Objective To assess the value of thin prep liquid based cytology test(TCT) and the Bethesda system(TBS) in diagnosis of cervical lesions.Methods The samples of atypical squamous cells(ASC)and more severe lesions were classified into the positive cytology,and then cytological results were compared with pathological examination results of cervical biopsies.Results Out of 4 032 cases of classified in cytology by TBS,257 positive cases were detected with the rate of 6.37%,157 cases were found with ASCUS and AGUS,54 cases with LSIL,38 cases with HSIL,8 cases with CA.Among them,190 cases with positive cytologic results received biopsy by colposcopy.45.3% patients were with CIN.The positive pathological rate of ASC+AGUS,LSIL,HSIL,CA were 36.5%,53.2%,71.9% and 100%,respectively.Positive cytologic results of TCT were of significant correlation with the positive pathologic diagnosis(P0.01).Conclusions TCT technique is necessary for screening uterocervical disease.Cytologic diagnosis combined with colposcopy and pathologic biopsy can contribute to both the early discovery of intraepithelial neoplasia and prevention of uterocervical cancer.


Microsoft.com, is the world's largest corporate website both in terms of site visitors and pages served. Overall, it is the fourth-largest website in total visitors behind America Online, Yahoo and Netscape. We offer 250,000 pages of content, viewable in all major browser versions (yes, we aggressively support Netscape), supported by three server farms internationally and featuring content updated as often as every three hours, seven days a week.


The Common-Reflection-Surface (CRS) stack method provides kinematic wavefield information in a highly-automated way from seismic reflection data. Together with a tomographic inversion scheme based on this information a fast and robust imaging workflow can be established. In order to be of use in the inversion the kinematic wavefield information has to be appropriately preconditioned and extracted. In this abstract we briefly review the basics of the CRS stack and the related inversion. The main topic is the presentation of simple and robust strategies to remove outliers as well as fluctuations from the wavefield attributes and to extract reliable attributes suited for the inversion process.


Abstract Purpose: To create an evaluation plan for the World Federation for Medical Education (WFME) accreditation standards for basic medical education. Methods: We conceptualized the 100 basic standards from "Basic Medical Education: WFME Global Standards for Quality Improvement: The 2012 Revision" as medical education program objectives. Standards were simplified into evaluable items, which were then categorized as inputs, processes, outputs and/or outcomes to generate a logic model and corresponding plan for data collection. Results: WFME standards posed significant challenges to evaluation due to complex wording, inconsistent formatting and lack of existing assessment tools. Our resulting logic model contained 244 items. Standard B 5.1.1 separated into 24 items, the most for any single standard. A large proportion of items (40%) required evaluation of more than one input, process, output and/or outcome. Only one standard (B 3.2.2) was interpreted as requiring evaluation of a program outcome. Conclusions: Current WFME standards are difficult to use for evaluation planning. Our analysis may guide adaptation and revision of standards to make them more evaluable. Our logic model and data collection plan may be useful to medical schools planning an institutional self-review and to accrediting authorities wanting to provide guidance to schools under their purview.


Tang--Jiang pericyclic selection rule, which is only applicable to cycloaddition reactions, is simplified. The simplified Tang--Jiang pericyclic selection is suitable for all the simply connected pericyclic reaction systems and therefore has obvious universality.


These lectures form a general introduction to the domain of Quantum Optics, with a special emphasis on the notion of field eigenmodes that are necessary to describe the quantum effects in light and define the photons: possibility of changing the basis of field eigenmodes and choosing the most appropriate one, definition of intrinsic properties, independent of the choice of basis. Are successively studied the single mode quantum effects, the quantum correlations existing in bimodal systems, and some interesting features of highly multimode systems such as the optical images.


Methods and systems are provided for treating a vascular structure having a defect, for example, a cerebral artery having a weakened wall that has formed an aneurysm. The methods include substantially entrapping a quantity of blood within a vascular defect, and introducing a quantity of a crosslinking agent, for example as a liquid solution, into the entrapped blood. The crosslinking agent is a compound in which each molecule of the compound has at least two nucleophilic-reactive functional groups. The crosslinking agent is allowed to combine with and react with the substantially entrapped blood, and a substantially solid mass made of crosslinked blood is formed within the defect.


The androgenetic embryo is a useful model for investigating the contribution of the paternal genome (e.g. genomic imprinting) to embryonic development. Few works on androgenetic embryo production in domestic animals exist. In this study, we compared the developmental ability of diploid, haploid, and triploid androgenetic sheep embryos. In vitro-matured metaphase II oocytes were enucleated in HEPES-buffered TCM-199 with cytochalasin B (7.5 µg mL−1) and Hoechst 33342 (5 µg mL−1) under UV light using a Narishighe Micromanipulator fitted to an inverted Nikon microscope. Enucleated oocytes were fertilized in vitro with a high sperm concentration (2.5 × 107 sperm mL−1). Fifteen hours after in vitro fertilization (IVF), embryos were centrifuged (12 000g for 10 min) to visualize the pronuclei; the number of pronuclei were scored under the inverted microscope. In Experiment 1, IVF (control), haploid (1 pronucleus), diploid (2 pronuclei), and triploid (3 pronuclei) embryos were cultured in SOFaa medium with BSA, according to the protocol in our laboratory (Ptak et al. 2002 Biol. Reprod. 67, 1719–1725). In Experiment 2, we performed pronuclear transfer to produce diploid embryos. A single pronucleus was aspirated with a bevelled pipette from haploid (haploid + haploid) or diploid (diploid + haploid) embryos and transferred into the perivitelline space of another haploid embryo. The reconstructed zygotes were electrofused in 0.27 M mannitol solution with 50 µM CaCl2 and 100 µM MgCl2 by a single DC pulse (0.8 kV cm−1 for 80 µs). As a control group for Experiment 2, IVF embryos (pronuclear stage) were centrifuged, followed by the aspiration of a small volume of cytoplasm, and fused under the same condition of diploidization. In Experiment 1, there was no significant difference in cleavage rate (91% to 98%), but there was a significant difference on blastocyst development between IVF and androgenetic embryos (IVF: 43% (26/60); haploid: 0% (0/37); diploid: 1% (1/73); and triploid: 2% (1/48)). In Experiment 2, there was no significant difference in cleavage rate (94% to 100%). However, there was a significant difference on blastocyst development (Control: 42%; haploid + diploid: 19%; and haploid + haploid: 3%; Table 1). Our results suggest that sheep androgenetic embryos show poor developmental ability compared with IVF embryos. Interestingly, diploid androgenetic embryos produced by IVF displayed very poor development; however, such poor development was rescued, for unknown reasons, by pronuclear transfer. Ongoing experiments will provide new insight into this previously uncharacterized phenomenon. In conclusion, pronuclear transfer was an effective method for producing sheep androgenetic blastocysts in vitro. Table 1.Development of androgenetic embryos after pronuclear transfer


The size–frequency distribution (SFD) of objects across the solar system is influenced by their formation and dynamic evolution. Bodies in different areas of the solar system—especially the inner versus outer—have likely experienced different histories, so measuring that SFD across orders of magnitude of solar distance can elucidate those different pasts. Accurate measurement of the SFD is greatly assisted by impact craters, formed from the smaller bodies that strike much larger ones, and it is often easier to measure impact craters' SFDs than the smaller impactors themselves. One of the main results from New Horizons' Pluto–Charon encounter was the crater SFD measurement, which illustrated an unexpected SFD with a distinct change in slope near ≈10–15 km diameter features. However, different methods of reporting these impact craters have resulted in some questions in the community about what the SFD actually is of Pluto's and Charon's crater population and therefore what the SFD is of the impactors that formed them. We have performed new crater population studies on both bodies, compared them with previously published work, and demonstrated that there is no ambiguity with respect to whether there is a transition to a shallower SFD population near ≈10–15 km. We find that this shallower slope is approximately −1.7 ± 0.2, while the steeper slope for larger craters is approximately −3.8 ± 0.6, though both of these uncertainties must be considered absolute minima based on fit sensitivity to the exact parameters and craters used. These values are consistent with previously reported results.


P sychiatrists' eyes may glaze upon encountering an article with " economic " in the title and containing jargon like " QALY " (quality-adjusted life-years) and " nonparametric bootstrap replication. " As a profession, psychiatrists are not terribly good with numbers and money (or we' d be in better economic shape). Yet the study by Bamelis and colleagues in this issue 1 deserves your rapt attention. As a non-economically focused psychiatrist, I recommend it to you. There is a dearth of good studies of the cost-effectiveness, cost-utility, and cost-offset of psychiatric treatments, particularly psychotherapies. The authors of this sophisticated Dutch multisite trial compared the costs of schema therapy, clarification-oriented therapy, and treatment as usual (which in the Netherlands tends to mean adequate treatment) in a large randomized trial of 320 patients meeting DSM-IV criteria for avoidant, dependent, obsessive-compulsive, paranoid, histrionic, or narcissistic personality disorders. Schema therapy, the most clinically effective treatment, also had the best economic outcomes across a broad range of health-related and other societal variables. It is interesting to study the costs of treating personality disorders, which by definition are chronically debilitating and for which psychotherapy is the keystone of treatment. Moreover, the 6 personality disorders studied have received relatively little treatment attention relative to borderline personality disorder. Historically, the first hurdle psychotherapy research had to leap was whether psychotherapy worked. 2 With several psychotherapies having now amply demonstrated efficacy and effectiveness for multiple diagnoses, including some personality disorders, the next hurdle for psychotherapy may be cost. In the United States, insurance companies have continued to reward psychiatrists for prescribing medications rather than sitting, listening, and talking with patients, which the insurers still seem to consider an endless process and a black hole for costs. Even though most patients with mood and anxiety disorders prefer psychotherapy to pharmacotherapy, 3 the ratio of treatments they are receiving has increasingly tilted toward pharmacotherapy, 4 no doubt in part because of wrong-headed insurance-related economic incentives. 5 Personality disorders are precisely the sort of diagnoses insurance companies have most feared: chronic conditions requiring potentially endless, costly psychotherapy. This study shows not only that patients with personality disorders improved but also that delivering effective treatment saved money. American psychiatrists and other mental health professionals interested in preserving (and prescribing) psychotherapies should thank our Dutch colleagues for this economic research supporting the use of talking therapy for personality disorders. This is a study to …


Abstract Mica is the substrate of choice for microscopic visualization of a wide variety of intricate nanostructures. Unfortunately, the lack of a facile strategy for its modification has prevented the on‐mica assembly of nanostructures. Herein, we disclose a convenient catechol‐based linker that enables various surface‐bound metal‐free click reactions, and an easy modification of mica with DNA nanostructures and a horseradish peroxidase mimicking hemin/G‐quadruplex DNAzyme.


