The goal of this paper is to implement the design of a previously proposed inverted-pair EMI detector using a Monte-Carlo based simulation framework. The inverted-pair EMI detector can detect electromagnetic disturbances in a wired communication channel and generate a warning to the processing unit. The warning generated by the detector helps the system to follow a precautionary procedure, e.g. a safe-state operation or a re-transmission of data. In order to verify the theoretical results, the performance of the EMI detector is evaluated in a reverberation environment using a dedicated simulation framework. The simulation framework uses an efficient reciprocity-based algorithm to calculate voltages and currents induced due to Electro-Magnetic (EM) waves. These induced voltages and currents add up with the transmitted signal on the data transmission lines, disturbing the actual data. The inverted-pair EMI detector aims to identify these disturbances in the reverberation room environment, thereby confirming previously theoretically analysed results.


The unitary limit refers to a scattering problem at infinite scattering length where a scattering state becomes bound. Such a limit is experimentally accessible in systems of cold atoms at the vicinity of Feshbach resonances. In nuclear physics, a physical manifestation of the unitary limit is of interest both from the experimental challenge to measure such a limit in nuclei and from the theoretical aspects that accompany that limit such as conformal symmetry, a quantum critical point and the BCS-BEC crossover. In this talk the application of a symmetry-based approach to the unitary limit in collective states of heavy, even-even nuclei is presented that is performed by means of the Interacting Boson Model of nuclear structure in conjunction with the Feshbach formalism of nuclear reactions. The results of this application start from the determination of what is to be measured in the experiment for the examination of the unitary limit in collective nuclear states. That is the fluctuations of the cross-section of the A+2n compound nucleus. The primary theoretical result concerns the representations of conformal symmetry in A+2n compound nuclei via the fluctuations of cross sections.


Water transport in the Porous Transport Layer (PTL) plays an important role in the efficient operation of polymer electrolyte membrane fuel cells (PEMFC). Excessive water content as well as dry operating conditions are unfavorable for efficient and reliable operation of the fuel cell. The effect of thermal conductivity and porosity on water management are investigated by simulating two-phase flow in the PTL of the fuel cell using a network model. In the model, the PTL consists of a pore-phase and a solid-phase. Different models of the PTLs are generated using independent Weibull distributions for the pore-phase and the solid-phase. The specific arrangement of the pores and solid elements is varied to obtain different PTL realizations for the same Weibull parameters. The properties of PTL are varied by changing the porosity and thermal conductivity. The parameters affecting operating conditions include the temperature, relative humidity in the flow channel and voltage and current density. A parametric study of different solid-phase distributions of the PTL and its effect on thermal, vapor and liquid transport in the PTL under different operating conditions are discussed.Copyright © 2013 by ASME


Material and Method: This hospital based prospective case study was carried out at the department of Ophthalmology, Baqai Medical University Hospital, Karachi from August 2000 to January 2004. A total of 3195 patients of 40 years and above were examined on slit-lamp for evidence of PEX syndrome and glaucoma and those found to be having the disease were subjected to further thorough examination including visual acuity, Goldmann applanation tonometry, gonioscopy, slit lamp examination before and after dilatation of the pupil, fundus examination and visual field examination.


GRAPHICAL ABSTRACT Abstract A simple, novel, and an efficient synthesis of α-hydroxy phosphonates (3a–d) and phosphinates (5a–f) has been accomplished from febuxostat aldehyde (1) with various dialkylphosphites (2) and dialkylphosphinates (4) in the presence of 1, 4-dimethylpiperazine as a strong base with good to excellent yields (78%–95%) is reported. The structures of the title compounds were established by elemental analysis and spectral data (IR, 1H, 13C and 31P NMR, and LC-MS). All the title compounds (3a–d) and (5a–f) were tested for their antimicrobial and antioxidant activities. Bioassay results reveal that a few of the title compounds exhibited promising antimicrobial and antioxidant activities.


Numerical calculations based on the Ziman nearly free electron theory of the resistivity and thermopower of the noble metals are presented. The phase shifts of muffin-tin potentials are used to construct the t-matrix of a single scattering centre. Good agreement with experiment is achieved.


Objective To explore the diagnosis and treatment of rare and uncommon acute abdomen. Methods The clinical data of 8 cases with rare and uncommon acute abdomen in 5680 patients with acute abdomen in our hospital from 1992 to 2006 were analyzed retrospectively. Results 7 cases were cured clinically by operation, one dead because of postoperative respiration and circulation failure with improper operation in 8 cases with rare and uncommon acute abdomen. The rate of cure was 87.5%. Conclusion Thinking should be wide,physical examination should be all round,exploratory laparotomy should be careful in the diagnosis and treatment of acute abdomen. To improve level of the diagnosis and treatment, we should think of not only common cases but also rare and uncommon cases.


The University of Arizona is uniquely fortunate to include both the Optical Sciences Center and Steward Observatory, where a great deal of work has been done in the past and is continuing today in the areas of optical design, fabrication, and testing. These organizations, literally across the street from each other, have over the years cooperated on numerous telescope and related projects. Interferometry has played a key role in the fabrication of the optics for these projects and has been an area of constant development as requirements for these optics have become more stringent.


The ecological factor of seedling breeding of Rhododendron was studied with five species of wild Rhododendron in Dandong city as the materials. The influences of matrix,seed treatment,light condition,seedtime on the seed germination and emergence rate of Rhododendron were investigated. The results showed that best germination rate was gotten when the seed was treated with 50- 100 mg ·L- 1of GA before sowing and the seed was sowed in moss under full light. The germination rates of all species of wild Rhododendron were achieved when the seed was sowed in March except the species of Dianchuan Rhododendron.


Of the 150 working-age visually impaired adults in this study, 59 were in paid employment, 36 were either actively seeking employment or interested but not actively seeking it, and 55 were not interested in employment. Of the 59 who were employed, 22 were considered to be underemployed. The amount of usable vision, gender, and the presence of other disabling conditions were found to have significant affects on the rates of employment, unemployment, and labor force participation and some apparent affects on underemployment.


'Won' is a name for buildings attached to buddhist temples in the north-eastern Asian countries including China, Japan and South Korea. "Won's' had special functions of hospitality facility; particularly those in Korea which differed from those in China and Japan, in that they more actively participated in economic activities such as trade and finance. In fact, during the era of the Koryo Dynasty, Won's functioned not only as a place of religious hospitality but also the center for both transportation and business. Its origin starts from around 8th century AD, and it had flourished in the era of Koryo dynasty, between 10th and 14th century AD. Although it was a part of a temple facilty, its hospitality characteristics and functions were different from that of European monastic hospitality, more closely resembling functions of Caravanserais of the Silk Road. Concurrently, however, with the fall of Koryo Dynasty and the rise of Chosun dynasty, Won lost not only its religious character but also the function of business functions and lost its dynamism and became a part of 'totalitarian station system'(驛傳制), called as 'Yok-Won-Je'(驛院制). However 'Won' was a peculiar hospitality system of Korea, which experimented business complex hotels or accommodations 1000 years ago.


Abstract This paper analyzes empirically the distribution of unemployment durations in West Germany during the 1980s and 1990s. It therefore covers periods before and after the changes during the mid-1980s in the maximum entitlement periods for unemployment benefits for older unemployed. The analysis is based on the IAB employment subsample containing administrative data for about 500,000 individuals. Since these data only partly reveal the unemployment duration in an economic sense, we use a narrow and a wide proxy for unemployment. Our empirical analysis finds significant changes in the distribution of non-employment durations for older unemployed. At the same time, the distribution of unemployment durations between jobs remained unchanged after the reforms. Our findings clearly show that many firms and workers used the more beneficial laws as a part of early retirement packages. Surprisingly, for those workers who found and accepted a new job, we do not observe a prolongation of their search periods to a sizeable extent.


The helical sense of conducting polyaniline nanofibers was induced using chiral acid as dopant, which can be inversed through a copolymerization of aniline with N-methyl aniline. By delicately controlling the inversion driving force of steric hindrance, we successfully obtained "helical heterojunctions" composed of right- and left-handed helical structures in one helical nanofiber.


A thermodynamic analysis of the bending free energy of DNA, initiated previously, is extended. It was demonstrated that the ionic‐strength dependence of the persistence length of DNA in aqueous NaCl can be understood by postulating (1) a rigid‐rod 60 base‐pair unit and (2) a negative contribution from nonelectrostatic sources to the bending free energy of this unit. On electrostatic neutralization of the phosphate charge, the latter term alone survives, and bending becomes a spontaneous process. In this paper it is demonstrated from a theoretical analysis of the ionic‐strength dependence of the rate of denaturation of DNA that the above statements are restricted in their validity to radii of curvature greater than 170 Å; beyond this limit, the steeply rising repulsive energy of tightly packed atoms dominates the bending free energy. Therefore, spontaneous bending on charge neutralization proceeds up to, but not beyond, this barrier to curvature. It is noted that doughnut forms of DNA induced by binding of cationic spermidine, or mixtures of Mg2+ and polyamines are observed to possess maximum curvatures, corresponding to the radius of the "hole in the middle," in the range 1/150–1/200 Å.


Unlike most of his contemporary writers who evaded the military service during the American Civil war, Ambrose Bierce voluntarily enlisted and served in the Army as a Union solider for the entire period of the war. For the first time in the history of American literature, Bierce realistically describes the bloody battle like a photograph through most of his short stories on the war. Furthermore, Bierce's representative short story "Chickamauga" remarkably discloses the estranged world of the grotesque in which the ambivalence of life and death, innocence and experience, horror and laughter coexists. Transcending the bounds of periods and genres, "Chickamauga" has a great impact on lots of artists. This is manifested in a Received(January 10, 2018), Review Result(January 19, 2018) Accepted(March 9, 2018), Published(April 30, 2018) 1) Professor, 617-736 College of General Education, Silla Univ., Gwaebeop-dong, Sasang-gu, Busan, Korea. email: firstname.lastname@example.com 2)(Corresponding Author) Professor, 617-736 College of General Education, Silla Univ., Gwaebeop-dong, Sasang-gu, Busan, Korea. email: firstname.lastname@example.com A Comparative Study of Ambrose Bierce and Robert Enrico: The Grotesque in the Novel "Chickamauga" and the Film Chickamauga Copyright c 2018 HSST 914 superb short film entitled Chickamauga in 1962 created by a French film director Robert Enrico. It is important that this film strikingly transforms Bierce's estranged world of the grotesque reminiscent of the expressionist or surrealist painting, which provokes both horribleness and a bitter smile, into the visual representation. Enrico's film epitomizes the extension of verbal literacy as it eminently represents the essence of the grotesque in Bierce's "Chickamauga."


