Sectional surfaces of the lithium-drifted silicon detector are observed using the scanning electron microscope (SEM). Cyclic striation lines are observed in the lithium-drifted region of a detector made from a large-diameter silicon ingot. This is confirmed to be due to a cyclic fluctuation of donor impurity caused by a cyclic change of temperature during floating-zone processing. These materials are judged to be unsuitable for detector application. >


In this paper a Genetic Algorithm developed by Duan et al (1992) has been used to evaluate and modify the structure of "Tank Model" for two different basins in the northeastern Brazil for daily and monthly data. The algorithm entitled "Shuffled Complex Evolution - SCE" is based on the formulation and natural evolution of multiple initial complexes (parameter sets). It combines the power of the Simplex Method with the concepts of controlled random search and extraction of genetic operators generating shuffled complexes of the parameter values. The Tank Model With its structure consisting of a set of linear reservoirs in series or parallel with side and bottom passages has been found to give good results for the semi-arid basins in the northeast of Brazil. The application of the genetic algorithm resulted in three different versions of the Tank Model for humid and semi-arid conditions with monthly and daily data.


Since World War II there has been a revolution in contraceptive methods. A steady progression of sterilization operations due to their relative simplicity has occurred particularly in third world countries. Attitudes surrounding legalization of this operation differ greatly around the world reflecting ethical cultural and economic traditions of each country. In many nations of Europe this type of intervention is fully authorized but in France the situation remains obscure and ambiguous. It is the law and not the desire of the patient that entitles a doctor to perform this type of intervention sometimes deemed to be of a mutilating character. France did vote for the resolution by the European Commission on November 14 1975 declaring that voluntary sterilization should be made universally possible and considered a medical act. Until 1983 when new ethics directives were issued for doctors in France sterilization could not be performed for contraceptive purposes alone. Today around 25000 sterilizations are estimated to be performed each year in France. The new directives specify that both masculine and feminine sterilizations are mutilating interventions whose psychological and moral consequences are unpredictable and may only be practiced when very serious motives are involved placing squarely the responsibility on the doctor for taking these motives into account. Many consider it unnecessary for the legislators to intervene in order to clarify the legal status of voluntary sterilization. No penal action has been taken for the last 50 years and only a few civil action suits show that this type of intervention is largely tolerated. However in order to alleviate the problems perceived by doctors concerning insurance matters it is desirable that voluntary sterilization is finally recognized as being merely a medical intervention as propounded by the European Council.


A coding/transmitter device (11) includes a broadcasting module (12) in order to broadcast television to a plurality of STB receiver/decoder devices (15) via an IP/Internet network (14), so that the clients-subscribers are provided with a first UDP stream and a second UDP stream which includes identification data associated with data packets transmitted within the first UDP stream in order to provide functionalities such as reorganisation of packets, detection of losses, requests for retransmission etc. without adding headers according to the RTP protocol, but with a reliability and capability of inserting additional data comparable to that provided by the RTP protocol.


Introduction At present, there are no strong predictors, nor a useful scoring system, that clearly identifies patients at risk for anastomotic leakage. Aim This study aimed to investigate a new method that assesses this risk by monitoring levels of neopterin, tryptophan, and kynurenine, in bodily fluids. Material and methods This prospective study included patients who underwent elective rectal resection for carcinoma. The basic condition for inclusion was rectal anastomosis using the double-stapling technique. Preoperative levels of neopterin, tryptophan, kynurenine, and their ratios, were assessed with blood and urine samples. These levels were then monitored for 6 postoperative days in venous blood, urine, and abdominal drainage fluid. Results A total of 42 patients were enrolled in the study. Thirty-six patients underwent a laparoscopic resection and 6 patients had an open procedure. No differences were found among neopterin, tryptophan, and kynurenine serum levels. However, the groups were observed to have significant differences in the urinary neopterin/creatinine ratio: the preoperative neopterin/creatinine ratio was 139.5 μmol/mol in the group with leakage, vs 114.8 μmol/mol in the group without complications, p = 0.037. The same results were observed during the postoperative period, p = 0.012. Additionally, the group with complications had a higher mean value of neopterin in drainage fluid, p = 0.048. Conclusions Our study demonstrated that high preoperative levels of urinary neopterin could be interpreted as a risk for anastomotic leakage. Moreover, pathological levels of neopterin in urine and abdominal drainage fluid could be useful for early identification of anastomotic leakage during the postoperative period prior to its clinical development.


The electroencephalogram (EEG) is a recording of the electrical activity of the brain from the scalp. The recorded waveforms reflect the cortical electrical activity. EEG activity is very small, measured in microvolts (μV). EEG is a non-invasive method to record electrical activity of the brain. Most commonly it is used to identify the type and location of the abnormal activity in the brain during a seizure. It is also used to analyze sleep disorders such as encephalitis and brain dead. The aim of this design aspect is to study and capture the signals generated in the brain to diagnose spikes which are used to identify epilepsy. Here we analyze the signals produced from the brain by signal conditioning and amplifying so that these signals can be displayed on a monitor which gives a vivid picture of the artifact in the EEG signal. These amplified signals are parallel applied to the Arduino which on detection of spike produces an output signal which can be viewed using an LED. Here we use three copper surface electrodes two placed on the neck and the other on ear which is used as a reference and thus we acquire the data from these electrodes.


The constitution of Bangladesh aims to ensure quality education for all children. Attending school regularly and completing the cycle is a pre-condition of quality education. This qualitative research was conducted to obtain insights into current practice on community involvement for regular student attendance and reducing dropout in rural Government Primary Schools (GPS) in Bangladesh as well as challenges and possible initiatives. Data were analyzed thematically after conducting five semi-structured interviews with Upazila Education Officers, Assistant Upazila Education Officers, head teachers, and School Managing Committee chairmen; two focus group discussions with assistant teachers and community members of two rural GPS; and school observation. We find that various local and school committees and associations were not performing their assigned and defined roles. Physical home visits were effective but not performed on a regular basis. Mother gatherings were to some extent helpful with the possibility of broadening their scope, but uthan boithok (local gatherings in common spaces) were totally absent. Poverty and lack of awareness about formal education, the tendency of educated families to live in cities and town, negative perceptions of communities about government organizations, the unexpected attitudes of teachers towards rural guardians, and a lack of about the importance of community involvement were the main challenges hindering community contribution to regular student attendance and reducing dropout. To mitigate these challenges, we recommend robust educational leadership, where head teachers as leaders take the required initiatives by raising awareness through collaborations with the local community. This research contributes to ensuring quality education by discussing possible initiatives involving the community to promote regular student attendance and reducing dropout in rural GPS.


Transmitters employed in modern wireless communication systems generally incur in power and carrier transients. With the aim of limiting possible interference to other equipment operating in adjacent channels, the European standard on electromagnetic compatibility and radio spectrum matters imposes upper bounds on transmitter attack time. The standard also recommends a suitable test setup, in which a great number of instruments are involved. The authors propose an alternative digital-signal processing method for transmitter attack time measurements, based on time-frequency representations. The method simultaneously measures both power and frequency transients, and requires only a data acquisition system and a processing unit. Moreover, thanks to the use of band-pass sampling strategies already proposed by the authors, just a few thousand samples have to be acquired to measure the attack time. Optimal TFR parameter combinations are singled out through experimental tests on emulated signals, and examples of the application of the proposed method on actual RF transmitters are provided


We want to open this discussion by repeating an earlier argument (Radovic 2008b) that there is a need to revisit World City Hypothesis (Friedmann, 1986). We see that as important in the context of the Conference on Degrowth, Ecological Sustainability and Social Equity, as the idea of "world city" implies a certain (kind of) quality, and the concept of degrowth and the idea(l) of sustainable development are both about a necessity to redefine the very criteria which frame our understanding of progress. Cities offer an important arena for all developments related to sustainable future.


The paper discusses the reasons for establishing wetland parks and describes the characteristics of wetland parks. Major problems were identified in planning, establishment and management of wetland parks, such as disorder, simplification, garden-like, and unclear institutional system of establishment and management. The author made suggestions for healthy development of wetland parks in China.


The paper describes the semantics of the preposition "по", which is the most ambiguous and common preposition of the modern Russian language. Thus, it reveals a tendency to blurred semantics, which makes a deeper consideration of this problem quite relevant. The author analyzed scientific literature on this issue and built a classification its meanings. The semantic analysis and statistical calculations were conducted in the basis of scientific texts. The preposition proved to be used mostly in the meaning of adverbial modifier of manner "to act in accordance with something, on the basis of something". Within this meaning, a number of semantic shades were highlighted: to be defined according to some parameter; act on the basis of certain data, facts; act in accordance with a certain way of organizing the phenomenon; act on the basis of someone's will (decision), desire; act in accordance with certain official documents and procedures; to be defined according to a certain naming method; to be defined on the basis of some measurement method. The analysis can improve the semantic structure of the preposition "по" in modern Russian.


How children learn grammar has been one of the most long-standing questions in cognitive psychology. After decades of both naturalistic and experimental child language study, two dominant approaches have emerged: generativist and constructivist. The generativist approach argues children reach adult-like productivity with the help of innate Universal Grammar, while the constructivist approach argues that children's grammar learning is incremental and input-based. However, the research field has been dominated by research on verbs and/or morphologically poor languages, such as English. The current thesis addresses these gaps in research by testing children's knowledge of the full noun morphology system in Lithuanian, a highly morphologically complex language. Three studies are reported in this thesis. The naturalistic speech study found that the child's overall low error rate hid "pockets" of high error rates in mediumfrequency contexts, and that the child was likely to use a high frequency surface form when she produced an erroneous form. There was also some evidence that the child was significantly less flexible in her use of noun cases than her mother. The second study was an elicited production study testing children's ability to produce different cases of familiar nouns. In addition to a relatively high error rate and a tendency to "default" to a high frequency morpheme, significant surface form and phonological neighbourhood density effects were found. Finally, the third study, an elicited production study using novel nouns, tested children's productions of novel noun forms. The results echoed the findings of the familiar noun elicitation experiment. The significant effects of age and phonological neighbourhood density provided evidence for an incremental analogy forming process based on similar, previously acquired items. Together, the multi-methodological group of studies offer a coherent argument against the idea of early full productivity favoured by the generativist approach and support the input-based constructivist approach. However, certain findings, such as the relatively good performance with low frequency cases in the naturalistic speech study, and inconsistent age effects across the elicited production experiments, also challenge current constructivist theories of complex morphology acquisition.