Autoradiography of some labelled steroid hormone precursors in mice has shown that these substances are localized to a great extent in sites of steroid hormone formation (Appelgren, 1967). Pregnenolone\p=m-\the immediate pre-cursor of progesterone\p=m-\was specifically accumulated in the corpora lutea


SINCE THE 1960s, there has been a renewal of interest in the classical theory of the balance of payments, with important contributions by Johnson [4] and Mundell [7, 8]; the resulting modern version is known as "the monetary approach" to balance-of-payments theory. The pioneering work of Johnson and Mundell has been followed by a number of theoretical refinements and by several empirical tests of the theory for small countries [2]. This paper presents an empirical test of a large country case, viz. the United States in the period 1951-73. Section 1 sets out a simple two-area model of the world from which the U.S. balance-ofpayments equation is derived. The empirical tests of this equation are discussed in section 2. The monetary approach considers balance-of-payments deficits and surpluses as stock adjustments to money market disequilibrium, or as continuous flow disturbances resulting from ongoing stock adjustments. The most important assumptions


The article touches upon the genre of travelling as a particular form of pieces of description with the special character of narrator. The article analyzes the works of L. Stern, D. Fonvizin, N. Karamzin, I. Goncharov. A special attention is paid to the interrelation between Russia and the West, The dialogue of cultures.


Studies of endothelium remain a cornerstone of research in vascular biology, having very broad potential and implications. At a basic level, this research attempts to understand the intricacies of normal biology of endothelial cells. Such knowledge should provide the foundation for understanding molecular mechanisms that contribute to and protect from endothelial dysfunction in disease states. Ultimately, this …


INTRODUCTION. THE observations embodied in this communication arose in an attempt to discover why some cases of opisthotonus in rice-fed birds could be cured by giving glucose alone [Kinnersley, Peters and Reader, 1928]. This fact, beyond proving incontestably that all symptoms of opisthotonus produced by rice feeding were not due to lack of vitamin B1, suggested an intimate relation between the symptoms and some phase of carbohydrate metabolism. It seemed possible that investigation of the relation between these symptoms and carbohydrate metabolism might shed light upon the metabolic lesion in avitaminosis proper. In this paper, it is shown that more lactic acid is present in the brain of a pigeon suffering from "avitaminous" opisthotonus than in that of the normal'.


Australian developers are working on a tool to help detect pain in non-communicative people living with dementia, writes Natasha Egan.


A real-time cross-correlation between concentration, temperature and electrical conductivity of KDP aqueous solution was determined by using an transformer-type conductivity sensor. This correlation can be expressed by L(Ts,t) = L0(t) + b1(t)Ts + b2(t)Ts2. On the base of the correlation, a computer system was made to realize the in-line measurement and control of the supersaturation of the growth solution. The system can control the supersaturation within ±0.049 KDP/100g water (±0.12% relative supersaturation). The system was used to study the relationship between the supersaturation of the growing solution and the properties of the crystals grown from different raw materials. It was found that growth rate rise but the homogeneity of KDP crystal goes down as the supersaturation increases. The system makes KDP crystal growing under a stable supersaturation and the growth band and scattering particles inside the crystals suppressed, so the optical transmittance and laser damage threshold of the crystal improved.


The changing nature of organisation life becomes more and more intense as organisations are constantly striving to adjust to serve the needs of an ever-changing environment. At the same time, the i ...


Objective To explore feasible and effective measures for clinical departments to carry out nursing research.Method Set up the scientific research guide team and established the objectives of scientific research to carry out scientific research.Results This practice inspired the nurses' innovation thought and enthusiasm of scientific research.As a result,both the quantity and quality of published papers raised year by year.The total number of published papers in 2004 was 6 times of that in 2001,and 2 research projects were applied for the research project of Department of Health of Jiangxi Province.And all the nurses participated in nursing research actively.Conclusions Carrying out nursing research in the department could improve the quality of nursing and nurses' consciousness and level of scientific research.


-Werschkul and Jackson (1979) suggested that sibling competition is a dominant force in the evolution of avian growth rates. Two predictions of this hypothesis, (1) that species with broods of one (Bi) should grow more slowly than those with larger broods (B2+), and (2) that growth rates should be more variable among Bi species than among B2+ species, are confirmed. A simple numerical calculation illustrates that sibling competition may exert very strong selection on growth rate compared to that of extemal mortality factors, provided that growth rate accurately predicts the outcome of competition between sibs. The results of such selection depend on the evolutionary flexibility of growth rate in response to factors causing mortality of nestlings. Attempts to relate growth rate to total mortality rate of nestlings and to mortality within broods failed. Hence, I could find neither direct support for the sibling-competition growthrate hypothesis nor evidence for flexibility of growth rate with respect to nestling mortality. Three alternatives for slow growth among Bi species are discussed: (1) limitation by availability of food, (2) limitation by the availability of essential nutrients in the diet, and (3) increased precocity of the chicks of Bi species. Received 11 August 1980, accepted 19 May


Claiming that great powers determine the character of an international system is unremarkable. The difficult task is to show how great powers have created and maintained an international system that works in their interests. This is the job Alex Roberto Hybel undertakes in Made by the USA. He seeks to show how the United States first responded to the Europedominated state system, and then upon rising to great power status, how it sought to shape the international system to its own benefit. The contemporary relevance of Hybel's effort is for assessing whether the United States can maintain control over the international system into the twenty-first century.


The success of the Party of Democratic Socialism (PDS) cannot be explained solely with a rising tide of GDR nostalgia and/or with the efficiency of PDS members as service providers and advocates at the grass‐roots level. We stress the importance of the PDS as the main political representative of a specific socio‐economic and cultural milie in the former GDR. Furthermore, the article traces the evolution of the PDS from a populist voice of protest of the losers of unification to the beginnings of a new political party. As such it defines its identity more as a radical left‐wing party with strong social libertarian characteristics than a traditional socialist party. The party programme and the electorate of the PDS display remarkable similarities to the fundamentalist wing of the West German Greens in the 1980s, although differences as to the origins of the left‐libertarian ideas remain important. While the PDS seems to have strengthened the significance of the new politics agenda in post‐unification German...


AIM OF THE STUDY Investigate a possible synergistic effect of smoking and exposure to formaldehyde upon micronucleus in lymphocytes and mucosa buccal cells, nucleoplasmic bridges and nuclear buds INTRODUCTION Formaldehyde (FA) is a colourless gas widely used in the industry and hospitals as an aqueous solution, formalin. It is extremely reactive and induces various genotoxic effects in proliferating cultured mammalian cells.Tobacco smoke has been epidemiologically associated to a higher risk of development of cancer, especially in the oral cavity, larynx and lungs, as these are places of direct contact with many carcinogenic tobacco's compounds. Approximately 90% of human cancers originate from epithelial cells. Therefore, it could be argued that oral epithelial cells represent a preferred target site for early genotoxic events induced by carcinogenic agents entering the body via inhalation and ingestion. The cytokinesis-blocked micronucleus assay (CBMN) in human lymphocytes is one of the most commonly used methods for measuring DNA damage, namely the detection of micronucleus, nucleoplasmic bridges, and nuclear buds.


One of the main glacier-related natural hazards that are common to alpine locations is the occurrence of glacial lake outburst floods (GLOFs), which can seriously harm downstream towns and infrastructure. GLOFs have increased in frequency in the central Himalayas in recent years as a result of global warming, and careful management of glacial lakes is a crucial step in catastrophe prevention. In this study, field surveys were conducted on 28 August 2020 and 1 August 2021 with the help of an unmanned aerial vehicle (UAV) and a boat bathymetric system on an unmanned surface vessel (USV), combined with 22 years of Landsat series imagery and Sentinel-2 MSI imagery data. Spatial analysis was then used to investigate changes in lake surface conditions, dam stability, and surrounding topography before and after an integrated project of the Jialong Co lake. The results show that: (1) from 2000 to 2020 (before engineering management), the area of the Jialong Co glacial lake increased from 0.2148 ± 0.0176 km2 to 0.5921 ± 0.0003 km2. The glacial lake expansion rate from 2000 to 2010 (0.0145 km2/a) was greater than the rate from 2011 to 2020 (6.92 × 10−6 km2/a). In 2021 (after engineering treatment), the glacial lake perimeter, area, and volume decreased by 0.6014 km, 0.1136 km2, and 1.90 × 107 m3, respectively. The amount of excavation during the project treatment was 8.13 million square meters, and the amount of filling was 1.24 million square meters. According to the results of the unmanned surface vessel (USV), the elevation of the lake surface dropped from 4331 m to 4281 m, and the water level dropped by 50 m (the designed safe water level line dropped by 30 m). (2) The results of the UAV topographic survey and geomorphological analysis showed that the engineered reinforcement of the outlet channel and surrounding dam effectively mitigated severe scouring of the foot of the final moraine at the outlet of the spillway, as well as the likelihood of glacial lake outbursts caused by ice avalanches and landslides. (3) The comprehensive engineering treatment of this typical glacial lake effectively lowered the water level and improved the stability of the moraine ridge and lake dam, providing a scientific foundation for other glacial lake outburst risk assessments and disaster mitigation and management measures. Thus, it is critical to evaluate the impact of comprehensive engineering management of key glacial lakes to support glacial lake management.


