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Online casino games are a great way to spend free time, enjoy chats with other fellow players, and relax. There are numerous online casino websites and apps that you can choose from, depending on where you live, which games you prefer, and which gambling experiences you fancy.
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Our writers complete papers strictly based on your directions and wishes, no matter what college, college, or highschool you examine in. Some school and college departments keep the work of their earlier students which incorporates term paper, research paper, and essay examples. You may look at them earlier than you begin writing your paper or essay for inspiration. Nonetheless, if there isn't any library of such work in your college or school, do not panic. Use our collection of free essay samples and analysis paper samples as your writing guides.
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I have been a fan of Ricky Jay's for nearly a quarter century, when my ex got a copy of Learned Pigs and Fireproof Women for Christmas circa '88, inspiring my exploration of vaudeville, circus and allied variety arts that continues to this day (the book became mine after I spilled beer all over it). I had always been interested in circus and vaudeville and so forth, but reading that book inspired the rather intense focus I've given those subjects ever since. It also inspired my play The Strange Case of Grippo the Apeman, which is largely based on the famous idiot savant "Blind Tom," whose story is recounted in the book.
At any rate, Deceptive Practice tells the amazing story of Jay's own life, casting him as the product of the many mentors who've taught him, largely in his own words (with a narrational assist from Dick Cavett). Born Richard Jay Potash, Jay was the grandson of an amateur magician with many close friends among the professionals. (Magic is one of those rare fields where it's possible to be a well-respected amateur). His grandfather was friends with the likes of Al Flosso, Slydini, Roy Benson and Cardini, from all of whom he learned. The film has footage of the young Ricky Jay doing magic on television in clips when he was as young as five years old. In his teens, he performed at the Electric Circus, wedged between Timothy Leary lecturing on acid, and Ike and Tina Turner. In his twenties, the long haired Jay was a fixture on The Tonight Show, The Dick Cavett Show and the Dinah Shore program — a terrific clip has him fooling around with a very early-career Steve Martin. Then, he CONTINUED to learn, spending long hours at the Magic Castle in LA under the tutelage of legends Dai Vernon and Charlie Miller.
By the 80s, it is of course, Jay himself who is the legend, with his books, his one-man Broadway shows, and later, the appearances in the films of David Mamet, and Paul Thomas Anderson, as well as David Milch's Deadwood. The film take us as close as we're probably going to get to a man who makes subterfuge and deception his life's work. Even people who know him well like Mamet and Michael Weber (Jay's business partner) shed no light on what makes him tick; they don't even try to. Why? The answer I think lies in an anecdote told by a journalist who spent several hours with Jay on a hot, miserable day, after having spent several miserable weeks on a film shoot, only to have him surprise her with a special, once-in-a-life time illusion designed only for her. It's the sort of memory one takes with oneself to the grave, but only because it seems like a miracle. The woman is visibly moved as she recounts the story. Why spoil things by meddling in how he did it?
At any rate, as proud owner of a copy of this film, I intend to watch it and watch it and watch it. There's inspiration aplenty for any sort of vaudevillian here. We'are all illusionists if we're doing it right.
For my earlier tribute to Ricky Jay, go here.
To find out more about the history of vaudeville,consult No Applause, Just Throw Money: The Book That Made Vaudeville Famous, available at Amazon, Barnes and Noble, and wherever nutty books are sold.


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This website will be dedicated to a feline who has taken a special place in the hearts of fellow enthusiasts, the Chantilly/Tiffany. Here the rebuild of the breed and revaluation of its history will be discussed, so the Chantilly can make its return to warming the hearts and souls of those who are lucky to find a companion in these lovely creatures.
Check Out Our Newest Update:
New Tab – Other Interesting Reads
New Completed Research Essay: A Critical Conjuncture in Feline Preservation. Ancient breeds deserve recognition


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The Premier League insist they have no plans to invite foreign referees to take charge of domestic matches in England next season. One report on Wednesday suggested Spanish official Manuel Mejuto Gonzalez had been invited to referee in the Premier League next season.
However a spokesman for Professional Game Match Officials Ltd - the body that runs the referees - insisted that was not the case.
A PGMOL spokesman said: "There are no discussions regarding the use of foreign officials in the English game and the Professional Game Match Officials Ltd (PGMO) has no plans to do so."


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Measure your wellbeing impact
A practical guide for charities and social enterprises
Whether you want to improve health, education or employment, measuring wellbeing can show you the wider impact you have on the people and communities you support.
This guide was designed for people who may have lots of different functions in an organisation, with very busy working days. The guide allows you to dip in and out of the content as you need, and work at your own pace.
Want help to generate, use and get the most out of wellbeing data?
We offer free, one-to-one advice surgeries specifically designed to support practitioners working in the charity sector. Book a slot here for practical guidance on how to generate, use and get the most out of wellbeing data.
You'll find this guide useful if you:
- work for a small or medium-sized charity or social enterprise that runs projects, programmes or activities that aim to improve people's wellbeing
- are responsible for reporting, evaluation or learning; and are interested in evaluating how your activities affect wellbeing
- want to develop your knowledge of wellbeing concepts and measures and learn how to design and carry out a wellbeing evaluation
By using this guide you can:
- understand wellbeing better
- find out what really matters to the people you support
- show others the difference you make to people's lives
- improve what you do and have an even bigger impact.
Evaluating wellbeing during the pandemic:
The Covid-19 pandemic has probably affected every aspect of your work – including what kind of activities you deliver and how, as well as your plans for the future.
Wellbeing is even more important in this context, and it's still possible to carry out a meaningful wellbeing evaluation – though there are a few additional things to consider.
So while this guide is relevant to wellbeing evaluations in general, we have added some pointers that refer to evaluating your impact during the Covid-19 pandemic.
Look out for this symbol for additional advice and things to bear in mind when evaluating wellbeing during the pandemic.
Let us know how you're getting on
We want this guide to be helpful and easy to use. If you have any questions, feedback or suggestions about it, please get in touch. You can also use our online forum to discuss how others are getting on with our guide and their survey. We'd love to see any wellbeing evaluations you create, so please send us your reports, case studies or summaries to show us how you got on.
Email us at firstname.lastname@example.com


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Here's our (growing) list of collaborators from around the world –
Yusuf Abushamaa
Yusuf is an Egyptian architect and urban designer who graduated from the University of Sheffield with an MA in Architectural Design in 2017. His research discusses the dilemma between formality and informality, testing how social participation and ground practices could enable a community-based understanding of cities. He takes a keen interest in understanding how research and practice could together form a sustained platform for future architecture. To further his interests, he has participated in conferences like the "In/ Out: Designing Urban Inclusion" conference in Brussels, Belgium and the PhD conference, in Sheffield, UK. He has also worked with the DAR Group on projects in the Middle East & Africa.
Posts by Yusuf
Stany Babu
Stany holds an MA in Architectural Design from the University of Sheffield and a B. Arch from SRM University, Chennai. She has experience working in various cities within India along with experiences in Bahrain and the UK. Currently she is working as a lecturer at the University of Bahrain while also collaborating with Mawane on public space projects in Bahrain. Her current research interests include politics of urban spaces in India, memory, identity and politics of architecture during conflicts and socialist modernism heritage with particular focus on Yugoslavia. She has presented a research paper in international conference on Urban Conservation 2018 held in Kolkata.
Posts by Stany
Kasthuri Priya
A holistic designer, Kasthuri Priya strives for seamless transitions between landscape, architecture and interiors, creating soulful and symbiotic spaces that are mutually inclusive of each other. She graduated from the Sheffield School of Architecture in 2017 with a specialisation in Digital Architecture where her research focus was on the utilisation of technology in humanising the design, making it more inclusive and participatory. A GRIHA certified professional, practicing architect and interior designer, she is passionate about sustainable building practices, materials and technology.
Rohit Rao Vantaram
Rohit is an architect from Chennai who currently works within the realm of Adaptive Reuse in San Francisco's Historic Conservation District. Graduating from the Rhode Island School of Design in 2017 with an MA in Interior Architecture, Rohit is passionate about the reuse of buildings and his position as a designer that can enable this (adaptive) reuse of structures in our existing built environment.


