The religious opposition of Tolstoy and Dostoevsky was formalized (or even created) and was significantly widened in the works of Russian religious philosophy. The almost unconditional acceptance (or at least sympathy) for Dostoevsky's religiosity, along with distrust and well-known criticism of Tolstoy's later religious works, was firmly entrenched in the Orthodox and general cultural consciousness for more than a century. However, the confrontation was never taken seriously. We want to outline the insurmountable chasm between two images of finding God using the example of the relationship between Raskolnikov and Sonya Marmeladova on the one hand, and Father Sergius (Stepan Kasatsky) and Pashenka (Praskovya Mikhailovna) on the other. These examples are of a paradigmatic nature and can be extended to other artistic and religious (in Dostoevsky's case, journalistic) works of Dostoevsky and Tolstoy. From the legacy of Russian religious philosophy for the consideration of the works selected in the article ("Crime and Punishment" and "Father Sergius"), Bulgakov's "The Man-God and the Man-Beast" has the greatest and characteristic value. The opposition set by Bulgakov between Tolstoy (using the example of later works) and Dostoevsky (using the figure of the elder Zosima) is considered a misunderstanding by us. Bulgakov biasedly understands the religious meaning of Tolstoy's later texts. We offer a different reading of "Father Sergius" and raise the question of different images of the attainment (finding) of God in the texts of Tolstoy and Dostoevsky anew.


With the global population aging rapidly, Alzheimer's disease (AD) is particularly prominent in older adults, which has an insidious onset and leads to a gradual, irreversible deterioration in cognitive domains (memory, communication, etc.). Speech-based AD detection opens up the possibility of widespread screening and timely disease intervention. Recent advances in pre-trained models motivate AD detection modeling to shift from low-level features to high-level representations. This paper presents several efficient methods to extract better AD-related cues from high-level acoustic and linguistic features. Based on these features, the paper also proposes a novel task-oriented approach by modeling the relationship between the participants' description and the cognitive task. Experiments are carried out on the ADReSS dataset in a binary classification setup, and models are evaluated on the unseen test set. Results and comparison with recent literature demonstrate the efficiency and superior performance of proposed acoustic, linguistic and task-oriented methods. The findings also show the importance of semantic and syntactic information, and feasibility of automation and generalization with the promising audio-only and task-oriented methods for the AD detection task.


A battery of tests was used to determine the effects of three dilute mercuric chloride solutions on larval stages (Zoea I, III, V) of the fiddler crab Uca pugilator (Bosc). The influence of both acute and chronic exposures on viability, oxygen consumption, and swimming activity was measured. No stage V and only a few stage I or III larvae were able to survive a concentration of 9 * 10-7 M HgCl2 (0.18 ppm Hg) longer than 24 hr; an exposure as short as 6 hr resulted in reduced metabolism and swimming rate of all stages. Although concentrations of 9 * 10-9 M HgCl2 (0.0018 ppm) and 9 10-11 M HgCl2 (0.000018 ppm) were sublethal, 24-hr exposures did affect metabolism and swimming. Some larvae reared in the more dilute mercury solutions developed to the megalopa stage, but survival was reduced in relation to the mercury concentration. The data from all tests suggest that toxicity of mercury increases with larval age.


Recent progress in flexible sensors and piezoelectric materials has enabled the development of continuous monitoring systems for human physiological signals as wearable and implantable medical devices. However, their non‐degradable characteristics also lead to the generation of a significant amount of non‐decomposable electronic waste (e‐waste) and necessitate a secondary surgery for implant removal. Herein, a flexible and biodegradable piezoelectric material for wearable and implantable devices that addresses the problem of secondary surgery and e‐waste while providing a high‐performance platform for continuous and seamless monitoring of human physiological signals and tactile stimuli is provided. The novel composition of bioresorbable poly(l‐lactide) and glycine leads to flexible piezoelectric devices for non‐invasive measurement of artery pulse signals in near‐surface arteries and slight movement of the muscle, including the trachea, esophagus, and movements of joints. The complete degradability of piezoelectric film in phosphate‐buffered saline at 37 °C is also shown. The developed pressure sensor exhibits high sensitivity of 13.2 mV kPa−1 with a response time of 10 ms and shows good mechanical stability. This piezoelectric material has comparable performance to commonly used non‐degradable piezoelectric materials for measuring physiological signals. It can also be used in temporary implantable medical devices for monitoring due to its degradable nature.


This paper is concerned with globally asymptotical synchronization of fractional-order memristor-based neural networks (FMNNs) with multiple time-varying delays. Based on the definition of memristors, a more practical model of FMNNs with multiple time-varying delays is constructed from the integerorder counterparts. FMNNs are represented by fractional-order differential equations with discontinuous right-hand sides, which makes traditional definition of solutions for fractional-order differential equations inapplicable to FMNNs. This problem is handled with the theory of Filippov solutions. By combining state feedback control with adaptive control, a novel and simple adaptive feedback controller is designed to make two FMNNs achieve globally asymptotical synchronization. By constructing a suitable Lyapunov function, globally asymptotical stability of the controlled synchronization error system can be guaranteed theoretically. Finally, a numerical example is given to illustrate the effectiveness of the designed controller.


After Dryden's dramatic reversal of fortunes in 1688-loss of royal patronage, effective banning from writing original verse, and, ignominy of ignominies, loss of the laureateship to Shadwell-many have thought that Dryden had to forsake satire of contemporary events altogether. He is supposed to have concentrated instead on the two safe and, he hoped, lucrative avenues left open to him, the theater and translation.' Sir Walter Scott paints a particularly bleak view of Dryden's later life, saying: "His powers of satire, at this period, were of no more use to Dryden, than a sword to a man who cannot draw it; only serving to render the pleasure of insulting him more poignant to his enemies, and the necessity of passive submission more bitter to himself." Scott goes on to enumerate some of "the numerous satires, libels, songs, parodies, and pasquinades" directed either wholly or partially against Dryden and concludes, "it seems certain, that he made no formal attack on the government, either in verse or prose."2 Scholarship over the past three decades has increasingly shown, however, that while Dryden dared make no formal or open attack upon the government of William III, he was not prevented from making frequent clandestine protests in his later plays and translations against a regime he considered repressive and usurpative. As one critic says of Dryden and his literarily expressed dissent after the Glorious Revolution, "In 1689 and for eleven years thereafter he certainly did not lack either courage or consistency in the face of overwhelming opposition."3 The purpose of this article is to establish for Dryden's translations of Juvenal and Persius (1693) a hitherto unnoticed place in the series of furtive political statements Dryden made during the last ten years or so of his life. I wish, furthermore, to suggest that these translations played a key and transitional role in Dryden's changing strategy of concealed comment, which of necessity grew ever more cautious as the 1690s progressed. More than merely eloquent examples of what Dryden thought formal verse satire should be, these translations contain the surreptitious and personal equivalents of Dryden's once bold and public method of political satire exhibited ten years earlier in "Absalom and Achitophel" and "The Medall," political poems written at the height of the Stuart laureate's fortunes. Besides contributing to his translations of ancient authors, therefore, Dryden's Juvenal and Persius should be viewed as part of his extensive list of works involved with political comment and satire. Dryden pursued three different strategies of protest after 1688, each more cautious or indirect than the one before it. Immediately after the Revolution he returned to writing for the theater and there seemed to hope to produce plays with


Aims: To assess the source rock characteristics and the depositional environment through Geochemical studies of sediment samples from the Upper Benue Trough. Place and Duration of Study: Department of Geology, Obafemi Awolowo University, Nigeria and The Activation Laboratory Ltd, Ontario, Canada between February 2011 and March 2012. Methodology: Eighteen samples made up of sand, shale, coaly shale, shaly sand and sandy shale, occurring between the depths of 18.3 m and 2725 m were analysed for thirty-four elements, comprising eight major, twelve trace, and fourteen rare earth elements (REE) using the Inductively Coupled PlasmaMass Spectrometry technique. Results: The results show that the sediments are compositionally rich in Al2O3 and Fe2O3. The low TiO2 values of compared to those of Post-Archean Australian average shale (PAAS) suggest that they were derived from more evolved felsic source rock. The relatively low average Rb/Sr and high Th/U ratios indicate that moderate to more intense weathering occurred in the source rock area. The absolute rare earth elements (REE) concentrations were in the order of coaly shale > shale > sandy shale > shaly sand > sand. Original Research Article British Journal of Applied Science & Technology, 4(20): 2931-2945, 2014 2932 Conclusion: The Al2O3/TiO2, Eu/Eu*, Th/Sc, La/Sc, Th/Co, La/Co, and Th/Cr ratios indicate that the sediments were probably derived from felsic source rocks. In addition, the high LREE/HREE ratios and the negative Eu anomaly also support felsic source rocks for the sediments whilst the very low V/Cr ratios indicate that these sediments were deposited under anoxic environment, consistent with the series of horst and graben structural framework model of the Benue Trough.


1Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, USA, 2Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea, 3Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA, 4 Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA, 5Watson Group, IBM Almaden Research Centre, San Jose, CA, USA, 6Department of Chemistry, University of California Berkeley, Berkeley, CA, USA, 7Department of Bioengineering, Rice University, Houston, TX, USA, 8Department of Physics and Astronomy, Rice University, Houston, TX, USA, 9Laboratory of Molecular Simulation, Institut des Sciences et Ingénierie Chimiques (ISIC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Sion, Switzerland


Intrauterine Growth Restriction (IUGR) is defined as the inability of a fetus to gain the normal growth potential due to maternal-placental-fetal factors. These factors mainly involve metabolic disorders, infections, substance abuse and exposure to harmful substances. Incidence of IUGR is higher in developing countries. Proper diagnosis at suitable time is necessary for proper treatment and management. Although, the mechanism is not clear but oxidative stress, immunological factors, aryl hydrocarbon receptor and adduct formation are some pathways which are involved in IUGR. The aftermaths of IUGR involves post-birth complications, perinatal mortality and morbidity. Therefore, management and treatment involves use of both pharmacological (Tocolytics, Corticosteroids, antibiotics) and non-pharmacological methods (bed rest, cerclage). This review highlights the possible risk factors, mechanisms, other biochemical pathways involved, as well as pharmacological and non-pharmacological management of IUGR. Journal of Biomedical Sciences. 2015;2(4):31-37


Objective To investigate the dynamic changes of serum matrix metalloproteinase-9(MMP-9),interleukin-6(IL-6) in neonates with hypoxic ischemic encephalopathy(HIE) and its correlation with brain injuries.Methods 40 HIE neonates were chosen as HIE group,the concentrations of MMP-9 and IL-6 were measured by ELISA method at day 1,3,and 7 after invasion.Meanwhile 20 healthy newborns were chosen as healthy control group,and concentration of MMP-9 and IL-6 in both groups were compared.Results 1 d,3 d,7 d after invasion,the levels of MMP-9 and IL-6 in HIE group were significantly higher than that in healthy control group,and the difference was significant(P0.05),especially on day 3,but both decreased afterwards.Spesrman rank correlation analysis results showed significant positive correlation between the disease degree and MMP-9,IL-6 levels on day 3.Conclusion Serum MMP-9,IL-6 levels may be valuable in predicting the prognosis and degree of disease.