Two time delay compensation techniques, the Smith predictor and the analytical predictor, are used for bottom composition control of a pilot scale methanol-water distillation column. The closed-loop performance of the two predictor schemes is compared to that for a proportional-integral controller in experimental and simulation studies. The predictors resulted in improved control for both set point and feed flow disturbances.


Three models are currently used by the Maryland State Highway Administration for designing meanders on stream restoration projects. The first model is based on the relationship of bankfull channel width and meander wave length, the second is based on the relationship between bankfull channel width and the meander belt width and the third is based on the relationship between bankfull channel width and meander radius of curvature. In this study, watershed and meander characteristics from 24 Maryland streams were collected using both state topographic maps and field investigations. These data were then used to verify, the accuracy and quantify the uncertainties inherent in each of the three models. The determination of regression and physical parameter as well as model uncertainty will aid in a more reliable restoration of natural meander plan form to previously straightened streams.


On 25 August 2018 a day excursion in rock mass classification was organized in Bad Bentheim, Germany, by the Dutch Association of Engineering Geologists (Ingeokring). In the Sandstone Museum of Bad Bentheim a short presentation was given on the Slope Stability Probability Classification (SSPC) (Hack et al., 2003). A rock mass classification and slope stability assessment was done to show the practical application of the SSPC system in the nearby Romberg Quarry in Gildehaus


ABSTRACT
A 71-year-old man underwent 68Ga-PSMA PET/CT for evaluation of a late biochemical recurrence after radical prostatectomy. An intense PSMA uptake was identified in spleen. Additional evaluation with a contrast-enhanced MRI showed a splenic lesion consistent with splenic hemangioma.


According to the space geometry site relationship of active sonar, target and passive buoys in combine multi-base aviation searching submarine, the target location mathematical model which related with the sound transmission time from active sonar to passive buoys is established. The sound transmission times from active sonar to target to passive buoys and the azimuth angle of passive buoys are determined. Based on the mathematic model, the orientation error models which caused by time measurement error and azimuth measurement error are given. Finally, the location and error models are simulated and analysed.


Poultry livestock profitability significantly depends on feed, accounting for 60–70% of the total production cost, of which protein sources are among of the most expensive ingredients. The maintenance of profitability while meeting feed demand and reducing the environmental impact represents a considerable challenge driving research of alternative protein sources (APS), such as insects and algae meals. This study employs, for the first time, techno-economic assessment (TEA) methodology to evaluate the technological performance and the industrial feasibility of an APS-based poultry feed production method based on the valorization of the pre-treated organic fraction of municipal solid waste (OFMSW) as a substrate for Hermetia illucens larval growth and microalgae cultivation. The Excel-based analysis, which evaluated the mass and energy balance as well as the income statement, was integrated with a thematic analysis focused on exploring how the overall value attributed to the sustainability concept is reflected in the willingness to adopt sustainable business models by entrepreneurs in the poultry sector. Despite the ability to generate revenues, the model cannot be said to be profitable for animal feed production due to the strong dependence of its profitability on scale economy logics. Enabling solutions could be derived from the recovery of abandoned infrastructures, government financial incentives, and integrated systems associating OFMSW treatment with poultry farming, thus resulting in marked economic sustainability and profitability: key elements from the poultry entrepreneurs' point of view.


Research progress on the resources distribution,biological characteristics cultivation,breeding and conservation of Cypripedium was summarized.The conservation strategy and future development direction were discussed.


Abstract Background Cognitive deficits in schizophrenia are generalized, but memory and executive dysfunction represent the more robust impairments and are strongly associated with adverse social and occupational outcomes. Those deficits are present in all phases of the disease, but their course, particularly in the chronic phase, is less clear. The aim of this study is to investigate changes in the performance of chronic schizophrenia patients in tests of executive function over a seven-year test-retest period. Methods We will contact 85 patients with schizophrenia, considered clinically stable in previous year, who participated in a study about the deficit syndrome of schizophrenia in 2009–2010. Back then, they were recruited in two sites: an outpatient service of a general hospital (49 patients) and a community-based mental health service for patients with severe mental illness (36 patients), both in Campinas, Brazil. Patients will be reassessed with the same instruments adopted in the first study: SAPS; SANS; Calgary Depression Scale (CDS); Quality of Life Scale (QLS) and a battery of tests comprising Verbal Fluency Tasks; Digit Span Forward (DSF) and Backward (DSB) and Trail Making Tests (TMT) A and B. Additionally, we included three instruments: PSP, for social functioning; Wisconsin Card Sorting Test (WCST) and London Tower Test (LTT), for executive functions. The Wilcoxon test was used to compare executive performance at baseline and at follow-up. Linear regression was used to test associations between variables. We started the recruitment by the patients originally treated in the outpatient clinic. Results We present in this poster partial results. Among the 20 patients re-interviewed the mean age at baseline was 36.9 ± 8.9 years, mean duration of mental illness was 16 ± 10.1 years, 75% were men. They had in mean, 10.7 ± 3.3 years of education, only 20% had any work activity, and 15% were married. Mean length of test-retest interval was 6.9 years (minimum 6 and maximum 7.7). At follow-up, 4 patients had improved their education, but only 3 (15%) had any work activity. Up to now 19 patients completed the cognitive reassessment. We performed a principal components factor analysis (PCA) including DSB, TMT-B and VFT for both baseline and follow-up assessments. PCA yielded a single factor for the set of tests in both assessments, which we named Executive Factor, accounting for 57% of variance in baseline and 51.38% in the follow-up assessment. Factor scores were calculated and then compared: 7 patients had higher scores on Executive Factor in the follow-up and 10 had worse scores but differences were not significant. In the linear regression analysis, we did not find significant associations between performance in executive functions in the follow-up assessment and clinical and psychopathological variables neither at the baseline nor at the follow-up assessment. In the Wisconsin test, approximately 60% of the patients managed to form only up to 01 category, which is considered a bad performance. The mean score in LTT was 57.3 ± 10.6 for movements and 170.4 ± 125.2 for time. Discussion The results presented are partial, obtained with a provisional small sample size but they show some interesting trends. In general, there was a group tendency for a slightly worse performance after 7 years of the baseline assessment, but we could identify two groups of patients who differ from that general tendency: one with marked deterioration and one with improvement of executive performance over time. If those initial findings are to be confirmed, our next step will be to investigate characteristics associated to improvement or deterioration of executive performance. That sort of information is of great relevance in the pursuit of recovery for schizophrenia patients.


Sequencing units on a production or assembly line in order to attenuate the variations in the rates of resource consumption is a problem that has received growing attention in recent years. The present study features an analysis of the PRV (Product Rate Variation) problem with quadratic discrepancy function. Taking advantage of the properties satisfied by any optimum sequence, efficiency of several heuristic procedures is increased. Although an efficient exact method exists, these heuristics have a potential utility in developing procedures adapted to the industry. The results of a short computational experience are included.


Abstract STUDY QUESTION Can artificial intelligence (AI) algorithms developed to assist embryologists in evaluating embryo morphokinetics be enriched with multi-centric clinical data to better predict clinical pregnancy outcome? SUMMARY ANSWER Training algorithms on multi-centric clinical data significantly increased AUC compared to algorithms that only analyzed the time-lapse system (TLS) videos. WHAT IS KNOWN ALREADY Several AI-based algorithms have been developed to predict pregnancy, most of them based only on analysis of the time-lapse recording of embryo development. It remains unclear, however, whether considering numerous clinical features can improve the predictive performances of time-lapse based embryo evaluation. STUDY DESIGN, SIZE, DURATION A dataset of 9986 embryos (95.60% known clinical pregnancy outcome, 32.47% frozen transfers) from 5226 patients from 14 European fertility centers (in two countries) recorded with three different TLS was used to train and validate the algorithms. A total of 31 clinical factors were collected. A separate test set (447 videos) was used to compare performances between embryologists and the algorithm. PARTICIPANTS/MATERIALS, SETTING, METHODS Clinical pregnancy (defined as a pregnancy leading to a fetal heartbeat) outcome was first predicted using a 3D convolutional neural network that analyzed videos of the embryonic development up to 2 or 3 days of development (33% of the database) or up to 5 or 6 days of development (67% of the database). The output video score was then fed as input alongside clinical features to a gradient boosting algorithm that generated a second score corresponding to the hybrid model. AUC was computed across 7-fold of the validation dataset for both models. These predictions were compared to those of 13 senior embryologists made on the test dataset. MAIN RESULTS AND THE ROLE OF CHANCE The average AUC of the hybrid model across all 7-fold was significantly higher than that of the video model (0.727 versus 0.684, respectively, P = 0.015; Wilcoxon test). A SHapley Additive exPlanations (SHAP) analysis of the hybrid model showed that the six first most important features to predict pregnancy were morphokinetics of the embryo (video score), oocyte age, total gonadotrophin dose intake, number of embryos generated, number of oocytes retrieved, and endometrium thickness. The hybrid model was shown to be superior to embryologists with respect to different metrics, including the balanced accuracy (P ≤ 0.003; Wilcoxon test). The likelihood of pregnancy was linearly linked to the hybrid score, with increasing odds ratio (maximum P-value = 0.001), demonstrating the ranking capacity of the model. Training individual hybrid models did not improve predictive performance. A clinic hold-out experiment was conducted and resulted in AUCs ranging between 0.63 and 0.73. Performance of the hybrid model did not vary between TLS or between subgroups of embryos transferred at different days of embryonic development. The hybrid model did fare better for patients older than 35 years (P < 0.001; Mann–Whitney test), and for fresh transfers (P < 0.001; Mann–Whitney test). LIMITATIONS, REASONS FOR CAUTION Participant centers were located in two countries, thus limiting the generalization of our conclusion to wider subpopulations of patients. Not all clinical features were available for all embryos, thus limiting the performances of the hybrid model in some instances. WIDER IMPLICATIONS OF THE FINDINGS Our study suggests that considering clinical data improves pregnancy predictive performances and that there is no need to retrain algorithms at the clinic level unless they follow strikingly different practices. This study characterizes a versatile AI algorithm with similar performance on different time-lapse microscopes and on embryos transferred at different development stages. It can also help with patients of different ages and protocols used but with varying performances, presumably because the task of predicting fetal heartbeat becomes more or less hard depending on the clinical context. This AI model can be made widely available and can help embryologists in a wide range of clinical scenarios to standardize their practices. STUDY FUNDING/COMPETING INTEREST(S) Funding for the study was provided by ImVitro with grant funding received in part from BPIFrance (Bourse French Tech Emergence (DOS0106572/00), Paris Innovation Amorçage (DOS0132841/00), and Aide au Développement DeepTech (DOS0152872/00)). A.B.-C. is a co-owner of, and holds stocks in, ImVitro SAS. A.B.-C. and F.D.M. hold a patent for 'Devices and processes for machine learning prediction of in vitro fertilization' (EP20305914.2). A.D., N.D., M.M.F., and F.D.M. are or have been employees of ImVitro and have been granted stock options. X.P.-V. has been paid as a consultant to ImVitro and has been granted stocks options of ImVitro. L.C.-D. and C.G.-S. have undertaken paid consultancy for ImVitro SAS. The remaining authors have no conflicts to declare. TRIAL REGISTRATION NUMBER N/A.


