text:
A third of consumers will check out rival sites and apps if yours are too slow.
Tech performance firm Compuware made the infographic, which observes the behaviour and trends of mobile web and app users.
Mobile web browsing is set to overtake traditional desktops by 2014, while the average US smartphone user has downloaded 22 mobile apps, supporting global app downloads to pass 30bn apps last year.
However, 71 per cent of mobile web users expect the mobile web to be faster than their PCs, and one-third will go to a rival site if yours doesn't meet their needs.
Check out the infographic below.
* Like what ME does? Make sure you sign up to our free daily news headline service by clicking here. You can also follow/like us on Twitter and Facebook


text:
Funny pictures of animals – Irony- humor cute pictures
Photos and images are totally picked up on Net, including hilarious soccer pictures, cute dinosaur pictures, and the rest. If you are seeking Irony pic, figures or graphics we take them here for using. 2pep.com exclusively collect the highest quality Irony pics, figures or snapshots for our users to use. Our staff and users daily bring new Irony pictures, images or . Take them right here at 2pep.com the unique source for Irony on the website. I hope you like it. Click to see bigger size image.
It's ironic how many stupid people have access to the internet
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subset: commoncrawl


text:
My Profile
San Jose City Sightseeing Tour
San Jose, Costa Rica
My Rating
My Review
The city tour gives you a good overview of the history and beautiful culture to be had. The guide was VERY knowledgeable about the bare facts, quirks, and flavor of the town and the country!
My Photos


text:
Red Hot: Get Michelle Obama's look!
We know, we know. The inauguration was yesterday–practically months in fashion time, but we simply can't stop talking about Michelle Obama. Not only did the First Lady kill it with her bangs, the standout color of her dress had us swooning.
To be fair, we've always had a soft spot for crimson–we even have our very own shade: Frederick's Red! Even with, we forget how easy it is to tap into your inner bombshell on occasion (and we'd like to thank FLOTUS for reminding us). Are you ready to get fired up? Channel her ultra-confident look in or out of the house with our picks below:
Photo via Jason Merrit, Getty Images. Clockwise from top left: Lace Cutout Dress, Hollywood Dream Halter Corset, Lace Overlay Strapless Dress, and the Georgette Cami Doll Set.


text:
Chad Abshire
Staff Writer
WILLIAMSON — The United States Postal Service and National Association of Letter Carriers will "Stamp Out Hunger," food drive on Saturday, May 11.
The USPS calls it the nation's largest single-day food drive, saying that around 50 million Americans live at risk of hunger, or about one in six people. The USPS also states that food banks across the country continue to experience record demand for emergency food assistance.
To participate, simply leave a non-perishable food at your mailbox or wherever your letter carrier normally delivers their mail. Examples of non-perishable items you can donate include cereal, peanut butter, canned soups and vegetables, pasta and rice.
Across the nation, more than 175,000 letter carriers will collect food donations left at mailboxes in 10,000 communities and deliver them to food banks and other hunger relief organzations, like pantries and shelters.
Everything collected in Williamson will stay in the Tug Valley area to help needy families.
The drive has resulted in delivery of more than one billion pounds of donations to community food banks and pantries over the past 20 years.


text:
- MeetingsSchedule a meeting
- Special EventsPlan a special event
- WeddingsPlan a weddingEnd of tab panel
OffersFeatured OffersEnd of tab panel
About DoubleTreeAbout DoubleTreeEnd of tab panel
Stay one night with us and enjoy complimentary airport shuttle and hotel parking for up to 14 days.
Book your Tampa Bay summer vacation in advance and save. Explore beaches and more.
The DoubleTree Suites by Hilton Tampa Bay Hotel is an ideal setting for your Tampa Bay meetings, business and social events. With nearly 12,000 sq. ft. of flexible meeting space, we can accommodate any event, from small board meetings to waterfront weddings. Additional meeting and business amenities include a 24-hour business center, wireless internet, A/V equipment and expert catering services. So be our guest and enjoy all that sunny Tampa has to offer and plan your next event with us.


text:
Yesterday, the HR Examiner came out with Top 25 list of "Online Influencers" in Employment Law. Through a complex formula, it purports to show who people listen to about employment law online.
Unlike Groucho Marx who famously said "I don't care to belong to any club that will have me as a member", I'm thankful to be on the list and think the list is a useful starting point for people looking to see who's out there in the online world talking about employment law.
But the list has a obvious shortcoming — nearly two thirds of the list are made up of non-lawyers.
Back in 2009, I put together a list of 10 Twitter handles that you should consider following. That list, though, didn't focus just on employment lawyers. And, like many of you, I use the internet differently than I did back then and listen and interact with different people.
So, without using any fancy statistics or surveys, here is my brand new official list of ten employment lawyers who you should consider following online (besides, of course, yours truly. I can be found on Twitter @danielschwartz here):
This list is, of course, incomplete and, in many ways, arbitrary. People from 2009 that I continue to follow include @rossrunkel and @manpowerblawg. And people like @worklawyer or @chaifeldblum are certainly on my follow list too.
So perhaps I'll do a list of ten MORE people to follow sometime soon that will include some non-lawyers (like Stephanie Thomas) ; I'm certain I've left some people out. In the meantime, add your suggestions to the comments below.
*Photo Courtesy of Library of Congress
[View source.]
Published In: Labor & Employment Law Updates
DISCLAIMER: Because of the generality of this update, the information provided herein may not be applicable in all situations and should not be acted upon without specific legal advice based on particular situations.
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text:
A great drum for the Beginner, Intermediate or Seasoned drum circle player! Lifetime Shell Warranty!
Over the years our Authentic African drums were copied from size and construction to adinkra designs but never matched. Sweat shops are set every year in Indonesia, India, Pakistan or China to make drums for tourist trade, you can buy one in USA on Internet for about 30 dollars.


