key obstacle to understanding neural circuits in the cerebral cortex is that of unraveling the diversity of GABAergic interneurons. This diversity poses general questions for neural circuit analysis: how are these interneuron cell types generated and assembled into stereotyped local circuits and how do they differentially contribute to circuit operations that underlie cortical functions ranging from perception to cognition? Using genetic engineering in mice, we have generated and characterized approximately 20 Cre and inducible CreER knockin driver lines that reliably target major classes and lineages of GABAergic neurons. More select populations are captured by intersection of Cre and Flp drivers. Genetic targeting allows reliable identification, monitoring, and manipulation of cortical GABAergic neurons, thereby enabling a systematic and comprehensive analysis from cell fate specification, migration, and connectivity, to their functions in network dynamics and behavior. As such, this approach will accelerate the study of GABAergic circuits throughout the mammalian brain.


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The powerful, classic design of the Cobalt V does not fail to make an impression. The solid titanium, 44mm case is subtly rounded and finished in rugged black vacuum-ion plating. Over-sized numbers in the latest "GRADE A" Swiss Superluminova are enhanced by bold geometric hands for unparalleled legibility. The new technology V-Series movement boosts battery life to an impressive 5 years. Each watch has a professional screw-down crown and is waterproof tested to a depth of 100m/330 ft.

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Imipramine Inhibition of Transient K Current: An External Open Channel Blocker Preventing Fast Inactivation Biophysical Journal, Volume 75, Issue 6, 1 December 1998, Pages 2845-2857 Chung-Chin Kuo Abstract Rapidly inactivating K+ current (KA current) is recorded from rat hippocampal neurons by whole-cell patch-clamp technique and suitable voltage protocols. It is found that imipramine, a commonly prescribed tricyclic antidepressant, is an open KA channel blocker with a binding rate constant of 5.6×106 M−1 s−1 and an apparent dissociation constant of no more than 6μM if applied extracellularly in pH 7.4. The inhibitory effect is more pronounced in more alkaline extracellular solution, suggesting that the neutral form of imipramine is much more active than the charged form. In contrast, intracellular imipramine shows no inhibitory effect. Furthermore, the inhibitory effect of imipramine is antagonized by external but not internal K+. These findings suggest an imipramine binding site located close to the external pore mouth. It is also found that the inactivation curve of KA current is not changed by imipramine. Moreover, the recovery of KA current after a step depolarization is accelerated in the presence of imipramine. These findings suggest insignificant binding of imipramine to the fast inactivated KA channel. The selective binding of imipramine to only the activated but not the deactivated or inactivated states seems to suggest continual gating conformational changes in the external pore mouth of these neuronal KA channels during membrane depolarization. Abstract | Full Text | PDF (199 kb) |
Amitriptyline is a TrkA and TrkB Receptor Agonist that Promotes TrkA/TrkB Heterodimerization and Has Potent Neurotrophic Activity Chemistry & Biology, Volume 16, Issue 6, 26 June 2009, Pages 644-656 Sung-Wuk Jang, Xia Liu, Chi-Bun Chan, David Weinshenker, Randy A. Hall, Ge Xiao and Keqiang Ye Summary Neurotrophins, the cognate ligands for the Trk receptors, are homodimers and induce Trk dimerization through a symmetric bivalent mechanism. We report here that amitriptyline, an antidepressant drug, directly binds TrkA and TrkB and triggers their dimerization and activation. Amitriptyline, but not any other tricyclic or selective serotonin reuptake inhibitor antidepressants, promotes TrkA autophosphorylation in primary neurons and induces neurite outgrowth in PC12 cells. Amitriptyline binds the extracellular domain of both TrkA and TrkB and promotes TrkA-TrkB receptor heterodimerization. Truncation of amitriptyline binding motif on TrkA abrogates the receptor dimerization by amitriptyline. Administration of amitriptyline to mice activates both receptors and significantly reduces kainic acid-triggered neuronal cell death. Inhibition of TrkA, but not TrkB, abolishes amitriptyline's neuroprotective effect without impairing its antidepressant activity. Thus, amitriptyline acts as a TrkA and TrkB agonist and possesses marked neurotrophic activity. Summary | Full Text | PDF (2020 kb) |
Orientation and Dynamics of Melittin in Membranes of Varying Composition Utilizing NBD Fluorescence Biophysical Journal, Volume 92, Issue 4, 15 February 2007, Pages 1271-1283 H. Raghuraman and Amitabha Chattopadhyay Abstract Melittin is a cationic hemolytic peptide isolated from the European honey bee, Apis mellifera. The organization of membrane-bound melittin has earlier been shown to be dependent on the physical state and composition of membranes. In this study, we covalently labeled the N-terminal (Gly-1) and Lys-7 of melittin with an environment-sensitive fluorescent probe, the NBD group, to monitor the influence of negatively charged lipids and cholesterol on the organization and dynamics of membrane-bound melittin. Our results show that the NBD group of melittin labeled at its N-terminal end does not exhibit red edge excitation shift in DOPC and DOPC/DOPG membranes, whereas the NBD group of melittin labeled at Lys-7 exhibits REES of ∼8nm. This could be attributed to difference in membrane microenvironment experienced by the NBD groups in these analogs. Interestingly, the membrane environment of the NBD groups is sensitive to the presence of cholesterol, which is supported by time-resolved fluorescence measurements. Importantly, the orientation of melittin is found to be parallel to the membrane surface as determined by membrane penetration depth analysis using the parallax method in all cases. Our results constitute the first report to our knowledge describing the orientation of melittin in cholesterol-containing membranes. These results assume significance in the overall context of the role of membrane lipids in the orientation and function of membrane proteins and peptides. Abstract | Full Text | PDF (324 kb) |
Copyright © 1992 The Biophysical Society All rights reserved.
Biophysical Journal, Volume 63, Issue 2, 569-572, 1 August 1992
Research Article
H. Tanaka, K. Matsunaga and H. Kawazura
Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
A dynamic 23Na nuclear magnetic resonance (NMR) technique was applied to the exchange system of Na+ ions present inside and outside large unilamellar vesicles at an equivalent concentration. Addition of melittin to phosphatidylcholine vesicles did not induce any detectable Na+ transport across the membrane but subsequent addition of a trace of chlorpromazine or imipramine did induce Na+ transport. Because the formation of a drug-melittin adduct in a solution was detected by 1H NMR, the activation of melittin channels was assumed to originate from the direct interaction of the drug and melittin.


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OIRA staff members and graduate students are listed below along with their contact information. For our office location and phone and fax information, please see the Contact page.
Lorne KuffelExecutive Director
Michael R. O'Rear, Ph.DAssociate Director
Julianna ProctorAssistant Director
Leticia WorthingtonAdministrative Analyst
Holly S. KennedyInstitutional Research Specialist
Jon C. Acker, Ph.D.Coordinator for Student Assessment
Samual C. StrotherInstitutional Research Analyst Senior
Alicia Weaver, Ph.D.Institutional Research Analyst Senior
Christine Kraft, Ph.D.Institutional Research Analyst
Julia S. McAdamsInstitutional Research Analyst
Bob ZuercherInstitutional Research Analyst
Longfei WangInstitutional Research Analyst
Andy Akin, Ph.DInstitutional Research Analyst
Jason PhillipsWeb Resources Integration Analyst Senior
Elizabeth StanleyWeb Resources Integration Analyst


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The Congenital Heart Walk is an ongoing national effort between the Adult Congenital Heart Association (ACHA) and The Children's Heart Foundation (CHF). We walk to honor and remember the millions who have been impacted by congenital heart disease (CHD). The Congenital Heart Walk shows the nation how a team of inspired individuals can join together to make a difference. Funds raised will support the missions of both national nonprofit organizations who are uniting to fight CHD!
This year, thousands of individuals and hundreds of teams will unite at over 25 nationwide locations! Find a walk in your area and register today to show the world it is time to fight CHD.
Date: Saturday, February 8, 2014
Time: 5:30 p.m. – 8:00 p.m.
Place: J. Buck's, 101 S. Hanley Road St. Louis, MO 63105
About the event: You will have the opportunity to engage in a panel discussion led by ACHA Heart to Heart Ambassadors and a CHD cardiologist, and connect with other adults living and thriving with a CHD and family members of those living with CHD.
For more information, click here.
To RSVP, please visit this link.
Looking for something special to do with your valentine? Emmerich Events is hosting the Heartiversary Gala on Saturday, February 15th. The night will include light refreshments, beer, wine and soda, door prizes, auctions and lots of dancing. The event is being held at The Barristers Club in Allentown from 7 p.m.-11 p.m. There are a number of options ranging from individual and date night tickets to a VIP table. Proceeds from this event will benefit ACHA. To learn more or to buy your tickets click here. We hope to see you there!
Membership is free! You'll get materials, discussion forum access, event invitations, e-communications and more.
ACHA professional members receive materials discounts, plus other benefits.
Access our searchable tool to learn more about current ACHD programs.
The ACHA/ISACHD ACHD Clinic Directory offers comparative information on ACHD clinics in the U.S. and Canada.


