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Natural plant products have served as tremendously valuable tools for deciphering cellular and molecular mechanisms contributing to somatosensation, nociception, and pain. Notable examples include the use of natural analgesics, such as morphine (from the opium poppy) and salicylate (from willow bark) to discover opioid receptors and cyclooxgenases, respectively. Other important examples include the use of natural irritants, such as capsaicin (from chili peppers) and menthol (from mint leaves) to identify ion channels that detect heat and cold, respectively. Indeed, each of these proteins represents a validated or potential target for pharmacological management of acute or chronic pain. Plants are not unique in their capacity to produce chemical agents that target sensory neurons or other excitable cells. Indeed, venoms from animals (ranging from arachnids to mammals) represent a vast pharmacopoeia that has great potential to yield novel agents with which to identify or characterize receptors, ion channels, or other signaling molecules that contribute to sensory transduction. Indeed, in the previous funding period we identified two such toxins - one from spider and another from snake - that serve as novel, potent, and highly selective agonists for TRPV1 and ASIC1 channels, respectively. In each case, these toxins enabled elucidation of the activated, fully open state of the channel at atomic resolution, providing unprecedented insights into structural mechanisms underlying channel gating and modulation. This proposal builds on our success and expertise in toxin discovery and characterization, with the goal of expanding the repertoire of pharmacological agents with which to study known or novel somatosensory receptors.
The first aim i s focused on characterizing two spider toxins that we identified in a sensory neuron- based screening assay, and which target a specific voltage-gated sodium channel (Nav) subtype expressed by these cells. We propose to identify the Nav channel domain(s) that specifies toxin sensitivity and accounts for its subtype selectivity. Furthermore, we shall test toxin selectivity in vivo using mouse genetics, and identify the subpopulation of sensory neurons that mediate the excitatory and algogenic actions of these toxins in cellular and behavioral paradigms.
The second aim i s focused on characterizing two novel toxins - one from centipede and the other from snake - that we also identified by functional screening, and which activate primary afferent sensory neurons to elicit nocifensive responses in mice. We propose to identify the molecular targets of these toxins and determine the signaling mechanisms through which they activate sensory neurons of the pain pathway. These studies will uncover novel sensory transduction molecules and/or provide powerful new tools for determining how known transducers work to modulate nociceptor excitability. Information gleaned from this work will provide important pharmacologic leads and insights pertinent to the development of analgesic agents.
Cell surface receptors and ion channels play essential roles in cellular communication throughout the body, including all aspects of nervous system function. In this proposal, we describe strategies for discovering and exploiting natural toxins with the goal of developing new tools with which to study the structure and function of receptors and ion channels that contribute to pain sensation. Results from this work will provide a more in- depth understanding of how these receptors and channels respond to noxious (pain-producing) stimuli under normal and/or pathological conditions, all of which is relevant to elucidating processes that contribute to acute and chronic pain. Results from these studies will provide important new information for the rational design of novel therapeutic drugs that target receptors and channels whose activities contribute to a variety of persistent pain syndromes.
|Osteen, Jeremiah D; Sampson, Kevin; Iyer, Vivek et al. (2017) Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes. Proc Natl Acad Sci U S A 114:6836-6841
|Zhang, Chuchu; Medzihradszky, Katalin F; Sánchez, Elda E et al. (2017) Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release. Proc Natl Acad Sci U S A 114:E2524-E2532
|Gao, Yuan; Cao, Erhu; Julius, David et al. (2016) TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature 534:347-51
|Osteen, Jeremiah D; Herzig, Volker; Gilchrist, John et al. (2016) Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature 534:494-9
|Cao, Erhu; Cordero-Morales, Julio F; Liu, Beiying et al. (2013) TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron 77:667-79


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Where I live, we entered into another lockdown which included a 2week extension. Schools have been closed for weeks, and businesses including restaurants have either temporarily closed, permanently closed or have become delivery/pickup only. There is no question that this is a hard time. We are all tired, exhausted and very frustrated. We all wantContinue reading "Parenting Through A Pandemic"
Tag Archives: COVID19
Getting Through It
Sometimes I need to be heard. Sometimes I need to feel that my feelings matter and by feeling this way, it's OK. Often times when I express various emotions to someone, my feelings often get lost along the way. Either the person I am expressing them to is perhaps going through something of their own.Continue reading "Getting Through It"

subset: commoncrawl


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text: 14:00:36 <davidsha> #startmeeting network_common_flow_classifier 14:00:38 <ruijie_> sorry davidsha :( 14:00:38 <openstack> Meeting started Tue Nov 14 14:00:36 2017 UTC and is due to finish in 60 minutes. The chair is davidsha. Information about MeetBot at http://wiki.debian.org/MeetBot. 14:00:39 <openstack> Useful Commands: #action #agreed #help #info #idea #link #topic #startvote. 14:00:41 <openstack> The meeting name has been set to 'network_common_flow_classifier' 14:00:53 <davidsha> ruijie_: No problem I've made the mistake myself! 14:01:03 <davidsha> Hi everyone! 14:01:06 <igordc> hi davidsha 14:01:19 <bcafarel> hi guys 14:01:25 <igordc> hi bcafarel 14:01:57 <davidsha> we'll wait 2 mins for people to join, then start 14:03:55 <tmorin> o/ 14:04:00 <igordc> hi tmorin 14:04:05 <davidsha> Hey :) 14:04:10 <tmorin> hi igor ! 14:04:13 <davidsha> Lets start then 14:04:27 <davidsha> #topic CCF v0 - Update 14:04:53 <davidsha> So I need to update: https://review.openstack.org/#/c/499571/ 14:05:21 <tmorin> davidsha: yes, I think some improvements are needed 14:05:39 <davidsha> I'll try to draft another patch for functional tests 14:06:12 <tmorin> davidsha: do you think you could finish the functional job checking DB vs. models consistency *before* we merge the models ? 14:07:01 <davidsha> tmorin: thats my plan, but I'll also need to enable functional testing in governance/infra 14:08:31 <davidsha> I'll try to start into that next week. 14:09:24 <davidsha> I'll also try to respond to the comments on the patch soon too :) 14:09:48 <davidsha> I've read them, I just need to reply 14:10:01 * bcafarel still has to finish reading them :/ 14:10:23 <tmorin> ok 14:11:14 <davidsha> Are there any questions or anything anyone wants to bring up in regards to V0? 14:11:41 <igordc> all good here 14:12:12 <tmorin> davidsha: there is something I didn't look closely at yet: 14:12:26 <tmorin> davidsha: which is how the OVO objects code is unit-tested 14:12:50 <tmorin> davidsha: I haven't checked how much the unit test proposed in the change covers 14:13:09 <davidsha> tmorin: the only unit test for versioned objects is the hash to version check. 14:13:32 <davidsha> I haven't seen other types of unit tests for versioned objects in neutron. 14:13:57 <tmorin> davidsha: I have to look at this in another context, which might give me ideas (or not) 14:14:10 <tmorin> davidsha: I'll do suggestions if I have any... 14:14:24 <davidsha> tmorin: Cool, thanks! 14:15:14 <davidsha> I was talking to Ihar and he mentioned we should move the models to be more similar to QoS 14:15:57 <igordc> davidsha: in what way? 14:16:44 <davidsha> igordc: basically mapping classifications -> class groups like qos maps rules -> policies 14:17:15 <davidsha> we have a bit of a disconnect between out API and our DB models at the moment. 14:17:51 <davidsha> not in this patch but in this one: https://review.openstack.org/#/c/487182/ 14:18:46 <davidsha> basically we don't pipe it straight into an OVO, we have to extract the definition and mess with the API model to make it fit into the OvO 14:19:54 <davidsha> It kind of messes with the point of OVO 14:20:23 <igordc> davidsha: it difficults the grouping and boolean flexibility we have at the moment... but if it's worth it for the sake of getting the OVOs right then fine 14:21:17 <davidsha> igordc: Well we'll need to see as we review it, we might figure something out that makes it work. 14:21:51 <igordc> davidsha: sure.. I'd recommend looking at some of the conversations that were held in the spec with me, ihar, tmorin and others 14:22:00 <davidsha> igordc: kk 14:23:06 <davidsha> Will we move to open discussion? 14:23:22 <bcafarel> nothing to add on v0 here 14:23:29 <igordc> I'm not writing anything else atm :) 14:24:20 <davidsha> kk lets move on 14:24:35 <davidsha> #topic open disscusion 14:25:04 <davidsha> Any topics anyone would like to bring up? 14:26:11 <bcafarel> I guess you Irish folks will make it to the PTG? 14:26:56 <igordc> bcafarel: I probably won't... but I'm also not irish :p.. 14:27:20 <bcafarel> s/Irish/working near Dublin/ then? :) 14:27:41 <davidsha> I'm hoping to make it up, we're on the other side of the country though :) 14:28:41 <davidsha> Something else actually, I'm being moved off of OpenStack. 14:30:47 <davidsha> I'm going to try to stick around for reviews beyond the work I'm doing at the moment, but I'm not sure how much time I'll have. 14:31:09 <tmorin> bcafarel: if French Britany qualifies as "near Dublin", then count me ! 14:31:26 <tmorin> davidsha: yes, we heard about that... :-/ 14:31:33 <igordc> same with me, I've essentially moved off of OpenStack entirely already 14:31:35 <bcafarel> sean-k-mooney mentioned it yes :/ 14:31:55 <igordc> the closest to it I'm doing now is in OSM (open source mano) 14:32:59 <davidsha> Kk, Just said I'd make a formal announcement! 14:34:52 <bcafarel> davidsha: well same as when igordc stepped down a bit "thanks for the ccf work!" 14:35:41 <davidsha> bcafarel: Thanks 14:36:02 <davidsha> We can warp up now and get 25 mins back if no one has anything else? 14:36:38 <tmorin> yep 14:36:49 <bcafarel> sounds good to me (and hoping the ccf manages to keep some steam without you guys) 14:36:56 <tmorin> I echo that: thanks guys ! I hope/wish you'll have time to finish some pieces! 14:38:05 <davidsha> Cool, have a good day folks! 14:38:11 <davidsha> #endmeeting