This thesis investigated the way in which microgravity can affect the solidification process of metals. An understanding of this process is essential to improve the structures of metals and to support the merit of manufacturing in space. Materials that are processed in a microgravity environment can often exhibit unique properties such as an increase in ductility or stronger thermal properties.The main objective of this thesis was to outline a design of a drop package to be tested in the UQ drop tower. Other microgravity facilities were also explored to ensure the best conditions for testing.Testing in the UQ drop tower provided only 2s of microgravity. Thus it was challenging to design a drop package which would allow the metal to solidify in that short timeframe. Using Matlab, I was able to determine the necessary dimensions (30cm Length x 10 cm Height) of the design in order for solidification to occur. This design is able to test an aluminium sample of 5cm radius. Hopefully after future testing is conducted, We will be able to improve the quality of material processing and therefore enhance the properties of metals.


This letter proposes a novel consensus-based timetable algorithm (CBTA) to solve the decentralized simultaneous multi-agent task allocation problem. Due to the limited capability of each agent, multiple agents may be required to perform a task simultaneously. A key challenge is how to meet the requirements and minimize the average start time of all tasks. The proposed CBTA aims to minimize the start time of each task to minimize the average start time of all tasks indirectly, it iterates between a timetable construction phase and a consensus phase. New tasks are included in the timetable of each agent by comparing the estimated start time of tasks placed by its own and other agents during the timetable construction phase. Then in the consensus phase, agents share their timetables with a communication network, and conflicts among their timetables are eliminated according to a consensus rule. Extensive simulation results show that the average start time of tasks of the proposed CBTA is nearly the same as the consensus-based bundle algorithm (CBBA) when performing single-agent tasks, and it is much less than the consensus-based grouping algorithm (CBGA) when performing multi-agent tasks with various communication network topologies.


The aim of this study was to develop a validated high-performance thin-layer chromatography (HPTLC) procedure for resolution of chemical constituents and identification and quantification of two selected natural anticancer compounds, stigmasterol (PD-1) and cinnamic acid (PD-2), in Pluchea dioscoridis chloroform fraction (PDCF). The chromatographic estimations were conducted on normal HPTLC (20 cm × 10 cm glass-backed silica gel 60 F254) plates with chloroform-methanol-acetic acid (93:5:2, V/V) used as the mobile phase. para-Anisaldehyde was used for the derivatization of the developed plate, and compact spots were scanned at λmax = 513 nm. A well resolved, compact, and intense peaks of PD-1 and PD-2 were recorded at RF = 0.57 and 0.19, respectively. The proposed analytical method for both biomarker compounds was found to be handy, simple, precise, linear (%RSD = 1.03–1.45), accurate (98.91–99.14%), reliable, and sensitive for the analysis of both biomarkers. The LOD/LOQ (ng) for PD-1 and PD-2 were recorded as 38.73/117.37 and 42.58/129.04, respectively, in the linearity range of 200–1400 ng per spot. The obtained result showed maximum quantities of PD-1 and PD-2 (5.36 and 16.98 μg mg-1, respectively). The developed HPTLC was found to be suitable for the routine analysis of these 2 biomarkers in the chloroform fraction of Pluchea dioscoridis and can be further employed in the process quality control of herbal formulations containing the said biomarkers.


Traditional analyses of aquaculture growth experiments usually consider only the yield at the end of the experiments and ignore the growth data collected during intermediato samplings. A multivariate model based on an expansion of the "Gulland and Holt Plot" used in fisheries biology provides a methodology to extract growth information from the data from intermediate somplings. This model is applied to data from three tilapia yield experiments conducted in seawater in Kuwait. The eITects of temperature, sex ratio and fish length on growth rate are quantified.


Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of early childhood with often fatal outcome. Despite many attempts to develop alternative treatment options allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative modality. In the past our group has linked the prognosis of JMML to differential DNA methylation patterns (Olk-Batz, Blood 2011;117:4871-80 and Poetsch, Epigenetics 2014;9:1252-60), suggesting a key role of epigenetic modifications in JMML pathophysiology. To overcome the lack of suitable preclinical JMML research models we have developed an ex vivo JMML xenotransplantation system using neonatal Rag2-/- gamma-c-/- mice. Transplantation of 1x106 primary JMML cells resulted in stable xenologous engraftment and reproduced a characteristic JMML phenotype including myelomonocytic expansion; infiltration of spleen, liver and, notably, lung; splenomegaly; and reduced survival (median 26 weeks). Persistent human engraftment and leukemic organ infiltration was confirmed by both flow cytometry and immunohistology. Ras pathway mutations present in xenotransplanted patient samples were invariably confirmed in engrafted tissues. In addition, the model sustained serial transplantations and can therefore be used to amplify scarce patient material. We first tested if DNA methylation patterns in JMML cells were stable even after xenologous engraftment because such stability would be a prerequisite if the model were to be used for preclinical investigation of DNA methyltransferase inhibitors. JMML cells before xenotransplantation and those retrieved from the bone marrow of engrafted mice were profiled for global CpG methylation using Illumina 450K arrays. DNA methylation patterns in JMML were patient-specific and surprisingly robust in functional regions over several months of engraftment time (on average, 0.29% of 30877 promoters and 0.25 % of 30725 intragenic regions were called as "differentially methylated" between source and xenograft; 0.2 β-value change cutoff). These findings confirm the suitability of the xenograft model to investigate JMML epigenetics and, more importantly, indicate that patient-specific epigenetic profiles originate in leukemia-initiating stem cells, reinforcing a fundamental role of these alterations in JMML biology. Our group recently published a retrospective case series demonstrating unprecedented clinical efficacy of the DNA methyltransferase inhibitor 5-azacytidine (5AC) to induce partial or complete remissions in JMML before allogeneic HSCT (Cseh, Blood 2015;125:2311-3). To further investigate the drug on the preclinical level we administered 5AC to Rag2-/- gamma-c-/- mice xenografted with primary JMML cells. After a leukemia establishment phase the mice were divided into treatment or mock groups and treated with 5AC (3mg/kg body weight i.p., N=6) or saline (N=6) for 2 cycles (1 dose daily for 5 days; 9 days of recovery). This regimen was tolerated well by the animals. We found that 5AC reduced JMML infiltration in all organs analyzed, with most pronounced effects in spleen (human CD45+ fraction of all CD45+ cells, 0.24% +/- 0.04% vs 39.78% +/- 10.72%; p In summary we created an ex vivo JMML xenograft model in immunodeficient mice that reflects many important aspects of this disorder and proved its usefulness for preclinical research of DNA methyltransferase inhibition because of extraordinary stability of leukemic DNA methylation patterns. 5AC showed clear preclinical efficacy in this model, supporting its further development in clinical treatment strategies for JMML. Disclosures No relevant conflicts of interest to declare.


provides a welcome contribution to currentdebates surrounding the field of social capital and public health.The authors provide, firstly, an analytical basis for discriminat-ing between the different stances; secondly, they outlinea theoretical framework for reconciling the polarized views;thirdly, they offer a historical perspective to support theirtheoretical framework; fourthly, they discuss the significanceof their thesis for social capital theory and public health, andlastly they provide a brief summary of the policy implications forpublic health arising from their own framework and the broadersocial capital literature. In doing all this, they have assembled animpressive range of literature to support their thesis.


