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International Journal of Chemical and Biomolecular Science
, Vol.4, No.4, Dec. 2018, Pub. Date: Dec. 21, 2018
Effect of Storage on the Bioactivity of Drepanoalpha
(An Anti-Sickle Cell Disease Polyherbal Formula) and Comparative Biochemical Profile of Different Batches
Pages: 60-68
Koto-te-Nyiwa Ngbolua, Department of Biology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo; Department of Biomedical Sciences, University of Gbadolite, Gbadolite, Democratic Republic of the Congo.
Benjamin Zoawe Gbolo, Department of Biology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Joseph Dipa Tshidibi, Department of Biology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Damien Sha Tshibey Tshibangu, Department of Chemistry, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Patrick Bondo Memvanga, Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Pius Tshimankinda Mpiana, Department of Chemistry, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
is a poly-herbal formula (PHF) used in Democratic Republic of the Congo for the management of Sickle Cell Disease (SCD), a genetic disease due to the presence of hemoglobin S in the blood which could in hypoxia conduct to the formation of tactoids, the leading cause of erythrocyte sickling that plays a key role in the pathophysiology of SCD like vaso-occlusion (due to the loss of membrane elasticity) and hemolytic anemia. The aim of the present study was to evaluate the storage time effect on the bioactivity and the secondary metabolites (anthocyanis and flavonoids) and minerals (Fe, Mn, Zn and Cu) profiles of this PHF. Results revealed that flavonoids content of different batches is of the same order of magnitude: the percentage of ratio flavonoids/total polyphenols was 5.3% (batch A); 5.0% (batch B); 4.7% (batch C). However, the anthocyanins content of PHF varies according to the storage time. The percentage of ratio anthocyanis/total polyphenols was 3, 2% for batch A; 4, 7% for batch B; 8, 3% for batch C. Results revealed no significant difference between the average values of total ash (11.34 ± 0.35 84 g/100 g DM for A; 11.5 ± 0.12 84 g/100 g DM for B and 10 ± 0.84 84 g/100 g DM for C) of three batches (threshold: 5%). The different batches of Drepanoalpha
contain Fe (0.535± 0.107 mg/100 g for A; 0.517 ± 0.103 mg/100 g for B; 0.54 ± 0.108 mg/100 g for C), Mn (4.366 ± 0.786 mg/100 g for A; 4.7 ± 0.799 mg/100 g for B; 4.318 ± 0.734 mg/100 g for C), and Zn (2.293 ± 0.321 mg/100 g for A; 2.389 ± 0.334 mg/100 g for B; 2.338 ± 0.327 mg/100 g for C) and are free of Cu. The micronutrient values of batches A, B and C are not significantly different (threshold: 5%) from each other. At 250 μg /mL, there is no significant difference (threshold: 5%) in anti-oxidative activity between the different batches. All samples displayed strong anti-sickling activity indicating thus at room temperature, the storage time (one or two years) has no effect on the bioactivity, flavonoids content and mineral profile of the PHF. It is desirable that Drepanoalpha
could be formulated as syrup or capsule for a double blind, placebo-controlled and randomized cross-over clinical trials in SCD patients.
Sickle Cell Disease, Traditional Medicine, Medicinal Foods, Anti-sickling Activity, Polyphenols
Girot R, Bégué P, Galacteros F. La drépanocytose. John Libbey Eurotext Paris, 2003.
Bardakjian MJ, Dhont JL, Du Crocq R. Bonnes pratiques de l'étude de l'hémoglobine Ann. Biol. Clin. 2003; 61: 401-09.
Mpiana PT, Ngbolua KN, Atibu EK, Kasonga TM, Bokota MT, Mudogo V. In vitro effects of anthocyanins extracts from Justicia secunda Vahl on the solubility of hemoglobin S and membrane stability of sickle erythrocytes. Blood Transfusion. 2010; 8 (4): 248-54.
Mpiana PT, Mudogo V, Tshibangu DST, Kitwa EK, Kanangila AB, Lumbu JBS, Ngbolua KN, Atibu EK, Kakule MK. Antisickling activity of anthocyanins from Bombax pentadrum, Ficus capensis and Ziziphus mucronata: Photodegradation effect. J. Ethnopharmacology. 2008; 120: 413-418.
Mpiana PT, Makelele LK, Oleko RW, Bokota MT, Tshibangu DST, Ngbolua KN, Mbala MB, Atibu EK, Nsimba SM. Antisickling activity of medicinal plants used in the management of Sickle cell Disease in Tshopo District, D. R. Congo, Australian Journal of Medical Herbalism. 2010; 22 (4): 132-137.
Ngbolua KN, Mpiana PT, Tshibangu DST, Gbolo BZ. Bioactivity of medicinal plants traditionally used for the management of sickle cell disease in Democratic Republic of the Congo: State of the art and future directions in: Sickle cell disease: Genetics, management and prognosis. New York. Nova Science Publishers, 2015.
De Montalembert M, Tshilolo L. Les progrès thérapeutiques dans la prise en charge.de la drépanocytose sont-ils applicables en Afrique subsaharienne. Med. Trop. 2007; 67: 612-616.
Ngbolua KN, Mpiana PT, Akoundze BJ, Mwanza BF, Tshibangu DST, Masengo AC, Liesse JM, Takaisi K. Anti-sickling and bacterial inhibitory effects of two medicinal foods from the Congo River basin: Gnetum africanum Welw. (Gnetaceae) and Grewia coriacea Mast. (Malvaceae). Current Traditional Medicine. 2016; 2 (1): 34-41.
Mpiana PT, Ngbolua KN, Tshibangu DST. Les Alicaments et la drepanocytose: Une mini revue. Comptes Rendus Chimie. 2016; 1 (6): 884-89. French.
Tshilanda DD, Onyamboko DNV, Babady BP, Mutwale KP, Tsalu VP, Tshibangu DST, Ngombe KN, Ngbolua KN, Mpiana PT. Chemical fingerprint and anti-sickling activity of Rosmarinic acid and Methanolic extracts from three Species of Ocimum from DR Congo. Journal of Biosciences and Medicines. 2016; 4: 59-68. http://dx.doi.org/10.4236/jbm.2016.41008
Ngbolua KN, Rafatro H, Rakotoarimanana H, Mudogo V, Mpiana PT, Tshibangu DST, Tshilanda DD. In vitro anti-erythrocyte sickling effect of lunularic acid of natural origin. International Blood Research & Reviews 4 (3): 1-6, 2015.
Tshibangu DST, Shode FO, Koorbanally N, Mudogo V, Mpiana PT, Ngbolua KN. Antisickling triterpenoids from Callistemon viminalis, Meulaleuca bracteata var. Revolution Gold, Syzygium guineense and Syzygium cordatum. The 14th NAPRECA Symposium and AAMPS Ethnoverterinary Medicine Symposium 8th-12th August, 2011. International Centre for Insect Physiology and Ecology (ICIPE): Kasarani, Nairobi, Kenya, pp. 296-300 (YS 27).
Tshilanda DD, Onyamboko DNV, Babady PB, Ngbolua KN, Tshibangu DST, Dibwe EF, Mpiana PT. Anti-sickling Activity of Ursolic Acid Isolated from the Leaves of Ocimum gratissimum L. (Lamiaceae). Nat. Prod. Bioprospect. 2015; 5: 215-221. doi 10.1007/s13659-015-0070-6.
Ngbolua KN, Mpiana PT, Tshibangu DST, Mazasa PP, Gbolo BZ, Atibu EK, Kadima JN and Kasali FM. In vitro antisickling and radical scavenging activities of a poly-herbal formula (Drepanoalpha
) in sickle cell eruthrocyte and acute toxicity study in Wistar albinos rats. European Journal of Medicinal Plants. 2014; 4 (10): 1251-67.