text:
National Cancer Institute®
Last Modified: August 1, 2002
AU - Kucher VV; Magura IS; Rozhmanova OM; Dolgaia EV; Pogorelaia NKh
[Modulation of voltage-gated sodium channels by recombinant
interferon-alpha2b in the human neuroblastoma cell line IMR-32]
SO - Ukr Biokhim Zh 2001 May-Jun;73(3):112-5
AD - Bogomolets Institute of Physiology, NAS of Ukraine, Kyiv.
Clonal human neuroblastoma cells imr-32 are a suitable model system for
studies of neuronal excitability modulation. The ability
interferon-alpha 2b "laferon" to modulate the mechanisms of electrical
activity was studied in whole-cell patch-clamped undifferentiated human
neuroblastoma cells IMR-32. It was shown that 1 h incubation of IMR-32
cells at 37 degrees C in medium with laferon (600 U/ml) exerted changes
in voltage-dependent properties of Na(+)-channels. The results of the
present study demonstrate that laferon decreased of Na(+)-channels
sensitivity to changes of membrane potential leading of IMR-32 cells
electrical excitability decrease.
AU - Yazawa T; Ito T; Kamma H; Suzuki T; Okudela K; Hayashi H; Horiguchi H;
Ogata T; Mitsui H; Ikeda M; Kitamura H
Complicated mechanisms of class II transactivator transcription
deficiency in small cell lung cancer and neuroblastoma.
SO - Am J Pathol 2002 Jul;161(1):291-300
AD - Department of Pathology, Yokohama City University School of Medicine,
Kanagawa, Japan. firstname.lastname@example.com
Small cell lung cancer (SCLC) and neuroblastoma (NB), the most
aggressive adult and infant neuroendocrine cancers, respectively, are
immunologically characterized by a severe reduction in major
histocompatibility complex (MHC) that is indispensable for anti-tumor
immunity. We had reported that the severe reduction of MHC in SCLC was
caused by a deficient interferon (IFN)-gamma-inducible expression of
class II transactivator (CIITA) that is known as a very important
transcription factor for IFN-gamma-inducible class II and class I MHC
expression (Yazawa T, Kamma H, Fujiwara M, Matsui M, Horiguchi H, Satoh
H, Fujimoto M, Yokohama K, Ogata T: Lack of class II transactivator
causes severe deficiency of HLA-DR expression in small cell lung cancer.
J Pathol 1999, 187:191-199). Here, we demonstrate that the reduction of
MHC in NB was also caused by a deficient IFN-gamma-inducible expression
of CIITA and that the deficiency in SCLC and NB was caused by similar
mechanisms. Human achaete-scute complex homologue (HASH)-1, L-myc, and
N-myc, which are specifically overexpressed in SCLC and NB, bound to the
E-box in CIITA promoter IV and reduced the transcriptional activity.
Anti-sense oligonucleotide experiments revealed that overexpressed L-myc
and N-myc lie upstream in the regulatory pathway of HASH-1 expression.
The expression of HASH-1 was also up-regulated by IFN-gamma. Our results
suggest that SCLC and NB have complicated mechanisms of
IFN-gamma-inducible CIITA transcription deficiency through the
overexpressed HASH-1, L-myc, and N-myc. These complicated mechanisms may
play an important role in the escape from anti-tumor immunity.
AU - Greenwood JM; Dragunow M
Muscarinic receptor-mediated phosphorylation of cyclic AMP response
element binding protein in human neuroblastoma cells.
SO - J Neurochem 2002 Jul;82(2):389-97
AD - Department of Pharmacology, Faculty of Medicine and Health Science,
University of Auckland, Auckland, New Zealand.
This study describes the effect of signalling through muscarinic
acetylcholine receptors on two transcription factors implicated in
long-term synaptic plasticity and memory formation, EGR1 and the cyclic
AMP response element binding protein (CREB). In SK-N-SH neuroblastoma
cells, treatment with the cholinergic agonist carbachol led to maximal
induction of EGR1 1 h after stimulation. This was preceded by the
phosphorylation of CREB, which peaked as early as 5 minutes after
carbachol treatment. The levels of both EGR1 and phosphorylated CREB
(pCREB) slowly decayed over 4-8 h. CREB phosphorylation and EGR1
induction showed similar sensitivity to carbachol concentration, with
EC(50) values in the range of 1-10 microM, and the changes in both
transcription factors were blocked by the muscarinic antagonist
atropine. As has been described elsewhere, EGR1 induction was dependent
on activation of p42/44 MAP kinase, as it was blocked by the MEK
inhibitor U0126. However, CREB phosphorylation by carbachol was largely
unaffected by MAP kinase blockade. As both CREB phosphorylation and EGR1
induction have been linked to long-term potentiation and some forms of
memory consolidation, these results may implicate CREB and EGR1 in
independent or partially independent cholinergic signalling pathways
involved in memory processes.
AU - Wang H; Yeo SL; Xu J; Xu X; He H; Ronca F; Ting AE; Wang Y; Yu VC; Sim
Isolation of streptonigrin and its novel derivative from Micromonospora
as inducing agents of p53-dependent cell apoptosis.
SO - J Nat Prod 2002 May;65(5):721-4
AD - Medicinal and Combinatorial Chemistry Laboratory, Lead Discovery Group,
Microbial Collection, Institute of Molecular and Cell Biology, 30
Medical Drive, Singapore 117609, Singapore.
Streptonigrin (1) and its novel natural derivative
7-(1-methyl-2-oxopropyl)streptonigrin (2) were isolated from an
actinomycete strain, Micromonospora sp. IM 2670. The inductions for 1
and 2 are more potent in the human neuroblastoma SH-SY5Y cells that
contain wild-type p53 than in SH-SY5Y-5.6 cells that overexpress a
dominant negative mutant of p53, thus suggesting that they induce
apoptosis through a p53-dependent pathway.
AU - Combaret V; Audoynaud C; Iacono I; Favrot MC; Schell M; Bergeron C;
Puisieux A
Circulating MYCN DNA as a tumor-specific marker in neuroblastoma
SO - Cancer Res 2002 Jul 1;62(13):3646-8
AD - Centre Leon Berard, 69008 Lyon, France.
MYCN oncogene amplification is an established indicator of the
aggressiveness of neuroblastomas; it is used internationally for
stratifying patients for therapy. The present study shows that high
levels of MYCN DNA sequences are present in the peripheral blood of
patients with MYCN-amplified neuroblastomas. Circulating MYCN DNA may be
a powerful and noninvasive prognostic marker at the time of diagnosis.
Furthermore, preliminary data strongly suggest that the release of MYCN
sequences in the peripheral blood is an early process in disease
progression, permitting us to propose this novel marker for the
follow-up of patients after chemotherapy.
AU - Sepe PS; Lahousse SA; Gemelli B; Chang H; Maeda T; Wands JR; de la Monte
Role of the aspartyl-asparaginyl-beta-hydroxylase gene in neuroblastoma
cell motility.
SO - Lab Invest 2002 Jul;82(7):881-91
AD - Department of Medicine, Rhode Island Hospital, Brown Medical School,
Providence, Rhode Island 02903, USA.
Aspartyl (asparaginyl) beta-hydroxylase (AAH) is overexpressed in
various malignant neoplasms, and high levels of immunoreactivity mainly
occur in infiltrating or metastasized tumors. In addition, AAH is
abundantly expressed in normally invasive placental trophoblastic cells.
These observations led to the hypothesis that AAH may have a role in
motility and aggressive behavior of tumor cells. The present study
demonstrates that AAH is overexpressed in primary human malignant
neuroectodermal tumors, including medulloblastomas and neuroblastomas,
and that AAH expression is at a low level or undetectable in the normal
mature brain. In the Sy5y neuroblastoma cell line, endogenous expression
of the approximately 86-kd AAH protein was demonstrated by Western blot
analysis, and immunoreactivity predominantly localized to the cell
surface by immunocytochemical staining and FACS analysis. Sy5y cells
that were stably transfected with the human AAH cDNA had increased
levels of proliferating cell nuclear antigen and Bcl-2, and reduced
levels of p21/Waf1 and p16. In addition, increased AAH expression
enhanced Sy5y cell motility, whereas antisense oligodeoxynucleotide
inhibition of AAH significantly reduced Sy5y cell motility and increased
the levels of p21/Waf1 and p16. The findings suggest that AAH
overexpression contributes to the malignant phenotype of neuroectodermal
tumor cells by increasing motility and enhancing proliferation,
survival, and cell cycle progression. Because AAH expression is at a low
level or undetectable in normal brain, the AAH gene may be a target for
treating primitive neuroectodermal tumors.
AU - Chamberlain MC
Treatment of intracranial metastatic esthesioneuroblastoma.
SO - Cancer 2002 Jul 15;95(2):243-8
AD - Department of Neurology, University of Southern California, Norris
Comprehensive Cancer Center and Hospital, Los Angeles, California
90033-0804, USA. firstname.lastname@example.com
BACKGROUND: Esthesioneuroblastoma (ENB) is an uncommon tumor that may
metastasize to the central nervous system (CNS). To the authors'
knowledge there is no current consensus regarding treatment. The current
study was conducted to determine the toxicity and response rate of
combined modality therapy in the treatment of patients with ENB
metastatic to the brain. METHODS: Six patients (2 men and 4 women)
ranging in age from 47-61 years (median age, 53.5 years) with ENB had
clinical and neuroradiographic evidence of CNS metastases (brain
parenchyma in 6 patients and leptomeningeal metastases in 3 patients).
CNS-directed therapy included radiotherapy (to the brain in three
patients and to the spine in two patients) and chemotherapy (systemic in
six patients and regional in three patients). Systemic chemotherapy was
comprised of carboplatin, lomustine, and vincristine administered every
2 months. Patients were evaluated by neuroradiographic and neurologic
examination every other month. RESULTS: Between 1-6 cycles of systemic
chemotherapy were administered (median, 4.5 cycles). and 6-19 cycles of
regional chemotherapy were administered (median, 17 cycles). Toxicity
included aseptic meningitis (three patients), radiation enteritis (one
patient), and > or = Grade 3 (according to the National Cancer Institute
Common toxicity Criteria) myelosuppression (four patients). Two patients
required hospitalization for neutropenic fever and two patients required
a transfusion (platelets in two patients and red blood cells in one
patient). No treatment-related deaths were reported. A partial response
was achieved in four patients, and two patients demonstrated progressive
disease. The median duration of response was 9 months (range, 2-12
months). Overall survival ranged from 3-13 months (median, 10.5 months).
The cause of death was progressive parenchymal brain disease in three
patients, systemic disease in two patients, and leptomeningeal disease
in one patient. CONCLUSIONS: In the small cohort of patients in the
current study, combined modality therapy was found to have modest
toxicity and palliative efficacy. Copyright 2002 American Cancer
Society.DOI 10.1002/cncr.10679
AU - Vandesompele J; Speleman F
A brief commentary on "Chromosomal aberrations in neuroblastoma cell
lines identified by cross species color banding and chromosome
SO - Cancer Genet Cytogenet 2002 Jun;135(2):196
AU - Casciano I; Mazzocco K; Boni L; Pagnan G; Banelli B; Allemanni G;
Ponzoni M; Tonini GP; Romani M
Expression of DeltaNp73 is a molecular marker for adverse outcome in
neuroblastoma patients.
SO - Cell Death Differ 2002 Mar;9(3):246-51
AD - Laboratory of Population Genetics, Istituto Nazionale per la Ricerca sul
Cancro (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy.
The p73 gene is a p53 homologue which induces apoptosis and inhibits
cell proliferation. Although p73 maps at 1p36.3 and is frequently
deleted in neuroblastoma (NB), it does not act as a classic
oncosuppressor gene. In developing sympathetic neurons of mice, p73 is
predominantly expressed as a truncated anti-apoptotic isoform
(DeltaNp73), which antagonizes both p53 and the full-length p73 protein
(TAp73). This suggests that p73 may be part of a complex tumor-control
mechanism. To determine the role of DeltaNp73 in NB we analyzed the
pattern of expression of this gene in vivo and evaluated the prognostic
significance of its expression. Our results indicate that DeltaNp73
expression is associated with reduced apoptosis in a NB tumor tissue.
Expression of this variant in NB patients significantly correlates with
age at diagnosis and VMA urinary excretion. Moreover it is strongly
associated with reduced survival (HR=7.93; P<0.001) and progression-free
survival (HR=5.3; P<0.001) and its role in predicting a poorer outcome
is independent from age, primary tumor site, stage and MYCN
amplification (OS: HR=5.24, P=0.012; PFS: HR=4.36, P=0.005). In
conclusion our data seem to indicate that DeltaNp73 is a crucial gene in
neuroblastoma pathogenesis.
AU - Gondim J; Ramos F Jr; Azevedo J; Carrero FP Jr; Tella OI Jr
Esthesioneuroblastoma: case report.
SO - Arq Neuropsiquiatr 2002 Jun;60(2-A):303-7
AD - Hospital Geral de Fortaleza, Fortaleza, CE, Brazil.
Esthesioneuroblatoma (ENB) is a rare tumor arising from the olfactory
epithelium of the nasal vault which frequently invades the cranial base,
cranial vault and orbit. ENB has a bimodal age distribution between 11
and 20 years and between 51 and 60 years. ENB accounts for approximately
1 to 5% of intranasal cancers and no consensus has been reached
regarding treatment of this tumor. We report on a 66 year old female
patient with a Kadish stage C tumor with frontal lobe invasion submitted
a total craniofacial resection with a combined head neck and
neurosurgeon team. The purpose of this study is to analyze the natural
history, treatment and prognosis of this tumor, based on the literature
AU - Lopez-Carballo G; Moreno L; Masia S; Perez P; Barettino D
Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by
retinoic acid is required for neural differentiation of SH-SY5Y human
neuroblastoma cells.
SO - J Biol Chem 2002 Jul 12;277(28):25297-304
AD - Instituto de Biomedicina de Valencia, Consejo Superior de
Investigaciones Cientificas, Spain.
Retinoic acid (RA) induces neural differentiation of SH-SY5Y
neuroblastoma cells. We show that the mRNA levels of the
differentiation-inhibiting basic helix-loop-helix transcription factors
ID1, ID2, and ID3 are down-regulated during RA-induced differentiation
of SH-SY5Y cells. The levels of ID proteins decreased in parallel to the
observed transcriptional repression. The expression of other basic
helix-loop-helix genes changed during RA-induced differentiation:
expression of neuroblast-specific ASCL1 (HASH-1) gene was promptly
reduced after RA treatment, whereas expression of
differentiation-promoting genes NEUROD6 (NEX-1, HATH-2) and NEUROD1 was
increased. Treatments with 12-O-tetradecanoylphorbol-13-acetate, another
inducer of neuroblastoma cell differentiation, also resulted in
coordinated down-regulation of ID gene expression, underscoring the role
of ID genes in differentiation. Down-regulation of ID gene expression by
RA involves a complex mechanism because full transcriptional repression
required newly synthesized proteins and signaling by
phosphatidylinositol 3-kinase (PI3K). RA treatment activates the
PI3K/Akt signaling pathway, resulting in increased PI3K activity in
extracts from RA-treated cells and a rapid increase in phosphorylation
of Akt in Ser-473. Inhibition of PI3K by LY294002 impaired RA-induced
differentiation, as assessed by morphological and biochemical criteria.
We propose that RA, by activating the PI3K/Akt signaling pathway, plays
an important role in the regulation of neuronal cell survival.
AU - Imaizumi M; Watanabe A; Kikuta A; Takano T; Ito E; Shimizu T; Tsuchiya
S; Iinuma K; Konno T; Ohi R; Hayashi Y; Tohoku Neuroblastoma Study Group
Improved survival of children with advanced neuroblastoma treated by
intensified therapy including myeloablative chemotherapy with stem cell
transplantation: a retrospective analysis from the Tohoku Neuroblastoma
Study Group.
SO - Tohoku J Exp Med 2001 Oct;195(2):73-83
AD - Department of Pediatric Hematology and Oncology, Tohoku University
School of Medicine, Sendai, Japan. firstname.lastname@example.com
In the hospitals of the Tohoku Neuroblastoma Study Group (TNBSG),
treatment for children with advanced neuroblastoma (NB) was intensified
in the mid-1990's with the introduction of myeloablative therapy (MT)
with stem cell transplantation (SCT) including the use of autologous
peripheral blood stem cells (PBSC) and bone marrow transplantation
(BMT). In this report, we examined whether the intensified therapy
improved the outcome of children with advanced NB (age> 12 months) who
were diagnosed between 1991 and 1997. Patients were 36 children (23 boys
and 13 girls) with an average age of 3.4 years (range; 1 to 14 years).
Six of them had stage III disease, and the other 30 had stage IV. They
were treated initially with induction chemotherapy, surgery, and
post-operative chemoradiotherapy, after which 17 of them continued
further chemotherapy and the other 19 received MT/SCT (18 with PBSCT and
1 with BMT). Progression-free survival (PFS) rate at seven years from
diagnosis was 43.5% for all patients, 66.7% for stage III patients and
38.2% for stage IV patients. The difference between stage III and IV
patients was not significant. Among the 30 patients with stage IV
disease, PFS at seven years was significantly higher in the 19 patients
who received MT/SCT (55.6%) than in the 11 patients who did not receive
it (12.5%). There was no difference in clinical and biological risk
factors between these two groups, except for the proportion of patients
with favorable response to initial therapy (36% and 80% for patients
without and with MT/SCT, respectively). Furthermore, the proportion of
patients with N-myc amplification was significantly higher in patients
with progressive disease (PD) after MT/SCT than in those in CR after
MT/SCT. The results of this retrospective study of children with
