A Core‐Linker‐Polyamine (CLP) strategy has been exploited to develop new antileishmanial agents. It involves the linker‐based assembly of alkyl‐polyamine side chain as a potential pharmacophore motif with a privileged heterocyclic motif, 4‐arylquinoline. A series of aminoalkyl 4‐arylquinoline‐2‐carboxamides and their analogs were synthesized and tested against L. donovani promastigotes. Among all synthesized derivatives, 10 compounds showed significant antipromastigote activities with more efficacy (IC50: 4.75–8 μM) than an antileishmanial oral drug Miltefosine (IC50: 8.9±1.55 μM). Most active aminoalkyl‐quinoline‐carboxamides 9 a and 9 b, displayed negligible cytotoxicity towards human monocytic (THP‐1) macrophages. The compounds show antileishmanial activity by generating mitochondrial superoxide radicals. However, they did not show interference with trypanothione reductase, a redox enzyme of Leishmania. Significant change in the morphology of the L. donovani promastigote by the compounds was observed. The Structure‐activity relationship analysis suggest the pharmacophoric importance of alkylpolyamine and carboxamide motifs. In silico evaluation indicated that the investigated active molecules 9 a and 9 b possess important drug‐likeness, physicochemical and pharmacokinetic‐relevant properties.


Many malwares have the network activities for command and control, update, propagation, and so on. Because of the use of domain names while the network activities, those malicious activities are observed and have been blocked on the DNS. However, to evade static blacklists, recent malwares are using numbers of newly generated domain names. In this paper, we introduce a domain name grouping using DNS query graph containing query strategy of DNS clients. By grouping the domain names which have the statistically and sequentially similar query strategy, we extract the malicious domain names groups of the multi-domain malwares from the numerous numbers of domain names. From the experiments with the DNS trace of an ISP network, we find tens of multi-domain malwares, and commonly observed unique DNS query strategies. As the contribution of method, the grouping result enhances the efficiency of blacklists by detecting newly appeared malicious domain names.


This study aims to analyze the relationship between erosion, soil organic carbon content with land critical. This research uses a geomorphology approach with the landform as the unit of analysis. Land critical is determined by the grade level of erosion hazard and soil organic carbon content class, taking into account the value of the fraction of silt and clay. The result showed that erosion process can cause the land to become critical and uncritically. This is proven by the results of the research, showed that 43.49% is categorized as critical land, 25.99% very critical, 14.70% medium critical, 8.41% somewhat critical, and uncritical land 7.41% or widest 5461,89 ha from the total area of Girindulu Watershed. Therefore, it can be concluded that critical land is extremely depended on the process of erosion and soil organic carbon content.


Colombia has a hydroelectric power generation capacity of over 60% and thermal generation just above 30%. Smart Grids have as a common objective the reliability of the energy service and the economic growth using Information and Communication Technologies for the generation with minimum contributions of energy supply sources derived from fossil fuels. Therefore, some strategies are proposed for the implementation of components such as renewable energies, controlled loads, energy storage systems, electric vehicles which are managed by an aggregator, besides considering the uncertainty in the Colombian environment that includes climatic conditions, the prediction of user load and market prices. Smart Grids requires flexible management of loads in collaboration with users, it depends on their habits and control of charges (smart households). Energy storage is a tactic to control user loads and generation with non-conventional renewable energy. As energy storage methods are presented adapted to regional conditions.


In this paper, applications of the boundary element method to damaged and undamaged aircraft curved panels with mechanical repairs are presented. The effects of fastened repairs are replaced by uniform distribution forces in the area of cross-section of the rivet and can be determined from the compatibility condition of displacements. A coupled boundary integral formulation of a shear deformable plate and two dimensional plane stress elasticity is used to determine the bending and membrane forces on the rivets. Domain integrals in each integral equation are determined using the dual reciprocity method. The stress intensity factors due to bending and membrane loads are evaluated by opening displacements near the crack tips. Several numerical examples are presented to demonstrate the accuracy of the proposed method. It is shown that the bending behavior and plate curvature have significant influence on the magnitude of the stress intensity factors. keyword: Fracture, fastened repair, boundary element method, shell, stress intensity factor. Notation a half–length of central crack or length of edge crack cKαβ;c V ik jump terms Dm number of rivets on the patch m E Young's modulus F β ;F ml β concentrated forces in rivets f m β ; f m β applied body forces for plate and patches H height of plate h;hm thickness of plate and patches 1 Department of Engineering, Queen Mary and Westfield College, London University, London, E1 4NS, UK 2 Structural Materials Centre, DERA, Farnborough, Hants, GU14 6TD, UK Kbend k ;K mem β bending and membrane stress intensity factors KI ;KII;KIII stress intensity factors along thickness kαβ curvatures H;G;D coefficient matrices of BEM L number of nodes on the boundary or number of rivets in the domain Mαβ;Qα components of moment and shear for bending Nαβ components of membrane forces N0 applied tension load p fastener's pitch pk traction on the boundary for bending Q ml β ;Q ml β concentrated forces in rivets qk ;q m k applied body forces for plate and patches q0 uniform pressure load Tαβ fundamental solution of traction tβ traction on the boundary for two dimensions Uαβ fundamental solution of displacement uα displacements of two dimension elasticity xk coordinate system x collocation point on the boundary X domain point W width of plate wk rotations and deflection of plate bending Γ boundary of plate Ω domains Φ diameter of rivet ΦK ;ΦV coefficients of rivet ∆uα;∆wk discontinuities of displacements on crack surface σ0 uniform tension ν Poisson's ratio 2 Copyright c 2002 Tech Science Press CMES, vol.3, no.1, pp.1-10, 2002


Ž . Let U G be the quantized enveloping algebra associated to the Lie algebra e Ž . G s sl n q 1 at a pth-root of unity « and assume that p is a prime which does not divide n q 1. It is known that the irreducible, finite dimensional representaŽ . tions of U G are parametrized, up to isomorphisms, by the conjugacy classes of « Ž . Ž . SL n q 1 . In the paper we prove that the dimension of any U G -module M « parametrized by a conjugacy class O is divided by p1r2 dimŽO .. This result was Ž conjectured by C. De Concini, V. G. Kac, and C. Procesi J. Amer. Math. Soc. 5, . 1992, 151]190 . Q 1998 Academic Press


The identity and diversity Symbiodinium spp. of scleractinian corals are valuable to understand the response of reef ecosystems to environment change. The molecular taxonomy and genetic diversity of Symbiodinium of scleractinian coral were studied by specific amplification and sequencing of 28S rDNA, which belong to 5 families, 9 genera and 15 species in Daao Bay, Shenzhen. The 28S rDNA sequence of Symbiodinium from 45 samples of scleractinian corals was obtained by direct PCR sequencing. The molecular phylogenetic tree was constructed by using the method of Neighbor-Joining (NJ). The Symbiodinium of reef coral in Daao sea area of Shenzhen could be divided into two groups of Symbiodinium. Among them, 11 species belong to group D and 4 species belong to group C, and the average contents of G+C base and A+T base of 28 s rDNA gene of reef coral Symbiodinium in this area are similar. The results showed that the gene evolution rate of 28 s rDNA was fast, which was suitable for the identification of coral reef coral Symbiodinium community. The ability of light utilization and resistance of reef coral Symbiodinium in Daao sea area were strong, but the diversity is low. It suggests that the symbiotic system of reef coral Symbiodinium is fragile and poor resistance to external environmental pressure in this area. This single Symbiodinium with the scleractinian coral strategy may be an adaptation to the environment stress in this area.


Utilization of Waste Products in the Potato Processing Industry.

1. Wastes from Norwegian potato starch plants have been analyzed. The composition found is summarized.

2. An alkohol plant has been constructed to utilize the wastes from a potato starch factory. Later on this alkohol plant has been modified to utilize the wastes of a potato flake plant and a potato chips line.

To make profitable use of the wastes, they have to be collected and concentrated. A system for this purpose is indicated. The mash of the alkohol plant is prepared in a continuous tube system. The fermentation and distillation are carried out in a conventional equipment.

3. A pilot plant for the removal of water from potato fruit water by evaporation has been built and tried out. The concentrate from the evaporator was dried in a Rotadisc dryer with waste pulp as carrying material and used in mixed feeding-stuffs.


The absorption spectra of H2O2 and of HO2 radicals have been investigated in shock waves at 1950 ⩽ λ ⩽ 2900 A and temperatures of 650 and 1100 K. By comparison with room temperature experiments, information on the nature of electronic transitions involved may be obtained.


SUMMARY This paper presents a new numerical technique for modelling wave propagation in media with both fluid (acoustic) and solid (elastic) regions, as found for instance in a marine seismic case. The scheme can correctly satisfy the fluid‐solid interface conditions and accurately models the arbitrary interface topography. This work is an extension of the grid method, which is able to model wave propagation in heterogeneous solid (elastic) media with arbitrary surface topography and irregular interfaces. The scheme is developed by formulating the problem in terms of displacements in elastic regions and pressure in acoustic regions with an explicit boundary between them. The fluid‐solid interface conditions on this explicit boundary are implemented by introducing an integral approach to the fluid‐solid interface conditions. The solution in terms of pressure in acoustic regions together with this integral approach means that no extra computational cost is needed to implement the fluid‐solid interface conditions for a complex geometry, instead of resulting in additional computations as with the spectralelement, finite-element or finite-difference methods. In this paper an acoustic grid method is developed to solve the acoustic problem inside the fluid, and the (elastic) grid method, which is improved based on a parsimonious staggered-grid scheme, is used to solve the elastic problem inside the solid. The numerical dispersion and stability criteria for the acoustic grid method are discussed in detail. Comparison with an analytical solution demonstrates that the proposed scheme handles the fluid‐solid interface conditions correctly. Examples of wave propagation in a mixed fluid/solid model with both weak and strong sinusoidal fluid‐solid interfaces illustrate the suitability of the proposed scheme for modelling wave propagation across fluid‐solid interfaces with complex geometries.


