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The Conduit: Special Edition Wii
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The Conduit takes players into a dark story in Washington D.C. after a vicious alien invasion has rocked the country… See more
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The Conduit: Special Edition Product Details
Released on 10/07/2009
This special edition includes:
- Embossed and silver-effect slip case
- 20 page hints and tips guide which will be packed into the slip case alongside the standard boxed game
- 3 unlockable items
- Re-skinned all seeing eye
- Agent skin for multiplayer
- Drone skin for single player
The Conduit takes players into a dark story in Washington D.C. after a vicious alien invasion has rocked the country. An organisation called the Trust has sent in Secret Service agent, Mr. Ford, to go up against the insect-like alien race known as "The Drudge." Armed with an array of futuristic weaponry and an intelligence-gathering device simply called the "All-Seeing Eye," players follow an intricate maze filled with conspiracy, shady government activity and terrifying aliens.
The Conduit's detailed control system allows players to customise and configure their controls, including look sensitivity, turning speed, the dead zone and much more. As players delve further into the mystery behind the extraterrestrial invasion, shocking details reveal that the invasion may have been brought on with help from the government itself.
Powered by High Voltage Software's groundbreaking Quantum 3 engine, The Conduit ensures that players will experience single and multiplayer gameplay with graphical fidelity never seen before on the Wii. The Conduit will also support the recently announced Wii Speak peripheral, allowing online multiplayer gamers the ability to chat as they destroy aliens in each terrifying level.
Aliens invade Wii
Although the Nintendo Wii has played host to some of the most innovative and family-friendly titles released for the current generation of consoles, hard-hitting fare aimed at squarely hardcore gamers has been a little thin on the ground.
True, there have been a couple of controversial titles, such as Manhunt, which proved a slightly odd fit for the Wii, and also a number of war-based first-person shooters, namely Call of Duty and Brothers in Arms. All of these were very welcome. However, when it comes to a proper, full-on, sci-fi based shooter with comprehensive multi-player options, Wii owners have been left wanting.
High Voltage shooting
Happily, the release of The Conduit changes all that. Developed by High Voltage Software and published by Sega, this might just be the title which persuades the hardcore contingent that the Wii truly does offer something for everyone.
This might just be the title which persuades the hardcore contingent that the Wii truly does offer something for everyone.
When it comes to Wii titles, The Conduit is unique as, rather than just being a port of a multi-platform franchise, it was designed specifically for the console from the ground up. In effect it's a totally original game, with its own storyline and, crucially, running a graphics engine that's been developed to make the very most of the Wii's hardware. But does that make it any good? Well, yes, it does.
Invasion imminent
The Conduit sees the Earth under threat from a possible alien invasion and Special Agent Ford recruited to take them on by a mysterious organisation named The Trust.
The game looks amazing and features many intriguing plot twists.
If the story is a little unoriginal, the developers have covered this with top-class presentation. The game looks amazing and features many intriguing plot twists. There are also some great cut scenes, professionally-voiced by stars from such TV series as Hercules and Battlestar Galactica.
Cool control system
The Conduit plays extremely well, as High Voltage has managed to finally crack the problem of running a fully-featured first-person shooter on the Wii Remote by providing highly customisable control settings. Almost every control aspect is adjustable to your liking, which is just as well because you're going to find yourself in a lot of sticky situations.
Through the game's nine levels you'll encounter enemy forces, aliens, a scattering of simple navigational puzzles and, most importantly, will get to use a range of human and alien weaponry, which is always a good giggle.
Blast a friend
The single player mode is, in truth, a little short, but the online, multi-player options more than makes up for it. There are many interesting maps, approaching 20 weapons and an enjoyable selection of deathmatch and team-play play modes on offer, including the interesting Bounty Hunter, which obliges you to hunt down a specific target. The multi-player option can handle up to 12 gamers and, what's more, also allows you to also engage in live conversations using Wii Speak.
The Conduit is a breath of fresh air for Wii owners, and makes an effective case for other developers to start producing such titles for Nintendo's versatile box.
GAME's Verdict
- Designed for Wii
- Good looks
- Atmospheric cut scenes
- Excellent controls
- Excellent multi-player mode
- The short story mode
Review by: Simon 'Alien DNA' Kirrane
Version Tested: Wii
Review Published: 02.07.09Published: 02/07/2009
GAME chats with two of the guys behind the Wii's next big thing...
The Conduit is the Wii's latest attempt to make motion sensing the new way to play First-Person Shooters – and Sega's latest effort to bring hardcore gaming to the casual Wii audience. To find out more about it, we sat down with two of the head guys from Conduit developers High Voltage Software; Creative chief Eric Nofsinger and CEO Kerry Ganofsky.
Can you start by telling us a bit about The Conduit? Give us the intro.
Eric: What we're attempting to make is the definitive First-Person Shooter for Wii.
In a nutshell the story is that you play as Michael Ford, a secret agent inducted into a shadowy organisation known as The Trust – sort of our Illuminati type group. You're sent into what appears to be a terrorist attack, but quickly reveals itself to be a full-scale alien invasion, and conspiracy and mayhem ensue!
Did you have a story to tell, or a game you wanted to make, or both?
Eric: We mostly wanted to make a game that was of very high quality for the Wii. It was an option for us to create something original from scratch and we wanted to take advantage of everything the Wii could do. Everything then came together in tandem – the setting; the story; the gameplay. It's all come together very nicely.
Kerry: Accessibility was important. Being able to not only attract core gamers. Nintendo users are very passionate and they remember games like Perfect Dark and Goldeneye. But we also wanted to introduce the FPS to a wider audience; reach out to the 50 million-plus users of the Nintendo Wii worldwide and show that there IS quality software out there for the system.
Why a hardcore game on the Wii – do you think there's a market for it?
Eric: Absolutely! There's a sad misnomer that Wii owners don't want this kind of thing. However, there really hasn't been any of this kind of thing. The majority of core games tend to be more mature-oriented boutique games; niche games.
Core is all about variety, depth of gameplay, replayability, customisation – really listening to what the core gamer expects. Accessibility is what the mainstream wants. I don't think those are necessarily at odds in the First-Person Shooter genre. Games like Halo have proven you can satisfy a couple of different groups. I think The Conduit does an admirable job of balancing the two.
Kerry: I think party games are considered the dominant titles on the Wii because no-one's really stepped up and done something like this exclusively for the Wii. There's a big market out there for The Conduit. Sega and High Voltage have done their jobs, now truly it's the consumer that can actually change the entire landscape of Wii software. Not just for High Voltage and Sega, but also for the Wii community.
Eric: Many publishers are looking at how The Conduit is going to do to see if they should invest in hardcore games on the Wii. If you want another party game, or another game with 'sports' or 'fit' in the name, don't buy The Conduit. If you want something that's high quality where people are trying to push the graphical and technical capabilities, and just the fun aspect, then The Conduit is your game.
The Conduit's control system is obviously unique – not many games have tried it on Wii. How does it work?
Eric: Our control input is a simple point-and-shoot interface where you use the Wiimote to aim and fire, and you also do a quick jab to do melee attacks. Your Nunchuk directional stick moves you around, and you do a quick toss with the Nunchuk to throw a grenade.
That's our basic controls, but the important part is The Conduit's controls are all highly customisable. Core players can remap their controls, change the bounding box, cursor sensitivity, turning speed, modify their HUD (Heads-Up Display) elements. All of these things are enumerated, so Conduit players can share them with their friends. Controls are saved to your profile and copy back and forth between singleplayer and multiplayer.
That goes neatly into my next question! The Conduit's Multiplayer – can you tell us a bit about that?
Eric: We've got a very robust multiplayer and singleplayer in The Conduit. We've 13 multiplayer modes which is a nice variety. We've hit the standards of Deathmatch, Team Deathmatch and Capture The Flag, and a lot of variants and obscure oddities, and hopefully new Conduit-specific favourites.
In The Conduit's singleplayer there's nine missions, and there's a lot of content to unlock; an achievements system as well as a ranking system, which is used in multiplayer. That's used for matchmaking, so you can play with players of a similar level. We've given a lot of thought to making The Conduit as inclusive but also challenging and rewarding to as many players as possible.
Which other FPS games do you guys play and admire?
Eric: Oh gosh, where do you start!
Kerry: There's so many bodies of work that you could draw from. Whenever anyone compares The Conduit to Perfect Dark or Goldeneye, it's flattering to be compared to such wonderful works of art in our industry. I enjoy Halo, the entire Call of Duty series...
Eric: Medal of Honor; Left 4 Dead; Resistance; Gears of War… there's SO many great First-Person Shooters out there. Sadly, none residing on the Wii. So we're hoping to be the first there.
There's been 12 First-Person Shooters on the Wii, six of which are World War II themed, the majority of those 12 are ports, only two of which have received any rankings above 80% - one of which is Metroid, which is frikkin' amazing, but it's also an adventure game and is lumped in with FPS's because of it's perspective. Not so much that it has online multiplayer and the other things that FPS fans expect. The other is Call of Duty: World at War, which is a respectable game, but a port from PSP which doesn't take advantage of the technical and graphical capabilities of Wii like The Conduit does.
Talking of technical capabilities... will we see The Conduit ported across to the other systems with graphical enhancements?
Eric: Not a chance. We have no interest in doing that with The Conduit – this is a game that was made for this system and this control interface. Graphics are one component of a First-Person Shooter and they're very important to fans – hardware sales of graphics cards and computers over the years certainly point to the importance of graphical fidelity.
However, gameplay is really why we opted to make The Conduit on the Wii. We believe the controller interface we have in The Conduit could do for Wii what Halo did for Xbox, in that it pulled people over to a new way of playing First-Person shooters. Before that, people thought PC with mouse and keyboard was THE way to play First-Person shooters. Now you have many people who prefer dual analogue sticks. We're hoping to pull in a new breed of First-Person Shooter fans.
We've seen first-hand at tradeshows and community events where people who have never played an FPS on any console pick up the controller and in the first few minutes feel like they're accomplishing something – that's before Kerry and I come in and blow their heads off, anyway!
