The rise of online courses enriches the traditional curriculum elements, reconstructs the traditional curriculum model, and provides more learning channels for learners. However, the current qualities of online courses are uneven. The teaching process is still in a single direction of flow and the effectiveness of the courses can't be guaranteed. By enabling interaction can qualities of online courses be guaranteed. We should be familiar with the course content and understand the interactive characteristics and the factors affecting the interaction. Thus, we can reconstruct the course objectives, reorganize the course content, re-engineer the implementation process, reform the course evaluation, so as to ensure the meaningful interaction.


NAC are specific novel transcription factors in plants with multiple biological functions,which play an important role in growth and development,stress resistance,and hormonal regulation of plant. In this study,the MsNAC1(JN099384􀆰 1)gene in Medicago sativa L. was obtained by rapid amplification of cDNA ends(RACE)meth⁃ od. Bioinformatics analysis showed that MsNAC1 had an open reading frame(ORF)of 993 bp,encoding a stable,wa⁃ ter⁃soluble protein with 330 amino acids. The MsNAC1 protein had the basic characteristics of the NAC transcription factors including conserved NAM domain in the N⁃terminus and highly divergent C⁃terminus. It was predicted to lo⁃ cate in the nucleus with 2 nuclear localization sequences,and contained 9 glycosylation sites and 23 phosphorylation sites. The tertiary was symmetrical homodimer. Sequence alignment analysis revealed that the structure of MsNAC1 was predicted to have high homology with ATAF1 in Arabidopsis thaliana and OsNAC6 in Oryza sativa. Phylogenetic analysis revealed that MsNAC1 was a member of NAC transcription factor family belonging to ATAF subgroup,and had most close genetic relationship with ATAF1. The expression of MsNAC1 under abiotic stresses was analyzed by qRT⁃PCR,its expression levels increased at first but later decreased under high⁃salinity,drought,and cold stress 6 期 申玉华等:紫花苜蓿 NAC 转录因子 MsNAC1 基因的克隆、生物信息学分析及非生物逆境胁迫下的表达分析 treatments. The difference among different treatment times were significant at 0. 01 level,and the expression level in root was higher than that in leaf which indicating that this gene might participate in regulation of plant abiotic stress response.


Make use of combination of assemble lens and columns lens to produce light veins of 35~40 mm length and 1 mm width which is thrown to weld seam.Thermistor composes of bridge type electric circuit which contols temperature automatically.The rate of flowing of 5 L/s blows fumes,steam and splash thing etc.Minni CCD is added narrow tape filter light plate to take picture,through image processing such as 2 value melting,image cutting,central sampling and calculate deviation to send to control system,which guides crawling robot to weld correctly.


C-V-characteristics of ZnO-based heterostructures were modeled. Influence of annealing technology and contacts material on structure characteristics was investigated. Empirical dependence of the surface potential in silicon on the applied voltage on the structure was derived.


Multiple frame surveys are commonly used for a variety of reasons, including correcting for frame undercoverage , increasing precision of estimation of population parameters for groups of interest, targeting rare populations and reducing survey costs. Several approximately design unbiased estimators have been proposed for inference from multiple frame surveys. It has been shown that most of the existing estimators can be generalized as a class of Generalized Multiplicity-Adjusted Horvitz -Thompson Estimators. We develop an Empirical Likelihood approach to the Multiplicity-adjusted estimator. The proposed estimator allows for several multiplicity adjustments. It can handle auxiliary information and can be applied to a variety of parameters of interest expressed as unique solutions to estimating equations. Under certain sampling designs, Wilks -type confidence intervals can be calculated without variance estimates.


This population-based study examines the risk of being diagnosed with thyroid cancer in long-term follow-up of individuals with benign thyroid biopsy results.


We are investigating the molecular basis of low temperature responses in apples, by identifying and characterising fruit genes which show altered expression in response to cool-storage, Two independent cold-regulated clones (pAMTI and pAMT2) were isolated from a cDNA library derived from cool-stored apple (Malus domestics Borkh. cv. Granny Smith) fruit. These clones share only 27% amino acid identity with each other, but both show high similarity to plant metallothionein (MT)-like proteins. The polypeptide encoded by pAMTI shares similarity with type 2 MT-like sequences, while that encoded by pAMT2 is similar to others which share a different distribution of cysteine residues. We suggest, these form a 'type 3' group of MT-like clones. Genomic Southern analysis confirmed that there is a family of MT-like genes in apple. There are differing patterns of pAMTI and pAMT2 expression during apple fruit development, amt 1 RNA was abundant in flowers and during the early stages of development, and decreased as the fruit approached maturity, while amt2 RNA was barely detectable in flowers and young fruit and accumulated with fruit development. In ripe fruit. amt 1. expression was up-regulated, while amt2 expression was down-regulated. In leaves, both genes showed increased expression with leaf age. In Granny Smith, Cox's Orange Pippin and Braeburn apple cultivars. both genes were up-regulated in cool-stored fruit. In Granny Smith contical tissue, amt RNA levels were elevated within the first 45 min at both 0.5°C and 4°C, but not at 12.5°C. The different patterns of amt1 and amt2 expression during fruit development and in different tissues suggest that the respective genes have distinct controlling elements and may be functionally different. The in vivo roles of the encoded polypeptides, particularly in relation to chilling tolerance or acclimation, are as yet unknown.


In order to support its economic development, Romania offers various stimuli to investors, in accordance with European law. Recently, the Department for Infrastructure and Foreign Investments was established. It benefits from support from the Romanian state and encourages investors to come here and invest in areas such as: environment, energy, research, etc. In their turn, foreign investors analyze several factors and make various analyses between states. These interest factors are: costs with constructions and land, labour, the fiscal system, human resources, infrastructure, etc. Concerning the interest factor in Sibiu, manifested through the potential investors, the county is an interesting prospect for foreign investments. It is a known fact that FDIs create both positive and negative effects. Due to the fact that foreign investments are economic activities which take longer periods of time and which require considerable financial and human resources, they generate risks. In order to avoid risks, local administrations and governments in host countries must respect their promises.


By examining the Laplace Transform of any time evolution we discover a lot of anticipatory indications. In consequence we were stimulated to collect all the possible introspection procedures laying on the Laplace space. In technology the storage components supply technologic memories and introduce poles and zeros in the Laplace space. We consider the root loci branches as forecasting channels describing the system evolutions and from this point of view we conceive a complex anticipation space. From the root loci we deduce the asymptotic star subspaces to condense the {s} spaces into a ridge star. The suited Cauchy relation allows to collect and to displace the informations flows thoughout this anticipation space and assumes the operational coherence. Pairs of conjugate heliphasors corresponding to ωk and −ωk frequencies are introduced for detecting the damping or amplifications of any oscillating components. Their intersections with the root locus point out the frequency variations as consequence from sys...


The human environment contains more than 50 metals or elements similar to metal. 15 of these are trace elements which have among others with zinc, calcium, copper, magnesium and iron important functions in the morphogenesis of the skin. This review deals with the supposed role of metal ions in the skin, their concurrence for carrier proteins and membrane receptors. It is shown, that the equilibrium of trace metal ions can possibly be critical for the intact skin as well as for repair mechanisms. Xenobiotic ions may influence this balance and cause a pathological change. The skin is an organ which can remove superfluous trace elements and xenobiotic ions from the body. These mechanisms vary with the different metal ions. Metal ions are important causes of allergies, the majority of metals and metal compounds can induce allergic changes. Chrome and nickel are the best known and most effective human allergens. Cytological and epidemiological tests showed a carcinogenic effect of chrome, nickel and other metals like cadmium, lead and gold


Abstract The unusual new Neotropical genus Exalla is described and illustrated, along with three new species, E. browni, E. macalpinei, and E. shewelli. A key to the species is provided. The species are known from wet montane rainforest habitats in Colombia and Ecuador at elevations above 1500 m.


In galaxy clusters, the intracluster medium (ICM) is expected to host a diffuse, long-lived, and invisible population of "fossil" cosmic-ray electrons (CRe) with 1–100 MeV energies. These CRe, if reaccelerated by 100× in energy, can contribute synchrotron luminosity to cluster radio halos, relics, and phoenices. Reacceleration may be aided by CRe scattering upon the ion-Larmor-scale waves that spawn when ICM is compressed, dilated, or sheared. We study CRe scattering and energy gain due to ion cyclotron (IC) waves generated by continuously driven compression in 1D fully kinetic particle-in-cell simulations. We find that pitch-angle scattering of CRe by IC waves induces energy gain via magnetic pumping. In an optimal range of IC-resonant momenta, CRe may gain up to ∼10%–30% of their initial energy in one compression/dilation cycle with magnetic field amplification ∼3–6×, assuming adiabatic decompression without further scattering and averaging over initial pitch angle.


Provided are an information reporting method and device. The method comprises: when a user equipment (UE) sends, to a base station, a confirmation that RRC connection establishment is completed, RRC connection re-establishment is completed or RRC connection recovery is completed, the UE reporting, to the base station, capability information and/or preference indication information for indicating a data transmission mode about the UE. The present invention solves the problem in the relevant art that an eNodeB cannot acquire the capability of the UE caused by the fact that the transmission optimization scheme support capability of the UE and a preference indication are stored in an MME and are not visible to the eNodeB.