Abstract The dynamical theory of electron diffraction including a term to take account of absorption has been applied to explain some contrast anomalies observed at extinction contours and stacking faults on transmission electron micrographs of metal foils. The theory is at present phenomenological because the detailed mechanism of the absorption process is not understood. This paper reports some preliminary results of the theory and compares them with observations.


Ultrawideband (UWB) technology applied in indoor localization systems is able to offer centimeter-level error in position measurement and attracts increasing popularity in various solutions. Position estimation is calculated based on ranging measurements between mobile nodes and anchors at known locations. Most existing works employ UWB in positioning context and resort to nonline-of-sight optimization imposed by static indoor building layout. In tracking applications, the direct path of UWB propagation may be obstructed by humans (pedestrians), which leads to significant ranging errors. It is observed that the ranging errors vary with respect to the degree of obstruction imposed by the pedestrian. In this paper, a UWB ranging error model with respect to the human body shadowing effect is proposed and evaluated by extensive measurements and experiments. The error model is applied in a particle filter pedestrian tracking algorithm fusing heading information obtained from an iPhone 7 built-in gyroscope. The performance of the proposed model outperforms the state-of-the-art approaches and has achieved up to 41.91% reduction in mean 2-D position error compared to the trilateration-based method in a pedestrian tracking case study.


Abstract : This report describes the development and testing of an Emergency Position Indicating Radio Beacon (EPIRB) which operates on Channels 15 and 16 of the Maritime Mobile VHF Band. It provides functions necessary to ensure that distress alerting and locating can be quickly and reliably provided for small craft in distress, in coastal maritime regions. When energized by a person in distress, the EPIRB will emit a radio signal which alternates between Channels 15 and 16 using international distress tones for modulation. Between transmissions, the EPIRB will turn off so as to conserve battery power. The EPIRB has been tested under actual distress conditions. It has been demonstrated to provide a reliable distress alert to Coast Guard stations within a range of 20 nautical miles. (Author)


Myth 1: Tobacco is only an issue for affluent people and affluent countries. Fact: Within individual countries, tobacco consumption and tobacco-related disease burdens are generally greatest among the poor. Smoking is declining among males in most high-income countries. In contrast, it is increasing in males in most lowand middle-income countries and in women worldwide. In China and Russia, smoking prevalence among men is estimated at 60%. The World Health Organization analyzed the increased smoking prevalence of women worldwide in its new publication Gender, women and the tobacco epidemic (available at http://www.who.int/tobacco/publications/gender/women_tob_epidemic/en/index.html).


The University of Illinois Center for Simulation of Advanced Rockets addresses the com- putational simulation of solid propellant rockets from first principles. Using a highly inte- grated structure/fluid/combustion interaction code, Center research faculty and staff have simulated a number of commercial and military solid propellant vehicles. This paper over- views the CSAR approach and recent successes. Other papers in this session will present de- sign details and results of subscale and full-scale rocket motor simulations.


An Introduction to the Immune Function of Thymus, Lymph Node and Spleen. The Thymus Gland. Lymph Nodes. Lymphadenitis Caused By Infection and Infestation. Sarcoidosis and Other Varieties of Granulomatous Lymphadenitis of Uncertain Cause. The Spleen. Neoplastic Disorders of Lymphoreticular Tissue. Immunostanding in the Diagnosis of Lymph Node Pathology. The Lymphatic Vessels. Index


In double sideband (DSB) AM broadcasting two sidebands carry the same information. Indeed one sideband signal is enough to recover the baseband signal at the receiving end. Hence one of the sideband can be cut out from the DSB signal and is commonly known as single sideband (SSB) signal. Other than only transmitting one sideband signal, two different information carried in the individual sideband can be applied in the AM broadcasting to replace the DSB AM one. As a result only one carrier is necessary to transmit and receive two different kind of information. Not only the bandwidth efficiency is enhanced but also a useful multipurpose broadcasting system is established. In this paper independent sideband (ISB) AM broadcasting system for audio and information transmission is proposed and tested.


This paper inquires into beginnings of a gift economy as well as related contemporary institutions. Gift economy and the gift as a complex phenomenon was a common base for institutions of markets, credits, taxation, alms or social security. Inquires of origins, development and contemporary forms are consequently important contributions to our understanding to contemporary social institutions. We can also inquire with economists into present forms of a gift and look for reply to different questions about efficiency of a gift: Why to give, how to give and what way give a gift.


VO2 polymorphic nanoparticles (NPs) were synthesized by hydrothermal reaction in the presence of surfactant bis(2-ethylhexyl) sulfosuccinate sodium salt (AOT). The AOT acts as both growth inhibitor and soft template in the formation of VO2 polymorphs, and there is a definite phase evolution process with prolonging reaction time: (NH4)2V6O16·1.5H2O → NH4V4O10 → VO2(B) → VO2(B+D) → VO2(D) → VO2(D+P) → VO2(P). The formation mechanisms of the VO2(D) and VO2(P) phases were found to be, respectively, a dissolution–recrystallization and recrystallization process. The as-prepared VO2(P) can be easily transformed to VO2(M) NPs after a mild annealing treatment, and the VO2(M) composite films show an excellent infrared performances. The clarification of phase evolution of VO2 polymorphs during hydrothermal treatment can help in understanding the formation mechanism and selective synthesis of different VO2 metastable phases.


This article approaches Carmen's myth to consider his structure, framed and mixed between fiction and erudite essay, valuing it like succeeded aes- thetically, on having understood it like proper of the topic and the erudition of a French traveler of the XIXth century on Spanish writer of folk literature and on the gypsies, in particular; world in which the violent death was settling the matters of love and jealousy and under which there beat the ancient myths of the woman as harmful force.


a high performance gas chromatography method has been developed for determining 20 kinds of organochlorine pesticides including α-BHC and 4,4'-DDT in American ginseng(Panax quinquefolium L.) grown in different areas of GAP plantation base from Liuba county,shaanxi province.The accumulation of organochlorine pesticides in American ginseng with different ages was also explored.Organochlorine pesticides in samples were extracted by hexane-ethyl acetate(1:1) solution,and then purified by a column packed with Florisil using hexane-ethyl acetate(1:1) as elution solvent.Chromatographic analysis was performed on a DB-17 capillary column supplemented with electron capture detector(ECD).A total of 19 organochlorine pesticides except for endrin were detected.The contents of organochlorine pesticides in samples from different areas revealed an obvious difference.Moreover,the residues of organochlorine pesticides in four-year-old American ginseng were higher than those in three-year-old or five-year-old American ginseng.Therefore,this developed method is effective,fast and accurate,which can be used for determining 20 kinds of organochlorine pesticides in American ginseng.


ABSTRACT
Melipona fasciculata Smith, a native species from Maranhao, collects resinous material from
the plants and brings to its hive, a mixture with salivary secretions, wax and clay or earth
forming the geopropolis. The objective of this work is to investigate the in vitro antitumor
activity of the hydroethanolic extract of the geometry of Melipona fasciculata, the cellular
molecule of ovarian cancer (ES2) and its chemical composition. The geopropolis of Melipona
fasciculata was collected in the municipality of Pinheiro, Maranhao. It was extracted by
maceration with 70% ethanol for 48 hours, filtered and concentrated in a rotary evaporator, and
then lyophilized, obtaining the hydroalcoholic extract of Pinheiro geopropolis (EHGP).
Polyphenols and total flavonoids were quantified. The antioxidant activity was evaluated by the
DPPH (2,2-diphenyl-1-picryl-hydrazyl) and FRAP (Ferric Reducing Antioxidant Power)
method. The chemical composition was evaluated by thin layer chromatography (CCD), high
performance liquid chromatography coupled to visible ultraviolet detector (HPLC/UV-Vis) and
high performance liquid chromatography coupled to mass spectrometer (HPLC/MS/MS).
Cytotoxicity was assessed by the MTT (3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyl-tetrizoline
bromide) assay. The EHGP presented extractive yield of 12.60%, with contents of phenols and
flavonoids, respectively, 7.27 ± 0.26% and 0.13 ± 0.01%, antioxidant activity by DPPH with
EC50 of 265.91 ± 0,29 μg/mL and ferric reduction capacity of 1.10±0.25 mmol Fe2+/g. The
chemical composition by HPLC/UV-Vis demonstrated the predominance of low polarity
compounds at the retention times from 40 min. The CCD revealed the presence of triterpenes.
Five compounds were identified by LC/MS/MS: gluconic acid and four phenolic compounds:
S-eriodictiol-6-C-β-D-glucopyranoside, narigenin-C-glycoside, isomer of narigenin-Cglycoside
and hesperetin-7-O-rhamnoside. The EHGP presented dose-dependent and timedependent
cytotoxicity in the ovarian cancer tumor line (ES2). Thus, the geopropolis is a
promising natural product in the search for bioactive molecules with anticancer potential.
Isolation studies and identification of biomolecules related to antitumor activity and toxicology
are required to determine the safety of this product which may be an alternative/complementary
therapy for the treatment of ovarian cancer.


The Eyre Sub-basin is situated in the Bight Basin in the Southern Margin. It covers an area of approximately 8,000km2. It is one of several half-graben in the Bight Basin that formed during the initial rifting between Australia and Antarctica. Sediments have accumulated in these depocentres from the Middle Jurassic to present. The initial environments of deposition were a series of fluvial, lacustrine and floodplain sequences before becoming open marine environments in the Cretaceous to Recent. Structural, Property and Reservoir Facies Models were created using the seismic interpretation and well logs from Jerboa-1. The models suggest the sequences on the Jerboa high thicken down-flank away from the well. Source rocks capable of generating hydrocarbons complete with oil stains and oil inclusions were found in the Middle Jurassic-Early Cretaceous non-marine sequences. There are several potential stacked reservoir sections in the sequences from the Middle Jurassic to the Berriasian. These have high porosities between 14-30% and clean channel sands as indicated on the Jerboa-1 logs. The Valanginian-Barremian shale dominated sequence is mapped as laterally extensive and has the best potential of sealing the underlying reservoirs. Across fault seal assessment indicates the fault throws potentially seal the reservoirs, although fault reactivation in the Late Cretaceous resulted in a collapsed graben complex along the apex of the Jerboa high and is potentially the cause of the hydrocarbons escaping. Sections in the Eyre Sub-basin that have stacked channel reservoirs, source rocks with adequate burial and traps that have not been breached have the potential to hold an accumulation of hydrocarbons. The Eyre Sub-basin is a working petroleum system.