Kerry: [laughs]
Eric: Seriously though, giving players the chance to accessibly interface with First-Person Shooters for the first time – I think that will be healthy for the shooter community at large. We hope The Conduit is the game that can spark that. We hope to have many imitators after us.
Kerry: Having said that, having that shallow difficulty curve of a robust control system and that physicality of aiming, melee thrusting and throwing grenades – from a gameplay perspective that's outstanding for the hardcore. We're hoping The Conduit will define the next step for First-Person Shooters on Wii.
Do you also see The Wii and a game like The Conduit as educating people as to what games are really about – not just being a toy, but being serious entertainment?
Eric: I think the Wii's an interesting beast, and we're really proud to have made The Conduit for it. I think there is a perception that the console is a toy, primarily because of the products available for it, but I think it can be more than that; a truly immersive, entertainment device that can reach out to people in a different way. I hope we play a small part in that – and I think we can with The Conduit.
There's space for both things, and certainly for higher quality products on the Wii. Whether they're casual games or full-blown First-Person Shooters, there's definitely room for improvement – and if nothing else, I hope people support the Conduit so that they'll see more games done to a high quality standard. Whether it's shooters or brawlers or platformers, the Wii is capable of a lot more than developers and publishers are doing right now.
Couldn't agree more. Cheers guys.
Interview by: Mark Scott
Interview Published: 14.05.09Published: 14/05/2009
When Nintendo's Wii was first released there were two gaming genres people thought it could potentially revolutionise. One was sports games – particularly tennis, golf, cricket... anything where the Wii Remote could mimic a real sporting object. The other was First-Person Shooters – but after some wayward attempts, only Metroid Prime 3 has come close to accurate point-n-shoot gameplay. And that's more of an adventure than a Halo-style 'proper' FPS.
Any hopes of a motion-sensing FPS Wii revolution are now carried, almost single-handedly, by High Voltage's Software's latest effort The Conduit. Could this catapult the Remote and Nunchuk to the forefront of shooter gameplay? And just as importantly, might The Conduit give the party-game-swamped-console a real hardcore, gamer's game to shout about? I headed to Sega HQ to investigate.
Coming to The Conduit from a regular diet of next-gen FPS's (most recently Riddick), the most obvious point of contention is its looks. Wii simply doesn't have the power to compete graphically with HD systems, and anyone expecting top-end visual bombast will be disappointed by The Conduit's jagged edges and washed out colour palette. By Wii standards, however, The Conduit is an impressive looking game, with atmospheric lighting, lots of texture detail and pretty smooth framerate, no matter how much is happening on-screen.
The Conduit has that pick-up-and-play feeling that the Wii is famous for, and it wasn't long before I was walking, aiming, jumping and firing.
And it's certainly frenetic in multiplayer, which is where my hands-on with The Conduit began. The good news is that The Conduit has that pick-up-and-play feeling that the Wii is famous for, and it wasn't long before I was walking with the Nunchuk stick, aiming by tilting the Remote, jumping with A and firing with the B trigger.
The best bit though is that turning also felt natural. Unlike Wii launch FPS Red Steel, which allowed you to move the targeting reticule right across the screen and only turned your character when it hit the very edge (making it feel like you were waving a disembodied arm around) The Conduit responds to slight movements of the Wiimote to move the reticule within the middle portion of the screen, and noticeably larger movements to turn your head. It means that The Conduit controls like a twin analogue stick FPS, with more finely tuned manual aiming and overall quicker movement.
Control freak
With the basics down, I encountered my first problems with the more in-depth controls. Melee attacks are activated with a forward thrust of the Wii Remote – but because the Wiimote also moves the character's head, there were instances where it didn't register the thrust, and I'd just end up looking at the floor, dying frustratingly in the midst of a multiplayer skirmish.
That said, flicking the Nunchuk to throw grenades worked intuitively, as did quick-turning with up on the d-pad (though this was hard to reach), sniping with down (which felt VERY sensitive), swapping weapons with left and right, and crouching by holding C on the Nunchuk. Interestingly, The Conduit also has the option to lock on to foes with the Z button, which somewhat negates the Wiimote's more precise aiming, but should enable casual players to get their head around the controls – which can always be fully customised if you still can't click with them.
A few people at the press event mention the hallowed Goldeneye, but for me it felt more like that game's N64 follow-up, Perfect Dark.
Controls aside, how does the whole experience feel to play? Well, a few people at the press event mention the hallowed Goldeneye, but for me it felt more like that game's N64 follow-up, Perfect Dark. The Conduit's whole shtick is that Earth has been invaded by an alien race called The Drudge, and the two weapons sets – human projectile/explosive firearms and alien beam weaponry – plus The Conduit's tendency to mix settings like sewers, city streets and sterile labs with lots of glowing neon lights and futuristic tech was decidedly reminiscent of Joanna Dark's escapades.
One thing The conduit does do uniquely is its multiplayer voting system. Again, the weapon types and the feel of the levels – lots of smallish maps and enclosed spaces – is PD-esque, but every person playing gets to choose a level, gametype and weapon set, and the most popular wins. There's standard free-for-all and team deathmatch modes in there, and also one called the All Seeing Eye, in which the person who holds on to the A.S.E. (which looks like a metallic Magic 8 Ball) the longest wins the match, like Halo 3's Oddball.
The A.S.E. also made an appearance in my brief two-level bash at the story campaign, which saw me taking control of rookie agent Michael Ford and battling robots, aliens and brainwashed human agents in underground tunnels and at an airport. It was action-packed and enjoyable, if somewhat linear – although using the A.S.E to find hidden alien nodes and open doors did add some variety.
Can the Conduit revolutionise FPS gaming? In all honesty it's unlikely – but the chances are that it will bring robust story-driven and online multiplayer action to a console crying out for exactly that. Watch this space...
Preview by: Mark 'All Seeing Eye' Scott
Preview Published: 08.05.09Published: 08/05/2009
The Conduit Review (02/07/2009)
Aliens invade Wii
Although the Nintendo Wii has played host to some of the most innovative and …
See more about 'The Conduit Review'
The Conduit Wii Interview (14/05/2009)GAME chats with two of the guys behind the Wii's next big thing...
The Conduit is the Wii's latest attempt to make mo…
See more about 'The Conduit Wii Interview'
The Conduit Preview (08/05/2009)The Conduit Preview…
The Conduit: Special Edition User Reviews3 years agoThe Conduit: Special EditionWell before i brought this game from reviews i have read u either love the game or hate it and i love it!I mainly brought the game for multiplayer which is excellent and i am already at lvl 10. There are aronud 15 games to play however the are very similar with minor differences.The controls you can change to your preferences and i changed them to the most i could towards COD controls.. I decided then to try the campain and if u want the game for that you wont lose out. although there are no real big baddys to kill the gameplay and controls are brilliant. However the online play might be great but the will speak isntthe best on the game as you cant talk to public people and only talk to people that are in your game that are on your friend list. Aswell as this i thought the game was gong to be £30 but when i got to the shop i found it was £38.Overall the game is probally the best game i have ever played on the wii!!3 years agoThe Conduit: Special EditionExcellent game very engaging and lot's of fun3 years agoThe Conduit: Special Editiongood gameso far played the day after it arived luckly i bought it when i did i think i got the 1 of the last ones lol3 years agoThe Conduit: Special EditionThis is a great FPS game for wii a bit better than cod 5. You have tooo get THIS!!3 years agoThe Conduit: Special Editiongreat game have realy enjoyed it and rather good graphics for a wii gameConfiguring your price alertAs a valued customer we now offer you the facility to sign up to email price alerts. Please enter the price you want to be, or below, and if drops to that level we will let you know...
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PRCA rejects Government's definition of a lobbyist
London, 13th April – In response to the Government's consultation on a proposed statutory register of lobbyists the PRCA has rejected the Government's narrow definition of a lobbyist that includes only those who represent third parties.
Following an extensive consultation with its members, the PRCA has proposed a definition of a lobbyist as a professional that deliberately and intentionally conducts the 'act of lobbying', rather than focusing on the profession of the individual itself.
A definition that focuses on the act rather than the profession will ensure that all lobbyists will be placed on the register. This will include professionals that lobby as part of in-house teams, think tanks, trade unions, NGOs, and trade association bodies such as the PRCA.
This definition was produced following a survey of PRCA members that overwhelmingly stated that the Government's definition was unsuitable. Members also made this clear to the Minister for Constitutional Reform, Mark Harper MP, at the Public Affairs Group meeting on the 26th March.
Francis Ingham, PRCA Chief Executive, said: "Getting the definition right is crucial to creating a register that promotes transparency and produces public trust in our industry and the political institutions they lobby. Unfortunately the Government's proposed definition is worryingly narrow and therefore unfit for purpose".
To read the PRCA's full response to the consultation please click here: PRCA Consultation Response
To see Francis Ingham's oral evidence to the Political and Constitutional Reform Select Committee from last month please click here: PCRC 15th March
Following the consultation, the Government expects to produce a White Paper with draft legislation included at some point this year. Mark Harper MP made it clear at the PRCA PA Group meeting that there will be a statutory register in place by the end of this Parliament.
Notes to editors
Tom Hawkins, Policy and Research Executive
T: 020 7233 6026 ¦ E: email@example.com
About the PRCA
Who we are: Founded in 1969, the PRCA is the professional body that represents UK PR consultancies, in-house communications teams, PR freelancers and individuals. The PRCA promotes all aspects of public relations and internal communications work, helping teams and individuals maximise the value they deliver to clients and organisations.
What we do: The Association exists to raise standards in PR and communications, providing members with industry data, facilitating the sharing of communications best practice and creating networking opportunities.
How we do it and make a difference: All PRCA members are bound by a professional charter and codes of conduct, and benefit from exceptional training. The Association also works for the greater benefit of the industry, sharing best practice and lobbying on the industry's behalf e.g. fighting the NLA's digital licence.
Who we represent: The PRCA represents many of the major consultancies in the UK, and currently has more than 250 agency members from around the world, including the majority of the top 100 UK consultancies. We also represent over 70 in-house communications teams from multinationals, UK charities and leading UK public sector organisations.

