1. The content playback apparatus comprising: playback control unit which controls the content playback related to the linked type and including a plurality of scenarios, each of which comprises content data and control information relating to reproduction of content data; imodul receiving control information, which receives the control information, the reproduction control unit controls the content playback of the associated type, performing playback of content data in accordance with the control information, which includes event information used for a transition from the current script to another stsenariyu.2. Device to play content according to claim 1, wherein the information about the event, part of the control information includes information that is used for control information transfer destination scenario in which the receiving module receives the control information control information transfer destination script based on the information used to obtain the control information transfer destination script, and wherein the reproduction control unit controls the transition of scenes Aria, reproducing content data transition destination scenario in accordance with the control information destination script perehoda.3. Content playback apparatus according to claim 2, wherein the control information obtaining unit performs the transfer of information between the user authentication scenarios, adding authentication information


Attacks that take place online most frequently take the form of phishing scams. Attackers attempt to gather user data without the consent of any such user through emails, URLs, and any other link that sends a viewer to the a dubious page where a consumer is persuaded to start taking specific actions that can successfully complete an attack. An attacker has the opportunity to gather vital information about the victim during these attacks, which they can use to presume the victim's identity & carry out tasks that only the victim should have been able to carry out, such as making purchases, sending messages to the other people, and simply attempting to access the victim's info. Many studies have been done to discuss potential defenses against these assaults. This study employs three algorithms for machine learning to ascertain whether such a web page is phishing. In the experiment, software that analyzes web page URLs to distinguish between legitimate & phishing websites is used to try to prevent attacks using these models which have been trained to utilize URL-based features. The accuracy, recall, and F1 Score of the random forest classifier's performance from the observations were 97.5%, 99.1%, and 97.3%, respectively. The proposed model is quick and effective because, unlike earlier studies, it only relies on the URL and doesn't conduct analysis using any other sources.


This article approaches the main aspects of depression on contemporaneity and aims to distinguish it from mourning and melancholy. For this we take as theoretical axis the notion, by us postulated, of narcisic belief, object by excellence of the depressive symptom kind here approached. We search to demonstrate that the hegemonic presence of the narcisic belief on the subjective constitution may take to a form of reaction to loss that distinguishes from mourning and melancholy. This kind of depression presents itself as one of the main forms of psychic suffering that appear on contemporary psychoanalytic clinic.


Membrane-free stem cell extract (MFSCE) derived from adipose tissue has been reported to have anti-inflammatory activity. In the present study, we investigated the effects of MFSCE on atopic dermatitis (AD)-like skin inflammation using house-dust-mite-sensitized NC/Nga mice. Topical application of MFSCE significantly ameliorated AD-like clinical symptoms including erythema, dry skin, edema, excoriation, erosion, lichenification, and scratching. In addition, the levels of serum immunoglobulin E and inflammatory cytokines were decreased by MFSCE treatment. Furthermore, treatment with MFSCE inhibited the increase in epidermal thickness, infiltration of mast cells, expression of interleukin (IL)-4, IL-10, interferon-γ, tumor necrosis factor-α, thymus, and activation-regulated chemokines in the dorsal skin of NC/Nga mice. In conclusion, MFSCE effectively suppressed AD-like manifestations preclinically, systemically, and topically. Our study suggests that MFSCE may be a useful natural product for AD therapeutic strategies.


Corner reflector is a typical passive electronic jamming. In this paper, in order to reject corner reflector jamming effectively, the extreme learning machine algorithm is proposed to be used to discriminate ship and corner reflector base on the radar high resolution range profile (HRRP) differences, and the ship, the array corner reflectors and the combined corner reflectors electromagnetic models are built to verify the feasibility of this method. The simulation results show that there are average correct recognition rates all over 91% in SNR of ranging 0dB~15dB using the algorithm proposed with the average training time of 0.25 seconds. Compared to the support vector machine and deep belief network algorithm, the recognition rate and the training speed of the method proposed both have a better performance in the identification of ship and corner reflector.


Demography, stress, language needs, market demand and workload are just some of the elements contributing to a panoramic view of an association with over 2900 members spread across 99 countries. This


The invention relates to a UV-curable ink or a UV-curing printing ink, in particular for plastic bodies, which comprises or one or more photoinitiators and a main resin, which is dissolved in a monomer. The main resin is a polyester, the free functional carboxyl, hydroxyl and / or acrylate groups, and is preferably linear. This ink is used for printing in a preferred embodiment, without an adhesion promoter.


The water pollution status of Shengzhong Reservoir during 2004~2010 were analyzed and assessed about the parameters such as CODMn,BOD5,TN and TP adopting the methods of single factor assessment,comprehensive pollution index,Nemerow pollution index,fuzzy comprehensive assessment and water quality identification index.The result showed that the method of water quality identification index is the best one for eutrophication assessment of Shengzhong Reservoir.The single factor water quality identification index showed that the dominant pollutants were TN and TP,appearing eutrophication of the water.Water quality in 2008 was the worst and that in 2010 reached to grade Ⅱ of the Standard.During the seven years,Ave(Iwq)=3.393,under the requirement of gradeⅡ,while the comprehensive water quality identification index(Iwq) fluctuated and the general status tended to be better.According to calculation,the increased TN and TP in 2006 mainly sourced from aquaculture,accounting for 55%and 82% of the total,being 1.97~2.32 times of the reasonable capacity of the reservoir.Therefore the cage aquaculture should be strictly controlled.The study achievement provide valuable information and guide for water pollution prevention and water resource management in Shengzhong Reservoir.


Objective:To investigate the expression and significance of AKT2 protein in human pancreatic carcinoma.Methods:Expressions of AKT2 protein were measured by using SABC immunohistochemical staining in specimens of 63 cases of pancreatic carcinoma and 23 cases of benign pancreatic diseases.The relationship between AKT2 expressions and clinicopathological factors in pancreatic carcinoma was also analyzed.Results:The positive expression rate of AKT2(39.7%) in pancreatic carcinoma as significantly higher than that in benign pancreatic diseases(13%),P 0.05.The expression level of AKT2 protein in panatic carcinoma showed an obvious difference in different histological grade,lymph node metastasis,and TNM stage(P 0.05,respectiv-ely).Conclusion:Overexpression of AKT2 is found in pancreatic carcinoma.AKT2 protein may play an important role in the tumorigenesis and tumor progression in pancreatic cancer.


Metal nanoparticles (NPs) stabilized with thiol- (HS-) terminated polymers have applications in medicine, optoelectronics, and catalysis. It is assumed that upon exposure to oxidants or even air, these NPs lose colloidal stability due to the oxidation of the HS- end-group and elimination of polymer ligands from the NP surface, however, this mechanism does not explain unsuccessful recovery of NP stability by adding fresh HS-terminated polymers. Here we propose the oxidation of the surface metal atoms as a mechanism for the oxidative elimination of polymer from the NP surface. Based on this mechanism, we reversed NP aggregation by reducing the oxidized metal surface and re-attaching HS-terminated polymer ligands. This mechanism is general for various metal NPs and different HS-terminated polymers. We show that oxidative elimination and reductive addition reactions can improve the colloidal stability of polymer-capped metal NPs and control their stimuli-responsive self-assembly.


A numerical study of optimal low-thrust limited power trajectories for simple transfer (no rendezvous) between circular coplanar orbits in an inverse-square force field is performed by two different classes of algorithms in optimization of trajectories. This study is carried out by means of a direct method based on gradient techniques and by an indirect method based on the second variation theory. The direct approach of the trajectory optimization problem combines the main positive characteristics of two well-known direct methods in optimization of trajectories: the steepest-descent (first-order gradient) method and a direct second variation (second-order gradient) method. On the other hand, the indirect approach of the trajectory optimization problem involves two different algorithms of the well-known neighboring extremals method. Several radius ratios and transfer durations are considered, and the fuel consumption is taken as the performance criterion. For small-amplitude transfers, the results are compared to the ones provided by a linear analytical theory.


The article describes a quantum improvement in shipboard acoustic doppler current profiler systems data by eliminating gyro heading and ship position errors via a global positioning system.


SUMMARY Multiple sclerosis (MS), an immune-mediated demyelinating condition, is the most common neurological disease affecting young adults in the UK. It has a high psychiatric comorbidity and over half of patients have some degree of cognitive impairment that adds to the burden of disability. This article reviews the psychiatric and cognitive manifestations of MS and their detection and treatment. Recent advances in the treatment of the disease are briefly reviewed and the impact of disease-modifying therapies on psychiatric morbidity and cognitive impairment is discussed. LEARNING OBJECTIVES • Understand the psychiatric morbidity in MS and its biological counterparts• Understand the cognitive impairment and its biological counterparts• Become familiar with the detection and treatment of the psychiatric and cognitive manifestations of MS DECLARATION OF INTEREST None.


Multiresolution Matrix Factorization (MMF) was recently introduced as a method for finding multiscale structure and defining wavelets on graphs/matrices. In this paper we derive pMMF, a parallel algorithm for computing the MMF factorization. Empirically, the running time of pMMF scales linearly in the dimension for sparse matrices. We argue that this makes pMMF a valuable new computational primitive in its own right, and present experiments on using pMMF for two distinct purposes: compressing matrices and preconditioning large sparse linear systems.


Measles vaccination surveillance and investigation activities require an ongoing investment of about US$50 million/year in the US. Given the high degree of transmissibility of measles preventing the reestablishment of indigenous transmission in the US will continue to require maintaining very high immunization levels and effective surveillance. Although global measles eradication is inevitable immunization programs in most developing countries are not sufficiently developed to make this an imminent possibility. Significantly the Expanded Program on Immunization (EPI) has not enunciated a morbidity reduction target for measles nor a goal of measles eradication. Globally measles vaccine coverage of young children is only about 14%. About US$290 million is presently being spent on immunization programs in developing countries 20% of which comes from international donors. An important question is whether there is a point at which it may be preferable to increase annual expenditures for measles in the short-run to support EPI activities in return for an ability to discontinue measles vaccination programs entirely at some undefined future point. As more countries achieve successful control and elimination of measles this question will become increasingly relevant.


