text:
UNFCCC Publishes Notification to Parties Regarding Copenhagen Accord [viewed]
18 January 2010: The UNFCCC Secretariat has published a notification to parties (YDB/ DBO/drl) regarding communication of information relating to the Copenhagen Accord.
18 January 2010: The UNFCCC Secretariat has published a notification to parties (YDB/ DBO/drl) regarding communication of information relating to the Copenhagen Accord.
January 2010: The World Bank has issued a discussion paper titled "Monitoring and Reporting on Financial Flows Related to Climate Change," and is seeking comments. The study was prepared by the World Bank in consultation with the UNFCCC and the Organisation for Economic Co-operation and Development (OECD).
30 December 2009: The UNFCCC Secretariat has published the report of the centralized in-depth review of the fourth national communication of Canada (NC4) (CCC/IDR.4/CAN).
This meeting, hosted by ICLEI-Local Governments for Sustainability with numerous UN partners, will provide a global forum on urban resiliency and adaptation immediately preceding the UN climate talks in Bonn. Partners will share knowledge on: urban risk assessment; socio-economic and institutional dimensions; strategy, policy integration and mainstreaming; urban adaptation planning and practice; costs and financing of urban adaptation; and technologies for adaptation.
6 January 2010: The Clean Development Mechanism (CDM) has registered its 2,000th project, a biogas extraction and utilization project in Thailand, expected to reduce carbon dioxide emissions by more than 56,000 tons annually.
6 January 2010: The UNFCCC Secretariat has modified the status of ratification regarding amendment to Annex B of the Kyoto Protocol to reflect the fact that Israel and Ukraine have deposited their instruments of acceptance of the amendment to Annex B of the Protocol.
December 2009: The West African Development Bank (BOAD) has published a report in French on its role in the future climate change regime. The report, titled "New Treaty on Climate: Copenhagen 2009, role and place of the BOAD," discusses the enhancement of the Bank's environmental policy and proposed Carbon Initiative.
16 December 2009: The UN Food and Agriculture Organization (FAO) has joined the Adaptation Learning Mechanism (ALM), a collaborative knowledge-sharing platform on climate change adaptation. The FAO will strengthen the agriculture component of the platform and link its existing agricultural technology database (TECA) to ALM.
19 December 2009: The UN Climate Change Conference in Copenhagen, Denmark, took place from 7-19 December 2009, and included the 15th session of the Conference of the Parties (COP 15) to the UNFCCC and the fifth session of the Conference of the Parties serving as the meeting of the Parties to the Kyoto Protocol (COP/MOP 5).
16 December 2009: During its 51st meeting, held from 30 November-4 December 2009, in Copenhagen, Denmark, the Executive Board (EB) of the Clean Development Mechanism (CDM) agreed to launch a call for experts in order to replace outgoing members of the Methodologies Panel, the Afforestation and Reforestation (A/R) Working Group, the Small Scale (SSC) Working Group and the Accreditation Panel.


