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Jessi Miller Bradley • about 10 years ago
Looking for Boston-Based Robocall Ideas
I'm a producer at CBS in Boston (WBZ-TV) and I'd like to interview someone in the Boston-area who thinks they've found a way to deal with Robocalls. Please give Jessi a call at 617-787-7381. Thanks!!
2 comments
Marny Smith Manager • about 10 years ago
Hi all,
Just wanted to let you know that ChallengePost and the Federal Trade Commission will not give preference to any submitter who responds to, or participates in any interview. Participating in any interview will not influence how a submission is scored or a submission's chances of winning a prize. Please contact email@example.com with any questions.
Phillip Hallam-Baker • about 10 years ago
I am based in the Boston area.
You can see an overview of my solution at:
The bit with the daleks is to explain that just solving the problem of robocallers is not enough, most of the solutions being proposed create a bigger problem than the one they are trying to solve. You can't solve the problem of robot callers by having a robot intercept every (or even most) telephone calls.
There is a lot of experience in dealing with email spam that is relevant to the problem however. Most importantly the fact that this problem cannot be solved by just one clever idea. The bad guys also have clever ideas. What we need is a clever idea factory.
Comments are closed.


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Heroine No. 1
For quite a while now this Heroine has been in news though not necessarily for the right reasons. From size zero to adding flesh not only around bellybutton but also legs and arms as well; criticism for taking potshots at rival Katrina Kaif in the end-September release, Madhur Bhandarkar's Heroine in which she had replaced Aishwarya Rai after news of her pregnancy had made headlines; protests pouring in for the dialogue from the same film—"Heroine Dubai gayi toh uska rate card ban jata hai" (When a heroine visit Dubai, people create a rate card for her); from her now-on now not-so-on marriage to current beau, the new Nawab of Pataudi on whose head the crown seems to have become a bane rather than a boon and after Agent Vinod even Cocktail has been declared run out in the bouncy box office ticket wicket.
Media has tended to describe 'controversy' as her middle name. Controversies have chased her like a shadow in her rise to the enviable slot. Dubbed arrogant Kapoor when she made her debut opposite Abhishek Bachchan in JP Datta's Refugee (2000), she was severely criticised for her overbearing attitude which she sought to clarify as 'confidence'. She was summarily shown the exit door by Karan Johar when she demanded higher price, and billing for Kal Ho Naa Ho. Later, in his television show, she described rival Priyanka Chopra as no actress, but soon covered tracks subsequently. She tried to cover up her dalliance with Shahid Kapoor until one caught her kissing him in a restaurant. She vehemently denied, calling it morphed.
The publicity posters of Kurbaan displayed her bare back with the new man in her life, Saif Ali Khan which prompted a political party to gift her a saree to cover her up. Mercifully, she hasn't denied her live-in relationship with Saif, and their association has been nicknamed Saifeena. Lately, her seen smoking in the poster of Heroine has opened up yet another can of worms. And last, but not least her losing out Sanjay Leela Bansali's Ram Leela because of her impending marriage, and the maker's stand that a married heroine will harm his ambitious venture. Her forthcoming starrers include Heroine and Talaash with Aamir Khan.
A fourth generation scion of Bollywood's first family that has dominated the Hindi cinema scene for the last eight of the ten decades of its existence, Kareena had stardom in her genes, and natural grooming during growing-up years under the glittering sky on earth. The patriarch Prithviraj Kapoor had made his acting debut in a silent film, Cinema Girl (1929), and grandfather Raj and granduncles, Shammi and Shashi Kapoor ruling the rostrum from the early 50s to mid-80s by which time uncle Rishi had firmly established himself as a major star. For all practical reasons, Kareena's entry coincided with the exit of elder sister, Karishma (winner of a National, and four Filmfare Awards), and despite ups and downs there hasn't been a looking back as she moved from strength to strength.
Beginning with Refugee (for which she won the Best Female Debut Award) she has since worked in 41 more movies, excluding five where she made a special appearance (Kya Love Story Hai, Halla Bol, Luck By Chance, Billu, Rowdy Rathore in 07,08,09,12 respectively). She is also rumoured to be doing an item number in Dabangg 2. Nominated six times for the Filmfare Best Actress Award (Asoka, Kabhie Khushi Kabhie Gham [supporting], Omkara, Kurbaan, 3 Idiots, Golmaal 3) she lifted the coveted trophy five times Chameli (Special Performance), Dev (Critics Award), Jab We Met (Best Actress), Omkara (Critics' Award), We Are Family (Best Supporting Actress).
She had been the original choice for the Heroine role because of date problems working opposite all the Khans, one after the other, or even simultaneously: Bodyguard, