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Download in domain names
all-free-download.com Free Vector graphic art, free photos, free icons, free website templates, psd graphic, photoshop brush, font, free download
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I was browsing through the code to eMule (0.26d), and noticed a couple potential problems with the use of UDP sockets with regards to security. It appears the IP of a UDP packet is taken to be trusted, however UDP packets can be easily forged to come from any source.
For example, based on the code from ClientUDPSocket.cpp, it would be possible to send "file not found" UDP packets to people trying to get a particular file, spoofed to be from various sources which have the file. (hope you understand what I mean by this).
The effect being, clients will drop the source and stop asking it for parts. (Through tests I know the client will drop the source, but correct me if Im wrong if this would eventually result in the source dropping the client from its queue).
This problem would seem to affect the following opcodes;
#define OP_REASKFILEPING 0x90 // <HASH 16> #define OP_REASKACK 0x91 // <HASH 16> #define OP_FILENOTFOUND 0x92 #define OP_QUEUEFULL 0x93
I haven't checked into this fully, but after a few tests, it would seem to be the case- let me know if you can think of a flaw in this theory. I have written a rough mod that sends a 'FILENOTFOUND' op to every source IP, spoffed to be from each IP (ie. 100 sources = 1000 spoofed packets), just to check if my theory was correct - but it didn't seem to have any effect - but this could be because of routers and filters etc. But when sending spoofed packets to myself, my client does drop the source.
If this is indeed a problem, a quick solution is to just turn off the UDP port. For the protocol, probably some kind of challenge response would be needed, - perhaps send a 'file ask' packet whenever you get a FILENOTFOUND packet just to be sure.
case OP_FILENOTFOUND: { theApp.downloadqueue->AddDownDataOverheadFileRequest(size); CUpDownClient* sender = theApp.downloadqueue->GetDownloadClientByIP(inet_addr(host)); //assumes the packet is not spoofed if (sender){ sender->UDPReaskFNF(); } else //ASSERT (false); //Need to double check these asserts to make sure it's running well. break; }
void CUpDownClient::UDPReaskFNF(){ m_bUDPPending = false; theApp.emuledlg->AddDebugLogLine(false,CString("UDP ANSWER FNF : %s"),GetUserName()); theApp.downloadqueue->RemoveSource(this); if (!socket) Disconnected(); }

subset: commoncrawl


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Dryden Home > Collections > Movies > X-38 > Movie #EM-0038-09 | |
X-38 research aircraft - second drop flight from NB-52B mothership |
Movie Number |
Movie Date |
Formats | 160x120 15-fps QuickTime Movie (2,892 KBytes) 320x240 30-fps QuickTime Movie (1,449 KBytes) 320x240 30-fps MPEG-1 Movie (4,867 KBytes) |
Still photos of this aircraft are available in several resolutions at http://www.nasa.gov/centers/dryden/multimedia/imagegallery/X-38/index.html |
Description |
This 32-second film clip shows the X-38 vehicle on its second test flight, dropping away for the NB-52B mothership and jettisoning the stabilizing drogue chute door. Included are several shots of the vehicle under its main parachute (parafoil) until it finally touches down on Rogers Dry Lake at Edwards Air Force Base, California. In the mid-1990's researchers at the NASA Dryden Flight Research Center, Edwards, California, and Johnson Space Center in Houston, Texas, began working actively with the sub-scale X-38 prototype crew return vehicle (CRV). This was an unpiloted lifting body designed at 80 percent of the size of a projected emergency crew return vehicle for the International Space Station. The X-38 and the actual CRV were patterned after a lifting-body shape first employed in the Air Force X-23 (SV-5) program in the mid-1960's and the Air Force-NASA X-24A lifting-body project in the early to mid-1970's. Built by Scaled Composites, Inc., in Mojave, California, and outfitted with avionics, computer systems, and other hardware at Johnson Space Center, two X-38 aircraft were involved in flight research at Dryden beginning in July of 1997. Before that, however, Dryden conducted some 13 flights at a drop zone near California City, California. These tests were done with a 1/6-scale model of the X-38 aircraft to test the parafoil concept that would be employed on the X-38 and the actual CRV. The basic concept was that the actual CRV would use an inertial navigation system together with the Global Positioning System of satellites to guide it from the International Space Station into the Earth's atmosphere. A deorbit engine module will fire to slow the vehicle and cause it to re-enter the atmosphere. Then a series of parachutes and a parafoil would have deploy in sequence to bring the vehicle to a landing, possibly in a field next to a hospital. Flight research at NASA Dryden for the X-38 began with an unpiloted captive carry flight in which the vehicle remained attached to its future launch vehicle, the Dryden B-52 008. There were four captive flights in 1997 and three in 1998, plus the first drop test on March 12, 1998, using the parachutes and parafoil. Further captive and drop tests occurred in 1999. Although the X-38 landed safely on the lakebed at Edwards after the March 1998 drop test, there had been some problems with the parafoil. Intermediate parafoil tests at the Army Yuma Proving Grounds in Arizona enabled the project to resolve these problems and resume flight research. In the drop tests, the X-38 vehicles were autonomous after air launch from the B-52. After they deploy the parafoil, they have remained autonomous, but there is also a manual mode that allows control from the ground. The X-38 vehicles (designated V131 and V132) are each 24.5 feet long. The actual CRV planned to be flown in space was expected to be 30 feet long. The X-38 program was cancelled in March 2002. |
Keywords | X-38; Dryden Flight Research Center; Johnson Space Center; NASA; Crew Return Vehicle; technology demonstrator; prototype; X-23; SV-5; X-24A; lifting body; Scaled Composites; Inc.; avionics; computer systems; parafoil; inertial navigation system; Global Positioning System; lakebed; U. S. Army; Yuma Proving Grounds; autonomous; manual mode; CRV; landing |
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NGE >> The Arts >> Music >> Archives and Organizations >> Georgia Music Hall of Fame |
Georgia Music Hall of Fame The Georgia Music Hall of Fame in Macon served for fifteen years as the state's official music museum. The 43,000-square-foot building was home to thousands of documents and artifacts,
History In 1978 Lieutenant Governor Zell Miller named a Senate Music Recording Industry Study Committee to explore ways to attract the music industry to Georgia. According to early committee records, this group, in conjunction with the Music Recording Industry Advisory Committee,
The Georgia Music Hall of Fame Awards evolved in the years after they were first presented. In 1980 a Posthumous category was added, followed by the Mary Tallent Pioneer Award in 1983 and a Group category in 1992. Instead of a small reception for a few invited guests, the annual awards ceremony was opened to the public, and Georgia Public Television began broadcasting it in 1983. By 2011 more than 100 performers, nonperformers, groups, and pioneers had been inducted and presented with a Tiffany crystal "Georgy" award. The Museum In the late 1980s a movement took shape to honor Georgia's musical legends. Under Zell Miller's leadership the legislature allocated $6.5 million for the project. The city of Macon offered to donate property for the new building, and the Georgia Music Hall of Fame Authority was created in 1991 to begin the project. Groundbreaking for the site was held in May 1994, and the building was officially opened on September 21, 1996. Celebrities in attendance included Little Richard, Mike Mills and Bill Berry of R.E.M., the Pips, Travis Tritt, and MTV vee-jay Martha Quinn, among others. Among the museum's permanent exhibits was Tune Town, a 12,000-square-foot area devoted to all types of Georgia music. Each style of music was represented in one of Tune Town's buildings, which included a rhythm and blues club, a chapel, a café, and "Backstage Alley," an area featuring people behind the scenes in the music industry (such as songwriters, producers, and attorneys). The museum also housed two interactive theater venues, the Gospel Chapel and the Gretsch Theater. Artifacts on display included unusual instruments, performance costumes, obsolete recording technology, instrument makers' tools, awards, photographs, and personal memorabilia of the artists themselves. Tune Town also contained a gallery that hosted traveling and temporary displays. Exhibitions have included Wade in the Water: African American Sacred Music Traditions (from the Smithsonian Institution Traveling Exhibition Service), Party Out of Bounds: Twenty-five Years of Athens Music, and Shootin' Stars: Music Photography of Kirk West, among others. In September 1999 the Hall of Fame expanded its exhibit space with the addition of the Billy Watson Music Factory. This area was designed specifically for children from prekindergarten through the fourth grade. The Music Factory encouraged children to explore the world of music, including the sounds and instruments of other countries, careers in music, families of instruments, and musical styles. The second floor of the museum housed the Zell Miller Center for Georgia Music Studies, a library and archive for students, scholars, and researchers. This area featured more than 1,000 books on general music, Georgia history, and Georgia musicians, as well as files on the artists featured in the exhibitions. In 2003 more than 48,000 schoolchildren visited the Georgia Music Hall of Fame with school groups, clubs, scout troops, and other organizations. As the decade progressed, however, the museum faced significant financial challenges, and attendance and revenues decreased. In 2010 the state legislature voted to cease funding for the museum, and the Georgia Music Hall of Fame Authority accepted bids from other cities interested in hosting the facility. None of the bids were deemed suitable, however, and the decision was made to close the museum in June 2011. The museum's collections were either returned to donors or deposited in archives around the state, with the bulk of the materials being sent to the library at the University of Georgia in Athens for storage. The archives at Georgia State University in Atlanta and the University of West Georgia in Carrollton also received artifacts, and the Tubman African American Museum and Allman Brothers Band Museum at the Big House, both in Macon, created displays for a small portion of the collection. Suggested Reading Candace Dyer, Street Singers, Soul Shakers, Rebels with a Cause: Music from Macon (Macon, Ga.: Indigo Publishing Group, 2008). Laura M. Botts, Georgia State University Updated 9/19/2011 |
Home | What's New | Index | Quick Facts | About NGE | Help | Contact A project of the Georgia Humanities Council, in partnership with the University of Georgia Press, the University System of Georgia/GALILEO, and the Office of the Governor.


