Beishan-Gansu Corridor region is located at the intersection of the plates of Tarim,North China,Kazakhstan,Siberia and Qaidam.During the Meso-Cenozoic,the region experienced movements of Indo-sinian,Yanshanian,Sichuanian,North China,Himalayan and Neotectonic,and over 20 medium-small size superimposed continental basins were formed.On the basis of analyzing the tectonis stress field,sediment-filling and structure-deformation,the general trending of tectonic evolution in the Meso-Cenozoic is summarized as three-time compressional uplifting and two-time extensional down-faulting.The different evolution of basins under the above mentioned setting can be divided into six stages according to characteristics of filled sediment.The sand bodies developed in down-faulted basins are favorable for uranium ore-formation as they are formed under humid paleoclimates,and rich in reducing matter.Therefore,the Lower-Middle Jurassic is selected as the main target horizon for sandstone-hosted uranium deposit,and the Lower Cretaceous as the minor one.Although the tectonic reactivation of the target horizon after its deposition was generally strong,the slopes formed in some basins could be favorable for the infiltration of uranium-and oxygen-bearing groundwater into sand bodies and form uranium deposits.According to the favorable sand bodies and tectonic reactivation,the northern parts of Chaoshui and Bayingobi basins are regarded as potential regions which are worthy of further exploration.


Aimed at the deficiency of the current models,the concepts of the endpoint,inner and boundary of linear object in traffic network were defined on the basis of basic theories of point-set topology at first,and a formalized model describing line-line topological relations in traffic network,LL9I model,was proposed accordingly.On the basis of analysis of the model,ten rules were put forward to exclude the insignificant line-line topological relations described by the model according to the physical meaning of linear object.Then the smallest set of line-line topological relations was proposed,six basic line-line topological relations were defined,and the exclusivity and perfectibility of the smallest set were proved.


It has long been known that, for many joint distributions, Kendall's τ and Spearman's ρ have different values, as they measure different aspects of the dependence structure. Although the classical inequalities between Kendall's τ and Spearman's ρ for pairs of random variables are given, the joint distributions which can attain the bounds between Kendall's τ and Spearman's ρ are difficult to find. We use the simulated annealing method to find the bounds for ρ in terms of τ and its corresponding joint distribution which can attain those bounds. Furthermore, using this same method, we find the improved bounds between τ and ρ, which is different from that given by Durbin and Stuart.


Introduction Knee osteoarthritis (OA) is increasingly prevalent in athletes of all ages, especially those who have sustained a prior injury (1,2). Multiple nonoperative treatment strategies exist to try to keep athletes with knee OA active (3). In recent years, intraarticular knee injections with both hyaluronic acid (HA) and platelet-rich plasma (PRP) have shown superior efficacy to either alone (4–11). HA is a nonsulfated glycosaminoglycan (GAG) in the cartilaginous extracellular matrix that has viscoelastic (lubricant), analgesic, and anabolic effects (12,13). HA can modulate inflammation because of the inhibition of matrix metalloproteinases and enhance proteoglycan and GAG synthesis in chondrocytes and synoviocytes (12,13). PRP releases growth factors and cytokines (such as transforming growth factor beta and platelet derived growth factor) and has been shown to reduce pain, reduce synovial inflammation, and induce chondrogenic properties of chondrocytes (14–17). Combination HA and PRP injections have been shown to suppress OA pathology-related cytokines and chemokines, slow OA cartilage breakdown, and decrease OA-related immune cells (7). Optimal HA and PRP formulations, when used in combination, have yet to be determined. There is an ongoing call for standardization of optimal PRP injectates (18,19), but this debate is outside the scope of this commentary. Rather, our attention will focus on the composition of the HA injectate (molecular weight, concentration of HA, presence of crosslinking) and how variations in HA product composition may affect clinical outcomeswhen combiningHAandPRP injections.


In recent years, the number of electric vehicles in China has continued to rise, and the charging network for electric vehicles has developed rapidly. This paper studies the development characteristics of the electric vehicle charging network business market and forms a charging network policy environment that includes national and local policies. Then, use policy tools and divide policy tools into supply, environment and demand. Finally, based on the policy influence from the perspective of policy tools, the corresponding development suggestions are put forward.


Objective To compare the effects of high-frequency electric cautery and Nd:YAG for dacryagogatresia. Methods 167 cases (207eyes) with dacryagogatresia were treated by endolacrimal Nd: YAG laser reconstruction. 169 cases(222eyes)with dacryagogatresia were treated with high-frequency electric cautery. All patients were followed up for 6-24 months. The curative effects of the both methods were compared.Results In the cases with the block of upper lacrimal passage, the cure rate was 88.68% in Nd: YAG group and 68.29% in high-frequency electric cautery group. In the cases with the block of lower lacrimal passage,the cure rate was 83.11% in Nd:YAG group and 86.11% in highfrequency electric cautery group. The difference of the cure rate in the cases with the block of lower lacrimal passage in the two groups was no statistic significance. Conclusion Nd:YAG is worthy for the treatment of dacryagogatresia.


Human being while living in tune with environment for development also destroyed nature by various activities. Due to this process there is problem of environmental degradation due to excess use of natural resources and generation of waste. Many scientific techniques such as incineration, biological processing etc. have been discovered for the treatment of waste and then dispose into the natural resources. The kitchen waste is one of the typical household's waste shows a major impact on municipalities for the treatment. Many techniques have been suggested for the treatment of the same, but most of them are not possible to use at local level. Therefore, it is very essential to use such a technique which will convert the waste into a useful byproduct. One of them is Effective Microorganism Technology which was utilized for treatment of different type of waste to convert them into useful byproduct.


ABSTRACT. This paper deals with the steady state behavior of single server retrial queue with modified Bernoulli vacations, where each type of service is voluntary service subject to breakdowns and repairs. In the system if there are no customers at the end of each service, while the next customer arrives, the server waits with probability 1-a and probability a, the server takes vacation. We construct the mathematical model and derive the stationary probability distribution number of customer in the system by using the supplementary variable method. Some system performance measures and special cases are obtained.


The tissue distribution of ampicillin entrapped in liposomes was studied in normal noninfected mice and showed that ampicillin concentrated mostly in the liver and spleen. Liposomate ampicillin was significantly more effective than free ampicillin in reducing splenic and hepatic bacterial counts in C57BL/Ka nude mice chronically infected with Listeria monocytogenes EGD. It was also significantly more effective than free ampicillin in reducing mortality in C57BL/6 mice acutely infected with Salmonella typhimurium C5. Comparison of the results with those previously obtained in the same experimental models with the same amounts of ampicillin bound to polyisohexylcyanoacrylate nanoparticles showed that liposomes were more effective than nanoparticles (M. Youssef, E. Fattal, M. J. Alonso, L. Roblot-Treupel, J. Sauzières, C. Tancrède, A. Omnès, P. Couvreur, and A. Andremont, Antimicrob. Agents Chemother. 32:1204-1207, 1988) in targeting ampicillin to the spleen but were less effective than nanoparticles in targeting ampicillin to the liver and reducing mortality in acute salmonellosis.


Laboratory tests were conducted to determine the feasibility of making the mosquito ovitrap lethal to Aedes aegypti (L.) when they attempt to oviposit in the trap. Heavy‐weight velour paper strips (2.54 × 11 cm) were used as an alternative to the wooden paddle normally provided as a substrate for mosquito oviposition. The paper strips were pretreated with insecticide solutions and allowed to dry before being used in oviposition cups of 473 ml capacity, filled with water initially to within 2.5 cm of the brim. Insecticides chosen for their quick knock‐down efficacy were bendiocarb 76% WP (1.06 mg a.i./strip) and four pyrethroids: permethrin 25% WP (0.16 mg a.i./strip), deltamethin 4.75% SC (0.87 mg a.i./strip), cypermethrin 40% WP (2.81 mg a.i./strip), and cyfluthrin 20% WP (0.57 mg a.i./strip).


For grasping the impact of reinforced fiber on swell-shrinking property and other mechanics performances of expansive soil,a great deal of indoor experiments are conducted to study various relationships among fiber content and other mechanics performances,i.e.swell-shrinking property,compressibility,stressstrain,and shearing strength.The study results show as follows: The swell-shrinking property apparently decreases with the increase of fiber content;the limiting strain will increase with the increase of fiber content,but the stress-drop will greatly decrease as the damage of the soil;fiber expansion soil's cohesion will increase but internal friction angle will decrease as the fiber content increase,but when the content is added to a certain extent,the former will decrease and the latter will increase.


Purpose To observe the effect of treatment with Liujie Tongluo Instrument on plasma atrial natriuretic factor (ANF) in the patient of primary hypertension. Methods 35 cases of primary hypertension were treated by the Liujie Tongluo Instrument for 14 days and the plasma ANF was determined by radioimmunoassay before and after treatment, and 16 healthy persons were used as controls. Results The levels of plasma ANF in the patient of primary hypertension were significantly higher than that in the control (P0.01); after treatment, the levels were decreased significantly (P0.01), and the systolic and diastolic pressures were significantly reduced (P0.01 or P0.05). Conclusion Liujie Tongluo Instrument is effective, safe and well tolerable for treatment of primary hypertension.


We place the first constraints on binary planets and exomoons from Doppler monitoring of directly imaged exoplanets. We model radial velocity observations of HR 8799 b, c, and d from Ruffio et al. and determine upper limits on the msini of short-period binary planets and satellites. At 95% confidence, we rule out companions orbiting the three planets more massive than msini=2 M J with orbital periods shorter than 5 days. We achieve our tightest constraints on moons orbiting HR 8799c, where with 95% confidence we rule out out edge-on Jupiter-mass companions in periods shorter than 5 days and edge-on half-Jupiter-mass moons in periods shorter than 1 day. These radial velocity observations come from spectra with resolution 20 times lower than typical radial velocity instruments and were taken using a spectrograph that was designed before the first directly imaged exoplanet was discovered. Similar data sets from new and upcoming instruments will probe significantly lower exomoon masses.