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Unlike the SGR's annual changes, MIPS adjusts physician payments based on performance. MIPS does not have an aggregate spending target, which is what previously created the need for annual congressional patches to prevent the mandated SGR cuts. MIPS started in 2017 at ±4 percent and increases to ±9 percent by 2022 (based on 2020 performance).
Explore This IssueACEP Now: Vol 37 – No 01 – January 2018
Future Changes to the Medicare 1995 and 1997 Documentation Guidelines
CMS has become concerned that the current documentation guidelines, particularly the burdensome aspects of history and physical exam documentation, have not kept pace with technology and has discussed moving to a set of guidelines that are more centered on medical decision making.
Ultimately, in the 2018 Physician Final Rule CMS stated: "Stakeholders have long maintained that both the 1995 and 1997 guidelines are administratively burdensome and outdated with respect to the practice of medicine, stating that they are too complex, ambiguous, and that they fail to distinguish meaningful differences among code levels. In general, we agree that there may be unnecessary burden with these guidelines and that they are potentially outdated, and believe this is especially true for the requirements for the history and the physical exam."
Stay tuned, as CMS has forecasted making substantial revisions in the near future.
Dr. Granovsky is the president of Logix Health, an ED coding and billing company, and serves as the course director of ACEP's coding and reimbursement courses as well as ACEP's Reimbursement Committee. Mr. McKenzie is reimbursement director for ACEP
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Dance With Me
Dance With Me was the first album by Long Beach punk band T. S. O. L. (TRUE SOUNDS OF LIBERTY). Originally released on Frontier Records in 1981, the album hasn't been available since 2007 when it was reissued by The Offspring's Nitro Records. Dance With Me saw the band move away from the hardcore punk roots of their debut EP...


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Ibrahim, Olson named First-Team All-Big Ten by Phil Steele Publications
The Minnesota Golden Gopher football team should have no problem scoring points next season as 10 players were selected to Phil Steele Publication's preseason All-Big Ten Team for the 2021 season.
Of the 10 players, seven were on the Gophers' offense, with running back Mohamed Ibrahim and Conner Olson named to the first team.
Ibrahim was one of the few bright spots for the Gophers last season, leading the conference with 1,076 rushing yards and 15 touchdowns on his way to winning the Big Ten Running Back of the Year Award.
Olson should be an anchor for an offensive line that was decimated by injuries and opt-outs last season. With the return of Daniel Fa'alele and Curtis Dunlap Jr., the Gophers should have a much-improved unit in the trenches that returns fellow starters Sam Schleuter and Blaise Andries.
Andries was one of two Gophers that made Steele's second team along with quarterback Tanner Morgan. Morgan had a tremendous 2019 season while leading the Gophers to an 11-2 record and finishing fifth in quarterback efficiency but took a step back last season.
While Morgan's completion percentage dipped from 66 percent in 2019 to 58.6 in 2020, he should have more help from his receiving core including third-team selection Chris Autman-Bell.
Autman-Bell was the Gophers' leading receiver last season after snagging 22 passes for 430 yards and a touchdown. He's joined on the third team by Fa'alele and a pair of defensive standouts in cornerback Coney Durr and Clemson transfer and defensive lineman Nyles Pinckney.
Linebacker Mariano Sori-Marin also made the fourth team after leading the Gophers with 54 tackles last season.
With the Gophers announcing that all athletic events will be held at full capacity next season, there should be plenty of excitement for the nationally televised opener against Ohio State on Sept. 2.


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Hallettsville edges Coahoma 6-5 for Class 3A softball title
AUSTIN — Heading into the seventh and final inning of Thursday's Class 3A state championship against Hallettsville, the Coahoma Bulldogettes were in a familiar position.
They trailed the Lady Brahmas 6-5, the same score at the beginning of the seventh on Wednesday, when Coahoma rallied to beat Franklin 14-10 in the semifinals.
This time, though, Coahoma couldn't get it done.
The Bulldogettes went down in order as Hallettsville escaped with a 6-5 state title win. Coahoma finishes 33-5-1 overall.
"We gave it a heck of a ride," Coahoma head coach Alexander Orosco said. "My heart breaks for them."
Coahoma had offensive flashes early, but Hallettsville always had an answer.
The Bulldogettes took a 1-0 lead in the top of the first when freshman Hannah Wells hit an RBI single. The Lady Brahmas answered in the bottom half, when Carson Jansky hit an RBI single of her own.
Coahoma plated two more in the top of the top of the third on a Wells sacrifice fly and an Avery Rodriguez single. But the Lady Brahmas responded again, scoring two runs on an infield error to tie it at 3-3.
After that, Hallettsville's offense kept going as Coahoma's went dry. The Lady Brahmas combined for three runs in the fourth and fifth innings to take a 6-3 lead.
Errors and wild pitches were costly for Coahoma during this stretch, as the Bulldogettes had three of each.
And after throwing 151 pitches in the semifinals, fatigue was apparent for Wells, who pitched the entire game for Coahoma.
"When you have a player like that, you develop a player-coach relationship," Orosco said. "She was going to go until she said, 'I can't.'"
Despite that, Coahoma didn't go away easily.
With Shae Lang and Brynn Rodgers on second and third, respectively, Neveah Kerby got on with an error that drove in both runners. Hallettsvile's infielders collided as the ball fell between them and the Bulldogettes cut the lead to one (6-5).
A batter later, Madison Rodgers belted a single to center field and Kerby prepared to round third and go home. But Orosco held up the stop sign and kept Kerby at third.
"I saw a clean field and a clean throw and a clean catch," Orosco said. "Our girl was still a foot within the plate."
Coahoma catcher Macie Jansky gunned Rodgers down stealing, ending the inning and crushing the Bulldogettes' momentum.
Though Coahoma couldn't bring Kerby across, Orosco said he doesn't regret holding her at third.
"The rule of thumb is just don't get the third out at home," the coach said. "We did that, and it just didn't work out."
While Wells pitched a scoreless sixth, Coahoma's offense couldn't work any seventh-inning magic. Karleigh Burt, Wells and Rodriguez went down in order, ending the season.
Coahoma didn't play a perfect game. But Orosco applauded his team's effort, losing by just one run in the season's final game.
"Everybody says it goes by fast, and they weren't lying," Orosco said. "It's a matter of plays. It's hard to second guess and it's hard to pinpoint, but overall, the battle that these girls displayed is phenomenal."
Wells earned her second loss of the season, allowing five earned runs on seven hits and five walks. She was bested by Kaylie Olivarez of Hallettsville, who ends the season 17-1.
Offensively, Madison Rodgers went 2-for-3, while Wells had two RBIs. Olivarez had two hits for Hallettsville, while Carson Jansky drove in two runs and earned tournament MVP honors.
Hallettsville's state title marks its first in program history. The Lady Brahmas finish the year 35-3 and on a 30-game winning streak.
"I don't want to take anything from them: They won this game," Orosco said. "They were sharp; they were crisp."
As for Coahoma, the Bulldogettes were unable to win their second state title. This year marked the program's sixth appearance at state and first state since 2008, and they'll have to wait until 2023 to try and win it all.
The future is bright for Coahoma, as the program graduates only two players: Madison Rodgers and Maci Green.
Orosco says the Bulldogettes are just getting started.
"A lot of them are freshmen and sophomores," Orosco said. "(Let's) regroup and make another run."
More:Coahoma needs extra innings to overcome Franklin in Class 3A softball semifinal