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My wife and I recently spent the night (5/2/13)at this hotel and found the staff to be extremely friendly and most helpful. I wish I could remember the name of the young lady who checked us in as she deserves a thank you. The hotel itself is old, outdated and in need of a remodel (which it is undergoing as... More
- Also Known As:
- Howard Johnson o`Cairns Hotel Rocklin
- Howard Johnson o`Cairns Hotel
- Howard Johnson Rocklin
- Rocklin Howard Johnson
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- TripAdvisor is proud to partner with Wyndham, Orbitz, Expedia, Hotels.com, Travelocity, Booking.com, Tingo and Venere so you can book your Howard Johnson Inn & Suites Rocklin reservations with confidence. We help millions of travellers each month to find the perfect hotel for both holiday and business trips, always with the best discounts and special offers.


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Information contained on this page is provided by NewsUSA, an independent third-party content provider. WorldNow and this Station make no warranties or representations in connection therewith.
(NewsUSA/Girltrunks) - Bathing suit season. The words strike fear in the hearts of women of all sizes, conjuring images of teeny-weeny bikinis and the inevitable wardrobe malfunctions. With bottoms that ride down and tops that ride up, women truly get the short end of the stick when it comes to summer swimwear.Explore KFVS12.comAll content ©Copyright 2000 - 2013 WorldNow and KFVS, a Raycom Media Station. All Rights Reserved. For more information on this site, please read our Privacy Policy and Terms of Service. |


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For me, the appeal of the conversation pit is the sense of comfort and informality. I bought my purple velvet Chesterfield sofa because it's so pretty, but it's not exactly the place to cuddle up and watch TV. And my lifestyle doesn't really demand formal sitting/dining areas — I can even imagine dinner parties nestled in a conversation pit with a big wooden square serving as a tabletop.
Conversation pits were originally created by Modernist architects and designers looking to maximize space and horizontality in their interiors. Look at one of the first, and chicest, conversation pits in history: one designed by Alexander Girard and Eero Saarinen (images 1 & 2), warm and vibrant but also sleek, preserving the sightlines across the space. But from those lofty origins they seemed to go horribly astray, ending up in a fuzzy sea of shag carpeting (image 3).
But now I'm sensing the potential for a conversation pit comeback. The New Mexico architect Bart Prince has included conversation pits in at least a couple of his projects, creating a kind of organic, clutter-free futurism (image 4). And Maxwell often talks about the inspiration he's gotten from Terence Conran, whose House Book from 1974 emphasized liveliness and comfort over formality, and featured a few choice photos of casual — dare I say sexy? — conversation pits (image 5).
An actual pit is not really feasible for most of us, which is why my real object of desire is the Dr. Pitt sectional from Mitchell Gold Bob Williams — but it's roughly $7000 fully loaded, so for now it's just resting quietly in my Svpply, taunting me as my Chesterfield gently rejects me onto my non-shag carpet.
What do you think, ready for a comeback, or best relegated to history's dustbin?
1: Sarah Catherine Design; 2 Ouno Design; 3 Boing Boing; 4 Photo by Robert Reck for Architectural Digest; 5 Conran's House Book, via Apartment Therapy; 6 Mitchell Gold Bob Williams
I saw this monstrosity last weekend at Z Gallerie: http://www.zgallerie.com/p-10152-cloud-modular-sectional-chocolate.aspx
I'm not sure if it's about to take flight or swallow me whole, but I'm not interested in anything it's bringing to the table.


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St. Mary Parish teens earn awards
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Several members of the St. Mary Parish Teen Ministry in Riverside recently were named 2010 Vicariate IV Youth Leadership Award winners for their "commitment to the Church, the community and the mission of God."
Among those honored were Jimmy Mullen, Salvatore Flight, Katie Manika, Stephanie Rodriguez, Carolyn Paneral and Christine Manika.
The teens were honored on March 12 at a special awards banquet.
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Thank you all for your applications to the first Derby Mini-Maker Faire – we're thrilled with the quality of your applications and will be in touch within the week.
Our Maker application is now open exclusively to young people and educational organisations for the Young Makers element of our Maker Faire. The deadline for applications is 4th May.
Click here to go the the Young Makers Application form.
Other Makers who have missed the deadline, or if you like to support this event by volunteering or sponsoring, we would love to hear from you! Please get in touch with firstname.lastname@example.com if you would like to discuss your project.
If you want to go on the mailing list to keep in touch with progress for the Mini-Maker Faire – click here to give us your details.


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I really need some inspirational stories from you lovely ladies on the subject of being a single mama. How do you make it through the day? What keeps you going? What advice do you have? How do you do it?
Single Mama's
You are here
sometimes i wonder. but really im pretty happy that i have complete control over what happens to me and my kid and the way we live.
I spend as much time as possible outside, at the park, etc. It is a great way to meet other people, including other single mamas.
I focus on my children and my work. I make sure to tell myself often "Hey, one day at a time girl" and remind myself that my children are happy, healthy, well adjusted and strong. I love my independance and often, I am amazed at myself and what I am capable of.
I often sit back and think, "Wow, we are all ok and I am ok and I rock at this" and it gives me such a beautiful, calm feeling.
There are things that are hard for me. I hate nights alone, I guess when the children are all in bed, the quietness of being alone bugs me a bit.
All in all, as long my babes are well, I feel great.
Well, I've never had a kiddo and partner at the same time so it's like I have nothing to compare my situation to. But I find the following things really help:
-take advantage of friends and family that are willing to help out. Even if you don't want to leave your kid with them, they can occupy the kid while you get stuff done
-take care of your body, even just a few minutes every day to give yourself a good facewash. it's worth it to not deal with the low self-esteem crap
-go to ANY groups available to you. I go to a breastfeeding group every week and because of my single-mom status, there's a group available to me where you just sit around and do nursery rhymes with your kid. I'm going to get into that one soon.
-don't rush into a new relationship just for the comfort and security, because if it ends down the road you'll be in the same spot, thinking "how do I do this alone?"
I hope things work out for you :)
well, i have been a single mama for pretty much three years.. i focus on school, work and my girls. like another poster said, the toughest part is at night, laying alone and it being so quiet. many nights i wish i could have someone just to snuggle up to and tell me everything will be alright.. but then again i KNOW everything will be alright because I AM MAKING IT ALRIGHT! its an awesome and empowering feeling to have total control of what you are going to do, and not having to explain to someone else.
I'm enjoying being single right now. It's not the right time for me to be in a relationship and i don't have the time to devote to someone at the moment. It does get lonely at night but i get over it.
I've also become very picky when it comes to men since having N. It's sad but i think it's true for a lot of us...before i was a mama i'd be more likely to settle for someone less than what i wanted out of loneliness or whatever...now that i'm a mama it's an entirely different story. Someone i'm dating will be around my son and maybe eventually his father and i won't settle for N...he's going to have the best. It's not easy to find the man i'm looking for...he's out there...but i'd just rather be home with my little man, instead of out looking for one right now.
Someday it'll be the right time to date. Right now i like doing it on my own.
i love being a single mom. so mucht hat i'm even thinking of having a baby on my own sometime soon. there are hard times. i once had to set my son up with some toys in the bathroom so i could puke and watch him at the same time. but i felt so damn bad ass after making in through! You get to make all the decisions and the fun of being the go to person for your little one. you get to make the kind of life you like and want.
I never thought id say this, but I love being a single mother! Its the best thing thats ever happened to me. Yes, I have an involved BD who drives me up the wall and makes life difficult, but for the most part, I make my own decisions for me and my baby girl, and I love it. The most important thing for me was to find friends in the same sort of position. They have helped me out a lot, and keep me thinking as positively as possible, even when Im feeling really bad.
i was an uber single mom for my daughter's first 18 months -- practically no help at all ... ever. but for the last two years her dad has been very involved which changes thing significantly. it's easier, in many ways, but also more stressful -- more to negotiate, more uncertainty, less autonomy.
in that first period i often said that while i didn't get any breaks, i never expected any which actually seemed to be easier in a lot of ways. the days, my daughter's needs, etc., were all structured solely around us. i like that. it was super important to me to have other mom friends. single moms have also played significantly in the past while and i really appreciate the commonalities we share.
so, things i enjoy: not a lot of daily negotiating, free time to actually do things with (when in relationship i'm always struck by how much time is wasted/how little i get done), lots of kiddo snuggles (my daughter seems to thrive when i'm single), time for waxing (or other silly beauty rituals), picking up new skills/habits/hobbies.
there seems to be more pattern in my single life, which can be stifling, but also is my most productive time. i'm currently missing that quite a bit as i get further inmeshed in a relationship.
My daughter's nearly seven months old, and barring a brief reconcilation with her father, I've been single since day one.
When he left us while I was still pregnant, I really didn't think I could do it on my own. But after I got over the initial 'shock' of having a baby (which everyone goes through, single or not) and got into the swing of things, I felt much better about it. Now, when my partnered mama friends ask me "However do you cope alone?" I ask them "However do you make time for your partner?!" My days are full, and come the end of them I'm quite happy to curl up with a book, I don't miss having a boyfriend like I used to do when I was single & childless.
Sure, it has its downsides - I'm not too sure what to say to Lydia when she's older & asks about her dad, I don't get out on my own that often, and dating is a total minefield because I come with a (very cute) bit of 'baggage' these days :lol: but these are a pretty fair tradeoff for not being in an unhappy relationship with BD & I've taken to crossing my bridges as I come to them. Worrying about the future won't change it, so I'm really working on less worrying, and more having fun with my little girl.
much love