Membrane fusion is an indispensable biological process that still needs additional study at the molecular level. Fusogenic viral envelope proteins that mediate viral entry into host cells are a useful tool to study the molecular biology of this process, and precise quantification of fusion events is needed for this purpose. A classical method, with limited precision, however, is to monitor formation of polycaryons as a result of cell-cell fusion by light microscopy (11). More sensitive are gene activation assays, and several modifications of this approach have been developed, most of them using β-galactosidase as a reporter (1,2,7,9). As an alternative approach, we describe here a new simplified assay using induction of the chloramphenicol acetyltransferase gene (CAT) as a sensitive indicator of cellular fusion events. In this system, two stably transfected human astrocytoma cell lines are used; both cell lines were derived from U373 MG (ATCC, Rockville, MD, USA). One cell line encodes a chimeric protein of the GAL4 DNA binding and herpes simplex virus (HSV) VP16 activation domains (including a GAL4 nuclear localization sequence) under the control of the simian virus 40 (SV40) early promotor. The other encodes five consensus GAL4 binding sites and the adenoviral E1b promotor upstream of the CAT gene. Fusion between these cell lines leads to transactivation of the reporter gene and is quantified by determination of CAT activity. Cell lines were established following liposome-mediated co-transfection (Life Technologies, Karlsruhe, Germany) of subconfluent U373 MG cells 24 h after seeding (9 cm petri dishes), using 10 μg of constructs pM3-VP16 or pG5CAT (both from CLONTECH Laboratories, Heidelberg, Germany) and 2 μg of pIG-1 (8), a plasmid coding for neomycin resistance. Two days after transfection, selection was initiated with geneticin (G418) at 800 μg/mL. Resistant clones emerging after 2–3 weeks were isolated and, in the case of U373 MG, transfected with the GAL4/ VP16 gene (U373-VP16). Expression was tested by western blotting with specific Polyclonal Antibody (CLONTECH Laboratories). Clones stably transfected with the CAT gene (U373CAT) were identified by cocultivation with U373-VP16 cells followed by polyethylene glycol (PEG)or virusmediated fusion. For this purpose, trypsinized cells were mixed at a ratio of 1:1 and seeded into 35-mm-diameter, 6-well petri plates to obtain a subconfluent monolayer the next day (106 cells). For PEG-mediated fusion, the Benchmarks


Objective:The purpose of this study was to investigate the two major start techniques in swimming competition through field research and literature review method.Method:The percentages of each start technique employed by 224 person-time swimmers in 14th FINA World Championship final match were surveyed.The start reaction(SR),the time on the 15m mark(start efficiency,SE),and score(SC) of all items(except 1 500 m) were analyzed.Meanwhile,the literatures related to swimming start technique in recent years were combed.Results:The percentage of track start(TS) technique employed by elite swimmers was increased from less than 40% a decade ago to 98% in the 14th FINA World Championship(2011).TS technique is superior to the grab start(GS).Conclusions:The GS technique would become a history and swimmers should master TS technique to acclimatize themselves to the appearance of the new platform with a booster.


Process transient stability simulation calculation based on power flow which uses the differ-ent accuracy of synchronous generator mathematical model in power system comprehensive program.And obtain transient stability through simulation examples in order to analyze and compare generator mathematical model in effects of transient stability study.


In the present study, we examined the effect of the loss of the human leucocyte antigen (HLA)‐B*3501‐restricted nucleoprotein (NP)418−426 epitope on interferon (IFN)‐γ‐production and lytic activity of the human cytotoxic T lymphocyte (CTL) response in vitro. Extensive amino acid variation at T cell receptor contact residues of the NP418−426 epitope has led to repeated evasion from specific CTL. We generated recombinant influenza viruses with variants of the NP418−426 epitope, which were used to stimulate peripheral blood mononuclear cells obtained from six HLA‐B*3501‐positive study subjects in order to expand virus‐specific CTL. Loss of the NP418−426 epitope resulted in a significant reduction of IFN‐γ‐expressing CD8+ T cells, similar to that observed previously after the loss of the HLA‐B*2705‐restricted NP383−391 epitope. In addition, the effect of the loss of the NP418−426 epitope on the lytic activity of the virus‐specific CTL response was assessed. Also this functional property of the virus‐specific CTL response was affected significantly by the loss of this and the NP383−391 epitope, as determined using the newly developed fluorescent antigen‐transfected target cell (FATT)–CTL assay. These findings indicate that the loss of single immunodominant epitopes affects the functionality of the virus‐specific CTL response significantly.


Yokohama, Japan, to host World's Largest Computer Graphics Event this December. The 2 edition of the highly anticipated ACM SIGGRAPH Conference and Exhibition in Asia will be held in the creative city of Yokohama, Japan, from 16-19 December. Positioned as the best educational platform in Asia, it is expected to draw over 8,000 industry luminaries and practitioners in the field of computer graphics and interactive techniques. This is also the event to be at for the newest technology, gadgets, hardware and software. SIGGRAPH Asia remains true to its SIGGRAPH tradition – this is where technology, art, culture, and science meet.


971 women who had recently delivered in a hospital were studied regarding their usage of family planning methods before the current pregnancy and their attitude toward the current pregnancy. It was observed that 25.5% were using some family planning methods and of these 84% were depending on their husbands condoms. A higher proportion among the users belonged to age group 25-35 parity 1-3 and socioeconomic class 1 and 3. A higher proportion of illiterate mothers were among nonusers (34%) compared with 9.6% among users. 44% of users were higher secondary and college educated compared with 28.2% of nonusers. Regarding husbands education 88.4% of users were higher secondary and college educated compared with 60.1% among nonusers. .4% of users were illiterate compared with 11.2% of nonusers. It was also observed that practice of family planning methods is related to the attitude toward current pregnancy whether it is wanted or not and that only 104 of the 599 mothers whose current pregnancies were unwanted are now practicing some method to prevent pregnancy.(AUTHORS MODIFIED)


Germination and root nodule formation of soybean (Glycine max) was evaluated in soil treated with Ridomil (R), Chlorpyriphos (CH), and a Combination of both (COM); using a completely randomized design, and a 3×3 factorial arrangement. Factor 1 was the pesticide type with 3 levels - R, CH, and COM; while factor 2 was the contamination rate (v/wt) with 3 levels - 0% (control), 2%, and 4%. Aqueous pesticides preparations (as recommended by manufacturers) were applied once, before seeds were planted. More than Ridomil and Combination, significantly (P<0.05) diminished percentage germination due to Chlorpyriphos was observed at 2, 3, and 4 weeks post application. The control had significantly higher germination than 2% and 4% groups, up until the 5th week. The Chlorpyriphos and pesticide Combination groups both had significantly lower root nodule number/plant, than Ridomil. Root nodule number/plant, and nodule biomass/plant were significantly reduced due to pesticide stress at 2% and 4%. Pesticides application at 2% and 4% negatively affected germination and root nodule formation; but there was no indication of an enhanced effect due to pesticides combination.


In the present work, formation of ice on a subcooled cylinder is experimentally investigated and mathematically modeled using heat transfer with phase change theories. A CFD model using COMSOL code was developed and validated with experimental results. Our model simplifies equations and corresponding solutions for a moving boundary phase change problem using two simple yet accurate assumptions and successfully alter a moving boundary phase change problem to a simple single phase transient heat transfer problem. This model endeavored to describe the freezing process for each study. The effect of many operating conditions like subcooling temperature on freezing rate and maximum ice width is simulated.


Purpose: Adoptive therapy with genetically engineered T cells carrying redirected antigen specificity is a new option for the treatment of cancer. This approach is not yet available for metastatic renal cell carcinoma (RCC), due to the scarcity of therapeutically useful reagents. We analyzed tumor-infiltrating lymphocytes (TIL) from RCC to identify T-cell specificities with shared tumor-specific recognition to develop T-cell receptor (TCR)-engineered T lymphocytes for adoptive therapy of RCC. Experimental Design: We established a T-cell clone from TIL that recognized a human leukocyte antigen (HLA)-A2–restricted tumor antigen. The TCR α- and β-chain genes were isolated, modified by codon optimization and murinization, and retrovirally transduced into peripheral blood lymphocytes (PBL). A TCR-expressing indicator line (B3Z-TCR53) was established to screen for antigen prevalence in RCC, other malignancies, and normal cell counterparts. Results: TCR53-engineered PBL recapitulated the specificity of the TIL and showed tumor-specific HLA-A2–restricted effector activities (IFN-γ, tumor necrosis factor-α, interleukin-2, macrophage inflammatory protein-1β, cytotoxicity). PBL-TCR53 of healthy donors and RCC patients exhibited similar transduction efficiency, expansion, and polyfunctional profile. Using B3Z-TCR53 cells, 130 tumor and normal cells were screened and shared TCR53 peptide: MHC expression was found in >60% of RCC and 25% of tumor lines of other histology, whereas normal tissue cells were not recognized. Conclusions: To date, TCR53 is the only TCR with shared HLA-A2–restricted recognition of RCC. It fulfills the criteria for utilization in TCR gene therapy and advances T cell–based immunotherapy to patients with RCC and other malignancies expressing the TCR ligand. Clin Cancer Res; 16(8); 2333–43. ©2010 AACR.


Fan Yunkuab the professor of Guangxi normal university college of liberal arts. In the 90 s after retirement,he devoted to the ancient poetry creation and research. He has published two books of poetry,poetry more than thousand income. He through these poems to express the poetic meaning. Its commendable poems rational,implicative,refined and full of stereo feeling,colour,rhythm,reveal rich aesthetic connotations.


Objective
To investigate the prevalence and major risk factors of nonalcoholic fatty liver disease (NAFLD) among adult health examination participants in Chengdu to provide reliable evidence for the control and prevention of the disease.

Methods
The clinical data, including age, gender, body mass index, blood glucose, total cholesterol, triglyceride, and B-ultrasound, were available in 12 152 adults health examination participants in Chengdu from June 2007 to February 2008.Questionnaire survey for details in life or work style was conducted.

Results
The prevalence rate of NAFLD of the subjects was 12.3%.The incidence of NAFLD in men was significantly higher than that in women (15.5% and 7.0%, respectively; P 60 years group, no different incidence was observed.The morbidity rate of NAFLD in men was significantly increased in those preferred mental labors, salty food, smoking, and no activities.The higher prevalence rate of NAFLD in women was correlated with light working pressure and salty food.The major accompaniment diseases of NAFLD were overweight or obesity, hyperlipemia, and fasting hyperglycemia.

Conclusion
The prevalence rate of NAFLD among adult health examination participants.The rate of NAFLD in men was significantly higher than that in women in Chengdu.NAFLD may be related with age, and its major risk factors include unhealthy life and work style.

Key words:
Fatty liver; Physical examination; Epidemiology; Risk factors


A number of the mesoionic compounds known as a new class of heterocycles have been examined in the search for potential therapeutic agents and their biological activities have been reviewed recently by Kier and Roche (1), and Ackermann (2). Oehme et al. (3) studied some mesoionic 3- or 3, 4-substituted sydnonimines and found that in urethane anesthetized rats the sydnonimines were hypotensive only in high doses (0.02 mM/kg i.v.), the effect not being pronounced, and reported that in the rat duodenum and the guinea pig ileum 3, 4-diphenylsyndnonimine had a spasmolytic effect equipotent to papaverine. However, no detailed cardiovascular actions of sydnonimines have so far been reported. Recently we found that the newly synthesized 3-substituted sydnonimines (4) have potential pharmacological actions such as vasodilating, vasoconstricting, hypotensive, hypertensive, sympathomimetic, or spasmolytic actions. This paper reports the chemical structureactivity relationship and mechanisms of the cardiovascular actions of 3-substituted sydnonimines, especially those of 3-morpholinosydnonimine hydrochloride (CV-664, SIN-1), a potent hypotensive and spasmolytic compound.