subset: commoncrawl


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i am interested in doing a juice fast for the first time and i am not 100 percent raw yet. my juicer will be arriving any day now, but while researching juice fasting i have seen information on green smoothies which are made in the blender? also, i have read about the green energy soups? i have had a hard time switching to raw food meals, most of them send me to the bathroom within a couple hours and then i "go" three or four times a day depending on how raw i am eating. it has been a month now and i think my body is accepting the increase in fiber, i can eat more and more raw each day.
my question is: would it be good to do a short juice fast which is a combo of the soup, smoothie and straight juice or just one type? i also need a book which describes the difference between these types of drinks and how to make different blends(it is getting so confusing and i cant afford to buy a ton of books).
i know i will have to learn how to make combinations which taste good to me, i have read that lemon will cut the bitter taste. i am not too hip on kale and collards, although i love them as a wrap.
my main reason for the fast is weight loss and also i feel it will simplify my life, it just feels like the right thing to try right now. i want to really increase my green intake.
sorry to ramble! need help!


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Perfect Travel Companion
Filed Under (Shoes We Love) by Michelle on 19-11-2012
Tagged Under : Boots, comfort, fall, Flats, heels..com, styles, travel
The busy holiday travel season commences this week and there is nothing worse than being stuck in the car or airport in uncomfortable clothing. Not to mention the dreaded hassle of shoe removal at security. My favorite travel companions are a pair of easy to wear boots or flats, a pair of thick leggings, and cozy layers for that freezing airplane! And if you're going to pack boots, it's best to wear them through the airport to save room in your baggage. Travel in style this holiday season with these comfortable footwear choices from Heels.com.
Naughty Monkey Sandstorm in Taupe


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County extension agent opening posted
By Stephanie Johns
Staff Writer
The Morgan County extension agent position posted to the University of Georgia human resources website Nov. 28. Posting number 20121854 offers job details and requirements.
Bobby Smith, the previous extension agent for Morgan County, resigned effective Sept. 1.
The new agent should have at a minimum a bachelor's degree – a master's degree is preferred – in animal, dairy, or equine sciences, horticulture, natural resources, plant protection and pest management, agriculture, or another closely related area.
Responsibilities include managing the agricultural and natural resources in the county, which the ad notes includes "a Total Farm Gate Value of approximately $120,000,000."
Applications will be accepted through Jan. 1, 2013.
Norman McGlohon, Northeast District Executive Director, said they will set up interviews pretty soon after the closing date.
"It'll take eight to 10 weeks once we get the interviews done to do the paperwork and get them started," he said. "We're looking to fill it quickly."
Printed in the December 6, 2012 edition


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Two southern Illinois counties make strides in online transparencyBy Jayette Bolinski | Illinois Watchdog SPRINGFIELD — A new survey of government transparency on county websites in southern Illinois shows only two counties making progress toward openness. There is plenty of work still to be done, said Brian Costin, director of government reform at the Illinois Policy Institute, a right-leaning think tank that monitors government transparency in the state. "With Illinois' history of corruption, no one in this state should be resisting improving transparency efforts," he said. Union and Madison counties earned top scores in the most recent installment of the institute's "Local Transparency Project," which grades local government websites on how much public data — such as number of employees, salaries, tax rates, budgets, contracts and meeting calendars, agendas and minutes — is available to users. Madison County, in the Metro East, received the only passing grade overall. Union County, in far southern Illinois, showed the most improvement since a review three months ago when it did not have a website. Even though it received a failing grade during the most-recent review, Costin said Union County showed clear improvement in the right direction. State laws, such as the Freedom of Information Act and the Open Meetings Act, provide some guidance for what local governments must post online, but they can go beyond those requirements. Of the 14 southern Illinois counties surveyed by the institute, only Madison and Union were compliant with posting requirements of the two acts. Two other counties — St. Clair and Monroe — were compliant with Open Meetings Act posting requirements but not those of FOIA. Ten counties were not compliant with either. "Unfortunately, it's not just the institute's suggestions that these counties are failing to live up to. Many are failing to comply with basic state laws," Costin said. "Taxpayers should demand for more transparency from their elected officials." Union County Treasurer Darren Bailey said the policy institute's review prompted the county to work on being transparent on its website. "With the current environment of government in Illinois so overcast and gloomy, it is vital that we have programs like (this) breaking up the clouds," he said. The 12 other counties that failed the institute's audit were Bond, Clinton, Franklin, Jackson, Jefferson, Johnson, Madison, Monroe, Pulaski, Randolph, St. Clair, Washington and White. Twelve southern Illinois counties have no official government websites — Alexander, Edwards, Gallatin, Hamilton, Hardin, Massac, Perry, Pope, Saline, Wabash, Wayne and Williamson. The institute has graded more than 250 government sites since 2010, when it launched its transparency project. Contact Jayette Bolinski at email@example.com. |
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The Southington-Cheshire Community YMCAs Gymnastics Department provides quality gymnastic instruction to entry level gymnasts in a fun and safe environment. All of our classes are offered at our 5,000sq ft off site Gymnastics Center that is fully equipped with four Olympic events, spring floor for tumbling, uneven bars, balance beam and vault. Classes are taught by our knowledgeable and enthusiastic instructors.
Our Pre school classes help develop socialization and gross motor skills while teaching the basics of Gymnastics through special themes and circuts. Classes are offered for children 2 years to 5 years of age.
Our School-Age classes provide high quality, skill appropriate gymnastics instruction with the focus on building self esteem, learning new skills and goal setting. Classes are offered for 5 years and up.
The YMCA Gymnastics Team provides a competitive yet fun-filled atmosphere to all age groups in a warm, welcoming, successful family environment with a challenging, knowledgeable and caring coaching staff. Throughout the competition season, we hope to instill in our gymnasts self-confidence, sportsmanship and team work.
Coming this Summer!!!
One week sessions for many of our gymnastics classes.
Take advantage of gymnastics classes in the morning
when it is nice and cool in the gym one week at a time
Look for our summer schedule in the next program guide.


