In this paper, we proposed a method for locating, identifying, and admitting the activities of intrigued, in nearly actual time, from outlines gotten by a ceaseless tide of video information from an observation camera. This article endorses the way to follow, distinguish, and take note of the exercises of captivated in about real-time from follows gotten by a nonstop stream of video information from a reconnaissance camera. The appearance takes input, follows an appeared time space and can provide an activity title based on a single format. We illustrate that YOLO is a viable strategy and comparatively quick for localization within the custom dataset. The findings and analysis of the model will be presented in the following sections. The demonstration collects input outlines after a foreordained interim and can dole out an activity name based on a single outline. We anticipated the activity name for the video stream by combining the discoveries over a period. Because of its benefits, this YOLO strategy is utilized to distinguish action. This method may be used in various settings to tackle real-world problems, such as shopping malls, ATMs, banks, offices, homes, and societies. We have developed a model that detects some ideal human actions.


Rises in the National Health Service pension age sponsor the assumption that health professionals will retire later. Labour Force Survey evidence indicates that if current patterns of early exit persist in context of a relatively high and rising average age there is prospect of significant labour shortages within a decade.


We present a unified method to estimate current–voltage characteristics of insulators starting from ab initio electronic calculations of the properties of the dielectric material. The method consists of three stages: (1) computation of trap energy distributions for excess electrons by means of density functional theory, (2) computation of local electron mobilities from a multiple trapping electron transport model which includes trap filling effects and (3) macroscopic integration of the Poisson and current–field equations, using local electron mobility data from stage (2) to predict the current–voltage characteristics for a material of a given width. The only input to this procedure is the chemical composition of the insulating material. We compare our model results with experimental studies of the current–voltage curve of cross-linked polyethylene.


The article deals with the complex research of compound adjectives used to describe a person's character and combined into an appropriate lexical microsystem. The special attention is given to the definition of the term "compound word". Composites are analyzed at phonetical, semantic, morphological and orthographical levels. Dominating words within the researched microsystem are considered as those with the main stress on the second component, which is the semantic centre in the structure of a compound lexical unit. The most common word-building patterns (adjective + noun with the ending -ed, adverb + noun with the ending -ed or Participle II) are studied. A specific group made up of composites with such components as -tempered, -minded, -self and -headed has been analyzed. The variants in writing (as one word or with a hyphen) are considered as well. Compound adjectives used to describe a person's character may consist of two simple or two derived stems and also have one component with a derived stem expressed by Participle I, Participle II or noun with the ending -ed in their structure. The researched composites are classified into lexical sets and semantic groups. Complex lexical constructions that belong to the microsystem "person's character" can be endocentric and exocentric by their semantics.


A higher order zig-zag shell theory based on general tensor formulation is developed to refine the predictions of the mechanical, thermal, and electric behaviors. All the complicated curvatures of surface including twisting curvatures can be described in a geometrically exact manner in the present shell theory because the present theory is based on geometrically exact surface representation. The in-surface displacement fields are constructed by superimposing linear zig-zag field to the smooth globally cubic varying field through the thickness. Smooth parabolic distribution through the thickness is assumed in the out-of-plane displacement in order to consider transverse normal deformation and stress.


The invention relates to a battery-powered electric power tool (1) for operation with at least two battery packs (2a, 2b) comprising at least two battery pack interface (3.1, 3.2) adapted for mechanical and electrical receiving a respective battery packs (2a, 2b), each of said is formed battery pack interface (3.1, 3.2) to the battery pack (2a, 2b) of different structure, in particular battery pack (2a, 2b) with different nominal voltages receiving, a control unit (9), arranged to detect a nominal voltage of each (in the battery pack interface 3.1, 3.2) captured battery pack (2a, 2b), and for generating at least one electrical control signal (y) based on the detected rated voltages, and switching means (10) adapted to receive the at least one electrical control signal (y) of the control unit (9), and for controlling at least one controlled switch (S1, S2, S3) on the basis of the at least one control signal (y) to zumindes t electrically connecting an electrode terminal (A1, K1) of a first battery pack interface (3.1) with an electrode terminal (A2, K2) of a second battery pack interface (3.2).


The paper is divided into three parts. The first part, regarding the preliminary aspects, contain an overview of the commercial and non-commercial professionals, in the New Civil Code provisions. The second part defines the concept of professional and the concept of enterprise as a systemic organized activity and also the distinction between the commercial and non-commercial person, as the laws in force provide. The third part exclusively treats the commercial professionals.


Elgar's Earnings. By John Drysdale. Woodbridge [UK]: The Boydell Press, 2013. xii + 241 pp. ISBN 978-184383-741-1; $90 John Drysdale's recent study Elgar's Earnings stands out for its innovative approach to the composer's career. By shifting the focus on Elgar from the substance of his music to the composer's financial standing, this book offers unique perspectives on the composer's fiscal status through publications, royalties, concert fees, and other, related income. John Drysdale's stated purpose of exploring "Elgar's constant dissatisfaction with his financial position by unraveling the facts about his earnings" (p. 7) results in a study that draws on economic factors in Victorian and Edwardian England. This emphasis takes readers from musical studies to financial ones, as the typical exploration of manuscripts, prints, and related publications gives way to economic documentation, with payment books, royalty statements, hire fees, and even wills in addressing questions about Elgar's income through his compositions. The organization of this study warrants attention for its presentation of resources that could be used in studies of other composers of the time, with chapters devoted to "Opportunities for British Composers" (pp. 9-27) and an overview of the artistic scene in "Authors, Painters and Composers" (pp. 28-55), as well as sections on the influence of Novello on music publishing: "Novello and the Music Publishing Business" (pp. 56-79); "Novello, Royalties and Copyrights to 1914 and the 1904 Royalty Agreement"(pp, 80-108); and "Novello, Royalties and Copyrights 1914 to 1934 and other Music Publishers" (pp. 109-27). Those interested in the role of Novello in British music in the nineteenth and early twentieth centuries should return to Victoria Cooper's exemplary work on the publishing house. At the core of this study is the chapter on "Royalties and Copyrights on Elgar's Major Works" (pp. 110-51) in which Drysdale offers a glimpse at the revenue the composer earned from his "major" works. That stated, the major works that audiences of the twenty-first century associate with Elgar are not necessarily the ones that captured the public of the composer's day. As much as modern audiences are familiar with The Dream of Gerontius through recent performances and recordings, other vocal works, like The Apostles and The Kingdom do not have the same associations with the composer as the more popular Enigma Variations or, for that matter, the perennially familiar Pomp and Circumstance march, no. 1 and its vocal arrangement as Land of Hope and Glory. Nevertheless, the accounts of the financial arrangements for important works like Elgar's Enigma Variations are sobering, and bear further consideration as part of the composer's reception. While Drysdale often deals with the funds Elgar received for his rights, it would be useful to explore the accounts further to determine the revenue the publishers received from administering those rights, along with some idea of the expenditures the firms made on behalf of the composers under contract. This would help to establish a larger context for the ways in which Novello, Boosey & Hawkes, and other publishers treated composers of the time. Statistical documentation for the volume is published online and available free of charge at http://www.boydellandbrewer. …


Packet scheduling under arrivals and deadline constraints is an important model for analyzing the QoS tradeoff between delay and energy efficiency. It is well known that a tazy offline scheduling scheme which minimizes the peak transmit power across the transmission duration, consumes the least energy in meeting a common deadline constraint for the arriving packets, over a point to point wireless Gaussian channel. In this scheduling framework, we study the impact of an additional adversarial node called the jammer, which relies on dynamic energy harvesting sources to power its hardware. The jammer's objective is to increase the energy expenditure at the legitimate transmitter, by injecting adversarial noise at the receiver. An interesting min-max game now follows, with the transmitter minimizing its own energy consumption based on the jamming strategy. We derive the optimal scheduling actions for the transmitter and the jammer in the offline setting.


The purpose of this article is t o briefly review the relationship between the inhibition of the renal Na+ + K+-ATPase system and the excretion of Na+, and t o present our new work on this subject. The inhibitors considered will be only cardiac glycosides, ethacrynic acid, and mercurials since the renal work with other inhibitors of the enzyme is too fragmentary for coherent analysis. The emphasis, although not t o the exclusion of other approaches, will be on in viuo experiments since most other renal preparations lack the dynamic qualities of filtration, reabsorption, and readjustment t o intervention. Since the discovery of the Na+ + K+-ATPase by Skou' the enzyme system with a very high activity has been found in the kidneys of all mammalian and avian species so far examined. The properties of the renal Na+ + K+-ATPase system resemble so closely those of transport ATPase in the human erythrocyte as to suggest that the basic mechanism for active translocation of Na+ and K+ is the same in the two t i s s ~ e s . ~ ~ The kidneys of dog, cat, rabbit, chicken,6 and appear from in vitro measurements t o contain sufficient Na+ + K+-ATPase activity t o theoretically account for the reabsorption of the entire filtered load of Na'. On the other hand, in the rat, and possibly in other species, the lowest enzyme activity is located in the proximal tubule, where most of the filtrate is reabsorbed, and the highest activity is in the distal nephron, including the ascendinglimb of Henle's l o ~ p , ~ ~ ' ~ a site of an ion pump responsible for the hypertonic environment in the medulla and consequently the production of hypertonic urine. In the proximal tubule the enzyme is limited t o peritubular border," where according t o electrical measurements the active reabsorption of Na+ occurs.1zi13 Accordingly, the outer medulla of d0g,I4-l6 cat,l4>l7 rabbit,'4i18919 rat, guinea pig, squirrel monkey, partridge,I4 and which contains the thick ascending portions of the loops of Henle, and is by weight a relatively small portion of the kidney, has a higher enzyme activity than does the cortex, which contains a mixture of proximal and distal nephrons. Papilla has a minor role in Na' reabsorption and has a low enzyme activity in d0g,6*14>15 and man.' It appears that cortical and medullary Na' + K+-ATPase is similar. Under standard conditions the K,'s for MgATP and Na' are identical within species for enzyme preparations from both tissues of dog and rat kidneys.14 Binding of ouabain per unit of enzyme is similar for cortex and medulla of dog and guinea pig.14 The Is0 for ouabain is the same (1.6 X 10-6M) for microsomes of dog medulla,16 cortex," and whole kidney homogenate,I6 with 20 mM K", 100 mM Na', and 3 mM MgATP present. The value for both tissues of man is 2.3 X 10-6M.2z Under the conditions of the same laboratory the cation requirements for the enzyme activity are similar in cortical microsomes from canine and human kidneys. In the dog the K, for K+ is 0.8 mM in the presence of 100 mM Na'. The K, for Na' is 5.7 mM in the presence of 20 mM K'. The respective values for


The Z transform is typically used in digital filtering and signal processing problems. The paper illustrates the use of the Z transform in implementing the FDTD method where it is useful to avoid dealing with convolution integral in the time domain by going immediately to Z domain. This work study the pulse propagation in free space that comes upon a plasma. Plasma is very interesting medium and the results illustrated that at low frequencies, it looks like a metal, and higher frequency, it become transparent just like a dielectric medium.