ABSTRACT The systematic, paleoecology and taphonomy of the Turonian (Azilé Formation) oysters fauna from the geological section PK 12, South of Libreville - Gabon, are carried out. Twelve species from seven genera are described. Genera Curvostrea Vyalov, 1936 ; Gryphaeostrea Conrad, 1865 ; Gyrostrea Mirkamalov, 1963 ; Ilymatogyra Stenzel, 1971 ; Ostrea Linnaeus, 1758 ; Rhynchostreon Bayle, 1878 and all species are recorded herein for the time in Gabonese coastal basin. The assemblage is dominated by representatives of the genus Ostrea and can be regarded as parautochthonous. The oyster shells are thin and thick with medium to large size. The paleoecological study indicates a nearshore shallow marine environment with high energy, nutrient-rich and well oxygenated water column. Taphonomic observations show that shells of oyster are affected by disarticulation. Bioerosion, traces of predators and encrustation are scarcity or absence. Abrasion, breackage and high fragmentation of shell are generally lacking.


Abstract
Research was conducted to evaluate the in-vivo anticoccidial activity of crude leaf powder of Azadirachta indica against Eimeria tenella, the cause of caecal coccidiosis that inflicts heavy economic loss to poultry industry all over the world. A total of 120 broiler chicks were infected via the oropharyngeal route with viable sporulated oocysts of the parasite and allotted to four groups designated 1 to 4 and each group replicated 3 times with 10 birds per replicate in a completely randomized design. Groups 1 and 2 were fed diet containing 100g and 50g leaf powder of the evaluated material per Kg of feed respectively. Group 3 was treated with 0.3g (preventive dose) of AmproliumR per liter of drinking water while group 4 was left without treatment. The test substance given especially at the rate of 100g demonstrated efficacy in decreasing oocysts shedding, minimizing diarrhea, alleviating caecal damage and lowering morbidity caused the parasite but less than the conventional drug. However, its effect in reducing blood loss and mortality was almost similar that of the standard drug (P≤0.05). Although the test material had slight negative effect on feed consumption and weight gain but it can still be used for prophylactic control of coccidioisis especially when there is resistance to conventional anticoccidial drugs or where they are not available or affordable.


Objective To explore the injury mechanism and treatment of uncinate process fracture of the cervical spine. Methods Nine cases (4 males and 5 femals) at ages of 18-31 years (mean 23.5 years) who were admitted into our department from January 1976 to December 1999 were reviewed. There were 5 uni lateral fractures, 2 bilateral fractures and 2 fractures involving uncinate processes of 2 cervical vertebrae. There were 4 cases of C 5 fractures and 7 cases C 6 fractures. Six cases were given operation but three cases non-operation. All the cases were followed up for 3-24 years (average 11 years). Results Operation won good results. However, in the non-operation group, different degrees of neck pain, dizzy and hand numbness were left. Two cases showed obvious degeneration of cervical spine when they were at age of 30 years. Three cases were found with cervical spondylosis when they were 35 years old. Conclusions The fractures were resulted from instantaneous rotation and lateral flexion of the neck. Once an X ray examination shows that an intervertebral space is wide more than 2 mm under an anteroposterior view of right and left flexion of the cervical vertebra, CT scan (the best thickness is 2 mm) should be applied for a specific diagnosis. If such kind of fractures are treated improperly, the cervical spondylosis will occur more earlier than expected.


G e o r g T h i e m e V e r l a g K G , R ü d i g e r s t r a ß e 1 4 , 7 0 4 6 9 S t u t t g a r t , G e r m a n y 1259 Y . C A I , X . Y E , S . L I U , S . L . S H I * ( S H A N G H A I I N S T I T U T E O F O R G A N I C C H E M I S T R Y , P . R . O F C H I N A ) Nickel/NHC-Catalyzed Asymmetric C–H Alkylation of Fluoroarenes with Alkenes: Synthesis of Enantioenriched Fluorotetralins Angew. Chem. Int. Ed. 2019, 58, 13433–13437.


In many places in the world, there are communities of Indigenous Peoples—the first Peoples that inhabited those lands. Each community has its own unique history, culture, practices, spiritual beliefs, and worldviews. I work as a psychologist in Indigenous Peoples' communities in northern Canada, exploring how we can use scientific methods, combined with the traditional wisdom of communities and culture, to improve mental health. In this article, I will tell you about Indigenous Peoples, how many view health and wellness, and what I do to support their mental health—specifically with groups of young people who are having trouble with substance use. I hope that this article will inspire you to find ways to combine scientific approaches with traditional wisdom, to improve your own wellbeing.


DISSECTION of the aorta is the most common acute disease of the aorta. Without therapy, it is highly lethal. In the classic series of Hirst et al, 1 62% of the patients were dead within seven days of the time of the onset of symptoms, and 93% were dead within a year. Few patients die instantaneously; the majority survive long enough for the diagnosis to be made. If the clinician recognizes dissection of the aorta, he now has available highly successful medical or surgical therapy. With appropriate therapy, the mortality of dissection is less than 20%. 2 Recognition of aortic dissection is difficult because it is almost always confused with acute myocardial infarction. Pathophysiology The lesion that predisposes to dissection is cystic medial necrosis. 3 The cause of cystic medial necrosis is unknown. We do know that hypertension and Marfan's syndrome predispose to this lesion in the media of the


Multi-disciplinary performance that explored interactive elements between video, sound and glitter. Generative loops were used to create a dynamic sonic field above a bass speaker, which acted as a performative space for different types of glitter. This was then integrated into video using a multi-camera set-up, and mixed with graphic modifiers. Generative sound feedback was also achieved by recording the audience and glitter bounce.


Scientific Justification The evolution of gas, metals and stars in galaxies are closely coupled. The damped Ly-α quasar absorbers (DLAs; defined as log N(HI) > 20.3 cm) constitute most of the neutral gas in galaxies, enough to form all the stars visible today [1]. They offer a direct probe of metallicities of galaxies over > 90% of the age of the Universe [2]. The damping profile of Lyα easily yields an accurate measure of the H I column density, a first step in measuring abundances, and the relatively high columns enable weak, unsaturated transitions of important ions to be detected. A great deal of ground-based large telescope time has gone into measuring the column densities of different elements and ions using UV absorption lines redshifted into the optical [2-4]. As a practical matter, however, several effects make the interpretation of ultraviolet spectra difficult for DLAs. Saturation of the absorption lines, particularly for the more abundant elements like C, N and O, mean that column densities are difficult to determine. More importantly, elements condense out of the gas phase onto dust grains, so that the absorption line columns are estimated to be low by factors of 3-5 for lightly refractory elements such as C, N and O, and depleted by factors of ∼1000 or so for Fe, Mg or Si. The exact ratio depends on details of the grain chemistry, and the particular history of shocks which the material has suffered. Wide variations in the depletion factors are seen empirically in Milky Way ISM clouds [5,6]. One element which is not significantly depleted onto dust, however, is zinc [5], and studies of the ultraviolet Zn II absorption lines yield the most reliable measurements to date of the true metallicity of the damped Lyα systems [2,7,8]. Zinc shares the same nucleosynthetic origin as iron and so Zn/H gives a reliable indication of Fe/H. Iron unfortunately suffers heavy, variable depletion onto dust grains and therefore is impossible to use to measure abundances [5]. Sulphur is also relatively undepleted, but the strong ultraviolet S II lines are blended with much stronger Si II lines and are difficult to use for abundance measurements [8]. High quality echelle spectra have been used to investigate the detailed abundance pattern in damped Lyα absorbers of heavy elements in addition to zinc. The interpretation of the results is not clear (see [9-11]). The observed pattern is consistent with (1) the solar ratios modified by depletion onto dust grains, or (2) the Galactic halo pattern (Pop. II) with little dust depletion. The problem is disentangling the effect of dust depletion from the intrinsic metallicity variations, in the face of large uncertainties due to saturation of the lines of the most abundant elements and the uncertain ionization corrections. The signature of Population II abundances is an enhancement of oxygen and intermediate-mass even-proton nuclei (Ne, Mg, Si, S, Ar and Ca) relative to the iron group elements (Fe, Zn, Cr) [12,13]. This is observed very clearly in the analysis of the oldest, metal-poor halo stars in the Milky Way where the Oxygen Group (by which we mean O, Ne, Mg, Si, S, Ar and Ca) is enhanced by a factor of 3 relative to solar ratios of iron and even-Z iron peak nuclei (Zn, Fe, Cr, Ni) [13]. The reason is that Oxygen, along with other α-elements, is produced primarily by massive stars which evolve on short time scales compared with the lower-mass progenitors of Type Ia SNe which produce most of the iron group elements such as Zn. It is therefore expected that O/H will increase towards the solar value earlier than Zn/H, particularly given the high star-formation rates expected in the early stages of galaxy evolution. Here we propose to continue our program of searching for X-ray absorption associated with damped Lyα absorbers. The X-ray absorbing column will measure the metallicity of the gas independent of dust depletion and saturation effects, and is caused by exactly those elements (O, Ne, Mg, Si, S, Ar, Ca) which are expected to be enhanced in Pop II objects ([14]; see Figures 1 and


Abstract : An investigation was made of characteristics of certain h.p.h.f. tubes capable of at least 100KW peak output power at up to 32 MHz which contribute to the generation of individual spurious lines in the transmitted spectrum in excess of 90db below the maximum output power. The objective was to identify noise sources within the tubes and recommend design changes to reduce the spurious outputs to the desired levels. The program resulted in a thorough noise generation evaluation of the particular class of tubes, recommended design changes to further reduce the noise generation, and noted significant factors that should enable equipment designers to minimize the noise outputs of existing tubes. (Author)


In this paper a dispositional account of meaning is offered. Words might dispose towards a particular or 'literal' meaning, but whether this meaning is actually conveyed when expressed will depend on a number of factors, such as speaker's intentions, the context of the utterance and the background knowledge of the hearer. It is thus argued that no meaning is guaranteed or necessitated by the words used.


