Efficient management and control of modern and next-gen networks is of paramount importance as networks have to maintain highly reliable service quality whilst supporting rapid growth in traffic demand and new application services. Rapid mitigation of network service degradations is a key factor in delivering high service quality. Automation is vital to achieving rapid mitigation of issues, particularly at the network edge where the scale and diversity is the greatest. This automation involves the rapid detection, localization and (where possible) repair of service-impacting faults and performance impairments. However, the most significant challenge here is knowing what events to detect, how to correlate events to localize an issue and what mitigation actions should be performed in response to the identified issues. These are defined as policies to systems such as ECOMP. In this paper, we present AESOP, a data-driven intelligent system to facilitate automatic learning of policies and rules for triggering remedial actions in networks. AESOP combines best operational practices (domain knowledge) with a variety of measurement data to learn and validate operational policies to mitigate service issues in networks. AESOP's design addresses the following key challenges: (i) learning from high-dimensional noisy data, (ii) capturing multiple fault models, (iii) modeling the high service-cost of false positives, and (iv) accounting for the evolving network infrastructure. We present the design of our system and show results from our ongoing experiments to show the effectiveness of our policy leaning framework.


A two-band transport model is proposed to explain electrical conduction in graded aluminum gallium nitride layers, where the free hole conduction in the valence band is favored at high temperatures and hopping conduction in the impurity band dominates at low temperatures. The model simultaneously explains the significantly lowered activation energy for p-type conduction (∼10 meV), a nearly constant sheet conductivity at lower temperatures (200–330 K), and the anomalous reversal of the Hall coefficient caused by the negative sign of the Hall scattering factor in the hopping conduction process. A comparison between the uniform and graded samples suggests that compositional grading significantly enhances the probability of phonon-assisted hopping transitions between the Mg atoms.


SP1 Comparison of the general movement assessment and the test of infant motor performance with cerebral magnetic resonance imaging in very low birthweight infants C PEYTON, L ADDE, E YANG, MD SCHREIBER, T FJORTOFT, ME MSALL 1 Comer Children's Hospital, The University of Chicago, Chicago, IL, USA; 2 Clinical Services, Physiotherapy Section, St Olaf University Hospital, Trondheim, Norway; 3 Kennedy Research Center on Intelectual and Neurodevelopmental Disabilities, The University of Chicago Comer Children's Hospital Center for Developmental and Behavioral Pediatrics, Chicago, IL, USA


HE troubles man has with his teeth receive universal attention, all the way from folk remedies to quiet fretful teething infants to the deposition of cast teeth in the grave with their possibly long-toothless owner. References to the lore of the teeth are scattered but vast in number, covering the range from decay and treatment to loss and disposal of teeth. Anyone familiar with the long, white roots of teeth will not be surprised to learn that from ancient times tooth decay has been ascribed to a worm in the tooth. This is reflected in a Babylonian cure for toothache in which the priest performs the role of Ra (the sun-god), reciting a part of a creation myth while the "worm" causing the toothache is brought into contact with the priest, who then curses the worm.' Similarly, John Abercromby in Pre-and Proto-Historic Finns relates how the dental decay worm was formed from spittle spat upon the water by Syjojatar (a toad). For seven summers the waves rocked the spittle and the sun baked it, and at last the worm, so formed, washed upon the shore where it was seen by "three daughters of Nature," who queried, "What would become of this if the Creator created life, put eyes into its head by spells?" Overhearing this, one Husi "gave life to it . . . then into a snake it turned, it transformed to a dusky worm," which took it upon itself to go about causing toothache.2 There was, apparently, no corner on the idea that a worm lay at the base of the aching tooth, for a Latin poem of the eleventh century in the Regimen Sanitatis Salenitanum says,


There is an increasing demand to reduce cost and shorten the development period. Though an automation system consists of sub-systems, each sub-system is large. Therefore, the development of such a system is complex. In addition, an automation system, in which there are a wide variety of object requests, may not achieve the processing performance of the target depending on the combination and arrangement method of the sub-systems. Thus, it is important to design appropriate configuration. We propose a design support method using modelbased simulation. This method predicts total system performance by extracting the constraints arising from the system configuration and patterning the various input data. We appliedthis method to the design of configurations of embedded system composed of multiple processing sub-systems. In the result, the most reasonable configuration was designed from two patterns of system configuration.


The impact of the 1994 North American Free Trade Agreement (NAFTA) on relatively disadvantaged groups, including Mexican women, has provoked heated debate for over a decade and continues to divide opinions on NAFTA's merits. This study uses a differences-in-differences approach to examine how NAFTA affected the female labor participation rate (FLP) in different Mexican regions. NAFTA increased FLP only in central Mexico, through the creation of female employment opportunities. Specifically, NAFTA caused female intensive export production to expand in central Mexico, and reduced the ability of domestic firms to discriminate against women by increasing product market competition.


In this paper,an automatic dim small target detection for hyperspectral IR imagery is researched,according to target detection RX algorithm model,the algorithm performance evaluation index in point target detection for hyperspectral is presented,the pixel number of detector,the number of bands which affect the algorithm performance are analyzed.based on RX algorithm and RX improved algorithm,in experiments on AVIRIS hyperspectral IR imagery,the correlation matrix application advantage in hyperspectral target detection algorithms is analyzed,Automatic detection of a target is proposed,UTD algorithm is verified to have a good detection results with specific band dependence in the target detection.Theoretical analysis and simulation results showed that the RX algorithm is Effective in automatic target detection for Hyperspectral IR Imagery.


A method includes forming a hard mask over a substrate, patterning the hard mask to form a first plurality of trenches, and filling a dielectric material into the first plurality of trenches to form a plurality of dielectric regions. The hard mask is removed from between the plurality of dielectric regions, wherein a second plurality of trenches is left by the removed hard mask. An epitaxy step is performed to grow a semiconductor material in the second plurality of trenches.


This article explores how citizens are being engaged in an important area of policy making – the budget – and suggests ways in which budget officials can use the powerful resource of the Internet to further that involvement.


With the lithium-ion battery industry moving to high energy density anode materials such as silicon and lithium metal as a substitute for lower specific capacity carbon-based materials like graphite, cathode energy density can become a bottleneck. Typical cathodes have less than 10% practical specific capacity compared to both pure lithium metal and silicon. For these anodes, cathodes with higher active material loadings per unit area would be needed to produce matching electrode pairs. However, cathode thickness cannot indefinitely be increased, as doing so leads to issues with electrolyte transportation, conductivity, and mechanical properties [1,2].
 Increasing the loading of the cathode could also be done by reducing the amounts of inactive components, such as the binder and the conductive additive, in the electrode. To achieve this, understanding the role of each component is important. The most important role of the binder is to act as an adhesive among particles and the current collector. But most binders are electronically insulating. The main role of the conductive additive, such as carbon black, is to improve the conductivity of the overall system [1].
 As the inactive material percentages are decreased, the distribution of these components in the electrode domain becomes more important to both the electrochemical and mechanical performance of the electrode. The distribution changes with the different process conditions used, such as mixing techniques, order, speeds, times, slurry viscosity, drying conditions, etc. This research consists of a systematic study to understand the effects of the aforementioned process conditions on the particle and polymer distribution as well as its contribution to the mechanical and electrochemical performance. With the use of the current findings, the active material percentage was increased up to 98% in electrodes with 5 mAh/cm2 loading, retaining similar performance to electrodes with 92.8% active material, as shown in figure 1. Some contribution of the capacity fade was found to be due to the lithium counter electrode used.
 The goal of this ongoing project is to produce a model that could be applied to different materials to identify the best process conditions for thick electrode manufacturing.
 References

 F. Ma, Y. Fu, V. Battaglia, R. Prasher, Microrheological modeling of lithium-ion battery anode slurry, J. Power Sources, 438 (2019), p. 226994

 Wen Yu, Nanping Deng, Lin Tang, Kewei Cheng, Bowen Cheng, Weimin Kang, Roles of metal element substitutions from the bimetallic solid-state electrolytes in lithium batteries, Particuology, 65 (2022), p. 51-71

 Figure 1


At present, our country mention strategy of "use informationization to promote industrialization" and emphasize its importance.Using the informationzation of the computer to manage, promoting enterprise's modernized management level has already become the common understanding.According to actual conditions of some workshop, based on tradition MIS, this paper develop the shop floor management and control system, controlling and monitoring workshop produce in real time, satisfied with the requirement of accelerating the speed of response to the market, improving production efficiency and resource utilization ratio, improving information flow, etc.


This paper deals with the characterization of the metrological performance of digitizers so that they can be used for metrology applications. Apart from dc behaviour such as linearity, stability, and noise, especially the dynamic performance of the digitizers is important and thus the measurement of AC flatness, phase, and sample jitter are essential. We present here first results of characterizations of precision sampling voltmeter when DC signals are digitized, with respect of some parameters such as aperture time, "dead" time and autozero.


Reflected the relationship between the ruler and the ruled on the political situation of the State directly, the relationship was strong cooperative system was stable investigators to the interests of the nation, which set this relationship in the Islamic Shura legislation governing the methods of decision-making and passage of legislation, laws and amended, and as the field of political legitimacy was rare texts must rely on rules established jurisprudence, and the study of a Shura model, to show the extent to which the rules jurisprudence to the nation and met the requirements for goods political resorted to a study interests achieved, it is conducive to cooperation between members of the nation, and stimulate scientific research, and generous energies nation, and give an atmosphere of love and integration between the ruler and the ruled.


It provides a process (100) using a contact sensor for measuring conductivity of the low conductivity of the liquid sample. The method (100) comprises a first driving frequency applied to the first excitation current (102) to a contacting-type conductivity sensor. Determining a first voltage in response to the first excitation current (104). Higher than the first driving frequency applied to the second excitation frequency of the second drive current (106) to the contacting-type conductivity sensor. Determining a second voltage in response to the second excitation current (108). At least in part on the first and second voltages in response, provides an output electrical conductivity (110). Conductivity is also provided a system for measuring a conductivity of 100μS / cm or less than 100μS / cm liquid (10) is used.