William Jay (1769-1853) was an Independent minister of the Argyle Chapel in Bath for sixty-two years. His career bridged the time between the Evangelical Revival of the eighteenth century and the formal Congregational denominationalism of the nineteenth century. Jay's autobiography is used among historians for its first-hand accounts of other notable evangelical figures such as William Wilberforce (1759-1833), Hannah More (1745-1833) and John Newton (1725-1807). Too often his own influence has been overlooked, but at the time he was regarded as one of the foremost Dissenting preachers of his era. His ministry within a fashionable spa city increased the respectability of evangelical religion among the growing middle classes in Bath. This thesis examines the evangelicalism of William Jay in the context of his times.
 The scope of Jay's life and popularity will be examined in six chapters. Following the introduction, chapter two will examine his direct impact through the Argyle Chapel upon Bath. Chapter three will review the early life of William Jay that was much neglected by his biographers. It will demonstrate the formation of his evangelicalism first introduced to him by Joanna Turner (1732-1784) and instilled in his training by Cornelius Winter (1742-1807). The social composition of the Argyle Chapel will be evaluated in the fourth chapter. Those that Jay attracted to the chapel not only promoted his cause to advance the gospel, but also increased the prestige of the minister and his place of worship. In chapter five, Jay's preaching, which attracted celebrity and commoner alike, will be analyzed for form, style, content, delivery and the receptivity of his audience. Likewise, the spirituality of the man, which will be reviewed in chapter six, induced similar qualities to stimulate evangelical religion. Finally, the polity and ecclesiology of William Jay will be examined in the seventh chapter. The Argyle Chapel was under strong pastoral guidance for the vast majority of the minister's service until Jay lost that influence shortly before his retirement in 1852. The biography will conclude with an appraisal of R.W. Dale's (1829-1895) categorization of Jay and his chapel as representative of older evangelical religion and criticism of the early participants of the revival found in Dale's sermon The Old Evangelicalism and the New (1889). William Jay promoted a religious perspective that exhorted the individual to dwell on the self yet sought to do so through a united Christian movement that crossed denominational barriers.


The Northern Bald Ibis (Geronticus eremita) once bred in mountains throughout the Mediterranean, but it is now restricted to southwestern and southeastern corners of its former breeding range. In the past, the species occurred north to the Danube; the northernmost confirmed breeding records came from Thuringia, Germany. Here I review historical evidence of the occurrence of the Northern Bald Ibis in the Czech Republic, Poland and Slovakia. I found that the reports either had no evident relation to local faunas, or that the authors had other bird species in mind. Recent suggestion by Hudecek & Hanak (2004a,b) that Northern Bald Ibises were recorded in the Czech Republic in the late 8th and perhaps even in the early 9th centuries was rejected.


From the introduction : "Artificial intelligence in education comes of age in systems now called "intelligent tutors", a step beyond traditionnal computer-assisted instruction. Computer-assisted instruction evolves toward intelligent tutoring systems (ITSs) by passing three tests of intelligence. First, the subject matter, or domain, must be "known" to the computer system well enough for this embedded expert to draw inferences or solve problems in the domain. Second, the system must be able to deduce a learner's approximation of that knowledge. Third, the tutorial strategy or pedagogy must be intelligent in that the "instructor in the box" can implement strategies to reduce the difference between expert and student performance. At the foundation of ITSs, therefore, one finds three special kinds of knoweldge and problem-solving expertise programmed in a sophisticated instructional environment. This book examines these knowledge foundations - expert knoweldge, student diagnostic knowledge, and the instructional or curricular knowledge - in detail. This book also describes (a) how these kinds of knowledge are embodied in computer-assisted instructional environments; (b) how these systems accrue the advantages of advanced computer interface technologies; (c) how ITSs will emerge in the real world of complex problem solving; and finally (d) how researchers must learn to evaluate the effectiveness and overall quality of these dynamic systems in a world where one day machine tutoring will be taken for granted. The purpose of this chapter is to introduce the major research issues and development themes that the primary authors - John Anderson, Kurt VanLehn, Henry Halff, Richard Burton, James Miller, William Johnson, David Littman, and Elliott Soloway - explore and amplify." (http://books.google.fr/books?id=d2NljA18AOIC&lpg=PP1&dq=intelligent%20tutoring%20systems%20polson&hl=fr&pg=PA1#v=onepage&q&f=false)


Bearing capacity factor Nγ and shape factor were studied for rigid strip and circular footings with a rough base on sand by numerical modelling considering the effect of dilation angle. The numerical model was developed with an explicit finite difference code. Loading procedures and interpretation methods were devised in order to shorten the running time while eliminating the exaggeration of the reaction caused by the explicit scheme. Using the Mohr-Coulomb plasticity model with associated ( ) and nonassociated ( ) flow-rules, the bearing capacity factor  was evaluated for various combinations of internal friction angles and dilation angles. Bearing capacity factor decreased as the dilation angle was reduced from the associated condition. An equation applicable to typical sands was proposed to evaluate the relative bearing capacity for the nonassociated condition compared to the associated condition on which most bearing capacity factor equations are based. The shape factor for the circular footing varied substantially when the plane-strain effect was taken into account for the strip footing. The numerical results of this study showed closer trends with the previous experimental results when the internal friction angle was increased for the strip footing. Discussions are made on the reason that previous equations for the shape factor give different results and recommendations are made for the appropriate design shape factor.


The isotopic variation of glacial runoff from the Dzhan Kuat glacier (Central Caucasus) during the 2013 summer season is described. The season was abnormally rainy with resulting non-typical form of theDzhanKuatRiverhydrograph. The contribution of melting glacier ice to the total runoff was qualitatively assessed. Studying the input of glacial melt water into the runoff is a key element of integral hydroclimatic approach to the monitoring of glacier basins. In summer 2013 the δ18O of theDzhanKuatRiverwater varied from –15,04‰ in June to –11,27‰ in September. The basic component of runoff in the end of ablation season has δ18O –11,9‰. Low values of δ18O (–14…–15‰) for the glacial runoff in June correspond to the melting of isotopically light winter and early spring snow and glacier ice. The growing δ18O values of river water (more than –12‰) in September probably indicate a predominant role of subglacial water and groundwater in runoff formation during the period of decreasing intensity of ice ablation. Daily isotopic variations of runoff are negligible.


By constructing best-reply correspondence and using kakutani-Fan-Glicksberg fixed point theorem, this paper establishes the existence of the system of real vector equilibrium problem and deduces the existence of essential components under best-reply correspondence topology. Finally, as a special case, the existence of essential components of the solution set for Nash equilibrium problems is established.


FRP(Fiber Reinforced Plastic) is a composite material for glass or carbon reinforcements with resin. In the heat forming method of FRP, residual stress occurs due to discrepancy of different thermal expansion. Since it is known that process-induced residual stress influences behavior of matrix cracks generated in operation, accurate estimation of the residual stress is an important issure for FRP manufacturing. For thermoset-based FRP, the residual stress may result from curing shrinkage as well as thermal deformantion. However, the residual stress caused by cure reaction has been hardly studied and then the effect of molding temperature pattern on the residual stress has not been cleared. In the present syudy, FEM analysis was performed to evaluate the molding processinduced strain occurred in reinforcement fibers on the assumption of viscoelastic properties of resin depending on the degree of cure. In addition, model specimens of glass optical-fiber reinforced polymers were manufactured for in-situ evaluation of process-induced strain by embedded FBG (Fiber Bragg grating) sensors.


W e present the first described procedure of transpatellar retrograde femoral nail insertion for treatment of femoral shaft fractures in two patients with fixed flexion deformities of the hip and knee joint. The decision to proceed with this technique was made because of the difficulties in treating these fractures with conventional methods in the presence of hip and knee ankylosis. Both patients had a low level of function preoperatively and went on to make full recoveries after an early discharge from the hospital.


In this work, ray tracing (image method) simulation results were reported inside an ideal open-trench environment at 2.4 GHz. Understanding the propagation environments in this drain under various conditions such as dry or with water flow is a practical approach that can contribute to accurate propagation prediction, which is helpful for the design of wireless communication systems in environments where such open-trench drains exist. When water is present inside the open-trench drain, the ground-reflected ray from the water surface is relatively stronger compared to when the drain is dry.


Integrated chip‐level photonics has the potential to revolutionize future computer systems by eliminating the "von‐Neumann information bottleneck" and the power losses resulting from the use of electrical interconnects. Yet, the need for optical‐to‐electrical conversion has so far hindered the implementation of chip‐level all‐optical routing schemes, which remain operational without continuous power consumption. Here, a crucial component to successful implementation of such all‐photonic networks is demonstrated – an effective, practicable all‐optical nonvolatile switch. Current integrated all‐optical switches require constant bias power to operate, and lose their state when it is removed. By contrast, our switch is entirely nonvolatile, with the direction of light flow altered by switching the phase state of an embedded phase‐change cell using 1 ps optical pulses. High on/off switching contrast devices are achieved that are fully integrated and compatible with existing photonic circuits. It is shown that individual switching events occur with transition times below 200 ps and thus hold promise for ultrafast light routing on chip. The approach offers a reliable and simple route toward hybrid reconfigurable photonic devices without the need for electrical contacting.


It has been shown that an homologous rabbit carcinoma enhancing material 1 , 2 failed to enhance a carcinoma of the mouse. 3 Haaland, 4 Leitch, 5 and Casey 5 have demonstrated, however, that a material can be obtained from the same mouse carcinoma (No. 63) which will enhance both the incidence and the growth of the primary tumor when used in conjunction with the tumor inoculation. It seemed desirable, therefore, to determine whether homologous enhancing materials will enhance heterologous transplanted tumors within the same animal species. Since other transplantable rabbit tumors are not available, the experiments were carried out with mouse tumors. In the 2 experiments here reported the enhancing material was obtained from the Bashford mouse carcinoma (No. 63) and its effect was observed in connection with implants of mouse sarcoma (No. 180). Two different batches of preserved (enhancing) material and sarcoma emulsion were used; 60 mice of the Rockefeller Institute strain were employed; in the first experiment, there were 40 females and in the second 20 males. Thirty of these mice were injected with a saline emulsion of Bashford mouse carcinoma (No. 63) tissue which had been preserved anaerobically at 24°F. for 42 days. 3 Two weeks later the entire 60 mice were inoculated into the left groin with 0.09 cc. of an emulsion (10 parts saline, 1 part tumor) of fresh mouse sarcoma (No. 180). Measurements of the local growths were made at 6, 12, and 16 days. The ulceration of many tumors after this time precluded further measurements. For the sake of clarity the mice treated with the preserved carcinoma material and later inoculated with the sarcoma are called the "experimental" mice, and the mice inoculated only with the sarcoma the "control" mice.


