The effect of compositional heterogeneity in sequence data on phylogenetic inference was first identified as a potential problem in the late 1980s and early 1990s (Chang and Campbell, 2000; Conant and Lewis, 2001; Foster and Hickey, 1999; Hasegawa et al., 1993; Klenk et al., 1994; Lockhart et al., 1992a, 1992b; Loomis and Smith, 1990; Olsen and Woese, 1993; Penny et al., 1990; Sogin et al., 1993; Tarrio et al., 2001; Van Den Bussche et al., 1998; Weisburg et al., 1989), and by 1993 the first methods had been developed to measure the extent of the problem (Lockhart et al., 1993, 1994; Steel et al., 1993, 1995) or to overcome it (Foster, 2004; Galtier and Gouy, 1995, 1998; Galtier et al., 1999; Gu and Li, 1996, 1998; Lake, 1994; Steel, 1994; Steel et al., 1993, 1995; Tamura and Kumar, 2002; Yang and Roberts, 1995). It is now widely accepted that compositional heterogeneity in aligned sequence data can mislead methods commonly used to infer phylogenetic trees, but it is still unclear (i) why phylogenetic studies based on the LogDet (or paralinear) distance (Lockhart et al., 1994; Steel, 1994) sometimes fail to recover the expected tree topology from compositionally heterogeneous alignments (e.g., Foster and Hickey, 1999; Tarrio et al., 2001), and (ii) how much compositional convergence is necessary before the phylogenetic methods fail to recover the correct topology. Using Monte Carlo simulations to address the second point, Conant and Lewis (2001) concluded that "rather extreme amounts of convergence are necessary before parsimony begins to prefer the incorrect tree." Other simulation studies have reached similar conclusions (e.g., Galtier and Gouy, 1995; Rosenberg and Kumar, 2003; Van Den Bussche et al., 1998). Based on the study by Galtier and Gouy (1995), it would appear that it is safe to use DNA for phylogenetic inference as long as the difference in GC content is less than 8% to 10%. This im-


The reactivity of thymic lymphocytes in the mixed lymphocyte reaction of the toad Xenopus laevis is already established in the 4th week after fertilization. The degree of tritiated thymidine incorporation by lymphocytes and stimulation indices were of the same order of magnitude during ontogeny. This stability of the thymocyte reactivity contrasts with other aspects of the thymus development. At metamorphosis, the number of lymphocytes in the thymus is reduced by a factor of 5, as compared to the maximum number of cells in larval stage.


In this work, a Learning-Service project that consists of working on somatosensory and special senses stimulation in people with intellectual and/or developmental disabilities is shown. This experience has been made through small and simple exercises, games or activities that allow these people to experience new sensations.  In this activity, the participants have been students of Pharmacy and Education Degree and children of a special education school. The main aim is to develop the sensory and physical faculties and promoted the functionality of the person. University students had to encourage the students of special school to use their senses. For this task Pharmacy students had the help and advice of Education students. The sanitary situation obligates to develop this activity with a video calls. For both groups of students, this experience has been a different mechanism to learn and practice using a new way of communication. All Pharmacy degree students think that this experience is has been good for their future professional activity. The teachers from the Special Education Center indicated that these initiatives are very important for their collective.


This paper is a continuation of [8], where we give a construction of the canonical Pfaff system Ω(M ` m) on the space of (m, `)-velocities of a smooth manifold M . Here we show that the characteristic system of Ω(M ` m) agrees with the Lie algebra of Aut( m), the structure group of the principal fibre bundle M̌ ` m −→ J ` m(M), hence it is projectable to an irreducible contact system on the space of (m,`)-jets (= `-th order contact elements of dimension m) of M . Furthermore, we translate to the language of Weil bundles the structure form of jet fibre bundles defined by Goldschmidt and Sternberg in [2]. 1. The characteristic system of Ω(M m) It is well known that Aut(Rm) is a Lie group whose Lie algebra is isomorphic to Der(Rm,Rm) (see [4, 5]); we are going to prove this result in a form which we will need later. The elements of Aut(Rm) are, in particular, linear automorphisms of R m; therefore if ξ̄ is the infinitesimal generator of a 1-parameter subgroup {τt} of Aut(Rm), we can associate to it the linear map ξ fromRm into itself which applies each vector P ∈ Rm into the element ξP = − lim t→0 τtP − P t = −ξ̄P I , (1.1) where I : Rm −→ Rm is the identity, which we understand as a vector valued function. The mapping which assigns to each ξ̄ the linear map ξ defined by (1.1) is an injective homomorphism of Lie algebras between the Lie algebra of Aut(Rm) and the set of linear endomorphisms of Rm, endowed with a Lie algebra structure by the commutator. Since {τt} is a group of automorphisms of R m as an R-algebra, and not only as a vector space, ξ is a derivation, as one can check easily, hence equation (1.1) establishes an injective mapping from the Lie algebra of Aut(Rm) into DerR(Rm,Rm); but the dimensions of Aut(Rm) and DerR(Rm,Rm) agree, and therefore the map ξ 7−→ ξ̄ is an isomorphism. 2000 Mathematics Subject Classification: 58A20.


The current salvage therapies for relapsed/refractory acute myeloid leukemia (AML) are unsatisfactory. Over the past 7 years, we have used two salvage regimens: fludarabine, cytarabine, and idarubicin with (FLAG‐IM) or without gemtuzumab ozogamicin (GO) (9 mg/m2 on Day 8) (FLAG‐I) in relapsed/refractory AML. Three‐quarters of patients also received concurrent G‐CSF. Seventy‐one patients were treated, 23 with FLAG‐I and 48 with FLAG‐IM. The median duration of follow‐up was 30.6 months. The treatment groups were well balanced with median ages of 48 years (range 18–70) and 47 years (range 20–68), unfavorable cytogenetics in 57% and 35%, prior allogeneic stem cell transplant in 43% and 42%, and CR1 duration <1 year in 60% and 67%, respectively, for FLAG‐I and FLAG‐IM. The complete remission (CR) rate in the FLAG‐I group was 39% with an additional 13% achieving a CRp [overall response rate (ORR) 52%]; the CR rate in the FLAG‐IM group was 29% with an additional 27% achieving a CRp (ORR 56%). The median duration of response (DOR; 16.8 vs. 8.3 months), event‐free survival (EFS; 7.4 vs. 4.1 months), and overall survival (OS; 8.8 vs. 5.0 months) trended to favor FLAG‐I over FLAG‐IM. The patients who received G‐CSF concurrent with chemotherapy had superior overall response rate (ORR; 62% vs. 29%, P = 0.026), median EFS (6.2 vs. 3.4 months, P = 0.010), and OS (8.8 vs. 3.9 months, P = 0.004) when compared with those who sequentially received G‐CSF and chemotherapy, regardless of chemotherapy regimen. The addition of GO, at this dose and schedule, to FLAG‐I failed to improve the outcomes in patients with relapsed/refractory AML. The patients who received G‐CSF concurrently with chemotherapy had improved outcomes. Am. J. Hematol., 2009. © 2009 Wiley‐Liss, Inc.


Adaptivity in sorting algorithms is sometimes gained at the expense of practicality. We give experimental results showing that Splaysort — sorting by repeated insertion into a Splay tree — is a surprisingly efficient method for in‐memory sorting. Splaysort appears to be adaptive with respect to all accepted measures of presortedness, and it outperforms Quicksort for sequences with modest amounts of existing order. Although Splaysort has a linear space overhead, there are many applications for which this is reasonable. In these situations Splaysort is an attractive alternative to traditional comparison‐based sorting algorithms such as Heapsort, Mergesort, and Quicksort.


The paper deals with the effect of moisture and temperature on the postbuckling response of a laminated composite plate subjected to hygrothermomechanical loadings. Mechanical loading consists of uniaxial, biaxial, shear, and their combinations. The distribution of temperature and moisture on the surface is considered to be uniform. The degradation in material properties due to moisture and temperature is taken into account using a micromechanical model. The mathematical formulation is based on higher order shear deformation theory and von Karman's nonlinear kinematics. The quadratic extrapolation technique and fast converging finite double Chebyshev series are used for linearization and spatial discretization of the governing nonlinear equations of equilibrium, respectively. The effects of temperature rise, moisture concentration, fiber-volume fraction, and plate parameters on buckling and postbuckling response of the plate are presented.


We propose a transmission scheme designed to increase the number of subscribers without degradation of the bit error probability in an embedded transmission method for optical code division multiple access (OCDMA) with pulse position modulation signaling (PPM). In the conventional scheme, the transmission symbols and their slot positions are embedded in the desired user's weighted positions in M-ary PPM-OCDMA. However, in the proposed scheme, only the transmission symbols are embedded in the desired user's weighted positions. We analyze the bit error rate (BER) of the proposed scheme for a Poisson photon counting process. We show that the proposed scheme can increase the number of simultaneous users compared to the conventional scheme while achieving a BER of ≤10−9 and keeping the information rate constant. © 2006 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 89(10): 55–65, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.20224


Describes the continuing "cancellation crisis" in academic libraries in both the USA and the UK. Gives current prices of academic journals in the UK. Outlines methods used to measure the use of paper journals in libraries. Details a study revealing which of these methods are currently employed by the "new universities" in the UK. Stresses the need for accountability and the importance of use measurement to validate cancellation decisions.


genetic mutation in the PHOX2B gene, is important due to the genotype phenotype correlation. Knowledge of a patient's exact mutation allows accurate prognostication and targeted screening for complications of CCHS 1 . Current guidelines 1 recommend genetic testing for CCHS consisting of PHOX2B screening with sequencing of the PHOX2B gene if the initial screen is negative and there is a high clinical suspicion. This process of testing is not readily available at all centres meaning that often samples will have to be sent internationally for testing, with associated cost and delay.


SUMMARY Theuseofalternative medicine was assessed byquestionnaire in96patients with irritable bowelsyndrome, 143patients withorganic upper gastrointestinal disorders and222 patients withCrohn's disease ofcomparable age andsex.Significantly more patients withthe irritable bowelsyndrome (16%)hadconsulted practitioners ofalternative medicine abouttheir condition thanhadpatients ineither oftheother groups.Similarly, significantly more irritable bowelsyndrome patients said theywouldconsult an alternative medicine practitioner (41%)if conventional treatment failed. Current usageofalternative medicine remedies was significantly greater intheirritable bowelsyndrome patients (11%)thaninpatients withCrohn's disease (4%) andtended tobegreater thaninpatients withorganic uppergastrointestinal disorders (6%). This study hasshownthat theuseofalternative medicine iscommon inpatients withirritable bowel syndrome andthis doesnotappear tobeexplicable intermsofthenature,chronicity or refractoriness totreatment ofsymptoms.