In the past two decades there has been a great attention to Lie (super)algebras which are extensions of affine Kac-Moody Lie (super)algebras, in certain typical or axiomatic approaches. These Lie (super)algebras have been mostly studied under variations of the name "extended affine Lie (super)algebras". We show that certain classes of Malcev (super)algebras also can be put in this framework. This in particular allows to provide new examples of Malcev (super)algebras which extend the known Kac-Moody Malcev (super)algebras.


A compilation of resource material includes a child restraint glossary, common mistakes noted in parents' use of restraints, considerations in the selection of an appropriate restraint, and pictures of dynamically tested restraints. Copies of instruction manuals for these restraints are provided, each preceded by a description and practical comments. Special problems with restraints are examined: too short a seat belt, placement of top anchor strap, locking clip for continuous loop lap/shoulder belts, and double threading single harness buckle. Demonstration techniques for infant and child restraints, and educational materials lists (Action for Child Transportation Safety, Physicians for Automotive Safety) and order forms are included.


Application of knowledge management at the company seems to have a fundamental
requirement in this globalization era. Knowledge management is expected to contibute to both
human recources especially in the banking world. This study aims to measure the impact of
knowledge management in the resolution of internal problem in PT Bank Pembangunan Daerah
Sumatera Selatan dan Bangka Belitung. These result indicate that knowledge management affect
the settlement of internal problems, there is significant influence betwen personal knowledge and
technology towards the completion of the internal problems of company and the most dominant
factor influencing the sattlement of internal problems is personal knowledge.


Can communities of emigrants be assimilated? David Coleman of Oxford University examines how the issues have been dealt with in the United Kingdom.


The η cross section and double helicity asymmetry as a function of transverse momentum have been measured at √s = 200 GeV at the PHENIX experiment at RHIC. The cross section data serve as important input to the extraction of η fragmentation functions, which were essentially unknown before. With the availability of fragmentation functions the asymmetry data can be included in future pQCD fits in order to further constrain the polarized parton distribution functions, in particular the helicity-dependent gluon distribution function. In addition, the η to π0 cross section ratio as a function of transverse momentum has been extracted in a single pass over the same data set, thus minimizing systematic uncertainties. The inclusion of these data in future fragmentation function extractions should allow for more precise results for both particle species.


In this paper we firstly present an explicit dynamical equation which satisfies the general principle of relativity under the framework of classical mechanics. In light of this fact, the necessity of Einstein's equivalence principle for the gravity being geometrized should be reexamined. Especially, Einstein's (strong) equivalence principle claims that the inertial force is equivalent to the gravitational force on physical effect. But in fact the new dynamical equation proves that the essence of the inertial force is the real force exerted on the reference object, which can actually be all kinds of forces such as the gravitational force, electromagnetic force and so on. Therefore, in this context we only retain the numerical equality between the inertial mass and gravitational mass and abandon Einstein's (strong) equivalence principle. Consequently, the candidate for the standard clock should be corrected into the mathematical clock which duplicates the real clock equipped by the observer himself. Then an adjusted physical picture for how to convert the gravitational force into a geometric description on space-time is presented. On the other hand, we point out that all cosmological observations are made by the observer at the present time on the earth, instead of any other observers including the comoving observers in the earlier unverse. On this basis, we introduce an extra factor $b(t)$ in $FRW$ cosmological metric to depict the gravitational time dilation effect since the local proper clock may run in a faster and faster rate with the expanding of the universe. In this way, we may obtain a positive value of $\rho+3p$ and avoid the introduction of dark energy in the current universe.


The rapid development of the Internet has produced great impacts on college students' study,life and thinking and so on.The ideological and political education based on Internet takes the Internet as the carrier to carry out ideological and political education for college students.As a new exploration of colleges' ideological and political education based on Internet,E-class has its own features and competitive advantages.The educators of ideological and political education should study students' characteristics,grasp the opportunities and take powerful measures to explore the effective approaches of colleges' ideological and political education taking E-class as the platform.


AbstractThis paper presents our work on the development of a portable road texture depth (RTD) meter in response to the need of such a device for the quality control of road maintenance work in New...


This paper presents a study about bioclimatic characteristics of vernacular earthen building heritage in Sardinia. The main purpose of this study, according to Project VerSus' main aim, was to understand the logic beneath climate control elements in vernacular architecture, and earthen architecture in particular, in order to eventually apply them in contemporary architecture. The research method was a deductive process based on reviewing some reports written by Italian and foreign travelers that visited Sardinia in the 19th and 20th century. The useful information, including vernacular buildings characteristics and occupancy when this heritage was intact, had been analyzed through bioclimatic knowledge. Furthermore, in order to highlight bioclimatic features of vernacular earthen heritage, a comparative analysis with the vernacular stone building heritage, expression of a different climate context, had been done. Interesting elements in order to achieve thermal comfort conditions have emerged, especially regarding the strict relationship between vernacular buildings physical configuration and their inhabitants' occupancy.


The aim of this study is to find out the effect of current ratio, net profit margin, debt to equity ratio, and inflation to the dividend payout ratioin the pharmaceutical and food & beverage sub-sector companies inIndonesia Stock Exchange during the period 2014-2018.This study uses quantitative as a method. The study used secondary data whichobtained from www.idx.co.id. The analysis used in this study are statistics descriptive, classic assumption test, the analysis of the regression risks and the test of the hypothesis, this study used 76 of Pharmaceutical and Food & Beverage Sub-sector Companies listed in Indonesia Stock Exchange in 2014-2018. Results of the analysis showed that the variable current ratio and net profit margin are positive and not significant impact to the dividend payout ratio, while the variable debt to equity ratio and inflation are negative and significant impact to the dividend payout ratio.

Keywords: Current Ratio, Net Profit Margin, Debt To Equity Ratio, Inflasi, Dividend Payout Ratio.


There was frequent warfare in the period of Three Kingdoms. As a result, the rigid education system from the East and West Han dynasties was broken down. In order to gain the upper hand in competition and foster talents by making use of both civil and military resources, all the three kingdoms tried to enhance education and establish their supreme colleges, among which, those established by the Cao Wei kingdom is typical in nature. These supreme colleges were considerably sized and systematic so that they established and secured the position of Jin Wenjing. The local education in the period of Three Kingdoms also enjoyed certain scale and many local officials tried to enhance education and set up schools within their administrative regions. All these helped to inherit and develop traditional Chinese culture. But the education in the period of Three Kingdoms did not fulfill its expectant effect due to the rulers interest, students source and teachers resource. We may therefore draw some lessons from such failure.


Tuban town square are included in one of the utilization of active open space in the Tuban area. The town square is located in the city center and near of the many tourism objects in Tuban. One of them such us Sunan Bonang Funeral. The goals of this study are to verivy the effect of pilgrimages acivity to the public open space of Tuban town square. The Targets to be achieved, such us :1) Identification the effect based on characteristics Type of Activities in the Sunan Bonang Funeral Pilgrimage Area, 2) Identification the effect based on characteristics Type of activity Around the Public Open Space, 3) Analysing the factors that affect the pilgrimage activity to the public open space. 4) Verivy the affectthe pilgrimage activity to the public open space. Hypothesisin this studyare have or have no effect of pilgrimage activitytothe public open space of Tuban town square.So it can be seen the factors that effect of the pilgrimage activity to the public open space, and also presence the effect caused by pilgrimage activity to the public open space of Tuban town square.Keywords: Activity, Pilgrimage area, Public Open Space


The invention discloses a preparation method for health beer, relates to the technical field of health wine, and is characterized in that the preparation method successively comprises the following steps: smashing, gelatinizing, saccharifying, preparing a health auxiliary material, mixing, filtering, boiling, and treating and fermenting in a whirlpool tank. The preparation of the health auxiliary material comprises the following steps: (1) respectively taking 15-30 parts by weight of fructus crataegi, 10-20 parts by weight of chrysanthemum and 5-15 parts by weight of honeysuckle; (2) removing kernels of fructus crataegi of the step (1) and carrying out smashing treatment, and fully stirring with the chrysanthemum and the honeysuckle of the step (1); and (3) adding the mixture obtained by stirring in the step (2) into 40-80 parts by weight of water, then together putting into a pot for boiling, and thus obtaining the health auxiliary material. The produced beer has quite good efficacies of lowering lipid and lowering blood pressure and other health effects, moreover, has relatively pure and normal taste, is suitable for the taste of the majority of ordinary consumers, and is easy to sell.


ABSTRACT The evolution of digital media has inspired new narrative forms within the media context. In the last few years, interactive documentary has presented complex and alternative ways to access information. This article presents an analysis of this statement consisting of the case study of five international productions: Bear 71, A Short History of the Highrise, Pirate Fishing, Do Not Track and Párkinson, que tiemble el camino. The production of interactive documentary in online media as a journalistic format is tackled with a multidimensional approach which incorporates the product, the user's perception and the author's view. The exploration of new formats in online media is linked to innovation and a contemporary response to the audiences, who are now able to interact, play and share in an environment favoured by mobile communication and the skills of the current society.