We demonstrate a polarization Michelson interferometer with one mirror replaced by a controllable mirror. The phase of the reflected beam and thereby the polarization state can be selectively modified in two dimensions. The required phase shift of the controllable mirror is induced by heating a thin layer of an aqueous Rhodamine B dye solution. Upon heating, the thermal dispersion of water of −1.5 × 10−4 K−1 leads to a reduction of the refractive index and thereby a reduction of the optical path length. Heating is performed by illuminating the dye layer with the pattern from a video projector.


A new computer vision based strategy for substation distortion state monitoring and diagnosis is proposed, i.e., the current state of substation is classified by comparison between the monitoring images of current substation state and the historical monitoring images of substation to determine whether the images and alarm signals should be transmitted. When alarm signal is received, dispatching center observes the images and processes the abnormal situation. The architecture of the proposed monitoring and diagnosis system are described in detail, the power equipment state diagnosis process based on remote image recognition is discussed. Then combining with the preprocessing of images, the prior information based determination method for readouts of electric instruments is expounded and appropriate optimizing algorithm is put forward. Through the optimization of monitoring strategy and image recognition, the requirement to the communication channel for this computer vision based substation state diagnosis system is reduced, and the dispatchers' burden to continuously observe lots of real-time images is remarkably lightened.


The article is devoted to the characteristics of a short dictionary of IT terms for specialists in language education. The article analyzes the peculiarities of lexicographic definition, and focuses on the difficulties and problems associated with the description of new terminological concepts and definitions that arise in the development of information and communication technologies and their active implementation in language education. The principles of term selection, various ways of semantics and translation are considered. The structure of the dictionary, features of dictionary entries and indexes are described. Examples of dictionary entries are provided.


This study was designed to evaluate the bioequivalence of the newly developed delayed‐release oral suspension (test) 40 mg esomeprazole magnesium compared to its marketed counterpart (40 mg; reference) in healthy adult Chinese subjects. We conducted randomized, open‐label, two‐period, single‐dose, two‐way crossover trials over a 7‐day washout period, comprising a fasting trial and a fed trial. The subjects were administered the test or reference products in a 1:1 ratio at random throughout each period. Then, in the next session, they received the alternate products. Liquid chromatography‐tandem mass spectrometry and WinNonlin software were used to assess the bioequivalence of esomeprazole peak plasma concentration (Cmax) and area under the concentration–time curve (AUC). Overall, 33 subjects participated in the fasting trial and 42 subjects participated in the fed trial. Under both situations, the 90% confidence interval for the ratio of geometric means of Cmax, AUC0‐t, and AUC0‐∞ were within equivalence ranges (80%–125%). In these trials, no severe adverse events or protocol violations were observed. Moreover, when esomeprazole was administered while fed, the tmax was delayed, and both Cmax and AUC were reduced. The results of this research suggest that the test and reference formulations were bioequivalent under fasting and fed states.


In October 1982, the Satellite Television Corporation (STC), a subsidiary of the Communications Satellite Corporation (Comsat), contracted with RCA Astro-Electronics to design, develop, and manufacture the first direct broadcast satellite for use in the United States. The contract is for two spacecraft with an early 1986 launch from either Kourou, Guiana, or Kennedy Space Center, Florida. The program is on schedule with all designs finalized, component qualification virtually complete, and the first spacecraft undergoing integration. Although the system will be implemented in phases, some recent design changes will permit the two collocated satellites to deliver six DBS channels to the entire conterminous United States (CONUS), three channels per satellite. Orbital location will be 110° W longitude, which is one of the eight orbit locations specified for the United States at the Regional Area Radio Conference (RARC) in 1983. Each channel is designed to generate 220 W of RF power in the 12.2-12.7 GHz band at the beginning of life; an allowance is made for TWTA efficiency degradation with life to provide 200 W of RF power at the end of life. The three channels per spacecraft are provided whenever the spacecraft is illuminated by the sun, with no requirement for eclipse operation. Each spacecraft has the capability to transmit in either of two different coverage configurations: it can provide coverage to CONUS or to half-CONUS at an increase in e.i.r.p. of approximately 3 dB. This provides additional margin should STC need the higher e.i.r.p. in the future or provides for a flexible time-zone coverage of the United States.


ln its evolution, the ideolistic philosophy in Song Ming dynasties not only had to endure the attacks from the maferialism, but also experience the affliction from the domestic spliting . The evoluting course experienced from haste establishment to complefe system, then to perishment; from mixture branches to confronting each other, then to the materialistic development of confusion of similarity and difference.


The excited 4[sup +] state at 7117 keV in [sup 18]O is studied via the [sup 12]C([sup 7]Li,[ital p][gamma])[sup 18]O reaction. We show that it is highly improbable that the state is energetically degenerate with a state of different decay properties and that its [gamma] decay is consistent with previously reported values. We obtain a [gamma]-branching fraction [Gamma][sub [gamma]]/([Gamma][sub [gamma]]+[Gamma][sub [alpha]])=0.561[plus minus]0.013 which together with recent results for other decay properties gives a [ital B]([ital E]2) value of 6.4[plus minus]1.6 Wu for the 4p-2h intraband transition 7117 4[sub 2][sup +][r arrow]5260 2[sub 3][sup +]. Shell-model calculations in a full (0+2)[h bar][omega] basis supplement a previous SU[sub 3]-truncated (0+2)[h bar][omega] calculation to the effect that the calculations result in a considerably more collective [ital B]([ital E]2) value of [gt]15 Wu for this transition leaving a rather puzzling discrepancy between experiment and theory.


(1969). 'Who shall inherit England?' A Comparison between Howards End, Parade's End and Unconditional Surrender. English Studies: Vol. 50, No. 1-6, pp. 101-105.


Objective:To investigate the concentrations of vascular endothelial growth facter (VEGF) and epithelial neutrophilactivating peptide-78 (ENA-78) in the serum of patients with endometriosis,and to explore the role of them in the pathogenesis of endo-metriosis.Methods:Serum concentrations of VEGF and ENA-78were measured by enzyme-linked immunosobent assay (ELISA) in 48 patients with endometriosis (22 in stages Ⅰ,Ⅱ and 26 in stages Ⅲ,Ⅳ) in comparison with 40 women without endometriosis.The correlation of serum concentrations of VEGF and ENA-78 and the relationship between the levels of these cytokines and dysmenorrhea were analyzed as well.Results:Concentrations of VEGF and ENA-78 were statistically higher in serum from endometriosis patients than that from controls (P 0.05).Serum concentrations of VEGF and ENA-78 were statistically higher in stages Ⅲ and Ⅳ than that in stages Ⅰ and Ⅱ (P 0.05).The levels of VEGF and ENA-78 were positively correlated in serum of patients with endometriosis (r=0.572,P 0.05).The levels of VEGF and ENA-78 in the serum of patients were uncorrelated with the severity of dysmenorrhea (P 0.05).Conclusion:Increased serum levels of VEGF and ENA-78 indicate that these cytokines may play an important role in the pathogenesis of endometriosis.The levels of VEGF and ENA-78 in the serum have no significant correlation with the dysmenorrhea.


In this article, we study the problem − div(K(x)∇u) = a(x)K(x)|u|q−2u+ b(x)K(x)|u| −2u, x ∈ R , where 2∗ = 2N/(N − 2), N ≥ 3, 1 < q < 2, K(x) = exp(|x|α/4) with α ≥ 2. Under some assumptions on the potentials a(x) and b(x), we obtain a pair of sign-changing solutions of the problem via variational methods and certain estimates.


The first observations conducted as part of the Chandra ACIS survey of M33 (ChASeM33) sampled the eclipsing X-ray binary M33 X-7 over a large part of the 3.45 day orbital period and have resolved eclipse ingress and egress for the first time. The occurrence of the X-ray eclipse allows us to determine an improved ephemeris of mid-eclipse and binary period as HJD (2,453,639.119 ± 0.005) ± N(3.453014 ± 0.000020) and constrain the eclipse half-angle to 26.°5 ± 1.°1. There are indications for a shortening of the orbital period. The X-ray spectrum is best described by a disk blackbody spectrum typical for black hole X-ray binaries in the Galaxy. We find a flat power density spectrum, and no significant regular pulsations were found in the frequency range of 10-4 to 0.15 Hz. HST WFPC2 images resolve the optical counterpart, which can be identified as an O6 III star with the help of extinction and color corrections derived from the X-ray absorption. Based on the optical light curve, the mass of the compact object in the system most likely exceeds 9 M☉. This mass, the shape of the X-ray spectrum, and the short-term X-ray time variability identify M33 X-7 as the first eclipsing black hole high-mass X-ray binary.


Previous analytical models of ac coupling losses in multifilamentary composites under a time-varying external magnetic field were developed for specific strand geometries. Therefore, no global expression of coupling losses was established for any circular geometry. The purpose of this paper is, thus, to present the general analytical strategy and the assumptions of the model developed at CEA. Furthermore, coupling losses are generally characterized by a global time constant nτ.In this paper, effective coefficients (analogous to time constants) are developed to reflect the coupling between the different layers. A global linear equation system linking the amplitudes of the electric field in each layer and their time variation and that of the external magnetic field is deduced, establishing a coupling matrix built with time constant coefficients. In addition to the physical interpretation of the quantities defined, the global equation is numerically solved. Local fields are quantified, as well as currents and ac coupling losses in different types of composites. A better physical understanding of the composite is tentatively achieved by the use of this analytical model.