In this paper, we study a nonlinear first-order singularly perturbed Volterra integrodifferential equation with delay. This equation is discretized by the backward Euler for differential part and the composite numerical quadrature formula for integral part for which both an a priori and an a posteriori error analysis in the maximum norm are derived. Based on the a priori error bound and mesh equidistribution principle, we prove that there exists a mesh gives optimal first order convergence which is robust with respect to the perturbation parameter. The a posteriori error bound is used to choose a suitable monitor function and design a corresponding adaptive grid generation algorithm. Furthermore, we extend our presented adaptive grid algorithm to a class of second-order nonlinear singularly perturbed delay differential equations. Numerical results are provided to demonstrate the effectiveness of our presented monitor function. Meanwhile, it is shown that the standard arc-length monitor function is unsuitable for this type of singularly perturbed delay differential equations with a turning point. Mathematics subject classification: 65L05, 65L20, 65L50


Aims and objectives: This study aims to analyse the complete prole of patients diagnosed and treated as IDEM spinal
cord tumours. The factors studied include age, sex, clinical presentations, histopathology, surgical outcome and post
operative recurrence. It is a single center prospective study conducted over a peri Materials and method: od of 18 months. Patient
demographics, severity and duration of symptoms, and tumor characteristics (anatomical and pathological) in all operated spinal IDEM tumors
were collected. The neurological ndings obtained during the preoperative stage and the postoperative follow-up were evaluated according to
the Frankel and Nurick grading. The back pain was assessed with help of the Denis pain scale (DPS). Data collected throughout preoperative and
postoperative examination and investigations were analyzed and submitted to statistical procedures. Our study Results and analysis:
included30 patients, majority being young adults between 20 to 30 years (46.66%). The male and female ratio in our study was 2:1. Predominant
presentation was sensory symptoms like numbness, paraesthesia in extremeties (66.66%), followed by pain in back, limbs (33.33%). The most
common location found was dorsal cord (50%) followed by lumbar(36.66%). The histopathological examination showed meningioma to be the
most common (56.66%), followed by schwannoma (20%), and neurobroma (16.66%). Pseudomeningocoele was the only complication
encountered. Out of 30 patients we had operated, we could achieve total excision in 27 patients (90%). There was no postoperative worsening of
symptoms, and no recurrence. The clinical and pre and postoperative prole suggested Summary and Conclusion: IDEM spinal cord tumours
were common in 3rd decade, with male predominance. Commonest location was dorsal area with meningioma being the commonest
histopathological nding.


The sexuality of men with learning disabilities suggests that sexual health should be placed alongside consent to sex as a priority for sex education. This paper reviews HIV prevention and safer sex education work with men with learning disabilities, identifying considerations for responding to HIV in its third decade. While the effective targeting of HIV prevention remains with men with learning disabilities who have sex with men, new considerations are also emerging from experience with sex education, staff training and HIV prevention more widely, helping reshape and inform service responses and individual work.


ABSTRACT The mental load has received considerable public attention especially in the wake of the COVID-19 pandemic. In this article, we synthesize existing literature to argue that the mental load is a combination of cognitive and emotional labor and it is this combination that makes the mental work a load. We argue that the way the mental load operates within families and society has three characteristics: (1) it is invisible in that it is enacted internally yet results in a range of unpaid, physical labor; (2) it is boundaryless in that can be brought to work and into leisure and sleep time; and (3) enduring in that it is never complete because it is tied to caring for loved ones which is constant. We also offer some future directions for addressing the problems associated with the mental load. First, questions measuring the mental load should be standard in health and social surveys to better understand the problem. Second, employers should adopt better policies that allow for greater work-life reconciliation to lessen the mental load. Third, caregiving should be vital infrastructure developed and invested in by governments to reduce competing work and care demands that accelerate the deleterious consequences of the mental load.


According to AK growth models, permanent changes in investment rates have permanent effects on a country's rate of economic growth. Jones (Quarterly Journal of Economics, 1995, 110, 495-525) finds strong evidence against this prediction studying the time series properties of GDP growth rates and investment output ratios in fifteen OECD countries for the period 1950-1988. In this paper, we test the same hypothesis in four OECD countries using a longer span of data (1870-2002 for Canada, the UK and the US and 1885-2002 for Japan). Moreover, instead of using classic approaches, which are based on stationary I (0) or unit roots I (1) processes, we use methodologies based on fractional integration. After examining the order of integration of GDP growth rates and non-residential investment rations for these countries, we do not find much evidence against the "growth effects" prediction of AK models. In fact, we only find clear evidence against this theory for the UK case.


nificance, yet inside there is no detailed examination of its contents. What there is is perfunctory, forming part of wider discussions, such as a brief mention of the manner in which one of the characters, Jules, co-opts the derogatory and traditionally male 'wanker' sign in a wider analysis of gestures. Given that on release Bend It ... became the most successful film about football (or soccer) at the American box office, and is still in the top three, and that furthermore, it is one of the few films focused on women's sport to have achieved genuine global recognition, it seems an odd omission. This is even more the case given that Chare's final chapter is devoted in its entirety to Whip It, which, due to the similarity of its storyline, has drawn frequent comparison with its British counterpart. Both are rite-of-passage films focused on a teenage girl who discovers herself through her chosen sport. Yet there is a key difference; while Bliss, the protagonist in Whip It, is white, Jess, the protagonist in Bend It Like Beckham, is a Punjabi Shikh. A discussion regarding the representation of her intersecting social status would have had merit. Furthermore, it would have also been worth exploring whether the success of Bend It Like Beckham is due to the film's female-focused subject matter or, at least in part, its explicit link to a male sports star. Chare's argument that narrative is not the only manner in which a film's emancipatory message about sportswomen can be subverted or notions of patriarchy reinforced is valid and demands exploration. However, at times it feels this analysis comes at the cost of a full consideration of the narratives of the films in question. Again, given that the entire conclusion is devoted to Whip It, it seems odd that Chare glosses over (in just one sentence) the fact that the protagonist's right to follow her sporting dreams is ultimately conferred by her father, thereby subverting any notion of female empowerment that has developed up to that point, while devoting a whole section to the animal motifs which pepper the film.


The sheep tick Ixodes ricinus (L.) is known to transmit a large number of pathogens of medical and veterinary importance, including the bacterium Borrelia burgdorferi sensu lato, the causative agent of Lyme borreliosis. Ixodes ricinus is found predominantly in woodlands, which provide suitable hosts and microclimates for tick survival. Three blood meals from a wide array of possible hosts are needed to complete the tick life cycle within 2 to 6 years. Ticks can acquire B. burgdorferi s.l. during a blood meal on an infected host and can infect a new host during the next blood meal. In this thesis, interactions between hosts, habitat characteristics, and microorganisms in relation to the biology of I. ricinus were investigated. A longitudinal study that was initiated at 24 sites across The Netherlands revealed that ticks infested with B. burgdorferi s.l. were found at all sites, but with strong spatial and temporal variation. This variation could be partially attributed to habitat characteristics. Substantial variations in the bacterial diversity within I. ricinus nymphs were also observed between habitats. Molecular genetic analyses indicated the presence of several potentially pathogenic and non-pathogenic bacteria. The interactions of these bacteria with hosts, ticks and other micro-organisms that reside in the tick need to be established in the future. It is known that rodent populations can mediate B. burgdorferi s.l. circulation in nature. Therefore, we studied the potential effects of rodents on the spatial variation of Borrelia infections in host-seeking ticks. Wood mice (Apodemus sylvaticus) and bank voles (Myodes glareolus) were abundant at most sites, but had varying tick burdens and Borrelia-infection prevalence between sites. It is argued that the infection prevalence in host-seeking I. ricinus ticks in the vegetation depends on the degree of contact between ticks and mice, which is, in turn regulated by habitat characteristics. Larger hosts, such as ruminants, are important for tick reproduction. Because domestic cattle is frequently used in the management of forested areas in The Netherlands, the effect of such management on tick populations was addressed. Results from this thesis show that the presence of cattle in a woodland resulted in a locally reduced tick density, whereas Borrelia infection prevalence remained the same compared to ungrazed woodlands. The tick-reducing effect of cattle was attributed to the negative effect of cattle on rodent populations. Effects of other mechanisms such as habitat alteration by the cattle are arguable and require further study. A central issue in the ecology of Lyme borreliosis is the mechanism by which Borrelia species circulate between the life stages of ticks and their hosts. This circulation is strongly affected by the chance that the tick will find a host. It was found that that B. burgdorferi s.l.-infected I. ricinus nymphs displayed increased walking activity and had a greater resistance to desiccation than uninfected ticks. These Borrelia-mediated effects can contribute to increased chances of host finding by the tick, and thereby to an increased transmission of Borrelia species. In conclusion, Borrelia-infected ticks were present at all locations studied, but with a dynamic heterogeneity, which is partly influenced by habitat characteristics and rodent hosts. The introduction of large herbivores could become an advantageous management strategy to help reduce the incidence of Lyme borreliosis, and further experiments confirming the mechanisms underlying this relationship would be valuable. The established B. burgdorferi s.l.-mediated behavioural changes in I. ricinus contribute to the understanding of the ecology of Lyme borreliosis, and create opportunities for future studies on tick-parasite interactions.