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For the sake of convenience and easy reference, the major areas of development in a child have been grouped according to age.One month profile• Turns towards the source of light, tries to fix his gaze on the mother or any object nearby like a toy, and briefly follows a light source.• A sudden sound may cause stiffening, blinking, stretching, and crying. Stops whimpering on hearing a soothing voice.• Cries in hunger or discomfort and gurgles if contented.• Spends most of his time sleeping but begins to smile socially and makes responsive sounds by six weeks.• Ceases crying when picked up and talked to.Three month profile• Begins to respond better.• While on his back, brings his hands above his chest and seems to study them. Kicks and waves his arms and if put on his stomach, raises head and shoulders.• If he is on your lap, he can support his head and look around.• Can briefly hold a toy; tries to focus on small objects nearby.• Is distressed by sudden noise, but is quietened by a soothing voice.• Vocalises happily when pleased and is excited by the sound of a running tap, footsteps or approaching voice; laughs aloud.• Bath and feeds evoke coos, smiles, and excited gestures. Enjoys being bathed and gurgles happily when picked up or tickled.Six month profile• Begins to sit unsupported with his back straight and rolls over; bounces when held standing.• Grasp has improved and this encourages continual handling of objects, putting everything in his mouth, and transferring objects from one hand to the other.• Makes sing-song noises and two-syllabled sounds like 'a-a', 'na-na'.• Squeals and chuckles, and screams if annoyed.• Delighted if you play with him.• Cuts his first teeth, usually the lower central incisors.Nine month profile• Can pull himself up and stand by holding on to furniture. Has learnt to crawl.• Holds small objects like buttons, coins, etc., between thumb and finger. Can grasp a cup in both hands; can hold, bite, and chew any food.• Can comprehend 'no-no', 'bye-bye'.• Makes noises constantly and repetitively like 'ma-ma', and 'da-da'.• Plays peek-a-boo.One year profile• Begins to stand and walk unaided. Can crawl very fast and can crawl up and down the stairs.• Can hold more than one object in his hands.• Deliberately drops and throws toys, watching them fall.• Can use a cup unaided.• Holds, but cannot use, a spoon.• Recognises people. Understands simple commands.• Turns when called by name.• Uses a lot of jargon. Can speak a few words.• Offers arm or leg for dressing. Enjoys sound-making toys; enjoys playing pat-a-cake. Waves bye-bye.One and half year profile• Runs about, goes upstairs if you hold his hand.• Explores corners; enjoys pulling and pushing boxes and toys; enjoys looking at picture books.• Becomes adept at picking up small objects such as beads; tries to scribble holding the pencil in the palm of his hand.• Carries food to mouth with a spoon, drinks easily from a cup.• Says 15 to 20 words; tries to recite nursery rhymes.• Has bowel control; fidgets and makes agitated sounds when urgently in need of going to the toilet.• Imitates actions like sweeping the floor, dusting, and reading.Two year profile• Loves to run, chase, and be pursued.• Takes things apart, puts them together again; more adept at using his hands -- can hold a pencil between two fingers and the thumb; tries to draw.• Has a fairly large vocabulary.• Has control over bowel and bladder.• Uses his own name to refer to himself; participates in songs and nursery rhymes.• Obeys simple commands; puts on shoes.• Washes hands.• Fiercely possessive about toys; behaves in a jealous manner when parents show interest in another child.• Has all 20 primary teeth.
Child Age Profile, Development in Child, Baby One Month Profile, Child Development Profile, Age Two Development, Child Speech Development, Baby Walk, Child Developmental Milestones, Child Development Age


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Latest MLB
May 24, 2013 5:03 PM
Thursday night, a soccer game was played where the Cardinals usually play baseball. Here's a shot of the stadium.
May 24, 2013 4:34 PM
A 14-year-old girl collapsed in Kauffman Stadium on Thursday night, but an off-duty nurse who works for the Royals was nearby.
May 24, 2013 4:15 PM
For the second time this season, Reds left-handed reliever Sean Marshall has hit the DL.
May 24, 2013 3:58 PM
As he works to return from Tommy John surgery, Braves starter Brandon Beachy will make his first Triple-A rehab start Friday.
May 24, 2013 3:54 PM
Didi Gregorius, the least known key man in Arizona's widely panned three-team trade, is surprising everyone -- maybe even GM Kevin Towers.
May 24, 2013 3:13 PM
It was 78 years ago Friday when Major League Baseball staged its first night game, in Cincinnati's Crosley Field.
May 24, 2013 1:52 PM
Is Manny Machado Alex Rodriguez, or is he Derek Jeter? With three hits in each of his last four road games, he's actually Ty Cobb.
May 24, 2013 1:16 PM
Just for fun, here's what an All-Star team composed of players the Marlins have traded in the Jeffrey Loria era would look like. It's solid.
May 24, 2013 11:41 AM
Here's a GIF showing Tigers slugger Miguel Cabrera hitting a home run on six pitches from outside the strike zone, some far outside it.
May 24, 2013 11:20 AM
After making a catch on Thursday night in which he flew into the stands, Baltimore's Nate McLouth was nearly hit with a thrown beer can. Here's video.
Fantasy Baseball | May 24, 2013 11:05 AM
Which hitters should you be considering for upcoming Fantasy Week 9? Our Scott White takes a close look at all of the streaks and matchups to help optimize your lineups.
May 23, 2013 12:34 AM
With the Monday through Thursday series all wrapped up, it's time to hand out some performance grades.
May 23, 2013 11:45 PM
The folks at Fox Sports Kansas City really screwed up a graphic on Thursday night. Like really, really screwed up.
May 23, 2013 10:00 PM
Ervin Santana is known to give up some homers, but few are hit as far as the ball Mike Trout hit on Thursday.
May 23, 2013 9:23 PM
The Phillies are losing a big bat to injury, as Chase Utley has been placed on the 15-day DL with a 'very mild' oblique strain.
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CBSSports.com ShopBaseball is back! |


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By Tania Flack
Guy: Did you know if your body suddenly disintegrated into a pile of dust, up to 5% of it would be minerals. So as you can imagine, minerals have a major role to play in good health and body functionality.
There is the fear of having too much concentration of minerals which is toxic to the body. But as minerals can only be ingested from external sources, the main problem that arises is mineral deficiency through a typical western diet.
The question to ask yourself is, how do I know if I'm deficient?


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Here's a roundup of today's other search news and headlines from around the web, sorted by category.
Search Industry News
- Google's 1Q Lobbying Bill Hits New High of $1.48M - Associated Press
- Google Sued Over Daily Deal Business Venture - Gametime IP
- Google's inner workings detailed in book - San Jose Mercury News
- Google's Data Shows Hollywood's Headache: Netflix Searches Booming, DVDs Fading Away - All Things Digital
- Google Updates Its Management Page...By Taking Almost Everybody Off It - All Things Digital
- Google talks to Spotify to power music service - CNET News
- Face of Egypt revolution tells Silicon Valley to 'change the world' - San Jose Mercury News
- Two heads are better than one: introducing enhanced collaboration in Google Site Search - Google Enterprise Blog
- Security First: Security and data protection in Google data centers - Google Enterprise Blog
- Long label names in Gmail - Gmail Blog
Search Engine Optimization
- Search For Yahoo Search On Google & Get AllTheWeb - Search Engine Roundtable
- Your fast pass through security - Google Webmaster Central Blog
Search Advertising
- 7 Tips to Filter Out Lame Searches - ClickZ
- Hello, AdWords Topic Targeting! - PPC Hero
- Google AdWords Easter Optimization Tips On Good Friday - Search Engine Roundtable
- How to Optimize Your PPC Campaigns with adCenter Quality Score - adCenter Blog
Social Media Marketing
- Facebook Celebrates One Year Of The Like Button - All Facebook
- Facebook Ads Can Now Include or Exclude Existing Fans in "Friends of Connections" Target - Inside Facebook
- The Tweets of San Francisco - Twitter Blog
Link Building
- You Can't Grow a Blog On Negative Linkbait Alone - Outspoken Media
- Templatized Personalization an Effective Strategy for Link Building - Vertical Measures
Local Search
- Google Places Turns 1: What's Working, What's Not - Small Business Search Marketing
International Search
- Google Probed By Belgian Authorities Over Privacy Lapses - Bloomberg
- Google's China market share: declining - Financial Times
- Investors Searching for Baidu's Next Chapter - The Wall Street Journal
Video Marketing
- Life in a Day - coming to theaters this summer - YouTube Blog
Marketers Rejoice! ClickZ has launched ClickZ Live, an educational series to bring you innovative online marketing strategies and techniques. Learn to construct and successfully execute multi-channel marketing campaigns, plus identify key metrics and translate them into actionable plans.
Thursday, July 18: ClickZ Live will be in Vancouver, BC. Register before July 1 to save $100!