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In light of recession, PGA refuses to wilt
PGA Tour commissioner Tim Finchem was on Capitol Hill on Wednesday, attempting to put a positive spin on the tour's growing sponsorship crisis.
"I do think that this is a particularly bad downturn [in the economy], and we are concerned," Finchem said afterward at the National Press Club. "But we've been 100 percent sponsored during three recessions since I've been commissioner, and the reason is the players. They deliver."
There's no doubt Finchem has delivered since he took the reins of the PGA Tour from Deane Beman in 1994. Between Finchem's business acuity and Tiger Woods' success, golf has enjoyed a golden age of popularity and financial growth in the past 15 years.
Prize money on tour jumped from just under $66 million in 1994 to a high of more than $279 million last season thanks to the on- and off-course efforts of Finchem and Woods. The tour also surpassed the $1 billion mark in charitable donations in 2005 and last season set a record in the category with more than $123 million in charitable revenue.
But for the first time since 1994, total purses on the PGA Tour dropped this season ($277 million) in a precursor to what is certain to be the most challenging sponsorship climate of Finchem's tenure. Even Woods has experienced the pangs of the recession: Buick ended its nine-year endorsement relationship with the star a year early before the season in an effort to cut costs.
"We as a collective whole on the PGA Tour have to do a better job of making sure that we appreciate all the fans and sponsors for what they do for us and allowing us to have an opportunity to compete and play for a living," Woods said. "I think over the years we may have taken that for granted. But certainly now is a time that reality has certainly checked in."
And reality is taking a bite out of the PGA Tour's budget.
The tour always has experienced some annual sponsorship turnover as the expected fluctuation of any business plan. AT&T; ended its affiliation with the tour's Atlanta stop (the AT&T; Classic) last season. But at least five events on the original 2009 schedule will either disappear or need new title sponsors for 2010. Another will drop off the slate after 2010.
Conservatively speaking, another six events feature marriages to corporations that are either tenuously positioned in the marketplace, hemorrhaging dollars or implementing major cutbacks in discretionary spending. Any or all of the six could follow the 2009 exodus of Mercedes-Benz, FBR, Wachovia (Wells Fargo), Crowne Plaza, Ginn Resorts and U.S. Bank in terminating relationships with the PGA Tour.
Part of the problem is strictly financial. The recession has pounded PGA Tour sponsorship staples from the financial services and automotive industries. And part of the problem is public perception. Northern Trust turned PGA Tour sponsorship into a hot-button topic three months ago at the tour stop in Los Angeles.
Days after Phil Mickelson's victory at Riviera at the Northern Trust Open, the public became outraged at reports that the company had thrown lavish hospitality parties featuring gift bags from Tiffany's and acts like Sheryl Crow and Chicago for its employees and clients. At issue was that such revelry followed Northern Trust's acceptance of $1.6 billion in federal TARP bailout funding and the corporation's decision to lay off 450 employees.
"This type of spending is outrageous and disgraceful," said Rep. Elijah Cummings, Maryland Democrat. "The government did not hand over $1.6 billion for Northern Trust to go off partying or give away taxpayer-subsidized trinkets from Tiffany's."
The incident stigmatized PGA Tour sponsorship to some degree. Chrysler had already taken its name off the Bob Hope Classic to avoid public backlash. And in the wake of the Northern Trust debacle, Wells Fargo, which had recently swallowed floundering Wachovia, decided to take its name off the tour's event in Charlotte, N.C., abandoning funds already contractually committed to the event through 2012.
U.S. Bank (another TARP recipient), FBR and most recently Crowne Plaza terminated relationships with events in Milwaukee, Phoenix and Fort Worth, Texas.
"We went through a couple of months ago some criticism about whether or not it's appropriate for a company to entertain clients as part of the dollars that they spend," Finchem said. "Some of the comments that were made, they were isolated on a very narrow part of the value equation. Whether you're going have a dinner and have some musical entertainment, I think it's a very subjective thing. Whether you or I might go to a dinner that has Sheryl Crow playing, you might think it's lavish; I probably wouldn't, but then that's my opinion. These are decisions that should be left to companies to effectively use their dollars."
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KNIGHT: Riding the rails to insolvency at high speed
Taxpayers must pay the freight for over-budget train projects
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Father of three 'Home Alone' kids 'abandoned by mother while she went on honeymoon' vows to fight for custody
Chris Brooke
and James Tozer
The father of three young children left home alone for two weeks while their mother 'went on honeymoon' vowed to fight for custody on Tuesday.
Parvez Sadiq, 43, said he was 'disgusted' with his estranged wife Simten's treatment of the youngsters.
On Tuesday, it was claimed that a cousin of Mrs Sadiq had been staying overnight with the children, aged 11, six and five, and going to work during the day.
But neighbours who alerted police said they had not seen an adult at the council house in Leeds while Mrs Sadiq, 33, was away.
Home Alone mother Simten Sadiq: Left her three children to go on her two-week honeymoon
Although still married to Mr Sadiq, the Turkish-born mature student is said to have recently informally 'married' a lawyer in an Islamic ceremony in Austria.
There is no evidence they underwent a bigamous ceremony in the UK.
Social services are looking after the two girls and a boy, but Mr Sadiq, who says he had no idea the children had been left on their own, said: 'I am going to ask to take care of the kids.'
It has been claimed Mrs Sadiq left the three youngsters home alone for two weeks to go on a belated 'honeymoon' with her unofficial 'millionaire husband'.
She was believed to be flying home from abroad on Tuesday night and is expected to be arrested by police on her return.
Her children were thought to have been left to fend for themselves in their council house in Leeds and lived on food stockpiled by their mother.
They were seen playing outside last week, but a neighbour became concerned about the absence of an adult at the house and contacted police.
Detectives went to the three-bedroom terraced house at 9pm on Saturday and found the children hiding under a bed. They were healthy and had apparently been well fed.
As police investigated the circumstances of the children's care, a tangled background of marital strife emerged.
The children's father Parvez Sadiq, 43, said his marriage had broken down in the past two years, but the couple were still legally married.
He said his wife, a devout Muslim and mature student, met her new boyfriend over the internet on an Islamic dating website.
The father: Parvez Sadiq pictured with two of her children
Mrs Sadiq contacted her husband in April to tell him she had 'remarried' in an Islamic ceremony in Austria.
In August, Mrs Sadiq was seen by neighbours with her new man, carrying a balloon with the words 'just married' on it.
Simten Sadiq: Her children are aged 11, six and five
Mr Sadiq, a private hire taxi driver, lives only half a mile away from his estranged wife and their two daughters and son.
But he said he knew nothing about her absence until a social worker knocked on his door to tell him the children had been picked up by police.
He launched a blistering attack on his wife, saying: 'I am shocked, angry and worried. How can she do this? They have lost their innocence, their childhood.'
The cabbie added: 'It's very concerning for the welfare of the children. If she did leave them they must have been in a very, very strange situation.
'If I had known, obviously, I would have looked after them and made sure they had enough food.'
The father said social workers told him that his children had been taken into care and he is now hoping they can be reunited.
He said: 'I'd love to hold them and kiss them and make sure they are all right but it's out of my hands. I really hope I can see them. I'm just so worried about them.'
It is not known whether Mrs Sadiq has been in Austria for the past fortnight, but West Yorkshire Police have spoken to her and she is thought to be returning home for questioning.
British-born Mr Sadiq said he met his wife after putting a lonely hearts advert in a Turkish publication. Simten moved from Turkey to live with Mr Sadiq and they married in 1992.
The couple went on to have four children. Their eldest boy, 14, lives with his father.
The marriage ran into trouble after Mrs Sadiq decided to 'better herself' and began a college course.
Mr Sadiq said his wife walked out for the first time in November 2006 after she fell for a lecturer.
Police probe: The house in Alexandra Grove, where three young siblings were left for two weeks
He said he did not know if she cheated on him, but he was left to care for all four children alone and was forced to work at weekends while a relative helped look after the youngsters.
Mrs Sadiq returned to her family but allegedly walked out again in January last year.
She enrolled on an education course at Leeds Metropolitan University and Mr Sadiq
said he agreed to her request to have custody of the three youngest children.
With the children in her care she was given the three-bedroom council house in Leeds.
In April, Mr Sadiq was told by his wife she had remarried and that her new husband 'was a better lover than he was'.
She said her new man was a 'millionaire barrister and farmer from Austria'.
Mr Sadiq said his eldest daughter had been responsible for caring for her younger siblings. He added that he believed she was flying back to the UK on Tuesday.
A West Yorkshire Police spokesman confirmed officers called at the address after receiving a call from a member of the public on Saturday.
'Officers attended at the address and found three children and no adult present. They are now being cared for. The children do not have any injuries and appear to be fit and well.
'Police are now working with social services to establish the full circumstances surrounding the concerns and if any offences have been committed.'
Neighbour Granville Eastwood, 64, said he saw the children playing happily outside the house late last week.
'They are a lovely family and were very well turned out and well groomed as always.'
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Mortgage shortage and looming Budget cuts drive slump in house prices
- Average UK home now costs £208,552
Pressure: House prices are coming under pressure with potential buyers nervous of looming Government spending cuts, economic uncertainty and struggling to raise the mortgage finance they need
The slump in mortgage lending and pressure on household finances has continued to push down house prices, figures show.
Property prices fell by 1.4 per cent during January, under pressure from Government spending cuts and banks' unwillingness to lend to would-be buyers.
The drop left the average cost of a home just 0.5 per cent higher than it was in January last year at £208,552, according to the Department for Communities and Local Government.
It was also the eighth consecutive month during which the annual rate of house price inflation has fallen - and the latest rise was considerably lower than the 3.8 per cent jump seen in December.
The three-month-on-three-month change, which is generally seen as a smoother indicator of market trends, also pointed to an acceleration in the rate at which prices are falling.
Property prices dropped by 0.4 per cent during the three months to the end of January, compared with a 0.2 per cent decline in the quarter to the end of October.
House prices are coming under pressure as potential buyers sit on their hands as the looming Government spending cuts and economic uncertainty put further strain on already stretched household budgets.
Those who do want to press ahead with a purchase are continuing to struggle to raise the mortgage finance they need.
Last week the Council of Mortgage Lenders revealed just 28,500 loans were advanced to people buying a property during January, the lowest level since February 2009 and 29 per cent down on December's figure.
Howard Archer, chief UK and European economist at IHS Global Insight, said: 'The housing market will be pressurised over the coming months by high and likely-to-rise unemployment, negative real income growth, the increasing fiscal squeeze, very low consumer confidence, and ongoing difficulties in getting a mortgage, particularly for first-time buyers.
Falling: This British Bankers' Association graphic shows the main banks' net lending
'We suspect that house prices will fall by around 5 per cent in 2011
and end up losing around 10 per cent from the peak levels seen in the
first half of 2010.'
Annual house price growth is now negative in seven regions of the UK, with Northern Ireland continuing to see the biggest year-on-year drop of 14.1 per cent, followed by Yorkshire and Humberside at 4.6 per cent, and Scotland and the West Midlands, which both recorded a 3.2 per cent decline.
Growth was strongest in the East and London, with prices 4 per cent and 3.7 per cent higher respectively than they were in January last year.
But the recent price falls seem to have done little to help struggling first-time buyers get on to the property ladder, with the average cost of a home bought by this group increasing by 1.5 per cent during the past year, while the price of properties purchased by owner-occupiers has edged up by just 0.1 per cent.
There has also been an 8.6 per cent jump in the cost of new homes during the 12 months to the end of January, although the figure may have been distorted by the low volume of new-build properties that came on to the market during the period.
The number of new properties built fell to its lowest peacetime level since 1923 during 2010.
The number of people struggling to keep up with their mortgage increased for the first time in two years during the final quarter of 2010, figures show.
Around 38,800 homeowners got into mortgage arrears during the three months, 6 per cent more than during the third quarter and the first increase since the final quarter of 2008, the Financial Services Authority (FSA) said.
But despite the rise in new cases, the total number of people who were in arrears of at least 1.5 per cent of their outstanding mortgage fell for the eighth consecutive quarter to 343,400, 7 per cent down on the same period of 2009.
Just under 6 per cent of these borrowers have reached an agreement with their lender under which they are making only partial repayments, or their repayments have been temporarily suspended altogether.
A further 13,764 homeowners also collectively had £40 million of arrears added to their outstanding mortgage during the fourth quarter as a way of helping them to get back on track.
Overall, lenders are currently receiving around 56 per cent of the repayments that are due from borrowers who are in arrears, well up on the 41 per cent they were receiving at the end of 2008.
Repossessions fell by 10 per cent during the three months to 8,246, giving a total of 37,819 people who lost their home during the whole of 2010, well down on 2009's figure of 52,963 and the lowest level since 2007.
Today's figures are in line with ones reported by the Council of Mortgage Lenders (CML), which showed that the number of homes that were repossessed fell to 7,900 during the fourth quarter. A further 169,600 people were in arrears of 2.5 per cent or more of their mortgage balance.
The CML said a total of 36,300 properties were repossessed during the whole of 2010, also the lowest level for three years.
The FSA's figures are higher than the CML's because they include second-charge mortgages and loans advanced by lenders who are not CML members.
Repossession levels have remained lower than expected during the economic downturn due to a combination of low interest rates, Government support schemes and increased forbearance by lenders.
The FSA's figures also showed little sign that the mortgage market was improving, with total advances falling by 10 per cent during the final three months of the year, compared with the previous quarter, to just £36.8 billion.
Net advances, which strip out redemptions and repayments, dropped to their lowest level since the first quarter of 2009 at £3.4 billion, while the value of all mortgages approved was 9 per cent lower at £34.6 billion.
There was a marked shift in the number of people opting for fixed rate deals during 2010, as homeowners braced themselves for higher interest rates.
The FSA said 46 per cent of all mortgages taken out during the fourth quarter were fixed rate ones, up from 36 per cent at the beginning of the year.
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Photo by Juan Carlo, Juan Carlo / Star staff
Salvador Hurtado gets a radiator from Eddie Garcia, owner of Nash Radiator in Oxnard. Garcia is concern about the city closing Colonia Road at Oxnard Blvd where his business stands. The city is planning to close off at least two streets in the area.
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At the name of Jesus
- Instrument:
B-Flat Trumpet
- Ensemble:
Mixed Choir
- Format:
Vocal Score
At the name of Jesus by Ralph Vaughan Williams (1872-1958). For SATB choir and brass quintet. Mixed Voices. Sacred, Choral Leaflet. Vocal score. 8 pages. Published by Oxford University Press (OU.9780193851016).
ISBN 9780193851016. Sacred, Choral Leaflet.
Anthem for SATB choir and congregation, accompanied by brass quintet, with optional timpani and organ.
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At the name of Jesus
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Instrument: Voice Sheet Music B-Flat Trumpet Sheet Music Choir Sheet Music Horn Sheet Music Trombone Sheet Music Tuba Sheet Music
Ensemble: 4-Part Music Mixed Choir Music SATB Music
Genre: 20th Century Sheet Music British Sheet Music Christian Sheet Music
Format: Octavo Vocal Score


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I used to be an addict and now am trying to drink alcohol responsibly. Is this a good idea? Idk?
I've had drug and alcohol problems from 12-16 and I'm at the age where I can drink alcohol legally (19) and I like that I can drink. I even drank a few times but I didn't have enough to get drunk because my parents control my alcohol. I'm kinda worried I might end up going back to my old patterns once I start controlling my own alcohol intake and I sometimes even get cravings to do it. Do you think it's possible that I could go back to being a full addict? Idk what to do because I'm conflicted between desire and the dangers. Mostly because of Cory Monteith's death from drugs; I don't wanna die like that.
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Digging the adobo grilled shrimp with cucumber yogurt — plenty of spice and flavor for something that's just 120 calories.
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White Paper: Change your security paradigm with hardware-enhanced security on Intel® architecture and better protect your business from threats.
Podcast: Stuart Tyler discusses historic privacy principles and how a company can create an effective approach that enhances business.
Intel CSO Malcolm Harkins discusses enterprise security, ensuring privacy protections, and keeping the proper mindset in the midst of radical change.
Аппаратные функции, встроенные в процессоры Intel® Core™ vPro™, позволяют повысить уровень безопасности компьютера без снижения эффективности работы пользователей.
Brief: Intel IT's security business intelligence platform uses a large-scale CLS and real-time correlation engine to deliver faster threat detection.
Intel's BYOD program was built to facilitate eDiscovery –legal requests for data– stored on personally owned devices such as smartphones and tablets.
White Paper: McAfee Drive Encryption offers data protection for corporate and intellectual property and improves user experience and productivity.
The enterprise mobile security real-world guide explains mobility risks and how Intel® Core™ vPro™ processors increase security and productivity.
White Paper: Describes Intel® embedded technologies and McAfee software providing productivity, security, and manageability for enterprise business.
McAfee Deep Defender* detects and blocks kernel-based threats using signature- and behavior-based detection for superior malware protection.