In the year 1861 I spent some time in examining the interval between the Red Marls and the Upper Lias in Central and Western Somerset, taking, in the course of my examination, upwards of seventy sections. The results of this exploration, so far as relates to the Rhætic beds and the White Lias, are embodied in the following paper. The suites of fossils collected, and numbered on the spot, have been examined by my friend Mr. Etheridge, F.G.S., without whose able assistance and corrections I should have felt diffident in my own determination of the Invertebrata.


The article views the nature and concept of the extended commercial concession agreement in the system of higher education in Russia. The authors determine the key prospects for cooperation between state universities and businesses in the conditions of the emerging knowledge-driven economy, and analyze both the contradictions appearing in the process of this interaction and strategic benefits, which partners and the society gain in general.


Cornsilk contains various beneficial phytochemical compounds. There are claims that cornsilk exhibits various biological activities in vivo. The aim of the present study was to determine the cornsilk bioactive compounds and the cytotoxicity effect of cornsilk extract on brine shrimp. Cornsilk was extracted using different solvents with single extraction procedures. All phytochemical compounds samples were identified via GC-MS equipment. The brine shrimp toxicity test was observed to obtain LC50 value for both extracts. Eleven compounds were identified in the aqueous extract of cornsilk (AEC) while methanolic extract of cornsilk (MEC) contained 4 compounds. These compounds consist of cyclopentane-ethyl, 2-methylheptane, furfural, furfuryl alcohol, furfuryl-5-methyl, 1-naphtol, lactone-G, cis-2-pentenal, pyranone, hydroxymethyl furfural and palmitic acid. There was only 1 similar compound found in both extracts which was the hydroxymethyl furfural. Cytotoxicity test showed that cornsilk is non toxic. The LC50 values found in AEC and MEC were 3151.34 and 1350.65, respectively. Our result found that cornsilk contained various bioactive compounds which positively supported most of the therapeutic activity claimed. In brief, the cytotoxicity test shows that cornsilk is non toxic for human consumption due to its high LC50 value.


Starting with the importance of sustainable utilization of the grassland resources in China, based on the analysis of its present utilization situation and ecological environments, the problems existed in grassland resources during developing and utilizing them were mainly discussed, and countermeasures were put forward further.


This article gives both the blue print for a 'dopt-lam' crate and the reasoning behind constructing such. These crates are designed as to facilitate the reduction of newborn lambs lives under conventional methods.


Keywords: Philosophie ; Epistemologie et histoire des sciences ; Section MA Reference EPFL-STUDENT-164080 Record created on 2011-03-06, modified on 2017-05-12


The Fractional Fourier transform is a useful mathematical operation that generalizes the well- known continuous Fourier transforms. It has been found wide applications in information processing, optical image encryption, beam analysis and shaping. In this paper operational calculus on the generalized two-dimensional fractional Fourier transform (2DFrFT) is presented.


703 of modernity and identity in Latin America should show them locked together in a paradoxical state of mutual antagonism and dependence, rather than alternating in prominence over the course of time. Such a view would also be able to account for the interesting fact that this oscillation frequently occurs within the work of one and the same writer, as the examples of Domingo Sarmiento and Paz demonstrate. Larrain's view is that Latin American intellectuals have presented identity and modernity as polar opposites. One of the principal aims of his book is to break down this opposition. He convincingly argues that modernity in Latin America ought not to be associated with "the acquisition of an alien identity (Anglo-Saxon, for instance)" (206). Indeed, the pursuit of modernity has been such a prominent aspect of Latin American history that it has become "an important part of the process of identity construction" (ibid.). There is, then, a specifically Latin American modernity whose features "constitute, for better or for worse, important elements of Latin American cultural identity" (ibid.). One cannot help noticing that Larrain often describes these features in terms of a lack or absence: "the lack of autonomy and development of civil society"; "the weakness of democratic institutions"; "the fact that Latin America has never had a welfare state" (193, 195, 199). Still, his argument that modernity is an integral part of the continent's own heritage—not a foreign imposition—is an extremely important one. It is an argument supported here by a profound respect for history, both as the accumulation of the past and as a realm of future possibility. For as Larrain points out in the closing pages of Identity and Modernity, even if the features of a Latin American modernity are part of Latin America's identity, "nothing prevents their critical appraisal or their change in the future" (206).


This study contains an analysis of personal injury accidents involving cyclists, as reported by the police, which occurred in Sweden during 1968 (a similar study on moped drivers is also being carried out). The aim of the study was to describe the accidents in detail. The study comprised 2015 accidents, 318 of which were of such a specific kind that they were analyzed separately. The latter category includes accidents in which one of the vehicles involved had some technical deficiency or the drivers were intoxicated. The remaining 1697 accidents occurred mostly in built-up areas and during the summer (April to September). One-third of the involved cyclists were children. The most frequent accident involved a cyclist and a motor vehicle. As many as 83% of the accidents belonged to this category. Accidents between a cyclist and a motor vehicle occurred mostly in built-up areas and three quarters of these at intersections. In 41% of the latter accidents the motor vehicle and the cyclist both travelled on the same road before the accident. Almost half of these accidents occurred at intersections when the motor vehicle and the cyclist were travelling on different roads before the accident, the two road users involved intending to cross the intersection without turning. At intersections with special priority rules, the cyclists broke these rules more often than the drivers of the motor vehicles. Some non-intersection accidents occurred when the cyclist turned left across the roadway in front of oncoming traffic. A large part - 45% - of the single-vehicle accidents in built-up areas occurred when a cyclist passed a parked car at the same time as the driver or a passenger of the car opened a door towards the roadway. /IRRD-IRF/


High up in the pantheon of British values—perhaps among those that the Conservative Government wants to be taught to children in schools—is our famed British sense of humour. Everybody, British and foreign, seems to agree that we are the funny man of Europe. If the notoriously humourless bureaucrats of Brussels were to create the post of EU commissioner for jokes, there is no doubt that the job would go to a Brit. Or perhaps: would have gone to a Brit. It is telling how much difficulty I have with tenses when talking about Britain and Europe. When someone has died, we have difficulty switching from the present to the past. Here, we are not sure whether Britain's membership of the EU has really gone, or whether it is still clinging on and might yet miraculously revive. As I write, the Government has yet to trigger Article 50. Britain's Europeanness is in a coma that we, the electorate, have induced, hovering, like Schrödinger's cat, between life and death, and no-one has dared open the box. It might, of course, be suggested that Britain has always occupied a threshold position in relation to Europe. But now, Britain is the European Union's old nag at the knacker's yard, dumbly waiting for the merciful bolt of Article 50. This situation—the zombification of Britain in Europe, one might call it—is likely to last for years and, in so many areas of public life, one can only begin to imagine its stultifying and uncanny effects. But, on an emotional level, it leaves one in limbo, not knowing whether one ought to be in mourning, not knowing whether to laugh or cry. Many Remainers (remoaners, as the pro-Brexit press now calls them) have already shed tears over Brexit. On the morning of the result, I took my children, as usual, on the District Line from their East London home to their school, the French lycée, in South Kensington. Sitting between them in a curiously tense and silent tube carriage, I had to explain to them— in French, quietly but with intensity—what had happened, why that decision went against values that their parents hold dear and values that they ought also to cherish, but also reassure them that their future would nonetheless be bright. Brexit for children. Coming from a middle-class household and with a privileged background, their future will be bright and, in practical terms, as young holders of both British and French passports, Brexit will affect them least of all. Certainly, their future will be brighter and be less materially affected by Brexit than the children of those working-class Leave voters in the post-industrial towns and cities of England and Wales who rightly felt that the modern world gives them a wrong deal


(57) based on the Abstract: polymerized type I collagen and / or type III collagen, compositions for medical applications as a vascular sealant and wound dressings, as well as its preparation is described. Prior to polymerization, the collagen monomers are prepared recombinantly, thereby the chemical modification of collagen to form such monomers is not required. Containing gelatin consisting of type I collagen and type III collagen, type I collagen and / or type III collagen composition medical medical adhesive for bonding the soft tissue as (medical Adhesive), and a variety of medical applications it is useful as a sealant for. In a further aspect of the present invention, I-type collagen and / or type III collagen composition was polymerized to provide the desired advantageous further features in including or tissue sealing or wound covering factors that induce wound healing. The compositions of the present invention are also useful in non-adhesive form.


The Advanced Space Propulsion Laboratory (ASPL) is developing a Variable Specific Impulse Magnetoplasma Rocket (VASIMR) using a Radio Frequency (RF) heated magnetic mirror operated asymmetrically. The system comprises of three stages: 1) plasma ionization and injection into the magnetic system; 2) ion heating by action of Ion Cyclotron Resonance Heating (ICRH); 3) plasma exhaust through a magnetic nozzle. The central experimental device is a small versatile tandem mirror configured system. The system can also be easily reconfigured to operate as a simple mirror. The total length of the device is 3.2 m, and the maximum magnetic field is 3.0 T. The exhaust end connects to a 5 m vacuum chamber where we are installing a 40,000 liter/second pumping capacity. Radio frequency power is available at approximately 3 MHz at up to 200 kW. A set of plasma diagnostics is being developed and installed, starting with two fast reciprocating probes, one quadruple Langmuir and one Mach. 2 We are now evaluating the use of a helicon 3 RF plasma source for an efficient ionization stage of the system. Initial results from experiments using a single double-half turn antenna are presented. In addition, we are exploring the use of a Lorentz Force Accelerator (LFA) as a plasma injector source.


