Ipsen entered into a strategic partnership with Inspiration Biopharmaceuticals to provide funding to develop the latter's haemophilia products. Ipsen will also grant Inspiration an exclusive worldwide sublicense to its own recombinant porcine Factor VIII product, OBI-1.


We propose an effective model to describe the $A_{2g}$ signal in Raman scattering experiments in the URu$_{2}$Si$_{2}$ compound. We follow the scheme proposed earlier by Khveshchenko and Wiegmann [Phys. Rev. Lett. 73, 500 (1994)] to calculate the $A_{2g}$ scattering vertex. We extract the imaginary part of a two-point current-current correlation function and compare it directly with the Raman response. We obtain an inelastic peak at $A_{2g}$ channel owing to the interplay between a local staggered ordering and a possible quantum spin liquid behavior. Our results offer an explanation for the electronic Raman scattering experiments at the hidden order phase in URu$_{2}$Si$_{2}$ compound [Phys. Rev. Lett. 113, 266405 (2014)].


This study was carried out to understand the particle-particle interaction in multiphase flows. We used light polstyrol particles (density 0.05 g/cm3) which were colored to detect the particles at higher void fractions. To investigate the influence of the shape on the particle interaction spherical as well as ellipsoidal particles were used. The polystyrol particles behave similar as air bubbles in water because of their relative low density. This was documented by several experiments of the motion and wake structure with single rising bubbles and particles [1]. The particles were studied in a water tank in counter-flow. A stereoscopic three-dimensional PTV systems was built up to record the particle motion. By using different concentration of water/glycerine mixture we are able to simulate different Reynolds-numbers. The results demonstrates that the shape of the particles plays a dominant role on the interaction, see the particle pair distribution shown in Fig. 1. In case of the spherical particles, most of the particle pairs are horizontally aligned which is a clear trend of bubble pairing. This agrees with the observations made by Fortes et al. (1987). In contrast, the prolate spheroids show a different distribution which can only be attributed to the different shape. It is likely, that the additional degree of freedom of the prolate spheroids to tilt or to align with the flow is the main reason which has also great influence on the drag and lift-forces.Copyright © 2002 by ASME


Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) quickly became a major epidemic threat in the whole China. We analysed SARS-Cov-2 infected cases from Tibetan Autonomous Prefecture, and noted divergent characteristics of these Tibetans infected cases compared to Han Chinese, characterizing by a considerable proportion of asymptomatic carriers (21.7%), and few symptomatic patients with initial symptom of fever (7.7%). Here, we did a descriptive study on clinical characteristics of 18 asymptomatic individuals with SARS-CoV-2 infection. The median age of these asymptomatic carriers was 31 years and one third of them were students, aged under 20 years. Notably, some of asymptomatic carriers had recognizable changes in radiological and laboratory indexes. Our finding indicates a potentially big number of SARS-CoV-2 asymptomatic carriers in prevalent area, highlighting a necessity of screening individuals with close contact of infected patients, for a better control on the spread of SARS-CoV-2 infection.


Background There is a known association between elevated serum uric acid (SUA) and incident hypertension (HTN) especially in Black males but the data is scarce in Africa. Objectives We aimed at evaluating the relationship between the severity of HTN and SUA in a population of newly diagnosed and untreated HTN Methods A cross sectional study conducted in Douala from January to December 2012. Participants were newly diagnosed untreated hypertensives recruited during a community based screening in an urban area of Cameroon. Patients with a history of gout were excluded. HTN was diagnosed after three consecutive blood pressure readings on 3 separate occasions following the screening exercise. SUA assays were performed on fasting blood samples. Results Of the 839 participants included, 412 (49%) were males. Mean age was 50 years (range 29-81); mean BMI was 26.8; Mean SUA was 60.47±16.53 mg/l, with 65.1±16.54 mg/l (29- 112) in males and 55.98±15.26 mg/l (26- 108) in females 267 (31.8%) participants had elevated SUA levels. Among the participants with elevated SUA, 51% were males, 12.7% had a family history of HTN, 5.7% were smokers, and 8.2% had a fasting plasma glucose level ≥1.26g/L. 202 (75.6%) patients had stage 2 HTN and SUA levels were significantly higher compared to the other stages of HTN (p=0.001 Conclusions Stage 2 hypertension was strongly associated with elevated SUA levels in newly diagnosed and untreated hypertensives of indigenous black Africans. More studies are required to characterize this association. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5596


Several trade theories put some premium on the development of international trade between countries with comparative advantages in industries where productive resources are in abundance and in intensive use as suggested in the popular Hecksher-Ohlin theory but very few studies have investigated the relevance of intra country trade in respective trade blocs as a development tool for less developed and developing countries. In the light of the aforementioned, the study evaluate intra-Africa trade in the sub Saharan African region. The study considered a cursory study of the internal socio-economic and political dynamics of Sub Saharan African countries excluding South Africa, considering that South Africa singlehandedly accounts for more than 33% of the intra African trade in the Sub-Sahara African region, time series data on trade flows spanning between 1995 and 2011 were considered, the data were sourced from the United Nations Conference on Trade and Development (UNCTAD, 2012) and on the basis of this a comparative analysis of the revealed comparative advantages of the country groupings that makes up the Sub Saharan African region is carried out to ascertain the current position of intra country trade in the regional trade blocs in the Sub Saharan African region. The findings revealed that there is need for African countries to look inwards with the long term goal of mutually providing the needed impetus to drive growth and development via intra-African trade. Such catalyst for efficient intra-African trade such as security of lives and property, development of relevant 'take off' infrastructure and social capital, provision of deep financial systems and efficient regulatory frameworks, sound internal macroeconomic policies and the reduction in such social milieu as corruption, vice and underground economic activities should be pursued with the long term goal of encouraging intra-country trade within a given trade bloc. This study concludes that Africa cannot survive in isolation vis-a-vis the rest of the world. It therefore recommends that driving regional trade in Africa should be complementary to improving trade relations with the rest of the world particularly, those regions that seems to be at advantage trading position with African countries.


The Islamic religious education was important things for all the students especially for elementary level. It's be expected from the Islamic science and knowledge to guidance in the next life. Even more to the students with autism syndrome, it will be more important for them. They have many difficullities in their communications, social interactions dan behaviours, so make the problem in accepting the kwonledge. Bassed on researches dan technologies, many kind of intervention will be solution for this problem. And social story is one of the various solution in it. This study has purpose to describe the planning, implementation and evaluation of Islamic religious education learning with the social story method to increase the positive behavior of autistic students. at Cordova Homeschooling, and to determine the positive behavior of autistic students that could be improved. It's used descriptive qualitative method with a case study approach. The techniques for collecting data is interview, observation, and documentation, that analyzed by condensing, displaying, and drawing conclusions, and checked by triangulation for validity. The result for this study is that planning of this method is includes purposes, materials, strategies, and learning media. The implementation is uses the social story method with image media and supported by verbal explanations, repetition, prompting, reinforcement, and tests. The evaluation is uses learning program evaluation routinely. The positive behaviors can be improved in cognitive aspect and practice one.


The metabolism of benz(a)anthracene (BA), 7,12‐di‐methylbenz(a)anthracene (DMBA) and benzo(a)pyrene (BP) by human mammary epithelial cell aggregates in culture has been investigated using non‐neoplastic tissues obtained from eight patients undergoing reduction mammoplasty. All three hydrocarbons were metabolized to water‐soluble and organic solvent‐soluble products and the latter included both K‐region and non‐K‐region dihydrodiols. The major dihydrodiols detected as metabolites of the parent hydrocarbons were the 8,9‐dihydrodiols of BA and DMBA and the 9,10‐dihydrodiol of BP. The 1,2‐dihydrodiols of BA and DMBA and the 11,12‐dihydrodiol of BP were not detected. The hydrocarbons also became bound to the proteins and DNA of the epithelial cells but there were wide differences in the extents of binding occurring with the different hydrocarbons and in the extents of metabolism and binding occurring with tissue preparations from different patients. Some of the hydrocarbon‐deoxyribonucleoside adducts formed from DMBA and BP appeared to have arisen through reactions of »bay‐region« diol‐epoxides with DNA, but only very low levels of reaction with DNA, but only very low levels of reaction with DNA were detected in tissue preparations treated with BA.


According to the flow of the digital reference service,this paper advances that the quality control of digital reference service should be made from four aspects of the technology,librarians,users and management.


The purpose of this research is to identification the influenc of variables in brand equity to customer satisfaction. Customer satisfaction s needed in business and it is so important if thr company want to get profit from the product that they produce. Most of the business fashion and beverage are from aboard. If the company want to success, so the company must able to satisfy the customer needs. Brand equity is set of asset about the brand that increase or decrease the value of brand to the company or to customer. in brand The purpose of this research is to identification brand awareness and perceived quality of variables in brand equity, brand image and price as dependent and customer satisfaction as independen variables. In this research, data collecting is done by giving out questionnairs to 82 respondents in Surabaya. Sample collecting technique that is used is non probability sampling with convenience sampling as the sampling method. And in this research the four variables significantly impact customer satisfaction. And the variables that most impact of the customer satisfaction.

Keywords: Brand Awareness, Perception Of Quality, Price, Brand Image, Customer Satisfaction


A group training course utilizing videotaped material and discussion proved to be as effective as traditional methods in teaching medical students to obtain information from co‐operative psychiatric patients.


Abstract Copper doped polymer shells can provide a very useful diagnostic for fast ignition experiments currently being performed at various laboratories around the world. The low concentration copper dopant acts as an efficient x-ray source providing information on the physics of fast ignition. We have developed copper doped glow discharge (GDP) coatings suitable for such purposes. Copper acetylacetonate (CuAcAC), a solid at room temperature, was used in a heated jacket as the dopant source. We used this technique to fabricate thin (~5-7 μm) GDP shells doped with ~1 at % copper through the depolymerizable mandrel process for fast ignition experiments. The details of the experimental set up and the range and limitations of the technique are discussed.