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Getting a chance to see the rare, behind the scenes glimpses of Mulholland Drive is something that you might be interested in if you ever watched the movie. Since I have not watched it, only read about, I can say that it seems like a real mind bender and might actually confuse those who don't understand what's going on. The behind the scenes look however are something that shows just how the confusing and strange moments in the film were made. Like a lot of films it's very involved and has to be done in a manner that's very professional and even insanely precise at times.
The amount of takes that are needed to get everything down and everything the way it should be seem to be endless sometimes but thankfully between the director and the actors taking their cues it all gets done without too much difficulty. It does seem like the actors have to stand around quite a bit in order to wait for the sets to be ready and the action to finally get going. The amount of times that people either forget or flub their lines is something that has to get frustrating and yet dealt with in a way that seems to mollify everyone so as to keep the picture rolling and the general feeling at least copacetic enough to satisfy those that are directly involved, which would be everyone.
The setup of each scene, meaning the cameras and everything else that needs to be included in the scene, is immense. Even on a film that was not seen as an epic but is still considered to be one that people tend to like and discuss the setup seems absolutely insane and invasive in a way that astounds me when I think of how the actors have to do their thing with all this gear around them. There are cameras in front of them, lights above, and all sorts of gear all around them, and they still have to hit their mark and look as genuine as possible. That takes some serious skill on the part of the actors to block out everything else and just focus on their part.
I'm in awe of actors at times since they have to do and say certain things that don't make a lot of sense but are still a part of their job. The more intimate scenes are definitely something that takes some doing since a lot of folks in life have the belief that intimacy is something that you share between two people that really love each other. Actors have to do this on a constant basis with those that they might care about and respect but definitely do not love. It'd be even harder it seems to do such intimate moments with someone that you absolutely despise and cannot stand to be in the same room with. Yet actors kiss, touch, and go much further at times for movies in order to get the job done.
All of it's pretty impressive, especially when you get to look beyond the glam and see how it works.
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The 9-hole "Bassano Golf Course" at the Bassano Golf Course facility in Bassano, Alberta features all the hallmarks of Alberta golf. Bassano Golf Course opened in 1957. Jennifer Nishida manages the course as the General Manager.
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Emmy Award-Winning Media Mogul Pat Mitchell Wants You to Become risky
In some ways, 2020 looks like we're in a time warp to 1970. Forty years later, ladies nonetheless don't have equal safety below the regulation. Reproductive rights are below assault within the very states that reject social applications like welfare and meals stamps. Various power actions are being picked aside by the particular pursuits of the oil and fuel industries as we see the local weather disaster escalate. And males like Trump and Kavanaugh have been put in into positions of energy, regardless of obtrusive proof of their abuses towards ladies. With the stakes this excessive—this harmful—ladies like Pat Mitchell are preventing again.
"I believe that it's time for us—women and the men who stand with us…to embrace risks and engage with renewed passion and collective purpose in the truly dangerous work of making the world safer for women and girls."
For practically 4 many years, Mitchell has been sharing the tales of ladies as an award-winning journalist, producer, curator, media govt and now writer of Turning into a Harmful Girl. We sat down along with her on the annual TEDWomen convention in Palm Springs to focus on her TED discuss on her new guide, the artwork of activating a group of ladies and the teachings our era can take into this new decade.
Emily Joffrion: Your memoir opens with a scene in playwright Eve Ensler's home the place ladies have been gathering to discuss by way of the 2016 election. How did you come to undertake the title Harmful Girl?
Pat Mitchell: That was a particular second in our nation—proper after that polarizing election—specifically due to the position ladies, notably white ladies, performed within the election. Eve Ensler gathered all kinds of ladies leaders collectively, from Black Lives Matter to Greenpeace. I used to be thrilled to get the invitation, however I didn't notice till I sat down in that circle precisely who was within the room.
I had simply left my final full time CEO job and it was the primary time I had to introduce myself with out a recognizable title. As folks went across the room sharing their credentials, the listing grew to become ever-more spectacular and intimidating. It was a defining second as I handled how to introduce myself and what would make sense within the current—not simply what I had accomplished up to now. We had been speaking about harmful instances and being stuffed with concern and fear, so the idea of harmful was within the forefront of my thoughts. When it got here to be my flip, I stated, "I'm Pat Mitchell.
And I am a Dangerous Woman. At this time in my life, I have nothing left to prove less to lose, and I'm ready to take more risks and be less polite." As soon as I stated it, it felt so proper. It feels extra proper each day.
Joffrion: That evening at Ensler's, you share in regards to the stress you had introducing your self with out a present title. It resonates so deeply as a result of our society has taught us that we're what we do. While you don't have the correct model or title behind you, who're you to be within the room?
Mitchell: That's what occurs with introductions, particularly should you're instructed, as ladies usually are, to very briefly show who you're and what you've accomplished. You clearly need to say one thing that identifies what you've accomplished with out bragging—which is the opposite factor ladies have to navigate. I discover males by no means fear about introductions, have you ever observed that? They'll take a full thirty minutes to inform you all of the issues they've accomplished. Since that second, I pay much more consideration to how folks introduce themselves and the way I introduce others as a result of it does set up an identification. Prefer it or not. Which is why I inform folks not to use my former titles. It's good that I had them, it's good that I did that work. However that's not who I'm within the current second.
Joffrion: You speak about your age as a privilege—the privilege of getting much less to lose. What position do you see for girls out of your era in social justice work?
Mitchell: I don't assume it's about an age, however the details are that ladies from my era are largely freed from the duty of elevating youngsters and many people are prepared. I believe that older ladies have a very vital position to play now as a result of there are extra of us. We aren't retiring, we're rewiring! That's an thrilling potential for change and I'll maintain taking that decision to motion in every single place I can. I usually hear ladies say, "I'm on the Dangerous side of 60. I'm ready to go!" And they're! But that is the time after we get pushed off of company boards, we get pushed out of jobs. A few of that's altering however not sufficient of it. There's nonetheless plenty of work to do.
Joffrion: One of many issues that units you aside from different leaders is your expertise for bringing communities of ladies collectively. What's your secret?
Mitchell: There are all of these items that work towards ladies working collectively. Usually we're in environments the place there's just one or two of us and we really feel like we now have to be in competitors with one another. However I spent most of my profession working with ladies and for girls, so I come into it with a special perspective. I search for ladies as collaborators and companions and pals. My ladies pals are my supply of renewable power. TEDWomen is an efficient instance of how ladies could make all of the distinction by displaying up for each other. Once I began going to TED, it was actually in a person's world. There have been solely about ten ladies in attendance and we have been at all times within the additional room, by no means within the theater. However I liked the concepts that have been shared, so I went for a few years. I advocated for extra ladies's voices to be included and received help from Chris Anderson, TED's Curator. I launched what I needed to do to the ladies curators with the supply of help, partnership and advocacy and we grew to become a group from the start. My recommendation? Go into a corporation that has sturdy ladies and produce them collectively to collaborate and help one another.
Joffrion: How do you cope with criticism that tales or concepts coming from ladies are much less precious than these coming from males?
Mitchell: It's onerous to consider that we're nonetheless speaking about equal pay for equal work, however it's nonetheless a indisputable fact that many ladies are nonetheless being paid lower than their male colleagues doing the identical job and with the identical {qualifications}. Within the guide, I write in regards to the expertise of negotiating my wage once I was working as a producer and a broadcast journalist: working two full time jobs for a wage that was decrease than that of my male colleagues, my request for a elevate was denied and the excuse was that he had a household to help.
So did I, as a single mother. Wage is a mirrored image of price, so if you inform a girl she has to work twice as onerous for half as a lot, you're indicating that she is much less valued. This worth system has permeated our collective consciousness, and it has, in lots of situations, additionally turn out to be a self imposed barrier for girls who internalize that they've much less worth. This could additionally lead us to go towards our personal self pursuits as ladies—voting for males who denigrate and devalue ladies, for instance, which thousands and thousands of ladies did within the final election. It will possibly additionally lead to our not supporting different ladies's initiatives or worth. After we launched TEDWomen, the most important critics of the concept at first have been different ladies who someway believed that if was a convention of ladies audio system, it had much less worth. "Don't create a 'pink' TED," was one of many feedback.
Joffrion: What's the concept price spreading out of your guide and TED Discuss?
Mitchell: It's an concept I first heard from a harmful, risk-taking congresswoman from New York named Bella Abzug. She stated, "In the 21st century, women will change the nature of power rather than power changing the nature of women." From the second I heard that, I assumed—that is our name to motion. That is our greatest alternative. As a journalist and an activist, I've seen this concept in motion. As we transfer ahead in our lives and work and we now have extra energy and affect, let's change the character of energy by dismantling a few of the boundaries that stay for individuals who observe. By advocating and educating for fairer, more true and extra equal illustration in each room and at each desk. Not to play the facility sport, however to lead to higher outcomes for everybody.
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text:
Dave Chappelle asked the audience during his comedy show to "make some noise for the richest man in the world".
The spectators roared. Lots of boos.
It was a pretty uncomfortable performance for Twitter's new owner Elon Musk at Dave Chappelle's show with Chris Rock on Sunday night at the Chase Center in San Francisco. At the end of the show, the comedian talked about the need to associate and communicate with people with different perspectives and views.
He invited Elon Musk on stage. The billionaire agreed, and loud boos filled the arena with cheers.
Chappelle's reaction
Chappelle joked with Musk that he was probably dealing with "people he fired." As boos continued to ring out, the comedian pointed out that anyone who was upset was in "bad seats".
Twitter has undergone massive changes since Elon Musk took over the social media platform, with the first few weeks of his tenure marked by widespread firings and the reinstatement of several suspended accounts, including former President Donald Trump's and Rep. Marjorie Taylor Greene.
Musk stayed on stage for a long time, shaking hands with many artists who had joined Chappelle. Spectators had been asked to lock their phones during the show, but a few videos of the event surfaced online.
To see in video