Ngbolua KN, Mpiana PT. The possible role of a congolese polyherbal formula (Drepanoalpha
) as source of epigenetic modulators in sickle cell disease: A hypothesis. J. of Advancement in Medical and Life Sciences. 2014; 2 (1): 1-3.
Mpiana PT, Kasali FM, Bwirhonde F, Gbolo BZ, Tshibangu DST, Ngbolua KN, et al. Acute and sub-acute oral toxicity studies of Drepanoalpha
(a poly-herbal formula used in the management of sickle cell disease) in guinea-pig. British Journal of Pharmaceutical Research. 2016; 10 (5): 1-8.
Ngbolua KN, Tshidibi JD, Tshibangu DST, Memvanga PB, Gbolo BZ, Tshilanda DD, Mpiana PT. Drepanoalpha
: An Overview on the Quality Control Process and Standardization Feature of an Antisickling Herbal Drug from Democratic Republic of the Congo. J. of Modern Drug Discovery and Drug Delivery Research. 2016; V4I1. DOI: 10.15297/JMDDR.V4I1.01.
Gbolo BZ, Asamboa LS, Bongo GN, Tshibangu DST, Kasali FM, Memvanga PB, et al. Bioactivity and chemical analysis of Drepanoalpha: An anti-sickle cell anemia poly-herbal formula from Congo-Kinshasa American Journal of Phytomedicine and Clinical Theurapetics. 2017; 5 (1): 1-5.
Gbolo BZ, Tshibangu DST, Asamboa LT, Bongo NG, Kasali MF, Feza BV, Ngbolua KN, Mpiana PT. Sickle cell anemia therapeutic approach based on Drepanoalpha
: About 34 cases. Journal of Complementary and Alternative Medical Research 2017; 4 (2): 1-8.
Ngbolua KN, Tshilanda DD, Djolu RD, Falanga MC, Masengo AC, Tshibangu DST, Iteku BJ, Mudogo V, Mpiana PT. Anti-Sickle Cell Anemia and Bacterial Inhibitory Effects of Uvariodendron molundense (Diels) R. E. Fr. (Annonaceae) from Ubangi River Basin, DR Congo. Journal of Biosciences and Medicines. 2017; 5: 71-84.
Tshibangu DST, Ngbolua KN, Lengbiye EM, Tshilanda DD, Mvingu KB, Iteku BJ, Mbala MB, Mudogo V, Mpiana PT. Chemical composition and bioactivity of Canarium schweinfurthii stem bark extracts from DR Congo against Sickle cell disease and associated bacteria. Journal of Pharmacognosy and Phytochemistry. 2016; 5 (4): 181-187.
Giusti MM, Wrolstad RE. Characterization and measurement of anthocyanins by UV-visible spectroscopy. In Current Protocols in Food Analytical Chemistry; Wrolstad, R. E., Ed.; John Wiley & Sons: New York, NY, USA, pp. 7–47, 2001.
Ruch RJ, Cheng S-J, Klaunig JE. Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from chinese green tea. Carcinogenesis. 1989; 10 (6): 1003-1008.
Prieto P, Pineda M, Aguillar M. Spectrophotometric quantitation of antioxidant capacity through the formation of phosphomolybdenum complex: specific application to determination of vitamin E. Anal Biochem. 1999; 269: 337-341.
Laurent L. Eléments minéraux. In: Techniques d'analyses et de contrôle dans les industries agroalimentaires. Volume 4. Lavoisier (Ed). Paris, 1999.
Mbemba F. Aliments et denrées alimentaires traditionnels du Bandundu en RD Congo: Répertoire et composition en nutriments, Ed L'Harmattan, Paris, 2013.
Prasad AS. Clinical, Immunological, Anti-inflammatory and Antioxidant roles of Zinc. Exp Gerentology. 2008; 45 (5): 370-377.
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Friday, November 14, 2008
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Mitchell Turner ready for racquetball national team
When Mitchell Turner saw his sister playing racquetball at Sprague High School for the first time four years ago, he was in awe.
An avid soccer player, Mitchell was amazed by the pace and rhythm of the sport. He was so impressed with the game he wanted to get on the courts and start playing as soon as possible.
"My sister actually started playing in high school for the Sprague team (and) I liked it and stopped playing soccer," Turner said. "I was looking for a new sport I guess."
Turner quickly caught on and began playing at local and state tournaments. As his skills improved and he started winning consistently, he began working with a professional coach out of Seattle, Fran Davis, who works with the top-ranked U.S. women's player and the second-ranked U.S. men's player.
"We started taking him down and got him outfitted and it went from there," Mitchell's mom, Frances Turner said. "He's always been very quick at everything that he's tried."
Even though he was a quick study, Turner said that in order to improve his game he played five-to-six days a week and it took "quite a bit of work (and) a lot of long hours putting in a lot of practice."
In late June, Turner entered the boys 14-and-under singles and doubles tournaments at the 2015 U.S. National Junior Olympics Championships in Stockton, California. It was the first time he and his partner, Julian Singh (Pleasanton, California), played together as doubles partners.
Turner finished fourth in singles and won the doubles national championship with Singh, earning them a spot on the US Junior National team.
"I contacted him looking for a partner to play with and I hadn't really known many people that played (doubles)," Mitchell Turner said. "I had met (him) a few times at nationals so I figured I would call him up and (ask) to play with him."
Mitchell admitted that he hadn't played much doubles in the past, but that he really started practicing doubles leading up to nationals.
"We got there and we played pretty well together," Turner said. "We'd never played together before. Most of the people that have played all know each other and they've played quite a bit with each other."
Turner will be heading to an Olympic Training camp next week in Colorado Springs, Colorado, to meet his teammates and get some practice in before the Junior World Championships in Santo Domingo, Dominican Republic in November.
He hopes to regain some of that magic that Julian and he had while winning the U.S. doubles championship.
"Doubles is a tough division, he had to win four or five matches," U.S. Junior National Team coach, Cheryl Gudinas said. "Bolivia and Mexico are tough so when we get to worlds, those will be our top two countries that we have to worry about. I think they can definitely win it, (but) making the semis or the finals even would be a great accomplishment because the other countries are so tough."
Gudinas has had an opportunity to watch Turner play and came away impressed with his skills and his ability to grow and move up through the national team.
"He's got a great game, I feel like he's definitely going to be somebody that's going to be on the team for a long time to come now that he's made it," Gudinas said. "Consistency and the experience of going to his first worlds as a team member is going to be good. That's always what these younger players need is the experience and getting out there (as well as) operating under pressure."
Turner will finance his whole trip to the Dominican Republic for the Junior World Championships, but is seeking donations to help him offset the cost. The family has set up a go fund me account at http://de.gofund.me/z6gu4mg8.
email@example.com or Twitter.com/@LuisRamirez10