Holographic data storage is promising for space applications because the wide spatial distribution of each data bit provides a natural resistance to radiation damage. One potential medium for such a system is bacteriorhodopsin (BR), a photochromic material obtained from the bacterium halobacterium salinarium. A response time on the order of a microsecond, along with its low fatigue and high spatial resolution make BR a promising medium for optical data storage. In this paper, we explore the required exposure and read intensities, along with possible data densities, for D85N/D96N BR.


MATLAB is a high efficient project calculation and programming language,containing numerical calculation,visibility and programming.While many numerical calculations are hold in remote sensing digital image processing,this article introduces the method to do calculations using MATLAB,meanwhile with programming simply and efficiently it illustrates distinct applications in the handling remote sensing digital image with MATLAB.Therefore,MATLAB provides a fresh method of thinking.


Purified myelin fractions were prepared from brains of control and EAE sensitized guinea pigs on the 5th, 9th and 15th day after injection of antigen. Lipid classes were quantified and expressed as per cent of micromol contents of phospholipids and galactolipids, and fatty acid compositions each of them were analyzed.


THE ELECTROTHERMAL METHOD IS A NONDESTRUCTIVE TESTING METHOD APPLICABLE TO METAL PARTS AND STRUCTURES. WELDS MAY BE TESTED FOR VOIDS, CRACKS AND SLAG INCLUSIONS. RELATIVELY COMPLEX MACHINED OR CAST PARTS MAY BE TESTED. MODERATE SURFACE WAVINESS DOES NOT AFFECT THE TEST. TO APPLY THE ELECTROTHERMAL METHOD, THE SPECIMEN IS SUBJECTED TO AN ELECTRICAL CURRENT PULSE TO DEVELOP A SURFACE TEMPERATURE DISTRIBUTION THAT IS INDICATIVE OF INTERNAL DEFECTS. THIS DISTRIBUTION IS MAPPED BY INFRARED OR OTHER THERMAL IMAGING TECHNIQUES, SUCH AS THE APPLICATION OF THERMOGRAPHIC PHOSPHOR OR LIQUID CRYSTAL. DEFECT INDICATIONS ARE SUPERIMPOSED UPON THE NORMAL TEMPERATURE PROFILE OF A GOOD PART OR WELD, BUT CAN USUALLY BE EASILY SEPARATED FROM THE NORMAL PROFILE. /AUTHOR/


The fully-functional succinct tree representation of Navarro and Sadakane (2014) [2] supports many operations in constant time using 2n+o(n) bits. Since the full idea is hard to implement, only a simpli ed version with O(lg n) operation time has been implemented and shown to be practical and competitive. Cordova and Navarro [1] describe a new variant of the original idea that has worst-case time O(lg lg n) for the operations and is much simpler to implement. An implementation based on this version is experimentally shown to be superior to existing implementations.


The distance to the black hole binary GX 339-4 remains a topic of debate. We examine high-resolution optical spectra of the Na D lines resolving the velocity structure along the line of sight. We find this to be complex, with at least nine components, mostly blueshifted, spanning a velocity range of nearly 200 km s-1. The presence of components with a large blueshift rules out a nearby location and requires that the binary be located at or beyond the tangent point, implying a lower limit to the distance of ~6 kpc. The presence of a significant redshifted component at +30 km s-1 is even more intriguing, as GX 339-4 also has a slightly positive systemic velocity, suggesting that the source, and this cloud, could be on the far side of the Galaxy, where the radial velocities due to Galactic rotation become positive again. If this is the case, we require a distance of ~15 kpc. This is less secure than the 6 kpc lower limit, however. We discuss the implications of these possible distances for the outburst and quiescent luminosities, as well as the nature of the companion star, and argue that a large distance explains these characteristics. In particular, it would explain the nondetection of the companion star during the faintest states.


AbstractIn search of an answer to the questions of what a knowledge society is and how it emerges we draw connections between the macro-institutional theory of the American political economist Douglass C. North and the theory of micro-social mechanisms of the Swedish sociologist Peter Hedstrom. North considers the institutional framework of a society as determining, in principle, the structure of economic opportunities and incentives for social actors. Actors acquire those types of knowledge and skills that they perceive most "valuable" or "profitable" and, at the same time, using the acquired types of knowledge and skills, they perceive possibilities for new opportunities and incentives, i.e. for changing the institutional framework. In addition to being influenced by the structure of economic incentives, the actors' perception of value/"profitability" is also impacted by "mental constructs", which actors use in order to interpret the world around them. In Hedstrom's view, on the other hand, desires, beliefs and opportunities of social actors determine their actions, which, in turn, have an impact on desires, beliefs and opportunities, and thus also the actions, of other actors. Desires and beliefs roughly correspond to the mental, while opportunities correspond to the structural component of the North's approach. These theories imply that a society in which (1a) the majority of its members want to be successful and believe that success can be achieved only by investing an effort, and in which (1b) a system of rewards according to merits has been established - such a society will considerably differ from a corrupt society (2a) comprised of the majority desiring success, but believing that it can most expeditiously be achieved by exploiting social connections to powerful actors, and in which (2b) clientelism and corruption are not adequately sanctioned. Development of a knowledge society can be influenced (1) by developing a corresponding institutional framework of opportunities and incentives, (2) by disseminating an appropriate narrative through various modalities of public discourse in order to influence desires and beliefs of social actors, and particularly (3) through acting by example, which provides a means to prove credibility of proclaimed intentions.Keywords: acting by example; dissection; incentive structures; individual desires, beliefs and opportunities; knowledge society; mental constructs; self-fulfilling prophecies; social institutions.1. IntroductionSoon after the Croatian Prime Minister Ivo Sanader resigned from all duties in the Government and the Croatian Democratic Union (HDZ) party, Croatian society has had to come to grips with a host of adverse social phenomena that were not adequately addressed during his term of office. Clientelism, corruption, nepotism and other social evils have all been confronted more directly only since Sanader's departure.3The heritage of Sanader's incumbency includes a vast "political industry" - an estimated 10,000 members of various local, regional, and national representative bodies, entirely or at least partially financed from public sources (Kasapovic, 2012). Moreover, a large part of this huge apparatus is comprised of political clientele, who usually compensate for lack of their own abilities by exploiting political, kinship and other ties, and occupy influential governing positions, from which they can use budgetary funds to purchase favors from their patrons. At the same time, they also sell benefits to novice clients, similar to themselves, and recruit them to positions next to theirs, widening thus the clientelist network through all the hierarchical levels and sectors of the Croatian society.This pattern of manipulating public budgetary funds in order to maximize personal benefits for local power-holders we shall call a "corrupt society". The aim of this article is to point to the importance of "dissecting the social",4 and particularly of dissecting a corrupt society, in order to draw preliminary lessons on how to construct a new, healthier, knowledge society that would encourage development of deeply and essentially human attributes, such as curiosity, creativity, diligence, caring for public goods, a sense of meaning and value. …


A 40 1 tank reactor, filled to 3 % (v·v −1 ) with a small size (5-25µm) carrier material and equipped with a mechanical mixer, was used to create a sludge bed system for anaerobic waste water treatment. Solids leaving the tank with the effluent were recycled to the tank from an external settler. Two different substrates were used, fodder molasses diluted with tap water and beet sugar factory waste water. Influent concentrations were 9.3 g COD·1 −1 and 4-7 g COD·1 −1 respectively, and treatment was performed at 35-37 °C. With the synthetic molasses waste water, an organic load of 5-6 kg COD·m −3 ·d −1 could be tolerated, with the sugar industry waste water 25 kg COD·m −3 ·d −1 . The difference in loading capacity was ascribed to different types of sludges formed, the molasses waste water resulting in a much more bulky sludge and a lower attainable volatile suspended solids concentration. It was concluded that much care must be exercised before designing sludge bed systems for high loads with unhydrolyzed waste waters.


Over the past two decades, many governments around the world have taken notice of the detrimental impact of the construction industry on the environment and have initiated plans to promote sustainable construction practices. These plans range from offering incentives that motivate construction firms to adopt sustainability up to imposing penalties on non-conforming firms that develop projects that pollute the environment. This paper presents a research study that targets to provide an insight on the impact of different governmental policies on the adoption levels of sustainability by construction developers in an emerging construction market, specifically the Qatari construction sector. This insight is achieved through the development of an agent-based model loosely based on the diffusion models of Rogers and Bass, which describe the adoption process of new products in a population formed of units of adoption. Our model showed that using agent-based modelling and prominent diffusion models can be helpful in understanding how construction firms would react to different governmental policies that target to increase the adoption of sustainable construction practices.


As a domestic embedded CPU core of proprietary intellectual property rights,CK-Core has been widely used in various situations.In order to meet various application needs of CK-Core based processors,more powerful peripheral interfaces are required.A kind of peripheral extension interface was introduced,which has a bright future for application-SDIO interface.Based on the analysis of the SDIO specification,a SDIO Host Controller IP of CK-Core based processor was developed.The IP verification was done under RVM platform and also FPGA platform.The design was synthesized in Synopsys DC.The results indicate that this self-developed IP has been reasonably designed and works well,which improves the peripheral extension capability of the CK-Core based processor.


Aim: To assess the expresion of Bcl-2 and P53 proteins in brain after hypoxic-ischemic brain damage (HIBD) as well as the relationship to apoptosis in the neonate. Methods: The HIBD model was established with 7-old-day Wistar rats. The expression of Bcl-2 and P53 proteins as well as the relationship to apoptosis after HIBD in the neonatal rat were deter- mined by immunohistochemistry and terminal deoxynucleotidyl transferase mediated dUTP-biotin nick end labelling (TUNEL) staining. Results: Apoptosis coexisted with necrosis after HIBD by TUNEL, but apoptosis was a major form of cell death. Bcl-2 immunostaining ranged from week to intense (+ + - + + + ) in the brain of normal neonatal rat. After hy- poxia ischemia (HI), a decrease or absence in immunoreactivity for Dcl-2 in apoptotic and necrotic neurons was observed. The expression of P53 immunoreactive protein was not detected in the brain of normal neonatal rat, but strong P53-immunoreac- tive was found in apoptotic and necrotic cells. Conclusion: The expression of Bcl-2 decreased. while P53-immunoreative in- creased. Overexpression of Bcl-2 protects cell from apoptosis, but Bax may be function as a cell death effector protein.


