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MUSC Poster Presentations
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A Resident- Powered EBM Training Program
Abstract: Residents in the Department of Pediatrics at the Medical University of South Carolina (MUSC) participate in an intensive program to learn the practice of Evidence-Based Medicine (EBM). This is a unique "redident-powered" program that includes hands-on weekly sessions to answer clinical questions using EBM, formulating and answering EBM questions with a librarian during rounds, and a dedicated group of faculty that serve as team leaders and mentors. In their last years, residents create their own evidence by doing a capstone research project.
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MEDICA: Capturing Today's Scholarship; Preserving Tomorrow's History; Opening Access to MUSC
In 2008, MUSC Library and Waring Historical Library joined as a partner in the Low Country Digital Library, a project at the College of Charleston and part of the larger South Carolina Digital Library. Statewide partners include Clemson, USC, College of Charleston, and dozens of smaller South Carolina institutions. MEDICA is powered by ContentDM, a content management system robust enough to accept and display a huge variety of file formats, including video, audio, PowerPoint, and more. MEDICA staff work in concert to recruit new scholarship for the IR and to digitize historical materials from the Waring Historical Library.
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Clinical Portals & WebCT
Librarians support clinical and educational missions of medical centers through their availability to assist with the acquisition of information and materials on an "as reported" basis. We sought to integrate the librarian more fully into clinical care and clinical education in a teriary children's hospital. We began with three clinical divisions, each with unique needs, and developed a system of web-based materials that can be managed to deliver patient information to specific groups of people.
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History in the Making: Building an Institutional Repository and Digital Archive From the Ground Up
MEDICA MUSC Electronic Documents Initiative and Collected Archives. Introduction: The Process: The academic health science library at the Medical University of South Carolina (MUSC) has formed a partnership with the Waring Historical Library (WHL), also at MUSC, to create MEDICA, the MUSC Electronic Documents Initiative and Collected Archives. The WHL began pursuing digitization as a means to preserve material and expose their unique collection to a wider audience. The MUSC Library found that the Waring's efforts provided an opportunity to launch an institutional repository that will showcase faculty and student scholarship. This poster will present the concept and process for implementation for MEDICA.
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High Glucose Enhances Fibroblast-Macrophage Coculture-Boosted MMP-1 Expression
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Crosstalk Between Adipocytes and Mononuclear Cells Stimulates Osteopontin Expression via IL -6 and IL -1b
Poster presentation. Abstract: Although it is known that macrophage content in visceral adipose tissue is significantly increased in obese humans and mice, the crosstalk between macrophages and adipocytes and its impact on the expression of genes involved in inflammation that contributes to insulin resistance have not been well elucidated. In this study, we incubated human monocytes, macrophages, or U937 mononuclear cells with adipocytes in a transwell system and studied how cell interaction regulated the expression of osteopontin, a matrix glycoprotein and proinflammatory cytokine that mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance. Results showed that coculture of human monocytes, macrophages or U937 cells with adipocytes led to a 3- to 5-fold increase in osteopontin production when compared to that released by independent cultures of monocytes, macrophages or U937 cells and adipocytes. Moreover, LPS or palmitic acid, which activates Toll-like receptor (TLR)4, and high glucose augmented the coculture-stimulated osteopontin secretion. Real-time PCR studies showed that coculture of U937 cells and adipocytes led to increased osteopontin mRNA in U937 cells, but not adipocytes, suggesting that adipocyte-derived soluble factors may stimulate osteopontin expression in U937 cells. This notion was supported by the observation that osteopontin expression by U937 cells was increased by 2-fold by treatment with adipocyte-conditioned medium. In our studies to explore the mechanism involved in the coculture-stimulated osteopontin expression, we found that the neutralizing antibodies against IL-6 and IL-1b, but not those against IL-1a and TNFa, effectively blocked coculture-augmented osteopontin expression, indicating that IL-6 and IL-1b may stimulate osteopontin expression in the coculture. In support of this finding, experiments showed that IL-6 and IL-1b stimulated osteopontin expression. In conclusion, this study demonstrated that the crosstalk between adipocytes and U937 cells stimulated osteopontin expression via IL-6 and IL-1b and that TLR4 activation and high glucose further enhanced the adipocyte/U937 cell interaction-stimulated osteopontin expression.
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Lactate Boosts TLR4 Signaling and NF?B Pathway-Mediated Gene Transcription in Macrophages via Monocarboxylate Tr ansporters and MD-2 Upregulation
Poster presentation. Abstract: It has been shown that lactate induces insulin resistance. However, the underlying mechanismshave not been well understood. Based on our observation that lactate augments lipopolysccharide (LPS)-stimulated inflammatory gene expression, we proposed that lactate may enhance Toll-like receptor 4 (TLR4) signaling in macrophages, which has been shown to play an important role in insulin resistance in adipocytes. In this study, we demonstrated that lactate stimulated MD-2, a co-receptor for TLR4 signaling activation, NF?B transcriptional activity, and the expression of inflammatory genes by human U937 macrophages. Similar enhancement of the inflammatory gene expression by lactate was also observed in human monocyte-derived macrophages. The essential role of MD-2 in lactate-augmented TLR4 signaling was confirmed by observation that the suppression of MD-2 expression by small interference RNA (siRNA) led to significant inhibition of inflammatory gene expression. To further elucidate how lactate treatment enhances TLR4 activation, we showed that the augmentation of inflammatory gene expression by lactate was abrogated by antioxidant treatment, suggesting a critical role of reactive oxygen species (ROS) in the enhancement of TLR4 activation by lactate. Finally, we showed that ?-cyano-4-hydroxycinnamatic acid (?-CHCA), a classic inhibitor for monocarboxylate transporters (MCTs), blocked lactate-augmented inflammatory gene expression and nuclear NF?B activity. Taken together, this study has documented that lactate boosts TLR4 activation and NF?B-dependent inflammatory gene expression via monocarboxylate transporters and MD-2 upregulation.
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Poster presentation. Abstract: It has been shown that the innate immune system plays an important role in the pathogenesis of diabetes. However, the effects of diabetes on the innate immunity have not been well understood. CD14, a receptor for lipopolysaccharide (LPS) and one of the pattern recognition receptors (PRRs), plays an essential role in the innate immune responses. Although clinical studies have shown that CD14 expression in monocytes from diabetic patients is higher than that from nondiabetic individuals, the underlying mechanism has not been defined. In the present study, we determined the effect of elevated concentration of glucose on CD14 expression by U937 mononuclear cells. Real-time PCR showed that high glucose augmented LPS-stimulated CD14 expression by 15-fold as compared with normal glucose. Immunoassay showed a marked enhancement of both membrane-associated and soluble CD14 levels by high glucose. Further investigations revealed that high glucose augmented LPS-stimulated CD14 expression by enhancing NF?B and AP-1 activities. Finally, studies showed that augmentation of LPS-stimulated MMP-1 expression by high glucose was inhibited by anti-CD14 antibodies, suggesting a crucial role of CD14 in high glucose-enhanced gene expression. Taken together, this study has demonstrated a robust augmentation by high glucose of LPS-stimulated CD14 expression, suggesting that hyperglycemia may enhance the innate immunity.
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Simvastatin Suppresses LPS-Induced MMP -1 Express ion in U937 Mononuclear Cells by Inhibiting Protein Isoprenylation-mediated ER K Activation
Poster presentation. Abstract: Matrix metalloproteinase (MMP) plays a crucial role in vascular diseases and inflammatory mediator lipopolysaccharide (LPS) is a powerful stimulator of MMP expression. Thus, researchers have long sought to discover agents that are potent in inhibiting LPS-stimulated proinflammatory gene expression and useful to treat vascular diseases. In this study, we demonstrated that simvastatin, a 3-hydroxyl-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, effectively inhibited LPS-stimulated MMP-1 as well as MMP-8 and MMP-9 expression by U937 mononuclear cells. Furthermore, results showed that geranylgeranyl transferase inhibitor (GGTI) inhibited LPS-stimulated MMP-1 expression and addition of isoprenoid intermediate geranylgeranyl pyrophosphate (GGPP) diminished the inhibitory effect of simvastatin on LPS-stimulated MMP-1 expression. Results also showed that simvastatin inhibited the membrane association of Ras and Rac and the inhibition was abolished by addition of GGPP. In addition, inhibition of Ras and Rac isoprenylation by Ras and Rac inhibitors led to inhibition of MMP-1 expression. These results indicate that Ras and Rac protein isoprenylation is targeted by simvastatin in the inhibition of LPS-stimulated MMP-1 expression. Moreover, we showed that simvastatin inhibited LPS-stimulated nuclear transcription factor AP-1, but not NFkB activity, and the inhibition was reversed by addition of GGPP. Simvastatin also inhibited LPS-stimulated extracellular signal-regulated kinase (ERK), but not p38 mitogen-activated protein kinase (MAPK) and Jun N-terminal kinase (JNK). Finally, we showed that the inhibitory effect of simvastatin on LPS-stimulated ERK activation was significantly reduced by addition of GGPP. Taken together, this study showed that simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by targeting Ras and Rac protein isoprenylation-mediated ERK activation.
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High Glucose and Interleukin 6 Synergistically Stimulate Matrix Metalloproteinase-1 Expression by U937 Mononuclear Cells through c-Jun Upregulation and ERK and JNK Cascades
Poster presentation. Abstract: Matrix metalloproteinases (MMPs) play a crucial role in the destabilization of atherosclerotic plaques that may lead to plaque rupture-triggered acute coronary syndrome. Although it is known that interleukin 6 (IL-6) is associated with atherosclerosis, and diabetes increases acute coronary events, the regulation of MMP expression in mononuclear cells by IL-6 and the impact of high glucose on the regulation have not been well documented. In the present study, we found that IL-6 stimulated MMP-1 expression in a concentration- and time-dependent manner in U937 mononuclear cells and high glucose further increased IL-6-stimulated MMP-1 expression by 2-fold. By comparing the stimulatory effect of IL-6 with that of lipopolysaccharide (LPS) on MMP-1 expression, we found that IL-6 was 3-fold more effective than LPS at 1 and 10 ng/ml, suggesting that IL-6 is a potent stimulator on MMP-1 expression by U937 cells. Furthermore, results showed that high glucose, IL-6 and LPS stimulated MMP-1 expression by 1.4-, 3.9-, 6.1-fold, respectively, after 24 h treatment, but the combination of high glucose, IL-6 and LPS led to a 53.3-fold increase, revealing a remarkable synergistic effect between high glucose, IL-6, and LPS on MMP-1 expression. In the studies to elucidate how high glucose and IL-6 act synergistically for MMP-1 upregulation, we found that while either high glucose or IL-6 increased c-Jun expression by 2.5-fold, the combination of high glucose and IL-6 stimulated c-Jun expression by 5-fold. In contrast, high glucose did not enhance IL-6-stimulated c-Fos expression. These results suggest that high glucose and IL-6 exert synergy on MMP-1 expression by upregulating c-Jun, an immediate early gene and a major subunit for transcription factor AP-1 that is known to play a key role in MMP-1 transcription. Our further studies showed that the extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) pathways, but not Janus kinases /signal transducer and activator of transcription (JAK/STAT)3 cascade, were involved in high glucose and IL-6-stimulated MMP-1 expression. Taken together, this study showed that high glucose and IL-6 synergistically stimulate MMP-1 expression in U937 mononuclear cells through c-Jun and ERK and JNK cascades.
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A Trend of Increase in Periodontal IL-6 Expression across Patients with neither Diabetes nor Periodontal Disease, Patients with Periodontal Disease alone, and Patients with both Diseases
Poster presentation. Abstract: Objectives: Epidemiological studies have established that patients with diabetes have increased prevalence and severity of periodontal disease. However, the periodontal expression of inflammatory cytokines and matrix metalloproteinases (MMPs) in diabetic patients has not been well characterized. The objective of this study is to determine the difference in the periodontal expression of MMP-1, MMP-8, interleukin-6 (IL-6), tumor necrosis factor (TNF) alpha and IL-1 beta between diabetic and nondiabetic patients. Methods: Periodontal tissue specimens were collected from 9 non-diabetic patients without periodontal disease (group 1), 11 non-diabetic patients with periodontal disease (group 2) and 7 diabetic patients with periodontal disease (group 3). The expression of MMP-1, MMP-8, IL-6, TNF alpha and IL-1 beta was quantified using real-time PCR. Results: The nonparametric Kruskal-Wallis test showed that the difference in IL-6 expression among the groups was statistically significant (p = 0.04). Furthermore, the generalized Kruskal-Wallis nonparametric linear-by-linear association test showed a statistically significant trend of increase in the expression of IL-6 from group 1 to group 2 to group 3 (p=0.02) and a suggestion of such a trend in MMP-1 (p=0.05). No increase in MMP-8 expression was observed in patients in group 3 as compared to patients in groups 1 and 2. Although the average expression levels of MMP-1, IL-1 beta, and TNF alpha were increased from group 1 to group 3, the differences were not statistically significant. Conclusion: A trend with increased IL-6 expression in periodontal tissues was observed across patients with neither diabetes nor periodontal disease, patients with periodontal disease alone, and patients with both diseases.
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Pharmacologic Sphingosine Kinase Inhibition with ABC294640 Prevents Proteinuria and Improves Survival In the MRL/lpr Murine Model of Lupus
Poster presentation. Abstract: Purpose. Sphingosine kinases (SKs) phosphorylate sphingosine to create sphingosine 1 phosphate (S1P), which is involved in cell survival, proliferation, motility, and inflammation via intracellular signaling through release of Ca2+ stores, activation of NF??B, and extracellular interactions with G protein-coupled receptors (S1P receptors 1-5). Inhibitors of SK1 have been used successfully to treat experimental murine inflammatory bowel disease, diabetic retinopathy, and rheumatoid arthritis. SK1 is expressed in mesangial cells and plays a role in mesangial cell migration. The role of SKs in promoting inflammation in lupus is unknown. We hypothesized that ABC294640 (ABC), an orally available SK inhibitor, would reduce markers of glomerular pathology in the MRL/MpJTnfrsf6lpr/ J (MRL/lpr) murine model of lupus. Methods. Eleven MRL/lpr mice were treated with either polyethylene glycol (PEG, n=5) or ABC in PEG (50 mg/kg/day, n=6) from 10 (before onset of disease) to 20 weeks of age (significant albuminuria present). Urine was collected every other week and analyzed for albumin. Moribund mice were sacrificed, and all measures were carried forward. At 20 weeks, kidney and total weights were determined. Renal, skin, and joint tissue were harvested for histopathological scoring, while renal tissue was stained for IgG/C3 deposition and examined by electron microscopy. Serum anti-double stranded DNA antibody levels were determined at 20 weeks. Urine thromboxane levels were determined at 16 weeks. Spleen cell subsets were determine by flow cytometry. Differences between groups were determined by t-test or Wilcoxon rank sum analysis. Results were reported as averages standard error. Results. Survival was greater in ABC-treated mice than controls (100 vs. 40% at 20 weeks). By 18 and 20 weeks, proteinuria was lower in ABC-treated mice than control mice (106 vs. 3818 and 191 vs. 6021). Kidney/total body weights were significantly lower in ABC-treated mice than controls (1.50.1 vs. 2.20.1 mg/g, p=0.001). There was a trend towards lower renal thromboxane production in treated mice. Renal and cutaneous pathologic scores were lower in treated mice. Neither anti-double stranded DNA antibody production nor basement membrane and mesangial IgG/C3 staining were different between groups. Spleen marginal zone B cells were greater in treated mice. Conclusions. ABC294640 treatment improves survival, possibly due to reduced renal failure and vasculitis. ABC294640 treatment reduces often clinically refractory necrotic/crescentic glomerular lesions associated with reduced renal function in humans, making SK an attractive target for investigation as adjunctive therapy ABC294640 treatment reduces podocyte flattening associated with nephrotic range proteinuria in humans, making SK a possible target for investigation as adjunctive therapy in membranous nephritis with nephrotic range proteinuria. Improvements in outcomes are independent of changes in production and deposition of nephritic autoantibodies. We hypothesize that inhibition of SK may reduce homing of inflammatory cells and activation of resident and inflammatory cells to produce inflammatory mediators such as thromboxane.
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High Glucose and Interferon Gamma Stimulate Matrix Metalloproteinase-1 Expression in U937 Mononuclear Cells by Upregulating MD -2 and AP -1
Poster presentation. Abstract:We have reported that high glucose and IFN? synergistically stimulate matrix metalloproteinase (MMP)-1, a proteinase involved in diabetic complications, by U937 mononuclear cells. We also reported that pre-exposure to high glucose and IFN? markedly increased lipopolysaccharide (LPS)-stimulated MMP-1 expression. To understand how high glucose and IFN? augment MMP-1 expression, we analyzed their effect on the expression of IFN? receptor, Toll-like receptor (TLR)4, CD14, and MD-2, a protein associated with TLR4 and conferring LPS responsiveness. Results showed that high glucose and IFN? had no effect on the expression of IFN? receptor, TLR4, and CD14, but stimulated MD-2. IFN? alone stimulated MD-2 expression by 3.4-fold (0.49 vs 0.15, MD-2/GAPDH mRNA) and high glucose alone had no significant stimulation. Interestingly, the combination of high glucose and IFN? further increased MD-2 expression by 1.7-fold as compared to the combination of normal glucose and IFN? (0.85 vs 0.49, p<0.01). These data indicate that MD-2 expression is specifically upregulated by high glucose and IFN?. More interestingly, we found that neutralizing antibody to MD-2 blocked high glucose and IFN?-stimulated MMP-1 expression. The antibody at 2.5 ?g/ml had 70% blocking while control antibody did not have significant effect. Since it is known that transcription factor AP-1 plays a crucial role in MMP-1 expression, we further determined the effect of high glucose and IFN? on the expression of c-Jun and c-Fos, two major subunits for AP-1. Results showed that high glucose and IFN? increased c-Jun expression by 1.8- and 2.1-fold, respectively, but high glucose plus IFN? increased c-Jun expression by 5.2-fold. Similarly, high glucose and IFN?increased c-Fos expression by 2.3- and 1.4-fold, respectively, but high glucose plus IFN? increased c-Fos expression by 3.6-fold. In conclusion, this study demonstrated that high glucose and IFN? stimulate MMP-1 expression in U937 cells by upregulating MD-2 and AP-1 expression.