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Problem A
Let's first solve a simpler problem – when the sequence 𝑐 is cyclic, i.
e. when 𝑐𝑖 = 𝑐𝑖 𝑚𝑜𝑑 𝑁 , for 𝑖 ≥ 0.
This simpler version is similar to Fibonacci sequence. Actually, for 𝑁 = 1
and 𝑐0 = 1, it is the Fibonacci sequence. To find the 𝐾 𝑡ℎ number of these
kind of recursive sequences fast we should first write them in their matrix
form. Matrix form of this sequence is:
( 𝑖 ) = ( 𝑖−1 𝑖−2 ) ( 𝑖−1 )
Expanding this, we can see that
𝑐 𝑐𝑖−1
( 𝐾 ) = 𝐶𝐾−1 𝐶𝐾−2 … 𝐶2 𝐶1 ( 1 ), where 𝐶𝑖 = ( 𝑖
How do we calculate this efficiently?
For relatively small 𝐾, and we will take 𝐾 < 𝑁 for this case, we can
For large 𝐾 (𝐾 ≥ 𝑁), we will take advantage of the fact that 𝑐 is cyclic.
Since 𝑐 is cyclic with cycle of length 𝑁, we know that 𝐶𝑁−1 𝐶𝑁−2 … 𝐶1 𝐶0 =
𝑐 𝑐
𝐶𝑖𝑁+(𝑁−1) 𝐶𝑖𝑁+(𝑁−2) … 𝐶𝑖𝑁+1 𝐶𝑖𝑁 , for 𝑖 ≥ 0 (note that 𝐶0 = ( 0 𝑁−1 ) ).
Let's define this product of matrices as 𝑆 = 𝐶𝑁−1 𝐶𝑁−2 … 𝐶1 𝐶0 .
Now, we can write a formula for 𝐹𝐾 that can be calculated quickly:
) = 𝐶𝑎−1 𝐶𝑎−2 … 𝐶1 𝐶0 𝑆 𝑏 𝐶𝑁−1 𝐶𝑁−2 … 𝐶2 𝐶1 ( 1 ), where 𝑏 = (𝐾 −
𝑁) 𝑑𝑖𝑣 𝑁 and 𝑎 = 𝐾 𝑚𝑜𝑑 𝑁.
We can calculate 𝑆 𝑏 in 𝑂(𝑙𝑜𝑔𝑏) steps using exponentiaton by
squaring, and then we can just multiply everything in the expression to get
𝐹𝐾 quickly.
Let's get back to the full problem, when 𝑐 is almost cyclic. In this
case, we cannot just use 𝑆 𝑏 in the formula above, because some matrices in
𝑆 𝑏 may not respect the cyclic property. Instead of 𝑆 𝑏 , we will have
something like
𝑆 ∙ 𝑆 ∙ … ∙ 𝑆 ∙ 𝐸1 ∙ 𝑆 ∙ 𝑆 ∙ … ∙ 𝑆 ∙ 𝐸2 ∙ … = 𝑆 𝑡1 ∙ 𝐸1∙ ∙ 𝑆 𝑡2 ∙ 𝐸2 ∙ 𝑆 𝑡3 ∙ …
where 𝐸𝑖 denotes the product of matrices of the cycle, with some matrices
being different than the matrices of the original cycle. Also, 𝑖 ≤ 2𝑀 since
each of the 𝑀 values of 𝑐 different than values of the original cycle appears
in exactly two matrices, so at most 2𝑀 of cycles are affected.
We can still calculate each 𝑆 𝑡𝑖 quickly, using exponentiation by squaring.
Since there are at most 2𝑀 of those, total complexity of this would be
Now we only need to calculate each 𝐸𝑖 . Naive way would be to just
multiply all matrices of 𝐸𝑖 . Since the number of matrices is 𝑁, this would be
𝑂(𝑁𝑀) worst case, which is too slow. To quickly calculate 𝐸𝑖 , we will
initially create a segment tree of matrices, with matrices of original cycle in
the leaves. Internal nodes of the tree will represent the product of their
children. This means that the root will represent the product of all matrices
in the cycle. To calculate 𝐸𝑖 , we will just update our segment tree with those
values that are different than the original values of the cycle. We will do this
by updating corresponding leaves of the tree, moving up to the root and
updating the products in the internal nodes. After we're done updating the
tree with all of the matrices that are different than matrices of the original
cycle, we will just use the product in the root of the tree. Finally, we will
update the tree back with matrices of the original cycle in order to reuse the
segment tree for 𝐸𝑖+1 .
Since there are 𝑂(𝑁) nodes in the segment tree, the complexity of
updating is 𝑂(𝑙𝑜𝑔𝑁). The total complexity is then 𝑂(𝑀𝑙𝑜𝑔𝑁 + 𝑀𝑙𝑜𝑔𝐾).
We should also mention that the constant factor is not very small, since we
operate on matrices and not just integers.
Note that we need to find 𝐹𝐾 𝑚𝑜𝑑 𝑃 and 𝑃 may not even be a prime number.
However, this does not affect us since we only deal with operations of
addition and multiplication throughout the whole procedure and we can just
do them all modulo 𝑃.
Problem B
Let us first provide a suitable interpretation of the task description.
The country can obviously be represented as an undirected graph, where
vertices are towns and edges are roads. We see that it is connected (the
description mentions that every city is reachable), but we also know that
there are 𝑁 − 1 edges, where 𝑁 is the number of vertices. From this it
follows that the graph is, in fact, a tree. For the sake of simplicity, let us
make this tree rooted at node 1.
Let us consider just an 𝑎 ⇝ 𝑏 transfer. From the previous assertion it
follows that the cheapest path from 𝑎 to 𝑏 will always be the shortest path
from 𝑎 to 𝑏 – which is, in fact, the only path from 𝑎 to 𝑏 that does not have
any repeated vertices. Borna's trip is thus uniquely defined by all of his
stops. Getting from town 𝑎 to town 𝑏 requires that Borna first goes to the
lowest common ancestor (LCA) node of 𝑎 and 𝑏, and then descends to 𝑏
(note that the LCA can also be any of the nodes 𝑎 and 𝑏!). Computing the
LCA of two vertices is a well-known problem and may be solved in several
different ways. One possible approach is to use the equivalence between
LCA and the range minimum query (RMQ) problem and then compute the
LCA of any two vertices in constant time. Another one is based on heavy
path decomposition. In any case, we need to be able to compute the LCA in
𝑂(1) time.
Let us now define the notion of a banned (directed) edge: a directed
edge 𝑎 → 𝑏 is banned if it requires paying a bribe. If 𝑎 is the parent of 𝑏 for
a banned edge 𝑎 → 𝑏, then we call 𝑎 → 𝑏 a down-banned edge. Similarly,
we may define up-banned edges. If Borna traveled along a banned edge 𝑝
times, then he will have to prepare 1 + 2 + ⋯ + 2𝑝−1 = 2𝑝 − 1 thousands
of dinars for bribing the police. Hence we need to determine the number of
times every edge was traversed. This depends on whether the edge is downbanned or up-banned.
Before delving into these two cases, we need to compute the following
three properties for every town 𝑥:
𝑒𝑛𝑑𝑠_𝑑𝑜𝑤𝑛: the number of times 𝑥 was the final stop in a path, this is
equal to the number of occurrences of 𝑥 in the array of stops;
𝑒𝑛𝑑𝑠_𝑢𝑝: the number of times 𝑥 was the highest stop in a path, this is
equal to the number of times 𝑥 was the LCA of two consecutive stops;
𝑔𝑜𝑛𝑒_𝑢𝑝: the number of times 𝑥 was the first stop in a path.
Now we consider the cases:
If an edge 𝑎 → 𝑏 is up-banned, then the number of times it was
traversed is equal to the number of times any vertex in 𝑎's subtree was
an initial stop, minus the number of times any vertex in 𝑎's subtree
was the highest stop (i.e. sum of all 𝑔𝑜𝑛𝑒_𝑢𝑝's minus the sum of all
𝑒𝑛𝑑𝑠_𝑢𝑝's). We may compute these parameters for all vertices at
once using just one post-order tree traversal. Thus we can compute the
'bribe contributions' of all up-banned edge in linear time.
If an edge 𝑎 → 𝑏 is down-banned, then the number of times it was
traversed is equal to the number of times any vertex in 𝑏's subtree was
a final stop, minus the number of times any vertex in 𝑏's subtree was
the highest stop (i.e. sum of all 𝑒𝑛𝑑𝑠_𝑑𝑜𝑤𝑛's minus the sum of all
𝑒𝑛𝑑𝑠_𝑢𝑝's). Similar to the previous case, we can compute the 'bribe
contributions' of all down-banned edges using only one post-order
tree traversal.
Hence, by first computing 𝑒𝑛𝑑𝑠_𝑑𝑜𝑤𝑛, 𝑒𝑛𝑑𝑠_𝑢𝑝 and 𝑔𝑜𝑛𝑒_𝑢𝑝 for every
vertex, and then traversing the tree, we are able to compute the answer. The
final complexity depends on the implementation of LCA. The
asymptotically optimal solution to this problem has 𝑂(𝑁 + 𝐾) time
complexity, but even an 𝑂(𝑁 log 𝑁 + 𝐾) approach is acceptable given these
Problem C
The most naïve solution would be going through C(N, N/2)
combinations of assignments half of people to Friday and another half to
Friday and every time run Hungarian algorithm and just output the best
answer among them. However time complexity of this solution would be
O(C(N,N/2)*N^3) and O(N^2) memory – this won't pass time limit. To
explain solution of this problem let's describe the scheme of Hungarian
for (int i = 0; i < n; i++)
Hungarian algorithm allows rows to be added one by one,
in O(n2) each. So in this problem the only thing you had to do is to
recursively go through all sets of binary masks with equal number of 0s and
1s (where 0 in i-th position means that i-th person would go partying on
Friday, 1 – Saturday) and run Hungarian algorithm for this matrix. If done
recursively complexity would be O(C(N+2,N/2+1) * N^2). You can see
editorial for problem H to see why the number of vertices in that trie would
be C(N+2, N/2+1).
Dp cannot be used here because of low ML.
Problem D
First notice that parity of thief's 𝑋 coordinate changes every time he
moves. Assume that at the beginning 𝑋 coordinate of thief's position is odd,
and check districts (1, 1) and (1, 2). The next day check districts (2, 1) and
(2, 2) and so on until 1000𝑡ℎ when you check districts (1000, 1) and
(1000, 2). What is achieved this way is that if starting parity was as
assumed, thief could have never moved to district with 𝑋 coordinate 𝑖 on day
𝑖 + 1, hence he couldn't have jumped over the search party and would've
been caught. If he wasn't caught, his starting parity was different than we
assumed, so on 1001𝑠𝑡 day we search whatever (1 and 1001 are of the same
parity, so we need to wait one day), and then starting on 1002𝑛𝑑 day we do
the same sweep from (1, 1) and (1, 2) to (1000, 1) and (1000, 2) and
guarantee to catch him.
Shortest possible solution is by going from (2, 1) and (2, 2) to
(1000, 1) and (1000, 2) twice in a row, a total of 1998 days, which is
correct in the same way. First sweep catches the thief if he started with even
𝑋 coordinate, and second sweep catches the thief if he started with odd 𝑋
Problem E
First we simplify the problem by replacing the initial set of points
with the set of all points where some fan might appear after one second, call
that set S. Every point in S has a probability that a specific player will appear
there. Consequently, for every point P in S we know the expected number of
fans at it after one second, call it P_e .
Now, for some arbitrary circle that passes through some three points
of S (which doesn't violate the rules of the problem), the expected number of
fans caught on camera is the sum of all T_e, where T is a point on or inside
the circle. Our goal is to find a circle that maximizes that sum.
After drawing a few examples, we can notice that we can always
catch most of the points that are possible locations of some fan or even all of
them. We can write a brute-force solution that will increase our suspicion
that all fans can be caught, no matter how they move.
Now let's try to find the largest circle of those that surely catch all
fans and don't violate the rules in the problem. It is easy to see that three
fixed points that determine the circle must lie on the convex hull of S
(otherwise we surely wouldn't catch all points of S with that circle).
Convex hull can be computed in |S|log(|S|) which might be too slow if
unnecessary points are not eliminated from S.
Notice that for every fan in input, if his speed is v, he might appear at
O(v ) points, so convex hull algorithm would have O(Nv2log(Nv))
complexity, which is too slow.
The trick is to take only convex hull of those O(v2) points, which will
have O(1) points. All other points should be eliminated from S as they don't
have a chance of appearing on convex hull of S. Contestants need to be
careful with edge cases when a fan potentially goes out of the field.
After computing the convex hull of S (call it H(S) ), we hope to find