ABSTRACT Despite growing evidence for the potential risk of brain injury due to repetitive, subconcussive head impacts in youth football, a longitudinal assessment of head impact exposure (HIE) in this population is lacking. Purpose This study examined HIE of middle school football players over multiple seasons. Methods Head impact exposure was evaluated in 103 football players (11–14 yr) who participated in a community-based youth tackle football program, up to 2 yr, with the same coaching staff over eight consecutive seasons (2012–2019). Head impact exposure was assessed using the Head Impact Telemetry System. Median of individual mean head impacts per session (HIPS) and median of individual 50th and 95th percentile head impact magnitudes were compared across seasons. Results There were 33,519 head impacts measured throughout the study. Median HIPS for all sessions decreased every year, with a significant reduction from 2012 to 2019 (11.1 vs 2.3 HIPS; P < 0.05). Median game HIPS were significantly reduced in 2019 compared with 2012–14 (5.00 vs 16.30–17.75 HIPS; P < 0.05). Median practice HIPS were reduced by 81.3%, whereas median game HIPS were reduced by 69.3%. Median 50th and 95th percentile linear and rotational acceleration were lower in 2019 compared with some earlier years but remained unchanged during games. Conclusions Head impacts incurred by youth football players decreased substantially over eight seasons, with players in the final year sustaining approximately one fifth the HIPS as players experienced during the first year. The most prominent decline occurred in practices, although players also had much fewer head impacts in games. These results suggest that coaches' and/or players' behavior can be modified to greatly reduce the head impact burden in youth football.


Despite our extensive understanding on the Internet business and widely understood first-mover advantage. it is not clearly answered yet whether an internet firm can enjoy the first-mover advantage in the new environment of the Internet. This is mainly because the Internet marketplace itself has a complex combination of various business models, ranging from a simple channel-extension to a whole new business model. Based on new theoretical development on the first-mover advantage, we empirically test whether being an early mover in the Internet environment materially affects firm performance, using clickstream data from Korea where broadband Internet installation is ranked as top among OECD countries. Our results show the effectiveness of first-mover advantage on the web does not exist, regardless of its business model and competitive environment. This result expands our understandings on the e-business, not to mention of the real feature of first-mover advantage.


Summary The inner shock structure of a sonic boom propagating through the atmosphere is controlled by dispersion and dissipation associated with the relaxation modes of oxygen and nitrogen. Using asymptotic and numeric methods, the shock structure is analysed and the change in shock thickness along the ray path is determined. Accurate predictions of shock overpressure and shock rise-time are important in determining the subjective annoyance of sonic booms produced by supersonic aircraft. To assess the problems associated with sonic booms at ground level, the propagation of disturbances over long ranges must be investigated for a realistic atmosphere. In particular the effect of atmospheric parameters on the shock amplitude and shock thickness/rise-time must be predicted accurately. For a supersonic body, a disturbance is generated in the form of a Mach cone. Close to the body, the exact form of the disturbance depends on the detailed geometry of the body, but over a number of wavelengths, the effect of the quadratic nonlinearity is to form a N-wave. Predictions of shock overpressure and shock rise-time are important in determining the subjective annoyance of sonic booms at the ground. Hence, the propagation of disturbances over long ranges must be investigated for a realistic atmosphere. In particular the effect of atmospheric parameters on the shock amplitude and shock thickness/rise-time must be predicted accurately. The evolution of the disturbance along ray paths normal to the shock front is governed by the combined effects of geometrical spreading, finite-amplitude effects, stratification and diffusion/dispersion due to molecular processes. For acoustic propagation through the atmosphere, thermoviscous diffusion does not fully describe the complex molecular processes present and relaxation due to internal vibration energies of polyatomic molecules must be included. Each relaxation mode is characterised by a relaxation time and the difference between low- and high-frequency linear sound speeds. Ignoring the effect of stratification, the governing equation for the perturbation pressure, suitably non-dimensionalised, is @p @T p @p @X +j p 2T = @ 2 p


Cranberry (Vaccinium macrocarpon) is a very useful drug in Unani system of medicine and Ayruvedic system of medicine. Research has suggested cranberry may be effective against UTIs (urinary tract infection) because it prevents Escherischia coli, the bacteria that cause most urinary tract infections, from attaching to the walls of the bladder. It only grows in open, sunny, wet areas in the colder regions of the Northern Hemisphere. Cranberry is a small evergreen shrub grown in bogs in damp forests and open ponds. So many studies have been done on pharmacological activities of cranberry fruits.

 Key words: Vaccinium macrocarpon, Escherischia coli, urinary tract infections.


Aiming at the worsening urban ecological environment,the paper points out the improvement way,that is,the vertical urban building design,indicates the necessary reasons for the appearance of the vertical cities,and illustrates the vertical cities to relieve the contradiction between cities and environment,so as to provide a feasible road for the survival and development of human cities,and to have the design direction methods for the urban design and architectural design.


NONVERBAL BEHAVIOR OF YOUNG CHILDREN AS IT RELATES TO THEIR DECISION MAKING: A Report of Research Findings September 1970-1971 Since the purpose of education is to enhance the person, it would appear that the first and foremost prerequisite for any educational practice is a scrutinizing look at the person for whom education is intended. One way of studying the person is to examine his communication processes. The major purpose of this study was to examine the nonverbal behavior of young children in relationship to the decision making process. A critical aspect of the study was the development of the Nonverbal Behavior Category System, The nonverbal behaviors examined in this study were facial expressions, gesture, and body movement. Decision-making behaviors as used in this study were viewed on a less intentional-intentional continuum ranging from beginning or pre-decision behaviors which suggested little or no intent to middle or exploratory behaviors indicative of more intent to end behaviors which denoted strong intent or a child's absorption in or completion of a task. Design Subtects Subjects were University Nursery-Kindergarten children who were chosen to satisfy the folio ing criteria: a representative sample from Cr/ each of thl three age groups, and a comparable number of boys and girls. There were 10 subjects in the Pilot Study and 21 in the Principal Study.


This paper describes an adaptive control strategy that is suited for automatic control of mean arterial pressure. The performance of the control was evaluated for application of sodium nitroprusside, a vasodilator drug, using a computer simulation with a model of the patient response derived from actual patient data. One feature of the controller is its ability to optimize the quantity of infused drug without generating an offset in the controlled pressure. A comparison with another control strategy which has been employed in the clinics is presented.


Globally, there has been an increase in digital health interventions over the last decade. These interventions aim to improve maternal and infant health outcomes and treatment adherence, as well as HIV/AIDS education and prevention, immunization rates, and communicable disease prevention. The creation of digital health services that incorporated users' dynamic, multi-level, and complexities are crucial to the advancement of digital healthcare. These services are, at best, co-created by developers, community health workers, and government representatives. However, due to the presence of multiple stakeholders, the co-creation of digital health services is a complex process. The paper presents a case study of the digital health co-creation process, to understand and describe the activities taken by different stakeholders during a co-creation process. Additionally, the use of activity theory and a communicative ecology framework as analytical lenses to identify contradictions, as well as to gain insight into the co-creation of digital health services, are both presented in this paper.


An attitude survey and a role-playing case were used to identify the typical approaches people use to implement important changes in organixations. This typical strategy, suggested or used by over 90% of the subjects, was not successful in producing change in any of thefourteen role-playing trials. However, with ten minutes of instruction in the "Delta Technique," 86% of the subjects were suc cessful in introducing change in another fourteen role-playing trials. The "Delta Technique" consists of simple rules drawn from half a century of research.


Reconstruction of simulated microstructure from statistical microstructure descriptors attracts strong research interest due to its importance in materials design. A new methodology is presented in this paper to reconstruct robust microstructure with large number of representative volume elements which may acts as a stable input for deterministic method to simulate performance and effective properties. It is applied in carbon nanotube composite to demonstrate the capability of this method to generate robust microstructure while incorporating more statistical information on geometry, shape, anisotropy and spatial arrangement. Not only one point based statistical information, such as size, volume fraction, is taken into consideration, but correlation function is incorporated to cover information from geometry, shape and spatial correlation. Monte Carlo method was applied in reconstruction. Instead of using discrete image matrix, the information of geometric distribution of the nanotube composite is stored with the information of location of nanotubes. In this way, robust micrographs with large number of representative volume elements were generated for the future evaluation using finite element methods.


Niall Ferguson (b. 1964) is one of Britain's most talented young historians. He graduated with First Class Honours from Magdalen College, Oxford, and, after two years of scholarly research at the University of Hamburg, began to teach at Christ's College, Cambridge, in 1989. In 1992 he returned to Oxford, where he was appointed fellow and tutor at Jesus College, and in 2000 he became professor of political and financial history. By then, Ferguson had demonstrated his grasp of facts and his original interpretations of historical events and trends. His first major works were devoted to relatively narrow problems in economic history: paper and iron: Hamburg Business and German politics in the Era of inflation, 1897–1927 (1995), the pity of war: Explaining world war one (1997) [not so narrow—Ed.], and the world's Banker: the History of the House of rothschild (1998). Soon afterward, however, he switched to studying large-scale trends


The demand for higher data rates in communication networks raises the need for test equipment operating above 40Gb/s. PRBS generators are commonly used to provide test patterns for highspeed blocks such as MUX or CDR circuits. While generators with pattern lengths of 2-1 have been reported at rates of 100 Gb/s [1], a 2-1 pattern is required for testing CDRs to ensure that phase lock is maintained for data streams containing many consecutive ones or zeros. However, the high level of single-chip integration required for such long patterns above 40Gb/s remains an obstacle. Careful attention must be paid to system-level design and layout to ensure synchronous clocking of the 31 flipflops in the feedback shift register (FSR), even if the FSR is clocked with a half-rate clock or less. In this paper, a 2-1 PRBS generator in a 0.13μm SiGe BiCMOS technology with 150GHz-fT HBTs [2] is reported. The circuit is capable of producing output data rates of up to 72Gb/s, with manageable power dissipation, by using a high-speed low-voltage BiCMOS ECL/CML logic family.