Personnel in the NASA Glenn Research Center Network and Architectures branch have performed a variety of research related to space-based sensor webs, network centric operations, security and delay tolerant networking (DTN). Quality documentation and communications, real-time monitoring and information dissemination are critical in order to perform quality research while maintaining low cost and utilizing multiple remote systems. This has been accomplished using a variety of Internet technologies often operating simultaneously. This paper describes important features of various technologies and provides a number of real-world examples of how combining Internet technologies can enable a virtual team to act efficiently as one unit to perform advanced research in operational systems. Finally, real and potential abuses of power and manipulation of information and information access is addressed. 1 2


In general, the transition matrix of a Markov chain is a stochastic matrix. For a system that is modeled by a Markov chain, the transition matrix must reflect the characteristics of that system. Th...


Faunal assemblages from the Refaim Valley, Israel, dating to the Early Bronze IV (also termed Middle Bronze I/Intermediate Bronze Age) were analyzed. The complex at which remains were found comprised two houses and a cemetery. Its economy was based primarily on caprovine husbandry, but other domestic stock was also kept. It is possible that some level of secondary product utilization, beyond meat exploitation, also occurred. The faunal analysis supports the excavators' contention that the site represents a permanent settlement (Edelstein and Eisenberg 1984; 1985). Differences between animals kept at this site and those kept at a contemporaneous site in the Negev are indicative of differences in subsistence strategies between populations exploiting the northern regions and those exploiting the southern, more arid, environmental zones.


The present invention relates to a kind of integrated highly reliable high-precision Long-term Monitoring Systems, it gathers and edits unit including two changes of current, two integrated controllers, interchanger, two monitoring computers, several first sensors and several second sensors, the present invention is by acquiring traditional data, coding, transmission, the improvement and innovation of demodulation process method, based on serial communication interface and Industrial Ethernet, solve system equipment complicated composition, precision is low, the problem of long-term reliability deficiency, it is highly reliable to realize system, the function of high-precision and long term monitoring, the present invention is at integrated aspect, Integration Design is carried out to system core equipment, reduce equipment composition, reduce system complexity;In terms of transmitting real-time, the transmission of data is completed based on universal serial bus+Ethernet, it is ensured that the propagation delay time does not influence to actually use;In terms of long-term reliability, by taking Redundancy Design and other reliability design measures to key equipment, product stream time is improved.


Type of funding sources: Public grant(s) – EU funding. Main funding source(s): This study was supported by the European Research Council (Starting grant 716509) to D.A. Pijnappels.

 Recently it was demonstrated how the heart itself could be enabled to quickly restore its rhythm by realizing a biologically-integrated cardiac defibrillator (BioICD) through modification and subsequent expression of ion channels in cardiomyocytes [1]. By incorporating these frequency-dependent depolarizing ion channels, abnormal cardiac rhythm could be rapidly detected and terminated to restore sinus rhythm in a fully biological and shock-free manner. However, from a translational point of view, it remains unclear how such rhythm restoration can be realized via ion channel gene therapy.

 To explore and understand the importance of the distribution and number of BioICD-expressing cardiomyocytes in realizing fully biological restoration of cardiac rhythm.

 To this purpose, two different realistic gene therapy configurations, i.e. those corresponding to systemic and local transgene delivery, were tested in a digital twin of human ventricular cardiac monolayers. For the systemic delivery group, BioICD-expressing cells were homogeneously distributed over the tissue with fixed total expression percentage. For the local delivery group, circular areas were given BioICD-expressing cells, randomly patterned in a Gaussian distribution. In both groups spiral waves were initiated and subsequently studied for 10 seconds. For systemic delivery, an additional set of simulations was performed for an adapted BioICD ion channel with a slower opening and faster closing rate.

 Upon comparing both gene therapy methods, the systemic approach showed a gradually increasing arrhythmia termination chance with increasing BioICD-expression percentage, while local delivery never resulted in termination. Instead, local delivery resulted in islands of ionic heterogeneity, causing attraction and anchoring of the spiral waves in a size and distance-dependent manner. Building on the results of the systemic approach, different ion channel parameters were tried, which resulted in normal rhythm being restored in all cases for >50% BioICD expressing cells. Time till termination was inversely related to the percentage, resulting in only 4.3s and 2.5s for 50% and 100%, respectively. Regarding termination, it was observed that conduction blocks appeared throughout the tissue and subsequently connected to force arrhythmic waves to terminate, while this process remained incomplete in the <50% groups.

 This study reveals that wide-spread distribution of BioICD-expressing cardiomyocytes is required for the realization of fully biological self-restoration of cardiac rhythm, of which the efficiency is ion-channel-dynamics- and dosage-dependent. Local expression, however, results in stabilization of spiral wave activity. Further exploration of this emerging concept of biological cardioversion may not only expand our understanding of cardiac arrhythmias, but also pave the way to breakthrough advances in arrhythmia management.


A general description of the Steinbeis Foundation and its characteristics is analysed in this paper. Combined with the actual environment of China, we discuss and offer some inspirations that could be used to promote the development of science and technology transfer organizations in our country.


Blind equalization is a technique of adapting an equalizer without the need of a training sequence. The constant modulus algorithm (CMA) is one of the first known blind equalization algorithms. The cost function of the CMA exhibits local minima, which are the primary cause of the ill-convergence of the CMA. Anchoring the CMA improves the performance of the CMA in terms of ill-convergence. This technique is used with the linear and the decision feedback equalizers. It is shown that the adaptive equalizer will always remove intersymbol interference (ISI) as long as the channel gain exceeds a certain critical value.<<ETX>>


Micelle formation in binary mixtures of surfactants is studied using a coarse-grained molecular simulation. When a vesicle composed of lipid and detergent types of molecules is ruptured, a disk-shaped micelle, the bicelle, is typically formed. It is found that cup-shaped vesicles and bicelles connected with worm-like micelles are also formed depending on the surfactant ratio and critical micelle concentration. The obtained octopus shape of micelles agrees with those observed in the reported cryo-TEM images (S. Jain and F. S. Bates, Macromolecules, 2004, 37, 1511). Two types of connection structures between the worm-like micelles and the bicelles are revealed.


Conventional ways of thinking about the gender of war and peace center on the too‐comfortable view of women—and especially mothers—as embedded in particular ways of being‐in‐the‐world that presumably make them resistant to wars and receptive to peacekeeping. Yet in many cases, this theory doesn't hold true. Instead, aspects of the experience of mothering—especially under conditions of scarcity, famine, oppression, and political disruption—can both instruct and allow women to readily surrender their sons (and their husbands) to war, violence, and death. There's a maternal ethos of "acceptable death" without which political violence and wars of all kinds would not be possible.


While the massacre of peaceful Algerian demonstrators by French police on October 17, 1961, has been thoroughly studied by historians and is well known to the general public thanks to a sprawling corpus of novels, plays, songs, films, bandes dessinées, and other retrospective representations, to date there has been no careful archaeology of the event's original audiovisual archive from 1961. This article takes up that challenge in two stages: first, by identifying the photos and newsreel footage shot on the night of October 17, specifying the circumstances of their production, (non)distribution, and impact in the immediate aftermath of the massacre; second, by surveying how key elements of the original archive were recycled over the following sixty years to serve in turn as surrogates for and complements to other sources of knowledge about this infamous and long-dissimulated crime d'état.


ABSTRACT This research focuses on reducing the toxic emissions from the exhaust by installing a turbulence enhancement unit just before the three-way catalytic converter. This unit creates turbulence in the gases flowing through the combustion chamber when fitted with the Tata Indica V2 diesel engine (1405cc). Turbulence leads to the rising in the contact area of the exhaust gases going to the catalytic converter for the reactions to take place. Experimentally, it was found that swirl venturi gives the best results in the overall emission test. Although the overall best device is swirl venturi, swirl blades also give better results on higher rpm of the engine. This paper shows the detailed research on the emission test performed.


Based on the data of the basic information in 1990 and 2005 remote sensing,GIS and previous studies on landscape pattern of wetland in Liaohe River delta,the security of wetland in Liaohe River delta is studied by using the indexes on landscape pattern and of vulnerability of landscape types,such as,fragmentation,isolation and dominance.In the 1990s,the increasing resources exploitation aggregates the fragmentation on Liaohe River delta,which increases the landscape dominance and decrease the diversity.From 1990 to 2005,the disturbance on main paddy field,weed field,beach increased while the landscape ecological security de-creased,which demonstrate that the disturbance from the human beings increase.On the whole,landscape security of whole research region has decreased for 15 years.The previous research on ecological security focused on the environment vulnerability and the protective methods about the ecosystem.While there is few researches relate to the wetland ecological security.It is a new field to study the sustainable development on landscape ecology.The essence of content on the study is to discuss method for quantitative landscape ecological security.By using the landscape ecology on the ecological security,the landscape structure,function,the change tendency and its inner factors are revealed,which provide the scientific evidence on the protection and natural resource exploitation of wetland in Liaohe River delta,and developed and enriched the theories and methods of Chinese ecological security.


Power-electronics based Compact Fluorescent Lamps (CFLs) have been proven to reduce electrical energy consumption for lighting purpose. As in common power-electronics-based electrical devices, CFLs can be categorized as non-linear loads. Therefore, the input current has a non-sinusoidal waveform and contains harmonics. This paper discusses the advantages and disadvantages of CFL application and proposes the attachment of THD value to the product package in order to improve the marketing policy. Total Harmonic Distortion (THD) is a method used to find the percentage value between the total harmonic components and their fundamental components. The percentage of THD causes the greater risk of damage to equipment due to harmonics that occur in current and voltage. Laboratory testing shows that a CFL sample has THD of the input current as high as 67.7%. This THD is relatively high and may degrade the electrical power quality. Moreover, it could lead to the misreading of electrical power and energy meter. Several experiment results are shown and analyzed to confirm the validity of the discussed matter.