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- Alcoholic liver disease (1)
- Fibrotest (1)
- Hepatitis (1)
- Hepatotoxicity (1)
- Interleukin-22 (1)
- Liver cirrhosis (1)
- Liver enzymes (1)
- Liver-related complications (1)
- Wie wirksam sind neue Therapien für Hepatitis C? : Mathematische Modellierung charakterisiert den individuellen Behandlungserfolg (2009)
- Die derzeitige Therapie der chronischen Hepatitis C ist komplex und mit zahlreichen Nebenwirkungen assoziiert. Um den Therapieerfolg frühzeitig vorhersagen zu können und die Behandlung individuell zu optimieren, greifen Forscher des Frankfurter Leberzentrums auf mathematische Modellierung zurück. ...
- HCV-related burden of disease in Europe : a systematic assessment of incidence, prevalence, morbidity, and mortality (2009)
- Background Hepatitis C virus (HCV) is a leading cause of chronic liver disease, end-stage cirrhosis, and liver cancer, but little is known about the burden of disease caused by the virus. We summarised burden of disease data presently available for Europe, compared the data to current expert estimates, and identified areas in which better data are needed. Methods Literature and international health databases were systematically searched for HCV-specific burden of disease data, including incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and liver transplantation. Data were collected for the WHO European region with emphasis on 22 countries. If HCV-specific data were unavailable, these were calculated via HCV-attributable fractions. Results HCV-specific burden of disease data for Europe are scarce. Incidence data provided by national surveillance are not fully comparable and need to be standardised. HCV prevalence data are often inconclusive. According to available data, an estimated 7.3–8.8 million people (1.1–1.3%) are infected in our 22 focus countries. HCV-specific mortality, DALY, and transplantation data are unavailable. Estimations via HCV-attributable fractions indicate that HCV caused more than 86000 deaths and 1.2 million DALYs in the WHO European region in 2002. Most of the DALYs (95%) were accumulated by patients in preventable disease stages. About one-quarter of the liver transplants performed in 25 European countries in 2004 were attributable to HCV. Conclusion Our results indicate that hepatitis C is a major health problem and highlight the importance of timely antiviral treatment. However, data on the burden of disease of hepatitis C in Europe are scarce, outdated or inconclusive, which indicates that hepatitis C is still a neglected disease in many countries. What is needed are public awareness, co-ordinated action plans, and better data. European physicians should be aware that many infections are still undetected, provide timely testing and antiviral treatment, and avoid iatrogenic transmission.
- Letalität auf der Warteliste und Transplantation bei Leberallokation nach MELD Score in Deutschland - erste prospektive Ergebnisse bei 100 Patienten (2008)
- Meeting Abstract : Deutsche Gesellschaft für Chirurgie. 125. Kongress der Deutschen Gesellschaft für Chirurgie. Berlin, 22.-25.04.2008 Einleitung: Am 16.12.06 wurde im Eurotransplant-Gebiet der MELD-Score (MELD) als Allokationsbasis zur Lebertransplantation (OLT) eingeführt. Ziel ist eine Reduktion der Sterblichkeit auf der Warteliste. Material und Methoden: 100 Patienten wurden in die prospektive Analyse der MELD-Allokation vom 16.12.06 bis 15.09.07 einbezogen. Ergebnisse: Aktuell warten 68 Pat., 28 Pat. wurden transplantiert, 4 Pat. sind auf der Warteliste (WL) verstorben (4%). Der mittlere MELD auf der WL beträgt 17,2 +/- 5,2 (7-28). Bei 12 Pat. liegt eine Standard-exception (SE) (n=10 HCC, n=2 metabolische Erkrankung) mit einem Match-MELD von 25,6 +/-2,06 vor (24-28). Die Todesursachen der vier auf der WL verstorbenen Pat. waren eine akute Varizenblutung (MELD 9), zwei kardiale Versagen (MELD 13, 18) und eine MRSA-Sepsis (MELD 29, NT-Status). Die 28 transplantierten Pat. hatte zum Zeitpunkt der Transplantation einen mittleren MELD von 27,66 +/- 5,1 Punkten (21 bis 40). 20 Pat. wurden aufgrund des Labor-MELD (28,4 +/- 5,3, 24-40) transplantiert, wobei 7 Pat. einen MELD über 30 aufwiesen. Die Wartezeit lag bei 11,55 +/- 5,3 Tagen. 8 Pat. erhielten bei SE bei HCC (MELD 24 +/- 0, 24) ein Organ nach einer Wartezeit von 320 +/- 9,7 Tagen. Aktuell leben 23 der 28 transplantierten Pat. Bei zwei verstorbenen Pat. war die Todesursache ein kardiales Versagen, bei zwei Patienten eine primäre Non-Funktion sowie ein septisches Multiorganversagen. Schlussfolgerung: Während der ersten Monate der MELD Allokation lag die Letalität auf der WL in unserem Zentrum bei 4%. Patienten mit einem mittleren MELD über 27 erhielten Organangebote und konnten nach kurzer Wartezeit transplantiert werden.
- Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis (2010)
- Background: FibroTest (FT) is the most frequently used serum fibrosis marker and consists of an algorithm of five fibrosis markers (alfa2-macroglobulin, apolipoproteinA1, haptoglobin, GGT, bilirubin). The Enhanced Liver Fibrosis (ELF) test consists of an algorithm of three fibrosis markers (hyaluronic acid, amino-terminal propeptide-of-type-III-collagen, tissue-inhibitor of matrix-metaloproteinase-1). While a systematic review has shown comparable results for both individual markers, there has been no direct comparison of both markers. Methods: In the present study, the ELF-test was analyzed retrospectively in patients with chronic liver disease, who received a liver biopsy, transient elastography (TE) and the FibroTest using histology as the reference method. Histology was classified according to METAVIR and the Ludwig's classification (F0-F4) for patients with chronic hepatitis C and B virus (HCV, HBV) infection and primary biliary cirrhosis (PBC), respectively. Results: Seventy-four patients were analysed: 36 with HCV, 10 with HBV, and 28 with PBC. The accuracy (AUROC) for the diagnosis of significant fibrosis (F[greater than or equal to]2) for ELF and FibroTest was 0.78 (95%CI:0.67-0.89) and 0.69 (95%-CI:0.57-0.82), respectively (difference not statistically significant, n.s.). The AUROC for the diagnosis of liver cirrhosis was 0.92 (95%CI:0.83-1,00), and 0.91 (95%CI:0.83-0.99), respectively (n.s.). For 66 patients with reliable TE measurements the AUROC for the diagnosis of significant fibrosis (cirrhosis) for TE, ELF and FT were 0.80 (0.94), 0.76 (0.92), and 0.67 (0.91), respectively (n.s.). Conclusion: FibroTest and ELF can be performed with comparable diagnostic accuracy for the non-invasive staging of liver fibrosis. Serum tests are informative in a higher proportion of patients than transient elastography.
- A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants (2010)
- Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the evolution and in vivo fitness of variants in subjects dosed with monotherapy of an HCV protease inhibitor, telaprevir. Variant fitness was estimated using a model in which variants were selected by competition for shared limited replication space. Fitness was represented in the absence of telaprevir by different variant production rate constants and in the presence of telaprevir by additional antiviral blockage by telaprevir. Model parameters, including rate constants for viral production, clearance, and effective telaprevir concentration, were estimated from 1) plasma HCV RNA levels of subjects before, during, and after dosing, 2) post-dosing prevalence of plasma variants from subjects, and 3) sensitivity of variants to telaprevir in the HCV replicon. The model provided a good fit to plasma HCV RNA levels observed both during and after telaprevir dosing, as well as to variant prevalence observed after telaprevir dosing. After an initial sharp decline in HCV RNA levels during dosing with telaprevir, HCV RNA levels increased in some subjects. The model predicted this increase to be caused by pre-existing variants with sufficient fitness to expand once available replication space increased due to rapid clearance of wild-type (WT) virus. The average replicative fitness estimates in the absence of telaprevir ranged from 1% to 68% of WT fitness. Compared to the relative fitness method, the in vivo estimates from the viral dynamic model corresponded more closely to in vitro replicon data, as well as to qualitative behaviors observed in both on-dosing and long-term post-dosing clinical data. The modeling fitness estimates were robust in sensitivity analyses in which the restoration dynamics of replication space and assumptions of HCV mutation rates were varied.
- Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms (2011)
- Background: High baseline levels of IP-10 predict a slower first phase decline in HCV RNA and a poor outcome following interferon/ribavirin therapy in patients with chronic hepatitis C. Several recent studies report that single nucleotide polymorphisms (SNPs) adjacent to IL28B predict spontaneous resolution of HCV infection and outcome of treatment among HCV genotype 1 infected patients. Methods and Findings: In the present study, we correlated the occurrence of variants at three such SNPs (rs12979860, rs12980275, and rs8099917) with pretreatment plasma IP-10 and HCV RNA throughout therapy within a phase III treatment trial (HCV-DITTO) involving 253 Caucasian patients. The favorable SNP variants (CC, AA, and TT, respectively) were associated with lower baseline IP-10 (P = 0.02, P = 0.01, P = 0.04) and were less common among HCV genotype 1 infected patients than genotype 2/3 (P<0.0001, P<0.0001, and P = 0.01). Patients carrying favorable SNP genotypes had higher baseline viral load than those carrying unfavorable variants (P = 0.0013, P = 0.029, P = 0.0004 respectively). Among HCV genotype 1 infected carriers of the favorable C, A, or T alleles, IP-10 below 150 pg/mL significantly predicted a more pronounced reduction of HCV RNA from day 0 to 4 (first phase decline), which translated into increased rates of RVR (62%, 53%, and 39%) and SVR (85%, 76%, and 75% respectively) among homozygous carriers with baseline IP-10 below 150 pg/mL. In multivariate analyses of genotype 1-infected patients, baseline IP-10 and C genotype at rs12979860 independently predicted the first phase viral decline and RVR, which in turn independently predicted SVR. Conclusions: Concomitant assessment of pretreatment IP-10 and IL28B-related SNPs augments the prediction of the first phase decline in HCV RNA, RVR, and final therapeutic outcome.
- Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma (2011)
- Background: MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC. Methodology/Principal Findings: 62 CHC patients, 29 patients with CHC and HCC and 19 healthy controls were prospectively enrolled. RNA was extracted from the sera and miR-21 as well as miR-16 levels were analyzed by quantitative real-time PCR; miR-21 levels (normalized by miR-16) were correlated with standard liver parameters, histological grading and staging of CHC. The data show that serum levels of miR-21 were elevated in patients with CHC compared to healthy controls (P<0.001); there was no difference between serum miR-21 in patients with CHC and CHC-associated HCC. Serum miR-21 levels correlated with histological activity index (HAI) in the liver (r = −0.494, P = 0.00002), alanine aminotransferase (ALT) (r = −0.309, P = 0.007), aspartate aminotransferase (r = −0.495, P = 0.000007), bilirubin (r = −0.362, P = 0.002), international normalized ratio (r = −0.338, P = 0.034) and γ-glutamyltransferase (r = −0.244, P = 0.034). Multivariate analysis revealed that ALT and miR-21 serum levels were independently associated with HAI. At a cut-off dCT of 1.96, miR-21 discriminated between minimal and mild-severe necroinflammation (AUC = 0.758) with a sensitivity of 53.3% and a specificity of 95.2%. Conclusions/Significance: The serum miR-21 level is a marker for necroinflammatory activity, but does not differ between patients with HCV and HCV-induced HCC.
- Long-term effects of treatment and response in patients with chronic hepatitis C on quality of life : an international, multicenter, randomized, controlled study (2012)
- Background: Hepatitis C decreases health related quality of life (HRQL) which is further diminished by antiviral therapy. HRQL improves after successful treatment. This trial explores the course of and factors associated with HRQL in patients given individualized or standard treatment based on early treatment response (Ditto-study). Methods: The Short Form (SF)-36 Health Survey was administered at baseline (n = 192) and 24 weeks after the end of therapy (n = 128). Results: At baseline HRQL was influenced by age, participating center, severity of liver disease and income. Exploring the course of HRQL (scores at follow up minus baseline), only the dimension general health increased. In this dimension patients with a relapse or sustained response differed from non-responders. Men and women differed in the dimension bodily pain. Treatment schedule did not influence the course of HRQL. Conclusions: Main determinants of HRQL were severity of liver disease, age, gender, participating center and response to treatment. Our results do not exclude a more profound negative impact of individualized treatment compared to standard, possibly caused by higher doses and extended treatment duration in the individualized group. Antiviral therapy might have a more intense and more prolonged negative impact on females.
- Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers (2012)
- Background: Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly attributable to co-infection with hepatitis B or C. The impact of other risk factors, including prolonged exposure to combined antiretroviral therapy (cART) is poorly understood. Our aim was to determine the prevalence of liver fibrosis and associated risk factors in HIV-infected individuals based on non-invasive fibrosis assessment using transient elastography (TE) and serum biomarkers (Fibrotest [FT]). Methods: In 202 consecutive HIV-infected individuals (159 men; mean age 47 ± 9 years; 35 with hepatitis-C-virus [HCV] co-infection), TE and FT were performed. Repeat TE examinations were conducted 1 and 2 years after study inclusion. Results: Significant liver fibrosis was present in 16% and 29% of patients, respectively, when assessed by TE (≥ 7.1 kPa) and FT (> 0.48). A combination of TE and FT predicted significant fibrosis in 8% of all patients (31% in HIV/HCV co-infected and 3% in HIV mono-infected individuals). Chronic ALT, AST and γ-GT elevation was present in 29%, 20% and 51% of all cART-exposed patients and in 19%, 8% and 45.5% of HIV mono-infected individuals. Overall, factors independently associated with significant fibrosis as assessed by TE (OR, 95% CI) were co-infection with HCV (7.29, 1.95-27.34), chronic AST (6.58, 1.30-33.25) and γ-GT (5.17, 1.56-17.08) elevation and time on dideoxynucleoside therapy (1.01, 1.00-1.02). In 68 HIV mono-infected individuals who had repeat TE examinations, TE values did not differ significantly during a median follow-up time of 24 months (median intra-patient changes at last TE examination relative to baseline: -0.2 kPa, p = 0.20). Conclusions: Chronic elevation of liver enzymes was observed in up to 45.5% of HIV mono-infected patients on cART. However, only a small subset had significant fibrosis as predicted by TE and FT. There was no evidence for fibrosis progression during follow-up TE examinations.
- A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers (2012)
- Background and Aims: Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV infection in Asian populations. Most significant associations were observed for the A alleles of HLA-DPA1 rs3077 and HLA-DPB1 rs9277535, which conferred a decreased risk for HBV infection. We assessed the implications of these variants for HBV infection in Caucasians. Methods: Two HLA-DP gene variants (rs3077 and rs9277535) were analyzed for associations with persistent HBV infection and with different clinical outcomes, i.e., inactive HBsAg carrier status versus progressive chronic HBV (CHB) infection in Caucasian patients (n = 201) and HBsAg negative controls (n = 235). Results: The HLA-DPA1 rs3077 C allele was significantly associated with HBV infection (odds ratio, OR = 5.1, 95% confidence interval, CI: 1.9–13.7; p = 0.00093). However, no significant association was seen for rs3077 with progressive CHB infection versus inactive HBsAg carrier status (OR = 2.7, 95% CI: 0.6–11.1; p = 0.31). In contrast, HLA-DPB1 rs9277535 was not associated with HBV infection in Caucasians (OR = 0.8, 95% CI: 0.4–1.9; p = 1). Conclusions: A highly significant association of HLA-DPA1 rs3077 with HBV infection was observed in Caucasians. However, as a differentiation between different clinical courses of HBV infection was not possible, knowledge of the HLA-DPA1 genotype cannot be translated into personalized anti-HBV therapy approaches.