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I was just watching Motel Hell on AMC last night.
I'd hadn't watched it since I seen it new at the drive-in in '80-ish.
Anyway, I was quite let down watching it last night.
I always remembered it as shocking and scary.. with a bit of black humour.
Last night, it just seemed boring.
I wish I hadn't watched it.
It kind of ruined my memory of it.


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I finished my semester last week, so I am officially on summer break. I finally get some time to relax, and I plan to read some good books. I used to hate reading so this may come as shock. But this summer, I really want to curl up with a good book. I really enjoy books that are written well, have pictures or designs, or both. And no, I don't mean picture books!
Keep reading to see my picks for summer.
5. The Joy of Decorating by Phoebe Howard Oh I love decorating so this book is like a dream come true!
4. I Brake For Yard Sales by Lara Spencer This just looks like a summer read. I'm hoping it will give me tips to find the best deals at yard sales and thrift stores.
3. Marrakesh by Design by Maryam Montague The cover alone interests me to read this book. I love great photography and great design. I hope this is as good as it looks!
2. Cupcakes and Cashmere: A Guide for Defining Your Style, Reinventing Your Space, and Entertaining with Ease by Emily Schuman I follow the Cupcakes and Cashmere blog, so I can't wait for this book to come out this summer.
1. That Extra Half An Inch by Victoria Beckham This is full of beautiful photos and illustrations, as well as Victoria's thoughts on fashion.


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The deep freeze that has been in Tulsa for the past two weeks has left the area, and temperatures have rebounded, with the high, according to reports, reaching 73 degress on this date, which is quite a contrast to the bitter cold a few days earlier. There still is some ice/snow visible on the sand bars in the Arkansas River, and some pieces of ice also have been floating down the river. The 21st Street bridge now is closed, and the deck has been removed from two arches at the east end. Photograph taken January 5, 1984.
Click tabs to swap between content that is broken into logical sections.


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We were looking for a quiet getaway and found more than we could have hoped for. After spending they day in cedar key, Amber checked us in to our great room #5. Very clean lots of room, Amber let us know that Island pizza delivered in case we became so relaxed we did not want to go back out for... More
- Official Description (provided by the hotel):
- Spacious king suites with patios overlooking the water. Tiki bar, relaxing hammocks and ample lounge areas along the water. A community weber grill is available to all guests. Watch the sunrise and set from your room. ... more less
- Also Known As:
- Low-Key Hideaway Hotel
- Low-Key Hideaway Hotel Cedar Key


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pilu said:
You guys don't know what evolution is/how does it work and anything about the progress in our modern society.
Autism is on the rise because the term got a broader meaning and the diagnosis is better.
Also, as Uncommon said, in the "good old days" 40-70% of the people died in their first 6 years.
Hello Austrian coffee cake. So the all-knowing bastard child of a Hungarian child prostitute seeks to educate us now? Bored of injecting your testicles with coke?


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Posts Tagged 'benefits'
Good-for-Something Standardized Tests
May 23, 2008 in Personal Reflection
Tags: about, accomodate, assess, assessment, benefits, compensate, contrary, diligent, disagree, divergent, emphasis, encourage, evil, good, list, observant, quietly, sit, something, standardized, standardized tests, still, student, tests, things, varying, welcome
Whether or not standardized tests assess content knowledge or critical thinking, they certainly assess the following traits, with varying levels of emphasis.
Feel free to add to the list.
Student is able to sit still, quietly.
Student is able to follow instructions.
Student is diligent, and observant.
Student fixes own mistakes, or corrects self, when shown to be in the wrong.
Student can tell, after the fact, when said student has made a mistake.
Student has high tolerance for bureaucratic poppycock.
Student understands spoken and written English at a moderate level.
Student uses clues to figure out what answer the authority wants them to give.
Student individually compensates for any skills above that said student lacks.
As a last resort, student retakes test and tries retaining knowledge the second time around.
If school isn't meant to prepare students with content knowledge, but for life — as more than a few bloggers have proposed — then standardized assessments shouldn't assess students' knowledge, but assessable skills.
My take: There are two or three applications for these skills out in the real world.
Divergent or contrary opinions are not simply welcome; they are encouraged.
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Every day, we experience a thousand moments, each of those moments setting in motion a thousand slightly different possibilities in the future. When we make these choices, we are thrust toward another day's crossroads, where we have another thousand choices.
Given the infinite number of choices we make in a lifetime, why do we choose so many of the same routes and make just as many of the same mistakes as our parents and grandparents?
I plan to learn from their mistakes. Let's see how far I get.
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text: The RAM-111-247-3 RAM Mount Marine Grade Aluminum Mount, with Square Rail Clamp Base, consists of the 1.5 inch diameter ball and socket system with RAM Universal Rectangular 6.25 x 2 inch Plate. This mount is designed to be a universal mounting solution for large and heavy electronic devices, including GPS, CB Radios, Ham Radios and more. The hole pattern found on the rectangular plate will connect to a large variety of third party cradle, gimbal brackets and mounts. The mounting base is a perfect solution for mounting to the cabin frame work on a fork lift, or any other square post up to 3 inches square.


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Boost to economy and jobs with restoration
Published at 16:36, Tuesday, 23 October 2012
THE announcement of government funding to secure dozens of jobs has proved a major cause for celebration.
Those involved say the award of £1.25m to the Lakeland Arts Trust to help fund the restoration of the Windermere Steamboat Museum will have wide-ranging positive effects on the area.
The money is set to unlock around £9m in further investments and enable the trust to realise its ambitious vision for the museum.
The Regional Growth Fund Grant will in turn secure a £7.5m Heritage Lottery Fund grant as well as private investment, to be used to create a world-class tourist attraction.
The plans also form part of the Windermere Waterfront Programme, a regeneration project aimed at bringing in visitors by raising the profile of the area.
South Lakes MP Tim Farron was at the museum on Friday to celebrate the news, which he said would have a significant impact on the local economy.
He added: "You are going to have an absolutely fantastic and fascinating place open to the public, a really interesting tourist attraction.
"It will create more jobs locally and boost the number of people visiting the Lakes.
"It is important in terms of heritage but also for the economy – what it means for jobs is immense."
He said the power of the grant to unlock further employment opportunities was welcome news in tough economic times.
Mr Farron was involved in bringing the funding to the area and said it signalled the start of an exciting period for Windermere.
The funding now means the plans can be put into action and the £10m refurbishment of the museum can take place.
Mr Farron added: "The great thing about the RGF is they are careful about how they spend it – and they have a record of backing winners.
"You have to be very clear about what you will do with the money. It took a lot of work to get this but it is a good use of public money and it is going to be spent wisely."
And he described as "pretty impressive" the fact Lakeland Arts Trust were one of two South Lakes companies to receive funding, saying it meant the region was punching above its weight.
Burneside-based paper manufacturer James Cropper was also granted £3.15m to fund a biomass steam generating plant.
Published by http://www.walneylocal.co.uk
More Windermere news
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- Cumbria detective describes mother and daughter Windermere boat deaths as "an absolute tragedy" (1 comment)
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- CCTV appears to show man stealing charity collection box from Windermere pub
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- £1.25m will safeguard Lakes jobs
Evening Mail homepage
ENERGY FOR LIFE 5.1k WALNEY FAMILY FUN RUN
Did you enjoy the Energy For Life 5.1k Walney Family Fun Run?
• Click here to pledge to take part in next year's event on September 2, 2012
Handy links
- Historic fountain to benefit from grant
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- Library opening times
- Cumbria detective describes mother and daughter Windermere boat deaths as "an absolute tragedy" (1 comment)
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- Have your say...
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- Cumbria detective describes mother and daughter Windermere boat deaths as "an absolute tragedy" (1 comment)


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Wed November 23, 2011
13 Additional Students Charged In SAT Cheating Scandal
By editor
Additional students have been charged in an SAT cheating scandal on Long Island, New York. Thirteen students were charged Tuesday with being part of a scheme in which students paid other teens to take college entrance exams on their behalf. So far, 20 current and former students at three high schools have been implicated in the scandal.