Every child when born into the world, he brings various types of innate intelligence unique to one another. Children's intelligence is one aspect of the child's initial ability to understand every pattern and understanding in thinking. Multiple intelligences are one of the intelligences that can help find characteristics in early childhood. With this expert system, it is hoped that it can become a medium for parents to find the dominance of intelligence in early childhood. The method of identifying children's intelligence used in this system uses forward chaining and certain factors which retrieve intelligence data from several sources and published journals. The results that this researcher wants is to find dominance intelligence in early childhood as well as an assessment of user satisfaction with the application.


Convexity performs the appropriate role in the theoretical study of inequalities according to the nature and behaviour. There is a strong relation between symmetry and convexity. In this article, we consider a new parameterized quantum fractional integral identity. Following that, our main results are established, which consist of some integral inequalities of Ostrowski and midpoint type pertaining to n-polynomial convex functions. From our main results, we discuss in detail several special cases. Finally, an example and an application to special means of positive real numbers are presented to support our theoretical results.


Background: Nigeria, annually, has the highest numbers of death from breast cancer (BC) in Africa, estimated at 10,000. While BC incidence is declining in many parts of the world, it is increasing in Nigeria. Delay in BC diagnosis in Nigeria is due to: i) health care professionals (HCPs) and patients having poor knowledge of BC causation and symptoms; ii) incorrect diagnosis of symptoms; iii) delay in treatment seeking; iv) use of ineffective/harmful treatment methods.1 Low literacy rates, fear of cancer and the cultural taboos associated with BC create communication hurdles difficult to overcome.2 Aim: Increased HCP and patient of knowledge of BC causes, symptoms and detection, and improved communication between HCP and patients, resulting in increased and improved diagnostic protocol adherence, more patients self-reporting symptoms, and ultimately down-staging of patients. Methods: i) Aggregation of historical data of participating clinics of patients BC stage at diagnosis; ii) survey of HCP knowledge of BC symptoms and diagnostic protocols before and after seeing Worldwide Breast Cancer´s (WBC) Know Your Lemons (KYL) education materials; iii) frequency of display of KYL posters in clinics; iv) HCP survey of frequency of BC health discussions during a clinic visit; v) pre- and postsurvey of patient knowledge, interest and willingness to report symptoms at community education sessions, vi) count of number of patients reporting symptoms while making/attending clinic appointments. Results: Increase in HCP knowledge of symptoms and diagnostic protocols before and after seeing the KYL education materials; more visible use of patient friendly BC education materials displayed in the clinic; increase in frequency of breast health discussions initiated by HCPs with their patients; improved patient interest and knowledge of symptoms and diagnostic protocols; increase in patient confidence in being able to recognize a BC symptom; increase in patients making clinic appointments and self-referring symptoms to HCPs. Conclusion: As proven in other parts of the world with the KYL education materials, the researchers aim to prove, in undertaking this study in Lagos, Nigeria, that training HCPs (e.g., patient navigators, community workers, primary care physicians, mammography technicians) and patients in the signs/symptoms and risk factors for breast cancer using WBC´s bright, appealing and eye catching KYL materials can improve how HCPs and patients communicate about BC symptoms and detection option, which leads to earlier stage of diagnosis. 1. Agba et al, 2012; American Cancer Society, 2011; Cancer Today, 2012; Ogundipe, 2011; Osain, 2011; Prevalence of Breast Cancer, 2015. 2. Okpara and Kabongo, 2011; Total Facts Nigeria, 2017; World Atlas, 2017.


Economic benefit maximization, as the basic target of the enterprises' financial management, is the most important concern of the financial management professionals.How to compute and control all kinds of enterprise's cost, especially the capital costs, has become the priority of the enterprises. This paper compares the Capital Asset Pricing Model and the Arbitrage Pricing Model which are the common theories in computing the capital costs. It is important for decision makers of financial management to understand these two models and respective advantages. Furthermore, the investors of equity capital can benefit from these two models when they invest because the models can optimize capital combination, mitigate risks and realize the maximum investment return.


This paper presents two implementations of finite control set model predictive methods applied to AC/DC converters with an LCL filter. The LCL filter in contrast to L filter offers higher level of harmonics attenuation. However, despite its advantages, LCL filter can cause a strong resonance in grid current. The proposed control strategy, i.e. PCi2uc-3L uses basic advantages of the MPC methods — multivariable control. On the contrary to active damping scheme, PCi2uc-3L ensures higher quality of grid current (low THDi value). The methods were also compared with a predictive control algorithm of an AC/DC converter with L filter. The control performance was tested in the simulation model and validated experimentally by measurements.


This paper reports the effect of the irradiation of 50 MeV Li+3 ions on the thermomechanical properties of PMMA/PC blends. The radiation has been carried out at fluences of 1010 to 1012 ions/cm2 to observe any kind of chain scissoring/crosslinking occurring in the sample. The irradiated as well as the pristine samples have been characterized using X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), scanning electron microscopy (SEM) and dynamic mechanical analyzer (DMA) to study the induced changes in the structural, morphological and mechanical properties in blend films. The XRD results show an increase in the degree of crystallinity upon ion irradiation at low fluences (≤1011 ions/cm2) and a decrease in crystallinity at high fluences (>1011 ions/cm2), while the FTIR spectra show no appreciable change after irradiation. The mechanical characterization reveals that radiation significantly modifies the mechanical properties and the glass transition temperature of these polymeric blends.


Abstract:Alfred A. Knopf, Inc. is one of the most prestigious and influential publishing houses in the United States—and it was founded and has been largely staffed by Jews. These Knopf, Inc. staff members were regularly faced with the question of what kind of books about Jews should be published by a nonsectarian house like theirs, with famously high artistic and commercial standards. Thus the extensive Knopf, Inc. editorial records constitute an extraordinary archive reflecting the shaping of the "horizon of the publishable," in this case in terms of representations of Jews in America. Knopf, Inc. editors envisioned a specifically Jewish market for books, which they saw as one they could and should address. They understood that Jewish market not through data but through personal experience, and consequently published European Jewish literature in translation while remaining skeptical of works treating Jewish life in America. References to Alfred Knopf's Jewishness also served as a defense for authors accused of anti-Semitism, including H. L. Mencken and Raymond Chandler. As a whole, the case of Knopf, Inc. begins to answer the question of how and why it matters that throughout the twentieth century, Jews became increasingly prominent in the field of American publishing.


Submitted for the DAMOP18 Meeting of The American Physical Society Quantum-assisted dimension estimation of an interacting qubit system1 AKIRA SONE, PAOLA CAPPELLARO, Massachusetts Inst of Tech-MIT — The dimension estimation of an interacting qubit system is a crucial task since the dimension determines the quantum computation complexity or the precision in quantum sensing. Various protocols have been developed for dimension witnesses, which put a lower bound in the dimension by the measurement of the collective observables. However, their experiment implementation is practically demanding especially in multiple qubit systems. In our recent work [Phys. Rev. A 96, 062334 (2017)], we proposed a more practical strategy to estimate the dimension of an interacting qubit system, which relies on the coupling between a local quantum probe and the target system, instead of directly measuring the unknown target system. We assume that the interaction model is priorly given and all qubits are correlated with the probe through the time evolution. We employed realization theory to verify that the dimension of the target system can be exactly estimated from the model order of the system. We also derived the exact relation between dimension and model order for finite one-dimensional spin chain systems with nearest-neighboring interaction. 1U.S. Army Research Office through Grants No. W911NF-11-1-0400, W911NF15-1-0548 and the NSF PHY0551153 Akira Sone Massachusetts Inst of Tech-MIT Date submitted: 04 Jan 2018 Electronic form version 1.4


many discussions of the ongoing transformations of moving image culture focus either on the novelty of the latest equipment or on the synergistic power of industry — both technological and economic perspectives are perfectly valid, but nevertheless limit the scope of inquiry in problematic ways. Whereas the currently emerging configurations of audiovisualcy in the age of digital networks are often addressed in terms of absolute novelty and innovation I want to shift the focus slightly, articulating instead the new in terms of the old. 4 This essay therefore proposes the argument that it was within the Nouvelle Vague and the French film culture of the 1960s that the DVD was "invented". Obviously, this is a contrafactual argument, but if we understand the DVD as a discursive construction articulating a specific perspective on film, then the DVD simulates and emulates some key features of 1960s cinephilia that emerged within the context of the new waves. It is important to stress at the outset that I understand the Nouvelle Vague as a broad discursive movement encompassing all segments of the institution cinema rather than five auteur-directors — Truffaut, Godard, Chabrol, Rohmer and Rivette — and their respective films. By arguing for the continuing importance of film history and culture, I wish to underline the fact that technological as well as aesthetic transformations are central to our understanding of media culture.


In this study we investigated the adequacy of two non-orthogonal ECG leads from Holter recordings to provide reliable vectorcardiogram (VCG) parameters. The VCG loop was constructed using the QRS samples in a fixed-size window around the fiducial point. We developed an algorithm for fast approximation of the VCG loop, estimation of its area and calculation of relative VCG characteristics, which are expected to be minimally dependent on the patient individuality and the ECG recording conditions. Moreover, in order to obtain independent from the heart rate temporal QRS characteristics, we introduced a parameter for estimation of the differences of the interbeat RR intervals. The statistical assessment of the proposed VCG and RR interval parameters showed distinguishing distributions for N and PVC beats. The reliability for PVC detection of the extracted parameter set was estimated independently with two classification methods - a stepwise discriminant analysis and a decision-tree-like classification algorithm, using the publicly available MIT-BIH arrhythmia database. The accuracy achieved with the stepwise discriminant analysis presented sensitivity of 91% and specificity of 95.6%, while the decision-tree-like technique assured sensitivity of 93.3% and specificity of 94.6%. We suggested possibilities for accuracy improvement with adequate electrodes placement of the Holter leads, supplementary analysis of the type of the predominant beats in the reference VCG matrix and smaller step for VCG loop approximation.