In the process of establishing Hubei provincial experimental teaching demonstration center,the experimental teaching center of chemistry of China University of Geosciences built a teaching system of chemical experiments,which is of unified planning,four levels,classified implementation and open teaching,according to the training thought of the university,i.e."the thickening foundation,strengthening ability,widening adaptation,emphasizing innovation".


Functioning adrenocortical oncocytomas are extremely rare and most reported patients are 40–60 years of age. Functioning adrenocoritcal oncocytomas are rare in children. We report a case of functioning adrenocortical oncocytoma in a 16-year-old female girl presenting with primary amenorrhea and virilisation. She presented with deepening of the voice and excessive hair growth, and elevation of plasma testosterone and dehydroepiandrosteronesulphate with normal catecholamines. We are describing the biochemical, radiological, operative and post-operative findings of this case. The tumour, which was well-encapsulated and circumscribed with 17 × 8 × 5 cm in size, was completely separated from kidney. The gross and microscopic study confirmed a case of adrenocortical oncocytic neoplasm of uncertain malignant potential. This tumour mass was removed successfully and patient was asymptomatic in routine follow-up.


This paper introduces the characteristics of the ship form for a deepwater pipelaying crane vessel,and studies structural design of this typical ship. It analyzes the longitudinal strength by mass distribution and wave load. Then it analyzes the local strength of the stem structure by 3D finite element analysis method. Finally,it analyzes and concludes the critical design factor and technical difficulties of this kind of working vessels.


The big data about music history contains information about time and users' behavior. Researchers could predict the trend of popular songs accurately by analyzing this data. The traditional trend prediction models can better predict the short trend than the long trend. In this paper, we proposed the improved LSTM Rolling Prediction Algorithm (LSTM-RPA), which combines LSTM historical input with current prediction results as model input for next time prediction. Meanwhile, this algorithm converts the long trend prediction task into multiple short trend prediction tasks. The evaluation results show that the LSTM-RPA model increased F score by 13.03%, 16.74%, 11.91%, 18.52%, compared with LSTM, BiLSTM, GRU and RNN. And our method outperforms tradi-tional sequence models, which are ARIMA and SMA, by 10.67% and 3.43% improvement in F score.Code: https://github.com/maliaosaide/lstm-rpa


Background: With point-of-care testing, (POCT) we obtain results quickly, reliably and with a minimal amount of sample. We noticed that occasionally hemoglobin Hb results obtained by POCT compared with those obtained by laboratory testing differ significantly, especially the Hb values that are lower or higher than average.
Methods: We included 130 samples of capillary and venous blood in our study. With POCT method we determined Hb from both types of samples and with laboratory testing we determined Hb from venous samples.
Results: We included 103 samples from blood donors who came to blood donation and 27 samples from patients after major orthopedic surgery. Capillary Hb concentration ranged from 70 to 201 g /L. We found that there was a good correlation between the values obtained with POCT of both, capillary and venous samples (R2 = 0.949). Even more reliable was the determination of Hb from venous samples measured by POCT and laboratory testing (R2 = 0.982). When we compared the average deviations in different groups of Hb concentrations of capillary samples, we found that it was the lowest in the group of middle values (120–140 g /L) where it was -0.4 and higher where the deviation was larger (in the group up to 120 g/L it was 1.2, in the group between 141 and 160 g /L it was -3.6, in the group between 161 to 180 g /L it was -8.6 and in the group over 180 g /L even -14.3). Conclusion: We found that POCT is a suitable method for the determination of Hb, which – when implemented correctly – provides reliable test results for the selection of blood donors and decision making for transfusion. However, the reliability of the results obtained with higher Hb values is smaller, therefore we recommend laboratory testing. When this is not feasible, Hb determination with POCT in a venous blood sample is better than in a capillary one


Robust control theory considers a fundamental and practically important issue in power system environment. It turns out that many of the simplest questions are very
difficult to solve, but researchers have made considerable progress over the last twenty years. Recent techniques of robust control theory, based on convex optimization over linear matrix inequalities (LMIs) might change this. In this project, robust design of power system stabilizers is considered. A new approach is presented that utilizes recently developed techniques based on LMI for mixed H 2/H design. The design is easily carried out by solving a standard LMI problem. Simulation results on a single machine infinite bus system illustrate the technique, and results are compared with Nonlinear Based Optimization approach.


According to the engineering example of foundation reinforcement about a High-rise building in the lotus village in Hexi of Nanjing,the article introduces the application of anchor static pressure pile in high-rise building foundation reinforcement engineering.The construction technology of foundation reinforcement with anchor static pressure pile has the advantages of simple structure,convenient method and low cost,as well as which can be promoted in the use of similar engineerings.


A new species of Arctobaiera, A. renbaoi is described based on well-preserved long shoots bearing either helically arranged elongate leaves or dwarf shoots with a bundle of elongate leaves and scales at bases, as well as detached leaves. All leaves are sessile with entire lateral margins and veins branched only at the lower part. They vary considerably in shape. Most commonly, they are entire, spathulate or paddle-shaped and with a more or less obtuse apex, but sometimes shallowly or even more deeply bilobed. The leaves are aniphistomatic with alternate stomatal and non-stomatal strips on both sides. Stomata are haplocheilic (mostly anomocytic) and monocylic to incomplete dicyclic, consisting of sunken guard cells and normally only slightly thickened subsidiary cells of irregular shape and size.
The new species shows some resemblance with the type-species A. flettii Florin, although only dwarf shoots were found in the latter and no anatomical details of leaves and dwarf shoots are known in the present species. The major distinctions between the two species are in the leaf shape and possibly in distribution of stomata. According to Florin, A. flettii bears leaves of the hypostomatic type. Comparisons have also been made between the present species with some other ginkgophytic leaf genera. It is believed that A. renbaoi is a new member of Czekanowskiales, though its fructification remains unknown.


Preface Acknowledgments 1. Introduction 2. An overview of the sound-symbolic system 3. Sound symbolism of mimetic adverbs based on CV Roots 4. Sound symbolism of mimetic adverbs based on CVCV Roots 5. Historical considerations of mimetic words 6. Conclusion Appendices A. CV-based mimetic adverbs B. CVCV-based reduplicative mimetic adverbs C. Mimetic adverbs /CV(C)CVri/ D. CVCV-Based mimetic adverbs with palatalization References Index.


In this study I aim to write what can be the already known but forgotten bases of renewed (actually "retro") regional politics —. How can city-village categories be integrated and what are the regional economical bases of city oriented development policies. After that I summarize the changes of EU regional politics concerning our topic. By describing Hungarian history of this topic I aim to show that these questions are not new ones, we have to give 21th century answers to historical debts. New thing in "retro" regional development policy is the policentical development based on city regions; what integrates rural places in a new way and recreates the old city-village dichotomy. Concentrated decentralization must be helped by correcting accessibility.


Wafer throughput is of great importance to the semiconductor production facility. The problems of financial and spatial considerations magnified by aging fabs and industry downturns are directing focus to improving existing capacity and away from purchasing new tools. Wafer handler hardware upgrades, software upgrades, and improved operation procedures were implemented on three Varian EHP-220 implanters and one EHP-500 implanter to achieve higher capacity. This was accomplished without adversely affecting implant process parameters, tool uptime, or product uniformity. This paper presents two stages of improvements along with the data for corresponding increase in tool capacity and retention of tool and process reliability.


The invention relates to a sound absorption composite structural material and a preparation method thereof. The material comprises the components of a chlorinated polyethylene/seven-hole hollow polyester staple fiber composite material and a perforation plate, wherein the mass ratio of chlorinated polyethylene to a seven-hole hollow polyester staple fiber is 4 to 1. The preparation method comprises the following steps of: (1) perforating stainless steel according to a triangular distribution mode, cleaning the surface of the stainless steel, and thus obtaining the perforation plate; and (2) flatly coating an adhesive on the surface of the chlorinated polyethylene/seven-hole hollow polyester staple fiber composite material, and thus obtaining the material. The sound absorption composite structural material can effectively absorb sound energy, and two different sound absorption mechanisms of a porous material and film resonance vibration can be fully used for expanding a sound absorption effect field in a cooperation way along with the increase of the number of structural layers; and the material is easy to prepare, and the material and the preparation method are suitable for industrial production.


Neural network models of space perception using binocular vision are presented to find out how the convergence angle and the bipolar latitude are mapped onto the depth sensation. It is considered that the horopter and parallel distance alleys, which have been thought to be phenomena in psychology, are actually structural characteristics of signal processing in the human neural network, resulting from the learned transformation of binocular eye movement information into a subjective orthogonal coordinate system. Psychological and physiological knowledge offers several space perception models with different signal processing structures. In learning simulation experiments, the models generated horopter, parallel alley, and distance alley results which were similar to those of a human being. On the basis of these results, it is concluded that the signal processing system in human space perception uses the essential signal space for each perception as the signal space for interaction between signals.<<ETX>>


sory retina. The pathologic process includes degeneration and breaks in Bruch's membrane (a barrier layer separating the retina and choroid), which allows choroidal vessels to invade the space beneath the retina (choroidal neovascularization) and leak fluid or blood. Until a recent study by the Macular Photocoagulation Study Group, supported by grants from the National Eye Institute, the treatment of exudative macular degeneration by obliteration of choroidal neovascularization with argon laser photocoagulation had not been proved. A multicenter controlled clinical trial was undertaken in 1980 to answer the question "Is argon laser photocoagulation useful in preventing severe visual loss in eyes with evidence of macular degeneration and a choroidal neovascular membrane outside the fovea?" As few as 1 in 20 patients screened met the eligibility criteria. Of those patients selected, however, by 18 months after entry in the study, 60% of the patients whose eyes were untreated had lost six or more lines of vision compared with only 25% of those whose eyes had been treated. Twice as many patients whose eyes were treated had a visual acuity better than 20/40 at the most recent visit. Persistence of the treatment benefit remains to be determined. Patients at greater risk, such as those who have lost central vision from exudative macular degeneration in one eye, should be examined periodically. Because persons are in the treatable stage for only a short time after onset of symptoms, it is important for both physicians and patients to be alert for symptoms of distortion, scotoma or blurred vision that may indicate the presence of choroidal neovascularization. Further investigation is being done in hopes of finding other laser wavelengths that may increase the success rate in this vision-threatening disease. RONALD J. COLE, MD


An isolation and suspension medium for house fly, Musca domestica L., muscle mitochondria consisting of sucrose, EDTA, citrate, α -ketoglutarate, and succinate results in high efficiency for oxidative phosphorelation, adequate respiratory control, and maximal sensitivity to uncouplers. This system permits further studies with the oxygen electrode on the mode of action of uncouplers as insecticide chemicals


ABSTRACT Cultivated peanut, the second most economically important legume crop throughout the United States and the third most important oilseed in the world, is consistently threatened by various diseases and pests. Sclerotinia blight, (causal agents Sclerotinia sclerotiorum (S. sclerotiorum) and Sclerotinia minor Jagger (S. minor))is a major threat to peanut production in the Southwestern U.S., Virginia, and North Carolina and can reduce yield by up to 50% in severely infested fields. S. sclerotiorum has now been reported in areas of eastern New Mexico and west Texas where all U.S. grown Valencia peanuts are produced, commonly in organic cropping environments. Host plant resistance provides the most effective solution to managing Sclerotinia blight, especially in organic systems where pesticide use is not an option for disease control. To date, no Valencia cultivars with Sclerotinia blight resistance have been released. In this study, the Valencia peanut core germplasm collection was genotyped with a Si...