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(13 Reviews) Read Reviews
Low Price Guarantee
Comment: This is a nice helmet at a sensible price. It is solidly made, amply padded etc. But I did pull one of the snaps completely apart just trying to remove the visor to replace it with a visor/face shield. That could have been stronger! I would have rated it a five but for that. I managed to solder the pop rivet type of male snap back together and am able to use the helmet. In general it is a dandy basic, do the job, conservatively styled helmet. Just my cup of tea. I would buy the version with the face shield to start with the next time.
Charles Wadsworth
Willcox, AZ
Comment: I am not a big expert on helmets, but the thing that absolutely works for me is the price and I hope i will never find out if it's as strong as other helmets. The only things that bothers me is the fact that the padding is too thick or the helmet is too shallow as a result it sits a bit high on your head.
O. Sarkissov "The Cynic"
Comment: While I personally prefer a full-face helmet to one of these chic scooter-style, open ones, it's a good buy for my passenger who keeps their face in my shoulder most of the time! DOT label is protected by a leather flap in the back of the helmet. Good quality and very affordable.
Angel of the Internet
California, USA
Comment: VERY GOOD QUALITY HELMETS. VERY FAST SHIPPING. VERY REASONABLE. I AM TOTALLY IMPRESSED. TERRY
Comment: These are good helmets at a great price. Bought one large for me and one small for my daughter and wife. We also bought the face shield which really keeps the wind out.
Martin Jansen
Appleton, WI
Comment: Light weight and cool even in the Texas sun. Love the flip up visor.
Thomas Smith
Comment: Excellent product. Lightweight, fits perfect. great product.
Philadelphia, PA
Comment: Great little helmet, came quickly in the mail and keeps my ears warm. Fits like a glove.
Comment: It's good. The Snaps on the full face shield are difficult to secure because the curvature of the shield doesn't match the helmet. I had to let the center snap go unfastened. But it is light weight and I like the easy lift of the shield. Much better than a bubble.
Comment: SUPER DEAL ON A GREAT FITTING HELMET. JUST FOLLOW THE MEASUREING DIRECTIONS ABOVE AND IT WILL FIT PERFECT. I BOUGHT TWO YOU CAN'T GO WRONG.
Comment: This is about the same price as an identical Bell Helmet I bought in 1966 ($20 then). I prefer this for several reasons over a full face - the weight, the ventillation and the simplicity. I wish they would make a silver version. I look too much like a cop. Granted there is more protection with a full face, and I don't like the edge of the beveled plastic shield that close to my neck. Still, I only commute and never get up to 65. It is nearly ideal and definitely worth the price.
Comment: Good fit, good price, good service. Just what I wanted in a helmet
Houston, TX


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This explains why Tyrion Lannister is so bitter (c.f. 3:35 until the end). Edit: apparently not Peter Dinklage, but instead some other little person who looks like Peter Dinklage.
So now I've processed One Christmas at a Time. It's not terrible. Mostly it's what you'd expect from a Jonathan Coulton Christmas record (I haven't heard enough of Roderick to say how typical it is for him). There's only one re-recording that I'm aware of (Christmas Is Interesting, from Smoking Monkey), and since I never much liked that in the original, it obviously doesn't do a whole lot for me, but Uncle John, at a minimum, is probably worth the price of admission and will end up permanently in my holiday rotation alongside Chiron Beta Prime. For ten bucks, you could do worse. I would, in fact, totally link in Uncle John, because I like the funky bass riff, but this shit is so fresh that it's apparently not up anywhere yet, but it's a song about your awful uncle (in the surly and mean and classless way, rather than the rapey way, which might be a little much for Coulton), so, you know, imagination or whatever.
A drone metal cover of MBV's 'Only Shallow'. Why the FUCK didn't anybody tell me about this before? As a special bonus, Nadja also does a version of Elliott Smith's 'Needle In The Hay':
My newfound obsession with Bonobo continues. This falls somewhere between downtempo electronica and modern chamber music.
Yeah, I picked the new one up after listening to the covers album a bunch of times and so far I really really like it.
Have I said you guys about the Asylum Street Spankers? I don't know whether they're still doing farewell shows (if you're in Austin, this is a thing you should probably find out, and shame on you for missing them when you had the chance if they aren't), but the rest of you should probably run out and buy some of their records anyway. All but one of them is available online (if you want Live, the last time I checked, you basically had to dig it out of eBay or an Amazon seller). Maybe the best performance of a song that like six people in history have ever bothered to record: One of my favorites, in the original, because I don't quite have the time to listen to all of the live performances: Guy Forsyth doing his thing (I prefer the album cut from Spanks for the Memories, but what are you gonna do?): Wammo's in this band as well, though he doesn't seem to have the stage presence I would have expected of him: Oh, and also Christina Marrs sang with them for pretty much the duration:
Hol Baumann. http://soundcloud.com/hol-baumann It's ... I don't know. IDM I guess. I'm not very good with electronica genre names. :P It's clicky, there are samples, it meanders, sometimes it's dancey but seems like it isn't or vice versa. Complex enough to be appealing, but not so much that it distracts from coding. Charles I liked your link. Makes me think of the Moon soundtrack but er, less soundtracky (more purely creative, less needing to create, sustain and direct tension). That was Clint Mansell, I believe.
This is really cool, whatever genre you want to call it. You might like the Bonobo tracks I posted on this page if you're into this kind of intricately arranged electronica.
Yep, already on my Mog list, courtesy of this thread I think. :) Hol Baumann has a few albums out, so the soundcloud isn't the end of those works.
I was recently reminded of the existence of Balkan Beat Box. This was a good thing, as they're awesome.
I think that after all that Kreaycommotion I started in the thread for dumb music I will tro to appease ye gods with some super skilled DJ's
It also feels a lot more like a Swans album than My Father Will Blah Blah. It's good to hear Jarboe again. Edit: I'm feeling album-of-the-year about it, but I haven't really listened to a lot of new music this year.
On that subject, I am diving back into everything I've bought this year in preparation for my unnecessary best albums of the year list. Going to be tough to winnow it down to ten.
Rubber Soul. I hit a like for L'oncle's 'concert for george' instance of google/record companies being bastards because it's a brilliant concert but I have no idea which song was being played. I remember sitting in a carpark and crying because George Harrison had died. I can see "in my life" is up next which I've always loved but I've spent an hour or so writing this, listening to the music and revisiting the concert for george and I'm happy.
After resurrecting them in my mind for another thread, I've been listening to Sunny Day Real Estate's How It Feels to Be Something On and it's a lot better than I even remember. Yay!
Boston. motherfuckers. the little plastic guitars are long gone. Toto is coming up next followed by celine "sit on a bus and make me enter a shit music competition will you?"Dion. PUT HEADPHONES ON
Really liking the new Deftones album. Koi No Yokan and Diamond Eyes have been a fantastic return to form.