Metabolic syndrome (MetS) is a medical syndrome that entails of visceral abdominal obesity, dyslipidemia, blood pressure, and reduced insulin susceptibility. Though distinct mechanisms of MetS have been associated in the growth of chronic kidney disease (CKD), limited revisions have studied the result of mixtures of the mechanisms of MetS on the progress of CKD and cardiovascular disease (CVD).


Magnetic properties of the intermetallic compound NdCo$_2$Si$_2$ are investigated by using the Monte Carlo simulation (MCs) under Metropolis algorithm. The magnetism of the compound is caused by the existence of the rare earth (Nd3+) ions with a magnetic moment taking the value 2.7 muB. Firstly, the ground state phase diagrams are presented and discussed in different planes corresponding to different physical parameters of the system. The stable phases are explored for different configurations of the Hamiltonian of the system. These stable phases are determined by the minimal energies. For non-null temperature values, we compute the magnetizations and susceptibilities behaviors as a function of temperature by using the Monte Carlo simulations (MCS). Also, we present the magnetization behaviors as a function of the exchange coupling interactions, the crystal field and the external magnetic field. Finally, we present and discuss the magnetic hysteresis loops of the intermetallic NdCo2Si2 compound as a function of the external magnetic field for fixed values of temperature and the other physical parameters.


This paper briefly introduces the etiology and pathogenesis of vertigo in the ancient times and presents different characteristics of ancient doctors.


Making use of sound wave measuring well data in triaxiality earthquake explore explain in Banji well,increase explain accuracy and get the verification in practice.


Bispecific T-cell Engagers (BiTEs) are a promising immunotherapeutic approach, usually consisting of two single chain variable fragments (scFv) linked in tandem. One arm binds to tumour-associated antigens, whilst the other binds CD3 on T-cells, facilitating the formation of cytotoxic synapses leading to killing of tumour targets in a MHC and co-stimulatory molecule independent manner. Blinatumomab, the most advanced BiTE in clinic targets CD19 and has shown impressive results in patients with relapsed/refractory B cell acute lymphoid leukaemia but results in elimination of normal and malignant B lymphocytes. Receptor Tyrosine Kinase Like Orphan receptor is a surface antigen expressed on a range of haematological and solid malignancies, including Chronic Lymphocytic Leukaemia (CLL), Acute Lymphoblastic Leukaemia (ALL), and cancer stem cell-like cells (CSC). It is however expressed at low or undetectable levels in normal tissues making it an attractive target for immunotherapy approaches. We generated a panel of novel fully humanised ROR1 antibodies and selected an optimal scFv based on ROR1 binding to use in our BiTE format. Our ROR1 BiTE (ROR1xCD3), at low concentrations, was efficient inducing T-cell mediated cytotoxicity and consequent inflammatory cytokine secretion against a panel of haematopoietic cell lines with constitutive ROR1 expression in vitro. Importantly cytotoxicity was comparable to that seen with a control CD19 BITE. Moreover, ROR1xCD3 led to significant and selective cytotoxicity of primary CLL samples. We transitioned our in vitro studies to animal models and showed that our ROR1xCD3 is able to retard growth of established SKW cells engrafted in immunocompromised mice, as detected by bioluminescence imaging. Additionally ROR1xCD3 improved survival, with the ROR1xCD3 treated cohort showing improved median survival of 50 days compared to control mice of 18 days despite only receiving a single infusion of T-cells. In summary, we have developed a novel ROR1 BiTE able to target an array of haematopoietic malignancies. Our ROR1 BiTE induces T-cell cytotoxicity against ROR1 positive cell lines in vitro and in vivo as well as primary CLL cells and has the potential to be a beneficial therapeutic for CLL. Disclosures Gohil:UCL Business: Patents & Royalties: ROR1 based immunotherapies. Paredes-Moscosso:UCL Business: Patents & Royalties: ROR1 based immunotherapies. Nathwani:UCL Business: Patents & Royalties: ROR1 based Immunotherapies. Della Peruta:UCL Business: Patents & Royalties: ROR1 based immunotherapies.


The interlining is a type of strong fabric, closely-woven, scarcely fi ne. As its name suggests, it has as a key role to be between other pieces of fabric, providing them with structure, attachment, security and elegance.


We present two moment matching-based solutions to the problem of rational approximations of a finite-impulse response (FIR) system: a direct moment matching approximation performed on the FIR system and a sequential moment matching approximation performed on a block split model of a FIR system. Imposing moment matching conditions yields families of parametrized, low-order, rational approximations of the FIR filters, with guaranteed low frequency behavior. We show that the block rational implementation from [1], [2] is a particular case of the sequential moment matching result. The theory is illustrated with an example of a FIR system, where we select the free parameters such that the approximations are stable and more accurate. We compare the proposed approximations with existing rational implementations of the FIR system as well as with Loewner matrices-based approximations.


The present study was carried out to determine the time-dependent changes in the cortical granule (CG) distribution and the glycoprotein compositions of zona pellucida (ZP) after egg activation by electrostimulation in porcine oocytes matured in vitro. CG exocytosis was observed by staining with fluorescein isothiocyanate-labeled peanut agglutinin (FITC-PNA) and laser confocal microscopy, and ZP modification was analyzed by using enhanced chemiluminescent (ECL) detection of the biotinylated ZP derived from a single oocyte. In the oocytes matured in vitro, CGs staining with FITC-PNA had formed a continuous monolayer underlying the oolemma, and three major bands (ZP1, ZP2 and ZP3) were observed in a biotinylated ZP subjected to SDS-PAGE followed by ECL detection. Electrostimulation to induce artificial activation caused a decline in the fluorescent intensity of the CGs with a concomitant decrease in the amounts of ZP1 and ZP2 bands, but CG exocytosis according to oocyte activation occurred slowly, and the incidence of oocytes with complete CG exocytosis was first observed 1.0 h after electrostimulation (9%). Similarly, the complete ZP modification, i.e. a maximum decrease in amounts of ZP1 and ZP2 bands, required more than 3.5 h after artificial activation, and the ZP dissolution time caused by 0.1% protease action increased apparently as incubation time was prolonged after electrostimulation. Results of these experiments suggest that the slower ZP modification due to the delayed CG exocytosis in porcine oocytes may reflect the remarkable increase in polyspermy frequency in in-vitro fertilization.


In this study, the fire resistance of steel composite beams typically used in building structures was investigated through standard fire and loading tests. For the tests, fire-exposure conditions depending on the steel section shape and load ratio applied to the beams were considered as the test parameters. Based on the test results, the applicability of fire design methods for composite beams recommended in current domestic and overseas fire design codes was analyzed. The results indicate that the current temperature-based design method and reduced flexural capacity method specified by the American Institute of Steel Construction may lead to the conservative fire design of steel composite beams owing to the underestimation of the effects of the fire-exposure conditions and load ratios.


Abstract Low-temperature drift, diffusion and energy relaxation of non-equilibrium carriers in a one-dimensional hopping system with built-in intrinsic energy disorder are treated analytically employing a master equation approach. The analytical results for energy relaxation are compared with computer simulation and very good agreement is found.


Although lung resection still provides the best long-term outcome for lung cancer, it is also associated with a considerable decay in physical and psychosocial health status. If not controlled, these symptoms can hamper postsurgical recovery, and lead to unscheduled healthcare use. This study aimed to determine the clinical relevance of and functional requirements for a telerehabilitation (TR) service to support recovery following lung resection.
A modular remote monitoring and treatment service, consisting of an ambulant health monitoring module and an online exercise program, was developed to improve survivorship care following lung surgery through a user-centred design approach. Results from the requirement elicitation indicate positive intentions of both patients and professionals to use the RMT service as part of current care practice. In early phase evaluation usability and technical reliability of the developed system was found high. Future research should establish level of adoption of the system by the end users, as well as the effects on post-surgery recovery when integrated with current healthcare processes.


Through a partnership with the National Science Foundation-funded Migration in Harmony Research Coordination Network and the Ecologic Institute, The Arctic Institute is publishing a series of briefs on Arctic migrations and mobilities written by Fellows of the 2021 Arctic Winter College. The Arctic Winter College brought together 60 emerging leaders and experts from across the world for 10 weeks in a free series of web-based seminars, the videos of which can be viewed on YouTube here. The program builds a lasting, policy-oriented network of Arctic professionals to strengthen communication between peoples and nations, scientific disciplines, policy areas, and across the science-policy interface to improve collaborations, research, and decision-making in the Arctic. Weekly webinars focused on the theme "Arctic on the Move." Urbanization, globalization, and the impacts of climate change are activating the simultaneous migrations of species, ecosystems, settlements, and cultures across Arctic coastlines in new and unpredictable ways. Each of these intersecting mobilities challenge the quality of life, sustainable development, and environmental health of the circumpolar north. to to deepen their understanding of a rapidly changing region and its global Massachusetts Institute of Technology the History of Architecture where focuses on transportation and infrastructure systems in the twentieth century. EXECUTIVE SUMMARY This briefer addresses the lack of discussion of land transportation infrastructure, namely roads, bridges, and railways, in U.S. national security and research documents that focus on the Arctic region from the last five years. In considering strategy documents from the Congressional Research Service, the Interagency Research Policy Committee, the Department of Defense, and the Department of the Air Force, I analyze how they discuss infrastructure and terrestrial Arctic space. I find the commentary on land transportation infrastructure lacking, in comparison to maritime infrastructure, and recommend that it should be researched and invested into the same extent as other kinds of infrastructures. Land transportation infrastructure is crucial to human, military, and economic security of the region, and could be instrumental in fulfilling the documents objectives, namely cooperation among allies and partners. EXECUTIVE SUMMARY This brief draws on an ongoing remote ethnographic study i examining how varying modes of housing insecurity are experienced by Alaskans. This includes: puts forward a problem of whether it's worth developing a holistic approach, or it would be more rational to alternate the approaches and to perceive them as stages of smart urban development.