In market conditions, the production of products with higher value added creates competitive advantages for agricultural producers and grain processing enterprises. Improving the process of value added planning in the grain product subcomplex in this sense is one of the key factors. The purpose of the article is to study the theoretical aspects of the category "value added planning" and the peculiarities of its application in the planning process at the enterprises of the grain products subcomplex of the AIC of Ukraine. The research used dialectical, monographic methods and a systematic approach (to determine the role of value added planning as a systemic and complex phenomenon), as well as statistical methods, analysis and synthesis - to substantiate the calculated data. Gross value added includes the following main elements: wages with accruals; depreciation deductions; profit; rent; interest paid for the use of loan capital. Gross value added is greater than net value added at the cost of consumption in the production of fixed assets (depreciation). Net value added is essentially newly created value in the production process. Value added planning in the grain product subcomplex of the AIC is of great importance to ensure the timeliness of technological operations and the rational use of production resources. In this process, it is important to calculate the planned value of each element of value added, matching their values with the maximum growth of profits. In our opinion, in solving the problem of improving the efficiency of grain production an important role is given to the planning of such an element of added value as wages. This issue needs to be handled in such a way that labor productivity grows faster than wages. Here it is necessary to pay attention to the fact that the involvement in the production of highly qualified employees and their proper motivation, along with an increase in wages, the company will receive more profit. Since rent is an element of value added that is included in the cost of production, its planned growth should be accompanied by a proportional increase in production efficiency. Thus, in the course of our research it became clear that the increase in the value added is one of the main factors increasing the efficiency of production at the enterprises of the grain product subcomplex of the AIC of Ukraine. Therefore, it is very important to consider the process of planning value added comprehensively, looking for reserves to increase it. We define the category of "value added planning" as a systemic and complex phenomenon, where profit planning is the final link in the plans of all the components of added value, which takes into account the optimization of production, as well as the rational ratio of remuneration to employees and owners of the enterprise.


The recent re-emphasis of public transport as a necessarily increasing component in mobility and accessibility within towns and cities is calling for much innovation in the field of funding. The high emphasis on the social nature of public transport in most European countries and, in others, established mechanisms of investment appraisal which are more suited to road construction evaluation, have combined to induce significant differences and no little degree of innovation in public transport funding. This paper assembles the range and nature of both investment and operating subsidy funding throughout Western Europe. Public and private sector sources are described, along with the rationale and justification used. Although largely indicative, the extent of "gains" and "losses" to the various relevant agencies, including the funding agency, are outlined. Limitations and controls, where applicable, are also considered. The paper is thus a state of the art review which will show alternative options for funding as currently practised, indicating the scope for further innovation in several countries and the conditions to be satisfied for their fulfilment. The emphasis is placed on bus planning, as railway funding is covered in the 1992 PTRC paper given by Steer,J (see IRRD 859362). For the covering abstract of the seminar see IRRD 859831.


Extended Abstract The control of phosphate (P) in water bodies is an important topic for aquatic environments. Phosphate is discharged into aquatic environments from various point and non-point sources, causing eutrophication when present in excessive amounts, thus posing a great threat to aquatic environments and human health due to harmful algal blooms [1]. The threshold value of total phosphorus (T-P) for eutrophication is reported to be > 0.035 mgP/L [2]. In order to prevent eutrophication in lakes and rivers, phosphate released into water bodies should be properly controlled. Various chemical and biological treatment technologies have been used to reduce the T-P concentration in water and wastewater [3]. Recently, nanotechnology-based water and wastewater treatment methods have attracted a considerable amount of attention in environmental disciplines [4–6]. For phosphate removal from aqueous solutions, nanoparticle-based adsorbents have been synthesized and tested by numerous researchers. Two approaches have been used regarding the use of nanoparticle-based adsorbents for phosphate removal. The first approach is related to directly applying nano-sized particles, whereas the second approach involves the application of nanoparticle-based composite adsorbents. Even though nanoparticles have been reported to have high phosphate adsorption capacity, they may be limited for large scale applications due to agglomeration and separation problems. In addition, nanoparticles may not be suitable for fixed-bed type applications, because they are not granular-type adsorbents and may cause hydraulic problems during wastewater treatment. In order to overcome these problems of nanoparticles, some researchers have prepared nanoparticle-based composites for phosphate removal. In this study, iron oxide nanoparticle-chitosan composites were synthesized for phosphate removal from natural water collected from the Seoho Stream in Suwon, South Korea. Batch tests demonstrated that phosphate removal by the composites was not sensitive to pH changes between pH values of 5.0 and 9.0. During six cycles of adsorption-desorption, the composites could be successfully regenerated with 5 mM NaOH solution and reused for phosphate removal. Column experiments showed that the composites could be successfully used for phosphate removal under dynamic flow conditions. A pilot-scale field experiment was performed in a pilot plant built nearby the Seoho Stream. The natural water was pumped from the Seoho Stream into the pilot plant, passed through the chemical reactor/dissolved air flotation process, and then introduced into the adsorption tower (height = 100 cm, inner diameter = 45 cm, flow rate = 7.05±0.18 L/min) for phosphate removal by the composites (composite volume = 80 L, composite weight = 85.74 kg). During monitoring of the adsorption tower (33 days), the influent total phosphorus (T-P) concentration was in the range of 0.020–0.046 mgP/L, whereas the effluent T-P concentration was in the range of 0.010–0.028 mgP/L. The percent removal of T-P in the adsorption tower was 52.3% with a phosphate removal capacity of 0.059 mgP/g. We demonstrated that the composites could be successfully applied as adsorbents for phosphate removal from natural water.


In the North Sea, hydrocarbon release (HCR) from offshore topside piping that is inherently degrading because of vibration-induced fatigue (VIF) has been a significant challenge. This challenge is further exacerbated when the operating assets are located in Arctic environments, especially because of higher temperature gradients and other operational challenges. The result is a significant increase of VIF failure of topside piping, which causes a higher risk of potential HCR in Arctic environments. The "zero oil spill" requirement in the Arctic region requires operators to follow stringent guidelines to mitigate the risk of VIF failure of topside piping. In this regard, this paper demonstrates the application of the Bayesian network (BN) for risk-based fatigue integrity assessment of the topside piping. The value of the calculated risk depends upon the values of likelihood of failure (LoF) and consequence of failure (CoF). The value of LoF in turn depends upon the measured vibrational velocity (coupled with the vibration assessment criteria of the Energy Institute guidelines) and probabilistically estimated remnant fatigue life (RFL) of topside piping. Likewise, the CoF has been assessed from safety, environmental, and business perspectives. The BNs have been modelled using GeNIe and have been utilized to estimate the risk. The outcome of the fatigue integrity assessment using the proposed approach is the categorization of piping into various risk groupings. Piping in the high-risk category is thereby prioritized for inspection, thus preventing HCR in the fragile Arctic region. An illustrative case study, demonstrating the usability of the proposed approach, is presented.


According to the increasingly serious auto emissions of atmosphere pollution and health hazard problems,analyses the cause of formation of the car emissions,and proposes the corresponding measures to solve the control and has an important practical significance.


Abstract : Mr. Charles Corns, in his speech on Structural Design in the Corps, spoke about the training of structural engineers, the responsibility of Office, Chief of Engineers (OCE), for issuing technical guidance to field offices, and the structural engineering research program. COL Patrick Marks, discussing Computer Support for Engineers, stressed OCE's willingness to help with hardware procurement, software support, research support dissemination efforts, contractual support, and ADP planning. Mr. Corns' second speech, The Role of Computers in Civil Works Design, gave the historical background for using the computer for structural analysis, surveyed the current Civil Works development program for computer use, and discussed some areas where computer analysis has vastly improved structural design. Mr. William D. Ashton, in his speech on Computer-Aided Bridge Design, told how the Rock Island District (RID) has greatly increased its design efficiency and reduced design time and costs by using the computer. Mr. James Cheek in his talk, Engineering Computer Graphics, gave the history of the Wes ADPC computer graphics capability. Dr. N. Radhakrishnan, discussed Some Recent Applications of the Finite Element Method In Corps' Work. Mr. Richard Delyea presented the Federal Construction Council's System called FACTS. A similar library called Conversationally Oriented Real-Time Programming System (CORPS) is maintained by the Corps of Engineers at WES.


tag=1 data=SOG pulls out of Tanami search

tag=2 data=Bell, Stephen

tag=3 data=Australia's Mining Monthly,

tag=6 data=December 1998

tag=7 data=65-67.

tag=8 data=GOLD%LAND%DEVELOPMENT

tag=9 data=NORMANDY MINING LTD%CALLIE%SONS OF GWALIA%OTTER GOLD MINES%TENNANT CREEK

tag=10 data='Fancy a tango in the Tanami? Bring your wallet and make sure its full.'

tag=13 data=V/F


This writing discuss women's body authority in Nengget Ceremony in Karo Land that attacked by the disaster of Sinabung Mountain eruption. The patriarkal construction in the traditional custom and culture as well the religion interpretation has become the tool which has contributed to legalize the woman's oppression in Karo Regency. This writing will discuss how the patriarkal domination in the traditional marriage was built through traditional relation model which legitimated the concept of man absolute ownership over women's property, status, role, and body. This writing will discuss the influence of the relation model of violence in family.


We study magnetic properties of metallic multilayers with FeRh/ferromagnet interfaces grown by low-temperature molecular beam epitaxy. Room-temperature coercivity of the ferromagnetic layers is significantly enhanced after the growth of FeRh, proving the existence of the exchange coupling between the antiferromagnetic FeRh layer and the ferromagnetic layer. However, exchange bias is not clearly observed probably due to the presence of disordered structures, which result from the lattice strain at the FeRh/ferromagnet interfaces due to the lattice mismatch. We infer that the lattice matched interface between FeRh and ferromagnetic layers is a key parameter for controlling magnetic switching fields in such multilayer systems.