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text: Last month our nation stood horrified at the tragedy that took place in Newtown. Life as MOM contributor Jessie Leigh lives just down the road from this community. Her husband had been in the school just hours before. Today she shares insightful thoughts on how to go on. Photo source: Caitlinator… Read the whole story »


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The Endocrine Society today issued a Clinical Practice Guideline (CPG) for the diagnosis and treatment of polycystic ovary syndrome, the most common hormone disorder in women of reproductive age and a leading cause of infertility.
The CPG, entitled "Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline" will appear in the December 2013 issue of the Journal of Clinical Endocrinology and Metabolism (JCEM), a publication of The Endocrine Society.
Polycystic ovary syndrome, or PCOS, affects about 5 million women in the United States, according to the National Institutes of Health. The condition causes diverse symptoms, and its causes are poorly understood. The definition and even the name of PCOS have been subject to debate. An NIH panel concluded in January 2013 that the name's focus on a specific symptom - ovarian cysts - that is not present in all PCOS cases caused confusion about the condition. Three separate diagnostic classification systems have been developed to help identify PCOS.
"The Endocrine Society's CPG is designed to help physicians and patients navigate our evolving understanding of this complex condition," said Richard S. Legro, MD, of the Penn State University College of Medicine, and chair of the task force that authored the guideline. "The Society's recommendations allow physicians to make the diagnosis if clear symptoms are present without resorting to universal hormone tests or ultrasound screening."
In the CPG, The Endocrine Society recommends that a diagnosis be made if adult women have two of the three cardinal features of PCOS (diagnostic criteria supported by the NIH panel): • Excess production of male hormones called androgens. • Anovulation, a condition where the ovary does not release a mature egg each month. This causes irregular menstrual cycles. • The formation of clusters of pearl-size cysts containing immature eggs in the ovaries, which is called polycystic ovaries.
Other recommendations from the CPG include:
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Search By Feature: Children Welcome
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Relax to the sounds & beauty of Fall River. We are perfectly located halfway between the Village of Estes Park & Rocky Mtn National Park (2.5 mi each way). Enjoy a furnished 1,2, or 3 bedroom vacation condo with a full kitchen, jacuzzi spa tub or hot tub, fireplace, & gas grill. Each bedroom has it's own bath! Save $'s - cook breakfast in, then grill dinner. Winter deals & packages available. Details
Relax on your front porch just a few feet from the water's edge. Our intimate, authentic western resort offers a tranquil setting to get away from it all! Grab a pole & cast your line into our stocked trout pond, or enjoy wine & cheese as the sun sets. All units with King beds, kitchens, and stylish baths. Lovely shaded grounds. Just 3.5 mi. west of Lyons off Hwy 36.
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On the banks of the Big Thompson River, Tiny Town Cabins sit on 12 acres of private mountain meadow. We're an ideal destination for couples looking for a Rocky Mountain getaway. Cabins feature wood-burning fireplaces and full kitchens. Each cabin is unique... check our website to see cabin photos and floorplans. Tiny Town is just five minutes from the main park entrance. Details
Enjoy one of the best kept secrets of Estes Park. Kitchens equipped w/ most of your culinary needs. TV and DVD player in each cabin. Fresh hot homemade muffins are delivered to your door each morning except Sunday. Hikers mark new paths while walking in the solitude of the forests. The river is your front yard and RMNP your backyard. Relish intimate time in your own private hot tub. Details
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Luxurious vacation homes (3-6 bedrooms) in a quiet setting with river and mountain views. We have homes that sleep from 2-22 people. Homes include fully-equipped kitchens, fireplaces, cable TV, DVD, decks, gas grills, free Wi-Fi, and a playground. Two miles to RMNP. Details
Leave the fast lane, cross our covered bridge to simple serenity in a cozy cottage, suite, room or vacation home in towering pines along Fall River. Fish our well-stocked river. Roam 30 acres adjoining Rocky Mtn. Nat. Park. Bask in hot tub bubbles. Enjoy a wood-burning fireplace, a convenient kitchen, our playground, the river's lullaby, wandering wildlife and friendly gatherings in our library. Details
Panoramic mountain views and richly-appointed condos await you! Relax in spacious, modern one- two- and three-bedroom units with hot tubs, kitchens, fireplaces, and free Wi-Fi. Restaurant, lounge, and the historic Marys Lake Lodge just steps away. Details
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1, 2 and 3 bedroom cottages with kitchens and fireplaces in a beautiful, secluded location in Rocky Mountain National Park, yet very near to town. Small pets accepted. Open late May to October. Details
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Wall-to-wall windows grace our river front suites, allowing for breathtaking mountain views fringed with majestic pines and unique rock formations. One and Two bedroom suites feature separate living rooms, fireplaces and jetted tub. Our inroom spa suites are perfect for honeymoons, anniversaries or just a special time for rest and relaxation! Details
Best rates, nice & clean rooms, suites with balcony, family units with kitchens, free Wi-FI, all rooms non-smoking, AC and refrigerator, heated pool, hot tub, BBQ grill area, close to 18-hole golf course, Rocky Mountain National Park, restaurants, town and all events at the fairgrounds. Details
The Swiftcurrent Lodge is a short 300 yard walk to Rocky Mountain National Park. The Big Thompson River flows through our backyard. Enjoy hiking, wildlife, fishing, birding, photography & much more. Treat yourself to a soak in our riverside hot tub. Some units w/ kitchens & fireplaces. Catering to singles, couples, & small families. Exceptionally clean & affordable with a relaxing atmosphere, personality & charm. 970-586-3720. Details
Studio, 1 and 2-bedroom Cabins. Some Fireplaces or Jetted tub. We are located near Estes Park & Boulder. Relax on 45 scenic acres with views, wildlife, and hiking. Pool, cable TV, free WiFi, phone are all included. Great dining, shops in close-by Lyons - just 2 mi. W of Lyons on Hwy 36. Details
Overlooking Trout Haven Pond, the lodge will accomodate up to 30 people - the perfect wedding, family reunion, and retreat place. All units have full kitchen, fireplace, deck, hot tub, and free WiFi. Our on-site Events Center is newly remodeled with kitchen area. Suitable for business meetings, banquets, and get-togethers of all kinds. Details
Saddle and Surrey offers a variety of nice clean rooms. We are located in Estes Park 1 1/2 miles south on Hwy. 7, one block from the 18 hole golf course. Near fairgrounds and Rocky Mountain National Park. Restaurants within 1 mile. Enjoy your stay! Details
Log cabins with personal hot tubs and sparkling clean 1-, 2- and 3-bedroom cabins. The cabins include furnished kitchens, fireplaces, picnic tables, grills, playground, and free Wi-Fi. Pet friendly. Open all year. Winter specials. Details
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One and two-bedroom condos, Jacuzzi and hot tub suites, fireplaces, kitchens, and decks with spectacular views of Fall River and Deer Mountain. Enjoy the heated outdoor pool (seasonal) and hot tub. We are located one mile from R.M.N.P. Open all year. Call for winter specials. Details
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3 Diamond AAA approved. Free hot continental breakfast. We offer many 2 bedroom, 2 bath loft units with balconies. Whirlpool & outdoor pool. All units are air-conditioned. Family owned and operated. Closed annually from Nov. 1 through mid April. We take reservations all year. Details
Ideally located midway to downtown Estes Park & RMNP, our picturesque property is nestled in 6 acres with abundant wildlife right on the Big Thompson River. We have the perfect place for either your romantic getaway or dream family vacation in the Rockies! Offering river views, mountain vistas, delightfully themed cabins, private decks, and hot tubs, you're sure to be glad you came. Details
Enjoy charming, non-smoking cabins on Big Thompson River, only a half mile from RMNP & YMCA. Cabins include elec. kitchens, CCTV, fireplaces, riverside deck, BBQs, and fishing. Riverwalk w/fabulous views! 3 private spas. Pets welcome. Free video library. FREE Wi-Fi. Details
A distinctive estate community of tastefully appointed, fully furnished vacation homes, and condominiums nestled within 240 wooded acres on Rams Horn Mountain. These homes feature breathtaking views of Rocky Mountain National Park and the Continental Divide. Details
You have never seen a Y like this! We offer over 200 family cabins ranging from 2-4 bedrooms which can hold up to 10 people, and a variety of hotel style lodge rooms, holding up to 6 people. Be close to the main campus and activities or far from it all in secluded woods. Many free activities are available with your stay; we offer more activities onsite than any other area property! Details
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Located within minutes of gorgeous Rocky Mountain National Park, Anderson Realty & Management, home of EstesParkRentals.com, proudly offers a variety of accomodations for 2 to 10 guests, from classic cabins in the woods to distinctive homes and condos with all the comforts of home. All of our units have full kitchens, TV, most with laundry facilities and BBQ, some with internet. Details
Hot Tubs, Woodstoves, Secluded, Outdoor Fireplace for campfire, WiFi. Charming, pet friendly, private vacation cabins off Hwy 7 in Allenspark and Raymond, conveniently located between Lyons and Estes Park. Choose directly on the Middle St Vrain River OR on spacious, wooded acreage bordered by the famous crystal clear Willow Creek. Year round-Great Value! Details
Estes Park Cabins, rooms, and suites bordering Rocky Mountain National Park! Enjoy wood-burning fireplaces and fully-equipped kitchens with a hot tub on-site. Free Wi-Fi, dog friendly (w/ conditions). Spectacular views and great wildlife watching! The perfect place for your mountain getaway! Details
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Stay in one of our Fall River cabins, a relaxing room on the river, or an economical unit in Old Man Mountain Lodge. Fish for trout, enjoy our outdoor hot tub, let the kids have fun in our playground, play horseshoes, sit by our riverside campfire before climbing into bed, or just relax and watch the diverse wildlife. We love our military and repeat visitors; don't forget to ask for those discounts! Details
Quiet, Scenic, Modern & Convenient. River-front cabins, swimming, hot tubs, fireplaces, great wildlife watching, fishing on Fall River. Only 3 minutes to town and to the National Park. Details
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Escape to the serenity of the Rockies! Cozy, comfortable cabins and cottages on the Big Thompson river. Some rooms with fireplaces. Playground, outdoor fireplace, hiking trails, wildlife, and fishing right outside your door. Pet friendly. Overnighters welcome. Open year round. Details
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Nestled in the pines on the banks of Fall River, the Ponderosa Lodge is a place set apart. You feel it as soon as you turn down the drive, a one-lane road that winds through the pines and along the river. There is no hustle and bustle at the Ponderosa, just quiet relaxation with the river always murmuring at your doorstep. At night colored lights, a long-standing tradition at the lodge, transform the property into an enchanting home away from home. Details
Close to everything, close to perfect! Enjoy an easy stroll on the paved walkway to Lake Estes and dinner in town. Small, friendly, affordable. * Full range of suites and rooms at ground level * Air conditioning * Free Wi-Fi * Pet-friendly * Modest rates * Smoke-free * Outdoor hot tub * Jacuzzi suite * Details
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Our resort is located by the East Entrance to Rocky Mountain National Park. Rams Horn Village Resort's two-bedroom, two-bath homes are cozy, yet plush. The homes include full kitchens, TVs, VCR/DVDs, gas fireplaces, patios, gas and charcoal grills, outdoor (summer) pool, and year round-hot tubs. We have an exceptionally friendly and service-oriented staff. We are the winner of RCI's Gold Crown designation for the 20th straight year. Details
Family resort nestled on 11 beautifully wooded acres near RMNP. Cabins, suites, heated swimming pool, hot tubs, fireplaces, kitchens, gas grills, free wireless Internet, and lodge with pool table. Some units are pet friendly. Open all year. Winter specials. Details
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Nestled into the trees and rocky outcroppings less than 2 miles from the Fall River entrance to RMNP, this unique 8 1/2 acre property has cabins with private hot tubs or in-room spas, and superb wildlife viewing. We specialize in both family and pet friendly cabins, and romantic getaways. Details
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Tucked away next to Rocky Mtn Natl Park, and only 3 miles from Estes Park is our quiet piece of paradise. Set on 15 secluded acres of pines and aspen, our cabins and vacation homes all feature full kitchens for cooking convenience, fireplaces in living room for that special mountain feel, and decks with BBQ for an outdoor space to relax and enjoy the scenery. Your Perfect Vacation Destination! Details
Enjoy LUXURY accommodations with outstanding VALUE. "A Home Away from Home Getaway." 1, 2, and 3-bedroom condos are available. Each condo includes fully applianced kitchens, living room fireplaces, and private decks overlooking Fall River. Private hot tubs & spa suites are also available. We are located only 1 mile to RMNP, 3 miles to Downtown. FREE: Stocked river fishing, Wi-Fi, local calls, movies, games, indoor, & outdoor activities. Details
Wanting to be on the River or perhaps up on the Mountainside for the most fabulous views? We have both locations offering upscale spacious cabin suites, condos, & studios, all with luxurious down bedding & all are beautifully appointed. Most with kitchens, fireplaces, some with outdoor or fireside hot tubs, and private decks, wildlife, adj. to Rocky Mountain National Park. Cable TV, DVD, Stereo, Phone, BBQ, Wi-Fi, and playground. Details
New luxury riverfront cabins! Romantic 1-bedroom cabins with in-room spa tubs, 2-bedroom family cabins. Fireplaces, riverfront decks, kitchens, gas grills, outdoor hot tub, fishing are all included. We are only 1.5 miles from National Park and 3 miles from shopping. Details
Come to our riverfront property and enjoy the abundance of wildlife. Wood-burning fireplaces, riverfront decks, kitchen, kitchenettes, gas grills, picnic area, playground, trout fishing, & private hot tub cabins. 2 miles from the NP & 2 miles from the town of Estes. Details