Phase separation driven by a reversible photo-cross-linking reaction was investigated by using anthracene-labeled polystyrene/poly(vinyl methyl ether) (PSA/PVME) blends. Upon irradiation with 365 nm ultraviolet light, anthracene moieties undergo photodimerization, leading to phase separation of the two polymers. On the other hand, the homogenization process of the phase-separated blend was induced by irradiation with 297 nm which converted photodimer back to anthracene monomer, thus de-cross-linking the PSA networks in the mixture. The kinetics of phase separation and the corresponding homogenization processes driven by these two UV wavelengths were followed in situ under a light scattering instrument equipped with a UV light source. Unlike the conventional kinetics of phase separation in nonreacting mixtures, it was found that the scattering peak shifts toward the side of larger wavenumber as phase separation proceeds under 365 nm light. The local elastic deformation of the blend monitored along the cour...


In the presentation-type lectures which is performed using presentation software, learners are provided well-structured slides which are useful to understand the structure of the lecture. They, however, don't need to construct their note because of the given slides. In this paper, we propose a task called "note-rebuilding" which is based on a kit-build method. We also report a learning support system with note-rebuilding and its experimental evaluation.


The family is the small society but has a very large role in a nation. In the family has a woman (wife) is very many the role of the family in the make of a family, comfortable, peaceful and harmonis or can we call the happy family. This priority of the attitude and the nature of the woman (wife), because of the woman is what will be the nation's character will be grow. Existence, responsibility (liability), as well as their rights also must be known to determine how the role of women in the establishment of harmonis family. This resesarch is useful for writers to add insight  the mindset, attitudes, and experiences in an effort to improve the quality of learning, by understanding the nature of wife role in the establishment of harmonious family. The etica of wife in the establishment of harmonious family perspective according to the Qur'an perspective Tafsir Al- Misba>h and Tafsir Al-Azhar explained that a role to make  by wife in terms of family formation sakinah, such as  those reviewed in the perspective of Tafsir Al- Misba>h and Tafsir Al-Azhar . From these results, the authors concluded that the perspective of perspective Tafsir Al- Misba>h and Tafsir Al-Azhar about the etica of wife in happy family according to the Qur'an are the characters in a woman who reflects the character that excels in a family in accordance with the teachings of the Quran. Superior female characters, which have the life processing, habituation, exemplary, find out the obligations and rights within the family. A wife should know the importance of the role of the family, and  there is phrase  al- mar'ah , al-'Imad al-bilad {female pillar of the state), the essence is not missed when it is said that al-usrah 'imad al- bilad biha tah}ya wa biha} tamu>t (family is the pillar of the state, with the families that state to rise or fall). Key words : Role of Wife, Family Sakinah, Perspectives Tafsir Al-Misba>h and Tafsir Al-Azhar.


Microtubule-disrupting drugs have been shown to increase adenylate cyclase activity in synaptic membranes prepared from rat cerebral cortex. Activation of the enzyme by hydrolysis-resistant guanosine triphosphate (GTP) analogues and N a F is augmented by colchicine or vinblastine (ECSo = 5 x IO-'M), whereas basal and Mn++-stimulated (reflecting catalytic-moiety activation) activities are unchanged.' These findings suggest that the microtubule-disrupting drugs increase the "coupling" between the GTP-binding protein that stimulates adenylate cyclase (Ns) and the catalytic moiety of that enzyme. When these membranes are treated with colchicine or vinblastine and subsequently washed, activity of the Ns protein is released from the membranes into the supernatants. This release of Ns activity is indicative of facilitated Ns-catalytic moiety coupling and is similar to that observed in the homologous cGMP phosphodiesterase cascade from retinal rod outer segments.* Incubation of tubulin (ECS, = 0.5 pg/ml; 10 n M ) with synaptic membranes inhibits guanyl nucleotide and NaF activated adenylate cyclase by 5&60% without altering basal and Mn++ activation of the enzyme (FIGURE 1). The effects of this tubulin incubation are sustained even after membranes are washed. Furthermore, treatments that diminish the amounts of membrane-associated tubulin increase Ns-mediated adenylate cyclase activation. The photoaffinity GTP analogue (P'azidoanilido)-P'-5' G T P (AAGTP) labels both the 42 kD Ns and the 40 kD inhibitory GTP-binding protein (Ni) on the synaptic membranes.' Under conditions where microtubule disrupting drug treatment and subsequent washing releases Ns activity into the supernatant, AAGTP-labeled 42 kD protein is also released from those membranes (FIGURE 2). This labeled 42 kD protein is retained by an agarose-tubulin affinity column, and when eluted from the column, the protein displays Ns activity (reconstitution of Ns-deficient adenylate cyclase). GTP-dependent (Ni mediated) inhibition of adenylate cyclase is unaltered by colchicine or vinblastine treatment, and the 40 kD AAGTP labeled protein is not released from the synaptic membrane by these agents. Although microtubule disrupting drugs increase cyclic adenosine monophosphate (CAMP) accumulation in intact cells: colchicine or vinblastine enhancement of adenylate cyclase in broken cell preparations and the release of AAGTP-labeled Ns has been observed only in membranes from tissues of neural origin. These data lead to the proposal of a hypothetical Ns-tubulin interaction similar to that suggested for actin and f ibr~nect in .~ The physiological significance of a putative Ns-tubulin interaction (association/dissociation) might be to regulate intracellularly the amount of CAMP produced in response to a given neurotransmitter.


Through the analysis of articles with proposals for experimental activities and with current pedagogical, epistemological and environmental discussion on experimentation by Chemistry professors, this paper investigates ways of highlighting relevant methodological characteristics that can be incorporated in experiments. Based on analysis of the suggestions for experiments it appears that of particular importance are: a concern for students' physical welfare and for the effects of residues; the need to confront an impoverished infrastructure that hinders experimentation; and the valorisation of clarifying student knowledge. It argues in favour of the need to set out the problems of experimentation in educators' professional development.


Portfolio management is the art and science of modifying the asset allocation of a financial portfolio in response to and/or in anticipation of market conditions and dynamics of financial markets. The modification of the asset allocation is obtained by rebalancing and varying the relative weights of the assets comprising the portfolio on a periodic basis. The asset manager considers two distinct portfolios: the financial portfolio subject to his management technique (referred to here as the experimental portfolio, or Portfolio "A"), and a benchmark (or comparison) portfolio called Portfolio "B". The asset manager composes his experimental portfolio, also referred to as the benchmark-based portfolio, following, generally, two different types of strategies: active and passive (indexed) strategy. In this work, we analyze a fundamental aspect of portfolio management: the active asset allocation. The objective of this writing is to illustrate a new asset allocation technique to compose an experimental portfolio, which uses the Proportional, Integral, Derivative (PID) controller aiming to overcome a benchmarked portfolio. Therefore, the two portfolios taken into consideration are the experimental portfolio subject to the PID controlling methodology and a buy-and-hold diversified portfolio as the benchmark portfolio. The technique consists in managing portfolio asset-allocation revisions through PID control, a tool that is highly utilized and implemented in the engineering, industrial processing units and in production plants. The goal is to achieve a good portfolio performance trying to control volatility; in other words, the goal is to obtain good performance of risk adjusted returns. Thus, in finance, financial market assets forming a portfolio or a market benchmark represent the process plant controlled by the PID controller. A brief literature review covering the comparison between strategic and tactical asset allocation introduces the topic, followed by some examples of tactical asset allocation techniques. Subsequently, this article illustrates how the PID controller functions. Then, it exemplifies the new asset allocation technique, functioning, and methodology. This work shows how a portfolio managed by this new technique attains fine results of risk adjusted returns compared with a benchmark.


Conceptual review of discourse notions and comparison between historical and literary discourse identifying the elements that make them different but also those making them similar.


Introduction: In India, Tuberculosis is endemic disease with more than 90% of population are  in latent infection. In this study we measure the prevalence of iron deficiency anaemia in newly diagnosed TB cases. Methodology: An Observational cross-sectional study was conducted at Respiratory Medicine, MIMS, Nellimarla, Vizianagaram District, and Andhra Pradesh State from July 2020 to June 2021. Inclusion criteria were newly diagnosed TB patients of age >18 years. Exclusion criteria were Immunocompromised, Pregnancy, Patients with malignancy, Patients with past history of TB and who are receiving ATT Unwilling to participate. Results: During the one year study period, a total of 50 patients were included. 32 were male and 18 were female. The study showed decrease in Iron, Hemoglobin, Transferrin and Transferrin saturation and increase in TIBC and Ferritin levels. They are many available methods for assessing anaemia at primary care level and to treat or iron prophylactic supplementation. Conclusion: In the present study, it was concluded that iron metabolism was altered in pulmonary tuberculosis. A low serum iron, transferrin and transferrin saturation with increase in ferritin and TIBC.


Aerodynamic loads on aircraft wings are one of the key parameters to be monitored for reliable and effective aircraft operations and management. Flight data of the aerodynamic loads would be used onboard to control the aircraft and accumulated data would be used for the condition-based maintenance and the feedback for the fatigue and critical load modeling. The effective sensing techniques such as fiber optic distributed sensing have been developed and demonstrated promising capability of monitoring structural responses, i.e., strains on the surface of the aircraft wings. By using the developed techniques, load identification methods for structural health monitoring are expected to be established. The typical inverse analysis for load identification using strains calculates the loads in a discrete form of concentrated forces, however, the distributed form of the loads is essential for the accurate and reliable estimation of the critical stress at structural parts. In this study, we demonstrate an inverse analysis to identify the distributed loads from measured strain information. The introduced inverse analysis technique calculates aerodynamic loads not in a discrete but in a distributed manner based on a finite element model. In order to verify the technique through numerical simulations, we apply static aerodynamic loads on a flat panel model, and conduct the inverse identification of the load distributions. We take two approaches to build the inverse system between loads and strains. The first one uses structural models and the second one uses neural networks. We compare the performance of the two approaches, and discuss the effect of the amount of the strain sensing information.