A critical revi<:w of the possibilities of measuring the ~artlal pressure of sulfur using solid state galvanic cells )'n;;cd on AgI, C" , B-alumina, CaO-Zr02' Na2S04-I and doped ;:":;, ,,,Ilil "Iltl ,,11: auxiliary "jectrodes are presentlOu. SOIll..., df tllc!iL' sYHtcmH h,}vu inherent limltntlol1$ when <:xl'o" ...d to environments contilining both oxygen and sulfur. Electrode polarization due to electronic conduction in the solid electrolyte is a significant factor limiting the ;lC'e,"'acy of isotlwrm:l1 cell",. The electrochemical flux of{lit' !'\)ndlwl Ill}: Ion LhnHO',h tht' ('!('ctrojyt(~ C:Ul },(,! llIinlnliz(,{j pfUjJL!f cell. dL:~) i.t',11. Noni!:iot.herm~ll cells \.Jlth temperaLure compensated reference electrodes have a number of advantages over thC'ir isothermal counterparts.


Abstract The authors, who are lawyers and law professors, review how a common law court would use principles of civil tort law to decide whether a program of primary prevention would be potentially liable for damages to a person who claims to have been injured by the program. The authors review the basic principles – duty of care, breach of the standard of care, factual and legal causation, and damages – in the context of primary prevention and conclude that any such program has the potential for liability.


Non adherence is the major and unrecognized risk factor for the uncontrollable reduction for blood sugar.Type-2 diabetes mellitus and its complication are becoming more prevalent in India. Evidence abound that the most important predictor of reduction of morbidity and mortality due to diabetes complication is the level of glycemic control achieved through medication adherence.The purpose of this study was to evaluate the Medication adherence of patients with T2DM who received Insulin therapy and to identify other factors that can affect the medication adherence. A cross-sectional, observational study which was carried out for 6 months on Paul Moses Hospital in Chennai. A total of 100 patients with type 2 DM on insulin therapy for atleast 1 year were recruited. Blood Glucose level and other details of comorbidity were noted. 84% of patients were administered Insulin subcutaneously. Most common comorbidity observed in the diabetic patients was hypertension.  Medication Adherence was assessed using validated predefined questionnaire and adherence scores were calculated. The most common factors for non-adherence in male were too busy with their work (62.79%) and in female was inconvenience (62.79%). The p-value is < .05 reports that its significance incomparison of adherence and non-adherence.


Introduction: In practical settings of endovascular treatment,wesometimes encounter difficulties in treating lesions with massive thrombi, which may cause distal thromboembolism. Case Presentation: We encountered a case of severe critical limb ischemia involving in-stent iliac occlusion with massive thrombi. We had to overcome the critical issue of how to treat the massive thrombi in the iliac artery while avoiding thromboembolism. Therefore, we devised a very simple but possibly very useful protection system without any special devices based on the concept of the Optimo® balloon-tipped occlusion catheter. Conclusions: Although various endovascular treatment (EVT) devices and techniques have since been developed, little tips and tricks during EVT procedures are sometimes markedly useful.


Bacteriophages, viruses that are widespread throughout the world, are highly specific for bacteria, usually of a single species and often of a particular strain. After being discovered and isolated 100 years ago, their use, called phage therapy, was instituted in medicine two years later and quickly used around the world to treat various bacterial infections. In the West, phage therapy was overshadowed in the second half of the 20th century by antibiotic therapy, which was then thought to be the definitive solution. But because of the increase in bacterial resistance to antibiotics, the idea of using bacteriophages in medicine has been reawakened. The innumerable observations reported over the years in the literature constitute an invaluable experience. We and some of our colleagues have, in the last decade treated some patients compassionately. With the available documentation and our own experience we discuss the potential indications and limitations of phage therapy. The observation of the increasing number of therapeutic failures in the announced perspective of a post-antibiotic era, we believe, that the introduction of bacteriophages into the therapeutic arsenal seems conceivable today to two preconditions: that their production as biologic drug meets current regulatory standards and that the benefit-risk assessment was conducted in a modern setting. Phage therapy could be applied as a substitution or supplement to antibiotic therapy under multiple circumstances in different modes, precise indications and limits.


Along some subduction plate boundaries, slow deformation is observable as seismically detected deep low‐frequency tremor and geodetically detected slow slip events. These phenomena are considered as different manifestations of slow earthquakes characterized by fairly constant seismic moment rate. This paper presents a simple model of slow earthquakes that can explain wide variety of observed features including the steady moment rate and scaled energy, characteristics of tremor signals both in time and frequency domains, and the migration of the source location. In this model, slow earthquakes are represented as shear slip on circular faults whose radius is a random variable that is governed by a Langevin equation and three parameters, a diffusion coefficient, a damping coefficient, and a slip rate coefficient. This model expands on a previous scaling law for the slow earthquakes by providing a specific image of kinematics. Allowing for spatial variations of the parameters could potentially explain differences in behavior of slow slip events worldwide.


There is a high growth in the cases of intolerances and food allergies, and also a significant person's increase with dyslipidemia's. The market of foodstuffs for these individuals is still in development. Before this, the objective of the project developed an exempt fat cookie trans and gluten, subsequently to carry out sensory analysis of acceptance of the final product. The method used for the sensory analysis went to the scale hedonic structured of 09 points, where the prover chose an option in growing order from 01 to 09, where 01 is equal I upset it very much and 09 is equal to I liked very much. The team of the provers was done in random way, without distinction of sex, age and profession. The study was carried out in the dependences of the Federal Institute of Education, Science and Technology Inhabitant of Santa Catarina and it counted on 53 voluntary provers and not trained. The acceptability in the inquiry was considerably good, where the biggest punctuations were between 08 and 09 of the scale hedonic used.


Physicists will gather in Rome at the end of this month to celebrate the 100th anniversary of the birth of Enrico Fermi, one of the outstanding scientists of the 20th century. Awarded the Nobel prize in 1938 for his pioneering work in nuclear physics, Fermi also made notable contributions throughout many other areas of physics. And in Italy, the work of Fermi and his collaborators – known collectively as the School of Rome – paved the way for half a century of success in physics. But this success is under threat because bureaucracy and cronyism hold back many of the country's best young researchers.


This research explores the importance of financial management and fiscal responsibility for professional athletes. Professional athletes within the four major leagues earn a salary above six-figures, yet a previous report has suggested that over 78% of professional athletes within two years of retirement experience financial distress or file bankruptcy. Professional athletes earn large amounts of money over a short career span, which averages around 5 years or less where upon retirement, it is a drastic change socially and mentally for these athletes which a lot of them are not prepared for. Agents and financial advisors believe athletes' bankruptcies are completely preventable by helping them plan for the future through educated and smart financial management along the way. Document Type Undergraduate Project Professor's Name Emily Dane-Staples Subject Categories Sports Management This undergraduate project is available at Fisher Digital Publications: http://fisherpub.sjfc.edu/sport_undergrad/40 Running Head: PROFESSIONAL ATHLETES AND BANKRUPTCY 1 The Importance of Financial Management for Professional Athletes and the Prevention of Bankruptcy Christopher Danowski St. John Fisher College


1. Recent checklists of the freshwater fish of the British Isles have included 42 native and 13 introduced species. Of the former, however, two are extinct now and eight are threatened in various ways. In addition there are several important stocks of common native species under threat.

2. Protection for British fish exists mainly through legislation and protected sites of various designations. The legislation is inadequate in some respects and very few of the protected sites were actually established for their fish interest. Nevertheless, in Great Britain, 37 species of fish occur in National Nature Reserves. The overall status of fish in Sites of Special Scientific Interest is unknown.

3. The main conservation options for managing freshwater fish resources are habitat restoration, stock transfer to new sites, captive breeding and cryopreservation. The first two of these are regarded as the most useful for the long-term conservation of threatened species. Improved legislation would also help, especially in relation to preventing the import and transfer of potentially harmful species.

4. As well as the implementation of conservation management programmes for rare fish, research and monitoring studies are also needed in order to aid management and maintain a watch on populations of important species. In addition, national fish databases and registers of important stocks are an important background for overall fish conservation and management.


Lonelinees Scale for children was developed to measure children's perception of loneliness by Asher, Hymel and Renshaw in 1984. The purpose of the present study was conducted to determine the validity and reliability of the Loneliness Scale for children in Turkish society. The reliability study of the Loneliness Scale for Children on 287 primary school students revealed and internal consistency of the scale (cronbach alfa) .81, the test-retest reliability coefficient of 0.85 werw found. According to the confirmatory factor analysis which is applied for reliability, it was determined that Provision Loneliness Scale for Children can be accepted as a valid and reliable tool which can be used in Turkish society.


Background & Aim : A lack of efficient gene-delivery carriers has always been the biggest challenge in gene therapy. Polyethylenimine (PEI) and poly (L-lysine) (PLL) are the most studied non-viral gene carriers. The purpose of this study is to prepare new nano-carriers, by conjugating these two polymers via 10 carbon linkers (10-bromodecanoic acid), in order to take advantage of them and compensate their deficiencies for gene delivery aims. Methods : In this experimental study, two types of copolymers were synthesized. In the first step, a high molecular weight PLL (30-70 kDa) was considered as the core of the particle, and then the 10-carbon linkers were attached to the PLL relative to 10% and 50% of the PLL's amines. After that, the PEI polymer with an average molecular weight of 25 KDa was conjugated to PLL via linkers. The physiochemical properties of the synthesized carriers, cytotoxicity and gene transfer efficiency were evaluated in mouse neuroblastoma cells (Neuro2A). Results : The synthesized carriers were able to form polyplexes in nano-scale size (96-122 nm), and the carrier PLL-L10%-PEI was able to increase transfection relative to its base polymers (PEI and PLL); moreover, it also showed less cellular cytotoxicity in comparison with unmodified PEI. Conclusion : The best obtained nanoparticle in this study showed an acceptable charge (+8 mV) and proper nano-scale size (116 nm). This nano-copolymer increases the efficiency of transfection while it reduces cytotoxicity . Therefore, this nano-carrier is suggested for further gene delivery purposes to various cells.