This paper discusses a three-player conflict in which a missile intercepts a target while avoiding a defender launched by the target, all having bounded controls. Unlike linearized kinematics, the present approach adopts full three-dimensional vector kinematics suitable for an exoatmospheric engagement. In particular, time to go is calculated using a recently developed, game theoretic nonlinear feedback equation, leading to a guaranteed miss strategy and to simple sufficient conditions for the missile to intercept the target while avoiding the defender.


Let D ⊂ ℝn be a bounded domain with piecewise-smooth boundary, and q(x,t) a smooth function on D × [0, T]. Consider the time-like Cauchy problem

Given g, h for which the equation has a solution, we show how to approximate u(x,t) by solving a well posed fourth-order elliptic partial differential equation (PDE). We use the method of quasi-reversibility to construct the approximating PDE. We derive error estimates and present numerical results.


Resonance cavities in accelerators allow accelerated particles to reach velocities close to the speed of light. Niobium on Copper thin film sputtered cavities are a cheaper alternative to Niobium bulk cavities. Indeed the thin film technology is utilized in several accelerators, ALPI , which mounted superconducting Quarter Wave Resonators (QWRs), is an example. The 6GHz cavities are elliptical "scaled resonators" useful for optimizing the sputtering process for Niobium on Copper accelerating cavities. Indeed, this can be easily rescaled for being applied with the real accelerating cavities. The Niobium thin film sputtering on 6GHz cavities was performed in order to correlate the sputtering parameters with the superconducting radio frequency (RF) performance. In particular the sputtering process was performed at room temperature and at high temperature of the substrate; it is expected that the high temperature coating lead to a better crystallographic properties implying lower surface resistance and high Q-factor values [1].


The Llanbeblig Hours contains a number of miniatures, including a very rare 'Lily Crucifixion' motif. The motif juxtaposes the Crucified Christ against the lily plant, the lily becoming a consistent feature of Annunciation iconography from the thirteenth century onward. The Crucifix is not always included in Lily Crucifixions and in some examples Christ is shown nailed directly to the lily. The Lily Crucifixion, which appears in several other Annunciation scenes in other media, seems confined to the period between the fourteenth and sixteenth centuries. This paper discusses the Lily Crucifixion in the context of other examples of the motif in devotional iconography.

Other known examples: a carved alabaster panel or 'table', housed in a painted wooden case, last known in the Kunstgerwerbe Museum, Cologne (1375); a panel-painting on the the ceiling of St Helen's, Abingdon (c.1390s); an oil on oak panel-painting, c. 1470-1490 from Great Barton, Bury St Edmunds, now in the Victoria & Albert Museum (W.50-1921); a panel-painting on the screen of Kenn Church, near Exeter; A wood-carving (misericord) in Tong Church, Shropshire (1410); a carved-stone tomb-panel (tomb of John de Tannesley, d. 1414), St Mary's Church, Nottingham; a carved tomb-panel (of William Earnley, d. 1545, but tomb c.1530), Ss Peter & Paul, West Wittering, Sussex; another carved tomb-panel (of Richard de Whitenhall, no date, but c. C15th) at South Kilworth Church, Leicestershire; a stained-glass window at York Minster, north choir aisle (c. 1415); a second stained-glass window, the Church of St Michael-at-the- North-Gate, Oxford (C15th ); a third stained-glass window at St Mary's Church, Westwood, Wiltshire (c.1475); a fourth stained-glass window at The Great Church of the Holy Trinity, Long Melford, Suffolk (C15th)a fifth stained-glass window in the Chapel of Queen's College, Oxford (1500).


The methodology of teaching foreign languages is constantly looking for ways to effectively master foreign languages by primary school students. The article deals with the possibility of using digital and multimedia technologies in the process of forming foreign language grammar competence of younger students on the example of the German language. The analysis of foreign experience proved the relevance of the introduction of such technologies in the teaching process of educational institutions of all levels, but it also noted the lack of studying the method of using digital and multimedia tools in the process of forming foreign language competence of primary school students, in particular when learning grammar in German. It is considered that in modern educational development conditions it is important to take into account the features of modern students, who are digital native, and the use of digital and multimedia technologies in German lessons is a natural and understandable tool for them. Future teachers and those, who are practicing the early language teaching, need to overcome psychological barriers and doubts about the effectiveness of new tools to make digital and multimedia technology a daily practice. The article proposes digital and multimedia resources and programs that can be used in the process of forming a foreign grammar competence at different stages of grammar processing, while fully complying with the requirements of the program "Foreign Languages for General and Specialty Educational Institutions 1-4 classes" of Ukraine. The comparative analysis of online resources intended for the study of foreign languages, including German, with the existing foreign language program for the New Ukrainian School (2018), taking into account the level of foreign language communication competence at the time of graduation from 4th grade, allowed to systematize existing digital networks on the Internet and cartoon resources in accordance with vocabulary stock and vocabulary topics, which will help to apply them effectively in German lessons, to increase the motivation of younger students, to encourage an independent study of a foreign language


Combined with all sorts of factors which affected the safety in the process of electric engine serving operation,according to the demand of serving operation safety,the safety monitor and control system of servicing operation were empoldered using mechanism interlock,computer and data acquisition technology,as the traditional operation method of the insulation switch in electric engine serving track had unsafe factors.The System monitored the whole course of the insulation switch operation,the wire grounding and ascending the engine coping,inducted the operation with sound hint and shows the status of the process with chart.The programing implementation of the PCI_1756 in the Security Monitor and Control System of servicing processing was elaborated.


Thirty day old rice seedlings, Ilpoom and Taeback variety, grown under deficient condition of several elements in nutrition solution of sand culture were exposed to 20Gy, 40Gy, 80Gy of gamma ray to study the effect of their radiosensitivity. The results obtained are summarized as follows : Plant height and fresh weight of nutrient deficient rice plants were far less than those of control. The effect was different with nutrient element and rice variety, as show increasing effect of radiosensitivity in the Ilpoom variety was high in the Fe deficient whereas that of Taeback was high in the P deficient. Growth inhibition of rice plant irradiated with 20Gy was highly occurred in the Fe and Zn deficient plot in Ilpoom variety and P and Zn deficient plot in Taeback variety. In 80Gy irradiated group, radiosensitivity of rice plant was high in the P and Ca deficient plot of both Ilpoom and Taeback variety.


Anatomy and physiology of the endocrine and reproductive systems case histories and questions on the nursing care of - diabetes mellitus, hypothyroidism, carcinoma of the cervix (including hysterectomy), subfertility, pregnancy and labour, mother and baby (post-natal care), benign prostatic hypertrophy.


Image sensor according to the present invention, a substrate; Includes at least one insulating layer, each of the pixels constituting the image sensor formed on the substrate is formed in the substrate, the photodiode region to perform the photoelectric conversion and the; And a first lens that is formed on the insulating layer, converging the incident light; It is embedded in the insulating layer to be disposed between the photodiode region and the first lens, a second lens for converging the incident light. An image sensor, a lens, a photodiode, a color filter


Introduction My interest in the life and works of Edmund Stone (1695?-1768) began while conducting a study of Thomas Simpson's (1710-1761) works on fluxions, namely A New Treatise of Fluxions (1737) and The Doctrine and Application of Fluxions (1750) (Blanco, 2014). To understand the differences between both works, it was necessary to trace the mathematical influence of other authors on Simpson. Among these, I examined Stone's Method of Fluxions both Direct and Inverse (1730). Allegedly, this was the first book on fluxions that Simpson read. The "direct" part was a translation of the Analyse des infiniment petits (L'Hospital, 1696), while the "inverse" part was largely based on Cotes's Harmonia Mensurarum (1722). But, in addition to his Method of Fluxions, Stone published a large amount of mathematical works. Being the self-educated son of a duke's gardener, Stone's mathematical contributions were unusual, to say the least. One of his earliest works soon caught my attention, The Construction and Principal Uses of Mathematical Instruments, published in 1723. It was one of the earliest general manuals on mathematical instruments in English, if not the first. It was essentially a translation from the French version of Nicolas Bion's Traité de la construction et des principaux usages des instrumens de mathématique, first published in 1709. However, this book was not just a bare translation. As the title of the book indicated, Stone annexed a number of instruments that had been omitted by Bion, in particular, those that


narratives of people recovering from heart surgery, with reference to Arthur Frank's work on illness narratives. As an example in this presentation, we use data from a pilot narrative inquiry exploring patients' experiences of heart surgery and recovery. ''Restitution'' narratives (such as experiencing angina, having a myocardial infarction, receiving heart surgery and recovering) are the dominant theme in these stories of illness. The progressive advancements of cardiovascular science undergirds restitution narratives post-heart surgery, which relate experiences of noticing symptoms, obtaining a diagnosis, receiving treatment and being restored to various degrees of health. A review of the related literature and this pilot study reveal patterns of biographical restructuring and diverse illness experiences throughout the pathways of diagnosis and treatment. These data enable exploration of the elements of restitution narratives as the framework of the stories people tell of their heart surgery experiences. Methods: This pilot study is situated within the traditions of qualitative research. Qualitative methods seek to explore the richness and complexity of human experience, particularly when there is little knowledge about the phenomenon. A narrative approach is employed. Storytelling is part of our everyday lives and is the closest way to understand peoples' experiences. Semi-structured interviews are conducted with four participants who underwent heart surgery. Results: Although patients' stories of heart surgery and recovery are diverse, there is a common theme embedded within their narratives. The restitution narrative of recovering from heart surgery prevails in their stories, despite the opportunity to refer to other themes identified by Frank such as stories of chaos and finding meaning. Conclusions: This presentation provides an analysis of the personal needs and meanings that may underlie the prominence of this type of narrative in heart surgery. There is a certain amount of pressure to get well and narrate a story that represents this pathway. Stories that deviate from the restitution narrative may be seen as medical and personal failures. It is important to uncover the moral aspects that ensue from this type of narrative and the role of dialogue. Issues of moralization and dialogue in our technological culture of heart surgery demand our attention. This pilot study reveals that the technological is implicit in patients' stories of heart surgery. The ubiquitous nature of the technological in heart surgery is a strangely unexplored phenomenon and is the focus of further study.