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Come on in! Join Pinterest today...it only takes like a second or so.
Holiday Holly Wall - 23 Easy to Make DIY Christmas Ideas
elf on a shelf, leave a note explaining Santa gave some extra magic so he could get a hug goodbye, but still fly home
Free Printable: From the Desk of Santa Claus stationary (and creative ideas to use it:)
Fun! A quick, easy project for the kids: playful, pom-pom covered trees.
Pottery Barn Inspired NOEL Tutorial. (my blog flashback from 2010!)... I actually broke it apart this month & used it on my mantel #repurpose
Fingerprint christmas light craft for kids. -Repinned by Totetude.com
Have a lazy elf? This is perfect for those mornings when your elf on the shelf forgets to move. Here are 10 FREE printable poems you can print ahead of time! #elfontheshelf #ideas
Beautiful holiday drink. Just chilled ginger ale, thawed white grape juice (from frozen), and raspberries. Non alcoholic
Rice Krispies Trees with Reeses mini pb cup as the trunk
How to add wire, Velcro and magnets to Elf on a Shelf so that he's more poseable. YES I need this!!
Perfect drawing time... In a box!!
cherries or berries with cream cheese and cresent rolls. so easy for christmas!
25 Elf on the Shelf Quick and Easy ideas that take UNDER 5 Mins
Easy idea for a holiday mantel. Start with three letters and add a wreath or topiary for the center O.
Easy and Inexpensive DIY Christmas Gift Idea + Free Printable - 1 bag Hershey's Kisses 1 whisk Piece of ribbon Clear cellophane Package tie-on (Free download)
Christmas party treats: Snowman Cookies
Miss Kindergarten: Winter Craft Ideas- name christmas tree
Cute for Christmas! You can glue pom poms on twigs, spray paint some pine needles white, and place in ceramic elf shoes from the dollar store. What a cute idea :)
Fun for the Kids on Christmas Eve - Grinch Punch with Sprite and Lime sherbet and Green Sprinkles/sugar rim. this would be fun the night we watch the movie /or read the book!


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WEBSTER, NEW YORK – NOVEMBER 2011: Remember the on-board food ordering systems aboard the starships in the (pick your favorite) Star Trek series? After a long day battling deadly aliens, navigating thorny philosophical predicaments, and contextualizing the human experience, Captain (pick your favorite) would select a meal on a TV screen mounted on the wall and, moments later, food would be either delivered via high-tech dumb waiter or fabricated on the spot from raw chemical constituents. Well, now thanks to the iPad(r) and the visionary team behind Stacked, you too can order your food on a screen (deadly aliens, etc. optional). With an iPad at every table and an addictive app that allows customers to visually build their ideal burgers, pizzas, salads, and desserts, Stacked offers a glimpse into the future. And because everything about the California-based chain needs to live up to our hopeful expectations about that future, A/V integrator No Static Pro Audio Inc. (Burbank, California) delivered hi-fi sound to all three existing locations using eight-channel Ashly Audio ne8250pe amplifiers with onboard DSP and out-of-the-box network-ready integration.
From the customer's perspective, the iPad ordering system is transparent and easy to navigate. For example, the hamburger builder allows the user to drag tomatoes, lettuce, mushrooms, etc. from one side of the screen to a virtual burger on the other side of the screen. When they're finished, they hit "send to kitchen" and a sophisticated triangulation system determines the table of origin and then communicates the order to the cooks. When they're finished, customers have the option of using the built-in credit card readers to pay for their meal with the iPad. "I think it's worth pointing out that the food is really, really good," asserted Eugene Gordon, CEO of No Static Pro Audio Inc. "The technology will get people in the door once, but the quality of every other aspect of their experience will keep them coming back."
Music is a high priority at Stacked. Chief information officer Brian Pearson is passionate about selecting upbeat tunes from across a range of contemporary genres. The songs reside on a gigantic MegaSeg repository from which a week of back-to-back songs will never repeat – and never let the carefully molded Stacked brand topple. No Static Pro Audio Inc. came to the project on a recommendation from another contractor already involved in the creation of the restaurants, and the pairing couldn't have worked out better. "It's fun working with Brian," Gordon said. "He's knowledgeable and excited about new technology and great sound." To tie the Stacked music experience into the Stacked iPad experience, Gordon worked out a little app that allows patrons to review the last five songs that played, right from the table's iPad.
The sound system Gordon designed for Stacked is both high-performance and cost-effective. Eight-ohm ElectroVoice ZX1-90 full-range loudspeakers provide audio throughout the establishment and JBL SRX718S 18-inch subwoofers kick up the kicks around the bar and dining area. An Ashly ne8250pe paired with an Ashly WR-5 wall-mount remote control comprise the rest of the audio system. The ne8250pe delivers eight channels at 250 watts per channel into 4 ohms (and since Gordon ran two 8-ohm loudspeakers per channel, that's what they deliver). Moreover, the ne8250 has onboard Protea(tm) DSP and network integration – all in a single unit that is only two rack-spaces high.
Gordon reduced the cost of the project by turning to the Ashly model ne8250pe for the sound system amplification, matrix mixing, control and digital processing. The on-board 8-in x 8-out Protea(tm) DSP processor and matrix mixer provides overall equalization for the system, loudspeaker alignment & delay, and matrix mixing to allow, for instance, satellite TV audio for the bar and, at the same time, background music everywhere else. It also provides auto-leveling and brick-wall limiting. The programmable Ashly WR-5 allows Stacked staff to change volume separately in each zone. In addition, it allows them to select the MegaSeg playlist or the satellite TV as the input source for each zone.
"The Ashly ne8250pe is a high-performance, cost-effective, space saving solution for a place like Stacked," said Gordon. "We were able to tuck the two rack-space unit into the server rack located in the equipment room, which was dominated by the back-end iPad infrastructure. The amp is reliable, great sounding, and powerful – indeed, Stacked has tons of clean headroom. Mostly to offer peace of mind, we employed the ne8250′s network capability so that we could monitor and change its status remotely."
Be on the lookout for more Stacked locations opening up nationwide. Their plan is to open four to five of the restaurants each year!
With a greater than thirty-seven year history, Ashly Audio Inc. is recognized as a world leader in the design and manufacturing of quality signal processing equipment and power amplification for use in the commercial sound contracting and professional audio markets.
Related Topics: AES Newslink, AV Control Systems, CEDIA Newslink, CES Newslink, Hospitality, InfoComm Newslink, NAMM Newslink, News, NSCA Newslink, Product Applications
HARMANâs Soundcraft to Host âMixing with Professionalsâ Sessions at Prolight & Sound 2014
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Extron PoleVault Digital Systems Now Shipping


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A collection of news and information related to Placido Polanco published by this site and its partners.
Top Placido Polanco Articles
Displaying items 56-66
Thome dives into a new workout routine
Story | Feb 20, 2012 | 4:24 PMYou know an athlete is serious about getting in shape when he's willing to change his routine around at age 41. In an effort to aid and help mend his ailing lower back, Jim Thome dedicated himself this winter to...... -
Another year, another fun Media Batting Challenge
Story | Feb 27, 2012 | 4:25 PMIt's undoubtedly the highlight of every spring training for me --- the Media Batting Challenge. Lehigh Valley IronPigs pitching coach Rod Nichols and Phillies hitting coach Greg Gross were such good sports, and it's all possible because they're willing... -
Polly's sports hernias a constant hindrance last year
Story | Feb 22, 2012 | 4:24 PMI'll keep this brief since I wrote a story last week about Placido Polanco. The Phillies third base man got into town on Tuesday and arrived in camp Wednesday morning. As he walked through the clubhouse saying his hellos and...... -
Valdez trade comes as a surprise
Story | Jan 25, 2012 | 9:24 PMI immediately thought three things when I heard the Phillies traded Wilson Valdez to the Reds for inexperienced left-handed reliever Jeremy Horst (he's pitched in just 12 big league games), who will be a non-roster invitee to spring training. 1....... -
PHILLIES FILES: 3 Phils up for Gold Gloves, including Polly who spoke about his position change
Story | Nov 1, 2011 | 4:24 PMNo more wondering when the Gold Glove winners will be announced. ESPN2 will televise the first-ever Rawlings Gold Glove Awards show at 10 tonight. The one-hour telecast, hosted by Karl Ravech, John Kruk and Barry Larkin, will feature the announcement........ -
Medical updates on Howard, Hamels, Polly, Contreras, Pence, Gload
Story | Oct 28, 2011 | 4:24 PM The Phillies have provided the following medical updates: · First baseman Ryan Howard (ruptured left Achilles) had his stitches removed on Oct. 25 and has progressed to partial weight bearing. He has begun a rehabilitation program in... -
Phillies injuries worse than publicized
Story | Oct 8, 2011 | 9:24 PMHere is list of injuries according to the team. Three players have hernias. Cole Hamels and Hunter Pence had injuries we didn't know about. And Ryan Howard's is not good. ---Ryan Howard's MRI revealed a rupture of his left Achilles...... -
Phillies announce 25-man roster; Herndon, Blanton react to the news
Story | Sep 30, 2011 | 4:24 PMThe Phillies set their 25-man roster for the NL Division Series against the St. Louis Cardinals. The Phillies will carry: Two catchers: Carlos Ruiz and Brian Schneider Six infielders:Ryan Howard, Michael Martinez, Placido Polanco, Jimmy Rollins, Chase... -
Postscript on Sunday night's disaster
Story | Oct 3, 2011 | 4:24 AMThings were backward Sunday night. The Phillies tagged Cardinals ace Chris Carpenter for four runs and chased him after just three innings. Few saw that coming. Carpenter had allowed only one run in 15 innings pitched against the Phillies this...... -
Lineups announced for NLDS Game 1
Story | Oct 1, 2011 | 4:24 PMLineups for NLDS Game 1 Phillies: SS Jimmy Rollins, 2B Chase Utley, RF Hunter Pence, 1B Ryan Howard, CF Shane Victorino, LF Raul Ibanez, 3B Placido Polanco, C Carlos Ruiz, P Roy Halladay. Cardinals: SS Furcal, RF Craig, 1B Pujols,...... -
Howard, Ibanez, Halladay get CBP rockin'
Story | Oct 1, 2011 | 9:24 PMThe place was practically comatose with the Phillies trailing the Cardinals by two runs in the sixth inning of Game 1 of the NLDS on Saturday. Then Ryan Howard brought Citizens Bank Park back to life. The cleanup hitter turned......