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marcun's Gallery Comments
Goodwood Festival of Speed 2013 (1) Cheers guys have just posted another shot from the day, thanks again. By: marcun |
thabks guys very much appreciated By: marcun |
thanks trev much appreciated By: marcun |
Thanks guys really appreciate your kind comments By: marcun |
Incredible mate I would love to shoot one of these great shot By: richmowil |
Wow love this great shot By: catherinecasey |
Keith, thanks for taking the time to evaluate my picture, looking at the we exif data I have supplied and bearing in mind the flash was on its lowest setting and zoomed in to its maximum what would you suggest I do with my exposure settings, I have an original raw file too do you have any thoughts on what I could do with that. By: marcun |
Thanks bren, I think you could be right about the yellow cast, I will do some work on it, also will try a crop too as you have suggested rt hanks again, its funny but when you get good critique like yours you see the opportunity to make it better immediately, just wish I saw it before. Thanks again By: marcun |
Incredible. By: senn |
Absolutely beautiful shot By: Shedboy |
Thanks for your comments they are very much appreciated particular thanks to fefe for your mod I really like it, as i said this was my first real attempt at this and I am very much looking forward to my second would lohe to capture a bird in flight ideally too. By: marcun |
Thanks Guys I have a couple of other shots which I will upload, this was my first attempt at this and I take your point about shooting near the food not at it, there was a tree that they perched in near the food so I will shoot that next time, i suppose i was being a little lazy and it was easier to shoot them at the food as less movement on my point kept them confident. By: marcun |
Wow and er Wowthis is magnificent By: andy210966 |
nice, I really like this I am playing around with water and paint drops at the moment but I have yet to get something like this. By: andy210966 |
Thank you very much By: marcun |
this is one i was looking for but couldnt nail it great capture By: woodlandlad |
thanks, yeh it took a while and i nearly didnt try at all got a little put off with the tutorials all being for off camera flash set ups which i have yet to get the equipment for, mounted my flash on the hot shoe and had a blast anyway, it is not in the same league as some of the shots i was trying to mimic but i was quite happy with it. thanks again By: marcun |
nice, great image of shakey, 3rd in the championship looking good & not only in this photo!!!! By: TripleBlue |
Love this, great capture, love the concentration on his face and the sharpness of the image. By: TripleBlue |
Thanks for your comments, I agree about the road I would also have liked to have taken the shot earlier at a greater angle to see more of the front of the car aswell. By: marcun |
love this bags of charachter By: genebalun |
Love this really great piece of work. By: NDODS |
Thank you very much Nathan, this was only my second year of going but I took my father in law who goes every year and can even remember the first meeting they held there which he attended, unfortunately for the gentleman in this particular image this was just prior to him rolling the car into the hedge right in front of our position, I am pleased to report he was not injured and after the marshalls turned the car up the right way he was able to drive it back to the paddock. Thanks again for you comment it is very much appreciated. By: marcun |
Thanks guys. By: marcun |
wow, that is an incredible shot, you must be extremely pleased, you certainly should be, click. By: javam |


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What a difference a temp table makes over a table variable
Posted by: Denny Cherry
SQL Server, Statistics, Table Variables, Temp Tables
I was working on performance tuning the data deletion process that I use to remove data from our database. We delete massive amounts of data on a daily basis, so our data deletion process is pretty important to us. As we've grown our customer base the amount of data to be deleted every day has...