Common ground processes [26] can improve performance in communication tasks [72, 42, 43, 24], and understanding these processes will likely benefit human--computer dialogue interfaces. However, there are multiple proposed theories with different implications for interface design. Fusaroli and Tylén [40] achieved a direct comparison by designing two models: one based on alignment theory and the other based on complementarity theory that encapsulated interpersonal synergy and audience design. The current research used these models, extending them to differentiate between interpersonal synergy and audience design. Few studies have tested multiple common ground models against tasks representative of envisioned human--computer interaction (HCI) applications. We report on four such tests, which allowed examination of generalizability of findings. Results supported the complementarity models over the alignment model, and were suggestive of the audience design variant of complementarity, providing guidance for HCI design that differs from contemporary approaches.


Tritryps are protozoan parasites that belong to the Trypanosomatidae family, which encompasses the etiologic agents of leishmaniasis, African and American trypanosomiasis. These parasites undergo different stress conditions across their life cycle, such as nutritional stress, which needs to be deadened in order to guarantee the survival of the parasite inside its vector and mammal hosts. Here we show that the lack of the serine threonine kinase PKB / AKT-like function, either by allosteric inhibition of its Plekstrin domain (PH) in T. cruzi, the reduction of the gene transcripts in T. brucei by RNAi assays, or by AKT-like gene knockout in L. major, reduce the tolerance to nutritional stress of parasites that triggers apoptosis-like events, including DNA fragmentation, mitochondrial damage and loss of plasma membrane integrity. Additionally, we observed that double knockout of Akt-like in L. major impairs its infective capacity. This work confirms some of the previously described functions regarding parasite survival for AKT-like kinases in the Leishmania genus. The present work also provides strong evidence of the probable function of Akt-like in T. cruzi and T. brucei survival and infectivity. Author summary Endemic countries for neglected tropical diseases are called to play a paramount role in the discovery of new drug candidates through the application of new drug development strategies. Rational drug design method have proven to be compatible with the development of new drug for orphan and neglected diseases since it substantially reduces the costs of discovery and development, a desirable condition for public funded initiatives. Previously we have identified a new parasite protein kinase (AKT-like) as promising new target candidate by means of computational tools and probed its biological role in trypanosomatids. Here we show that inhibition of the AKT-like kinase in trypanosomatids by different approaches (chemical inhibition, interference RNA and gene knockout) decreases the fitness and survival of the parasites in vitro, interfering with the capacity of the parasites to react and survive stress conditions similar to those experienced by the cell in the natural life cycle. Additionally our results strongly supports the potential of a new family of compounds previously described by bioinformatics means as potential trypanocidal agents. Altogether we show that the specific inhibition of the AKT-like is a promising strategy for the further development of anti-trypanosome drugs.


Abstract : Nineteen rubber compounds were tested in T142 tank tracks pads at the Yuma Proving Ground (TECOM Test 1-VC-087-142-027). The wear data were analyzed with the objective of selecting some of these compounds for use in a projected study of the correlation between field wear and wear on a test machine which is currently being constructed. Recommendations are made based on these data. Some of the worn pads were sent to MTL and were examined visually and photographed. An abrasion pattern (i.e., a series of parallel ridges) was found on most of the pads which had been worn on the paved road course. Some of these patterns were examined in more detail by microscopy and profilometry. Some of the pads worn on the paved road developed long horizontal slits or pockets. On the hilly cross- country and combination courses, failure was primarily by chunking, though some pattern abrasion was also detected in a few pads. Keywords: Elastomers, Tanks (tracked vehicles), Wear, Abrasion resistance, Field tests.


In the early stage of the vehicle development, the analysis and test of the K&C (Kinematic & Compliance) characteristics are very important because we are able to expect the R&H performances through their parameters. They are measured by SPMD (Suspension Parameter Measurement Device) and usually simulated by ADAMS. Nowadays it is required to get more accurate solutions of the K&C characteristics. So in this paper we study on the modeling methods for K&C analysis. It starts by using flexible model of the suspension parts like knuckle.


We compare optical parameters of Ge2As(Sb)2Se(Te)x (x = 5, 7) glassy films. Optical gap obtained from transmission and reflection measurements decreases in the sequence Ge–As–Se → Ge–Sb–Se → Ge–As–Te → Ge–Sb–Te similarly to decreasing glass-forming ability of bulk systems. We have found from spectroscopic ellipsometry measurements that spectral dependence of imaginary part of the dielectric function shifts to lower energies in the same sequence. This indicates to strong correlation between structural arrangement of atoms in these ternaries and their electronic properties. Ge2Sb2Se5 crystallizes upon thermal annealing with accompanying change in reflectivity. No change in the structure of Ge2As2Se5 is found after annealing.


ABSTRACT:
The current standard of care medical model is a disease-based approach, focused on achieving a specific diagnosis and applying a monotherapy to the labeled condition. Chronic fatigue syndrome (CFS), not dissimilar to other complex syndromes may require a different viewpoint to improve patient outcomes.  This model that would be adequately suited for complex conditions must intervene at multiple levels to address core clinical imbalances.  In these syndromes, diagnosis and determination of appropriate treatment options is a complex process that requires a move toward a more patient-centric model of care.  One that includes elucidation of potential causes, such an ongoing environmental exposures, involves patient participation and provides individualized care. The functional medicine model is uniquely suited to more fully evaluate and understand underlying factors in multifaceted syndromes such as CFS.  Functional medicine practitioners spend time with their patients, listening to their histories and looking at the interactions among genetic, environmental, and lifestyle factors that can influence long-term health and disease progression.  This model goes beyond the diagnosis, and focuses on an understanding of the distinct mechanisms including predisposing genetic factors, unique environmental susceptibilities and underlying dysfunctions in order to determine and avoid hazardous toxic exposures and/or lifestyles, prescribe appropriate evidence based therapies all aimed to improve overall health and function over time.
Objectives: The purpose of this case study is to describe the potential benefits of a functional medicine approach, emphasizing genetic uniqueness and environmental exposures, in the development, progression and treatment of CFS.
Methods: A patient diagnosed with CFS was assessed using the functional medical model, with a focus on environmental exposures and genetic SNP profiles.  Personalized care was provided, including education on environmental hazards and treatment.  Outcome measures were obtained pre- and post-treatment. These measures included validated surveys (Medical Symptoms Questionnaire, Revised Fibromyalgia Impact Questionnaire and Chronic Fatigue-Fibromyalgia Questionnaire) and objective markers such as blood and salivary biomarkers of health and function.
Results: The patients had clinically significant reduction in fatigue, improved health and function as documented with both subjective and objective outcome measures, up to as much as 12 months after treatment initiation. Although some mild side effects were reported, no serious adverse effects occurred.
Conclusion: This unique case study suggests the functional medicine model with emphasis on environment-genetic interactions may be of benefit in the assessment and management of patients with complex syndromes such as CFS. Further investigations with larger studies, including randomized controlled trials, in a more specific CFS population (with known toxic hazardous exposures) may be warranted.


In this paper, we shall prove the existence of a t-conformal measure supported on conical points for a rational map T whose critical points in its Julia set are recurrent. In particular, there always exists a /-conformal measure supported on conical points for the polynomial T(z) = z d + c.


Electromyography(EMG) signals provide significant information for the diagnosis of neuromuscular disorders like Amyotrophic Lateral Sclerosis(ALS) which is a form of Motor Neuron Disease(MND). Due to the stochastic nature of EMG signals different preprocessing and feature extraction techniques need to be applied in order to extract useful information from the raw noisy signals. Time-Frequency analysis and EMG Decomposition are two of the widely implemented techniques for feature extraction from EMG signals. However, due to extrinsic and intrinsic artifacts any one feature extraction technique alone does not provide enough information in order to show a consistent performance of classification across a variety of dataset. EMG signal data set acquired from different sources provide varying outcome when passed through the same classification technique. This is a major problem while creating software which is able to perform automated classification and analysis of EMG signals on a wide variety of data set with minimum human intervention. This paper proposes a method for classification of ALS based on evaluation of multiple features extracted from three domains of EMG signal: time domain representation, frequency domain representation and Muscle Unit Action Potential(MUAP) waveform acquired via EMG decomposition of the signal. 43 features were evaluated using feature selection techniques like chi-squared test and recursive feature elimination. Our experimental results show that amplitude, duration and area of the MUAP waveform estimated for each motor unit, inter-spike-intervals of the motor units, variance, zero crossings, zero lag of autocorrelation, waveform length and slope sign change of the time domain representation, average spectral amplitude, total power, variance of central and mean frequency from feature domain representation of the signal provides the best accuracy at an average rate of 85%, a true positive rate(TPR) of 86% and a false positive rate(FPR) of 20% approximately.


A motor vehicle functional component (14), in particular motor vehicle engine compartment functional component (14), such as engine block component (12), suction tube member housing component, in particular pump housing component, the filter housing component and the like, at one of the component (14) facing away outer side (16), with a thermally insulating and / or sound emission insulating member (18). According to the invention it is provided that the insulation member (18) is adhesively by an adhesive foam (36) with the outer side (16) firmly connected.


QA architecture The QA architecture is based on the Episodic Transformer architecture [6] depicted in Figure 1. Using multimodal transformers, the QA can direct its attention over certain observations in the trajectory about the words used for the question and the previously taken action. Thus we can train the QA over the full trajectory and use it on partial trajectories (up to time step t) at test time.