Based on the research into the community-based classroom teaching in the Damin School for the Mentally Retarded in Ningbo City,Zhejiang Province,this article discusses the theoretical basis and connotations of community-based classroom teaching in schools for the mentally retarded,the construction of the people-oriented community-based teaching system,the teaching model combining classroom teaching and the community,and the protection mechanism for classroom teaching in the community.


Background—Gradual telomere erosion eventually limits the replicative life span of somatic cells and is regarded as an ultimate tumour suppressor mechanism, eliminating cells that have accumulated genetic alterations. Telomerase, which has been found in over 85% of human cancers, elongates telomeres and may be required for tumorigenesis by the process of immortalisation. Malignant mesothelioma is an incurable malignancy with a poor prognosis. The disease becomes symptomatic decades after exposure to carcinogenic asbestos fibres, suggesting the long term survival of pre-malignant cell clones. This study investigated the presence of telomerase in pleural malignant mesothelioma, which may be the target for future anti-telo-


The Fluorinel and Storage (FAST) Dissolver built by Westinghouse Idaho Nuclear Co. uses a soluble boron compound for criticality prevention. To validate the criticality codes used by Westinghouse, Los Alamos National Laboratory (LANL) designed and performed a series of experiments intended to simulate the important neutronic characteristics of the FAST dissolver. For that purpose, a nickel-reflected solution assembly fueled with highly enriched uranyl-nitrate solution containing relatively high concentrations of boron was built and is described.


77 Background: [177Lu]Lu-PSMA (LuPSMA) is currently FDA-approved for use in the post-taxane, post-antiandrogen setting in pts with mCRPC. Little is known about the efficacy of treatment in pts with subsequent progression after LuPSMA. In this single-centre retrospective analysis, we evaluated efficacy of first subsequent therapy following LuPSMA. Methods: 234 mCRPC pts who received LuPSMA at the Peter MacCallum Cancer Centre from 2015-2022 were analysed. Pts were excluded if they did not receive any subsequent treatment (n=136), if they received the initial course of LuPSMA in combination with another therapy (n=10), or if insufficient follow-up data were available (n=15).Retreatment withLuPSMA was considered a subsequent line of therapy. Data collected included 50% PSA response rate (PSA-RR), PSA-progression free survival (PSA-PFS) and overall survival (OS). Survival outcomes were calculated using Kaplan-Meier analysis. Results: Of 73 evaluable pts, 32 were retreated with LuPSMA (median 2 cycles); and 41 commenced a new line of systemic therapy. In the LuPSMA retreatment group, the PSA-RR was 44%, median PSA-PFS was 3.8 months and median OS 14.8 months. In pts who changed to a new line of treatment, cabazitaxel was the most commonly prescribed therapy (n=25), followed by docetaxel (n=7), and single-agent carboplatin (n=4), in addition to carboplatin/etoposide, mitoxantrone, olaparib, capecitabine and a clinical trial (n=1 for each). PSA-RR was 12%, median PSA-PFS was 3.5 months and median OS 6.6 months. Conclusions: This retrospective data demonstrates that retreatment with LuPSMA is associated with benefit, though this is reduced compared to initial treatment. In our cohort of pts who commenced a new line of therapy, most were not suitable for retreatment with LuPSMA, potentially reflecting de-differentiated and more aggressive disease phenotypes. In those not suitable for LuPSMA retreatment, other systemic therapy appears to have limited benefit, highlighting the lack of effective salvage options and raising questions about treatment sequencing. [Table: see text]


Hyperbolic radio-location systems possess intrinsic uncertainty that depends on the sensor's geometry and the modulation's time resolution. In this paper the best locations for the receivers to minimize the uncertainty in 2-dimensional (2-D) and 3-dimensional (3-D) models for indoor systems are found. For this purpose the minimum number of receivers with clear line-of-sight (LOS) to the emitter, required for locating a source, are three and four in 2-D and 3-D respectively. For 2-D, a triangular area and for 3-D a tetrahedron volume are considered the building blocks that are used to extend results to more arbitrarily shaped areas. The criteria for minimization of location uncertainty is uncertainty area or the largest diagonal in 2-D and the multiplication of line-of-position (LOP) errors in 3-D. Finally a theorem is given for the number of sensors that is sufficient to cover the entire area in 2-D and 3-D cases.


Objective To examine the relationship between AsAb in sera and semen and other indexes of semen of male infertiltity,and to find out the correlation between AsAb and infertility and mechanism of infertility.Methods AsAb in sera and semen and other indexes of semen from 127 cases of male infertile patients and 86 normal persons were measured with ELISA.Results The positive rate of AsAb in the sera of in- fertile patients(29.9%)was significantly higher than that of normal controles(4.7%),P0.05.The change of AsAb lev- el could cause a remarkable decrease of sperm activity.There was a significant positive correlation(P0.05).Conclusion AsAb is closely related to male infertility,and may lead to a remarkable decrease of sperm activity,but does not signifi- cantly affect sperm density and liquidization.


An unusual abundance of contemporary sources illuminates the 1330s: the traveler Ibn Batuta, the statesman Al-Umari, al-Urtyan of Sivrihisar, and Balban the Genoese—all writing in Arabic—the Turkish epic about Umur of Aydın and treaties between the Venetians and Menteşe. Ibn Battuta in particular gives an eye-witness account of the emirates and their rulers. The sources illustrate the wealth of maritime Aydın and Menteşe as well as Germiyan and narrate the spectacular career of Umur and the rising power of Orhan who, however, was paying tribute to the Mongols The chapter describes the emirates along with the Byzantine outpost of Philadelphia. It integrates the coins into the narrative.


This work explores how contextual information and human intention affect the motion prediction of humans during a handover operation with a social robot. By classifying human intention in four different classes, we developed a model able to generate a different motion for each intention class. Furthermore, the model uses a multi-headed attention architecture to add contextual information to the pipeline, such as the position of the robot end effector (REE) or the position of obstacles in the interaction scene. We generate predictions up to two and half seconds in the future given an input sequence of one second containing the previous motion of the human. The results show an improvement of the prediction accuracy, both for the full skeleton prediction and the human hand used for the delivery. The model also allows to generate different sequences with the desired human intention.


BACKGROUND
Machine perfusion was found an effective tool to recover organ grafts from ischemic insults during preservation. It could be observed that organ integrity is significantly affected by abrupt temperature shifts during hypothermic storage and implantation periods. Studies showed that a gentle and controlled rise of the temperature during oxygenated machine perfusion prior to implantation can protect the tissue from reperfusion injury. Now, the possible role of temperature kinetics upon retrieval of the graft and prior to later cold storage should be investigated.

METHODS
Rat livers were retrieved after cardiac arrest and subjected to a brief ex situ machine perfusion with either hypothermic resuscitation (HR) at 8°C, near-normothermic resuscitation (NR) at 30°C or progressive resuscitation with lowering the temperature in a controlled fashion from 30°C to 8°C (PR). After cold storage (CS), liver functional parameters were evaluated by an established ex vivo reperfusion system.

RESULTS
NR and PR resulted in significantly lower release of hepatic enzymes and less production of TNF upon reperfusion compared to CS while HR had a far less protective effect. An increase in bile production was only observed in the PR group, which also significantly increased the recovery of tissue ATP, the amount of which was, however, nearly paralleled by the NR protocol.

CONCLUSION
Within the limitations of this model, it seems that normothermic recirculation appears to be a superior approach for the restitution of warm-ischemically injured liver grafts than immediate hypothermic machine perfusion.


BACKGROUND Portal vein aneurysm (PVA) is an uncommon vascular dilatation, showing no clear trend in sex or age predominance. Due to the low number of published cases and the lack of management guidelines, treatment of this condition remains a clinical challenge. CASE SUMMARY We present three cases of asymptomatic PVA; the first and second involve an extrahepatic manifestation, of 48 mm and 42.3 mm diameter respectively, and the third involves an intrahepatic PVA of 27 mm. All were diagnosed incidentally during routine check-up, upon ultrasonography scan. Since all patients were asymptomatic, a conservative treatment strategy was chosen. Follow-up imaging demonstrated no progression in the aneurysm dimension for any case. CONCLUSION As PVA remains asymptomatic in many cases, recognition of its imaging features is key to favourable outcomes.


High temperature properties of binary and ternary cobalt-refractory-metal alloys, with special attention to carbon and zirconium addition effects on rupture life of the alloys


Objective
To investigate the status of palliative care knowledge and attitude of nurses in primary hospitals, and analyze the influencing factors, so as to provide bases and decisions for the further popularization of palliative care.

Methods
Totally 362 nurses from primary hospitals were selected as this research object, and their knowledge and attitude of palliative care were investigated by self-designed questionnaires.

Results
The standard score of palliative care of nurses from primary hospitals was (54.28±14.06), 123 nurses were qualified (33.98%), and 26 nurses were good (7.18%); the standard score of caring attitude was (82.76±9.24). The influencing factors of palliative care knowledge and caring attitude included religion, department, working years and title(β′=0.308, 0.263, 0.121, 0.104).

Conclusions
The attitude of nurses in primary hospitals is positive, but their related knowledge of palliative care is incomplete, especially the knowledge of spiritual care. Targeted training can improve the knowledge of palliative care of nurses, and popularizing it successfully.