Tools that extract metrics from object oriented code are widely used as part of static code analysis which acts as a feedback mechanism for the managers, developers and other stake holders to improve the software quality. The software industry and academic research have confirmed the necessity of such tools and the impact they have on ensuring quality software. There is a transition of tools from measuring traditional software metrics to object oriented metrics as the focus has shifted to object oriented design and development. This paper presents a systematic review of both commercial and open source object oriented metric tools, highlighting the features supported and extensibility. The results are useful to arrive at the most suitable tool depending on the requirements of the stake holder. The results also identify a potential for an object oriented tool that can address the need for a tool that can work effectively across many object oriented languages and also be flexible for extending it to different languages and metrics.


The ECB has the ultimate responsibility for the single monetary policy. The ECB's goal is maintaining price stability over the medium term; this means ensuring inflation stays in the region of 2 percent. If some EMU members are more favoured by the ECB's interest rate decisions then this would cause implicit problems and overall, the monetary union would face problems regarding structural divergences between member countries. These divergent problems would make each country differ from each other with regard to inflation and GDP growth. Thus the ECB has the difficult task of deciding a single interest rate that fits all member countries. Calculations based on interest rates versus forecasts on output gaps and inflation do illustrate a pattern that shows that some countries are more favoured by interest rate decisions than others. This poses a crucial question as to whether all countries benefit from membership in the monetary union and, by extrapolation, does the ECB as an institution have enough power to execute pivotal monetary politics?


In 1994 a 44-yr-old male was admitted for surgical resection of a hard, not painful, nodule which was believed to originate from the isthmus of the thyroid gland. He was known to have mild asthma, treated with inhaled corticosteroids and short-acting β2-agonists. His medical record revealed a smoking history of 20 pack-yrs. The patient denied any other symptoms, except the presence of the nodule.

On physical examination a hard nodule was felt anteriorly to the trachea. A clear separation with the thyroid gland could not be made.

A preoperative computed tomography (CT) scan of the neck revealed a calcified nodule on the midline, adjacent to the trachea (fig. 1⇓). Laboratory studies demonstrated a euthyroid status.

Fig. 1.—
Chest computed tomography scan. Internal scale bar=5 cm.

During surgery, the nodule could not be separated from the tracheal cartilaginous ring and a left hemithyroidectomy, with resection of part of the affected cartilaginous ring, was carried out (histology of the nodule in fig. 2a⇓). The tracheal defect was closed with a muscle flap. The patient continued to do well on follow-up examinations ≤5 yrs postoperatively, without complaints. …


Scientific concept of development,at the height of the times,summarized profoundly the issues of development at home and abroad.It analyzed scientifically China's development in the course of facing the new situations and new problems,further answered the question of why, how,what major issues such as development,enriched the development of human society's understanding,deepened the understanding of the laws of socialist construction,the sublimation of the understanding of the laws of the ruling party.The scientific concept of development proposed and indicated that our party's idea of sublimation.


A cracked 7Cr17MoV steel kitchen knife was analyzed by macroscopic inspection, hardness testing, chemical constituent test, metallographic inspection, scanning electron microscopy and energy spectrum analysis. The results showed that the cracking mode of the kitchen knives were stress corrosion; there were more large angular block carbides and uneven distribution of carbides in the kitchen knife material, causing stress concentration and initiation of microcracks, resulting in instability of the passivation film on the stainless steel surface. When the kitchen knives produced and processed in a chlorine-rich environment, chloride irons were preferentially corroded at the weakened passivation film to form corrosion pits. The bottom of the corrosion pit was microcracked due to stress concentration, and the chloride irons continued to corrode along the channels formed by the micro-cracks, which further expanded the microcracks. During the grinding process, the micro-cracks expanded outward under the action of external forces, resulting in cracking.


Early diagnosis of hypertension in vast masses and control of tension constitutes a major part of the public health studies. The aim of this study is to identify the impact of information and healthcare services provided during the home visits on the effectiveness of developing life quality and bringing in life behaviour related to health. The design of the study was single -grouped pre-test and post-test. Forty-eight individuals of 65 years of age or older who have had hypertension diagnosis for at least six months were involved in the study. A nursing initiative encompassing training-healthcare services was carried out from the first week. Patients were provided with seven-week-of training in total with 2-week intervals. Data were obtained by means of a questionnaire, blood pressure, Body Mass Index (BMI) measuring and Health Promotion Life-style Profile (HPLP)Data were analyzed by using SPSS. At the end of study, a statistically significant decrease was observed in blood pressures and BMI values while a statistically significant increase was observed in nutrition, health responsibility and stress management behaviours.


Japanese agricultural studies in Africa began in the 1960's when most of the African countries became independent. However in only forty years these studies have accumulated many field research papers and acquired considerable importance in Japanese agricultural studies. By the World Bank in 1980's the structural adjustment policies introduced in Africa and the political and economic situation of Africa have changed dramatically. African societies were transformed drastically. In the 1990's, Japanese agricultural studies in Africa also changed to focus on the study of the relationship between village level studies and world wide economy. Another two aspects were added in the 1990's, namely the multi-disciplinary studies of African agriculture and studies of the relationship between agriculture and human society. The author points out three important issues in the future of Japanese agricultural studies in Africa. The first one is that Japanese agricultural studies have a responsibility to contribute to the feeding of Africa and the improvement in African agricultural studies. Th second one is that agricultural studies in Africa contribute to the rethinking of Japanese agricultural studies from the viewpoint of the relationship between humans and their environment. For example recent studies have focused on small holder agriculture, the meaning of modern technology, and new ways of thinking about productivity. The final one is that the study of global views of food production based on the insights gained by long term field work at the village level which will be needed in the future.


Medical negligence or medical malpractice is as old as the medical practice itself. In the UK, both concepts have evolved and transformed over the years. Medical negligence litigation process in the UK is as clear as the English law itself and its accompanying procedural rules.

Conversely, the Saudi laws governing medical negligence is quite novel and unique as it is
governed by the Shariah law. Its litigation process for medical negligence are also quite in contrast to that of the English system. This dissertation made a comparative studies of the concept and system of litigation for medical negligence in these two distinct legal systems.

The study espouses a novel perspective to the
conventional precepts on medical practice and medical negligence litigation process.


In a wireless LAN quality of service (QoS) is limited by hidden nodes, coverage and delay spread. The channel access mechanism of HIPERLAN Type 1 will provide a minimum collision rate in addition to a fair sharing of resources among all nodes. The author investigated the influence of the packet length, number of nodes and lifetime on the expected user data rate. The results show that a HIPERLAN Type 1 system is very robust under heavy load conditions. Earliest data first (EDF)-scheduling of data packets enables tuning of multimedia performance by adding an optional buffer to the HIPERLAN user data interface.


THE BLACK-WHITE ACHIEVEMENT GAP THROUGH THE LENS OF CENTRAL OFFICE ADMINISTRATORS Roger S. Baskin, Ph.D. George Mason University, 2013 Dissertation Director: Dr. Robert G. Smith This study investigated the perceptions of Black and White central office administrators regarding the Black-White achievement gap. Four research questions (RQ) were explored: RQ1: How docentral office administrators understand the causes of the BlackWhite achievement gap? RQ2: How do central office administrators perceive their role in impacting the Black-White achievement gap? RQ3: How docentral office administrators address Black-White achievement gaps in their districts? RQ4: How do perceptions about achievement gaps and agency vary between Black and White central office administrators? Data for this qualitative study were gathered in 15 interviews with current and former central office administrators from seven districts in the Middle Atlantic region. Eight of those interviewed were White and seven were Black. Relationships between teachers and students were viewed as a major factor in the creation of achievement gaps. Raising the issue of gaps and providing professional development to educators are two major ways central office administrators viewed their role. Teachers and their inability to develop positive relationships with students were identified by participants in the study as a major obstacle in closing achievement gaps. Administrators used a multifaceted approach to addressing achievement gaps including working directly with students, parents, educators (through professional development), and changing the structure of the school day to provide intervention. A major distinction between Black and White administrators in the study had to do with the perceived obstacle of alienation. Five of the seven Black administrators expressed some sense of alienation due either to job title (typically those who work in offices of diversity or equity) or race.


The algorithm proposed here can be used in 2D two\|step plane and axisymmetric Eulerian hydrodynamic method to deal with the interface of a mixed cell. It takes advantage of the idea of Youngs method: in a mixed cell, the interface is regarded as a straight line. The area fraction of eight cells surrounding the mixed cell is used to determine the normal orientation of the interface, the area fraction or the volume fraction of the mixed cell is used to determine the equation (position) of the interface, and then the flux passing across the boundary of the cell according to this interface and the area fraction or the volume fraction of the cell at next time is calculated. In the last part of this report, some numerical results are presented, which include the precision tests of interface calculation, the comparison with SLIC and the calculations of comprehensive problems.


Feeding in emergencies has been based on anthropometric measurements that mostly depend on weight measures and tend to focus on short-term weight gain as its goal. One of the new trends in emergency feeding is to provide feeding therapy at the community where patients are rather than keeping them as inpatients. A community-based feeding program has made the feeding program more sustainable, which is particularly important in the era of protracted emergencies and civil war. Little is known, however, about the impact of nutritional support on long-term neurocognitive development in chronic emergencies. KinderBerg International, eV, has implemented a long-term supplementary feeding program for 6 months after children were discharged from our feeding center. After establishing mother–child bonding before discharge, the children were followed-up for 6 months through monthly visits with anthropometric measurements and neurocognitive assessments. We report our initial findings, which indicate that there are sign...