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home of the original Thai sandwich
Woke up
with a cup of water
Buy her a Delorean


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Some companies do not understand the importance of a podcast, but customers like to hear them for their educational value. In today's society, there are numerous podcasts that people can choose from. Podcasts are an excellent way to reach consumers that might be ready to purchase a product or service and additional information. By listening to a podcast for educational information regarding a brand, a customer is likely to buy from a brand instead of an advertisement. Adding a podcast to your business is a great way to grow sales and increase brand awareness.
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Remember, like any marketing plan, your initial podcast strategy may need to be tested, modified, analyzed, and updated as you move forward. This is particularly important for someone that is launching a new podcast. Before adopting new or additional strategies, ensure that you are maximizing your current opportunity and increase awareness.


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Disabling Perversions
The book offers an overview of how to work with some of the most damaged members of society - children and adults with intellectual disabilities who abuse others. Drawing on insight from two decades of clinical work, the author examines how to assess risk and danger in the forensic disability patient, ways of working therapeutically with patients at all ends of the disability spectrum, and how to support members of the patient's network. Combining psychoanalytic, creative, forensic and systemic thinking, the book provides a template for assessing, managing, containing and treating those who present with multiple diagnoses, including cognitive and physical disabilities, mutism, psychiatric disorders and autism. Both group and individual approaches are examined. As our awareness of the incidence of forensic patients who also have disabilities increases, this work is a timely placing of the forensic disability patient onto the clinical agenda, and has a wide application, being of use to clinicians in the private consulting room, the community, the secure setting and the prison.
- Copyright:
- 2014 Routledge
Book Details
- Book Quality:
- 9780429912795
- Publisher:
- Taylor and Francis
- Date of Addition:
- Language:
- English
- Categories:
- Nonfiction, Psychology,
- Usage Restrictions:
- This is a copyrighted book.
Choosing a Book Format
EPUB is the standard publishing format used by many e-book readers including iBooks, Easy Reader, VoiceDream Reader, etc. This is the most popular and widely used format.
DAISY format is used by GoRead, Read2Go and most Kurzweil devices.
Audio (MP3) format is used by audio only devices, such as iPod.
Braille format is used by Braille output devices.
DAISY Audio format works on DAISY compatible players such as Victor Reader Stream.
Accessible Word format can be unzipped and opened in any tool that supports .docx files.