Key words:
Nurses; Knowledge; Attitude; Palliative care; Survey


Bachelor thesis focuses on opinions on the lenitive care and euthanasia. This work consists of a theoretical part and practical part. The theoretical part is focused on a thanatology, dying, dead, lenitive care, hospice care and euthanasia. These terms are characterised, described and they are viewed on from various viewing angles. In the practical part I am presenting the result of my quantitative research. Its goal was to find out the opinions and approaches of students of the Tomas Bata University in Zlin to euthanasia and lenitive care.


The usage of PCR-based or NGS-based liquid biopsy assays for circulating tumor DNA (ctDNA) detection is growing rapidly in clinical labs. However, inconsistent results are often observed especially when assays from different developers are compared. One reason for the discrepancy may be a lack of cost-effective evaluation samples based on true human plasma without which the performance parameters such as Limit of Detection (LOD) are often measured incorrectly. To confirm the necessity of using human plasma as sample matrix, the following study was conducted. We have developed a proprietary technology that specifically removes DNA from plasma without affecting the composition of the plasma. This overcomes the scarcity of patient sample and uncertainty of endogenous cfDNA from an unknown patient sample. Based on DNA-depleted plasma, patient-like ctDNA validation samples were made by quantitatively spiking in a ctDNA fragment, BRAF V600E, together with wild type genomic DNA fragments. Linearity and sensitivity of allele frequency (AF%) determination were performed in qPCR assay. Matrix effect on LOD measurement was studied among ctDNAs made with TE buffer, BSA-based "synthetic plasma," and human plasma at 10ng/ml pre-spiked cfDNA level in each matrix. The effect of different extraction methods on LOD measurement was compared using three different commercially available cfDNA extraction kits. Characterization of DNA-depleted plasma, including measurement of protein, lipids, and exosome content showed comparable results before and after depletion. cfDNAs spiked into the plasma were stable for at least 135 days at 2-8 °C. Number of copies of DNAs was recovered linearly. Replicate standard deviations (SD) of measured ctDNAs spiked in DNA-depleted plasma were equivalent to those spiked in real patient sample but significantly higher than those spiked in "synthetic plasma" or TE buffer. For samples in the same matrix, SDs of AF% dropped as the concentration increased. The drop was especially sharp at levels near the LOD. The LOD was much higher for samples in plasma (AF 1.83%) than for samples in buffer (AF 0.29%). For a positive sample with AF at 0.5%, the buffer-based was detected 100% of the time, whereas the true positive rate for plasma-based was only 69%. Significant difference in ctDNA recovery, replicate SD, and LOD were observed with different extraction methods. The data demonstrated that plasma factors influence ctDNA assay through cfDNA extraction. Validation samples and quality controls need to be made with human plasma as the appropriate matrix to ensure correct measurement of assay variation and sensitivity. Citation Format: YABIN LU, Kara Ooi, Keegan Shi, Emily Chan. Improving measurement of assay variation and Limit of Detection (LOD) of ctDNA assay by using validation samples contrived with DNA-free human plasma [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 4272.


This paper has examined critically these challenges on the Nigerian National Grid and has proposed options of overcoming them using NEPLAN which is a very user friendly planning and information system simulation software for electrical power systems analysis such as Load Flow, Fault level calculations, Transient stability, Voltage stability, and Motor starting.


This paper describes a circuit, which generates temperature-independent bias currents. In this paper, low-temperature coefficient reference is presented. The circuit is firstly employed to generate a current reference with temperature compensation, then combining the opposite characteristic curve current reference to minimize the variation of temperature. The proposed circuit has been design by a 0.18μm CMOS technology process and using computer simulation to evaluate the thermal drift of the reference current. This current reference is used to provide a stable current for a current controlled oscillator(CCO). The proposed CCO achieves temperature coefficients of 22.3 ppm/°C in the temperature range between −25 and 75°C.


Open source has become the de facto community process for the Internet. The success of this process has primarily been in software development, starting with its roots in Linux (http://www.linux.org/), and has spread to hundreds of diverse projects ranging from designing a better intravenous system for third world patients (http://www.thinkcycle.org/), improving cooking recipes (http://www.ibiblio.org/ oscookbook/), solving crime (http://doenetwork.org/), calculating Pi (http://projectpi.sourceforge.net/), and writing textbooks for academia (http://otp.inlimine.org/.)


To the editor: In 1987 Dr von Wussow and colleagues reported the occurrence of neutralizing antibodies to recombinant interferon-alpha,, (rIFN-a,,) in 25 % of IFNtreated chronic myelogenous leukemia patients (1). The observation has later been confirmed by others (2,3). IFN antibodies may develop also upon therapy with rIFN-a,b (15%) (4) and lymphoblastoid IFN (4%) (5). Dianzani et al. (6) reported that among 354 patients treated with rIFN-a,, 17 % had neutralizing antibodies, as had 6% of those treated with rIFN-a,,. A higher number of patients had IFN-binding antibodies. Induction of IFN antibodies may render the patients refractory to further IFN therapy (1, 7). Thus, it should be of clinical importance to prevent the emergence of IFN antibodies. Here we report the incidence of IFN-binding antibodies in multiple myeloma (MM) patients treated with natural (leukocyte-derived) IFN-a as primary therapy . 44 patients with MM stages I1 or I11 were studied. The patients received melphalan/prednisone repeated every 6th week together with 7 x lo6 units (U)/m2 of natural IFN-a (Finnferon alpha, Red Cross Transfusion Service, Helsinki, Finland) S.C. for 5 consecutive days repeated every 3rd wk (8). At the time of clinical response (defined as a 50% reduction of the pretreatment serum M component concentration) the IFN dosage was changed to 3 x lo6 U daily 3 d a week continuously. Various numbers of treatment cycles were given during the induction period. At the time of test, 15 patients received induction therapy, 24 patients were on the continuous low-dose IFN schedule and in 5 patients IFN had been withdrawn due to side-effects or progression. The test was performed after a median IFN treatment period of 17 (3-5 1) months. The median cumulative dose of IFN was 846 (1902964) x lo6 U. Serum samples were collected between 72 h and 4 months after the last IFN administration. The presence of IFN-binding antibodies was analyzed by ELISA (BioNative, Ume$ Sweden). Briefly, serum samples were added to wells in micro-ELISA lates recoated with human leukocyte IFN immoklizedty goat polyclonal anti-IFN antibodies. After incubation for 1 h at room temperature (RT), the wells were washed and an alkaline phosphataseconjugated goat anti-human IgG was added for 2 h at RT. After washing x 4, substrate was added and absorbance was read at 405 nm after optimal color development. The absorbance values were corrected for unspecific binding by subtraction of the absorbance values in parallel control wells not coated with IFN. The accuracy of the ELISA test was confirmed by reference sera kindly provided by Drs P. von Wussow, Hannover, Germany, E. Lundgren, Ume$ Sweden and Hoffman-La Roche, Nutley, New Jersey, USA (data not shown). IFN-binding antibodies were not detected in any of the sera of the 44 MM patients, despite repeated S.C. injections and comparatively high cumulative doses of IFN. In 3 patients, IFN was withdrawn 1-4 months before test due to progression of the disease. The treatment failure on IFN in those patients was probably not due to the occurrence of IFN antibodies. MM patients have an impaired humoral immunity. It cannot be excluded that the absence of IFN antibodies in the present study might be due to the inability of the patients to mount an anti-IFN immune response. However, we do not believe that this is the case since IFN-binding antibodies have been detected in 5-7% of MM patients treated with recombinant IFN (9, 10). It is concluded that antibodies against natural IFN-a used for therapy might appear in a very low frequency in MM patients. Similar results have been seen in patients with neuroendocrine tumors treated with natural IFN-a (K. Oberg, pers. comm.). Although a proportion of patients with neutralizing antibodies to rIFN-a may respond to therapy with natural IFN-a, there are those who do not respond. Thus, considering the possibility of developing antibodies to therapeutically administered IFN and thereby a subsequent possible inhibition of the antitumor activity, natural IFN-a may be preferable from this point of view.


A method of measuring the sphere equivalent hydrodynamic radius in highly concentrated suspensions is reported. Results showing the system to be concentration independent are given. The effects of polarization and the use of high birefringence fibers are discussed and shown to be important. The possibility of independence to fluid flow and the monitoring of the enhanced backscatter cone to given information on structure are considered. The equipment allows the use of a dip in probe and laser powers of only 1 mW are required.


The nature and source of the detergent substances in raw wool were studied. They were found to consist of fatty acids and acidic low polyesters and were not obtained from suint, the product of the sudoriferous glands.


Analysis of the agronomic performance of different fertilizer regimes in Lettuce production was conducted over a period of three months (November to February, 2014) in Valley View University Techiman Campus farm in Brong-Ahafo, Ghana. Eight (8) different treatments of fertilizer regimes were used for the study. These were; Poultry Manure only, Quarry Dust only, NPK only, Poultry Manure and Quarry Dust only, NPK and Quarry Dust only, NPK and Poultry Manure only, NPK, Quarry Dust and Poultry Manure only and no fertilizer as a control. The experimental design used was Randomized Complete Block Design. Eden variety was used in this experiment. Eden variety grown under Poultry Manure recorded the highest height of 15.1cm whilst that grown under NPK only recorded the least height of 13.4cm on the 7th week at a p value of < 0.05 significant difference. Meanwhile, there was no significant difference (p < 0.05) in the leaf area and the number of leaves after the various treatments of fertilizer regime from the second to the seventh week after planting. Keywords: Analysis, Agronomic, Fertilizer regimes, Eden variety


Ethiopia has substantial potential in beekeeping with rich flora, proper ecological conditions and existence of large bee colonies. However, modern beekeeping in study area is still faced with challenges in respect to lack of bee management skill, colony absconding and low honey production. The study was conducted in Jimma Zone where modern beekeeping has been practiced since 40 years. For the study three districts (Kersa, Goma and Gera) were purposively selected depending upon the existence of large number of modern beekeeping. A total of 75 beekeepers engaged in modern beekeeping were contacted and interviewed. Visual assessment of apiaries and internal inspection of suspected colonies were carried out to harmonize the relevant information noted by respondents. Interview on beekeepers characteristics, seasonal bee management practices of modern beekeeping, bee forage flowering seasons, bee management constraints and honey production were collected and analyzed. The result revealed that 62.7% modern beekeeping in the study area is based on inappropriate colony management practices and characterised predominately by high absconding and low honey yield despite the abundant bee forage potential in the study areas. Inappropriate skill bee management practices, colony absconding, poor design of modern beehives, low honey yield and bee pests are the main problems that impede the full use of apiculture resources in the study area. Interventions in modern beekeeping should be focused on empowering beekeepers with skills through ensuring availability of improved beekeeping technologies with standard seasonal bee management practices should be strengthened.