the circle that will pass through some three points on that hull and contain all
other points inside it or on it.
These two claims can be proven geometrically:
1) For a convex polygon, the largest circle among all circumcircles of
triangles determined by the polygon vertices will surely contain all
vertices of the polygon on it or inside it.
2) For a convex polygon, the largest circumcircle of some triangle that is
determined by vertices of the polygon is a circumcircle of a triangle
that contains three consecutive vertices of a polygon.
With 1) and 2) we conclude:
The largest circle among those that are circumscribed around triangles that
are composed of three consecutive vertices of H(S) contains all of the points
of H(S) (and then obviously of S) and no other circle that contains all those
points can be larger.
This means that we can finish the problem easily in linear time (with respect
to the size of convex hull).
Problem F
First, let's consider solution in 𝑂(𝑛 ∗ 𝑚𝑎𝑥𝑋) complexity. It's a simple
dynamic programming approach.
We have an array 𝑑𝑦𝑛 (size 𝑚𝑎𝑥𝑋), which should say how costly
would it be to be in this position at the end of the turn. At initialization step
each position is set to 𝑚𝑎𝑥𝑉𝑎𝑙𝑢𝑒 (some big number), except the initial
position which is set to be 0. This should represent that in the initial moment
it's impossible to be anywhere except in the initial position.
Before each turn we can change position, so before each turn we
could calculate the best cost of being in that position when the bulbs light
up. We can do this by passing this array twice – once from the left and once
from the right. Consider the case we're passing from left to right (smaller
index 𝑖 to larger index 𝑖, the other case could be explained in the similar
fashion). While passing, we can keep the 𝑏𝑒𝑠𝑡𝑉𝑎𝑙, which would be initiated
to 𝑑𝑦𝑛[0], and updated as 𝑏𝑒𝑠𝑡𝑉𝑎𝑙 = 𝑚𝑖𝑛(𝑏𝑒𝑠𝑡𝑉𝑎𝑙 + 1, 𝑑𝑦𝑛[𝑖]), 𝑑𝑦𝑛[𝑖] =
𝑏𝑒𝑠𝑡𝑉𝑎𝑙 for each 𝑖 > 0. Rationale: if we came from the 𝑖 − 1 position we
have the same cost of that position +1, if we didn't we have the same cost
we had before this exercise. Now we only need to add distance to the closest
bulb for each position and we finished this turn. When we finish each turn
we pick the lowest value in the array, and that's our solution. Simple
But this solution is too slow for us. We want more.
Statement: We never have to move to the position which is not beginning or
the end position of one of the light-ups.
Let's consider following situation: We're at the position 𝑥 . If 𝑥 is
going to be inside of the next turn shining bulbs, there's no point of moving
at all (it would be the same as moving after the turn). So, consider 𝑥 is
outside those bulbs, and 𝑥𝑐𝑙𝑜𝑠𝑒𝑠𝑡 is the closest bulb to 𝑥 that will be lightenup. Also, consider 𝑥 < 𝑥𝑐𝑙𝑜𝑠𝑒𝑠𝑡 (the other case could be explained in the
similar fashion). Consider all the remaining light-up points (light-up
beginning and end positions) are in the array 𝑝𝑜𝑠, which is sorted. Take a
look at the following picture:
𝑝𝑜𝑠 ′
𝑝𝑜𝑠 ′′
First thing we could notice is the fact that our cost for this turn is going to be
𝑥𝑐𝑙𝑜𝑠𝑒𝑠𝑡 − 𝑥, if we finish the turn anywhere between 𝑥 and 𝑥𝑐𝑙𝑜𝑠𝑒𝑠𝑡 inclusive.
Going left from 𝑥 or right from 𝑥𝑐𝑙𝑜𝑠𝑒𝑠𝑡 doesn't make any sense, because we
would have same or bigger cost than staying in 𝑥 or 𝑥𝑐𝑙𝑜𝑠𝑒𝑠𝑡 and moving
from it in the next turn.
Next, let's consider we haven't ended our turn on some light-up
endpoint, but between two neighboring endpoints, 𝑝𝑜𝑠 ′ and 𝑝𝑜𝑠 ′′ . Let's call
that position 𝑥𝑡𝑢𝑟𝑛 . Let's also introduce 𝑥𝑐𝑙𝑜𝑠𝑒𝑠𝑡2 , which is the closest bulb
from the 𝑥𝑡𝑢𝑟𝑛 in the next turn light-up.
If 𝑥𝑡𝑢𝑟𝑛 is shining, then 𝑝𝑜𝑠 ′ is shining as well, so we could have
finished our turn there. If 𝑥𝑐𝑙𝑜𝑠𝑒𝑟2 ≤ 𝑝𝑜𝑠 ′ we would be better off or equally
well if we finished our turn in 𝑝𝑜𝑠 ′ . In that case we would have 𝑥𝑡𝑢𝑟𝑛 −
𝑝𝑜𝑠 ′ smaller cost for the next turn. If afterwards we need to go to 𝑥𝑡𝑢𝑟𝑛 ,
total cost would not exceed the cost of going straight to 𝑥𝑡𝑢𝑟𝑛 in the initial
turn. If 𝑥𝑐𝑙𝑜𝑠𝑒𝑟2 ≥ 𝑝𝑜𝑠 ′′ we would be better off or equally well if we
finished our turn in 𝑝𝑜𝑠 ′′ , similar to the explanation for 𝑝𝑜𝑠 ′ . So, in each
turn we could stay in the place or go to the closest light-up endpoint and we
could still get the optimal solution.
We can use this fact to make a 𝑂(𝑛2 ) solution – instead of each
position we should take consider only light-up endpoints and initial position.
Everything else is the same as in original solution.
Dynamic programming solution is enough to pass within the constraints for
the program, but this problem can be solved in linear time as well.
Let's look at the values of array 𝑑𝑦𝑛. We can notice that this array actually
has only one local minimum at each turn. What this means is that we have a
range [𝑙, 𝑟] and that all of the values from 𝑑𝑦𝑛[0] to 𝑑𝑦𝑛[𝑙] are
monotonically decreasing, all values from 𝑑𝑦𝑛[𝑟] to 𝑑𝑦𝑛[109 ] are
monotonically increasing, while all of the values 𝑑𝑦𝑛[𝑙], 𝑑𝑦𝑛[𝑙 +
1], … , 𝑑𝑦𝑛[𝑟] have the same value and represent the minimum summed cost
until this turn. We can use this property to create a linear time algorithm.
Our linear algorithm will be as follows:
At the beginning, our optimal range will be [𝑥𝑠𝑡𝑎𝑟𝑡 , 𝑥𝑠𝑡𝑎𝑟𝑡 ] and minimum
cost will be 0. At each turn, we will update this optimal range and minimum
If the range of shining bulbs in the next turn intersects with our
optimal range, we can easily see that our new optimal range will be this
intersection. The minimum cost will stay the same as cost for previous turn,
since we don't need to move if we are located somewhere in this
intersection, as we will already be located at a bulb that is shining.
Anywhere outside of this intersection, the cost would increase since either
the distance to the closest shining bulb would be larger than 0, or because of
moving from our optimal range to somewhere outside of it, or both.
If the range of shining bulbs in the next turn does not intersect our optimal
range and is left from our it, we will set that our optimal range is from the
rightmost shining bulb to the left end of our previously optimal range. Our
minimum cost will increase for exactly the distance between these positions
– if we don't move from the left end of our previously optimal range, our
cost increases for this distance. If we move from the left end of our
previously optimal range by one position to left, we decrease our distance in
the next turn by 1, but increase the cost by 1 because of the move. Same
goes for moving two positions to left, and so on until movement to the
rightmost shining bulb in the next turn (at which point our distance to
shining bulb will be 0, but our cost for moving will be the same as distance
when we didn't move at all). It is easily seen that the minimum cost for a
position that is left from this new optimal range is larger by 1, and the
minimum cost for a position that is right from this new optimal range is also
larger by 1. Moving further to the left or right, this cost increases more and
more, resulting in only one local minimum as we described previously.
If the range of shining bulbs does not intersect our optimal range and is right
from it, we can do a similar thing as we do when the range is left from our
optimal range.
After all the turns, we have our optimal range and the minimum cost
possible. The total complexity is 𝑂(𝑛), since in each turn we update the
range in 𝑂(1).
Problem G
The problem can be restated as follows: given an undirected graph.
Consider any path with edge lengths l0, l1, …, llen - 1. It's cost is
l0 + 10l1 + … + 10len - 1{llen - 1}. We need to find the cost of the cheapest path
from 0 to n - 1 and output it.
For now let's ignore the leading zeros. Notice that the distance after
walking the edge (u, v) can be obtained by putting the length of this edge in
front of the distance to get to u . So the trivial solution is to run BFS from
vertex 0 and store for each vertex the smallest number to get to it. But it will
run in O(N2) time because we will have to compare large number in order to
get the best one for each vertex.
In order to avoid it we can store the equivalence classes instead of
actual numbers, so that we could compare their classes, not actual numbers.
The vertex 0 will have class 0. We will split the graph into layers.
The kth layer will have vertexes with length of distance exactly k. Now
process the graph layer by layer. For kth layer we know all equivalence
classes, let's obtain the {k + 1}st layer and all the equivalence classes for it.
Imagine we walked some edge (u, v) with length l. The distance
to v d(v) will be
. If we need to compare two numbers with the same
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Synopsis: After conquering all but two of the islands, Daemon declared himself King of the Stepstones and the Narrow Sea, being crowned by Corlys the Sea Snake.
The Story
Having defeated the Crabfeeder in last week's episode. Daemon has declared himself the King of the Stepstones and the Narrow Sew and has returned to King's Landing. Initially welcomed back by Viserys. All appears to be well. However, the Kingdom is still preoccupied with finding a suitable husband for Princess Rhaenyra who is not cooperating. Making matters worse. Daemon takes Rhaenyra on a little adventure beyond the Keep where they go drinking, watch a piece of theatre, and end up in a brothel. Daemon attempts to seduce the princess but thankfully pulls back from his urge to do so. Just as well given that it would have been pretty incestuous and it was not the most comfortable thing to watch. Unfortunately, The Hands Spies are watching and reports of this get back to the King. Although the reports claim that Uncle Daemon and his Neice Rhaenyra went through with the deed.
Suffice it to say that Rhaenyra's position within the King's court is compromised. The perception of her should word get out will change and not for the better. Also, Rhaenyra's attraction to Ser Criston Cole heats up. However, The King has chucked a bucket of cold water over it as he proclaimed that Rhaenyra will have to marry The Sea Snakes' son.
The Acting
Matt Smith and Milly Alcock both put in a strong performance this week as this gets a bit heated. The scenes of Daemon and Rhaenyra's night on the town together have set up all sorts of implications that will likely play out over the coming weeks. We also get strong performances from Paddy Considine and Rhys Ifans as Viserys and Hightower find themselves potentially at odds.
This was a pretty strong episode, which further explored the politics and dodgy dealings within this series. The scenes of Daemon and Rhaenyra together were done well. I really liked the juxtaposition of Daemon and Rhaenyra's scenes with those of the King and his young wife Alicent who appears to be barely tolerating her king's touch out of a sense of duty as opposed to her getting any pleasure from it. That scene alone makes the scene later on when Alicent questions Rhaenyra so much more potent.
- Story8.8
- Acting9.7
- CGI & Stunts9.8
- Incidental Music9.3