This article renders the analysis of such a problem of full or partial change of person's gender-role characteristics that is expressed in gender representation. This happens when the necessity to present person's natural social gender becomes less eminent and one has possibility to choose his/her gender identity. Rational and non-rational reasons and gender representation factors are also introduced and basic types of gender representation are named.


The results of the surgical treatment of trigeminal neuralgia are brilliant and extremely gratifying to patient and surgeon alike. Section of the sensory root of the fifth cranial nerve offers immediate and lasting relief from an excruciating pain which defies description. Among an appreciable number of patients suffering from a true major neuralgia involving the trigeminal nerve there is a small number complaining of pain in the face which must be differentiated from typical trigeminal neuralgia. These patients offer a real differential diagnostic problem because surgical measures directed toward the fifth cranial nerve usually offer no relief. The history given is that of a deeply situated, dull ache occurring in one or more of the areas supplied by the divisions of the trigeminal nerve. It may be more or less continuous and attended by exacerbations, and it may spread from one divisional area to another. The important point to be


How to find most relative factor in multifactor system and how to find the function between relative factors and result are very important. In this paper, Bayes is used to find the most relative factors, then the training dataset is clustered by AGNES(Agglomerative Nesting) , then the section polynomial fitting is used to formulate multiple function for those most relative factors. Finally, this method is applied in the eye sight analysis system, and satisfying results can be obtained.


Process validation is the most important one of the validations done for pharmaceuticals manufacturing.According to the production practice of process validation,this paper summarizes some feelings and experiences what we learn about intervention time,validation strategy,validation risk management and implementation of the practices in process validation of blood products.


S)-tert-butyl 3-hydroxybutyrate was synthesized by asymmetric reduction of tert-butyl acetoacetate with Saccharomyces cerevisiae B5 as catalyst. The enantiometric excess of (S)-tert-butyl 3-hydroxybutyrate increased with addition of more amount of substrate. High optical purity of product can be obtained when 6 g/L chloroform was used as inhibitor. The optimum reduction time, temperature, and initial pH of reaction mixture were 60 h, 30 °C, and 6.2. Addition of more biomass and lower amount of substrate helped to get high conversion. Conversion and enantiometric excess of product reached 100% when initial substrate concentration and biomass were 2.0 g/L and 140 g/L with 6 g/L chloroform as inhibitor.


A simple method is used to calculate the contribution of the rapid rise in optical absorption near the absorption edge of semiconductors to the index of refraction near the edge. Other contributions to the index are also estimated. The results give qualitative agreement with the results obtained for PbS by Riedl and Schoolar, and very good agreement with Marple's prism measurements of the index for GaAs. Some applications to injection lasers are discussed. The temperature and pressure dependence of the index of refraction near the absorption edge is estimated, and agrees well with experimental results for GaAs.


Vaginal cuff dehiscence and small bowel evisceration after laparoscopic radical cystectomy, although rare, can be a critical complication. However, little has been reported about it by urologists.


One of the key implications of the Markowitz "mean-variability" approach to portfolio selection arises from Sharpe's extension to a theory of capital market equilibrium. His model implies that a single measure of each security's "systematic risk," or tendency to fluctuate with the market, provides, under the assumption of homogeneity of investor expectations, all necessary information about it for selecting an optimal portfolio. That is, instead of knowing the standard deviations of predicted return for all securities and their covariances with other securities, an investor need only know each security's systematic risk, referred to as volatility' in this paper, and the expected return and standard deviation of the market as a whole. This paper suggests that some of the assumptions of Sharpe's capital market theory under agreement are not essential for the derivation of a similar measure, termed market similarity, under a statepreference theoretic approach. The Markowitz and Sharpe models are first reviewed, and their implications for the measurement of volatility are shown. Then, a model of capital markets in a state-preference context is developed, and the corresponding capital market line is derived. Finally, the analogue of volatility is proposed. This measure has the property that, under investor agreement regarding state probabilities, it is identical with volatility for all securities on the state-preference capital market line. Under less restrictive assumptions it is shown to preserve some of the properties of volatility.


To review the literature on depression in cancer patients with a particular focus on depression assessment and barriers to mental health treatment in older cancer patients.


IntroductionAfter service quality and satisfaction, value was recognized as the third factor with significant impact in future intentions (Cronin, et al., 2000). As service quality and satisfaction were considered key factors for services organizations, they were investigated in depth for quite some time (Martinez, Ko & Martinez, 2010), while value attracted the interest of sport researchers during the 90's (Al Sabahy, Ekinci & Riley, 2004) and since then it has been recognized as one of the most successful and competitive strategies (Grοnroos, 1994). According to Al Sabahy et al., (2004), value gained recognition because it does not only affect the customers' decision making process prior to the purchase of service but also their satisfaction and intention to repeat purchase in the future (Parasuraman & Grewal, 2000). As it is vital for sport organizations to retain their customers and, if possible, predict their future behavior it is considered essential to investigate value in the sport spectators' area as well.Undoubtedly, soccer is the most popular sport and attracts the interest of a huge number of fans who identify themselves with the sport, many of whom attend games regularly. In Greece, soccer, until recently, was funded by government recourses, while management and marketing were not as developed as they were internationally (Thamnopoulos & Anestos, 2003). Lack of management and marketing practices and unsafe conditions during the games, have led to a decreased number of fans attending football games year by year. So, the challenge for the Greek managers of sport facilities and by extension of professional soccer organizations is to identify factors which can significantly influence customers future intentions and behavior in order to retain their existing customers or even to attract new ones. Specifically, if the effect of factors that can mainly be controlled by management, such as value, can predict satisfactorily the repurchase intention and the word of mouth, then management need to move in this direction.Review of LiteratureValueThe notion of perceived value lias gained interest among the researchers because of its mediating role satisfaction (McDougall & Levesque, 2000). The most common definitions of value referred to analogy (comparison) between quality and price (Monroe, 1990). Zeithaml (1988), proposed that value is a general evaluation of customers, regarding the usefulness of a product or a service based on what they take and what they give in order to obtain it. This model suggests that other factors apart from money (price) must be taken into account such as time spend, searching costs, emotional costs, etc. According to Ravald and Grοnroos (1996), the ability of organizations to offer value is a precondition to establish long-term relationships with their customers. Value not only has an important impact after the purchase, but also affects the decision making process (Dodds Monroe, & Grewal 1991).Future IntentionsThe most common future intentions referred in bibliography are the intention to communicate the experience of the use by word of mouth and the intention to repurchase the product / service.Word-of-Mouth CommunicationWord-of-mouth (WOM) is probably the oldest means of exchanging opinions on products and services offered by various organisations (Goyette, Ricard, Bergeron, & Marticotte, 2010). WOM is usually defined as an exchange, flow of information, communication, or conversation between two individuals. Many authors agree that WOM is an informal and noncommercial conversation. In the early 1970's, studies suggested WOM was nine times as effective as advertising in converting unfavorable or neutral predispositions into positive attitudes (Day, 1971).Studies on WOM have demonstrated that its effectiveness is based on the overwhelming influence that it has on consumer behavior. Researchers have shown that WOM was strongly and positively associated with service quality (Harrison-Walker, 2001; Parasuraman, Zeithaml, & Berry, 1988), satisfaction (Anderson, 1998), perceived value and with customer's repurchase intention (Hartline & Jones, 1996). …


The invention discloses a construction method for a brick setting concrete steel tie anti-crack plate strip, and belongs to one construction technology in the field of building. The construction method comprises the following construction technological processes: step a, conducting paying off and leveling, and arranging a height pole; step b, positioning a steel tie bar; step c, planting the steel tie bar; step d, conducting masonry on a wall, and installing clamps; step e, installing and shaping formworks; step f, pouring concrete, wherein the step b-step f can be repeated continuously after the step f, and when the step e is repeated, the formworks obtained in the last step e can be disassembled to be repeatedly used. The construction method is easy to implement, high in steel tie strength, firm in masonry structure and good in durability, the common quality problems of wall cracks are solved, and the construction method is quite suitable for construction of industrial and civil building framework infilled walls.


Background: Studies of adults have shown a direct association between increased serum concentrations of high‐sensitivity C‐reactive protein (hs‐CRP) and atherosclerotic cardiovascular disease, diabetes, and chronic heart failure. Some studies have documented elevated hs‐CRP in obese children and adolescents, and in patients with a history of Kawasaki disease, but there are few data on its clinical significance in congenital heart disease.


The paper firstly puts forwords the definition of administrative economic coordinated development.Secondly from economic relation,economic growth and economic disparity the paper builds its evaluating index.Then the paper analyzes spatial pattern and evolution about administrative economic coordinated development degree of China with city administrative units.The paper shows main conclusions as(1) The degree of administrative economic coordinated development in most provinces of China is low.Developed provinces have higher degree of administrative economic coordinated development and developing provinces have lower one.(2)East region of China has the highest degree of administrative economic coordinated development.Then orderly there are middle region,west region and east-north region.The degree of administrative economic coordinated development in east region keeps on the level of 0.6.And it keeps on the level of 0.3,0.2,0.1 according to middle region,west region and east-north region.(3) From the evolution of spatial pattern,the provinces which transfer up mostly belong to east region and only a few belong to west region.On the contrary the provinces which transfer down mostly belong to west region and only a few belong to east region.Accounted for 60% of the whole nation remain unchanged.