An additional reference is needed in the article Cytoprophet: a Cytoscape plug-in for protein and domain interaction networks inference. We include this reference as a matter of addendum.

Contact: firstname.lastname@example.com


set at 300,000 (a remarkably low figure for his day) is reduced by Meiggs to 180,000, on the strength of General Maurice's compelling logistic calculations. He might have applied his editorial shears more ruthlessly to Bury's Hollywood picture of the battle of Himera, which follows too closely Diodorus' make-up piece. The long section on the Athenian Empire and on the Peloponnesian War also stands substantially unchanged in the new edition; but in the light of much new or reinterpreted epigraphic evidence Meiggs has skilfully elucidated the financial history of Athens and clarified the problems of the allies' tribute. In reference to the first encounter of the naval campaign of 459 B.C. he tacitly and tactfully corrects Bury, who had followed Jowett in rendering evucwv KoplvOioi (Thucyd. i. 105. 1) by 'the Athenians gained the advantage'. With the advent of the reputedly dismal fourth century Bury's interest did not flag, and Meiggs's notes and text-alterations are correspondingly few. One would have liked a mention of the discussions on a Koivf/ elprjvrj, backed by sanctions, in the mid-century peace-congresses, and a fuller reconstruction of Philip's Hellenic Confederacy. An authoritative judgement on Alexander cannot be formed without some study of the Hellenistic period. Bury therefore did not make any full and critical pronouncement on the king's character and achievements, and Meiggs's chief task has been to correlate Bury's version with the masterly reconstruction by Tarn. His sceptical faculty here stands him in good stead. He has doubts about Alexander's vision of the Brotherhood of Man and of a political purpose (to legalize his usurpation of absolute power) in the king's demand for deification ; but he cogently supports Tarn's strong case against Alexander's alleged intention of conquering the West. ev Trapepyco.—In the text (p. 115) the date for the foundation of Naucratis is given as c. 620, in the notes it is c. 610. In the text (p. 427) Meiggs accepts Bury's date, c. 424, for the Xenophontic AO-qvalcov IJoXireia, but in the notes he favours c. 420. And the form 'Dracon' is neither Greek nor Latin nor English. Given a free hand by the printer, Meiggs might with advantage have omitted some of the irrelevant coin-illustrations which litter Bury's pages; also the view of the Mycenaean road on p. 30 and the bas-relief of a Greek trireme on p. 264, which are insufficiently distinct. But among his new pieces it is nice to find an unusually good view of the temple at Segesta, the Ostia head of Themistocles, and authentic portraits of Plato and Aristotle. M. CARY


This contribution deals with a new idea of how to create evolutionary algorithms by means of symbolic regression and Analytic Programming. The motivation was not only to tune some existing algorithms to their better performance, but also to find a new robust evolutionary algorithm. In this study operators of Differential Evolution (DE), SelfOrganizing Migrating Algortithm (SOMA), Hill Climbing (HC) and Simulated Annealing (SA) were used during a process of Analytic Programming. The results showed that AP was able to find successful as well as the original DE or SOMA. The cost function includes not only success in unimodal and multimodal benchmark function but also rules concerned to cost function evaluations. Results were tested on 16 benchmark functions in 2D, 20 D and 100 dimensional versions, i.e. 192 test, each was 100 times repeated and each of 100 repetitions has around 200 000 cost function evaluations. The results are presented in tabular and graphic form.


As the development of deep water production system becomes more common, cost effective maintenance through subsea intervention becomes an increasingly important design goal. One method of accomplishing this goal is the use of ROV replaceable control valves. These valves offer an attractive alternative to permanently installed subsea control valves by providing readily replaceable/interchangeable control components for a variety of applications. As part of an ongoing developmental program, a prototype 10,000 psi ball valve has been designed and tested. The results of these tests have shown the effectiveness of the overall design and the feasibility of developing additional valve types.


Background: Donor T cells specific for minor histocompatibility (H) antigens can deliver potent, selective anti-leukemic effects after allogeneic HCT when the antigen is negligibly or not expressed by non-hematopoietic tissues, not present in the donor, and expressed by the recipient. We reported a new minor H antigen-directed T-cell therapy that can be deployed after HCT to manage persistent or recurrent measurable residual hematologic malignancies or overt relapse (Blood 2018;131(1):108). We developed a transgene with 4 components: 1) a high-affinity T-cell receptor (TCR) specific for the hematopoietic-restricted minor H antigen, HA-1 that is presented on HLA-A*02:01; 2) a CD8 co-receptor to enhance function of the class I-restricted TCR in CD4+ T cells so they promote cytotoxic CD8+ T cell function and survival; 3) an inducible caspase-9 safety switch, which can be triggered by the drug rimiducid in case of in vivo toxicity; and 4) a CD34-CD20 epitope to facilitate selection of the engineered product during manufacturing and track HA-1 TCR T cells in the recipient. The 21-day manufacturing process entails CD45RA+ naïve T cell depletion (minimizes the risk of GvHD), and subsequent CD4+ and CD8+ separation (provides a consistent 1:1 CD4:CD8 ratio). The separate cultures are transduced with the lentivirus construct iCasp9-HA1-TCR2-RQR-CD8, expanded, and selected using the CD34 marker to ensure removal of untransduced T cells.
 Study Design and Methods: The single-center phase I trial (NCT03326921) evaluates the feasibility and safety of infusion of HA-1 TCR T-cell immunotherapy. Primary end points are 1) Feasibility of manufacturing and administering HA-1 TCR CD8+ and CD4+ memory T cells and 2) Dose-limiting toxicity of HA-1 TCR T cells. Major inclusion criteria are: HLA-A*02:01-positive, HA-1-positive patients who underwent HCT for acute leukemia, myelodysplastic syndrome, BPDCN, CML, CMML or JMML from a HLA-A*-02:01+/HA-1-negative donor or HLA-A*02:01-negative haploidentical or mismatched donor (excluding umbilical cord). HA-1 genotype screening is performed on patient and donor blood, hair follicle or cheek swab samples shipped to Fred Hutchinson Cancer Research Center. To be eligible for treatment, patients must develop measurable residual disease or overt relapse after HCT but may receive other standard or investigational therapies prior to treatment with HA-1 TCR T-cell immunotherapy if clinically indicated. Some systemic immunosuppression may be continued, but prior grade IV acute GVHD and prior severe chronic GVHD are key exclusions. Two groups, <16 and ≥16 years, will be treated at dose levels ranging from 3 x 106 to30 x 106 cells/kg, in cohorts of 3-6 subjects, up to approximately 24 subjects in total. Fludarabine lymphodepletion will be used in most subjects, followed by a single T-cell infusion, with an option for a subsequent infusion(s) if the subject demonstrates an initial response without severe toxicity. Bone marrow aspirations are performed prior to T-cell infusion and at several time points following infusion.
 Recruitment and Patient Characteristics: To date, 3 subjects have been treated on the phase I clinical trial and received a total of 5 infusions (Table 1). HA-1 TCR T cell persistence in blood and bone marrow has been documented from >3 months to >13 months. Clear in vivo anti-leukemic activity was observed at the first dose level, including in a subject with aggressive, highly refractory T-ALL and early post-HCT relapse.
 Outlook: Minor H antigen-specific T-cell immunotherapy may offer effective management of post-HCT relapse while avoiding GvHD and other off-target effects. Due to population genetics of HA-1 and HLA-A*02:01, HA-1 TCR T-cell immunotherapy is applicable to 10-15% of HCT recipients with various hematological malignancies. The ongoing phase I trial is actively recruiting patients. Development of T-cell immunotherapy targeting other minor H antigen/HLA combinations is also underway to increase the broad applicability of minor H antigen-targeted T-cell immunotherapy.

 Krakow: HighPass Bio: Research Funding. Cunningham:HighPass Bio: Research Funding. Vartanian:HighPass Bio: Research Funding. Bleakley:HighPass Bio: Current equity holder in private company, Membership on an entity's Board of Directors or advisory committees, Patents & Royalties, Research Funding.


discussing possible cognitive, sensory-perceptual and motor component impairments that limit performance. Treatment techniques for the various impairments are provided. A chapter on the RIC community integration programme describes six skill areas and instructs how an O.T. can assist the head-injured patient to develop or improve in these areas. This section has an extensive chapter on evaluation, selection and application of technical aids. It includes an appendix on the use of computers and has numerous tables for comparison purposes and exhibits of equipment sources. The final part of this book has an informative chapter on the rationale and application of therapeutic groups. Another chapter appropriately discusses family education and discharge planning issues. There are several aspects of the book's uniform format that make it an appealing resource book. Subsections within the chapters are in bold print which makes for easy access. Similarily, important information is highlighted in point fashion. There are excellent labelled photo figures that enhance the text descriptions. Also there are numerous tables, exhibits, chapter referencing and a lengthy index. Students will find this book an excellent introductory text. Occupational therapists will find the book helpful for clinical problem solving, for evaluating their O.T. programme for head-injured patients and for further developing their programme's standards of care. Kim McElgunn Chambers B.Sc.O.T., OT(C)


Purpose: This study aims to determine the management implementation of the Storynomics concept of the Puputan Badung war in the city tours of Denpasar  and determine the management implementation model that can be used.
Research methods: The data collection methods used are interviews, participatory observations, documentation, and focus group discussions.
Findings: Storynomics tourism as one of the concepts echoed by the current government in its aim to promote historical and heritage stories in tourist destinations has been eyed to begin developing in each region in Indonesia. Denpasar City has started to adopt the concept of storytelling in packaging historical stories, but the synergy built between each stakeholder has not been optimal.
Implication: Good cooperation is needed between each related party in developing the concept of storynomics tourism in a sustainable manner in the future.