Rechargeable aprotic lithium-oxygen (Li-O2) batteries have attracted significant interest in recent years owing to their ultrahigh theoretical capacity, low cost, and environmental friendliness. However, the further development of Li-O2 batteries is hindered by some ineluctable issues, such as severe parasitic reactions, low energy efficiency, poor rate capability, short cycling life and potential safety hazards, which mainly stem from the high charging overpotential in the positive electrode side. Thus, it is of great significance to develop high-performance catalysts for the positive electrode in order to address these issues and to boost the commercialization of Li-O2 batteries. In this review, three main categories of catalyst for the positive electrode of Li-O2 batteries, including carbon materials, noble metals and their oxides, and transition metals and their oxides, are systematically summarized and discussed. We not only focus on the electrochemical performance of batteries, but also pay more attention to understanding the catalytic mechanism of these catalysts for the positive electrode. In closing, opportunities for the design of better catalysts for the positive electrode of high-performance Li-O2 batteries are discussed.


In this study, it was aimed to adapt the Comprehensive Inventory of Mindfulness Experiences-Adolescents into Turkish, and to analyze the measure's validity and reliability. The sample of the study consisted of 415 high school students. Confirmatory factor analysis confirmed the original eight-factor structure. Cronbach alpha coefficient for the overall scale is 0.70 and the coefficients differ from 0.48 to 0.69 for the sub-scales. Corrected item-total correlations are found to be between 0.20 and 0.55. The convergent and divergent validity was examined and statistically significant relations were found. The study showed that the Turkish adaptation of The Comprehensive Inventory of Mindfulness Experiences-Adolescents is a reliable and valid scale for measuring mindfulness in adolescents.


This article reviewing literature to focus the problem- "Increase preterm child birth" analysis through problem tree, which is the participatory tool of mapping out main problems, along with their causes and effects. Child born preterm has a greater effect on their life than infants born at term in respect of mortality and a variety of health and developmental problems. However, those children born nearer to term represent the greatest number of infants born preterm and also experience more complications than infants born at term. The enormous effects of preterm birth include acute unstable health, central nervous system, hearing, and vision problems, as well as longer -term motor, cognitive, visual, hearing, behavioral, social-emotional, health, and growth problems. The birth of a preterm infant can also bring considerable emotional and economic costs to families and have implications for socioeconomic sector. The impact of preterm child birth is the raising number of mort ality and economic burden to the family as well as to the society. Preterm birth is a complex cluster of problems with a set of overlapping factors of influence. Its causes may include maternal health related problems, individual-level behavioral and psychosocial factors, environmental exposures, medical conditions. Many of these factors occurring combination, particularly in those who are socioeconomically and educationally disadvantaged


As is well known, in quantum mechanics, the calculation rule of the probability that an eigen-value a_n is observed when the physical quantity A is measured for a state described by the state vector |> is P(a_n)= . However, in Ref.[1], based on strict logical reasoning and mathematical calculation, it has been pointed out, replacing , one should use a new rule to calculate P(a_n) for particle satisfying the Dirac equation.
In this paper, we first state some results given by Ref.[1]. And then, we present a proof for the new calculation rule of probability according to Dirac sea of negative energy particles, hole theory and the principle "the vacuum is not observable". Finally, we discuss simply the case of particle satisfying the Klein-Gordon equation.


The current status of the use of luminescent nanoparticles for thermometry in animal models is reviewed in detail. The different types of luminescent nanoparticles capable of deep tissue temperature sensing are described, paying special attention to the physical mechanisms at the root of their thermal sensing capacity. Their thermal sensitivities are listed and compared. This review describes the most relevant experiments, in which luminescence nanothermometry has been successfully applied at the small animal level, including the development of controlled thermal therapies as well as subtissue diagnosis procedures. Advantages and disadvantages of different luminescent nanothermometers are discussed.


Launching a new journal is an intimidating prospect, especially in an increasingly-crowded journal marketplace. To be successful (more on "success" later), a new journal must establish an identity; it must stand out from the crowd in some meaningful, positive way. In this editorial, we discuss the manner in which the Journal of the Southern Association for Information Systems (JSAIS) seeks to stand out and contribute to the field of information systems.


This paper describes the techniques used to measure the intensities of the proton (p) and antiproton (p) beams in the Tevatron collider. The systems provide simultaneous measurements of the intensity of the 36 proton and 36 antiproton bunches and their longitudinal profiles.


It is now accepted that the classification of finite simple groups (CFSG) is complete. Our purpose is in constructions which we re-examine in the light of observations that suggest that a substantial amount of insight is to be gained if we pursue novel connections to other, apparently disparate, areas of mathematics. This may lead to a natural home for the 26 sporadic simple groups which today are considered the complement of the Lie-Chevalley groups.


PURPOSE: A method for fabricating a complementary metal oxide semiconductor(CMOS) image sensor is provided to reduce contamination caused by particles generated in a subsequent process by performing a planarization process using acrylic resin with a small index of refraction after a micro lens is formed. CONSTITUTION: The micro lens(7) is formed on a substrate(0) in which relative devices are formed. A planarization layer is formed on the micro lens by using acrylic resin. A low temperature oxide layer(10) is deposited on the planarization layer. An anti-reflective layer is formed on the low temperature oxide layer. The index of refraction of the acrylic resin is smaller than that of the micro lens.


The zirconocene-coupling of diynes with internal silicon substituents, MeC⋮CMe2SiArSiMe2C⋮CMe (1:  Ar = 1,4-C6H4; 2:  Ar = 1,3-C6H4; 3:  Ar = 4,4'-C6H4C6H4), generates regiospecific polymers containing zirconacyclopentadiene in the main chain (5−7). These organometallic polymers hydrolyze cleanly to butadienediyl polymers of the type [Me2SiArSiMe2CHCMeCMeCH]n (11−13), and polymer 5 reacts with iodine to give the iodine-containing polymer [1,4-Me2SiC6H4SiMe2C(I)CMeCMeC(I)]n (14). The organometallic polymers undergo facile and high-yield degradations to macrocycles under mild conditions (refluxing tetrahydrofuran solution). The size and shape of the resulting macrocycles depend upon the nature of the diyne spacer group. Thus, polymers 5 and 7 containing parallel diyne units convert to the trimeric macrocycles [Me2SiArSiMe2C4Me2ZrCp2]3 (15:  Ar = 1,4-C6H4; 24:  Ar = 4,4'-C6H4C6H4), while polymer 6 gives the dimeric macrocycle [1,3-Me2SiC6H4SiMe2C4Me2ZrCp2]2 (18). The dimeric macrocycle [Me2SiC6H4SiMe2C6H4SiM...


Abstract. The aerosol scattering coefficient is an essential parameter for estimating aerosol direct radiative forcing and can be measured by
nephelometers. Nephelometers are problematic due to small errors of nonideal Lambetian light source and angle truncation. Hence, the observed raw
scattering coefficient data need to be corrected. In this study, based on
the random forest machine learning model and taking Aurora 3000 as an
example, we have proposed a new method to correct the scattering coefficient
measurements of a three-wavelength nephelometer under different relative
humidity conditions. The result shows that the empirical corrected values
match Mie-calculation values very well at all three wavelengths and
under all of the measured relative humidity conditions, with more than 85 %
of the corrected values having less than 2 % error. The correction method
obtains a scattering coefficient with high accuracy and there is no
need for additional observation data.


The second perturbation solution is derived within the nonlinear one-dimensional Cosserat theory for a liquid jet emanating from a nozzle with harmonic excitation. Numerical results are presented for parameters relevant to ink-jet printing technology. Satellite drops are predicted but always in the backward merging condition. The results are compared with the corresponding solution obtained by Pimbley and Lee, who used a different one-dimensional set of equations with a different formulation of the problem and obtained forward merging satellite drops under some conditions.


This article analyzes the mistakes of diagnosis and treatment and medical risks in gynecological clinical practice for students of traditional Chinese medicine (TCM) and provides the corresponding strategy in order to decrease the medical risks in teaching of gynecological clinical practice,make the teaching of gynecological clinical practice safe and effective and train the excellent gynecologist of TCM.


It is intellectual capital that attract universities to cooperate with Hi-tech industry for technological innovation.Rich science and technology education resources in Shaanxi give the development of high-tech industry strong support.The rapid development of high-tech industries stimulate business to unprecedentedly demand for knowledge capital.There are four modes of cooperating between universities and Hi-tech industry in technological innovation.It holds that the effective approach for cooperating between universities and Hi-tech industry is continue to play the advantages of Hi-tech industry of the universitie,improve the capacity of converting scientific researches into positive results based on Market-orientation.Local colleges should play an active role in the technology application research.In addition,the intermediary organizations should be set up in order to build the conducive social environment for cooperation between universities and Hi-tech industry.


Objective To study the clinical effects on patients with periodontal diseases after telescopic denture treatment.Methods 24 telescopic dentures in 20 patients who totally had 146 abutment teeth,including 81 of mobility were studied.The follow-up period varied from 3 to12 months.The changes of periodontal pocket depth and gingival index and tooth mobility of patients with periodontal disease,the height of alveolar bone,periodontal width,the loss of lamina dura,questions by questionnaire were determined before and after prosthesis with telescopic denture.Results The observation time was 12 months.The results showed that the average depth of periodontal pocket and the tooth mobility decreased as time passed,and the gingival indexes were better.X-ray showed the lamina dura and periodontal ligament were clear,the height of alveolar bone remained stable,and the bone density increased.The kinds of foods they selected become more with telescopic dentures.Most of those patients were satisfied with their telescopic dentures.Conclusion The telescopic denture is a good method for the treatment of serious periodontal diseases with denture defect.