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United Kingdom
What's the unlikeliest thing you'd expect to come across in sleepy coastal Cumbria? A world-class Grand Prix track, perhaps? A herd of wild rhinoceros? How about the European headquarters of Manjushri Mahayana Buddhism?
The Conishead Priory became just that in 1976 when the New Kadampa Tradition sect took over a 19th century mansion and made it their base. As well as the formidable old buildings and picturesque grounds, squatting beneath the Lake District scenery is a huge Buddhist temple.
Guided tours are available only during the summer, though the grounds and temple are open all year round - check the website for more details, or ask at the World Peace Cafe on Cavendish Street in Ulverston.
Off the A5087 Coast Road
Send your feedback or queries to email@example.com
Search Been there


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Sorry, this job is no longer available
Senior Business Intelligence Manager
NG Digital Marketing
23 October 2012
20 November 2012
Andy Rivers
West London
Contract Type
£50000 - £60000 per annum + package
Further information
Senior Business Intelligence Manager - Leading Games Publisher - West London - £50-60k
My client, one of the leading names in entertainment software publishing worldwide, are looking for a Senior Business Intelligence Manager to join their London office and work across their European region.
The Senior Business Intelligence Manager will help to lead their Business Intelligence team, producing reports and metrics for senior decision makers to help shape current and future strategy throughout their European target markets. The remit of the role crosses both long term and short term company goals, as well as looking at previously untapped areas of opportunity.
A strategic thinker is required for this role, as large data sources need to be able to be transformed into strategic recommendations for the business. From a technical point of view, experience looking at databases with systems such as Oracle, prior modelling experience, and an overall awareness of business and web analytics are key to this role.
The role is based in their West London office, and carries a salary between the £50k and £60k mark, plus package.
NG Digital Marketing
Specialist in Digital Marketing/Media, Market research and Analysis, both temp and perm roles.


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You can view the front page article by going to the homepage, or by going to http://www.dabears.com/content.php?r...draft-Mercilus
You can view the front page article by going to the homepage, or by going to http://www.dabears.com/content.php?r...draft-Mercilus
From the guy running the Chicago Bears:
"There aren't any teams that win year-after-year-after-year."-- Ted Phillips
I believe Ski wants us to know that Kiper thinks the Bears will draft Mercilus. He damn sure posted it enough.
I wouldn't mind the drafting of Mercilis, to be honest with you. He put up the best numbers in college football for a DE last season playing on a bad team. He may not be as big as Quinton Couples, but he also doesn't have the reputation as a loafer like Couples does, either. And besides, it would give Illinois natives great joy that one of their statesmen gets to play for The Beloved.
isn't that why they grabbed Garrette the Wolfe? poor reason. But in this case, I wouldn't mind either.
id rather still have Couples any day of the week, Mercilis had 1 decent year and and good year... not sold on him. Id much rather have two UNC boys on opposite sides of each other
Comparing Garrett Wolfe to Whitney Mercilis is like comparing PBR to Chardenay: one is rot gut, while the other is refined. Mercilis could be a beast, and his stock has improved over the course of the past few weeks. Still, wouldn't it also be nice to see if Coples drops as low as 19th? It's not totally out of the realm of possibility with the way his stock has been dropping.
Don't look now, but look who WalterFootball.com is projecting the Bears to take in the First Round:
Chicago Bears: Quinton Coples, DE, North Carolina
Quinton Coples can easily fall on Draft Day. He's very talented, but there are questions about his work ethic and motor. When asked to evaluate his own effort as a senior in an interview with Charley Casserly, Coples gave himself a C, admitting that he didn't give 100 percent in 2011. I find that very troubling. What's he going to do once he receives a signing bonus?
The Bears may believe he's way too good to pass up, however. They need a pass-rusher across from Julius Peppers, who also happens to be a talented defensive end out of North Carolina. The front office may believe that Peppers could be a great tutor for Coples.
1. Kendall Wright, WR/KR - Just because the Bears acquired Brandon Marshall doesn't mean they'll eschew drafting a receiver at No. 19. Jay Cutler needs a second wideout, especially considering that Johnny Knox is doubtful to play in 2012 coming off back surgery.
2. Jonathan Martin, OT or Cordy Glenn, G - Martin would be an upgrade at left tackle, but Mike Tice is inexplicably infatuated with J'Marcus Webb. Glenn is a great fit for Tice's blocking scheme, and the guard position needs to be upgraded.
Pick change; previously Quinton Coples, DE