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DEFTONES frontman Chino Moreno joined THE DILLINGER ESCAPE PLAN on stage last night (Thursday, May 2) at the fifth annual Revolver Golden Gods award show presented by Epiphone at Club Nokia in Los Angeles, California to perform a rocked out version of DEPECHE MODE's "Behind The Wheel". Video footage of the band's appearance can be seen below.
THE DILLINGER ESCAPE PLAN's fifth full-length album, "One Of Us Is The Killer", will be released on May 14 through the band's own Party Smasher Inc., in partnership with Sumerian Records in North America. Party Smasher's partnership with BMG covers the rest of the world, including licensing deals with Grind House for Japan and Remote Control in Australia. "One Of Us Is The Killer" was recorded in Southern California with longtime producer Steve Evetts (GLASSJAW, THE CURE, SUICIDE SILENCE), with additional production at guitarist/co-founder Ben Weinman's studio. Mastering will be handled by Tom Baker (DEFTONES, NINE INCH NAILS, BEASTIE BOYS).THE DILLINGER ESCAPE PLAN Gets Bloody For 'Revolver Golden Gods' Performance (Video)
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No, I'm not talking about College Sports. There are some rivalries I really like. One is the Mets and Yankees (which I'm going to next week).
I remember one yankee met game very well. I was about 8 years old. As soon as I walked into the House that Ruth Built, I knew something was wrong. I sat in front of the most annoying Yankee fan. It was some female teenager.
She wouldn't stop asking me why I'm a mets fan. Why the **** did she care? Yankee fans are not the only fans in the world you know. The whole 9 innings this girl tried to recruit me to become a Yankee Fan. Not over my dead body. (Sorry Yankee Fans)
I kept saying NO. Time and time again. But, instead of watching Paul O'Neill hit line drives, she still would not stop. If I was over 18 that day, I would of went Bruce Lee on her.
What did I do wrong that day? I don't think I did anything. So why did I have to sit next to this whatchamacallit? Some people just don't understand what sit down and shut up really means.
Now, this girl is probably crying. This is the last year at Yankee Stadium. she's probably saying to herself,"Why did i waste my time?"
So my message is to you baseball fans: Don't let somebody **** with you at a baseball game or at any other occasion!


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Sign up to start your personal account and save those recipes!
Recipes : Recipe Detail |
Add Email Print |
- Source: Emeril Live EM1B42E
- Dish Type: Sauces
- Tweet
Maytag Blue Sabayon Sauce
Combine all of the ingredients in a small stainless-steel bowl. Set the bowl over a pot of simmering water and whisk until the mixture begins to thicken, about 2 minutes. Remove from heat.
Yield: about 3/4 cup
- 3 large egg yolks
- 2 teaspoons minced shallots
- 1/3 cup Maytag blue cheese, crumbled
- 1/4 teaspoon salt
- 1/8 teaspoon freshly ground white pepper
- 1 teaspoon snipped fresh chives


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More About Me
Reasons why I prefer to eat vegetarian or vegan:
I was raised mostly by my mother's catholic beliefs, but my father is a Buddhist. He has taught me great valuable things slowly throughout the years and there are many things that I am begining to understand. One of them being our souls. I chose not to eat meat because I believe that when we go on to our next life we are taking our karma with us. I strongly believe in non-violence towards any living thing and don't want to take their pain and suffering with me.
I joined HappyCow Members Community because:
I found it on google, and I just needed support for my Vegan journey :)
Here are some places I've been that I liked... and places that I would like to visit one day:
My country Venezuela (beautiful nature). I would love to go to India, Italy, and Costa Rica.
Some of my favorite veg*n foods include:
Asian rolls, any veggy soup, anything with butternut squash..yummyy
Here are some books, movies, magazines, and my favorites that I would recommend to other HappyCow members:
I recommend "EatPrayLove", and "El Poder del Ahora"(The power of Now)-by Eckhart Tolle.


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Since 1991, Phillips Edison* has invested more than $1.8 billion in neighborhood and community shopping centers, building a portfolio of more than 250 assets totaling 26 million square feet in 35 states.** The company's expertise in maximizing each asset's value has made it one of the country's largest privately-held owner/operators of this property type. Previously, this remarkable growth has been funded by institutional investors, pension funds, high net-worth individuals and other major investors.
Now, Phillips Edison & Company has joined forces with American Realty Capital to enable participation by individual investors who might not have qualified for the previous funds. The formation of Phillips Edison-ARC Shopping Center REIT Inc., ("Phillips Edison-ARC") opens new doors for a growing company and offers solid opportunities for new investors.***
*Phillips Edison refers to our Phillips Edison sponsor and its affiliates, including the property manager and sub-advisor.
**Certain private funds managed by Phillips Edison have been adversely affected by past economic conditions. Specifically, some of the properties owned by one of Phillips Edison's private funds were acquired from 2005 through 2007, during a market period characterized by historically low capitalization rates. Subsequent to these acquisitions, market conditions weakened and, as a result, the value of certain properties declined.
***Past performance of Phillips Edison and/or American Realty Capital is no guarantee of future results. Investors are not being offered securities in the advisor or the sponsor.
1/13/14. Year End 2013 Closed Out with 11 Acquisitions Read More>>
1/6/14. Announcemnt of Unsecured Credit Facility with up to $600 MM in Availability Read More>>
12/05/2013. Three Grocery-Anchored Centers Acquired Read More>>
Phillips Edison-ARC Video |


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Curried Beef with Peanutty Coconut Sauce
Yield: 6 servings (serving size: about 1/2 cup rice and 3/4 cup curried beef). other: 30 minutes
More From Oxmoor House
Recipe Time
Cook Time:
Prep Time:
30 Minutes
Nutritional Information
Amount per serving
- Calories: 332
- Fat: 13.2g
- Saturated fat: 4.2g
- Protein: 27.9g
- Carbohydrate: 24.7g
- Cholesterol: 63mg
- Iron: 3.3mg
- Sodium: 383mg
- Calories from fat: 36%
- Fiber: 3.0g
- Calcium: 25mg
- 2 tablespoons water
- 1 tablespoon red curry paste
- 1 1/2 pounds boneless top sirloin steak, trimmed
- 1 cup uncooked jasmine rice
- 2 teaspoons sesame oil, divided
- 1/2 pound asparagus spears, diagonally cut into 1-inch pieces (about 2 cups)
- 1 cup snow peas, cut in half diagonally
- 1/2 cup shredded carrot (about 1 medium)
- 3/4 cup fat-free, less-sodium chicken broth
- 3/4 cup chopped green onions
- 1/3 cup reduced-fat peanut butter
- 1/3 cup light coconut milk
- 2 tablespoons fresh lime juice
- 1 tablespoon low-sodium soy sauce
- Combine water and curry paste in a large bowl; stir with a whisk until smooth. Cut steak diagonally across grain into 1/4-inch-thick slices; cut slices into thin strips. Add steak to curry paste, tossing to coat. Cover and chill at least 30 minutes.
- . Cook rice according to package directions, omitting salt and fat.
- . While rice cooks, heat 1/2 teaspoon oil in a large nonstick skillet over medium-high heat. Add half of steak; sauté 3 minutes or until steak is done. Remove steak from skillet; keep warm. Repeat procedure with 1/2 teaspoon oil and remaining steak.
- . Heat remaining 1 teaspoon oil in pan over medium-high heat. Add asparagus, snow peas, and carrot; sauté 5 minutes or until vegetables are crisp-tender. Stir in broth and next 5 ingredients; cook 3 minutes, stirring constantly. Return steak to pan; cook 2 minutes or until thoroughly heated. Serve over hot cooked rice.
Curried Beef with Peanutty Coconut Sauce Recipe at a Glance
- COURSE: Main Dishes
- CONVENIENCE: Family
- CUISINE: Indian
- MAIN INGREDIENT: Beef
- COOKING METHOD: Fry
- PUBLICATION: Oxmoor House
More Recipes for Main Dishes
Curried Beef Short Ribs
Cooking Light -
Beef Satay with Thai Coconut-Peanut Sauce
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text: Hi there. I'm using the debian live CD (debian-live-etch-i386- standard.iso, from late February 2007) for a project. I need to boot a system and perform block-level analysis and transport of the disk devices, so I needed a LiveCD type distribution to run on. I've adding a few additional tools to the ISO and squashfs, and rebuilding the image. A problem I've noted is that I'm frequently booting on multi- processor machines with numerous gigabytes of memory. The i386 kernel that's on the above-noted CD claims to cap memory use at below a megabyte, and only allow one processor to be used. From boot messages: Warning only 896MB will be used. Use a HIGHMEM enabled kernel. 896MB LOWMEM available. Processor #0 .... Processor #1 .... WARNING: NR_CPUS limit of 1 reached. Processor ignored. As some of the analyses we're doing of the disk devices contain some fairly-heavy math, there would be an advantage to a second (or even more, if we find more than one controller such that we're trying to read from more than one disk simultaniously) processor. And, clearly, more memory is never bad when doing so much I/O. I took a look at just apt-get install'ing linux-image-2.6-686, to update the kernel on the squashfs (and then copying the pieces out into the ISO), but after doing that the system no longer boots into multiuser, it just stops in busy-box halfway up. So, there's clearly a stage I don't understand about how the LiveCD is put together. What I'm hoping to find on the list is either: 1) a pointer to a 686-kernel LiveCD, so this problem will mostly already be solved, or 2) advice on how to update the kernel on the debian-live-etch-i386- standard.iso image's squashfs (and ISO) maintaining the full LiveCD functionality. Thanks. I hope to hear back from someone soon... - Chris