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Crain's Quick 50: Mortgages, development fill fastest-growing firms
The mortgage enterprise hit a dizzying peak in 2021. And Crain's Quick 50 listing of fastest-growing companies displays that.
One-two on the listing are metro Detroit's mortgage giants, Rocket Firms and UWM Holdings. Another financial-services firms on the listing, together with Flagstar Bancorp, additionally specialise in mortgages.
However that is not the one enterprise that is boomed.
Maybe most hanging is the variety of development firms on this 12 months's listing — seven of the 50. They have been helped by business funding, not least with regards to the automotive business's huge funding in crops to provide electrical autos.
A phrase on how we calculate this listing, which in some methods differs from comparable lists that look purely at a proportion income improve:
Our listing takes that under consideration, however we additionally rank the businesses for which we have now information by the greenback quantity of their income improve. It's because in our estimation, scale issues, and driving massive gross sales will increase at a big, established firm isn't any straightforward feat.
So we rank every of the businesses for which we have now information from 2018 to 2021 on their proportion income improve, in addition to rating them on the greenback improve. We add up these rankings to provide the ultimate listing. Firms that do nicely on each scales do finest.
Profitability issues, too. We ask every firm to attest that it has been worthwhile, as a result of driving up income is straightforward when you're promoting at a loss.
So, with out additional ado:


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© Chemieanlagenbau Chemnitz GmbH
On 16 December 2010 the 2nd stage of the Haidach underground gas storage facility has been handed over by Chemieanlagenbau Chemnitz GmbH (CAC) to the consortium of RAG / WINGAS / GAZPROM export.
The plant was erected and commissioned on time schedule.
Besides additional storage wells the extension of the Haidach facilities includes two additional compressor units as well as two additional gas drying units with all required auxiliary units.
Main attention was paid to a high flexibility of the whole plant.
The 2nd stage of extension was implemented under full operation of the existing units.
The mechanical completion of the Haidach underground storage facility was achieved at the end of 2010. From 01 April 2011, the facility - with its working gas volume of 2.64 billion Nm³ - will play a central role in the supply of gas to Austria and Europe.
Ukraine Kazakstan Chile


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Tag: scotland
Behind the Instagram #2
I posted this image on Instagram on the evening of June 24, 2018 while in Newtonhill, Scotland. The next morning I accidentally dated my journal September 25, 2018. With a few edits for clarity, here's what I wrote: The North Sea, the great expanse of water horizon. On days when the break between water and […]


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Web info is a vital resource which can be used to improve a website or app's performance. Businesses can use this kind of data for any variety of usages, including market research, to understand consumer behavior and gauge the healthiness of a website or perhaps app. Top quality web datasets are on a regular basis updated and will support businesses accumulate key demographic and behavioral information with regard to their marketing campaigns. This data is certainly collected by simply websites and other sources. Moreover to allowing better marketing plans, web data could also be used to assess a great app's overall health.
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Net data can help businesses monitor how many people go to a website or perhaps app and exactly how long that they stay on the website. It also will help companies know how they can enhance their advertising campaigns. Some companies might track how much time people remain on their website or perhaps application, and whether they purchase a product. These kinds of data will help them make better decisions about which usually products and services to provide to their clients. If you want to work with web info, the best way to get it is to use an internet scraping services.


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Book of Mormon for Children
Mormon: Mormon and the Book of Mormon [offsite link]
Friend, May 1984, page 34. A simple telling of Mormon by Mark E. Petersen.
Moroni (a retelling) [offsite link]
A retelling of Moroni (son of Mormon) by Mable Jones Gabbot. From the Friend,Feb. 1971, 21
Nephi Builds a Ship [offsite link]
This sharing time can be adapted for Family Home Evening or homeschooling. It includes line drawings for a flannel board story.
Links marked with the [offsite link] designation point to websites not associated with BellaOnline.com. BellaOnline.com is not responsible for the material found there.
Editor's Picks Articles
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Content copyright © 2018 by . All rights reserved.
This content was written by . If you wish to use this content in any manner, you need written permission. Contact Jamie Rose for details.