In the 20-year journey of the American College of Medical Genetics, public health has had an important influence on the emergence and progress of genomic medicine. This influence can be readily discerned on the pages of Genetics in Medicine, the official journal of the College. As the journal's section editor in public health, I write this special anniversary commentary on the heels of the fourth national conference on genomics and public health, held in Bethesda, MD, in December 2010.1 The conference was attended by more than 500 people from multiple sectors including academia, industry, state and federal government, consumers, and the media, all interested in the translation of genome-based discoveries into health benefits now and in the future. The conference represented more than a decade-long progress in establishing the field of public health genomics as a scientific foundation for using genetic information to improve the health of populations. In a time of economic downturn and shrinkage of public health at the federal, state, and local levels, more resources will be shifted toward emergency programs and services with immediate health impact. Therefore, investments in public health genomics in 2011 are at an all-time low. This may be attributed, in part, to the fact that the promise of genomic medicine is still largely unfulfilled, and as such, genomics has not demanded the urgency of public health action today. Yet, if the promise of genomics is to be realized in the next decade, public health will have to play, as it has done in the past decade, an important leadership role. In this commentary, I revisit the basics of public health genomics and how the field has been represented in Genetics in Medicine. I use the three essential public health functions and priorities in genomics as discussed elsewhere2: (1) policy development function and public health's unique "honest broker" role, (2) assurance function and public health's role in implementation and evaluation of services, and (3) assessment function and the role of multidisciplinary population sciences in assessing impact and value of genomic information in health and health practice. Public health genomics in 2011 is more important than ever in realizing the health benefits of human genome discoveries in the 21st century.


Guillain-Barn! syndrome is a subacute inflammatory demyelinating polyradicular neuropathy of the peripheral nerves. It is characterized by varying degrees of weakness, sensory abnormalities, and autonomic dysfunction. The cause of Guillain-Barre syndrome is not completely understood, but it is believed to be a postinfectious autoimmune disorder, because approximately two thirds of all cases are preceded by an infection, such as those caused by human immunodeficiency virus, cytomegalovirus, Epstein-Barr virus, and Campylobacter jejuni. Occasionally Guillain -Barre syndrome has been reported to come after vaccinations of various types. C jejuni infection, thought to be the most common antecedent infection to Guillain-Barre syndrome and the only bacterial infection that regularly precedes it, has been implicated in 50 to 75 percent of all cases. Culture studies have proved that a high proportion of patients with Guillain-Barre syndrome have C jejuni infection in their stools at the time of the onset of neurologic symptoms as well. We describe a case of Guillain-Barre syndrome associated with gastrointestinal C jejuni infection. This case not only highlights the clinical aspects of Guillain-Barre syndrome but also illustrates the severity of this neurologic syndrome and the lack of response to both plasmapheresis and immunoglobulin therapy.


Gilles de la Tourette syndrome otherwise simply known as Tourette Syndrome (TS) is characterized by involuntary movements and phonation; invariably classified as tic disorder1.A tic is an involuntary, sudden, rapid, recurrent, non-rhythmic, stereotyped, motor movement or vocalization. The most common co-occurring disorders with TS are Attention Deficit Hyperkinetic Disorder (ADHD) 50-60% and Obsessive Compulsive Disorder (OCD) 30-70%. This Case report describes the history of a 38-year-old man who showed symptoms of tic disorder, was initially misdiagnosed as having psychosis that later proved to be Tourette Syndrome. The patient was presented to the Psychiatry department in the October 2013 with chief complaints of repetitive turning of face to the left, anger outbursts, involuntary raising of the upper limbs, foul words usage and occasionally counting fingers over the past year that intensified in the 15 days prior to admission. The patient was prescribed a typical anti-psychotic such as Risperidone 2mg twice a day. Consequent admissions over the next one year showed new symptoms such as irritability, sudden movements of both upper and lower limbs, which progressed to jerking, hitting of his forehead multiple times, generalized body weakness, tremors of limbs that invariably led to disturbed sleep patterns. He was given combinations of neuroleptics such as Haloperidol and Olanzapine at doses of 5mg respectively with anti-depressants such as Lorazepam 1mg once daily and Fluoxetine 2omg thrice daily along with an anti-muscaranic agent Trihexyphenidyl 2mg twice daily. The patient was non-compliant with the prescribed medications. The patient reported in June 2015 and was admitted for a period of one month with extra pyramidal symptoms (EPS) as a side effect of the anti Haloperidol. The doctors decreased the dose of Haloperidol to 2.5 mg once daily to minimize his symptoms. Although the tic symptoms decreased effectively during his hospital stay, there were clear abnormalities in his social interaction which the doctors diagnosed later as schizoid personality traits.


Introduction: Craniosynostosis are cranial deformities resulting from the early closure of one or more sutures. Concomitant facial changes usually result from the involvement of multiple sutures, which may lead to restriction of cranial growth and brain expansion, ocular compression, and breathing difficulties. The distraction osteogenesis (DO)for frontofacial or posterior advancement have increased the safety of the procedure. The aim of this study was a critical evaluation of the use of DO in the surgical treatment of syndromic craniosynostoses, based on the experience of a single craniofacial team.
Methods: Retrospective review of third six patients operated from 2003 to 2022 by the same craniofacial team.
Results: 19  boys and 17 girls were operated, all with rigid distractors. Twenty-nine of them underwent monobloc frontofacial advancement.  In seven patient a Le-Fort III/subcranial advancement was performed. A posterior craniofacial advancement was performed in 5. In 11 a fronto-orbital advancement was done in the first year of life. The mean age was 6.0 years (range, 6 months to 13 years). All patients presented with some degree of exorbitism,  upper airway obstruction and signs of intracranial hypertension. Cerebrospinal fluid leakage was the most frequent complication (9 cases), pterygomaxillary disjunction was revised in 8, lateral rim orbital fracture in 3 cases, and 3 complication related to the device.
Conclusions: The evolution of surgical techniques allowed DO with rigid distractors to be an important tool for treating the craniofacial issues related to syndromic craniosynostoses. The multidisciplinary team's learning curve is critical to reducing complications associated with osteogenic distraction.


Different types of biopsies During a biopsy, fine needles are inserted into the prostate gland. These needles remove small amounts of tissue for pathologists to analyse. Some biopsies spread the needles out over the entire gland. These are called systematic biopsies. The needles go into random parts of the prostate, trying to cover all regions of the gland. Depending on the size of the prostate, this could mean 10 samples, or even up to 50.


The push for an efficient biofuel is at an all time high all around the world. Lately, a consideration for an algal biofuel has made algae a prime candidate for research. However, the most efficient way to obtain a known culture is to receive it form a culture collection. Or is it? Our research has shown that the genus Chlorella has some issues according to the DNA of the organisms compared to the taxonomy of the culture collections. To show the differences of what the cultures are compared what they are said to be, the pure culture was isolated, its DNA was extracted, PCR amplified, and sent to sequencing. Using the MEGA 5 program in association with the (Internal Transcribed Spacer) ITS2 database, the sequence is annotated. Each element (18S, ITS1, 5.8S, and ITS2) at this point is individually aligned. The elements are then concatenated, and a maximum likelihood tree is run on the MEGA 5 program. This produces a tree that species in the Chlorella genus will group together in an obvious way with acceptable bootstrap values. With this tree, it will be obvious which strains belong to a given species, and which do not. The source of support for this project comes from NSF 25‐6230‐0130‐009


This article explores the dynamics of freedom and conformity in religious dress prescriptions and fashion, arguing that although fashion is popularly perceived as liberating and religion as constraining when it comes to dress, in reality both demand conformity to normative expectations while allowing some freedom of interpretation. The article goes on to trace the emergence of new forms of fashionable religious dress such as the human-hair wigs worn by some orthodox Jewish women and the new forms of Islamic sportswear adopted by some Muslim women. It shows how these fashions have emerged through the efforts of religiously observant women to subscribe simultaneously to the expectations of fashion and religious prescription, which are seen to operate in a relationship of creative friction. In doing so, they invent new ways of dressing that push the boundaries of religious and fashion norms even as they seek to conform to them.


Using nicotine silicotungstate as active material, a PVC membrane nicotine ion selective electrode was prepared. The electrode shows near Nernstian response over the concentration range of 8.0×10 -5 ~1.0×10 -1 mol/L nicotine in solutions of pH 5~7 at 25℃. The standard electrode potentials were determined at different temperatures and used to calculate the isothermal coefficient of the electrode . The influence of pH on the electrode response to different concentrations of nicotine was shown in pH mV profile. The profile was used to calculate the dissociation constants of nicotine in aqueous solutions. The average values for the pKa 1 and pKa 2 of nicotine solution measured by this method were found and compared with the literature values of 3.04 and 7.84.


This thesis submitted for the partial fulfillment of the requirements for the degree of Master of Philosophy in Department of Language Education, Institute of Education and Research, University of Dhaka, Bangladesh.


The present paper focuses on wind turbine rotor modeling for loads and wake flow prediction. Two steady-state models based on the actuator disk approach are considered, using either a uniform thrust or a blade element momentum calculation of the wind turbine loads. A third model is based on the unsteady-state actuator line approach. Predictions are compared with measurements in wind tunnel experiments and in atmospheric environment and the capabilities and weaknesses of the different models are addressed.


In 2017, Australia played host to "the world's most ridiculous constitutional crisis". Section 44 of the Australian Constitution, which had been invoked in only a handful of cases to find candidates ineligible to be chosen to sit in the Commonwealth Parliament, was suddenly at the forefront of national attention. So was the High Court, sitting as the Court of Disputed Returns, which by the end of 2017 had ruled that eight of the 10 individuals it had examined were ineligible to have been elected at the 2016 election.


The invention relates to a translucent building walling public and residential buildings, mainly for glazing balconies and stairs and can be used in the manufacture of windows, glass windows, filling apertures of buildings and other architectural structures. The object of the utility model is to overcome the shortcomings of the factory modules consisting of aluminum profiles and the creation of such a module for the protection of translucent building structures, which is economical to manufacture and of reducing the complexity of installation on site. Technical result is achieved due to the fact that in the known plant translucent module for glazing building structures, preferably balconies and loggia comprising frame structure made of a metal side profile racks connected thereto the lower and upper profile mullion filled with transparent and / or opaque sheet material secured by resilient sealing bead and, with grooves in the profiles of the side struts and mullion placed seal of an elastic material, the profile cat ryh corresponds to the profile of the corresponding slot, static amplifier coupled to the side wall of the module and the upper part of the module is provided with a mounting unit, changes, namely, a static amplifier is configured as a metal insert, with the possibility its placement in the slots the inner and / or outer profile side module racks, and a static amplifier is provided with bores for fixing it in the groove profile side post and joining it with the side of the bar adjacent module. The advantage of the proposed technical solutions known before is that a new design of a static amplifier and its placement in the chambers formed by the profile of internal and external portions of the side pillars and mullions, increases reliability of the module under wind loads, and facilitates installation of the module in the facility, as It does not require special fasteners for attaching the static amplifier in the prior art and increases the usable area of the balcony or loggia. 4 ZP f ly-3-yl.