Using case studies and research-based narratives to investigate the barriers facing developing enterprises in deprived communities, this book provides a toolkit for small business professionals and local authorities to revitalise a community-centered enterprise culture and reinvigorate disadvantaged groups.


A novel method was developed to produce a TiO2 film with circular pores on its surface.Macrospore structure can be obtained in the presence of two complexing agents of acetylacetone(acac) and diethanolamine(DEA) under a template-free condition.Notwithstanding,it has been found that irrespective of the kind of complexing agents,whether it is acac,or DEA,a common flat surface-formation process has been confirmed.In this account,acac or DEA added in the sols serve as stabilizers that impedes the hydrosis and polymerization among constituents during gel-forming reactions.But the situation has entirely changed when both acac and DEA were used as complexing agents.The hydrolysis is conducted under acidic conditions where a relatively narrow distribution of growing oligomers can be obtained.And the phase separation is driven by the reduction of miscibility between the polar solvent and polycondensed inorganic species.The phaseformation time would decline according the adding amount of DEA which triggers the process of hydrolysis under acidic conditions.The fluid phase of solvent mixture could oxidize and decompose to carbon dioxide which leaves numerous pores on the surface.The results show that the TiO2 film doped with two stabilizers exhibits superhydrophilic characteristic(6.5°) although it is not exposed to ultraviolet irradiation,comparing with flat ones(20° and 23°).Finally,the formation mechanism and the property-structure relationship were discussed in details.


The objective of this papers to describe the principles underlying coastal natural resources management, the norms and sanctions for their violations; to review and criticize legislation and policies related to regulation of coastal natural resources management, including Awig-awig in Pujut Subdistrict, Central Lombok regency, Indonesia. We used socio legal research types and focus group discussion with 20 respondents to establish the projects. The results indicated that coastal natural resources management is based on nine legal principles including principles of Benefit, Sustainability, Accessibility, Consensus, Protection/Environmental Arrangement, Common Interest, Supreme Awig-Awig, Legal Sync and Institution. The Jam, Local Implementing Authority (Awig-Awig) applies eleven principles: Local, Pancasila, Prioritizing Local Habits, Responsibility, Electing and Being Elected, Freedom of Argument, Compliance with Laws and Collective Agreements, Upholding Dignity of the Institute, Independence, Being Tiered, and Deliberation Priority principles. The norms in the of coastal natural resources management include norms of command, prohibition, and permissibility, and sanctions for violations in the form of dismiss on activities, and environmental restoration fines imposed. In conclusion, Awig-awig management of natural resources in Pujut Sub-district, Central Lombok Regency, does not conform to the principles in several related government laws. Keywords— coastal natural resource management; local wisdom; legal principles; awig-awig


Clinical information and cure results of 1 patient with chronic renal insufficiency combined with herpes zoster who had respiratory failure and received mechanical ventilation were analyzed retrospectively.For patients with senile chronic diseases,complication of virus infection can injure airway mucosa and pulmonary tissue and mechanical ventilation can aggravate airway or pulmonary tissue injury and cause subcutaneous emphysema.I believe that rich experience,correct and soft tracheal intubation method and reasonable setting of mechanical ventilation parameters can reduce airway or pulmonary tissue injury and reduce or prevent the occurrence of subcutaneous emphysema.


Purpose: Experimental radioimmunotherapy delivering absorbed doses of 2.5 to 10 Gy has been shown to cause growth retardation of tumors. The purpose of this study was to elucidate the sequential molecular and cellular events occurring in HeLa Hep2 cells exposed to such doses. Methods: Dose-response curves, activation of cell cycle checkpoints, and mitotic behavior were investigated in HeLa Hep2 cells following 2.5- to 10-Gy irradiation by carrying out 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays, Western blots, fluorescence-activated cell sorting analysis, and immunofluorescence stainings. Terminal deoxyribonucleotidyl transferase–mediated dUTP nick end labeling staining was used to detect apoptosis. Results: A G2-M arrest was shown by fluorescence-activated cell sorting analysis. p53 and p21 were found to be up-regulated but were not immediately related to the arrest. The G2-M arrest was transient and the cells reentered the cell cycle still containing unrepaired cellular damage. This premature entry caused an increase of anaphase bridges, lagging chromosomal material, and multipolar mitotic spindles as visualized by propidium iodide staining and immunofluorescence staining with α-tubulin and γ-tubulin antibodies. Furthermore, a dose-dependent significant increase in centrosome numbers from 12.6 ± 6.6% to 67 ± 5.3% was identified as well as a dose-dependent increase of polyploid cells from 2.8 ± 1.3% to 17.6 ± 2.1% with the highest absorbed dose of 10 Gy. These disturbances caused the cells to progress into mitotic catastrophe and a fraction of these dying cells showed apoptotic features as displayed by terminal deoxyribonucleotidyl transferase–mediated dUTP nick end labeling staining 5 to 7 days after irradiation. Conclusion: An absorbed dose of 2.5 to 10 Gy was shown to force HeLa Hep2 cells into mitotic catastrophe and delayed apoptosis. These might be important cell death mechanisms involved in tumor growth retardation following radioimmunotherapy of solid tumors.


Abstract Whilst service-user involvement in social work education generally is increasing, young people's involvement has, to date, been limited, and as such their voice is missing. Social media potentially offers mechanisms for addressing this, widening young people's participation. This article presents the findings of research, conducted in partnership with young people, exploring different types of social media currently available that may have the potential to be used in social work education to provide young people with a voice. Using methods developed from systematic review processes, the research set out to find, synthesise and collate these different resources. The findings suggest social media could provide an appropriate mechanism for enabling young people to share experiences relevant to social care. However, whilst some resources do exist, there are fewer than expected. A need is identified to develop new sustainable ways of enabling young people to have a voice. Current approaches were found to replicate barriers associated with service provision being compartmentalised, service led and framed by eligibility criteria. Recommendations are made for a united response from social work education institutions supporting approaches that give ownership to young people themselves whilst promoting sustainability and continuity.


Tilapia (O. niloticus) fish hatchery activity is a fishery business unit developed at the Klemunan Fish Fry Center (BBI), Blitar Regency. The purpose of this study was to determine the financial value and profit of the tilapia (O. niloticus) hatchery at the Klemunan Fish Fry Center (BBI), Blitar Regency. The research method used in this research is a survey research method with research data collection in 3 ways : active participation interviews, and observations. The financial analysis indicators analyzed are business profitability variables, R/C Ratio, Rentabilitas, Break Event Point (BEP) units and BEP sales. Based on the results of the financial analysis, the business profit value is Rp. 11.170.000,-, R/C Ratio at 8.81, BEP Unit at 58.6, BEP Sales Rp. 2,349,290, -, and business profitability of 49.9%, where the value of these indicators is very feasible because the numbers meet the criteria for a profitable business. So, from this research it can be concluded that based on business financial analysis which includes profitability analysis, R/C Ratio, BEP Unit, BEP Sales, and rantabilitas business, tilapia (O. niloticus) hatchery business activities at BBI Klemunan are very profitable and prospective to be developed.


This paper studied the effects of different light qualities on the growth and photosynthetic characteristics of Chinese chive(Allium tuberosum Rottl.ex Spr.).Taking'791 xuejiu'and'Zigenhong' Chinese chive as material,red light,blue light,red/blue(3/1)and red/blue(7/1)light generated by light-emitting diode were applied.And white light generated by fluorescent lamps was used as control.The results showed that the height,stem diameter,blade width and value of dry weight to fresh weight were the highest under red/blue(7/1)light.The contents of chlorophyll(a+b),carotenoid and chlorophyll(a/b)ratio were the highest under red light treatment.The photosynthetic rate(Pn),stomatal conductance(Gs),transpiration rate(E),maximal photochemical efficiency of PSⅡ(Fv/Fm)and Fv/Fo were the biggest under red/blue(7/1)light.Whereas intercellular CO2 concentration(Ci),quantum yield of PSⅡ(ФPSⅡ)and value of qP were the highest under blue light.It is conclude that the Pn of Chinese chive were significantly increased under red/blue(7/1)light,thus the plant growth and yield were also significantly increased.


As lithium insertion materials, manganese-based positive electrode materials are widely studying for the large-scale application, e.g., hybrid / pure electric vehicles. Among them, spinel-type LiMn2O4 and its derivatives have been extensively studied for this purpose. Recently, it has been revealed that Li2MnO3-based electrode materials show the more than 200 mAh/g of the rechargeable capacities after the electrochemical activation process with high voltage exposure. Although LiCrO2 is electrochemically inactive, chromium ion becomes electrochemically active in Li2MnO3-LiCrO2 system based on the Cr/Cr redox system [1] with cation migration process. In this paper, we report synthesis, crystal structures, and electrochemical activity of the Li2MnO3-LiCoO2-LiCrO2 system. Li[Li0.2Mn0.4Co0.4-xCrx]O2 was prepared by the solid-state method with acetate precursors. Figure 1 shows X-ray diffraction patterns of Li[Li0.2Mn0.4Co0.4xCrx]O2 (0.4 ≥ x ≥ 0). Single phase materials are obtained in the entire range. Lattice parameters linearly increase from ahex. = 2.825 and chex. = 14.16 A (x = 0) to ahex. = 2.867 and chex. = 14.31 A (x = 0.4) as the chromium content increases. Among the samples prepared, Li[Li0.2Mn0.4Co0.2Cr0.2]O2 shows the highest crystallinity with well defined diffraction lines. In addition, sharper (110)hex. Bragg reflection suggests that in-plane cation distribution is uniform within the individual particles. When a Li / Li[Li0.2Mn0.4Co0.2Cr0.2]O2 cell operated at a rate of 20 mA/g in the voltage range of 2.0 – 4.8 V, ca. 190 mAh/g of the rechargeable capacity is observed. Capacity retention is ca. 90 % after the 30 cycles. To study the reaction mechanism during the charging, X-ray absorption spectroscopy (XAS) is applied. Figures 2 and 3 show the XAS spectra of the Li[Li0.2Mn0.4Co0.2Cr0.2]O2 at Co and Cr K-edge, respectively. For the pristine sample, formal oxidation states of both Co and Cr are assigned into the trivalent states. A difference between Co and Cr ions is clearly observed for the 4.8 V charged state. For the Cr K-edge, pre-edge peak becomes visible clearly, whereas only minor change is observed for the Co K-edge. The increased pre-edge peak suggests the oxidation of Cr ions to Cr state. Moreover, EXAFS analysis revealed that Cr ion migration from the octahedral sites to the tetrahedral sites, which is consistent result with Li2MnO3LiCrO2 system by XAS at Cr L-edge [1]. It is noted that Cr / Cr redox reaction with the cation migration process seems to be partly reversible process. As shown in Figure 3, the intensity of the pre-edge peak is weakened after the discharging to the 2.0 V. From these results, we will discuss structural changes during the electrochemical cycling and the difference in the roles of Cr and Co ions in the Li2MnO3framework structures.