A procedure was substantiated for the assessment of land suitability for growing cereal crops. Soil and agroclimatic parameters were used as criteria. Their actual values were estimated with respect to winter wheat, winter rye, spring barley, and oats on synthetic maps in the form of a three-level scale (optimal, permissible, and not recommended growing conditions). More suitable patterns were proposed for growing cereal crops.


Recently, buttery-powered portable devices, which can use wireless LAN (WLAN), such as smart phones and tablet computers, are increasing. However, these devices consume more energy when using WLAN interfaces, and the battery lifetime is shorten. In order to reduce the power consumption of wireless stations, IEEE 802.11 specifies PSM (Power Saving Mode). However, PSM cannot save the energy optimally and it increases the transfer delay of packets severely. In this paper, to reduce the power consumption and suppress the transfer delay, we propose a power saving method using RTS/CTS handshake and burst transmission. Wireless stations save energy by sleeping for NAV (Network Allocation Vector) duration. In addition, we extend NAV duration with burst transmission. The number of packets transmitted per burst is decided so that the acceptable transfer delay of each packet is preserved. Finally, we show the effectiveness of the proposed method by computer simulation.


The invention relates to a preparation method of microcrystalline cellulose for being mixed with clavulanate potassium raw materials. Compared with a common microcrystalline cellulose preparation method, the preparation method comprises the following steps of: proportioning refined cotton with different polymerization degrees as raw materials, prolonging the hydrolysis reaction time, dewatering in a filter-pressing manner and obtaining the microcrystalline cellulose by adopting a secondary drying and dewatering method. The invention has the technical effects that in the microcrystalline cellulose obtained by the preparation method, the moisture is lower than 0.5 percent, the bulk density is 0.40-0.45 g/cm3, and the tap density is 0.55-0.60 g/cm3; and the microcrystalline cellulose is close to clavulanate potassium in bulk density and tap density to facilitate the uniform mixing of the microcrystalline cellulose and the clavulanate potassium.


It is natural to expect that the documents in a corpus will be correlated, and these correlations are reflected by not only the words but also the observed tags in each document. Most previous works model this type of corpus, which are called the semi-structured corpus, without considering the correlations among the tags. In this work, we develop a Correlated Tag Learning (CTL) model for semi-structured corpora based on the topic model to enable the construction of the correlation graph among tags via a logistic normal participation process. For the inference of the CTL model, we devise a variational inference algorithm to approximate the posterior. In experiments, we visualize the tag correlation graph generated by the CTL model on the DBLP corpus and for the tasks of document retrieval and classification, the correlation graph among tags is helpful to improve the generalization performance compared with the state-of-the-art baselines.


The study presents semi‐analytical solutions of two‐dimensional plane strain consolidation problem in unsaturated soils incorporating the lateral semipermeable drainage boundary by adopting Fourier sine series and Laplace transform. The two‐dimensional plane strain consolidation equations in the form of two‐order partial differential equations with three variables are firstly converted to two‐order partial differential equations with two variables, which are similar to those of one‐dimensional consolidation problem. The four‐order ordinary differential equations about excess pore‐air and excess pore‐water pressures are got by applying Laplace transform and the substitution method. Then, the solutions of excess pore pressures and settlement are achieved in the Laplace transform domain. Afterwards, on the basis of Crump's method, the inverse Laplace transform is conducted to obtain the analytical solutions in time domain. The comparison is conducted to verify the exactness of the obtained solutions, and the two‐dimensional plane strain consolidation property with the lateral semipermeable drainage boundary is illustrated and discussed. Parametric studies are demonstrated for the excess pore pressures and normalized settlement with the change of the boundary parameters, air‐water and lateral‐vertical permeability coefficients, and the distance and depth. It can be found that the lateral semipermeable drainage boundary impedes the consolidation rate obviously, and when different investigated parameters are adopted, the consolidation property is similar to each other under the later permeable and semipermeable drainage boundary conditions.


The biosynthesis and control of vitamin B6 in bacteria could be studied more easily if an organism which produced large amounts of this family of compounds could be found. Unfortunately, the measurements of bacterial vitamin B6 that have been reported have often failed to include the total extracellular vitamin B6, and thus they do not adequately reflect the total vitamin B6 in the whole culture. Consequently, the total vitamin B6 content of cultures of bacteria freshly grown in simple defined media has been measured to allow a comparison of their abilities to synthesize this vitamin. All identified bacteria were isolated before use from stocks obtained from either the American Type Culture Collection or the Department of Bacteriology, University of Florida. The measurement method for total vitamin B6 (pyridoxine) in bacterial cultures has been described (W. B Dempsey, J. Bacteriol. 90:431, 1965). Except for Thiobacillus thiooxidans, Streptomyces griseus, and Achromobacter xerosis, all data reported in Table 1 were obtained with samples withdrawn within one doubling time after the cultures reached stationary phase. The three exceptions had samples withdrawn within 24 hr after growth had stopped. T. thiooxidans cultures were filtered through coarse filter paper to remove sulfur particles before either optical density measurements or samples were taken. Dry weights were determined by drying to constant weight, at 110 C, duplicate, washed samples of bacteria containing a minimum of 15 mg each (dry weight). In addition to the identified organisms, 23 unidentified organisms from soils of widely scattered origin were tested after primary isolation on a glucose plus salts-agar seeded with Escherichia coli B-B6-53. This pyridoxineless mutant and the method of seeding it have been described (W. B. Dempsey and P. F. Pachler, J. Bacteriol. 91:642, 1966). The organisms used were those which retained the combined abilities to grow on a minimal medium and to cross-feed the seeded mutant after isolation in pure culture. When grown in medium A (Table 1), 19 of the organisms had vitamin B6 contents in the range 60 to 80 ng/mg. The remaining four organisms had higher amounts of vitamin B6, and these TABLE 1. Total vitamin B6 content in bacterial cultures


We present a case study on the use of mixed reality (MR) spatial computing in a fully remote classroom. We conducted a 10-week undergraduate class fully online, using a combination of traditional teleconferencing software and MR spatial computing (Magic Leap One headsets) using an avatar-mediated social interaction application (Spatial). The class culminated in a virtual poster session, using Spatial in MR to present project results, and we conducted a preliminary investigation of students experiences via interviews and questionnaires. Students reported that they had a good experience using MR for the poster session and that they thought it provided advantages over 2D video conferencing. Particular advantages cited were a stronger sense that they were in the presence of other students and instructors, an improved ability to tell where others were directing their attention, and a better ability to share 3D project content and collaborate.


A generalized FSK modulation employing FSK, PPM and APSK modulation alphabets is considered. The modulation combines a traditional APSK alphabet extended with a zero-symbol and the multiple-access. Analysis of the power spectral density (PSD) reveals that the bandwidth is significantly expanded whenever the transmission is periodically turned on and off. The overall probability of bit error and the overall data rate for multiple parallel generalized FSK transmissions are compared in single-user and multiuser scenarios. A rate-one repetition diversity scheme for real-valued transmitted signals is proposed to overcome the time and frequency correlations of communication channels between nodes. The overall energy consumption is shown to be reduced with the FSK modulation order, and by using multiple parallel FSK transmissions.


The Korteweg‐deVries equation describing nonlinear ion‐acoustic waves in a plasma with finite ion temperature is derived and the temperature dependences of soliton width and speed are obtained.


This paper describes the usage of IDDX monitors, which provide (periodic) data to be employed for predicting the remaining life-time of processor cores in homogeneous multi-processor SoCs during their lifetime. This forms the basis of self-repair with no down time for these SoCs and dramatically improving their dependability. This goal is accomplished by combining the optimally designed health monitors, such as delay and current monitors, to provide non-redundant data. Nowadays these can be implemented as embedded instruments which are IJATG compatible. Accelerated stress tests have been carried out using a set of processor cores in combination with a number of health monitors providing historic data. These results form the basis of a remaining lifetime model for delay (clock frequency), where the coefficients are determined by a genetic algorithm. After final test of a SoC these coefficients are periodically updated in an embedded processor during lifetime by the health monitors. In the case of seriously degrading cores, counteractions are automatically taken, like core isolation and (e.g. spare) replacement. Use is made of advanced run-time mapping software. The result is a zero mean down-time SoC with 40% reliability improvement in our 9 processor-core SoC.