advanced NB suggest that therapy intensification involving MT/SCT might
result in lengthened survival time for patients with stage IV disease,
and that post-transplant PD remains a risk for patients with high levels
of N-myc amplification.
AU - Lastowska M; Cotterill S; Bown N; Cullinane C; Variend S; Lunec J;
Strachan T; Pearson AD; Jackson MS
Breakpoint position on 17q identifies the most aggressive neuroblastoma
SO - Genes Chromosomes Cancer 2002 Aug;34(4):428-36
AD - Institute of Human Genetics, International Centre for Life, University
of Newcastle upon Tyne, Central Parkway, Newcastle upon Tyne NE1 3BZ,
UK. firstname.lastname@example.com
Gain of chromosome arm 17q is a powerful prognostic factor in
neuroblastoma, and the distribution of 17q breakpoints suggests that the
dosage of one or more genes in 17q22-23 to 17qter is critical for tumor
progression. To identify the smallest region of 17q gain, we used eight
probes to map translocation breakpoints in 48 primary neuroblastoma
tumors. We identified at least five different breakpoints, all localized
within the proximal part of 17q (from D17Z1 to MPO). The shortest region
of gain identified by these probes extends from MPO (17q23.1) to 17qter.
Surprisingly, we found that breakpoints localized proximal to ERBB2
(17q12) were associated with significantly better patient survival than
breakpoints localized distal to ERBB2. Breakpoints localized distal to
ERBB2 identified patients with a particularly poor prognosis, higher
mitotic karyorrhectic index, and stage 4 disease. This implies that
breakpoint position on 17q is a discriminative factor within this
prognostically poor group of patients. This result also suggests that
the biological effect of 17q gain during neuroblastoma progression has a
complex basis. We propose that this involves dosage alterations of genes
localized on both sides of the 17q breakpoints, with a gene or genes
mapping between 17cen and 17q12 acting to suppress progression, and a
gene or genes mapping between 17q23.1 and 17qter acting to promote tumor
progression. Copyright 2002 Wiley-Liss, Inc.
AU - Iwasaki I; Sugiyama H; Kanazawa S; Hemmi H
Establishment of cisplatin-resistant variants of human neuroblastoma
cell lines, TGW and GOTO, and their drug cross-resistance profiles.
SO - Cancer Chemother Pharmacol 2002 Jun;49(6):438-44
AD - Department of Molecular Biology, Toho University School of Medicine,
5-21-16 Ohmori-Nishi, Ohta-Ku, Tokyo 143-8540, Japan.
PURPOSE: The emergence of multidrug resistance (MDR) in neuroblastoma is
a critical issue for chemotherapy. In order to study low-level MDR, we
developed variants derived from two neuroblastoma cell lines, TGW and
GOTO, by exposure to low doses of cisplatin (CDDP). The cross-resistance
to other cytotoxic agents and expression of MDR-related proteins in the
variants and their clones were examined. MATERIALS AND METHODS: Cells
were exposed to 3 or 10 micro M CDDP and three variants were obtained
from each cell line, TGW and GOTO. Clones TR1 and TR2, derived from the
TGW variants, were also established. Cytotoxicity was determined using a
dye-staining method. Expression of MDR-related proteins was detected by
immunoblotting. RESULTS: Resistant variants exhibited 1.1- to 2.5-fold
increased resistance to CDDP, N-methyl- N'-nitro- N-nitrosoguanidine
(MNNG), doxorubicin and vincristine. The cytotoxicity of these agents
varied between clones of resistant variants. The microsatellite profiles
of the TR1 clones differed, indicating that the TR1 variant comprised a
heterogeneous cell population. The cytotoxicities of cytosine beta-
D-arabinofuranoside (Ara-C) and chlorambucil in these variants and
clones were similar to those in the parent cells. No significant changes
in the cellular levels of MDR1, MRP, hMLH1 and hMSH2 were detected in
the TGW variants. Cyclosporin A increased the sensitivity of both
parental cell lines and the variants to doxorubicin and vincristine, but
not to CDDP or MNNG. CONCLUSIONS: Ara-C and chlorambucil may be useful
for the treatment of neuroblastoma exhibiting an MDR phenotype. These
CDDP-resistant variants and clones may be useful for studying the
mechanisms of low-level drug resistance in neuroblastoma.
AU - Seiler AE; Ross BN; Rubin R
Inhibition of insulin-like growth factor-1 receptor and IRS-2 signaling
by ethanol in SH-SY5Y neuroblastoma cells.
SO - J Neurochem 2001 Jan;76(2):573-81
AD - Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson
University, Philadelphia 19107, USA.
The effect of ethanol on insulin-like growth factor-1 (IGF-I)-mediated
signal transduction and functional activation in neuronal cells was
examined. In human SH-SY5Y neuroblastoma cells, ethanol inhibited
tyrosine autophosphorylation of the IGF-I receptor. This corresponded to
the inhibition of IGF-I-induced phosphorylation of p42/p44
mitogen-activated/extracellular signal-regulated protein kinase (MAPK)
by ethanol. Insulin-related substrate-2 (IRS-2) and focal adhesion
kinase phosphorylation were reduced in the presence of ethanol, which
corresponded to the prevention of lamellipodia formation (30 min). By
contrast, ethanol had no effect on Shc phosphorylation when measured up
to 1 h, and did not affect the association of Grb-2 with Shc. Neurite
formation at 24 h was similarly unaffected by ethanol. The data indicate
that the IGF-I receptor is a target for ethanol in SH-SY5Y cells
However, there is diversity in the sensitivity of signaling elements
within the IGF-I receptor tyrosine kinase signaling cascades to ethanol,
which can be related to the inhibition of specific functional events in
neuronal activation.
AU - Bagatell R; Morgan E; Cosentino C; Whitesell L
Two cases of pediatric neuroblastoma with tumor thrombus in the inferior
vena cava.
SO - J Pediatr Hematol Oncol 2002 Jun-Jul;24(5):397-400
AD - Department of Pediatrics and Steele Memorial Children's Research Center,
Tucson, Arizona, USA. firstname.lastname@example.com
The authors describe two children with abdominal neuroblastoma with
radiographic evidence of tumor extension into the inferior vena cava.
Imaging studies were suggestive of Wilms tumor, but histologic analysis
revealed neuroblastoma. In one patient a pulmonary embolus developed
after initiation of cytotoxic therapy; the second patient was
prophylactically anticoagulated and had no embolic event.
AU - Odone-Filho V; Cristofani LM; Bonassa EA; Braga PE; Eluf-Neto J
In vitro fertilization and childhood cancer.
SO - J Pediatr Hematol Oncol 2002 Jun-Jul;24(5):421-2
AU - Tanaka N; Yoshida K; Imada A; Kojima H; Nakamura N; Yoshida Y; Hasegawa
N; Abe S
[A case of ganglioneuroblastoma occurring in the superior mediastinum in
an adult]
SO - Nihon Kokyuki Gakkai Zasshi 2002 May;40(5):378-82
AD - Department of Respiratory Medicine, Kushiro City General Hospital,
Shunkodai 1-12, Kushiro, Japan.
We report a case of ganglioneuroblastoma occurring in the superior
mediastinum in adult. A 63-year-old man was admitted to our hospital for
detailed investigation of an abnormal shadow on his chest radiograph.
Chest radiography and CT imaging showed a left superior mediastinal
tumor. Histopathologically, the tumor was identified as a
ganglioneuroblastoma. Although ganglioneuroblastomas occur predominantly
in children, 3 cases have been reported in adults in Japan.
Incidentally, this is the first reported case of ganglioneuroblastoma
occurring in the superior mediastinum in Japan.
AU - Suita S
Stephen L. Gans overseas lecture. Mass screening for neuroblastoma in
Japan: lessons learned and future directions.
SO - J Pediatr Surg 2002 Jul;37(7):949-54
AD - Department of Pediatric Surgery, Reproductive and Developmental
Medicine, Graduate School of Medical Sciences, Kyushu University,
Fukuoka, Japan.
BACKGROUND/PURPOSE: Since 1985, a nationwide mass screening program (MS)
for neuroblastoma has been conducted for 6-month-old infants throughout
Japan, resulting in the detection of more than 1,900 cases of
neuroblastoma. The outcome of these patients has been excellent: more
than 97% of them are alive. Yet, several reports suggest that the number
of advanced-stage neuroblastoma patients over 1 year of age has not
changed substantially. The current report focuses on the 15-year
experience with MS of the Kyushu Pediatric Oncology Study Group.
METHODS: The clinical and biological features of neuroblastoms detected
(n = 320) and not detected by MS (n = 245) were compared. Regional and
national statistics for neuroblastoma before and after 1985 were
analyzed using standard epidemiologic measures for the occurrence of
disease. RESULTS: The majority of the MS-positive cases were
biologically favorable and had an excellent outcome. In contrast, the
majority of non-MS patients in whom neuroblastoma later developed had
advanced-stage, unfavorable-prognosis tumors. The overall mortality rate
of neuroblastoma in the Kyushu area was not improved by MS. CONCLUSIONS:
The optimal time for screening is the point at which neuroblastomas
regressing spontaneously can no longer be detected, but more aggressive
disease can be found. A birth cohort study could determine the optimal
timing for a second screening. Identification of other new prognostic
factors may be required. Copyright 2002, Elsevier Science (USA). All
rights reserved.
AU - Riazimand SH; Brieger J; Jacob R; Welkoborsky HJ; Mann WJ
Analysis of cytogenetic aberrations in esthesioneuroblastomas by
comparative genomic hybridization.
SO - Cancer Genet Cytogenet 2002 Jul 1;136(1):53-7
AD - Department of Otorhinolaryngology, University Hospital School of
Medicine, Mainz, Germany.
Esthesioneuroblastoma (ENB) are rare tumors originating from the
olfactory epithelium of the superior nasal cavity. This lesion is
morphologically closely related to Ewing sarcoma and other peripheral
primitive neuroectodermal tumors (pPNET). The affiliation of ENB to the
pPNET family is still under discussion. Only very limited and
contradictory cytogenetic data are available on ENB and only one patient
has been analyzed by comparative genomic hybridization (CGH), so far. In
the present study, genomic imbalances of three ENB were analyzed by CGH
to evaluate (1) a recurrent pattern of imbalances, and (2) its relation
to the pPNET family. The CGH analysis of three ENB revealed multiple
recurrent aberrations including DNA overrepresentations of chromosomal
material of the entire chromosome 19, partial gains of the long arms of
chromosomes 8, 15, and 22, and deletions of the entire long arm of
chromosome 4. Beside these common aberrations, several single gains and
losses occurred, that is, gains on 6p, 10q, 1p, 9q, and 13q. We
confirmed the former observation of amplified genetic material on
chromosome 8 and found several new, currently not described recurrent
genetic aberrations distinct from those described for pPNET. Our
findings give evidence that ENB is not part of the pPNET family. We
suggest that the combined gain of genetic material on 15q, 22q, and
chromosome 8 might be indicative for ENB. To verify our findings and to
define prognosis-related aberrations, a larger number of cases needs to
be studied.
AU - Richardson UI; Wurtman RJ
Characterization of [3H]MK-801 binding in LA-N-2 neuroblastoma cells.
SO - Ann N Y Acad Sci 1992 May 11;648():328-9
AD - Laboratory of Neuroendocrine Regulation, Massachusetts Institute of
Technology, Cambridge 02139.
AU - Ichikawa H; Sugano H; Tanada S; Sawada T; Nakayama K; Yorimitsu S;
Takahashi I; Iwata J
[Diabetes mellitus with mixed neuroendocrine-neural tumor]
SO - Nippon Naika Gakkai Zasshi 2002 Apr 10;91(4):1309-12
AD - Department of Internal Medicine, Kochi Municipal Central Hospital,
AU - Holzer R; Franklin RC
Congenital heart disease and neuroblastoma: just coincidence?
SO - Arch Dis Child 2002 Jul;87(1):61-4
AD - Paediatric Unit, Harefield Hospital, Royal Brompton and Harefield NHS
Trust, Harefield, UK.
The clinical history of a neonate with simple transposition of the great
arteries in whom a metastatic neuroblastoma was diagnosed incidentally
at autopsy is described, and the literature containing all 66 previously
reported cases of neuroblastoma associated with congenital cardiac
malformations is reviewed. One third of the described cases were
classified as in situ neuroblastoma; neural crest derived cardiac
lesions were present in 31%. Several possible aetiological mechanisms
are discussed, and we conclude that the association of neuroblastoma
with congenital cardiac malformations is multifactorial in origin. The
described case represents the first reported example in which
catecholamine release may have contributed to the fatal outcome of
definitive congenital cardiac surgery.
AU - Emran MA; Rebbaa A; Mirkin BL
Doxorubicin resistant neuroblastoma cells secrete factors that activate
AKT and attenuate cytotoxicity in drug-sensitive cells.
SO - Cancer Lett 2002 Aug 8;182(1):53-9
AD - Department of Surgery, Illinois Masonic Medical Center, Children's
Memorial Institute for Education and Research (CMIER), Cancer Biology
and Chemotherapy Program, Northwestern University Medical School,
Chicago, IL 60614, USA.
The present study aims to verify the hypothesis that tumor cells with
acquired resistance to chemotherapy may secrete survival factors and
thus, participate in the protection of drug-sensitive cells against drug
toxicity. A human neuroblastoma cell line, SK-N-SH, and its doxorubicin
resistant derivative, RDOX6, have been used. Conditioned medium from
RDOX6 cells attenuated the cytotoxic response of SK-N-SH cells to
doxorubicin. This protective effect was associated with activation of
the Akt survival pathway and inhibition of caspase-3. These data
indicate that secretion, by drug-resistant cells, of factors that
activate anti-apoptotic pathways in drug-sensitive cells, may constitute
a novel mechanism of drug resistance.
AU - Beltinger C; Fulda S; Walczak H; Debatin KM
TRAIL enhances thymidine kinase/ganciclovir gene therapy of
neuroblastoma cells.
SO - Cancer Gene Ther 2002 Apr;9(4):372-81
AD - University Children's Hospital, Ulm 89075, Germany.
The clinical benefit of suicide gene therapy of tumors has been
marginal, mostly due to the low gene transfer efficiency in vivo. The
death-inducing ligand, TRAIL, effectively kills many tumor cell types,
while sparing most normal tissues. We hypothesized that TRAIL may
enhance HSV thymidine kinase/ganciclovir (TK/GCV) gene therapy of tumor
cells by augmenting both target and bystander cell kill. Human SH-EP
neuroblastoma cells expressing TK as well as bystander cells were
effectively killed by apoptosis, and their clonogenicity was ablated
following GCV. Human TRAIL enhanced TK/GCV-induced cell death and
decreased clonogenicity of TK-expressing cells and also of bystander
cells. Cooperation between TRAIL and TK/GCV depended both on caspase
activation and on mitochondrial apoptogenic function because both the
broad-spectrum caspase inhibitor zVAD.fmk and overexpression of Bcl-2
decreased enhancement of cell kill by TRAIL. Facilitation of TRAIL
signalling by up-regulation of TRAIL receptors did not contribute to
enhancement because cell surface expression of the agonistic TRAIL
receptors 1 and 2 was not increased by TK/GCV. In conclusion, the
concerted activation of caspases and the mitochondrial amplification of
caspase activation by TK/GCV may explain the cooperative effect of
TK/GCV and TRAIL on the kill of neuroblastoma cells. Because combined
treatment also augmented the bystander cell kill, the addition of TRAIL
may increase the efficacy of TK/GCV gene therapy of neuroblastoma.
AU - Mora J; Gerald WL; Qin J; Cheung NK
Evolving significance of prognostic markers associated with treatment
improvement in patients with stage 4 neuroblastoma.
SO - Cancer 2002 May 15;94(10):2756-65
AD - Department of Pathology, Memorial Sloan-Kettering Cancer Center, New
York, New York, USA. firstname.lastname@example.com
BACKGROUND: With recent improvements in the treatment and outcome of
patients with neuroblastoma (NB), the authors reassessed the prognostic
importance of clinical and biologic markers in patients with Stage 4 NB
who were treated at the Memorial Sloan-Kettering Cancer Center (MSKCC).
METHODS: The authors analyzed 84 patients with Stage 4 NB who were
treated on the N5, N6, or N7 protocols at MSKCC from 1987 to 1999. The
impact on survival of clinical factors (age, serum ferritin, and lactate
dehydrogenase [LDH] levels), histopathology (International Neuroblastoma
Pathology Classification [INPC]), and tumor biologic markers (MYCN;
ploidy; loss of heterozygosity [LOH] at 1p36, 1p22, 11q23, 14q12-q32,
9p21, and 19q13; and gain at 17q) were analyzed in univariate and
multivariate models. RESULTS: Forty-six of 84 patients were alive at the
time of this report (55%), with a median follow-up of 41 months from the
time of diagnosis. In the univariate analysis, there was no prognostic
impact on survival by age, serum ferritin and LDH levels, MYCN, 1p36
LOH, 14q32 LOH, or 17q gain. LOH at 11q23 was associated significantly
with superior progression free survival (P = 0.04) and survival (P =
0.04) in the univariate analysis. In the multivariate analysis, it was
found that 11q23 status was the most significant variable associated
with overall survival (hazard ratio, 0.50; 95% confidence interval,
0.26-0.99). LOH at 11q23 and LOH at 1p22 were highly correlated (P =
0.02). It was found that 11q23 status and INPC score were the most
significant variables associated with progression free survival.
CONCLUSIONS: Because patient survival improves with more effective
therapy, traditional prognostic markers, such as age, MYCN
amplification, and elevated serum LDH levels, have become less important
for patients with Stage 4 NB. In the current study, less common
chromosomal abnormalities (LOH at 1p22 and 11q23) appeared to assume new
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.