In zinc alloy die casting, the thin oxide layer generated on a mold surface causes soldering reactions, and the outer surface becomes coarser as the soldering proceeds. To minimize casting defects such as zinc deposits, we propose a surface modi cation of the mold to prevent soldering reactions. In this study, we observed the diffusion state of constituents generated between a molten zinc alloy (ZDC1) and the surface-modi ed mold material (maraging steel) using secondary ion mass spectrometry (SIMS). Furthermore, we analyzed the interfacial reaction layer between the surface-modi ed mold and the zinc deposits observed on the mold by transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDS), and considered the effect of surface modi cation on suppressing soldering reactions. [doi:10.2320/matertrans.M2017239]


INTRODUCTION The stream in the urban canopy layer is thought to be complicated. Therefore, modelling the vortexes in street canyons is an attractive subject for predicting the transport of motor vehicle exhaust gas. For predicting the concentration of air pollutants within a street canyon, one or twin vortex model is used in OSPM ( Hertel and Berkowicz, 1989). The vortex is created on the vertical cross-section of the street canyons ("vertical vortex"). The axis of rotation is along a street. It transports and mixes air pollutants emitted in the street canyon. However the OSPM is applicable to a 2-D street which has large distance between intersections. The effect of the transport of air pollutants through intersecting streets is not included in the model.


e16003 Background: There are limited data comparing first-line (1L) C versus IO in cisplatin-ineligible mUC patients. The primary evidence guiding treatment decisions was a May 2018 Food and Drug Administration (FDA) safety alert based on early review of two ongoing phase III trials, reporting shorter survival in PD-L1 negative patients receiving IO relative to chemotherapy. Final results from these trials are unknown and may not be applicable to a real-world cohort. Methods: We conducted a retrospective cohort study of mUC patients receiving 1L C or IO from January 1, 2011 to May 18, 2018 using the Flatiron Health electronic health record-derived database. The primary outcome was overall survival (OS) from start of 1L treatment to date of death. We compared 12- and 36-month OS, and hazard ratios before and after 12 months. Propensity score-based inverse probability of treatment weighting (IPTW) was used to address confounding in Kaplan-Meier (KM) and Cox multivariable regression model estimates of comparative-effectiveness. Results: Of 2,243 patients, 562 received IO and 1,681 received C. Baseline characteristics were balanced between groups, with few exceptions (Table). In the first 12 months, IO was associated with an increased hazard of death compared to C (HR 1.38, 95% CI 1.16-1.66). Among patients who survived one year, survival was improved with IO compared to C (HR 0.50, 95% CI 0.27-0.92). Conclusions: In routine clinical practice, 1L IO was associated with inferior 12-month OS relative to C, but superior OS beyond 12 months. Clinicians and patients should carefully consider how to balance the early benefit of C against the late benefit of IO. Currently pending trial results will contribute additional evidence to inform treatment decision making. [Table: see text]


This paper describes the application of VLSI (Very Large Scale Integrated) circuit in Artificial Intelligence (AI). VLSI is the inter-disciplinary science of utilizing advance semiconductor technology to create various functions of computer system. This manuscript addresses the close link of microelectronics and AI. By combining VLSI technology, a very powerful computer architecture confinement is possible.


Objective To evaluate the effect of pingyangmycin and dexamethasone infusing therapy on infantile hemangioma in oral and maxillofacial region. Methods 27 cases of infantile hemangioma in oral and maxillofacial region were treated with pingyangmycin and dexamethasone infusing therapy and were observed the curative effect. Results 22 cases were cured(81.5%), 5 cases were relieved(18.5%), and the total efficiency rate was 100%. There were no recurrence after 1-2 years. Conclusion Pingyangmycin and dexamethasone infusing therapy on infantile hemangioma in oral and maxillofacial region is a safe, convenient and efficient method.


In implementing the Chronic Care Model, the nurse has been indicated as key. The present study gives a theoretical reflection which aims to reflect on the integration of a theory of nursing into the Chronic Care Model. This reflection originates from a thesis project, in the context of a University Hospital which is a benchmark in the attendance of patients with diabetes, in specialized and hospital care. This proposal relates four elements of the model for organizing the nursing care for this clientele, associated with Horta's Basic Human Needs Theory. It is considered that using the Chronic Care Model, associated with Horta's Basic Human Needs Theory, can advance nursing practice with this clientele, evidencing the practice's elements and, consequently, evidencing the visibility of the nurse's competences and practice activities in care for the chronic illnesses. descriPtors: Nursing. Nursing theory. Chronic illness. Diabetes mellitus.


In 1997, Toyota introduced the first mass-produced hybrid electric vehicle, the Prius, in Japan. In 2003, they introduced the second generation of the Prius. The sales of the latter have been considerably stronger than those of the former. It is assumed that newspapers played an influential role in these increased sales. Consumer behavior theory recognizes that the media affects consumers. Thus, if there was a change in the ways newspapers portrayed Prius, this may have been a cause of the sales increase. The objective of this study is to analyze the ways newspapers reported on the vehicle in 1997-98 and 2003. Articles related to the Prius were collected from two leading newspapers in Japan. Content analysis was done on these articles to find the frequencies of selected features such as environmental, economic, driving, and others. Next, text analysis was performed to determine the attitudes that the articles showed toward those features. This study indicates that newspapers reported on the Prius as an expensive eco-car between1997-98, but in 2003, they had portrayed the vehicle as an eco-car with good driving quality. The reporting of driving quality improvement seems to play a role in bridging the price gap between Prius and the conventional vehicles. However, in their comparisons of the prices, the newspapers fail to recognize the reduction of air pollutants as a factor that justifies high cost, despite the fact that the newspapers did recognize the high environmental quality of the Prius. Introduction Emissions such as CO, NOx, SOx, HC, Particle Matters (PM), and Green House Gas (GHG) from automobiles are an environmental concern in many countries. Even though many efforts have taken place to reduce pollution, the automobile is definitely still a major source (Atkinson et al. 1991). Japan is no exception. About 20% of CO2 emissions in Japan are due to automobiles (Hayashida and Narusawa 1999). The Japanese government has tried to reduce CO2 emissions from automobiles since the Kyoto-protocol was passed in 1997. Car manufactures created hybrid electric vehicles in order to respond to pressure by environmentalists and regulations set by the Japanese government (Plunkett Research 2004, elect. comm.). The hybrid electric vehicle is a vehicle powered by a gasoline engine and an electric motor (Lave and MacLean 2001). Because it uses a non-polluting electric motor, it produces lower emissions than the conventional vehicles (Coffey and Sorenson 2001). Also it has a high fuel economy, because it converts extra energy into electricity and uses that electricity for the electric motor (Lave and MacLean 2001). Therefore it is considered "an environmentally less harmful vehicle" or "an eco-car" by the Japanese media (Mihori 2003). In 1997, Toyota introduced the first mass-produced hybrid electric vehicle, the Prius, in Japan. About five years later, they introduced the second generation of the hybrid Prius in 2003. They improved many features of the Prius when they developed the 2003 version. The fuel economy increased from 45 MPG to 55 MPG. The electric motor and the battery were improved to achieve better driving quality. Also, the design of the Prius 2003 is different from that of the Prius 1997, and incorporates better safety features. More importantly, under certain circumstances, Prius 2003 does not produce any pollutants. It is certified as a PZEV (Partial Zero Emission Vehicle), while Prius 1997 was categorized as a SULEV (Super Ultra Low Emission Vehicle). In spite of these improvements, the price of the vehicle remained the same (Mihori 2003). The most drastic change turned out to be the number of sales of the vehicles. Toyota received 3,500 orders in the first month after the release of the Prius 1997, and they sold about 16,000 Priuses in 1998 (Ikari 1999). For the second generation of the Prius, Toyota received over 18,000 orders in the first month, which was more than six times as much as expected. They project to sell over 70,000 Priuses in 2004 (Toyota 2003, elect. comm.). I believe that media has played a role in the increased sales of Prius. The function of mass media such as newspapers, TV, and radio is characterized as "mass production and dissemination of information to a mass audience" (Korobeinikov 1981). Media is a major source of product information to consumers (Iwasawa and Shimokawa 2000). However, the product information that consumers receive are mediated realities (Nimmo and Combs 1983). In the process of news making, the media does not publish 100% of the information they collect in a completely straightforward, objective manner. They select what information to use or ignore, and repeatedly edit that information. Therefore, the news articles that consumers view inevitably contain the media's subjective perspectives (Dahlgren 1981, Chaney 1981, Goto 1999). In this sense, consumer's recognition of the products is based on these mediated realities. Of course, media is not the only source of information. Even though the hybrid technology is a relatively new technology and many people may not have direct exposure to it, consumers can still receive information from salespersons, friends, and family members. Moreover, the decision-making process of consumers is recognized as a very complex system (Webb 1999, Olson and Reynolds 2001, Wagner 2003). After consumers obtain product information, they make comparisons with alternative choices. Then, they decide whether to buy the product based on individual perspectives such as preference, needs, and emotion and social perspectives such as family influences, cultural influences, and the media's point of view (Statt 1997, Gengler and Reynolds 2001). Thus, the role of the media is only a part of the complex structure of the producer-consumer relationship, and media analysis alone does not fully account for the increased sales of the Prius. However, the media nevertheless does have influence on the behavior of consumers. Therefore, it may be possible that the consumer behavior changes if the image of the Prius portrayed by media changes. Of the various types of media that exist, I chose to investigate the newspaper. In Japan there are approximately 650 newspaper subscriptions per 1,000 adults, which is the highest rate in the world (World Association of Newspaper 2003). Also survey results indicate that about 90% of Japanese people read a newspaper everyday or almost everyday (The Japan Newspaper Publishers and Editors Association 2003). Another survey shows that 83.8% of Japanese people consider the newspaper as a credible source of information (Dentsu Institute for Human Studies 2001). These numbers suggest that newspapers in Japan are recognized by consumers as essential and powerful sources of information. The objective of this study is to analyze the ways newspapers reported on the hybrid Prius in the years 1997-98 and 2003. Due to low emission rates of hybrid electric vehicles, they are considered as eco-cars. After the Japanese government set several regulations to control the emissions from automobiles and promote recycling, it is assumed that the environment had become a more eminent concern in society. Thus, consumers are more likely to buy a product if they recognize it as being eco-friendly. Therefore, my hypothesis is that newspapers in 2003 focused on the environmental aspects of the Prius more so than newspapers in 1997-98. Methods First, I selected two of the leading national newspapers in Japan as sources of information (Asahi shimbun and Yomiuri shimbun). I selected those newspapers because of the number of their daily circulations and the demography of the readers. According to the Yomiuri Shimbun (2003, elect. comm.), these two newspapers claim about 18 million daily subscriptions in total, and about 30-35% of households in Japan subscribe to either one or both newspapers. Yomiuri also claims that about 42% of Yomiuri subscribers and 37% of Asahi subscribers have an income of more than 80,000 dollars—and are thus financially capable of purchasing automobiles. I collected articles related to the Prius from online archives of past articles of these newspapers. The time period is from one month before the Prius came to the market and four months after the release. The Prius 1997 came to the market in December 1997, and the Prius 2003 came to the market in September 2003. Therefore, I looked for the articles from November 1997 to March 1998 and from August 2003 to December 2003. To gather the articles, I searched for articles containing the word "Prius." To ensure that I had gathered all articles about the Prius, I also searched for article with key words "Toyota" and "hybrid cars." Next, I divided the features of the Prius into four categories: 1) "environmental" (such as low emissions), 2) "economic" (such as price and fuel economy), 3) "driving" (such as acceleration and power), 4) "other features" (such as safety and design). According to a marketing book by Ikeo (1999), economic, driving, and other features are the main factors that customers are most likely to take into the consideration when they making a purchase. To these three, I added the environmental features, since a major selling point of Prius is its high environmental quality. From this point, I followed the principle of van Dijk's analysis of news comprehension. This analysis is designed to extract the basic presentation of elements of attentions and attitudes from the discourse. The attitudes reflected in the articles would indicate the meanings of the distribution of attention, and vice versa (van Dijk 1985). I conducted content analysis to find the frequency of references to selected features. Then, I conducted text analysis to classify the attitudes that the articles showed toward the selected features. For the content analysis, based on the method described by Riffe (1998), I counted any word related to the selected features that appeared in the articles, but only i