Software release problems based on Jelinski-Moranda and decreasing-failure-rate models are considered. The following software release policy is considered: after a preassigned number, n, of errors are removed, the test is terminated and the software system is released to the operational phase. The average gain is used as a criterion; there exists a unique optimal value of n. Numerical examples indicate that the software release policy based on the number of errors detected can be a good alternative to the existing policy. >


We systematically investigated the influence of locked nucleic acid (LNA), unlock nucleic acid (UNA), and 2'-O-methyl-RNA (2'-O-Me-RNA) residues on the thermal stability, structure folding topology, biological activity and enzymatic resistance of three sequence-related DNA G-quadruplexes. In order to better understand the mechanism of action of the studied modifications, a single-position substitution in the loops or G-tetrads was performed and their influence was analyzed for a total of twenty-seven modified G-quadruplex variants. The studies show that the influence of each modification on the physicochemical properties of G-quadruplexes is position-dependent, due to mutual interactions between G-tetrads, loops, and additional guanosine at 5' or 3' end. Nevertheless, the anticancer activity of the modified G-quadruplexes is determined by their structure, thus also by the local changes of chemical character of sugar moieties, what might influence the specific interactions with therapeutic targets. In general, UNA modifications are efficient modulators of the G-quadruplex thermodynamic stability, however they are poor tools to improve the anticancer properties. In contrast, LNA and 2'-O-Me-RNA modified G-quadruplexes demonstrated certain antiproliferative potential and might be used as molecular tools for designing novel G-quadruplex-based therapeutics.


Abstract Results of sodseeding experiments have indicated that, provided adequate attention is given to the lime and fertilizer requirements, lucerne and white and red clovers can be successfully established in Dohne sourveld by sodseeding in the autumn. The need for further research on weed encroachment, sodseeding equipment and management of veld reinforced with legumes, is indicated.


Intracellular calcium is one of the important signals that initiates the myogenic program. The calcium-activated phosphatase calcineurin is necessary for the nuclear import of the nuclear factor of activated T cell (NFAT) family members, which interact with zinc finger GATA transcription factors. Whereas GATA-6 plays a role in the maintenance of the differentiated phenotype in vascular smooth muscle cells (VSMCs), it is unknown whether the calcineurin pathway is associated with GATA-6 and plays a role in the differentiation of VSMCs. The smooth muscle–myosin heavy chain (Sm-MHC) gene is a downstream target of GATA-6, and provides a highly specific marker for differentiated VSMCs. Using immunoprecipitation Western blotting, we showed that NFATc1 interacted with GATA-6. Consistent with this, NFATc1 further potentiated GATA-6–activated Sm-MHC transcription. Induction of VSMCs to the quiescent phenotype caused nuclear translocation of NFATc1. In differentiated VSMCs, blockage of calcineurin down-regulated the amount of GATA-6-DNA binding as well as the expression of Sm-MHC and its transcriptional activity. These findings demonstrate that the calcineurin pathway is associated with GATA-6 and is required for the maintenance of the differentiated phenotype in VSMCs.


The use of information technology and management has become a critical part of the drug discovery process. The rational design of new drug molecules involves input from various branches of science. In this context the information and management of bio and chemical information have become the integral part. In addition, it is of utmost importance to enrich potential libraries with those molecules which could be converted to suitable drug candidates or omited as toxins. During the practice of chemoinformatics, it has been realized that molecular diversity is an essential feature to characterize the reactivity of the molecules. In addition, a paradigm shift in structureactivity relationship has resulted in the integration of various descriptors and quantum chemical descriptors based drug development activities into early stages of lead discovery. In particular, various descriptors are being developed and used to help identify and screen out compounds that are unlikely to become drugs/toxins. This paper highlights the development of recent DFT based chemical reactivity descriptors and the application of these descriptors towards the prediction of chemical reactivity, especially in the prediction of toxicity and biological activities of nitroaromatic compounds. I.INTRODUCTION The data base development, management and analysis of biological information are defined as bioinformatics which includes various database management tools, analysis tools and molecular modeling. The term "chemoinformatics" has been introduced in the Annual Reports of Medicinal Chemistry in 1998 by Brown. Chemoinformatics is the amalgamation of those chemical information resources to transform data into vital information and chemical information into knowledge for the intended purpose of making better decisions faster in the area of drug lead identification and organization. In fact, both bioinformatics and chemoinformatics are generic terms that encompass the design, creation, organization, management, retrieval, analysis, dissemination, visualization and use of chemical and biological information. Chemi-informatics, chemometrics, computational chemistry, chemical informatics, and chemical information management/science are some of the related areas of chemoinformatics. The development of future chemical informatics systems will require a workforce with a solid grounding in chemistry and an expert understanding of the available computer technology. Chemical, agrochemical, pharmaceutical, and biotechnology branches of science require extensive input from both bioinformatics and chemoinformatics. The quantitative structureactivity relationship (QSAR) and the quantitative structureproperty relationship (QSPR) are the important tools of the bio-chemo-informatics which can be built essentially based on the data generated from the molecular modeling and computational chemistry. The QSAR and QSPR attempt to find a mathematical relationship between chemical structure and biological activity or chemical property for a series of homologous compounds. These series of homologous compounds are called the training set. The generated mathematical equation can be used to predict the activity or property of any new compound, which has been built from the chosen training set. Numerous descriptors have been used to develop QSAR and QSPR for different applications. In this regard it is necessary to mention the noteworthy contribution made by Hansch and coworkers to the development and growth of this area of activity. Nitroaromatic compounds are important materials or intermediates of explosives, pesticides, organic synthesis, and dyestuffs etc. With the development of industry, thousands of these compounds have being introduced into the environment every year and QSAR analysis on the toxicity of these compounds can provide us with valuable information. Hence, in the present investigation experimental toxicity values of 18 nitroaromatics to the algae (Scenedesmus obliguus) have been probed with DFT based descriptors. The DFT offers a strong foundation for various qualitative concepts in the chemical reactivity. 7 Popular qualitative chemical concepts such as electronegativity and hardness have been widely used in understanding various aspects of chemical reactivity. Recently, Geerlings and co workers have reviewed the tremendous development in the application of conceptual density functional theory to variety of chemical and biological problems. Although conceptual density functional theory has been used in numerous investigations to probe the chemical reactivity and site selectivity, their applications in the area of structureactivity relationship aspects of biochemoinformatics are limited. Some of the important contributions in this area are highlighted in the following section. Based on the success of these DFT descriptors as revealed in the previous studies 8, 9 and also due to their simple calculation procedure, the usefulness of the DFT descriptors in the QSAR parlance has been probed in detail.


We present a fast, low-cost technique to gather high-contrast 'relightable' photographs of desktop-sized objects. Instead of an elaborate light stage, we follow Mohan et al.; we place the object and a digitally steered spotlight inside a white cardboard box, aim the spotlight at the box interior, and move the spot to light the object from N repeatable lighting directions. However, strong ambient lighting from box interreflections causes 'shallow' shadows and reduces contrasts in all basis images. We show how to remove this ambient lighting computationally from the N images, by measuring an N ×N matrix of coupling factors between lighting directions using a mirrorsphere light probe. This linear method, suitable for any light stage, creates physically accurate 'deep shadow' basis images, yet imposes only a modest noise penalty, and does not require external light metering or illumination angle measurements. Results from our demonstration system support these claims.


I t is common to talk about options, where an option is a course of action an agent can take. A course of action, in turn, is that which can be the object of intention. For example, the infinitives in the following three cases pick out courses of action: I intend to have a beer; I intend to get a job at the mill; I intend to join the union. Talk of options occurs in the context of discussions of agency, judgments about what rationality requires, assessments of what we have most reason to do, accounts of what morality requires, and so it is found throughout philosophy of action, theories of practical reason, moral theories, etc. It has not often been noticed in this literature (in fact, as far as I can tell it has never been noticed) that there are two ways to understand what makes something an option: first, an option just is some course of action physically open (or, to be maximally liberal, logically open) to an agent; second, an option just is some course of action that the agent either in fact deliberates about taking or is psychologically capable of deliberating about taking.1 Let us, for the moment, dub the first kind of option an external option and the second kind of option an internal option. At any given time, there are far more external options open to an agent than the agent is psychologically capable of deliberating about taking or actually does deliberate about taking. Even if we fixed an otherwise normal agent's ends and fixed his attitudes towards his ends such that the ends stood in transitive preference relations to one another, and even if that agent was a maximally consistent and coherent practical reasoner, there would still remain many more means to achieving all the agent's ends than the (otherwise normal) agent in


Real-valued negative selection (RVNS) is an immune-inspired technique for anomaly detec- tion problems. It has been claimed that this technique is a competitive approach, comparable to statistical anomaly detection approaches such as one-class Sup- port Vector Machine. Moreover, it has been claimed that the complementary approach to RVNS, termed real-valued positive selection, is not a realistic solu- tion. We investigate these claims and show that these claims can not be sufficiently supported.