Although recent technological advancements give rise to unprecedented amounts of biological data, our understanding of fundamental biological processes such as transcription regulation, cell differentiation or carcinogenesis did not keep pace with the growth of available data. In this thesis I present four computational studies which I conducted as a PhD student in the Computational Biology Group at the Department of Biosystems Science and Engineering at ETH Zürich. These studies focus on modeling epigenomic regulation of transcription and progression of cancer on inter and intra-tumor levels. We integrated epigenomic marker data – ChIP-chip (chromatin immunoprecipitation followed by microarray analysis) and ChIP-seq (chromatin immunoprecipitation followed by next generation sequencing) data with transcriptomics data – RNA sequencing and short RNA sequencing (Chapter 2), in order to assess how well binding of chromatin modifiers predicts transcriptional activity. The study was performed on Drosophila melanogaster S2 cells. We compared the predictive models for transcription as measured by RNA sequencing with the predictive models for stalling as measured by short RNA sequencing. This study reveals complex interactions of transcriptional regulators in the context of gene expression. Throughout my work on cancer development, I was particularly interested on modeling cancer progression. First, introduced a Bayesian version of Conjunctive Bayesian networks, a probabilistic model which identifies dependencies between mutations, together with an efficient algorithm for inference (Chapter 3). Therefore, we developed five MCMC structure move types which allow for significant speed-ups when sampling the structure of CBNs compared to state-ofthe-art Bayesian network MCMC sampling techniques. The method was applied to comparative genome hybridization (CGH) data from renal cell carcinoma and sequencing data glioblastoma. Furthermore, we established a method for discriminating dependent cancer events from independent cancer events (Chapter 4). This method is based on the observation that dependent events display a punctuated pattern of occurrence in time. We applied this method to copy number aberration (CNA) data from ovarian and breast cancer and single nucleotide variant (SNV) data from breast cancer. We found already known as well as novel driver candidates highly ranked in the list of predicted dependent events. Finally, we developed BitPhylogeny, a probabilistic framework for reconstructing intra-tumor phylogenies (Chapter 5). In contrast to competing methods which are based on SNV frequency or CNA data, we focused on CpG methylation data from bisulfite sequencing. Application of BitPhylogeny to 32 samples from four different colon cancers revealed the differentiation hierarchies present in these tumors.


1. American College of Cardiology Foundation/American Heart Association/American College of Physicians, Task Force on Clinical Competence. ACC/AHA/AAP recommendations for training in pediatric cardiology. Pediatrics. 2005;116:1574–1596 2. Brilli R, Spevetz A, Branson R, et al. Critical care delivery in the intensive care unit: defining clinical roles and the best practice model. Crit Care Med. 2001;29:2007–2019 3. Pollack MM, Cuerdon TT, Patel KM, Ruttimann UE, Getson PR, Levetown M. Impact of quality of care factors on pediatric intensive care unit mortality. JAMA. 1994;272:941–946 4. Pronovost PJ, Angus DC, Dorman T, Robinson KA, Dremsizov TT, Young TL. Physician staffing patterns and clinical outcomes in critically ill patients. JAMA. 2002;288:2151–2162 5. Dimick JB, Pronovost PJ, Heitmiller RF, Lipsett PA. Intensive care unit physician staffing is associated with decreased length of stay, hospital cost, and complications after esophageal resection. Crit Care Med. 2001;29:753–758 6. Rosenberg DI, Moss MM; American College of Critical Care Medicine of the Society of Critical Care Medicine. Guidelines and levels of care for pediatric intensive care units. Crit Care Med. 2004;32:2117–2127


Estimating the ideological positions of political actors is an important step toward answering a number of substantive questions in political science. Survey scales provide useful data for such estimation, but also present a challenge, as respondents tend to interpret the scales differently. The Aldrich–McKelvey model addresses this challenge, but the existing implementations of the model still have notable shortcomings. Focusing on the Bayesian version of the model (BAM), the analyses in this article demonstrate thatthe model is prone to overfitting and yields poor results for a considerable share of respondents. The article addresses these shortcomings by developing a hierarchical Bayesian version of the model (HBAM). The new version treats self-placements as data to be included in the likelihood function while also modifying the likelihood to allow for scale flipping. The resulting model outperforms the existing Bayesian version both on real data and in a Monte Carlo study. An R package implementing the models in Stan is provided to facilitate future use.


Numerous studies suggest that proinflammatory cytokines are involved in pathophysiology of depression and in the mechanism of action of antidepressant drugs. There are some clinical and experimental data indicating that antidepressants are able to reduce the levels of proinflammatory cytokines. Because the main source of cytokines in the brain are glial cells, the aim of our study was to investigate the influence of some antidepressants on tumor necrosis factor(TNF) release by lipopolysaccharide (LPS)-activated primary mixed rat glial cultures. Three antidepressants with different mechanism of action on monoaminergic systems: imipramine, moclobemide and fluoxetine were used. Mixed glial cultures were prepared from cerebral hemispheres of one day old newborn Wistar rats in Dulbecco's Modified Eagle's Medium supplemented with 10% heat-inactivated fetal bovine serum and 1% antibiotic solution. The cells were cultured for 12–14 days (37°C; 5% CO , 95% air, 80% humidity). Because the strongest stimulation of TNFrelease was observed when LPS was administrated at a concentration of 1 g/ml for 6 h, these parameters were applied in the experiments. Antidepressants were used at concentrations from 10 to 10 M/ml. Only fluoxetine was applied at concentrations up to 10 M because the higher concentration was cytotoxic as determined with the Trypan Blue exclusion method. Levels of TNFrelease were evaluated in culture medium with rat TNFELISA kits (R&D, USA). The intra-assay precision CV for TNFwas 7.4%. The cultures were stained with Ricinus communis agglutynin-1, lectin that binds to the surface glycoproteins on microglia (Vector, USA). The cells were examined using fluorescence microscope (TS-100/F, Nikon). The results of our study have shown that the studied antidepressants inhibit TNFsecretion by mixed glial cell cultures. Imipramine produced this effect at concentrations from 10 to 100 M, moclobemide from 10 to 10 M and fluoxetine – from 10 to 10 M. The obtained results support the previous observations that antidepressants are able to reduce the levels of proinflammatory cytokines and that TNFmay be involved in the central mechanism of action of imipramine, moclobemide and fluoxetine.


The productive relationship between translation and illustration exemplified in the eighteenth-century novel has, until recently, been almost completely ignored. A number of modern studies have identified the importance of illustration in the rise of the novel, considering the significance of its interaction with texts of the eighteenth century. However, there has been little evaluation of illustration in relation to the circulation of works from one country to another, or of the role it might play in the process of translation. Through several case studies and in particular Gravelot's plates for Tom Jones (1750) and La Nouvelle Héloïse (1761), this article explores the complex relationships between translating and illustrating literature in the Enlightenment, asking three questions: What does it mean to illustrate a translation? Can one translate an illustration? Is an illustrator himself a translator?


The aim of our paper is to analyse the treatment given by Zöe Akins (1886-1958), an American playwright from Humansville, Missouri, of the urban setting of New York in the second decade of the twentieth century in the play mentioned above. Akins, who follows a common pattern among successful American dramatists in her time, presents in Daddy's Gone A-Hunting (1923) a plot that is perfectly integrated in New York area. The Fields progression from a low middle class settlement in Harlem to other scenes of the city informs the development of family life towards désintégration. Akins, whose biography links her to New York as a successful distinction presents in Daddy's Gone A-Hunting (1923) a serious drama in which characters are very much influenced by New York's cosmopolitanism that turns out to be a divisive element within the play, as Julien Fields pursues at all costs an artistic career. In our presentation we will explore this linkage between characters and setting within the context of Zöe Akins' production and American Drama in the 1920's.


The knee joints of 12 patients with rheumatoid arthritis were biopsied to study the regenerated synovium 6 months to 6 years after synovectomy. Three of the 12 patients had clinical and microscopic evidence of the recurrence of rheumatoid inflammation. Biopsies in the remaining 9 patients all showed mild-to-moderate synovitis. In 4 of these 9 patients who were biopsied at intervals of 31/2 to 6 years after synovectomy, microscopic features of rheumatoid inflammation were quantitatively less severe than those observed in the initial specimens.


Trust is one of the important factors either fostering or damaging students' online teamwork learning experience. Building trust among team members has become a necessary step for a successful collaboration experience. The purpose of the article was to understand students' learning and teamwork experiences and further to investigate the relationships of learner-centered instructions, team trust, and social presence in an online learning community. Also, this article adds to the research on the role of social presence in promoting cognitive and affective trust. The results indicated there were positive correlations between learner-centered instructions and trust, between learner-centered instructions and social presence, and between trust and social presence. The study could provide suggestions for instructors teaching online courses for the implementation of learner-centered instructions and the importance of creating a social presence and building trust for students in a collaborative online learning environment.


In this issue of the journal Ding et al 1 discuss the strengths and weaknesses of the salaried employment option for GPs. Also in this issue David Jewell2 comments on the lack of partnership opportunities for newly qualified GPs. From Birmingham3 we hear of plans for franchised surgeries. The fear of the approach of 'Tesco Doc' grows. A few years ago it looked as if the sessional GPs might take over the world.4

'Where there is no vision the people perish' says the psalmist. Another translation has it 'where there is no vision the people run around aimlessly.' The map and territory of UK general practice is currently up for grabs (and the College's Road Map is an excellent attempt for the profession to grab this territory5). With the outlook for general practice so uncertain, the …


A method and an apparatus for trimming a reference cell of a semiconductor memory device are provided to improve accuracy of a reference cell trimming and to reduce a test time by using an internal bias current source. A semiconductor memory device(600) comprises a plurality of reference cells(210), an internal bias cell(610), and a trimming circuit(620). A reference cell current flows between a drain and a source of the respective reference cells based on a bias voltage for programming the reference cells. The internal bias cell generates an internal bias current capable of trimming. The trimming circuit trims at least one reference cell among the plural reference cells based on the internal bias current The trimming circuit includes a comparator(621), a bias voltage supplier(623), a reference current generator(625), and plural comparators(627-1,627-2). The comparator compares a reference cell current flowing on one reference cell among the reference cells with the internal bias current, thereby outputting a comparison signal. The bias voltage supplier a bias voltage for programming the one reference cell based on the comparison signal. The reference current generator generates plural reference currents based on the internal bias current. The plural comparators compare the plural reference currents with the reference cell current. The bias voltage supplier supplies a bias current for erasing the one reference cell based on the outputs from the plural comparators.