When adults are vulnerable due to advanced age and frailty, disease, learning disabilities, dementia, sensory loss (e.g., blind), physical handicap, or mental illness (e.g., schizophrenia), they may become more vulnerable to abuse. As the aging population continues to grow, the issue of adult abuse, especially of the elderly, will parallel this growth. In fact, according to Pritchard, approximately 68% of adult abuse victims occur in older adults. Fortunately, many are not only broaching this topic but providing didactic materials to disseminate this information as in this book. Pritchard discusses this topic while providing a historical look at adult abuse stemming from child abuse and elder abuse. She continues by presenting how legislation developed over decades, which eventually led to the protection of vulnerable adults. She also covers chapter by chapter the issues endemic to this topic including how to confront suspicion of abuse, types of abuse (e.g., sexual, physical, emotional, financial, neglect), documentation of the abuse, coping with the abuse both from the client's and service provider's perspective, developing an inquiry into allegations of abuse, developing treatment plans, and following up with the client. What is probably the most helpful point of the book is the establishment of a sense of protocol in detecting, tracking and monitoring, and intervening in abusive situations. In fact, Pritchard is very keen in demonstrating the thin line between which behaviors constitute abuse and which behaviors may be simply considered inconsiderate or dysfunction; this point is especially made poignant by the scenarios she provides. The information provided is in many ways common sense, but given the emotional volatility of dealing


The paper discusses the issue of disturbance atten-uation in the linear tracking control problem. The disturbances are assumed to be bounded and the invariant ellipsoid method of controller design is adopted. The problem is posed in two versions depending on the measurability of the state vector. For the state-feedback problem the previously unknown necessary and sufficient conditions are given and the exact procedure for calculating the controller parameters is presented. For the output-feedback problem the sufficient conditions and the approximate procedure for calculating the controller parame-ters are outlined. The results are validated by the numerical experiments.


Mortar prisms, made with pure cement or cement plus 30% mass of limestone powder, were stored in 2% magnesium sulfate solution at (5±1) ℃, and the strength and external appearances were tested at different storage days. The mineral components and microstructure of samples were examined. The results show that the addition of limestone powder leads to the transformation of monosulfoaluminate to monocarboaluminate with a better stablility during the cement hydration period. And the limestone mortar has a higher compactness than the pure cement mortar due to the limestone powder's physical filling action. The limestone mortar shows a better erosion resistance than the pure cement mortar when exposed to sulfate solution at lower temperature for a short-term time. Sulfate attack on the pure cement mortar at lower temperature leads to formation of a mass of gypsum and ettringite. Besides gypsum and ettringite, however, a little thaumasite forms and the cement hydrate CSH gel is also eroded in the limestone mortar after 210 d of exposure to sulfate solution at lower temperature.


Specifically, based on the observation that a response is always preceded by a request in multi-processor SoCs, this letter proposes a novel deadlock-free XY-YX router for on-chip network performance improvement. In order to avoid deadlock, we add additional physical channels in the horizontal direction and optimize the priority of output channel allocation. Simulation results show the enhancement in the throughput of an NoC.


FIELD: machine building. SUBSTANCE: wind turbine capacity improvement system includes injection devices of air as the first fluid medium to the second fluid medium flow coming onto the turbine. The above air injection devices can perform air injection at high speed in turbine blade direction. EFFECT: improvement of wind turbine capacity. 32 cl, 8 dwg


Drought assessment and monitoring is very essential in identifying climate and water supply trends and thus to detect the probability of occurrence and the anticipated severity of drought. Drought occurs when precipitation is lower than normal. When this phenomenon extends over longer period of time, precipitation is inadequate to demand of human activities. This paper includes developing a methodology to assess drought severity and monitoring of the study area. Drought originates from a deficiency of precipitation over a given period of time: short time scales (months) characterize meteorological drought, while longer time scales (years) hydrological drought. A useful index for drought monitoring based only on monthly precipitation data is the Standardized Precipitation Index (SPI). It has been proposed to monitor dryness and wetness on multiple time scales. The present situation examines the SPI drought index in application for the Vallabh Vidyanagar Station and it is evaluated accordingly by historical precipitation data (1969-2006) for meteorological station. From the result, the worst drought years of 1974, 1986 and 1987 in the Vallabh Vidyanagar station indicate severe dryness and hence, the irrigation requirement can be evaluated on the rainfall deficits & its severity for the given years. SPI Index is a useful tool to assess the severity of drought for the study area.


A new statistical permutation analysis method is presented in this paper to efficiently and accurately localize regionally specific shape differences between groups of 3D biomedical images. It can improve the system's efficiency by approximating the permutation distribution of the test statistic with Pearson distribution series. This procedure involves the calculation of the first four moments of the permutation distribution, which are derived theoretically and analytically without any permutation. Furthermore, bioequivalence testing aims for practical significances between the two groups that are statistically significant with the shape differences larger than a desired threshold. Experimental results based on both classical and bioequivalence hypothesis tests using simulated data and real biomedical images are presented to demonstrate the advantages of the proposed approach.


Background: The prevention and care of foot problems in diabetes begins with a risk classification. Today, the prosthetists and orthotists (CPO) and other health care professionals assess the risk ...


The main research objective is to structure actions from physical culture, in order to prevent obesity in adults from 30 to 45 years old from the Popular Conseil


Short‐term memory binding (STMB) tests assess conjunctive binding, in which participants should remember the integration of features, such as shapes (or objects) and colors, forming a unique representation in memory. In this study, we investigated two STMB paradigms: change detection (CD) and free recall (FR).


The project develops and investigates multimedia cases for the
professional development of prospective teachers in elementary science
education. In the Netherlands, prospective teachers receive their initial higher education at teacher education colleges. In a four year course of study they are prepared to teach all subjects in elementary schools in all grades. Student teaching is incorporated into the program from year one. Future teachers are also encouraged to take responsibility for their learning processes (self-directed learning). There is a quest for a better balance between theory and practice in the program. The aim of the study is to examine how multimedia cases can contribute to establish a meaningful bridge between theory and practice.


Production practices of IF (interstitial free) steel grades intended for the most qualitatively demanding automotive applications calls for their continuous optimization. Precise control of steelmaking operation conditions leads to a minimization of clogging issues during their casting, but is also related to surface quality imperfections of finished material. With the aim to study the impact of RH degasser practices on cleanliness of the IF steel grades, the influence of heat chemical reheating was verified. While detailed analyses confirmed overall worse results and a higher presence of specific nonmetallic particles on steel samples collected from such treated heats, the limited reheating practice did not seem detrimental. Details below.


This paper designed an accurate and highly linear Voltage control oscillator, analog to digital converter using asynchronous sigma delta modulator in 45nm CMOS technology using Mentor Graphics Tanner EDA 16.3 tool is done. The proposed architecture comprise of Schmitt trigger and passive ASDM. Result proved that VCO frequency error is below 0.10%.while consuming 1.25mW power from a 0.8V supply.


Aims and Objectives – An Interventional study was designed to assess knowledge, attitude, and practices of gynaecologists practicing in Faridabad regarding Oral health care in expectant mothers and newborns. Materials and Methods - They were assessed using a 32 item validated self-administered questionnaire including demographic information and questions about knowledge, attitude and practice. Results - Data analysis was conducted using SPSS software (version 21) and Chi-square, 103 gynaecologists participated in the study and showed significant results with P value less than .05. Oral health manual was distributed among the gynaecologists, questionnaire was refilled and reassessment was done. It showed highly statistically significant results with p value = .0065. has shown improvement of their KAP score from 65.1750 to 81.6643. Conclusion - Thus it can be concluded that a comprehensive oral health program with the hand in hand of gynaecologists and dental specialist, is possible and has the potential to establish attitudes about the importance of maintaining optimum oral health of expectant mothers.
Keywords – Expectant mothers,  multiprofessional approach, newborn, oral Health manual.
Source of support – Nil
Conflict of interest – None
Ethical clearance - Approved


Before we begin, please take another look at the title; in particular, please notice that, open-ended and swollen though it is, it manages to avoid three words, one big, one mid-sized, and, in the most important side-step of all, a potent little article. The title avoids prolegomenon (the big word) and towards (the mid-sized word), because both terms are far more hesitant than we need be about rhetorical investigations of science. Although the field is rather new, it has proven remarkably successful, and there are abundant signs of a healthy future. As for the stout little article, the epigrams should indicate that it is missing because neither rhetoric nor science is stable enough to bear the immense burden of specificity that the definite article brings with it. Certainly there is no such thing as the rhetoric of science. But there is, carefully denuded of specificity, rhetoric of science. In fragmented form, it goes back as long as the two fields have existed, and it makes various appearances throughout the history of each. Aristotle, for instance, was a seminal contributor to both fields, and he occasionally speaks about them in the same breath-as when he says that dialectic and rhetoric are employed by the sciences, but are not sciences themselves (Rhetoric 1359b). Bacon's many writings on induction include a great deal of rhetorical and scientific commentary in concert, such as his discussion of invention in science and rhetoric (Advancement, XIII). And Priestley's Course of Lectures on Oratory and Criticism contains a wide range of rhetorical advice directed explicitly at his fellow scientists, like Lecture IX on the analytic method. Still, the development of a specific genre of rhetorical analysis directed at scientific discourse is a quite recent phenomenon, only now beginning to flower. The first few steps of the new genre were rather hesitant. Rhetoric is, after all, a shabby little weasel word in most circles, and science is a god-term; putting the two words together, only a slim little preposition between them, was not an act for the faint of pen or keyboard. Fortunately, scholars in other fields did most of the groundwork for us. Polanyi argued that sciences are knowledge-


Abstract This paper presents reduction of ZnO in EPDM formulations and its influence on efficiency of cable isolation by measuring cure behavior, electrical and mechanical properties before and after ageing. These experiments were performed on EPDM formulations by changing three key variables in formulation (concentration of ZnO, type of peroxide and content of ethylene in EPDM). The rheological characterization showed that replacing ZnO in EPDM with proper ethylene content (75 %) with the lower content of ZnO (5 phr) in the recipes, resulted in lower cure time and higher scorch time and higher crosslinking density, which was further supported by Fourier transform infrared spectroscopy (FTIR). Mechanical properties before aging (elongation at break, tensile strength, and hardness) are greater with smaller content of ZnO. The value of percentage change of the properties after aging at 135 °C for 7 days, indicates that recipe D (Perkadox 14/40 (Di (tert-butyl peroxy isopropyl) benzene (DTBPIB)) peroxide cured EPDM has the best performance at tensile strength, and elongation at break. What is more, recipe D, containing 5 phr of ZnO exhibits the desired electrical performance. The paper provides sufficient experimental background to indentify the key physical aspects associated with each of the instabilities that occur at higher amounts of ZnO in formulation, and this in turns provides insight into different occurrences of each instability and how they can be minimized by reduction of ZnO in EPDM mixture.