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Cushendall put in a brilliant second half performance, early points from Mc Gill, Conor Carson and Shane Mc Naughton turned the game and Cushendall never looked back. In the final quarter Eunan Mc Killop, Campbell and Paddy Mc Gill added points and in injury time Mc Gill and Campbell scored vital points as Loughgiel sub Donal Mc Kinley goaled to leave the final score Loughgiel 1-11 Cushendall 0-16.
How they played: Cushendall showed great heart and determination to deny Loughgiel. Ronan Kearney was sound in goals and in front of him Aaron Graffin and Neil Mc Manus provided the bedrock for the defence. Aidan Mc Naughton and Paddy Mc Gill shaded the midfield exchanges and up front Conor Carson and Brian Delargy got through a mountain of work however my man of the match goes to Eoghan Campbell who produced an sensational performance, he gave his man a torrid time and crashed over five brilliant points.
Team: 1. R Kearney 2. S Delargy 3. A Graffin 4. M Burke 5. D Mc Naughton 6. N Mc Manus(0-2) 7. R Mc Grady 8. A Mc Naughton 9. P Mc Gill(0-4) 10. C Carson(0-2) 11. B Delargy 12. K Mc Keegan(0-1) 13. S Mc Naughton(0-1) 14. E Mc Killop(0-1) 15. E Campbell(0-5)
Subs used: P Mc Naughton


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Essaouira also has argon trees in the Anti-Atlas Mountains and has the perfect conditions for growing them. It seems like everywhere that you look, we see the argan trees.
Even though argan trees grow in Brazil and Israel, Morocco is the place where the fruit (nut) is produced. This means that it is only place that you can get oil. It is not edible … to humans at least.
Soussa people come from the Souss-Massa region. Morocco has 12 regions like we have states in the USA.
We drive through the small village of Tahala. The men have left women and children behind to find work in the big city.
Morocco has a lot of silver. Mining is a big operation here especially in Tizmit.
Agadir is known as the Berber capital. It is the tenth largest town in Morocco. It is a modern planned city since it was rebuilt after a 1960 earthquake. Everything was destroyed. There is no old city. One third of the population was killed and the other two thirds survived but their homes and shops did not.
We stopped in Agadir to buy a picnic lunch and eat it by the Atlantic Ocean. This huge supermarket called Carrefour rivalled anything that we have in the USA. It was fun to buy chips again, but we overbought.
While at the store, I needed to use the ladies room. Often, restroom users need to tip the lady who stands at the door and makes sure that the bathroom is tidy and well equipped. Sometimes there is no one there. Omar said that he didn't think that I needed a coin, but I saw a woman standing at her post. I walked in and proudly gave my tip to a lady who giggled. I had never received that response before. Apparently, she was waiting for a friend!! She kept my coin and I have a funny story worth more than I gave her. Crazy Americans!!
Many Scandinavians, Germans, and Russians come to this Agadir and Essaouira for a holiday. This is a place for surfing and picnics.
Tamwrit is known for small yet sweet bananas. These did not grow here originally but now there is a huge valley for bananas that runs to the ocean. We noted that no matter what a shop was selling, bananas were also available.
Essaouira is protected from the ocean by a wall. There is a new and old part. There are hundreds of shops and international restaurants. Many tourists like to come here.


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Toolholding Coming to grips with turbine and impeller machining
Switzerland - Excessive vibrations are the nemesis of surface quality and tool preservation. Not so for Liechti Engineering where toolmakers rely on a clever clamping system produced by their compatriots at Rego-Fix.
Related Vendors
Swiss toolmakers Liechti Engineering are keen on process reliability. The company manufactures milling and machining centres and supplies CAM software for producing the complex aerodynamic profiles of turbines, impellers and blisks.
With its long history of creating profile machining technology, Liechti claims reduced production times by up to 30%, an improvement its experts attribute to their know-how of handling advanced materials such as titanium, Inconel, Nimonic and high-alloy steels. Engineers at the Langnau-based firm have now concluded a long-term test of Rego-Fix's pow-R-grip System, a tool clamping system that claims improved reliability and reduced tool wear by virtue of its constant clamping force.
Related:All-rounder insert grade for ISO K applications
"We use the system that is best suited for constructing a workpiece," says Simon Trummer, a Liechti senior CAM application engineer. "Beside working with a reliable partner, we recommend the pow-R-grip system from Rego-Fix. We use it for our in-house finishing processes on turbine blades as its damping characteristics really ensure a flawless surface quality."


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In the STATION SUMMARY BLOCK there is a column for the number of decorations per station/contractor. Why should I care about the amount of decorations I have per station? Is there some benefit to game progression with decorations as opposed to no decorations?
It's just an indication of how much decorations you have placed, and the max you can place
Nothing more, nothing less


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"Will I ever break out of this routine?" I asked myself day in and day out. My work week was beginning to wear on me. I'm a middle school computer teacher in my thirties. I found that I had little time or energy for being social, and I wasn't finding real ways to connect with people at work or in social settings after work.
Three years ago, I moved to California in search of something different. I began socializing more, joined a few networking and personal development groups like Toastmasters which helped boost my confidence and public speaking skills, but I still felt something was missing, like I was still stuck in a routine. I tried the free Jaunty workshop, then signed up for the six-week course.
Over spring break, I boarded a crowded airplane on my way to Hawaii. A flight attendant was about to make a passenger leave the plane to check their luggage because all the compartments were full. I knew she was mistaken, so I spoke up and said I had seen some space available in one of the closed compartments. The passenger thanked me and I felt great having spoken up in a crowd. Now, I've found myself being assertive in all kinds of situations.
I recently volunteered as a photographer/videographer at the Mill Valley Film Festival, where I had the opportunity to network with actors and filmmakers. One day I was scheduled to record a Q&A session with a director after his film. I arrived an hour early and was surprised by the way a theater manager approached me. I could tell he was upset by his manner and the tone of his voice. Turns out he doesn't let camera operators film unless they're setup before the film begins. When he first approached me, I noticed he was wearing a really snazzy shirt, so when he said sternly "Do you have any questions?" I said, "Yeah nice shirt, where did you get it?" That sent our conversation going down a different path, and I was able to shoot the Q&A.
I can't say enough positive things about taking the Jaunty class. What I have learned has been the difference between getting to know someone new and letting that opportunity pass me by. But most importantly, it's a lot easier now to take typical "surface" conversations to a deeper, more meaningful level. I have had better conversations with coworkers, and I've even developed more positive relationships with students, which has translated into a greater level of success in the classroom. Before Jaunty, I felt sorta trapped in a routine, and now what I have learned has helped me break out of that routine while having fun doing it.