The {tau}{sup -} {yields} {pi}{sup -}{pi}{sup -}{pi}{sup +}{pi}{sup 0}{pi}{sup 0}{nu}{sub {tau}} and {tau}{sup -} {yields} 3h{sup -} 2h{sup +} {nu}{sub {tau}} decays have been studied using the BABAR experiment at the PEP-II e{sup +}e{sup -} storage ring. Preliminary branching fractions are given for the {tau}{sup -} {yields} {pi}{sup -}{pi}{sup -}{pi}{sup +}{pi}{sup 0}{pi}{sup 0}{nu}{sub {tau}} and to the sub-channels {tau}{sup -} {yields} {eta}{pi}{sup -} {pi}{sup 0}{nu}{sub {tau}} and {tau}{sup -} {yields} {omega}(782){pi}{sup -}{pi}{sup 0}{nu}{sub {tau}}. A preliminary upper limit is given on the branching fraction for the {phi}(1020){pi}{sup -}{pi}{sup 0}{nu}{sub {tau}} mode. In addition a preliminary measurement of the branching fraction of the {tau}{sup -} {yields} 3h{sup -}2h{sup +} {nu}{sub {tau}} decay (h = {pi}, K) is presented.


This paper aims to produce an instrument of observation in the selection of meaningful approach to assess children's science process skills. This instrument has four categories. First of all, the use of the type of approach encompasses the approaches of learning through play, thematic, integrated, mastery, contextual and project. Secondly, the suitability of the selection of approach encompasses relevance, parallelism, engaging. Thirdly, meaningful teaching encompassing the interaction or discussion, stimulation, involvement, curiosity and questioning and answering. Fourth, children's science skills activities that cover problem solving, reasoning, looking into the process, analytical, inquiry and reflection. Every item in every category has four Likert scales. It is hoped that these items of observation develop can be used to assess the children science process skills.


From the point of view while playing three pieces of Albeniz Iberia Book II, from general to specific, this thesis first explores Spanish folk music elements behind the rich content of the text in order to reveal the essence of Spanish music—the development and musical feature of flamenco, which is the foundation to interpret the work. Investigating the musical background and different phases of the composer as the following agenda makes the context of Iberia traceable to the players. Musical analysis includes the relevance and commonality among the three pieces and discusses how Albeniz utilized Spanish folk music elements and how he composed in details. Performance Practice talks about the author's own observation on aspects of tempo, texture, phrasing, articulation, dynamics and sonority.


The Ouachita-Marathon fold and thrust belt has a foreland region in Texas, Oklahoma, New Mexico, and Colorado which was deformed in a style reminiscent of the Laramide foreland in Wyoming and Montana. Large, asymmetric basins are separated by basement block uplifts which were subaerially exposed and eroded during Pennsylvanian and early Permian time. A major, previously unrecognized aspect of this deformation is the regional subsidence which resulted in burial of the uplifts. Analysis of the subsidence history for three basins suggests that crustal extension was not a factor in affecting regional subsidence. This suggestion is in agreement with the presence of a thick crust and reverse and thrust faults in the region. A model is proposed in which northward-directed, low-angle subduction places oceanic lithosphere converted to eclogite beneath the foreland. Resulting isostatic adjustments would have created tectonic subsidence of the same order of magnitude as that observed in the Ouachita foreland.


To the Editors: Cysticercosis, caused by cysticercus cellulosae, the larval form of Taenia solium, is potentially a dangerous systemic disease with variable clinical manifestations, depending on the sites in which cysticerci are found. The disease most commonly involves subcutaneous and muscle tissue, followed by the eye and brain. Laboratory tests used in its diagnosis include serologic tests such as enzyme-linked immunosorbent assay and enzyme-linked immunoelectrotransfer blot, traditional radiography and newer imaging modalities, such as computed tomography and magnetic resonance imag-


Foreseeable income reductions around retirement should not affect aggregate consumption. However, given higher leisure endowments after retirement, theory also predicts lower consumption of leisure substitutes. To avoid misinterpreting this predicted drop as a puzzle, our novel approach focuses on housing consumption (complementary to leisure in utility) and controls for leisure changes. In Germany tenants represent roughly half of all households, making many housing expenditures directly observable in micro data. We find significant negative impacts of the retirement status on housing consumption, which is hard to reconcile with life-cycle theory. Despite the lock-in nature of past housing decisions, income reductions at retirement have additional – though small – effects on housing.


A 10-year fencing experiment in the eroded grassland, type C, of the Bogong High Plains has established the value of the point analysis method for the quantitative study of continuing change in vegetation. The results show that the exclusion of cattle from this widespread type of subalpine grassland results in a gradual improvement in the amount of vegetative cover, especially in that provided by the herb Celmisia. Over the 10-year period there have been striking soil changes in the fenced plot, resulting in an increase in organic matter and in field capacity, and a significant decrease in bulk density. These findings enable one to make recommendations on catchment management in this area. They have also led to the hypothesis that the eroded grassland has been derived from a herb-field similar to that still existing in the higher parts of the area.


We performed a deep JHK' survey of the 2.9 arcmin2 positional error box of the gamma-ray burst (GRB) 790418. At limiting magnitudes of J ~ 21, H ~ 20, and K ~ 19, we find about 20 objects within the box, galaxies as well as very red stars. A relatively bright galactic nucleus (K = 16.3), presumably the bulge of a spiral galaxy, is located about 5'' outside the 3 σ box given in Vrba, Hartmann, & Jennings, with its halo region possibly extending inside the box. Although this seems to match well into the framework of the cosmological model of GRBs, the assumption that this galaxy is physically related to GRB 790418 is not strongly supported by simple statistical arguments. No potential Galactic halo burst source could be selected from our data.


A series of reports about pro-angiogenic and procancerogenic activity of thyroids hormones (TH) and its analogues sold through nongenomic action. The nongenomic actions of TH require a plasma membrane receptor or nuclear receptors located in cytoplasm. The plasma membrane receptor is located on integrin ?V?3 at the Arg-Gly-Asp recognition site important to the binding by the integrin of extracellular matrix proteins. TH differ in their ability to influence the ?V?3: L-thyroxine (T4), linking through the main site of the receptor, it activates mainly mitogen-activated protein kinase (MAPK; ERK1/2) and 3,5,3'-triiodo-L-thyronine (T3) binding by other site affects to phosphatidylinositol-3-kinase (PI-3-K). This messengers transduce the hormone signal into complex cellular/nuclear events including increased expression of basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), hypoxia-induced factor 1-? (HIF-1?) and consequent leads to activation of angiogenesis and cell proliferation. Treatment of cell with thyroid hormones caused expression of inflammation-associated genes: cyclooxygenase-2, matrix metalloproteinase-9. Tetraiodothyroacetic (tetrac) blocks thyroid hormone effects on angiogenesis and cancer cell proliferation.


ABSTRACT The role of digitally mediated networked publics in the co-production and negotiation of contemporary masculinities has not been widely researched in an African context. This paper explores networked masculinities on South African Black Twitter via the hashtag #MensConference, a fictional conference organized by men as a humorous rejection of Valentine's Day. Drawing on a critical thematic analysis of a selection of tweets through the lens of critical masculinity studies, we uncover a wide range of masculinity discourses under the hashtag, across the traditional-liberal spectrum. While expressions of sexism and misogyny were widespread throughout the sample, men also upheld alternative and progressive models of manhood. The affordances of social media provided men with a space to express themselves, but also to police and contest notions of masculinity through in-group dynamics that worked to reinforce patriarchal hegemony. However, the interactions between black South African men on Twitter were defined by their specific social, economic and cultural context. The analysis demonstrates the critical role of social media, and Black Twitter in particular, as a key vehicle for both the reproduction and contestation of hegemonic masculinities in South Africa.


Upper airway infections are one of the most common causes of medical appointment in clinical practice mainly faced by pediatric population.1 According to a study conducted by Morais et al.2 the incidence of respiratory tract infections due to β-hemolytic streptococcus can be more than 18times higher in children attending some day care center or environments where they are close to others sharing belongings. However, individuals of all ages are susceptible to propagation of this microorganism under conditions of overcrowding, because the interpersonal dissemination of these bacteria occurs through aerosolized microdroplets and/or by direct contact, mainly in environments where there are clusters of people. Among the diseases that affect the upper airways, acute pharyngitis (AP) is one of the most frequent in children. Although most of the AP is of viral origin, Group a Streptococcus Beta-hemolytic (EBHGA) presents as a significant bacterial etiological agent diagnosed in about 15-30% of acute pharyngitis.3 EBHGA or Streptococcus pyogenic is grampositive aerobic bacteria that causes a variety of infectious syndromes4 and is considered of great clinical interest due to its high pathogen city, usually involving or pharynx and skin, as a consequence these bacteria may cause several inflammatory diseases. One of the main laboratorial characteristics this pathogen presents to be identified and classified is the ability to shatter completely red blood cells in 5% sheep blood culture, causing a transparency in the culture medium, which is called Beta-hemolytic.5 Streptococcus pyogenic is important when compared to groups B, C and G, not only because it is the main etiological agent of streptococcal pharyngitis,6 but also because it causes suppurate complications such as, cervical adenitis, peritonsillar abscess, retropharyngeal or cervical abscess.7 In addition, EBHGA is related to other diseases such as streptococcal toxic shock syndrome, necrotizing fasciitis, scarlet fever and skin infections.8 According to Areas et al.9 its main complications are acute rheumatic fever, rheumatic heart disease and acute streptococcal disease, with a higher incidence especially in developing countries. Therefore, the early diagnosis of this condition, followed by adequate antimicrobial treatment, is extremely important not just for the prevention of rheumatic fever (RF) and other pathologies, but also for the reduction of EBHGA transmission among patients.3 Living in restricted settings, such as day care centers and schools, can greatly influence the dissemination of these bacteria, placing the health of children and adolescents at risk,10 considering that children and teenagers or pharynx is very sensitive to EBHGA infections, especially among 5 And 15years of age.11 Besides that, they can carry pathogenic microorganisms without presenting symptoms, characterizing the asymptomatic carriers. The epidemiological profile of this pathogen shows the relevance of it's diagnosed due to the existence of complications it may cause and their ease of transmission.2 Therefore, a precise etiological diagnosis contributes to avoid the abusive use of antibiotics and its consequences as the increase of bacterial resistance.12 This study aimed to determine the prevalence of Group A β-hemolytic streptococcus in or pharynx of asymptomatic children who attend a public school and also the sensitivity and resistance profile of these bacteria to main antibiotics tested.