Recently, numerous studies have indicated that melatonin, the hormone of pineal gland, affects the processes of differentiation of many cells, including preadipocytes into brown, beige and white adipocytes. Therefore, it is important to study the possibilities of using melatonin as a factor for the differentiation of preadipocytes to control the adipose tissue functional activity in the treatment of various diseases, including obesity. THE AIM of the study was to evaluate the morphology and functional status of brown adipose tissue at the different time of melatonin administration. MATERIALS AND METHODS. Outbred rats were divided into 3 experimental groups: control, administration of melatonin 1 hour after light-on ZT01 (Zeitgeber time), administration of melatonin 1 hour before light-off ZT11. Melatonin was administered by gavage daily for 7 weeks at a standard exposure to day-night light (12:12). RESULTS. The application of melatonin affects the morphology and functional state of brown adipocytes independently of the administration time: the nuclear-cytoplasmic ratio increases due to an increase in the area of the nucleus against the unchanging cell area. The number of lipid drops increases in each adipocyte, but their size is decreased. The effect of different time of melatonin administration was manifested in the increase of brown adipose tissue weight, in the terms of evening administrations. CONCLUSION. The effects of different times of melatonin administration at the cytological level are manifested almost identically in the brown adipocytes functional state in all experimental groups. However, at the organism level in terms of evening administrations, an increase in the relative mass of brown adipose tissue is observed, but the size of brown adipocytes do not change, which may indicate the activation of the differentiation of brown adipocytes from the progenitor cells.


With the development of the electric power system in China, wind power, as a clean energy, can be utilised to optimise the structure of electrical energy. By reducing the emission of pollutants, it will benefit the sustainable development of the national economy and environment. In wind power projects, scientific and rational choices for the wind turbine generator in actual wind farm are critical since it is directly related to the economic benefits of wind power projects. By analysing the status of current wind power capacity at the scale of the globe and China, wind power is projected to play an increasingly important role in the future. On this basis, we developed the comprehensive evaluation system of wind turbine generator selection and established a comprehensive evaluation model based on BP neural network which was optimised by particle swarm. A real example was employed to verify the validity of the proposed method, thus can provide guideline of the evaluation of the wind turbine generators selection in wind farms.


PURPOSE: To provide the door opening/closing inspection device for an elevator which can easily detect the cause of the anomaly of a cage door and an elevator hall door. CONSTITUTION: The operation control for a cage 1 is executed by an operation controller 2, and the inspection for the opening/closing of the door of the cage 1 and an elevator hall door is carried out by an inspection device 3. The inspection device 3 receives a door opening instruction signal ZOPEN, door closing instruction signal ZCLOSE, signal of a car door switch GS, signal of a perfect closure detection switch CLS, signal of a perfect opening detection switch OLS, and the signal of an elevator hall door lock switch DS at each opening and closing of the door, and measures the operation time by an operation time measuring circuit 31, and each value is compared with the value stored in an initial value memorizing circuit 33 by a comparison judgement circuit 34, and the correctness of the opening/closing of the door is judged. COPYRIGHT: (C)1993,JPO&Japio


: The income of companies working on data markets steadily grows year by year. Private function evaluation (PFE) is a valuable tool in solving corresponding security problems. The task of Controlled Private Function Evaluation (CPFE) and its relaxed version (rCPFE) was proposed in [11]. We define an ideal functionality for the latter task and present a UC-secure realization of the functionality against static malicious parties. The core primitive is functional encryption (FE) and essentially this determines the conditions of realizability. Accordingly, in the case of non-adaptive FE-setting secure realization of the ideal functionality is achievable in the standard model, otherwise, accessibility of random oracle is required.


Twenty-five patients with deep thrombophlebitis, whose symptoms were of less than five days' duration, had serial venograms made before and after combined streptokinase-plasmin-anticoagulant therapy. Of 20 patients pre-senting with evidence of inflammation, 18 were asymptomatic within five days. Evidence provided by venograms suggests that thrombolysis of varying degree occurred in eight of 23 patients with comparable pre-treatment and post-treatment venograms. In only two patients was flow restored through a major venous channel. Thus, in most cases, no evidence was adduced that the administration of Thrombolysin® (derived from the euglobulin fraction of human plasma, activated with streptokinase and containing both preformed plasmin and plasminogen activator activity) added significantly to heparin therapy.


Abstract Two simple, efficient, and environmentally benign protocols for the synthesis of various N-arylacetamides via N-acetylation of arylamines and straightforward one-pot reductive acetylation of aromatic nitro compounds promoted by CuFe2O4 nanoparticles in water at reflux have been developed. The prepared CuFe2O4 MNPs are well known and fully characterized by various techniques. Furthermore, the CuFe2O4 NPs easily separated from the reaction environment using an external magnetic field and can be reused for several times without significant loss of its activity for both mentioned reactions.


Objective To investigate the effect of adenosine disodium triphosphate( ADT) on myocardial infarction in rats. Methods The acute myocardial infarction rat model was induced by ligation of the left anterior descending coronary artery. The model rats were divided into five groups randomly: model group,ADT 1,2,4 mg·( kg·d)- 1and enalaprilat 10 mg·( kg·d)- 1,and the other 8 rats received sham surgery.The effect of ADT on myocardial infarction rats included left ventricular of configuration,the degree of myocardial hypertrophy and pulmonary edema,scope of myocardial infarction and myocardial remodeling were determined by color Doppler echocardiography,hemodynamic,heart weight,lung water content and the content of collagen type Ⅰand Ⅲ after continuous dosing for 30 days. Results Compared with model,ADT can improve left ventricular function of myocardial infarction rats,improve significantly left ventricular ejection fraction significantly,reduce left ventricular end- diastolic pressure and cavity size,the lung water content and the range of myocardial infarction,inhibit ventricular remodeling,etc. Conclusion ADT can improve the cardiac function after myocardial infarction in rats.


This paper presents two fault-diagnosis examples for the winding deformation of electric power transformer using frequency response analysis.It is pointed out that the hidden electrical and mechanical troubles in power transformers can be effectively detected by comparing the frequency response curves before and after the detection.This technique plays a significant role in the secure operation of the transformers and power network.However,frequency response analysis can not detect some faults such as simplex twist deformation.More experimentation and judgment approaches are needed in the diagnosis of power transformer winding deformation.


— When estimating low damage probability of a building to the 10 - 6 level, even with subset MCMC, response analysis of over 150,000 times is necessary. It requires much CPU time and therefore unrealistic. In this paper, once after reducing the number of response analysis without using subset method, we create a n dimensional regression hypersurface (a deep learning regression model) that predicts low damage probability of a building. This enables quantitative estimation with dramatically less effort.


Gold medal winners of the POLAGRA-PREMIERY 2010 competition have been presented in the paper. The nineteen products, that are the Gold Medal winners, are following: Automated System For Bidirectional Communication Between The Baler And Tractor, manufactured by JOHN DEERE USINE D'ARC-LES GRAY, France and JOHN DEERE WERKE MANHEIM, Germany; JOHN DEERE 8345R Farm Tractor, manufactured by Waterloo Works, U.S.A.; MAJA Z – 583 Wrapper, manufactured by SIPMA S.A., Lublin, Poland; New Holland T7070 Auto Command Farm Tractor, manufactured by NEW HOLLAND, Basildon, Great Britain; POLY-series Pumps For Spraying Machines by Bertolini, manufactured by IDROMECCANICA BERTOLINI S.p.A., Italy; Valtra T202 Direct Farm Tractor, manufactured by Valtra Inc., Finland; VECTOR Tiller, manufactured by Kockerling GmbH & Co. KG, Germany; MARATHON Net in BALE+ technology, manufactured by TAMA PLASTIC INDUSTRY, Israel; TERRAFLEX In-Soil Slurry Applicator, manufactured by Joskin Polska sp. z o.o., Trzcianka, Poland; N-266 Manure Spreader, manufactured by POL-MOT Warfama S.A, Dobre Miasto, Poland; GigaCUT 860 S/T Mower Set, manufactured by SaMASZ inz. Antoni Stolarski, Bialystok, Poland; Quick Connect Automated Top Hitch, manufactured by LEMKEN GmbH & Co. KG, Germany; Fendt 209 Vario Farm Tractor, manufactured by AGCO GmbH FENDT, Germany; Massey Ferguson MF 8690 Farm Tractor, manufactured by AGCO S.A.; TVI Albuz Rotational Ejector Spreader With Hollow Cones, manufactured by Saint-Gobain Ceramics, France; AVANT 420 Mini Loader, manufactured by AVANT TECNO OY, Finland; HS 1,5 Hydroseeder, manufactured by ŁUKOMET Krzysztof Łuszczyk, Calowanie, Poland; PUMA CVX 225 Farm Tractor, manufactured by CASE IH, Austria; EDAS Navigated Spraying Machine for environmentally-friendly orchard protection, manufactured by Agroengineering Center of Pomology and Floriculture Research Institute in Skierniewice. AGROCOM Polska. Software and new solutions for agriculture. Jerzy Koronczok, Żedowice, Poland.


Schweinfurthinol (I), isolated from Canarium schweinfurthii, possesses an (S) configuration as is proven by a chiral-pool based synthesis of both enantiomers.


The minimum energy of the first conduction subband varies with gate voltage in trigate SOI MOSFETs in subthreshold operation. In an inversion-mode device, the energy level of the lowest subband increases when the electron concentration increases, while it decreases under the same conditions in some accumulation-mode devices. As a result of this quantum effect, the subthreshold swing of accumulation-mode trigate FETs is smaller than predicted by classical theory, while that of inversion-mode devices is higher. This effect is not observed in FinFETs and GAA MOSFETs and can be amplified by modifying the device cross section.