Summary Guinea pigs exposed to 1.5%, 3% and 15% CO2 for prolonged periods developed, under 3% and 15% CO2, hyaline membranes associated with atelectases which were predominantly located in subpleural areas. Simultaneous blood pH and pCO2 measurements indicated that these pulmonary lesions were related to a nonspecific acidosis effect rather than to a specific CO2 effect. Incidence of hyaline membranes declined from 100% during the uncompensated phase of respiratory acidosis induced by 1-2 days of exposure to 15% CO2 to 0% during 14-93 days of exposure to 15% CO2. Under the latter condition blood pH was compensated but blood pCO2 was elevated to a level twice normal. Rats did not exhibit hyaline membranes during prolonged exposure to 1.5% CO2 and 3% CO2.


Cutaneous metastasis is a condition where cancers originating from various parts of the body spread to the skin. There are rare but not unusual. The objective of our study is to study the epidemiological, clinical and evolutionary profiles of cutaneous metastases. Throw this retrospective study rendered over 6 years period from 2011 to 2016. 10 patients were selected from the dermatology department of Moulay Ismail's Hospital in Meknes. We deduced the following: The sexratio M/F is 2.3, the average age is 60.9 years. Skin metastases appeared mostly during the evolution of the primary tumor. The preferred seat of the MCs in study was the trunk. The clinical appearance was mostly nodular. Adenocarcinoma (60%) was the most frequent histological form followed by squamous cell carcinoma (40%). Evolution was unfavorable, as 40% of the 60% of patients followed died at about 3 months after diagnosis of MCs. Skin metastases are a sign of poor prognosis, and occur most often at a late stage during the development of tumor pathology, but on the other hand, MCs may reveal underlying neoplasia. Its asymptomatic character makes early screening difficult.


Objective To investigate the value of MRI diffusion-tensor imaging(DTI) in the diagnosis of motor neuron disorders by studying their characteristics in the cervical spinal cord DTI.Methods Conventional MRI and axial DTI of cervical spinal cord were performed in 16 patients with amyotrophic lateral sclerosis(ALS),12 patients with Kennedy disease(KD) and 15 healthy controls.FA and ADC values were measured in regions of interest(ROI) selected in anterior funiculus,posterior funiculus,and bilaterallateral corticospinal tracts,respectively,at the same slices(C3 and C5).In the patients with motor neuron disorders,the relations between DTI parameters and their age,duration,score of ALSFRS-R and FVC% were analyzed.Results The FA values in the anterior funiculus and bilateral lateral corticospinal tract in ALS patients were significantly lower compared with those in the KD group and the healthy control group on both C3 and C5 levels(P0.05).The FA values between KD group and control group were comparable(P0.05).No significant differences in ADC values were present among the three groups in all different locations(P0.05).On C3 level,the FA values in the right corticospinal tract in ALS patients were positively correlated with ALSFRS-R scores(r=0.52,P=0.041);but the FA and ADC values in the anterior funiculus and bilateral lateral corticospinal tract had no correlation with the patients' duration and FVC%.Conclusions FA value reflects functional abnormality of cervical corticospinal tracts.DTI can be used for objective evaluation of upper motor neuron impairment in amyotrophic lateral sclerosis and contributes to the differential diagnosis in motor neuron disorders.


Microgrids are decentralized power production systems, where the energy production and consumption are very close to each other. Microgrids generally exploit renewable energy sources, encountering a problem of storage, as the power production from solar and wind is intermittent. This research presents a new integrated methodology and discusses a comparison of batteries and pumped storage hydropower (PSH) as energy storage systems with the integration of wind and solar PV energy sources, which are the major upcoming technologies in the renewable energy sector. We implemented the simulator and optimizer model (HOMER), which develops energy availability usage to obtain optimized renewable energy integration in the microgrid, showing its economic added value. Two scenarios are run with this model—one considers batteries as an energy storage technology and the other considers PSH—in order to obtain the best economic and technical results for the analyzed microgrid. The economic analysis showed a lower net present cost (NPC) and levelized cost of energy (LCOE) for the microgrid with PSH. The results showed that the microgrid with the storage of PSH was economical, with an NPC of 45.8 M€ and an LCOE of 0.379 €/kWh, in comparison with the scenario with batteries, which had an NPC of 95.2 M€ and an LCOE of 0.786 €/kWh. The role of storage was understood by differentiating the data into different seasons, using a Python model. Furthermore, a sensitivity analysis was conducted by varying the capital cost multiplier of solar PV and wind turbines to obtain the best optimal economic solutions.


Organic matters and waste products are used as nitrogen fertilizer in the urban and periplant production in Kinshasa city, Democratic Republic of Congo. Jatropha curcas L. (JCL) seed cake was mixed thoroughly with CREN-K soil(96%sand) and incubated for 1, 3, 7, 14, 21 and 42 days in glass flask under controlled conditions (28°C and 20% of moisture content). At the end of each incubation period, mineral nitrogen was extracted by adding 1N KCl (ratio KCl: soil 1:2). NH4 -N content was higher than NO incubation periods and reached a maximum value of mg N/Kg of soil. Net inorganic N (NH4 -N+NO was relatively rapid during the first 14 incubation.Rich in nitrogen (5. 67%),JCL seed cake has a potential to be utilized for soil fertility improvement and can be used as bio-fertilizer for short vegetative cycle of market gardening's.


Physical activity declines among children in their tweens and teens. To address physical inactivity as a health risk, national organizations are endorsing the implementation of comprehensive school physical activity programs (CSPAPs). The purpose of this article is to describe the history of school-coordinated approaches to addressing health issues and to provide steps for implementing CSPAPs in middle-school settings. The current need, theoretical-based rationale, how-to steps, and strategies for overcoming barriers are included. The article also includes sample artifacts from effective middle school CSPAPs and identifies multiple resources for CSPAP implementation.


Abstract : The time linearized Euler method Lin3D is applied to two sets of test cases. 2D wave propagation test cases in homogeneous flow are used to quantify numerical dissipation and dispersion of the discretization scheme. The minimum number of mesh diagonals between two wave fronts has been found to be an appropriate measure of the resolution of a wave. Correlations have been found that characterize the dissipation and dispersion behavior of the code and therefore the resolution requirements for a given flow simulation. The transmission and reflection of plane sound waves incident upon a single cascade of finite plates has also been calculated with Lin3D and compared with an analytical method of Koch 5. The computed ratios of transmitted or reflected to incident pressure wave amplitude agree well with the analytical solution, even for scattered modes


This research has established the presence of a natriuretic peptide system in the cardiovascular system of the toad, Bufo marinus. The presence of atrial natriuretic peptide mRNA and the peptide itself were shown in the heart which does not contain natriuretic peptide receptors in contrast to the large arteries and veins. In arteries these receptors mediated vasodilation. Atrial natriuretic peptide released from the heart may act on large arteries to regulate blood flow, but the action does not target the heart.


The effectiveness of multicultural training among a sample of predominately Hispanic counseling students was examined. The results of a series of 2-factor repeated measures analysis of variance and follow-up paired-samples t tests suggest that multicultural training was effective in increasing students' multicultural competencies and in improving their cognitive racial attitudes. Students' affective racial attitudes were not changed. Students' perceptions of their multicultural training suggest that students from diverse racial/ethnic backgrounds may experience multicultural training differently and unique life experiences may help explain this difference. Counselor educators may wish to use a variety of training experiences to provide multicultural training that is effective across diverse student populations.


Institute of Korean Food Research and Development, National Academy of Agricultural Science, RDA, Gyeonggi 441-853, KoreaAbstractThis study was to analyze the physiology activity of barley leaf extract using different drying methods. Yield of RL (raw leaf) and barley leaves dried did not show significant difference by various drying methods. There was no significant difference in total phenolic content by dry method. However, total flavonoid content was high in HD (dried after heat treatments) barley leaf after RL. There was no significance in barley leaf dried by SD (dried in the shade), FD (vacuum freeze dried) and MW (dried by microwave) after the microwave. Superoxide dismutase-like activity was high over 90%: 95.6±0.3% in RL, 94.9±0.7% in HD barley leaf, 92.0±1.3% in SD barley leaf, 91.5±0.4% in FD barley leaf, and 92.5±0.2% in MW barley leaf using the microwave. Significantly higher antioxidant activity was shown as compared to the control group of sesamol (88.426±0.802%), tocopherol (88.8±0.6%), and BHT (86.6±0.8%). Also, except for RL and MW barley leaf, all showed over 80% peroxyl radical scavenging activity and over 90% inhibition rate of xanthine oxidase. The results of this study show that total phenolic content and total flavonoid content by dry method were dependent on the drying temperature with no impact on antioxidant activity.Key words: barley leaf, drying, flavonoid, SOD-like activity, xanthin oxidase, peroxyl radical


The purpose of this study is to explore the sensory processing difficulties of Grade R learners that are diagnosed with Asperger's Syndrome (AS) in two schools in South Africa. Attwood (2007, p. 271) considers sensory sensitivities to have a greater impact on the lives of these individuals, than problems with making friends, managing emotions and coping academically. This research approach was purely qualitative; it used interviews and observations. The sample consists of two independent case studies composed of learners aged between five and seven who had been clinically diagnosed with AS. The results confirmed sensory processing difficulties, and illustrated how these difficulties impacted on the general learning and development of learners diagnosed with AS. Although they were both bright learners, they were perceived as underachievers. By identifying these sensory difficulties and creating awareness among educators, it is possible to debunk misconceptions people have of the adaptability of these learners to a mainstream school environment.


The conjugate addition of alcohols to α,β-unsaturated alkynic acid esters proceeds under neutral conditions in the presence of a catalytic amount of trialkylphosphine to give the corresponding β-alkoxy-α,β-unsaturated alkenic acid esters in good to excellent yields.