Objective To investigate the effects of Rapamycin on the growth and apoptosis of human prostate carcinoma cell line PC-SM-21M. Methods The inhibitory effect of Rapamycin was observed at 100,200,400,800μg/L on the growth of human prostate carcinoma cell line PC-3M-2B4 in serum-free medium for different concentrations by methyl thiazol tetrazolium (M3W) assays. Flow cytometry (FCM) analysis was used to study the changes of cell apoptosis. The expression level of bcl-2 and bax was determined by Western blotting. Results Rapamycin caused dose-dependent inhibition on the growth of human prostate carcinoma cell line PC-3M-2B4 in a concentration-and time dependent manner. Rapamycin induced the apoptosis of PC-SM-2B4 cells in a concentration-dependent manner. The levels of bcl-2 protein were reduced gradually with the increase of concentration or action time. Conclusion Rapamycin, a mTOR inhibitor, inhibits the growth of human prostate cancer cell and induces apoptosis of human prostate cancer cell. mTOR might be a potential target for anti-prostate cancer.

Key words:
mTOR;  Rapamycin ;  bcl-2 ;  Apoptosis ;  Signal pathway


The study of multiobjective optimization problems, such as resources, time limits, and cost based on network planning, can lead to an intelligent construction plan, which is very important for improving the comprehensive benefit of the project. In this article, a multiobjective static network planning optimization (i.e., sNP-RTC) model is proposed to integrate the heuristic local search algorithm and adaptive operation to improve the multiobjective particle swarm optimization (MOPSO) algorithm to solve the comprehensive "resource–duration–cost" optimization problem. The results show that this algorithm can achieve a unified and comprehensive Pareto frontier compared with the genetic MOPSO, providing a new method for solving resource–duration–cost optimization problems. Moreover, a dynamic "resource–time–cost" problem model for dynamic network planning (i.e., dNP-RTC) is presented and applied to improve the multiobjective subgroup algorithm to solve the model in real time after updating the network planning parameters. Compared with the static problem, the model increases the flexibility of problem solving, is more in-line with engineering practice, saves more cost in work scheduling, and has more application value for actual project scheduling.


Review of John Beldon Scott: 'Architecture for the Shroud: Relic and Ritual in Turin' (University of Chicago Press: Chicago and
London, 2003).


The mathematical analysis employed in this study constitutes an essential foundation for a broader investigation into the regularity of the Navier-Stokes Equations. Within this context, this work represents a significant advance with the Smagorinsky model integrated into the LES methodology. Using the Banach and Sobolev functional spaces, we developed a new theorem that points out a path towards the creation of an anisotropic viscosity model, formulated in the present work. Initially, our effort focuses on providing a comprehensive mathematical analysis, with the aim of promoting a deeper understanding of the challenge inherent in the regularity of the Navier-Stokes equations.


A new concept of SAW powered lab on chip able to actuate and to perform accurate sensing is presented. Using IdT/ZnO/IdT/Quartz structure, it is possible to obtain simultaneously Rayleigh and Love waves. The first wave will be used to mix or heat whereas the second one will be use to sense. In order to determine the optimal characteristics, a theoretical approach has been developed. A comparison between our former classical microfluidic device and the new structure is presented. First results are explained.


Given the prodigious amount of scholarship on Platonic love, this article explores a different question: the nature of Plato's love for Socrates as expressed in two dialogues, the Symposium and Phaedo, in which Plato depicts Socrates as surrounded by his lovers and disciples. By paying attention to the "outer frames" of the dialogues, that is, the relationship between the text and the reader, it is argued that Plato's love for Socrates is displayed not only in his loving depiction of Socrates but also in Plato's doing philosophy through the character of Socrates; Plato thereby shows what genuine love for Socrates would be like. Moreover, contrasted with the words and actions of other characters in these dialogues, Plato shows himself to be not just one among many of Socrates' lovers, but in fact the best.


resented "live" throughout the 4001 Berri building in Montreal, CounterPoses: Reimagining the Tableau Vivant enabled visitors to reflect on the conditions that would make it possible to take the viewer into account-I mean in a way that would be slightly more critical than the constant appeals that we are now (at a time when interactivity has become widespread and banal) subjected to, on the pretext that we will be better served (or subjugated). The idea for this weekend originated with the collective Display Cult (Jim Drobnick and Jennifer Fisher). With a name like this, it should come as no surprise that it chose to measure itself against the medium of the exhibition; indeed it should be praised for using this opportunity to reinvent in a meaningful way a genre that had fallen into disuse with the arrival of the twentieth century. I am referring to the tableau vivant.


Teaching content is an important carrier to achieve the course teaching objectives, and the training of excellent teachers cannot be separated from high quality teaching content. The course English Instructional Design for Primary Schools was taken as an example to discuss the theoretical basis of the optimization and reconstruction of teaching content in universities. Practice has proved that the reconstructed teaching content in the course English Instructional Design for Primary Schools not only effectively improved the teaching quality of the course, but also significantly improved students' ability of solving problems.


Bis(methylphenylglyoximate)cobalt(III) complexes exist both as cis and trans isomers due to the asymmetry of the equatorial ligand, and, when the axial ligands are different, the trans isomer is chiral. The reaction of racemic trans-[CH3Co(mpgH)2py] (1) with either 3- or 4-pyridylboronic acid affords dimeric units arranged on a crystallographic symmetry center such that the pyridyl nitrogen of one moiety coordinates to the Co atom of the symmetry-related unit. In principle, three structurally different dimeric species (two homodimers and one heterodimer) can be obtained. Time-resolved 1H NMR spectra of a 1:1 mixture of racemic 1 and either 3- or 4-pyridylboronic acid in CDCl3/CD3OD show that the reaction does not converge toward a unique species in solution. Nevertheless, X-ray structures show that the heterochiral dimers are the only products that crystallize from the reaction mixture. The nature of the dioximate side groups does not affect the geometry of the dimeric arrangements assembled by 4-pyridylboronic acid ("molecular box"). On the contrary, the geometry of the species assembled by 3-pyridylboronic acid varies from the "molecular parallelogram" obtained from the bis(dimethylglyoximates) to the highly squeezed "molecular box" obtained from bis(methylphenylglyoximates). Cyclic voltammetry studies show that the metal centers in the dimeric species do not interact with each other and undergo a simultaneous redox process. However, depending on the geometry of the systems, the redox process involves a single four-electron reduction for 3 and 5 or two consecutive two-electron reduction steps for 4 and 6. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)


Science and technology  for vegetable farmer groups in Giri Mulyo Village, Kayu Aro West Sub District, Kerinci District partnered with Bina Harjo and Sejahtera Farmer Group, based on quality and soil fertility problems for optimum productivity.  The solution offered were the application of "Site-specific   of   Potato   Agrotechnology"    through   increased   of   farmers   knowledge   and understanding  of their soil characteristics,  conditions and problems and plots demonstration.  The potato agrotechnology included application of : 1) planting of potato on ridges across the slope, 2) deep tillage to improve the soil physical condition,3) Dolomite lime (1 ton/ha), animal manure (10 tons/ha),  and 4)biological fertilizers (200 kg/ha) to improve the nutrients availability especially N and  P,  5)rock  phosphate  (slow  release  fertilizer)  (360  kg/ha),  and  6)  others  crop  cultivation techniques as recommended (quality potato seed, proper spacing, balanced doses of chemical fertilizers). The farmers' responses were quite high, especially due to gain knowledge and understanding  of the management  of land  and  potato  crops,  and  good  quality  of potato  seed. Farmers  were  hoping  further  activities  especially  on  a  regular  basis  for  the  development  of coaching a group of farmers in highland vegetable farming (especially potato) K eyw ords: potato, agrotechnology, animal manure, biological ferrilizer, rock phosphate


him present O _ ho _ ri stories suggested oral evidence made better fiction than history. He has, by this time, shown the opposite to be true by using oral evidence to unearth complex categories of actors and to expose the limitations of colonial documentary evidence. Still, the author's candour about this feedback raises important methodological questions about extending transport history beyond its cores, and I suspect it would make for engaging classroom discussions about which sources count in the stories we tell and policies we make. The Nature of the Path could have built more upon the existing literature on African roads and mobility, such as Clapperton Mavhunga, Adeline Masquelier or Jennifer Hart's important work. For instance, Clapperton Mavhunga's insights about spirit-guided mobilities in Zimbabwe as a way to move beyond 'banal', disenchanted mobilities centred in Western ontologies applies to most of the book's chapters and to the author's environmental framing of the road. Given the book draws on rich threads of African historiography in the footnotes, these pioneering works deserved attention. Nevertheless, Filippello's oral evidence and ability to move across historical periods make this an important contribution to African histories of mobility and transport.


We carry out three-dimensional and two-dimensional particle-in-cell simulations of the expansion of a magnetized plasma that initially uniformly fills a half-space and contains a semicylindrical region of heated electrons elongated along the surface of the plasma boundary. This geometry is related, for instance, to ablation of a plane target by a femtosecond laser beam under quasi-cylindrical focusing. We find that a decay of the inhomogeneous plasma–vacuum discontinuity is strongly affected by an external magnetic field parallel to its boundary. We observe various transient phenomena, including an anisotropic scattering of electrons and an accompanying Weibel instability, and reveal various spatial structures of the arising magnetic field and current, including multiple flying-apart filaments of a Z-pinch type and slowly evolving current sheets with different orientations. The magnitude of the self-generated magnetic field can be of the order of, or significantly exceed that of, the external one. Such phenomena are expected in the laser and cosmic plasmas, including the explosive processes in the planetary magnetospheres and stellar coronal arches.