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Library > Computers & the Internet > Programming
2003A Look at Logo: MicroWorlds Pro has dedicated its text to explaining the complicated process of MicroWorlds Pro. MicroWorlds Pro has been a project at our school ever since our fourth grade teacher moved down to the tech lab, and we wanted to share our project with the world. We have included teachers' lesson plans, activities for students, and information about real turtles for animal lovers. About this site
2003Blueprint offers different types of web design tutorials including HTML, JavaScript, Photoshop, and Flash. We have everything you may need for creating websites.About this site
2003Here you will learn about System Dynamics and how it impacts the world around us. This field is becoming increasingly important and can have vast influences on how our society works. By knowing and understanding systems, we will be able to make predictions using models of the systems. These models can be an accurate way to predict how the system will act over a long period of time.About this site
1998With the help of a very smart turtle you can learn Logo, a computer language. Learn about loops, parameters, and stars as you learn to draw with a computer. A special guide for teachers instructs them on using the lessons in a classroom setting. Once you have learned to use Logo, enter the online contest and show off your knowledge. This site is in English, German and French. About this site
2009The Cyber Crime site provides extensive explanations of what is meant by the computer terms: viruses, trojans, worms, spam, black hat crackers, grey hat hackers, and white hat hackers.About this site
2007It's a User Friendly Web site that teaches Techniques about Photoshop, Fireworks, and it also gives u a Variety of brushes and fonts to help on any project of your own.About this site
2006Explore the amazing world of HyperText Markup Language (HTML). Learn how to make a simple web page or look up simple tags that you may have forgotten.About this site
2006Welcome to the world of Open source, where software, licenses, and ideas are all free to move and evolve in any community in any language and in any place in the world.About this site
2004Our team is a small and consists from three boys. We all are from gymnasuim #1 in a town Volkovysk in Belarus. Our favourite subject is Computer Science. We like to draw by computer and we have begun to learn 3DMax program. We have had many problems during our learning. That is why we decided to create a web-page about the first steps in this diffAbout this site
2004This page will have beginner lessons on how to use POV Ray for graphics and how to use the pictures you create for different projects.About this site
2003This page is dedicated to the BASIC Programming language, more specifically the Microsoft QuickBASIC, or QB, Compiler/Interpereter. About this site
2003Welcome to our website about how to make a website. It teaches basic html, tablework, and some basic framework. There's a menu on the left that tells you where everything is. Everything is split into sections. I hope you find our website helpful... About this site
2003Learn about Java from students of the Oracle Internet Academy at Lower East Side Prep High School in New York City.About this site
2003We are a dedicated website that tries to promote the making of 3D Animated Movies and Clips. Well, we at Techno3D know that it is hard to learn 3D, but with these basic procedures and steps, you can learn how to make a landscape scene in Bryce 5 or how to make a human talk in Poser 4. All of these things are possible just by visiting our website. About this site
2003This HTML guide is a step-by-step informative guide. So, even if you know some html, a lot, or none at at all, this guide is for you!About this site
2001HTML 4 Anyone is dedicated to helping students learn the Hypertext Markup Language used for web page development. You can start off eay, with how to place text, links, or backgrounds on your pages or you can learn advanced HTML like ASP and hover links. Our color index gives you an array of good colors to use on your pages. We test your memory on how to write code.About this site
2000This page containes the descriptions of some of the most used algorithms for file compression.About this site
2000Our web site, Math, Programming, and Beyond is for people who want to learn and want to use their math and programming skills to achieve a goal. Visitors who enter the site are immediately a part of an expedition to gather an important metal from a planet. Their ship is sabotaged, the information manual is damaged, and astronauts must learn new skills in order to survive and save their fleet. Our web site is split into two sections: math and Visual Basic programming. If visitors are successful and acquire some of the skills in these sections, they can advance to the rest of the simulation. They have a choice between a short simulation and a long simulation. They can also choose to just view the pages and take some quizzes. About this site
2000Object Programming Center is a web page for everyone who wants to find information about object programming for Windows. About this site
2000Programming and Electronics Network demonstrates visual Basic and Borland visual languages.About this site
2000The goal of the Reyes-Andres Network is to provide all Internet users visiting the website an opportunity to learn more about the background of computers. The Reyes-Andres Network also features tutorials and free programs for graphing calculators for use in mathematics and science classes. In addition, submitted as an Interdisiplinary website to the ThinkQuest Internet Challenge, the Reyes-Andres Network includes original poetry and downloadable electronic books which visitors may view for both educational and enjoyable purposes.About this site
1999The creators of "Ad Infinitum Web: The Art and Science of Supercharging the Web" hope to achieve what few sites offering web design information have. There are informative tutorials and lessons on the programming languages needed for web construction proficiency: HTML, Perl CGI, C++ Programming, and SSI. About this site
1999 Welcome to "Algorithms Alive!". You will find some information about algorithms from this site. We hope those information is useful for you. Those information we did is about basic or simple data structure and searching and sorting algorithms. At that moment, we must apologize to all of you... Since algorithms is quite a large and difficult topic for us, actually, we don't have enough time and knowledge and also, experience .. About this site
1999Creation: The Teaching of HTML is a website designed to teach the basic user how to code HTML. It presents a basic and slightly advanced view on how to write HTML. It also features a CGI-scripted glossary for easy lookup of HTML tags and descriptions.About this site
1999The Guide to Learning HTML is a HTML tutorial. On this site, we attempt to give both students and teachers a better understanding of HTML. We hope you will find this site educational, enjoyable, and easy to use.About this site
1999Our entry provides a complete guide to HTML and introduction to Java scripts and DHTML. We use friendly tone, humor, and informal language to capture and keep the reader's attention. This site is especially made for beginners, but is also helpful as a reference for amateurs and experts. We provide a chart with all the HTML tags, their attributes and functions. All tags are accompanied by examples.About this site
1999Learn CGI Programming with Perl is intended to teach users how to program in the Perl programming language through CGI. Perl is a very important tool to have these days, as a vast majority of the Internet's functionality is based on it. It is assumed that the user would have no prior programming experience. The 'curriculum' is taught in a series of lessons that have plenty of examples in order to ease the learning process. Our piece de resistance is a web-based Perl interpreter where users can write their own perl, to try out what they have learned, right from a form on our website. Helping garner a community and collaborativity spirit is our message board, where users of the site can collaborate with each other. The main function is to ask and answer questions related to perl, in essence creating a growing knowledge base/FAQ over time.About this site
1999Our site is mainly aimed at people wanting to get a start in programming. It takes the user through a series of lessons. After the user has completed reading all the lessons we have some practical exercises for them to do. As well as an interactive pascal quiz. There is also a message forum and a mailing list that people can join on our site to share their ideas with other people from around the world.About this site
1999Programmer's Cafe web site teaches students programming using Pascal. There are a lot of places on the ne, where you can learn programming. Our site is special, because it lets you learn programming in an easy way. Just grab a cup of coffe and enjoy our Cafe. Pascal section covers basic language specifications and algorythms. Each student or teacher will be able to create their own lessons to expand the server and collaborate with other. Discussion group is available to help students share their ideas and opinions. In future, we plan to enlarge the site with test taking and on-line judging capabilities. Let us know your ideas on making it better.About this site
1999This site learns you all ins and outs of Aritificial intelligence. But not in the old-fashiond way. This site doesn't tell boring, historical stories. You won't learn all about peoples lives. You will take a look at AI programs from the inside! At the end of this course you can make your own AI programs. No programming experience requird! Also in DutchAbout this site
1999Our website was created to teach the general public (of just about any age) a simple, quick, DOS based programming language called QBasic. We are going over the topics of: describing what QBasic is, how to open it, and many levels of programming within it.About this site
1999This is a web page designed to teach the basics of programming in the Visual Basic programming language.About this site
1998Perl and CGI are extensions of HTML, that cool language that makes web pages possible. This is an extraordinary site for advanced computer students on how to use Perl and CGI to extend the capabilities of web pages. Students are able to read through a FAQ section, learn through lessons, and put their knowledge to the test in the Testing Area. About this site
1998Learn how to create your own computer graphics by learning advanced graphics programming. Languages such as C/C++ and Pascal are introduced. Learn the three basic commands for assembly, about transitions, and 3-D. Use the Java Chat Room, e-mail, or the weboard to communicate with this team and learn more. This site will be most useful to those already skilled in programming. Not for newbies. About this site
1998All the tools needed to become a successful webmaster are available at your fingertips through the services of this site.The tutorials are useful for beginners, or as refresher courses for more experienced programmers. Visit the "Code Center" to download or view Java Applets, Javascript code, CGIs, and ActiveX Scripts. About this site
1998Discover every aspect of computer operation. Take the course in beginning programming, using Pascal. Or you might want to learn about C or Assembly language, because there are tutorials here for those as well. Learn about how to connect your computer to an Internet Service Provider (ISP), and navigate the Internet. Finally, you can see how to build your own computer, using component parts and a lot of patience. About this site
1998Want to learn to write web pages? Then this is the site for you! Whether you are a beginner or advanced student you will find something here to help you. This entry provides a history of HTML as an introduction to the language. Learn how to use fonts and colors, align text, create links, and insert images. Once you learn how to create your own web page, you can even find free web space in the links section. About this site
1998QBasic is a computer programming language. This web site is designed to teach the novice computer programmer how to use it. The site is divided into three modules that each contain lessons on basics, graph skills, and the future of Qbasic. Complete assignments at the end of every lesson to check your understanding of the information. This is a great starting point for future programmers, QBasic concepts can later be applied to more involved languages. About this site
1998Learn to program computers by mastering Pascal. Serious students of computer programming will find a wealth of useful information here. This well-designed site provides online "courses" in using the Pascal language, and includes separate instructions for the beginning, intermediate, and advanced programmer. Also featured are useful "real world" tips for successful programming and a glossary for figuring out the sometimes confusing terminology. About this site
1998You're making a web site, but you want to add some cool things: games, moving words, a counter, a calculator, or maybe a chat room. How do you get those on your web site? You use something called a script. It might be Java, CGI, or HTML. It's a series of commands you write, so a browser can display special features. Not a great programmer? You don't have to be. Get them all here. About this site
1998This site offers a tutorial on building your own web page with HTML. You will find a step-by-step exercise that de-mystifies the terminology involved as it teaches. Figure out how to use CGI and then try your hand at Java applets. There's also a blueprint for designing your site and making wise graphic decisions. About this site
1998Everyone needs his or her own web page! And here is an excellent resource for high school students interested in learning how to create one. Broken down into Beginner, Intermediate, and Advanced lessons, each section has lectures on different topics, offering explanations and showing examples. Lecture topics include: HTML, Images, Text, Entities, tables, Graphics, and Javascript. There is also a helpful set of links pertaining to javascript and Photoshop. About this site
1998What's your favorite HTML tag? What, you mean you don't have one? You say you don't know a thing about HTML but want to learn how to make your own web page? Look no further. This page tells you what to do, helps you experiment, and even gives you your own web space so you can build web empires of your own. About this site
1998Creating a web page does indeed look like magic to a novice. This is a step-by-step tutorial to web page design. There are lots of links to software manufacturers, providers of free web space, and tutorials on various aspects of web page design. There's a thorough explanation of the terms and abbreviations used as well as the meaning of the different icons used in various computer programs. About this site
1998WebWorks is the premier resource for the neophyte web programmer. This is the place to go to learn HTML, the language of the web. Once you learn HTML, you can advance to learning other web page enhancements such as Java and CGI. This is an excellent tutorial for all levels. About this site
1998This web site will teach you about the programming language Logo, and how it's used to draw spirals, wheels, and fractals. The "philosophy" of each shape is presented along with models. Once you read about the creation of each shape you may want to try the Logo language yourself! The bibliography includes traditional and electronic sources. About this site
1997If you want to gain experience with computer graphics without having to buy expensive software, try this site for some ideas. Here you can learn about two-dimensional effects such as blurring and waves, and three-dimensional effects such as perspective, shading, and "alpha blending." This site contains an excellent explanation of terms, as well as tutorials, tips and tricks, and links to other graphics sites. About this site
1997Do the terms "hypertext markup language," "Java," and "CGI script" sound mind-boggling to you? This site explains these terms so that anyone can learn to use them. Complete tutorials on how to utilize these protocols to design web pages and add interactivity are provided. Also available is a huge list of links to other sites with information to further your web-building skills. About this site
1997If you're looking for an easy yet comprehensive guide to HTML, look no further. For both the new users and the more experienced ones, this site provides a complete guide to web editing using HTML. Easy navigation makes this site ideal as an online tutorial. Learn an HTML tag, then a simple click shows you what it will look like from the browser. Links connect you with more HTML tutorials. About this site
1997It's not about coffee, but this site will tell you all about Java: a flexible programming language with a lot of possibilities. Learn basic Java terminology and structure, see some cool applet examples, create your own simple applet, and learn more about Java by following the links to other sites. About this site
1997Keyframing is a way of representing the movement of on object through space. It is a basic technique for computer animation. On this site you will learn what you need to know to get started on your own animation projects. Downloadable files are available, and helpful links take you to further information. Not all sections of this tutorial are working. About this site
1997This web site teaches the novice user to program computers using the Pascal language. Three skill levels provide instruction for various levels of understanding. A six day beginner course introduces what programming is, parts of a program, variables and constants, procedures and functions, and variables. After completing the beginner level you can move on to the more difficult lessons. This offers a good introduction for the novice. About this site
1997A site about programming for video games.About this site
1997Get creative with the computer! This site introduces the world of computer-generated art, and will show you how to put together a basic web page. The introduction to HTML pogramming for beginners covers tags and page layout. More advanced techniques, such as forms and javascript, are also covered. Some examples of computer-generated student images are displayed in the computer art section. About this site
1997This page is designed to introduce others to the wonderful world of 3D graphics. 3D graphics are used in many different aspects of the working world including movies (Star Wars and Toy Story), advertisments, and most often it is used in TV shows. About this site
1997This is a great site to visit if you are planning to create your own Web page. A complete tutorial in page design and HTML will get you on your way. A quiz is offered to test your learning as you go. There is even an HTML editor on which to practice your new skills. A link to Product Reviews is full of useful information about software options for Web designers. About this site
1997This concise introduction to the Internet covers the language of the online world : HTML, VRML Java, and CGI. Start with a history of the Internet and then learn about web style: what makes a web page readable, interactive, and worth looking at. The impressive selection of links take you to some of the leaders in web tool development. About this site
1996Advanced students of math and computer science--dig in here. In thirteen lessons you'll cover everything from Boolean algebra to electronic gate notation. Each of the lessons concludes with an interactive quiz to test your knowledge. A few links are provided, and the site uses a simple design to present a complex subject. About this site
1996Can a computer be programmed to compose music you'd want to hear? It's possible, based on the information presented at this site. Explore how music theory, math, and computer science intersect. Follow the tutorial straight through or click on unfamiliar words to branch off into other realms. Not all the javascript demos are working in this highly technical resource. Several books are suggested for further study. About this site