398 Background: Adjuvant radiation therapy (RT) for resectable pancreatic cancer remains controversial. We evaluated whether a previously validated molecular signature of tumor radiosensitivity (RSI) is prognostic for survival in pancreatic cancer. Methods: We identified patients treated with upfront surgery between 2006 and 2012. Briefly, RSI score is derived from the expression of 10 specific genes and a linear regression algorithm modeled on SF2 of 48 cancer cells (RSI, high index = radioresistant). We assessed the relative radiosensitivity of pancreatic cancers compared with other common cancers and then tested the association of RSI with overall survival (OS). Results: Compared with other common cancers such as lung, breast, and prostate, pancreatic cancers were more radioresistant as a group (p<0.0001). We identified 80 patients who underwent upfront surgery with both RSI and clinical outcome available (49 RT, 31 no RT). Median follow-up among surviving patients was 4.1 years. Median OS for radiosen...


Pistachio Bushy Top Syndrome (PBTS) is a serious problem for pistachio growers in the western U.S. but the cause of this disorder remains controversial. Recently, it was proposed that the Rhodococcus species, R. fascians and R. corynebacterioides caused PBTS outbreaks in 2011 and 2015. To investigate the association of Rhodococcus spp with PBTS in California's pistachio growing region, Rhodococcus-like isolates were collected from diverse hosts and environments, including pistachio nurseries and orchards. Whole genome sequence analysis of 231 isolates revealed their evolutionary relationships and identified six Rhodococcus species. Combined with data on geography and host of origin, the data reveal that Rhodococcus generally, and R. fascians specifically, is ubiquitous in nature, frequently occurring in both symptomatic and asymptomatic pistachio trees and on other woody and native species. Core gene and SNP-based phylogenies, and pan-genome analyses differentiate R. fascians into distinct genotypes. Although we found examples of common genotypes shared between nurseries and orchards, the observed patterns are most consistent with an environmental source of strains and do not support a scenario where individual nurseries are point sources of Rhodococcus. Moreover, none of the collected strains harbored known virulence genes, calling into question the role of these common, environmental bacteria in causing PBTS.


One hundred years after the creation of the figure of the pedagogical manager, the "remote ancestor" of the class tutor (Engracia Castro, 1994; Joao Barroso, 1993; Virginio Sa, 1995), it seems appropriate to reflect upon the role of this school agent, to whom a great organizational relevance is frequently assigned within the school of masses. This pedagogical manager is usually associated with three functions: relating with the students in the class; relating with parents; relating with other teachers of the same class. We will focus particularly on his/her capacity to intervene near other teachers of the class, especially by questioning the degree of agreement between functional demands and the powers which can be called upon to legitimate such intervention. 161 O director de turma na escola Portuguesa


The opening of cyclopropanes, bearing a carboxyl group, in formic acid leads to complex mixtures containing less than 30% lactones formed by an intramolecular nucleophilic process during the reaction. We show that the relative stereochemistry of the carboxyl group and the cyclopropyl group does not determine the proportion of lactone formed. On the other hand, when the opening is performed by a Lewis acid (BF3−etherate), lactonisation is the major route (84%) and although the mechanism of intramolecular cyclisation is not yet clear, this reaction provides a good route to lactones. [Journal translation]


Abstract Polymers can be tailored to provide different benefits in Fabric & Home Care formulations depending on the monomers and modifications used, such as avoiding dye transfer inhibition in the wash, modifying the surface of tiles or increasing the viscosity and providing suspension properties to consumer products. Specifically, the rheology modification properties of synthetic and natural polymers are discussed in this chapter. The choice of a polymeric rheology modifier will depend on the formulation ingredients (charges, functional groups), the type and the amount of surfactants, the pH and the desired rheology modification. Natural polymeric rheology modifiers have been traditionally used in the food industry, being xanthan gum one of the most well-known ones. On the contrary, synthetic rheology modifiers are preferably used in paints & coats, textile printing and cleaning products.


The paper discussed the design and implementation of network monitoring and control system for sluice gate station. On the basis of original analogue system, it used embedded video server AXIS2400 to form remote network monitoring and control system by network interconnection, which realized remote monitoring and control for sluice gate station.


To determine the accuracy of ultrasmall superparamagnetic iron oxide (USPIO)‐enhanced magnetic resonance imaging (MRI) for nodal staging in patients with head and neck cancer.


This research was intended to know a relationship between (1) Knowledge of learning achievement evaluation with effective teaching of teachers, (2) Instructional analysis capability with effective teaching of teachers, (3) both Knowledge of learning achievement evaluation and Instructional analysis capability With Effective caching of teachers.
This research was performed in Instructional and Educational Department with purpose to understand the correlation of Knowledge of learning achievement evaluation and Instructional analysis capability for effective teaching of teachers, either individually as well as colletively.
The research population was the entire Teachers of Social Primary School in Instructional and Educational Department of Binjai that amounts to 152. The research data was obtained by objective tests that its had been respondent by 38 respondents.
The data analysis was performed quantitatively with the use of descriptive statistics and analysis on product moment correlation, and multiple regression analysis. The interpretation of the results of data analysis was taken on 0, 05 signification.
The hypothesis of this research are: First, there is a positive correlation between knowledge of learning achievement evaluation with effective teaching of teachers. Second, there is a positive correlation between instructional analysis capability for effective teaching of teachers. Third, there is a positive correlation between knowledge of learning achievement evaluation and instructional analysis capability for effective teaching of teachers.
The results of data analysis pointed out that the correlation between the variable of knowledge of learning achievement evaluation and instructional analysis capability for effective teaching of teachers was Ry12 = 0, 74, with regression line
equation was; Y = 0,14 + 0,57 X1 + 0,23 X2, where as the contribution of this variable for effective teaching of teachers was 54, 69 %. Partially, (1) there is a positive correlation between knowledge of learning achievement evaluation with effective teaching of teachers was ry12 = 0, 549, where as the contribution of this variable for effective teaching of teachers was 30, 15 %; (2) there is a positive correlation between instructional analysis capability for effective teaching of
teachers was ry12 = 0, 740, where as the contribution of this variable for
effective teaching of teachers was 54, 82 %.


THIS paper is compiled from notes made on patients suffering from Blast Injuries "of the Ear, examined in various parts of the world from 1939 until the present day. The mode of production of the blast varied under different conditions of warfare, but no relationship could be traced between the causal weapon and the injury sustained. The fifty-six cases analysed were seen recently : they were nearly all battle casualties and included not only British troops, but also Indian, Greek, Polish, Yugo-Slav personnel, and German prisoners of war. Though few in number, they illustrate the effects of blast on the human ear which the Army Otologist is called on to treat. Of these cases, twenty-five were middle-ear injuries, twenty-three inner ear injuries, and eight were hysterical. Of the middle-ear injuries, nineteen patients had one ear only injured, and six had both. Fourteen were infected when first seen ; they had been injured at periods varying from seventeen days to four years previously ; one, injured six weeks before examination, had a mastoid infection which required operation. Otorrhcea was the commonest symptom, only nine complained much of deafness, and of these, three had a fairly severe hearing loss, and were probably cases of associated injury to the inner ear. Of the inner ear injuries, five patients were severely deafened, and these were distinguished from eight cases suffering from hysterical deafness by means of the cold caloric test. Of the remaining eighteen inner ear injuries, seven were slight in degree whose main complaint was tinnitus, and eleven had moderate degrees of inner ear deafness, who complained of varying degrees of deafness.


he literature on constitutional design focuses on the incentives that shape the behavior of government officials and other constitutional actors. Incentive-based accounts justify elections as a means of constraining officials to promote the public welfare, or at least the welfare of the median voter, justify the separation of powers as a means of making "ambition . . . counteract ambition," justify negative liberties, such as free speech and free association, as necessary correctives to the incentives of incumbent officials to suppress political opposition, and so forth. T


The authors present a typology of the interdisciplinary representations and practices of primary teachers in Quebec based on the results of research carried out over the last ten years. The poles of two crossed continua illustrate four principal tendencies. These tendencies show representations and practices that are far from the idealized conception of reciprocity among scholarly disciplines promoting the establishment of effective complementary methods and con- structive linkages.


The application of Artificial Intelligent approaches was introduced recently in protection of distribution networks. These approaches started with introducing Fuzzy Inference System (FIS), then using Artificial Neural Network (ANN).In this research, the application of Adaptive Neuro Fuzzy Inference System (ANFIS) for protection of bus bars will be illustrated. The ANFIS can be viewed as a fuzzy system, a neural network or fuzzy neural network. The objective of this research is firstly to detect the fault occurrence on bus bar, secondly locating the fault. The fault detectors and locator are firstly trained using ANFIS technique and then they are tested in diversity of system conditions with respect to the fault types, inception instant, resistance and pre-fault conditions.


Digital Mock-Up (DMU) is a digital, centralized and structured representation of all productions from project actors. Concerning AEC sector Digital Mock-Up for Construction (DMUC) refers to the adaptation of previous technology to this industrial field. Civil design seems however different from design of manufactured products, because of : multiplicity and heterogeneity of actors, creation of a unique product. Therefore involved processes need to be specifically analysed. This work aims to propose mechanisms to aid DMUC synchronization. Before that, we show that existing tools cannot be directly adapted to AEC sector. To do so, this thesis focuses on tracking changes within a DMUC during design process, thanks to comparison of structured information (structural information). We consider also the meaning of used concepts (semantic comparison). This analysis is done at the meta-model level (EXPRESS language) instead of a specific data model (IFC, IFC-BRIDGE). This generic approach guarantees some robustness for future evolutions of DMUC. From a configuration based on a structural helper (only a few lines of XML code), the software engineer automatically generates a library of structural comparison, adapted to the application data model. Semantic analysis makes the system very flexible : partial extract of information, definition of semantic equivalences and tolerance on numerical values. Designed system does not depend on any data persistence tool. Besides, extraction of information is carried out without any model mapping. C++ implementation of structural and semantic comparison uses tools of automatic generation of source code. Last this work provides several perspectives when they are associated to predictive and reactive design activities.


The relations about macroeconomic policies and inflation are the main issue of the theorists of the world.Through the test including five variances,we conclude the relations about the expenditure,money supply and inflation levels.The result is that,China's inflation is not only the "Money affection"but also the"Finance affection".The meaning is that it's supply the reference for China to take the suitable policies to stabilize its inflation level.