Intangible assets are regarded as the future value drivers of company performance. The increased economic importance requires an intensified analyst and investor awareness of (reported) intangible assets and their financial reporting quality. However, hardly anything is known about the actual importance and influence of different intangible asset classes in different industries. To fill this gap we accomplish a survey among the German Certified Public Accountants (CPAs) concerning intangible assets with a focus on patented technologies in order to determine the influence of intangible assets. We analyze the statements of the German CPAs with regard to intangible assets. Therefore we sent a standardized questionnaire to all 180 offices of the top ten (in terms of revenue) German auditing firms. Our results indicate that intangible assets have gained in importance. According to the German CPAs, the current influence of intangible assets on company performance is on a high level and even will increase during the next few years. The mostly used valuation approach for the fair value measurement of patented technologies is the income approach. Furthermore, the accounting standards leave options for accounting policy – a result which casts doubt on the reliability and quality of financial statements. EFM classification code: 150, 210, 710 JEL-Classification: M40, O34


Exhibition of Berlin Senate Istanbul Scholarship ArtistsCurated by Beral Madra24 March-14 April 2009Gabriele Basch, Susanne Bosch, Thomas Buesch, Erik Goengrich, Natasha Sadr Hadgighian, Isa Melsheimar, Catrin Otto, Nada Sebestyen, Yuan Shun, Roland StratmannSubject that don't count, places that don't matterExcerpts of my archive of ordinary life and by-the-way observations and a number of transcribed excerpts of migration biographieMulti-media installation with 3 sound tracks, 96 films and 400 imagesfrom the Balkans, Germany, Turkey, Thailand, Burma and IrelandThe audio-visual installation presents the transformation of a number of transcribed excerpts of migration biographies and soundscapes from the archive of ordinary life and by-the-way observations by Susanne Bosch.The selected migration biographies reflect the problematic and failed sides of a migratory movement. It also reveals its consequences on a life - like refused asylum statuses, deportation, torture and detainment, broken families, generational and gender conflicts.Every migratory movements stats with the aspiration and expectation of a positive chance of the current situation- and non of these movements is 100%, predictable or controllable.


We describe a prototype for an information system that integrates text and fact retrieval. A query is a set of conditions which relate either to the text or the attribute values of a database object. Conditions may be assigned weights w.r.t. the query as well as to an object. These weights form the basis for a ranking of the database objects w.r.t. the query. As user interface, the system provides a menu-oriented browser.


JN severe cases of scoliosis and kyphosis the capacity of the thorax is greatly diminished. English medical literature is remarkable in the almost complete absence of any reference to the resulting injurious influence on the thoracic viscera and I therefore venture to bring before you four cases of extreme deformity of the thorax resulting in hypertrophy and dilatation of the heart with cardiac insufficiency. Two of these came to autopsy and showed kinking and narrowing of the great vessels, one of the aorta and the other of the pulmonary artery. This feature is so obvious that it is curious that it has escaped notice by so many writers on the subject. Case 1. Male, 50, admitted to the Montreal General Hospital November 29th, 1920, with shortness of breath and cyanosis. He has suffered from marked deformity of the spine from early life as the result of a fall at three years of age. He has always enjoyed good health, earning his livelihood as a beggar up to three months ago, when swelling of the ankles set in. This gradually increased involving the thighs and abdomen and was accompanied by dyspnoea. He became unable to lie down or even to sit and was obliged to sleep leaning over a bed. Present Condition. The patient's head is sunk between the shoulders. There is a marked kyphosis, the dorsal vertebrae forming a large rounded projection, convex from above down and from side to side, measuring 20 c.m. vertically and 25 cm. transversely. Above and laterally this merges gradually with the trunk, but below at the level of the iliac crests it joins the trunk abruptly. Anteriorly there is a corresponding projection on the front of the chest. The depth of the thorax is much increased being 34 cm. from before back with a compensatory lateral compression. The face is much cyanosed, a feature which is much less marked in the hands. There is marked oedema of the legs as high as the hips


Quantitative autoradiography was used to determine changes in GABAB receptor binding in the substantia gelatinosa of the lumbar spinal cord at 4 days and at 6 weeks after a midthoracic spinal transection in rats.


Organized labor has been politically vocal in the United States ever since the movement emerged in the late 1800s. A striking development since the 1970s, however, is its hardening opposition to trade liberalization. Labor leaders have opposed virtually all legislative initiatives since the 1980s to reduce barriers to trade, including the North American Free Trade Agreement, China's entry into the World Trade Organization, presidential Trade Promotion Authority, the Central American Free Trade Agreement, and pending trade agreements with South Korea, Panama, and Colombia.In the past 30 years, labor unions have pushed for higher trade barriers in the form of "domestic content" requirements for autos sold in the United States, import quotas for textiles and steel, and the Gephardt amendments of 1986-87 that would have imposed sanctions on imports from nations that ran large bilateral trade surpluses with the United States (Destler and Balint 1999: 19). More recently, unions have lobbied for higher tariffs, quotas, or outright bans on imported steel, tires made in China, and Mexican-driven trucks on U.S. highways. Labor leaders lobbied hard for the "Buy American" provisions in the $800 billion stimulus package that Congress approved and President Obama signed in early 2009.


This study purposed to develop an E-student worksheet on environmental pollution material to improve the critical thinking skills of junior high school students. E-student worksheet is an electronic-based student worksheet that utilizes the internet in its application. E-student worksheets can create various kinds of content, both visual and audiovisual, to train and assist students in finding concepts through the learning process. The development research method used a 4-D model, but only three stages were carried out: defining, designing, and developing. This research was conducted on seventh-grade students at SMPIT Al Ghozali Jember. The instruments used in this study were validation sheets, learning implementation sheets, critical thinking skills tests, and student response questionnaires. The results of this study indicated that the E-student worksheet had very valid criteria with a value of 94%. The implementation of learning showed very high criteria with a value of 92%. The effectiveness of learning had effective criteria with an average N-gain value of 0.70, and student responses had a good criterion, with a value of 77.3%. It can be concluded that the E-student worksheet on environmental pollution material could improve students' critical thinking skills in science learning in junior high school


The study focuses on the factors influencing the digital transformation (DT) process of telecommunication enterprises in Ho Chi Minh city. The paper concludes on five factors including Leadership, Human Resources, Technology, Workflow and Business Strategy. The research scale is built from 25 independent observed variables, five dependent observed variables and 300 research samples. The linear regression model indicates that the independent factors do influence the dependent factors with a relevance level of 63.9%. The regression model with five factors is proposed through statistical tests and proves its utilization for the study.


We present analyses of two years' lighting data in open office areas, controlled by occupant sensors, time scheduling, or wall switches alone. We compare the energy savings using a before-after analysis of time schedulingand a conservative "moving baseline" analysis of both occupant sensing and time scheduling. Both techniques saved energy effectively when no occupants were present compared with wall switches alone. Time scheduling saved from 0.7 to 6.6 percent or an average of about 5 percent. Occupant sensors in similar areas saved from 9.0 to 14.6 percent, with an average of about 10 percent. False triggering of occupant sensors (by passersby) that would have caused energy waste was avoided by the presence of wall switches that positively turned lights off. Variations in occupant schedules and habits affected overall lighting energy use and the appropriateness of different control types. Little savings were found during the normal 8am to 5pm workday from either technology in large offices, but significant savings occurred after hours and on weekends. Our findings contrast with previous results for private offices in which only a single occupant is present, strengthening the evidence that different types of office space can be controlled appropriately with different types of control systems. However, small percentage savings in open areas can result in larger actual savings due to the larger number of fixtures controlled.


The self-assembly of sexiphenyl-dicarbonitrile molecules on the Ag(111) surface is investigated using low-temperature scanning tunneling microscopy (STM) in ultrahigh vacuum. Several nanoporous networks with varying symmetry and pore size coexist on the surface after submonolayer deposition at room temperature. The different rectangular, rhombic, and kagome shaped phases are commensurate with the Ag(111) substrate and extend over micrometer-sized domains separated by step edges. All phases are chiral and have very similar formation energetics. We attribute this to common construction principles: the approximately flat-lying polyphenyl backbones following high-symmetry directions of the substrate, the epitaxial fit and the nodal motif composed of CN end groups laterally attracted by phenyl hydrogens. Close to saturation coverage, a single dense-packed phase prevails with all molecules aligned parallel within one domain. Our results demonstrate that porous networks of different complexity can evolve by the ...


Analysis of data from clinical trials as TB screening protocols changed shows the value of testing for tuberculosis when treating patients for rheumatoid or psoriatic arthritis or spondyloarthropathies with certolizumab pegol.


The 1500-2500-nm region is of particular interest for remote mineralogical analysis since hydroxyl-bearing minerals, such as clays, alunite, muscovite, and pyrophyllite, which are associated with hydrothermally altered rocks, have diagnostic absorption features in this region. The development and successful flight testing of the Mark II instrument are seen as making possible the acquisition of the necessary high-spectral-resolution data for evaluating this approach to the remote sensing of geological features. Preliminary results of an analysis of data gathered in October 1980 using the Mark II system for selected test sites in Nevada are presented. Even though field and laboratory analyses of the data are only in the initial stages, the results are seen as indicating that this system can be used to detect the most diagnostic spectral features of several economically important minerals.


The use of drama in education can be seen as an alternative to traditional teacher-led, scripted schooling and an answer to the challenges of our current postmodern knowledge culture, which aims at deeper conceptual understanding by preparing students to be more creative and create multimodal knowledge. At the same time the research project "Challenge of the empty space", at Helsinki University's Teacher Education Department, has established that the potential complexity and diversity of creative processes in drama education is a challenge for teachers and as well for Finnish teacher education. In this article we bring together three doctoral studies of teaching drama (Kaasinen, Karjalainen-Väkevä and Lehtonen). They present three different approaches for how a teacher could support students' creativity in a drama class. We suggest, that it might be beneficial for teachers teaching drama to have training in improvisation, to pay attention to the holistic presence and to focus on students' perspectives, agency and ownership in teaching. © 2016 The Authors. Published by Elsevier Ltd. Peer-review under responsibility of Future Academy® Cognitive Trading.