text:
Join our photo community by becoming a Member and help our non-profit grow!
Registration is easy. Just select your desired support level below and subscribe.
Where Does Your Money Go?
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Closed Bug 478845 Opened 14 years ago Closed 14 years ago
Disable mochitest of test plugin if test plugin is not built
(Core Graveyard :: Plug-ins, defect)
(Not tracked)
(Reporter: ginnchen+exoracle, Assigned: ginnchen+exoracle)
(1 file, 4 obsolete files)
7.84 KB, patch
Waldo: review+
|Details | Diff | Splinter Review
14 years ago
This is a follow-up of bug 471759. Test plugin is not built for port platforms. We should also disable the mochitest of test plugin. I found test plugin works fine on Solaris. So I enabled it on Solaris.
Assignee: nobody → ginn.chen
Status: NEW → ASSIGNED
Attachment #362689 - Flags: review?(joshmoz)
I meant this is a follow-up of bug 474503.
Attachment #362689 - Flags: review?(joshmoz) → review?(roc)
Ted, can you come up with a scalable solution here? We don't want to sprinkle this architcture-test macro all over the place because we'll forget to update it if we add a supported test plugin platform.
Comment 4•
14 years ago
My thought was to add a function to the test harness like haveTestPlugin(), so you could do something like: if (!haveTestPlugin()) { todo(false, "Need a test plugin on this platform"); } else { // run some tests... } haveTestPlugin() could basically reuse the code I wrote for reftest: http://mxr.mozilla.org/mozilla-central/source/layout/tools/reftest/reftest.js#241
OK, Ginn, can you add that to SimpleTest.js and the tests? Thanks!
Attachment #362689 - Flags: review?(roc)
Attachment #362689 - Attachment is obsolete: true
Attachment #363286 - Flags: review?(ted.mielczarek)
Comment 8•
14 years ago
I don't see why, I think my version is just as good (and doesn't require UniversalXPConnect privileges).
I just thought it would be easier to reuse the code in test_bug391728.html, if there's no functional difference. Should I copy "haveTestPlugin" to test_bug391728.html or somewhere else? I think I don't need "enabledPlugin != null" for test_bug391728.html, right?
Comment 10•
14 years ago
Ted, I found the difference of "haveTestPlugin" and "get_test_plugin". If the test plugin is disabled, "haveTestPlugin" will not see the plugin, "get_test_plugin" still returns the plugin. Since we're testing plugin.disabled later in this file, I think "get_test_plugin" more appropriate here.
Comment 11•
14 years ago
Ok, that sounds reasonable. We should put this function in a common Mochitest file. Waldo: where are we keeping utility functions like this in Mochitest?
Comment 12•
14 years ago
EventUtils and WindowSnapshot both make the case for somewhere in testing/mochitest/tests/SimpleTest/, in a standalone file as this wouldn't need to hook into the test-execution sequence.
Comment 13•
14 years ago
Comment on attachment 363286 [details] [diff] [review] patch v2 r- because I'd like to see this function move to the mochitest harness. Please r? jwalden if you write a patch to do that.
Attachment #363286 - Flags: review?(ted.mielczarek) → review-
Comment 14•
14 years ago
Attachment #363286 - Attachment is obsolete: true
Attachment #364052 - Flags: review?(jwalden+bmo)
Comment 15•
14 years ago
Comment on attachment 364052 [details] [diff] [review] patch v3 >diff --git a/testing/mochitest/tests/SimpleTest/plugin.js b/testing/mochitest/tests/SimpleTest/plugin.js >+function get_test_plugin() { >+ var ph = Components.classes["@mozilla.org/plugin/host;1"] >+ .getService(Components.interfaces.nsIPluginHost); >+ var tags = ph.getPluginTags({}); >+ >+ // Find the test plugin >+ for (var i = 0; i < tags.length; i++) { >+ if (tags[i].name == "Test Plug-in") >+ return tags[i]; >+ } >+} An alternative strawman API: var PluginUtils = { withTestPlugin: function(callback) { if (!("Components" in this)) { todo(false, "not a Mozilla-based browser"); return; } var ph = Components.classes["@mozilla.org/plugin/host;1"] .getService(Components.interfaces.nsIPluginHost); var tags = ph.getPluginTags({}); // Find the test plugin for (var i = 0; i < tags.length; i++) { if (tags[i].name == "Test Plug-in") { callback(tags[i]); return; } } }; }; This would make it harder to blindly assume the test plugin exists. Thoughts? Also, on less substantial concerns, please use camelCaps naming for APIs instead of under_scoring, and make the file something like PluginUtils.js or similar (every word in the identifier capitalized), but in any case I think this isn't quite what we want.
Attachment #364052 - Flags: review?(jwalden+bmo) → review-
Comment 16•
14 years ago
Jeff, I've trouble to make ("Components" in this) work there. I think "this" is class PluginUtils here.
Comment 17•
14 years ago
Attachment #364052 - Attachment is obsolete: true
Attachment #368207 - Flags: review?(jwalden+bmo)
Comment 18•
14 years ago
Comment on attachment 368207 [details] [diff] [review] patch v4 Sorry for the delay on this... >diff --git a/content/base/test/test_bug391728.html b/content/base/test/test_bug391728.html >+ if (!PluginUtils.withTestPlugin(start_test)) >+ SimpleTest.finish(); Nice call on making the return value indicate whether the test plugin was present or not, should have thought of doing that myself. > // We must delay to wait for the plugin sources to be loaded :( >- setTimeout(gNextTest, 500); >+ setTimeout("PluginUtils.withTestPlugin(gNextTest)", 500); Make this |function() { PluginUtils.withTestPlugin(gNextTest); }| please. The string form of setTimeout is more easily susceptible to abuse than the lambda form, in general, and I'd rather our code be idiomatic. >diff --git a/testing/mochitest/tests/SimpleTest/PluginUtils.js b/testing/mochitest/tests/SimpleTest/PluginUtils.js >+var PluginUtils = >+{ >+ withTestPlugin : function(callback) >+ { >+ netscape.security.PrivilegeManager.enablePrivilege("UniversalXPConnect"); >+ var ph = Components.classes["@mozilla.org/plugin/host;1"] >+ .getService(Components.interfaces.nsIPluginHost); Oh, rookie mistake on my part forgetting about this-binding like that. Guard with |if (typeof Components === "undefined") return false;| instead.
Attachment #368207 - Flags: review?(jwalden+bmo) → review+
Comment 19•
14 years ago
Attachment #368207 - Attachment is obsolete: true
Attachment #373809 - Flags: review?(jwalden+bmo)
14 years ago
Attachment #373809 - Flags: review?(jwalden+bmo) → review+
Comment 20•
14 years ago
Pushed: http://hg.mozilla.org/mozilla-central/rev/f46bebbe48e6
Status: ASSIGNED → RESOLVED
Closed: 14 years ago
Resolution: --- → FIXED
Target Milestone: --- → mozilla1.9.2a1
Comment 21•
14 years ago
Comment on attachment 368207 [details] [diff] [review] patch v4 >diff --git a/modules/plugin/Makefile.in b/modules/plugin/Makefile.in > ifdef ENABLE_TESTS >-ifneq (,$(filter WINNT Darwin Linux,$(OS_ARCH))) >+ifneq (,$(filter WINNT Darwin Linux SunOS,$(OS_ARCH))) > DIRS += test If this patch makes the test produce a reasonable TODO on all platforms, why only run it on these?
Comment 22•
14 years ago
(In reply to comment #21) > (From update of attachment 368207 [details] [diff] [review]) > >diff --git a/modules/plugin/Makefile.in b/modules/plugin/Makefile.in > > ifdef ENABLE_TESTS > >-ifneq (,$(filter WINNT Darwin Linux,$(OS_ARCH))) > >+ifneq (,$(filter WINNT Darwin Linux SunOS,$(OS_ARCH))) > > DIRS += test > > If this patch makes the test produce a reasonable TODO on all platforms, why > only run it on these? Because the test plugin may not built successfully on some platforms, it would block the build process.
9 months ago
Product: Core → Core Graveyard
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For locals who love sports, outdoors, and shoes…Scheels is the best place to go. They have won #1 for 15 solid years for Footwear, Men's Hobbies and Sporting Goods.
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Thanks, Scheels. Because of you, we are well equipped for our outdoor adventures, stylish in our shoes, and ready for the game.