It has become common in theological literature to emphasize the differences between the ancient world and the post-modern world. It is imperative to be aware of these differences in order to avoid serious mistakes in one's exegesis, and in the hermeneutical process.


We report temperature-dependent measurements of the terahertz (THz) vibrational spectrum of ammonium nitrate (AN) films and mixed potassium nitrate (KN)–ammonium nitrate films using waveguide THz time domain spectroscopy. The experiments were performed on polycrystalline films on the metal surface of a parallel plate waveguide. At cryogenic temperature and with frequency resolution as high as 7 GHz, our measurements produce a complex vibrational spectrum for AN, and show vibrational resonances not observed in previous far infrared and Raman measurements. We investigate potential interactions between AN and the metal surface by measuring THz spectra of films on aluminum, gold, and a gold surface coated with an organic self-assembled monolayer. Measurements are also performed on a deuterated AN film and indicate that the observed THz modes are due largely to the motion of the nitrate ions in the AN crystal. Finally, the effect of introducing small amounts of an impurity into the AN lattice is examined. We f...


accepted for poster presentation at SASOG 2008 2. R Gangaram, M. Naicker, J Moodley. Accuracy of the spot urinary microalbumin:creatinine ratio and visual dipsticks in hypertensive pregnant


The article considers the problem of the balance between the principle of legal certainty and effective protection of individual rights in court cases, where the trial ended with a final court decision, in light of declaring laws and other acts unconstitutional. The issue of validity of decisions of the Constitutional Court of Ukraine in time is therefore discussed in the article.
The authors emphasize Supreme Court statement that the possibility to review a court decision in exceptional circumstances (if it is not executed only) is based on the principle of legal certainty, and the unconstitutionality of the law is important, first of all, as a general decision. It determines the legal position for resolving the following cases, and not as a basis for retrospective application of the new legal position and thus change the state of legal certainty already established by the final court decision.
The article points out that declaring the law unconstitutional indicates a mistake on the part of the state and undermines confidence in the court decision. The public interest in eliminating doubts about the legality and validity of a court decision prevails over the public interest, which is manifested in compliance with the principle of legal certainty.
It is underlined that the duty of the state is to ensure human rights and freedoms within the framework of the right to judicial protection and fair trial. The purpose of extraordinary procedures for reviewing a court decision is to restore violated constitutional rights and freedoms. Legal provisions on the possibility of reviewing not executed court decisions only, limit the guaranteed right to judicial protection and makes it impossible to implement the decisions of the Constitutional Court of Ukraine.
Constitutional complaint is equated to a complaint against the state to the European Court of Human Rights (he ECtHR), as it concerns the application of an unconstitutional law by a court (state). Procedural Codes of Ukraine stipulate that if the ECtHR finds the violation of Ukraine's international obligations in resolving a case by a court, it is the ground for reviewing a court decision that has entered into force and is final. Therefore, the conclusion is made that the law is inconsecutive.
In the light of the principles of the rule of law and responsibility of the state before a person there is a need to change the legislative regulation on review of court decisions in connection with the constitutionality of a law, other legal act or their separate provision, applied (not applied) by the court in the case. It is offered to introduce the institute of circumstances of a substantial and compelling character that influenced the outcome of the case as the ground for reviewing a court decision in exceptional circumstances – declaring the act unconstitutional, to Ukrainian procedural codes.


According to the fundamental principle of using criminal law equally,the men's sex rights and the women's sex rights should be protected equally by the criminal law.In fact,our country's criminal law prefers women's sex rights rather than men's.Therefore,we should improve criminal protection of men's rights by legislation.


CONTENTS: WHAT ARE THEY & HOW DO THEY WORK BY DENNIS J. CURRAN (NATIONAL ASSOCIATION OF FOREIGN TRADE ZONES). -- WHY ARE THEY AND UNDER-USED RESOURCE BY R. CHRISTOPHER WYATT (PRICE WATERHOUSE)-


Extended spectrum β-Lactamases (ESBL) are enzymes produced by pathogens belonging to Enterobacteriaceae, most commonly Escherichia coli and Klebsiella pneumoniae (Kenneth et al., 2010). They cause serious infections and have high mortality rates. Multidrug-resistant ESBL E. coli (CTX-M enzyme type) has emerged as an important cause of UTI (Gisele et al., 2010). ESBL strains are capable of efficiently hydrolyzing many beta-lactam antibiotics International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 1 (2017) pp. 411-415 Journal homepage: http://www.ijcmas.com


This paper contributes to the literature on the new politics of social inclusion and spatial justice in globalizing cities. My main argument is that accounts of such politics should focus on the multiple intervening social actors without neglecting or assuming the roles played by the urban middle classes. Focusing on the case of the City of Buenos Aires (CBA) after Argentina's neoliberal crisis of 2001, I show the importance of mobilized middle-class social actors in shaping institutional and territorial outcomes in a globalizing city that is highly polarized and fragmented. This study is based on participant observation, in-depth interviews, and archival research focused on (a) subscribers of state-sponsored citizen participation processes and (b) neighborhood activists with middle-class profiles—middle incomes, relative housing stability, and residency in neighborhoods with middle levels of development. Findings show that, although middle-class politics in the city evidenced a primary concern with place, neighborhood, and local territories, mobilized actors were also responding to deeper transformations brought about by processes of neoliberal globalization. Their repertoires of collective action also moved beyond the local scale and had significance for the wider governing of the city. Finally, it is shown that middle-class politics in the postcrisis CBA departed from the exclusionary attitudes evidenced in studies of other cities, which leads to the question of how such politics may be reconciled into broader coalitions seeking more egalitarian forms of urban globalization. Further inquiries for comparative analysis beyond the CBA are suggested in the paper's conclusion.


XUN Zi argues that the "harmony" means that one should be in his proper position,perform his duty properly,do his best as he can do,and be awarded what he should be awarded,which is a fundamental law of the universe.To realize such a homony human society,the social rullers have to follow the law of universe,and then develop complete paprieties and rules that based on such a law."To determine one's social status according to his moral,and to determine one's office duty according to his ability,which ensures that all human beings perform their duties and be awaded what they should be awarded",and it ensures that the society be operated orderly.


We read with great interest the article by Bomman et al. regarding the transition to transoral incisionless fundoplication (TIF) in an outpatient setting. TIF is a minimally-invasive endoscopic fundoplication technique used for gastroesophageal reflux disease (GERD). It was first introduced in 2005, approved by the Food and Drug Administration in 2007, and is performed using an EsophyX device (EndoGastric Solutions Inc., Redmond, WA, USA). The procedure and the device to perform TIF have evolved over the years. TIF procedures currently in practice include TIF 2.0 and cTIF (concomitant TIF with hiatal hernial repair). TIF 2.0 is reserved for patients with hiatal hernial size of ≤2 cm or Hill grade ≤2; cTIF is performed in patients with hiatal hernial size >2 cm or Hill grade >2, similar to the surgical fundoplication performed in this patient population. The technique aims to create a full-thickness, 270° to 300° circumference esophagogastric fundoplication with the device, elongating the intra-abdominal esophagus by 2 to 4 cm. There is growing evidence of the safety and efficacy of this procedure. In a previous issue of Clinical Endoscopy, Bomman et al. reported their experience with 30 cases, where TIF (TIF 2.0) was adapted as a new procedure at a tertiary U.S. center in a stepwise approach from an inpatient operating room to a fully outpatient procedure. As the first step, three procedure sessions (nine cases) were performed in the operating room with overnight admission and esophagography. In the second step, TIF was transitioned to being performed in an endoscopy suite as a complete outpatient procedure with same-day discharge. The technical success rate of the procedure was 97%; no major adverse events were reported. There was no difference in the 30day readmission rates between the two groups (one case in each group). The procedure time decreased with more experience and as it transitioned from the operating room to the outpatient endoscopic suite. Only one technical failure occurred in a patient who had undergone prior sleeve gastrectomy. Performing full-thickness esophagogastric fundoplication using TIF after sleeve gastrectomy can be challenging. Even with a skilled endoscopist, this may not be technically feasible, given that the left fundus may not be adequate for TIF. Unfortunately, data on such cases are limited. An alternative option of performing TIF procedure before bariatric surgery is yet to be supported with evidence. Shah et al. successfully demonstrated a case of same-session TIF followed by endoscopic sleeve gastroplasty in 2020 in a patient with GERD and obesity. Bomman et al. demonstrated that TIF was technically successful in four patients with prior altered anatomy (hernia repair, hernial repair with partial fundoplication). In addition, TIF was successfully performed in This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


George Catlin, pioneer, author, ethnographer, entrepreneur, was foremost an artist of exceptional talents. He made five difficult journeys westward from 1830-1836 to paint the Native Americans and their way of life. His artistic work comprised the first pictorial record of western Native Peoples. In Catlin's view, a visit to the sacred Pipestone Quarry, located in southwestern Minnesota, would be a fitting finale to his documentation of Native American tribes of the West. Catlin felt it necessary to subject the quarry to his presence, to extract stone for study, and to preserve the quarry through his painting. Everywhere the artist had gone in his travels, from the Mississippi to the Rocky Mountains, and from the Canadian border into Mexican territory he had witnessed the smoking of the long-stemmed Indian pipe that was an important ritual in every phase of diplomacy, peace, and war. The quarry was the central site that over the millennia held hundreds of tribes in communication with each other. In Catlin's time, the quarry was guarded by the Santee Sioux, protecting their economic interest in this valuable substance, pipestone, as well as the sanctity of the resource from which they believed the Great Spirit had fashioned man. In Catlin's final pilgrimage to round out his western travels his goal was to view this sacred site.


The paper uses the concept of integration to examine the development of continuing professional education (CPE) in Australia, with special reference to policy and provision. Tour potential areas for integration are noted: with professional education; with other educational sectors; in terms of cross professional contact and research; with regard to the purpose of CPE. A brief historical scan of the development of CPE is followed by a discussion of two major policy issues: mandatory or voluntary participation, and competencies. From the discussion a framework for CPE policy and provision in a more integrated manner is proposed. Though the prospect of widespread integration is not envisaged, opportunities do exist for integrated CPE policy and provision in several areas discussed.