text:
Find out how to collect your favorite items
{ object_type: 'Unknown',embed_type: 'image',embed_detail: 'http://myloc.gov/_assets/Exhibitions/EarlyAmericas/ExplorationsandEncounters/Assets/explore_t_125.Jpeg',embed_alt: 'Explorations and Encounters',thumbnail: {url: 'http://myloc.gov/_assets/Exhibitions/EarlyAmericas/ExplorationsandEncounters/Assets/explore_t_125.Jpeg',alt: 'Explorations and Encounters',height: '66',width: '125'} }
Christopher Columbus's voyages began a centuries-long series of encounters between peoples of the Americas and Europe. The Kislak Collection includes a selection of dramatic objects and records that reflect this complicated and extraordinary epoch. This section presents materials from the voyages of exploration of Christopher Columbus (1451–1506), Hernán Cortés (1485–1547), and Francisco Pizarro (ca. 1475–1541) and material about the natives of the Americas they encountered. It also features the Conquest of Mexico paintings, created in the seventeenth century, which depict the cataclysmic encounter between Cortés and the conquistadors and Moctezuma and his people.
View all items from Explorations and Encounters »
When Christopher Columbus arrived on the Bahamian Island of Guanahani (San Salvador) in 1492, he encountered the Taíno people, whom he described in letters as "naked as the day they were born." The Taíno had complex hierarchical religious, political, and social systems. Skilled farmers and navigators, they wrote music and poetry and created powerfully expressive objects. At the time of Columbus's exploration, the Taíno were the most numerous indigenous people of the Caribbean and inhabited what are now Cuba, Jamaica, Haiti, the Dominican Republic, Puerto Rico, and the Virgin Islands. By 1550, the Taíno were close to extinction, many having succumbed to diseases brought by the Spaniards. Taíno influences survived, however, and today appear in the beliefs, religions, language, and music of Caribbean cultures. Read more about Columbus and the Taíno »
View all items from Columbus and the Taíno »
In 1519, inspired by rumors of gold and the existence of large, sophisticated cities in the Mexican interior, Hernán Cortés (1485–1547) was appointed to head an expedition of eleven ships and five hundred men to Mexico. At that time the great empire of the Mexica—now known as the Aztecs—dominated much of Mesoamerica. Their capital, Tenochtitlán, had become such a splendid city that, according to records, it dazzled the Spaniards, exceeding anything they had seen before. Two years after the arrival of Cortés and his conquistadors, constant war and diseases new to the Americas had destroyed Tenochtitlán, and the Aztec Empire was no more. Read more about Cortés and the Aztecs »
View all items from Cortés and the Aztecs »
Francisco Pizarro (ca. 1475–1541) arrived in present-day northern Peru late in 1531 with a small force of about 180 men and 30 horses. Taking advantage of a civil war, he and his compatriots toppled the ruler, Atahualpa, in 1532. Over the next several decades the Spanish suppressed several Inca rebellions, achieving complete control by 1572. Pizarro's Spanish rivals assassinated him in 1541 in Lima, the city he had founded in 1535. Read more about Pizarro and the Incas »
View all items from Pizarro and the Incas »
After Spain's conquest of Mexico and other American lands, these events inspired books, paintings, and other historical and artistic records. In this section are materials illustrating these interpretations. Some of these items highlight the efforts of Bartolomé de las Casas (1474–1566), an early Spanish historian and Dominican missionary in the Americas, to persuade the Spanish Empire that indigenous peoples deserved humane treatment. Also featured are the spectacular Conquest of Mexico paintings created in the seventeenth century that capture the drama of the original encounter as imagined and interpreted by artists 150 years later. Read more about Interpreting the Conquest »
View all items from Interpreting the Conquest »
The Conquest of Mexico paintings are significant both artistically and historically. Painted in the seventeenth century, the eight detailed canvases tell the story of the 1521 Spanish conquest of the native Aztec people. These images highlight battles between the Spanish and the Aztecs, ceremonial encounters of the Spanish conquistador with the emperor Moctezuma, and other pivotal historic moments. The series ends with the dramatic "Conquest of Tenochtitlán" (the capital of the Aztec civilization, now Mexico City) and the capture of the last Aztec king.
View all items from Conquest of Mexico Paintings »
The conquest of Mexico by Hernán Cortés and the victories of other conquistadors in ensuing decades did not end conflict and dissension in the Americas. In this section, the exhibition provides examples of continued discord or disagreement, of cultural, political, and economic adjustment and accommodation, as well as examples of the skillful use Native Americans made of Spanish laws and courts to maintain their rights and win concessions for their people. Read more about Conflict and Accommodation »
View all items from Conflict and Accommodation »


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Updated 04/23/2012 08:02 PM
By: Zack Fink
There was relief for tenants in nearly one million rent stabilized apartments citywide Monday, as the U.S. Supreme Court declined to wade into the thorny issue of the city's longstanding rent protections. "This is a great victory. And it will keep New york affordable to those who wouldn't be able to afford to live here otherwise," said Manhattan Councilwoman Jessica Lappin.
The court was petitioned by Jim Harmon, who owns this brownstone on manhattan's upper West Side. The current rent laws prevent him from taking back any of his three rent-stabilized units.
In a surprise move, the Supreme Court asked the city and state to respond to the petition, but in the end the justices declined to hear the case, which centers on the city's housing crisis, which is defined as a vacancy rate below 5 percent.
In a statement, Harmon said, "Right now, there are 68,000 vacant apartments in the city. That is not an emergency by any definition. Because of rent stabilization, it will now continue to be difficult for us to keep our home of five generations."
"We understood that it was an uphill fight for the judges to accept to hear the case. We thought it was the right time for them to evaluate it," said Joe Strasburg of the Rent Stabilization Association. "We had rent regulation that was always deemed to be temporary in new York. 'Temporary' is defined over 50 years of permanency."
Tenant advocates welcomed the decision. They are pushing for a package of bills in Albany that would strengthen tenant protections.
"We fought a really hard fight last year to make sure that the laws were not allowed to sunset, when they were scheduled to sunset. And we now basically have the road cleared ahead to pursue strengthening tenant laws," said Maggie Russell-Ciardi of Tenants And Neighbors.
"To the extent the Supreme Court is saying the rent regulations will stand, I think that is good news for the State of New York. Rent regulations are very important to the tenants of New York, as you know," said Governor Andrew Cuomo.
For those who were hoping the Supreme Court would intervene, the Harmon case really did represent the last, great hope.
On the flip side, tenants and advocates are now confident that rent regulations will remain in place for at least a generation or more.


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Was: $60.00Now: $39.99
To view an item in an alternate color, place your mouse over a swatch above.
To view item in an alternate color, click on a swatch above.
Item #: 0321-05153-1046
This plus size denim jacket is a great new take on a classic closet staple. The bold colors will elevate any pant or dress outfit!
Women's Plus Size Colored Woven Denim Jacket - plus size jackets & plus size denim jackets in sizes 14/16W, 18/20W, 22/24W, 26/28W, 30/32W.
(based on 16 reviews)
of respondents would recommend this to a friend.
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By VaneRT
from Philly, PA
About Me Casual Dresser
Comments about Avenue Colored Woven Denim Jacket:
Great jacket for any occassion...comfortable, stylish, light-weight, and great color. I'm pleased. Very easy to wash and maintain.
I would buy this product again
By Hrdiva
from Richmond, CA
About Me Classic Dresser
I ordered this product on the Internet because the store had sold out of my size. I love it. I got the blue and the red and I love both colors. The only con is I wish they had more colors. Looks good with jeans and a pencil skirt very versatile!!!
Love This Jacket
By Susan
from Dallas, NC
I was so glad that I purchased this jacket. The color is beautiful and it looks great with jeans or dress slacks.
Perfect Jacket
By Nicole Vee
from Tampa, FL
I wish they hadnt sold out of my size in the other colors. would buy again.
By JoSlo what do you know
from Iowa
Love this jacket! It is comfortable, fashionable, and has flattering lines. I bought the red one and it is a beautiful color. I wore it the other day with a black and white polkadot top underneath with a pair of black pants and it was a gorgous pop of color. Cute!
By Joy
from Bklyn, NY
Buy it!!!
Cute jacket
By Teacher
from Wisconsin
Like this jacket very much! Comfy yet stylish. I got it on sale which is even better. I may swap out the buttons, don't really care for the rhinestone centers. Otherwise it's a great jacket.
Great jacket
Love Love, brought it in all colors. I thought the jacket ran small so I ordered a size bigger. I was wrong and had to exchange it for my correct size. Much better and it's faster if you can change it in the store itself, if not return it and order another one this way it comes to you faster.
By TOCKL
from Alabama
The blue is vivid and beautiful. This is a close fit jacket. I wear 18/20 sometimes a 22/24. I got the 22/24 and I won't be able to wear thick tops under it. I would recommend sizing up if you'll be wearing over sweaters.
Great color!
By T in Texas
from Dallas, Texas
Love the color! I am short so the sleeves were long but I cuffed them.
size chart - womanwithin