This paper applies Markov model to evaluate the process of a random point walking on a line.Through the programming and simulation of this process by Matlab,the result shows that the simulation data is available in the confidence interval.


Facial pain is a debilitating disorder if left untreated. Too often, patients are labeled as having psychopathology when face pain etiology is unclear. These patients are categorized as "atypical," "idiopathic," or "psychogenic." Cases of facial pain involving neuropathic, neurovascular, musculoskeletal, as well as intracranial and extracranial systems will be reviewed. Peripheral and central mechanisms associated with these disorders are used to provide an update of these frequently seen clinical issues.


This article discusses the dynamic modeling for control of Gough–Stewart platform manipulator with special emphasis on universal–prismatic–spherical leg kinematics. Inverse dynamic model of these six degrees of freedom parallel manipulator robots is reviewed, while complete dynamics with true kinematics of universal–prismatic–spherical legs is compared with several models found in the literature. Most existing models have not taken into account some of the legs kinematical effects, namely the legs angular velocity around their axes and the internal singularities due to passive joints; some other used a simplified parameterization to describe the leg kinematics. Furthermore, some kinetic assumption can be used to reduce the computational burden. This article shows the effect of all these simplifications on the driving forces by simulating the different dynamic models for a commercial manipulator and for different sets of geometric and dynamic parameters of manipulator.


The transport of D-aspartate has been studied in an epithelial cell line from a pig kidney. The amino acid is accumulated by LLC-PKI cells without evidence of metabolism. The accumulation against a concentration gradient occurs through a mechanism with several features of a carrier-mediated process. The influx may be accounted for by a saturable Na+-dependent and nonsaturable Na'-independent process. The presence of Na+ in the incubation medium increases V,,, without affecting K,. A number of differences in the apparent affinities and specificities allows one to differentiate between this and the acidic amino acid transport system from other tissues. Polarized uptake from either side of the monolayers indicates that the acidic amino acid transport system is preferentially located in the apical membrane of the cultured renal cells. The apical localization of this system clearly contrasts with the basolateral localization of the other three neutral amino acid transport systems reported previously, indicating a high degree of cell polarization. The present study shows a close similarity between the Na+-dependent acidic amino acid transport system in LLC-PKI cells and the system present in the apical membrane of the proximal tubular cells.


I have been studying the process of designing and generating stories. In doing so, I have focused on how the characteristics of stories change depending on the presence or absence of external stimuli [1]. This paper is focused, first, on the effects of availability heuristics, termed cognitive biases in this paper, such as the selective use of memory. I explore the process by which different teams given the same data set create different stories.


ABSTRACT The shoreline assessment process is an integral component of oil spill response, providing assistance in decision-making and documentation for shoreline cleanup. The process consists of de...


This chapter contains sections titled: Introduction Service, Student Engagement, and Retention Beyond Service-Learning Engineering Service-Learning in the Classroom The Florida Gulf Coast University Story Course Assessment Course Redesign and Justification, Version I Course Redesign, Version II Course Redesign, Version III Conclusions


Introduction: Life expectancy is the number of years that people in a given country or population can expect to live. Dramatic gains in life expectancy have been made globally since 2000, but major inequalities persist within and among countries of different human development. Aim of the research: To identify determinants of life expectancy in countries that have low and medium human development index. Material and methods: The study was conducted from January 1, 2018 to April 15, 2018 using the most recent aggregates of health indicator data from the WHO, World Bank, UNDP, and UNICEF databases in 83 countries with low and medium human development. The dependent variable was life expectancy, while the independent variable was socio-economic, healthcare related, and morbidity variables. Data was compiled in excel and analysed using SPSS version 21. A linear relationship was drawn between variables and presented in tables. Results: Life expectancy was shorter in the studied countries and varied enormously among countries. A significant relationship between life expectancy and socio-economic, healthcare, and morbidity indicator variables was observed. There was an inverse and significant linear relationship between life expectancy and young age dependency rate, total fertility rate, child mortality rate, and a positive relation with HDI, adult literacy rate, contraceptive prevalence rate, HIV incidence rate, and TB incidence rate. Conclusions: Life expectancy is determined by multiples of socio-economic factors, health and health care system associated factors, disease burden, and their complex interactions. Therefore, policy and programs targeted to improve life expectancy should consider population dynamics, socio-economic influence, and health system factors.


Abstract . Metallicity gradients are most frequently investigated directly from galaxies observed in emission. We have shown that galaxies detected via strong quasar absorption lines also exhibits a metallicity gradient in the outskirts and circumgalactic medium out to ~40 kpc distance. We infer a metallicity gradient of −0.022 dex kpc−1 for absorption-selected systems at redshifts 0.1 z 3. Applying this metallicity gradient and a flattening of the gradient beyond 12 kpc, we demonstrate that absorption-selected galaxies obey the same mass-metallicity relation (MZR) as observed for luminosity-selected galaxies.


Grid storage is a new technique and has developed rapidly for recent years.The application of grid storage technology will supple technological basement for the mass data storage administration and utilization of PACS.


The current global food crisis — decades in the making — is a crushing indictment against capitalist agriculture and the corporate monopolies that dominate the world's food systems. The role of the industrial agrifood complex in creating the crisis (through the monopolization of input industries, industrial farming, processing, and retailing) and the self-serving neoliberal solutions proposed by the world's multilateral institutions and leading industrial countries are being met with skepticism, disillusion, and indifference by a general public more concerned with the global economic downturn than with the food crisis. Neoliberal retrenchment has met growing resistance by those most affected by the crisis — the world's smallholder farmers.This article can also be found at the Monthly Review website, where most recent articles are published in full.Click here to purchase a PDF version of this article at the Monthly Review website.


Seven years ago, SC Johnson—A Family Company approached Gateway Technical College with a need to further strengthen their incumbent workforce's technical training and education. Retirements, brain drain, and competition for technical expertise were the forces driving SC Johnson to develop a comprehensive, flexible, and timely workplace education initiative. SC Johnson employees formed an Education Advisory Council to assess employee training needs. The original goal of the Education Advisory Council was to offer SC Johnson employees on-site opportunities to develop electrical and mechanical skills. Employee participation and increased interest in training opportunities led the Education Advisory Council to recommend expanding and diversifying course offerings, and ultimately the link program was launched. "Link" stands for learn, integrate, and know and serves as the mission statement of the Education Advisory Council. SC Johnson sought a partner to share both their exceptional commitment to education and the resources, talents, and opportunities to create and run a state-of-the-art Employee Training Center. Gateway Technical College was the ideal partner who could cooperatively participate in a program that met SC Johnson's training needs, yet afforded flexibility, expertise, and timeliness. The link story highlights the needs, opportunities, challenges, solutions, resources required, results achieved, and lessons learned when private and public entities collaborate to provide on-site training. Accredited by the North Central Association of Colleges and Schools, the SC Johnson Employee Training Center is Gateway Technical College's fourth official campus.


Computer use in the Philippines has been rapidly growing but the use and integration in the fi eld of nursing is not yet fully developed and required. The principal stage in using computer technology in nursing is the assessment of computer competency level and attitude. A questionnaire was distributed among 172 nurses to determine their competency level in basic computer operations; multimedia and fi les management; and internet and social networking and communications using a validated and reliable tool that was developed; while Pretest on Attitude toward Computers in Health Care (PATCH) was utilized to determine their attitudes. ANOVA and Pearson r was used to determine the relationship and differences among groups and an enhancement program was also formulated based on the fi ndings. Results show that the respondents are highly competent in all domains of computer competencies but just a comfortable level of attitude. Age, educational attainment, rank, internet access and years using computers were factors that affect competency level whereas age, rank and years using computers are variables in attitude. Computers in Support of Nursing Education, Research and Operations (CISNERO) program was developed to further enhance the skills of nurses in using computers. It aims for cohort focus; IT-Nursing collaboration; standardized protocols; nursing-informatics introduction; education and staff development; research engagement and utilization; organizational structure. La Union nurses are capable of using computers and ready for the use of computers in nursing management toward safe and quality care. Age, sex, educational attainment, rank, internet access and years using computers affects competency level and attitude toward computers. CISNERO Program can develop the use of computers in nursing in the Philippines.


Possible to obtain a motor with a high-performance sintered bearing and sintered bearing summary task cost to. The dispersion concentration distribution of the solid lubricant powder which is mixed into the bearing base powder solutions bearing powder material, continuously or stepwise varied in the axial direction or radial direction, such as site high load is applied by high density segregation required site individuals lubricants such, the amount of solid lubricant powder configured to improve the bearing function without much increase, the relatively amount of expensive solid lubricant possible to increase the bearing function without increasing the the ones. Select Diagram Figure 2


Amides, thioamides, ureas, and thioureas were N-acetylated in good yield with acetic acid in the presence of methyl bis(1-naphthyl)bismuthinate at room temperature.


This paper presents a novel approach to the rotor position estimation of a switched reluctance motor (SRM). The complexity involving the conventional flux estimation techniques is eliminated by introducing an artificial neural network (ANN) based estimation method. Back Propagation based training algorithm used in this method provides adequate and accurate training which makes it possible to achieve angular position values with high precision. With a sufficiently large training data, the ANN can build up a correlation for flux, current and theta. Using these values we can deduce accurate position of the rotor which can be further used in speed control techniques, effectively obliterating the need for a conventional speed sensor. The simulation results validate the accuracy and reliability of this method.