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When you need help with your plumbing, heating, or cooling, call us at Surfin' Plumbers, Heating & Cooling right away. We'll have a skilled expert at your front door fast to resolve all of your home's issues.
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[Full Text]
Asep Darmansyah, Tettet Fitrijanti
Accounting Information, Accounting Information System, Cane, Computerized, Managerial Performance, Sugar Industry.
The study aims to determine characteristics of Indonesian sugar industries, as well as the influence of the implementation of computer-based accounting information system (CBAIS) to the quality of accounting information and managerial performance of the sugar industries of Indonesia. The research method was a survey with the research type was a descriptive and verificative. The research population were sugar industries in Indonesia. Data consists of primary and secondary data. Data were analyzed making use of linear regression. This study shows that the sugar mills/industries of Indonesia are mostly located in Java. Most of the sugar industries either in Java or outside Java are owned the central government in the form of state-owned enterprises and the rest is privately owned. Most of them making use of a business area with a mixed pattern between the right to cultivate and the right to build. Most of sugar industries gained canes in two ways namely planted by its company and bought from farmers. Then the first variable, the application of CBAIS of sugar industries is still categorized sufficient, which indicates the condition is not very bad or not very good. The others, the quality of accounting information of sugar industries is good category and its managerial performance is also good. The three variables above have not shown the ideal category namely is very good category. The application of CBAIS significantly affects on the quality of accounting information and the accounting information quality significantly influences on managerial performance of sugar industries.
[1] Yusbar Y.; A.F. Aulia; S. Martadi, �Permintaan Gula Pasir di Indonesia,� Jurnal Ekonomi Vol 18 No. 03 (2010), Lembaga Penerbit Fakultas Ekonomi Universitas Riau, Pekanbaru.
[2] Syafa�at, dkk., �Laporan Akhir Pengembangan Model Permintaan dan Penawaran Komoditas Pertanian Utama,� Pusat Penelitian dan Pengembangan Sosial Ekonomi Pertanian Balitbang Departemen Pertanian, Jakarta, 2005.
[3] Surono, S., �Akankah Berhasil Swasembada Gula Tahun 2014 ?� Jurnal Manajemen Usahawan Indonesia, Vol. 40 No. 4 (Juli � Agustus 2011), 433-450.
[4] Dewan Gula Indonesia, �Laporan Gula Indonesia (beberapa tahun),� Jakarta, 2010.
[5] http://www.kemenperin.go.id/artikel/21/Revitalisasi-Industri-Gula (February, 18. 2013)
[6] http://www.kemenperin.go.id/artikel/4326/Revitalisasi-Pabrik-Gula-Kemenperin-Gelontorkan-Dana-Rp.-154-Milyar
[7] http://www.investor.co.id/agribusiness/pemerintah-benahi-manajemen-pabrik-gula/46584 (January 4, 2013).
[8] Mihailovic, Ivan; Randelovic, Dragana; Stojanovic, Dragan, �Accounting Information as Resource for Business Decisioning,� Scholarly Journals, Faculty of Tourism and Hospitality Management in Opatija, Biennial International Congress, Tourism & Hospitallity Industry : 1067-1074, 2010.
[9] Soudani, Siamak Nejadhasseini, �The Usefulness of an Accounting Information System for Effective Organizational Performance,� International Journal of Economics and Finance, 4.5 (May 2012): 136-145.
[10] Weydan, Lu�ay Mohammad Abdel-Rahman; Gharaibeh, Adnan Turki Said; Abu-dawleh, Ahmad Ibrahim Mohammad; Hamatta, Hatem S. Abu, �The Affect of Applying Accounting Information System on the Profitability of Commercial Banks in Jordan (A field study from Management's Viewpoint),� Journal of Management Research, 4.2 : 112-138, 2012.
[11] Bawaneh, Shamsi S., �Information Technology, Accounting Information System and Their Effects on the Quality of Accounting University Education : An Empirical Research Applied on Jordanian Financial Institutions,� Interdisciplinary Journal of Contemporary Research In Business, 3.2 (Jun 2011): 1815-1840.
[12] Jamil Abdallah, Ahmad Adel, �The Impact of Using Accounting Information Systems on the Quality of Financial Statements Submitted to the Income and Sales Tax Department in Jordan,� European Scientific Journal, suppl. December 2013/SPECIAL/edition vol.1 ISSN : 1857�7881 (Print) e-ISSN 1857-7431.
[13] Sulub, Saed Ahmed, �The Impact of Computerized Accounting Information Systems on Reducing Costs in Somaliland Business Companies,� SSRN Working Paper Series Rochester : Social Science Research Network. (May 2014).
[14] El-Dalabeeh, Abd el-Rahman kh; Alshbiel, Seif Obeid, �The Role of Computerized Accounting Information Systems in Reducing the Costs of Medical Services at King Abdullah University Hospital,� Interdisciplianary Journal of Contemporary Research In Business, 4.6 (Oct 2012) : 893 � 900.
[15] Darmansyah, Asep and Tettet Fitrijanti, �The Influence of Managerial Style and Implementation of Computer-Based Accounting Information System (CBAIS) on Managerial Performance of Indonesian Sugar Industries,� Research Journal of Finance and Accounting, Vol. 6 No. 10, pp 228-238, 2015.


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Newest to the Perle collection this black necklace features man made pearls combined with crystals and black beads, a hung delicately onto a stainless steel chain.
It sits perfectly on the bust at 80cm in length, with a 5cm extender chain if you desire more length. This necklace has matching earrings and other colour options available.