text: A museum dedicated to Ganesh (or Ganesha, พระคเณศ in Thai), the elephant-headed, four-armed, pot-bellied god of the Hindu religion. The many statues, sculptures, and paraphernalia (more than 1,000 pieces total) are the private collection of a Thai artist. There's not a lot of English-language signage, but enough for an introduction to the diety who is one of the most popular... More


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Sony PlayStation 3 Games
BEYOND Two Souls - Complete package - PlayStation 3 From the makers of the award-winning heavy rain comes a unique, psychological ...action thriller featuring Academy Award nominee, Ellen Page, as the lead role. With a brand game engine, a compelling, original story, and a top-notch Hollywood cast; BEYOND: Two Souls promises to be one of the most immersive experiences on the PlayStation 3. Live the remarkable life of Jodie Holmes, a young woman who possesses supernatural powers through a psychic link to an invisible entity. Experience the most striking moments of Jodie's life as your actions and decisions determine her fate. Face incredible challenges as you traverse the globe against a backdrop of emotionally-charged events never before seen in a video game. Dive into a gripping and unpredictable action thriller starring Academy Award-nominee Ellen Page in the lead role Take full control of Jodie as well as the mysterious entity in spectacular action sequences Experience the cutting-edge technology from Quantic Dream that creates one of the best-looking games ever seen on the PS3 if(isI18NConvReq()){ $("#desc a").hide(); } This product is:Available for Gift Wrap Read More
Bundle Includes: * Playstation 3 Slim 250GB Console * Uncharted 3: Game of the Year Edition * Dust 514 game + over $30 of Dust DLC... (Voucher) * DualShock 3 wireless controller * AC Power Cord * AV Cable * USB Cable * 1 Month Free of PS Plus * X-Men Destiny * Spider-Man: Web of Shadows * Transformers: Revenge of the Fallen * 6 in 1 Accessory Kit includes: Remote, HDMI Cable, Cleaning Cloth, Wired Controller, Silicone case for controller, USB charging cable Read More
The Uncharted 3 and PlayStation Plus Bundle includes Uncharted 3: Game of the Year Edition and a slim chassis PS3? with a 250GB ha...rd drive, perfect for storing hundreds of dollars of free games that come with your 1-Year membership to PlayStation� Plus. Over $85 is value! UNCHARTED 3: Drake?s Deception? Game of the Year Edition showcases Nathan Drake?s journey through new challenges and includes over $45 of Bonus Content! PlayStation�Plus PS3? Bundle Includes 1-Year Membership to PlayStation Plus featuring: 12 Hit games each month Access member exclusive Game Betas, Demos and Features Exclusive discounts of 10% - 75% on the PlayStation� Store 1 GB of cloud storage and automatic game saves and system updates 6 Additional games unlocked for your PS Vita? system The 250GB PlayStation�3 System, with a built in Blu-Ray? player, can hold over to 1800 Games, 140 Movies, 99,000 Songs, and 40,000 photos, or a mixture of all. Read More
The Nightmare Queen has broken an age-old contract with mankind. Now the evil of the Faerie Kingdom is crossing into the Land Abov...e. As a sorcerer's apprentice, it is up to you to master the Magick of the Faerun and drive back the darkness. Using the PlayStation Move motion controller, Sorcery puts a wand in your hand, letting you perform spells and explore the Kingdom of Midnight. No two sorcerers are alike; every twist of the wrist and flourish of the wand adds to your personal style. Live the adventure as you hurl fireballs and conjure whirlwinds with the PlayStation Move. Read More
The evil Sorcerer Morgrimm has invaded Prince Edmund's Castle and plots to take over the kingdom, raising an army of skeletons fro...m beyond. Now you must fight Morgrimm and his minions to restore order to the kingdom! Use the fluid PlayStation Move motion-controls to battle your foes using swords, arrows, throwing stars and more! Let the adventure begin! Read More
The Journey Collector?s Edition features all three best-selling games from acclaimed indie developer thatgamecompany, Journey, Flo...wer, and flOw, for one low price. The collection also includes a wealth of exclusive bonus content that fans are sure to love, making this the ultimate edition for collectors to cherish for years to come. Read More
The Fastest LittleBigPlanet Ever
Sackboy returns in a completely new adventure where your fast-paced kartin...g will save the Craftworld universe. Get behind the steering wheel and get ready to race through fun-filled tracks, discover unlockables in open-world environments and battle in karting arenas filled with pick-up items and LittleBigPlanet-esque weaponry. Read More
Ratchet and Clank are back! The beloved duo return with an original single-player epilogue to the acclaimed Ratchet & Clank Future...: Tools of Destruction and Ratchet & Clank Future: A Crack in Time. Ratchet & Clank: Into the Nexus is a story-driven platform adventure with humor and heart, featuring outrageously upgraded weapons, extreme planet hopping and brand new worlds begging to be explored. Into the Nexus marks a true return to form for the acclaimed series. After one of the most infamous manhunts in galactic history results in the capture of Vendra Prog, Ratchet and Clank offer to escort the dangerous criminal to the Vartax Detention Center. After a daring orbital jailbreak at the forgotten edge of the galaxy, Ratchet and Clank find themselves lost in an abandoned sector. There, in deepest space, they uncover an inter-dimensional event that threatens the universe?and forces Ratchet to decide what?s really important. Read More


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Dice singles, including individual 4-sided dice, 6-sided dice, 8-sided dice, 10-sided dice, 12-sided dice, 20-sided dice, and more. Everything from polyhedral dice standard spotted dice, to alphabet and astrology dice.
Black Spherical 6-Sided Dice
$2.50 -
Dice in Dice, 6 Sided, Transparent Clear and Red Double Dice
$0.85 -
Dice in Dice, 6 Sided, Transparent Purple Double Dice


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Pch Mahjong Games
Different style related with mahjongg, just where you want to match two flooring by linking them through a pathway. Have some fun actively playing this cool board game like the mahjong games in withyou have to obvious all of the cards from the board by linking 2 cards related with thesame image. 6 cool games mahjong to have some real fun!.
Help this knight on that valiant pursuit to games save Princess Mahjong from the grips related with evil!. Concentrate to experience this version related with mahjong connect alongside particular effects!. Enter the The summer months pch Games of 2005. Exercise your brain with Winnie the Pooh's Brain Games!. Portray a Christmas themed game related with Mahjong since you select 2 similar signs.
All war games pch mahjong games games that you looking for will be here.
All pch mahjong games games that you looking for will be here.


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Advanced Instagram viewer and content discovery dashboard.
Get your daily updates from leading publications and social networks according to your interests and favorite topics.
April 06, 2012
Wildon Home Louis Philippe II Storage Panel Bed: Furniture : Walmart.com
awesome storage bed!
Category: Home Decor
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Palettes & Paints: Modern Masters Metallic Wall Paint
Indoor Garden Ideas
High/Low: Marble-Topped Coffee Tables
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Dip-Dyed Walls: Ombre Tiles from Clé
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3 Children Killed in Bronx Fire
Three small children were killed and at least three other people were injured in a fire at a Bronx apartment building on Friday night, the Fire Department said.
October 26, 2013, SaturdayPoised for 'I Do' as Soon as New Jersey Allows
Same-sex couples are scrambling to plan their weddings so they can marry as soon as the ruling allowing gay marriage takes effect on Monday.
October 20, 2013, SundayCar Chase, White House to Capitol, Has Fatal End
A woman with a young child was shot to death after turning her vehicle into a weapon, ramming her way through barriers at the White House and on Capitol Hill.
October 4, 2013, FridayNew York Today: A Day at the Races
What you need to know for Wednesday: a new public advocate, an autumn heat wave and the curious case of the mass public-drunkenness prosecution.
October 02, 2013, WednesdayVice Admiral Is Suspended in Gambling Investigation
Vice Adm. Timothy M. Giardina was the No. 2 officer at the United States Strategic Command before being suspended earlier this month.
September 29, 2013, SundayCourt Says Storm Evacuees Must Move
Victims of Hurricane Sandy who have been living in hotels since the storm lost a court battle against eviction and will have to find beds elsewhere, according to a judge's ruling.
September 28, 2013, SaturdayShots Ring Out in Footage Recorded During Kenya Mall Attack
Video recorded during the militant attack in a Kenyan mall showed terrified customers taking cover as shots rang out.
September 22, 2013, SundaySecurity Officer Is Charged With Setting 8 Fires at 2 Manhattan Hotels
Over four years, Mariano Barbosa Jr. started the blazes at the Yotel and the SoHo Grand in an attempt to make the hotels less popular and his job easier, fire officials said.
September 22, 2013, Sunday3 Queens E.M.T.'s Are Held in Theft
Three board members of the Corona Community Volunteer Ambulance Corps were accused of stealing more than $325,000 from the Queens squad.
September 20, 2013, FridayBoardwalk Fire Erases Months of Rebuilding at Jersey Shore
Flames that began in an ice cream shop quickly engulfed businesses along a stretch of boardwalk rebuilt after Hurricane Sandy left the area devastated.
September 13, 2013, FridayNew York Today: Last Candidates Standing
What you need to know for Wednesday: Bill de Blasio's win, Eliot Spitzer's defeat and weather that feels like July.
September 11, 2013, WednesdayRemote-Controlled Model Helicopter Fatally Strikes Its Operator
A 19-year-old man was killed when a model helicopter that he was piloting in Calvert Vaux Park struck him in the head, the authorities said.
September 6, 2013, Friday1-Year-Old Boy Is Fatally Shot in Brooklyn
Antiq Hennis was in a stroller, crossing Livonia Avenue in Brownsville with his parents, when he was hit in the left side of the head by a bullet.
September 2, 2013, MondayNew York Today: Summer's End
What you need to know for Friday and the long weekend: the season's news notables, a mayoral poll and a subway disruption caused by kittens.
August 30, 2013, FridayNew York Today: Wild Things
What you need to know for Thursday: the city's love for wild animals, thunderstorms in the forecast and the return of a bar battered by Hurricane Sandy.
August 29, 2013, ThursdaySEARCH 503 ARTICLES BY RAVI SOMAIYA:
- Wine School: Get Out Your Corkscrew
- Op-Ed Columnist: The Unhealthy Meat Market
- Op-Ed Contributor: Why Nothing Is Truly Alive
- Well: Gadgets to Boost Bike Safety
- Silicon Valley's Youth Problem
- Essay: The Unhip, Unexpected Joys of Cruising
- Farm-to-Table Living Takes Root
- Op-Ed Columnist: Lunch on the Barricades
- Reaching My Autistic Son Through Disney
- State of the Art: A Wild Idea: Making Our Smartphones Last Longer