When Daniel Levy, M.D., FAAP, started working as a pediatrician, he most often treated patients for common illnesses like chicken pox and ear infections.

![Figure][1]

Dr. Levy

But over the past decade, he has noted a dramatic shift in the kinds of cases parents ask him to treat. More


Considering a bidirectional amplify-and-forward based multi-carrier multi-relay network, we formulate two different joint power allocation and network beamforming problems. In the first formulation, we aim to minimize the total transmit power of the network, subject to two constraints on the transceiver rates. In the second problem, our goal is to maximize the sum-rate of the two transceivers subject to a constraint on the total network transmit power. In both problems, the design parameters include the relay beamforming weights and the transceiver power allocations over all subcarriers. We propose a two-step iterative method to tackle each problem and show that each method leads to (at least) a locally optimum solution. Each iterative method alternates between solving the underlying problem for one set of variables while the other set is fixed and vice versa. Each subproblem is shown to be amenable to a computationally efficient solution. Our simulation results show the efficiency of the proposed techniques.


Introduction. To limit peach brown rot incidence in a mid-season peach orchard cv. 'Conquise', three combinations of tree training and pruning treatments were assessed: open vase training with conventional pruning (Control); open vase with centrifugal pruning (CentP); vertical axis training with centrifugal pruning (Axis). Materials and methods. The test orchard was divided into four blocks, each with the three tree management treatments in a randomized complete block design. Brown rot incidence as well as fruit production and quality were assessed over five successive years. Results and discussion. The lowest brown rot incidence values were detected under Axis and the highest under Control, with values for CentP being intermediate. The reduced incidences under CentP and Axis training were observed around two weeks before fruit maturity and were maintained until post-harvest storage. Compared to the Control, CentP and Axis resulted in higher trunk cross sectional areas, yields and monetary returns. CentP and Axis also tended to enhance peach internal quality, i . e ., increase of total soluble solids, but work time devoted to pruning and thinning under CentP and Axis was greater than for the Control. Conclusion. Appropriate tree management, a vertical axis training system and centrifugal pruning, appears to decrease peach disease sensitivity. This could result in reduced use of pesticide sprays for brown rot control.


The effects of glucocorticoids on the regulation of rat liver S-adenosylmethionine synthetase were studied in vivo and in two culture systems. Livers from adrenalectomized animals were examined for enzyme activity, immunoreactive protein, and messenger RNA (mRNA) content. All three parameters showed a similar trend, i.e. they decreased 3-fold after adrenalectomy and increased over the control values upon triamcinolone replacement. These results suggested that glucocorticoid regulation of hepatic S-adenosylmethionine synthetase was mediated at the mRNA level. Triamcinolone and dexamethasone increased S-adenosylmethionine synthetase mRNA content in a timeand dose-dependent manner in both rat hepatoma H35 cells and primary cultures of adult rat hepatocytes. The kinetics of mRNA induction were identical in both culture systems, indicating that the hormone-mediated response is independent of the differentiated state of the cell. Insulin blocked the inducing effect of glucocorticoids on S-adenosylmethionine synthetase mRNA in a dose-dependent manner. On the other hand, the triamcinolonedependent increase in mRNA levels was completely abolished by treatment with actinomycin D, whereas cycloheximide did not affect this response. The transcription rate of the gene, as measured by run-on assay, increased 3-fold after hormone addition. Transient transfections of H35 cells with 1.4 kilobases of the 59-flanking region of the hepatic S-adenosylmethionine synthetase gene fused to a luciferase reporter gene showed that promoter activity is also increased 3-fold after triamcinolone treatment, suggesting that this promoter region contains the sequence elements necessary to confer glucocorticoid responsiveness. In addition to the transcriptional control of the hepatic S-adenosylmethionine synthetase gene, our results suggest that glucocorticoids may be acting at a posttranscriptional level. (Endocrinology 138: 1251–1258, 1997) S (AdoMet) synthetase (EC 126.96.36.199) is a housekeeping enzyme that catalyzes the only known route of biosynthesis of AdoMet in a reaction that involves the transfer of the adenosyl moiety from ATP to the sulfur atom of methionine (1). The relevance of this reaction has been recently emphasized by the fact that AdoMet synthetase has been found to be included in the minimal set of functional gene products necessary for independent life (2). This is due to the central position that AdoMet occupies in cellular metabolism; it is the donor of methyl groups for most of transmethylation reactions, which are essential to maintain cellular structure and function, and serves as the source of propylamine moieties for polyamine biosynthesis (3, 4). In mammalian liver, this metabolite also participates in the transsulfuration pathway (5), which leads to the synthesis of compounds involved in maintaining the normal redox potential, such as glutathione. Among mammalian tissues, liver exhibits the highest enzyme specific activity, consistent with the fact that the majority of methionine taken up from the diet is metabolized by this pathway in this organ (6). Related to this, anAdoMet synthetase isoenzyme is selectively expressed in the liver, whereas in other tissues, the so-called extrahepatic or kidney-type AdoMet synthetase is present (reviewed in Refs. 7 and 8). Over the past few years, much effort has been devoted to study of the regulation of hepatic AdoMet synthetase under various pathophysiological conditions. The specific activity of the enzyme has been shown to be altered in response to tissue damage, concomitantly with a severe impairment of methionine metabolism. For instance, a marked reduction in enzyme activity has been found in human alcoholic (9, 10), biliary (11), and posthepatitic cirrhosis (9) as well as in different experimental models of liver injury (see Ref. 8 and references therein). Various pieces of evidence have led to the suggestion that the activity of the enzyme could be regulated under these conditions by the oxidation state of its thiol groups (12–15). The involvement of other possible regulatory mechanism, such as the modulation of the messenger RNA (mRNA) levels, has been also explored. Thus, in a rat model of carbon tetrachloride-induced liver damage, despite the marked reduction in enzyme activity, the levels of the corresponding mRNA have been found to be similar to those detected in normal liver (16), a findingwhich agreeswith that derived from the analysis of liver biopsies from alcoholic cirrhotic patients (17). These results supported the idea that the decrease in hepatic AdoMet synthetase activity observed under several pathological situations was due to posttranslational events rather than to a reduced expression of the gene. The activity of the enzyme has been also found to be influenced by hormonal stimuli. In this regard, it was previously reported that hepatic AdoMet synthetase activity is altered in adrenalectomized animals (18–20), suggesting a role for glucocorticoids in its regulation. These hormones account for pleitropic effects in liver, and its action on hepatic AdoMet synthetase could be of major physiological releReceived September 4, 1996. Address all correspondence and requests for reprints to: Dr. José M. Mato, Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Cientificas, Arturo Duperier 4, 28029 Madrid, Spain. E-mail: firstname.lastname@example.com. * This work was supported in part by grants from the Fondo de Investigaciones Sanitarias, Dirección General de Investigaciones Cientı́ficas, and Europharma. † Fellow of the Ministerio de Educación y Ciencia. 0013-7227/97/$03.00/0 Vol. 138, No. 3 Endocrinology Printed in U.S.A. Copyright © 1997 by The Endocrine Society


The purpose of this Thesis is to study the nonlinear analysis of antisymmetrically laminated composite beams including shear deformation subjected to harmonic excitation, using a 20-degree of freedom finite element beam. The beam has 10 degrees of freedom at each node: The axial displacements, the transverse deflection due to bending and transverse shear, the twisting angle, the in-plane shear rotation, and their derivatives along the axial direction. In this study, the effect of different parameters such as damping, shear deformation and different edge conditions on the steady-state frequency-responce will be investigated. The analysis was based on the use of finite element methodology for composite laminated beam structures. The harmonic force matrix represents the externally applied force in matrix form, instead of a vector form. Thus the analysis of nonlinear forced vibration can be performed efficiently to get a converged solution. The analysis was also based on the nonlinear stiffness matrix and both in-plane longitudinal, and transverse deflections are included in the formulation. The amplitude-frequency ratios for different boundary conditions, lamination angles, number of plies and thickness to length ratios are presented. The finite element results are compared with available approximate continuum solutions.


To counter the increasing number of online threats for users' privacy and security, this paper explores the design of an ambient security indicator, in form of a standard keyboard illuminated in different colors, and equipped with additional buttons and vibration functionality. We present the results of a focus group study, which notably influenced the design, and discuss a prototypical implementation called Moody Board.