Objectives Efforts to scale-up maternal and child health services in lower and middle income countries will fail if services delivered are not of good quality. Although there is evidence of strategies to increase the quality of health services, less is known about the way these strategies affect health system goals and outcomes. We conducted a systematic review of the literature to examine this relationship. Methods We undertook a search of MEDLINE, SCOPUS and CINAHL databases, limiting the results to studies including strategies specifically aimed at improving quality that also reported a measure of quality and at least one indicator related to health system outcomes. Variation in study methodologies prevented further quantitative analysis; instead we present a narrative review of the evidence. Findings Methodologically, the quality of evidence was poor, and dominated by studies of individual facilities. Studies relied heavily on service utilisation as a measure of strategy success, which did not always correspond to improved quality. The majority of studies targeted the competency of staff and adequacy of facilities. No strategies addressed distribution systems, public-private partnership or equity. Key themes identified were the conflict between perceptions of patients and clinical measures of quality and the need for holistic approaches to health system interventions. Conclusion Existing evidence linking quality improvement strategies to improved MNCH outcomes is extremely limited. Future research would benefit from the inclusion of more appropriate indicators and additional focus on non-facility determinants of health service quality such as health policy, supply distribution, community acceptability and equity of care.


Objective To study the status of KAP about chronic diseases of residents from20 to 50 years old in JiNing city and the influential factors,so as to provide scientific evidence for the government to make chronic disease prevention and control measures.Methods Use the questionnaire designed by myself to investigate 400 residents from20 to 50 years old selected by the multi-stage sampling method.Results The average score of knowledge about chronic diseases was 68.53±21.34.The pass rate was 61.4%.Between different gender,age,occupation,educational level,and place of residence,the differences were statistically significant(P0.05).There was a positive correlation between chronic diseases KAP.KAP level was positively related to gender and education level.Conclusion The knowledge and behaviors associated with chronic diseases need to be improved.The government should strengthen the propaganda and education to improve the residents' health literacy,and promote the prevention and treatment of chronic diseases in Jining city.


All-solid-stated pH sensors based on metal/ metal oxide were widely used in mixed heterogeneous environment, such as soil or soilless cultivation. In this study, an all-solid-stated pH sensor prepared by magnetron sputtering was presented, of which the working electrode was antimony, and reference electrode was Ag/AgCl electrode, and heat treated process was conducted to improving the performance of all-solid-stated planar pH sensor. The electrodes heat treated at the temperature of 100°C, 200°C, 300°C, and 400°C were tested through surface morphology analysis, energy spectrum analysis and electrochemical experiments. The results showed that the heat-treated temperature had a remarkable effect on the performance of the pH sensor. Specifically, the pH sensor heat-treated at 200°C had excellent performance, with the sensitivity 74.0 mV/pH, the response time less than 3 s, the standard deviation less than 2 mV in 700 s period. The developed sensor can be applied in pH detection in soilless culture and is promising to popularize in industrial production.


Convection is the most important physical process that determines the structure of the envelopes of cool stars. It influences the surface radiation flux and the shape of observed spectral line profiles and is responsible for both generating and damping solar-like oscillations, among others. 3D numerical simulations of stellar surface convection have developed into a powerful tool to model and analyse the physical mechanisms operating at the surface of cool stars. This review discusses the main principles of 3D stellar atmospheres used for such applications. The requirements from stellar structure and evolution theory to use them as boundary conditions are analysed as well as the capabilities of using helio- and asteroseismology to reduce modelling uncertainties and probing the consistency and accuracy of 3D stellar atmospheres as part of this process. Simulations for the solar surface made by different teams are compared and some issues concerning the uncertainties of this modelling approach are discussed.


Introduction, Roger A. Mason John Knox and the historians, James Kirk. Part 1 Early years and exile: John Knox and the castilians - a crucible of reforming opinion?, Carol Edington Frankfurt and Geneva - the European context of John Knox's reformation, Euan Cameron John Knox, the Church of England and the women of England, Patrick Collinson. Part 2 Political and theological thought: John Knox and the early church fathers, David F. Wright Knox - scholastic and canonistic echoes, J.H. Burns trumpeting resistance - Christopher Goodman and John Knox, Jane E.A. Dawson Knox, resistance and the royal supremacy, Roger A. Mason playing God's card - Knox and fasting 1565-66, W. Ian P. Hazlett. Part 3 The Scottish reformation: Knox, Cecil and the British dimension of the Scottish reformation, Stephen Alford godly minister, godless monarch - Knox and Mary Queen of Scots, Jenny Wormald Knox -minister of Edinburgh and commissioner of the Kirk, Michael Lynch Knox on discipline - conversionary zeal or rose-tinted nostalgia?, Michael F. Graham.


Abstract. Circum-Arctic permafrost stores large amounts of frozen carbon that must be maintained to avoid catastrophic climate change. Solar geoengineering
has the potential to cool the Arctic surface by increasing planetary albedo but could also reduce tundra productivity. Here, we improve the
data-constrained PInc-PanTher model of permafrost carbon storage by including estimates of plant productivity and rhizosphere priming on soil
carbon. Six earth system models are used to drive the model, running G6solar (solar dimming) and G6sulfur (stratospheric sulfate aerosols)
experiments, which reduce radiative forcing from SSP5-8.5 (no mitigation) to SSP2-4.5 (substantive mitigation) levels. By 2100, simulations indicate
a loss of 9.2 ± 0.4 million km2 (mean ± standard error) of permafrost area and 81 ± 8 Pg of soil carbon under the
SSP5-8.5 scenario. In comparison, under SSP2-4.5, G6solar, and G6sulfur, permafrost area loss would be mitigated by approximately 39 %, 37 %,
and 34 % and soil carbon loss by 42 %, 54 %, and 47 %, respectively, relative to SSP5-8.5. Uncertainties in permafrost soil
C loss estimates arise mainly from changes in vegetation productivity. Increased carbon flux from vegetation to soil raises soil
C storage, while the priming effects of root exudates lowers it, with a net mitigating effect on soil C loss. Despite model
differences, the protective effects of G6solar and G6sulfur on permafrost area and soil C storage are consistent and significant for all
ESMs. G6 experiments mitigate ∼ 1/3 of permafrost area loss and halve carbon loss for SSP5-8.5, averting USD 0–70 trillion (mean of USD 20 trillion) in
economic losses through reduced permafrost emissions.


OBJECTIVE:To observe the safety and efficacy of second-generation recombinant factor Ⅷ (Kogenate FS) for treatment of patients with hemophilia A in China. METHODS: 16 patients with hemophilia A were treated with Kogenate FS. The factor Ⅷ antibodies and factorⅧ activities (FⅧ∶ C) were determined before and after the treatment. RESULTS: In the treatment of Kogenate FS for 16 patients with hemophilia A,15 (93.75%) recovered and 1 (6.25%) improved,and irreversible adverse drug reaction was seen in only 1 case. CONCLUSION: The second-generation recombinant factor Ⅷ product (Kogenate FS) was safe,efficacious and well-tolerated for patients with hemophilia A in China.


Aristotle's Categories had an unparalleled influence on the history of metaphysical speculation. Despite its influence, however, two fundamental questions remain to this day unanswered: (1) how did Aristotle generate his list of categories? and (2) what is the relationship between Aristotle's categories and his other great metaphysical system: hylomorphism? In this book, Paul Studtmann develops and defends an interpretation that offers a unified and striking answer to both questions: Aristotle's system of categories is systematically derivable from hylomorphism, which in turn is derivable from general theses about the nature of being.


Four photosynthetic bacteria, P1, P2, P3 and P4, were isolated from the sullage of hoggery cesspool and identified based on morphological character, capability of utilizing carbon sources and absorbency character of living cell. Results showed that P1 strain is Phaeospirillum molischianum, P2 strain is Rhodospirillum rubrum, P3 strain is Chromatium minus while P4 strain is Rhodobium orientis. Efficiency of sewage decontamination of these four strains were tested under laboratory conditions by method of measuring COD degradation rate. Strains P1 and P4 were found to degrade COD obviously, degradation rate is 55.2% and 72.1% respectively。


A highly nonlinear W-type erbium-doped fibre with high dopant concentration made of three lead silicate glass materials (Schott SF57, LLF1 and SF6) is presented. The fibre is designed to have a flat anomalous dispersion at ∼1.55 μm, which is critical for enhancing parametric wavelength conversion. With this fibre, signals at ∼ 1.55 μm are successfully amplified in continuous-wave and pico-second-pulsed formats with a 1.48 μm pump source. In particular, spectral broadening of over 350 nm together with strong degenerate four-wave-mixing effects is demonstrated. The authors highlight that this novel fibre combines, for first time to their knowledge, the benefits of highly doped active fibres with those of dispersion/nonlinearity-engineered fibres.


In this paper, the use of a biologically inspired spatial phased transducer array for the nondestructive evaluation of homogeneous and heterogeneous structural components is described. Beamforming of phased sensor/actuator arrays is achieved by applying weights and single time delays to the tapped signals in a manner analogous to the orb web spider that uses its legs to detect and locate its prey in a network of web fibers. Propagating bulk and surface stress/strain waves both inand out-of-plane are used to detect, locate and quantify material discontinuities along and within members. Experimental results on a composite plate help illustrate this method. Additionally, the advantages of adaptive array techniques are demonstrated using a Frost Constraint [1] based adaptive technique.


This study aims to determine how the knowledge and awareness of the community in the practice of debt and receivables that contain elements of usury. The method used in this research is a qualitative approach method with data collection used, namely data collection techniques by interview and documentation study. The results of this study are the practice of debt and receivables containing elements of usury carried out by some people due to a lack of knowledge and awareness in carrying out debt and credit practices regarding what usury is and what the impact of usury is, this happens because of a lack of attention from the local government which should hold socialization about how to practice money receivables that are allowed in Islam.


This study aims to figure out the level of mathematical resilience and mathematical problem-solving abilities of 11th grade sciences students in a senior high school. The subjects of the study were 63 senior high school students in 11th grade sciences, second semester 2018/2019 year who were studied at one of the senior high school in Baleendah, Bandung regency. This research method is a survey, in which the survey is included in one type of research is non experimental. The study design used is cross-sectional designs. There are two sorts of instruments used for this study, namely test and non-test instruments. Test instruments serve for measuring the level of mathematical problem-solving abilities of students, while non-test instruments are in the form of questionnaires, useful for measuring the level of mathematical resilience of students. The results showed that (1) the level of students' mathematical resilience is in the medium level, and (2) the level of students' mathematical problem-solving ability is in the medium level.