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Jennifer Hammock set "Bulbophyllum gracillimum" as an exemplar on "Bulbophyllum gracillimum (Rolfe) Rolfe".
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Ghost Prank.flv
prank to test brother's fear from ghost
prank to test brother's fear from ghost
Two panickers and one bad ass, not bad.
What's the worst that could happen by scaring people in Compton with a ghos...
ghost prank
extremly funny ghost prank
Japanese people go all out on their pranks
This is a pretty cool video. Cops are chasing down a car. During the enti...
I can only hope one day soon the dude at the end of the video gets his ass ...
there funny check out there youtube http://www.youtube.com/user/Prankvs...
Things really get interesting when the ghost pepper gets in his eye.
A few guys make a fake ghost to scare their friend who has an unusual fear ...
When someone signs you up for a prank show like this, they really hate you.
I totally pwned my bro with the classic ghost car screamer!
a talking skeleton on a bike will send anyone into shock
He will die in seven days.


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With its wide, ambling steps, sweeping front porch and circular greeting area, this ultra-modern Texas home offers a warm invitation to visitors.
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In keeping with classic Low Country cottages, the 2013 home boasts an elevated front porch, clad in durable garapa wood decking.
(7 photos)


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Movie Star Danson Joins Environmental Attack on Alaska
Today film star Ted Danson and Environmentalists join forces to defeat 35,000 Alaskan jobs and a $70 billion infusion supporting economic recovery and national security. We urge all Alaskans to join us for the hearing tonight. We issue a 'Call to Action'.Today we also provide a link to the Yukon's gas pipeline reference library.
Dave Harbour, Publisher, Northern Gas Pipelines
Northern Gas Pipelines | 2440 E. Tudor Rd. | PMB #463 | Anchorage | AK | 99507
Posted: November 9, 2010
More Latest News »


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Dining Room Furniture
Our dining room furniture makes every night an elegant fine dining experience. How about that inviting setting where the family can sit and share their day. At Critelli's Fine Furniture you decide! Whether you are dining in style while sitting at a classically grand table where only the finest china will do, or the modern stylish table that is perfect for dining or game night, our selection is sure to please.
Browse our Dining Room Furniture Categories:


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Microsoft Europe
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At Microsoft, our mission is to help people and businesses around the world realize their full potential. Our commitment to Europe supports this mission, and reflects our efforts to advance social and economic opportunity in the communities where we work, live and do business through innovative technologies and partnerships.
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Las Vegas Rodeo Party
Rusty and the sculptors are hired by a legendary rodeo champion to create an enormous sand sculpture for a party at the National Finals Rodeo in Las Vegas.
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Food Network's Restaurant Impossible Makeovers
See before and after photos of Robert Irvine's biggest restaurant transformations.
Master Your Cooking Skills
Learn the fundamentals of cooking with Cooking Channel's tips and videos.


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Ceo Reference:
Phillip Saulnier
Have you been looking for information on Phillip Saulnier? Lead411 provides data on him which include twitter, linkedin url, and biography. There is also the The Chimes, Inc. email addresses within the @chimes.org profile so Phillip Saulnier's email could be included. Phillip Saulnier is part of the The Chimes, Inc. which has its main offices in Baltimore, MD. Currently holds the post of CEO. You can find the company data on Lead411 under the Specialty outpatient clinics, nec industry.
Similar Companies:
A A Dermatology & Laser Ctr
Looking for company data regarding A A Dermatology & Laser Ctr's CEO or CFO? A A Dermatology & Laser Ctr is part of the Offices and clinics of medical doctors field and are located in the area of Annapolis, MD. Some of the helpful data that can be found on their Lead411 profile include A A Dermatology & Laser Ctr email addresses marked by the domain @aadermatology.com. Other information could contain cfo names, linkedin profiles, corporate contacts, and facebook profiles.
A Chatterjee Md, is in the Offices and clinics of medical doctors industry. Their main office can be found in Baltimore, MD, and they can be contacted through A Chatterjee Md email using the domain @, some important contact info like linkedin data, contacts for cfos, etc of which can be found on their Lead411 profile.
This member of the Offices and clinics of medical doctors industry is located in Baltimore, MD and you can find important details regarding significant company contacts on their Lead411 profile like linkedin, facebook and cfo details. The profile also contains A F Nazemi email addresses which have a domain of @.
Company Directory > The Chimes, Inc.


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- CindyHornsby
Cindy HornsbySales Associate/Realtor (8 years experience)- CindyHornsby
- (1 review)
Property Management
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Ratings & Reviews
- Highly likely to recommend
05/05/2011 - bloomfever2002Listed, but didn't sell my Single Family home in 2010 in North Little Rock, AR.
Cindy was our realtor when we listed our home and when we were looking for a new home. She was on top of it every moment. She took wonderful photos of our home and even gave us tips to make it more cozy and inviting to buyers. She held numerous open houses and when we had a showing she made sure we had feedback the next day. . She showed us homes with the requirements we wanted and always listened to us. Cindy was with us every step of the way and made it a stress free experience I would recommend her to everyone..
(We ended up taking our house off the market for personal reasons. I would hire Cindy again when we are ready to relist..definetly)… MoreLess
Response from Cindy