Considerable progress has been made in high-energy physics research on several fronts during the present contract year. Analysis of the data from ZGS polarized beam experiments E-460 and E-462 has continued and is nearing completion. This, along with our data from LAMPF E-504/505, will have considerable bearing on the question of dibaryon resonances. Work has continued on the project to accelerate polarized-proton beams in the Brookhaven AGS. One of our contributions to this project, the 200-MeV polarimeter, will be completed, calibrated, and installed in the AGS LINAC during this contract year. The combined proposal E-704 for the first-round polarized-beam experiment at FNAL was approved and an agreement was reached among the various collaborators and submitted to the laboratory. The first run of the hadron-jet-calorimeter experiment, FNAL E-609, was completed during this contract year. Data analysis is underway which will constitute three Ph.D. theses for Rice students. We have also investigated additional future directions for the program, such as neutrino oscillation studies, high energy e-p collisions, underground detectors, and experiments at LAMPF II.


Born at the end of the nineteenth century at a time of the introduction of mass schooling, the notion of "literacy" is current in many fields of the arts and humanities.

Keywords:

class;
cultural history;
Egyptian history;
gender;
Greek history;
history of science, medicine and technology;
history of the book and printing;
Late Antiquity


This paper examined teachers' commonly held cognitions on use of instructional media in English language pedagogy among secondary school teachers of English in Kenya. It focuses on teacher beliefs, knowledge and thoughts on instructional media and how they interact with classroom pedagogical practices. Fifteen schools were stratified as National, Extra County, County and Sub-county to obtain 45 participants comprising fifteen (15) heads of department sampled purposively and thirty (30) teachers of English who were randomly selected. Data was generated using interviews, lesson observation and document analysis. The study was guided by Vygotsky social learning theory. Qualitative approach and Multiple Case study method were utilized. Data was analyzed qualitatively based on the themes and sub- themes arising from interview transcripts and observation notes. The findings of the study revealed that teachers have cognitions about the use of instructional media and these cognitions in turn shape classroom pedagogical practices. Preparation of instructional media was said to be time consuming and their utilization in language lessons was minimal.


PurposeBlockchain-based traceability technology (BTT) is an emerging digital technology that claims to have the potential to fulfil the demand for traceability to safeguard fruit safety. Drawing on the technological, organisational and environmental (TOE) framework, this study aims to investigate the perceived facilitators and barriers that influence the behavioural intentions of multiple stakeholders in the Vietnamese fruit supply chain (i.e., farmers, trading enterprises and consumers) to adopt BTT.Design/methodology/approachThis study utilised a qualitative approach of semi-structured in-depth interviews with 60 stakeholders in the Vietnamese fruit supply chain to achieve the research objectives. NVivo 12 was employed to analyse the collected data using content and thematic analysis.FindingsThe findings identify several perceived facilitators that motivate BTT adoption. These include trust, transparency, business performance, the formation of alliances, consumer awareness of food safety and ethical agricultural practices, fruit branding and the pivotal role of farmers' cooperatives. Meanwhile, the perceived barriers to BTT adoption include a lack of digital literacy amongst the stakeholders, poor organisational culture, the high cost of traceability-enabled products and data privacy and security governance.Practical implicationsThis study suggests that technology awareness and perceived facilitators and barriers should be incorporated into the design and deployment of blockchain-based traceability technology in the agri-food supply chain in developing countries.Originality/valueTo the best of the authors' knowledge, this study is the first qualitative paper that attempts to fill the research gap of understanding the perceived facilitators and barriers that influence the intentions of multiple stakeholders in the fruit supply chain to adopt BTT in the context of a developing economy.


The paper puts forward a new method, named Binomial Expansion Advantage Method, to calculate the kill probability for an antiaircraft weapon system to kill an air target by direct hits. It is obtained by improving the original common useful method—Binomial Expansion Method. The new method keeps the features of easy practice and high computation speed had by BEM, and in a certain degree overcomes the weakness of relatively great round error of BEM in its computing process of calculating the combination number Ck N by a computer. Finally, the paper compares their precision and difference of the calculation methods in computing the killing probability with an example.


Economic historians have long been divided over whether the industrial revolution led to an increase of skill among the factory workforce.2 One reason for this continuing disagreement is that the process of skill formation is difficult to observe directly. Historians have thus tried to identify changes in the stock of skills available from changes in levels of illiteracy, or from the proportion of the workforce completing apprenticeships. Neither measure indicates skill formation accurately. Industrialization may have called for a more adaptable and eventually a more literate workforce, but until the i830s changes in rates of literacy in Britain, as well as their links to the process of industrialization, are uncertain both in direction and in pace.3 Similarly, apprenticeships are a poor guide to the amount of on-the-job training in the industrial revolution. By the end of the eighteenth century, laws governing apprenticeships were widely regarded as anachronistic.4 In practice they were abused or ignored by employers, or if upheld were used mainly as a barrier (especially against females) to entry into skilled trades, rather than as a vehicle for training labour.5 An alternative approach suggested by human capital theory is to measure skills formation through observing the lifetime earnings profiles of workers. The basic idea behind human capital theory is that people enhance their earning capabilities by investing in themselves (i.e. by creating human capital) in much the same way that earnings may be increased by investing in physical capital.6 The simplest way to think about human capital is that it is the quality of labour or the set of skills (though human capital includes much more than skills) which enables a worker to perform at a higher standard. The opportunity cost of acquiring these skills may be seen as investment, in that the time spent training could have been used in paid


The field of cancer immunotherapy has led to successful treatments such as monoclonal antibodies (MAb), inhibitory receptor (IR) blockade, and adoptive cell transfer (ACT). ACT modified to express chimeric antigen receptors (CARs) can redirect T cells to tumor antigens and has shown remarkable clinical efficacy in patients with relapse and refractory leukemia and lymphoma. 90% of pediatric patients with acute lymphoblastic leukemia (ALL) respond to CD19 CAR T cell therapy (CAR T19), although only 26-35% of patients with chronic lymphocytic leukemia (CLL) show complete responses (CR). It is unclear why responses are less frequent in CLL compared to ALL. The heavy pre-treatment received by CLL patients likely contributes to lower response rates with CAR T cell therapy, and disease progression is worsened due to profound T cell defects characterized by elevated expression of IRs such as PD-1 and CTLA-4. Fraietta et. al. assessed CLL patient apheresis samples and CART19 products to show that CR was associated with elevated levels of CD27+PD1-CD8+ T memory cells whereas the non-responders (NR) showed an exhausted phenotype with high levels of multiple IRs. We studied 14 patients with advanced, heavily pretreated CLL who received at least one dose of CART19. Patients with CRs exhibited high in vivo expansion and persistence of infused CAR T cells, as opposed to NR's. Importantly, at peak levels of in vivo CAR expansion, NR's had elevated levels of CTLA-4 expression which correlated with poor CLL patient responses to CART19 therapy. In summary, these data suggest that eliminating CTLA-4 mediated T cell inhibition can be clinically beneficial. Thus, we tested the hypothesis that disruption of CTLA4 would improve CAR T cell efficacy in CLL based on numerous observations. Our data demonstrate that knockout (KO) of CTLA-4 in T cells from healthy donors using CRISPR Cas9 technology leads to maintenance of surface CAR expression and higher tumor clearance in a chronic re-stimulation model using CART19 cells against NALM6 tumor cells. In xenograft models of ALL, KO of CTLA-4 increases the anti-tumor efficacy of CART19 cells. We then performed CTLA4 disruption in T cells banked from CLL patients that did not respond to CAR T cell therapy to determine whether dysfunctional CAR T infusion products can be invigorated by CTLA-4 KO. In both chronic re-stimulation model and xenograft models of NALM6, CTLA-4 KO CD19 CAR T cells from CLL patients maintained surface CAR expression, exhibited enhanced tumor clearance, and higher survival rates relative to subject-matched unedited CAR T cells. Thus, suggesting that CTLA4 disrupted CAR T cell products may enhance the success rate of CAR T cell therapy for CLL patients. This technology can be feasibly expanded to other tumor indications to increase the overall efficacy of CAR T cells. These IND-enabling studies will support the translation of this therapy to the clinic.
 Citation Format: Sangya Agarwal, Angela Aznar Gomez, Tong Da, Shunichiro Kuramitsu, Weimin Kong, Pranali Ravikumar, Mercy Gohil, Megan M. Davis, Joseph A. Fraietta, Gabriela Plesa, David L. Porter, Regina M. Young, Carl H. June. Disruption of cell-intrinsic checkpoint regulator CTLA-4 in CD19 directed CAR T cells provides clinical efficacy in CLL patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5571.


Abstract As cities and urban population continue to grow, causing serious threats to public health, the development of health-affirming urban landscapes becomes even more important topic than ever before. The purpose of this paper is to answer the question which qualities of urban landscape make it the health-affirming landscape. In the first part of the paper, a concept of health-affirming landscapes and a modern approach to sustainable city design are examined. In the second part, the qualities of health-affirming urban landscape according to theories and research are discussed. The tools, which might be applied to urban design to create health-affirming landscapes are reviewed. The conclusions concern the need and possibilities to create health-affirming landscapes. The need for further research on impact of such landscapes on health and well-being of city dwellers is indicated.


Based on the bibliographical research, the present study seeks to examine the main changes and reflexes that the new Code of Civil Procedure of 2015 has brought to the area of family law, as well as the innovations that involve the techniques of conflict resolution, with the purpose of presenting the changes, impasses and benefits of the main procedural changes inherent to family law, and to highlight the impetus that the procedural code brings to the application of new pacifying methods to solve conflictual demands in the juridical-family scenario. To this end, a study was carried out through relevant doctrines and legislation, as well as other scientific articles and researches, and it was concluded that the new civil procedural law brought about major changes and some refinement of the conflict, especially with regard to family matters, which, as will be shown, is a stimulus to the consensual solution founded and established by the sides themselves.