Background While abatacept (ABA), launched in 2010, has been used to treat more than 8,000 rheumatoid arthritis (RA) patients in Japan, factors affecting clinical, functional, and structural remission remain unclear. Objectives To identify the baseline clinical parameters associated with ABA effectiveness. Methods Orencia® as Biological Intensive Treatment for RA (ORBIT) is a retrospective study conducted in four rheumatology institutes. A total of 141 patients were intravenously administered ABA 10 mg/kg every 4 weeks. Disease activity, disability, and structural damage were assessed using DAS28-ESR and SDAI, HAQ-DI, and modified total Sharp score (mTSS), respectively. Last observation carried forward method and linear extrapolation were used for missing clinical and radiographic data. Results Baseline characteristics of the 141 analyzed patients were as follows: mean age, 60.8±13.5 years; mean disease duration, 10.2±9.2 years; concomitant use of methotrexate (MTX), 74.5%; MTX dose, 8.0±2.8 mg/week; concomitant use of predonisolone (PSL), 40.4%; PSL dose, 5.2±3.4 mg/day; prior treatment with biologic agents, 51.8%; DAS28-ESR, 5.2±1.4; SDAI, 24.8±12.5; HAQ-DI, 1.4±0.8; and mTSS, 59.4. At week 24 and 52, 80.1% and 67.4% continued ABA treatment, respectively. The main reason for discontinuation was lack of efficacy (28/46 60.9%). The clinical remission defined by DAS28-ESR<2.6 and SDAI≤3.3 were 15.7% and 15.6% at week 24, and 28.6% and 21.3% at week 52, respectively. A total of 36.0% of patients achieved functional remission (HAQ-DI≤0.5). X-ray data were available for assessment in 83.0% of patients, and 54.7% of patients showed ΔmTSS≤0.5. Results of univariate logistic regression showed factors affecting SDAI remission and functional remission at week 52 to be disease duration (p=0.005 and p=0.014), mTSS at week 0 (p=0.0002 and p=0.0007), HAQ-DI score at week 0 (both p<0.0001), prior treatment with biologic agents (p=0.002 and p=0.003). We noted no factors affecting structural remission at week 52. Conclusions ABA has demonstrated clinical, functional, and structural effectiveness. No prior treatment with biologic agents is likely to lead clinical and functional remission. Disclosure of Interest T. Takeuchi Grant/research support from: Abott Japan Co., LTD., Astellas Pharma, Bristol-Myers K.K., Chugai Pharmaceutical Co., LTD., Daiichi Sankyo Co., LTD., Eisai Co., LTD., Janssen Pharmaceutical K.K., Mitsubishi Tanabe Pharma Co., Nippon Shinyaku Co., LTD., Otsuka Pharmaceutical, Pfizer Japan Inc., Sanofi-aventis K.K., Santen Pharmaceutical, Takeda Pharmaceutical Co., LTD., Teijin Phrma Ltd., Consultant for: Astra Zeneca, K.K., Eli-Lilly Japan K.K., Novartis Pharma K.K., Mitsubishi Tanabe Pharma Co., Asahi Kasei Medical K.K., Speakers bureau: Abott Japan Co., LTD., Bristol-Myers K.K., Chugai Pharmaceutical Co., LTD., Eisai Co., LTD., Janssen Pharmaceutical K.K., Mitsubishi Tanabe Pharma Co., Pfizer Japan Inc., Takeda Pharmaceutical Co., LTD., Y. Tanaka Grant/research support from: Bristol-Myers Squibb, MSD K.K., Chugai Pharma Co., Ltd., Mitsubishi-Tanabe Pharma Co., Ltd., Astellas Pharma Inc., Abbott Japan Co., Ltd., Eisai Co., Ltd. and Janssen Pharmaceutical K.K., Consultant for: Mitsubishi-Tanabe Pharma Co., Ltd., Abbott Japan Co., Ltd., Eisai Co., Ltd., Chugai Pharma Co., Ltd., Janssen Pharma K.K., Santen Pharma Co., Ltd., Pfizer Japan Inc., Astellas Pharma Inc., Daiichi-Sankyo Co., Ltd., GlaxoSmithKlineK.K., Astra-Zeneca, Otsuka Pharma Co., Ltd., Actelion Pharma Japan Ltd., Eli Lilly Japan K.K., Nippon Kayaku Co., Ltd., UCB Japan Co., Ltd., Quintiles Transnational Japan Co. Ltd., Ono Pharma Co., Ltd., and Novartis Pharma K.K, Speakers bureau: Mitsubishi-Tanabe Pharma Co., Ltd., Abbott Japan Co., Ltd., Eisai Co., Ltd., Chugai Pharma Co., Ltd., Janssen Pharma K.K., Santen Pharma Co., Ltd., Pfizer Japan Inc., Astellas Pharma Inc., Daiichi-Sankyo Co., Ltd., GlaxoSmithKlineK.K., Astra-Zeneca, Otsuka Pharma Co., Ltd., Actelion Pharma Japan Ltd., Eli Lilly Japan K.K., Nippon Kayaku Co., Ltd., UCB Japan Co., Ltd., Quintiles Transnational Japan Co. Ltd., Ono Pharma Co., Ltd., and Novartis Pharma K.K, K. Amano Consultant for: Bristol -Myers Squibb co., J. Kikuchi Consultant for: Pfizer Japan Inc., E. Tanaka: None Declared, S. Hirata: None Declared, H. Nagasawa: None Declared, H. Yasuoka: None Declared, H. Yamanaka Grant/research support from: Abbott, Astellas, Bristol-Myers Squibb, Chugai, Eisai, Janssen, Mitsubishi-Tanabe, Pfizer, Takeda, UCB, Consultant for: Abbott, Astellas, Bristol-Myers Squibb, Chugai, Eisai, Janssen, Mitsubishi-Tanabe, Pfizer, Takeda, UCB, Consultant for: Abbott, Astellas, Bristol-Myers Squibb, Chugai, Eisai, Janssen, Mitsubishi-Tanabe, Pfizer, Takeda, UCB, Consultant for: Abbott, Astellas, Bristol-Myers Squibb, Chugai, Eisai, Janssen, Mitsubishi-Tanabe, Pfizer, Takeda, UCB


BALANCED FOOD FOR RUMINANTS AND THEIR MANUFACTURING METHOD. THIS IS THE DESCRIPTION OF THE USE OF AGRICULTURAL WASTE FORM OF STRAW CEREAL OR CHEMICALLY TREATED prunings FRUIT PLANT SAME TIME AS THE RESIDUAL LIQUID FROM mOLASSES BEET SUGAR IN THE MANUFACTURE OF FOOD SUITABLE BALANCED FEED WITH sTOMACH TO SEVERAL POCKETS. THE FINAL MIXTURE CONTAINS USEFUL AGRICULTURAL WASTE AS MAIN COMPONENT AND UP TO 60 PULP SUGAR BEET, THE REST BEING MADE CONVENTIONAL ADDITIVE.


When flow separation and side-load behavior is investigated for different nozzle concepts or when design considerations for advanced nozzle concepts are experimentally screened, the initial experimental effort is generally limited to subscale experiments with high-quality diagnostics. However, one fundamental question always arises: How should these test results be scaled to a potential full-scale design or application? Different approaches exist, including the use of characteristic numbers for normalization and analytical and numerical models. It is shown that analytical models, being based on physical origins and dominated by inviscid flow phenomena, may result in high accuracy for full-scale prediction. In contrast, it is shown that for flow regions dominated by viscous effects significant differences between cold- and hot-gas experiments are observed, which makes a direct scaling from cold-gas subscale to hot-gas full-scale difficult. For scaling, an intermediate step in the scaling rationale with hot-firing tests is foreseen. Demonstrated by results from hot-firing tests with Vulcain subscale nozzles, it is shown that a geometrical scaling is possible for similar hot-gas flow properties. These test results, obtained with a 40-kN thrust chamber at representative combustion chamber operation conditions, are presented and discussed in detail.


THE PRIMARY purpose of this study was to analyze the answers given to direct questions by four groups of elementary school children and one group of adults, regarding natural phenom ena; to classify their explanations; to determine the method and types of explanations used by these groups when they explain typical natural phenomena, and to compare these findings with the results of previous investigators. The assumption was made that an analysis and classification of explanations would not cor roborate the thesis that there is an age-related stage in children's thinking. No attempt was made to present an interpretation of the work ings of the children's or adult's minds. The na ture of the responses themselves were analyzed to determine how children and adults explain typical phenomena.


We are developing the pumerical model called the RIAM−COMPACT (gesearch 1nstitute for Applied Mechanics, dntmputational Rrediction of△irflow over 1omplex工errain). The object domain of this numerical model is from several m to several km, and can predict the airflow and the gas'diffusion over complex terrain with h'igh' precision. Using the RIAM−COMPACT, the performance o.f two kinds of 64−bit microprocessors 'was evaluated under' 狽?e same conditibns. The calculation of neutral−airflow' past a steep isolated−hill was made in the present study. The target computers were a SMP (ES!ymmetric 1Y1ulti−Rrocessor, 2 and 4CPU) based on the lntel ltanium2 processor and'the AMP Opteron processor. The parallel computing using the automatic parallelization option was performed. The obtained elapsed time was compared with a I PE of VPP5000 0f FUJITSU which is a vector type computer. Consequently, it is shown that the SMP (2, 4CPU) based on the lntel Itanium2 processor and the AMP Opteron processor has about the same performan'ce as a 1


Public Key Cryptosystems.- Generating RSA Moduli with a Predetermined Portion.- Generation of Shared RSA Keys by Two Parties.- An Attack on RSA Given a Small Fraction of the Private Key Bits.- C ?+ * and HM: Variations Around Two Schemes of T. Matsumoto and H. Imai.- Invited Talk.- ECC/DLP and Factoring-Based Cryptography: A Tale of Two Families (Invited Lecture).- Elliptic Curve Cryptosystems.- Efficient Elliptic Curve Exponentiation Using Mixed Coordinates.- Efficient Implementation of Schoof's Algorithm.- Design of Hyperelliptic Cryptosystems in Small Characteristic and a Software Implementation over F2 n.- Construction of Secure Elliptic Cryptosystems Using CM Tests and Liftings.- Elliptic Curve Discrete Logarithms and the Index Calculus.- Cryptanalysis 1.- Cryptanalysis of Rijmen-Preneel Trapdoor Ciphers.- Improved Truncated Differential Attacks on SAFER.- Optimal Resistance Against the Davies and Murphy Attack.- Signature.- A Group Signature Scheme with Improved Efficiency (Extended Abstract).- A Study on the Proposed Korean Digital Signature Algorithm.- Cryptanlysis 2.- Cryptanalysis of the Original McEliece Cryptosystem.- Improving the Security of the McEliece Public-Key Cryptosystem.- Cryptanalysis in Prime Order Subgroups of Z n * .- Finite Automata.- Weak Invertibility of Finite Automata and Cryptanalysis on FAPKC.- Authentication Codes.- Bounds and Constructions for Multireceiver Authentication Codes.- Electronic Cash.- Fair Off-Line e-Cash Made Easy.- Off-line Fair Payment Protocols using Convertible Signatures.- Efficient Fair Exchange with Verifiable Confirmation of Signatures.- Adaptively Secure Oblivious Transfer.- Steam Ciphers.- ML-Sequences over Rings Z/(2e): I. Constructions of Nondegenerative ML-Sequences II. Injectivness of Compression Mappings of New Classes.- Analysis Methods for (Alleged) RC4.- Reduced Complexity Correlation Attacks on Two Clock-Controlled Generators.- Cryptographic Protocols.- A New and Efficient All-Or-Nothing Disclosure of Secrets Protocol.- The Beguin-Quisquater Server-Aided RSA Protocol from Crypto '95 is not Secure.- Key Escrow.- Equitable Key Escrow with Limited Time Span (or, How to Enforce Time Expiration Cryptographically) Extended Abstract.- New Cryptography.- Audio and Optical Cryptography.- Information Theory.- Strong Security Against Active Attacks in Information-Theoretic Secret-Key Agreement.- Some Bounds and a Construction for Secure Broadcast Encryption.