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Best known for her long-running Broadway version of Hello Dolly, actress/singer Carol Channing says that even in the depth of the Depression, her San Francisco public middle school had the arts. So she really doesn't understand why so many public schools these days, claiming the need for cutbacks because of the national recession, are dumping music, poetry, visual arts and dancing.
"We had the arts and they changed us completely," the three-time Tony Award winner told Art Attack. The 90-year-old Channing is on her way to Houston to accept the Anne Morrow Lindbergh Award for Living With Grace and Distinction from the Huffington Center on Aging at a luncheon at the River Oaks Country Club on October 26. A question-and-answer session will be part of the event.
That night she'll step over to the Barnes & Noble store in the River Oaks Shopping Center to give Houstonians an advance look at a patriotic CD she's just done, entitled Carol Channing: True to the Red, White and Blue.
During a lively interview with Channing and her 91-year-old husband Harold Kullijian -- on speaker phone they each chimed in as the spirit moved them -- Channing said a large part of her effort criss-crossing the country urging schools to retain the arts is because of Kullijian. "It's the dream of his life," she said simply.
For his part, Kullijian said, "In this case, where public schools have constantly eliminated the arts, they have basically taken away one of the basic catalysts to learning. And all over the world, the better educational systems of the world have been shown over and over again to have the arts in their curriculum."
The two founded the Dr. Carol Channing and Harry Kullijian Foundation for the Arts, and spend their time urging local school boards not to forsake the arts and deciding where best to apply the money they raise.
Channing quoted liberally from Albert Einstein and his discovery of how to split the atom. She said Princeton asked Einstein to appear one time before a meeting of physicists to explain his theory of relativity.
"He came in and brought a violin case. They asked him to speak for an hour. He said, 'Instead of speaking for an hour, I'm going to do a violin solo and maybe you will begin to see and feel the harmony of the universe.' Well of course they didn't. I can't imagine what Princeton University thought. At the end of that, he said, 'Most every great physicist and scientist, most every one of them is a good artist and a fine artist. And those that aren't artists, don't get it.'"