This paper studies determinants of risk premia using a non-parametric term-structure model of the corporate spread. The model, which measures the extra return of defaultable corporate bonds on their government counterparts, involves the rate of inflation, a key macroeconomic variable that is found to explain the spread non-linearly. This study shows that non-linear methods are useful to investigate features of credit risk and that they give better results than their linear counterparts, enabling testing of affine term-structure specifications. The paper also shows how the non-linear model can be used to forecast the future course of the spread.


OBJECTIVE To investigate the characteristics of cervical lymph node metastasis in salivary gland carcinoma.METHODS The clinical data of 815 cases with salivary gland carcinomas in Peking University School and Hospital of Stomatology were reviewed.The influence factors including histopathology type,tumor grade,primary site, tumor size were analyzed.RESULTS The overall rate of cervical lymph node metastasis in salivary gland carcinoma was 11.53%(94/815).The?rst three histopathology types with highest rate were squamous cell carcinoma,clear cell carcinoma,lymphoepithelial carcinoma and salivary duct carcinoma.The histopathology types with lowest rate were acinic cell carcinoma and polymorphous low-grade adenocarcinoma.The rate is significantly higher in submandibualr gland carcinoma than in parotid and sublingual gland(P0.05).The higher rate was noted in the patients with T3 and T4 than T1 and T2 (P0.05).CONCLUSION Histopathology type,tumor size,tumor grade and primary site are the important factors for the cervical lymph node metastasis in salivary gland carcinoma.


Small intestinal submucosa (SIS) had been widely used as a biomaterial without immune rejection responses. SIS sponges prepared by crosslinking with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC). SIS powders dissolved in acetic acid aqueous solution for 48hrs and freeze-dried. EDC solution ( : ethanol = 5 : 95) as a crosslink agent was used in concentration of 100mM. In vitro, rat-BMSCs seeded in SIS sponges and induced the osteogenesis for 28 days. We have characterized the osteogenic potential of rat-BMSCs in SIS sponges by alkaline phosphatase activity(ALP), n assay, SEM and RT-PCR for osteogenic phenotype. In SEM, all morphology of SIS sponges was regular and showed interconnected pore structure. By RT-PCR analysis, we observed type I collagen expression. These results demonstrate osteogenic differentiation of rat-BMSCs. In conclusion, we confirmed that the morphology of surface, cross-section, and side of SIS sponges were highly porous with good interconnections between each pores, which can support the surface of cell growth, proliferation, and differentiation. This result indicates that SIS sponge is useful for osteogenesis of BMSCs.


To overcome the weakness of the wound‐rotor brushless doubly fed machine (BDFM), including the reduction of the harmonic content and improving the utilization of conductor, a low‐harmonic concentric wound‐rotor BDFM is proposed in this paper. First, the design principle and method of winding are illustrated, and the distribution coefficient calculation method that is suitable for all kinds of winding is derived. Next, the calculation of the harmonic magnetomotive force (MMF) is described in detail with a design example. Then a prototype based on the example is fabricated for the experiment. In addition, the selection of the power winding (PW) and control winding (CW) for the stator is illustrated, and the harmonic content characteristics of the rotor winding is analyzed by experiment. The validity of proposed rotor winding structure design is verified by both finite element modeling and prototype experiment. Simulation and experimental results show that the design of proposed rotor winding structure for BDFM has excellent performance. © 2018 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.


Exascale science translates to big data. In the case of the Large Hadron Collider (LHC), the data is not only immense, it is also globally distributed. Fermilab is host to the LHC Compact Muon Solenoid (CMS) experiment's US Tier-1 Center. It must deal with both scaling and wide-area distribution challenges in processing its CMS data. This poster will describe the ongoing network-related R&D activities at Fermilab as a mosaic of efforts that combine to facilitate big data processing and movement.


The Prebisch-Singer Hypothesis states that in structural time series analysis, the terms of trade between primary products and manufacturers have a negative deterministic trend. Many researchers argued that the deterioration in trade is the type of country in which the products are exported, regardless of whether the types of products exported by such countries are primary or manufactured products. This paper employs a development-differentiated model to analyze the correlation between various terms of trade and the export proportion of manufactured products on different economies of development status. In the long run, stable co-integration relations exist between terms of trade and the export proportion of manufactured products for development status. Furthermore, the increased proportion of manufactured products exports is the Granger casualty for the worse terms of trade for several economies of development status. The results demonstrated that changing the terms of trade is significantly influenced by structured changes in the export proportion of manufactured products for the development status of economies.


In the crystal structure of title compound, C9H10N2OS, there are two symmetry-independent molecules, each having an intramolecular N—H⋯O hydrogen bond generating an S(6) ring motif. The benzene rings and the virtually planar acetylthoiurea fragments [r.m.s. deviations = 0.0045 and 0.0341 Å] are oriented at dihedral angles of 50.71 (6) and 62.79 (6)° in the two molecules. In the crystal, N—H⋯S and N—H⋯O hydrogen bonds link molecules via cyclic R 2 2(8) and R 2 2(12) motifs into a one-dimensional polymeric network extending along [101]. The intra- and intermolecular N—H⋯O interactions are part of a three-center hydrogen bond. A C—H⋯S interaction also occurs.


Photoluminescence (PL) properties at room temperature of disordered Ba0.50Sr0.50(Ti0.80Sn0.20)O3 (BST:Sn) thin films were obtained by the polymeric precursor method. X-ray diffraction data and corresponding PL properties have been measured using the 488nm line of an argon ion laser. The PL spectra of the film annealed at 350°C for 21h are stronger than those of the film annealed at 350°C for 28h, indicating a disorganized structure. The energy band gaps of the crystalline and amorphous BST:Sn thin films were 3.35 and 2.25eV, respectively. The doped BST thin films also tend to a cubic structure, resulting from TiO6 deformations.


The influence of weld undercuts and bead flank angles on fatigue strength were experimentally investigated, using fillet welded joints. Non-load-carrying cruciform and tee fillet joints were tested and the life reduction due to undercut was obtained. It was also found that the flank angle had a small influence on the fatigue strength. The life before visible crack initiation and the life of crack growth were evaluated by calculating the elastic stress distribution near the bead toe based on the stress concentration factor. The estimated lives of specimens to failure were compared with test results and it was confirmed that the procedure proposed in this paper gives the life with sufficient accuracy. The influence of undercut depths is quantitavely discussed.


Objective To analyze and evaluate the application value of ultrasound vascular enhancement technology(VET) in fetal pulmonary vein inspection.Methods A total of 368 pregnant women done prenatal ultrasound examination in our hospital from July 2011 to November 2012 were choosed.The fetal pulmonary vein of 368 cases were di vided into group Ⅰ(14-21 weeks,104 cases),group Ⅱ(22-29 weeks,213 cases) and group Ⅲ(30-37 weeks,51 cases) according to gestational age.All pregnant women were done four kinds of pulmonary vein inspection,including twodimensional echocardiogram(2-DE),color doppler flow imaging(CDFI) and color doppler energy(CDE) and VET.The results of four kinds of inspection methods were compared and analyzed,and the application result of four kinds of methods in different gestational age groups were compared.Results In 104 cases of group Ⅰ,the number or proportion of patients having the display in 2-DE,CDFI,CDE and VET were 17 cases(16.3%),35 cases(33.7%),46 cases(44.2%) and 87 cases(83.7%) respectively;In 213 cases of group Ⅱ,the number or proportion were 46 cases(21.6%),99 cases(45.8%),112 cases(52.6%) and 197 cases(92.5%) respectively;In 51 cases of group Ⅲ,the number or proportion were 16 cases(31.4%),31 cases(60.1%),30 cases(58.8%) and 32 cases(62.7%) respectively.The display rate of VET was the highest among four kinds of inspection methods,and the display rate of VET in group II increased markedly,the difference was statistically significant(P 0.05).Conclusion VET has higher display rate in fetal pulmonary vein inspection,and the results show that the best time to inspect fetal pulmonary vein is second trimester.VET can provide some reliable basis for clinical fetal pulmonary vein inspection.


A RECENT article in SPECULUM suggested that Chaucer's Pardoner may best be understood in terms of Augustinian theology.' It is po,ssible that the principles discussed there may be profitably elaborated. The intent of this paper is to indicate that the tradition of which St Augustine was perhaps the most influential expositor provides more than a general climate of idea: specifically, that Scriptural imagery, utilized by Chaucer in the portrait and tale of the Pardoner, serves to illuminate quite precisely the nature of the man and the "moralite" of his sermon. We are learning that the mediaeval author sought to build up the surface or cortex of his work in such a way as to indicate some particular nucleus, or inner meaning.2 For this purpose he had at his command two main sources of material: the Book of Nature or God's Creation the data of sense perception, and another Book the Bible which offered the unperceived data of revelation. Both "Books" provided the opportunity to achieve by study and interpretation a better knowledge of their Author. The Old Testament foreshadowed the "New Law" of charity under a series of types or figures, and was consequently to be reinterpreted in this light. Both the Bible and the Book of Nature provided a type of surface reality a series of signs which, if properly understood, reflected the will and the law of God. The compaignye created by Geoffrey Chaucer for the most famous fourteenthcentury literary pilgrimage has been almost microscopically examined by the modern scholar in the effort to arrive at the most satisfactory understanding possible of the text of the Canterbury Tales. The characters are so firmly conceived that attempts have been made to identify the actual prototypes whom Chaucer may himself have known; and considerable study has been devoted to the various mediaeval sciences which provided details of psychological or physiognomical characteristics. It is surprising, however, to find scholarly effor-t directed so intensively upon what the mediaeval author called the cortex of his work, without an equally persistent effort to discover what nucleus might lie beneath. What we now call realism was of itself only a point of departure in a