text:
A product tip from the "Ground Joint Components" range
All BOLA sleeves are sealing without any grease and the product will not be contaminated by any greasy residues. They are made for creating gastight, liquid-tight and vacuum tight ground joint connections.
Sealing rings on the outside of the sleeves and a low friction coefficient prevent sticking of the ground joints. This reduces the danger of breaking and injury.
The sleeves have an excellent chemical resistance and can be used at working temperatures between -200°C and + 250°C.
Their solid construction (partly with gripping ring) makes them suitable for continued use.
All common joint clamps can still be used.
The sleeves are available for European and American ground joint sizes.


text:
Favstar gets even better if you sign in.
The first time I saw a boob, I congratulated the girl on 'growing such a magnificent blob'.
I was weird.
@1dneews Zayn laughing http://25.media.tumblr.com/5c435b4ceffc905f7b1e036347ca2009/tumblr_mmzfvgNtSa1rvb3qjo2_250.gif … the best thing ever!
Always remember that you are absolutely unique. Just like everyone else. MARGARET MEAD
Just watched Kanye West give the most terrifying PowerPoint presentation I've ever seen.
First time I saw @superelmo make akbay to @myjaps aww :) Juli3lmo RedMask Medley
"So I Married an Axe Murderer" was the last movie before everyone whitened their teeth.
Excited for the @billboard Music Awards tomorrow! My first time going. I'm introducing a certain boy who's performing *cough* Justin Bieber!
If a woman asks you to guess her age, always subtract 10 years from your estimate. IMPORTANT: Do NOT do this if she's in her early twenties.