This article analyzes the concept of a trade union and its legal nature, the role and importance of trade unions as an institution of civil society in Uzbekistan, the functions and basic principles of trade union activity, the organizational and legal foundations of trade unions. The article also provides a constitutional and legal analysis of the concept of a trade union and its legal nature, an analysis of the functions and basic principles of trade union activity, a study of the stages of development of the legislative system of trade unions in Uzbekistan, organizational and legal issues of trade union activity, a study, an analysis of the legal nature of documents adopted by trade unions, comparatively - legal analysis of foreign experience in organizing trade union activities, determining priority areas for improving trade union activities, developing proposals and recommendations for improving the legislation governing this activity, and other issues were also analyzed


Abstract : The work of Project 1032 of the RACE program definition phase is summarized. The background and problems relating to coherent multichannel techniques for integrated communications subscriber lines, assumptions, and recent relevant state-of-the-art developments are discussed, including a commentary on Level III of the RACE definition phase scenario (ROPS-3). The main hardware advantage will occur in the central office in the implementation of broadband distribution services through a high degree of laser sharing. The selection of TV Channels is carried out within the TV set and not by switching in the central office. This reduces problems in connection with signaling bursts and is an important privacy advantage. Key components for CMC techniques are electronically tunable distributed feedback lasers, which should not be affected by reflections or compact laser isolator modules.


The simple harmonic vibration, damping vibration and forced vibration of an oscillator attached to the massless spring are always discussed in general mechanics courses. In this article, we focus on the heavy-spring conditions. We first investigate the general situation where both viscous resistance and applied force are considered under the perspective of the renormalization group theory. Then we use analytic method to study the damped oscillation of an oscillator attached to the heavy spring, where renormalization method fails to work.


A classical result by Guibas and Odlyzko obtained in 1981 gives the generating function for the number of strings that avoid a given set of substrings with the property that no substring is contained in any of the others. In this paper, we give an analogue of this result for the enumeration of compositions that avoid a given set of prohibited substrings, subject to the compositions' length (number of parts) and weight. We also give examples of families of strings to be avoided that allow for an explicit formula for the generating function. Our results extend recent results by Myers on avoidance of strings in compositions subject to weight, but not length.


[Purpose] To construct the recombinant adeno-associated virus vector expressing VEGF121 and to provide an experimental basis for clinical research and its expression in vitro.[Methods] Human VEGF121 gene was induced by RT-PCR and cloned into pAAV-MCS vector for constructing pAAV-VEGF121 expression vector.pAAV-VEGF121 vector was identified with double digestion and DNA sequencing.[Results] RT-PCR amplified a 444bp specific electrophoretic band.The results of double digestion showed that pAAV-VEGF121 vector was successfully constructed with DNA sequencing similar to VEGF121mRNA.[Conclusion] pAAV-VEGF121 vector is successfully constructed and establishes an experimental basis for further exploring the mechanism of VEGF gene.


The extent to which the Edwardian Conservative party suffered from a crisis of leadership, ideas, and confidence and how a potentially lethal challenge came not from the Liberals or Labour but from its own radicalized right wing are examined in Rebel on the Right. This book provides an in-depth study of the early political activities of Henry Page Croft (1881-1947). Croft's and the party's youthful and radicalized right wing attempted to transform the dysfunctional political party into a modern, aggressive political force with a new ideological orthodoxy.


Objective To approach of multiplex PCR for the pneumonic bacterial etiologic diagnosis in littoral of Zhejiang,direct etiologic diagnosis and antibiotic rational use,and understand the distribution of bacterial etiology. Methods 188 hospitalized children in our hospital,were collected deep tracheal aspirate at the time of hospitalization. The respiratory tract secretions were immediately sent for bacterial culture. Then we extracted DNA from secretions. Simultaneously,14 respiratory tract pathogenic bacterium were detected by multiplex PCR. Amplification products were identified by the Luminex 100 suspension array. The sensitivity and specificity of multiplex PCR for the bacteria were evaluated. The affect for pneumonic bacterial etiologic distribution was analysised by the combined detection with bacterial culture and multiplex PCR assay. Results Of the 188 respiratory tract specimens, 114 were positive by bacteria culture. The positive rate of culture was 60. 6%( 114 /188). The target gene were detected by multiplex PCR from 75 specimen,the positive rate of multiplex PCR was 39. 9%( 75 /188). For the 14 kinds of bacterium designed by multiplex PCR,compared with the culture,the sensitivity,specificity and coincidence of multiplex PCR weres 51. 0%,68. 0% and 58. 3%,respectively. Multiplex PCR was more sensitive than culture in the detection of Streptococcus penumoniae( 36 /188 19. 1% vs 7 /188 3. 7%,P 0. 01). The total positive rate by combined detection of culture and multiplex PCR assay was 78. 2%( 147 /188). The combined detection may increase the positive case of Staphylococcus aureus, Hemophilus influenzae, Staphylococcus aureus, Pseudomonas aeruginosa and Acinetobacter baumannii. The mixed infection with Mycoplasma pneumoniae and bacterium was 16 by multiplex PCR. Of which,the most common mixed infection was Mycoplasma pneumoniae and Hemophilis influenzae,it was 50. 0%( 8 /16). Conclusion Multiplex PCR is highly sensitive for detection of Streptococcus penumoniae causing pneumonia in children. The combined detection of bacterial culture and multiplex PCR assay may increase the positive rate of bacterial pathogens in hospitalized children with CAP and can really demonstrate the distribution of bacterial etiology. Multiplex PCR can timely indicate the mixed infection with Mycoplasma pneumoniae and bacterium in etiologic agent causing CAP.


The article is devoted to the problems of forming and developing lexical skills by modern multimedia means of visualization in the ESL classroom. Modern technologies have been led to new possibilities to integrate multimedia tools and means of visualization in the ESL classroom. The aim of this paper is to analyze the current ESL coursebooks and coursebook supplements and give recommendations to teachers how to use the sufficient range of means of visualization effectively. As a part of research different types of questionnaires were handed to teachers and first-year students of Bachelor's Program "Pedagogical Education (double major) and Second Foreign language " (5 years, full time) of Kazan State University. After this, a set of classes was organized for two groups of first-year students. The outcomes have been measured with qualitative and quantitative methods. The results show that the teachers do not use means of visualization and are not ready to make them the integral part of everyday lessons due to time management issues, lack of methodical ways of organization of educational process. Due to these results it can be resumed that using multimedia means of visualization as tools in the ESL classroom is highly beneficial for students and enhanced the learning process.


The purpose of this report is to present data and findings acquired during the drilling and construction of seven bioremediation wells in the 100-N Area in conjunction with remediation of the UPR-100-N-17 petroleum waste site.


Magnetization measurements are reported for single crystals of PrAl2 in the range from 4.2K to 30K for magnetic fields up to 150 kOe applied in the (100), (110) and (111) directions. For these measurements, together with the magnetization results obtained earlier for TbAl2 the authors give a quantitative quantum mechanical description of the magnetization and the related magnetocrystalline anisotropy in terms of a cubic crystalline electric field and an isotropic exchange interaction. The parameters used in this description can be unified to good approximation to all REAl2 intermetallic compounds where detailed experiments are available.


This paper provides a new method for coordinate transformation between these two types and based on Newton's iterative method,which is derived from map projection principle. In the process of transformation,from plane rectangular coordinate to geographical coordinate ,namely,map projection reversing transformation is carried out by computer iterative process,and this method has the merits of high resolution of transformation,fast convergence and convenient coding.


We study the problem of bounding the number of primes p ≤ x in an arithmetic progression for which the largest prime factor of p − h does not exceed y.


Product safety and product liability considerations are explored for photovoltaic module/array devices. A general review of photovoltaic literature was made using computerized literature searches. A literature search was also made of relevant legal material as it applies to design. Recommendations are made to minimize or eliminate perceived hazards in manufacture and use of a photovoltaic module/array. (MHR)


Previous flexural studies on Hawaii were done under the assumption that the amount of deflection caused by the loading of the islands is equivalent to the change in Moho depth. Crustal profiles based on seismic refraction suggest an alternative measurement of deflection as the change in depth of the boundary between the basement and oceanic layers. This alternative implies the existence of an unflexed portion of the crust that represents the difference between the basement-oceanic and Moho displacements and that effectively lessens the load due to its buoyancy. This material represents either a phase change of mantle to crustal material or intrusion into the lower crust. From the basic equations of flexure and Airy isostasy a more general form of equilibrium equation is developed and can be interpreted as an addition of an elastic flexure term to the isostatic equations or an addition of a term accounting for changes in the crustal column to the presently used flexure equations. The study of simple models indicates that the most reliable parameter in estimating flexural rigidity is the wavelength of the flexure. When elastic flexure and buoyancy of added crust are considered in relation to the Hawaiian Ridge at Oahu, a plausible case is made for the presence of both. A flexural rigidity of about 1.2×1023 N m for an unfractured lithosphere is derived for the Hawaiian Islands; this value agrees favorably with results of other studies.


The IPSec is a basic security mechanism of the IPv6 protocol, which can guarantee an integrity and confidentiality of data that transmit between two corresponding hosts. Also, both data and communication subjects can be authenticated using the IPSec mechanism. However, it is difficult that the IPSec mechanism protects major important network from attacks which transmit mass abnormal IPSec traffic in session-configuration or communication phases. In this paper, we present a design of the security system that can effectively detect and defeat abnormal IPSec traffic, which is encrypted by the ESP extension header, using the IPSec Session and Configuration table without any decryption. This security system is closely based on a multi-tier attack mitigation mechanism which is based on network bandwidth management and aims to counteract DDoS attacks and DoS effects of worm activity.


Dapagliflozin can be added to existing treatment to reduce the risk of hospitalization for heart failure in patients with type 2 diabetes who have established CVD or are at high risk of CVD. It may also decrease the risk of renal disease progression and death from renal failure.


The city of Semarang is one of the 10 major cities in Indonesia that are developing towards the metropolis. Urban infrastructure develops, resulting in the use of vegetation land to be converted into build up land. The increasingly hot climate of the city will disrupt the comfort of residents. Urban design and planning should consider land use change. Good planning will have a very good effect on the city's climate system. This study aims to examine the phenomenon of micro-climate change in the city with the algorithm of the Temperature Heat Index (Leisure Index). The assessment starts from the Land Surface Temperature algorithm, from here model of Urban Heat Island (UHI) can be done. The distribution of UHI phenomena is derived from Land Surface Temperature. The UHI mitigation recommendation for Semarang City is based on land cover. The method used is the Remote Sensing approach through some spatial data extraction from satellite imagery. Data processing is done by using multi-temporal data of Landsat 8 satellite imagery. The result is presented in thematic map of LST, UHI, and Mitigation model map. Mitigation that can be done is the physical modification of the building, like the use of material with high albedo, the application of green wall, green roof, greening parking lots, and the addition of vegetation around the building and along the road. Besides, it is also necessary to monitor the change of land function and its suitability with the Urban Land use Plan of Semarang City.