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By Serdar Yegulalp on 2014-08-04 14:00:00 No comments
It's been an unproductive day on multiple fronts, which ended with me shelving my current work and writing a few notes to people for the sake of further research on stuff I couldn't see from 30,000 feet up. In the long run it'll get worked out, but the short-term frustration that comes from hitting such a wall is always a bummer. When in such a state, I get philosophical.
Brad Warner has a nice post up about the way our happiness-seeking activities constitute a trick played on us by our brains. Many of the things we think will make us happy, don't. Or they only make us happy in a qualified sense: they only work because they're encouraged by a set of social circumstances, which is why bragging about your new car is generally wasted breath amongst people who can't drive. The point he makes is that we shouldn't give up on happiness, but that we should seek it differently — by looking at our desires as scrutinously as we can and understanding where they really come from and why.
You're also not going to be able to do this in the span of a weekend. I've been doing zazen on and off (more on than off, I'd say) for about six or seven years now, and even I still have bad days. The difference between then and now, I think, is that I let the bad days roll off my back better than I used to. Even when I'm confronted with something really miserable, it's easier to see the misery as a product of my interaction with the thing than the thing itself.
"But, but, but — " Yeah, I can hear it starting now. " — but the fact that it's me interacting with it is the only thing that matters!" I'm reminded of the Peanuts cartoon where Snoopy is stuck in his doghouse with a giant icicle threatening to impale him from above, and he thinks, "I'm too young to die! I'm too ME to die!" The same goes for anything else that happens to us: we're too "us" for that to happen to us!
And again, this is the part where people get all antsy. They don't like being told the "me" that they are is not real. It sure feels real when someone else punches them in the face, or when they open an envelope from the IRS and are greeted with a note asking for another thousand bucks they forgot to pay last year. And that "me", they argue, is the only "me" that actually matters. Someone has to pay my mortgage and show up at my job, right?
Well, sure. The point isn't to waggle the fingers and pretend that there's some mystical way all of these things can be avoided. That's wish-fulfillment, and that's not what this should be about. Instead, it's about seeing that whole "me" thing in a clearer light. If the only part of "me" that matters is the part that ends with your body, your bank account, your desk, and your car (to pick some arbitrary examples), of course it's going to hurt like hell when any of those things are threatened. Those threats shouldn't be taken trivially. But they also can't be divorced from the much bigger context in which they exist — a context which is, in turn, bigger than you alone.
The point isn't to replace one set of awareness with another, but to expand one to include the other. Do that long enough and after a while you see how "I" and "I want" are not the be-all and end-all of "you". And yeah, that sounds awfully silly when boiled down into so many words, but I suspect the silliness comes from the ways those kinds of concepts have been reduced to horrible clichés by people who are better at popularizing them than they are at practicing them.
I've meandered a bit, but I want to use this last point as my closing one. The real power of these concepts doesn't come from hearing them repeated as platitudes. Some platitudes deserve to be repeated — Leszek Kołakowski once noted that because they are platitudes, they run the risk of becoming ignored, and so deserve being revisited anyway. But the real power is underneath and inside them, from something you are enacting and not just talking about. Shy away from that and it becomes easier to take refuge in the easy ways the world, and our minds, give us to cope with such things, because they seem less silly and more real. Nobody laughs at a machine gun or a million dollars; the evidence for how those things rule us and our world is all around, and so we don't think of them as silly. But the evidence for how expanding your awareness of yourself as being more than just your body and your life is harder to come by — you have to come by it entirely on your own. Small wonder it gets giggled out of court far more often.


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Hello guys, back with us in the most interesting receipes site. If you are looking for best Sweetcorn carbonara recipe, you are now at the perfect place. We only serve excellent Sweetcorn carbonara recipe which will be very easy for you to follow.
We hope you got insight from reading it, now let's go back to sweetcorn carbonara recipe. You can have sweetcorn carbonara using 9 ingredients and 3 steps. Here is how you cook that.
Here are the ingridients that are required to make a yummy Sweetcorn carbonara:
- Provide 2 portions of spaghetti (or other pasta).
- Take 1 of onion.
- You need of About 225 g sweetcorn (I use frozen).
- Prepare 1/2 tsp of smoked paprika.
- You need of Black pepper.
- You need 1/2 of vegetable stock cube.
- Get 150 ml of cream (I use oat).
- Provide 1 of egg.
- Take of Grated cheese.
Ready with the ingridients? Here are the procedures on cooking Sweetcorn carbonara:
- Boil the pasta according to the pack..
- Finely chop the onion and cook in a frying pan with a bit of oil until transparent. Add sweetcorn, spices, stock cube and cream and simmer for a couple of minutes..
- Add the pasta and egg to the pan and mix well. Plate up and top with cheese. Enjoy!.
Humble ingredients—eggs, noodles, cheese, and pork—combine to create glossy, glorious pasta carbonara. It's the no-food-in-the-house dinner of our dreams. In this easy twist on a fave, sweet potato ribbons (spiralized or julienned sweet potato would also work) are tossed with mushrooms, bacon and butter-butter-butter for a quick. A spaghetti carbonara recipe is a failsafe classic. This Italian carbonara uses the traditional guanciale and pecorino cheese for a real taste of Italy.
A recipe is a good story that finishes with a enjoyable meal. If you find this page fruitful Sharing this site to your buddies is the deal Hope that your Sweetcorn carbonara turns your day cheerful.


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Run 3
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Welcome to Slime Ball! In this two-way soccer game, you take on the role of a slime. There are single-player and multiplayer modes, in addition to a number of other playable maps. It is possible for you to have a wonderful time and enjoy yourself! Playing football while disguised as slime is an incredibly enjoyable experience. This engaging game will absolutely prevent you from taking your eyes off of it because to its stunning graphical user interface as well as its highly lifelike sound and visual quality. Learn more about the game right now!


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Hardware: Colt Anaconda
Colt's popular "Snake Gun" revolver series gains a new addition with the updated Anaconda, featuring a fully adjustable rear sight, wide hammer spur, open-back rubber Hogue grips, replaceable front sight with orange insert, and a top strap already drilled and tapped for mounting optics.
Hardware: Colt Python
The new Python is a close copy of the original with the internal structural improvements that should provide you and your kids years of service. Fit and finish of the highly polished stainless-steel components are excellent with an attractive set of walnut grips that shame the older Python versions.
Hardware: Ruger Mark IV Hunter
A variation of the Ruger Standard, the Mark IV Hunter features stainless metalwork with a handsome, brushed satin finish, and a 7-inch bull barrel with six flutes. It's fitted with iron sights, but it's drilled and tapped for optics.
Top 5 Big-Game Handgun Hunting Cartridges
Having hunted with a handgun across the globe over the last five decades, contributor Dick Williams shares his top five big-game handgun hunting cartridges.
Can I Hunt With It: Springfield's M1A SOCOM CQB
Springfield may not have been thinking about hunting when it released its M1A SOCOM CQB, but that doesn't mean the rifle can't be taken afield. Let Dick Williams tell you more about this "gun for all seasons."
The M1911 Hits the Hunting Trail
Contributor Dick Williams wanted to hunt hogs with his favorite pistol, the venerable M1911. Here's how he turned the classic design into the perfect hunting rig.
The Wait is Over: Ruger's .45 ACP/.45 Colt Revolver
Ruger has added a dual-caliber big bore option to its popular Redhawk line.
First Look: Thompson/Center Strike
Dick Williams takes a closer look at the latest addition to the Thompson/Center family, the Strike.
Hardware: Ruger Single-Seven
The Ruger Single-Seven (offered exclusively through firearm distributor Lipsey's) has the same frame size as the older rimfire Single-Six, but it is chambered in .327 Federal Magnum. Except for the sights, all the visible metal is stainless steel. The laminated hardwood grips have an orange tint and a Ruger medallion inset.
First Look: Smith & Wesson Bone Collector
Smith & Wesson's Performance Center has rolled out the 460 "Bone Collector." Here are three things you need to know.