text:
Reggie Brown to Bucs
24-hour breaking news, sports, weather, entertainment, and more with coverage from The Philadelphia Inquirer and Daily News.
Reggie Brown to Bucs
Les Bowen
There is no NFL salary cap, and Reggie Brown is no longer being held hostage in Philadelphia by the cap penalty the Eagles would pay for jettisoning him. The team just announced that the once-promising wideout is going to Tampa Bay for an undisclosed 2011 pick, which the Tampa Tribune says is a sixth-rounder.
Brown, a second-round draft choice in 2005, set a team rookie receiving record that year, but the past two years have seen a steady, puzzling decline that resulted in him barely being used at all in 2009. He went from 61 catches in 2007 to 9 last season.
Comments (41)
- When the poll first came up asking if we got enough for him the article still was saying it was an undisclosed draft choice. Wha'ts hilarious is that over 70% of the people were voting yes even though they had no idea what the pick was.
- fly4philly
- goomba102
- bigjay215
- Move along, nothing to see here. Eagles got low-value pick for low-value player. Next.
- Let's not get too bend out of shape about (another) wasted second round pick...didn't we fleece this pick from Miami for AJ Feely who ended up back with us the next season or two anyway? But to the fact that it was a bad draft choice...cannot argue with that. Another in along line of Reid wasted picks.
- He was a disappointment.And he dropped too many balls.
- wingnut12
- djax10
- bow
- dasher
- slade1955
- notch44
- Dr. Michael
- Comment removed.
- RoastedBird
- Seed
- I remember not long ago the organization was telling us not to worry about losing T.O. because they had drafted Reggie Brown. Maybe the sixth round wide receiver we draft with the pick we got from Tampa Bay will be in Todd Pinkston's league. Nothing to see here of course, because we all know the gold standard is making all the right moves.
- kjuggs77
- Eagles: "We know you need a wideout, and we got a, uh, former 2nd rounder who set a rookie receiving record and mayyybe available for the right price..." Tampa: "Wow!! DeSe--" Eagles: "Nononononoo. No. Nooooo. Sorry, we meant Reggie Br--" Tampa: "We'll give you a 7th." Eagles: "Sixth. And a sleeve of golfballs." Tampa: "Those new Titleists?" Eagles: "(long pause) Whatever"
- realtruth
- disgruntled fan
- Adam Smythe
- dennismithusa
- xatsmann
- hallux
- oirerflaksdjflijfifasdf
- Ya beat me to the punch ryno…pretty sad if this goes down as the biggest addition (by subtraction) move the Eagles make this offseason. Wonder if all this cap penalty stuff ultimately led to Brandon Gibson being traded instead of just releasing Brown. (I do wish Reggie luck though. Maybe a fresh start will help re-start his career.)
- retzlaff
- absinthetic8
- tampaPhillyfan
- Phront_Runner
- ant8817
- brickhead
- soulman386
- soulman386
- Comment removed.
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Rs. 165/-
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Rs. 1499/-
General | |
Artist | One Direction |
Title | Up All Night |
Category | Music |
Format | Audio CD |
Language | English |
Year | 2012 |
Label | Sony Music |
Track Listing | 1. What Makes You Beautiful 2. Gotta Be You 3. One Thing 4. More Than This 5. Up All Night 6. I Wish 7. Tell Me A Lie 8. Taken 9. I Want 10. Everything About You 11. Same Mistakes 12. Save You Tonight 13. Stole My Heart |
Number Of Discs | 1 |
Genre | Pop |
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Hair care
6 Best Wen Products -- and the 2 Worst
Wondering if Wen products really work or if it's all hype? See what the buzz is about
The Best: No. 6: Wen Tea Tree Cleansing Conditioner, $28
TotalBeauty.com average reader rating: 7.3*Why it's great: This "amazing" product is perfect "if you have scalp issues," because it "takes away dandruff, cleanses and conditions hair, strengthens hair [and] moisturizes" all in one. "After several uses I felt for the first time in my life that my problem had been cured," raves one reader. "I can tell a noticeable difference in my hair's ability to maintain moisture." Another reader says it keeps her red hair beautiful and vibrant, and "the longer you use [it], the better your hair will look and you'll be amazed at the shine!" Readers love the "clean, tingly feeling" it leaves on the scalp, and the way it leaves them with "salon hair everyday!"
Agree? Disagree? Write your review here.
*At time of publication
SEE NEXT PAGE: No. 5: Wen Sweet Almond Mint Cleansing Conditioner, $28
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Missouri area has nation's strongest military presence
Fort Leonard Wood is a massive Army installation in the Missouri Ozarks. It's also the name of a micropolitan area encompassing the base and surrounding portions of Pulaski County, Mo.
There were 28,810 persons in micropolitan Fort Leonard Wood's labor force as of 2010, according to the latest figures from the U.S. Census Bureau. The area's biggest employer -- no surprise -- is the armed forces, with 12,136 workers.
The resulting ratio indicates that Fort Leonard Wood has the nation's strongest concentration of active-duty military personnel: 4,212 armed forces members among every 10,000 workers.
Seventeen other metropolitan and micropolitan areas have ratios above 1,000, which means that more than 10 percent of all local workers are in the military. The runners-up behind Fort Leonard Wood are Jacksonville, N.C., the home of Camp Lejeune (Marines); Fort Polk South, La., the site of Fort Polk (Army); and Mountain Home, Idaho, the location of Mountain Home Air Force Base.
The database below has breakdowns for all 942 metros and micros, counting the number of armed forces members within each area's workforce. Use the tab to isolate a single state, or simply click Search to see everything at once.
If the list is winnowed to the 50 biggest metropolitan areas, Virginia Beach-Norfolk has the strongest military presence, with 882 armed forces members per 10,000 workers. Virginia Beach is home to Naval Air Station Oceana, while Naval Station Norfolk is located in the adjacent city.
Rounding out the list of the five major markets with the strongest concentrations of military personnel and the dominant branch are San Diego (Navy), San Antonio (Army and Air Force), Jacksonville, Fla. (Navy), and Washington (all branches).
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On Numbers Around the Country
- Charlotte down, Raleigh up on economic index Charlotte
- Denver ranks 7th best among 102 cities in Business Journals economic index Denver, Broadway & 17th
- Five cities where it pays to be a home seller Washington, D.C.
- Nielsen expands definition of TV viewing Los Angeles
- San Antonio is one of the best cities in America for small businesses San Antonio
- Business Development Partner Corporate Management Group, LLC | Local Opportunity
- High Net Worth/Premium Representative Fidelity Investments | Greenwood Village, CO
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But some companies in this niche are responding to a long list of setbacks with the goal of making architect-designed, factory-built green homes more accessible to the masses -- and, in return, they're feeling the love from Dwell on Design.
Los Angeles' premier modernism expo curated by Dwell magazine celebrates their work Sunday with the first-ever Prefab Plus Home Tour, a ticketed self-guided driving tour of five homes that reflect varying degrees of factory completion, from kits assembled on-site to fully completed modules delivered by truck.
Another five homes will be installed on the floor of the Los Angeles Convention Center in the pop-up Dwell Outdoor village during the run of the three-day show, which opens Friday.
"There seems to be perennial interest in prefab," says Michael Sylvester, managing director of Dwell on Design and a writer for the namesake publication that puts out a yearly prefab issue.
This isn't housing on a chassis.
Prefab modular homes are well-designed pieces of modern architecture that come with all the latest green bells and whistles such as solar-powered electricity and hot water. They're also sustainably built, which is an attractive idea to a growing number of people.
Prefab wasn't the sort of thing Eric Chu had in mind when he set out to replace his small 1936 bungalow in West Los Angeles with new construction. Then he stumbled on a panel discussion on the subject and like many design lovers, the 36-year-old software entrepreneur was sold.
There was just one snag.
"My lot is pretty narrow and no company's prefab design would fit it," Chu says.
After several misses he approached L.A.-based Whitney Sander Architects Hybrid Houses, whose principal was one of three prefab architects featured on the panel that had won him over.
Sander showed Chu it was possible to fit the lot with a part prefab, fully customizable structure.
For Chu, the only trouble was settling on a design.
He ended up going with a pair of steel-framed townhouses that face each other over a drivable courtyard.
Opposing glass walls and sliders glazed in graphics create privacy by obscuring the view from the outside in, but not the other way around.
On the rooftop of each three-story structure his tenants have a deck.
The air-conditioning unit, solar water heating system and space for electricity-generating solar panels still to come are also housed on the roof.
"We used bamboo floor, recycled
Dubbed "Green House," the twin townhouses are a stop on Sunday's home tour alongside other progressive designs, including Taalman Koch Architecture's Backyard Plug-In - a 750-square-foot addition to an existing 1940s house in Santa Monica with radiant heat flooring.
"Even with all those advantages, if it costs more it's a hard sell," says Jared Levy, co-founder of Corona-based Connect:Homes who will launch his company at Dwell Outdoor with a 640-square-foot one-bedroom, one-bath modular home that starts at $140 a square foot out of the factory, which includes all of the fixtures, appliances and finishes.
All of its home prices are quoted at the company's website, www.connect-homes.com.
This kind of price is significantly more affordable than past iterations of prefab and could spell change in the industry. How is it possible?
"We're able to move almost all of the construction to the factory, which is what high-end modular companies say they can do but ultimately a lot of the work gets left to the site to be completed and that's where you can't predict how much things will eventually cost," says Gordon Stott, who partnered with Levy to streamline the process after working together at prefab pioneer Marmol Radziner Prefab.
The duo also worked out a way to keep delivery costs from spiraling out of control by making smaller modules that can ship in intermodal containers anywhere in the world from a single factory for $500 to $4,000.
"You give us a call, we send you a house," Levy says. "It becomes like any other product in the world where delivery doesn't break the bank to move things around the world," Levy says.
"We've tried to make this the first global housing company," Stott says.
Dwell on Design Prefab Plus Home Tour
What: The latest and greatest prefab structures L.A. has to offer.When: 10 a.m. to 4 p.m. Sunday.
Tickets: $85.
Information: To purchase tickets for the prefab home tour or to register for Dwell on Design, visit http://dod.dwell.com.
Follow Sandra Barrera on Twitter at http://twitter.com/sandrabarrera18