There are few Optics contents along the primary and secondary studies in Spain. So, the relation between Optics and Technology is usually poorly known by the students. As a consequence, the number of students in Physics in general, and Optics in particular is low. In this paper we explain a project to show some topics in Optics Technology in a primary-secondary school. This project involves some Optics teachers in the Autonomous University of Barcelona (UAB) and a group of teachers and students of a primary-secondary school also in Barcelona (I.E.S. Costa i Llobera). Several Optics posters (made by the SPIE) were shown during one week. More than 200 students from 8 to 17 years old visited the Optics exhibition during this week. A group of 4 students (17 years old) were trained to show the posters to younger students. For this study we chose three age levels. For each level, a 50% of the students attended the exhibition and the rest didn't attend the poster session. So, it was possible to realize a survey to check whether some knowledge differences appeared between the two groups. A questionnaire was fulfilled by these groups. The results of this survey show that a significant new knowledge in Optics was learned by the students.


A precision information collating device is disclosed. The device comprises means for inputting keywords and key phrases and defining level of traverse for establishing inter links and interdependencies between keywords and key phrases entered and using previously stored interlinks and interdependencies to form a map. The device facilitates searching for keywords and key phrases and filtering out unwanted results, indexing, rating and posting of the result obtained and means for browsing the result.


A model of the mammalian retina and the behavior of the first layers in the visual cortex is reported. The building blocks are optically programmable logic cells. A model of the retina, similar to the one reported by Dowling (1987) is presented. From the model of the visual cortex obtained, some types of symmetries and asymmetries are possible to be detected.


In an axial-flow pump unit with conventional stator and diftllser, often considerable energy is still present in the swirl (rotation) of the liquid leaving the stator. This energy will eventually be lost from the pump system. In this experimental investigation a new design, combining the stator and diffuser together into a single component, ·was tested for its effectiveness in recovering this energy and thereby improving the performance of an industry sized single-stage axial-flow pump unit. Measurements of static pressure rise along the new stator-difTuser and of the swirl angle of the fluid leaving the pump unit indicate that the new design performs better than the conventional one, as a component. However, efticiency of the whole pump unit is in general slightly reduced with the new design. A number of factors were identified as contributing to this performance degradation. Most notable are the poor matching of the fluid's and vanes' angles at the component's inlet and the sudden expansion of the flow geometry at the component's outlet. It is thus expected that when these £.'lctors have been adequately addressed, the new design should improve the pump's overall performance.


In this paper, the thermal integrity of near-memory computing in 3D integrated deep neural network (DNN) accelerators is investigated. Both conventional memory technologies (such as SRAM and DRAM) and emerging resistive memory (ReRAM) technology are considered. Through silicon via (TSV) based 3D integration and monolithic inter-tier via (MIV) based 3D technologies are leveraged for near-memory computing. The results demonstrate that monolithic 3D integrated DNN accelerator is thermally more feasible than TSV-based 3D accelerator due to reduced thermal resistance to heat sink. Furthermore, for near-memory computing with three-tier 3D systems, ReRAM based accelerator produces the lowest temperature whereas embedded DRAM (eDRAM) significantly increases the peak temperature.


2,6 - dimethylnaphthalene is an important start material for synthesis of poly ( ethylene - 2,6 - naphthalate) . In this paper, the possibility of preparation of 2,6 - dimethylnaphalene from toluene and 2 - metyl - 1,3 - butudiene is discussed and the analyzed results show, that only when the appropriate carbon atom in the carbochain of 2 - metyl - 1 ,3 - butudiene reacts with totlue, the title compound can be available in the end. Furthermore, various possible reaction pathways are predicted and their thermodynamic parameters such as standard molar enthalpy of reaction and standard equilibrium constant are calculated. The calculated results indicate that 2,6 - dimethylnaphalene may be prepared from toluene and 2 - metyl - 1,3 - butudiene.


Parasitic infestation is associated with an increase in the mast cell population of tissues. Heparin is released from the mast cell to activate lipoprotein lipase and may influence fat metabolism. Depletion of the mast cell population may be a characteristic of a parasitic free, atheroma prone 'Western' population.


Quantitave sampling on mussel beds attached on artificial substrates at three sites of Thermaikos Gulf, in summers and winters of two successive years, revealed the presence of 6600 amphipod individuals belonging to 17 species. The most dominant species were: Elasmopus rapax, Maera inaequipes and Corophiwn acutum. Significant differences in the abundances of amphipods and in diversity indices between the two seasons were found. the former increasing as the latter decreases in summer.


In this paper, presents design evaluation of Pneumatic Clutch Valve Unit of vehicle. Pneumatic Clutch Valve Unit of vehicle is designed in Valve_Body and Solenoid valve, Other parts. Catia program was used to design of Clutch Valve Unit. Ansys_Fluent program was used to CFD analysis of Clutch Valve Unit. Through this study, We were obtained optimum Pneumatic Clutch Valve Unit specifications. The current research will be a very useful tool in the near future for the Design Evaluation for the Pneumatic Clutch Actuator Unit.


The excellent therapeutic effect is reflected by long lasting and complete pain relief of xylocaine alone or preferably in combination with methyl prednisolone (Depo‐Medrol) in more than 100 cases of chronic tension headache. Which explains our belief regarding the pathophysiological mechanism of tension headache, which is an increased sensitivity of one or more of the sensory nerves of the scalp to noxious or even non‐noxious stimuli, so the sensory nerve(s) become vulnerable to any stimulus which simply results in functional disturbances of the nerve(s) which leads to exaggerated response to triggering factors, such as: stress & cold.


The total mineralization of formation water is 13 831 mg/L~89 445 mg/L in Upper Paleozoic of Hangjinqi area in north of Ordos basin,belong to the category of brine and bittern.Most of the formation water is CaCl2 with a pH value of 4.37~7.3,between strong acidity and alkalescence.According to the analysis of water salinity,pH value and ion concentration etc.,it was found that the characteristics of formation water have obvious difference in Boerjianghaizi fault zone and in the north and south area.In Boerjianghaizi fault zone,the water salinity is as high as 47 061 mg/L~89 445 mg/L,pH value is as low as 4.37~6,and Mg2+ concentration reaches to 7 024 mg / L.In the south of fracture zone,formation water anion is mostly Cl-and HCO3-,without SO42-.In the north of fracture zone,formation water contains SO42-,and the SO42-concentration increased distinctly from south to north.The active mechanism and geologic feature were studied synthetically in reference to the formation water genetic model of Davission.It was thought that formation water in Boerjianghaizi fault zone has a mixing formation,mainly by hydrothermal fluid activity in fault zone resulted from deep part meta-acid water of high temperature,high Mg2+ and hypersalinity admixture with formation water in Upper Paleozoic.Present measurement indicated that the thermal gradient in fault zone is the highest in the region,ranging from 2.72 ℃/hm to 2.9 ℃/hm.In the north of fault zone,thermal gradient is only 2.27 ℃/hm~2.36 ℃/hm,associated with infiltration and cooling of late surface water.Primary fluid-rock interaction outside fault zone is the albitization of plagioclase.The establishment of formation water fluid thread of Upper Paleozoic in basin provided evidence for the research of genesis of formation water.The relationship between variation of formation water and characteristics of hydrocarbon indicated that the activity of hydrothermal fluid was in favor of the maturity of hydrocarbon source rock.Increase of SO42-northward showed that it was affected by atmosphere fresh water,and the preservation condition was worsen gradually.


The proteinase‐activated receptor 1 (PAR‐1) plays a central role in melanoma progression and its expression level is believed to correlate with the degree of cancer invasiveness. Here, we show that PAR‐1 is post‐transcriptionally regulated by miR‐20b microRNA in human melanoma cells. PAR‐1 was found to be expressed in metastatic melanoma cells but was barely detectable in primary melanoma. By transducing primary melanoma cells with a lentivirus containing a 3′‐UTR construct of PAR‐1 mRNA, we could show that endogenous melanoma microRNAs interacted with PAR‐1 3′‐UTR and silenced a fused luciferase reporter. Transfection of an inhibitor against miR‐20b into primary melanoma cells reversed this process. Finally, transfection of miR‐20b mimic into metastatic melanoma cells caused downregulation of the luciferase reporter. We conclude that miR‐20b regulates expression of melanoma PAR‐1 receptor, which may explain the differential expression of PAR‐1 observed in human melanoma.


This paper describes a detection system of traffic sign for use in moving cars. Input image captured from color CCD camera is converted in HSV or RGB color space. In color space are done preprocessing actions, to determine the position of traffic signs. Image segment from this position is further tested for class of traffic sign, which means: features are extracted and used as input in to image classification system. Potential of this proposed detection system is discussed.


We present a Chinese word segmentation system submitted to the closed track of Sighan bakeoff 2005. Our segmenter was built using a conditional random field sequence model that provides a framework to use a large number of linguistic features such as character identity, morphological and character reduplication features. Because our morphological features were extracted from the training corpora automatically, our system was not biased toward any particular variety of Mandarin. Thus, our system does not overfit the variety of Mandarin most familiar to the system's designers. Our final system achieved a F-score of 0.947 (AS), 0.943 (HK), 0.950 (PK) and 0.964 (MSR).


On-chip picolitter scale micro syringe system by using electrostatically controlled linear actuator (ECLIA) was proposed and demonstrated previously. Parallel sliders of ECLIA can push and pull liquid in channels independently. The system achieved picoliter-scale liquid manipulation, however, the indirect drive through separating membrane caused a poor response. This paper reports an improved system from the aspect of controllability. The improved system directly manipulates liquid by sliders of ECLIA. The head of a slider is 340 mum x 200 mum at the end. 4 sliders are arranged to demonstrate parallel manipulation. A developed system shows 1.37 pl/step in fluidic delivery. Furthermore, integrated structure with sliders and channels will be also designed to demonstrate advantages of batch- fabrication.