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Gov. Matt Mead touted Wyoming's progress in gaining industrial jobs and increasing savings during the past year, as he delivered his annual State of the State speech Tuesday before the state House and Senate.
A third Colorado state senator facing a possible recall vote tied to new gun restrictions has decided to resign from office.
State Sen. Evie Hudak, a Democrat, supported several controversial firearm restrictions passed in Colorado earlier this year. Two of her fellow Democrats in the state Senate lost their seats -- largely over their support of tightening gun restrictions -- in September recall elections: Sens. John Morse of Colorado Springs and Angela Giron of Pueblo. In a letter announcing her resignation, Hudak referred to several bills she supported in 2013, including a requirement for criminal background checks on all gun sales and a ban against magazines that can store more than 15 rounds of ammunition.* READ MORE
By Marc Caputo
Charlie Crist's career as a Republican was ruined four years ago after he hugged President Barack Obama onstage; now he says it could be his salvation as a Democrat. READ MORE
North Carolina has become the first state to halt new enrollment in a federal nutrition program for low-income women and children during the federal government shutdown as it works to make the most of remaining funding.
The $7 billion Special Supplemental Nutrition Program for Women, Infants and Children—better known as WIC—provides food vouchers, nutrition information and health care referrals through more than 10,000 local agencies, clinics and state health departments. Of the 8.9 million people who received WIC benefits nationwide in the 2011 fiscal year, about 7 million were children and infants, according to the U.S. Department of Agriculture, which funds the program. READ MORE
Transportation officials in the greater Washington, D.C., region are not saying much about how will respond to a protest by truckers who plan on congesting the Capital Beltway Friday through Sunday.
A group known as "Truckers Ride for the Constitution" plans to intentionally clog up the Capital Beltway starting Friday morning to bring attention to a slew of grievances they have with the federal government, including low trucker pay and high gas prices. READ MORE