Fermenting ratafia.with Black Nightshade fruit,the honey,the white granulated sugar,ratafia yeast and active dry yeast,by optimum seeked process conditions,determined single factor condition,designed orthogonal layout.The favoured fermentation conditions are determined as follows:Sugar content 17%;Fermentation temperature 26℃;The ratio of the ratafia yeast to the active dry yeast is 3:1,yeast addition 1.3%;Fermenting time 5d.Fermenting black nightshade ratafia luster light yellow,wine taste fragrant,the feeling in the mouth is mellow.Total sugar content 8%~10%;alcohol content 8.5%;pH is 4.1 to 4.4.


This paper extends the usual regression analysis to include the partition of the variance to examine the possible secondary and higher order impact of policy variables in a policy impact model. The federal Medicaid program is analyzed using the methodology to assess the impact of the policy variable-differential federal matching ratio-on the per capita expenditure from state and local sources. Our result shows that the policy is ineffectual on its own but modestly effective with others when all important factors are considered simultaneously.


Using a sample of 291 Black women and a longitudinal study, we explore how general strain theory can broaden our understanding of Black women's alcohol use and intimate partner violence (IPV) perpetration. Results demonstrated that racial discrimination, past IPV and sexual victimization, and family member's victimization heightened depression, which increased heavy alcohol use. Discrimination and family victimization also elevated anger, leading to greater IPV perpetration. Results further revealed that depression and anger interacted to influence IPV. Researchers, practitioners, and policymakers must continue to pursue culturally sensitive practices to effectively address this unique constellation of strains and advocate for the needs of Black women.


Using the GPS carrier phase measurement,the relative distance between the two carriers can be surveyed accurately. The kernel problem is the resolve of the integer ambiguity. Through the dual frequences data, the speed of the resolve can be improved. Based on the derivation of ambiguity combination formula, this paper introduces one method which can resolve ambiguity rapidly and exactly using dual frequence GPS receiver. It is proved that this method is verified by experiments.


The short-tailed vole, Microtus agrestis (L.), is found primarily in grassland, where it feeds chiefly on the green leaves and stems of various grasses (Godfrey 1953; Hansson 1971). Its population dynamics have been studied in detail in Britain by Chitty and his co-workers (Chitty 1952; Godfrey 1955; Chitty & Chitty 1962a; Chitty & Phipps 1966) and quantitative estimates have been made of its food supply (Chitty, Pimentel & Krebs 1968; W. N. Charles unpublished). Hitherto, however, little attention has been paid to the qualitative changes which occur during each year in the various grasses eaten by Microtus. This paper presents measurements of the pepsin-soluble content of several grasses at different times of year, in parallel with changes in weight, body composition and breeding condition of voles from isolated populations in two types of habitat-ungrazed limestone grassland and a young plantation. It will be shown that grasses have maximum pepsin solubility for only a short period in the year, and that most growth and reproduction of M. agrestis occurs outside this period; that the pepsin solubility of the grasses has little direct effect on the timing of changes in weight of different body components (except that the spring weight increase in males coincides with the spring flush of grass), and that in the area studied Microtus carries no appreciable energy reserve at any time of year.


– This document describes the information for authors such as paper submission and the style of manuscript. Only PDF manuscripts are acceptable. The PDF manuscripts should be uploaded on the conference homepage. This document is a template file for a paper, although it is not necessary to strictly follow this format. 1 Manuscript Submission Prepare your manuscript in PDF and upload on the conference website 1) Submission deadline is Sep. Download rengo2014-en.zip for pLaTeX2.09 or pLa-TeX2e, uncompress it and edit sample-en.tex. Follow style in rengo2015-en.pdf for other software. Papers must be 2 pages minimum and 8 pages maximum in A4 size (US letter size is not allowed). Maximum file size allowed is 2MB. 3.1 Format Top, bottom, left and right margins are 20 mm 27 mm20 mm20 mm, respectively, which provide 250 mm × 170 mm space for your document. Character size should be as follows; paper title: 16 point, author names and affiliations: 12 point, chapter title: 11 point, section title: 10 point, and main body: 10 point. Papers should be prepared in the following order: • Paper title • Author names and affiliationsPresenter should be marked with an asterisk) • Abstract100 words • Keywords • Main body and references 3.2 Figures and Tables Figures and tables should be numbered as Fig. X and Table X as shown in Fig. 1. Use terms " Fig. " and " Table " to refer to figures and tables. Characters in figures and tables should be adequate size. Figures should be of sufficient quality for publication (300 dpi or higher is recommended). 3.3 References The following format should be used for references: (a) Journal papers No.) authors, paper title, journal title, volume bold-number, first page/last page (year) (b) Books No.) authors, book title, first page/last page, publisher (year) 0 1 2 3


DEAR EDITOR, A 33-year-old farmer presented with bullae and erosions for one month (a, b). Multiple black fly bites presenting as healing pinpoint haemorrhagic vesicles were identified (c). Black fly specimens, locally known as 'borrachudos', were brought in by the patient and were identified as Simulium pertinax (d), a highly anthropophilic species widespread near Brazilian highland rivers with high water pollution and environmental degradation. Indirect immunofluorescence showed IgG around keratinocytes (e). Immunoblotting identified antibodies against desmogleins 1 and 3, and against Simulium nigrimanum saliva (f, g). Exposure to black fly antigens may trigger IgG4 autoantibody formation in predisposed individuals.


Chinese families investing in education for their children has prompted an increasing number of students to study abroad. Sweden is becoming one of the destinations that attract a large number of C ...


In order to realize real-time online monitoring of the wastewater source enterprise,manage and issue its information,this paper comprehensively used automatic control,embedded data acquisition and transmission,distributed computing and data processing,geographic information system,etc.to develop automatic monitoring system of the wastewater source in Shandong Province.This system incorporates the automatic monitoring information acquisition,transmission and daily work as an organic whole.The system realizes not only the continuous online monitoring of wastewater source enterprise,but also the deep excavation and utilization to monitoring information.It provides the scientific and objective basis for energy saving,consumption reduction,carbon emission reduction,total amount control and other environmental management work,and meets the requirements of environment management and related departments to wastewater source management.


This paper presents a three-dimensional (3D) multi-physics finite element model (FEM) to predict the fatigue life of a laser welded lap joint of dual phase (DP) 980 steel sheets based upon the level of residual stress. A FEM-based thermal analysis is first performed to numerically predict the welding-induced temperature field combined with the corresponding experimental verification. The temperature histories are then loaded into the mechanical model as thermal loading to numerically calculate the evolution curves of thermally induced stress in order to calculate the level of residual stresses after cooling to room temperature. In order to calculate the equivalent fatigue strength in the laser-welded lap joint, the resultant multi-axial stress (including the induced residual stress (RS) result) is loaded into the equivalent uni-axial stress equation via the Sine Method (SM) in order to achieve the stress curve as a function of the loading cycles. A series of fatigue tests of lap joints are also performed in order to achieve the S-N curves, from which an empirical function between the alternating stress and loading cycle is derived in order to predict the fatigue life of the DP980 lap joint. Finally, the maximum fatigue strength can be predicted numerically through the proposed FEM instead of using experimental trials. The numerical results show that a greater temperature gradient and residual stress are mainly located within the fusion zone (FZ) and close to the heat affected zone (HAZ). The residual stress plays an important role in deciding the final fatigue strength and failure of the DP980 lap joint. An X-ray diffraction technique is used to experimentally measure the residual stress distribution within the weld, for which the numerically predicted results exhibit a good agreement. Also, the numerical simulation and experimental measurements of the fatigue life versus the applied load show a good correlation of results.Copyright © 2012 by ASME and General Motors


The cut volute profile is far and widely used in the squirrel cage fan to meet the space limitation of range hood systems. The cut volute profile often causes unreasonable impeller–volute interference and the aerodynamic performance of the fan to drop. A numerical model combined with the neural network and the genetic algorithm of a squirrel cage fan volute for a range hood is presented in this paper. The secondary non-uniform B-spline curve represents the volute profile variation law, and its control points are used as design variables to meet space constraints. The goal of global optimization is to maximize the efficiency and volume flow rate. As a result of the optimization, the internal flow loss of the fan is reduced compared with the prototype. The volume flow rate and efficiency are increased by over 4.4% in case of optimized volute than the original configuration of the volute.


In this paper we outline the design for an indoor navigation system for the visually impaired. Our long-term goal is for a portable, self-contained system that will allow visually impaired individuals to travel through familiar and unfamiliar environments without the assistance of guides. The system, as it exists now, consists of the following functional components: (1) assistance for determining the user's position and orientation in the building, (2) a detailed map of the interior of the building, and (3) the user interface. By pressing keys on his/her mobile unit, directions concerning position, orientation and navigation can be obtained by the portable system that can prompt them acoustically over a text-to-speech engine.