Outcomes for adolescents and young adults (AYA) might be considerably different from children and older adults with acute leukemia (AL). Patients in this transitory period tend to be considered at higher risk for poorer outcomes. However, AYA is still underrepresented in most hematopoietic stem cell transplant (HSCT) studies. Recent evidence shows superior outcomes for AYA with acute lymphoblastic leukemia (ALL) using pediatric rather than adult first line chemotherapy regimens. The aim of this study is to analyze outcomes of umbilical cord blood transplant (UCBT) in AYA patients with ALL or acute myeloid leukemia (AML) after myeloablative conditioning regimen (MAC).
 Eligibility criteria included patients with AL aged 15-25 (median 19) years, transplanted between 2004 and 2016 in EBMT centers, with single or double UCBT as first allogenic transplantation after MAC regimen and reported to Eurocord. A total of 504 patients were included. Primary endpoint was overall survival (OS).
 Median follow-up for survivors was 38 months (1 month-11 years). Median time from diagnosis to UCBT was 11 months (1 month-17 years) (interquartile range 5-29 months). Diagnosis was ALL in 59% (n=297) and AML in 41% (n=207); 64% of patients were male. Disease status at UCBT were 42% in 1st complete remission (CR) (n=203), 2nd CR in 38% (n=183), and advanced disease in 20% (n=96).
 Fifty eight percent of patients (n=293) received single and 42% (n=211) double UCBT. Cyclophosphamide + TBI ± fludarabine (45%) was the most frequently used conditioning regimen. Anti-thymoglobulin (ATG) was used in 54% and GVHD prophylaxis was cyclosporine A + mycophenolate mofetil in 44% of patients. Median nucleated cell dose at collection was 3.63 (range 0.9-9.0) X107/Kg for single and 5.25 (range 2.3-10.6) X107/Kg for double UCBT.
 The 3-year OS was 45±2%; 3-year leukemia free survival (LFS) was 41±2% and refined GVHD free/relapse free survival (rGRFS) was 32±2%.
 OS was similar in ALL and AML (45±3% vs 45±4%, p-value=0.69). According to disease status at UCBT, 3-year OS was 54±4% for patients in CR1, 48±4% for CR2 and 20±4% for advanced disease (p-value<0.001).
 Cumulative incidence function (CIF) for neutrophil engraftment at day-60 was 88% [95% confidential interval (CI) 85-90] in a median time of 24 days. CIF of acute GVHD grade II-IV at day-100 was 28% (95%CI 24-32) and out of the 233 patients with aGVHD, 73 (21%) had grade III-IV.
 The 1-year CIF of chronic GVHD was also 28% (95%CI 24-33) and out of the 124 patients with cGVHD, 52 (42%) had the extensive form.
 The 3-year CIF of transplant related mortality (TRM) was 31% (95%CI 24-33). The 3-year CIF of relapse was 28% (95%CI 24-32), and according to disease status at UCBT, relapse was 28% (95%CI 21-34) for patients in CR1, 24% (95%CI 18-31) for those in CR2 and 37% (95%CI 27-47) for advanced disease.
 Main causes of death were relapse (41%) and TRM (57%, mainly infections and GVHD).
 In multivariate analysis, disease remission at UCBT (HR 0.46, 95%CI 0.32-0.66, p-value<0.001) and transplant performed in more recent years (HR 0.75, 95%CI 0.62-0.90, p-value=0.002) were independently associated with increased OS. A similar effect was observed for LFS (recent transplantation: HR 0.80, 95%CI 0.66-0.95, p-value =0.01 and disease remission: HR 0.51, 95%CI 0.36-0.72, p-value <0.001). On the other hand, negative CMV serology (HR 0.77, 95%CI 0.61-0.99, p-value =0.042), recent transplantation (HR 0.85, 95%CI 0.73-0.99, p-value=0.49) and disease remission (HR 0.61, 95%CI 0.44-0.84, p-value =0.002) were significantly associated with increased rGRFS. For grade II-VI aGVHD, ATG use (HR 0.52, 95%CI 0.32-0.82, p-value=0.005), single UCBT (HR 0.63, 95%CI 0.42-0.96, p-value=0.03), and recent transplant (HR 0.76, 95%CI 0.59-0.98, p-value=0.034) reduced the risk. However, no factor was associated to cGVHD.
 This large series of AYA patients with AL provides detailed information on UCBT for this particular cohort with results comparable with other sources of HSCT.
 Due to the lack of information on pre-transplant chemotherapy (pediatric versus adult protocols), we were unable to evaluate its effect on outcomes. Nevertheless, this study contributes to a better understanding of HSCT for an age group that is not thoroughly described in most publications. Demonstrating the feasibility of UCBT in AYA patients is important to facilitate the decision of stem cell source selection when a more standard donor is not available.

 Hough: University College London Hospital's NHS Foundation Trust: Employment. Angelucci:Vertex Pharmaceuticals Incorporated (MA) and CRISPR CAS9 Therapeutics AG (CH): Other: Chair DMC; Celgene: Honoraria, Other: Chair DMC; Jazz Pharmaceuticals Italy: Other: Local ( national) advisory board; Novartis: Honoraria, Other: Chair Steering Comiittee TELESTO Protocol; Roche Italy: Other: Local (national) advisory board. Bader:Medac: Patents & Royalties, Research Funding; Neovii: Research Funding; Riemser: Research Funding; Cellgene: Consultancy; Novartis: Consultancy, Speakers Bureau.


The restrictions of computer aided detection(CAD) systems for mammography screening, the acute significance of early detection of breast most cancers and the greater impact of The fake or false evaluation of patients energy researchers to analyze Deep learning(DL) techniques for mammograms identification. mammograms image the background (Noise) Can disturb the detection of breast most cancers and decrease the charge of accuracy inside the pc aided evaluation (CAD).Hence the Pre-processing of mammogram pictures may be very important inside the procedure of breast most cancers analysis due to the fact it can reduce the variety of false tremendous. DNN Can offer discrimination picture representation, it known as features, by using successive utility of linear filters, non-linear activation characteristic, normalization and pooling operations, for that reason averting the need to design such capabilities manually. By Using Pectoral Muscle Removal(PMR) it will avoid False positive , there are two different views: Craniocaudal view (CC) and Mediolateral Oblique(MLO). The primary column offers perspectives of the right breast that is Right Craniocaudal view (RCC) and Right Mediolateral Oblique view (RMLO). The other column offers two perspectives of the left breast i.e Left Craniocaudal view (LCC) and Left Mediolateral Oblique view (LMLO). and we are using some techniques in PMR. By using Pectoral Muscle Removal we can easily increases accuracy and avoid 90% of false detection. The classification of DNN algorithm using ResNet technique gives a better results.


This paper, with the development of Chinese cinema from 1949 to 2000, analyzes the temporal appearances, the cultural features and the rhetorical devices. Meanwhile it portrays the process of the transformation of Chinese cinema from monistic political mode, to pluralistic artistic mode, to popular industrial mode. The author thinks, the new Chinese cinema will replace "the cinema in new China", become one of the components of the new society objectives, and provide the objectives with cultural imaginations, and with new starting points of economic growth as well.


The platelet‐derived growth factor (PDGF) modulated growth response of the MG‐63 human osteosarcoma cell line, which neither expresses c‐sis mRNA nor secretes a PDGF analogue, was characterized. Scatchard analysis demonstrated that the MG‐63 cells have 23,000 receptors per cell with a kd of 5 × 10−11 M. The receptor became phosphorylated, in a PDGF concentration‐dependent manner, when 32P‐orthophosphate‐labeled cells were treated with PDGF for 3 h at 4°C. The phosphorylated receptor was identified by autora‐diography and gel electrophoresis after isolation of the 32P‐labeled receptor using a solid‐phase monoclonal antibody directed against phosphotyrosine. Binding of the receptor to the antibody was inhibited by 5 mM phenyl phosphate, further suggesting that PDGF stimulated tyrosine‐specific receptor autophosphorylation. In addition, treatment of MG‐63 cells with PDGF for 3 h at 37°C induced a 7.5‐fold increase in c‐myc mRNA accumulation as analyzed on Northern gels. However, MG‐63 cells grew equally well in either serum‐(which contains PDGF) or plasma‐(which does not) supplemented medium. Furthermore, PDGF did not stimulate DNA synthesis in growth arrested MG‐63 cells, nor did it potentiate DNA synthesis modulated by somatomedin C. Thus MG‐63 cells are a naturally occurring cell variant in which PDGF stimulates c‐myc expression but does not modulate mitogenesis.


Single-phase, high-purity NaMn1/3Co1/3Ni1/3PO4 of the orthorhombic maricite mineral type is prepared by sol-gel and combustion routes starting with stoichiometric mixtures of NaOAc, Mn(OAc)2, Co(OAc)2, Ni(OAc)2, NH4H2PO4, and for sol-gel processing citric acid or PVP as chelating agent, (80°C, pH 3.5, 1.