The purpose of this study is to analyze the long-term and short-term effects of paddy field area, rice prices and rainfall on rice production in Pati Regency. This study uses the ARDL analysis method. Secondary data obtained from the Central Statistics Agency 1990-2019. From the calculation using ARDL, it was found that the rice price and rainfall variables had a positive and significant effect on rice production, both in the long term and in the short term. Meanwhile, the variable area of ??land does not significantly affect the yield of rice production, both in the long and short term.
Keywords: Production, Land Area, Price, Rainfall


In West Africa especially in Nigeria uses of Artocarpus altilis fruit (breadfruit) have been used traditionally in the management of diabetes mellitus and its complications. This study was designed to investigate the effect of the Artocarpus altilis fruit (breadfruit) based-diet on fasting blood glucose level, haematological parameters and serum lipid profiles in alloxaninduced diabetic rats. In this study, the in vitro antioxidant parameters were determined on aqueous extract of the Artocarpus altilis fruit, while in the in vivo study thirty-two albino rats (Rattus norvegicus) were used and grouped into four: control, diabetic untreated rats, diabetic rats administered with metformin daily and diabetic rats fed with Artocarpus altilis fruit baseddiet. All rats except those in control group were induced intraperitonially with a single dose of 150 mg/kg of alloxan. The aqueous extract of the Artocarpus altilis fruit contained total phenol, total flavonoid, DPPH, FRAP and Fe2+ chelation. Administration of alloxan significantly increased (p<0.05) fasting blood glucose, LDL and VLDL with significant reduction (p<0.05) in all the haematological parameters and HDL. The feeding of the diabetic rats with Artocarpus altilis fruit based-diet significantly ameliorated all these effects to normal. Therefore, the results suggest that consumption of Artocarpus altilis fruit based-diet by diabetic rats ameliorated antihyperanaemic and antihyperlipidemic complications.


Abstract:In his Summa Sacre Magice, Berengarius Ganellus had a special place for Hebrew, which he described as superior to Latin, Arabic, and Greek. Although Ganellus was not fluent in Hebrew, and there is no evidence that he read Hebrew sources, he surely draws upon Jewish sources. This article examines how Ganellus used some Jewish texts in his summa, especially the text Shi'ur Qomah. Shi'ur Qomah is a text known from at least the tenth century, in which a lengthy description of the body of God, its organs, and their divine names. As will be shown, Ganellus's unique use of Sh'iur Qomah underlines his eclectic approach and creativity.


In 1969, the Business School of Georgia State University (GSU) initiated a new program of study leading to the degree Master of Business Information Systems (MBIS). The program has gone through a series of refinements in order to better fulfill its primary objective of developing business systems designers and information analysts who would be responsible for designing, implementing and evaluating computer based information systems in organizations. The lack of a model that may be used for constructing a suitable curriculum led the author to the development of a goal oriented approach for designing curricula. It provides a systematic way of designing a curriculum for an evolving multidimensional field like computer science. This paper describes the factors that led to the development of this approach and its practical advantages.


Objective To formulate protective measure,reduce expose risk of danger medicine. Methods Through literature,search according of medical member health destructive of vocational contact for danger medicine expose. It appeal government department and hospital lead,strengthen management of danger medicine expose,install sciencecom-pounding place,construct the system of instruction and training,take utility protective device,and secure medical health. Results Internal,the many hospital have been contructsd vein medicine collocation center with trainingprofessional staff disposed dangerous medicine to decrease chance of dangerous medicine expose. Conclusion My popliteal medical member cytotoxic drug protection are not enouge and precau-tion consciousness are frail. It should pay more attention formulate and implement effectual protective device to secure the occupation of medical member.


In this study, capitalization rates based on owner operated fields that are irrigated land was determined in Pazar district of Tokat province. The data used in the study were obtained from 79 farms by survey. The data were collected through a survey for the years of 2008-2009. 85,63 percent of the farms in the survey were owner operated. The whole field land was cultivated. Usable capitalization rate of owner operated and irrigated field land were 4,38 percent in the research area. 1. Giris


Sequential data mining involves analysis of sequential patterns of varying length. Sequential pattern analysis is important for pattern discovery from sequences of discrete symbols as in bioinformatics and text analysis, and from sequences or sets of continuous valued feature vectors as in processing of audio, speech, music, image, and video data. Pattern analysis techniques using kernel methods have been explored for static patterns as well as sequential patterns. The main issue in sequential pattern analysis using kernel methods is the design of a suitable kernel for sequential patterns of varying length. Kernel functions designed for sequential patterns are known as dynamic kernels. In this chapter, we present a brief description of kernel methods for pattern classification and clustering. Then we describe dynamic kernels for sequences of continuous feature vectors. We then present a review of approaches to sequential pattern classification and clustering using dynamic kernels.


A COMPARATIVELY simple and convenient method is available for solving the division of current in the various sections of an electrical network and obtaining the voltages at the different load points. The method consists essentially of the application of Kirchoff's laws to the solution of a network, the departure from the usual procedure being that instead of solving a number of simultaneous equations, the problem is handled in steps by the superposition of currents. The idea of a circulatory current is introduced when any change in the system is made by a closure between two points in the existing system.


The prevalence of bovine tuberculosis among cattle population slaughtered in Lafenwa, Abeokuta, abattoir was determined and the pathology associated with the disease was described in the present study. The ages, sexes and total number of cattle slaughtered and examined was recorded over a period of six months (October, 2015 to March, 2016), out of which suspected cases of tuberculosis were sorted out. The prevalence of bovine tuberculosis was calculated as percentage of occurrence as overall, age and sex-specific; and gross lesions were described. Tissue samples of the lungs, liver, Intestine, lymph nodes were collected from the affected animals in two parts; one for Ziehl Nelson staining and the other was fixed in 10% buffered formalin for histopathology. Among the 25,875 cattle examined, an overall prevalence of 8.72% was recorded. Monthly prevalence varied from 5.28% in October to 11.33% in December, 2015. Sex-specific prevalence was higher in females (89.94%) than in males (1.0.06%). Gross lesions observed were severe and diffused necrosis in the lung parenchyma with marked creamy caseous yellowish nodules of variables sizes in 100% of the cases. In some cases, similar lesions were observed in the liver, intestine, heart, kidneys and lymph node. Histopathological lesions in the lung and extra-pulmonary organs were severe necrosis with calcified centers; and there were granulomatous inflammation. Ziehl Neelsen stain demonstrated reddish bacilli suggestive of Mycobacterium organisms. There was an increase in the cases of tuberculosis among cattle population slaughtered in Lafenwa abattoir when compared with those reported in previous studies.


A theoretical approach to the absorption properties of molecules adsorbed on powdered solids is presented. Thus expressions for the reflectance and transmittance of the surface of coated particles with sizes large compared with the wavelength of light are derived. Taking into account the scattering of light in disperse adsorbent–adsorbate systems, these quantities are averaged over the direction of incidence and the polarization angle of the light. An absorption cross-section of adsorbed molecules analogous to the molar extinction coefficient of dissolved molecules is defined and its frequency dependence is discussed.


We may properly ask what was the purpose of the restricting side-lines. They were probably a practical safety measure, ensuring that the throwing should be done from a point near the central axis of the stadium. Gardiner suggests that the throwing line may well have been the same as the starting-line for runners. Had the throwers been allowed to throw from any point they pleased behind that line, a discus thrown from a spot near the side of the stadium, if it swerved only a little 'off the beam' towards that side, would have landed in the spectators' seats. A central Balbis reduced this risk considerably. Even in sport the discus and javelin were dangerous missiles, as we are reminded by the stories of Hyacinthus and Acrisius and by the second Tetralogy of Antiphon.


Be it the era of current Industry 3.0 (3D printing) or the era of Industry 4.0
(customised production) in the future, as far as globalisation is concerned,
based on combinations of automation & information and intelligence, the application
of Big Data, new Cloud Computing technologies, Internet of Things
or new internet industry and AI will usher in a huge revolution to human
beings, which will consequently rock foundations of modern economy, politics,
social sciences, management and accounting, etc. and even bring about
fundamentally changes and development, and hence an era for technology
industry going novelty, i.e. customised production. Commercial re-group and
the drastic society change will influence not only the overall ecological pattern
around the world but also human beings' value system, knowledge system
and life style. Many seeming probabilities today will become impossible
while the impossible at the moment will go real in the future. Under such
complicated, constantly changing and rapidly developing circumstance, only
when the passive situation of tabulating and interpreting is completely changed,
can national economy's smooth operation be directed by the objective law of
coordinated development, and thus, to achieve the utmost economic efficiency.
The scientific foundation of the real-time input-output tabulation method and
AI is rightly designed on the basis of the above dreaming realisation. This
thesis will take the real-time analysis of the optimal input-output planning
model and a timely analysis of input-output statistical model as an example to
illustrate how to realise the good wish.


Objective: To study the physiological significance of the lumbar intervertebral foramina ligaments in infants. Methods: The lumbar intervertebral foramina ligaments were injected and observed on 11 cases of the full-term infant cadavers. The related data were measured with vernier caliper. Results: The width, thickness and length of the inferior transforaminal ligaments in L1, L2 and L3 were: L1: 1.4±0.4 mm, 0.4±0.2 mm, 2.8±0.5 mm; L2: 1.3±0.4 mm, 0.4±0.2 mm, 2.8±0.5 mm; L3: 1.6±0.1 mm, 0.4±0.1 mm, 2.8±0.9 mm respectively. The width, thickness and length of the inferior corporotransverse ligaments in L3,L4 and L5 were:L3: 2.1±0.4 mm, 0.6±0.1 mm, 4.5±1.2 mm; L4: 2.0±1.2 mm, 0.4±0.2 mm, 5.7±0.8 mm; L5: 2.4±0.8 mm, 0.4±0.2 mm, 5.0±1.0 mm respectively. Conclusions: The lumbar intervertebral foramina ligaments are the normal components of the intervertebral foramen in infants.