Purpose

The purpose of this paper is to investigate how managers perceive risks associated with sharing information with trading partners, and how they attempt to mitigate them.

Design/methodology/approach

In this exploratory New Zealand study, qualitative research was conducted involving semi-structured interviews with boundary spanning managers who are responsible for inter-organizational interfaces. Multiple case studies in different industries are used to highlight managers' perceptions of risks in data exchange process throughout the supply network, and their underlying reasoning.

Findings

Managers perceive several types of risks when exchanging information across external supply chain interfaces, and adopt different approaches to handling them. The research also reinforces the vital role played by interpersonal relationships and trust as key enablers of inter-organizational cooperation.

Research limitations/implications

The findings are based on a small sample of 11 case companies based in a single New Zealand province, thereby potentially restricting generalizability. Future work could usefully extend the sample size in order to investigate the correlations between firm sizes, levels of trust, and degrees of data integration within particular industry sectors.

Practical implications

The findings will help managers understand and evaluate different types of risks in the data exchange process, and enable them to make better decisions that enhance information sharing and supply chain performance.

Originality/value

Perceived information sharing risks are peculiar to the individual actors, and as such need to be mitigated through changes to their socially constructed perceptions. This work extends the literature on understanding the various dimensions of inter-organizational information sharing.


A series of 25 cases with clinical signs indicative of oral lichen planus was examined. Samples stained with haematoxylin-eosin as for traditional histology and others for DIF were taken in each case. The results obtained by both techniques were then compared with the clinical picture. It is concluded that DIF is a valuable diagnostic aid in doubtful cases.


A new formulation of Boussinesq-type equations for wave-current interaction is presented with focus on the inclusion of the mean depth change due to the presence of currents.A computational velocity is introduced to make the water depth in the dispersion relation the mean water depth including the effect of mean current and of Pade[4,4]accuracy.The model is applied to simulate the wave field affected by two mean current systems,strong current on an offshore bar and rip-current on sloping beach,and it is found that the present model is capable of giving reasonable numerical results of wave-current interaction.


How would inner-city residents respond to the incorporation of trees and grass in their neighborhoods? Law enforcement officials have argued that, in these settings, trees and other forms of vegetation increase fear. Tree density, tree placement, and levels of grass maintenance were manipulated in photo simulations of neighborhood outdoor space. One hundred residents of Chicago's Robert Taylor Homes living adjacent to the space rated the images with respect to preference and sense of safety. Although tree placement (subspaces created by trees, formality of arrangement) had little effect on sense of safety and no effect on preference, both tree density and grass maintenance had strong effects on preference and sense of safety (η2s from .49 to .89). Surprisingly, tree density and grass maintenance increased both preference and sense of safety. Results suggest that-contrary to some views-trees and grass maintenance can increase sense of safety in inner-city neighborhoods.


Objective To understand the cognition on depression of nurses in department of internal medicine of general hospital.Methods The data were collected by handing out questionnaires.(Results Among) the participants,24.7%(19 nurses) of them had never studied the knowledge on psychosis;35.1%(27 nurses) did not know the symptoms of depression;28.6%(22 nurses) had never tended the patients with psychosis;23.4%(18 nurses) did not know that the suicide rate of depression was highest;44.2%(34 nurses) obtained the knowledge via school education;100% of them believed it necessary to study the knowledge on depression;most nurses in incretion department understood depression,however,few nurses in digestion department understood depression,and the difference was significant(P0.05).Conclusions Depression of inpatients in department of internal medicine should be attached importance to and nurses' knowledge should be promoted.


Intramolecular 1,3-dipolar cycloaddition reactions of chiral azomethine ylides obtained by thermal ring opening of chiral aziridines 7a, b and 8a, b are investigated. Synthesis of these aziridines 7a, b and 8a, b is described.


A variety of di- and triarylphosphines is successfully synthesized by CsF-catalyzed coupling of the corresponding trimethylsilylphosphines with aryl fluorides under mild conditions.


Communitarianism in Corporate Law: Foundations and Law Reform Strategies (David Millon.) Working Toward a New Paradigm (Lynne L. Dallas.) Some Observations on Writing the Legal History of the Corporation in the Age of Theory (Gregory A. Mark.) The Death of Contractarianism and the Vindication of Structure and Authority in Corporate Governance and Corporate Law (Douglas M. Branson.) Experiencing Limited Liability: On Insularity and Inbreeding in Corporate Law (Theresa Gabaldon.) Game Theory and the Restoration of Honor to Corporate Laws Duty of Loyalty (William W. Bratton.) Trust Contract Process (Lawrence E. Mitchell.) Promoting Economic Justice in Plant Closings: Exploring the Fiduciary/Contract Law Distinction to Enforce Implicit Employment Agreements (Marleen A. OConnor.) The Legitimacy of Multinational Corporations (Eric W. Orts.) On the Frontier of Capitalism: Implementation of Humanomics by Modern Publicly Held CorporationsA Critical Assessment (Lewis D. Solomon.).


Computer aided intelligent safety measures for the building construction based on the Internet information system is studied in this paper. The architecture of an information system does not refer to a specific information system, but a summary of the common characteristics of all information systems. With this basic feature, this paper adopts the Internet info-system as the basis for the model design. In the sensor network topology, the most used are star type, mesh type, and star-network hybrid type. Each topology has its own advantages and disadvantages, and the advantages of different models are selected to construct the efficient model. The combincation with the contruction engineering is studied and simulated. The designed system can help the process intelligent and smart.


The author shows that, if the number of the states of the reduced flow table of an iterative logic array (ILA) is not a power of 2, then, the truth table verification of the ILA requires to test it exhaustively. Thus, in this case the theory presented by F.J.O. Dias (1976) and allowing the truth table verification of ILAs by means of C-tests, is not valid. Then the author extends this theory to the case where the ILA cells have some inputs in common (such ILAs are for instance ALUs, and the rows of multiply and divide arrays).<<ETX>>


entrepreneurship engineering and Science of Abstract As a highly multidisciplinary field, Biomedical Engineering (BME) has a complex and ever-evolving identity. Little is known about how individuals in BME, especially students, perceive how BME intersects with and incorporates other science and engineering disciplines. Additionally, individual identity is recognized as a crucial factor in choosing and persisting in an academic discipline, yet there are few studies examining how individuals in BME professionally identify. Understanding such identities and how they are formed may be valuable in innovating BME instruction to properly meet students' academic and professional needs. This work explores how BME students and professionals view themselves and the field of BME as related to traditional science and engineering influence. This paper presents quantitative analysis of Likert-scale survey data collected from an annual professional meeting held in 2018. A total of 150 survey responses were analyzed, including 63 undergraduate students, 53 graduate students, and 27 professionals. Descriptive statistical analysis reveals that on average, survey participants view BME as both science and engineering to an equal degree and identify strongly as both engineers and scientists. A multi-step regression was constructed to analyze what predictor constructs contribute to a stronger identity for either engineering or science and how these identities influence career path goals and choices. This study shows that recognition from others is a significant predictor of individual identity and that personal interest is a significant predictor of how an individual views BME. Gender was not found to influence professional identity or perception of BME in this study.


ASSESSING CREATIVITY IN SHARK TANK ENTREPRENEURIAL PITCH MEETINGS This study tested the dual-process theory of creativity judgments in Shark Tank TV entrepreneurial pitch meetings. It extends the work of Elsbach and Kramer (2003) assessing creativity in Hollywood film pitch meetings to entrepreneurial pitch meetings. Entrepreneurs are identified by Elsbach and Kramer (2003) as a group where similar sociological and psychological creativity assessment processes may exist. How creativity impacts effective decision making and group performance is the subject of much sociological and psychological research (Kelley, 2001). Elsbach and Kramer (2003) posited that one way to increase productivity and creativity is to find ways to identify people with creative potential. Kelley (2001) stated employee track records are one source of picking creative people. Personality tests are also another readily available measuring stick to identify persons with potential creativity (Kelley, 2001). But these measuring sticks are not usually available in creativity assessment meetings like the Hollywood pitch or the entrepreneurial pitch meetings (Elsbach, & Kramer, 2003). In creating a systems view of creativity Csikszentmihalyi (1999) posited that the creative environment has a cultural aspect called the domain; and a social aspect called the field."Creativity is a process that can be observed only at the intersection where individuals, domains, and fields interact, to occur, a set of rules and practices must be transmitted from the domain to the individual. The individual must then produce a novel variation in the content of the domain. The variation created by the individual, then must be selected by the field for inclusion in the domain" (Csikszentmihalyi, 1999, p.315).Creativity is likely perceived in Hollywood pitches when a person makes a change to the knowledge domain. Certain pitchers have personal qualities or the good fortune to be well positioned with respect to the domain to impact creativity assessments (Csikszentmihalyi, 1999).Industry decision makers and experts have long sought the touchstone schema of identifying and promoting creative persons to lead roles (Carland, Hoy, Boulton and Carland, 1984). They suggest an intuitive cognitive process is used and known by industry insiders as 'you will know them when you see them' but this has not been quantified (Carland, Hoy, Boulton, & Carland. 1984). With a great deal of money involved in Hollywood deals and entrepreneurial pitches a logical decision methodology would provide experts a framework for more efficient decisions (Elsbach, & Kramer, 2003). Elsbach and Kramer (2003) posit industry executives decision making processes in the film industry and entrepreneurial creative pitches would be enhanced by the development of logical decision criteria matrices. Pitchers are often judged in a process that is unspecified in literature based on personality and perceived economic potential in the pitch meeting (Elsbach, & Kramer, 2003). Elsbach and Kramer (2003) conclude that there are many commercial applications for a decision making matrix for determining creativity in 'pitch meetings'; but none is readily available. There is little agreement among experts on a framework for a decision-making model to identify creative entrepreneurial potential (Ensley, Carland, and Carland, 2000). EXISTING THEORY AND RESEARCH ON PITCH ASSESSMENT The research on pitch creativity assessment focused on personality traits and the use of social judgment theory until the development of the dual-process theory of creativity judgment (Elsbach, & Kramer, 2003; Ensley, Carland, & Carland, 2000). The dual-process theory is based on two social and cognitive processes whereby experts make decision on pitchers creativity. In the first process catchers determine pitchers creativity based on personal categorization and prototype matching to one of several perceived creative prototypes (Elsbach, & Kramer, 2003). …


Four not-for-profit systems are banding together in an arrangement that falls short of a merger but aims to increase the partners' buying power. "We favor the idea of local control and local governance. It's not financial because we've had as good a financial year as we've had in a decade," says Steven Edwards, president and CEO of CoxHealth.