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Ladakh, Land of High Mountain passes, virgin beauty of iridescent lakes, and boast of unparalleled beauty – a wonderful place to witness the unmatched beauty of nature with a lunar landscape. Trip to Leh Ladakh must certainly be in your travel list if you're looking to venture out in the lap of the Mother Earth. Explore the historical and contemporary attributes of Ladakh like Pangong Lake, stroll the banks of Indus & Zanskar rivers, admire snow-capped peaks and enjoy folk dance show. Colourful Tibetan monasteries, pristine lakes, steep Mountains, a vibrant culture, numerous trekking trails, and the rugged terrain await you in these mystic lands.
Union Territory of Ladakh is divided into two districts of Leh and Kargil. Leh is the largest town in Ladakh, an epitome of scenic beauty and one of the major attractions in the Leh Ladakh trip. Leh is a great tourist attraction because of its picturesque locations, beautiful monasteries and interesting markets defining the culture of the place. The most popular time to visit Leh Ladakh is from May to end of September.
Known as the 'Heaven on the Earth', Jammu & Kashmir is the place where Mother Nature has endowed all her love. Kashmir is world famous for its snow-capped mountains, scenic splendour, plentiful wildlife, alpine meadows, houseboats, hospitable people and local handicrafts. Enclosed by the Himalayas and Karakoram ranges; Jammu & Kashmir is even home to the popular Hindu shrines like Shri Mata Vaishno Devi and Baba Amarnath Cave. The majestic valleys of Kashmir offer adventure activities such as golfing, skiing, trekking, paragliding, fishing, river rafting, Kayaking and camping. The serene destination also provides unique experiences to its tourists in the form of spicy native food along with a stay at a houseboat or Shikara ride on Dal and Nigeen Lake.
In our "Plan My Trip" section you can submit your customized travel plan and our team of qualified professionals will do their best to meet your expectations. We have Leh Ladakh and Kashmir tour packages starting from 3 nights and 4 days up to 14 nights and 15 days. Besides Ladakh and Kashmir tour packages, you can also check out our list of accommodations available in Kashmir and Ladakh.
LehLadakhKashmir.in is a popular Ladakh and Kashmir travel agency which provides you the solution for all your inquiries about this paradise. Kashmir and Leh Ladakh can be best explored with fully organized, well planned, and customizable Kashmir and Leh Ladakh tour packages from LehLadakhKashmir. Our long association with direct vendors allows us to quote rates that are hard to match by other travel agencies and due to this we ensure the best deals for our clients.


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More than two dozen students were on a school bus when it collided with a car and crashed into an Indianapolis pawn shop Tuesday morning, authorities said.
None of the 26 students from Arsenal Tech were injured in the 6:50 a.m. crash, WXIN reported. The driver and an adult monitor also were unhurt. The driver of the sedan involved in the crash also was not injured, WRTV reported.
According to the Indianapolis Metropolitan Police Department, the bus was heading east on East 16th Street and the sedan was heading west when both vehicles turned south onto Emerson Avenue and collided, WXIN reported, The impact of the crash sent the bus into a Cash America Pawn store, the Indianapolis Star reported.
The school bus was pulled out of the building safely, WTHR reported.
UPDATE 3 | The school bus that hit a pawn shop has been pulled out safely. @WTHRcom pic.twitter.com/79AgdSKNeM— Frank Young (@FY3TV) October 22, 2019
About the Author


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When I was a GM for Cracker Barrel, I made several trips East and West on I-40, passing through Arkansas on my way to and from my home store in Norman, OK.
I was obviously preoccupied, probably something-or-other job related, I'm sure. But this morning, as we hit the freeway, I got a chance to really look at the state.
It is gorgeous.
Green rolling fields and hills carpeted with thick, bountiful trees as far as the eyes can see. I stopped at three different rest stops and scenic views and I told Karen I wouldn't mind living in one of them, THAT is how cool Arkansas is.
The only thing I can think of that gives me slight pause is a movie I once watched. It was about gruesome mayhem and torture with blood, guts, horror and maniacal butchery. Cannibalism was also commonplace as was unspeakable acts of depravity.
It was refreshing to see fat, hydrated cows cooling in the shade of the trees, or one of the beautiful creeks that flow through the ranch.
Just like in the children's books.
So, moving eastward, we pass Lake Dardanelle, and it was beautiful when we drove by. I could very much envision myself in a boat on the water with a big fat doobie to assist with the navigation.
Arkansas is also home to the Razorbacks, and license plates with the red porkers were evident on both sides of the freeway. So were the red and white flags.
I really knew I was officially in Arkansas when two fans flipped me off after spying my Notre Dame license plate holder.
I used to love the Arkansas men's basketball team when Nolan Richardson, their head coach, had them delivering "40 minutes of hell" on defense and winning the national championship in 1994.
Another thing about Arkansas is that I have probably interacted and spoken with 7 Arkansans (so far), and every single one of them are polite and amiable.
Very hospitable.
Again, if it were only closer to Karen's sisters.
So, tomorrow we continue the journey, I think stopping somewhere in Indiana or Illinois.
Then the last leg will be to our destination, the Queen City of Cincinnati.
My beautiful dogs are straining our last nerves as they feel the need to protect the parameters of wherever we are staying.
The sky poked its head through the tufts of lazy clouds. It was baby blue, and of course, reminded me of the devastating George Strait song. This led to me blasting a bowl of Tropical Punch with its 28% THC content and then I played one of The Man's other songs. I will def be posting Baby Blue at some time in the future as it is an awesome song. I probably play about six or seven George Strait tunes and I could probably figure out a half-dozen others.
So, for now, take a listen to my rendition of Baby's Gotten Good at Goodbye and let me know.
Stay well.


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Archie Action #7
Yaffa Publishing Group Pty. Ltd.
Issue contents
Cover Untitled (Archie) Cover, 1 page
"Reggie has only two faults, Betty…"
- Feature
- Archie
- Genre
- Humour
- Art
- Stan Goldberg, penciller
- Jon D'Agostino, inker
- Colours
- , colourist
- Text
- Bill Yoshida, letterer
- Editing
- Richard H. Goldwater, original Editor
Reprint history
- First print
Archie's TV Laugh-Out (Archie, 1969 series) #68 (July 1979) — Untitled
- Also printed
Archie Action (Yaffa Publishing, 1980? series) #4 ([October 1985?]) — Untitled
The colouring on this cover is very different to the original colouring by Barry Grossman.
The indicia for this issue is not recorded. The identified publisher might be an associated or parent company, rather than the specific listed publisher.
Comments, updates, corrections and suggestions
Contributions about Australian comics are welcome. Comments will be moderated. Spam, trolling, abuse and off-topic comments will not be publicly displayed.
New posts are visible only until you leave this page. They become public when approved. Read previous comments here.
If you post in error, email via the contact link below.