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ATV Insurance Online
All Terrain Vehicles, better known as ATVs, need to be insured in some states. But even if your state does not require insurance coverage, it is always a good idea to carry insurance to cover the cost of repair or replacement--or the damage you may cause to other people or property.
In some cases, your ATVs can be included in your homeowner's policy, but learn more about ATV insurance to decide if you would be better off setting up a dedicated insurance policy for your ATV.
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We like to think we supply retailers throughout the UK & Europe with whatever the average kid thinks is cool! The slight problem here of course for you the retailer, is knowing exactly what is hot at the moment. Our Current Best Sellers is automatically re-calculated just after midnight each evening to create a list of our hottest sellers over the previous 30 days. The sales from this B2B site, plus the sales from our on the road & telesales teams are all used to calculate our list of Current Best Sellers
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At the moment 1385 ports use BUILD_DEPENDS= ${RUN_DEPENDS} and 450 ports use BUILD_DEPENDS:= ${RUN_DEPENDS}. This patch fixes ports that are currently broken. This is a temporary measure until we organically stop using := or someone(s) spend a lot of time changing all the ports over. Explicit duplication > := > = and this just moves ports one step to the left Approved by: portmgr
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Servers and bandwidth provided byNew York Internet, SuperNews, and RootBSD
13 vulnerabilities affecting 22 ports have been reported in the past 14 days
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Washington Nationals Gear
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You follow MLB news all year long. For a baseball fanatic like you, the season isn't just seven months long – it's a year-round affair! Celebrate the greatest players in MLB with this 2013 All-Star Game Silver-Plated medallion from the Highland Mint. This collectible features a 2013 All-Star Game logo on one side, plus the Mets' home stadium – where the game will be hosted – on the opposite side.
- Limited edition collectible
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GO Locker Bloody Sweet Love Theme, design to GO Launcher EX, is available now!Notice:
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2.Use it with Bloody Sweet Love GO theme, Which is for GO Launcher EX, is perfect!
1. Make sure GO Launcher EX V2.58 or above and GO Locker v1.10 has been installed;
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When common parasites of dogs and cats infect humans, the illness is called toxocariasis (or visceral larva migrans). Toxocariasis usually affects kids under age 10. Especially at risk are those who like to put things in their mouths, or those whose families have pet dogs or cats.
Many kids won't have symptoms, but if they do, they can include fever, cough or wheezing, abdominal pain, enlarged liver or spleen, poor appetite, a rash that sometimes looks like hives, and enlarged lymph nodes ("swollen glands").
Toxocariasis also may affect the eyes, causing decreased vision, swelling around the eyes, or a cross-eyed appearance. Untreated toxocariasis can cause retinal damage and decreased vision.
Most cases go undiagnosed and do not cause problems. Some toxocariasis cases are diagnosed during a routine eye exam or an X-ray study done for some other reason.
Toxocariasis is an infection caused by the larvae of parasitic worms — Toxocara canis and Toxocara cati — that usually live in the intestines of dogs and cats. Eggs from the worms pass into the feces of dogs and cats and can contaminate pet areas around the home where kids play. The eggs can be swallowed by children, especially those who:
After entering the body, the eggs hatch into larvae that penetrate through walls of the digestive tract and may migrate to a child's liver, lungs, eyes, and elsewhere.
Experts in the United States estimate that about 20% of dogs pass Toxocara eggs into their stool. In Great Britain, 24% of soil samples taken from public parks contained the eggs. Toxocariasis cannot be spread from person to person.
To help prevent kids from being exposed to toxocariasis:
A doctor can usually diagnose a case of toxocariasis by physical exam and blood tests. Doctors may not prescribe any medication to treat a child with mild symptoms. Severe toxocariasis involving the lungs, eye, or other important organs may be treated with antiparasitic drugs to kill the larvae. For severe lung toxocariasis, doctors sometimes also prescribe anti-inflammatory drugs.
A child with severe toxocariasis should be given medicine as prescribed by your doctor. Prevent reinfection by deworming your pets and keeping kids away from areas where pets defecate (poop). Remind your kids to wash their hands often during the day, especially after playing with pets.
Call your doctor if your child has any of the symptoms of toxocariasis, including:
Reviewed by: Joel Klein, MD Date reviewed: September 2011
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Explore - My House
A 19th-Century Live/Work Factory in New York
Whether they're fabricating a dining chair, designing a line for West Elm, or building out a kitchen, Amy and Brandon Phillips find ways to reveal the unique histories and characteristics of the...
written by: Kirin J. Makkerphotos by: Ball & Albanese02.18.14 -
Lucy Marston's Timeless Farmhouse in Suffolk
When it came to designing a new home for herself and her family, one of the most important ambitions held by architect Lucy Marston was to create a sense of belonging.
written by: Dominic Bradburyphotos by: Damian Russell02.18.14 -
10 Dwell Houses, In Their Own Words
Dwell's "My House" section has been an integral part of the magazine since it was founded in 2000. Homeowners get the opportunity to describe how their modern home works for them, and supplies...
written by: Kelsey Keith11.13.13 -
Architect Couples At Home
When architects fall in love, designing their own home can be both rewarding and challenging feats. Through compromise and collaboration, these couples successfully made their dream home a reality.
written by: Kate Santos11.11.13 -
Japanese Inspired Summer Retreat
An architect recasts a 1960s artist's retreat in southeastern Norway.
written by: Diana Buddsphotos by: Ivan Brodey10.20.13 -
Designer Omer Arbel's Eclectic Home in Vancouver
Designer Omer Arbel develops his latest works inside an eclectic Vancouver home filled with a teeming assortment of pets and prototypes.
written by: Olivia Martinphotos by: José Mandojana08.02.13 -
Actor Bryan Cranston's Green Beach House Renovation
The star of Breaking Bad opens the doors to his family's recently completed beach house located just outside of Los Angeles.
written by: Amanda Dameronphotos by: Art Streiber06.13.13 -
Modern Furniture Fit for a Classic Eichler
Seeking a modern shell for their mid-century pieces, a pair of collectors found a relatively untouched Eichler in San Rafael, California—and a built-in excuse to acquire more furniture.
written by: Erika Heetphotos by: Drew Kelly05.17.13 -
Mid-Century Modern in the House
Take a closer look at the trove of mid-century modern pieces that fills the breezy San Rafael, California, Eichler from our June 2013 Furniture issue's My House—where Hans Wegner, Knoll, and Herman...
photos by: Drew Kelly05.08.13 -
Converting a Commercial Storefront to a Home (and Studio!)
Seeking more space and a connection with the city, an artist and a designer turn an old Toronto storefront in Dundas West into a home and studio.
written by: Alex Bozikovicphotos by: Naomi Finlay03.27.13 -
A Hybrid Prefab Home in Upstate New York
For a vintage design dealer seeking a respite from the city, architect William Massie conceptualized a mostly prefab home around a carefully curated furniture collection in upstate New York.
written by: Erika Heetphotos by: Karina Tengberg02.27.13 -
Handled With Care
In Warsaw, Poland, a resident breathes new life into an old apartment by dismantling, then reassembling, his late grandmother's hodgepodge of wooden furniture and creates a self-contained do-it-all...
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A Budget Friendly Brownstone Renovation in Brooklyn
A family enlists Brooklyn design-build firm MADE to renovate a brownstone using surplus and salvaged materials for a budget-conscious patina.
written by: William Lambphotos by: Matthew Williams01.18.13 -
A Lakeside Prefab in New Jersey
A New Zealand expat and her son use their prefabricated lakeside New Jersey retreat as an outdoorsy counterpoint to city life.
written by: Kelsey Keithphotos by: Mark Mahaney12.20.12 -
Warsaw Loft with Multifunctional Furniture
To maximize their small Warsaw loft, transatlantic designers Aleksander Novak-Zemplinski and Becky Nix handcrafted a fleet of double-duty furnishings.
written by: Sally McGranephotos by: Andreas Meichsner11.20.12 -
An Airy Addition to a Historic Boise Home
An airy addition on the back of a historic house in Boise is a model of sensitive renovation, seamlessly melding new and old.
written by: Jaime Gillinphotos by: Lincoln Barbour10.01.12 -
Party-Friendly Apartment in Toronto
Dr. Kenneth Montague's Toronto loft is both home and art gallery—and the ultimate party house, thanks to two kitchens, a rooftop deck, and no shortage of conversation pieces.
written by: Alex Bozikovicphotos by: Naomi Finlay08.09.12 -
131-Day House
Architect Jayna Cooper had never designed a house before, much less played general contractor, when she broke ground on her new home in the middle of Los Angeles in 2009. After a grueling four...
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Designer Jaime Hayon's Renovated Home in Spain
The internationally acclaimed designer Jaime Hayon takes us on a personal tour of his newly renovated home in Valencia, Spain, offering decorating tips along the way.
written by: Zahid Sardarphotos by: Nienke Klunder05.23.12 -
Grateful Shed
A family discovers the joys of DIY design—and muddy feet—in their home made up of distinct pods that blends harmoniously with its surroundings in the rainy mountains of Kauai.
written by: Erika Heetphotos by: Linny Morris03.12.12