In this paper a solution is presented which guarantees we avoid the connectivity paradoxes related to the Jordan Curve Theorem for all multicolor images. Only one connectedness relation is used for the entire digital image. We use only 4-connectedness (which is equivalent to 8-connectedness) for every component of every color. The idea is not to allow a certain `critical configuration' which can be detected locally to occur in digital pictures; such pictures are called `well-composed.' Well-composed images have very nice topological properties. For example, the Jordan Curve Theorem holds and the Euler characteristic is locally computable. This implies that properties of algorithms used in computer vision can be stated and proved in a clear way, and that the algorithms themselves become simpler and faster.


The purpose of the present study is to identify the effects of monetary policy and macroeconomic shocks on the dynamics of the Brazilian term structure of interest rates. We estimate a near-VAR under the identification scheme proposed by Christiano et al. (1996, 1999). The results resemble that of the US economy: monetary policy shocks flatten the term structure of interest rates. Nevertheless, we find that monetary policy shocks in Brazil appear to explain a significant larger share of the dynamics of the term structure than in the USA. Finally, we also study the importance of standard macroeconomic variables, as GDP, inflation and specially, a measure of country risk for the dynamics of the term structure in Brazil. The empirical evidence allows us to infer that as the Brazilian term structure of interest rates increase its maturities, the more important will macroeconomic shocks be to its determination.


Some concerns on "Efficacy and complications after delayed fixation of femoral neck fractures in children." J Orthop Surg (Hong Kong), 2020, 28(1) by Wu C et al. DOI: 2309499019889682 I have read with great interest the article in your journal by Wu C et al. titled "Efficacy and complications after delayed fixation of femoral neck fractures in children." There is an ongoing debate in the literature on the effect of various factors on outcome of pediatric femoral neck fractures with no consensus in near future. The authors have done a wonderful study correlating avascular necrosis (AVN) rates with method of reduction, age, displacement and type of fracture. However, there are some points which need clarification from the authors for a better understanding of this article.


The light-induced bistability under permanent irradiation (LITH: light-induced thermal hysteresis), due to the competition between light irradiation and self-accelerated relaxation, shows crucially rate-dependent hysteresis. Major and minor hysteresis loops for [Fe(PM-BiA)2(NCS)2] spin crossover compound have been measured. Using appropriate master equations, distribution data from the first-order reversal curves diagrams of the purely thermal hysteresis, and parameter values previously derived from relaxation curves, we could simulate the LITH experimental data. The tunneling contribution to the relaxation rate revealed to be a key factor for the final agreement.


Ranking is a process of prioritization. Priorities, as measurement rather than pure guessing, can be derived from paired comparison judgments that generalize on ratios of actual measurements. Paired comparisons involve the selection of the smaller of the two objects being compared as the unit and estimating how many multiples of that unit the larger object is with respect to an attribute they share. In this paper, it is shown how priorities are derived as the principal right eigenvector of a pairwise comparison matrix and several examples are given to illustrate how the process works.


The aim is to study the empirical relevance of performance management systems in the public sector, based on the performance management systems framework.A qualitative approach was chosen, making three case studies of Swedish municipalities by conducting personal interviews. The municipal chief executive, municipal CFO and a financial manager at a department were chosen at every municipality, providing us with diversified as well as accurate information. The interviews were based on the PMSs framework developed by Ferreira and Otley (2009), giving a broad and detailed description of the systems. This information, together with the theoretical framework, was then processed, leading up to the analysis and conclusions.Pursuant to the new public management, performance management is a relatively new concept in the public sector. The three studied municipalities all have relatively new PMSs, showing that this area is empirically relevant to study. As expected, the municipalities displayed both positive and negative sides of their systems, described in more detail in the paper. The PMSs framework is considered a useful tool in this study, making it relevant in the public sector. Still, both benefits and drawbacks are found, presented together with possible improvements.


The paper presents the impact of cepstrum computation in Linear Predictive Coding for audio signals that belong to wildlife areas. In this sense, we compare on diverse number of features both Linear Predictive Coding coefficients and Linear Predictive Cepstral coefficients for the audio signal characterization. The scope is to identify the appropriate number of coefficients for both methods, together with the best method that can provide a certain accuracy within a defined framework, such as an intruder detection system. The experimental results prove that the Linear Predictive Cepstral coefficients method provides a better accuracy for tested scenarios than Linear Predictive Coding. The highest accuracy is obtained using the order of 16 for the predictor filter together with the KStar classifier.


This study examined the cognitive and emotional reactions of 477 Israeli high school students to the assassination of Prime Minister Yitzhak Rabin (immediately after the event as well as 5 months later) and to a series of terror attacks. The respondents' reactions to the two events were compared as a function of gender and political orientation. About 50% of the respondents who changed their political views immediately after the assassination reverted to pre-event attitudes 5 months later. Emotional reactions to the assassination showed substantial fading after 5 months, with extent of fading unaffected by gender or political orientation. The intensity of emotional reactions was affected by political orientation: Although Rabin's supporters and his opponents reacted with equal intensity to the terror attacks, supporters reacted with the same intensity to Rabin's assassination, whereas opponents' reactions to the assassination were less intense. Language: en


The use of new generation preparations at patients with generalized periodontitis promotes the prevention of possible complications after operative interventions into periodontal tissues.


Case report This Indian girl was born normally in 1983 in Zambia to distantly related parents. Her milestones till the age of 3 years were normal; she could say up to 20 words and she had become toilet-trained. At 3 years of age, however, she developed several episodes of chest infection and gastroenteritis. Following this, her motor and mental development gradually deteriorated. After her family moved to the UK she was referred to the hospital paediatricians. Her gait was unsteady, she was uninterested in toys, she had lost acquired language and she was not toilet-trained. Her weight and height were below the 3rd centile, she had coarse facial features, a protruding tongue, kyphosis and contracture of the right elbow. There was no hepatosplenomegaly. The muscles appeared to be of normal tone and her reflexes were normal. There was no corneal clouding and her vision was normal. When she was 9 years old, she was referred to the Dermatology Department of the Leicester Royal Infirmary because ofa 'nappy rash', noticed for a year. On examination she had multiple vascular papules typical of angiokeratomas on the genitalia, scattered on the extremities and on the tongue. There were also strikingly increased vascular markings on the palms and soles.


Microstructure and tensile deformation behavior of interstitial-free (IF) steel subjected to near-cryogenic (−150°C to −100°C) rolling followed by annealing have been investigated. Twining has been found to be the dominant mode of deformation during rolling. Both the rolled and annealed sample exhibited limited work hardening due to high matrix resistance. In the rolled sample cleavage, nuclei acted as potential fracture initiation site. Annealing has resulted in effective blunting of cleavage nuclei giving rise to large total elongation due to prolonged damage growth process.


There are lots of tries to make a combination between the technology development which is fast arisen and cultural phenomenon which imply in it. We called this research area as the cultural computing or cultural modeling. In this paper, we examine the cultural user interface design, especially cultural design structure based on the contents considering the research trend of the cultural modeling. To design of the contents based on the culture, there is a need to draw a structure of the cultural feature for the contents. To do this, we combine Hofstede`s cultural dimensions model with the data of contents and then we suggest cultural index of content(CiCo). Furthermore, we draw national index of cultural content(NiCC), through conjoining CiCo with preference pattern of content consumption for the nations. Suggested CiCo and NiCC are based on Hofstede`s model, however they are improved approximately 10% of the explanatory of model than the Hofstede`s.


Three-dimensional tracking of multiple objects from multiple views has a wide range of applications, especially in the study of bio-cluster behavior which requires precise trajectories of research objects. However, there are significant temporal-spatial association uncertainties when the objects are similar to each other, frequently maneuver, and cluster in large numbers. Aiming at such a multi-view multi-object 3D tracking scenario, a current statistical model based Kalman particle filter (CSKPF) method is proposed following the Bayesian tracking-while-reconstruction framework. The CSKPF algorithm predicts the objects' states and estimates the objects' state covariance by the current statistical model to importance particle sampling efficiency, and suppresses the measurement noise by the Kalman filter. The simulation experiments prove that the CSKPF method can improve the tracking integrity, continuity, and precision compared with the existing constant velocity based particle filter (CVPF) method. The real experiment on fruitfly clusters also confirms the effectiveness of the CSKPF method.


These days, you don't have to go far to hear a little something about renewable power. And in the Tri-Cities, you needn't look beyond your own backyard. At the Bioproducts, Sciences, and Engineering Laboratory--BSEL--on Washington State University's Richland campus, scientists are doing some cutting edge research on the conversion of biomass to fuels and value-added products that are traditionally derived from petroleum. The facility, built by the State of Washington, houses scientists from both Pacific Northwest National Laboratory and WSU Tri-Cities.


By use of the method in the previous paper [J. Phys. Soc. Jpn. 53 (1984) 3918], we study the Anderson localization in a one-dimensional half-filled extended Hubbard model with randomness. A transition from localization into delocalization takes place as the attractive interaction for superconductivity increases. It is shown that the effect of localization on singlet superconductivity (SS) is stronger than that on triplet superconductivity (TS) due to the large quantum fluctuation of TS compared with that of SS.


Frank Cooksey, rehabilitation is an attitude of mind. All good doctors, whatever their sphere of influence, must be prepared to participate in the rehabilitation of the patients for whom they have responsibility by ensuring that proper use is made ofthe existing services no matter who is responsible for their provision. Although this should occur as a matter of routine, the ignorance of so many of our medical colleagues is quite frightening. A recent television programme dealing with aids for the disabled began with a virtuoso performance on his Possum machine by a gifted quadriplegic and only later went on to deal with many of the common problems of daily living. This was a sincere attempt to educate the public but implicit was the suggestion that facilities for such simple assessments of disability only existed in special rehabilitation centres. We must, both as a specialty and as individuals, accept some measure of the blame for the fact that even now many of our medical colleagues are ignorant of the routine work done and facilities available in their own hospitals. At long last a commonsense broadly-based specialty of 'rheumatology' has the opportunity to meet the challenges which it should properly face within the total spectrum of locomotor medicine and to triumph therein. Isaak Walton's 'Compleat Angler' has been described as a welldisguised tract for troubled times written 'to persuade men to study to be quiet'. It is my earnest hope that the compleat rheumatologist will now do likewise.