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Assam TET Syllabus 2023, Check ATET LP UP Exam Pattern PDF:- Candidates who are preparing for ATET LP & UP Exam can access Assam TET LP UP Exam Syllabus 2023 here. The Assam TET Syllabus 2023 will help aspirants to prepare for their Teacher Eligibility Test. Aspirants can access Assam TET 2023 Syllabus PDF available our site for candidates. Applicants can download Assam Teacher Eligibility Test Syllabus 2023 and start preparing for exam. Participants can get ATET LP UP Syllabus & Exam Pattern 2023 information from below.
Assam TET 2023 Hall Ticket Download
असम टेट सिलेबस & परीक्षा पैटर्न (Assam TET Syllabus & Exam Pattern) पेपर 1 और पेपर 2 के लिए यहां पर उपलब्ध है. Assam TET 2023 की तैयारी के लिए ये सिलेबस और एग्जाम पैटर्न बहुत महत्वपूर्ण है-
Assam TET Syllabus 2023
The Elementary Education, Govt of Assam has released Assam TET 2023 Syllabus. Applicants can download RMSA ATET Paper I Syllabus Subject Wise. The Assam TET Paper II Syllabus Pattern 2023 help in exam of Assam Teacher Eligibility Test. Aspirants who are searching Assam TET 2023 Notification and start their exam preparation to qualify this written exam then they can access their written exam pattern. We have provide Assam TET Syllabus 2023 PDF. Our Team has provide various subject syllabus like as Child Development and pedagogy, Language I & II, Mathematics, Social Science and many more. Candidates may practice previous year papers of Lower Primary & Upper Primary also.
RMSA ATET Exam Syllabus 2023 Download
The Department of Elementary Education, Assam has upload TET Syllabus 2023 PDF in Assami. The Elementary Education, Govt of Assam releases official update regarding Assam TET Exam Syllabus 2023. So stay aware and make continue exam preparation. This exam consist various subject in RMSA ATET 2023 Syllabus PDF. We have provide below complete exam pattern & syllabus PDF. Eligible Aspirants check complete Subject ATET Assam Teacher Eligibility Test Syllabus in PDF format.
@ssa.assam.gov.in TET Syllabus 2023 Details
|Exam Conducting Authority
|The Department of Elementary Education, Assam
|Exam Name
|Assam Teacher Eligibility Test (Assam TET)
|Assam TET Exam Date
|Announce Soon
|Job Location
|Assam State
|Official Site
Minimum Marks for Qualifying in TET
|Sr. No.
|Marks (Out of 150)
|60% (90 Marks)
|SC/ST (Hills)/ST (Plain)/OBC/MOBC/PWD (PH)
|55% (83 Marks)
Exam Pattern of Assam TET 2023
The Paper I will be for a person who intends to be a teacher for Lower Primary level (classes I to V)
Paper I Lower Primary (for classes I to V):
Structure and Content (All Compulsory)
|Sl. No.
|No. of Questions
|Child Development & Pedagogy (compulsory)
|30 MCQs
|30 Marks
|Language I – Assamese, Bengali, Hindi, Bodo, Manipuri, Garo, Nepali, Karbi, Hmar (compulsory-any one)
|30 MCQs
|30 Marks
|Language II – English(compulsory)
|30 MCQs
|30 Marks
|30 MCQs
|30 Marks
|Environmental Studies
|30 MCQs
|30 Marks
- All(150) questions will be of MCQ type; each question will carry 1 mark.
The Paper II will be for a person who intends to be a teacher for Upper Primary level (classes VI to VIII).
Paper II Upper Primary –Mathematics & Science or Social Science (Studies) (for class VI to VIII):
Structure and Content:
|Sl No
|No. of Questions
|Child Development & Pedagogy (compulsory)
|30 MCQs
|30 Marks
|Language I – Assamese, Bengali, Hindi, Bodo, Manipuri, Garo, Nepali, Karbi, Hmar (compulsory-any one)
|30 MCQs
|30 Marks
|Language II –English (compulsory)
|30 MCQs
|30 Marks
|4. (a)
|For Mathematics and Science teacher : Mathematics and Science Or
|60 MCQs
|60 Marks
|4. (b)
|For Social Studies teacher : Social Studies Or
|60 MCQs
|60 Marks
|4. (c)
|For any other teacher – either iv (a) Or iv (b)
- All(150) questions will be of MCQ type; each question will carry 1 mark.
- There will be no negative marking.
- Duration of examination: 2 1/2 hours (150 Minutes) for Paper-I and 2 ½ hours (150 Minutes) for Paper II. Additional 20 minutes' time (per hour) will be there for visually impaired candidates.
Certificate Validity:
The validity of Mark sheet cum Certificate of TET shall be for 7 (seven) years from the date of issue of the certificate by the Empowered Committee, TET, Govt. of Assam.
Assam TET Lower Primary/ Upper Primary Syllabus 2023 PDF
The syllabus for Paper- I & Paper II is as given below-
Important Links:-
|Assam TET Online Form
|Click Here
|ATET Exam Admit Card
|Download Here
|Assam TET Result
|Check Here
|Official Website
|Click Here
Download Assam TET Syllabus 2023 LP UP
Applicants are suggested to refer official RMSA ATET Exam Pattern 2023. Examination Board prepare written exam paper from Assam TET Syllabus 2023 only. Aspirants can check details of Assam TET Exam Pattern 2023. If you have query then comment us.


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PayPal Introduces New Super Application For Consumers
PayPal is one of the largest digital payments services providers in the world. The USA-based company has been known and favoured by freelancers and international entrepreneurs around the globe. With PayPal, users can send money from one part of the world to another from the comfort of their homes.
These days the online payments giant is going through a major transitional period due to the ongoing cryptocurrencies trading. In July this year, the company representatives told the media about the launch of a new super application for their users. This new application is going to be able to combine both crypto and non-crypto-based payment with a single wallet address and account.
Savings Account Facility
CEO Dan Schulman recently shared an update on the development and launch of the new super application by PayPal. He told the media that in the beginning, the application was going to be available for the consumers in the United States only. He also announced the partnership of PayPal with Synchrony Bank for adding the high yield savings accounts.
A high yield savings account usually claims to pay 20%-25% more in comparison to the traditional and central financial custodians. PayPal CEO revealed that the users would be able to earn 0.40% yield per annum on with their savings. The users will also have the option to withdraw their yield income to their main account and use it for purchases.
PayPal authorities have told media that the new super application is going to be filled with many new features such as rebate, custody, cashback, bill payments, online money transfers, remittances, and even direct deposits. All of these services are going to be effective for both crypto and fiat currencies.
PayPal has recently introduced crypto trading services in the United Kingdom. The payments giant is also planning to integrate features like QR code-based payments as well. The biggest transition in the super application is going to be the option of crypto and forex trading for users all over the world.


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Net cafe refugees (also known as cyber-homeless) is a term for a growing class of homeless people in Japan who do not own or rent a residence and thus have no permanent address and sleep in 24 hour Internet cafés or manga cafés. Some internet cafes offer free showers and sell underwear and other personal items, enabling net cafe refugees to use the internet cafes like a hotel or hostel.
A Japanese government study estimated that over 5,400 people are spending at least half of their week staying in net cafes. It has been alleged that this phenomenon is part of an increasing wealth gap in Japan, which has historically been a very economically equal society. Another word for Net cafe refugees is Cyber-homeless, a Japanese word based on English. Typically, the cyber-homeless are unemployed or underemployed and cannot afford to rent even the cheapest apartment, which is more than the cost per month to rent an internet booth daily. The cyber-homeless may use the address of the internet cafe on resumes.