text:
New for 2013! Bridging the gap between traditional tents and tarp-style shelters, the Big Agnes Scout UL 2 provides a taut pitch with the use trekking poles (not included). Ideal for ounce-counters, this unique tent weighs in at well under 2 pounds.
New for 2013! An innovative option for 3-season camping, the Kelty Sonic 6 tent utilizes inflatable "AirPoles" in place of traditional poles. A double-action pump (included) makes it quick and easy to erect the tent and enjoy its 100.5 sq ft interior.
Tents with room for two or extra roominess for one
Spacious tents for large groups, base camping or car camping
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Designed especially for car and family camping (not for backpacking)
Minimalist designs and advanced materials make these the lightest offerings available
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NCI/PDQ® Health professionals: Childhood Non-Hodgkin Lymphoma Treatment (PDQ®) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
National Cancer Institute | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Last Modified: November 26, 2012 |
Fortunately, cancer in children and adolescents is rare, although the overall incidence of childhood cancer has been slowly increasing since 1975. 1 Children and adolescents with cancer should be referred to medical centers that have a multidisciplinary team of cancer specialists with experience treating the cancers that occur during childhood and adolescence. This multidisciplinary team approach incorporates the skills of the primary care physician, pediatric surgical subspecialists, radiation oncologists, pediatric medical oncologists/hematologists, rehabilitation specialists, pediatric nurse specialists, social workers, and others to ensure that children receive treatment, supportive care, and rehabilitation that will achieve optimal survival and quality of life. (Refer to the PDQ® Supportive and Palliative Care summaries for specific information about supportive care for children and adolescents with cancer.) Guidelines for pediatric cancer centers and their role in the treatment of children with cancer have been outlined by the American Academy of Pediatrics. 2 At these pediatric cancer centers, clinical trials are available for most of the types of cancer that occur in children and adolescents, and the opportunity to participate in these trials is offered to most patients/families. Clinical trials for children and adolescents with cancer are generally designed to compare potentially better therapy with therapy that is currently accepted as standard. Most of the progress made in identifying curative therapies for childhood cancers has been achieved through clinical trials. Information about ongoing clinical trials is available from the NCI Web site. Dramatic improvements in survival have been achieved for children and adolescents with cancer. 1 Between 1975 and 2002, childhood cancer mortality has decreased by more than 50%. For non-Hodgkin lymphoma (NHL), the 5-year survival rate has increased over the same time period from 45% to 88% in children younger than 15 years and from 47% to 77% for adolescents aged 15 to 19 years. 1 Childhood and adolescent cancer survivors require close follow-up because cancer therapy side effects may persist or develop months or years after treatment. (Refer to the PDQ® summary on the Late Effects of Treatment for Childhood Cancer for specific information about the incidence, type, and monitoring of late effects in childhood and adolescent cancer survivors.) Lymphoma (Hodgkin lymphoma and NHL) is the third most common childhood malignancy, and NHL accounts for approximately 7% of cancers in children younger than 20 years. 3 4 In the United States, about 800 new cases of NHL are diagnosed each year. The incidence is approximately ten cases per million people per year. The incidence of NHL observed in children and adolescents varies depending on age, histology, gender, and race. 3 Although there is no sharp age peak, childhood NHL occurs most commonly in the second decade of life, and occurs infrequently in children younger than 3 years. 3 NHL in infants is very rare (1% in Berlin-Frankfurt-Munster [BFM] trials from 1986 to 2002). 5 The incidence of NHL is increasing overall, which is accounted for because of a slight increase in the incidence for those aged 15 to 19 years; however, the incidence of NHL in children younger than 15 years has remained constant over the past several decades. 3 Childhood NHL is more common in males than in females, with the exception of primary mediastinal B-cell lymphoma, in which the incidence is almost the same in males and females. 3 6 A review of Surveillance, Epidemiology, and End Results (SEER) data on Burkitt lymphoma diagnosed in the United States between 1992 and 2008 revealed 2.5 cases/million person-years with more cases in males than in females (3.9:1.1). The incidence of diffuse large B-cell lymphoma increases with age in both males and females. The incidence of lymphoblastic lymphoma remains relatively constant across ages for both males and females. The incidence and age distribution of specific types of NHL according to gender is described in Table 1.
The incidence of NHL is higher in whites than in African Americans, and Burkitt lymphoma is more frequent in non-Hispanic whites (3.2 cases/million person-years) than in Hispanic whites (2.0 cases/million person-years). 7 Relatively little is known of the epidemiology of childhood NHL. However, immunodeficiency, both congenital and acquired (human immunodeficiency virus infection [HIV] or posttransplant immunodeficiency), increases the risk of NHL. Epstein-Barr virus (EBV) is associated with most cases of NHL seen in the immunodeficient population. 3 Although 85% or more of Burkitt lymphoma is associated with the EBV in endemic Africa, approximately 15% of cases in Europe or the United States will have EBV detectable in the tumor tissue. 8 NHL presenting as a secondary malignancy is rare in pediatrics. A retrospective review of the German Childhood Cancer Registry identified 11 (0.3%) of 2,968 newly diagnosed children older than 20 years with NHL as having a secondary malignancy. 9 In this small cohort, outcome was similar to patients with de novo NHL when treated with standard therapy. 9
With current treatments, more than 80% of children and adolescents with NHL will survive at least 5 years, though outcome is variable depending on a number of factors, including clinical stage and histology. 10 Prognostic factors for childhood NHL include the following:
In children, non-Hodgkin lymphoma (NHL) is distinct from the more common forms of lymphoma observed in adults. While lymphomas in adults are more commonly low or intermediate grade, almost all NHL that occurs in children is high grade. 1 2 3 The World Health Organization (WHO) has classified NHL on the basis of the following: (1) phenotype (i.e., B-lineage and T-lineage or natural killer [NK] cell lineage) and (2) differentiation (i.e., precursor vs. mature). 4 On the basis of clinical response to treatment, NHL of childhood and adolescence currently falls into the following three therapeutically relevant categories:
NHL associated with immunodeficiency generally has a mature B-cell phenotype and is more often of large cell than Burkitt histology. 5 Posttransplant lymphoproliferative diseases are classified according to WHO nomenclature as (1) early lesions, (2) polymorphic, and (3) monomorphic. 6 While the majority of posttransplant lymphoproliferative diseases are of B-cell phenotype, approximately 10% are mature (peripheral) T-cell lymphomas. 6 Other types of lymphoma, such as peripheral T-cell lymphoma, T/NK lymphomas, cutaneous lymphomas, and indolent B-cell lymphomas (e.g., follicular lymphoma), are more commonly seen in adults and occur rarely in children. Refer to the following PDQ® summaries for more information: Each type of childhood NHL is associated with distinctive molecular biological characteristics, which are outlined in the following table. The Revised European-American Lymphoma (REAL) classification and the WHO classification are the most current NHL classifications utilized and are shown below. 2 The Working Formulation is also listed for reference. The WHO classification applies the principles of the REAL classification and focuses on the specific type of lymphoma for therapy purposes. For the most part, the remaining categories do not pertain to pediatric NHL and are not shown.
Burkitt and Burkitt-like lymphoma/leukemia in the United States accounts for about 30% of childhood NHL and exhibits consistent, aggressive clinical behavior. 2 3 7 The overall incidence of Burkitt lymphoma is 2.5 cases per million person-years and is higher among boys than girls (3.9 vs. 1.1). 2 8 The most common primary sites of disease are the abdomen and the lymph nodes, especially of the head and neck region. 3 8 Other sites of involvement include testes, bone, skin, bone marrow, and central nervous system (CNS). The malignant cells show a mature B-cell phenotype and are negative for the enzyme terminal deoxynucleotidyl transferase (TdT). These malignant cells usually express surface immunoglobulin, most bearing surface immunoglobulin M with either kappa or lambda light chains. A variety of additional B-cell markers (e.g., CD20, CD22) are usually present, and almost all childhood Burkitt/Burkitt-like lymphoma/leukemia express CALLA (CD10). Burkitt lymphoma/leukemia expresses a characteristic chromosomal translocation, usually t(8;14) and more rarely t(8;22) or t(2;8). Each of these translocations juxtaposes the c-myc oncogene and immunoglobulin locus regulatory elements, resulting in the inappropriate expression of c-myc, a gene involved in cellular proliferation. 3 The distinction between Burkitt and Burkitt-like lymphoma/leukemia is controversial. Burkitt lymphoma consists of uniform, small, noncleaved cells, whereas Burkitt-like lymphoma is a highly disputed diagnosis among pathologists because of features that are consistent with diffuse large B-cell lymphoma. 9 Cytogenetic evidence of c-myc rearrangement is the gold standard for diagnosis of Burkitt lymphoma. For cases in which cytogenetic analysis is not available, the WHO has recommended that the Burkitt-like diagnosis be reserved for lymphoma resembling Burkitt lymphoma or with more pleomorphism, large cells, and a proliferation fraction (i.e., Ki-67[+] of 99%). 