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Monetary strictness and labour market outcomes under incomplete transparency
This paper extends the workhorse model of strategic wage setting and monetary policy to the case of incomplete central bank transparency. In contrast with the existing literature, the paper shows that an increase in the degree of monetary strictness may lead to a simultaneous rise in real wages and unemployment. This is the likely outcome when the central bank's policies are perceived to be rather accommodating and unpredictable. When monetary policy is instead conducted in a conservative and transparent fashion, we obtain the standard result that greater monetary strictness induces wage discipline and lower unemployment.Download Info
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.
Bibliographic Info
Article provided by Elsevier in its journal Research in Economics.
Volume (Year): 65 (2011)
Issue (Month): 2 (June)
Pages: 95-99
Contact details of provider:
Web page: http://www.elsevier.com/locate/inca/622941
Related research
Keywords: Monetary policy rule Strategic wage setting Central bank transparency;References
References listed on IDEASPlease report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- David Soskice & Torben Iversen, 2000. "The Nonneutrality Of Monetary Policy With Large Price Or Wage Setters," The Quarterly Journal of Economics, MIT Press, vol. 115(1), pages 265-284, February.
- Acocella, Nicola & Di Bartolomeo, Giovanni & Hibbs Jr., Douglas A., 2004.
"Labor market regimes and the effects of monetary policy,"
Working Papers in Economics
145, University of Gothenburg, Department of Economics, revised 22 Apr 2005.
- Acocella, Nicola & Di Bartolomeo, Giovanni & Hibbs Jr., Douglas A., 2008. "Labor market regimes and the effects of monetary policy," Journal of Macroeconomics, Elsevier, vol. 30(1), pages 134-156, March.
- Cukierman, Alex, 2007.
"The Limits of Transparency,"
CEPR Discussion Papers
6475, C.E.P.R. Discussion Papers.
- Alex Cukierman, 2009. "The Limits of Transparency," Economic Notes, Banca Monte dei Paschi di Siena SpA, vol. 38(1-2), pages 1-37, 02.
- Alex Cukierman, 2007. "The limits of transparency," Proceedings, Federal Reserve Bank of San Francisco.
- Gruener Hans Peter & Hayo Bernd & Hefeker Carsten, 2009.
"Unions, Wage Setting and Monetary Policy Uncertainty,"
The B.E. Journal of Macroeconomics,
De Gruyter, vol. 9(1), pages 1-25, October.
- Grüner, Hans Peter & Hayo, Bernd & Hefeker, Carsten, 2005. "Unions, wage setting and monetary policy uncertainty," Working Paper Series 0490, European Central Bank.
- Holden, Steinar, 2005.
"Monetary regimes and the co-ordination of wage setting,"
European Economic Review,
Elsevier, vol. 49(4), pages 833-843, May.
- Steinar Holden, 2001. "Monetary Regimes and the Co-Ordination of Wage Setting," CESifo Working Paper Series 429, CESifo Group Munich.
- Holden,S., 2000. "Monetary regime and the co-ordination of wage setting," Memorandum 01/2000, Oslo University, Department of Economics.
- Coricelli, Fabrizio & Cukierman, Alex & Dalmazzo, Alberto, 2000.
"Monetary Institutions, Monopolistic Competition, Unionized Labour Markets And Economic Performance,"
CEPR Discussion Papers
2407, C.E.P.R. Discussion Papers.
- Fabrizio Coricelli & Alex Cukierman & Alberto Dalmazzo, 2006. "Monetary Institutions, Monopolistic Competition, Unionized Labor Markets and Economic Performance," Scandinavian Journal of Economics, Wiley Blackwell, vol. 108(1), pages 39-63, 03.
- Dai, Meixing & Sidiropoulos, Moïse, 2008. "Central bank's conservativeness and transparency," Research in Economics, Elsevier, vol. 62(4), pages 179-187, December.
- Spyromitros, Eleftherios & Zimmer, Blandine, 2009.
"Monetary accommodation and unemployment: Why central bank transparency matters,"
Economics Letters,
Elsevier, vol. 102(2), pages 119-121, February.
- Eleftherios Spyromitros & Blandine Zimmer, 2007. "Monetary accommodation and unemployment: Why central bank transparency matters," Working Papers of BETA 2007-27, Bureau d'Economie Théorique et Appliquée, UDS, Strasbourg.
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text:
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After returning from their honeymoon and showing ''home movies'' to their friends, Shrek and Fiona learn Fiona's parents have heard their daughter has married her true love, and wish to meet the husband and invite him to their kingdom, called Far Far Away. The catch? Fiona's parents are unaware of the curse that struck their daughter, and assumed she married Prince Charming. They're a bit shocked to learn their son-in-law is a 700-pound ogre with horrible hygeine, and whose companion is a talking donkey. Full synopsis
What Parents Need to Know
Shrek learns to accept himself. But movie also includes some crude potty humor.
Comic violence, no one hurt except a giant gingerbread man.
Plenty of innuendo, especially when Donkey and Shrek take the potions and become "sexy." Some ogre kissing, and mermaid kissing. Pinocchio can't lie that he's wearing ladies' underwear.
Some mild naughty words: "ass," "oh my God," etc.
Plenty of fake commercialism in the commercial district of Far Far Away: retail shops, a version of Starbucks, and fast food.
Brief drug joke -- but the drug is really catnip.


text:
100 Great Things You Can Buy for / With A Dollar
A comprehensive list of items that can be purchased for $1.00 or less. Lists Ebay, The Dollar Tree, Wendy's, Sally's, and Amazon as places to purchase these items.334 comments
How to Have Family Fun While Living on a Budget
Everyone wants to have fun with their family but society can often make it seem that the only way to have fun is to spend money. But few people have the money to spend like we see in the commercials. However, rest assured you can have fun without a...7 comments
How I Get Free Stuff like Dog Food, Clothes, Appliances and More
FreeCycle is a great way to score free stuff, save money and help reduce waste in your local community. There are FreeCycle chapters in almost every major city in the USA and in over 80 countries around the world.3 comments
Thrift Stores and Thrift Shopping
People shop at thrift stores for a variety of reasons. Some go because they can't afford to shop elsewhere. Some go to find hidden treasures. Thrift shopping supports charity and is green, because you are helping find a new use for old items, saving them from the landfill and cutting down on the need for new items to be manufactured.24 comments
21 Frugal Living Tips for Single Moms
I learned these money-saving tips from watching my mom as I was growing up. She taught me how to live frugally, and I have incorporated many of these tips into my own life.177 comments
Frugal Ways to Save Money-from Fashion, To Groceries, to Gasoline.
Ways to save money on everyday items, including gas, fashion, and groceries.2 comments
Frugal Living: 7 Thrifty Ways on How to Save Money on Clothes
Save money on your clothing by making changes in your spending. Make drastic cuts and save hundreds! Swap parties and resale shops are just a few of the ways you can save.22 comments
Latest JCPenney Coupons
Before, you may get far more information about JCPenney printable coupons, you must consider about its vendor. JCPenney is amongst the top retailer's and service vendors in the us. A lot more than thousands of USA industry is going to the service...Ten tips for how to eat on a budget when you're single and living on your own
Ten tips for people living on their own, who wish to cut the cost of their food.17 comments


text:
Interest Level
Grades K - 2
Reading Level
Grade level Equivalent: 2.2
Lexile Measure®: 580
Guided Reading: J
Type of Book: Read-Aloud Book
- Comedy and Humor
- General Nonfiction
- Sun
- Light
About This Book
Bear tries everything he can think of to get rid of his shadow. This charming tale will teach young readers about the origin of shadows and their connection to light. Asch's illustrations take center stage in this picture book, allowing readers to get a clear sense of objects and their shadows. The text is simple enough for young readers to figure out the story on their own, or to follow along as it is read aloud.
Items Added to Cart:
1 Paperback
2 Hardcover
1 Teacher's Edition
$48.99 Subtotal