This study deals with Janet Quin-Harkin's novel entitles "California Girl". It was aimed to see the main character's motivation in achieving her dream. It's a qualitative study which employed psychological approaches. The primary data were in the forms of written expressions found in the narrations, dialogues, sentences and paragraphs in the novel showing the character's behaviour and motivation in pursuing her dream. Data analysis applied procedures, namely data collection, data reduction, data serving, and drawing conclusion. To validate, data sources triangulation was used. The researcher read some related theories through books and articles. The study concluded that: First, Janet portrayed Jennie as a girl who was tall and skinny for her age with short mid-brown hair. She didn't have a good physical outlook. She was introvert; and, therefore she had problem with social relationship. She was emotionally unstable and worried about losing her chance to make the Olympic team. Second, Jennie achieved her dream by trying to fulfil her fundamental needs for priorities. She ate enough food for her physical calories. After that, she fulfilled her psychological needs. She found love in Mark and never let him down. She also wanted to be accepted by her mother. Besides, swimming was her chosen sport to show that she was worth appreciating.
Keywords: Analysis, motivation, dream


We investigated the chemical reactivities of (La0.7Sr0.2Ba0.1)ScO3−δ (LSBS) and LaScO3 powders and Pt foil as functions of reaction temperature, T, oxygen partial pressure, P(O2), and reaction time...


stract-Co-Fe-B-F amorphous and nano-crystalline films were prepared using a high deposition rate sputtering apparatus with two opposing targets. The chemical composition of these films could be easily varied from boron-rich/fluorine-poor to boron-poor/fluorine-rich by changing the quantity of fluorine gas. The content of the metalloid (B+F) was found to be constant in amorphous phases. Soft magnetic properties were obtained for films with high B and low F contents. These films had both a high saturated magnetization of 1.6 to 1.8 T, and a high resistivity, from 150 to 1000 ¿¿-cm. TEM observations clarified that fluorine decreases the size of mici ocrystals from 10 nm to 5 nm in CoFeBF films with low B contents. The simultaneous occurrence of high Bs and high ¿ is attributed to various factors, including the constant metalloid content of (B+F) and a fine texture of mixed phases owing to the presence of F.


Neurodevelopment requires the precise integration of a wide variety of neuronal and glial cell types. During early embryonic development, motor neurons and then oligodendrocyte precursor cells (OPCs) are specified from neural progenitors residing in the periventricular pMN progenitor domain of the spinal cord. Following gliogenesis, OPCs can differentiate as oligodendrocytes (OLs) – the myelinating glial cells of the central nervous system - or remain as OPCs. To generate unique cell types capable of highly divergent functions, these specification and differentiation events require specialized gene expression programs. RNA binding proteins (RBPs) regulate mRNA localization and translation in the developing nervous system and are linked to many neurodevelopmental disorders. One example is Fragile X syndrome (FXS), caused by the loss of the RBP fragile X mental retardation protein (FMRP). Importantly, infants with FXS have reduced white matter and we previously showed that zebrafish Fmrp is autonomously required in OLs to promote myelin sheath growth. We now find that Fmrp regulates cell specification in pMN progenitor cells and subsequently promotes differentiation of OPCs, such that fmr1 mutant zebrafish embryos generate excess OPCs and fewer differentiating OLs in the developing spinal cord. Although the early patterning of spinal progenitor domains appears largely normal in fmr1 mutants during early embryogenesis, Shh signaling is greatly diminished. Taken together, these results suggest cell stage-specific requirements for Fmrp in the specification and differentiation of oligodendrocyte lineage cells.


Chiral arginine was introduced by layer-by-layer assembly onto a calix[4]arene-diacid modified silica surface to control the adsorption of different kinds of ibuprofen droplets. The droplet of (S)-ibuprofen slid off rapidly, whereas the droplet of (R)-ibuprofen absorbed on the modified surface.


cation of incapacity, and finally to express some views on what might be called the therapy of the situation. It might properly be supposed that the core and essence of the doctor's calling is that his whole effort should be directed towards the welfare of his patient. Throughout his training his teachers try, by precept and example, to instil into him this fine tradition of personal service, and in their practices the great majority of doctors honestly endeavour to live


In this article, a compact wide‐band transmission line (TL) with coplanar waveguide (CPW) using left‐handed metamaterial is presented. The proposed CPW TL has an interdigital capacitor and meander line inductor and shows compact size, low loss, and broad bandwidth. The proposed wide bandwidth CPW TL has a bandwidth of 180% from 12.03 to 30.0 GHz and a size of 1.46 × 3.43 mm2. Also, it shows insertion and return losses of 0.13 and 15.1 dB, respectively.


This project aims to develop a team capable of making a measurement of blood glucose levels noninvasively, using an oximetry sensor, which sends visible light with wavelength of 660 nm and infrared light with length wavelength of 890 nm, an electronic circuit that allows to acquire a photoplethysmographic signal which glucose levels are measured and then be displayed on a LCD and sent wirelessly to a smartphone Samsung S3.


Second floor of Nanjing international exhibition center is a large area concrete structure,the scientific and technology are taken to control the crack of the large area concrete structure.


Abstract Ti-ansition facilitating behavior is identified as a concept that bridges Attachment Theory and British Object Relations Theory. It is described i n the context of normal development and examined closely in an infant observation from the neenatal intensive care unit where the compromise of primary splitting presenb particular problems.


Between May 9 and 15 of this year, collections of a rather rare and remarkable fungus were made at Val de Bois, P. Q., in the valley of the Lievre River by Mrs. R. A. Inglis and Mrs. H. T. Giissow. The plants which were collected-I5 to 20 in numberwere gregarious in habit, occurring within the space of a few square feet, and nowhere else could others be found. They were growing beneath some coniferous trees in a bed of needles and humus, and from a distance they appeared like small stumps of young black birches-perfectly flat tops from one to two inches above the ground. At this time they were immature. When the plants were received at this laoratory, several were placed in a moist chamber and allowed to come to maturity. In size, the apothecia varied from 6-Io cm. in width by 4-8 cm. in height. They were globose, sessile, dull-brownish-black in color, spongy in texture and furrowed both vertically and horizontally. Attached to the base were a few fine, branched, rhizomorph-like strands. The exterior of the apothecia was covered by a dense, felty layer of dark-brown hyphae, up to 400 t in length and io / in diameter, multiseptate and somewhat constricted at the septa. These hyphae arose from the outer side of a single row of very dark brown, rounded, pseudoparenchymatous cells. Arising from the inner side of this same row of cells, and forming a tangled network in the colorless jelly-like mass which occupied the whole interior of the apothecia, were innumerable, slender, hyaline hyphae, 4-5 / in diameter. These assumed the most fantastic tendril-like forms and showed very curious connections. A spiral formation of these hyphae was very common. Probably their function is to give stability to the jelly-like contents of the apo293


ABSTRACT Genetic parameters for growth and carcass traits were estimated on the basis of the data from 3,415 heads of Hanwoo bulls tested at Livestock Improvement Main Center. The data were divided into two groups : the first period group consisted of 1,592 heads of bulls tested in individual pens from 1986 to 1990 and the second period group consisted of 1,823 heads of bulls tested in group pens from 1991 to 1996. The testing period was from 6 to 18 months of age in the first period group and 10 to 22 months of age in the second period group. The average daily gains during 6 to 12 months and 12 to 18 months were 1.01kg and 0.77kg, respectively, in the first period group and 0.80kg and 0.95kg in the second period group, and the compensated growth appeared to have occurred in the second period group. The heritability of body weight at 12 months estimated was 0.37 during the first period and 0.47 during the second period. The heritability of body weight at 18 months was 0.29 during the first period and 0.33 during the second period. The heritability of average daily gain during 6~12 months estimated was 0.26 for the first period and 0.33 for the second period. The heritability of average daily gain during 12~18 months estimated was 0.11 for the first period and 0.22 for the second period. The heritabilities of body weights and average daily gains estimated tended to be higher in the second period than in the first period. The heritability of body measurements at 12 months during the first period estimated was 0.30 for withers height, 0.25 for rump height, 0.11 for thurls width and 0.13 for chest girth. The heritability of body measurments at 12 months during the second period was 0.53 for withers height, 0.44 for rump height, 0.36 for thurls width and 0.56 for chest girth. The heritabilites of withers height, rump height, thurls width and chest girth at 18 months of age were 0.40, 0.22, 0.12 and 0.21 during the first period and 0.45, 0.42, 0.42 and 0.35 during the second period, respectively. The heritability of carcass traits estimated during the first period was 0.11 for carcass weight, 0.24 for dressing percent, 0.25 for eye muscle area, 0.18 for backfat thickness and 0.21 for carcass length. The heritabilities of carcass weight, dressing percent, eye muscle area, backfat thickness, carcass length and marbling score during the second period estimated were 0.32, 0.52, 0.33, 0.51, 0.58 and 0.31, respectively. The genetic correlations between the first and second periods estimated were higher than 0.8 for chest girth at 12 months, rump height at 18 months, carcass weight and dressing percent, but were lower for other traits.(


The paper uses the factor analytic method to discuss the investment value of the Agricultural Listed Company under financial crisis. The conclusions are as follows: firstly, the investment value of the Agricultural Listed Company is not high in general, of these, only 37.5% of the Agricultural Listed Company has investment value; secondly, the lower scores of management performance factor and capital expansion factor is the main reason for leading to the investment value of the Agricultural Listed Company no high. Therefore, agricultural listed company should seize the good opportunities of agricultural structure adjustment, the preferential policies of agricultural industrialization and high-tech development so as to effectively improve their management efficiency, solvency and capital expansion capability, and thus increase their investment value.


This study examines the problem of pricing financial assets under investment constraints using the Capital Asset Pricing Model (CAPM). Particularly, under investment constraints that limit leverage and short selling, we end up with a pricing model, where the expected returns of any risky asset, is linearly correlated with the expected returns of the market portfolio and the expected returns of options, which are non-redundant assets and their risk cannot be hedged. A positive answer to the hypothesis of the project, means that derivatives are an important explanatory factor that needs to be taken under consideration in pricing models.
Specifically, the study investigates whether the use of options instead of just their underlying asset, could lead to better results in an equilibrium model like the CAPM. From a theoretical stand point, the use of options as explanatory variables is highlighted when investors are under wealth constraints in the formation of their portfolios, a hypothesis that will also be used in this study.
Data from the 2005 to 2013 time period will be used, a period with many fluctuations in the market, due to the recent financial crisis, as well as the recent growth to the financial assets prices. Furthermore, the returns of existing and new investment strategies will be calculated using statistical packages and programming tools.