The standard sublimation enthalpies of 2,4-dichlorophenoxy acetic acid, 2,4-dichlorophenoxy propionic acid, and 2,4-dichlorophenoxy butyric acid and their methyl esters 2,4-dichlorophenoxy acetic methyl ester and 2,4-dichlorophenoxy butyric methyl ester were determined by direct differential scanning calorimetry (DSC) measurements along with the Langmuir and torsion effusion methods. For 2,4-dichlorophenoxy acetic acid, 2,4-dichlorophenoxy propionic acid, and 2,4-dichlorophenoxy butyric acid, the values ΔsubH°(298 K) = {(122 ± 5), (127 ± 8), and (137 ± 10)} kJ·mol-1, respectively, were selected. For 2,4-dichlorophenoxy acetic acid methyl ester and 2,4-dichlorophenoxy butyric acid methyl ester, the ΔsubH°(298 K) final values 89 kJ·mol-1 and 100 kJ·mol-1, respectively, were selected with an estimated error of ±10 kJ·mol-1. From torsion data, the standard sublimation entropies for 2,4-dichlorophenoxy acetic acid, 2,4-dichlorophenoxy propionic acid, and 2,4-dichlorophenoxy butyric acid equal to ΔsubS°(298 K) ...


It relates to a light-emitting block by using the solar cell, and an object thereof is to provide a light-emitting block structure with no restrictions on how the location and installation and simultaneously increase the light emitting area. In case the present invention and surrounding the outermost side, and provided with the transparent portion, a light emission occurs in the transparent portion to the front for this purpose; Light emitting means which is provided on the rear of the transparent portion inside the case, transmitting sunlight; Inside the case is installed at the rear of the light emitting means, light receiving solar cell section to produce power at the sun passing through the transparent portion and the light emitting means; A capacitor for receiving the inside of the case and the power storage the electricity generated from the solar cell section; And provides a light-emitting block by using the solar cell having a configuration in which a control unit for controlling the storage and supply of electric power to power storage capacitor to the light emitting means to the inside of the case. Light-emitting blocks, the solar cell, the light guide plate


Dynamic analysis of a partially-filled tanker train traveling on a curved track is studied in this paper. A partially-filled tanker is dynamically modeled when it is traveling along a real curved track. For three classes of tracks, rail irregularities are randomly generated by using Monte-Carlo simulation. An equivalent dynamic system is used to model sloshing motion of the fluid. Two derailment indexes i.e. derailment quotient and unloading ratio are obtained numerically as safety indicators. A parametric study is carried out to investigate how different parameters like the operational speed, fluid modeling, rail irregularities, and fluid density may affect the derailment potential. It is found that descending of the center of gravity and consequently reduction of the moment arms is more dominant than the oscillating forces due to sloshing motion.Copyright © 2008 by ASME


Abstract : The Institute for Laboratory Animal Research (ILAR), formerly a component of the Commission on Life Sciences (CLS) within the National Research Council (NRC), is now part of the Division on Earth and Life Studies (DELS) following a reorganization of the NRC that involved consolidation of various components. Partial support for ILAR has been provided for many years from the Department of the Army to enable ILAR to fulfill its mission. ILAR was founded in 1952 and has become a national and international leader in developing guidelines for animal care, breeding, and use; descriptions of animal models for human diseases and physiological processes; and reports on specific issues of humane care and use of laboratory animals. ILAR's mission is to help improve the availability, quality, care, and humane and scientifically valid use of laboratory animals and to disseminate its reports and other relevant information to the biomedical and laboratory animal science communities. ILAR accomplishes its goals through its core program, which is carried out by the staff, and its special-project program, which is carried out by NRC-appointed committees with staff assistance. The number of committees and size of the staff are dependent on the number of special projects and available funding. A 15-member Council composed of experts in laboratory animal medicine, zoology, genetics, medicine, ethics, and related biomedical sciences directs both programs. The Army funds partially support general office operations, the Animal Models and Genetic Stocks Information Program, publication of ILAR Journal, and work of the Council.


The article reveals sociocultural aspects of the mental diseases stigmatization in the con text of the social changes in the Russian Federation within the recent decades. The interrela tions between the stigmative attitude and the deeply transformed notions of public morals and ethics in the contemporary society are described. The difference between the attitude and reac tions of the psychiatric clinics older and younger generation personnel is highlighted.


Sodium cyanide is traditionally used in chemical me tallurgy to obtain preciousus metals (gold and silver). Cyanide produces damages because of it s toxicity and breath cell inhibition. Here we try a biotechnological process to degrade cyanide with P. fluorescens obtained by cyanide heap leaching process in gold metallurgy in Segovia, Colombia. In Colombia cyanide heap leaching process in gold metallurgy is not controlled and cyanide is used excessively. It means that great quantities of sodi um cyanide are lost in sands and in waste water. To xicity tests made by D. pulex show less than 54 ppm of cyanide is enough to kill them. Traditional treatments to cyanide degradation are useful and normal but they are expensive. Microbiological process eliminates c yanide successfully and cheap.


Comrade Mao Zedong's On Handling Correctly Internal Contradictions among the People is an ideological crystallization of socialist practice with Chinese characteristics and a theoretic epitome of developing Marxism in practice.This work of Mao Zedong profoundly reveals the basic contradictions of Chinese socialism and composed a new chapter of developing Marxism theory in China.It is not only a philosophical cornerstone of exploring the socialist road with Chinese characteristics,but also a theoretic base of building a harmonious socialist society.It witnesses that the socialism theoretic system with Chinese characteristics follows the same guideline with Mao Zedong Thought.


The primary macular atrophies are of sufficient rarity and interest to warrant the report of a classic case of the Schweninger-Buzzi type of cicatricial atrophy. The interesting feature is the linear distribution of the lesions on the shoulders and upper part of the back, a fact which coincides with Schweninger and Buzzi's original description.1 REPORT OF CASE History.— J. B., a white woman, married, aged 26, was first seen in June, 1929, at St. Mary's Dispensary where she sought treatment for "spots" on her body. The family history was unimportant. There was no history of any cutaneous diseases in the parents or relatives. The patient had mumps and tonsillitis in childhood, typhoid at 12 years of age and lobar pneumonia three times. She also gave a history of eleven induced miscarriages. She said that she never had a venereal disease or any of the symptoms of one. There was no


The crystal structure and magnetic properties of a LaCo10Al3 intermetallic compound have been investigated by x-ray powder diffraction and magnetic measurement. The space group of the LaCo10Al3 structure is I4/mcm, which can be derived from the cubic NaZn13-type structure. Each unit cell contains four formula units of LaCo10Al3. The lattice parameters are a=8.085(1) Angstrom, c=11.624(8) Angstrom, and the calculated density is D-x = 7.07(3) g/cm(3). In each unit cell, there are five kinds of equivalent positions, i.e., 4a, 16l(1), 16k 16l(2), and 4d, which are occupied by 4La, 16Co((1)), 16Co((2)), 1G(Co+Al) and 4Co((3)) atoms, respectively. The tetragonal LaCo10Al3 intermetallic compound is ferromagnetic with a Curie temperature of 840 K. The magnetic moment per Co atom is 0.84 mu(B), which can be explained by the magnetic valence model. (C) 1996 American Institute of Physics.


The Nikki Regional Livestock Cooperative (UCOPER-Nikki) was concerned when Benin's national government made local authorities responsible for livestock markets. They knew that improved markets and infrastructure were essential to their economic future and a reliable, safe livestock/meat supply for customers locally and in southern Benin, Nigeria and Togo. A cooperative managed market was proposed in partnership with local government. Three years later the market is a reality. Total sales in 2011-13 approached $10 million USD, and the market is more profitable for producers, with positive impacts along the value chain including feed and animal health, livestock trade and processing, retailers and consumers.


Abstract Aluminum (Al) has many detrimental effects on plant growth, and shoots and roots are normally affected differently. A study was conducted to determine differences among sorghum [Sorghum bicolor (L.) Moench] genotypes with broad genetic backgrounds for growth traits of plants grown at 0,200,400,600, and 800 μM Al in nutrient solutions (pH 4.0). Genotypes were categorized into "Al‐sensitive", "intermediate Al‐tolerant", "Al‐tolerant", and SC 283 (an Al‐tolerant standard). As Al increased, shoot and root dry matter (DM), net main axis root length (NMARL), and total root length (TRL) became lower than controls (0 Al). Aluminum toxicity and/or nutrient deficiency symptoms become more severe, and shoot to root DM ratios and specific RL (TRL/root DM) values also changed as Al in solution increased. Root DM had greater changes among genotypes than shoot DM, and NMARL at 400 μM Al, and TRL at 200 μM Al had greater differences among genotypes than root DM, ratings for toxicity and/or deficiency symptoms, a...


Before the discovery of insulin therapy in 1921 and the development of effective oral hypoglycaemic therapy in 1926, pharmacological management of diabetes mellitus was restricted to empirical treatment often based on plant products and relegated to folklore medicine. One therapy reputed in Malta as useful for the management of diabetes mellitus in 1927 was Fenugreek. This has now been shown to have definite pharmacological properties that controls blood glucose levels in diabetic subjects.


A method for measuring the surface tension of free standing smectic films is described which is considerably more precise than the methods used up to now. Data on the precision and the reproducibility of the device are presented. The temperature dependence of the surface tension for the smectic liquid crystal 4-octyl-4′-cyanobiphenyl is discussed.


The article deals with the integration of the technological control systems of building holdings with a continuous cycle of processing and production of small series and individual products. As part of a unified system of holding management information view of units with varying levels of automation, distributed geographically has been described. Algorithms for reconfiguration control systems of technological equipment as a result of operational monitoring have been offered. The problems of integration of the local units in a distributed holding control system with intelligent and predictive control based on neural network coordination have been considered.


Sinder, B P; Eddy, M M; Caird, M S; Marini, J C; +Kozloff, K M +Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, BEMB, National Institute of Child Health and Human Development, NIH Bethesda, MD firstname.lastname@example.com INTRODUCTION Osteogenesis imperfecta (OI) is a genetic bone disorder characterized by brittle bones with high propensity to fracture. Presently, bisphosphonates are widely used to treat children who have OI. A new bone anabolic agent, sclerostin antibody (SclAb), may be beneficial for treatment of OI, where reduced rates of osteoblast activity have been identified. The anabolic nature of the SclAb may be beneficial in reversing this phenotype of reduced bone formation, thus increasing bone mass and reducing fracture risk. The purpose of this study was to investigate short-term SclAb treatment in Brtl/+ mice, a well characterized model for OI. We demonstrate that SclAb therapy increases trabecular and cortical microCT parameters via anabolic mechanisms which increase the mineralizing surface of osteoblasts in Brtl/+ OI bone.