text:
Please enter your travel dates.
Deluxe Room - Last Minute Deal
Deluxe Room - Net Rate
Executive Room - Last Minute Deal
Executive Room - Net Rate
4-star hotel with an outdoor pool in Bangkok (Sukhumvit)
With a stay at Park Plaza Bangkok Soi 18, you'll be centrally located in Bangkok, walking distance from Embassy of Argentina and close to Benjasiri Park.
This 4-star hotel is within close proximity of Terminal 21 Shopping Mall and Embassy of India.
Make yourself at home in one of the 125 air-conditioned rooms featuring refrigerators and LCD televisions. Complimentary wireless Internet access keeps you connected, and DVD players are provided for your entertainment. Bathrooms have rainfall showerheads and hair dryers. Conveniences include phones, as well as safes and desks.
Don't miss out on the many recreational opportunities, including an outdoor pool, a spa tub, and a fitness center. Additional features include complimentary wireless Internet access and concierge services.
Enjoy a meal at a restaurant, or stay in and take advantage of the hotel's 24-hour room service. While enjoying a refreshing dip in the hotel pool, you can order your favorite drink at the poolside bar.
Featured amenities include a 24-hour business center, limo/town car service, and audiovisual equipment. Guests may use a roundtrip airport shuttle for a surcharge, and free parking is available onsite.
Hotel Amenities
- General
In addition to an outdoor pool, Park Plaza Bangkok Soi 18 provides a spa tub and a fitness center. The hotel offers a restaurant. A poolside bar is on site where guests can unwind with a drink. High-speed wireless Internet access is complimentary.
Business amenities at this 4-star property consist of a 24-hour business center, limo/town car service, and audiovisual equipment. This Bangkok hotel also offers concierge services, laundry facilities, and dry cleaning/laundry services. Onsite parking is complimentary.
- Free Wi-Fi
- Total number of rooms - 125
- Audiovisual equipment
- Business services
- Concierge services
- Dry cleaning/laundry service
- Event catering
- Fitness facilities
- Airport transportation (surcharge)
- Front desk (limited hours)
- Currency exchange
- Free parking
- Laundry facilities
- Elevator/lift
- Express check-in
- Luggage storage
- Poolside bar
- Restaurant
- Room service (24 hours)
- 24-hour business center
- Spa tub
- Swimming pool - outdoor
- Limo or Town Car service available
- Internet
Available in all rooms: Free Wi-Fi
Available in some public areas: Free Wi-Fi
- Parking
Free parking
- Room Amenities
- DVD player
- Phone
- Refrigerator
- Coffee/tea maker
- Daily housekeeping
- Bathrobes
- Hair dryer
- Rainfall showerhead
- Iron/ironing board
- Desk
- Free Wi-Fi
- In-room safe
- Air conditioning
- Dining
Park Plaza Bangkok Soi 18 has a restaurant on site.
24-hour room service is available.
- Recreation
An outdoor pool and a spa tub are on site. Other recreational amenities include a fitness facility.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Swimming on site
Policies & Fees
- Check-in
Check-in time starts at 2 PM
- Check-out
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This article's factual accuracy may be compromised due to out-of-date information. (December 2010) |
This article needs additional citations for verification. (May 2008) |
The N-Prize (the "N" stands for "Nanosatellite" or "Negligible Resources".[1]) is an inducement prize contest to stimulate innovation directed towards obtaining cheap access to space. The competition was launched in 2008 by Cambridge biologist Paul H. Dear, and is intended specifically to spur amateur involvement in spaceflight.[2]
The challenge posed by the N-Prize is to launch a satellite weighing between 9.99 and 19.99 grams into Earth orbit, and to track it for a minimum of nine orbits. Most importantly, though, the launch budget must be within £999.99 (about $1500) - and must include the launch vehicle, all of the required non-reusable launch equipment hardware, and propellant. According to the full rules of the N-Prize, it is "intended to encourage creativity, originality and inventiveness in the face of severe odds and impossible financial restrictions" and "is aimed at amateurs, enthusiasts, would-be boffins and foolhardy optimists."[2]
In order to be eligible for the awards, the winning team must complete the challenge before 19:19:09 (GMT) on 19 September 2013. Doing so will earn the winning team a prize of £9,999.99.[2]
List of competing teams[edit]
Some of the teams that entered the competition at one time or another include:
- Epsilon Vee[4]
- Vulcan[5][not in citation given]
- Microlaunchers[6][not specific enough to verify]
- Cambridge University Spaceflight[7]
- Team 9.99 [8][better source needed]
- Kiwi 2 Space[9][better source needed]
- Qi Spacecraft[10][better source needed][dated info]
- Aerosplice[11][better source needed]
- WikiSat[12]
Wakefield Aerospace, Slidell, Louisiana
See also[edit]
- ^ "Whimsical 'N-prize' to spur ultra-cheap space launches".
- ^ a b c ""Nines" have it for Nanosatellite space race: The N-Prize". ITWire. 2008-05-03. Retrieved 2008-05-17.
- ^ n-Prize Patch, nebula-prize.com team website, "Featured image" page, date unknown, accessed 2010-12-07.
- ^ Epsilon Vee website, 27 Jun 2008, no updates since (accessed 2011-09-21).
- ^ South African Rocketry Association website, copyright 2008, no mention of N-Prize on this webpage
- ^ Microlaunchers website, copyright 2007, unclear when last updated
- ^ To the edge of space for £1,000, guardian.co.uk, 2006-09-16, accessed 2010-12-07.
- ^ Team 9.99, team webpage, undated, accessed 2010-12-07.
- ^ Kiwi 2 Space, Kiwi 2 Space webpage, date unknown, accessed 2010-12-07.
- ^ Qi, Qi blog, last entry 2009-10-02, accessed 2010-12-07.
- ^ Aerosplice, team webpage, date unknown, accessed 2010-12-07.
- ^ Una lanzadera 'low cost' para satelites enanos, elmundo.es, 2012-11-01, accessed 2012-11-18.
External links[edit]
External links[edit]
- N-Prize main website
- N-Prize official Forum
- Team 1 "Nebula Aerospace" Website
- Team 9 "Team Prometheus" Website
- Team 5 "Generation Space" open Official Forums


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Rock On One couple restores authentic Sedona charm to a log home at the base of Cathdral Rock. | ||||
Splish Splash Add fun and function to your log home bathroomwithout taking a bath on your bottom line | ||||
Calendar Check out the latest log home Calendar of Events. | ||||


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"My mother said I must always be intolerant of ignorance but understanding of illiteracy. That some people, unable to go to school, were more educated and more intelligent than college professors."
Maya Angelou
"The only thing more expensive than education is ignorance."
Benjamin Franklin
"Ignorance is the only illness..."
Sedat Seals
"People say they love truth, but in reality they want to believe that which they love is true."
Robert J. Ringer
"The need for an ego boost is responsible for most things people do"
sotonye anga
"To understand people, is an impossible thing for a man or women to accomplish, but to understand a person is to not only know there greatness of success but there flaws in life. That we not only celebrate our success but we celebrate our flaws in life that we have overcome, to respect each others courage that we have shown in ourselves."
Austin J Scime
"A mother takes care of me+other, but a father takes care of his fat+her"
Miteb Khantash Alqarni