PurposeThe study examines organizational security culture as the driver of supply chain security (SCS) practices (information management security, facility management security and human resource security). Additionally, the study examines the minimization of occurrence of supply chain disruption as the outcome of SCS practices.Design/methodology/approachA research model grounded on the contingency theory and the dynamic capabilities theory was developed and tested using partial least squares structural equation modelling (PLS-SEM). Data was obtained from 110 manufacturing and service firms in Ghana.FindingsIt was revealed that organizational security culture has a positive and a significant impact on information management security, facility management security and human resource security as hypothesized. In addition, facility management security significantly minimized supply chain disruption occurrence as hypothesized but information management security and human resource security did not.Originality/valueTo the best of the researchers' knowledge, this is the first study that examines organizational security culture as the driver of SCS practices. Additionally, the study is novel in examining the interplay between organizational security culture, SCS practices and supply chain disruption.


A net in $\mathbb{P}^2$ is a configuration of lines $\mathcal A$ and points $X$ satisfying certain incidence properties. Nets appear in a variety of settings, ranging from quasigroups to combinatorial design to classification of Kac-Moody algebras to cohomology jump loci of hyperplane arrangements. For a matroid $M$ and rank $r$, we associate a monomial ideal (a monomial variant of the Orlik-Solomon ideal) to the set of flats of $M$ of rank $\le r$. In the context of line arrangements in $\mathbb{P}^2$, applying Alexander duality to the resulting ideal yields insight into the combinatorial structure of nets.


The MPEG committee has completed development of a new audio coding standard called "MPEG-4 advanced audio coding-enhanced low delay" (AAC-ELD). AAC-ELD uses low delay spectral band replication (LD-SBR) technology together with a low delay time domain alias cancellation (LD TDAC) filterbank in the encoder to achieve both high coding efficiency and low algorithmic delay. In this paper, we present fast algorithms for implementing LD-TDAC filterbanks in AAC-ELD. Two types of fast algorithms are presented. In the first, we map LD-TDAC analysis and synthesis filterbanks to modified discrete cosine transform (MDCT) and inverse modified discrete cosine transform (IMDCT), respectively. Since MDCT/IMDCT are already extensively used in AAC and they have many fast algorithms, this mapping not only provides a fast implementation but also allows a common implementation of the filterbanks in AAC Low Complexity (AAC-LC), AAC Low Delay (AAC-LD) and AAC-ELD codecs. In the second algorithm, we provide a mapping to discrete Cosine transform of type II. The mapping to DCT-II allows the merger of the matrix operations with the windowing stage that precedes or follows them. This further reduces the number of multiplications and leads to an algorithm with the lowest known arithmetic complexity. For filterbanks of lengths 1024 and 960, we also present a new fast factorization of 15-point DCT-II that requires only 14 irrational multiplications, 3 dyadic rational multiplications and 67 additions.


Summary The aim of the study was to verify the efficiency of a traditional (technical) approach and a tactical game based approach to teaching minihandball game skills the first- to fourth-grade elementary school pupils. The experimental design was two parallel-group trials. Experimental groups (EG) were taught by the tactical approach where modified and small-sided games comprised 80 % and drill-exercises 20 % of all the units. Control groups (CG) were taught by the technical approach where drill exercises comprised 70 % and modified and small-sided games 30 % of all the units. Two groups of first- and second-graders (EG n=16, CG n=17) and two groups of third- and fourth-graders (both EG and CG n=12) attending extracurricular activities oriented to minihandball participated in the study. The technique of offensive game skills (overarm pass, dribbling and shot) was evaluated by 1 to 5 scoring system. For statistical analysis, Wilcoxon's T-test and Man-Whitney's U-test were used and the level of significance was set to 5 %. Based on the results it can be stated that the tactical approach is as efficient as a technical approach on game skills' technique acquirement. Results showed significant changes in the technique of game skills in both age categories (p<0.01). No significant differences between age categories were confirmed in game skill tests besides the dribbling test where the older experimental group (third- and fourth-graders) achieved better performance than the younger experimental group (first- and second-graders).


As the nurse supervisor of a home dialysis program, I admit that this has been one of the most challenging times of my dialysis career. The home program training facility is one of seven satellite dialysis facilities in the state of Vermont, and one of five satellite facilities that are under the umbrella of the University of Vermont Medical Center (UVMMC). Due to its physical layout and central location in the state, our training site was the ideal location for the UVMMC coronavirus disease 2019 (COVID-19) dialysis treatment facility. The resultant change in the use of our clinic space, however, has affected both our routine workflow and usual procedure practices, prompting us to reexamine unit operations.

Setting up our COVID-19 treatment corridor took careful planning, more planning, and replanning. We designated three of our six private exam rooms as COVID-19 treatment rooms and the hallway became known as the "COVID corridor." Additional travel staff were hired and a designated COVID-19 staff roster was developed. Our home program uses NxStage machines but, based on the number of estimated cases positive for COVID-19 and the limited number of staff familiar with NxStage technology, we decided to bring in Fresenius machines and portable reverse osmosis machines to dialyze the patients positive for COVID-19 in these rooms. There is a plan in place to employ NxStage machines if the number of patients exceeds the Fresenius fitted room capacity, but we have not needed to do so.

Having the right equipment available in the corridor has been essential to provide safe care and eliminate the need to send out for additional items necessary during treatment. Affording easy access to supplies and setting up makeshift storage areas was a struggle due to the limited corridor space, but with a lot of creativity and old-fashioned ingenuity, we …


Abstract. The apparent resistance to diffusion of water vapour presented by a set of holes in a calibration plate when measured by a commercial porometer depended on materials previously measured in the sensor head of the instrument. The data reported show the variation in apparent resistance of a set of holes with a specified value of 13.7 s cm−1 after a leaf of small resistance, a set of holes with a specified resistance of 3.75 s cm−1, or a hydrophobic membrane had been in the sensor head and the effect of covering the foam seal around the mouth of the cup with aluminium foil. It was concluded that the results were profoundly affected by the history of water vapour accumulation and release from the foam seal which could give rise to biased readings both during calibration and in measurements of leaf resistance and might also explain much of the scatter when calibration data obtained at different times were pooled for the calculation of a calibration equation. Reliable estimates of resistance over the effective range of the instrument cannot be expected unless this transfer of water vapour between the seal and the cup is prevented.


PURPOSE: To enable a consecutive molding of an extrusion profiles having excellent characteristics by rapidly compacting and extruding a material comprising a thermoplastic polymer and forcing the material through an aperture in die means so as to extrude it therethrough, the extrusion being made at below the melting point of the material. CONSTITUTION: As a wheel 11 rotates, a material 18 in a groove 13 is carried forward by a frictional drag of walls of the groove 13 and forced against an abutment portion 15. Pressure is thus generated in the material 18 so that it is rapidly compacted and forced through an orifice 16. This causes rapid heating of the material 18 and longitudinal orientation in the orifice 16. The heat sink provided by a shoe member 14 cools the material 18 almost immediately as the material 18 passes through the orifice 16 to an extent such as to substantially retain the desired longitudinal orientation in the extruded material 18. COPYRIGHT: (C)1990,JPO


Simulation codes for the paper: State-Based Delay Representation and Its Transfer from a Game of Pong to Reaching and Tracking


This paper looks at the death penalty in the United States and China with a comparison of the judicial system in each country. The paper examines the speed at which China processes their death penalty cases and the delay in the US system. The purpose of the paper is to show that because of the delays in the US system, the financial burden to the taxpayer is increased and is not viewed as deterrence. If the US were to adopt a portion of the Chinese judicial system efficiency without sacrificing due process, then the death penalty can be a deterrent on crimes that warrant the death penalty as well as saving tax payers money from having to support an inmate in the system as they attempt to draw out the process in a delayed system.


This work is concerned with the design of a hp-like discontinuous Galerkin (DG) method for solving the 2D time-domain Maxwell's equations on non-conforming locally refined triangular meshes. The proposed DG method allows non-conforming meshes with arbitrary-level hanging nodes. This method combines a centered approximation for the evaluation of fluxes at the interface between neighboring elements of the mesh, with a leap-frog time integration scheme.


By using the methods of table lookups, probability quantization and modified renormalization operations, a simple multiplication-free binary block arithmetic coding scheme is given. Experimental results show that its average codeword length is closer to the theoretic lower bound of source coding than many popular rapid coders.


in Streitwieser, B (ed . ) (2014) Internationalization of Higher Education and Global Mobility. Oxford Studies in Comparative Education 23(2). Oxford: Symposium, p. 59- 71.


The traditional medical splint has been used to fix fractures for many years. It can only rely on the doctor's experience to control the pressure which will directly affect the rehabilitation process of the fracture. A set of intelligent medical splints that can automatically detect pressure and body temperature is proposed in this paper. Firstly, wide splint which is one of the traditional four splints used for radial fracture fixation is redesigned and printed by 3D printing technique. On the basis of ergonomics, the splint adds high-density ventilation holes, the groove of the tie wire, contact points of sensor, groove of circuit and battery. Secondly, the pressure sensor was selected and the circuit was designed. The circuit can detect several channel of pressure and one channel of temperature, simultaneously. Furthermore, the smart splint can display the pressure and temperature values locally on an OLED display screen, and can also upload data to a mobile phone using Bluetooth. After using big data analysis of patient rehabilitation data, it can be find a better treatment plan for the fractures.