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11-06-2012 | #21 | |
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US 4USB ports OFW 3.15 PS Ubuntu
EU 4USB ports CFW 4.21.1 REX There is only one OS; AmigaOS, the rest are just [l]imitations. |
11-06-2012 | #22 |
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beauty is in the eye of the beholder god created all things god loves his creations god is beautiful and he loves beauty If the above statements are taken as true, then would it not stand to reason that god wouldn't see it as an "unclean place"? It is a Natural process, perverted by man not god. Also.... "placement of a quotation or reference to Muhammad in an unclean place is seen as degrading and offensive." Spirits haunting locations are usually considered unclean, do you not reference god in those occasions? Many things in life are looked at 'in one way' when in fact we are guided to look at it in such to see only what a group is seeing. Why not look at the picture & location and take it as 'god brings you beauty even when you believe all is ugly'. For the record I am not religious as groups pervert the meaning of religion. Why do you need a temple when you live in 'gods temple', is he not all around you? |
11-06-2012 | #24 |
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I'd visited the coldboot.net, and you made one or two coldboots about Palestine. I really appreciate it, and I believe you're a wise man and so all to these forum members.
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11-06-2012 | #25 | |
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I understand and agree. the use of any religious icon like that can be very offensive. When it comes to religion and culture, we have to respect (even if we do not agree, or do not make sense based on our own culture). But as stated above, this is not racism. It's xenophobism .
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11-06-2012 | #26 | |
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11-06-2012 | #27 | |
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fix me if I'm wrong, and thanks to you all: @bigo93 @advocatusdiaboli @INFIN1TY @OoZic @Adventfred @Simonbuck @GregoryRasputin @LoboGuara @Ubefuct @stevorkz Last edited by w0313; 11-06-2012 at 07:32 AM. |
11-06-2012 | #28 |
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That thread wasn't racial until that ****** brought racism into it all. People are so dumb these days they don't know if they are racist or a Xenophobe. They just know they hate certain people.
I'm not racist I just don't like most people equally
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11-06-2012 | #29 |
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In the words of the Scottish comedian Frankie Boyle..... "Im not racist, I haven't stopped hating all the white people yet.
11-06-2012 | #30 |
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Hmmm yeah they should have just removed the text.
Same if it was something about Jeebus and the Christians got upset. retarded comments though.. especially the 9/11 one @Simonbuck didnt get offended when I put his name and phone number in a busy mens toilet.. Said they were the busiest and most 'fulfilling' 6 months of his life.. left him feeling 'illuminated'. Hes a good man though and doesnt let his religious views (or George Michael) get in the way of a good time! |
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Look Back, Look Ahead: Fairfax County News to Know
Kits mistaken for kittens, SUV assault, Super Moon and more.
Here's a look at some of the top Patch stories of the past week from across southern Fairfax County and a look at what's coming up:
Those Aren't Kittens…
A Fort Hunt family rescued what they thought were very young kittens from under their backyard shed. When they brought them to a local park on a nice spring day a few weeks later, a park ranger spotted them—and said they weren't kittens. Find out what they were in the story here.
This past week had a lot of police-related news across southern Fairfax County:
Monday, a passenger in a taxi from Prince William County overtook the driver, stole the vehicle and crashed it in Lorton.
On Friday, 21-year-old Shelinda Arrington was killed in what police believe may have been an assault during an argument following a car accident in the Groveton area. Police are looking for the driver of a dark SUV with temporary tags.
Shooting at Target
A woman shot and killed herself inside the Target store in the Burke area Tuesday. If you or someone you know is in crisis, Burke Patch published a list of area resources for those in need.
Missing Girl
A 12-year-old girl was reported missing from the Mount Vernon area on April 27, and police put out a public call for information this week. The girl was found safe with relatives on Friday, and police noted there is a complex set of custodial issues involved in the case.
County Budget, Local Elections
The Fairfax County Board of Supervisors adopted its fiscal year 2013 budget on Tuesday. The budget raises taxes and fees to support funding for human services and other programs. Supervisors Pat Herrity (Springfield) and John Cook (Braddock) voted against the budget, maintaining their opposition from the markup session on April 24.
Also on Tuesday, Vienna, Clifton, Fairfax City and Herndon elected town officials.
Farmers Markets are Open
Farmers Markets throughout the county, including in Kingstowne, Lorton and Mount Vernon, opened.
She Said 'Yes!'
A Lake Braddock High School senior got creative with his prom invitation. Happily, his date said yes.
Super Moon
Did you see the Super Moon Saturday night? There were intermittent clouds in the D.C. metro area, but if you were lucky enough to spot it and take a photo, you can upload photos of the Super Moon here.
Coming Up This Week
Sunday, a man from Fairfax Station will be rappelling down a skyscraper in Chicago to raise funds and awareness for lung diseases. Tom Classick will participate in an event dubbed Skyline Plunge! Chicago, hosted by Respiratory Health Association of Metropolitan Chicago.
You have until Friday to enter the Patch Best Mom in Fairfax County contest. You (or your mother) could win a $50 gift certificate.


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Grey has served Bloemfontein, the Free State, South Africa and the world well over the past 150 years.
Grey has been able to make adjustments and remain relevant in a changing environment in which it has developed, grown and excelled.
The brand is known and revered throughout South Africa and even internationally and the products of the school make a positive difference wherever they are.
Parallel medium education, tolerance, respect for others and loyalty to the school are not only traditions, but firm foundations in a global village.
Grey is structured on these foundations and it is constantly adapting to new developments. The wave of change washing over our country confirms the value of Grey's traditions.


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03/26/13 ¡Basta! Diverse Groups Join Together to Say Enough to Promotion of Sugar Sweetened Beverages read more
03/11/13 Ambassador Raymond L. Telles Dies at Age 97 read more
03/08/13 ¡Vive tu vida! Get Up! Get Moving!® 10-City Tour Announced read more
01/25/13 National Alliance for Hispanic Health Celebrates 40th Anniversary read more
12/17/12 U.S. Senator Daniel Inouye Dies at Age 88 - Nation Loses an American Patriot read more
In a letter sent to President Obama this morning (02/08/2013), the Alliance called on the President to:
The Alliance celebrated its 40th anniversary with a Concert for the Americas at the Kennedy Center for the Performing Arts hosted by five-time Emmy-Award winning journalist Giselle Fernandez. The concert featured internationally renowned mezzo-soprano María José Montiel accompanied by pianist Miquel Estelrich Serralta. The evening also featured presentation of the Alliance's VIDA Awards to Michael J. Astrue, Dr. Regina Benjamin, Dr. Enrique Méndez, Jr., and Dr. Mirta Roses Periago. It was a magical evening of reflection and celebration of 40 years of work together.
The National Alliance for Hispanic Health, 1501 Sixteenth Street, NW, Washington, DC 20036 , tel. 202-387-5000


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24 July 2012
"On behalf of the Commonwealth, I convey our deepest condolences to the family of late President John Atta Mills, and to the Government and people of Ghana" - Kamalesh Sharma
Commonwealth Secretary-General Kamalesh Sharma has expressed his profound sorrow at the passing away of President John Atta Mills of Ghana.
In a statement issued in London, Mr Sharma said: "On behalf of the Commonwealth, I convey our deepest condolences to the family of the late President and to the Government and people of Ghana.
Ghana Minister for Youth and Sports Clement Kofi Humado at the 6th Commonwealth Sports Ministers Meeting speaks on the passing away of President Atta Mills
"President Atta Mills was an inspiring leader of Ghana and a true Commonwealth champion, who will be sorely missed at home and internationally. He was a strong advocate and supporter of the Commonwealth, and our membership benefited enormously from his active participation in Commonwealth life and his wisdom. Ghana, was the first independent nation from Africa to join the modern Commonwealth and made impressive strides under his leadership, in both the fields of democracy and development. I remember with great warmth, my official visit to Ghana in 2009 and the very fruitful interaction that we had.
"The Commonwealth stands in solidarity with Ghana at this time of sadness and bereavement. Our thoughts are with the family of President Atta Mills. May his soul rest in peace."
Richard Uku
Spokesperson/Director of Communications and Public Affairs
Commonwealth Secretariat
Marlborough House, Pall Mall
London SW1Y 5HX
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after playing with the massive genocide machine that is the Rebel titan, and being pleased with its power, i was a little disappointed with the loyalist Titan at first. Individually the loyalist seemed weak and ineffective. That is until i got the point of the loyalist titan. Its not individually all that powerful, but with only a couple levels it makes a supporting fleet untouchable and unstoppable. After reaching lvl 6 i stopped losing ships entirely, while assaulting worlds with mines and fully upgraded starbases. Kudos to stardock, for doing a really good job of making each very valuable in its own unique way...now if you would only release the next beta so i can play with more factions
I wouldn't say the Ankylon needs a few levels to get going, that sounds more like the Ragnarov, Ankylon with Furious Defense and upgraded armour/hull at level 1 is still a nigh-unstoppable beast. Keeping in mind that Furious Defense also boosts it's damage (for some reason.)
For sensiblity's sake I haven't tried soloing the pirate base at level 1 with the Ragnarov yet, I know the Ankylon can and hit level 3 and a half from it.
Edit - Oh yeah, and remember that the Ankylon likes to try and broadside, leaving half of it's weapon banks and it's beams not firing, which is stupid, drive it into the centre of your enemies and watch the fireworks.
The best way to attack with that behemoth is to micro it right into the center of the enemy and watch them all melt away. It is nearly unkillable with a couple levels in it.
You think it unkillable on the attack, stick it in its own Culture and it can hold a system forever. I build a dozen Broadcast towers now before I take on the loyalists or get my head handed to me. The Ragnarok can't seem to touch it if its defending, plus it can sit right between two star bases and let target up-link from the Akkan give them 1/2 the system weapon range. Toss in a bomber fleet or torpedo fleet and they can't even sit back to pound you.
That's the Furious part
Even on it's own the Ank is a monster. The ability to increase its firepower and regeneration as well as damage and suppress the abilities of nearby enemies makes it at home in the thick of the fighting. I love it because usually my enemy will focus fire on my titan, which can endure most of the punishment while the rest of my fleet pummels theirs with impunity.
If anything I think the Rebel Titan needs some tweaks; snipe's damage seems bugged, its been hitting for like 60% of what it says it does. Does anyone know if armor negates damage from Snipe? I can't think of any other reason besides a bug.
The Kol is a brick that the enemy stumbles over. The Ankylon is the wall the enemy slams into and shatters.
[quote who="Mr. Haze" reply="1" id="3111873"]I wouldn't say the Ankylon needs a few levels to get going, that sounds more like the Ragnarov, Ankylon with Furious Defense and upgraded armour/hull at level 1 is still a nigh-unstoppable beast. [/quote]
So far as ive expirimented, one on one the ragnarov can take out the ank at equal lvl through lvl 3 (though this may depend on ability choices) I havent gotten to test beyond that because i havent been able to get a equal lvl one on one fight between the two beyond lvl 3 (usualy cause mine is beyond thier lvl by that point)
if you ever go against AI do you realize in late game the enemys titans are always level 5. even if its 5 minutes after its created.
Titans retain their levels after they're blown up, mastermidge.
oh i've never had mine destroyed so i didnt know that
Shield Mitigation maybe?