Overall, sixty-seven patients living in different ecological regions were examined to study effects of ecological factors on the catecholamine concentration in biological fluids in patients with chronic posttraumatic osteomyelitis (CPO). The data obtained showed that CPO causes abnormalities of catecholamine metabolism, which get even more aggravated under the influence of an adverse ecological factor, an abnormal radiation impact in particular, this being confirmed by analysis of findings in those patients residing in different ecological regions.


A 2-year-old boy presented with gait imbalance and strabismus over the last two weeks. Computed tomography revealed a large heterogeneous midline posterior fossa mass with calcifications. Magnetic resonance imaging demonstrated a mass within the 4 ventricle, extending through foramen of Luschka into the left cerebellopontine angle without any infiltration of the vermis.The patient was operated. Histological examination revealed the presence of a malignant highly cellular neoplasm with morphological heterogeneity, composed mainly of small round cells with a limited cytoplasmic rim and a brisk mitotic activity. Interestingly, areas of tumor cells with eosinophilic cytoplasm and low mitotic activity were observed.There was expression of Synaptophysin in the small round cell areas of the neoplasm. The cells with low mitotic activity were negative for synaptophysin but positive for desmin, myogenin /Myf-4 and MyoD1. There was no expression of keratin, EMA and GFAP. INI-1 nuclear expression was retained in all neoplastic cells. A diagnosis of medulloblastoma with rhabdomyoblastic differentiation was established. Postoperatively the patient received high dose chemotherapy and one year later no tumor recurrence was noted. Correspondence 472 Brain Pathology 21 (2011) 469–472 © 2011 The Authors; Brain Pathology © 2011 International Society of Neuropathology


ABSTRACT To the Editor: —In The Journal, October 25, Weidman under this title gives credit to Wile and his co-workers for being the pioneers in the application of the biologic fact that the administration of chlorides hastens the elimination of bromides.Permit me to draw your attention to the fact that prior to or at least simultaneously with Wile, I recommended the salt treatment for bromism. At the annual meeting of the American Dermatological Association in Washington in 1922 I stated (Arch. Dermat. & Syph. 6:559 [Nov.] 1922) in a discussion of a paper on drug eruptions: "The facts mentioned by Dr. Wile, that chlorides replace the bromides in the body, has induced me for many years to give patients with bromide eruption either a diet rich in salt or to administer calcium chloride by mouth." Dr. Wile in closing the discussion on his paper on bromide exanthems answered (p.


An investigation of the mercury photosensitized decomposition of ethane has been made, the products of the reaction being analyzed by low temperature fractional distillation. It is found that by improved trapping methods it is possible to remove butane from the system as formed, and thus the formation of secondary products is entirely inhibited. Under these circumstances the products of the reaction consist exclusively of methane, propane, and butane, the hydrogen and higher hydrocarbons found in previous investigations being secondary products of the propane and butane decompositions. The quantum yield (in terms of ethane disappearing) is approximately 0.2. The suggested mechanism of the reaction is: C2H6+Hg(23P1)=2CH3+Hg(11S0)CH3+C2H6=CH4+C2H52CH3=C2H62C2H5=C4H10CH3+C2H5=C3H8.


The effect of intraperitoneal administration of sodium glutamate at the dose of 1g/kg of body weight on the structures of the dorsal root ganglia in the lumbar region (L1-L4) of neonatal Wistar rats was investigated. After single doses and five consecutive doses of sodium glutamate, identical changes in the form of cytoplasma vacuolizations in both ganglionic neurons and the accompanying gliat satellite cells were observed. Through electron microscopic examination, vaculoes were identified as swollen mitochondria and without mitochondrial cristae. These results indicate that intraperitoneally administered sodium glutamate may have caused the fenestrated vascular endothelium of vessels and brought about a cytotoxic influence on the ganglionic neurons and glial satellite cells.


To determine whether call frequency, mode timing, time‐varying frequency cues, or spectral (timbral) characteristics were important to call recognition in the Emperor Penguin, a phase vocoder was used to vary timing and frequency parameters of natural display calls independently. The syntheses were of five types: natural display calls; noise bursts with the correct timing, but without either the harmonic spectrum or frequency modulation of the natural call; modes with the correct spectral characteristics and timing, but lacking frequency modulation; calls with timing lengthened or shortened without altering spectral characteristics; and ''hybrid'' calls with the correct frequency spectrum and modulation of one individual, but the mode timing of another. Syntheses were based on natural calls of familiar and unfamiliar individuals. They were played to 52 emperors in an artificial habitat at Sea World of California. Since Emperors respond preferentially to the calls of strange individuals, differences in res...


The tyranny of psychotherapy psychoanalysis, social role and testability problems of methodology in studies of psychotherapy the outcome problem in psychotherapy the myth of therapist expertise what goes wrong in the care and treatment of the mentally ill does psychotherapy need a soul? psychotherapy and political evasions concluding remarks.


The snake bites are in the Sri Lankan population at risk; however, there should be targeted programs to educate people on these aspects. Studying the awareness and perceptions related to such issues of risk groups is important in designing community based interventional programs on snakebite towards combating the global burden of snakebite. Such information is lacking on the farming community of Sri Lanka. Therefore this mini review will highlight the importance of the snake bites awareness in Sri Lanka. Snake bites are well known medical emergencies in many parts of the world, especially in rural areas. Agricultural works and children are the most effected victims on snake bites in Sri Lanka. Sri Lanka is considered as a country with highest morbidity rates of snakebites in the whole world. It is highest in North Central Province, compared to any other areas in Sri Lanka, due to large faming community. However, the true scale of mortality and acute and chronic morbidity from snake-bite remains uncertain because of inadequate reporting in almost every part of the region. The incidence of snake bite mortality is particular high in this country and according to national statistics; the annual snake bite incidence in Sri Lanka ranges 35000-40000 during past 10 years.


Abstract : The Epoxy Lamina (EL) concept is introduced to explain overall stiffness reduction in Z-pin reinforced composite laminates, as reported by Zhang et al., for a typical 2%-vol fibre content. The concept is applied to a quasi-isotropic laminate, whereby both the softening and strengthening effects are separated out and quantified, based upon experimental data. This study is accompanied by a FEM-based micromechanical addressing of the composite. A set of fibre arrangements is considered so as to match reported laminate properties, looking for a consistent layout to include the Z-pins effect. These treatments fall within linear elastic behaviour, and are essential to a sound study of the upcoming inelastic regime.


Introduction. In June–July 2016, a barrage of extreme rainfall hit the middle and lower reaches of Yangtze River in eastern China, which caused severe urban inundations in large cities such as Wuhan and Nanjing, and resulted in direct economic loss of 70 billion RMB (about $10 billion U.S. dollars). Similar to the 1998 Yangtze River extreme rainfall, the 2016 extreme rainfall coincided with the decaying phase of 2015/16 super El Niño through Pacific–East Asian teleconnection which enhanced the west Pacific subtropical high (WPSH) and weakened the East Asia summer monsoon (EASM), resulting in an anomalously anticyclonic circulation pattern over the northwestern Pacific that brought lots of atmospheric moisture from the Pacific to the Yangtze River (Wang et al. 2000; Yuan et al. 2017). A possible mechanism for the lag-impact of El Niño/Southern Oscillation (ENSO) on East Asia summer climate is the Indo–western Pacific Ocean capacitor (IPOC), where the North Indian Ocean warming after El Niño plays an important role (Xie et al. 2016). The spatial distribution of the 2016 extreme rainfall, however, is different from that in 1998 with a northward shift of the ENSOforced teleconnection (Figs. 22.1e,f), which raises the question of whether the climate change and El Niño increase the likelihood of Yangtze River extreme rainfall. This paper will examine the 2016 extreme rainfall in a historical context, and investigate the effects of anthropogenic climate change and natural climate variability (e.g., ENSO) on the likelihood of the extreme rainfall.


When this has been a lot of developers or developers of housing as executor in the
fieldcoordinator needs to accompanied by the development of computer technology to meet
the housing needs of the consumer buyer, which generally residential consumers as a buyer
always has the considerations or factors before making a decision. But manyhousing
information is not known by the purchaser or consumer, because that is necessary to find
alternative media more interesting information. The method used in the manufacture of this
java based application is the RUP (Rational Unifed Process) that divides the stages of
software into four phases starting from the Inception Phase, Elaboration Phase,Construction
Phase, and Phase Transition. The results of java-based application design is expected to be an
alternative for users who need a home buyer or home information they want.


Temperature sensors for application in the process industry are typically mounted in a thermowell. These tubular fittings penetrate the surface of e.g. a pipe and allow to insert a temperature sensing element into the process medium. Although this invasive sensing is state-of-the-art, thermowells suffer from significant drawbacks: Any pipe penetration is a potential cause for leakage and the thermowell itself is prone to corrosion, abrasion and bending stress. Avoiding the thermowell by measuring temperature on the surface of the process container was so far not considered a widespread alternative to invasive sensing. The temperature of the surface is generally not considered representative for the temperature of the process medium. A surface sensor is strongly exposed to the ambient condition and, furthermore, the calibration of such a surface sensor is challenging. In this paper we demonstrate how to overcome these limitations by an optimized thermo-mechanical design and enhanced model-based sensing. In combination with energy autonomous operation and wireless communication our novel non-invasive sensor offers a remarkable flexibility enabling scenarios discussed within the context of internet of things (IoT).


The present invention discloses a structure and method for manufacturing the ESD protection circuit of an SOI, the structure comprising a substrate and a SOI gated diode ESD protection device is located on the SOI substrate, wherein the gated diode ESD protection device comprising: a positive electrode, a negative electrode, a channel, a gate dielectric layer and a gate; the positive and negative electrodes are located at both ends of the channel, the gate dielectric layer and gate electrode are sequentially positioned over the channel; the channel region and an N-type composed of P-type region and the N-type region of the PN junction structure of longitudinal and P-type region is formed. The present invention implantation Lu longitudinal large area PN junction for ESD design, greatly increasing the PN junction area, to improve the large current discharge capability, to achieve integration with bulk silicon ESD circuit comparable improved SOI circuit ESD by ion stick of. Low cost manufacturing process which is fully compatible with conventional SOI circuits.