Objective to explore potential association between LncRNA NONRATT021972 and TNF-αin diabetic rat models. Methods Streptozocin (STZ) was treated for SD adult male rats to establish diabetes model. 40 STZ-treated rats were randomly into two groups, and siRNA group received NONRATT021972 siRNA treatment, while the rest received saline treatment (D2M). 20 Normal rats were received saline treatment in Control group. Vein blood sampling was performed in 3 groups. Quantitative Real-time PCR was performed to examine expression of LncRNA NONRATT021972 and TNF-α in blood. Mechanical withdrawal threshold and the thermal withdrawal latency test were performed in1w, 2w, 3w, 4w later for 3 groups' rats. Results Compared with D2M group, blood samples in Control group and siRNA group contained significantly lower concentration of glucose and LncRNA NONRATT021972 (P<0.05) . Compared with D2M group, blood samples of 3 weeks later in Control group and siRNA group contained significantly lower concentration of TNF-α (P<0.05). Moreover, the concentration of TNF-αamong D2M rats was positively associated with LncRNA NONRATT021972. Compared with control group, D2M group showed decreased mechanical withdrawal threshold and the thermal withdrawal latency. Further experiment showed that inhibition of LncRNA NONRATT021972 by siRNA indeed alleviated neuropathic pain, verified by mechanical withdrawal threshold and the thermal withdrawal latency in siRNA group compared with D2M group. Conclusion LncRNA NONRATT021972 was increased in type 2 diabetes rat and was positively associated with TNF-α. LncRNA NONRATT021972 exacerbated neuropathic pain via glucose and TNF-α related pathways. Inhibition the gene was a therapeutic strategy.


A novel family of metallate compounds has been developed for use in catalyst systems for the ring-opening polymerization of dicyclopentadiene (DCPD) and other norbornene-type monomers. Examples of these novel catalyst compounds are the organoammonium isopoly-and heteropolymetallates. Applications of these metallates in combination with alkylaluminum-type reducing cocatalysts are found in the production of both solution polymers, and cross-linked resins from reaction injection molding (RIM). These catalyst systems have significant advantages over prior art catalysts. They are highly soluble in DCPD and other norbornene-type monomers, thus eliminating the need for a reaction solvent. They also are insensitive to air and moisture, have unlimited shelf-life in solution in norbornene-type monomers, and do not function as Lewis acids. The chemistry of these catalyst systems is discussed, along with the benefits they provide to the properties of the final polymer products. © 1993 John Wiley & Sons, Inc.


Introduction

Inhibitor development against infused FVIII is a serious complication in hemophilia A that greatly increases the risk of developing major bleeding episodes. Immune tolerance induction (ITI) is the standard therapy for the management and eradication of inhibitors and return to effective FVIII therapy. Little evidence exists on the long-term status of patients who eradicated the inhibitor totally or partially by ITI. Therefore, the aim of this study is to investigate the clinical status and sustainability of tolerance in patients who succeeded on ITI therapy.

Methods

The Long-term ITI study was an international, multicenter, observational, retrospective study performed on hemophilia A patients who received primary or rescue ITI therapy using a single pdFVIII/VWF concentrate (Fanhdi®, Grifols, Spain) and who showed partial or total success in the Grifols-ITI study (Oldenburg J et al. Haemophilia 2014;20:83, Rangarajan S et al. J Thromb Haemost 2013;11 suppl 2;1081). In the G-ITI study, 60 patients from Germany, Italy and Spain showed a success rate of 85% and nine other G-ITI patients from UK obtained a 78% of ITI success. Demographics and clinical data relevant for the Long-term ITI study were extracted from the medical records of eligible patients. Primary endpoints were to describe the long-term status and post-ITI outcomes (including comorbidities, joint status, bleeding episodes, inhibitor relapses, venous access complications, hospitalizations and surgeries). Secondary endpoints included regular hemophilia therapy as well adjuvant and concomitant therapy used. Statistical analysis performed was descriptive.

Results

Forty-four out of the 57 eligible patients signed the informed consent and were included in the study. The mean follow up period after ITI success was 9.3 ±3.3 years (range: 2.1-17.7). At least one co-morbidity was reported in 17 (38.6%) patients, which included liver and lung cancer, hypertension, liver disease, hepatitis C and HIV infection. Twenty-one (47.7%) patients had a total of 37 affected -joints of which 5 patients had 2 affected joints, 1 patient had 3 affected joints and 3 patients had 4 affected joints. In 38 (86.4%) patients at least 1 bleeding episode was reported (mean annual bleeding rate: 1.0±1.2; range 0.1-3.9). A total of 330 bleeding episodes were described, of which 271 were treated with Fanhdi. Four (9.0%) patients had inhibitor relapse. Of those, 2 patients did not attempt rescue ITI because in one case the inhibitor (0.5 BU) disappeared after the next infusion with Fanhdi, and the other was considered of low titer (3.5 BU). The 2 patients who attempted rescue ITI (one under prophylaxis with Kogenate and the other treated on demand with Emoclot at the time of inhibitor relapse) were both successfully tolerized, one completely after 3.9 months of ITI with Fanhdi and the other partially after 9.1 months of ITI with Haemate P. Twenty venous access complications were reported in 10 (22.7%) patients. Thirty-nine surgical/invasive procedures were reported in 22 (50.0%) patients, 37 procedures requiring extra treatment with FVIII (Fanhdi), 25 of them for more than 3 days and 14 for more than 5 days. Hospitalizations reported were 79, 17 of them due to bleeding, 18 due to venous access complications, 33 due to surgical/invasive procedures, and 11 due to other reasons. Treatment product for hemophilia after ITI success was always Fanhdi in 29 (65.9%) patients, while 13 (29.5%) other patients were first treated with Fanhdi and then switched to other FVIII products, and 2 patients were immediately switched post-ITI to other FVIII products. The most common regimen used was prophylaxis (42 patients, 95.4%), and the most common treatment frequency was every 48 hours (16 patients, 36.4%). The FVIII dose ranged from 20 to 85 IU/Kg. Use of NSAIDs was reported for 6 patients and immunesuppressors for 5 patients.

Conclusions

After an average of more than 9 years of post-ITI success follow up of patients participating in the G-ITI Study, all of them continue with regular FVIII treatment for hemophilia. The few inhibitor relapses were successfully overcome.

Disclosures Jimenez-Yuste: Baxter, Bayer, CSL-Behring, Grifols, Novo Nordisk, Octapharma and Pfizer: Consultancy, Honoraria, Research Funding, Speakers Bureau. Oldenburg: Baxter, Bayer, Biogen Idec, Biotest, CSL-Behring, Grifols, Novo Nordisk, Octapharma, Swedish Orphan Biovitrum and Pfizer: Consultancy, Honoraria, Research Funding, Speakers Bureau. Rangarajan: Baxter, Grifols, Biotest and Pfizer: Consultancy, Honoraria, Research Funding, Speakers Bureau. Peiro: Grifols: Employment. Santagostino: Bayer, Baxter, Pfizer, CSL Behring, Novo-Nordisk, Sobi/Biogen, Octapharma, Kedrion, Roche and Grifols: Consultancy, Honoraria, Research Funding, Speakers Bureau.


This paper gave an analysis on the comsuing behaviors of the urban residents during the periods of planning economy and system-changing,and put forward some ideas for the constructions of both policies and system.


The focus of this article is the comparative analysis of the usage of the Angular2 and Ember.js frameworks. The requirement for tests of these frameworks has been developed though special web applications. The analysis was performed with the following comparative criteria: the speed of the website generation, presentation of large amount of data, media services, security mechanism, documentation availability, different data format handling, and integration with social media. Also, this paper aims to present common features and differences between the two frameworks regarding their characteristic features.


The task of constructing a transmission has been provided to us by Digital Engineering, which is a company located in Hovmantorp. After meeting with Digital Engineering we started immediately with ...


This reasearch aimed to know the implementation of inclusive education toward
hyperactive students in elementary school of Muhammadiyah Alam Surya Mentari
Surakarta. The appearance of Inclusive Education for students with special needs
promotes the elementary school of Muhammadiyah Alam Surya Mentari Surakarta to
take part in supporting that program; it is done to support the children' right to be
educated. Among those special needs of inclusive students, one of them is called
hyperactive students. Students who move more active than the other students and
impulsive. If there is lack of handling, it will bother the process of study for them and
for the other students. The worst is that it will create a new problem inside like the
difficulty to get socialized and cannot achieve the best in academic. This research
used technique analysis data of qualitative research, case study. The data collecting
technique of this research are interview, observation and documentation. The
implementation of inclusive education in the elementary school of Muhammadiyah
Alam Surya Mentari Surakarta had been already good. The utilization of pull out
system is the evidence that there is conducted inclusive education in this school. By
that system, the students with special needs will be easier to learn the learning
materials. Especially for hyperactive students, it is proven by the fact that the
impulsive attitude of hyperactive students is getting reduced after given special
treatment from the inclusive division of the elementary school of
MuhammadiyahAlam Surya Mentari.


-4-(4-Chlorophenylazo)-1H-pyrazole-3,5-diamine reacted with ethyl acetoacetate, benzylidenemalononitrile, ethyl propiolate and malononitrile under microwave irradiation to afford pyrazolo[1,5-a]pyrimidine derivatives in high yields. The structures of compounds were confirmed by 1 H, 13 C NMR, MS, elemental analyses and X-ray crystallography.


Nanocellulose is attracting more and more interests as a nanoscale 1D additive in polymeric membranes due to its natural availability, high aspect ratio, tunable surface, and excellent mechanical properties. In this work, an effective way to modify nanocellulose fibril surfaces for performance enhancement in CO2 separation membranes has been demonstrated. The functionalization promptly triggered intrinsic property responses in favour of nanofiber dispersion and CO2 transport. Thin composite membranes containing the modified nanofibers in water-swelling polyvinyl alcohol (PVA) as well as in the blend of sterically-hindered polyallylamine (SHPAA) and PVA were fabricated and tested using humid gas permeation tests. Defect-free ultrathin (300 nm) hybrid selective layers containing evenly distributed nanofibers were successfully coated. The addition of nanocellulose exhibited enhanced CO2 permeance and CO2/N2 selectivity compared to the neat PVA membranes; CO2 permeance up to 652 GPU with a CO2/N2 selectivity of 41.3 were documented. Functionalization plays a clear role in the dispersion of nanocellulose fibrils in the SHPAA/PVA blend, increasing the steric stabilization and interface compatibility with the polymer matrix. The tuned interface with PEG groups act as sites for water clusters retention and increased CO2 solubility, thus creating fast diffusion pathways for CO2 transport.