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NAVIGON North America is a fully-featured navigation app for iPhone and iPad and the good folks at Garmin have supplied with with 10 promo codes to giveaway to you, our awesome readers! For a chance to win, all you need to do is leave a comment below!
Some of the feature highlights of NAVIGON North America include premium road guidance that goes beyond just turn-by-turn directions like visual lane guidance, speed limit warning, parking information, and realtime traffic, onboard maps with map manager that allows users to download maps of individual states to save on storage, sophisticated app views including panorama view in 3D, public transit routing with Urban Guidance, Goggle Street View and more.
If you want a chance at getting your hands on this excellent navigational tool for your iPhone and iPad, just leave a comment below for a chance to win!
I would love to win this. I've seen one of my co workers using it and thought I should get it too, but it's way too expensive for me.
Finally an opportunity to know where the heck I'm going. Now if only they had navigation maps for the iOS creators so they would know where they are going.
I have loved Tomtom all this years, if Navigon is ready to give away a free to try, I would jump on it in a heartbeat!
I love Navigon, I have suggested this app to many people and they love it as well. I have the EastCoast version and travel often enough to Chicago where I considered purchasing the full USA version, this win would be very helpful.
I've heard so many wonderful things about this application. i really hope that I can win this and try it out in greater detail. unfortunately the price of the application is keeping me from buying it out right. Maybe this will change that?
First time commenter, but love following the blog! I love my wife more than anything. An incredible woman for already having one home birth and attempting her second after just 17 months. But she is awful at directions. She really needs this :)
As someone who drives a thousand miles per week, I respectfully submit my name for the app because I FREAKING WANT IT!!!!!
Thank you for your consideration.
Whew! Took me a while to navigate to the end of this section! (Sorry, was all I could come up with this time of night...)
Pick me, I am the one. Loved the navigon GPS units. Would love to replace it and Apple Maps with this App
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For more details Order provide us with your (full name, delivery address and phone number)
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IMORE is awesome! I can't believe they are giving away a $60 app, I would love to be one of the lucky ones to win.
My iPhone maps app wont even recognize my home address as it is in my Contacts. It takes me to the wrong city because my street runs through two towns. Navigon is necessary so I can get home. LOL
Travel all the time and I would love to try this Navigation app. Plus, I follow you on Twitter Miss Lofte!
This looks like an awesome app, and would be a great to have. I just wish I were in a better financial place to afford it for my driving trip to the west coast to see the outlaws (actually the in-laws) this December!
I would love to win this as my wife just broke my Garmin GPS...time to move into the new century with Navigon.
Navigon is the best map app on ios. I tell everyone about it. Now it's a matter of winning this from you!!
Help me find my way...iLost. I would love to help make one of your Navigon codes be gone...just give it to me.
Navigon has always looked like one of those apps that could replace my Garmin Nuvi. Would love to be a winner and find out. Beautiful looking product.
I am a new follower of iMore and I have to say, its great! I'd really appreciate the opportunity to use this software on a daily basis.....for FREE!
PS - Keep up the good work on the Podcast. I follow you every week now and love it!
I do communion calls for my local Church and have to drive to new areas all the time. My sense of direction is so bad, that it's sometimes to the point of panic. This would really help me get to the folks i need to see.
Was thinking of purchasing if they have another Black Friday sale this year..but free is always better!
Working on the road, it is easy to get lost. Having a reliable GPS navigation system makes life less stressful.
Pretty cool looking, but I'll stick with Apple Maps. Despite all the hype, Apple Maps has worked perfectly for me since it was released!
I had a Navigon stand alone unit for quite awhile. I loved the interface, and I'd love to give the app a try.