SPILLWAY, GREENUP LOCKS AND DAM
OHIO RIVER, KENTUCKY AND INDIANA
Hydraulic Model Investigation
TECHNICAL REPORT NO. 2-572
July 1961
U. S. Army Engineer Waterways Experiment Station
CORPS OF ENGINEERS
Vicksburg, Mississippi
ARMY-MRC VICKSBURG, MISS.
PREFACE
The model investigations reported herein were authorized by the Division
Engineer, U. S. Army Engineer Division, Ohio River, by letters to the
U. S. Army Engineer Waterways Experiment Station dated 18 March 1957 and
5 December 1957, at the request of the U. S. Army Engineer Districts,
Huntington and Louisville. The studies were accomplished in the Hydraulics
Division of the Waterways Experiment Station during the period April 1957
to January 1958 by Messrs. E. S. Melsheimer, R. S. Cummins, and N. V. Cowan,
under the general supervision of Messrs. F. R. Brown and T. E. Murphy.
This report was prepared by Messrs. Melsheimer and Murphy.
Col. A. P. Rollins, Jr., CE, and Col. Edmund H. Lang, CE, were Directors
of the W


The aim of this paper is to present the concept of making a simulation model of the multimodal cargo lines group including water transport and the principles of its formation in the form of interconnected similar modules. The paper presents a generalized algorithm for choosing the optimum multimodal transportation vari- ant on the basis of simulation modeling. The matter of the paper is given on the example of the organization of export and import cargoes multimodal transportation by Belarus in southern direction.


Objective MyD88(myeloid differentiation factor 88) is the central adapter protein for signal transduction of TLRs(Toll-like receptor) and the interleukin (IL)-1 receptor family that is critical for an effective immune response against a wide range of microbial pathogens and plays a central role in sepsis.In the present study,we investigated whether the polymorphisms of MyD88 gene are associated with the susceptibility to and disease severity of sepsis.Methods We used a case-control genetic association study design to determine if common genetic variation in MyD88 was associated with sepsis risk in a Han Chinese population.Haplotype tagging single nucleotide polymorphisms (htSNPs) were selected from the HapMap database.The htSNPs were genotyped in 255 patients with sepsis and 260 control subjects by the Beckman SNPstream genotyping platform.The associations with the susceptibility to and disease severity of sepsis were estimated by logistic regression,while controlling for confounding factors,including age,sex,smoking status,drinking status,chronic diseases status,APACHE Ⅱ and critical illness status.Results Five MyD88 SNPs were tagged by 3 htSNPs and only rs7744 is fit for genotyping analysis.Genotype frequencies of rs7744 are conformed to the Hardy-Weinberg equilibrium in both patients and controls.On the basis of logistic regression analysis with adjustment for confounding factors,no significant association was found between the polymorphisms and susceptibility to sepsis.Also no significant association with the septic shock,death due to sepsis and the number of organ dysfunction was found with the MyD88 polymorphisms.In smoking subgroup the OR for G/A genotype developing sepsis was 2.19(95% CI 1.13 ~ 4.25,P=0.034) compared with A/A genotype.Conclusions Our findings suggest that the MyD88 gene polymorphisms might not play a major role in mediating susceptibility and disease severity to sepsis,smoking was a independent risk for developing sepsis.


This article interprets the temporalization of time in Freudian psychoanalysis, particularly on the analysis of the first trauma theory. Sexuality is shown to have a temporalizing function determined by its separating character and expressed in the term deferred-action,both in the progressive and regressive sense used by Freud. The symbolization implicated in the trauma theory and the repression are discriminated in their relations to temporality. The basis of Freudian thinking between genesis and structure is discussed, concluding with an evaluation of the deconstruction of Freud's scientific heritage in psychoanalysis as founded by him.


Acidianus brierleyi was demonstrated to remove pyritic sulphur from coal. A. brierleyi was also found capable of catalyzing the removal of what is normally reported as organic sulphur from coal 171US34. A kinetic analysis was performed by assuming a first order reaction. The first order kinetics allowed a comparison with literature data for Thiobacillus ferrooxidans. Also, formation of jarosite was taken into account in the analysis. The simple first order kinetics was observed to fit the data on removal of sulphur satisfactorily.


The aim of the present study was designed to develop model controlled release matrix tablet formulations for aceclofenac. Aceclofenac tablets at different drug to polymer ratios were prepared by the direct compression method using Carbopol 934P. The influence of the proportion of the polymer and several co-excipients like lactose, microcrystalline cellulose, and dibasic calcium phosphate on the release rate of the drug from the tablets was studied. In vitro drug release studies carried out in 0.1 N Hcl was found to occur both by diffusion and swelling-controlled mechanisms exhibiting non- Fickian transport. The drug release was found to follow zero order kinetics. The two co-excipients, lactose and microcrystalline cellulose enhanced the release rate of aceclofenac, while dibasic calcium phosphate exhibited a much slower release of drug from the prepared matrices. Pharmaceutical Sciences


If I and J are ideals in a Noetherian ring R, then I and J are projectively equivalent in case (Ii)a = (Jj)a for some positive integers i, j (where Ka denotes the integral closure in R of the ideal K) and the form ring F(R, I) of R with respect to I is the graded ring R/I ⊕ I/I2 ⊕ I2/I3 ⊕ …. These two concepts have played an important role in many research problems in commutative algebra, so they have been deeply studied and many of their properties have been discovered. In a recent paper [13] they were combined to show that a semi-local ring R is unmixed if and only if for every ideal J in R there exists a projectively equivalent ideal J in R such that every prime divisor of zero in F(R, J) has the same depth. It seems to us that results similar to this are interesting and potentially quite useful, so in this paper we prove several additional such theorems. Namely, it is shown that all ideals in all local rings have a projectively equivalent ideal whose form ring is fairly nice. Also, a characterization similar to the just mentioned result in [13] is given for the class of local rings whose completions have no embedded prime divisors of zero, and several analogous new characterizations are given for locally unmixed Noetherian rings. In particular, it is shown that if I is an ideal in an unmixed local ring R such that height(I) = l(I) (where l(I) denotes the analytic spread of I), then there exists a projectively equivalent ideal J in R such that Ass (F(R, J)) has exactly m elements, all minimal, where m is the number of minimal prime divisors of I (so if I is open, then F(R, J) has exactly one prime divisor of zero and is a locally unmixed Noetherian ring).


Metal-Ligand Interaction. Reactions of Coordinated Carbonyl Compounds with Nucleophiles. Other Reactions of Coordinated Ligands with Nucleophiles. Stabilisation of Anions and Reactions of Coordinated Ligands with Electrophiles. Cyclic Ligands and the Template Effect. Encapsulating Ligands and Supramolecular Chemistry. Aromatic and Heterocyclic Ligands. Oxidation and Reduction of Coordinated Ligands.


We consider a singular integro-differential operator Λ on the real line which includes as a particular case the Dunkl operator associated with the reflection group Z2 on R. We build intertwining operators of Λ and its dual Λ into the first derivative operator d/dx. Using these intertwining operators, we firstly establish a PaleyWiener theorem for the Fourier transform associated to Λ, and secondly introduce a generalized convolution on R tied to Λ.


Because of its stratigraphic peculiaritics and palcontological richness, the Santana Formation is distinct among the scdimentary units that make up the Mesozoic sequence of northeastem Brazil. To the already important amount of data on this formation, the author adds here the results of this Doctoral Thesis research. This paper comprises the first of four parts of this work. Presented in a concise way, are some geological considerations about the studied area and the systematic descriptions of thirty genera and fifty-eight species of spores of the Subturma Azonotriletes, of which one species is new.


Essential cryofibrinogenaemia is a rare disorder characterized by cryofibrinogens without cryoglobulins. Connective tissue disorders and thrombophilia are known to increase risk of pre-eclampsia, but pre-eclampsia has not previously been reported in association with cryofibrinogenaemia. We report the case of a 32-year-old woman with recurrent severe pre-eclampsia diagnosed with essential cryofibrinogenaemia.


The direct and indirect (i.e. autoionising) contributions to the collisional ionisation cross section of N2+ have been calculated in the Coulomb-Born and distorted-wave approximations for incident electrons with up to twice the outer-shell ionisation energy. The results of these two methods differ by less than 10%. Autoionisation is found to exceed the direct contribution by about a factor of two in agreement with the approach suggested by Burgess et al. (1977). The present results are compared with those of other theoretical calculations and with experimental data.