We study the infrared optical absorption properties of ABA- and ABC-stacked graphene multilayers using the effective mass approximation. We calculate the optical absorption spectrum at various carrier densities, and find the characteristic features that identify the stacking types and the number of layers. We fully include the band parameters and discuss detailed features such as trigonal warping and electron–hole asymmetry.


Enhanced by the 2007-2009 global financial crisis, the discussion on the adequacy of today's risk management practices within the financial sector has become highly relevant. One important part of managing financial risks involves the calculation of so-called regulatory capital an institution needs to hold in order to safeguard against unexpected large losses. The more advanced capital calculation methods are based on the view that risk can be quantified through the assessment of specific characteristics of an appropriate probability distribution of potential losses. More precisely, for two of the three major risk classes the required capital level is such that the potential total annual loss within that risk class is expected to exceed this level on average only once in 1000 years. The present thesis is a contribution of mathematical research to financial risk management. It consists of a review together with four self-contained papers. The review provides an introduction to the field and motivates the results of the accompanying papers. The main mathematical methods used in these papers are methods from extreme value theory (EVT). Although the results are written with an emphasis on possible applications to financial risk management, they may be viewed in a broader framework and are not restricted to a particular field of application. In Paper A we discuss pitfalls an imprudent application of standard EVT methods to specific loss models may bring with it. In particular we emphasize that the accuracy of EVT-based high quantile estimation very much depends on the so-called second-order regular variation behavior of the underlying probability distributions. In Paper B we consider convergence rates for normalized quantiles. It turns out that the convergence is very slow for certain models relevant for practice. As a consequence, the amount of data needed in order for standard EVT-based estimators to deliver reasonable results may be unrealistically high and largely incompatible with today's situation for loss databases. The concept of so-called penultimate approximations seems promising in this respect.


Background/Objectives: Wide rang of DC motors speed and their easy control are responsible for their widespread operation in industry. The introduced speed control methods for DC motors have developed by knowing new methods in control theory. Methods/Statistical analysis: The proposed method has been simulated using the information of a DC machine with software MATLAB and the SIMULINK environment. Findings: The results of this study demonstrated that through using FLC method no change is of observed in responses and the time of achieving to ideal speed is very low but in the PID method contrary to FLC method the time of sitting is high. While FLC method have a high limit in the ability of ideal deletion in different conditions of motor operation and decreasing of achieving time to final responses. Applications/Improvements: In this research a DC motor speed has been controlled by using Fuzzy control. The effect of load changes, reference speed, and armature voltage have been considered in this controller


In various parts of Sub‐Saharan Africa, malaria is endemic in areas where rain‐fed agriculture implies seasonal mobility from villages to paddy fields. Contributing to the small but growing literature on livelihood and malaria, this article examines the ways in which social actors mobilise, combine and transform capitals on the household and community levels to obtain malaria treatment. It emphasises the structuring force of cultural capital and argues that farmers of the Kilombero Valley in Tanzania develop a remarkable resilience to malaria. However, in spite of all their efforts, the web of resilience they are able to create remains rather weak and should be strengthened through intersectoral collaboration between government and civil society organisations and innovative interventions.


V757 Centauri (= HD 120734) is an 8th magnitude, southern W Ursae Majoris-type eclipsing binary with a period of about eight hours showing two eclipses of fairly similar depths. A study of the ephemeris and a lightcurve analysis of this binary, based on photoelectric UBV observations, has recently been published by Cerruti (1979) and Cerruti and Sistero (1982). In the present paper we present spectrographic observations of V757 Cen obtained with sufficiently short exposure times as to ensure the resolution of the spectral lines of both components. As expected from the similar depths of the photoelectric light minima, V757 Cen is also a double-lined spectroscopic binary. A radial-velocity study of this binary system yields spectrographic orbital elements, which coupled with the known photometric orbital elements permit us to estimate the physical parameters of the binary components.


Conversion efficiency of energy is an important characteristic for the piezoelectric components. Electromechanical coupling coefficient (EMCC) is a basilic parameter, it can be used to denote the conversion efficiency of energy. But now, there are three kinds of definition about EMCC. In this paper, by a standard piezoelectric resonator, the common, the difference and the range of three definitions are analyzed. The result shows that the open-short circuit calculation method will have greater application.


In this study, the beam broadening effect on Doppler spectrum was investigated with theoretical derivation and numerical simulation. It is found that vertical wind may cause a beam broadening spectrum not in exact Gaussian shape. Moreover, the azimuth angle variation of the beam broadening spectral width in the presence of vertical wind is more significant than that in the absence of the vertical wind. The widths of the beam broadening spectra for oblique beams pointing in the opposite directions are different. Further, wind shear effect on the azimuth anisotropy of the beam broadening spectral width is also studied in this article. In the context of three‐dimensional wind field with vertical shear of horizontal wind, an analytic expression of the beam broadening spectral width is proposed. A comparison between the analytic expression and simulation result suggests that the expression is applicable in general.


111 unique structure, size and shape-dependent phenomena. Therefore, systematic directions for synthetic methods and an understanding of the mechanisms by which the structure, size and shape of the nanostructural material can be controlled are of particular interest. In this work, we report the controllable synthesis of ferric oxide nanostructural materials utilizing a simple hydrothermal method. We also examine the roles of parameters critical to the size and shape guiding processes and properties of the synthesized nanostructural materials. In a typical synthesis, added the ferric solution and additive to NaOH solution with various concentrations under vigorous magnetic stirring, and then transfer the mixture to a stainless steel autoclave. The products were characterized by XRD, SEM, TEM, ED, IR, TG-DTA, and SQUID. The XRD patterns of the as-prepared products were shown that, all of the peaks can be easily indexed as the rhombohedral α-Fe2O3. The SEM images indicate all products are composed of a large number of individual nanoparticles. The structure, size and shape of nanostructures could be control by adjusting hydrothermal conditions.


The main reasons for billets deviation in the walking beam furnace were analyzed,and a feasible solution was put forward.It provides a useful reference for related engineering technicians and first-line maintenance staff.


Alexander Davidovich Makatsaria – obstetrician-gynecologist and world-renowned specialist in clinical hemostasiology, Professor, Doctor of Medical Sciences, Academician of the Russian Academy of Sciences, Vice-president of the Russian Society of Obstetricians and Gynecologists is an Adjunct Professor of the University of Vienna (Austria). In March 2022, the Rector's Office and the Academic Council of the Medical University of Vienna extended the powers of A.D. Makatsariya until 2025.


At the post-mortem examination, in which I was very kindly assisted by Surgeon Stuart, M.S., I found the whole peritoneal cavity filled with yellow turbid fluid, apparently derived from the small intestines. The liver was deeply bile stained, but was otherwise normal, as also were the stomach, spleen, kidneys and bladder. The small intestines presented several deep ecchymoses, and in several places had a thin coating of lymph causing adhesion of adjacent coils. In the anterior surface of the lower part of the duodenum was an opening an inch in diameter, the margins regular and deeply congested. There was severe bruising of the neighbouring areolar tissue. There was no other rupture in the intestinal tract, the large intestine being in all respects normal. There was no rupture of the diaphragm, but I found about threequarters of a pint of blood-stained serum in each pleural cavity, with some masses of fibrinous lymph apparently quite recent. The thoracic organs presented nothinoy abnormal. There was no bruising of the abdominal parietes. The general physical development was extremely good, and the man's health during his two years of service had, as shown by his medical history, always been excellent. It would appear that for some reason in this case, general extravasation into the peritoneal cavity did not take place until the day after the accident; when it did, death rapidly ensued. Judging from the obscurity of the symptoms during life, and the dificulty of finding the seat of lesion after death, I do not thinlr any operative interference would have been possible.


Mercury has remained an "enigmatic body" among the terrestrial planets for more than three decades, caused by the paucity of data collected by the NASA Mariner 10 spacecraft in the Seventies. The recent flybys of the Discovery mission MESSENGER with Mercury updated our knowledge about this planet, in particular new areas of Mercury have been imaged, revealing structures never observed before. One new feature, a double-ring impact basin named Raditladi, soon appeared very interesting for the small number of craters detected either on its floor and its ejecta, suggesting a very young age. The peculiarity to have a very young age estimate in the case of such a large impact crater is the starting point for a deepen analysis on this structure. In this work we will show the result of the hydrocode simulations of the basin to be used to investigate the layering, at the basis of the age determination, and the impactor size.


This issue of GaBI Journal contains articles dealing with some very practical issues related to the evaluation, describing, and use of generic and biosimilar products. These issues include the uncertainty associated with extrapolating results of studies that used small, non-representative study populations, study sites, or product types. These problems are evident in the evaluation of three articles in this issue. Other articles illustrate difficulties evaluating published opinions without access to the original data upon which such opinions were based: the need to evaluate the possible effects of real or potential conflicts of interest; and the lack of consistent regulatory approaches to important, non-pharmaceutical chemicals.


Using the methods of literature review, investigation and logical analysis, this paper discussed the question how to catch the opportunity of constructing cultural power to promote the development of Chinese sports culture and investigated the good way of the development of Chinese sports cultural. For the current status of underdevelopment Chinese sports culture, the sports management department should improve the sports culture organization and management, formulate development planning and management practices, construct sports infrastructure, support the development of sports industry and vigorously carry out folk sports.


Effect of both positive and negative dc electric fields on the Al0.3Ga0.7N/GaN/Al0.3Ga0.7 N heterojnuctions based single quantum well is studied through the Stark shifted energy levels and resonance widths which are related to tunneling rates. The built-in electric field in the quantum well is calculated using the polarizations due to spontaneous and piezoelectric fields. The results show that a high positive electric field is needed for tunneling under positive electric field over come to negative direction of the built-in electric field. The tunneling under negative bias can take place at lower field since both the negative electric field and internal electric field are in the same direction.


This paper expatiates on the mechanisms of saving fuel and lowering smoke emissions of emulsified oil,and we have do applied research on fuel emulsified used in CY6102BQ diesel engine. The bench test of diesel engine indicates that it can save 11.3 percent fuel averagely .The road test indicates that diesel-engined vehicle can save 6.1 percent fuel and decrease the value of smoke intensity to 61.7 percent .It is proved that this clean fuel has environmental protection and generalization value.