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After taking a look at the hardware at the heart of the Xbox One in my last column, I was reasonably impressed with the power and potential of Microsoft's entry to the next generation of console gaming.
As multi-media becomes the norm and we rely on several screens across a variety of devices for entertainment, information and communication; a box that attempts to tie everything together and serve as an all-encompassing media hub is an intriguing prospect.
However, despite its pretensions to become ''more than a games machine'', there's no escaping the fact that it will always be seen as one, and the quality and popularity of its games is what will ultimately decide its success.
First impressions are all important, especially when launching a new console - a ''killer app'' or must-have title can help it fly out of the blocks, while a succession of duds can leave a machine facing an uphill struggle. With that in mind, let's take a closer look at some of the early additions to the Xbox One's launch library:
Forza Motorsport 5. $109.
Long regarded as the best driving game on the market, the Forza series is a petrolhead's dream. The latest update features the same depth and playability you'd expect from a Forza game and delivers it with more style, speed and slickness than ever before.
Easily the best looking racer on any console, Forza 5 is a the perfect advert for the Xbox One's graphical capabilities, with photorealistic visuals that are almost indistinguishable from real life.
The only downside is a worrying focus on micro-transactions - with cold hard cash required to unlock some premium cars and features. These pay-to-play options are expected in freemium and mobile games, but coughing up $80 for a virtual car harder to swallow when you've already shelled out $100+.
A recent patch has re-balanced the game to be slightly less money-grubbing, but the move towards fleecing players at every turn is a worrying one.
Dead Rising 3. $109.
Capcom's zombie splatterfest returns as an Xbox One exclusive, and for the most part serves up more of the same tongue-in-cheek mayhem.
Once again you're required to scavenge a post-apocalyptic city for parts to cobble together outlandish weapons, as well as rescuing survivors and finding silly costumes along the way.
While it isn't quite as visually impressive as other next-gen titles, it still manages to pack in some wow factor by rendering hordes of undead monsters on a scale far beyond any of the earlier games.
Cutting a swathe through a writhing mass hundreds of zombies deep has never been so satisfying, especially when you're doing it dressed as a Rastafarian banana and using a rocket-powered lawnmower. Heaps of fun.
The best way to measure the step up from previous to current-gen is to compare the same title across platforms. If FIFA 14 as any example, this is one small step for gamers but one giant leap for the industry.
Graphics are noticeably sharper; movement is smoother and player animations more detailed and lifelike. Off the pitch, each individual fan in a crowd of thousands is individually rendered and reacts to match events independently.
The introduction of EA Sports' new Ignite engine makes FIFA 14 even more realistic with dynamic player collisions and intelligent off-the-ball runs.
The interface is largely the same as last year's edition but the presentation has been refined, gameplay tweaked and features modified to make this a high point for the franchise.
Factor in a Legends mode, exclusive to Xbox One, allowing you to add the likes of Pele, Bergkamp and Maradona to your Ultimate Team, and you have the definitive version of the best football game ever.
Battlefield 4. $98
Another of EA's cross-gen title that benefits hugely from improved technology, Battlefield 4 on Xbox One narrows the gap between the stripped down 360/PS3 versions of the game and the all-singing, all dancing PC edition.
Higher-resolution graphics and more detailed textures give everything a noticeably more realistic look, improved draw distances allow you to see enemies from miles away and the game's vast maps become even more tactical and strategic when populated by up to 64 players in every online match.
The single-player campaign is a little disappointing, with shoddy AI and weak dialogue making it feel like a slap-dash afterthought, but when the multiplayer component is so impressive, it's easy to overlook.
With the distinctly uninspiring Call of Duty: Ghosts the only other first-person-shooter on Xbox One so far, if you're looking for an next-gen FPS, Battlefield 4 will definitely give you more bang for your buck.
Ryse: Son of Rome
Arguably the most visually stunning game in the Xbox One's launch library, the Roman hack n' slash adventure Ryse is definitely one to fire up if you're looking to show your mates what your new console is capable of.
While the graphics are nothing short of jaw-dropping, unfortunately the gameplay isn't quite as impressive, with a basic combat system leading to a repetitive and samey experience that soon becomes a tedious button-basher.
The game's gruesome execution animations, while initially mesmerising, lose their lustre after the 500th limb has been hacked off.
On the plus side, a well-written story, decent voice acting and epic set pieces manage to keep you invested but Ryse definitely a case of style over substance.
- (Live Matches)
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Coughlin: 'Chance' Rogers might play
Despite developing a blood clot in his left leg a little more than a week ago, there is a chance New York Giants defensive tackle Shaun Rogers might play this season.
Giants coach Tom Coughlin said Tuesday that the 12-year-veteran got a second opinion about his injury, and the team has ''a ray of hope'' that Rogers will be able to get back on the field.
Rogers reported swelling in his leg two days after the Giants played their preseason opener against Jacksonville on Aug. 12. Tests revealed a blood clot, and Coughlin said Rogers wouldn't play this season because he would have to take blood-thinning medication.
Coughlin said Rogers is still taking medication, but the second doctor thought he could play.
''I'm not going to be able to give you all the medical stuff. He is on his medication, there's a chance that he could come back and play, is what we've been told,'' Coughlin said. ''We're just going to hang in there as long as we can. See if they can determine where he is and how fast he would be able to play and all that stuff.''
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Patent References 3037980 3480613 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase of hepatitis C virus Patent #: 6777395 Inventors
AssigneeApplicationNo. 10544575 filed on 02/06/2004US Classes:536/27.11, Preparing by cleaving nucleic acids or by attaching an N-heterocyclic base to a sugar ring536/27.2, The bicyclic ring system consists of a 1,3-diazine ring, which may be hydrogenated, fused to a five-membered N-hetero ring (e.g., purine isoesters like tubercidin, toyocamycin, sangivamycin, sparsomycin A, etc.)544/262The other cyclo in the bicyclo ring system is five-memberedExaminersPrimary: Crane, J. E.Attorney, Agent or FirmForeign Patent References
International ClassesC07H 19/14C07D 487/00 DescriptionFIELD OF THE INVENTION The present invention is concerned with a novel process for the preparation of 2'-C-branched ribonucleosides which are inhibitors of hepatitis C viral (HCV) polymerase useful for the treatment of HCV infection. BACKGROUND OF THE INVENTION 2'-C-Alkylribonucleosides have been described in the patent literature as inhibitors of HCV RNA-dependent RNA polymerase and thereby useful for the treatment of HCV infection. Reference is made to the following publications of internationalpatent applications which disclose branched-chain ribonucleoside inhibitors of HCV polymerase: WO 01/90121 (29 Nov. 2001) and WO 01/92282 (6 Dec. 2001) both assigned to Novirio Pharmaceuticals and Universita degli Studi di Cagliari; WO 02/32920 (25Apr. 2002) assigned to Pharmasset Limited; and WO 02/057287 (25 Jul. 2002) and WO 02/057425 (25 Jul. 2002) assigned jointly to Merck & Co. and Isis Pharmaceuticals. Synthetic approaches to 2'-C-branched ribonucleosides have previously been describedin the chemical and patent literature: FR 1521076 (12 Apr. 1968); U.S. Pat. No. 3,480,613 (25 Nov. 1969); GB Patent No. 1209654 (21 Oct. 1970); S. R. Jenkins et al. Carbohydrate Res., 166: 219-232 (1987); A. Matsuda et al., Chem. Pharm. Bull., 36:945-953 (1988); M. S. Wolfe et al., "A Concise Synthesis of 2'-C-Methylribonucleosides," Tetrahedron Lett., 42: 7611-7614 (1995); R. E. Harry-O'kuru et al., "A Short, Flexible Route toward 2'-C-branched Ribonucleosides," J. Org. Chem., 62: 1754-1759(1997); Y. Murai et al., "A Synthesis and X-Ray Analysis of 2'-C-, 3'-C-, and 5'-C-Methylsangivamycins," Heterocycles, 33: 391-404 (1992); J. Wolf et al., Synthesis, 773-778 (1992); and M. Gallo et al., "Synthesis of 2'-Modified Nucleotides," Molecules,5: 727-729 (2000). Although the synthetic methods disclosed in these references suffice to prepare small quantities of the desired branched-chain ribonucleosides, they suffer from low and variable yields in the key glycosylation step to elaborate thenucleosidic bond in a stereoselective fashion and therefore are not amenable from an economic perspective to scale-up for the production of kilogram quantities required for preclinical and clinical use. The present invention provides a novel process for the preparation of 2'-C-alkylribonucleosides which are inhibitors of HCV polymerase useful for the treatment of HCV infection. SUMMARY OF THE INVENTION This invention is concerned with a process for preparing 2'-C-alkylribonucleosides of structural formula I: ##STR00003## wherein R1 is C1-6 alkyl and B is a purine or pyrimidine nucleobase selected from the group consisting of cytosine, uracil, thymine, hypoxanthine, adenine, guanine, 7-deazaguanine, 7-deazaadenine,7-deaza-2,6-diaminopurine, and 7-deazahypoxanthine. DETAILED DESCRIPTION OF THE INVENTION The process of the present invention involves the preparation of a compound of structural formula I: ##STR00004## wherein R1 is C1-6 alkyl and B is a purine or pyrimidine nucleobase selected from the group consisting of cytosine, uracil, thymine, hypoxanthine, adenine, guanine, 7-deazaguanine, 7-deazaadenine,7-deaza-2,6-diaminopurine, and 7-deazahypoxanthine; comprising the steps of: (a) producing a compound of structural formula II: ##STR00005## wherein PG is a hydroxyl protecting group, by treating a compound of structural formula III: ##STR00006## with a sulfonylating or halogenating agent in a suitable organic solvent in the presence of base, wherein said base is added before, during, or after said treatment with