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Rental proposal
Proposal data
- Estimated monthly rental
- HKD $32,075 /month
- at HKD $ 13 /sq. ft.
- Area
- 2,566 sq. ft.
- Zone
- Mid Floor
- Located approximately on middle floor level of the building.
- View
- Building View
- Property with prominent view of neighbouring buildings, external street activities may be visible when viewing out the windows.
- Usage
- Industrial / Warehouse
- A place for production, storage, handling, design, development, processing, etc. of goods and materials.
- Renovation status
- Bare shell
- A premises with basic building services, usable space for self customisation according to preference and need.
Proposal date: • Reference ID: 1050754
Building details
Cambridge Plaza (劍橋廣場)188 San Wan Road Sheung Shui
Cambridge Plaza (劍橋廣場) is a grade-B building located at 188 San Wan Road (新運路) in Sheung Shui district. This is a 6-storeys building for Industrial \ Warehouse use, offering a range of industrial \ warehouse property spaces that suit various business needs.
This building is accessible by alighting at Sheung Shui (上水) MTR train station.
For air-conditioning, this building mainly uses independent a\c air-conditioning, giving tenants the flexibility to control air-conditioning supply on-demand.
- Building grade
- Air-conditioning
- Independent A/C
- Nearest MTR station
- Sheung Shui


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https://treatcancer.com/wp-content/uploads/2018/05/1688_42274377349_3260_n.jpg 208 604 admin https://treatcancer.com/wp-content/uploads/2021/05/logo-base.png admin2018-05-08 15:01:522021-07-27 17:31:59Physician Research Selected for 2018 ASTRO Annual Meeting
Physician Research Selected for 2018 ASTRO Annual Meeting
Three abstracts from physician research have been selected for the 2018 American Society for Radiation Oncology (ASTRO) Annual Meeting this fall in San Antonio, TX from October 21-24. Two of the abstracts will be oral presentations. The meeting is the premier radiation oncology scientific event in the world.
ASTRO is the largest radiation oncology society with over 10,000 members. Learn more about ASTRO here.


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Garden Variety IS the Spice of Life!
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The United States saw its 2022 World Cup dream come to an end on Saturday with a 3-1 loss to the Netherlands on Saturday. Fans of the USMNT are rightfully crushed to see their team go home after a dramatic push to reach the round of 16 for the first time since the 2014 World Cup.
It's a long time until Americans will see Gio Reyna, Christian Pulisic and Co. in World Cup competition in 2026. If they need something to cheer them up, Waffle House is here to help.
Now, Amsterdam, the capital of the Netherlands, is one of the world's great cities. The country features stunning tulip fields and miles of cycling routes. At the Mauritshuis Royal Picture Gallery in The Hague, visitors can see Johannes Vermeer's masterpiece "Girl with a Pearl Earring."
However, at none of those places can you get hashbrowns scattered, smothered, covered, chunked, diced, peppered, capped or topped.
Waffle Houses-— Waffle House (@WaffleHouse) December 3, 2022
Netherlands: 0 #FIFAWorldCup
So while the Dutch soccer team moves on and seeks to win its first World Cup title, Americans will just have to drown their soccer sorrows in maple syrup.


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Vacation rentals in Perticano
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Perticano
Guests agree: these stays are highly rated for location, cleanliness, and more.
Rental unit in Gubbio
Villa Iole - In the heart of the Middle Ages
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$90 per night
Cabin in Cerreto d'Esi
Stone and wood hillside chalet.
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Relax with the whole family in this peaceful accommodation. Accommodation immersed in the greenery of the Monte Cucco Regional Park. The apartment in question is located on the first floor in a fully fenced private property with independent access and private parking space. Guests will have the opportunity to use the outdoor spaces and all its services.
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Crowsnest Twitter
- RT @ECGreenway: We were thrilled to welcome this impactful group of 18 new designations in 11 states to the East Coast Greenway in 2022! L… 7 hours ago
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#PBL InstagramOn Tuesday January 26th, from 7:00-8:00pm, the Suffield Historical Society will host a free Zoom program with Elizabeth Normen, author of Venture Smith's Colonial Connecticut, a new book for middle schoolers and about the founding of Connecticut as told through the 1798 first-person narrative of Venture Smith. She will speak about this new approach to understanding that the story of Connecticut's founding is the story of three primary groups of people: Native Americans, Europeans, and African/African Americans. She will also share research by scholars that has added to Smith's narrative, providing rich details about his later life in Haddam Neck and our understanding of the complexity of the colonial economy.
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Great Information Wrapped Inside This Human Struggle
Please view this EdPuzzle for which I did not make any questions. I just want to help you find a topic for this colonial unit where I am asking you to step up and become an American literary critic. https://edpuzzle.com/embed/m/55f9b2dd595a772936a046a4 … Continue reading
Colonial Literature paragraph
Although it was very those days complicated there was one thing that was really important for American people back then – the faith in god. There is a stereotype that America was the land of religious freedom that's why lots … Continue reading
Posted in Colonial Literature, English III Tagged Anne Hutchinson, Colonial Literature Leave a comment
Anne Hutchinson
For my Counter Cultural Figure, I chose Anne Hutchinson. Anne Hutchinson was brought to trial for going against the beliefs and teachings of preachers in the town. During her trial, she stepped out of the expectations of women of the … Continue reading
Posted in American Literary Studies, Feminism, Honors English III Tagged Anne Hutchinson, Counter Culture Figure, Feminist, Trial 2 Comments