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Leah was a member of the Hunter swim club where she became a member of the Australian national team and finaled at the 2012 Olympic trials as well as the 2011/2013 World Champ Trials. She decided to pursue her swimming career in the US to swim for the University of Alabama where her main events were 100 and 200 fly. Afterwards, she moved to Panama City Beach, Florida and coached kids from ages 5-15 with the Panama City Tsunamis. Now, she is back in her Australian hometown of Newcastle coaching both on deck and on land. Her love for swimming translates into her coaching. She believes in the everyday life skills that swimming gives us and is working to pass them onto the next generation of swimmers.
Connect with Leah:
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VPNs are a popular way to browse and use the internet, but for some reason, even in 2022, they are still not fully understood. We're going to break it down for you so you fully understand what a VPN is and why so many use it to protect their privacy.
What is a VPN?
Let's start with a simple definition. What is a VPN exactly? Understanding what the abbreviation stands for will probably clear it up right then and there. The letters VPN are short for Virtual Private Network. It's almost self-explanatory, right?
It's essentially a closed off network or channel in which you can access and browse the internet without anyone, hackers or otherwise, intruding on your activity. This private, encrypted tunnel is where all of your data will be sent and received as long as you're logged in.
Because there's no outside access into your VPN, bad actors and unscrupulous organizations can't access your browsing history or glean your location. This is especially useful when using a public Wi-Fi network.
Typically, people use a VPN in order to hide their location. The VPN accomplishes this by hiding the user's IP address. It's able to do this by assigning random IP addresses whenever you log in to your own VPN. Think of it like an intermediary between you and the internet. It shields you from anyone or anything outside your secure tunnel.
Do VPNs Cost Money?
As you can imagine, creating a secure channel from which you can carry out all of your internet activities worry-free is no small undertaking. A lot goes into making sure your privacy is a priority, so you can expect VPNs to cost money.
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Paige VanZant worked hard to establish herself as one of the most popular female stars in the MMA world, but for things outside MMA. Her current record in the world of combat sports is quite mediocre as well. She also decided to give fans something to be happy about.
The former UFC fighter signed a contract with AEW earlier this year. After a lot of training, she made her in-ring debut at AEW Double Or Nothing and was victorious in the match.
The blonde bombshell took to her Instagram and uploaded a photo of herself doing a handstand while wearing a skimpy bikini. Clearly, fans were impressed by it as well.
PVZ also gets paid a lot of money for her Instagram photos. Only time will tell when she returns to AEW. Her next Bare Knuckle Fight was also cancelled. In the meantime, you may check out her photo below!
Do you want to see Paige VanZant back in AEW? Sound off in the comments!


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Note: iDataPortal My Child is no longer available. Users are redirected to our new mySAISD website when they try to access iDataPortal MyChild. SAISD parents and students have access to mySAISD online and mobile app to stay up-to-date on grades, attendance, assessments and much more.
mySAISD is a mobile app for San Antonio I.S.D. parents and students to access grades, attendance, assessments, class schedules, school information, student photos, set up mySAISD Alerts and more.
Parents can now stay more up‐to‐date on their child's school progress with access to more frequently updated grades and attendance and customizable alerts for class averages, assignment grades, attendance posting and STAAR assessment results. Students have access to most of the same information that parents do as well as a student dashboard with information on recent and last posted grades, attendance, state assessments, homework and messages. An email message feature is built into the app to easily and quickly send messages to teachers or campus administrators.
Parents will have more control of their mySAISD account with functionality to update their email address, phone number, password, security questions and add additional children to their account.
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- This event has passed.
World Health Day Wellness Event : POC Community Development
April 7, 2022 @ 6:00 pm - 7:30 pm EDT$15
Join us in our wellness and meditation event for people of color in community development to commemorate World Health Day.
In commemoration of World Health Day on April 7th, The Empowered Block is hosting a wellness event for people of color who work in community development. As community development professionals, we are responsible for taking care of our respective communities through organizing, advocacy, political campaigns, and other technical expertise.
During this event, we will discuss what wellness means to community development professionals of color and how to incorporate wellness strategies in our lives. We will hold a meditation session led by Tianna Christine so that we can ground ourselves individually.


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Racked is no longer publishing. Thank you to everyone who read our work over the years. The archives will remain available here; for new stories, head over to Vox.com, where our staff is covering consumer culture for The Goods by Vox. You can also see what we're up to by signing up here.
Good news for wardrobes in need of affordable basics: starting today, you can pre-order Norma Kamali's under-$100 collection KamaliKulture. The new collection, which is heavy on travel-friendly jersey dresses and laying pieces, doesn't arrive online until February 21, but the brand is offering the order-before-it-hits-stores option to anyone who signs up for their mailing list. Since the pre-ordering is traditionally the realm of high-end collections, we're pleased to see brand's with accessible price points getting in on the game—just think how this would revolutionize Target's next collab. Check out the collection in the gallery above.
· Kamali Kulture [Official Site]
· All Norma Kamali coverage [Racked]


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Live and Learn Series Grandpa Has Changed
Vente Épuisé
Prix habituel $14.80 CAD
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Live and Learn Series Grandpa Has Changed When their grandfather begins forgets things, Mom explains to a brother and sister about Alzheimer's, and the children learn Grandpa loves them just as much today as he did before. 36 pages. Ages 4-7 Grade: All


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The Paintings, Watercolors and Drawings of Paul Cezanne
An online catalogue raisonné under the direction of Walter Feilchenfeldt, Jayne Warman and David Nash
Nature morte: pêches et poires
Alternate title: Peaches and Pears
Rewald: (W210); Venturi: (861) 1879–82; Venturi revised: 1875–77
Graphite and watercolor on yellowed paper
13 3/4 x 19 3/4 in. (35 x 50.2 cm)
Private collection, London
Record last updated March 27, 2020. Please note that the information on this and all pages is periodically reviewed and subject to change.
Citation: Feilchenfeldt, Walter, Jayne Warman, and David Nash. "Nature morte: pêches et poires, 1882–85 (FWN 1904-TA)." In The Paintings, Watercolors and Drawings of Paul Cezanne: An Online Catalogue Raisonné. https://www.cezannecatalogue.com/catalogue/entry.php?id=1190 (accessed on January 27, 2023).