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Drums & Percussion : How Much Are Used Pearl Drums... |
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A set of used Pearl drums can be worth varying amounts depending on how old they are, what kind of condition they are in and the type of model. Find out why a vintage Pearl drum set may be worth $3,000 to $5,000 used with help from an experienced drummer in this free video on drums and percussion. Expert: David Pakman Contact: www.midweekpolitics.com Bio: David Pakman is a longtime drummer trained in rock, funk, jazz, blues and music theory, and is also a casual piano/keyboard player. Filmmaker: David Pakman
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After his degree in Industrial Design at the University of " La Sapienza", Rome, in 2007, he begins his activity of design in the department of Research and Development at Slamp. He is currently collaborating in the ideation of new shapes and decors, experimenting new materials and techniques destined to the creation of novel lines of products. This experience has led to the birth of Marie Fleur and Lui, two important products which are intrinsically characteristic of Slamp values.
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New Fed Chair Janet Yellen's prepared remarks for her first day of congressional testimony make it clear that she doesn't want to rock the boat or quickly deviate that boat from its course under Ben Bernanke. In remarks that were notable for their brevity compared to her predecessor, Yellen tries to outline a smooth leadership transition in a speech being delivered the House Financial Services Committee today:
Turning to monetary policy, let me emphasize that I expect a great deal of continuity in the FOMC's approach to monetary policy. I served on the Committee as we formulated our current policy strategy and I strongly support that strategy, which is designed to fulfill the Federal Reserve's statutory mandate of maximum employment and price stability.
Here's her take on tapering:
If incoming information broadly supports the Committee's expectation of ongoing improvement in labor market conditions and inflation moving back toward its longer-run objective, the Committee will likely reduce the pace of asset purchases in further measured steps at future meetings. That said, purchases are not on a preset course, and the Committee's decisions about their pace will remain contingent on its outlook for the labor market and inflation as well as its assessment of the likely efficacy and costs of such purchases.
And here's Yellen discussing forward guidance:
The Committee has emphasized that a highly accommodative policy will remain appropriate for a considerable time after asset purchases end. In addition, the Committee has said since December 2012 that it expects the current low target range for the federal funds rate to be appropriate at least as long as the unemployment rate remains above 6-1/2 percent, inflation is projected to be no more than a half percentage point above our 2 percent longer-run goal, and longer-term inflation expectations remain well anchored. Crossing one of these thresholds will not automatically prompt an increase in the federal funds rate, but will instead indicate only that it had become appropriate for the Committee to consider whether the broader economic outlook would justify such an increase. In December of last year and again this January, the Committee said that its current expectation–based on its assessment of a broad range of measures of labor market conditions, indicators of inflation pressures and inflation expectations, and readings on financial developments–is that it likely will be appropriate to maintain the current target range for the federal funds rate well past the time that the unemployment rate declines below 6-1/2 percent, especially if projected inflation continues to run below the 2 percent goal. I am committed to achieving both parts of our dual mandate: helping the economy return to full employment and returning inflation to 2 percent while ensuring that it does not run persistently above or below that level.
Bonds are starting the day on a weak note, with the ten-year Treasury yield rising to 2.693%, per Tradeweb data.
They Fed met market expectations yesterday by further tapering its bond-purchase program at the same $10 billion rate as it had done at its previous policy committee meeting. Today Bank of America rates strategists say they expect the FOMC will continue to taper by that same $10 billion per-meeting amount, concluding the program in December, and that it sees "a relatively high hurdle to deviating from this path," seemingly meaning it will take a lot more than just a weak employment reportor two to induce the Fed to pause the tapering process. In terms of forward guidance on the Fed's short-term policy rate, BofA says that "with the unemployment rate closing in on their 6.5% threshold, we expect updated guidance soon."
More from BofA:
The FOMC mostly changed the first paragraph of their statement, but not that much. On the positive side, they noted that growth has "picked up in recent quarters," that household and business spending "advanced more quickly," and that the fiscal restraint on growth "is diminishing." Conversely, they continued to note some slowing in housing and said that labor market indicators (rather than conditions) "were mixed but on balance showed further improvement." All told, we read this as a marginally improved outlook. The FOMC continues to see below-target inflation but expects it gradually converging to their 2% objective over time. We continue to expect the Fed to acknowledge that persistently low inflation will delay rate hikes.
Although there had been some speculation that the Fed might refrain from tapering further in light of weakness in emerging markets, the FOMC tapered by $10 bn as we had expected. We see a relatively high hurdle to deviating from this path, which leads to the end of QE3 purchases in December. Somewhat more surprisingly, the FOMC made no substantive changes to its forward guidance. We expect that they will scrap the 6.5% unemployment threshold and shift to more qualitative guidance on the labor market, perhaps as soon as the March meeting.
The Fed did as markets expected it would at its last policy committee meeting under Ben Bernanke's stewardship, continuing the tapering process by lopping an additional $10 billion off its monthly bond buys, bringing its total down to $65 billion in February.
Other than that, and a few small wording changes, the new statement changed very little from the Fed's last statement, including the part about forward guidance:
To support continued progress toward maximum employment and price stability, the Committee today reaffirmed its view that a highly accommodative stance of monetary policy will remain appropriate for a considerable time after the asset purchase program ends and the economic recovery strengthens. The Committee also reaffirmed its expectation that the current exceptionally low target range for the federal funds rate of 0 to 1/4 percent will be appropriate at least as long as the unemployment rate remains above 6-1/2 percent, inflation between one and two years ahead is projected to be no more than a half percentage point above the Committee's 2 percent longer-run goal, and longer-term inflation expectations continue to be well anchored. In determining how long to maintain a highly accommodative stance of monetary policy, the Committee will also consider other information, including additional measures of labor market conditions, indicators of inflation pressures and inflation expectations, and readings on financial developments. The Committee continues to anticipate, based on its assessment of these factors, that it likely will be appropriate to maintain the current target range for the federal funds rate well past the time that the unemployment rate declines below 6-1/2 percent, especially if projected inflation continues to run below the Committee's 2 percent longer-run goal. When the Committee decides to begin to remove policy accommodation, it will take a balanced approach consistent with its longer-run goals of maximum employment and inflation of 2 percent.
The Fed did give Bernanke a friendly send-off in the form of a unanimous vote on the policy statement, sans the customary dissenter or two.
The ten-year Treasury note's yield ticked slightly higher to 2.731%, per Tradeweb data, from 2.708% right before the Fed's statement came out, and the 30-year yield rose to 3.666% from 3.653%.
We're getting closer to the release of the Fed's policy statement this afternoon, and so far the consensus expectations are for the Fed to continue the tapering process. In its latest U.S. fixed-income weekly market report, JP Morgan sees the Fed doing just that while keeping its forward guidance intact as well, despite an unemployment rate that's encroaching on the Fed's stated threshold. From JPM:
First, although data has weakened somewhat over recent weeks—for example, the disappointing December employment report, the cooling in Markit PMI, and weaker consumer confidence—we expect the Fed to taper by another $10bn at this meeting. Indeed, recent Fed commentary suggests that the FOMC will proceed with tapering at a "measured" pace at the upcoming meeting.
Second, despite the fact that the unemployment rate of 6.7% is just 0.2% above the Fed's threshold, we do not expect the Fed to make any changes to its forward guidance at this meeting.
And here's JPM on what this all means for markets:
If the Fed tapers as expected and does not modify its forward guidance, we think the market's tightening expectations should be higher than current levels… [T]he market's expectations for the year-end 2016 Fed funds rate have declined recently and are now below the FOMC voters' projections from the December Summary of Economic Projections. With the unemployment rate just 0.2% above the Fed's threshold, we think markets should price at least as much tightening as the Fed voters' forecast.
All eyes are on the Fed until it concludes its current policy committee meeting tomorrow, and Barclays strategists Rajiv Setia and Anshul Pradha today say they expect the Fed to continue the tapering process at its current pace. Since rates have been falling since the Fed's last meeting, the Fed has less cause for concern that rising rates brought about by tapering could choke off growth. From Barclays:
Given this backdrop, the Fed is likely to continue reducing the pace of purchases at the January meeting and also to upgrade its assessment of economic data during the inter-meeting period. Our economists expect the Fed to reduce the pace by another $10bn, to $65bn, and ultimately exit QE3 by the October 2014 meeting. One potential source of a dovish surprise from the upcoming meeting is a further strengthening of forward guidance; however, we believe this is unlikely given the steps already taken in December. The Fed stated that "it likely will be appropriate to maintain the current target range for the federal funds rate well past the time that the unemployment rate declines below 6-1/2 percent, especially if projected inflation continues to run below the Committee's 2 percent longer-run goal." Given the sharp drop in the unemployment rate and growing proximity to 6.5%, some have suggested that threshold could be lowered. However, the minutes from the December meeting suggest that this is unlikely; consensus exists only for providing qualitative guidance and placing greater emphasis on the inflation outlook.
Barclays says it sees limited room in the near term for a further rate rally from current levels, with the market already pricing in "a benign path for the hiking cycle, with the fed funds rate rising only to 0.75% by YE15 and 1.8% by YE16″ which is largely in line with the latest Fed guidance. Barclays says investors are likely to remain patient with regard to the pricing of the hiking cycle despite the rapid fall in the unemployment rate, but that this dynamic should begin to change as inflation rises from the current low levels. "If our outlook pans out, we believe the market will increasingly test the Fed's guidance in coming months," Barclays writes.
Wall Street Journal Fed-watcher Jon Hilsenrath is out with a story today suggesting the Federal Reserve is prepared to take a second consecutive step in winding down its bond-buying stimulus program at its next policy committee meeting next week, which will be the last such meeting of Ben Bernanke's tenure as Fed chairman. Hilsenrath cites interviews with officials, as well as their public comments, in saying the Fed could cut its monthly bond buys to $65 billion, after trimming them to $75 billion at its December policy meeting from the $85 billion rate that had been in effect since the program's inception. From the story:
The Fed has been buying Treasurys and mortgage bonds in an effort to drive down long-term interest rates and spur spending…
Bond buying is one of two prongs in the Fed's strategy to boost the economy. The other is low interest rates, and Fed officials are once again debating how best to describe their plans for when they eventually begin raising short-term rates.
In December, the Fed said rates would remain near zero "well past" the time when the unemployment rate falls to 6.5%. The Fed is in no hurry to raise interest rates. But because officials have tied their plans to movements in the jobless rate, they see a need to better explain their plans as the jobless rate drops.
At last check, the 10-year Treasury yield is holding steady at 2.84%, mostly unchanged from where it was trading Friday, per Tradeweb data.
JP Morgan says Friday's weak December employment report had the doubly deleterious effect of undermining the value of the unemployment rate as an indicator of when the Fed will tighten its short-term policy rate, while also raising uncertainty about the pace of Fed tapering. JPM points out that the latest 6.7% unemployment rate reading is now very close to the 6.5% level the Fed has cited before:
The December FOMC statement did say said that policy rates would remain low "well after" the unemployment rate fell below 6.5%, but this threshold remains an important number in the minds of market participants trying to parse between a first tightening in late 2015 or early 2016. The move from 7.0% to 6.7% is equivalent to about 4 months given the pace of improvement in the 12 months prior to this report. This degree of variability is significant, regardless of whether it gets revised out in the future.
Meanwhile, just when you thought you had a handle on tapering, JPM says the latest employment report should cause you to think again:
The December jobs report dumped an ugly mix of slowing employment growth and disappointingly-low labor supply on policy makers. The December FOMC meeting minutes recount an active debate on labor conditions between Committee participants, with several noting the continuing elements of cyclical weakness and labor market slack. The December data will add fuel to that debate, although we think the FOMC will need to see a more sustained shift in trend before it changes trajectory on the pace of tapering. For now, we continue to expect the Fed to cut purchases at the pace of $10bn per meeting, including its upcoming January 29 meeting.
Looking ahead, JPM says it expects rates to stay range-bound over the near term and remains tactically neutral on duration.
The ten-year Treasury yield has crept a bit higher, to 3.008% from 2.999%, after the Federal Reserve released the minutes of its December policy committee meeting – you know, the one where the Fed finally pulled the trigger on tapering. Here are some key parts that focus on the tapering discussion:
Regarding the marginal efficacy of the purchase program, most participants viewed the program as continuing to support accommodative financial conditions, with a number of them pointing to the importance of purchases in serving to enhance the credibility of the Committee's forward guidance about the target federal funds rate. A majority of participants judged that the marginal efficacy of purchases was likely declining as purchases continue, although some noted the difficulty inherent in making such an assessment. A couple of participants thought that the marginal efficacy of the program was not declining, as evidenced by the substantial effects in financial markets in recent months of news about the likely path of purchases….
[M]ost members agreed that the cumulative improvement in labor market conditions and the likelihood that the improvement would be sustained indicated that the Committee could appropriately begin to slow the pace of its asset purchases at this meeting….
While deciding to modestly reduce its pace of purchases, the Committee emphasized that its holdings of longer-term securities were sizable and would still be increasing, which would promote a stronger economic recovery by maintaining downward pressure on longer-term interest rates, supporting mortgage markets, and helping to make broader financial conditions more accommodative.
The minutes added that "a few members" of the policy committee "suggested that lowering the unemployment threshold to 6 percent could effectively convey the Committee's intention to keep the target federal funds rate low for an extended period. However, most members wanted to make no change to the threshold and instead preferred to provide qualitative guidance to clarify that a range of labor market indicators would be used when assessing the appropriate stance of policy once the threshold had been crossed."
The U.S. Treasury market was mixed in late morning market action, with the price for the 10-year note rebounding from earlier losses and rising for the first time in three days.
The Commerce Department reported that the U.S. GDP expanded at its fastest pace in two years during the third quarter owing to a push from stronger consumer spending.
That data helped fuel sentiment that the economic recovery is accelerating, a notion that led the Federal Reserve to announce Wednesday plans to taper its $85 billion-a-month bond-buying program in January. The central bank is also keeping short-term interest rates at current low levels until the unemployment rate drops well below its 6.5% target.
The 10-year Treasury bond yield, which falls as prices rise, dropped two basis points to 2.91%, having earlier risen to 2.94%. The 30-year bond-yield fell roughly six basis points to 3.86%
But intermediary debt continued to underperformed longer maturities. The five-year bond yield, which is vulnerable to shifts in monetary policy, climbed roughly four basis points to 1.676%, while the two-year note yield rose one basis point to 0.378%.
Adrian Miller, director of fixed-income strategy for GMP Securities wrote:
The weakness of the short end [of the curve] comes despite great effort on the part of the Fed to relay an aggressive message that short term rates (Fed Funds) will remain anchored for a considerable period of time. And yet, after the market had a chance to think about what Chairman Bernanke had to say at his press conference coupled with the opinions of the FOMC members on when the first rate hike may happen as reflected in the SEP, it seems there is a growing consensus that the first hike in the FF may comes somewhat earlier than expected. Hence, we are seeing the short end of the curve underperform since mid-day on Thursday.
U.S. Treasury prices remained weak, sending yields higher, Thursday afternoon as investor appetite for new U.S. government debt was weighed down by the Federal Reserve's decision yesterday to start trimming its bond-buying program.
The 10-year bond yield rose following a $16 billion TIPS sale and a $29 billion auction of seven-year notes. But it was intermediary debt that took the brunt of the punishment.
Adrian Miller, director of fixed-income strategy for GMP Securities, writes:
We got a muted reaction yesterday after the Fed made its tape announcement. Today, investors have come to realize that the process of tapering from $85 billion in monthly bond purchases to nothing will not be a straight forward endeavor. It will face significant challenges.
The 10-year bond yield climbed three basis points to 2.934% after earlier climbing above 2.95%. The price on the 30-year note, however, rose, sending the yield down one basis point to 3.9%
The five-year bond yield sat at 1.65% after earlier rising to roughly 1.68%. The seven-year bond yield climbed six basis points to 2.33%, which put it on track to close at its highest yield since September.
And the two-year bond got hammered the hardest. The yield climbed three basis to 0.374%.
"That's a 10% increase in yield vs the 1% increase in the yield for the 10-year note…That flattening between the two- and 10-year is unexpected given the Fed's forward guidance emphasis last night," says GMP's Miller.
After a two-day policy meeting, the Fed ended months of discussion and speculation when it unveiled plans to trim $10 billion off the current $ 85 billion-a-month bond-buying program.
Fed Chairman Ben Bernanke said he expects the bond-buying program to taper steadily through next year and conclude by year end, assuming the economy remains healthy.
The Fed, meanwhile, downgraded its projections for inflation for the next few years. Also, the central bank doesn't expect to hike short-term interest rates before 2015.
In a world of exceptionally low interest rates, investors are hungry for income. Barrons.com's Income Investing blog, written by Michael Aneiro, helps readers find undervalued securities that offer attractive yields, with an emphasis on dividend-paying stocks, preferred shares, bonds, REITs, Master Limited Partnerships and closed-end funds. Prior to joining Barron's, Michael spent five years as a reporter covering credit markets for Dow Jones Newswires and the Wall Street Journal. He holds a master's degree in financial journalism from New York University.