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adidas Celtics Personalized Revolution 30 Swingman Alternate Road Jersey
Price: $119.95
- Additional Details
- Brand: adidas
- Color: Green/Black
- Fit: Standard Fit
- Made Of: 100% polyester
- 100% polyester
- Sleeveless jersey
- Resembles on-court NBA jersey in cut and aesthetics
- Screenprinted twill custom name and number on back
- Screenprinted twill team name and custom number on front
- Back neck taping
- Updated NBA Swingman® jock tag
- NBA Logoman® on left chest
- adidas® wordmark on right chest
- Officially licensed NBA product
- Made in Honduras
Unconditional satisfaction guaranteed.
Safe Shopping:Confidentiality and privacy secured.
FAQ:Quick answers, easy solutions.


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Tribune-Star/Jim Avelis Trouble: West Vigo quarterback Jimmy Maples is brought down by Greencastle defender Dustin Williams.
- Latest News
- Possible bookkeeping 'abnormalities' under scrutiny at TH airport Posted 12 hours ago
- Vigo County Jail Log: March 10, 2014 Posted 19 hours ago
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- UPDATE: Indictment alleges deputy committed violence against suspects Posted 15 hours ago 1 Photo
- Sandy Hook shooter's dad: 'You can't get any more evil' Posted 16 hours ago
- Feds arrest Putnam County deputy on charges of violence Posted 19 hours ago
- Police: Meth organization dismantled in Vigo County Posted 20 hours ago 5 Photos
- 10 Things to Know for Monday Posted 21 hours ago 1 Photo
- 4 couples sue Indiana over same-sex marriage ban Posted 3 days ago
- Vigo County Jail Log: March 7, 2014 Posted 3 days ago
- US employers add 175K jobs despite harsh weather Posted 3 days ago
- Bill for welfare drug testing in negotiation Posted 3 days ago
- Book signing March 7 in Crossroads Café to benefit Success By 6 Posted 3 days ago
- Groups ask regulators to probe plant's power woes Posted 3 days ago
- Nature trust expands Owen-Putnam State Forest Posted 3 days ago
- TribStar.com Poll
- AP Video
- Wallabies Run Amok in Aussie Town Methodists End Minister's Same-sex Wedding Case Aviation Experts Say Missing Jet Will Be Found Holder: Heroin an 'urgent Public Health Crisis' Snowden: 'Yes Absolutely' Would Leak Again Pistorius Vomits While Hearing Court Testimony Minnesota GOP Lawmaker Apologizes for NBA Tweet As Tensions Grow in Crimea, Russia Warns Ukraine Security Enhanced for 2014 Boston Marathon Investigators Chase 'every Angle' in Missing Jet Investigators 'Puzzled' Over Missing Jet's Fate Palin Reads Dr. Seuss at CPAC 6.9 Earthquake Shakes Far-Northern California Nome Prepares Iditarod Sled Dog Race Finish President Congratulates NCAA Champs Skydiver, Pilot Survive Midair Accident Lambert, Underwood Team Up for New Duet 3D Printed and Driverless Cars on Show in Geneva Radiation ID Cards to Monitor Child's Exposure Questions Surround Malaysia Jet Disappearance
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- Miley Cyrus Has a Wardrobe Malfunction Snowden: 'Yes Absolutely' Would Leak Again Raw: Hungry Bear Goes Out on a Wire (Full Video) Walk at Work Funny PSAs Warn Colorado Residents: Drive High, Get a DUI RAW VIDEO: Climber rescued from the side of Shortoff Mountain Justin Bieber And Selena Gomez Go On Multiple Dates CI Exclusive: Mike Krzyzewski On Leadership Dozens Of Students On The Mend Following Freak Stage Collapse 'eSports' making stars out of computer gamers Boy With Only Six Months To Live Celebrates Birthday Skydiver, Pilot Treated After Midair Accident Mom Arrested For Attacking Child's Classmate TV Show Features Women Who Escaped North Korea Man Killed Trying To Rescue Pets From Overnight Fire Raw: Mom Accused of Driving Into Surf in Court Best Moments from 17 Seasons of 'The Bachelor' Finales Nike launches new 'Magista' soccer cleat Dunk of the Year? How to Make a Strong Password (and Actually Remember It)
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Click HERE to read all your Parade favorites including Hollywood Wire, Celebrity interviews and photo galleries, Food recipes and cooking tips, Games and lots more.
Click HERE to read all your Parade favorites including Hollywood Wire, Celebrity interviews and photo galleries, Food recipes and cooking tips, Games and lots more.


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- Welcome to Season 2013/2014
- Season Calendar
- New Productions 2013/2014
- Revivals 2013/2014
- Recitals 2013/2014
- Concerts 2013/2014
NOW! Opera for You/
events for children
and young people - Special Events 2013/2014
- Subscriptions
- Tickets, Extra Services, and more Information
- DVD of our Ring des Nibelungen
- Series of Live Recordings made at Oper Frankfurt
- How to Find Us
- News
- Videos
- Cast Changes
- Partners
- Patronage
Bálint Szabó
Bálint Szabó was a member of the Hungarian, Roumanian and Hamburg state operas before joining the Ensemble at Oper Frankfurt (2005/06-2008/09), where roles included Don Giovanni, Mephisto (Faust), Colline (La Bohème), Fiesco (Simon Boccanegra), Banco (Macbeth), Zaccaria (Nabucco), Don Profondo (Il viaggio a Reims), Raimondo (Lucia di Lammermoor) and, as a guest, Lodovico in Otello. He returned to Frankfurt again in the 2012/13 season for Tom in Ein Maskenball/Un ballo in maschera, Sid in La Fanciulla del West and Sire de Béthune in The Sicilian Vespers (both new productions). Bálint Szabó recently sang Sarastro (Die Zauberflöte) at the Opéra Nice and the Opéra national du Rhin in Strassbourg. Other engagements in recent seasons have included appearances at the Deutsche Oper am Rhein, the Bayerische Staatsoper in Munich, the Staatstheater in Stuttgart, the Grand Théâtre in Geneva, Athens National Opera, the Royal Opera House Covent Garden London, Teatro alla Scala in Milan, Teatre del Liceu in Barcelona, Théâtre du Capitole in Toulouse, Teatro Municipal Santiago de Chile and the New Israeli Opera in Tel Aviv.