In the present study, we report a surface plasmon resonance based fiber optic sensor for histamine detection utilizing molecular imprinted hydrogel as a sensing layer. The sensor works in the range 1–10 μM histamine concentration.


Exergy analysis and material balances are useful to describe resource use in different systems. In this study, three different sewerage systems are analyzed: a conventional system with biological nitrogen removal, a conventional system in combination with source separation of urine, and a treatment system with source separation of urine and feces. The influence of factors such as the size of the system, access to farmland, and concentration of collected urine is studied. The study shows that total exergy consumption is least for the system with source separation of urine and feces and greatest for the conventional wastewater treatment system. The primary difference results from the amount of methane gas that is produced by each alternative. Another conclusion is that a significant portion of exergy consumption in the source separation system is the transport and spreading of urine.


Systems integration (SI) in healthcare uses an enterprise application integration (EAI) or middleware layer to allow disjoint systems on various platforms to exchange information. Health Level 7 (HL7) is the communication exchange standard used in healthcare for this purpose. The message structure and usage of HL7 is standardized but the implementation of HL7 is widely customized to fit specific system, application, and site. Therefore, EAI is used to accomplish seamless integration by transforming and filtering messages, translating and mapping coded values, and distributing and gathering messages to and from different systems. Within healthcare IT, the number of integrated information systems (IS) has been increasing and multiple environments are being set up to support different types of testing, such as regression testing, upgrade testing, compliance testing, etc. The ability to support multiple independent test cycles simultaneously is critical to patient care because each integration testing is designed to replicate real scenarios and mitigate any changes that can potentially be introduced to a live environment. The role of a systems integrator has evolved from primarily developing interfaces to also managing interfaces in multiple environments. This paper introduces a more efficient way of managing various test environments in SI using an EAI.


the Court of Appeal was given an original jurisdiction co-ordinate with that of the High Court did not create any difficulty. " It merely produced the somewhat odd result that an applicant under section 10 could choose whether to make his application to a Divisional Court or to the Court of Appeal." To interpret section 10 as conferring an appellate jurisdiction would create difficulty. It would be a breach of the general principle that no appeal lay to the court in any criminal cause or matter. It would mean delay. And, it would mean there would be a difference between the law of England and Ireland on the one hand and Scotland on the other. Authority for this conclusion was to be found in R. v. Briarton Prison (Governor), ex p. Savarkar [1910] 2 K.B. 1056, where it was held that the Court of Appeal had an original jurisdiction under section 10, the three judges in that case doubting whether the court had a dual jurisdiction, both appellate and original. The only problem that may arise is, supposing De Demko» instead of appealing to the Court of Appeal after the refusal of relief by a Divisional Court, had made a fresh application for relief to the Court of Appeal, would the court have had jurisdiction to hear it ? The reasoning of Lord Reid would suggest the answer to be in the negative.


Adolescents need skills to acquire information and compare, analyze, transform, and experiment with knowledge. However, little research has been conducted on the content and pedagogical practices that are necessary to achieve these skills. This article seeks to contribute to this discussion because geography enables the attainment of the so-called higher-order thinking skills, and the progressive inquiry model provides suitable pedagogical practices. This study provides empirical evidence on the effects of the progressive inquiry teaching method and learning models on cognitive and affective learning outcomes. This paper focuses on learning outcomes among 253 Finnish middle and upper secondary school students. This comparison between different developmental stages reveals the effects of the teaching and learning methods in question. The results indicate that the progressive inquiry method improves cognitive learning results at both educational levels in the context of geography education. The research provides evidence that older students benefit more from the learning model. Additionally, the self-regulated learning skills that the students possess at the beginning of the course do not affect their cognitive learning outcomes. Progressive inquiry clearly enhances the motivation levels of middle school students; however, the effect on the motivation level was more ambiguous among the upper secondary students.


Based on the velocity gate walkoff jamming signal model,a method of anti-VGWO jamming was proposed in terms of wavelet decomposition.By way of wavelet decomposition of target Doppler returns,selecting the proper threshold,filtering the FM portion of gate walkoff and doing wavelet reconstruction and correction,the returns with eliminated jamming were obtained,by which,the moving target tracking and detecting was done.The simulation result shows that this method is feasible.


Abstract:
Borago officinalis is highly interesting amongst nutritional and medical source relate to its high composition of some useful phytochemical compound. It is great plants with bright blue star-shaped flowers present in most world regions and usually known as borage. The Borago phytochemical analysis showed the presence of alkaloids, tannins, flavonoids, phenolic acids, essential oil, vitamins and others. Borage is cultivated all over the world and used in traditional medicine as a demulcent, diuretic, emollient, tonic, expectorant, for the treatment of coughs, inflammation and swelling, and other diseases. In herbal medicine, Borage seed oil (BSO) has been utilized for many progressive illnesses as a treatment agent. The BSO compounds include p-simen-8-L, ?-caryophyllene, sesquiterpenes, monoterpenes, alpha-linoleic, gammalinoleic and linoleic acid. BSO is famed to be the richest vegetable origin of gamma (?)-linoleic acid (GLA). Borage officinalis possess different pharmacological properties including antinociceptive, antioxidant, radioprotective, memory improving, hepatoprotective, antinflammatory, and analgesic effects.


Nitrogen-doped zinc oxide (N:ZnO) films on glass substrates have been prepared by the reactive gas-timing rf magnetron sputtering of ZnO targets in a mixture of argon and nitrogen gases. Using this gas-timing technique, N:ZnO films were produced without any substrate heating. The nitrogen partial pressure during the sputtering process was periodically controlled by an on-off sequence. The structural and optical properties of the fabricated films were analyzed by X-ray diffraction (XRD) and optical absorption spectroscopy, respectively. The nitrogen composition of the N:ZnO films was quantified by X-ray photoelectron spectroscopy (XPS). In this study, we focused on investigating the effects of the nitrogen flow rate and the rf power on the structural properties, the nitrogen doping efficiency, and the optical band gap of N:ZnO films. A slight shift in the optical band gap to a higher energy was found when the nitrogen flow rate was increased or when the rf power was decreased. This coincides with an improvement in the crystallinity of the films. Gas-timing rf magnetron sputtering deposition is a simple method of fine-tuning material properties by slight modifications to the existing sputtering technique.


Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis. Previous studies have shown that the ability of murine embryonic stem (ES) cells to form teratocarcinomas in nude mice is substantially reduced following targeted inactivation of the VEGF gene. We sought to determine whether VEGF-/- ES cells' tumorigenic phenotype can be rescued by transfection with a mutant H-ras. VEGF-/- ES cells were transfected with expression vector which directs the constitutive synthesis of oncogenic Val-12 ras. Expression of ras protein was documented by Western blot analysis. We injected several clones with different levels of Val-12 ras expression in nude mice. In agreement with our earlier report, VEGF-/- ES cells formed much smaller tumors than control ES cells. However, none of the ras-expressing clones tested formed tumors larger than those derived from parental VEGF-/- cells. Thus, pluripotent cells such as ES cells are unable to compensate for the loss of VEGF even in the presence of a potent oncogenic stimulus such as mutant ras. These findings strengthen the hypothesis that VEGF-mediated angiogenesis is crucial for effective in vivo tumor growth.


Accumulation rates of microfossil associations are independent of each other and, in addition to percentages, give indispensable information about the significance of micropaleontological data. Marine diatoms reveal that coastal upwelling in the Zaire fan region was strong during glacial stages and weaker during interglacial stages. Oceanic upwelling was intense in stages 6 and 2 and at the stage 5d–5c transition but not in stage 4. The Benguela Current did not penetrate into the Gulf of Guinea during the last 220,000 years. The PhFD index, based on the contribution of freshwater diatoms and phytoliths, is a measure of aridity in equatorial Africa. The production in the low-salinity river plume was high in the most humid periods on land and low when the continent was arid. On the long term, nutrient supply of the Zaire River to the ocean was probably larger in humid than in arid periods. Periods of strong seasonal variability in river fluxes and coastal upwelling coincide with arid intervals, except in the very humid interval with strong seasonal contrasts 35,000–20,000 years B.P.


This study aims to determine and analyze the effect of capital intensity, profitability, and leverage on tax avoidance in companies listed on the Indonesia Stock Exchange in the property and real estate sector during 2019-2021. The research method used is quantitative and uses research variables including "Capital Intensity" (X1), "Leverage" (X2), and "Tax Avoidance" (Y). The sample of companies using purposive sampling method in this study obtained 22 property and real estate companies during the 2019-2021 period. The research data used is secondary data with a Structural Equation Modeling (SEM) approach based on Partial Least Squares (PLS). This study has results that show, a) p-value capital intensity on tax avoidance 0.014 < 0.05; c) p-value leverage on tax avoidance 0.003 > 0.05. Conclusion, capital intensity and leverage can significantly affect the increase in tax avoidance in property and real estate sector companies.
Keywords: Tax Avoidance, Capital Intensity, Leverage, Property and Real Estate