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Gallery: More travel sketches from BBC's Tim Baynes
We wrote yesterday about Tim Baynes' delightful travel sketches from around the world on BBC and liked them so much we came back for more. You can (and should!) get lost for hours looking at his drawings on Flickr with fun anecdotes and scribbles bringing depth and humor to his slice-of-life artwork.
Check out some of our favorites in the gallery below, from a look inside the BBC Starbucks to the madness of Dubai immigration during the ash cloud to a quiet barbershop in Tripoli.
See more of Tim Baynes' work on the BBC, his personal Flickr stream, or order a copy of his book Doors to Automatic and Cross Check, direct from the artist.
All photos courtesy of Tim Baynes.
Filed under: Photos, Africa, Asia, Europe, North America, Libya, Tunisia, Japan, Turkey, United Arab, France, Ukraine, United Kingdom, Canada, United States, Middle East, Hong Kong


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Enlarge Image The DiamondBack HD Truck Cover protects equipment, opens at both ends to provide full bed access, and, most importantly, creates a 1600 lb hauling platform on the bed rails of your truck. Easily installed atop the bed rails on your pick-up truck, the Diamondback HD center panel clamps to each bed rail. Front & rear panels secure to the center panel on heavy-duty hinges and quick release gas shocks. Each panel is made from .100" thick 3003 alloy aluminum tread plate for a sturdy traction surface with stainless external hardware and zinc-plated steel internal hardware. Transport up to 1600 lbs on top of the DiamondBack HD Truck Cover and secure it using the tie down cleats that surround the outside. 2 keyed self-closing T Locks ensure your cargo stays safe inside the truck cover and the flip top cover keeps water & dust out of the lock. Steel rods lock into the side rails and do not require ANY drilling. The DiamondBack HD keeps cargo dry with full compression seals and center panel gutters that channel water run-off when the panels are open. Protect your rear window with DiamondBack Cab Guards made with quality aluminum that mount to SE or HD truck covers. *May Require Non-Clamp Mounting Method - Including Possible Drilling (see Instructions (.pdf)) DiamondBack HD Truck Covers Product Features:
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