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30 Days for $30 Intro Special! 30 days of unlimited classes for only $30 for introductory students!! You can upgrade from the 2 Week Special! The Early Bird Special: 6 at 6! From now on the 6:00am class (Monday thru Friday) at Auburn is ONLY $6.00 per class!!
Welcome Groupon Students! Please click here to learn how to register for classes. Thanks! Need Your Receipt? For receipts please e-mail Sam at firstname.lastname@example.com. You can either pick up your receipts at the front desk or we can mail it to you. Private Lessons We are now offering private lessons for individuals and groups! Check out the pricing page for details!
Bikram C, Sam G, and Diane D
Bikram Yoga Auburn 567 Southbridge Street Auburn, MA 01501 (508) 832-YOGA (9642) email@example.com
Memorial day weekend (May 25-27 Sat, Sun, and Mon) we will have 8am and 10am classes only. Have a fun and be safe!
Our Summertime schedule begins Tuesday 5/28. There will be no 3:30pm classes in Westboro on Mon, Tues, or Wed. We will still have a Friday at 3:30pm class. There will be no noon classes at our Auburn studio. All other classes will remain the same.
Please be advised that a person may only use one 5 class Groupon. If you get a second 5 class Groupon it is not valid for you to use for classes or as a credit towards classes.
We have an updated registration form that every new and current student will have to read and sign. For your convenience you can print out a registration form by clicking here.
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10:00 am
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7:30 pm
Click here for a printable schedule.
We will start locking the front door at the Auburn studio when class begins. Please arrive early. You will be able to leave the building, but the front door will lock behind you.
For your convenience, you have the option to purchase classes at the studio, or you can click here to pay online. Powered by MINDBODY.
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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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Pros: Installed this into an old Asus Maximus II Formula, connected 2 Red WD 3T drives, Win 7, installed drivers from the cards website and had RAID 0 Mirrored up and running in about 5 mins. Cons: None, does what they state it will. Other Thoughts: PCI x1 is slow, that in mind a good value. 1 out of 1 people found this review helpful. Did you? |
Koutech IO-PESA230Pros: Cheap price for what options/performance is advertised Cons: with website driver installed after card was inserted, card performed only as fast as a sata 3gbs and the thru put was considerably lower than my on board sata6gbs 2 out of 2 people found this review helpful. Did you? |
Koutech IO-PESA230 PCI ExpressPros: cheap if it did what it was supposed to Cons: speed is half of what mb sata6 is. driver loaded properly from website and retried and nothing, no improvement. Did you find this review helpful? |
avoid this card at all costs!Pros: None. Cons: Card literally went up in smoke on its inital boot. I was able to power down the machine almost immediaelty, but am not yet sure if it melted the motherboard's PCIe slot. Other Thoughts: I've built dozen's of PCs before and have never had something like this happen. Pretty scary. Did you find this review helpful? |
good card, a little priceyPros: Works fine so far. Easy to install. Cons: Not necessarily a con, but card is very short and small. For large cases, use 24" cables. Other Thoughts: I read all the reviews before purchase, so I'm not using this card for boot drives but extra 3tb storage drives. I wonder if most of the negative reviews are from users with older mobos that simply don't support SATA III? A lot of it seems like user error. Did you find this review helpful? |
We will see how long it livesPros: Once physically installed and connected to Western Digital Red WD20EFRX 2TB drive, Windows 7 recognized it without further fuss... for a while. I initially went to the KOUTECH website and tried to install the downloaded drivers from there. If it doesn't take the first time try again. Cons: Windows System wasn't happy with the driver it had, and thats where the fun starts. AVOID THE CD. The MARVELL utility that is installed from the CD has a bad security certificate, and if you choose to take a "Spin the wheel and see where it stops" attitude (like I did) you get System Crash - Blue Screen of Death. Other Thoughts: This card got me where I wanted to be with a bit more mucking around than I like (The printed "Instructions" leave much to be desired) but cherry picking info out of the directions, and wrassling the driver from the website, you get there. Maybe I am spoiled, this is the first adapter card that wasn't an Adaptec I have bought. 2 out of 3 people found this review helpful. Did you? |
SECOND REVIEWPros: Works fine. Cons: Wasn't easy. Other Thoughts: Bought 12/2011. Gave a 1 Egg review in 03/2012 because all sata hard drives had to be disconnected (msata for system drive) on any restart for the IO-PESA230 to work and their support was useless. Started working with a win7 update. Works fine since then, ordering another today. 1 out of 1 people found this review helpful. Did you? |
Improved Data ThroughputPros: Faster Data throughput with my new 1TB drives. I estimate about 70% faster than using SATA II. Cons: Haven't discovered any yet 1 out of 1 people found this review helpful. Did you? |
Give a larbage; this is garbage.Pros: Adds two devices... if you're lucky. Cons: Slows down OS boot from about 33 seconds up to 5 minutes. This is not a hyperbole, I am quite literal. Other Thoughts: I am not booting OS from the card. 1 out of 5 people found this review helpful. Did you? |
Pretty much works, MSI P6N PlatinumPros: Small, can now get AHCI mode for SSD. Cons: No compatibility lists. On my MOBO, freezes keyboard function prior to boot menu. Once installed, could not navigate in BIOS. Other Thoughts: I was experiencing the startup loops like some of the previous reviewers. This could have been because my mobo did not have AHCI mode, and the SSD was originally formatted as IDE (without TRIM support). So, I did the bootup with the Win7 install DVD, and as it was loading, stuck the card back into the mobo. Then, the SSD drive (ADATA 120 Gig Sata 3) was recognized, and the install went without a hitch. As I mentioned before, since this card froze my keyboard functions, I could not access the boot manager, and had to reconfigure things through Easy BCD, and iReboot as a workaround, on the SSD drive. The SSD is not at SATA 3 speeds, but probably due to the PCI-e bandwith on my aged mobo. The BIOS reading for the card reads 2.5 gbps/sec. Compared to the Spinpoint drives, however, it's like night and day...15-20 sec startup compared to minutes, and Protools feels much snappier. Good luck to anyone with a similar setup, and is thinking about geeking it out for a night. 2 out of 3 people found this review helpful. Did you? |
"Works on my Gigabyte GA-MA785G-UD3H running WHS with Western Digital caviar green 2TB drives.— 11bravo 7/5/2010
Installed using included ..."
"Works as advertised, fast, compatible with Linux. Easy to install. Remember... if you don't have enough 1x slots, you ..."— 10/3/2010


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Hello everyone... Welcome to I_want's Page!. SURPRISE! A new index page! YES... you are at the right page! *LOL* This page may take a short bit to load but be patient, it is worth it. (All my other pages load much faster) On this site you'll find the "nicer" type things on the internet. Such as wonderful postcards, my webring, beautiful ICQ sendable poetry, my ICQ sendables, awards, special little things for you and/or your loved ones, great links, etc. This page will be a "softer, gentler, kind of place to go". Simply click on a link and it will bring the page you want up in a new browser for you! It also include a links to my other sites (at the bottom of each page). Please check the directories below to go to what interests you.
Thank you, and I hope you enjoyed your time here. And if you have a homepage, take the time to check out the awards that I give away, be sure you meet the criteria, and then apply for one! I love going to new pages and giving awards!
The Nicer Things In Life Some Fun Things To Do
This was a wonderful One Year Anniversary Gift from my good friend Laura. This site turned 1 this month :-) Laura also made me a new award for this site and it can be seen at "Awards won page 7"
Last date updated December 7th, 2004 I have used some backgrounds and gifs here on my pages that have been found through hours of searchs on the internet. Too many to remember where they all came from. Although I used only ones that came from public domain and with permission to use them freely it seems nowadays some of these 'Public Domain' places are not so public. So, if you find one of your backgrounds or gifs here please let me know and I will give you credit and a link back to your page. Thank you. |


text: Derrick Smith, Middle Tennessee Regional Manager for Tennessee Department of Tourist Development, spoke at the February 26, 2013 Chamber of Commerce meeting. He shared information for the topic "Tennessee Tourism is Big Business." He shared information about the impact that tourism has on Macon County. Macon County is rich with history. Come by the Welcome Center and get some information about attractions in the area.