This paper describes the recent addition, characterization, and integration of emerging technologies for dynamic infrared scene projection at the US Army Aviation and Missile Command's Advanced Simulation Center. Infrared scene projection performs a vital role in the daily testing of tactical and theater missile systems within these Hardware- in-the-Loop (HWIL) laboratories. Topics covered within this paper include the addition and characterizations of new Honeywell and Santa Barbara Infrared emitter arrays, the integration and operation of the Honeywell and SBIR emitter array systems into a HWIL test, the development of high speed reduced-size IRSP drive electronics, the development of a NUC/characterization station, added software support, and the status of DMD-based infrared scene projector. Example imagery and test results from several of the projector systems are included within this paper.


In this study, we simulated the electron density disturbance at night in the bottom of the ionosphere caused by the electrostatic field in a thundercloud. The simulation was conducted using the charge of the thundercloud as the source, by incorporating a more up-to-date conductivity profile, and using the ion chemistry model for the lower ionosphere. The results revealed that a thundercloud charge of 30–100 C can cause a disturbance in the electron density in the lower ionosphere, decreasing to 40% of the original value or increasing to 160% of the original value. The electron density disturbance occurs mainly below an altitude of 80 km, and its peak is located at an altitude of 70 km, with a regional horizontal radius of about 50–75 km. The simulation results of this study improve the theory of Salem et al and extend the original one-dimensional model to three-dimensional space.


The invention relates to a method for interactively assisting a driver (10) of a vehicle (12) when operating the vehicle (10) by outputting a control support information (20, 22, 24, 26) in response to a driving situation and / or a driver's control behavior (10) and / or an identified state of the driver by means of sensors (10), wherein the output is visual, auditory and / or haptic. Furthermore, the method comprising the steps of acquiring data on a user behavior of the driver (10) and / or the driver (10) at least with respect to at least one other by the driver (10) state before the vehicle used (14) and providing a user profile on the basis of the acquired data in one of said vehicle (10) independent data network (10), wherein the outputting of the operation support information (20, 22, 24, 26) takes place additionally as a function of the user profile. The invention further relates to a system for carrying out such a method.


Background. Common variable immune deficiency (CVID) is a complicating comorbid background of COVID-19. Post-infectious immunity formation to SARS-CoV-2 during a pandemic is of particular relevance for such patients. Aim of the study - to present the features of the development of postinfectious humoral immune response in a patient with CVID. Material and methods. Patient K., 49 years old, the diagnosis of CVID verified at the age of 33, has been receiving regular replacement therapy with intravenous immunoglobulins for the last 10 years. After intrafamily contact and infection with SARS-CoV-2 due to the progressive deterioration of the clinical course of COVID-19, he was admitted to a monoinfection hospital. Results. During the treatment of the severe clinical case of COVID-19 a patient with CVID proved to be effective therapy combining anti-cytokine drugs and additional courses of replacement therapy with intravenous immunoglobulins. 6 weeks later from the development of the clinic, the patient was detected specific antibodies to SARS-CoV-2 antigens - IgM (CP 4.73) and IgG (43 BAU), in 4 months the corresponding parameters were 3.55 (CP IgM) and 487 BAU (CP IgG). Comparative analysis of immunophenotyping of the patient's B lymphocytes before the disease, during periods of early and late convalescence showed the dynamics of changes in the number of naive B-lymphocytes, unswitched and switched B-memory cells, plasmablasts, B-reg and B-lymphocytes expressing intercellular cooperation molecules. Conclusion. In the patient with CVID the development of a specific humoral immune response to SARS-CoV-2 after a COVID-19 infection is accompanied by an increase in the proportion of B-memory cells, increased maturation of B-lymphocytes, coordinated dynamics of B-cell suppression and activation parameters. Copyright © 2022 Authors. All rights reserved.


In Zhao Changqing's Ci Lyrics,he was adept in comparing beautiful women to fragrant flowers.Most of his works were dominated with a desolate and delicate mood with some few characterized with elegance,boldness and unconstrainedness or vulgarness and splendidness.As he was fond of suffixation of a nonsyllabic "r" and well versed in usage of modal particles and dialects,the language of his Ci Lyrics was natural,bright and beautiful,full of personal traits.


Commonly,mixed trigonometric polynomial systems are transformed into polynomial systems by variable substituting and adding some quadratic equations,and then solved by some solution method.However,transformation of a mixed trigonometric polynomial system into a polynomial system will increase the dimension of the system and hence induce extra computation.We consider solving the mixed trigonometric polynomial systems by homotopy method directly without transformation,thus the dimension of the system won't be increased and computational time can be saved.


Summary This single session conversation demonstrates a post-modern approach to counseling. Using constructionist concepts, the therapist and student collaborated to create a common language. Through this shared meaning making, the therapist witnessed the student retrieve a preferred story of her life. Furthermore, the retelling of this story has helped others to find their own forgotten narratives.


Recent mathematical advances in the context of rough volatility have highlighted interesting and intricate connections between path-dependent partial differential equations and backward stochastic partial differential equations. In this note, we make this link precise, identifying the slightly obscure random field introduced in [Pricing options under rough volatility with backward SPDEs, C. Bayer; J. Qiu and Y. Yao. SIFIN, 13(1), 179-212 (2022)] as a pathwise derivative of the value function.


In clinical trials, pharmaceutical companies test the efficacy and safety of a new drug for the treatment of a disease by comparing the results from a large number of diseased and healthy patients exposed to either the new drug, an existing drug that treats the disease, or a placebo. One primary concern is liver toxicity, which is usually diagnosed by blood analyte tests. Often, such signals of toxicity lead to the discontinuation of drug development or the withdrawal of the drug from the market. Early detection of liver toxicity can save lives and also save such companies billions of dollars. Existing approaches for detecting liver toxicity typically ignore correlations between blood analyte values, but in this work we present novel dissimilarity measures based on principal component analysis which can be used for detecting liver toxicity and identifying subpopulations who may be susceptible by taking into account the correlations structure of the data. Experimental results on real clinical trial data validate our approach.


This paper investigates the H2 model reduction problem for a class of linear discrete-time switched systems. By applying the piecewise Lyapunov functional approach and linear matrix inequality (LMI) technique, the exponential stability criterion of switched systems under average dwell-time is established. For particular original discrete-time switched systems, the corresponding reduction-order models are constructed so as to ensure the exponential stability of the error systems and to achieve prescribed H2 performance. A numerical example illustrates the effectiveness of the proposed methods.