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Salt and pepper bowl olive wood
Handmade olive wood salt and pepper bowl from popular Gharyan. The lid is attached with a magnet so that it does not fall off.
D: 10 cm
H: 7 cm
- Food safe
- Not dishwasher
- Do not soak in water
- Hand wash with mild detergent and lukewarm water
- Do not air dry but dry with a towel when wet
- Lubricate with olive oil once a month so that the wood retains its luster
- Handmade
- Material: Olive wood
- Completely natural, contains no chemicals or toxins
- Made in Tunisia


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Using any 3D software
Included in the Physical Special Bundle
The Bundle features 23 collections from Physical Volumes 1 to 5. That's a whopping 2300 high-quality PBR materials ready to be used in your favourite software.
Physical is compatible with nearly all software such as 3DS Max, Maya, Cinema 4D, SketchUp, Blender, Unity, Unreal Engine and many more.
Instant download


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Fleet Manager Responsibilities in a Logistics Company
Fleet managers in logistics companies are responsible for selecting the right vehicles and maintaining them in good operating condition so that the company can meet its distribution objectives efficiently and cost-effectively. They have considerable operational experience in logistics and vehicle maintenance, and use fleet management software to track and monitor the various aspects of fleet and driver operations.
Fleet Manager Trucking Acquisition
Fleet managers make decisions about the types of vehicles to acquire and the most suitable method of financing the fleet. In a small logistics fleet with a few vehicles, they may decide to purchase outright. To preserve cash, they may decide to lease vehicles. At the end of the fleet's operating life, managers aim to get the best possible deal by remarketing purchased vehicles or minimizing final payments and penalties owed to a leasing company.
Logistics: Fleet Manager Job Description
Managers are responsible for registering and licensing each vehicle, and ensuring that licenses are always up to date. They maintain vehicle service and inspection records to ensure compliance with manufacturers' servicing schedules or leasing companies' maintenance requirements. Managers must also maintain records to demonstrate that their fleet operations comply with state laws and the requirements of the U.S. Department of Transportation, the U.S. Occupational Safety and Health Administration, the U.S. Environmental Protection Agency and the International Fuel Tax Agreement.
Fleet Managers and Maintenance
Glassdoor reports that fleet managers are responsible for maintaining the fleet. To maintain vehicles in peak operating condition, fleet managers set up scheduling programs. They may manage an internal parts and service department, or they may appoint an independent service center and parts supplier to handle the work. To minimize downtime, managers negotiate strict servicing time limits and negotiate priority repair schedules with service centers. Regular servicing ensures that vehicles are available for the maximum period to earn revenue and maintain customer delivery schedules. It also helps to reduce costs through greater fuel efficiency.
Fleet Managers and Driver Behavior
According to Boise State University, fleet managers are responsible for supervising staff, in addition to caring for the fleet. Poor driver behavior can influence fleet fuel and maintenance costs. Fleet managers are increasingly taking advantage of telematics systems in vehicles that enable them to continuously monitor aspects of driver behavior, such as speeding, excessive braking and erratic driving. They also use GPS systems to track vehicle locations and improve traceability in the event of a vehicle theft. GPS systems enable managers to monitor vehicle progress and take remedial action in case of serious delays to scheduled deliveries.
Fleet Managers and Cost Control
Fleet managers can use fleet management software to automate the collection and recording of data that enables them to monitor vehicle performance and costs. Managers can analyze the data to identify patterns and take remedial action to reduce costs. Fleet management software also reduces administrative costs by automating the production of drivers' time sheets and records required for regulatory compliance.
Writer Bio
Based in the United Kingdom, Ian Linton has been a professional writer since 1990. His articles on marketing, technology and distance running have appeared in magazines such as "Marketing" and "Runner's World." Linton has also authored more than 20 published books and is a copywriter for global companies. He holds a Bachelor of Arts in history and economics from Bristol University.


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After chemotherapy for breast cancer, one drink of alcohol was about all I could handle. One drink of anything gave me the talkies and made me the happiest person in the room, but any more than one, and I was fried. I discovered this when James and I stopped for a drink at the Fairmont Hotel in San Francisco on our way to the airport.
I ordered a Cosmopolitan, and it was love at first sip.
This was back in the day when Oprah was oohing and aahing about Cosmos, and I wanted to see what all the fuss was about. The bartender and I struck up a conversation and after my first drink he made me a roadie, on the house, and put it in a Styrofoam cup. By the time James and I got to the airport, I'd finished my second Cosmo. When we reached our gate I went to the ladies room, and a few minutes later James said he looked up in time to see a woman, walking down the concourse, who was talking to herself and laughing. A second later he realized that woman was me. In all our years together, he'd never seen me tipsy. It was the first time two drinks had done that to me.
Now my tolerance for alcohol has dropped even further. One drink of anything gives me a hangover the next morning, and I don't get a buzz, so I stopped drinking. When I mentioned this to my doctor, he said it's not uncommon for this to happen to some people as they age. While I never drank to excess, I do miss a great margarita, a glass of champaign, or a vodka tonic, and to some extent, I miss the ritual of having a drink at the end of a long day, but I've found some alternatives.
Over the last year non-alcoholic drinks, better known as mocktails, have surged in popularity. Whether you've stopped drinking alcohol altogether, or you're looking to cutback, there are lots of non-alcohol spirits on the market from distillers like Seedlip, which offer three alternatives to mix with tonic as well as a host of recipes that come with their bottles. FYI, the Seedlip link I've included contains three small sample bottles of each of their premium blends for you to try. Other non-alcohol spirits include Monday Zero Alcohol Gin, and Ritual Zero Proof, a whiskey alternative.
If you like champagne, try a bottle of non-alcoholic champagne and sparkling wine like St Regis Sparkling Brut, Chateau de Fleur, or Surely Sparkling Rosé from Sonoma, California.
Then there are the drinks you can make with your own ingredients like the Mango Mule, Citrus Fizz and the Virgin Cucumber Gimlet, which all sound good, but I haven't made them yet.
Cheers everyone!