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For the Love of Work Podcast
Episode 3: The Employee Experience is a Relationship. How To Land At The Right Company
Finding the job that ticks all the right boxes can seem like an impossible task. But what if you're not looking for the right things?
Well, there's a big shift occurring in the workplace, as progressive companies start focusing on something called the "employee experience" – a holistic relationship between a company and its staff. Host Dr. Sonia Kang takes a deep dive into the employee experience to uncover the criteria that helps you determine the right companies, the right tools, and the right people for advancing your career.
Guest Experts:
- Jacob Morgan, author of The Future Leader, outlines the three pillars of the employee experience, and tells us how you can identify if a company offers them. @jacobm
- Katy Milkman explains how our cognitive biases inform the decisions we make about where to work, and how to avoid making wrong decisions. @katy_milkman @SJDM_Tweets
- Shopify's culture team design lead Mandira Midha and social scientist Pete Bacevice shares her insights on how our physical and digital workspaces – both in the office and in the home – influence our productivity, behaviour, and even our ability to successfully collaborate. @mandiramidha @shopify @bacevice
- Joe Berger tells us how technology shapes our relationship with work, and how the modern employee experience promotes a seamless integration of devices and tools into our everyday workflows. @jberger26 @wwt_inc
For the Love of Work is made possible by Rogers.


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The tough thing about being an NFL cornerback is that when you do your job well, nobody talks about you. Atlanta Falcons CB A.J. Terrell was thrown into the fire as a rookie in 2020, and despite some rough patches, he's managed to quiet a lot of the criticism the team received when drafting him 16th overall.
Entering his second year, the former Clemson standout will lead a completely revamped Falcons secondary as it transitions to Dean Pees' defensive scheme. It won't be easy, but Terrell has yet to back down from a challenge.
Check out the new mic'd up segment featuring Terrell, as shared by the team's Twitter account below.
Big season ahead for @ajterrell_8!— Atlanta Falcons (@AtlantaFalcons) August 27, 2021
We mic'd up the CB at practice 🎙 pic.twitter.com/ePThVFs9vJ


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Hearts manager Robbie Neilson has made the Edinburgh club's position on Rangers-linked John Souttar and other soon-to-be out-of-contract stars clear ahead of the January transfer window [Daily Record].
The Gers have been linked with Souttar for some time and he's currently in excellent form.
He's been a big part of the Jambos' strong start to the season and he returned to Scotland colours with a bang last month, scoring in an impressive win over Denmark.
Earlier this week, it was reported that Blackburn had opened pre-contract negotiations with the 25-year-old centre-back [Daily Record].
However, it was also asserted that despite the initial links coming during Steven Gerrard's time at Ibrox, new boss Gio van Bronckhorst 'hasn't closed the door' on a move for Souttar.
One potential way to increase Rangers' chances of landing the defender would be to make an offer to sign him next month, rather than going down the pre-contract route.
However, Neilson says offers for players approaching the end of their contracts will need to be substantial or they will be turned down.
"We've obviously got a number of players out of contract but we're not in a situation where we need to sell them," he said [Daily Record].
"I've had a chat with sporting director Joe Savage and the board. And we know that, unless somebody comes in willing to pay really big money for somebody, they'll stay here until the end of the season because the objective this season is to get into Europe.
"And that financially is worth a lot of money to the club – certainly enough to outweigh any mediocre bid we're going to get for a player.
"It's good to be reassured on that front. We've got a strong board and financially we're in a good position so we don't need to sell. I'm confident that will be the case."
Rangers sent clear Souttar message by Hearts boss
Rangers may well be interested in Souttar heading into the January window and that would make sense.
He's been one of the top performers in his position in Scotland so far this season and the Gers have looked light at the back for the majority of the campaign.
However, it's clear that this will be harder to pull off than some previous January transfer deals.
Rangers took advantage of contract situations to bring in the likes of Glen Kamara and Scott Wright from Dundee and Aberdeen in recent seasons for nominal fees.
In this instance, though, not only would they be dealing with a club determined to get a fair price, but there's also substantial competition from south of the border.
Rangers will need to move quickly if they are to land Souttar and it'll be interesting to see whether or not a bid is tabled during the first few days of the window.
Meanwhile, a Premier League manager has addressed his January transfer plans and it's good news for Rangers.


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Plus, receive recommendations and exclusive offers on all of your favorite books and authors from Simon & Schuster.
The Christmas Rat
Table of Contents
About The Book
He is one weird Christmas visitor -- his hair and moustache an unearthly white-blond, his voice a gruff rumble. He fills the apartment doorway. From two metal cases he produces what a boy would expect from an exterminator: Toxic roach powders and poisonous fog bombs.
But a crossbow?
Eric is fascinated at first. He's been bored this snowbound vacation, and has already zapped about a zillion Zergs. Antsy, he's even sneaked a look at the Christmas presents hidden beneath his parents' bed. Then Anje Gabrail, this exterminator, appears, talking a little madly about his war against rats -- about killing them.
"The worst," Anje says. And if Eric sees one in the Eden Apartments, he is to call Anje's twenty-four-hour cell phone immediately. Later that Monday, the fourth day before Christmas, a rat does appear in the building's basement -- and Eric finds himself suddenly, frighteningly swept into Anje's vengeful army.
As either partner...or victim.
With only a flashlight.
About The Illustrator
Leonid Gore moved to the US from his native Belarus in 1991. He has illustrated many beloved books for children and is also the author and illustrator of Danny's First Snow. Mr. Gore lives in Oakland, New Jersey. Visit him online at LeonidGore.com.
Product Details
- Publisher: Atheneum Books for Young Readers (March 17, 2015)
- Length: 144 pages
- Grades: 3 - 7
- Ages: 8 - 12
- Lexile ® 500L The Lexile reading levels have been certified by the Lexile developer, MetaMetrics®
Browse Related Books
Awards and Honors
- Children's Literature Choice List
Resources and Downloads
High Resolution Images
Book Cover Image (jpg): The Christmas Rat
eBook 9781481445344
Author Photo (jpg): Avi
Photograph by Katherine Warde(0.1 MB)
Any use of an author photo must include its respective photo credit
More books from this illustrator: Leonid Gore
You may also like: Thriller and Mystery Staff Picks
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From heart-pounding thrillers to poignant memoirs and everything in between, check out what's new this month.


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