【Objective】 The research was done to discuss the phylogeny of domestic bactrian camel in China and the relationship with wild bactrian camel.【Method】 The cytochrome b(Cytb) gene of mtDNA from 37 domestic bactrian camels samples was sequenced and analyzed with the available Cytb gene sequences of domestic bactrian camels and Camelus bactrianus ferus in GenBank.【Result】 The results showed that:14 mutations and 11 different haplotyes were found when Cytb gene partial sequence(1 024 bp) was analyzed,the nucleotide diversity(Pi),haplotype diversity(Hd) and average number of nucleotide differences(k) were 0.002 27±0.001 27,0.820±0.044 and 2.327 respectively,which showed a relatively rich genetic diversity existed in the domestic bactrian camel.With Camelus dromedarius as the outgroup,the phylogenetic tree was constructed by the NJ method.The Chinese domestic bactrian camels we researched had one type of maternal origin,which was of two lineages with wild bactrian camel,and the possibility of wild bactrian camel originating was also discussed.【Conclusion】 Our phylogenetic analysis revealed that the extant wild bactrian camel may not be the same subspecies at least in their maternal origins.


Volatile flavor compounds in mustard oil, wasabi, and "Chongcai" leaf mustard were investigated by SPME/GC/MS. In the three samples, 6,12,17 constituents were identified respectively; Allyl isothiocyanate was the main flavor compound, which accounted for 73.45%、64.25%、32.74% of total volatiles respectively. Furthermore, carbon disulfide accounted for 14.37%、25.40%、51.67% of total volatiles respectively.


ZnNb2O6-1.75TiO2 microwave dielectric ceramics with w(CuO)=2.00%,w(B2O3)=3.00% and w(SnO2)=0.15% additives were prepared at 880~975℃ through solid state reaction method.The mechanism of low-temperature sintering,the microwave dielectric properties and their application prepared ceramics in multi-layer chip capacitor were investigated.The results indicate that with increasing sintering temperature,the phase transforms from Zn2TiO4,Zn0.17Nb0.33Ti0.5O2,ZnNb2O6 to ZnTiNb2O8,the τf and er values decline while the Q·f value increases.But when t≥975 ℃,Q·f value decreases because of the abnormal crystal growth and crystal defects.The materials sintered at 950℃ for 4 h exhibit excellent dielectric properties:er=36.7,Q·f=18 172.2 GHz and τf=–22.6×10–6 ℃.The multi-layer chip capacitor made by this materials sintered at 950 ℃ shows good compatibility with Ag90Pd10 inner electrode and exhibit excellent properties and reliability(Res=0.3426Ω,tanδ=9×10–5).


Applying Hopkins's Theorem asserting that each unitary right Artinian ring is right Noetherian, G. Köthe and K. Shoda proved the following theorem (cf. Köthe [7], p. 360, Theorem 1 and p. 363, Theorem 5): If R is a unitary right Artinian ring, then the following statements hold: (i) Each nilpotent subring of R is contained in a maximal nilpotent subring of R. (ii) The intersection of all maximal nilpotent subrings of R is the maximal nilpotent twosided ideal of R. (iii) All maximal nilpotent subrings of R are conjugate.


The Control of White Root Rot of Apple Tree caused by Rosellinia Necatrix by Fluazinam and Prochloraz Mery Dafny-Yelin 1*, Shlomit Dor 1,2, Orly Mairesse 1, and Jehudith Moy 1. 1 Migal Galilee Technology Center, Northern Agriculture Research and Development, Kiryat Shmona, Israel. 2 Migal Galilee Technology Center, Kiryat Shmona, Israel. *Corresponding Author : Mery Dafny-Yelin, Migal Galilee Technology Center, Northern Agriculture Research and Development, Kiryat Shmona, Israel. E-mail: firstname.lastname@example.com, firstname.lastname@example.com Received date: March 19,2019 ;Accepted date : March 26,2019; Published date: April 05,2019. Citation: Mery Dafny-Yelin, Shlomit Dor, Orly Mairesse, Jehudith Moy, The Control of White Root Rot of Apple Tree caused by Rosellinia Necatrix by Fluazinam and prochloraz, J. Pesticides and bio fertilizers, Doi: http://dx.doi.org/ 10.31579/ 2578-8825.2019/048. Copyright : © 2019 Mery Dafny-Yelin. This is an open-access article distributed under the terms of The Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


A 3D real-scene copying device having high cost performance comprises a monocular multi-view stereoscopic vision sensor used for shooting a reconstructed object and a microprocessor used for performing image process and 3D real-scene copying on the reconstructed object; the monocular multi-vies stereoscopic vision sensor comprises a hopper-shaped mirror cavity, a shell, an objective table, a high-definition camera and a semi-spherical LED light source; the microprocessor comprises an image reading module, an image processing module, an image enhancing module, a three-dimensional point cloud obtaining module and a point cloud reconstructing module, the image reading module is used for reading an image, comprising five views, of the reconstructed object, the image processing module is used for segmenting the foreground of the reconstructed object from the image comprising the five views and performing rotation transformation and distortion correction on the image comprising the five views by means of a standardization result of the sensor, the image enhancing module is used for homogenizing the image brightness, in each view, of the reconstructed object, the three-dimensional point cloud obtaining module is used for extracting real three-dimensional coordinate values and color values of points on the surface of the reconstructed object, and the point cloud reconstructing module is used for performing three-dimensional reconstruction on point cloud data.


In his recent review, Tfelt-Hansen concludes that the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant has excellent tolerability but relatively low initial clinical efficacy. His conclusions about efficacy are based on group-level data from a meta-analysis of 4 published studies using 2-hour pain freedom and pain relief endpoints, with historical comparison to triptan data. We feel his conclusions about the efficacy of telcagepant may undervalue the potential usefulness of this new class of medication. First, we would point out that the endpoint in migraine trials is a responder rate analysis at 2 hours. A drug that has higher responder rates at a group level may not necessarily be better for an individual patient. Furthermore, patients take into account multiple attributes of drugs, including initial 2-hour efficacy, sustained efficacy, and tolerability, to determine which drug is most suitable for them. Second, despite the availability of treatments which are effective and well tolerated there remains a large unmet treatment need. Migraine is a common disease and the majority of patients self-medicate with over-the-counter general analgesics such as nonsteroidal anti-inflammatory drugs and acetaminophen. By the time patients seek help from their physicians, they have already failed over-thecounter drugs. Triptans are the most commonly prescribed migraine-specific drugs and are effective and well tolerated for many patients. Even so, in a recent study of 40,892 newly initiated triptan users, less than half refilled their initial prescription for the same triptan. Of the 22,031 patients who did not refill their initial prescription only 7% switched to another triptan while 34% switched to opioids, drugs which are associated with significant abuse liability and dependence issues. These data suggest that there is large unmet medical need that is not fulfilled by triptans. We believe that by targeting a different aspect of migraine pathophysiology, a CGRP receptor antagonist such as telcagepant has the potential to help address this large unmet medical need and provide additional treatment options for patients. Based on questionnaires about patient's historical treatment response in the phase 3 studies, we have found that the efficacy of telcagepant is not impacted by whether or not patients previously responded to triptans or <75% of time, to nonsteroidal antiinflammatory drugs or <75% of time, or to opioids or <75% of time. Third, Tfelt-Hansen suggests that results from the zolmitriptan comparison study may have been biased because only patients who had a poor response to triptans would be motivated to enroll. However, nearly half of the patients reported having a prior response to triptans in 75% or more of attacks. It is possible that these patients may be predisposed to have a better response to zolmitriptan, as was suggested in a post hoc analysis of data from the study, and therefore it is not clear in what direction potential biases may operate. We agree with Tfelt-Hansen that it would be preferable to compare a CGRP receptor antagonist with a triptan in patients who are triptan naïve. However, these patients are harder to recruit. Finally, we question Tfelt-Hansen's assertion that because CGRP is a key molecule in the pathophysiology of migraine then it necessarily follows that "one would thus expect a high efficacy in migraine of a potent CGRP antagonist such as telcagepant." It is increasingly recognized that multiple neurotransmitters and neuromediators are involved in migraine pathophysiology, and that migraine is the ultimate result of a complex neural network dysfunction that leads to an over-sensitive brain. Therefore, the expectation that any single drug would treat all patients is probably unrealistic. In conclusion, we would argue that the science behind the new class of the CGRP receptor antagonists is still in its infancy, and the relative advantages or disadvantages of this class over other treatments are still to be determined. It is, however, reasonable to expect that CGRP receptor Conflict of Interest: Dr. Bigal and Dr. Ho are full-time employees of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co. Inc., and own stock and stock options in Merck.


We propose to integrate weapon system features (such as weapon system manufacturer, deployment time and location, storage time and location, etc.) into a parameterized Cox-Weibull [1] reliability model via a neural network, like DeepSurv [2], to improve predictive maintenance. In parallel, we develop an alternative Bayesian model by parameterizing the Weibull parameters with a neural network and employing dropout methods such as Monte-Carlo (MC)-dropout for comparative purposes. Due to data collection procedures in weapon system testing we employ a novel interval-censored log-likelihood which incorporates Monte-Carlo Markov Chain (MCMC) [3] sampling of the Weibull parameters during gradient descent optimization. We compare classification metrics such as receiver operator curve (ROC), area under the curve (AUC), and F scores and show that our model generally outperforms traditional powerful models such as XGboost as well as the current standard conditional Weibull probability density estimation model.


Dismissal law protects those who are sometimes referred to as 'insiders', that is, workers whose employment is well protected. As a rule, there are four aspects to this protection. First, the law requires that there has to be good reason for any termination of the employment contract by the employer. Second, the termination is subject to procedural constraints ensuring that the reason for the dismissal is stated and that worker representatives, as provided for under the national system, are involved. Third, if the employer's action leads, in fact, to loss of employment, financial compensation must be paid. Finally, in the event of dismissal, workers must have access to a judicial body (or some other independent authority) which will scrutinise the employer's reason for the dismissal and, if the dismissal is found to be unfair, sanction the employer. To differing degrees, it is these four elements which are now under challenge.


A chec klist of the Melastomataceae of Equatorial Guinea is presented with 57 taxa. Three species were accepted based only on literature records, their distribution area strongly suggests their presence in Equatorial Guinea. Six species are known from Annobon, 23 from Bioko and 49 from Rio Muni. Best-represented genera are Memecylon (10), Calvoa (10) and Tristemma (7). Twenty-six taxa are newly recorded for the country. Heterotis obamae Lejoly & Lisowski is set in synonymy with the previously described Heterotis arenaria Jacq.-Fel.