OBESO, J. R. & C. J. VILLALBA (1991). Morphology and reproduction in two Northern Spanish populations of Asphodelus albus Miller (Liliaceae). Anales Jara. Bot. Madrid 48(2): 189-200 (in Spanish). Relationships between sexual reproduction, vegetative multiplication, and genet morphology were studied in two populations of Asphodelus albus Miller (Liliaceae) in Northern Spain. The plant forms physically coherent clones composed of a heavily rhizomatous shoot system bearing tubers. Each genet develops different shoot modules (ramets) that also serve as the reproductive units. The modular root growth index (IC), a measure of the vegetative growth capacity of the clone, shows that as the size of the genet increases, the vegetative growth capacity becomes lower, probably due to biological constraints between size and physiological integration in the genet. There were significant effects of locality and density on genet morphology: genets growing in high density areas have higher ramet production. white in low density situations, vegetative growth is favored. Genets also show a positive relationship between density and photosynthetic tissue production (measured as dry weight), even when at least 70% of the total dry weight of the genet is invested in the large root system. Sexual reproduction requires a minimum size, both for the ramet and the genet bearing it. In the populations analized, there was usually only one ramet succesfully reproducing per


The small brown planthopper(SBPH),Laodelphax striatellus Fallen(Homoptera:Delphacide),is an economically important pest in rice(Oryza sativa L.) and distributes widely in China.It not only causes direct damage by sucking plant sap but also transmits several viral diseases such as Rice stripe virus(RSV) and Rice black-streaked dwarf virus(RBSDV),which often cause major yield losses..Host resistance has been recognized as one of the most economic and effective measures in controlling SBPH.Mudgo is one of indica rice cultivars with high resistance to SBPH,expressing strong antixenosis and antibiosis against SBPH.A genetic linkage map was constructed with an F2 population,derived from a cross between Mudgo and a japonica cultivar Wuyujing 3 for mapping QTLs associated with resistance to SBPH.The linkage map comprised 104 SSR and 3 Indel markers and covered 1 409.9 cM of rice genome with an average marker interval of 13.2 cM.One hundred and seventy-seven plants of F2:3 families were identified for resistance to SBPH by way of the modified seedbox screening test.QTL analysis of SBPH resistance was conducted using composite interval mapping implemented in Windows QTL Cartographer 2.5 software.A total of three QTLs,Qsbph2b,Qsbph3d,and Qsbph12a,conferring resistance to SBPH were detected on chromosomes 2,3,and 12,locating in the regions of RM5791-RM29,RM3199-RM5442,and I12-17-RM3331,with LOD scores of 3.25,3.11,and 6.82,respectively.The resistant alleles of Qsbph2b,Qsbph3d,and Qsbph12a,were all from Mudgo and could explain 17.3%,15.6%,and 35.8% of total phenotypic variance,respectively.Qsbph12a linked tightly to the markers RM3331 and I12-17 has a potential value in breeding for SBPH resistance by rapid marker-assisted selection.


In order to elucidate the relationship between talent recruitment and teacher allocation management in higher vocational colleges under the background of the "Double High Plan", this paper studies and analyzes the current status of talent recruitment in Chinese higher vocational colleges in conjunction with the characteristics of talent resource allocation in higher vocational colleges and proposes to elucidate the priorities and improve supporting policies with reasonable planning to improve the optimization guideline of talent recruitment efficiency, so as to better accomplish the building of the national "double high plan" and improve the ability of higher vocational colleges to nurture more outstanding talents for the society.


CONTEXT
Relations between thyroid function and lipids remain incompletely understood.

OBJECTIVE
Our objective was to determine whether lipoprotein subparticle concentrations are associated with thyroid status.

DESIGN AND SETTING
We conducted a prospective clinical study and cross-sectional cohort analysis at a university endocrine clinic and the Framingham Heart Study.

SUBJECTS
Subjects included 28 thyroidectomized patients with short-term overt hypothyroidism and 2944 Framingham Offspring cohort participants.

MAIN OUTCOME MEASURES
Fasting subclass concentrations of very-low-density lipoprotein (VLDL), intermediate-density lipoprotein, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) particles were measured by nuclear magnetic resonance spectroscopy. TSH values were also measured.

RESULTS
Total cholesterol and LDL-C were increased during short-term overt hypothyroidism. Large LDL subparticle concentrations increased during hypothyroidism (917+/-294 vs. 491+/-183 nmol/liter; P<0.001), but more atherogenic small LDL was unchanged. Triglycerides marginally increased during hypothyroidism, small VLDL particles significantly increased (P<0.001), whereas more atherogenic large VLDL was unchanged. Total HDL-C increased during hypothyroidism (76+/-13 mg/dl vs. 58+/-15 mg/dl; P<0.001). There was no change in large HDL-C particle concentrations, whereas small (P<0.001) and medium (P=0.002) HDL-C particle concentrations decreased. Among Framingham women, adjusted total cholesterol and LDL-C were positively related to TSH categories (P<or=0.003). This was due to a positive correlation between adjusted large LDL subparticle concentrations and log-TSH (P<0.0001); log small LDL subparticle concentrations decreased slightly as log-TSH increased (P=0.045). Among Framingham men, the only significant association was a positive association between log-TSH and log large HDL subparticle concentrations (P=0.04).

CONCLUSIONS
There is a shift toward less atherogenic large LDL, small VLDL, and large HDL subparticle sizes in hypothyroid women.


The consistency of commercial salad dressing, chocolate pudding and mustard samples before and after controlled disruption was assessed by squeezing flow viscometry and evaluated sensorily by an untrained panel. The instrumental parameters were the apparent stress at 1.5 and 1.0 mm height and the apparent residual stress after 60 and 120 s relaxation (at 1.0 mm height). The panelists were asked to identiff the sample(s) with the stronger consistency in a triangular test. The percent correct identifications was plotted against the difference in the magnitude of the instrumental parameters and their ratios. The scatter of these plots suggests that the effective stimulus for consistency perception was primarily the overall resistance to deformation or flow and to a much lesser extent to more subtle rheological characteristics like the 'degree of solidity'. In the range of consistencies examined, the detection thresholds were on the order of 0.5-0.7 kPa and 0.4-0.6 kPa at 1.0 and 1.5 mm height, respectively. They corresponded to stress ratios on the order of 0.75-0.85. Results of this kind will enable setting objective standards for the consistency of commercial semi liquid foods and tolerance margins to deviations from them.


The fourth compilation in a series is presented. The three preceding reports (ISC-796, ISC-812, and ISC906) contain similar information concerning Li, Na, K, Rb, Be, Mg, Cu, Ag, and Au. (J.R.D.)


Time dependent d. functional theory calcns. are completed for five Ni(II) complexes formed by polydentate peptides to predict the electronic absorption spectrum. The ligands examd. were glycyl-glycyl-glycine (GGG), glycyl-glycyl-glycyl-glycine (GGGG), glycyl-glycyl-histidine (GGH), glycyl-glycyl-cysteine (GGC), and triethylenetetramine (trien). Fifteen functionals and two basis sets were tested. On the basis of the mean abs. percent deviation (MAPD), the ranking among the functionals is: HSE06 ∼ MPW1PW91 ∼ PBE0 > ω-B97x-D ∼ B3P86 ∼ B3LYP ∼ CAM-B3LYP > PBE ∼ BLYP ∼ BP86 > TPSS > TPSSh > BHandHLYP > M06 » M06-2X. Concerning the basis sets, the triple-ζ def2-TZVP performs better than the double-ζ LANL2DZ. With the functional HSE06 and basis set def2-TZVP the MAPD with respect to the exptl. λmax is 1.65% with a std. deviation of 1.26%. The absorption electronic spectra were interpreted in terms of vertical excitations between occupied and virtual MOs based on Ni-d AOs. The electronic structure of the Ni(II) species is also discussed. [on SciFinder(R)]


The purpose of this article is to analyze Mexico's system of legal education, which, in a narrow sense, refers to the study of the "Licenciatura en Derecho" and the process for obtaining the license to practice as a lawyer. The study concentrates on three issues: (a) the procedure to obtain the license to practice law in Mexico; (b) the content and structure of the law program; and (c) the increase in the number of law schools during the last decade, focusing on the causes and characteristics of this growth.


Spin reorientation transitions of Co and Ni thin films induced by surface chemisorption have been investigated for CO-adsorbed Co/Pd(111) and CO- and H-adsorbed Ni/Cu(001) by means of Co L I I I , I I - and Ni L I I I , I I -edge x-ray magnetic circular dichroism (XMCD). For four to six monolayer (ML) Co/Pd(111), a spin reorientation transition from surface parallel to perpendicular magnetization has been observed at 200 K after CO dosage. The region of perpendicular magnetic anisotropy (PMA) becomes about 3 ML thicker at this temperature. For Ni/Cu(001), similar transitions have been confirmed when the layers are covered with CO or H, and the PMA range is also expanded, in this case by about 2 ML. The observed stabilization of perpendicular magnetic anisotropy due to chemisorption is ascribed to quenching of the surface parallel magnetic orbital moment. The effects of the fashion in which adsorption occurs on the easy axis of thin-film magnetization are also examined by comparing the differences in behavior between CO- and H-adsorbed Ni films.


The article analyses two clinical cases of patients with thrombophilia and violations resulting from genetically hemostasis system during pregnancy. Using the thromboelastography assessed the status of all links of blood coagulation, platelet plasma hemostasis and fibrinolysis system, tested the effectiveness of assigned patients to drugs (anticoagulants, antiagregants, inhibitors of fibrinolysis) and the adequacy of selected dosage. Performance of thromboelastography in dynamics made it possible to assess the effectiveness of the molecular heparin therapy during pregnancy and to identify appropriate ways of its correction in preparation for childbirth to prevent bleeding. Evaluating the clinical observations, it can be concluded on the need for thromboelastography in pregnant women at risk (genetically deterministic thrombophilia) or violations of the hemostatic system. Conducting a functional test with heparinaza enhances diagnostic validity thromboelastography.