The problem of robust stabilization with definite attenuance for a class of linear uncertain time delay systems is considered in this paper. The systems under consideration include time varying unknown but bounded uncertain parameters and time delay in state. A criterion of robust stability with definite attenuance and the method of designing a state feedback controller guaranteeing the system robust stable with definite attenuance are derived. The results depend on the size of delay and are given in terms of linear matrix inequalities.


In contrast to traditional teaching methods of pharmaceutical analysis,this new innovative teaching method which introjects the scientific research thinking mode throughout the teaching can promote the students to comprehend the basic knowledge,and improve experimental skills,which plays a role in priming students awareness of innovation and the training of the innovation ability of students.


I was fortunate to have been able to attend last year's BACCN Conference, thanks to the encouragement and support of my intensive care unit (ICU) mentors, and agreed to share my impressions as a relative novice to ICU nursing. This was my first nursing conference, and I was struck by a number of things. York is a beautiful and historic city, and racecourse, with all its quiet grandeur and more than adequate conference facilities, was a superb choice of venue. The conference itself was very well organized and managed, with experienced and attentive staff. There was a seemingly endless array of exhibitions and stalls to inform and spark interest. The keynote speeches were relevant, inspiring and informative and, in the case of Peter Sharp and his 'serotonin moments', amusing as well as supportive in focussing on the need for self-care in order to be able to care. The food was good, and the conference dinner a triumph – a lovely meal in the atmospheric and memorable setting of York's National Railway Museum, the evening replete with music, dance, games and much laughter – definitely 'serotonin moments' in abundance! It was also lovely to meet up with former colleagues now working elsewhere and hearing about their new experiences and development. But what inspired and reinvigorated me most of all was just how caring, competent and collaborative nurses are and, once again, how proud I am to be a member of this profession, despite all the exhaustion and bureaucracy that threaten so often to drown out the excitement and joy of knowing that perhaps you have made a difference to someone's life, been instrumental in their recovery, reassured and supported family and friends well or provided a safe and dignified atmosphere when nothing more could be performed. At presentation and after presentation and each poster, it was clear to see that nurses care enough to want to identify concerns or problems and find ways of changing things for the better, always with the aim of providing enhanced nursing care. Just hearing them present evidence of their efforts to improve service or serve in challenging circumstances, such as a field hospital in Afghanistan, speaks to nurse's competence and professionalism, not to mention bravery every day wherever they work. And I will dare to say that across the entire medical system, nurses are already supreme collaborators, both because we have to be in order to provide and orchestrate holistic care to our patients and becausewe are the glue that holds the system together. Yes, there is always room for development and growth, but we collaborate constantly and, most often, very well. Whether our 'shop floor' collaborations and communications are always invited or heard is another matter and therein lays scope for development and collaborating with each other through conferences such as this in order to encourage and inspire each other's confidence. And it is all these things (and more, of course) that have to conspire to improve patient safety overall and identify deteriorating patients in particular: caring enough to notice, the competence to act quickly and decisively and the skills to collaborate effectively with whoever is necessary to inform and enhance the care in which we collaborate. It was not just in politeness that Mandy Odell was strongly applauded across the board when she suggested that nurses best serve patients when they are actually free to be at (or at least near) the bedside. As a novice ICU nurse, I cannot emphasize enough how important it is that more experienced and confident colleagues are near the bedside as much as possible, especially when the indecisiveness and sheer terror (at times) of inexperience can have a paralysing effect. Attending the conference has been informative and thought provoking, yes; but equally, it has been a humbling and inspiring experience, which has reinvigorated and refocused. For all this, I am grateful.


The recent article by Ebright et al.1 called attention to the unintended consequences of autoantibody testing using the Mayo paraneoplastic panel. Their work presented a compelling demonstration of Bayes theorem,2 which describes the probability of an event given knowledge of a related event:


Knowing the survival of Escherichia coli (E. coli) is important in evaluating the fecal contamination level in dredged marine soils. The significant factors in the survival of E. coli in dredged marine soils are important to know because marine soils can act as reservoir for bacteria. The soils physico-chemical properties are likely to affect the survival of bacteria. In fact, the relationship between soil characteristic such as type of soil, particle sizes, pH, moisture content and organic matter were related with the pattern of bacteria concentration. A study was conducted on the physico-chemical properties of marine soils samples dredged from two different dredging sites in Peninsular Malaysia. The results of the present study show that physico-chemical properties of the dredged marine soil measured varied among two dredging sites. The soils with finer fraction, high in pH, moisture content and organic matter appear to have high concentration of bacteria.


A high level of genetic purity in crop plants should be maintained for good agronomic performance to encourage the innovations in plant breeding strategies. It ensures the improvements in productivity and subsequently delivered to farmer. Traditionally, morphological comparisons of seeds and grown plants have formed the basis for genetic purity evaluations and certification. Morphology cannot provide information on the purity of specific genetic attributes that relate to grain quality or to pest or herbicide resistance bred into varieties so newer DNA-based biotechnological tools are required for seed purity assessment in crop plants.


With wireless communications and geo-positioning being widely available, it becomes possible to offer new e-services that provide mobile users with information about other mobile objects. This paper concerns active, ordered k-nearest neighbor queries for query and data objects that are moving in road networks. Such queries may be of use in many services.Specifically, we present an easily implementable data model that serves well as a foundation for such queries. We also present the design of a prototype system that implements the queries based on the data model. The algorithm used for the nearest neighbor search in the prototype is presented in detail. In addition, the paper reports on results from experiments with the prototype system.


12047 Background: Metastatic colorectal cancer (mCRC) is a leading cause of death, particularly in older adults. Regorafenib (REGO) is an FDA-approved oral multi-kinase inhibitor for refractory mCRC based on the CORRECT trial results, but older adults were underrepresented with a median age of 61 (54–67). This study aimed to evaluate REGO safety in older adults with mCRC and assess the feasibility of using geriatric assessment (GA) to predict toxicity risk. Methods: 27 subjects (PTs) enrolled (median age 73, range 65-85) and started at 120mg of REGO for 21 days of a 28-day cycle with provider discretion to escalate to full dose of 160mg after cycle 1. GA was conducted at enrollment, 4 weeks later, and then every 3 months to monitor for any deterioration. GA assessed 8 geriatric domains (comorbidity, functional status, physical performance, cognition, psychological state, nutrition, medication review, and social support) using validated tools. Primary objective was to assess grade 3-5 toxicity rate, with secondary objectives evaluating REGO efficacy and exploring baseline GA and toxicity risk associations. Kaplan-Meier method was used to estimate median overall survival (OS) and progression-free survival (PFS) from date of consent. Continuous GA measures were compared using non-parametric Wilcoxon rank-sum test, and binary GA measures were compared using Fisher's exact test. Results: Of 27 PTs enrolled, 15 were male, 12 were female, and 19 identified as white. At baseline, 77.7% of PTs had at least 3 (1-9) GA impairments. Physical performance (80.8%), comorbidity (75%), and cognition (69.2%) were the most prevalent impaired GA domains. 40% required dose reduction by end of cycle 2, and none escalated to full dose. 55% of PTs completed cycle 3. Main reasons for drug discontinuation were disease progression (80%) and toxicity (12%). 74.1% of PTs experienced at least one treatment-related grade 3-4 toxicity. Fatigue (33%), hypertension (30%), and hand-foot syndrome (15%) were the leading grade 3-4 toxicities. Median OS was 5.6 months (95% CI: 3.6-12.2m), and median PFS was 2.8 months (95% CI: 2.5-3.4m). There was no significant difference in baseline GA measures between those who experienced toxicities and those who did not. No statistically significant toxicity risk was associated with any baseline GA impairment. The prevalence of impaired mini-nutritional assessment increased over 4 weeks (58% to 91%, p < 0.01), and median Short Physical Performance Battery (SPPB) scores decreased (7 to 6, p = 0.03). Conclusions: The study found that older adults with mCRC had comparable survival with REGO but experienced high toxicity. This may be ameliorated by recently published step-wise REDOS dosing method and should be considered in older adults with mCRC. The study confirms the feasibility of implementing GA within clinical trials. More data is needed on the role of GA in predicting toxicity with targeted therapies. Clinical trial information: NCT02466009 .


The magnetic field produced in a plane conductor by a non-relativistic line charge moving parallel to the face is examined on the basis of classical electromagnetic theory. It is discovered that, at a fixed speed less than the local speed of light, skin effect is not a significant feature and the magnetic intensity decays algebraically rather than exponentially with distance from the face of the conductor. The multiplying factor does, however, depend upon the conductivity and becomes zero for a perfect conductor. For Cerenkov radiation, on the other hand, the position is reversed; skin effect is dominant and the attenuation is exponential. This result may affect the interpretation of the Aharonov-Bohm effect which is currently under discussion.


Aiming at the application requirements of three-dimensional (3-D) fusion imaging of network radar, this study proposes an ISAR imaging resource-scheduling algorithm for network radar. Based on the feature recognition of each radar to each target, a projection-based method is first used to fuse the 3-D information of targets. Then according to the fused information, the demand of time resources for each radar is analysed. The radars selected for each target imaging are determined. Finally, the scheduling model of the imaging task for network radar is established, and time resources for each radar are randomly allocated. The simulation results show that the scheduling success rate of the proposed algorithm is two times on average than that of the traditional algorithm under the situation when the resources are near-saturated for both algorithms, which can improve the efficiency of network radar.