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In the December issue, David Young has great fun flying this SSDR – a lightweight solo machine without CAA Section S approval and the associated costs – but the fun is cut short with an emergency landing. This does little to change David's opinion of the steely single-seater, which he can't wait to fly again! Here are some extra photos from the day
Friday 24 May 2013 15:29 UTC |
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Faculty Bios
Olya Zaporozhets
(757) 352-4700
Ph.D. Counselor Education and Supervision, The University of Toledo
M.A. Counseling, Cincinnati Christian University
M.A. Ministry, Cincinnati Christian University
Specialist, Psychology & English, Melitopol State Pedagogical University, Ukraine
- International Counseling Education
- Chemical Dependency Counseling
- Ethical Decision Making
- Measure Development
- Statistics
- Licensed Professional Clinical Counselor (Independent Ohio License: E.0800341)
- Licensed Chemical Dependency Counselor III (Ohio License #111029)
- Certified Health Officer in Wood County, Ohio.
I like learning and hope that I will never stop being a student of God. As the Apostle Paul said, "I am rejoicing that God will continue his work in me to completion until the day of Christ Jesus" (Phil 1:6). I enjoy teaching because I like to facilitate the process of learning, observe students come from the point of confusion to mastery of new skills and knowledge that help them bring healing and faith in the lives of other people.
I was privileged to train ministers in counseling skills in Europe and Asia. It never ceased to surprise me how much my diligent students were able to learn during just one week of training and bring back to their communities. These teaching experiences convinced me to become a counselor educator.
During my clinical practice in Ohio I provided drug and alcohol treatment, as well as facilitated sexual offender groups, and conducted crises work. During my internship at a partial hospitalization program I worked with children, adolescents, and their families in the environment of daily crises. I never knew that I would absolutely love working with children until I tried.
My life is always very intense and I like it that way. I like volleyball and playing the guitar. I also love to travel, and I love to come back home.


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Does your business target the Millennial buyer? If so, you may find this recent infographic, "Getting inside the Millennial Mind", from Scarborough Research helpful.
Three items caught my eye.
First, Millennials are very into technology and shopping online. What does this mean for your business? You need to be where they are. Can you afford a small Facebook ad campaign or a social media based contest? If you have a slightly larger budget you will definitely want to include search campaigns and possibly text campaigns in your marketing program.
Second, Millennials like products with a green focus. Does your business have a sustainable practice that you can promote to this audience? Are you a local business? Find ways to take credit for business practices you are already incorporating into your communications with this buyer group. Of course, make sure that you are promoting a true practice and that you cannot be accused of "Green washing"!
Third, giving back is key! "46% of Millennials agree that they're more like to buy a brand that they know supports a charity". Find a local charity that aligns with your business goals and vision and figure out ways to support them. You could partner with them for events, assign a specific day or month to raise awareness and donate a percentage of revenue to them.
The Millennial buyer currently makes up 20% of the population and courting them early can help ensure that they become longtime, loyal customers for you and your business.
These are just some of my thoughts on how to engage this buyer group. If your business relies heavily on Millennials, what strategies have you found helpful in attracting and keeping this buyer group?


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Originally published on Thu November 8, 2012 8:46 am
And a strike by workers in Milwaukee is pitting a group of Mexican immigrants against their employer: a family-owned business that itself was founded by immigrants. As WBEZ's Niala Boodhoo reports, the dispute - involving workers and their legal status - reflects struggles of other immigrants in the workplace.
NIALA BOODHOO, BYLINE: You could call Palermo's Pizza the quintessential American success story. The company was started by Italian immigrant Gaspare Fallucca from a small bakery and restaurant on Milwaukee's East Side.
Originally published on Thu November 8, 2012 3:31 pm
And during the presidential campaign, Greece and its crushing debt often came up as a cautionary tale, as in don't let America become another Greece.
That country has now approved yet another round of deep budget cuts to avoid bankruptcy, which in turn prompted another round of protests, as Joanna Kakissis reports.
This is MORNING EDITION from NPR News. I'm Renee Montagne.
And I'm Steve Inskeep. Good morning.
House Speaker John Boehner says he's ready to work with President Obama on a looming fiscal problem. Republicans kept control of the House on Tuesday, though they also lost seats. Now they have weeks to negotiate over the scheduled higher tax rates and spending cuts known as the fiscal cliff.
Originally published on Thu November 8, 2012 10:15 am
Several thousand prisoners in California may be eligible to apply for sentence reductions, after voters overwhelmingly approved a ballot initiative Tuesday that alters the state's controversial three-strikes law.
But voters also rejected a proposition that would abolish the death penalty in the state. Proposition 34 would have replaced capital punishment with life imprisonment without the possibility of parole.
Originally published on Thu November 8, 2012 10:47 am
In an election that highlighted the political divide over abortion, female voters turned out to be a key to victory for President Obama.
Public outcry over Republican Todd Akin's comments on "legitimate rape" ultimately gave Democrat Claire McCaskill a U.S. Senate victory in Missouri. And in Indiana, Republican Senate hopeful Richard Mourdock lost his race at least in part because of his comments about pregnancy resulting from rape.
The Republicans' comments pushed the abortion issue to the forefront — and also united and motivated abortion rights activists.
The 2012 election was very close in the popular vote, but it was a real blowout in the Electoral College, and that has Republicans sifting through the results for lessons for the future.
NPR's Mara Liasson reports.
MARA LIASSON, BYLINE: Republicans have lots of theories about why they lost on Tuesday. In the months ahead, there will be even more soul-searching and maybe even some renewed family feuds.
Unions poured millions of dollars into ballot campaigns to guarantee collective bargaining rights in the Michigan Constitution and allow state-paid home care assistants to organize into a union. Both were resoundingly defeated.
Originally published on Fri November 9, 2012 7:00 am
NPR's business news starts with a whole bunch of insurance plans.
INSKEEP: Maybe also some auto industry stimulus here. As many as a quarter million cars and trucks damaged when Sandy stormed up the East Coast will have to be scrapped. That's according to the National Automobile Dealers Association. The estimate is less than the 325,000 cars ruined by Hurricane Katrina, but it's still an awful lot of cars.
Nelson Mandela, the anti-apartheid leader and first Black President of South Africa, is also the first Black person to grace South Africa's currency. The country's first Mandela bills were put into circulation Wednesday.
Opposition groups working to bring down the regime in Syria are meeting in Doha, Qatar in a furious bid to reorganize and reinvigorate themselves. The aim is to form a legitimate government in exile that would be recognized by the international community. This new effort to bring together the Syrian opposition is strongly backed by the U.S. NPR's Kelly McEvers is in Doha and joins us to talk about it.
And let's start by you telling us exactly who is there.
It's MORNING EDITION from NPR News. I'm Steve Inskeep.
And I'm Renee Montagne.
Last night, a nor'easter blew hard along the coast bringing new misery to those in New York and New Jersey, already without heat, power or, in some cases, a place to live.
We're joined now for more on that storm by NPR's Martin Kaste who's in Atlantic City, New Jersey. Good morning.
MARTIN KASTE, BYLINE: Good morning.
MONTAGNE: Tell us where you are and what you're seeing, Martin.
From the opening chugging guitar sound, this song could only be The Rolling Stones. For the first time in seven years, Mick Jagger, Keith Richards, Charlie Watts and Ronnie Wood got together to record two new songs, and you can hear "One More Shot," which was recorded in Paris with Don Was producing, right here.
Originally published on Thu November 8, 2012 2:51 pm
When Stephen Wheeler realized he had an aching, swollen finger, he called his primary care doctor, who works for MedStar Health. The doctor referred him to PromptCare, an urgent care clinic in a strip mall in the Baltimore suburbs.
Wheeler says he probably would have ended up waiting a long time if he'd gone to the doctor. And even longer at the emergency room.
Originally published on Thu November 8, 2012 2:52 pm
A couple hundred years ago. hard apple cider used to be the drink of choice for thirsty Americans. It was easy to make and easy to find. But as people moved into cities, and beer became more popular, cider fell out of fashion.
Now it's come roaring back. U.S. hard cider sales are up 65 percent over last year, and just about all the big beer companies sell it, as well as many artisan brewers. Finding cider at your local bar is often no longer a problem.
Although voting problems in Tuesday's election were fewer than some people had expected, there were extremely long lines at many polling sites; so many that President Obama noted them in his victory speech.
"I want to thank every American who participated in this election, whether you voted for the very first time, or waited in line for a very long time," he said, adding, "by the way we have to fix that."
Originally published on Thu November 8, 2012 2:50 pm
With the election over, attention in Washington has turned to the nation's debt and deficit challenges — most immediately the looming fiscal cliff. That's the $600 billion worth of expiring tax breaks and automatic spending cuts set to start taking effect Jan. 1.
The president and Congress agreed to those automatic measures to force themselves to find a more palatable compromise to rein in deficits. On Wednesday, there was an attempt to jump-start that process.
President Obama's re-election and the retention of a Democratic majority in the Senate means the likelihood of a repeal of the Affordable Care Act has receded.
So what now?
"The law is here and we should at this point expect it to still be here Jan. 1, 2014," says Alan Weil, executive director of the nonpartisan National Academy for State Health Policy.
Originally published on Thu November 8, 2012 9:18 am
The same brain system that controls our muscles also helps us remember music, scientists say.
When we listen to a new musical phrase, it is the brain's motor system — not areas involved in hearing — that helps us remember what we've heard, researchers reported at the Society for Neuroscience meeting in New Orleans last month.
Originally published on Thu November 8, 2012 10:27 am
As we near the end of another year, the music industry has a few reasons to be optimistic. Digital music sales are expected to reach record highs this year, and legal streaming services continue to gain in popularity. But unauthorized music file sharing is still going strong.
The man behind the anti-Islamic video that is believed to have sparked protests in the Muslim world was sentenced Wednesday to a year in prison for violating the condition of his probation.
Here's more from The Associated Press:
"U.S. District Court Judge Christina Snyder immediately sentenced Mark Basseley Youssef after he admitted to four of the eight alleged violations, including obtaining a fraudulent California driver's license.
Originally published on Wed November 7, 2012 3:46 pm
Republican strategist Karl Rove's on-air refusal to accept his own network's election night call putting Ohio in President Obama's win column dominated the blogosphere Wednesday.
And, why not? Rove's Crossroads political money empire had showered Republican candidates with close to $300 million this election cycle, a funding gusher courtesy of the 2010 Supreme Court's Citizens United decision and other recent court decisions.
Originally published on Wed November 7, 2012 6:49 pm
Normally, the nor'easter bearing down on the Northeast on Wednesday wouldn't be a tremendous cause for concern. But the storm, delivering snow, sleet and wind gusts of up to 60 miles per hour, is expected to hit parts of Long Island and New Jersey still reeling from Hurricane Sandy.
You swore your allegiance. You voted. Perhaps you even volunteered your time. But your candidate just lost. What do you do now?
Some psychologists say you can look to the coping tactics of die-hard sports fans, who generally have to deal with defeat more than once every four years.
Play the blame game: You can blame the defeat on someone or something other than your candidate, says Tufts University associate professor of psychology Sam Sommers. In sports, you can blame factors like weather, an injury, or — most often — the referees.
Originally published on Tue December 18, 2012 12:11 pm
I saw forty shows during the CMJ Music Marathon this year, and the one by the Brooklyn-based band People Get Ready was by far the most creative. Part of what I love about the band is the way its members think outside the box ... way outside the box. For brevity, I'll describe People Get Ready, led by guitarist, dancer and choreographer Steven Reker, as an indie-rock-performing-art-dance troupe. This is magical musical theater.
Originally published on Wed November 7, 2012 3:50 pm
This presidential election attracted $1.5 billion in outside spending — TV ads, robocalls and other political activity by groups created to take advantage of the new rules of campaign finance law.
On the day after the voting, the track record of the groups, most of them conservative, is open to question.
Tuesday night was a rough one for Karl Rove. The GOP guru is the guiding light and chief fundraiser for the biggest outside spender: the twin groups American Crossroads and Crossroads GPS.
In the Election Day scramble you might have missed that Pfizer got a new drug approved for rheumatoid arthritis.
Pfizer expects the twice-a-day pill called Xeljanz will be available in pharmacies later this month.
The drug won't come cheap. The wholesale price will run about $2,000 for a month's supply, the company says.
We report on the morning after the election in Ohio, a pivotal swing state in the presidential election.
In historic moves, Colorado and Washington state voted to legalize recreational use of marijuana on Tuesday. Its sale will be regulated and taxed, with some of the money going for drug education.
Even during the heat of the campaign, a bipartisan group of eight senators was meeting to try to hash out a framework for deficit reduction to steer clear of that fiscal cliff. The so-called Gang of Eight - four Democrats and four Republicans - includes Senator Mark Warner, Democrat of Virginia, who joins me now. Welcome to the program.
SENATOR MARK WARNER: Thanks for having me, Melissa.
Originally published on Wed November 7, 2012 8:56 pm
An Election Party With A Soundtrack