This Article is brought to you for free and open access by the Theological Studies at Digital Commons @ Loyola Marymount University and Loyola Law School. It has been accepted for inclusion in Theological Studies Faculty Works by an authorized administrator of Digital Commons@Loyola Marymount University and Loyola Law School. For more information, please contact firstname.lastname@example.com. Repository Citation Chapple, Christopher Key, "The Practice of Modern Yoga: Sri Ramakrishna's Four Contributions" (2011). Theological Studies Faculty Works. 23. http://digitalcommons.lmu.edu/theo_fac/23


In the early 1970s, the screening of over 500 amphibian species led to the discovery by two independent investigators of several structurally related peptides from amphibian skin now referred to as the bombesin (BN) family of peptides. These peptides were classified into three subfamilies (bombesin, ranatensin and litorin) based on their carboxy terminal amino acid sequences. Subsequently, two mammalian peptides were identified that showed remarkable sequence homology with other members of this family. Neuromedin B (NMB), a decapeptide originally isolated from porcine spinal cord, bears close structural homology with ranatensin whereas gastrin-releasing peptide (GRP) isolated from porcine stomach shares the same carboxy terminal heptapeptide sequence with BN and similar biological activity.

In mammals, this family of peptides is composed of three known subtypes of closely related G-protein-coupled receptors. Two subtypes, neuromedin B receptor (NMB-R or BB1) and gastrin-releasing peptide receptor (GRP-R or BB2), were initially identified and characterized in the periphery and brain by pharmacological methods. GRP-R was shown to have a greater than 50-fold higher affinity for GRP than NMB, while NMB-R had a 100-fold higher affinity for NMB than GRP. Subsequently, these receptors were cloned, and an additional mammalian BN receptor subtype, BN receptor subtype-3 (BRS-3 or BB3) was identified through homology screening and found to share approximately 50% identity with GRP-R and NMB-R; however, the natural ligand for this receptor has not been identified.

These peptides have distinct distributions throughout the periphery and central nervous system and possess a wide spectrum of biological activity. Many of the actions of NMB are similar to those of BN or GRP but are frequently less potent in stimulating these actions. In the periphery, NMB has been shown to contract rat uterus and gastrointestinal smooth muscle and stimulate the release of several gastrointestinal and pancreatic peptides. Relevant to this discussion, exogenous administration of BN-like peptides suppresses food intake after either peripheral or central administration with the rank order of inhibition being BN > GRP > NMB. The development of specific BN receptor antagonists was instrumental in demonstrating that NMB acted independently of GRP to suppress food intake. However, the lack of a robust effect on food intake made it the 'underdog' of bombesin-like peptides and consequently it received very limited attention as a satiety peptide.

Because of complications in interpreting much of the pharmacological data, Ohki-Hamazaki and colleagues developed mice with specific deletions of the three mammalian BN receptor subtypes to help elucidate their physiological roles (Ohki-Hamazaki et al. 2005). It was found that deletions of BRS-3 resulted in an obese phenotype with deficits in energy regulation and an increased preference for sweet taste. Mice lacking GRP-R exhibited deficits in meal-related satiety signalling and developed late onset obesity. Despite an apparent role for NMB in food intake, the phenotype of mice with a targeted deletion of NMB-R could only be characterized as unremarkable. Mice deficient in NMB-R exhibited normal body weight and chow intake, and showed no differences in taste preference for palatable foods compared to wild-type mice.

However, a variety of behavioural tests in NMB-R knockout (KO) mice have suggested that NMB plays a role in anxiety and stress-related behaviours.

In this issue of The Journal of Physiology, Paula et al. (2010) have conducted experiments in female NMB-R-deficient mice that reveal a previously undetected phenotype with important implications in food intake and energy balance. As reported previously, when female NMB-R KO mice were fed a standard chow diet their food intake and body weight did not differ from wild-type (WT) mice. However, when challenged with a high-fat diet NMB-R KO mice were partially resistant to the obesogenic effects of the high fat diet. Remarkably, NMB-R KO mice consumed the same number of calories as WT mice but failed to gain significant body weight. Consistent with this, the authors demonstrate that high-fat-fed NMB-R KO mice exhibited less adipose tissue hypertrophy and adipose tissue mass than similarly fed WT mice. Because no differences in adipose tissue mass were demonstrated between NMB-R KO and WT mice fed a normolipid diet, the authors suggest that NMB-R KO mice must increase their energy expenditure in response to high-fat feeding. Unlike high-fat-fed WT mice, NMB-R KO mice did not exhibit impairments in glucose tolerance. Since NMB-KO mice were consuming the same amount of food as WT mice, this suggests that diet composition alone was not contributing to impaired glucose tolerance but that the latter was probably dependent upon increased body weight.

The results of this study highlight a renewed interest in NMB as an important component in energy balance regulation. Recent studies have shown NMB and NMB-R to be significant regulators of the hypothalamic-pituitary-adrenal axis through modulation of thyrotropin secretion (Oliveira et al. 2007). Studies by Hoggard et al. (2007) have demonstrated that NMB mRNA is present in human and rodent adipose tissue and that expression levels can be altered by changes in energy balance and leptin signalling. Moreover, electrophysiological studies have shown a robust excitatory effect of NMB on neuropeptide Y neurons in the arcuate nucleus, a brain region that is critical to energy homeostasis (von den Pol et al. 2009).

In humans, NMB has been suggested as a strong candidate gene linking eating behaviours to the susceptibility to obesity (Bouchard et al. 2004). The Quebec Family Study, a large prospective study designed to identify the genetics of obesity and related diseases, found that a missense mutation within exon 2 of the NMB gene was significantly associated with eating behaviours and obesity. This mutation resulted in twice as much body fat gain over a 6 year period compared to those without the mutation. How these data mesh with the results from the present study remains to be determined; however, they do suggest that NMB/NMB-R pathways may play a critical role in adipose tissue deposition or metabolism and provide a potential target for therapeutic intervention in the control of body weight.


Poppy Haynes is currently a student at Otago University in Dunedin, studying toward a B.A. in English and a B.S. in genetics. She is passionate about language, loves writing, and has been composing poetry for as long as she can remember. "Had I an Intelligent Dolphin" won the Bell Gully National Schools Poetry Award in 2004, when Haynes was a student at Chilton Saint James School in Lower Hutt. Copyright © 2004 by the author. 1 I


Title: The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma Authors: Ling-Wei Hii (email@example.com) Swee-Hua Lim (email@example.com) Chee-Onn Leong (email@example.com) Swee-Yee Chin (email@example.com) Ngai-Paing Tan (firstname.lastname@example.com) Kok-Song Lai (email@example.com) Chun Wai Mai (firstname.lastname@example.com) Version: 1 Date: 25 Jun 2019 Author's response to reviews: Authors' response to reviewers' comments on the paper "The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma"


Proceeding from the governing equations describing a saturated poroelastic material with intrinsically incompressible solid and fluid constituents, we compare the monolithic and splitting solution of the different multi‐field formulations feasible in porous media dynamics. Because of the inherent solid–fluid momentum interactions, one is concerned with the class of volumetrically coupled problems involving a potentially strong coupling of the momentum equations and the algebraic incompressibility constraint. Here, the resulting set of differential‐algebraic equations (DAE) is solved by the finite element method (FEM) following two different strategies: (1) an implicit monolithic approach, where the equations are first discretized in space using stable mixed finite elements and second in time using stiffly accurate implicit time integrators; (2) a semi‐explicit–implicit splitting scheme in the sense of a fractional‐step method, where the DAE are first discretized in time, split using intermediate variables, and then discretized in space using linear equal‐order approximations for all primary unknowns. Finally, a one‐ and a two‐dimensional wave propagation example serve to reveal the pros and cons in regard to accuracy and stability of both solution strategies. Therefore, several test cases differing in the used multi‐field formulation, the monolithic time‐stepping method, and the approximation order of the individual unknowns are analyzed for varying degrees of coupling controlled by the permeability parameter. In the end, we provide a reliable recommendation which of the presented strategies and formulations is the most suitable for which particular dynamic porous media problem. Copyright © 2009 John Wiley & Sons, Ltd.


Mediation is perceived to be the most effective way in resolving disputes. It is presumed that people prefer a more non-adversarial, non-competitive, lessdamaging, less-costly, more time-effective way of settling their disputes. Mediation is also supposed to be the way forward in order to implement a successful reform in the civil justice system. In spite of the so called highly acclaimed, efficient and effective process, have you ever wondered as to why mediation has very few users? Why is it that, after almost half a century of mediation programs implemented by institutions, courts and policy-makers, mediation is still a marginally used method of dispute resolution, in spite of its obvious advantages? Why mediation has not become the success it was supposed to be?


From his earliest work to his most recent, David Malouf's oeuvre has consistently employed epiphanies to the point where such moments of heightened sensation, personal enlightenment or deep realisation and wonderment have become a defining hallmark of his writing. Focusing on Malouf's early novel 'Johnno' and his short fiction 'Closer' and 'Southern Skies' this paper critically examines his use of epiphanies from a queer theoretical framework.


This article considers the reasons for the aggravation of the ecological situation which manifested itself in the wind erosion of soil over vast territories during the mass development of virgin lands in the Soviet Union through the prism of the history of agricultural science. The author refers to materials from central and regional archives, most of which are being introduced into scholarly circulation for the first time; the article also refers to special agricultural literature. The author outlines the main approaches to solving the grain problem in the eastern part of the USSR: the introduction of new territories into agricultural use, on the one hand, and the introduction of new varieties of grain crops into production, on the other. In conditions where the main attention of the state was directed to accelerated industrialisation, scientists considered these approaches the most accessible and realistic. It is substantiated that the subsequent reorientation of science towards selection as the main means of developing agricultural production led to the curtailment of research in the field of soil science and agricultural technology. According to the author, this negatively affected both the process of allocating land for virgin land development and limited the possibilities of science in terms of the operational development of a soil-protective system of agriculture. Later, by the end of the 1950s, the accumulation of virgin soil experience and research by scientists made it possible to propose recommendations to ensure soil protection from wind erosion. However, their implementation was restrained by the predominance of administrative approaches in implementation activities and the associated mistrust of production workers in the recommendations of science. The author concludes that the widespread introduction of a soil-protective system of agriculture became possible only in the second half of the 1960s when the necessary state-legal and organisational-scientific conditions were created for this and administrative "excesses" were eliminated. The development of the entire front of scientific research and the formation of a mechanism for the rapid introduction of scientific recommendations into production are necessary conditions for the implementation of major national economic programmes.