Cancer and accidents now comprise the two leadingcausesof deathinchildren beyond the age of two years. This increase is a relative one due to the success of pub lic health prophylactic measures and the effectiveness of antibiotics in the preven tion and treatment of infections. Sarcomas far outnumber carcinomas in pediatric cases. Tumors seen in the first five years are usually of congenital origin. Whiletheyexist beforebirth, theyarenot recognized until later, when a clinical diag nosis becomes possible. Benign tumors are actually more frequent in early life. Many are hamartomas which are tumor-like con genital malformations resulting from over development of one or more tissue ele ments present at the site of the tumor, such as hemangiomas. In the proper management of the can cers of infants and children, cooperation among pathologist, radiologist, surgeon and pediatrician is necessary. The chief means of treatment are surgery, chemo therapy and irradiation. While standard textbooks frequently give dire prognosis insome of thesetumors,actually many of them offer a much more hopeful out look than they did before the advent of newer methods of treatment. The etiology of thesetumorsisstill elusive. However,a number of interest ing factors are known; for instance, tera toid tumors are found more frequently where there is a history of twinning. An other interesting observation is that ma lignant melanoma can be diagnosed histo logically in children, whereas clinically it does not become malignant until after childhoodhas passed.Fiftypercentof all tumors in childhood occur in the first five years. After this, there occurs a drop in incidence, with a new rise after ten years of age. Infection may play a part in the etiology since in some cases the onset of a lymphoma appears to have


This study was conducted to gather the basic data on making good use of a kind of groundsel (Ligularia fischeri). We have made methanol extracts from Ligularia fischeri and have also determined the effects of extracting temperature and time on the physiological activities of methanol extracts from Ligularia fischeri. Total phenolic compound and flavonoid contents in the methanol extracts from Ligularia fischeri at the extracting concentration of 1,000㎎ㆍL?¹ were 75.8-297.7㎎ㆍL?¹ and 45.6-173.6㎎ㆍL?¹. Total phenolic compound and flavonoid contents, and DPPH radical scavenging activities were most increased when Ligularia fischeri was extracted with methanol at 95℃ for 6 hours, however, nitrite radical scavenging activities were extremely increased at 75℃ for 12 hours by 97.4%. At 200㎎ㆍL?¹ and 400㎎ㆍL?¹ methanol extracting concentration, the hyperplasia of lung cancer cells (Calu-6) and stomach cancer cells (SNU-601) were effectively inhibited over 90%. Consequently, it was assumed that Ligularia fischeri was a functional vegetable with a higher physiological activities. Making the processed foods, it had better make the extracts from Ligularia fischeri with methanol at 95℃ for 6 hours.


This study aimed to estimate the trunk twist angle from the shoulder and hip rotation angles in short-distance crawl swimming and to elucidate the twist motion of the relationship between the trunk and the rotation angular velocity in response to changes in swimming speed. Swimming speed during the experimental trials was computed from the subject's best times in the 50 and 100m crawl swims. Wireless self-luminous LED markers were attached to seven locations on the body. The actual coordinate values of the LED markers were obtained using 18 cameras for underwater movements and 4 on the water for above-water movements. A comparison of the rate of change between trials revealed a high correlation (r = 0.722, p < 0.01) between the twist angle and shoulder rotation angular velocity in the push phase. In the same phase, a high correlation (r =0.748, p < 0.01) was also found between the twist angle and the angular velocity of hip rotation. These results suggest that swimmers increase the twist angle of their trunks to obtain a higher swimming speed. Moreover, the trunk muscle group increases its activity before starting the main motion of the twist back motion, and stretch-shortening cycle (SSC) motion may be performed in the trunk.


Online learning activity should not become an excuse for educators not to implement learning models in their teaching activities. Learning models are implemented to empower students' thinking skills, including critical thinking skills and metacognitive skills. Students should be equipped with the 21st century skills. This research aimed at investigating wheteher or not there was a correlation between critical thinking skills and metacognitive skills towards the learning results of Biology education students. This correlational research involved 64 second semester students. The research data were collected using the critical thinking skill rubric and metacognitive skill rubric. The collected data were analyzed using SPSS 23 application software. The results of the data analysis showed that there was a positive correlation between critical thinking skills and metacognitive skills towards learning results with a significance value of 0.001. The relative contribution of critical thinking skills and metacognitive skills towards learning results was as much as 21.5%. The effective contributions of critical thinking skills and metacognitive skills towards learning results were 3.5 % and 18 % respectively. Based on this results, it is recommended that the educators, especially lecturers, implement RWRS learning model in their teaching activities to improve students' critical thinking skills, metacognitive skills, and learning results.


for maternity cases and for diseases of women. Tlie soutli front faces Gloucester Street, and the north front adjoins the towing path of the canal. The chief elevation, including the circular dormitory, faces due south, and will obtain the greatest possible amount of sunshine, while the oblong dormitories have their ends facing south, and the sides of the wards will get both morning and afternoon


Title: The assessment of developmental status using the Ages and Stages questionnaire-3 in nutritional research in North Indian young children.


This paper is based on China Statistical Yearbook and the sample survey data,carried out by the National Bureau in Henan and other 17 provinces for many years,which contains the resident poultry meat and egg consumption in recent years. Using quantitative analysis method combining qualitative analysis,in-depth analysis was conducted on developments and changes in the production of poultry products,production and consumption,consumption of poultry products and residents income, and main existing problems in the future,12th five-year plan pridictions were made for the period poultry products consumption trends of scientific prediction,designed to provide reference. for interested parties on the scientific development of livestock production to ensure the effective supply of livestock markets,and further increase the income of the farmers to develop macro decision-making.


In this work, thermal properties especially phase change heat transfer properties of one new type of nanostructured heat transfer fluid: Water/Polyalphaolefin (PAO) nanoemulsion fluid are investigated. Water is added into PAO fluid to form nanoemulsion fluids in which dispersed water nanodroplets are formed by self-assembly.The liquid-to-vapor phase change results, expressed in terms of surface heat flux and heater temperature, have shown that the presence of water nanodroplets has a drastic impact on the liquid-to-vapor phase change behavior of the nanoemulsion fluid studied: the water nanodroplet formed inside can enhance its heat transfer coefficient by over 300% after the incipience of its phase change. In addition to that, the vaporization of the water nanodroplet inside is found to be different depending on the concentration of water inside, which happens to coincide with the structure change with different water concentrations as observed in SANS measurement. On the other hand, the effective specific heat is also found to increase with higher water concentration until reaching a maximum value which also happens to coincide with the structure transition from spherical to cylinder shape with the increasing of water concentrations as observed from SANS measurement. More study is still needed to understand the mechanism behind these phenomena.Copyright © 2014 by ASME


AbstractIn Western countries, development of sign bilingual programmes has typically occurred in educational contexts where aural/oral methods are already well established, and integration of deaf children into mainstream schooling is a predominant pattern. This paper discusses introduction of bilingual provision in a very different context. In China, although the last decade has seen rapid development of early intervention programmes for deaf children with provision of hearing aids and speech training, there are still many thousands of deaf children in segregated schooling, where sign-supported Chinese is used to teach the curriculum. In the context of a meeting to introduce concepts of sign bilingualism to deaf schools in Jiangsu Province, a survey was carried out of 22 Jiangsu deaf schools to ascertain basic characteristics of the student population and teaching staff. The results are presented here with their implications for the future development of different educational approaches: it is argued tha...


As program comprehension is a vast research area, it is necessary to get an overview of its rising and falling trends. We performed an n-gram frequency analysis on titles, abstracts and keywords of 1885 articles about program comprehension from the years 2000-2014. According to this analysis, the most rising trends are feature location and open source systems, the most falling ones are program slicing and legacy systems.


ABSTRACT The Franco-German Parliamentary Assembly (FGPA) set up in March 2019 is the result of an unprecedented collaboration between the parliaments of the two most powerful member states of the European Union (EU). While this bi-parliamentary assembly has received some attention by political think tanks, we know very little about its potential transformative effect on bilateral executive accountability as well as on the accountability and the salience of EU economic governance in the context of the COVID-19 pandemic. Based on an extensive document analysis and on semi-structured interviews with FGPA members and staff, we show that to a large extent the FGPA has become a forum of transnational accountability that cuts across the traditional domestic and EU channels of executive oversight. Our findings also reveal that the pandemic has increased the FGPA's oversight activity and allowed for the (re-)emergence of EMU matters on the shared parliamentary and executive agenda.


Fundus retinal vascular image has high medical diagnostic value. Its segmentation image can help assess diseases that cause retinopathy, such as cerebral small vessel disease, coronary artery disease, glaucoma, and diabetes. Classical encoder-decoder segmentation methods like Unet cannot extract subtle details as well in the retinal vessel due to its complex structure. In this paper, we propose an improved Unet algorithm based on dual convolutions and integrate MultiRes feature extraction module. The MultiRes module improves the feature learning ability of micro vessels, which can collect further subtle details. The dual convolutions module utilizes dual feature maps with varying scales and channels, exchanges feature information with each other, thus can capture retinal vasculatures with better performance. Experiment based on the DRIVE dataset indicates that the accuracy, sensitivity, specificity, AUC(area under curve), and Dice coefficient of the proposed model are 96.13%, 78.57%, 98.17%, 97.29% and 80.87%. Compared with the existing advanced algorithms, our proposed algorithm shows its effectiveness.


In addition to jaslanceosides B (1) and E (2), and jasminoside (3), a new secoiridoid glucoside, isojasminoside (4) was isolated from the leaves of Jasminum amplexicaule (Oleaceace). The structure of 4 was determined on the basis of spectral analysis and chemical reactions. Chemotaxonomy for some selected plants in Jasminum is also discussed.


What I offer here is already common knowledge among most translators and many who have thought about translation. My own practice is so long-standing, and I have had so voracious an appetite for the labor of translating as well as for reading the reflections of others on the subject, that I am not sure a single thought which follows is entirely original. I do think it useful, however, to consider poetic form from a translator's point of view, in order to speak not only of the elements of form but also of the transformations these must undergo in the process of translation. Considering such transformations eventually involves, in addition, a consideration of the psychology of form: given, say, the translator's strong impression that a certain formal element must be preserved, what can be concluded from this necessity about the meaning of the formal element itself, its gestural significance? I do not enter very far into this line of inquiry, but it lies behind most of the very practical reflections that make up this essay.