7 Studies have demonstrated that the vast majority of Burkitt-like or atypical Burkitt lymphomas have a gene expression signature similar to Burkitt lymphoma. 10 Additionally, as many as 30% of pediatric diffuse large B-cell lymphoma cases will have a gene signature similar to Burkitt lymphoma. 10 11 Despite the histologic differences, Burkitt and Burkitt-like lymphoma/leukemia are clinically very aggressive and are treated with very aggressive regimens. 12 13 14 15 Diffuse large B-cell lymphoma is a mature B-cell neoplasm that represents 10% to 20% of pediatric NHL. 2 3 16 Diffuse large B-cell lymphoma occurs more frequently during the second decade of life than during the first decade. 2 17 18 The WHO classification system does not recommend morphologic subclassification based on morphologic variants (e.g., immunoblastic, centroblastic) of diffuse large B-cell lymphoma. 19 Pediatric diffuse large B-cell lymphoma may present clinically similar to Burkitt or Burkitt-like lymphoma, though it is more often localized and less often involves the bone marrow or CNS. 16 17 20 About 20% of pediatric diffuse large B-cell lymphoma presents as primary mediastinal disease (primary mediastinal B-cell lymphoma). This presentation is more common in older children and adolescents and has been associated with an inferior outcome compared with other pediatric diffuse large B-cell lymphoma. 13 14 17 21 22 23 Primary mediastinal B-cell lymphoma is associated with distinctive chromosomal aberrations (gains in chromosome 9p and 2p in regions that involve JAK2 and c-rel, respectively) 22 23 and commonly shows inactivation of SOCS1 by either mutation or gene deletion. 24 25 Primary mediastinal B-cell lymphoma also has a distinctive gene expression profile in comparison with other diffuse large B-cell lymphoma, suggesting a close relationship of primary mediastinal B-cell lymphoma with Hodgkin lymphoma. 26 27 With the exception of primary mediastinal B-cell lymphoma, diffuse large B-cell lymphoma in children and adolescents differs biologically from diffuse large B-cell lymphoma in adults. The vast majority of pediatric diffuse large B-cell lymphoma cases have a germinal center B-cell phenotype, as assessed by immunohistochemical analysis of selected proteins found in normal germinal center B cells, such as the BCL6 gene product and CD10. 18 28 29 Unlike adult diffuse large B-cell lymphoma of the germinal center B-cell type, in which the t(14;18) translocation involving the immunoglobulin heavy-chain gene and the BCL2 gene is commonly observed, pediatric diffuse large B-cell lymphoma rarely demonstrates the t(14;18) translocation. 18 As many as 30% of patients younger than 14 years with diffuse large B-cell lymphoma will have a gene signature similar to Burkitt lymphoma. 10 A subset of pediatric diffuse large B-cell lymphoma cases were found to have a translocation that juxtaposes the IRF4 oncogene next to one of the immunoglobulin loci. diffuse large B-cell lymphoma cases with an IRF4 translocation were significantly more frequent in children than adults (15% vs. 2%), were germinal centerderived B-cell lymphomas, and were associated with favorable prognosis compared with diffuse large B-cell lymphoma cases lacking this abnormality. 30 Lymphoblastic lymphoma comprises approximately 20% of childhood NHL. 2 3 17 Lymphoblastic lymphomas are usually positive for TdT, with more than 75% having a T-cell immunophenotype and the remainder having a precursor B-cell phenotype. 3 31 Chromosomal abnormalities are not well characterized in patients with lymphoblastic lymphoma. As many as 75% of patients with lymphoblastic lymphoma will present with an anterior mediastinal mass, which may manifest as dyspnea, wheezing, stridor, dysphagia, or swelling of the head and neck. Pleural effusions may be present, and the involvement of lymph nodes, usually above the diaphragm, may be a prominent feature. There may also be involvement of bone, skin, bone marrow, CNS, abdominal organs (but rarely bowel), and occasionally other sites such as lymphoid tissue of Waldeyer ring and testes. Abdominal involvement is less than observed in Burkitt lymphoma. Low-stage lymphoblastic lymphoma may occur in lymph nodes, bone, testes, or subcutaneous tissue. Lymphoblastic lymphoma within the mediastinum is not considered low-stage disease. Involvement of the bone marrow may lead to confusion as to whether the patient has lymphoma with bone marrow involvement or leukemia with extramedullary disease. Traditionally, patients with more than 25% marrow blasts are considered to have leukemia, and those with fewer than 25% marrow blasts are considered to have lymphoma. It is not yet clear whether these arbitrary definitions are biologically distinct or relevant for treatment design.
Anaplastic large cell lymphoma accounts for approximately 10% of childhood NHL. 17 While the predominant immunophenotype of anaplastic large cell lymphoma is mature T-cell, null-cell disease (i.e., no T-cell, B-cell, or NK-cell surface antigen expression) does occur. The WHO classification system classifies anaplastic large cell lymphoma as a peripheral T-cell lymphoma. 4 Many view ALK-positive anaplastic large cell lymphoma differently than other peripheral T-cell lymphoma because prognosis tends to be superior to other forms of peripheral T-cell lymphoma. 32 All anaplastic large cell lymphoma cases are CD30-positive and more than 90% of pediatric anaplastic large cell lymphoma cases have a chromosomal rearrangement involving the ALK gene. About 85% of these chromosomal rearrangements will be t(2;5)(p23;q35), leading to the expression of the fusion protein NPM-ALK; the other 15% of cases are comprised of variant ALK translocations. 33 Anti-ALK immunohistochemical staining pattern is quite specific for the type of ALK translocation. Cytoplasm and nuclear ALK staining is associated with NPM-ALK fusion protein, whereas cytoplasmic staining only of ALK is associated with the variant ALK translocations. 33 There is no correlation between outcome and ALK translocation type. 34 In a series of 375 children and adolescents with systemic ALK-positive anaplastic large cell lymphoma, the presence of a small cell or lymphohistiocytic component was observed in 32% of patients and was significantly associated with a high risk of failure in the multivariate analysis, controlling for clinical characteristics (hazard ratio, 2.0; P = .002). 35 Clinically, systemic anaplastic large cell lymphoma has a broad range of presentations, including involvement of lymph nodes and a variety of extranodal sites, particularly skin and bone and, less often, gastrointestinal tract, lung, pleura, and muscle. Involvement of the CNS and bone marrow is uncommon. anaplastic large cell lymphoma is often associated with systemic symptoms (e.g., fever, weight loss) and a prolonged waxing and waning course, making diagnosis difficult and often delayed. Patients with anaplastic large cell lymphoma may present with signs and symptoms consistent with hemophagocytic lymphohistiocytosis. 36 There is a subgroup of anaplastic large cell lymphoma with leukemic peripheral blood involvement. These patients usually exhibit significant respiratory distress with diffuse lung infiltrates or pleural effusions and have hepatosplenomegaly. Most of these patients have an aberrant T-cell immunophenotype with frequent expression of myeloid antigens. Patients in this anaplastic large cell lymphoma subgroup may require more aggressive therapy. 37 38
The incidence of lymphoproliferative disease or lymphoma is 100-fold higher in immunocompromised children than in the general population. The cause of such immune deficiencies may be a genetically inherited defect, secondary to human immunodeficiency virus (HIV) infection, or iatrogenic following transplantation (solid organ transplantation or allogeneic hematopoietic stem cell transplantation [HSCT]). Epstein-Barr virus (EBV) is associated with most of these tumors, but some tumors are not associated with any infectious agent. NHL associated with HIV is usually aggressive, with most cases occurring in extralymphatic sites. 39 HIV-associated NHL can be broadly grouped into three subcategories: (1) systemic (nodal and extranodal), (2) primary CNS lymphoma, and (3) body cavitybased lymphoma, also referred to as primary effusion lymphoma. Approximately 80% of all NHL in HIV patients is considered to be systemic. 39 Primary effusion lymphoma, a unique lymphomatous effusion associated with the human herpesvirus-8 (HHV8) gene or Kaposi sarcoma herpesvirus, is primarily observed in adults infected with HIV but has been reported in HIV-infected children. 40 Highly active antiretroviral therapy has decreased the incidence of NHL in HIV-positive individuals, particularly for primary CNS lymphoma cases. 41 Most childhood HIV-related NHL is of mature B-cell phenotype but with a spectrum, including primary effusion lymphoma, primary CNS lymphoma, mucosa-associated lymphoid tissue (MALT), 42 Burkitt lymphoma, 43 and diffuse large B-cell lymphoma. NHL in children with HIV often presents with fever, weight loss, and symptoms related to extranodal disease, such as abdominal pain or CNS symptoms. 39 NHL observed in primary immunodeficiency usually shows a mature B-cell phenotype and large cell histology. 5 Mature T-cell lymphoma and anaplastic large cell lymphoma have been observed. 5 Children with primary immunodeficiency and NHL are more likely to have high-stage disease and present with symptoms related to extranodal disease, particularly the gastrointestinal tract and CNS. 5 PTLD represents a spectrum of clinically and morphologically heterogeneous lymphoid proliferations. Essentially all PTLD following HSCT is associated with EBV, but EBV-negative PTLD can be seen following solid organ transplant. 44 The WHO has classified PTLD into the following three subtypes: 6