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Clemson Tigers Gear
Clemson Tigers Home Office & School
Clemson Tigers Home Office & School Wall Art
less than $10
(2 items)
Product ID: 521384
Main Content
Add a bit of Clemson school spirit to your fan territory when you decorate with this 8" x 10" framed Campus photograph. This high-quality photograph of your school's most prominent landmark is overlaid by team graphics and team color hues at the side and bottom. It's also fitted with a simple black glossy frame, so your bold team pride is sure to shine through for all your visitors to see!
- Measures 8" x 10"
- High-quality photographic print
- Team logo and colors
- Glossy black frame
- Ready to hang
- Imported
- Officially licensed collegiate product
Tigers Fanatics also liked:
Special event items are produced by manufacturers only after the outcome of a game
or event. These are advanced sale items and will ship immediately after they are
received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items
are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite
number, and/or designs. Some options may be limited by league rules.


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Main Content
The winter months can be tough on San Francisco fans, but watching your 49ers dominate their competition makes enduring the weather worthwhile. Don't let the cold distract you; wear this Stripe Out knit hat from New Era to warm up and keep your head in the game. This beanie features woven team-colored stripes, an embroidered team logo on the cuff, and a soft pom to top it all off. With this knit hat's warmth and spirit, you won't let the cold stop you from cheering your 49ers to victory.
- 100% Acrylic
- One size fits most
- Double layer knit beanie
- Woven graphics
- Quality embroidery
- Imported
- Officially licensed NFL product
49ers Customers also liked:
Special event items are produced by manufacturers only after the outcome of a game
or event. These are advanced sale items and will ship immediately after they are
received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items
are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite
number, and/or designs. Some options may be limited by league rules.


text: New Macbook Pro Line Rumored Nerds, start your salivating. posted on February 24, 2011 at 6:47pm EST Time.com BuzzFeed Partner posted about 3 years ago I know, right? Now tell your friends! New Macbook Pro Line Rumored Time.com Share Tweet Stumble Email . LINK New Macbook Pro Line Rumored techland.time.com Check out more articles on BuzzFeed.com! Share On Facebook Tweet Pin it Share Tweet Pin it Email More ▾ Tweet Share Pin it Rebuzz Reddit Stumble Link Share Next On BuzzFeed Video › This Look At What The World Eats For Breakfast Is Unbelievably... Next On BuzzFeed Video › Things Rappers Do That Would Be Creepy If You Did Them... Special Reactions Your Reaction? 0 OMG Old WTF LOL Cute WIN Yaaass Fail Trashy Ew LOL Amazing Blimey Splendid WTF Hmm Trashy 0 You are signed in as . Saving... Saving... Saving... Rebuzzed! This post has been added to your Feed I know, right? And there's more where that came from. Totally! And there's plenty more to love! Broken hearted? Maybe you'll like something over here instead? Oops! It looks like you've already voted.. Sorry, you can only react up to three times. Please Validate Your Email Thanks for Registering! Before you can vote or contribute we need to quickly validate your email address. We've sent you a confirmation email with instructions. If you don't receive the email in a few minutes, please check your spam folder. Reconnect? It looks like you've been disconnected from Facebook. Click the Facebook Connect button to reconnect. Don't Connect I know, right? Will your friends agree? Share this Link New Macbook Pro Line Rumored http://www.buzzfeed.com/time/new-macbook-pro-li... Nerds, start your salivating. Your link was successfully shared! HOT ON Follow BuzzFeed 29 Hairstyling Hacks Every Girl Should Know 199,577 repins 31 Impossibly Fun Wedding Ideas 141,920 repins 42 People You Won't Believe Actually... 110,291 repins 36 Life Hacks Every College Student Should... 108,359 repins 24 Times The Cast Of "The Hunger... 107,383 repins 31 Grilled Cheeses That Are Better Than A... 105,235 repins 74 Of The Tiniest, Most Tasteful Tattoos Ever 103,831 repins 12 Things You Probably Didn't Know About The... 98,239 repins 19 Pregnancy Lifesavers That Will Help You... 94,739 repins 19 People Who Are Having A Way Worse Day... 87,460 repins QUIZ: Which Disney Prince Is Your True Love? 80,856 repins 27 Life Hacks Every Girl Should Know About 73,401 repins 33 Insanely Clever Things Your Small... 73,358 repins 19 Adult Jokes In Cartoons That You Never... 72,912 repins Disney Men Without Beards Is Hilarious 70,623 repins 32 Pictures You Need To See Before You Die 69,668 repins 12 Questions Disney Forgot To Answer About... 69,218 repins 25 Fascinating Facts You Might Not Know... 62,417 repins 27 Pictures That Will Change The Way You Eat... 61,436 repins 74 Matching Tattoo Ideas To Share With... 59,971 repins Load More Pins 27 Shocking And Unexpected Facts You Learn In… 18 Microwave Snacks You Can Cook In A Mug The 13 Creepiest Things A Child Has Ever Said To… 26 Problems Only Anxious People Will Understand Facebook Conversations Preview Your Response Add Your Response Text Image Video Link Title Thumbnail (Allowed HTML Tags:     ) Title Video Embed or URL () Hey! This video may have privacy restrictions. Ensure that it is publicly visible to everyone. Description (Allowed HTML Tags:     ) Title Image Link Image To (optional) Description (Allowed HTML Tags:     ) Title Thumbnail Title Link URL Share this on Facebook (Connected as [Disconnect]) Cancel ∨ Create Full Post ∧ Create Simple Post You are signed in as Please Validate Your Email Nice Work! Thanks For Contributing! × Don't forget to share! Want to add another one? Go for it! Contributions Load More Responses... PRESENTED BY Promoted by FEATURED PARTNER Connect with BuzzFeed Facebook Twitter Youtube Tumblr Pinterest BuzzFeed Apps RSS Feed Hot Buzz If You Could Attend Any Concert In History, Who Would You See? Justin Bieber's Deposition Video Is The Most Uncomfortable Thing Ever This Russian TV Presenter Is Obsessed With The Color Of Obama's Hair Get more world Buzz › Now Buzzing 19 Things You Should Never Say To A Bride-To-Be Weird And Crazy Laws From Around The World 22 Lies You've Told As A Restaurant Server 4 Body Questions You're Embarrassed To Ask This App Will Help You Avoid Everyone In Your Life Which TV/Movie High School Would You Attend? 18 Fashion Bloggers You Need On Your Radar 50 Insanely Cute Prom Dresses Under $50 25 Things People Do In The Bathroom That Are Better Than Going To The Bathroom You've Been Playing "Duck, Duck, Goose" Wrong Your Whole Life 19 Impeccable Style Tips From "Dynasty's" Alexis Carrington


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Call Us Today! 1-800-351-8234Home | Account | Cart | Checkout
We believe our products should work for our customers. We test the products ourselves and stock only products that are high quality and offer good value. We describe our sharpening products truthfully and only suggest products that we feel will work for you.
If you are not satisfied with any of the products you purchase, we will provide you with a full refund or exchange within 90 days of purchase. There is no restocking fee. Contact us at firstname.lastname@example.com if you have any questions.
John CarmonaOwnerSharpeningSupplies.com
SharpeningSupplies.com Copyright © 2006-2014 Wingra Direct Phone Orders: 1-800-351-8234


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11,000 La Quinta Returns points for a free night stay. Not a member? Join Now
Escape to Date NightIt is time for the two of you to unwind and re-connect.
Premium Outlet ShoppingHave a fun filled day of shopping!
A Passion for RomanceEnjoy the ambiance of a romantic King Suite & a passion filled basket of goodies.