To develop engines and power plants, the issues of improving engines through the use of a new type of turbomachines – turbo-compressors with general impeller (TCG) have been considered. There is another name for this type of turbomachine – a single-disk turbo-compressor (STC), although for bladed machines it is not the disk that is important, but the entire impeller. For example, a diagram of the simplest small-sized gas turbine engine using TCG is shown. For the systematization of relatively efficient TCG schemes, a classification has been developed and is given in the article, of possible schemes for a turbocharger with a common impeller. To implement one or another flowing pattern in the impeller, it is necessary to select the appropriate shape of the impeller blades and the location of the nozzle, exhaust, suction and discharge channels relative to each other. Depending on the direction of movement of the gas flows, turbo-compressors with a common impeller may have two flow patterns in interscapular impeller space – direct-flow and counter-flow. If the directions of the gas and airflow coincide to the axis of rotation of the impeller, then the flow pattern in the TCG is direct-flow, with opposite flow flows it is countercurrent. For carrying out the enlarged gas-dynamic calculation of TCG, formulas are given that make it possible to calculate the circumferential force arising on the blades of the impeller in the compressor and turbine working channels of the TCG. Also, formulas are given, with correction factors, for calculating the power factor of the compressor part and the load factor of the turbine part. In the process of computational and experimental studies, the characteristic of the compressor part of the TCG experimental model was obtained. If the ratio of the grating width to the average diameter of the working channel is overestimated, it is necessary to supplement the formula for calculating the compressor power factor with a correction factor. The test results of the compressor part of the TCG experimental model showed good agreement between the calculated and experimental values. Studies have shown that a turbocharger with a common impeller can be used as of gas turbine engines and in a turbo-supercharging system of a capacity internal combustion engine with not high supercharging.


We analyze a model of conflict with endogenous choice of effort, where subsets of the contenders may force the resolution to be sequential: First the alliance fights it out with the rest and , in case they win, later they fifht it out among themselves.


The analysis of physiochemical parameters of food grains from different districts of Haryana and Punjab was carried out emphasizing on selenium levels. The parameter like concentration of selenium in different food grains was obtained. The observed results were analyzed with the help of arithmetic mean, standard deviation and mean deviation of the respective food grains. The observed concentration of selenium shows a marked variation in the samples from various districts of Haryana and Punjab.


Accurate operation and high performance of the open field line plasma surrounding the field reversed configuration is crucial to achieving the goals of successful temperature ramp up and confinement improvement on C-2W. Knowledge and control of the open field line plasma requires extensive diagnostic efforts. A suite of diagnostics, which consists of microwave interferometry, dispersive spectroscopy, and spatial heterodyne spectroscopy, is being developed to measure electron density, ion temperature, and particle outflow velocity at various locations along the open magnetic field lines. A detailed overview of these diagnostics is presented.


BK polyomavirus (BKPyV) replication causes nephropathy and premature kidney transplant failure. Insufficient BKPyV‐specific T cell control is regarded as a key mechanism, but direct effects of immunosuppressive drugs on BKPyV replication might play an additional role. We compared the effects of mammalian target of rapamycin (mTOR)‐ and calcineurin‐inhibitors on BKPyV replication in primary human renal tubular epithelial cells. Sirolimus impaired BKPyV replication with a 90% inhibitory concentration of 4 ng/mL by interfering with mTOR–SP6‐kinase activation. Sirolimus inhibition was rapid and effective up to 24 h postinfection during viral early gene expression, but not thereafter, during viral late gene expression. The mTORC‐1 kinase inhibitor torin‐1 showed a similar inhibition profile, supporting the notion that early steps of BKPyV replication depend on mTOR activity. Cyclosporine A also inhibited BKPyV replication, while tacrolimus activated BKPyV replication and reversed sirolimus inhibition. FK binding protein 12kda (FKBP‐12) siRNA knockdown abrogated sirolimus inhibition and increased BKPyV replication similar to adding tacrolimus. Thus, sirolimus and tacrolimus exert opposite effects on BKPyV replication in renal tubular epithelial cells by a mechanism involving FKBP‐12 as common target. Immunosuppressive drugs may therefore contribute directly to the risk of BKPyV replication and nephropathy besides suppressing T cell functions. The data provide rationales for clinical trials aiming at reducing the risk of BKPyV replication and disease in kidney transplantation.


This document summarizes the perspectives of the author(s) on the at6 tributes that are generally regarded as desirable in a journal article in the area of 7 pavement science and engineering. These perspectives are distilled from several 8 years of experience as author(s), reviewer(s), and editor(s) of peer-reviewed jour9 nal articles. The attributes listed in this paper are intended to inspire emerging 10 researchers and serve as a reminder to more seasoned researchers, what we as a 11 community should aspire to and achieve. 12 It is important to recognize a few disclaimers before moving forward. First, 13 the purpose of this document is not to provide an exhaustive list of topics 14 or processes to arrive at an award winning journal article. Simply put, this 15 document is not a recipe for a paper but a catalog of ingredients and ideas to 16 inspire high quality papers. 17 Second, the ideas presented and discussed in this document are restricted to 18 peer-reviewed journal articles. Conference papers, reports, and presentations, 19 are equally important forms of communication for scholarly work but are not 20 the focal point of this document, although many of the attributes discussed here 21 may apply. 22 Third, this is a living document. The wisdom and experience of the collective 23 will continue to evolve and change with time. Therefore, it is only natural that 24 this document will and should evolve with time. 25 Fourth, the author(s) of this article do not claim that their scientific work 26 or authored articles is exemplary nor do they claim that their scientific articles 27 work represent a perfect embodiment of the ideas presented in this document. 28 On the contrary, this document was intended as an exercise to learn, share, and 29 document to the extent feasible, some of the ideas and best practices based on 30 the perspectives of the author(s). 31


The mithan or gayal (Bos [Bibos] frontalis), a domesticated bovine found previously to play an unusual role in the socio-religious life of various hill tribes of the Indo-Burma borderlands, is considered as it fits into the life of the Aka, a tribal people of Arunachal Pradesh, India.


There are many problems in human resource(HR) allocation of state-owned commercial banks at present,such as problematic preferences.According to the requirements of strategic HR management,banks need to discard the influence of traditional HR managment,fulfill comprehensive HR planning,allocation,development and management,and optimize HR allocation to fit for the demand of strategic development.The detailed contents are as follows:adjusting HR allocation structure conforming to development strategy,emphasizing superior HR allocation according to classification management principle,and insisting value orientation to give priority to key positions' HR demands;strengthening the marketing function of foreground and market expansion ability,and improving the HR allocation of customer managers to meet the needs of bank's development strategy;emphasizing the consistency and coordination of target policy in HR management function,such as training and appraisal,to suit the needs of HR allocation.


It is truly an honor to be part of this festschrift that recognizes J. David Richardson MD, as the former editorin-chief of The American Surgeon (2005-2019). This article could also be entitled "A Historical Vignette of Dr J. David Richardson: A Horseman, A Mentor, A Friend, and The Ultimate Academic Surgeon." I first met Dr Richardson in the summer of 1980 at the Louisville General Hospital (Figure 1). He was a young member of the faculty who came to Louisville from the University of Texas at San Antonio, while I was a research fellow at the Price Institute of Surgical Research working for Drs Hiram Polk, the Chair of the Department of Surgery, and Lewis Flint (Figure 2). Dr Richardson and I had an immediate connection that has lasted for 40 years. In those days, Dr Polk used to lead bedside rounds every Friday afternoon, and Dr Richardson frequently attended. I was always impressed by his deep knowledge of surgery, wisdom, and endless curiosity for advances in surgery, especially in the field of trauma. He facilitated discussions that were truly visionary. In addition, Dr Richardson felt strongly that general surgeons should not specialize to the point of exclusion of other components of surgery. He used to describe himself as a broad-based surgeon "who happens to do trauma as well." On multiple occasions, he said "I trained in an era when surgeons did a variety of big operations, and I did not want the diaphragm to be a limitation. So I did noncardiac thoracic surgery as well as vascular, broad-based general surgery, and trauma." That diversity in his practice is reflected in his board certifications in general surgery and cardiothoracic surgery and with added qualifications in vascular surgery and surgical critical care.


Shorea roxburghii or locally known as meranti temak nipis is from the family of Dipterocarpaceae. Generally, this species is harvested for its timber and resin. Improvement through the selection of plus tree study has been initiated with the main objective is to provide high-quality planting materials. Apart from the project, an initial experiment on the growth performances of the seedlings of S. roxburghii involving growing media treatments has been conducted. This study was conducted to evaluate the effect of different growing media on the growth performances of the seedlings of S. roxburghii. Five different growing media treatments were tested, Treatment 1: Topsoil; Treatment 2: Topsoil (3): Sand (1); Treatment 3: Topsoil (3): Compost (1); Treatment 4: Topsoil (2): Sand (1): Compost (1); and Treatment 5: Topsoil (1): Sand (2): Compost (1). The experiment was laid out in Completely Randomized Design (CRD) and for each treatment, a total of 100 seedlings were tested. The growth data (height) were taken at the initial experiment, after a month, after three months and after six months old. Findings showed that there were significant differences among the five tested treatments with p < 0.005. Treatment 3 had the highest height increment after 6 months (16.64 cm) and after 3 months (5.18 cm). This was followed by Treatment 4, also for twice consecutive times after 6 months (15.39 cm) and after 3 months (3.11 cm). The results also indicated that all the top three best seedlings performances were from the growing media treatments that contain compost as the media composition. However, there was no clear indication that the seedlings needed sand in the growing media composition. Therefore, it is concluded that early growth performances of the seedlings of S. roxburghii were positively affected by the combination of topsoil and compost.


This paper proposes a simultaneous scheduling and binding approach for resource and interconnect reduction in high-level synthesis. The scheme incorporates the operation scheduling into functional unit (FU) and register binding, targeting the reduction of both resource and interconnect reduction. A simplified weighted and ordered compatibility graph (SWOCG) based binding algorithm is also proposed and runs tens of times faster than the WOCG based binding algorithm. The experimental results show that our proposal achieves 4% to 15% reduction in resource usage and interconnect reduction, and also runs 5X faster compared to previous works.