said sulfonylating or halogenating agent; (b) producing acompound of structural formula IV: ##STR00007## wherein B' is optionally protected B, by contacting a compound of structural formula II: ##STR00008## with a nucleophile B' in a suitable organic solvent; and (c) removing the hydroxyl protecting groups PG and optional protecting groups in B' to afford a compound of structural formula I. In one embodiment of the process of the present invention, B is guanine, cytosine, adenine, or 7-deazaadenine. In a class of this embodiment, B is 7-deazaadenine. In another embodiment of the process of the present invention, R1 is methyl. In a class of this embodiment, B is 7-deazaadenine. Structural representations of the various nucleobases of the present invention are provided below: ##STR00009## The starting point for the process of the present invention is a compound of structural formula III: ##STR00010## wherein PG is a hydroxyl protecting group. PG may be an ester, a silyl ether or a benzyl ether protecting group. The benzyl ether protecting group may be substituted with one to two groups independently selected from halogen,cyano, methyl, nitro, and methoxy. Intermediate III wherein PG is an optionally substituted benzyl ether may be prepared according to methods described in PCT International Applications WO 02/057425 (25 Jul. 2002) and WO 02/057287 (25 Jul. 2002). One embodiment of an ester protecting group is a benzoate ester unsubstituted or substituted with one to two groups independently selected from halogen, cyano, methoxy, nitro, and methyl. In a class of this embodiment the substituted benzoateester is a p-methylbenzoate ester (p-toluoate ester). Silyl ethers which are useful to protect the sugar hydroxyls include, but are not limited to, trimethylsilyl ether (TMS ether), triethylsilyl ether (TES ether), triisopropylsilyl ether (TIPS ether),t-butyldimethylsilyl ether (TBDMS ether), and t-butyldiphenylsilyl ether (TBDPS ether). Benzyl ethers which are useful to protect the sugar hydroxyls include benzyl, 4-chlorobenzyl, 4-methoxybenzyl, and 2,4-dichlorobenzyl. Compounds of structural formula III wherein PG is an ester protecting group, such as an optionally protected benzoate, may be prepared according to the procedures depicted in Scheme 1. ##STR00011## An efficient preparation of Intermediate 1-2 wherein R1 is methyl and Rb is benzyl is described by M. Funabashi, et al., in Carbohydrate Research, Volume 44, page 275-283, 1975. The first step in the process of the present invention is the construction of the 1,2-anhydroribofuranose intermediate of structural formula II. The 1,2-anhydride (epoxide) functions as a glycosylating agent to provide the desired branchedribonucleoside in a stereoselective fashion. The diol to epoxide transformation is accomplished by treatment of a 1,2-diol of formula III with a sulfonylating agent or halogenating agent either in the presence of a base, such as an amine, amidine, orguanidine base, in a suitable organic solvent, or initially with a sulfonylating or halogenating agent in a suitable organic solvent and subsequently with a suitable base, such as a hindered alkali metal alkoxide, such as potassium t-butoxide. Theformation of the epoxide from the diol is carried out at a temperature of about -10 to about 50° C. Sulfonylating agents which are efficient in effecting the formation of the 1,2-anhydride include, but are not limited to, methanesulfonylchloride, trifluoromethanesulfonyl chloride, benzenesulfonyl chloride, p-toluenesulfonyl chloride, and the corresponding sulfonic anhydrides. Halogenating agents include thionyl chloride, oxalyl chloride, and hydrogen halide (HBr or HCl) in acetic acid. Embodiments of amine bases include triethylamine, pyridine, 4-(dimethylamino)pyridine (DMAP), N,N-diisopropylethylamine, and diisopropylamine; embodiments of amidine or guanidine bases include 1,5-diazabicyclo[4.3.0]non-5-ene and1,1,3,3-tetramethylguanidine. The diol to epoxide conversion is carried out in a suitable organic solvent such as methylene chloride, chloroform, 1,2-dichloroethane, ethyl acetate, isopropyl acetate (iPAc), tetrahydrofuran, benzene, toluene, diethylether, acetonitrile, N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMAC), and 1,3-dimethyl,3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU), and mixtures thereof. Alternatively, the base is added after reaction with the sulfonylating or halogenatingagent. The resulting epoxide is then treated at a temperature of about 15 to about 100° C. with the appropriately protected nucleobase nucleophile to afford the desired protected 2'-C branched ribonucleoside. When B represents 7-deazaadenine, 7-deazaguanine, or 7-deazahypoxanthine, the nucleosidic linkage is constructed by treatment of the epoxide of formula II with the metal salt (such as lithium, sodium, or potassium) of an appropriately substituted1H-pyrrolo[2,3-d]pyrimidine, such as an appropriately substituted 4-halo-1H-pyrrolo[2,3-d]pyrimidine or optionally protected 4-amino-1H-pyrrolo[2,3-d]pyrimidine, which can be generated in situ by treatment with an alkali hydride (such as sodium hydride),an alkali hydroxide (such as potassium hydroxide), an alkali alkoxide (such as potassium t-butoxide), an alkali carbonate or bicarbonate (such as potassium carbonate and sodium bicarbonate), or an alkali amide base (such as sodium hexamethyldisilazaneand lithium diisopropylamide) in a suitable anhydrous organic solvent, such as acetonitrile, diethyl ether, tetrahydrofuran, 1-methyl-2-pyrrolidinone, N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMAC), and mixtures thereof. The displacementreaction can be catalyzed by using a phase-transfer catalyst, such as TDA-1 or triethylbenzylammonium chloride, in a two-phase system (solid-liquid or liquid-liquid). The protecting groups in the protected nucleoside of structural formula IV are thencleaved following established deprotection methodologies, such as those described in T. W. Greene and P. G. M. Wuts, "Protective Groups in Organic Synthesis," 3rd ed., John Wiley & Sons, 1999. Introduction of a primary amino group at the 4-positionof the pyrrolo[2,3-d]pyrimidine nucleus can be effected by treatment of the 4-halo intermediate with alcoholic ammonia or liquid ammonia. These conditions will also cleave ester protecting groups at the 3- and 5-positions of the sugar residue. A7H-pyrrolo[2,3-d]pyrimidin-4(3H)one (7-deazaguanine) compound may be derived by hydrolysis of the 4-halo intermediate with aqueous base, such as aqueous sodium hydroxide. Again these conditions will cleave ester protecting groups at the 3- and5-positions of the sugar residue. If an optionally protected 4-amino-1H-pyrrolo[2,3-d]pyrimidine is used in the nucleophilic displacement reaction to generate the nucleosidic bond, the amine protecting group is then cleaved before, after, orsimultaneously with cleavage of the protecting groups on the sugar residue. Illustratively, when PG represents an ester protecting group and the 4-amino group on the nucleobase is protected as its N-phthalimide derivative, all three protecting groupsmay be cleaved simultaneously by treatment with ammonia or an alkylamine, such as n-butylamine, neat or in the presence of an alcoholic solvent, such as methanol and ethanol. In addition to protection as an N-phthalimide derivative, any nucleobase amino group may be protected as its amide (such as optionally substituted N-acetyl and N-benzoyl), carbamate (such as t-butyl, benzyl, 9-fluorenylmethyl, and allylcarbamate), and imine derivative [such as N-(N',N'-dimethylaminomethylene)amine, N-(methoxymethylene)amine, and optionally substituted N-benzylideneamine]. ##STR00012## When B represents the pyrimidine nucleobase uracil or thymine, their bis-O-trimethylsilylated derivatives may be employed as nucleophiles in the reaction with the epoxide of structural formula II. The silylated derivatives of the nucleobase maybe generated in situ with N,O-bis(trimethylsilyl)acetamide to effect silyl transfer to the nucleobase. When B represents cytosine, the N,O-bis(trimethylsilyl) derivative of N4-acetyl or N4-benzoyl-cytosine may be used as the nucleophile. Thecoupling reaction is carried out under the persilylation conditions of Vorbruggen described in Chem. Ber., 114: 1279 (1981) optionally in the presence of a Lewis acid, such as tin tetrachloride, zinc chloride, and trimethylsilyl trifluoromethanesulfonate(TMSOTf), in an organic solvent such as acetonitrile, tetrahydrofuran, diethyl ether, and methylene chloride. The cytosine amine protecting group (acetyl or benzoyl) is then cleaved by treatment of the derived nucleoside with methanolic ammonia, whichconditions will also cleave any ester protecting group on the sugar hydroxyls. When B represents adenine, silylated N6-acetyl or N6-benzoyladenine may be used as the nucleophile and the coupling reaction is carried out using the persilylation conditions of Vorbruggen above. The adenine amine protecting group(acetyl or benzoyl) is then cleaved by treatment of the derived nucleoside with methanolic ammonia, which conditions will also cleave any ester protecting group on the sugar hydroxyls. When B represents guanine, silylated 2-(acetylamino)-9H-purin-6-yl diphenylcarbamate may be used as the nucleophile and the coupling reaction is carried out using the persilylation conditions of Vorbruggen above. The guanine amine and hydroxylprotecting groups (acetyl and diphenylaminocarbonyl, respectively) are then cleaved by treatment of the derived nucleoside with methanolic ammonia or hydrazine hydrate, which conditions will also cleave any ester protecting group on the sugar hydroxyls. Representative experimental procedures utilizing the novel process of the present invention are detailed below. The following Examples are provided for purposes of illustration only and are not intended to limit the process of the presentinvention to the specific conditions for making the compound. By halogen is meant fluorine, chlorine, bromine, or iodine. By "Phth" is meant phthaloyl. The "squiggly" bond at the anomeric position of the furanose ring in the intermediate of structural formula III is intended to signify undefined stereochemistry at this stereogenic center. Thus, the process of the present invention is intendedto encompass the individual α- and β-anomers of the intermediate of structural formula III as well as all mixtures thereof as starting materials for the instant process. All X-ray patterns were obtained on a Philips 3100 diffractometer, using Cu Kα radiation, from 2° to 40° (2θ), using a collection time of 8 min. All DSC thermograms were taken on a TA 2920 Differential ScanningCalorimeter with a heating rate of 10° C./minute under a nitrogen atmosphere. The carbon-13 CPMAS nuclear magnetic resonance (NMR) spectra were obtained on a Bruker DSX 400WB NMR system using a Bruker 4 mm double resonance CPMAS probe whilespinning the sample at 15.0 kHz. The NMR experiments involved 1H/13C cross-polarization magic-angle spinning with variable-amplitude cross-polarization. A total of 512 scans were collected for the spectra with a contact time of 2.0 msec andrecycle delay of 5 s. The 13C spectrum is referenced to TMS using the carbonyl carbon of glycine (176.03 ppm) as a secondary reference. The thermogravimetric analysis (TGA) was performed on a Perkin-Elmer TGA-7 Thermal Analysis series at a heatingrate of 10° C./min with a nitrogen purge. EXAMPLE 1 4-Amino-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine (2'-C-methyl-7-deazaadenosine) (4-3) Preparation of Intermediates: 1. 