Emotional Intelligence amongst undergraduate university students at a Higher Education Institution in the Western Cape Globalisation has brought increased complexity to employers. In these firms service and value for money are mostly delivered through decentralised organisational models. Midlevel managers and frontline staff have become more empowered. Therefore, employers increasingly judge graduate quality by conceptual, operational and especially emotional competencies. Gardner (1983; 1991) reported that business-related graduate programmes focused primarily on indicators of individual competence such as logical and linguistic intelligence, with less attention being given to spatial, interpersonal and naturalist forms of intelligence. Later research reported increased calls from industry to make curricula more relevant to `today's global workplace' through improved instruction in communication, leadership, as well as intrapersonal and interpersonal skills (Cherniss 1999; Doria, Rozanski and Cohen, 2003; Jaeger 2003; Myers and Tucker 2005). Lately, Daniel Goleman's research on emotional intelligence as a predictor of work performance has emerged (Goleman 1998, 2000; Weisinger, 1998) and continues to be highly influential. The traditional approach by educationists, however, has been to focus on logical and linguistic intelligence. This view have been challenged by many studies recently where researchers are beginning to argue that interpersonal and intrapersonal competencies and Emotional Intelligence (EQ) may be more important for success. Educational institutions have traditionally focussed primarily on logical and linguistic intelligence, with less attention given to other types of intelligence. Yet many researchers are beginning to argue that intrapersonal and interpersonal competencies, or emotional intelligence, may be more important for success in life than logical or linguistic intelligence (Tucker, Sojka, Barone & McCarthy, 2000). Though the concept of emotional intelligence was first introduced in organizations, its relevance made the concept an inevitable concept of consideration in the educational sector too. Teaching emotional intelligence skills in schools is very important because it can positively affect academic achievement not only during the session they are taught, but in subsequent years as well (Elias, Brune, Butler, Blum & Schumler, 1997). According to Caruso, Mayer and Salovey (2002), emotional intelligence skills and knowledge can be developed and learned and it matters most in times of change. Emotional intelligence is an ability to recognize one"s own feeling and those of others, for motivating self as well as one"s relationship with others. Laabs" (1999) study of the climate of individual teacher"s classroom concluded that teachers who are more aware of how students feel in the classroom are better able to design a learning environment that suits students and better able to guide them towards success. Studies (e.g. Ediger, 1997; Parker, Summerfeldt, Hogan & Majeski 2004)) have shown that the acquisition of emotional intelligence skills can significantly contribute to positive thinking in students and increase their ability to concentrate for a long time. Gender differences in psychological well-being are important because of the many efforts being made in contemporary society to empower all individuals to achieve self-actualisation and utilise their full potential. In a post-feminist context this incorporates the idea of an "equal opportunities" society; yet social stereotypes still remain (Connors, 1990; Eagly, 1987; Turner & Sterk, 1994). Regarding race differences, Salovey, Mayer and Caruso (2002) indicated that it still has to be investigated whether EQ is culture bound. One hundred and fifty senior students (comprising of second and third year undergraduate students) completed a biographical questionnaire and the BarOn Emotional Quotient-Inventory questionnaire. The results indicate that there are statistically significant differences in total EQ based on gender and age, although there were no statistically significant differences based on race. Conclusions are drawn about the importance of emotional intelligence in students and recommendations for future research are provided.


The remote cooperation diagnosis approach based on multi-agents for substation is put forward. With the aid of the widely distributed artificial intelligent systems, which are connected by Internet or Intranet, the devices, supervisory control systems, diagnosis systems, researchers and users are closely related, though they are in the individual zones. So the equipments status and diagnosis decision information are transferred quickly among them, and the dynamic diagnosis net is constructed. The cooperation mechanism and the multi-experts cooperation diagnosis are discussed in detail on the base of system structure. The multi-experts remote cooperation can be realized through multi-agents cooperation. A simulation indicates that the multi-agents diagnosis system processes better adaptability, initiative, and efficient interactive diagnosis performance, and has a bright application. It is an effective way for remote substation fault diagnosis.


Misfit dislocations were conceived by Jan H. van der Merwe in 1949 (Frank, F. C., and van der Merwe, J. H. (1949). One-dimensional dislocations. I and II. Proc. Royal Soc. London. Series A. 198, 205-216 and 216-225), long before they were directly observed by transmission electron microscopy in the early sixties (Matthews, J. W. (1961). The observation of dislocations to accommodate the misfit between crystals with different lattice parameters. Phil. Mag. 6, 1347-1349; Delavignette, P., Tournier, J., and Amelinckx, S. (1961). Direct observation of dislocations due to epitaxy. Phil. Mag. 6, 1419-1420). Since then, their appreciation by the scientific community has evolved from being considered a drawback to being recognized as a challenging opportunity. However, taking full advantage of all their potential, sets out issues that despite being well established in semiconductor or metals, remain poorly understood in transition metal oxides. In this Perspective contribution, we select recent findings on misfit dislocations in La0.7Sr0.3MnO3 under compressive strain, to illustrate effects spanning a range of length scales, like the coupling between strain and defect chemistry in and around their cores, the impact of kinetics on the morphology of dislocated films, or the subtle sensitivity of oxide properties to dislocation strain fields.


In the last few years a lot of attention has been devoted to the study of W-algebras[1]. For recent update reviews see [2], [3] where extensive lists of references can befound.An interesting way to construct classical W-algebras isbythe zero-curvature method[4], [5], [6],[7] [8]. If one constraints an A


Accurate runoff forecasting plays a vital role in issuing timely flood warnings. Whereas, previous research has primarily focused on historical runoff and precipitation variability while disregarding other factors' influence. Additionally, the prediction process of most machine learning models is opaque, resulting in low interpretability of model predictions. Hence, this study develops an ensemble deep learning model to forecast runoff from three hydrological stations. Initially, time‐varying filtered based empirical mode decomposition is employed to decompose the runoff series into several internal mode functions (IMFs). Subsequently, the complexity of each IMF component is evaluated by the multi‐scale permutation entropy, and the IMFs are classified into high‐ and low‐frequency portions based on entropy values. Considering the high‐frequency portions still exhibit great volatility, robust local mean decomposition is adopted to perform secondary decomposition of the high‐frequency portions. Then, the meteorological variables processed by the Relief algorithm and variance inflation factor features are employed as inputs, the individual subsequences of secondary and preliminary decomposition as outputs to the bidirectional gated recurrent unit and extreme learning machine models. Random forests (RF) are introduced to nonlinear ensemble the individual predicted sub‐models to obtain the final prediction results. The proposed model outperforms other models in various evaluation metrics. Meanwhile, due to the opaque nature of machine learning models, shapley is employed to assess the contribution of each selected meteorological variable to the long‐term trend of runoff. The proposed model could serve as an essential reference for precise flood prediction and timely warning.


Nine leafs" poem parties of " the modern poetry drama turns" the theories melts to remit to the western modernismverse art with creative, is modern verse idea that 40's in China modern poetry that a successful breakthrough, it send with " nineleafs" poem close related also special content in oneself.


The leaching process of electricity catalysis zinc sulfide concentrate in FeCl_3-HCl-CaCl_2 system has been studied.The following effect factors on zinc leaching ratio are investigated: temperature,acidity,trough voltage and stirring-speed.In optimum condition,zinc leaching ratio could attain 95%,and more than 90% sulfide in ore could be recovered in the form of sulfur element.


The theoretical analysis of concepts «polycultural education», «multicultural education», «polyethnic education» is presented in the article. The currency of the question about the influence of polyethnic educational environment of a higher school on the development of a personality is discussed.


The content of antioxidative compounds was evaluated in frozen green asparagus produced with the traditional technology from the material blanched before freezing or with the modified technology from cooked asparagus. Compared with blanched asparagus, the product cooked before freezing contained more dry matter and polyphenols, similar amounts of beta-carotene, less carotenoids and vitamin C and its antioxidative activity was lower. During a 12-month storage at -20°C and -30°C a steady decrease in the level of the analysed constituents was observed in frozen products prepared for consumption. Compared with the raw material, asparagus prepared for consumption after the 12-month period of refrigerated storage contained 56-62% of vitamin C; 55-71% of polyphenols; 73-81% of beta-carotene; 74-89% of carotenoids while its antioxidative activity was reduced to 65-73%. In products obtained using the modified method the level of the analysed constituents was similar or a little higher than in the traditional products. Frozen products stored at -30°C were usually characterised with a higher content of analysed constituents and a higher level of the antioxidative activity in comparison with frozen asparagus stored at -20°C. Sensory quality of traditional frozen products slightly exceeded that of frozen products obtained using the modified method. The quality of products stored at -30°C was also better than that of products stored at -20°C.


The use of engineering drawings is common practice, in the development of mechanical systems, for product definition capture, exchange and archival purposes. The latter is crucial for the aerospace product development process, characterized by product lifecycles that can exceed 70 years. For many enterprises envisioning the replacement of traditional 2D engineering drawings with 3D annotated CAD models, it becomes necessary to redefine how to maintain product definition data over such a long period of time. This paper discusses the problems associated with the longterm archiving of 3D models annotated with geometric and dimensional tolerances, and other specifications, in light of aerospace requirements that include regulatory and legal aspects. Overviews of the various initiatives as well as possible avenues for solutions are highlighted. A potential archiving solution based on both Acrobat 3D PDF and STEP formats is


The laminated limestone,dike rock and tuff are associated in the upper part of Middle Permian Nuo Ribagaribao Formation in the Zhou Qiongmalu area,northern Qiangtang.The plots of Al-Fe-Mn triangle diagram show that two limestones lay in the area of hydrothermal sediments.The average ratio of Fe/Ti、(Fe+Mn)/Ti and Al/(Fe+Mn+Al) are 0.53,41.90 and 46.06,respectively;the rate of Ni /Co is less than 3.6 and U/Th is less than 1;These rocks are enriched in various degrees in metal elements(Co,Cu,Zn and Pb) and hydrothermal active elements(As,Sb and Ba).The rare earth elements distribution patterns of these rocks show weak negative δCe and δEu,and skew to the right.Besides,the Co,Ni,Fe in limestones and the volcanic rocks on Co/Y-P/Y,Ni/Y-P/Y and Fe/Y-P/Y are present well linear dependence.Above all,those characteristics show that the limestones of Middle Permian Nuo Ribagaribao Formation are hydrothermal sedimentation and are formed in the environment of back-arc basin.This discovery has some indication meaning to the research of the large-scale Pb,Zn geochemical anomaly and the further ore-prospecting work in the upstream of the Tuotuohe area.