Accurate measurement of emissions (i.e. volume flow rate multiplied by concentration) is vital to the control and reduction of air pollution. We quantify the uncertainty of flow measurements by S-type pitot tubes in narrow exhaust stacks (diameter l 0.5 m) in support of recent European Union (EU) regulations for emissions from medium-size combustion plants. The contribution of blockage and wall effects to the uncertainty budget is evaluated. The aim of this thesis is to characterize flow uncertainty and to aid the development of more accurate measurement methods for volume flow rates in narrow exhaust stacks. This thesis will provide the scientific basis for implementation of EU regulations concerning emissions from medium-size combustion plants. Characterization of flow fields in narrow exhaust stacks is key to accurate volume flow rate measurements. We use numerical simulations to study the mean velocity profile and turbulence statistics of fully developed turbulent flow. To investigate the impact of wall effects on measurement uncertainty, we simulate the flow eld around an S-type pitot tube in close proximity to the stack wall. In addition, we conduct S-type pitot tube measurements at various wall-distances and bulk velocities. Throughout this thesis, we use several uncertainty quantification techniques to evaluate the uncertainty of numerical simulations and experiments. Studying spatial variation in measurement uncertainty gives insight in the most suitable locations for S-type pitot tube measurements in narrow exhaust stacks. The results of this thesis suggest that wall effects dominate over other sources of measurement uncertainty in the near wall region. Throughout the measurement plane, the combined uncertainty of measurement error sources exceed the impact of blockage. We recommend to determine volume flow rates in narrow exhaust stacks by S-type pitot tube measurements in the stack center. A correction factor can be determined to compute the volume flow rate in a narrow exhaust stack from the maximum flow rate in the stack center.


Because of a close relationship between detrital flux variations and magnetic susceptibility (MS) flux (MS cm−3 of bulk sediment multiplied by the linear sedimentation rate) variations in the southeast Indian basin of the southern ocean, MS flux profiles have been used to examine the spatial and temporal detrital flux changes in this basin during the last climatic cycle. Results indicate a general increase in detrital material input during the coldest periods, suggesting a widespread phenomenon, at least on the basin scale. Mineralogical data, geochemical data, and 87Sr/86Sr isotopic ratios have been used to determine the origin and transport mechanisms responsible for increased detrital flux during glacial periods. Mineralogical and geochemical data show that these glacial "highs" are due to increases in both Kerguelen-Crozet volcanic and Antarctic detrital inputs. The 87Sr/86Sr isotopic composition of the >45-µm fraction indicates that the Kerguelen-Crozet province contributes to at least 50% of the coarse particule input to the west. This contribution decreases eastward to reach less than 10%. These tracers clearly indicate that the Crozet-Kerguelen province was a major source region of detrital in the western part of the basin during glacial times. In contrast, material of Antarctic origin is well represented in the whole basin (fine and coarse fractions). Because of the minor amount of coarse particles in the sediments, volcanic particles from Kerguelen and crustal particles from Antarctica have most probably been transported by the Antarctic bottom water current and/or the Circumpolar deepwater current during glacial periods as is the case today. Nevertheless, the presence of coarse particles even in low amount suggests also a transport by ice rafting (sea-ice and icebergs), originated from both Kerguelen and Antarctic sources. However, the relative importance of both hydrographic and ice-rafting modes of transport cannot be identified accurately with our data. During low sea level stands (glacial maximum periods), increasing instability and erosion of the continental platform and shallow plateaus could have resulted in a more efficient transfer of crustal and volcano-detrital material to the Southeast Indian basin. At the same time, extension of the grounded ice shelves over the continental margins and increase in the erosion rate of the Antarctic ice sheet could have induced a greater input of ice rafted detritus (IRD) to southern ocean basins. Enhancement of the circumpolar deepwater current strength might have also carried a more important flux of detrital material from Kerguelen. However, an increase in the bottom water flow is not necessarily required.


We introduce a planar, triple-self-aligned double-gate FET structure ("PAGODA"). Device fabrication incorporates wafer bonding, front-end CMP, mixed optical/e-beam lithography, silicided silicon source/drain sidewalls, and back gate undercut and passivation. We demonstrate double-gate FET operation with good transport at both interfaces, inverter action, and NOR logic.


Theories of agenda setting claim that political entrepreneurs must broaden their bases of support in order to place new issues onto the formal agenda. This paper takes that claim seriously by examining the role of black protest and descriptive representation in securing white recognition of black policy issues. Making use of a new data set that provides measures of media attention and congressional bill sponsorship from 1948 to 1997, I show that both protest and descriptive representation were instrumental in gaining white recognition of black policy demands, culminating in the passage of the 1965 Voting Rights Act. However, the potency of protest and descriptive representation has lessened in response to the black social and political advancement of the post-civil rights era. It seems that black strategies of con∞ict expansion have become victims of their own success.


In this work, we focus on the multiplicity of singular spectrum for operators of the form $A^\omega=A+\sum_{n}\omega_n C_n$ on a separable Hilbert space $\mathcal{H}$, for a self-adjoint operator $A$ and a countable collection $\{C_n\}_{n}$ of non-negative finite rank operators. When $\{\omega_n\}_n$ are independent real random variables with absolutely continuous distributions, we show that the multiplicity of singular spectrum is almost surely bounded above by the maximum algebraic multiplicity of eigenvalues of $\sqrt{C_n}(A^\omega-z)^{-1}\sqrt{C_n}$ for all $n$ and almost all $(z,\omega)$. The result is optimal in the sense that there are operators where the bound is achieved. Using this, we also provide effective bounds on multiplicity of singular spectrum for some special cases.


Organ‐sparing radical cystectomy offers selected patients with bladder cancer the opportunity to maintain sexual and urinary function without compromising oncological outcomes.


We discuss the controversy and challenges of the origin of green luminescence centers in 2D CsPb2Br5 and 0D Cs4PbBr6 and suggest several new experimental techniques to resolve the controversy and identify their underlying nature.


OBJECTIVES: To determine the prevalence and factors associated with use of potentially inappropriate medications (PIMs) in older adults undergoing surgery.


BENJAMIN HAGER: SODA, WATER, AND CONVENIENCE: AN EVALUATION OF THE MEXICAN SODA TAX This thesis seeks to evaluate the Mexican soda tax of 2014 by exploring the reasons for the tax and the underlying factors that the tax seems to ignore. This soda tax, in particular, was implemented to address obesity by curbing the consumption of sugary soft drinks due to the large quantities consumed by the Mexican populous. However, as this thesis shows there are some potential pitfalls in this type of obesity prevention policy. By exploring potable water data from the World Bank, the rural and urban noncommunicable disease rates of two Mexican states, and the penetration of levels of the OXXO convenience store in each state compared to the obesity rates, an understanding of what a soda tax may ignore has been discovered. The results from exploring this data reveal that Mexico significantly lags behind other countries in terms of access to completely safe water, and there appears to be some urban and rural divide, especially in terms of income. It also reveals that more urban areas are suffering from higher rates of weight related non-communicable diseases. Finally, the OXXO penetration level data demonstrates that high densities of convenience stores may be correlated with higher obesity rates. In general this data shows that soda taxes can help curb consumption. However, in terms of real measurable changes to the health of the country, overweight rates and health care expenditures are still on the rise. Simply put, the cheap alternative to soda, water, appears to not be completely accessible for all populations. Additionally, rural regions with less obesity that rely on soda as a water alternative may be negatively affected by the soda tax, and convenience stores that sell other highly calorically dense foods are still incredibly accessible to the population, especially in regions with high obesity rates. Furthermore, it appears that the tax revenue from the soda tax is not assisting in improving water infrastructure. For this reason, certain issues should be addressed by the government to ensure the tax is working effectively and equitably for all regions of the country.


One thousand yuan is a small amount of money to most people, especially those living in China's well-off cities. But it is an incredible amount of money to women living in China's western, poverty-stricken areas. Thousands of such women have used that amount of money to escape poverty and renew their confidence in the future.


Internship is one of the most important parts in the process of professionals training in higher vocational colleges.This essay advances that "people-oriented" practice-on-duty students management platform should be established,including "enterprises' full involvement",establishment of moral education tutors' platform to fit out professional tutors throughout the process of practice-on-duty,construction of school-enterprise cooperation mechanism by party and League organization,erection of practice moral education network information system and psychological counseling platform,etc.


Since I began studying Kanaky New Caledonia and other French Pacific territories more than a decade ago, I have tried to do what I can to encourage more dialogue across the artificial barriers created by colonial languages in the Pacific, especially between speakers of English and French. Despite some networking by activists and institutions of various kinds, linguistic colonialism has often tended to divide inhabitants of Oceania into relatively separate Anglophone and Francophone circuits. Perhaps no other issue highlights this lingering problem better than nuclear testing. The US and British atomic tests ended in the early 1960s, but the French tests did not begin until 1966 and lasted thirty years, spanning the era of decolonization in the South Pacific. French nuclear testing aroused public protest across the region, and many critics saw it as another aspect of ongoing colonial rule in French Polynesia and Kanaky New Caledonia (which has strategic nickel resources), despite active independence movements in both territories. After a last round of tests in 1995‐1996, France closed down its Centre d'Experimentation du Pacifique, and, with the United States and Britain, signed the South Pacific Nuclear Free Zone Treaty of 1985. Paris has also granted more autonomy to French Polynesia and New Caledonia and has tried to improve diplomatic relations, cultural exchanges, and economic aid and trade with other Pacific countries. Given some recent crises in Anglophone Pacific states, however, France has vowed not to "abandon" its territories to disorder, the way it claims that "Anglo-Saxon" colonizers have done. In early 2002, Jean-Marc Regnault, a historian at the University of French Polynesia, sent me an article that he had coauthored and had accepted for publication in French in the Revue d'Histoire Diplomatique. He asked if I knew of an English-language journal that would consider


A population register is an inventory of residents within a country, with their characteristics (date of birth, sex, marital status, etc.) and other socio-economic data, such as occupation or education. However, data on population are also stored in numerous other public registers such as tax, land, building and housing, military, foreigners, vehicles, etc. Altogether they contain vast amounts of personal and sensitive information. Access to public information is granted by law in many countries, but this transparency is generally subject to tensions with data protection laws. This paper proposes a framework to analyze data access (or protection) requirements, as well as a model of metadata for data exchange.