2-C-Methyl-3,5-di-O-(p-toluoyl)-D-ribofuranose (2-2) ##STR00013## To a solution of 3-O-benzyl-1,2-O-isopropylidene-3-C-methyl-α-D-allofuranose (2-1) (for preparation, see Carbohydr. Res., 44: 275-283 (1975) (5.0 kg, 15.4 mol) and pyridine (3.7 kg, 46.2 mol) in 35 L of acetonitrile was added p-toluoylchloride (5.2 kg, 33.9 mol), and the reaction was heated at 50-55° C. for 12 h. A solution of 6.0 L (46.2 mol) of 48 wt % HBF4 (tetrafluoroboric acid) in 9 L of water was added at 50-55° C. After 2 h, 10 L of acetonitrile wasdistilled off, and 10 L acetonitrile was added. At 97% conversion, 10 L of acetonitrile was distilled off, and the reaction solution was cooled to 0-5° C. A solution of periodic acid (4.2 kg, 18.5 mol) in 10 L of water was added. After thereaction was aged for 30 min, 35 L of isopropyl acetate and 10 L of water were added. The organic phase was washed with 25 L of water followed by 20 L of aqueous NaHCO3, 15 L of 5% sodium thiosulfate in water, and 15 L of water. The isopropylacetate solution was concentrated to 10-15 L, and 40 L of methanol was added. The solution was cooled to 0° C. and diisopropylamine (0.78 kg, 7.7 mol) was added. After 2 d at 0° C., aqueous HCl (1N, 7.7 L) was added at 0-5° C.followed by 30 L of isopro acetate and 40 L of water. The organic phase was washed with aqueous 1N HCl, NaHCO3, and brine. The organic phase was dried through azeotropic distillation and treated with activated carbon. The carbon was removed byfiltration and the resulting solution was diluted to 75 L with isopropyl acetate and hydrogenated (45 psi, 50° C., 1.5 kg 10% Pd/C) for 24 h. The filtrate was concentrated to 15 L and 60 L of heptane was added at 50° C. The crystallineproduct was isolated by filtration washing with a 10 L of 20% isopropyl acetate in heptane. Drying afforded 4.03 kg of the desired diol 2-2. 1H NMR (CDCl3, 400 MHz): The ratio of α:β isomers in CDCl3 is about 5 to 1. For the major isomer: δ 7.95-7.90 (m, 4H), 7.26 (d, J=8.0 Hz, 2H), 7.17 (d, J=8.0 Hz, 2H), 5.53 (d, J=7.2 Hz, 1H), 5.22 (d, J=2.8 Hz,1H), 4.65-4.49 (m, 3H), 3.08 (d, J=3.2 Hz, 1H), 2.44 (s, 3H), 2.38 (s, 3H), 2.26 (s, 1H), 1.44 (s, 3H) ppm; for the minor isomer: δ 7.95-7.90 (m, 4H), 7.27 (d, J=8.0 Hz, 2H), 7.22 (d, J=8.0 Hz, 2H), 5.16 (d, J=5.6 Hz, 1H), 5.12 (d, J=5.6 Hz, 1H),4.66-4.49 (m, 3H), 3.54 (d, J=5.6 Hz, 1H), 2.91 (s, 1H), 2.43 (s, 3H), 2.40 (s, 3H), 1.44 (s, 3H) ppm. 13C NMR (CDCl3, 100 MHz): δ 166.6, 166.3, 165.9, 165.7, 144.6, 144.3, 143.8, 143.7, 129.9, 129.7, 129.3, 129.2, 129.1, 129.0, 127.0,126.9, 126.4, 126.2, 102.9, 100.8, 79.8, 79.2, 78.7, 76.9, 76.5, 76.4, 65.5, 64.0, 23.5, 21.7, 21.6, and 20.0 ppm. 2. 4-Phthalimido-7H-pyrrolo[2,3-d]pyrimidine (3-2) ##STR00014## To a 250 mL three-neck round bottom flask equipped with an overhead stirrer, nitrogen inlet, and thermocouple was charged 50 mL of dry N,N-dimethylacetamide followed by 5.0 g of 7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (3-1) [J. Davoll, J. Chem.Soc., 131-138 (1960)] and 11.6 g of phthalic anhydride. The resulting mixture was heated to 80° C. for 8 h and then cooled to 10° C. Water (40 mL) was added while maintaining the temperature below 15° C. The resulting slurry wasaged for 4 h, then filtered, and the filter washed with 20 mL of 1:1 (v/v) dimethylacetamide/water followed by 30 mL of water. The cake was sucked dry, then washed with 50 mL of ethyl acetate. The solid was dried at 40° C. under vacuum with anitrogen sweep to give 8.1 g of 4-phthalimido-7H-pyrrolo[2,3-d]pyrimidine (3-2); m.p. 276-277° C. 1H NMR (DMSO-d6, 400 MHz): δ 12.14 (s, 1H), 8.79 (s, 1H), 8.01 (dd, J=5.5, 3.1 Hz, 2H), 7.92 (dd, J=5.5, 3.1 Hz, 2H), 7.63 (dd, J=3.5, 2.4 Hz, 1H), 6.56 (dd, J=3.5, 1.8 Hz, 1H); 13C NMR (DMSO-d6, 100 MHz): δ 166.3, 154.2, 151.0, 145.2, 135.7, 132.0, 128.7, 124.4, 115.2, 100.1. ##STR00015## Step A: 1,2-Anhydro-3,5-di-O-(p-toluoyl)-2-C-methyl-α-D-ribofuranose (4-1) To a 72 L vessel was charged dry dichloromethane (32 L), triethylamine (3.0 L), and diol 2-2 (3.44 kg, 90 wt % pure). The mixture was warmed to 30° C., then methanesulfonyl chloride (0.79 L) was added over 40 min. After 1 h, the batchwas partitioned between pH 7 buffer (20 L) and methyl tert-butyl ether (44 L). The organic phase was washed with 1M aqueous NaCl (38 L) then switched to toluene by vacuum distillation followed by concentration to about 9 L. The resulting solution ofepoxide was used directly in Step B. Step B: 4-Phthalimido-7-[3,5-di-O-(p-toluoyl)-2-C-methyl-β-D-ribofura- nosyl]-7H-pyrrolo[2,3-d]pyrimidine (4-2) Tetrahydrofuran (5.4 L), sodium hydride (146 g of 60% dispersion in oil, unwashed), and N,N-dimethylacetamide (4 L) were charged to a 72 L flask and the suspension was cooled to 0° C. 4-Phthalimido-7H-pyrrolo[2,3-d]pyrimidine (3-2) (2.08kg) was added to the reaction while maintaining the temperature below 25° C. N,N-Dimethylacetamide (1.4 L) was added followed by the solution of the epoxide (2.75 assay kg) in toluene from Step A, and the reaction mixture was heated at50-90° C. for 9 h. After cooling to ambient temperature, ethyl acetate (19 L) and aqueous KH2PO.sub.4 (0.97 kg in 19 L of water) were added. The organic phase was washed with water. The resulting organic solution was solvent-switched totoluene by vacuum distillation (T<40° C.) to give a final volume of 10 L. Step C: 4-Amino-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyr- imidine (4-3) To the toluene solution from Step B at ambient temperature were added methanol (25 L) and n-butylamine (3.13 kg, 42.9 mol). The reaction mixture was aged at 64° C. for 24 to 30 h. The mixture was concentrated to about 9 L, and 9 L ofmethanol was added. The solution was concentrated to 9 L, and the resulting slurry was aged at 60° C. for 60 min. Toluene (13 L) was added over 1.5 h. The slurry was aged at 60° C. for another 2 h and then allowed to cool to ambienttemperature. The solid was filtered and the wet cake was washed with 9 L of 20% methanol in toluene then 9 L of 10% methanol in toluene. The solid was suction dried at ambient temperature under nitrogen to give 1.79 kg (94 wt % pure) of the titlenucleoside 4-3 as the toluene solvate. The X-ray powder diffraction pattern of the crystalline toluene solvate displayed characteristic diffraction peaks corresponding to d-spacings of 16.93, 12.16, 6.04, 5.95, 5.71, 4.62, 3.34, and 3.12 angstroms. The crystalline toluene solvate was also characterized by solid-state NMR spectroscopy. The carbon-13 CPMAS NMR spectrum exhibited signals with chemical shift values at 156.1, 150.0, 127.3, 124.3, 122.3, 121.1, 104.3, 99.6, 97.6, 90.9, 82.6,80.6, 73.3, 72.4, 71.0, 64.9, 64.0, 60.9, 20.3, and 17.9 ppm. The differential scanning calorimeter (DSC) curve for the crystalline toluene solvate exhibited a melting endotherm with a low temperature shoulder at approximately 200° C. Integration of this endotherm using a sigmoidal baseline fittinggave an onset temperature of 221.0° C., a peak temperature of 223.9° C., and an associated heat of 143 Joules/g. Thermogravimetric analysis (TGA) indicated a weight loss of about 3.0% from ambient temperature to about 233° C. Final Recrystallization or Hot Swish in 1-Propanol: A) The nucleoside 4-3 (30 assay g) was dissolved in 240 mL of 25% water in 1-propanol at 50° C. and the resulting solution was seeded. The water concentration was reduced to 2% by azeotropic distillation at reduced pressure whilemaintaining the volume constant with the addition of 1-propanol. The slurry was cooled to about 20° C. and the crystallized product was isolated by filtration to give 28.1 g of the unsolvated anhydrous crystalline form after suction drying atambient temperature. B) The nucleoside 4-3 (3.01 assay kg) was dissolved in 24 L of 2% water in 1-propanol and the slurry was heated at 60-65° C. for 4 h. After cooling to about 20° C., the crystalline solid was isolated by filtration togive 2.79 kg of the nucleoside as the unsolvated anhydrous crystalline form. The X-ray powder diffraction pattern of the crystalline anhydrate displayed characteristic diffraction peaks corresponding to d-spacings of 8.14, 6.11, 6.00, 5.96, 4.62, 4.06, 3.74, and 3.34 angstroms. The crystalline anhydrate was also characterized by solid-state NMR spectroscopy. The carbon-13 CPMAS NMR spectrum exhibited signals with chemical shift values at 157.7, 149.3, 147.0, 119.1, 102.8, 102.2, 90.7, 81.5, 79.3, 77.7, 66.5, and 19.9ppm. The differential scanning calorimeter DSC) curve for the crystalline anhydrate exhibited a melting endotherm with a peak temperature of 223.9° C., an onset temperature of 222.2° C., and an associated heat of 182 Joules/g. Thermogravimetric analysis (TGA) indicated a weight loss of about 0.2% from about 149° C. to about 237° C. High-performance Liquid Chromatography (HPLC) Assay Conditions: TABLE-US-00001 Column: Aquasil C18, 100 × 4.6 mm, 5 micron particle size Gradient: Time (min) MeCN 10 mM phosphate, pH 6.5 0 5% 95% 20 70% 30% 26 70% 30% Flow rate: 1 mL/min Detection: 220 nm Retention time 8.2 min for compound 4-3: * * * * * Other References


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Video: Richard Blanco Interview in it's entirety
BETHEL, Maine (NEWS CENTER) -- Inaugural poet Richard Blanco has written a new book based on his experiences leading up to the inauguration. Blanco's fame has risen significantly since he was chosen for the honor. He is the youngest, the first immigrant and the first openly gay Inaugural Poet. He joins Robert Frost and Maya Angelou in that honor.
"The book begins, obviously, with the moment I got the phone call," said Blanco while relaxing at his Bethel home.
"I had visions in my head of dancing at the ball, and I envisioned the ball to be a sit-down dinner, and at the ball having a little Salsa dance with the first Lady, perhaps sharing a drink with the President or having him tell me what he thought of the poem earlier in the day, but it was nothing like that," he said.
His poem, "One Today" was a hit. It launched him to a very busy two years of readings and appearances all over North America.
Blanco's new book, "For All of Us, One Today" hits book stores Tuesday.