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Home Featured ProjectWelcome!Hi! My name is Jim Barry, and that's me in the picture at the top of the page, where I am making some gingerbread for the porch on our home. My wife and I own/operate WoodworkersWorkshop® and we are here every day during the week servicing our customers. I am a woodworker too so if you are interested in the type of projects I build, I do a little bit of everything and always willing to try something new. You can see my work portfolio at my personal web site, WoodchuckCanuck.com The online store is open 24 hrs of course, but if you need to reach us directly, we are here 7AM-4PM Eastern Standard Time (Mon-Fri). Most of the time the person who picks up the phone will be me, since I handle all store orders. We also monitor customer service emails over the weekend too. What is a woodworking plan?So you like what you see in our store but are confused as to what a woodworking plan is? A woodworking plan is a detailed set of instructions to build the project shown. Instructions include sufficiently detailed explanations accompanied with drawings and diagrams. Many of our woodworking plans have full scale drawings which make it a lot easier for a beginner woodworker to build their project. Painting instructions are provided in the project instructions. For an example, click on the Halloween project pictured above and visit the product page. Then click on the View Larger Image Slideshow.Who is WoodworkersWorkshop®?Since 1998 WoodworkersWorkshop® International Distribution Center (IDC) has been the online purchasing and distribution center for many of the highest quality woodworking plans and carpentry products available to date. We currently have over 9,000 items in our online store. Watch our inventory grow! Our objective is to provide woodworkers with a one-stop location where they can view details of projects they want to build, from the various companies that offer a full range of woodworking plans.Why are we in business?Our Mission Statement is two-fold:
We currently provide customer order management for 25 American, Canadian and New Zealand plan designers, pattern makers and book publishers. We recognize that there are many companies that sell woodworking plans and patterns. But unlike most, we also provide printing and mail order distribution for a number of these designers. We have full color tabloid sheet, stapled booklet services for professional printing. And we also offer our wide format printing and scanning services to help designers develop their patterns full size, using our 36" wide plot printer (example). If you or your company designs, distributes and/or sells woodworking plans, wood products or kits... we want to hear from you! Contact Jim Barry via email or telephone. We believe, along with our woodworking designers and publishing partners, that customer service is the key to success. That's what we are here for, to service you the customer. We appreciate all feedback. What do we sell?What we sell here are mostly woodworking plans to build the items we display in our product listings. We sell paper plans that are mailed to you. We also sell a selection of downloadable plans. You can see which plans are downloads because they have PDF in the name of the project. Click here to read our FAQ on how to download a PDF plan in 4 easy steps and try out our free PDF plan offer!We also sell a variety of hardware supplies and wood products that drop ship direct from warehouses in the USA to provide the most cost effective shipping. The majority of our plans come with full-sized templates to make it easier for you to build your project. The individual product descriptions will outline the specifics of each woodworking plan. Please understand that we do not sell the actual pre-built item and neither do we have a source as to where you can find someone to build a project for you. We suggest you speak with neighbors, local schools or community colleges and even your local lumber store project desk. Any of these sources may know of woodworkers in your area. When you see a listing for a dining room table for 14.95 or a Christmas Yard Art Nativity Scene for 11.95, you are choosing to buy the woodworking plans to build the item, you are not buying the actual item pictured. Where do we ship from?We ship to customers all over the world. The paper woodworking plans are mailed to you either from our Canadian warehouse or direct from the designer themselves located throughout the United States. You can chose or we will decide which method works best for servicing you, depending on your location and our on-hand inventory. Speed of delivery and cost-effectiveness to the customer is the goal. We also sell electronic PDF plans (downloads).When do we ship?We ship every day using the USPS and Canada Post Office systems. We offer first class mail service, as well as Registered Mail service. Some of our book publishers offer UPS.Online Store Featured Items
Search the Store
Your Shopping Cart
There are no items in your shopping cart. Downloadable Plans
Only the product names with PDF in the title are downloadable. Download right away on the checkout page after your purchase! Customer Order Status
We understand that our customers would like to receive their order as quick as possible. We do our very best to process your order right away and ship within 24-48 hrs. We email all of our customers an Order Status web page link. We encourage all of our customers to visit that page so that they can get the most recent information about the status of their order and what, if any, external factors might affect the delivery of their order. Back orders do occur from time to time. Shipping Charges & Options
With the complexity of our inventory it can be difficult to determine actual shipping cost to display on your checkout page. If the delivery charges seems high you are invited to inquire first before you order. We do refund shipping costs if its determined we can ship for less. We will mail your paper plans and hardware supplies order based on the delivery option you choose on your checkout page, however if we can find another method to speed up potential delays at a particular warehouse we will make that change for you. We ship USPS first class mail and CanadaPost standard mail. Where available, we also offer Priority Mail offered by the post offices. The estimated delivery times are shown on the check out page based on the method of delivery, where it is shipping from and where the shipment is going. Please read our FAQ page for more information. Payment and Processing
Orders have to be paid for before they are processed. When you submit your payment information of your credit or debit card or PayPal, your account will be charged at the time you place your order. We accept Our store checkout page is https compliant (secure). |


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Starting from * $1,149 USD
One of the best things about Europe is that there are seemingly endless ports of call. From Naples, Italy to Bergen, Norway, Royal Caribbean International®; makes it easy for you to explore more historic European cities and countries in one fantastic vacation. The hardest part is choosing where to start.
*During inclement weather and select hours, the ship may permit the Solarium Pool to be used by persons under age 16 provided they are directly supervised by a parent or guardian.
**Concierge Club reserved for Diamond Plus and Pinnacle Crown & Anchor Society members, and select suite guests. Diamond Lounge available for Diamond and above tier level members.


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Soft Structured Carriers
Baby Bjorn Active Carrier
" Awful straps around the back, very uncomfortable. Dangling crotch area is obviously uncomfortable for baby as well. I hate it! " --Ps Mamae
BABYBJÖRN Baby Carrier Original
" This is the carrier I used for small infants. It is the easiest to get them into and out of. I own two of the same ones, one for in the house and one for the car. Also good for babies who like to face outwards. Once the babies get bigger, though, the straps dig into your shoulders. It is great for easy, short trips like the grocery. " --nicolerenee515
Ergo Baby Carrier
" My husband and I are anti-"baby bucket." Everyone these days seems to carry their baby around in a plastic bucket with a handle, holding her at shin height and putting her on the floor for convenience. When I got pregnant, we swore we would never be "bucket people." We didn't know it at the time, but we were destined to become Ergo people instead. Need to get your..." --JulieInChicago
ERGO Baby Organic Carrier
"I used the Ergo with my first until he was nearly three. He preferred to be on my front most of the time, right up till the end. We used it for grocery stores, walks, travel (so great for airports!) and some epic hikes. I am now using it for my second baby, age 3 months. She was too big for the newborn insert (birth weight 11 lbs, 4 oz and the insert goes to 12 lbs!), so I had..." --MinneapolisMama
ERGO Sport Carrier
" We use this carrier all the time. We love to hike and walk all over town with this carrier. One thing that I really like is that the ERGO sport carrier keeps me cool on the outings which is no small feat carrying a little love oven everywhere. Definately worth the price if you want a carrier that can take long hikes. Sometimes it seems like the straps slip on long hikes and..." --psmama


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Main Content
Make sure you never get called for a fashion foul ever again when you sport this Double Dribble premium tee from Mitchell & Ness to your next Bulls game! This stylish tee features a distressed throwback team logo, team name and "'93 NBA Champions" lettering across the front, along with team-striped collar and cuffs for an unstoppable team look that will give you those extra style points you've been craving.
- 100% Cotton fabric
- Lightweight ribbed T-shirt
- Distressed screen print graphics
- Rib-knit collar & cuffs with striped detail
- Tagless collar
- Reinforced taped collar seam
- Sewn-on Mitchell & Ness tag
- Imported
- Officially licensed NBA product
Bulls Customers also liked:
Special event items are produced by manufacturers only after the outcome of a game
or event. These are advanced sale items and will ship immediately after they are
received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items
are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite
number, and/or designs. Some options may be limited by league rules.


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California is a modern range of creative furniture in oak veneer*. Mix and match the component parts to design a truly individual home study solution.
*Free delivery over £50 refers to home delivery orders placed on diy.com only. Charges refer to the value of goods being delivered and excludes delivery from stores or services. Excludes bulk delivery.
B&Q accepts the above cards and also offers a range of in-store financial services. Learn more
© B&Q 2014 - Terms & Conditions


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LPFM License Application Process - Frequently Asked Questions
November 15, 2013 (Updated)
The Federal Communications Commission (FCC) will accept electronically filed low power FM (LPFM)...
2013 Cable Industry Price Survey Download Site
April 10, 2013 (Reviewed)
The new Web-based electronic filing system is now available. Cable Industry Price Survey (...
Advisory for Analog Cable Television Subscribers
December 12, 2012 (Published)
This advisory applies to customers of cable television systems that carry both analog and digital...
Online Public Inspection File Access and Information
August 3, 2012 (Published)
Below are links to sites with information and guidance for online public inspection files.
Media Bureau Events and Workshops
August 2, 2012 (Published)
Below is a listing of the tutorials the Media Bureau has conducted on a variety of subjects.
Frequently Asked Questions by Topic
July 17, 2012 (Published)
Below is a list of topics that link to Frequently Asked Questions and responses.
Captioning of Internet Video Programming
June 13, 2012 (Published)
Background Closed captioning is the visual display of the audio portion of video programming....
Customer Service Standards
April 2, 2012 (Published)
Pursuant to the 1992 Cable Act, the Commission adopted federal standards aimed at improving the...
License Renewal Applications for Television Broadcast Stations
March 13, 2012 (Published)
Renewal of licenses for commercial and noncommercial TV broadcast stations, Class A TV broadcast...
Most Common Form 323 Filing Errors
September 29, 2011 (Published)
Below is information on the most common filing errors and how to avoid them. Please read the...