Translation Studies, as a fledgling yet developing focus in humanities, has undertaken a move away from linguistic orientations and towards sociological concerns. Hence, there has been increasing research using Bourdieu's sociology as their framework. The current study is a quantitative research which uses Bourdieu's notion of capital in order to investigate the expected and received capitals of prospective and practicing Iranian translators, respectively. For that matter, a 24 item questionnaire instrument was adapted and used for data collection. The collected data was analyzed using a number of inferential statistical procedures including exploratory factor analysis, t-test, and one-way ANOVA. As for the participants, 225 practicing translators and 178 prospective translators took participated in this cross-sectional survey study. The results indicate that the expected capitals of prospective Iranian translators significantly differ from the received capitals of practicing Iranian translators. Moreover, the received capitals of male practicing translators were significantly higher than those of female translators based on their own perception. However, work experience did not prove to have a significant effect on the level of perception of capitals received by practicing translators.


This paper deals with the introduction of the satellite navigation into the train control system. That topic has been widely investigated in this last years. To meet the stringent requirements imposed by the railway community the use of an external augmentation and integrity monitoring network is highly recommended. The exploitation of the data acquired by the reference stations can be performed by using a differential approach or by using a double difference approach. In this contribution, we have performed a comparison between these two approaches in the railway domain in terms of both complexity and performances. We made use of real data acquired on field to compare the results achievable with the two techniques and we carried out the SWOT analysis for both of them.


cross the university sector, there is evidence which suggests that the academic careers of many women have not advanced despite their competence and their academic achievements. In general, women remain clustered at the lower levels of academia, although there is a wide variation between the traditionally female disciplines such as the humanities, health, education and the traditionally male disciplines of engineering, architecture and agriculture. 1


Graffiti, by definition, has to be illegal. Its criminality stems from a public perception of violated property rights and of damage to neighbourhood image or place identity. However, artists see their work as improvements to existing environments rather than as dilapidation or destruction of place. Works tend to be done on public spaces and ommons which are interpreted by the artists as unfinished and free for expression. Albeit an arguably trivial crime, graffiti affects, for better or worse, environments which may be shared by millions. Accordingly, graffiti products are high profile, controversial, and of ongoing concern to urban policy makers. This response presents the arguments for and against eradication, tolerance, and protection of graffiti in the public realm.


Paediatric apheresis (PA) has distinct characteristics compared to adult apheresis and requires specialized knowledge and experience to perform safely, particularly in low‐weight patients. As evidence‐based medicine advances the field of therapeutic apheresis, increased attention must be paid to paediatric patients with conditions for which apheresis is indicated.


Abstract In the present paper we prove that every finite dimensional non-atomic measure ν is open and monotone (viz. ν–1 preserves connected sets) relative to the usual Fréchet-Nikodým topology on its domain and the relative topology on its range. An arbitrary finite dimensional measure is found on the other hand to be biquotient. Given a vector measure ν, we further investigate the properties of its integral map Tν: φ → ∫ φdν defined on the set of functions φ in L1(|ν|) for which φ(s) ∈ [0,1] |ν|-almost everywhere. When ν is finite dimensional, Tν is found to be always open. In general, when Tν is open, the set of extreme points of the closed convex hull of the range of ν is proved to be closed, and when ν and Tν are both open, the range of ν in itself is closed.


Purpose

As is the case of all organizations, the academic library is a body reflecting the contribution of its core employees. As such, the roles performed by academic librarians are crucial to its development and existence. The purpose of this paper is to explore the role of academic librarians as change champions in an information age that has been, still is, and is expected to be continuously pervaded by varying and widespread changes in librarianship and scholarship coupled with the ever changing and expanding user needs and expectations. The paper also identifies a framework to perform this role.

Design/methodology/approach

This paper is informed by opinion and draws on relevant literature to highlight the current climate and what is being perceived as valuable to the future direction of academic libraries in order to bring credence to its trajectory.

Findings

Academic librarians must readily accept, be responsive to, and anticipate change to maintain and justify their relevance to stakeholders. Yet, anecdotal evidence suggests that not all librarians are prepared to embrace change.

Practical implications

Academic librarians must understand how their roles influence the decision-making processes of the stakeholders and vice versa.

Originality/value

The paper advances five principles or 5As to guide the change process in academic libraries: alignment, accountability, agility, accessibility, and assessment. Very briefly, it discusses the relevance of a concept referred to as the competition-collaboration continuum to further academic librarianship. These notions serve to assist academic librarians in determining the appropriate actions to be taken now.


Genetic transformation system of Gladiolus cv.'Advanced Red' was established based on the regeneration system of embryogenic callus.Several factors were studied such as concentration of the infection,infection time,acetosyringone(AS) concentration,negative pressure and screening methods for genetic transformation of Gladiolus mediated by agrobac-terium tumefaciens(GV3101).The results showed that the highest rate of genetic transformation was obtained under the conditions of non pre-incubation,negative pressure treatment,agrobacterium concentration OD600 = 0.6-0.8,infection time 15-20 min,adding 100 μmol/LAS and 3 ds incuabtion.Following incubation for 3-4 months,the analysis of the resistant plants with PCR and southern blot indicated that the gus had been integrated into the genome of Gladiolus.


This research was conducted in the city of Machala, the capital of El Oro province. This research was aimed to determine the feasibility of a business for processing and marketing of dried fruit snacks in Machala city. Global consumption trends revolve around products and services that provide healthier living standards. Additionally the rise of nutritious food easily accessible, easy to use and low price are taking the markets. Processing technologies and food preservation have helped to generate a variety of products that make use of highly perishable food such as fruits and vegetables easier and more practical. This research showed that there is a niche market for the consumption of dried fruit snacks, potential consumers would be concentrated in the centers of secondary education in the urban area of Machala city. The technical feasibility studies determined the location of the enterprise in the industrial development of Machala where there are facilities to rent warehouses for processing various agribusiness products. The capacity production is based on the effective demand of the product offered, ie 200 kg / day of dried fruit, the product is a combination of papaya, banana, mango, macadamia nuts, raisins and peanuts salted in polypropylene bags with stamp and company brand containing 75 g of product in each bag. The production technology is craft and follow the regulations proposed by FAO for this activity. The financial feasibility studies indicate that entrepreneurship is feasible to perform. The results of the economic and financial evaluation indicate that the investment is likely to perform.


Thermal analysis has been utilized in polymer research for a long time and its usefulness is widely recognized. High-performance commercial instruments have driven significant progress in the thermal studies of polymers. On the other hand, new experimental instruments have been developed in laboratories as well. In this paper attention is paid to the latter category. The laboratory-made instrument focused on the target material and/or phenomena provides data that are not available from other techniques. Experiments using the temperature modulation technique, which has been successfully utilized in laboratory-made instruments, are introduced in this paper. The temperature modulation technique reveals a new aspect of temperature useful for studies of material properties. © 2016 Society of Chemical Industry


A parallel scan forward looking infrared (FLIR) with a digital scan converter (DSC) electronically reformats parallel input analog data into serial digital output data. This digital data can be supplied directly to a subsystem for further processing. Prior to returning to the analog domain to create the video image, the digital data passes through a line-to-line interpolation operator, gamma correction look up table and a histogram processor. Because of the video processing, the characteristics of the analog signal different than the digital signal. Line-to-line interpolation can provide √2 signal-to-noise (SNR) improvement. Frame integration, depending upon the scheme used provides additional improvement to the SNR. Clearly, the video image may not be representative of what actual signals are being supplied to the subsystem. Since the characteristics are different, it is essential to measure the system intensity transfer function (SITF), and noise equivalent temperature difference (NEDT) in both the analog and digital domains. Appropriate digital data display (histogram of values) permits easy assessment of data quality. Examples of missing data bits (dead lines) are shown. Lower order missing bits can affect a subsystem but the effect is minimized on the display due to the line-to-line interpolation scheme. The NEDT, SITF and noise spectral density in the digital and analog domains are compared. The implications of the difference in both domains are discussed.


The Permanent Committee of the International Health Office, Paris, held its ordinary session for 1938 last October, when questions on the application and interpretation of the various international sanitary Conventions were discussed at the plenary sessions of the committee and at the meetings of the various commissions. The following is an outline of some of the principal features of the report. Air Navigation


The purpose of this article is to critique human resource development's (HRD) dominant philosophy, practices, and research; illustrate how they negatively affect women HRD practitioners and recipients; and recommend alternative conceptualizations of the field. This article is grounded in a critical feminist theoretical framework, draws on critical theory and critical management studies, and is inspired by the author's ongoing disenchantment HRD's overreliance on "performative" ideas and practices.


Objective: We hypothesize that in women experiencing obesity and PCOS, the women with higher levels of free androgen index will display more dysregulation in the insulin signaling pathway in adipose tissue. More specifically, we believe that visceral more than subcutaneous adipose tissue in the women in the study will display more dysregulation; and lastly that bariatric surgery will alleviate insulin signaling dysregulation.
 Methods: Here, we performed molecular analyses (Western blots and qPRC) exploring the insulin signaling pathway in visceral and subcutaneous (SubQ) adipose tissue from women with obesity and PCOS undergoing RYGB bariatric surgery; and SubQ WAT from women with obesity and PCOS at baseline and six-months after medical intervention with metformin (MTF) .
 Results: Subcutaneous (SubQ) white adipose tissue (WAT) displayed a trending (p=0.2) but non-significant increase in p-ACC compared to visceral WAT from women with PCOS and obesity pre-bariatric surgery. Six months of MTF increased p-ACC in SubQ WAT by 5-fold compared to zero months (baseline) in women with PCOS and obesity. IR displayed similar expression in the visceral compared to SubQ WAT in women with PCOS and obesity pre-bariatric surgery. IR expression increased by 20-fold at 6-months of MTF compared to baseline in SubQ WAT of women with PCOS and obesity. Phosphorylated forkhead box 01 (p-FOXO1) displayed similar expression in the visceral compared to SubQ WAT in women with PCOS and obesity. However, p-FOXO1 was decreased at 6-months of MTF compared to baseline in women with PCOS and obesity. p-AKT levels were similar in visceral compared to SubQ WAT in women with PCOS and obesity pre-bariatric surgery. However, p-AKT levels were significantly increased by 4-fold at 6-months of MTF compared to 0-months in women with PCOS and obesity.
 Conclusion: None of the insulin signaling intermediates measured were altered in visceral compared to SubQ in women with obesity and PCOS.