In infancy when malnutrition can cause impaired the development of the physically, mental, social, and intellectual nature of the settled and continue to be taken until the child becomes adult. The aim of this research was to know the pattern of give Complementary Feeding and growth in infants age 6-8 months in Puskesmas Simalingkar Medan region working area. Types of this research was descriptive by cross sectional design. The samples were 61 baby by total sampling methode. The primary data were obtained through interviews using food recall 24-hour and questionnaire. The result showed that an average of give Complementary Feeding has been done well, types and forms of food given to infancy age 6-8 months, which was crushed food milk or porridge and porridge filter was 41,0%, ordinary soft or food porridge and team rice was 44,2% and solid food or family meal was 14,8%. The baby growth based on weight for age (W/A) the category  normal 52,6% the category is very low 19,7%. The baby growth based on lenght for age (L/A) the category normal 37,7%, category of very sort 8,2%, the baby weight for length (W/L) category normal 47,5%, the category of very thin 8,2 %. The baby's growth based index antropometry (W/A), (L/A), and (W/L) in this research by the outline in normal category even though the pattern of given Complementary Feeding there is still not approriate. Key Word : Complementary feeding, growth, baby age 6-8 month


---------------------------------------------------------------------***--------------------------------------------------------------------Abstract Multiplication of complex number finds numerous applications in Science and Engineering. Complex multiplication design can be the most time and area consuming operations in DSP. Hence, an attempt is made in this paper to reduce the complexity of complex multiplier by using Vedic mathematical techniques. Vedic mathematics contains 16 sutras which are mathematical short hands for range of operation covering basic arithmetic's, algebraic and trigonometric operation to more complex calculus operation. Out of 16 sutras two sutras are used for multiplication. Traditionally, the complex multiplier suffer from low speed due to more number of partial product and carry propagation. A complex multiplier is designed using Urdhva Tiryagbhyam sutra. The results prove that the proposed vedic multiplier is faster than the conventional multiplier. A 8 point radix 2 Decimation in Frequency(DIF) Fast Fourier Transform(FFT) algorithm is implemented using the proposed vedic multiplier .


Nearly 11 years and hundreds of research reports later, the betting situation remains relatively unchanged—although we can tell the bettor that his chances are a little greater in England than in Scandinavia, a refinement we could not have offered 11 years ago. Meehl's little puzzle, which must seem positively perverse to the examined graduate students, underscores the current status of research into the etiology of schizophrenia. Researchers from the opposing "biologic-geneticist" and "environmentalist" schools agree on one set of findings: Schizophrenia is more common in identical twins than fraternal twins and is more common in firstand second-degree relatives of schizophrenics than in the general population. But although agreed on these findings, the geneticists and environmentalists are in sharp disagreement about the major causes or mechan-


More than 100 intelligent vehicle highway system (IVHS) navigation systems are being built worldwide. Japan and the United States are the leaders in developing systems, with the second grouping of countries being Germany, the United Kingdom and Canada. Various positioning technologies such as the Global Positioning System (GPS), the Radio Determination Satellite System RDSS, dead reckoning, signposts, map matching, and terrestrial RF systems are used more in some countries than in others, and these trends are reported. Countries in some regional blocks use certain positioning technologies more prominently than those used in other blocks. Examples of novel systems in the four basic categories (autonomous, fleet management, advisory, and inventory) are given to illustrate the trend toward specific market penetration and thus the diversity among systems. A brief description of future trends is given.


During their senior life, some dogs may show progressive changes in their normal behavior such as disorientation, decreased interaction with family members, ...


The paper studies proverbs and sayings, which reflect the opinion of the Russian people on business sphere: the personality and typical behavior of a businessman, business affairs, bribery. Regardless of the time period of the material collection, negative evaluation of business sphere prevails in the analyzed proverbs and sayings.


The use of a two-dimensional finite difference simulation technique to determine optimal design parameters for the fabrication of TE/TM-mode converters on


This is a celebration of that most popular of all garden flowers, the rose. 96 colour plates illustrate more than 500 roses of every kind - from four inches high, 40 feet tall, roses in a multitude of subtle colour combinations to even green roses. 800 alphabetically arranged descriptions give details of height, flowering times, scent, the raiser's name and the date of introduction plus guidance and advice for the gardener on all aspects of cultivation - training, pruning, propagation and the control of pests and diseases. Patrick Synge is the co-author of "The Dictionary of Garden Plants in Colour" and edited the journal of the RHS for many years.


Aim To construct and validate the in vitro cell-based models for the purpose of screening and investigating small molecules targeting PDGFR-β.Methods Plasmid containing the human PDGFR-β gene was constructed and stably transfected into the mouse NIH 3T3 cells,followed by the functional analysis of the transfected clone cells.HeLa cells were transiently transfected with the exogenous PDGFR-β,and the PDGF-dependent tyrosine phosphorylation was examined.Results Clone cells with stable transfection of PDGFR-β retained the PDGF-dependent growth in the absence of serum in culture medium.HeLa cells transiently transfected with PDGFR-β showed the PDGF-dependent tyrosine phosphorylation.Validation of the mechanism-based cell models above was carried out by the application of known PDGFR-β inhibitors as well as small molecules synthesized in the lab.Conclusion The cell models demonstrated high specificity and sensitivity in terms of PDGF-PDGFR-β pathway,which would serve as mechanism-based cell models for screening small molecules targeting PDGFR-β and other RTKs.


The system engineering approach has been taken to describe the technical baseline under which the Solid Waste Program is currently operating. The document contains a mission analysis, function analysis, system definition, documentation requirements, facility and project bases, and uncertainties facing the program.


in the infarcted heart. All that remained, we Introduction assumed, was to find the right dose of cells needed to completely repair the infarct and show functional Much of the morbidity and mortality from myocardial infarction results from the heart's inability improvement. Disillusionment soon followed, however, when quantitative, dose-response studies were to regenerate significant muscle mass in the infarct. Multiple groups, including our own, have studied undertaken. We observed no increase in graft size over an input range of 3 to 25 million cardiothe possibility of regenerating new muscle in infarcts by cellular implantation (cellular cardiomyocytes [9]. (For reference, the adult rat left ventricle contains >20 million cardiomyocytes [10].) myoplasty). It seems intuitive that the most natural approach would be to replace dead cardiomyocytes Furthermore, grafts were all small, never exceeding 2% of the left ventricle at one week after imwith new, living cardiomyocytes. Indeed, initial studies with cardiomyocyte transplantation genplantation. This suggested that graft cell death was limiting the amount of new myocardium formed. erated considerable excitement. Field's group, for example, showed that fetal cardiomyocytes formed Studies using TUNEL analysis showed that, although graft cells appeared viable shortly after stable grafts when implanted into the normal myocardium of mice and dogs, and that the graft implantation, by 24 hours >32% had fragmented DNA. Cell death continued for at least 4 days after cells formed intercalated disks with host myocytes [1–3]. Other groups, including our own, subimplantation, when the TUNEL index was 10%. By 1 week, the TUNEL index was >1%, suggesting sequently showed that fetal or neonatal cardiomyocytes could form stable grafts in infarcted the wave of cell death was largely complete. In the current issue of The Journal, Mulleror cryoinjured hearts [4–8], although the grafts typically were located at the lesion's periphery, close Ehmsen and co-workers have extended these observations using a clever and highly quantitative to host myocardium. molecular technique to measure graft cell number in the heart [11]. The authors implanted neonatal cardiomyocytes from male donors into normal hearts of syngeneic female rats. To quantify graft Facing Up to Death cell number, the authors used TaqMan real time quantitative PCR to detect the Y chromosomeThese qualitative studies painted a rosy picture, where it was possible to create new myocardium linked gene, sry. The ratio of sry to a somatic gene,


Elastic pavements, low-freezing point pavements, and energy exchange pavements meet the function of road ice and snow melting but may damage the pavement performance. To solve the above problems, this study intends to develop a noncontact snow-melting pavement by using induction heating technology. The steel wool asphalt mixture was prepared, and the effects of steel wool on road performances including the high-temperature performance, low-temperature performance, water stability, and fatigue performance were studied. The influence of the asphalt mixture's factors, environmental factors, and human factors on the ice-melting characteristics of steel wool asphalt mixture was analyzed. A prediction model of the ice-melting rate of steel wool asphalt mixture based on a double-hidden layer backpropagation (BP) neural network was established. The results show that the road performance of the asphalt mixture mixed with steel wool mostly meets the requirements of the specification. The increase in steel wool content and length can improve the road performance to a certain extent. In terms of ice-melting performance, the content and length of steel wool have a beneficial effect on the ice-melting rate. The lower the ambient temperature or the thicker the ice layer, the slower the ice-melting rate. The greater the heating intensity, the faster the ice-melting rate. The average absolute error of the melting ice prediction model is 0.016, so the melting ice effect can be well predicted by this model.


Previous studies have proposed that gestures in a second language (L2) play a role in revealing speakers' thinking-for-speaking (TFS) patterns of each language speaker. Languages are categorized as satellite-framed language (e.g., English) or verb-framed language (e.g., Korean) according to how path and manner of motion events are encoded. The main purpose of this study is to examine TFS patterns of advanced Korean ESL speakers embedded in L2 speech and gesture of path and manner of motion events. Findings suggest that by synchronizing path gestures with verbs and manner gestures with gestural expressions without verbal descriptions, advanced Korean ESL students still maintain their first language (L1) TFS patterns. Thus, it seems to be challenging for L2 speakers, even for advanced speakers, to acquire L2 conceptual knowledge.


Cypoviruses (CPVs) are members of the family Reoviridae that infect insect larvae producing polyhedra in the cytoplasm of mid-gut epithelial cells [1, 2]. Polyhedra are remarkably stable protein crystals and function to protect the virus particles within the crystals from hostile environmental conditions. The polyhedron protein, which is called polyhedrin, is encoded by the virus genome. Recently we have determined the atomic structure of Bombyx mori CPV polyhedra using.a synchrotron microbeam to collect X-ray diffraction data [3]. Polyhedra are made from trimeric building blocks of the polyhedrin interlocked into a tight scaffold generated by the aminoterminal alpha-helix. BmCPV are known to be composed of five viral capsid proteins (VP1-5). We have previously demonstrated that the N-terminal 75 amino acids of VP3 can function as a polyhedrin recognition signal leading to the incorporation of foreign proteins into polyhedral [4, 5]. We also showed that the polyhedrin H1 helix can also function as a polyhedrin recognition signal [6]. I introduce a unique protein expression system in which the expressed target proteins are immobilized into the polyhedra.