This report is a collection of studies performed at Sandia National Laboratories in support of Phase One (inert debris) for the Risk and Lethality Commonality Team. This team was created by the Range Safety Group of the Range Commander`s Council to evaluate the safety issues for debris generated during flight tests and to develop debris safety criteria that can be adopted by the national ranges. Physiological data on the effects of debris impacts on people are presented. Log-normal curves are developed to relate the impact kinetic energy of fragments to the probability of fatality for people exposed in standing, sitting, or prone positions. Debris hazards to aircraft resulting from engine ingestion or penetration of a structure or windshield are discussed. The smallest mass fragments of aluminum, steel, and tungsten that may be hazardous to current aircraft are defined. Fragment penetration of the deck of a small ship or a pleasure craft is also considered. The smallest mass fragments of aluminum, steel, or tungsten that can penetrate decks are calculated.


A new technique for compression of binary images is proposed. The Radon transform is used to convert a binary image to a set of 1-dimensional (1-D) non-binary sequences, which are coded using 1-D techniques. A binary image can be reconstructed from a very small number of projections and this leads to significant compression. The compression ratio for a binary image of size NxN is inversely proportional to N.


ABSTRACTThe model of student effort choice implicit in the literature is a tradeoff between the utility of scoring well on examinations and the disutility of the effort expended studying. The existing literature contains only minimally specified model structures. This paper develops the implicit model in the literature with an explicit utility maximization problem. The solution to the student's choice of effort is then empirically estimated with a unique and much broader data set. The results provide a more complete perspective on the factors determining student choice of effort. The model is then extended with estimation of a production function allowing for a calculation of the marginal effects that each of the variables ultimately has on score through its impact on effort.(JEL CODE: A22, D24, 121)Keywords: Education Production Functions, Student Effort(ProQuest: ... denotes formulae omitted.)INTRODUCTION AND LITERATURE REVIEWStudent effort is recognized as an important input in education production function. Although effort is essential in the theoretical modeling of education production, the direct treatment of effort has been limited both theoretically and empirically. Student effort has been modeled in the literature by McKenzie and Staaf [1974], Wetzel [1977], Becker [1982], Becker and Rosen [1992] and Krohn and O'Connor [2005] . A limitation found in these previous studies are they are focused principally on modeling educational production and give effort limited attention and tend not to empirically estimate effort at all.Empirical estimations are limited to studies by Wetzel [1977] and Krohn and O'Connor [2005]. These empirical studies offer limited explanations of the connection of the regressors to the utility function of the student or to the educational production function. Wetzel [1977] estimates regressions where the dependent variables are indirect measures of effort. Wetzel constructs three McKenzie and Staaf [1974] styled effort variables by dividing gain in TUCE scores by three different aptitude scores based on the SAT as a proxy for effort. Wetzel uses end of semester TUCE score and never directly observes student effort. In the Wetzel study, explanatory variables are limited to student grade expectation and hours worked as predictors of student effort. Wetzel finds student work hours has a negative impact on effort and grade expectation has a positive impact on effort. More recently, Krohn and O'Connor [2005] estimate student effort with an actual observation of effort rather than a McKenzie-Staaf proxy. However, the independent variables used to estimate effort are limited to a small vector of human capital measures, GPA, SAT and previous classes in economics. Other regressors include the pretest score and a dummy variable for gender. Krohn and O'Connor find students with higher ability study more. They also find evidence that females may in fact put forth more effort and that higher exam scores earlier in the semester lead to less effort exerted later in the semester. Overall, the collective right hand specification in this literature is thin and the development of this topic has been limited.The purpose of this paper is to add to the existing literature by developing a more thorough specification of the model structure and provide an explicit connection of the empirical estimation of effort to the underlying student utility function. The resulting model provides a more complete perspective on the vectors determining student choice of effort. The empirical model will then be estimated using a richer list of explanatory variables than has previously appeared in the literature. The results will be used to calculate both marginal effects on post test scoring and the actual learning differentials implicitly observed in our data. This approach provides a fuller presentation of the determinants of effort in both theoretical utility maximization and the observed impact of effort determinants on learning. …


The idiosyncratic volatility is a key input to the standard event-study method. The recent literature has suggested that the idiosyncratic volatility is not stable through time. This paper investigates the extent to which the event-study method is affected by this economic phenomenon. Using both simulation and real dataset analyses, we show that standard event-study methods suffer from a significant loss of power in the presence of increasing idiosyncratic volatility, as intuition would suggest. This affects the comparability of event study results obtained in two different empirical contexts (time periods or geographical zones). Therefore, to compare results between high and low regime of idiosyncratic volatility on a fair ground, everything else being equal, the ratio of the sample sizes needs to be equal to the ratio of the idiosyncratic variances in the two contexts.


Purpose of study: Vascular injuries caused by high-velocity military missiles are associated with bone fracture, soft-tissue, nerve and tendon injuries. In this study we will discuss the surgical strategy and results of vascular injuries, which require a different approach from primary and elective surgical procedure. Basic methods: Surgical interventions were performed in 1 16 patients. Vascular lesions were localized on the lower extremity in 53, upper extremity in SS. and nine were in other regions. Vascular injuries were concomitant with bone fracture in 46 and nerve iqjuries in 36 patients. Vascular repair was performed after orthopedic stabilization in vessels with an ischemic period of less than 4 hours. Principal findings: Fasciotomy was performed after vascular repair in the 22 cases that had arrived after 8 hours. Amputation was required in two cases. There was one mortality. C O ~ C ~ U S ~ O ~ S : The best results are obtained when a multidisciplinary and emergency approach are used by the team of vascular, orthopedic, plastic and neurosurgeons who are experienced in military i@uries. O 1998 The International Society for Cardiovascular Surgery. Published by Elsevier Science Ltd. All rights reserved


For the design of devices using the quantum effect, it is necessary to know the wavefunction of the electrons and holes in the quantum well and multiple barrier structures as well as the characteristic energy levels and resonance levels. It is necessary further to manipulate the potential structures to synthesize a desired phenomenon. to attain these objectives, applications of circuit theory to the analysis and design of quantum effect phenomena have been attempted.

In this paper, it is shown that the 2 × 2 interface matrix representing the continuity of the wavefunction and the boundary condition on the wavefunction accompanied by the T-X mixing are expressed in terms of the lossless two port and four port, respectively. By means of this procedure, it is now possible to carry out a circuit-oriented treatment of the behaviors of the electrons and holes in the case of superlattices other than GaAs systems requiring the interface matrix and the case where mixing between the minimum points of the conduction band in GaAs/AlxGal - xAs for which no circuit treatment was previously possible. They can now be analyzed systematically with the circuit functions and circuit matrices of the equivalent circuit without special boundary conditions. Also, by means of the proposed circuit representation, analysis examples are presented for the tunneling phenomena in these potential structures.


As one of the basic industries in the manufacturing industry, the modeling and evaluation of resource utilization efficiency in the machining process is the premise of energy conservation and consumption reduction in the manufacturing industry. Mechanical processing is the process of using resources to change the shape and performance of the blank to form the workpiece and generate emissions. However, the current research on the utilization of machining process resources, whether focusing on energy efficiency or emissions, cannot provide a comprehensive solution to this problem. Therefore, this paper proposes a Data Envelopment Analysis (DEA) model with a slacks-based measure (SBM) to evaluate the resource utilization efficiency of a machining process with non-expected output. Through the relative effectiveness of DEA, the resource utilization efficiency of each processing process can be compared, which can provide a feasible and specific method for enterprises to evaluate their existing processing processes from the perspective of reducing unexpected output. In this case, the input-output model of the machining process is used to analyze the processed resource list. Then the mathematical model of each process in the processing process is established, and the dynamic resources are determined quantitatively. Finally, the accuracy of the method is verified by combining the resource utilization efficiency of each working procedure in the shaft gear machining process of an enterprise.


The present study evaluated the impact of sea background noise (the acoustic environment of the offshore aquaculture system) and onshore aquaculture system's ambient noise on welfare of gilthead sea bream juveniles (Sparus aurata). In particular primary, secondary (biochemical and haematological indexes) and tertiary (growth performances) stress responses were evaluated. The experiment lasted 120 days during which two different playlists of acoustic stimuli were projected inside six experimental tanks (each condition was replicated in three tanks). Offshore aquaculture noise conditions were recreated as the typical acoustic field in proximity of an offshore sea cage for fish farming using a random sequence of quiet sea background and boat noises. The acoustic field inside an onshore open concrete tank for fish farming represented the onshore aquaculture noise conditions. The other three tanks were used as a control condition without acoustic projection. The weights and lengths of fish exposed to offshore aquaculture noise were higher than the specimens in the control and onshore aquaculture groups. Moreover, higher levels of serum cortisol, glucose, red blood cell count, haematocrit value and haemoglobin content and lower levels of white blood cells were recorded in fish groups from the control and onshore treatments. Reactive Oxygen Metabolites (ROMs) and Total Antioxidant Capacity (TACs) of fish exposed to the boat acoustic condition after 40 days showed a significant increase compared to those of fish of control group. After 80 days lower values of TACs were recorded in the boat acoustic condition compared to control and on-shore aquaculture acoustic condition.
These results allow us to hypothesise that offshore aquaculture noise and the sea soundscape in particular positively influence growth performance and could reduce stress and improve the welfare of the sea bream.


Kevin Fish of Green Island Cement and Hans Jorgen Nielso of LV Technology describe modifications to the company's vertical mill at the plant in Yun Fu City, and the subsequent increase in output.


Image deblurring can improve visual quality and mitigates motion blur for dynamic visual inspection. We propose a method to deblur saturated images for dynamic visual inspection by applying blur kernel estimation and deconvolution modeling. The blur kernel is estimated in a transform domain, whereas the deconvolution model is decoupled into deblurring and denoising stages via variable splitting. Deblurring predicts the mask specifying saturated pixels, which are then discarded, and denoising is learned via the fast and flexible denoising network (FFDNet) convolutional neural network (CNN) at a wide range of noise levels. Hence, the proposed deconvolution model provides the benefits of both model optimization and deep learning. Experiments demonstrate that the proposed method suitably restores visual quality and outperforms existing approaches with good score improvements.