DOI: 10.21276/sjmps.2018.4.9.12 Abstract: Atherosclerosis is one of the major causes of increased morbidity and mortality associated with coronary artery disease, cerebrovascular accidents, and peripheral vascular diseases. Dyslipidemia is one of the important causes that result in atherosclerosis. The incidence of atherosclerosis has been on the rising recently. Therefore prevention of dyslipidemia can decrease the development of atherosclerosis. Aims: The study was undertaken to determine the efficacy of atorvastatin alone and its combination with omega-3 fatty acids in the management of hyperlipidemia in patients attending a tertiary care hospital. Methods: This study was a cross-sectional prospective study conducted in the Department of Pharmacology and General Medicine, Kakatiya Medical College and Hospital, Warangal. The patients were selected from those visiting General Medicine OPD and diagnosed with hyperlipidemia. Sixty patients in the age group of 20 – 70 yrs, were recruited based on inclusion and exclusion criteria. They were divided into two groups. The Group I included the patients receiving Tab. Atorvastatin 10mg/day and Group II Atorvastatin 10mg/day plus Cap Omega-3 fatty acids 600mg/day for the duration of six months and follow up were done every month. Efficacy of treatment was assessed by the changes in laboratory parameters of Total cholesterol, Triglycerides, HDL-C, LDL-C, and VLDL-C. Results: The efficacy of combination therapy i.e., Atorvastatin plus Omega3 fatty acids showed a statistically significant rise in HDL cholesterol with the mean percentage difference of 4.24% when compared to monotherapy with Atorvastatin. The efficacy of other parameters like total cholesterol (TC), LDL cholesterol, VLDL cholesterol, and triglycerides (TG'S) levels with the low dose of omega-3 fatty acids in combination therapy was not statistically significant and produced nearly identical alterations in serum lipoprotein levels when compared to monotherapy. Conclusion: Although statins are being used as first-line therapy for hyperlipidemia and in patients with elevated triglycerides. For patients with elevated LDL-C and low HDL-C combination therapy appears to be a better option. Thus omega-3 fatty acids may be a potential supplement for combination therapy apart from niacin and fibrates.


In the framework of the DISWall research project, funded by the European Commission, a new reinforced masonry system, made with horizontally perforated unit where the horizontal reinforcement is laid and vertically perforated units for the confining columns with vertical reinforcement, was purposely developed for typical low-rise residential buildings, to withstand in-plane actions. Squat and slender specimens, made with this construction technique, were tested under in-plane cyclic shear compression loads, in order to analyze the shear and flexural behaviour of the proposed reinforced masonry walls. According to the experimental results, a numerical research to evaluate reduction of elastic response of masonry walls due to their hysteretic behaviour was carried out. The response of SDOF systems with given ultimate ductility was determined through non-linear dynamic analyses, for a range of natural periods that characterize the elastic phase of unreinforced load bearing masonry buildings. In the present contribution, the results of the cyclic in-plane tests and the analytical model developed to reproduce the cyclic behaviour are presented, and the conclusions coming from the dynamic analyses carried out are introduced.


The invention belongs to the technical field of food processing, and particularly discloses a tea bag capable of lowering the blood sugar level. The tea bag capable of lowering the blood sugar level comprises, by weight, 10-30 parts of dendrobium candidum, 10-20 parts of tartary buckwheat, 10-15 parts of flower buds of panax notoginseng, 10-20 parts of soda-apple night-shade herbs, 5-15 parts of safflower, 5-15 parts of flos sophorae, 5-10 parts of ganoderma lucidum, 3-10 parts of american ginseng, 5-15 parts of cyclocarya paliurus and 3-10 parts of fiveleaf gynostemma rhizomes or herbs. According to the tea bag, the above raw materials are reasonably collocated, all the raw materials achieve a good synergistic effect through the given composition proportion, and the effect on the aspect of lowering the blood sugar level is obvious.


[Objective] This study aimed to clone and analyze the cDNA of ATPase β subunit gene from Eleutherococcus senticosus.[Method] A pair of homologous primers was designed according to the chloroplast ATPase β subunit gene sequences of the known species;then the gene cDNA of E.senticosus were amplified by RT-PCR and compared with that of the known species;its structure was predicted finally.[Result] 1 099 bp of ATPase beta subunit cDNA of E.senticosus which encodes 366 amino acids was amplified by RT-PCR.Sequence comparison and structure prediction showed that amino acids encoded by the ATPase beta subunit gene of E.senticosus shared the highest homology,up to 96.41% with that of Oryza sativa.In the secondary structure,the protein contained 171 alpha helixes accounting for 46.72%,53 extended strands accounting for14.48%,27 beta sheets accounting for 7.38% and 115 random coils which took up 31.42%.The amino acids 262-271 were the symbolic site of ATPase β subunit.The whole peptide chain had no obvious hydrophobic region and was primarily confirmed as a hydrophilic protein.[Conclusion] The cNDA of ATPase β subunit gene cloned from E.senticosus in this study will provide important reference for learning the effect of energy metabolism on secondary metabolism,structure and function of ATPase in E.senticosus.


The microstructure and mechanical properties of hot-pressed composites with a different sintering temperature have been studied. The size of matrix grain and Cu dispersion in composites increased with increase in sintering temperature. Fracture toughness of the composite sintered at high temperature exhibited an enhanced value. The toughness increase was explained by the thermal residual stress, crack bridging and crack branching by the formation of microcrack. The nanocomposite, hot-pressed at , showed the maximum fracture strength of 707 MPa. The strengthening was mainly attributed to the refinement of matrix grains and the increased toughness.ЀĀЀ會ĀЀヨ⨀亙Ā؀會Ā؀㢖ヨ⨀袐亙ࠀĀࠀ會Āࠀ邖ヨ⨀墑袭Ā᐀會Ā᐀ヨ⨀삐袭᐀Ā저會Ā저䂗ヨ⨀ₑ亙ഀĀ᐀會Ā᐀颗ヨ⨀뢑亙Ā᐀會Ā᐀ヨ⨀肓亙瘀瀀ꀏ會Ā䢘ヨ⨀墑袭Ā᐀會Ā᐀ꂘヨ⨀袭Ā㰀會Ā㰀ヨ⨀袒袭Ā㈀會Ā㈀備ヨ⨀ₓ袭Ā᐀會Ā᐀ꢙヨ⨀뢓袭Ā᐀會Ā᐀šヨ⨀傔袭Ā저會Ā저墚ヨ⨀袭Ā저會Ā저낚ヨ⨀邏袭Ā저會Ā저࢛ヨ⨀⢐袭


Abstract Background Acute pancreatitis (AP) is the largest contributor to diabetes of the exocrine pancreas. However, there is no accurate predictor at the time of hospitalisation for AP to identify individuals at high risk for new‐onset diabetes. Objective To investigate the accuracy of indices of glucose variability (GV) during the early course of AP in predicting the glycated haemoglobin (HbA1c) trajectories during follow‐up. Methods This was a prospective longitudinal cohort study of patients without diabetes at the time of hospitalisation for AP. Fasting blood glucose was regularly measured over the first 72 h of hospital admission. The study endpoint was the HbA1c trajectories ‐ high‐increasing, moderate‐stable, normal‐stable ‐ over two years of follow‐up. Multinomial logistic regression analyses were conducted to investigate the associations between several common GV indices and the HbA1c trajectories, adjusting for covariates (age, sex, and body mass index). A sensitivity analysis constrained to patients with non‐necrotising AP was conducted. Results A total of 120 consecutive patients were studied. All patients in the high‐increasing HbA1c trajectory group had new‐onset diabetes at 18 and 24 months of follow‐up. Glycaemic lability index had the strongest significant direct association (adjusted odds ratio = 13.69; p = 0.040) with the high‐increasing HbA1c trajectory. High admission blood glucose, standard deviation of blood glucose, and average real variability significantly increased the patients' odds of taking the high‐increasing HbA1c trajectory by at least two‐times. Admission blood glucose, but not the other GV indices, had a significant direct association (adjusted odds ratio = 1.46; p = 0.034) with the moderate‐stable HbA1c trajectory. The above findings did not change materially in patients with non‐necrotising AP alone. Conclusions High GV during the early course of AP gives a prescient warning of worsening HbA1c pattern and new‐onset diabetes after hospital discharge. Determining GV during hospitalisation could be a relatively straightforward approach to early identification of individuals at high risk for new‐onset diabetes after AP.


The influence of protecting groups on the β-sheet-structure stability of protected peptides was studied in organic solvents. α-Amino groups, carboxyl groups, and side-chain functional groups of model peptides were protected by availably used protecting groups. The difference between the solubilities of model peptides was investigated by the solvent-titration method using infrared (IR) absorption spectra. The β-sheet-structure-stabilizing potentials (SPβ) of each protecting group showed similar behaviors, except for Npys, Mts, and Z2. The result exhibits that the values of the protected peptide are almost independent of the kinds of their protecting group.


This paper presents an analytical model for parallel volume rendering of large datasets using GPU-based clusters. The model is focused on the parallel volume rendering and compositing stages and predicts their performance requiring only a few input parameters. We also present vl3, a novel parallel volume rendering framework for visualization of large datasets. Its performance is evaluated on a GPU-based cluster, weak and strong scaling are studied, and model predictions are validated with experimental results on up to 128 GPUs.


Pharmacy and Health. The nursing programs, the programs affiliated with usu, and continuing education programs are all coordinated by the RMCOEH Director. Supervision of the occupational medicine residency, industrial hygiene and safety program, and research areas is shared by the Director of RMCOEH and the Chief of the Division of Occupational and Environmental Health in DFCM. Currently, the RMCOEH Director and Division Chief are the same person. The Chief of the Division is responsible for RMCOEH faculty appointments in DFCM in the College of Medicine. An administrator reports directly to the Director of RMCOEH, and assists in planning budgets, preparing grants and contracts, fund-raising and solving the day-to-day operational problems. Research grants and contracts are submitted through the Division of Occupational and Environmental Health or the Pulmonary Disease Division, and the appropriate departmental and college channels. The RMCOEH is housed on one floor of a building adjacent to the University of Utah Health Sciences Center, and plans are being developed for additional research space. There are 25 fullor part-time faculty in the Center, and another 25 faculty participate to a lesser extent in the teaching and research programs.