High-spin states (I < or approx. 50(Planck constant/2pi)) of the odd-odd nucleus {sup 170}Ta have been investigated with the {sup 124}Sn({sup 51}V,5n) reaction. The resolving power of Gammasphere has allowed for the observation of eleven rotational bands (eight of which are new) and over 430 transitions (approx350 of which are new) in this nucleus. Many interband transitions have been observed such that the relative spins and excitation energies of the 11 bands have been established. This is an unusual circumstance in an odd-odd study. Configurations have been assigned to most of these bands based upon features such as alignment properties, band crossings, B(M1)/B(E2) ratios, and the additivity of Routhians. A systematic study of the frequency at which normal signature ordering occurs in the pih{sub 9/2}nui{sub 13/2} band has been performed and it is found that its trend is opposite to that observed in the pih{sub 11/2}nui{sub 13/2} bands. A possible interpretation of these trends is discussed based on a proton-neutron interaction.


Firms, and other agencies, tend to adopt widely used software to gain economic benefits of scale, which can lead to a software monoculture. This can, in turn, involve the risk of correlated computer systems failure as all systems on the network are exposed to the same software-based vulnerabilities. Software diversity has been introduced as a strategy for disrupting such a monoculture and ultimately decreasing the risk of correlated failure. Nevertheless, common vulnerabilities can be shared by different software products. We thus expand software diversity research here and consider shared vulnerabilities between different software alternatives. We develop a combinatorial optimization model of software diversity on a network in an effort to identify the optimal software distribution that best improves network security. We also develop a simulation model of virus propagation based on the susceptible-infected-susceptible model. This model allows calculation of the epidemic threshold, a measure of network re...


Selenium (Se) is an essential micronutrient with a range of physiological and antioxidative properties. Reports regarding effect of Se application on plants growth and development are not consistent. The identification of effective Se dose and application method is crucial for better understanding of Se translocation within crop plants under drought stress. The present study aimed at investigating the role of Se supplementation in improving the drought tolerance potential of wheat at early growth stages. Two wheat genotypes (Kohistan-97 and Pasban-90) were grown in plastic pots (8 × 12 cm) in green/wire-house experiments. Results demonstrated that the growth and biomass of seedlings increased at high Se foliar concentrations and decreased at low and high Se fertigation levels. The seedlings exhibited the highest values for plant height stress tolerance index (PHSI), root length stress tolerance index (RLSI), dry matter stress tolerance index (DMSI), and fresh matter stress tolerance indices (FMSI) at Se fertigation level of 7.35 μM, whereas Se foliar treatment of 7.06 μM resulted in maximum values for these indices. The seedlings foliarly sprayed with Se maintained higher DMSI and FMSI than those fertigated with Se which suggests that Se foliar spray is more effective than Se fertigation for improving drought tolerance.


Objective To explore how to improve the diagnosis and treatment of Dieulafoy's disease. Methods Six cases of Dieulafoy's were analyzed retrospectively. Among the 6 cases receiving endoscopy examination preoperatively, 4 were subjected to the examination during bleeding. All cases were subject to sewing memostasis. Results Four cases were diagnosed before operation. Five cases cured and 1 died of acute renal failure after operation. Conclusions Emergency endoscopy is the optimal method for diagnosis and sewing hemostasis is a better treatment.


(FH) is rare with a frequency of 1 in 1,000,000.' It is caused hy absence of LDL receptor activity. Cutaneous features and corneal arcus are commonly seen before the age of 20. Polyarthritis may occur in adolescence and premature coronary heart disease with aortic atheroma is usual within the second decade. Our patient is unusual in having survived to the age of 30 and in his very late presentation and spectacular cutaneous manifestations. Despite absent LDL receptor activity, there was a 30% reduction in serum cholesterol levels with the drug regimen, suggesting that the drug-stimulated clearance of plasma LDL was mediated by activation of nonreceptor pathways. LDL apheresis-^ and liver transplantation^ have heen used in this disease.


David Hornbrook's articles in NTQ4 and 5 offered a challenging perspective to the history of drama in education, a critique of present practice and practitioners, and some positive proposals for the future place of the subject in the curriculum. These have provoked widespread interest, and we are now publishing a first selection of comments from fellow drama in education workers, and offering a welcome to further contributions in subsequent issues. These initial responses are from David Morton, adviser to the Leeds City Council's Department of Education; Jon Nixon, a research fellow in the Department of Education at the University of Sheffield; and Tony Graham. Head of Drama at Haverstock School, in the Inner London Education Authority's area.


Abstract Based on students' reflections and testimonials, we examined what it takes to help students become engaged in an online course designed with educators and education researchers in mind. The purpose of this paper is to provide the readers with insights into creating an online learning environment where students succeed by taking active roles and responsibility for their own learning process.


This case series should help first-time teachers anticipate situations they are sure to encounter in the classroom. In this case, Jack Narsen's uneasiness is compounded by his students' focusing on grades, and one student's outspoken criticisms unnerve him. See also the A case (UVA-PHA-0026).


Ground-state phase diagrams for electron-doped high-temperature superconductor-Nd2-xCexCuO4 were investigated based on Gutzwiller mean-field approximation within the t-t′-t″-J-U model.Within a large-U limit,our results show that the antiferromagnetic(AF) order parameter exists until optimal doping.With decreasing U,AF order shrinks rapidly,and d-wave superconductivity(dSC) order parameter is dramatically suppressed.These results are qualitatively consistent with numerical results.


In this article, we report the mechanical and biocompatibility properties of injection-molded high-density polyethylene (HDPE) composites reinforced with 40 wt % ceramic filler [hydroxyapatite (HA) and/or Al2O3] and 2 wt % titanate as a coupling agent. The mechanical property measurements revealed that a combination of a maximum tensile strength of 18.7 MPa and a maximum tensile modulus of about 855 MPa could be achieved with the injection-molded HDPE–20 wt % HA–20 wt % Al2O3 composites. For the same composite composition, the maximum compression strength was determined to be 71.6 MPa and the compression modulus was about 660 MPa. The fractrography study revealed the uniform distribution of ceramic fillers in the semicrystalline HDPE matrix. The cytocompatibility study with osteoblast-like SaOS2 cells confirmed extensive cell adhesion and proliferation on the injection-molded HDPE–20 wt % HA–20 wt % Al2O3 composites. The cell viability analysis with the 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay revealed a statistically significant difference between the injection-molded HDPE–20 wt % HA–20 wt % Al2O3 composites and sintered HA for various culture durations of upto 7 days. The difference in cytocompatibility properties among the biocomposites is explained in terms of the difference in the protein absorption behavior. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012


The duodenal leiomyosarcoma is a rare tumor. Its location in the
duodenum makes diagnosis difficult and often delayed. Surgical treatment is not
consensual because it must take into account anatomical imperatives which vary
depending on the duodenal portion and oncological requirements that are not
currently well known especially with regard to the utility of lymphadenectomy.
We report 2 cases of leiomyosarcomas located at the angle of Treitz. This
location is exceptional and only few cases were reported in the literature.
From these 2 new cases and a review of the literature, we analyze the
clinical features, diagnosis and treatment of duodenal leiomyosarcoma.


The invention relates to the use of an ion-exchange chromatography substrate including a resin of the large-pore vinylic polymer type including DEAE groups and a buffer including trisodic citrate, sodium chloride, calcium chloride, glycine and lysine for reducing the amount of ADAMTS13 present in a solution derived from plasma containing a human von Willebrand factor.


This paper describes the minimally redundant sets of diagonal braces in a grid of cubes in space. A graphical language is developed to describe those sets efficiently. The methods employed are combinatorial; they extend those of Bolker and Crapo's Bracing Rectangular Frameworks. I (SIAM J. Appl. Math. 36 (1979), pp. 473–490).


Introduction: General aviation largely comprises fixed-wing piston-engine light aircraft ( , 12,500 lbs). Unfortunately, this civil aviation sector suffers a vastly inferior safety record when compared with air carriers (60- to 80-fold higher accident rate). Additionally, such mishaps pose a considerable financial burden to both the affected family and the United States: US$1.64–4.64 billion annually. We hypothesize that this safety disparity partly reflects more stringent operational regulations for air carriers. Herein, we determined whether compliance with six selected air carrier regulations could potentially reduce general aviation accidents in degraded visibility (IMC) the majority of which are fatal. Methods: Accidents (2005–2019) were identified from the National Transportation Safety Board Access database. Fleet data for rate calculations were per the general aviation survey and the Bureau of Transportation Statistics. Statistics used Poisson distributions. Results: Of 219 general aviation accidents in IMC, 43 (20%) could potentially have been averted had one, or more, of the selected air carrier regulations been complied with. The largest percentage (62%) of the 43 mishaps were due to pilots operating contrary to the air carrier regulation specifying takeoff or landing weather minimums. The second largest group related to more conservative weather minimums required for an inexperienced airline pilot-in-command, eschewed in 19% of preventable general aviation IMC mishaps. Conclusions: Alignment with the aforementioned air carrier operational rules could potentially blunt the IMC accident rate (by 20%) for general aviation. Practical Applications: Adherence to the aforementioned air carrier regulations should be advocated to general aviation pilots operating in IMC.


From a broad perspective,according to the conditions of horizontal bearing capacity calculation of pile group in the principles,integrating with an engineering example,this thesis puts forwards a calculation formula of horizontal bearing capacity of pile group through analyzing calculation method of the single pile bearing capacity.Accordingly,it may guide horizontal bearing capacity of pile group in actual works.