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We are a computational research group at the Institute for Computational Cancer Biology Cologne (ICCB) at the University of Cologne and the Berlin Institute for the Foundations of Learning and Data (BIFOLD) at the TU Berlin.
Cancer genomics and evolution
Our lab develops and applies algorithms and computational methods to understand how cellular and intra-tumour heterogeneity (ITH) arises and how it affects tissue and patient phenotypes in space and time. We are particularly interested in chromosomal instability (CIN) and somatic copy-number alterations (SCNA), a key characteristic that separates cancerous from healthy somatic tissue. In our methods we leverage statistical and machine learning approaches as well as classical computer science algorithms and simulations and develop these models in close collaboration with our experimental partners.
Specifically, we are active in three research areas:
- Structural evolution of cancer genomes, where we conduct retrospective studies to infer cancer evolution from clinical patient samples and forward simulations that enable us to investigate cancer growth and evolution in-silico
- Interpretation of genetic variation, where we leverage machine learning and statistical genetics approaches on large cohorts to understand cancer gene regulation and epigenetics
- Early detection and prevention, where we work on population-based molecular biomarkers and patient risk stratification.
Our work bridges theoretical and applied biomedical research and we develop, train, and validate our methods on large clinical datasets as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG), ICGC-ARGO, and the TRACERx Consortium as well as several smaller consortia.
Our main location is at the University Hospital Cologne in the vibrant, international city of Cologne, Germany.
We are also maintaining a branch at the Berlin Institute for the Foundations of Learning and Data (BIFOLD) in the German capital of Berlin.
Keep an eye on our recruitment page for job openings at either location.
November 14, 2022
MEDICC2 manuscript published in Genome Biology!
Eight years after its intial release we are more than proud to announce that the MEDICC2 algorithm and paper for inferring cancer evolution from somatic copy-number alterations is now published online at Genome Biology.
MEDICC2 is the leading algorithm for phylogenetic reconstruction from and quantification of chromosomal instability. It is based on an efficient finite-state transducer framework which, together with integrated parallelisations, allows accurate phylogentic inference even for single-cell data with thousands of cells.
MEDICC2 not only outperforms the original implementation in speed by orders of magnitude, but also, as the first and only algorithm in the field, allows the accurate detection of clonal and subclonal whole-genome doubling events.
November 9, 2022
Welcome to our new lab members!
The Schwarzlab is welcoming several new members to our group at our site in Cologne at the ICCB!
Daniel Schütte is a clinician scientist who is interested in molecular biomarkers and cancer early detection and prevention and already joined some months ago.
Felix Schifferdecker and Selina Wächter are two MD students who will be writing their dissertation in the lab in parallel to their MD coursework and clinical pratice over the next years. Felix will be working on simulating chromosomal aberrations in cancer evolution and Selina will be investigating methods for detecting selection in cancer phylogenies.
Finally, we would like to welcome Teodora Bucaciuc, who has joined the lab as a research associate, developing pipelines for copy-number analysis and investigating the co-evolution of genomic and epignomic alterations in cancer. Welcome all, great to have you on board!
October 21, 2022
Julia Markowski successfully defends her PhD
We are incredibly thrilled that Julia Markowski successfully defended her PhD on October 21, 2022 at the Berlin Institute for Molecular Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association.
Her PhD thesis is titled "Inferring haplotype-specific chromatin conformation using Genome Architecture Mapping" and she will receive her PhD from the Humboldt University Berlin in the near future.
After completing her Masters degree in Bioinformatics at the Max-Planck-Institute for Molecular Genetics and the University of Potsdam, Julia joined our lab in May 2017 on a MDC PhD Fellowship. She was subsequently supported by the DFG priority programme SPP2202 "Chromatin Architecture in Health and Disease".
She is now moving to Boston as a postdoctoral fellow in the Park Lab at Harvard Medical School and we wish her all the best for the future!
Key publications
Kaufmann T, Petkovic M, Watkins TBK, ..., Van Loo P, Haase K, Tarabichi M, Schwarz RF. MEDICC2: whole-genome doubling-aware copy number phylogenies for cancer evolution. Genome Biology (2022).
▶ MEDICC2 is the leading method for inferring cancer evolution from somatic copy-number alterations. It identifies individual evolutionary events and detects whole-genome doubling. Published only eight years after MEDICC! Second best acronym ever.
Markowski J, Kempfer R, ... , Kehr B, Pombo A, Rahmann S, Schwarz RF. GAMIBHEAR: whole-genome haplotype reconstruction from Genome Architecture Mapping data. Bioinformatics (2021).
▶ GAMIBHEAR is a novel algorithm for inferring chromosome-spanning haplotypes from Genome Architecture Mapping data. It provides the basis for accurate haplotype-specific chromatin contact maps in human. Best acronym ever.
PCAWG Transcriptome Core Group, Calabrese C, Davidson NR, Demircioğlu D, Fonseca NA, He Y, Kahles A, ...,
Brazma A*, Brooks A*, Göke J*, Rätsch G*, Schwarz RF*, Stegle O*, Zhang Z*. Genomic basis for RNA alterations in cancer. Nature (2020).
▶ In the PCAWG consortium we investigated the allele-specific effects of somatic mutations on gene expression as part of PCAWG Working Group 3. Another interesting acronym story.
Watkins TBK, Lim EL, Petkovic M, Elizalde S, Birkbak NJ, Wilson GA, Moore DA, ..., Schwarz RF*, McGranahan N*,
Swanton C*. Pervasive chromosomal instability and karyotype order in tumour evolution. Nature (2020).
▶ In this seminal paper we used the reference phasing algorithm we developed to detect parallel evolution across human cancers in the largest multi-region sequencing dataset to date. Go refphase!
Jamal-Hanjani M, Wilson GA, McGranahan N, Birkbak NJ, Watkins TBK, Veeriah S, Shafi S, ..., Schwarz RF, et al.
Tracking the Evolution of Non–Small-Cell Lung Cancer. N. Engl. J. Med., 376(22):2109–2121 (2017).
▶ In this work, we developed and contributed the reference phasing algorithm to the TRACERx consortium, which lead to the detection of mirrored subclonal allelic imbalance events (MSAI). #notmyacronym
Meet the Team
Group Leader
Prof. Dr. Roland F. Schwarz
Computer scientist by training. Lover of formal grammars, Markov models and phylogenetic trees.
Quote: "What if it's a Markov chain?"
Postdoc / Scientific Programmer
Dr. Adam Streck
Computer scientist by training. Modelling the world through cellular automata and stochastic processes. Gamer at heart, living the VR hype. Author of SMITH. Master of Technology.
Clinician Scientist
Dr. Daniel Schütte
Medical doctor and computer scientist. Improving patient care through early detection and better stratification.
PhD Student
Maja-Celine Stöber
Biomathematician. Fond of single-cell data analysis and extrachromosomal DNA. Master of Journal Club.
Quote: "No, Roland, you cannot skip Journal Club."
PhD Student
Tom L. Kaufmann
Physicist by training. Fan of deep learning and mutational processes shaping copy number. Developer of MEDICC2 and refphase. Master of Lab Meeting.
Quotes: "Oups.", "This is funny..."
PhD Student
Victoria M. Dombrowe
Knower of Molecular Medicine. Now mapping the epigenome and its evolution. Master of Events.
MD Student
Felix Schifferdecker
Medical student and computer scientist. Simulating cancer evolution and structural alterations.
MD Student
Selina Wächter
Medical student. Learning how to code, getting into Bioinformatics.
Research Associate
Teodora Bucaciuc
Biologist and Bioinformatician by training. Interested in genomics and the co-evolution of genome and epigenome.
Visiting Scientist
Dr. Tom Watkins
Physician by training. Chromosomal instability and somatic copy-number alterations.
From the Swanton lab, Francis Crick Institute.
Lab mascot
Fierce winged unicorn. Destroyer of bugs. Defender of students. Do not mess with Quark.
Quote: "No, I'm not a pegacorn."
CRUK - TRACERx
We are part of the CRUK funded TRACERx consortium lead by Charles Swanton at the Francis Crick Institute in London where we contribute algorithms for phasing of copy-number alterations and phylogenetic tree inference.
In ICGC-ARGO we are part of the data coordination and management group and are leading a project that contributes pipelines for allele-specific expression analysis.


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Saturday, April 14, 2012
I did not dare to post yesterday - Friday the 13th. Anyway, some heavy metal art from school days here. This one was done Spring 1992, at that time I had not heard Mayhem music yet nor seen any pictures of the band (hey, when Mayhem gave first interviews in 1986 they did not have any own music recorded either!). It was around the time when I read about Mayhem from C.O.T.I.M. fanzine that their singer "Dead" had commited suicide. I mean it was quite shocking. So far I knew only two other Metal related deaths (Cliff Burton of Metallica (bus accident) and Roger Patterson of Atheist (car accident)). But I loved this winged logo and satanic symbols. Up to today I think that this Mayhem logo is brilliant (other pretender to the throne is Morbid Angel logo). So this unknown guy Nella must have had good imagination when he drew this Mayhem logo in 1986!
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Sentencing has been delayed for a Manhattan man convicted last month of attempted voluntary manslaughter.
Mark Harrison was due to be sentenced Monday, but according to Riley County District Court Administrator Lanna Nichols that hearing was postponed for another week. Harrison entered a no contest plea in June to the charge. He had previously been convicted of criminal damage to property.
Harrison had originally faced a capital murder charge involving a police officer, of which he was set to go on trial for in early August. A previous trial ended in a hung jury in February. Prosecutors said he fired 33 shots during the three-hour standoff in January 2018.. One of those shots injured RCPD officer Pat Tiede.
Harrison's new sentencing hearing is set for 9 a.m. July 29 in front of Judge Grant Bannister.