 S. Andrisse: None.


The Gambia, 'The smiling Coast' of Africa, is a strip of low lying country located between latitudes 13o 00' and 13o 50' N and longitudes 16o 50' and 13o 45' W, with a total land boundary of 740 km, and dense population of 1,857,181. The two distinct climates are the rainy and dry seasons. The dry season which lasts from October till May is characterized by dry dusty wind; while the wet season lasts from June till early October, with total annual rainfall that varies from the coastline inwards. Based on the rainfall pattern, the three major agroecological zones include Sahelian, Sudan-Sahelian and Sudan-Guinean which favour the cultivation of some cash crops, food crops, and herbal plants. Foods, in the form of liquid or solid, are sources of nutrition and medicine for good health; malnutrition, or poison. Foods and nutrition are essential for maintaining good health and preventing disease. Not only is malnutrition prevalent in The Gambia, but most of the populace also seemed unaware of the content, quality, composition, the nutritive, or medicinal value of the foods consumed. In this review, the chemical, medicinal, and nutritive values of some commonly consumed or traditional foods and drinks and the names of some herbal plants and their uses in The Gambia are reported.


Interestingly, today (March 19, 2016), Richard, as I readied to write this letter to you, and as is usually the case, I hit an unknown button on my laptop by accident and found myself in a longforgotten folder. Curious about "tasks" from the past, I opened one and found a familiar signature line: /rr/, your signature line to a friendly reminder to get our department Anthropology and Education Quarterly (AEQ) team reviews to you as soon as we could while also noting that it was spring break. It was as a new faculty member of this review team along with a cohort of doctoral students that I was invited by two of the best, you and your compadre, Dr. Luis Moll, to engage as a group of colleagues (faculty and students alike) as manuscript reviewers. Still getting accustomed to the title of "Dr.," I recall a sincere appreciation for this unassuming but welcoming gesture from you, Richard. Moreover, this trip back in time surfaced a reflective moment that it was also your unassuming nature to blur the titles of faculty and students so that important collaborative and mentoring work could be accomplished. Other memories surfaced. Another welcoming gesture involved your reach back in time to your childhood in the Phoenix area. Aware of my cultural heritage of Hopi, you shared that your family lived next door to a Hopi family and that it was a child member of this family and your playmate who taught you to speak English. In the next breath, however, accompanied by a facial expression of clear distaste, you nonchalantly stated, "I don't like piiki," referring to the traditional Hopi waferthin blue corn bread—end of conversation. These memories are endearing and make me smile and reassure me that you are still present. You remain present in the fact that provocative questions you raised in seemingly casual faculty conversations and in student dissertation defense discussions continue to resonate for me. At one dissertation defense, you posed a question to a student in this way: "Let me ask you: When do you think a child begins to think critically?" This question opened the floodgates for me. I recall my own excited response; something to the effect of: "In Hopi society, I would say, a child begins critically thinking very early. I use the example of storytelling from my own childhood memories. During the winter months when Mother Earth is resting, families would come together for an evening with a village storyteller. The environment was conducive to creating wonder—the dark of night, a warm fire burning, parched corn (the Hopi version of popcorn) in yucca baskets for all to enjoy. When the evening ended, there was much to ponder when the ending of the story was not provided. I believe children were provided with the opportunity to engage in musing about the ending and the myriad possibilities of an ending that could be imagined long after the story had been told. I would say this setting provided the conditions for children who were present to engage in the process of critical thinking." I have thanked you over and over again for this revelation into the critical thinking process of young children and particularly for the prospect of privileging aspects of Indigenous education and the significance of Indigenous oral tradition as a critical cognitive developmental mechanism. What will also resonate for me from here on, Richard, is your chapter—chapter 10—entitled, "The Empowerment of Language-Minority Students," in Christine Sleeter's, Empowerment Through Multicultural Education (Ruiz, 1991). In this chapter, you distinguish clearly between language and voice: Language, being "general, abstract, subject to arbitrary normalization ... has a life of its own—


The Central Bank of Brazil is an autarchy of the federal government that checks the monopoly on currency distribution. In the majority of developed countries, the central bank is privately owned. However, in Brazil and in other countries with slow development, the central bank is public. Nevertheless, public central banks operate in practically the same way that private banks do, especially in regards to currency distribution, which, by means of legal devices, is a private monopoly almost all over the world. The goal of this paper is to analyze the public- private dichotomy, starting with an analysis of the legal safeguards of currency distribution in Brazil. On that point, we conclude that the evidence indicates that the degree of independence that the Central Bank of Brazil has acquired is linked to lobbies won by economic elites, who benefit from public debt titles, over political elites.


for an Invited Paper for the MAR11 Meeting of The American Physical Society Femtosecond magnetism and spin manipulation on a time-scale of the exchange interaction ALEXEY KIMEL, Radboud University Nijmegen The dynamics of phase transformations on the time-scale pertinent to atomic, orbital and spin motion is a rather unexplored field in physics. This is also a particularly interesting problem of modern magnetism, a study of which may have tremendous consequences for future development of magnetic recording technology. However, generation of magnetic field pulses much shorter than 100 ps and strong enough to reverse magnetization (more than 1T) is an extremely challenging technical problem.As a result the dynamics of the magnetic phase transitions at the sub-100 ps time-scale remains to be one of the most intriguing areas of modern magnetism [1,2]. Recently it has been observed that a 40 fs laser pulse influences spins in a magnet as an equally short pulse of effective magnetic field with a strength up to 20 T [3,4]. In my talk I will discuss how these opto-magnetic pulses can be used to excite a magnet on a time-scale of the exchange interaction between the spins [5-7]. Novel insights into the physics of non-equilibrium magnetism will be provided, showing that two exchange-coupled magnetic sublattices of a ferrimagnet may have totally different spin dynamics [8]. As a result, ultrafast spin reversal of two antiferromagnetically coupled magnetic sub-lattices appears to proceed via a novel ferromagnet-like transient state. [1] J. Stöhr and H. C. Siegmann, Magnetism: from fundamentals to nanoscale dynamics (Springer, Berlin, 2006). [2] A. Kirilyuk, A. V. Kimel, Th. Rasing, Rev. Mod. Phys. 82 2731 (2010). [3] A. V. Kimel et al, Nature 435 655 (2005) [4] C. D. Stanciu et al, Phys. Rev. Lett. 99, 047601 (2007). [5] K. Vahaplar et al Phys. Rev. Lett. 103, 117201 (2009). [6] A.V. Kimel et al, Nature-Physics 5 727 (2009). [7] A. H. M. Reid et al Phys. Rev. Lett.105 107402 (2010). [8] I. Radu et al (submitted).


rier that prevents membrane proteins from passing from the outer nuclear membrane to the inner nuclear membrane [Busayavalasa et al., 2012]. Fourth, the channel NUPs, NUP62, NUP58 (alias NUPL1), and its splice variants NUP45 and NUP54, constitute the innermost cylinder of the NPC. NUP54/NUP58 are thought to form a midplane ring that undergoes reversible expansion and contraction to regulate nucleocytoplasmic traffic [Solmaz et al., 2011]. Fifth, the nuclear basket NUPs, NUP153, TPR, and NUP50, which are involved in nuclear import/ export processes [Wälde and Kehlenbach, 2010]. Specifically, NUP153 and NUP50 form a ring, which facilitates nucleocytoplasmic transport [Hoelz et al., 2011]. The NUP50 protein is highly mobile and its dynamics depends upon active RNA polymerase II-mediated transcription. In addition, depletion of Nup50 inhibits differentiation of myoblasts into myotubes [Buchwalter et al., 2014]. Sixth, the cytoplasmic filaments emerging from the NPC are composed of 7 proteins, RANBP2 (alias NUP358), NUP214, NUP98, NUP88, ALADIN, NUPL2 (alias hCG1), and RAE1, and provide interaction sites for the nucleocytoplasmic transport [Hoelz et al., 2011]. Two other members of the NPC, the mRNA export factor GLE1 and the DEAD-box-containing RNA helicase DDX19, are involved in mRNA trafficking. Some NUPs have been related to immune disease, viral infections, and malignant disease [Nofrini et al., 2016]. Since the NUPs perform in concert essential functions, which are pivotal to the functioning of each body cell, it is difficult to conceive that germline mutations in the genes encoding NUPs may be compatible with life. NevIn each eukaryotic cell, the nucleus is surrounded by the nuclear envelope (NE) in which the nuclear pore complex (NPC) is embedded. In vertebrates, the NPC is roughly 60 Mda in size and comprises approximately 30 distinct proteins. The NPC forms an octagonal channel across the NE and functions in nucleocytoplasmic transport, maintaining the nuclear framework, and regulation of gene expression [Nofrini et al., 2016]. The number of NPCs per nucleus varies with environmental conditions and cellular activity, such that it increases during interphase and reaches a peak during the S-phase of the cell cycle. The NPC is formed by the nucleoporins (NUPs) and consists of 4 concentric cylinders, which surround an inner channel of 40–50 nm in diameter. NUPs are named after their molecular weight and fall into 6 main categories [Hoelz et al., 2011]. First, the transmembrane NUPs, NUP210, NDC1, and POM121, which are integral membrane proteins. They are thought to participate in NPC assembly and anchoring to the NE. Second, the membrane-apposed coat NUPs, which include NUP160, NUP133, NUP107, NUP96, NUP85, SEH1L, NUP43, NUP37, and SEC13. They form the nonameric Nup107– 160 complex that is required for early steps in NPC assembly. The ELYS protein is thought to be the tenth member of this Nup107–160 complex. Third, the adapter NUPs, NUP205, NUP188, NUP155, NUP93, and NUP35, which constitute the NUP93 complex. NUP188 and NUP93 control the organization of the subcompartments of the NE, such as the outer nuclear membrane, which is contiguous with the endoplasmic reticulum, and the inner nuclear membrane. NUP188 and NUP93 form a barAccepted: February 11, 2020 Published online: February 15, 2020