Tectonic modelling is a very wide area of application over a large range of time scale and length scale. What mainly characterize this modelling field is the coexistence of brittle fractures which relates to the field of fracture mechanics and plastic to viscous shear zones which belongs to the two main branch of continuum mechanics (solid and fluid respectively).

This type of problems arises sometimes in engineering but material do not change their behavior with loading rate or with time or with temperature, and rarely are engineers interested in modelling large displacement in post failure stage.  As a result, tectonicists cannot use commercial packages to simulate their problems and need to develop methodologies specific to their field.

Historically, the first tectonics models made use of simple analogue materials and corresponded more to modelism than actual analogue models. While the imaging of the models, and the characterization of the analogue materials have made a lot of progress in the last 15 years, up to recently, most analogue models still relied on sand and silicone putty to represent the brittle and viscous counter part of tectonic plates.

Since the late 80’s, but mostly during the years 2000, numerical modelling has exploded on the market, as contrarily to analogue modelling, it was easier to capture the thermal dependence of frictional-viscous transition, I use frictional here because most models in tectonics use continuum mechanics approach and in fine do not include brittle material s.s. but rather frictional shear bands. Some groups run these types of simulation routinely in 3D today but this performance has been made at the cost of a major simplification in the rheology: the disappearance of elasticity and compressibility which was present in late 90’s early 2000 simulations and is still very costly because the treatment of “brittle” rheology seriously amped code performances.

Until recently, in both analogue and numerical modelling, I have some kind of feeling that we have been running the same routine experiments over and over again with better performance, or better acquisition.

We are now entering a new exciting era in tectonic modelling both from experimental and numerical side: a ) emergence of complex analogue material or rheological laws that efforts in upscaling from micro-mechanical process observed on the field to plate boundary scale, or from earthquake cycle to plate tectonics, b) emergence of new interesting set up’s in terms of boundary conditions in 3D, c) development of robust numerical technics for brittle behavior d) development of new applications to make our field more predictive that will enlarge the community of end-users of the modelling results

I will review these novelties with some of the work develop with colleagues and students but also with examples from the literature and try to quickly draw a picture of where we are at and where we go.


Psoriasis is a chronic inflammatory disease and topical corticosteroids remain the mainstay of its treatment. Corticophobia, also called topical corticosteroid concerns (TCC), can cause poor adherence to treatment and impact disease control. It is defined as exaggerated fears, anxiety, doubts or reluctance regarding corticosteroid use.1 TCC has been evaluated by a numerical (NS) and a visual analog scale (VAS)2,3 , however, it´s complexity makes an assessment by binary (yes/no) questions too simplistic.


A method of extraction of natural products has been developed. Compared with existing methods, the new technique is rapid, more efficient and consumes less solvent. Extraction of alkaloids from natural products such as Hyoscyamus muticus, Datura stramonium and Ruta graveolens consists of the use of a sonicated solution containing a surfactant as extracting agent. The alkaloids are precipitated by Mayer reagent, dissolved in an alkaline solution, and then extracted with chloroform. This article compares the results obtained with other methods showing clearly the advantages of the new method.


This volume in the American Religious Experience series chronicles the history and present situation of the Catholic Church and the American Catholic subculture in the United States. Catholics have had a long history in America, and they have often had conflicting demands-should they remain loyal to the authority of the pope in Rome, or should they become more accommodating to American culture and society? The Catholic Experience in America combines historical, sociological, philosophical, and theological and religious scholarship to provide the reader with an overview of the general trends of American Catholic history, without over-simplifying the complex nature of that history. The Catholic Experience in America examines many different aspects of what it's like to be a Catholic in United States today, including: the diversity of Catholicism within the Church, including the issues of race, ethnicity, and gender; major turning points in American Catholic history, and how they have affected the everyday experience of American Catholics, such as immigration and nativism, the separation of church and state, and the election of John Kennedy as president; how the Church has handled such contemporary issues as homosexuality, birth control and abortion, and religious education; and the rise and fall of a Catholic subculture capable of providing a Catholic religious identity in America. The volume includes several appendices to further the readers understanding of the Catholic experience in America, including brief discussions of key documents and Church organizations, a glossary of terms, and basic demographic and statistical information.


The machine learning technology has been implemented in control systems successfully especially in the stochastic process. Among the machine learning algorithms, the reinforcement learning algorithm is fairly significant. On the other hand, the elevator, as a facility in daily life, is implemented with several heuristic control methods in the past practice. Simultaneously, the elevator working procedure can be viewed as a stochastic process, so this paper tries to discuss the implementation of several reinforcement learning algorithms on the elevator control system. Through the application of the reinforcement learning algorithms, the elevator system can perform better.


This report discusses the following topics: magnet - voltage dividers temperature & voltage influence error calculation; magnet filters summarized data table; magnet transfer function measurement setup and connection diagrams; response of existing magnet system including ripple reduction filters - Dec 1991; magnet filters - mutual inductance problem; and damping the magnet filters.


A process for the assembly of locking ring bolt (10) with a locking ring (18) and at the height of the closure ring disposed locking rings (16), wherein the locking ring bolt (10) is screwed with only a very low torque in an internal thread of a first workpiece, while one or is more further workpieces to be joined between the first workpiece and the locking ring (18) of the locking ring bolt (10) are located, and the locking ring bolt (10) is set by material of the bush (18) flows into the closed grooves (16) during the closing ring is ( 18) extended at the same time necessarily, whereby a biasing force between the locking ring (18) and the first workpiece is created, and locking ring bolt (10) for performing this method.


It has been frequently said that "Quantum Mechanics is Magic". !e real fact is just the opposite: quantum mechanics is not magic, it is rather one of the best scienti"c theories in terms of the amplitude and exactness of its predictions. Quantum Mechanics surprises us as it does not satisfy some a priori principles usually considered to be necessary preconditions to build up physics (as Einstein dixit). As these principles are also the basis of some important philosophical theories of science, these philosophical theories cannot be well founded. After criticizing them, we other the preliminary lines of a methodology of physics adapted to the formalism of quantum mechanics.


The present study was aimed to examine the cognitive functions among adolescents with online game addiction behaviour. For the present study 60 adolescents who play online games were been studied living in Delhi-Ncr region following cross-sectional research design. The instruments used encompassed of a demographic data sheet, Game addiction scale, Stroop color word test, Trail making test, Eysenck's series of digit span test and n-beck test. The obtained data was been analysed by using SPSS to see the relationship between cognitive functions and game addiction with Pearson-r, frequency distribution and correlation. The findings indicated that gamers who remained preoccupied with playing had difficulty in color naming and indicates withdrawal feature that interfere in their retrieval. And also indicates that online gamers who experienced conflict due to online gaming had significantly deficit in attention and concentration.


American participation in World Fairs in the second half of the XIXth century reflects the growing interest of this nation for foreign trade and peaceful relations with foreign countries. In 1900, their performance at the Paris International Exhibition was better and more impressive than ever before. Their Pavillion on the Quai d'Orsay was a « home » for Americans visiting Paris and the « Expo ». They had exhibits and received awards in all groups but one. Yet, the French did not really perceive the gigantic progress and rising economic power of the United States.


higher (1.4–2 times) as compared to rural and moun-tainous population, while for esophageal carcinoma, on the contrary, the prevalence is higher in the mountain part (almost double) both for the town and country populaiton. Conclusions . Establishment of epidemiologic and morphological features of malignant tumors gives clinicians a chance to take effective measures for early diagnos-tics and effective treatment, whereas healthcare admin-istration may develop prophylactic actions.


The heavy-ion, fusion-evaporation reaction 12 C( 16 O,n) was used to identify γ-decay transitions from excited states in 27 Si above the proton threshold. The precise level energy measurements, J π assignments, and lifetime measurements of astrophysically important 26 Al m + p resonances have allowed an evaluation of the 26 Al m (p,γ) 27 Si reaction rate. An l p = 0 resonance has been newly identified at a center-of-mass energy in the 26 Al m + p system of 146.3(3) keV and is expected to dominate the rate for low stellar temperatures. In addition, an lp = 1 resonance has been identified at 378.3(30) keV and is likely to dominate the rate at high astrophysical temperatures, such as those found in oxygen-neon novae and core-collapse supernovae.


The number of spermatophores inseminated in the bursa copulatrix of females of 21 species of Theclini butterflies varied from 0 to 38, a maximum much larger than reported so far. The variation of spermatophore number observed was analyzed on a phylogenetic tree recently determined, together with variation of wing colors and male mating tactics. Monandrous species tended to be sexually dimorphic in wing color and associated with male territoriality.


This paper presents a model which predicts the temporal response of capacitive humidity sensors made of parallel electrodes and a polymer sensitive coating. This model is used for the simulation of the response of the sensor subjected to specific conditions. The model includes electrostatic and molecular diffusion calculation. As an application example, the model is used to simulate the response of several humidity sensor structures exposed to the conditions of a medical application related to breath analysis. The model may also be helpful to predict the effects of fabrication process uncertainties. Because the model used to describe water diffusion in Polyimide is based on Henry's law and Fick's law, it could be extended to the optimization of capacitive sensors for other vapours


This article focuses on ways that human rights advocates can ensure that trade and trade rules promote rather than undermine human rights. The article concludes that an effective way to achieve respect for human rights in international trade policy is through engaging with trade policy-makers of national governments, and show the positive role a human rights contribution can play in ensuring a fair and democratic international trading system. The article points out that human rights defenders share concerns about trade with development groups, women's rights advocates, environmentalists and others already working on trade, and suggests that human rights advocates demonstrate, through applying the relevant human rights accountability mechanisms, how they can make a positive contribution to making trade more equitable and human rights-friendly. [Original article in English.]