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On Thursday 2 July, the Port of Sète and its community are taking a new step towards becoming a smart port of the future.
Following a call for tenders for upgrading its online Port Community System (PCS) launched in November 2019, the Port of Sète selected MGI's Ci5 package for digital goods flow management. The resulting 5-year contract renews the long-term partnership between the Port of Sète and MGI.
This innovative management system upgrade fully aligns with the 2021-2025 strategic project agreed by unanimous vote of the Port Sud de France board, chaired by Jean-Claude Gayssot in December 2019. Ci5's implementation also contributes to the policy led by Carole Delga, President of the Occitanie Pyrénées-Méditerranée Region of strategically focusing on innovation and the challenges of the ecological transition.
A major step in the innovation strategy of southern central France's leading port offering an effective response to the digital and environmental challenges of the future


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Ténor Online filmovi sa prevodom. While working part-time as a food deliveryman, Antoine, an aspiring young rapper from the suburbs of Paris, meets Mrs. Loiseau, an eminent teacher at the Paris Opéra. Stunned by the young man's raw talent, she introduces him to the world of opera. As Antoine becomes one of Mrs. Loiseau's students, he hides his new dream from his friends and family, fearing that they won't understand – this double life burdens him... Somewhere in between the gilded and uptight Parisian upper-class, and the harsh yet free-spirited and familiar suburbs he grew up in, Antoine will have to find his own voice.
Uloge: MB14, Michèle Laroque, Guillaume Duhesme, Marie Oppert, Maëva El Aroussi, Louis de Lavignère, Roberto Alagna, Samir Decazza, Stéphane Debac
Posada: Raphaël Benoliel (Screenplay), Cyrille Droux (Screenplay), Claude Zidi Jr. (Screenplay), Claude Zidi Jr. (Director)
Ključna riječ:
Ténor 2022
Darka Movies
Ténor Ceo Film
Ténor Besplatno online
Ténor Cijeli Film
Ténor Saprevodom
Ténor Filmovizija
Nikada nećemo dijeliti vašu e-poštu ni s kim drugim.
Učitavam ... OK...


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Photo credit: Edward Menashy for Evan Joseph Studio
Actress and comedian Amy Schumer is selling her Upper West Side penthouse at 190 Riverside Drive, the Wall Street Journal reports. Asking $15,000,000, Schumer purchased what she calls her "Manhattan dream apartment" for $12,150,000 in 2016. Surrounded on every side and on the roof above by 3,000 square feet of verdant planted terraces, and centered around a glass-wrapped solarium living room, the five-bedroom, 4,500-square-foot condominium is indeed a New York City dream home–even if it's no longer a secret. Schumer told the Journal she and her husband, chef Chris Fischer, are moving–likely to Brooklyn–to be closer to their son's school.
Step inside Amy Schumer's dreamy sky garden


text: Overview Reviews Product Description The Safe 'n Easy product line of non-drip lemon citrus paint removers provides DIY- end users with easy to use water-based, non-toxic gel products in a variety of pleasant scents to strip paint around the home, office or business. Product Videos Custom Field Product Reviews Write a Review Write a Review × Dumond Dumond 3532 qt Safe 'n Easy Lemon Citrus Paint & Varnish Remover Gel - 6ct. case Rating * Select Rating 1 star (worst) 2 stars 3 stars (average) 4 stars 5 stars (best) Name Email * Review Subject * Comments *


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In looking back, I am understanding how the requirement to be my own best friend has always lead me into internal conversations.
One great thing about human relationships is that we can spread the ambiguity and ambivalence. The final answer might be patchwork and rough, but at least in the conversations we have leading up to that point we get to take pure and perfect positions, arguing for this factor or that, fighting out a compromise outside ourselves.
For example, a family may have to choose if they want to attend an event or not. Their process of making that decision is externalized. It may be true that it is both an obligation and there are preferable things to do, but when one person takes one position and another takes another, it works to process.
For an introvert dealing with stigma who lives an internalized life, well, it's not that simple. Analysis paralysis is easy.
The therapist I saw in the 1980s noticed. "I have people come in all the time telling me that, for example, 'My boss is an idiot,'" he told me. "But you come in and tell me that, and then tell me "but the reason he is making those choices is because. . .' You take their position, work to understand, have compassion. That's different."
Other people see that. One commenter on this blog offered "I feel a certain hope that your compassion is going to get you past these things…"
But that compassion is very much part of my internalized conversations, that requirement to puzzle things out inside by taking multiple positions to find some kind of center.
Recently, for example, I know I have lost that balance, falling too far onto the cynical & sad side. In the past when this happened, I would often find myself writing a letter to me, reminding me of hope & possibility, of the good things lost in the mess.
I take these internal conversations as normal now, unremarkable. It just happens. The first time I met Virginia Prince, she thought I wasn't embracing my femme side. I wondered which femme side she was talking about; my Jonathan Winters energy always ended up with lots of voices bouncing around in my head.
I guess I can't imagine how you can possibly save yourself until and unless you can listen to many parts of you, the many points of view that are required to describe a complex world and a nuanced worldview. I know that I can no more see my own heart than I can see the back of my own head; I can only see the choices I make (or want to make) and learn from those choices.
I have seen lots of therapeutic techniques designed to foster this kind of inner conversation, down to watching someone hop between chairs labeled with points of view in a demonstration at IFGE Portland 1994. Many have figured out that to live the examined life we have to be willing to examine our own inner voices.
I know that some believe I have taken this a bit far, adopting a number of posting personae over the years. But this has been useful to me, speaking in another voice and seeing what comes out. The process of becoming someone else to understand them has always served me well, as it has many shamans and femmes through the centuries. When Ms. Rachelle tells me she finds my written conversations good because she can easily tell the difference in voice and point of view, I know I have succeeded. In fact, hidden on this blog is a very long series of conversations between me and a therapist also played by me, conversations that came out of some very, very tough times.
I know that my own inner conversations have been key to my own self-discovery and actualization. I have let the facets speak, and they have helped me map my own inner landscape.
For me, I don't know how I would survive without a thriving inner conversation, a talk show in my head.
But maybe tha't's just me.


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Mumbai: Haj Committee of India, the apex body responsible for Hajj operations in India, has decided on Monday to extend the last date of submission of online and manual haj application forms till February 15, 2016.
The decision is taken after requests were made to Central Haj Committee by several State Haj Committees, and other Muslim groups and individuals.
"In view of the representations received from several State Haj Committees, the last date of submission of Haj Application Forms - both online and manual, is hereby extended by a week's time i.e. upto February 15, 2016", the Haj Committee of India announced on its official website.
The Haj Committee of India had initially fixed the closing date of rceiving the Haj Application Forms as Februray 08, 2016.
"Consequently, applicants possessing international passports issued on or before February 15, 2016 and valid at least upto March 10, 2017 will be eligible to apply for Haj 2016", the official announcement said.
Booklets containing Guidelines and Haj Application Forms (HAF) can be downloaded from the Haj Committee of India website: www.hajcommittee.gov.in.
The Haj Committee of India also said that the distribution of state-wise quota this year will be based on 2011 census. Till 2015, the quota distribution was done as per the 2001 census. The Hajj Committee of India decides total number of hajis going for hajj from different Indian states based on the population of Muslims.
Meanwhile, more than 350,000 Muslims from all across India have applied for the Haj 2016 till Saturday February 06, 2016. Maharashtra alone has received applications four times more than its quota.
A total of 150,000 Muslims got to Haj from India. Out of them about 130,000 pilgrims go through the Haj Committee of India. Remaining pilgrims opt for Private Tour Operators (PTOs) to perform the annual ritual.
Muslims from across the world gather in Makkah, Saudi Arbia once in a year in the month of Dhul Hijja to perform Hajj.