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Home » Posts tagged with "Star Park"
Sedona Posse Grounds Joins Star Park Network
Sedona AZ–The City of Sedona Department of Parks and Recreation is pleased to announce that Posse Grounds is a new member of Star Park in the Global Star Park Network. Just as Sedona has designated areas for recreation, sports, and the enjoyment of nature, Posse Grounds Park has been chosen as an area where the starry sky can be enjoyed.
Parks in the Global Star Park Network play an important...


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Brief summary for Clinic Manager-Bismarck Occupational Medicine Clinic
Responsible for overseeing day to day management of the Bismarck Occupational Medicine Clinic to include quality improvement and annual budget. Bachelors degree in healthcare or business preferred and a minimum of two years supervisory experience in a medical setting preferred. Current nursing license preferred. 40 hours/wk


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For "real" scientific literature, underscoring the requirement to eat like the Hunter Gatherer in order to optimize one's health, go to our "Science Links" section. There you will find many links to other Web sites. Of particularly importance are the links to published peer-reviewed reports by Artemis P. Simopoulos, M.D. She in indisputably the world's most respected nutritional authority.
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Comments about REI Campware Cook Pot - 3.2 Liters:
I looked all over for a pot that would be good for long backpacking trips where I would be cooking for at least 3 or 4 people. When I came across this pot I was impressed by how light it was for the size. On my scale it weighs 19.4 ounces with the lid and mesh bag. This is great for a pot that can hold 3.2 liters.
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The bottom of the pot is super grippy with the circular rings and it helped with stability. I didn't have to worry about it sliding off the stove. Heat dissipation was decent, however, I would recommend using this pot with a stove that has a wider flame pattern.
The pot has two handles that can be used to carry it around. If you don't want the handles they can be removed. The lid can be used as a strainer, and it has rubber pads for your thumbs so that you can hold the lid on while tipping it over. Nice feature!
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Overall, I'm very pleased with this pot! I was looking at much more expensive alternatives, but this one turned out to be everything I could want.
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Comments about REI Campware Cook Pot - 3.2 Liters:
I bought this originally when I was putting together my family emergency backpack/kit, but its so good that I have actually ended up using it on a backpacking trip to yosemite. It outperformed my MSR flex 3 in both price, weight/flexibility due to the fact that this can be used as either a frying pan/regular pot.
Also MSR pots seem to have some mysterious nonstick coating that retain food smell and even comes off easily when you rub it with a towel, kind of unnerving to think you may be ingesting that stuff. This pot on the other hand has genuine DuPont classic nonstick coating that works awesome and is highly scratch resistant. Ill be buying another one to add it back to my family emergency kit. Also the MSR deep dish plates fit perfectly in this pot....overall great price for a pot that weights the same as a titanium counterpart.
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A collection of news and information related to Kevin Seraphin published by this site and its partners.
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Antawn Jamison to undergo MRI exam on injured wrist
Antawn Jamison sprained his right wrist in the Lakers' 103-100 loss to the Washington Wizards on Friday. With 1:10 left in the third quarter, Jamison's dunk attempt was blocked by Wizards center Kevin Seraphin. Jamison, who scored 11 points in the game,...Tags: Mike D'Antoni, Washington Wizards, Staples Center, Los Angeles International Airport, Jordan Hill
How will Antawn Jamison's injury affect the Lakers?
Late in the third quarter of the Lakers' loss to the Washington Wizards (103-100) on Friday, Antawn Jamison was injured when his shot was blocked by Kevin Seraphin. The Lakers forward left the game with his team up by seven but would not return. X-...Tags: Washington Wizards, Golden State Warriors, Staples Center, Utah Jazz, Sprained Wrist
Preview: Lakers vs. Washington Wizards
The Lakers (36-33) host the Washington Wizards (24-43) on Friday night at Staples Center. Kobe Bryant (ankle) and Pau Gasol (foot) are both expected to return from injury against the Wizards. Coach Mike D'Antoni said he intends to return Gasol to the...Tags: A.J. Price, Washington Wizards, Pau Gasol, Staples Center, Basketball
At trade deadline for Wizards, who goes?
The Washington PostLong after what might have been his last — or second-to-last — practice as a member of the Washington Wizards, Jordan Crawford hardly looked like a man worried about his future or prepared to distance himself from his teammates. Engaged in a...Tags: Atlanta Hawks, Toronto Raptors, Brendan Haywood, James Harden, Randy Wittman
Wizards defeat Hawks, 93-83, in Wall's return
The Washington PostAs John Wall ripped off his warm-ups and went from the Washington Wizards' bench to the scorers' table, a roar filled the Verizon Center. Wall received a standing ovation as he stepped onto the court for the first time this season — the first time...Tags: Randy Wittman, Larry Drew, A.J. Price, Atlanta Hawks, Washington Wizards
Digest: Terps wrestler Sheptock earns ACC weekly honors
Colleges Terps wrestler Sheptock earns ACC weekly honors Maryland junior Jimmy Sheptock earned Atlantic Coast Conference co-Wrestler of the Week honors after posting a 4-1 record and placing second at the Nittany Lion Open, the conference announced...Tags: Loyola Greyhounds, National Basketball Association, Washington Wizards, Maryland Terrapins, Education
Wizards' 12th loss in row, 118-92, is their worst this season
Trail Blazers @Wizards Wednesday, 7p.m. TV: Comcast SportsNet Only a few seats down from the Washington Wizards' bench, owner Ted Leonsis sat courtside with Nationals owner Mark Lerner as his team hosted the San Antonio Spurs at Verizon Center....Tags: Comcast SportsNet (tv network), National Basketball Association, Tim Duncan, A.J. Price, Washington Wizards
Wizards' Wall can only wait to return to lineup
Shirtless, John Wall crouched and dribbled a basketball above his head with his right hand and another low to the ground with his left hand. Unable to keep the routine together as he reached half-court, Wall grunted as he lost control, started over, and...Tags: Injuries and Wounds, Blake Griffin, Washington Wizards, Feet, Physical Fitness and Exercise
Practice? Miller living familiar Heat script
"Practice? We're talking about practice, man. We're talking about practice. We're talking about practice?" With apologies to Allen Iverson, yes, we're talking about practice. And in the case of Miami Heat forward Mike Miller, we're talking...Tags: Ray Allen, National Basketball Association, Dan Majerle, NBA Draft, Radio
Irving's 29 leads Cavaliers over Wizards
Kyrie Irving scored 29 points, Anderson Varejao had a career-high 23 rebounds and the Cleveland Cavaliers opened the season with a 94-84 victory over the short-handed Washington Wizards on Tuesday night in the first game on the NBA schedule. Rookie...Tags: National Basketball Association, Washington Wizards, Basketball, Emeka Okafor, Anderson Varejao
Thibodeau contract talks stalled
With the draft completed, the Bulls will shift their focus to the next big issues on their docket. Free agency opens Sunday. And while Tom Thibodeau's contract extension talks have been ongoing for awhile, significant work remains, according to sources...Tags: National Basketball Association, Jerry Reinsdorf, Trenton Hassell, Gar Forman, Washington Wizards
Granger pushes Pacers past Wizards
Sports NetworkDanny Granger poured in 20 points and the Indiana Pacers beat the Washington Wizards for the third time in three weeks with a 109-96 victory on Wednesday. Darren Collison scored 17 points and dished out 11 assists while Leandro Barbosa and Tyler...Tags: Washington Wizards, Jordan Crawford, Danny Granger, Darren Collison, Leandro Barbosa
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