Aim: The purpose of this study was to determine if it was more appropriate assignment of the load of the Wingate test according to the lean body mass in young males. Methods: Wingate tests were performed on a Monark cycle ergometer by using loads of 75, 85, 95 g.kg-1 for the body weight and 90, 100, 110 g.kg-1 for the lean body mass on 24 untrained young males. These loads were applied randomly to the participants. Pedal revolutions for every 5-second were counted during the test and the peak power, the mean power and the fatigue index were calculated. Results: The peak power outputs of the Wingate tests in which 100 and 110 g.kg-1 loads were used for the lean body mass were significantly higher than the peak power outputs obtained from the tests in which 75 g.kg-1 loads were used for the body weight. None of the mean power outputs obtained from the loads was significantly higher than the others. Conclusion: We concluded that assignment of the load of the Wingate test according to the lean body mass would be more appropriate in young males. 100 or 110 g.kg-1 loads for the lean body mass can be used as they result in significantly higher peak power outputs.


The article discusses the complex issue of time and eschatology in the Fourth Gospel. To get a grip on John's eschatology it is necessary to take seriously John's own use of language, and not to let the issue be determined solely by categories or terms (such as 'eschatology' and 'apocalypticism') introduced by scholars. It is essential to understand John's eschatology as an aspect of the Gospel's broader concept of time and the way in which this concept is given linguistic expression. This approach allows more recent, in particular narratological, methods to be applied to determine the Gospel's concept of time. The article addresses the following topics: present and future eschatology in recent scholarship; the fusion of temporal horizons in the Farewell Discourses; motifs of time and eschatology, such as 'the hour', 'the last day', and 'eternal life'; time and narration in John; and implications for John's theology and ethics.


Internet Scavenger Hunt using approved web links listed in this LibGuide. Use the approved web links in this guide to answer the questions


Background  : Untreated acute myeloid leukemia (AML) is universally fatal. In the past few years, there were many cases of AML patients receiving treatment at Surin hospital. Therefore, we have initiated to study the characteristics, treatment and outcome of AML patients in our hospital. Objectives  :  To study the characteristic including age, sex, FAB classification, cytogenetics, complete remission (CR) achievement after the induction course in AML patients. Setting :  Surin hospital Study design  :   Descriptive retrospective study. Method :  A retrospective reviewed of 21 newly diagnosed AML patients receiving treatment at Surin hospital during 1 January 2006 - 31 December 2008. The demographic data, age, sex, FAB classification, cytogenetics, CR achievement after the induction course were analyzed. Results :  Among 21 patients, 10 males (47.6%) and 11 females (53.4%), age ranges between 15-60 years (mean 41.95 years), In cytogenetics groups, patients with favorable, intermediate and unfavorable cytogenetics were 9.5%, 71.4%, and  19.1% respectively. Regarding FAB classification, majority of the patients were M1 (28.5%) follow by M2, M3, M4, MO, M5, M6 and M7 with the percentages of 14.3%, 14.3%, 14.3%, 9.5%, 9.5%, 4.8% and 4.8% respectively. The outcome of the treatment was classified based on CR. The percentages of the patients with CR, not CR and death were 66.6%, 19.0% and 14.3% respectively. Conclusion  :  Complete remission in AML patients in Surin hospital was 66.6% and mortality rate was 14.3%, all patients died of infectious complication after treatment. Strictly infectious control was very important in these patients to decreased mortality rate. Key words  :  Acute Myeloid Leukemia, AML, cytogenetics, complete remission, cytosine arabinoside, anthracycline


Human infections with Lophomonas blattarum are rare. However, the majority of the infections occurred in China, 94.4% (136 cases) of all cases in the world. This infection is difficult to differentiate from other pulmonary infections with similar symptoms. Here we reported a case of L. blattarum infection confirmed by bronchoalveolar lavage fluid smear on the microscopic observations. The patient was a 21-year-old female college student. The previous case which occurred in Chongqing was 20 years ago. We briefly reviewed on this infection reported in the world during the recent 20 years. The epidemiological characteristics, possible diagnostic basis, and treatment of this disease is discussed in order to provide a better understanding of recognition, diagnosis, and treatment of L. blattarum infection.


I, the brain of a paticent with chroiic epidemic enicephalitis of the Parkinsoniani variety, who died of pulmoinary ttubercutlosis, nmutcin-like bodies were found lying in the neuroglial meshes. They possessed no cvtological structure and were niot presenit wN,ithin nieuiroglia or nierve cells. They were present in the white matter of the ccrebellum adjacent to the denitatc inuleluits. They werc spherical in form, with irregutlar edges on high maoniification, aind their diameter varied from 20 to 50 micronis. They were clearly not artefacts anid stainied witlh basic buit not acid dyes. RI. M. S.


AbstractThis paper describes a case history of a deep cement mixed (DCM) column–supported embankment that is part of the Ballina Bypass section of the Pacific Highway Upgrade project in Australia. Measured settlements during and after construction of the embankment were significantly greater than the predicted settlements and suggested that the DCM columns were yielded. The case history was analyzed using a finite-element model based on the coupled theory of nonlinear porous media. Two cases were analyzed: with and without the strain-softening behavior of DCM columns caused by breakage of the soil-cement structure. The computed settlements, excess pore-water pressures, and lateral deformations were compared with field measurements. Results show that there was good agreement between the measured and the computed parameters when the strain-softening behavior of the columns was included. These results clearly show that consideration of the strain softening of DCM columns in the analysis is important if yield...


Abstract Background: The purpose of this study was to describe how patients with persistent pain experience physiotherapist-guided Free Movement Dance (FMD) as a physiotherapy intervention. Methods: Individual interviews were conducted with 20 patients who had participated in FMD for 1–6 semesters with different guiding physiotherapists. The interviews were transcribed and analysed using qualitative content analysis with an inductive approach as described by Graneheim and Lundman. Results: The analysis resulted in one overarching theme—Physiotherapist-guided Free Movement Dance is empowering in everyday living—and five subthemes: Breaking unhealthy patterns generates physical confidence and strength, Developing greater understanding of the body signals, Accepting pain is important but challenging, Taking responsibility for myself and my well-being and Feeling calmer and happier in life. Conclusions: FMD was experienced as a physiotherapy intervention that enabled the patients to develop an awareness of their own movement, and also leading to the feeling of being empowered in everyday living. FMD can be seen to be in concordance with the core values of physiotherapy that individuals have the capacity to change as a result of their responses to physical, psychological, social and environmental factors.


from time the contents of time itself, presumably the history of all shapes of being, and the homage to an external temporality of mediation, which is irre ducible to any form or shape; and (4) the self-transcendence of history occur This content downloaded from 22.214.171.124 on Thu, 29 Sep 2016 04:27:50 UTC All use subject to http://about.jstor.org/terms


745. These assays determine the general toxicity (OECD TG 452 and TG 453) and carcinogenicity (OECD TG 451 and TG 453) of chemicals in laboratory animals after exposure for a period lasting most of the lifespan. Route of administration may be oral, dermal or inhalation, although oral via diet is the most common. OECD TG 453 was revised in September 2009 and replaced OECD TG 451 (older studies may have used OECD TG 451). General toxicity studies usually have a duration of 12 months whilst carcinogenicity studies usually have a duration of 18 or 24 months depending on the species tested. They provide information on major toxic effects, target organ toxicity and carcinogenicity. Although they have not been validated for the detection of endocrine disruptors (EDs), they contain many endpoints that are suitable for the determination of endocrine effects. Organ weights are not always included in the carcinogenicity phases of these studies as neoplastic changes may confound them, but they are generally determined at 12 months. A comparison can be made with validation of the OECD TG 407 (28-Day Oral Toxicity Study) for endocrine endpoints (OECD, 2006) where substances that were moderate and strong EDs for (anti)estrogenicity and (anti)androgenicity (e.g. ethinylestradiol and flutamide) and weak and strong modulators of thyroid hormone-related effects (e.g. propylthiouracil, T4 and methyl testosterone) were detected. Steroidogenesis inhibition was also detected although only one (potent) chemical was used in the validation study (CGS 18320B). OECD TG 453 and TG 452 are likely to be more sensitive than OECD TG 407 because of the extended dosing period and the larger number of animals per group (20 or 50 rodents per sex per group for chronic or carcinogenicity studies respectively compared with 5 in OECD TG 407). OECD TG 453 and TG 452, however, do not contain some sensitive endpoints (e.g. thyroid hormones, estrous cyclicity) that may be included in OECD TG 407.


A 57 year old women with sick sinus syndrome had been implanted with a Biotronik Pikos LP VVI pacemaker. Sinus rhythm was successfully restored by antiarrhythmic drugs three times during the past year. Because of recurrence …


The present invention proposes a filling system for filling a arranged in a submarine reservoir with a granular granulate before, the filling system comprises a pumping member for generating a granule flow towards the reservoir, the filling system includes a separator for extracting a dust fraction from the stream of granules wherein the release member comprises a perforated plate with holes through which the proportion of dust from the granules stream is sucked.


There are few ways in which comparable measures of sexual arousal may be obtained from males and females. Because latency to orgasm is an objective measure that is equivalent for both sexes, it may be a useful dependent variable for the investigation of response patterns and differences in men and women. To explore this possibility 24 men and 18 women participated in experimental sessions during which they masturbated to orgasm while viewing sexually explicit films and then rated the film for its arousal value. Male orgasmic latency was not significantly different across rating categories, whereas female research participants showed a significant quadratic trend in which films perceived as being average in arousal quality resulted in the longest latencies. Possible reasons for this sex difference are discussed, and it is suggested that using latency to orgasm as the dependent variable may be a valuable technique in researching sex differences in response to psychosexual stimulation.