Two-dimensional electrophoresis(2-DE) is an important technique in proteomics research.The 2-DE system for proteome of Monascus ruber was established by comparing and analyzing the infection caused by different kinds of mediums,lysis buffer and the condition of rehydration.By cultivating the Monascus ruber with YES for 6 days,extracting total protein by TCA-acetone,lysis buffer with 8 mol/L urea,2 mol/L thiourea,4 % CHAPS,1 % DTT and 2 % Bio-lyte,an ideal 2-DE map with higher resolution and better legibility was obtained,which laid a foundation for the further studies on proteome of Monascus ruber.


There has been a growing interest in the environmental impact of aviation, both in terms of noise and aircraft engine emissions. Discussions have included both mitigation measures and methods of internalisation of these environmental costs also described as the principle of polluter pays. This paper focuses on CO2 emissions from aircraft engines, which have both local and climate change implications, and where the emphasis of most recent discussions has centred. These have taken place at an international, regional and local level.


Two anaerobic rumen fungi Piromyces sp. OTS3 and Neocallimastix sp. OTS4 isolated from a goat were tested for their ability to degrade urea. The fungal cultures were not contaminated with mycoplasmas. Replacement of the trypticase and yeast extract components of Medium 10 with urea decreased the growth of Piromyces sp. OTS3 the same as the growth in Medium 10 without trypticase and yeast extract. Urea degradation was not demonstrated in the cultures of Piromyces sp. OTS3 or Neocallimastix sp. OTS4. Fungal growth and urea concentration in the medium were not correlated for Piromyces sp. OTS3 (r=0.052) or Necallimastix sp. OTS 4(r=0.324). However, fungal growth and ammonia concentration in the medium were correlated for Piromyces sp. OTS3 (r=-0.838) and Neocallimastix sp. OTS4 (r=-0.889). No ammonia was produced from urea by any washed cells of Piromyces sp. OTS3. Piromyces sp. OTS3 homogenates did not degrade urea and did not produce ammonia from urea. These results suggest that Piromyces sp. OTS 3 and Neocallimastix sp. OTS4 have no ureolytic activity. Anim. Sci. Technol. (Jpn.) 65 (10): 950-955, 1994


The upper reaches of the Songhuajiang River is one of the important area in agricultural comprehensive development of the Northeast China.Also superiority for developing freshwater fisheries are physical resources from watersk organisms and climate.According to the results of the investigations on fishery resources in the upper reaches of the Songhuajiang River in recent years, this paper bases the ways of rational exploitation and use on fishery resources superiority in this area,i.e.rational use of natural fish resources;artifical enhacement of fish resources and culture of mediumsized and large waters;using the river waters to develop river course fishery;using to cold water resources to artifical enhacement and culture of the cold water fish;set up compound ecofishery model of the waters and fishery development in lakes returned from yield.


A modified hydrogen-reduction method yielded accurate values for the t otal oxygen content of several plain carbon steels, including steels that contained small amounts of alumina and silica, but yielded low results when larger amounts of alumina were present. The method was not applicable to the det ermination of the oxygen content of open-hearth iron because of inability to separa te surface and body oxygen in this m aterial. CONTENTS P age


This thesis examines the role of building morphology and street networks in shaping street activity and transformations in the historical built form. The core inquiry applies a configurational analysis to the street, viewing it as a complex entity which interfaces with both buildings and the urban street network. The research is founded on the identification of two theoretical and methodological gaps in the canon of urban design: how generic building morphology properties relate to street liveability; and, how urban diversity emerges as the result of diachronic processes. The thesis looks at architecture beyond function, geometry and aesthetics, focusing on the urban street as a generator for social contact. Building on space syntax theory, it seeks to advance the concept of the 'virtual community', proposing that encounter and co-presence patterns are the product of both city-wide connections and local building morphology. In order to study building-street relations in terms of the virtual community the thesis has developed a series of specialised techniques to describe and analyse the synchronic and diachronic aspects of space. The thesis is innovative in integrating space syntax and Conzenian methods to better examine the micromorphology of the street interface configurationally and typologically, capturing the changing nature of built form and building use over time. This methodology is applied to the study of two contrasting urban areas: Islington, London and West Village, Manhattan. Both possess similar building morphologies that have sustained street liveability and diversity over centuries. The results show how urban change and diversity are affected by diachronic processes working with the synchronic structure of the everyday city. The thesis asserts that urban configuration and built form together play an essential role in shaping the character of the 'virtual community' as well as the potential for street life itself.


Proc Amer Assoc Cancer Res, Volume 46, 2005

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One of the most critical issues to be solved in regard to cancer chemotherapy is establishment of ways to predict efficacy of anti-cancer drugs for individual patients. Development of the ABL-selective tyrosine kinase inhibitor imanitib mesylate (IM) (Glivec; Novartis Pharmaceuticals, Basel, Switzerland) was an important advance in the management of chronic myeloid leukemia (CML). IM is highly effective in the first line therapy of CML without severe adverse effects. However, it remains unknown whether IM cures CML or not, and other therapeutic modalities like stem cell transplantation sometimes become necessary. To develop a prediction system based on expression of specific genes, we initially analyzed expression profiles of mononuclear cells from 22 CML patients who had previously failed in interferon-alfa therapy. cDNA microarrays representing 23,040 genes identified 79 genes that were expressed differentially between the responders and the non-responders to IM using random permutation method. On the basis of expression patterns of 15 out of these genes, we developed a prediction system that could clearly separate the responders from the non-responders. We further verified this prediction system by a cDNA microarray using 42 additional CML patients who would receive IM as monotherapy. Of 40 patients who attained major cytogenetic response (MCR) by 6 months after treatment of IM, 38 (95%) had been predicted as the responder by the prediction system, whereas two patients whose effect was less than MCR had been predicted as the non-responder. Hence, selection of the CML patients prior to the treatment of IM by our prediction system could increase the efficiency of the protocol up to nearly 100%. These results suggest that the chemosensitivity to anti-cancer drugs can be predicted by gene expression levels of a set of genes, and may eventually, lead to the achievement of "personalized therapy" for this treatment.


Abstract:This essay investigates how eruptive interpersonal forms of state-sanctioned racial violence secure and enable insidious forms of "slow violence" and environmental racism in Héctor Tobar's The Tatt ooed Soldier. The novel theorizes ways in which spectacular military violence and attritional environmental violence work in tandem to reify the lasting, deleterious effects of US imperial power at both the periphery and core of US empire. I argue that these different modes of violence are legitimated and enacted within the novel through similar rhetorics of state corporeality, environmental cleanliness, and purity in both Guatemala and the United States. The metaphors of bodily purity and hygiene in the novel highlight the shared genealogy of the systems of oppression targeting racial minorities, and they create environmental degradation in both countries. Understanding the role of environmental violence—both the violence done to physical environments and the violence emanating from state manipulation of those environments—suggests how studying armed conflict's environmental ramifications can lead to broader theorizations of social justice and oppression.


This article devises a road ahead for future studies of gender mainstreaming of Disaster Risk Reduction (DRR) processes. In comparison to other fields, DRR processes lag behind in implementing a ge ...


Vermicomposting technology is one of the best options available for the treatment of organics-rich solid wastes. In which earth worm converts biodegradable garbage into high quality manure and plays a key role in soil biology and they serve as versatile natural bioreactors to harness energy and destroy soil pathogens. The worms feed voraciously on all biodegradable wastes. There is an instance of chemical toxicity among non target organisms like earthworms etc, in agricultural lands due to pollution of chemical companies and factories. In the present investigation vermicomposting ability of earthworms Eudrilus eugeniae were measured experimentally by exposing in moist leaf litter with Aluminium. The morphological changes observed during the exposure of animals were observed in laboratory conditions and appears to impair the different stages of reproductive cycle of the worms thereby resulting in the onset of reduced vermicomposting ability of the earthworm.


The model-based approach to fault detection and isolation in automated process has received considerable attention during the past two decades. One of the approaches to facilitate fault isolation is to design a structured residual set. The term structured here means that each residual is designed to be sensitive to a certain group of faults and insensitive to others. However, despite this issue has been recognised for a long time, the problem of designing such residuals is not completely solved. In the context of linear static systems, this paper proposes a new method for sensor network design respecting some sensor failure detectability and isolability requirements.


RDMA (Remote Direct Memory Access) provides memory semantics to access the remote memory directly bypassing remote CPUs. It can provide low latency and high throughput that can benefit many data center applications. Though a lot of efforts had been made in the literature, this paper tries to find more opportunities to boost the performance of memory semantic operations in the RDMA network. Similar to the optimizations for local memory operations, we find that the performance can be improved in the RDMA network after considering the vector IO mechanism, the performance asymmetry between sequential and random access, IO consolidation, NUMA effects, as well as the atomic operations (such as compare and swap) provided by the underlying hardware. We have done a comprehensive empirical study on the influences from these factors for the memory semantic operations in RDMA network and provide guidelines to improve applications. Experimental results show that four typical applications, disaggregated hashtable, distributed shuffle, distributed join, and distributed log are improved by 2.7×/5.8×/5.3×/9.1× respectively after considering memory semantics related optimizations.


The purpose of this plan is to describe the organization and methodology for the certification of radioactive mixed waste (RMW) handled in the Hazardous Waste Handling Facility at Lawrence Berkeley Laboratory (LBL). RMW is low-level radioactive waste (LLW) or transuranic (TRU) waste that is co-contaminated with dangerous waste as defined in the Westinghouse Hanford Company (WHC) Solid Waste Acceptance Criteria (WAC) and the Washington State Dangerous Waste Regulations, 173-303-040 (18). This waste is to be transferred to the Hanford Site Central Waste Complex and Burial Grounds in Hanford, Washington. This plan incorporates the applicable elements of waste reduction, which include both up-front minimization and end-product treatment to reduce the volume and toxicity of the waste; segregation of the waste as it applies to certification; an executive summary of the Waste Management Quality Assurance Implementing Management Plan (QAIMP) for the HWHF (Section 4); and a list of the current and planned implementing procedures used in waste certification.