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Marketing / PR job in Environment
Find the latest Marketing / PR job in Environment to view and apply for now with Guardian Jobs. To have your ideal Marketing / PR job in Environment sent to you the day it's posted, sign up for Jobs by Email. Join our Guardian Sustainable Business Network today and make sure you keep up to date with all you need to know in your industry.
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Events Assistant
- London
- Competitive plus benefits
Guardian News & Media Ltd is one of the most successful and innovative media organisations in the wo...
- Employer: GUARDIAN NEWS AND MEDIA
Digital Engagement Executives, Brand & Engagement Marketing team
- London
- Competitive
This is an extremely exciting opportunity to help develop reader relationships with our journalism, across all content areas covering fantastic events such as Glastonbury and big news moments
- Employer: GUARDIAN NEWS AND MEDIA
Community Fundraising Intern
- Wakefield
- Unpaid Voluntary Work
We're a busy team in a national charity and are looking for a high quality applicant capable of making an impact in our successful team.
- Employer: SENSE
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One arm dumbbell row proper form
Posted in Uncategorized on July 8, 2011
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For a compact exercise space take into consideration the Bowflex Xtreme two SE. This compact still productive unit presents 210 kilos of strength rod resistance. The resistance strategy to lifting weights is better in the joints and bones compared to absolutely free weights. One is not going to endure any undue emotional tension over the joints with resistance exercise tools.


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BAY CITY -- Bay City leaders are working with the police department to address safety concerns in light of this past weekend's brawl early Sunday morning on Midland Street. You saw the explosive web video of the street fight on a story that broke on NBC25 News at 6pm on Monday.
City Commissioner Kevin Novellino has been pushing the issue ever since he shot the now infamous video, involving crowds that attended the Westown nightclub. He talked with Police Chief Michael Cecchini on Monday following the incident.
"He's working on ordinances," Novellino said.
The new rules would place more responsibility on bar owners and the crowds they draw into their establishments. Novellino said this past fight was one of many that have developed in the last year, largely from crowds frequenting Westown on nights that hip hop music is featured. He thinks there is a connection.
"In a lot of large communities where you do have the hip hop music playing, they tend to experience an up tick in violent crime and assaults." NBC25 spoke with the bar's owner, Jay Samborn, off camera Monday afternoon. He said their hands are tied once the crowds spill into the streets.
Westown is not the only bar to play hip hop music. Several other establishments play that form of music if they don't have a live band performing to entertain the crowds. Meanwhile city officials are also addressing the decrease in police presence with recent cuts made to the department this past summer.
"I know we had to rely on the (Michigan) State Police and Sheriff's office while police went to take care of another event in the city," said City Commissioner Kathy Newsham, who represents the ward that includes Midland Street. That event was a shooting.
NBC25 will continue to follow this story.
Related Links


text: The new Grails plugin appears to create an application and deployment with the same name and defaults to a "single instance." Is there any current way to configure a specific deployment (i.e. Multiple Instances with Auto Scaling) and still use the Grails plugin to upload a new application and deploy to multiple instances?


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Updated at 4:49 pm on 28 December 2009
The son of Libyan leader Muammar Gaddafi is believed to be on holiday in New Zealand.
It's understood Saif Al-Islam Gaddafi was on board his father's private jet, which landed in Christchurch on Monday.
The four engine Airbus A340, with four nines emblazoned on the tail, is the same plane used to fly the convicted Lockerbie bomber Abdulbaset Ali Al-Megrahi back to Libya earlier this year.
A spokesperson for the Ministry of Foreign Affairs and Trade confirmed a member of the Gaddafi family was expected in the country for a private visit.
Al-Megrahi, who was convicted of planting a bomb on the Pan Am jumbo jet that exploded over Scotland in 1988, killing 270 people, was released from a Scottish prison on compassionate grounds in August because he has terminal cancer.
Saif Gaddafi played a key role in securing his release and accompanied Al-Megrahi on that flight.
Copyright © 2009, Radio New Zealand
Audio is categorised based on the frequency of the programme it was heard in. Click on the headings below to access the programmes. For the most recently published audio, go to the latest audio page.
Streams are in Windows Media format. Mac and Linux users may need to install additional software. Get help with audio
A selection of music interviews, reviews, videos, concerts, sessions, and performances.
Downloads and podcasts are available for selected programmes. Our podcast page has a complete list of feeds.
Help on using online audio: formats, software, podcasts, downloading, and troubleshooting.


text: Refillable Epson Ink Cartridge Design UpgradesThe photos on the site are a representation. They may not be an exact match to the cartridges you will receive. (The reusable cartridges are the only ones which have not changed over the years and we only get them from one supplier.) We have found that for regular and refillable cartridges, we must deal with several suppliers because at times one or the other runs out of stock. This means variations in design. Design upgrades have also been made, sometimes at our express request. Here are a few examples:Old design: The older design had a glue-on plastic clip. After a number of times of being inserted and removed, this clip could break. Because the cartridges were not individually shrink-wrapped, the clips sometimes broke during shipping. Because these cartridges are completely filled (unlike Epson which are 3/4 empty), temperature and changes in air pressure could cause the ink to leak. A leaky cartridge could create a mess. A clear plastic plug filled the air hole, which must be open in order for ink to flow. Despite putting this in our instructions and in the email sent to customers and on the back of the business card sent with each order, people often forgot to remove this plug and then called to report the cartridges weren't printing. New design: The new design has a clip which is embedded into the cartridge. So far we have not had a single one break out of thousands sold. The cartridges are individually shrink-wrapped, which means a leaky cartridge will stay contained in its wrapping and not create a mess. Instead of the plastic plug, the air hole is covered with the same yellow tape customers are already used to removing. |


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Category Archives: Draft
Keith Law on Parker Markel
The venerable Keith Law attended Hudson Valley's game last night, and apparently took a liking to the night's starting pitcher, 39th-round selection Parker Markel. While the blog itself is behind the Insider wall, most of Law's Markel comments lay outside … Continue reading
The International Arms And Other Links
Not sure if anybody else has realized this, but the Rays international efforts have paid off in pitching depth. Prior to 2006, the Rays had minimal presence outside of the continent, now, there is a case to be made that … Continue reading
Rays Sign Jeff Ames and James Harris
Per Jim Callis, the Rays have signed Jeff Ames for $650,000—or less than the recommended slot value of $803,000. The Rays also signed James Harris, according to MLB Trade Rumors, for $490,000, or over $115,000 under slot value. Click here … Continue reading
Baseball America's List of Draft Picks Signed
Doesn't appear complete, as Blake Snell isn't included, but still: Tampa Bay Rays Draft picks signed: RHP Andy Bass (18), RHP Brooks Belter (25), RHP Dan Bream (33), RHP Zach Butler (34), RHP Charlie Cononie (24), RHP Luke Irvine (27), … Continue reading
Blake Snell and Kes Carter Sign
Per Jim Callis of Baseball America, Blake Snell received $684,000 and Kes Carter received $625,000. The slot recommendations for those spots are around $684,000 and $644,000 , so Carter signs for under slot. Callis also hinted that more Rays signings … Continue reading