Let $C$ be a smooth projective curve of genus $g \ge 1$ over a finite field $\F$ of cardinality $q$. In this paper, we first study $\#\J_C$, the size of the Jacobian of $C$ over $\F$ in case that $\F(C)/\F(X)$ is a geometric Galois extension. This improves results of Shparlinski \cite{shp}. Then we study fluctuations of the quantity $\log \#\J_C-g \log q$ as the curve $C$ varies over a large family of hyperelliptic curves of genus $g$. For fixed genus and growing $q$, Katz and Sarnak showed that $\sqrt{q}\left(\log \# \J_C-g \log q\right)$ is distributed as the trace of a random $2g \times 2g$ unitary symplectic matrix. When the finite field is fixed and the genus grows, we find the limiting distribution of $\log \#\J_C-g \log q$ in terms of the characteristic function. When both the genus and the finite field grow, we find that $\sqrt{q}\left(\log \# \J_C-g \log q\right)$ has a standard Gaussian distribution.


We investigated the correlation between the crystallite size, resistance to oxidation, and phase transition of Ge-doped Fe3O4 nanocrystalline thin films. We prepared thin films on water-cooled glass substrates by radiofrequency sputtering with Ge-tipped α-Fe2O3 ceramic disks as targets. The addition of Ge caused a reductive phase transition from α-Fe2O3 with a corundum structure to Ge-doped Fe3O4 with an inverse spinel structure, resulting in a crystallite size of <10 nm. We annealed three samples with average sizes of 5, 8, and 10 nm by changing Ge addition concentrations at 673 K in air for up to 323 days until reaching near-thermal equilibrium. All samples maintained their magnetization at almost a constant value over long-term heat treatment. The results of Raman spectroscopy and optical transmittance spectroscopy suggest that there was a phase transition to Ge-doped γ-Fe2O3 at 5 nm, Ge-doped Fe3−δO4 with iron vacancies δ at 8 nm, and Ge-doped Fe3O4 at 10 nm. In other words, we retained Fe3O4 down to a relatively small crystallite size of 10 nm because of the improved oxidation resistance imparted by Ge doping.


On international scale the Codex Alimentarius Standard for Named Vegetable Oils differentiates between virgin oils and cold-pressed oils, while in Germany virgin, non-refined and refined oils are available. Here cold-pressed is an additional quality feature. The paper explains and comments the various definitions for vegetable oils other than olive oil obtained by mechanical extraction only, because they are partly contradictory.

Resulting from gentle processing virgin oils are often appreciated by the consumers as the better oils. The answer of the present paper to the question which type of oil is better is that there is no better or worse oil, but only a better or worse suitability of an oil for application in food processing or the kitchen.

Finally, the paper picks up the upcoming debate on the potential 'new' contaminant, 3-MCPD-fatty acid esters, which were found in refined oils.


Objective To observe the clinical effects of tremetazidine on venerable age patients of angina pectoris of coronary heart disease.Methods Seventy two patients were divided into conventional treatment group(35 cases ) and tremetazidine group (37 cases, treated with additional tremetazidine) .Break out times,degree of angina pectoris,change of liver function and kidney function, lipis, rates of heart beats, and side effect were recorded before and after the treatment for the two groups cases.Results After treatment, angina pectoris had reduced clearly in tremetazidine group(P0.01),and movement-endurance had increased (P0.05). The improvement was shown on the electrocadigraphy for both groups .No adverse reaction was related to the tremetazidine group.Conclusion Tremetazidine is safe and effective to treat angina pecteris for venerable age patients of corenary heart disease in the long term.


Sorafenib is a drug that has been verified to be effective on hepatoma cells. Three series of diaryl ethers have been designed and synthesized based on the structure of sorafenib. The 5m compound shows better inhibitory potency against HepG2 cells (IC50 = 1.96 μM) than sorafenib (IC50 = 9.61 μM). These results have been verified with MTT assay and colony-forming assay. Moreover, compound 5m exhibits good antitumor activities against PLC/PRF5, HeLa, A549, and HT-29 cell lines. The excellent bioactivity of compound 5m confirms that a single optical conformation is superior to the racemate. A western blotting analysis indicates that compound 5m induces the apoptosis of HepG2 cells by enhancing the protein levels of p21 and Cl-caspase3.


The actions of thc hippocampal formation were studied by recording the electrical activi-tics of a single neuron of that area.Two different reactions of some neurons in CA2,CA3 and thedentate gyrus ntight occur after peripheral noxious stimulations,that is,increase of the reaction frc-qtcncy of the nociccptive cxcitcd neurons(NENs)and decrcasc of the macron frequeency of thenociocptive inhibited neurons(NENs).Flctrical acuptmcture of the"points"would result in inhib-iting cffcet on most of the NENs but disinhibiting cffcct on NENs.Identical effect to that ofacupunctre could be creatcd by injecting morphine to the expcrimental animals.Electricalstimulation of thc nucleus raphc magnus or peri-aqueduct gray mattcr could affcct the NENs andNINs in the hippocampus,and the results were similar to that of acupucture.When 5-HT was in-jccted into thc latcral ventricle or applied to thc hippocampal neurons through micro-iontophoresis,effects similar to that of acupuncture also occurred.These facts imply that the effects of peripheral"point"acupuncture on the eletrical activities of the neurons of the hippocampal formation might be rre-lated to the activities of the cndogenous serotoninergic neurons,or to the cndogenous morphine-likesubstance.The NENs would be inhibitod after large amounts of GABA were injected into the lateralventricle.The relationship between this phcnomenon and the acfivites of GABAergic intenrons inthe hippocampus awaits furthcr investigation .


The addition of Lewis bases L to the methyl(methylidene)boranes MeB=CA2(A = SiMe3) and MeB=CAA′ (A′ = SiMe2Cl) gives the adducts MeB(L)=CA2 (1a, b; L = trimethylpyridine, PMe3) and MeB(L)=CAA′ (1c, d; L = di- and trimethylpyridine), respectively. Alcohols and amines HX are added to the BC double bond to give boranes MeB(X)—CHA2 (8a—c; X = OiPr, OtBu, NiPr2); MeB=CAA′ and HNMe2 react in the ratio 1:2, yielding MeB(X)—CHA(SiMe2X) (2d; X = NMe2). From MeB=CA2 and BH3, the five-membered ring [—CA2—BH—CA2—BMe(Hm)2BMe—] (2e; 2:1) or the six-membered ring [—CA2—BH(Hμ)2BMe—CA2—BH(Hμ)2BMe—] (2f; 1:1) are formed, both containing double hydrogen bridges; the product 2f crystallizes in the space group P1¯. The metallocene trihydrides [Cp2MH3] add to the BC double bond under formation of a double hydrogen bridge to give [Me(A2CH)B(Hμ)2MCp2] (2g, h; M = Nb, Ta). MeB=CA2 can be chloroborated, -stannated, and -phosphated with E—Cl to yield the boryldisilylmethanes MeB(Cl)—CA2—E (2i—l; E = EtClB, tBuClB, Me2ClSn, Cl2P). The alkyloboration and -alumination with E—R leads to the boryldisilylmethanes MeBR—SiA2—E (2m—o; E—R = Me2B—Me, Et2B—Et, Cl2Al—Et) and the bromination to MeB(Br)—CA2Br. (2+2) Cycloadditions are achieved, when MeB=CA2 is reacted with unsaturated molecules a=b, yielding four-membered rings [—BMe—CA2—b—a—] [4a—d; a=b = fluorenone, bis(methoxycarbonyl)ethyne (reacting at both of the C=O bonds), phenylisocyanate (reacting at the C=O bond), N-isopropylacetoneimine], or with triple bond systems RC≡Z, yielding four-membered rings [—BMe—CA2—Z=CR—] (4e—g; RC≡Z = PhC≡CPh, AC≡CCl, tBuC≡P). With a series of six molecules with an element-oxygen double bond, a primary (2+2) cycloaddition is followed by a metathetical splitting of the transient four-membered rings 4h—m. One of the metathesis products is MeB≡O, which is identified as boroxene (MeBO)3, the other component is an alkene RR′C=CA2 [starting from MeB=CA2 and PhCHO, PhC(Me)O] or an alkene RR′C=CAA′ (starting from MeB=CAA′ and PhCHO, tBuCHO) or the methylidene phosphorane Ph3P=CA2 (starting from MeB=CA2 and Ph3PO) or the dicarbadicobaltatetrahedrane [(CA)2{Co(CO)3}2] {starting from MeB=CA2 and [Co2(CO)8]}. The (2+3) cyclodaddition of MeB=CA2 to the azide X2PN3 (X = NiPr2) as 1, 3-dipole gives the five-membered ring [=BMe—CA2—N=N—NX=] (5a) and to RN3 the rings [=BMe—CA=N—NA—NR=] (5′b, c; R = iBu, A; formed from the cycloadducts 5b, c by migration of A); analogously, [=BMe—CA′=N—NA—NA=] (5′d) is formed from MeB=CAA′ and AN3. Finally, the nitrone O—NMe=CHPh and MeB=CA2 or MeB=CAA′ give the corresponding (2+3) cycloadducts 5e, f, respectively. All of the products were characterized by their 1H, 11B, and 13C NMR spectra.