The cellular effects of MCP-1 are mediated primarily by binding to CC chemokine receptor-2. We report here that MCP-1 stimulates the formation of the lipid products of phosphatidylinositol (PI) 3-kinase, namely phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PI 3,4,5-P3) in THP-1 cells that can be inhibited by pertussis toxin but not wortmannin. MCP-1 also stimulates an increase in the in vitro lipid kinase activity present in immunoprecipitates of the class 1A p85/p110 heterodimeric PI 3-kinase, although the kinetics of activation were much slower than observed for the accumulation of PI 3,4,5-P3. In addition, this in vitro lipid kinase activity was inhibited by wortmannin (IC50 = 4.47 ± 1.88 nm,n = 4), and comparable concentrations of wortmannin also inhibited MCP-stimulated chemotaxis of THP-1 cells (IC50 = 11.8 ± 4.2 nm, n= 4), indicating that p85/p110 PI 3-kinase activity is functionally relevant. MCP-1 also induced tyrosine phosphorylation of three proteins in these cells, and a fourth tyrosine-phosphorylated protein co-precipitates with the p85 subunit upon MCP-1 stimulation. In addition, MCP-1 stimulated lipid kinase activity present in immunoprecipitates of a class II PI 3-kinase (PI3K-C2α) with kinetics that closely resembled the accumulation of PI 3,4,5-P3. Moreover, this MCP-1-induced increase in PI3K-C2α activity was insensitive to wortmannin but was inhibited by pertussis toxin pretreatment. Since this mirrored the effects of these inhibitors on MCP-1-stimulated increases in D-3 phosphatidylinositol lipid accumulation in vivo, these results suggest that activation of PI3K-C2α rather than the p85/p110 heterodimer is responsible for mediating the in vivo formation of D-3 phosphatidylinositol lipids. These data demonstrate that MCP-1 stimulates protein tyrosine kinases as well as at least two separate PI 3-kinase isoforms, namely the p85/p110 PI 3-kinase and PI3K-C2α. This is the first demonstration that MCP-1 can stimulate PI 3-kinase activation and is also the first indication of an agonist-induced activation of the PI3K-C2α enzyme. These two events may play important roles in MCP-1-stimulated signal transduction and biological consequences.


A fundamental requirement of an Environmental Management System (EMS) is to assess the significance of impacts in order to set priorities for improvement. The Environmental Aspect Register is the cornerstone of an EMS where contributions, material inventories and controls are summarised and it is this document that needs to be scrutinised and screened to identify significant impacts. Life Cycle Assessment (LCA) is an objective methodology that can be used to assess the environmental impact of a product, process or activity. This paper discusses the development of a methodology to allow the inclusion of radioactive discharges into the LCA framework. A number of specific parameters are identified which describe the fate and effect of radioactivity in the environment and these are used to derive a formula for calculating Equivalency Factors to allow a linear comparison of substances released into air and water.


Abstract : The objective of the study was to define an advanced guidance computer architecture that will permit the effective use of high-order programming languages in the definition and implementation of advanced ballistic missile missions. Part 2 of the Final Report entitled 'Guidance Computer Architecture Study', contains the selected architecture together with the SPL language and compiler considerations involved in the design, and the programming tradeoff studies. The study placed emphasis on the ability of the architecture to efficiently execute compiler generated code. A selected set of guidance and targeting equations was used as a vehicle for conducting tradeoff studies. SPL compiler generated code forms were studied for interfacing with computer functions. The size efficiency of the object code compared to that of assembly programming for traditional single address fixed point airborne computer architectures was the major design consideration. The resulting architecture is effective in satisfying other functional guidance computer system requirements (i.e. execution time and memory size) while significantly improving the size efficiency of generated object code.


Lipoma is the most common mesenchymal tumor. Majority of them are small in size, slow growing and termed as giant lipomas when they attain size of more than 10 cm in any diameter or more than 100 gm. Lipoma of the breast are rare and usually benign. The clinical and radiographic identification of breast lipoma remains challenging. Complete surgical excision with the capsule is essential to prevent recurrence.


Advances in GIS and digital remote sensing are improving our ability to obtain estimates of spatially distributed forest properties such as forest biomass or productivity. The availability of such tools for implementing models in a spatially explicit manner provides opportunities to integrate ecological or process-based models into resource management applications. This article provides guidelines for implementing such models for spatially explicit applications to forest management. Project objectives may vary greatly from one application to another, but scaling, model evaluation, error assessment, and procedural improvement are all aspects that require a common strategic approach. Three examples of implementation of spatial models dealing with the mapping of forest biomass, site index and forest productivity are also presented. The guidelines can be extended to other applications, in particular to those in resource management where either ecological modelling or the inclusion of new technologies such as ...


In this paper, the application of domestic electrolytic copper foil production line of electrolytic copper foil surface treatment system equipment, automation control system and so on are briefly introduced,analyzing the domestic leading level of frequency control of motor speed,tension control,automatic control key technology such as coiling control control principle,control of the line.


The changes in the structure and morphology of a random copolymer containing 92 mol % glycolide units and 8 mol % lactide units as a function of in vitro hydrolysis have been studied. A number of techniques, such as wide-angle x-ray diffraction, small-angle x-ray scattering, density measurements, infrared spectroscopy, and viscometry were employed in this study. The results showed that the hydrolytic attack was initiated in the amorphous areas of the polymer. After 28 days in the in vitro medium most of the amorphous areas had been chemically converted to lower-molecular-weight species such as oligomers of poly(glycolide-co-lactide). These low-molecular-weight species become water solble and are removed rapidly after day 28. Thus the fiber takes on a Swiss cheese character as the amorphous matter is hydrolyzed and eventually dissolved. As hydrolysis proceeds further, the crystalline areas of the polymer are attacked and eventually removed from the fiber by solubilization. The resulting voids in the fiber are eventually filled by a "collapse" of the structure. The role of the amorphous areas of the polymer in controlling the tensile strength of the suture is discussed.


12123 Background: Patients carrying variant alleles of DPYD that reduce activity of dihydropyrimidine dehydrogenase have unacceptably high risk of severe toxicity from systemic fluoropyrimidine chemotherapy. DPYD testing prior to systemic fluoropyrimidine treatment is standard of care across Europe and is increasingly used in USA. There is a published case report of fatal toxicity from topical fluoropyridine chemotherapy in a DPYD variant carrier, but the risk of severe toxicity in these patients is unknown. This information is critical to determine whether patients receiving topical fluoropyrimidine treatment should also undergo DPYD genetic testing. The objective of this retrospective cohort study was to determine whether patients carrying DPYD variant alleles have increased risk of severe toxicity from topical fluoropyrimidine treatment. Methods: Individuals who received topical fluoropyrimidine treatment at Michigan Medicine and had available DPYD genotype data, due to participation in the Michigan Genomics Initiative institutional genetic data repository, were eligible for this analysis. Clinical data for the first cycle of topical fluoropyrimidine treatment was abstracted from the electronic medical record by an investigator blinded to genetic data. Toxicities were graded based on the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. The primary endpoint was grade 3+ toxicity. The secondary endpoint was grade 1+ toxicity. Genotypes for five validated decreased- or null-activity DPYD variant alleles were included: DPYD*2A (rs3918290), DPYD*13 (rs55886062), DPYD p.D949V (rs67376798) DPYD HapB3 (rs56038477) and DPYD p.Y186C (rs115232898). Toxicity rates in DPYD variant carriers vs. wild-type were compared using Fisher's Exact tests. Results: 201 patients receiving topical fluoropyrimidine therapy who had available DPYD genotype data were included in the analysis. Most patients were self-reported white (97%), male (71%), and received topical fluoropyrimidine for a diagnosis of actinic keratosis (79%). As expected in a US patient cohort, 7.0% (14/201) of patients carried a DPYD variant. No patients experienced grade 3+ toxicity. Patients carrying a DPYD variant allele had nominally higher risk of grade 1+ toxicity (21.4% vs. 10.2%, odds ratio = 2.40 (95% Confidence Interval: 0.10-2.53), p = 0.19). Conclusions: Patients carrying DPYD variant alleles may have increased risk of non-severe toxicity from topical fluoropyrimidines, but the risk of severe toxicity is minimal regardless of genotype. DPYD genetic testing to prevent severe and fatal fluoropyrimidine toxicity should be reserved for patients receiving systemic treatment and need not include patients receiving topical treatment, in whom risk of severe toxicity is minimal.


The invention provides a vertical shaft tidal current generating set. The vertical shaft tidal current generating set comprises three modules, namely an upper layer platform part, a supporting frame part and an impeller part, wherein the upper layer platform part mainly comprises a generator, a gear box, a horizontal connecting shaft, a supporting platform, a supporting column and a vertical connecting shaft; the supporting frame part is formed by connecting an upper frame plate, a lower frame plate, a left frame plate and a right frame plate; and the impeller part comprises a main shaft, a spoke sleeve, a spoke, a spoke shaft, a blade, a blade shaft, a wheel disk and an adaptive attack angle control device. The invention provides the high-performance vertical shaft tidal current generating set, which has high starting and generating performances and high structural strength, can be developed towards large-scale direction, can be used below a floating platform and above a pile base and a tension leg, is convenient to produce, manufacture, install and debug, and is suitable for engineering application.


FIELD: smoking accessories.SUBSTANCE: invention relates to inhalers of flavored nicotine powder. Said nicotine powder inhaler comprises a housing extending between the mouthpiece region and the distal end portion; an air flow channel extending between the mouthpiece region and the distal end portion; a container for nicotine powder located along the channel of the air flow and containing a dose of nicotine powder containing nicotine salt and a dose of flavoring; and a vortex generator element configured to generate rotational motion in the air flow from the air flow channel, wherein the inhaler is configured to deliver a dose of nicotine powder to the user's lungs via an air stream created by inhalation at the mouthpiece region, with an inhalation rate of less than about 5 L/min.EFFECT: creating a flavored nicotine powder inhaler that is capable of delivering flavored nicotine powder to a user at an inhalation rate or airflow rate that does not exceed the inhalation rate or airflow rate in a normal smoking mode, which is similar in size and configuration to a regular cigarette and is capable of providing a metered dose of flavored nicotine and, if necessary, simultaneous delivery of a second active ingredient.12 cl, 11 dwg