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Upgrade the classics with Converse Chuck Taylor All Star Things To Grow black high top shoes! Featuring what you know and love about the All Star, such as the reinforced rubber toe cap, the high top silhouette, and rubber Chuck Taylor logo on the inner ankle. In contrast to the black colorway, embroidered along the upper and inner ankle canvas are graphics of several flower variants, lending them a blossoming of color.
Product Details:
Size & Fit:


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Virtual OSU All Majors Career Fair
Virtual OSU All Majors Career Fair
Thursday, March 3 | 10 a.m.-5 p.m. | Virtual - Career Fair Plus
Looking for a full-time job after graduation or a summer internship? Don't wait - now is the time when employers are hiring! The Virtual OSU Career Fair is the ideal place to learn about job opportunities, meet industry professionals, and practice your networking skills.
But wait, how do you "do" a virtual career fair?
We've put together an entire Virtual Career Fair Prep Portal just for students and alumni that includes info on setting up your profile, discovering employers coming to the virtual fair, and scheduling one-on-one video appointments. Basically, everything you need to know to "do" a virtual career fair.
OSU-Tulsa Career Services offers events to help students with their job search. All events are free for current students unless specified. Students must activate their account through HIREOSUGRADS.COM in order to register for many events.


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"The View" welcomed Democratic presidential candidate Bernie Sanders to the show on Wednesday where co-host Meghan McCain pressed him on bipartisanship.
Sanders began by describing Donald Trump as the most dangerous president in U.S. history, but McCain interrupted to ask him if he was willing to work with Republicans in Congress.
"I'm generally curious about bipartisanship," she said. "Can you name any?"
Sanders quickly suggested Sen. Johnny Isakson (R-GA), who recently announced his retirement from Congress due to health reasons, but McCain was unsatisfied.
"He's retiring," she said.
"Your dad was somebody I worked with," Sanders said.
"But they're dead or now not serving anymore," McCain said.
"Johnny is not dead," Sanders pointed out.
"I know," McCain said, "but he's leaving, he's retiring."
"Look," Sanders sighed. "Even somebody like a George W. Bush, who was a very conservative guy."
But an unsatisfied McCain continued to press Sanders on whether he can work with any Republicans who are currently serving in Congress if he was elected president.
"Lamar Alexander," Sanders said. "He is head of the committee that I'm on. He's a conservative Republican."
Sanders explained to McCain why Alexander stood out from other Republicans, and the fundamental obstacles they placed before bipartisan cooperation.
"He's not a liar, a sexist, a racist or a homophobe," Sanders said, as McCain glared at him. "I worked with your dad on issues where we think people can come together. That's what politics is supposed to be about, and we have a president today, and it gives me no joy to say this. He's a pathological liar, and when people ask me, what do you think about Trump said five minutes ago in a tweet? I'm not going to say anything because 10 minutes from now, he's going to change his view, and I can't comment."
Take a look at the discussion in the video clip below:
RELATED: Morning Joe Utterly Destroys 'Moscow' Mitch McConnell For Siding With Putin And Domestic Terrorism


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July is for the ladies of the house
This female House Finch (Haemorhous mexicanus) is The Green Ogre July wallpaper. Download and share the love Continue reading July is for the ladies of the house
This female House Finch (Haemorhous mexicanus) is The Green Ogre July wallpaper. Download and share the love Continue reading July is for the ladies of the house
Celebrate June rains with this Green Ogre calendar wallpaper for desktops, ipads and laptops. Download it for free Continue reading Celebrate June rains with this wallpaper
May is here. How about killing time with this wallpaper of an Assassin Fly or Robber Fly? Continue reading May Wallpaper – Kill time with this Assassin Fly
This gorgeous lady in red is all set to make April shine on your desktop, laptop and iPad screens. Go ahead, pick a size. Continue reading April is here, and she's a lady in red
The first pleasant days of spring come out like a squirrel and go in again, wrote Thoreau. Download and put up this wallpaper to make spring last! Continue reading This March, put Spring in your step
At Walton Lighthouse, a warmth no blanket could provide slowly spreads all over, and I realise it is from within. Download this December wallpaper by Sandeep Somasekharan for The Green Ogre Continue reading Warmth in December – Download and share
Our November wallpaper comes to you, born of a moment of peace at Natural Bridges beach, Santa Cruz, CA. Download. Enjoy. Share. Continue reading Peace prevails in November: Download the wallpaper
This October, we offer you an image to inspire your travels into the wilderness. The road. Yes, the open road. Happy trails! Continue reading It's October, let's hit the road
August leaves us with grey skies that ache for colour. Luckily, here's a House Finch that will brighten up your August days. Download and share this wallpaper Continue reading August needs a splash of red
A damselfly in the sun, this Rusty Marsh Dart (Ceriagrion olivaceum), flecked with morning dew awaits the day's warmth to dry itself. Continue reading Will July save this damsel(fly) in distress?


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Samsung is preparing for the launch of the new generation of its most popular connected watch: the Samsung Galaxy Watch 4. The most important novelty that this fourth generation will incorporate will be the complete renovation of its interface, which will change from the famous Tizen. to the new and confirmed One UI Watch, software that hides Wear OS under its guise.
Now, from SamMobile, we have been able to see the final appearance of this new interface, incorporating not only changes in the installation of the application, but also new exclusive spheres depending on the version chosen, i.e. the finish. Classic, or the standard finish. .
Samsung's own apps that make room for the Play Store
In detail, this overhaul of Samsung's personalization layer for its connected watches will be based on a new application drawer in hexagonal format from which we will be able to easily access the various applications that we have installed.
Here's a little Galaxy Watch 4 tease, thanks to our tipster! pic.twitter.com/7sMP41WU7b
– SamMobile (@SamMobiles) July 27, 2021
In these videos shared by SamMobile, we can appreciate the presence of the Play Store, one of the great advantages of the South Korean company's agreement with Google. But we won't only be able to enjoy the apps downloadable from this repository, as we can appreciate how Samsung would keep some of its own dedicated apps like Samsung Health or Bixby, so that proprietary services continue to be one of the stones. Angular interface.
Another interesting detail is that, according to this leak, we will have specific dials for each version of the watch, having a slightly more serious and elegant aesthetic for the Galaxy Watch4 Classic and tilting the standard version towards a much more casual design.
Samsung Galaxy Watch 4
In principle, the new Samsung Galaxy Watch 4 is expected to be unveiled at the Samsung Unpacked on August 11 along with other devices from the South Korean firm. Previously, other leaks have revealed their price and release date, but we will have to be patient to confirm all this information that we may know soon.
Origin | Sammobile


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Samsung SM-N910V Galaxy Note 4 Verizon/Unlocked Smartphone GOOD (White). Don't forget to sign up for our newsletter.
Description: Samsung SM-N910V Galaxy Note 4 Smartphone for Verizon network. You can insert an active SIM card from any GSM network like AT&T, T-Mobile, etc. Note that when using GSM network, the internet speed (if you have a data plan) may not be as fast as that of the original CDMA network. This top-end, large-screen Android sports a unique touch-screen that bends around the right side.
Other features include a heart rate monitor, infrared port, large removable battery, memory card slot, and global roaming. Cosmetic Condition: GOOD (see details below).
Even though we try our best to take the shots, some item's flaws may not be visible in the photos. Buyers should refer to the condition details table for more information. This table is for reference only. The condition of this item is specified above. GOOD: (7-9 out of 10) Light previous usage with few minor marks.AVERAGE: (5-6 out of 10) Normal previous usage with some marks or scratches on the housing and/or display screen; no cracks. HEAVILY USED / POOR: (3-4 out of 10) Heavy wear with significant scratches and/or marks, but is still fully functional. The cosmetic condition, however, does not affect the functions. It suits those who care more about functionality than look. You can still return an unwanted item after receiving it.
Feedback We strive for 5 star ratings. We will try our best to rectify any problem to make sure you are 100% satisfied. Powered by SixBit's eCommerce Solution. This item is in the category "Cell Phones & Accessories\Cell Phones & Smartphones". The seller is "cellularoid" and is located in this country: US.
This item can be shipped to United States, Canada.


text:
Yield: 1 Servings
|1 medium
|Onion, minced
|1 medium
|Carrot, scraped and chopped
|1 medium
|Red bell pepper, chopped
|1 medium
|Yellow bell pepper, chopped
|Jalapeno peppers, seeded and minced (up to 6)
|3 tablespoons
|Butter, melted
|3 tablespoons
|3 cups
|Chicken broth (or beef broth ?)
|2 cups
|Heavy whipping cream
|1 cup
|Shredded Cheddar cheese
Cook first 5 ingredients in butter in a large saucepan over medium high heat until vegetables are tender, stirring often. Reduce heat to low. Add flour, stirring until blended. Cook 1 minute, stirring constantly.
Gradually add broth; bring to a boil. Reduce heat to medium, simmer uncovered for 5 minutes. Stir in cream; cook just until thoroughly heated (do not boil). Add cheese, cook, stirring constantly, just until cheese melts. Makes about 7 cups.
Posted to CHILE-HEADS DIGEST V3 #129 Date: Fri, 11 Oct 1996 11:18:46 +0100 From: gcaselton@... (Graeme Caselton BSc(Open))