Reaktionen an der Bor-Kohlenstoff-Doppelbindung von Methyl(methyliden)boranen

Die Addition von Lewisbasen L an die Methyl(methyliden)borane MeB=CA2 (A = SiMe3) und MeB=CAA′ (A′ = SiMe2Cl) fuhrt zu den Addukten MeB(L)=CA2 (1a, b; L = Trimethylpyridin, PMe3) bzw. MeB(L)=CAA′ (1c, d; L = Di- und Trimethylpyridin). Alkohole und Amine HX addieren sich an die BC-Doppelbindung unter Bildung von MeB(X)—CHA2 (2a-c; X = OiPr, OtBu, NiPr2); MeB=CAA′ und HNMe2 reagieren im Verhaltnis 1:2 zu MeB(X)—CHA(SiMe2X) (2d; X = NMe2). Aus MeB=CA2 und BH3 bilden sich der funfgliedrige Ring [—CA2—BH—CA2—BMe(Hμ)2BMe—] (2e; 1:2) oder der sechsgliedrige Ring [—CA2—BH(Hμ)2BMe—CA2—BH(Hμ)2BMe—] (2f; 1:1), die beide Wasserstoff-Doppelbrucken enthalten; der Sechsring 2f kristallisiert in der Raumgruppe P1¯. Die Metallocentrihydride [Cp2MH3] addieren sich an die BC-Doppelbindung unter Bildung einer Wasserstoff-Doppelbrucke zu [Me(A2CH)B(Hμ)2MCp2] (2g, h; M = Hf, Ta). MeB=CA2 kann mit E—Cl zu Boryldisilylmethanen MeB(Cl)—CA2—E chloroboriert, -stanniert und -phosphaniert werden (2i—l; E = EtClB, tBuClB, Me2ClSn, Cl2P). Die Alkyloborierung und -aluminierung mit E—R ergibt die Boryldisilylmethane MeB(R)—CA2—E (2m—o; E—R = Me2B—Me, Et2B—Et, Cl2Al—Et) und die Bromierung MeB(Br)—CA2Br (2p). (2+2)Cycloadditionen beobachtet man, wenn MeB=CA2 mit ungesattigten Molekulen a=b zu Vierringen [—BMe—CA2—b—a—] [4a—d; a=b = Fluorenon, Bis(methoxycarbonyl)ethin (an beide C=O-Bindungen wird addiert), Phenylisocyanat (an die C=O-Bindung wird addiert), N-Isopropylacetonimin] oder mit Dreifachbindungssystemen RC≡Z zu Vierringen [—BMe—CA2—Z=CR—] reagiert (4e—g; RC≡Z = PhC≡CPh, AC≡CCl, tBuC≡P). Mit sechs Verbindungen mit einer Element-Sauerstoff-Doppelbindung folgt auf eine primare (2+2)-Cycloaddition eine metathetische Ringspaltung. Eines der Metatheseprodukte ist MeB≡O, das als Boroxin (MeBO)3 nachgewiesen wird, das andere ist ein Alken RR′C=CA2 (aus MeB=CA2 und PhCHO, PhMeCO) oder ein Alken RR′C=CAA′ (aus MeB=CAA′ und PhCHO, tBuCHO) oder das Methylidenphosphoran Ph3P=CA2 (aus MeB=CA2 und Ph3PO) oder das Dicarbadicobaltatetrahedran [(CA)2{Co(CO)3}2] {aus MeB=CA2 und [Co2(CO)8]}. Die (2+3)-Cycloaddition von MeB=CA2 an das Azid X2PN3 (X = NiPr2) als 1, 3-Dipol ergibt den Funfring [=BMe—CA2—N=N—NX=] (5a) und an das Azid AN3 die Funfringe [=BMe—CA=N—NA—NR=] (5′b, c; R = iBu, A; hervorgegangen aus den Cycloaddukten 5b, c durch Wanderung von A); entsprechend bildet sich [=BMe—CA′=N—NA—NA=] aus MeB=CAA′ und AN3. Schlieslich entstehen aus MeB=CA2 bzw. MeBB=CAA′ und dem Nitron O—NMe=CHPh die (2+3)-Cycloaddukte 5e, f. Alle Produkte wurden mit Hilfe ihrer 1H-, 11B- und 13C-NMR-Spektren charakterisiert.


Web Server Monitoring System is one of the important systems to whom that concerned about the information from the web server log file. The target user of the
system is network administrator or websites holder. When clients access to a particular websites hosted by the web server, some information, :tor example, their IP address, the domain they accessed, date and time, web browser used or operating system used, will be stored in the log file, either access log file or error log file. These information is the important for the admin users or websites holder, where they need to analyze which
domain is the most popular website, or the errors generated as long as the web server is ready to receive client's request. The system is capable to analyze those data from access log file and error log file. The data will then pass to MySQL database and stored it for
future used. Each time the users run Web Server Monitoring System, the data from the database will be fetched out and make comparison or enhancement by using PHP script language. The enhanced data will then display in the web browser in a simple manner. For example, a simple is used to list out all the IP address from the log file rather than users have to read it line by line in traditional environment.


Objective: To evaluate the health status, age of menopause, and its symptomatology amongst Himachali middle-aged women. Materials and Methods: A community based cross-sectional study was done from Jul 07 to Jan 08. A structured questionnaire was given to 100 menopausal women from general community of Himachal Pradesh in Shimla. Results: Mean age of menopause was 44.54 years. Main symptoms associated with menopause were reported as fatigue (62%), hot flashes (56%), Cold sweats (52%), and backaches (51%). Other ailments associated with menopause were arthritis (25%), hypertension (23%), and diabetes (6%). Conclusion: Mean age of menopause was 44.54 years. Chief comorbid conditions were arthritis and hypertension.


Purpose – The purpose of this paper is to frame collaboration in supply chain as a hierarchical reflective construct.Design/methodology/approach – This study uses data from industries in India to test the hierarchical and structural model. Partial least squares method is used to test the model.Findings – Results show that collaboration is a third‐order, reflective construct. The paper's findings also arrange collaborative activities in terms of its importance for collaboration.Practical implications – Collaboration is a multi‐facet activity and is a meta‐concept, and therefore this paper improves our understanding on the subject. The performance of supply chain collaboration depends on the execution of various activities, and this paper points out how the various activities are related to the collaboration, the execution of which will drive collaborative ventures towards success.Originality/value – This paper provides empirical evidence for collaboration as a hierarchical reflective construct. The model i...


Now a days there is large number of accidents deaths increased when they are not able to get the right help at right time.By overcoming this basic problem, we are going to develop the IOT based solution.This smart accident rescue system is going to give the best solution by the help of automatic ambulance service with some IOT concepts. When the accident occurs, there should be the third person to inform about the accident to the nearby ambulance, police station and one of the family members [1].According to this project when a vehicle meets with an accident immediately sensors will collect the information about the accident and send it to Microcontroller. Microcontroller find the location coordinates of accident spot using GPS and sends the alert message including geographic location coordinates through the GSM Module to ambulance, nearby police station and one of the family members.So, the rescue team in the ambulance can immediately reach the location coordinates in Geolocation.


We show that for Gibbs measures on self-conformal sets in () satisfying certain minimal assumptions, without requiring any separation condition, the Hausdorff dimension of orthogonal projections to k-dimensional subspaces is the same and is equal to the maximum possible value in all directions. As a corollary we show that Falconer's distance set conjecture holds for this class of self-conformal sets satisfying the open set condition.


This paper presents the setup for power amplifier measurement using the vector network analyzer that accompanies the internal directional coupler. In addition, the procedures of s-parameter and power calibrations are introduced. The obtained results are presented and discussed.


Fractional calculus is a hot topic in recent years.In this letter,the model of time-delayed fractional-order neuron network system is constructed.And the equation of the system is resolved.The chaotic behavior is studied.Based on this,the scheme of synchronization system consisted of time-delayed fractional-order neuron network system is constructed,the synchronization condition is found and validated by simulation.


Pharyngoesophageal or Killian-Jamieson diverticulum is due to herniation of the mucosa and submucosa of the pharynx through a potentially weak area of the pharyngeal wall. It originates on the anterolateral wall just below the cricopharyngeous. It can be detected incidentally during thyroid ultrasonography (US). We present here a case report of pharyngoesophageal (Killian-Jamieson) diverticulum mimicking a thyroid nodule on US. We discuss the image findings that might be useful for the differential diagnose and to prevent invasive procedures such as needle aspiration biopsy.


Undergraduate women who varied in how much they valued health were exposed to written communications persuading them of their vulnerability to osteoporosis and of the effectiveness of a recommended action in preventing this disease. Vulnerability had a significant main effect on intentions and subsequent behavior. This effect was obtained regardless of how much the subjects valued their health or whether the coping response was effective. Intentions to perform the recommended behaviors proved to be the best predictors of self-reported and actual behavior change, in support of the Ajzen-Fishbein (1980) model. Intentions, in turn, were predicted from recipients' beliefs regarding their ability to perform the behavior, their vulnerability to the health threat, and the effectiveness of the recommended threat-reducing response. Implications of these findings for health promotion campaigns are discussed.


Abstract We describe changes in glaciers of the Balkhash-Alakol basin, central Asia, and analyse unified glacier inventories of the Zailiyskiy-Kungei and Jungar glacier systems and the Chinese part of the Ili river basin, as well as mass-balance monitoring data from Tsentralniy Tuyuksu glacier for the period 1957-2014. In spite of significant inter-basin differences, glaciation of the three glacial systems in the Ili river basin within Kazakhstan as well as within Chinese territory is changing simultaneously and similarly. Differences in the rates of glacier degradation are small and are affected primarily by the orientation of the flanks of the mountain ridges. Since the mid-1950s, glaciation of the region has remained degraded and, on average over the period examined, glaciers shrank at a rate of about 0.8% a-1 in area and about 1 % a-1 in ice volume. Glacial systems in large basins such as Balkhash-Alakol change simultaneously, linearly and at similar rates. The average rates of glacier reduction of the Zailiyskiy-Kungei, Jungar and upper Ili glacier systems for the period 1955/56-2008 amounted to 0.76%, 0.75% and 0.73% a-1 respectively.