The B-cell stimulation by EBV may result in multiple clones of proliferating B cells, and both polymorphous and monomorphous histologies may be present in a patient, even within the same lesion of PTLD. 45 Thus, histology of a single biopsied site may not be representative of the entire disease process. Not all PTLD is B-cell phenotype. 6 EBV lymphoproliferative disease posttransplant may manifest as isolated hepatitis, lymphoid interstitial pneumonitis, meningoencephalitis, or an infectious mononucleosis-like syndrome. The definition of PTLD is frequently limited to lymphomatous lesions (low stage or high stage), which are often extranodal (frequently in the allograft). 44 Although less common, PTLD may present as a rapidly progressive, high-stage disease that clinically resembles septic shock, which almost always results in death despite therapy. 46
Low- or intermediate-grade mature B-cell lymphomas, such as small lymphocytic lymphoma, MALT lymphoma, mantle cell lymphoma, myeloma, or follicular cell lymphoma, are rarely seen in children. The most recent WHO classification has identified pediatric follicular lymphoma and pediatric nodal marginal zone lymphoma as unique entities. 1 Pediatric follicular lymphoma is a disease that differs from the adult counterpart genetically and clinically. The genetic hallmark of adult follicular lymphoma, the translocation of t(14;18)(q32;q21), is typically not detectable in pediatric follicular lymphoma. Pediatric follicular lymphoma is more likely to be localized disease, in contrast to adult follicular lymphoma, which usually presents as disseminated disease. Cervical lymph nodes and tonsils are common sites, but disease has also occurred in extranodal sites such as the testis, kidney, gastrointestinal tract, and parotid. 47 48 49 50 The outcome of pediatric follicular lymphoma is excellent, and in contrast to adult follicular lymphoma, the clinical course is not dominated by relapses, if the BFM protocols for diffuse large B-cell lymphoma and BL are used. In pediatric follicular lymphoma, a simultaneous diffuse large B-cell lymphoma can frequently be detected at initial diagnosis but does not indicate a more aggressive clinical course in children. 48 49 Other diseases appear to reflect the disease observed in adult patients. For example, MALT lymphomas observed in pediatric patients usually present as low-stage (stage I or II) disease and are associated with H. pylori and require no more than local therapy involving curative surgery and/or radiation therapy. 51 Intralesional interferon-alpha for conjunctival MALT lymphoma has been described. 52 Other types of NHL may be rare in adults and are exceedingly rare in pediatric patients, such as primary CNS lymphoma. Due to small numbers, it is difficult to ascertain if the disease observed in children is the same as in adults and, therefore, it is difficult to determine optimal therapy. Reports suggest that the outcome of pediatric patients with primary CNS lymphoma (overall survival 70%80%) may be superior to that of adults with primary CNS lymphoma. These reports suggest that long-term survival can be achieved wit |
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High school wrestling: Mentor, Riverside win first dual tournament matches
January isn't a normally a month with any make-or-break matches, but wrestling's new addition has shaken up the schedule.
Mentor and Riverside made the most of their first appearances in the new state dual tournament at Mentor on Wednesday and will face each other in the second round next week. The Cardinals were dominant in a 51-13 win over Chardon, while the Beavers had a little tougher time in beating South, 36-29.
In the past, a team earned a spot in a different dual tournament based on its underclassmen district qualifiers, but the new format gives every team a shot in a statewide bracket.
"This week we have matches today, Thursday and Friday, so it makes it a little tough to make weight for Wednesday," Mentor coach Jim Capel said. "That could be good preparation for the state (individual) tournament, where they'll have to wrestle three days in a row."
It took until the second-to-last match for Riverside to secure its win over the Rebels.
South started quickly, gaining a 16-3 advantage. That's when Riverside went on a roll that ultimately clinched the victory. The Beavers won six straight matches, turning that early deficit into a 30-16 lead.
Brandon Leber (132) got things going by pinning South's Austin Wisdom in 4 minutes, 52 seconds. A technical fall by Nick Boggs (138) and another pin by Alex Ivary (145) put Riverside up for good.
"We've been a pretty good tournament team, but not as good when it comes to duals," Riverside coach Scott Blank said. "It was a little rough at the beginning, but we kind of expected that. I'm proud of the way the kids played, and it was good to start this whole new deal with a win."
South built its lead after Dylan Dusi (113) pinned Steve Hertzeg in the first period. Combined with a Joe Ducsay (126) technical fall and a forfeit at 106 pounds, the Rebels were looking good.
Toward the end of the evening, South's Cory Noble (182) earned a 5-3 decision over Chad Ely, and P.J. Svigel won a 12-4 major decision. That cut the deficit to 30-22 with two matches left, but the odds were stacked against the Rebels. Continued...
Evan Rosborough, arguably the best 220-pounder in the area, pinned Matt Schmidt in the first period, securing the win for the Beavers.
"The guys are really firing on all cylinders — it was fun to watch," Blank said. "We knew this was a good matchup on paper, and we had to have some guys wrestle at their best in order to come out with the win."
On the other side of the gym, Mentor had a 26-0 lead before Chardon won its first match. The Cardinals took eight of the 10 matches wrestled.
Mentor's Colin Kramer (113) had the fastest pin of the evening, finishing off Shane Scali in 23 seconds. Mike Wilkinson (106) also had a pin for the Cardinals, and Nick DeSanto (120) won a 17-2 tech fall over Anthony Tilocco.
"We've got a lot of young kids on the team who have really stepped it up," Capel said. Five of the 10 who wrestled are freshmen or sophomores. "Conditioning has been really important and realizing that the hard work pays off in the end."
Chardon's two wins came in Ric Rocazella's (145) 4-2 decision over Alex Piercy and Markus Znidarsic's 20-7 major decision over Aaron Wank at 182 pounds.
Because all four teams at Mentor had byes in the first round of the dual tournament, there were only two matches wrestled.
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00waste of MONEYJHunt"Green" is code for expensive. I think the Gov should be looking at a Return on Investment...like how many years do we have to occupy these buildings before the extra cost pays off? I'm in a "Green" building, it stinks, we don't even have light switches. They can pay hundreds for sensors but not a $1 for a switch? Yeah that makes sense.33739{ "Agree":"1","Funny":"1","Insightful":"1","Disagree":"-1","Offensive":"-1","Troll":"-1" }0OverdramaticSam BDon't be so dramatic. Those sensors cost about $25-$30 when bought individually. There is likely a discount for buying in bulk. The cost of the switch versus the sensor isn't the only ROI input. How much money does your building spend on utilities when no one is in the room? How much money does your building spend on maintenance staff turning switches on and off?33765{ "Agree":"1","Funny":"1","Insightful":"1","Disagree":"-1","Offensive":"-1","Troll":"-1" }33739
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Healthy Eating: Changing Your Eating Habits
The food you eat can affect your health and your risk for certain diseases. To eat healthier food, you may need to change some of your daily habits. You also may need to change some things in your environment. Your environment includes everything around you, like your home or the place you work.
You don't need to make huge changes to eat healthier. And you don't have to change your habits all at the same time. It's best to set small goals and change your habits a little bit at a time. Over time, small changes can make a big difference in your health.
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(Editor's note: See photos and story from the game in Thursday's Sampson Independent)
The Roseboro-Salemburg Middle boys held off a strong fourth-quarter comeback from Hobbton Tuesday afternoon to get the 55-47 victory and maintain their perfect season record for another day.
Todd Wheeler, coach of the middle school Leopards, said he was pleased with his team's intensity and their great defensive effort, but he also praised opponent Hobbton Middle, saying they were a good team that showed tenacity, particularly entering the fourth quarter.
"My guys played well," Wheeler said, "particularly on defense, and in the second and third quarters our shots really started falling. In the fourth quarter, Hobbton poured it on. They outscored us 19 to 10; they were on our tails."
Hobbton coach Jackson Temple was also pleased with his young Wildcats' performance, noting their great hustle.
"I'm really proud of these guys and the effort they put forth tonight and, really, every time they've played this year."
Temple also praised the R-S squad, noting how well they penetrated Hobbton's zone. "And they were also outstanding on the boards. It was a really good game."
Roseboro took the early lead at 16-8 after the first quarter and led 28-17 at the half.
Hobbton got in early foul trouble and had to bench some of their starting players, like Omar Farrior, until the final period.
"But I have to give a lot of credit to the guys who came off the bench and stepped up. They stayed with R-S. I was really proud of them," Temple said.
In the third, R-S had the hot hand, outscoring the Wildcats 17-8, but Faison and teammate Caleab Robinson returned for Hobbton in the fourth and helped lead the Hobbton team on a scoring run.
"They didn't miss a shot," Wheeler said of the Wildcats.
Faison, playing with four fouls, scored 10 points in the final period and Robinson added 6 more points. Teammate Walker Thompson hit a 3-pointer in the fourth as well.
Faison led scoring for Hobbton with a total 15 points; Robinson, 9; and Raquan Bryant, 10.
For R-S, Nyquan Murphy had 20 points to lead all scoring; Keshawn Bailey, 14; Akili Underwood, 6; and Tyquan Murphy, 4.
The win moves Roseboro-Salemburg to 3-0. They are open Thursday and face the Union Spartans Monday in a 4 p.m. game.
Hobbton Middle moves to 1-2. They play again Thursday when they host Union Middle at 4 p.m.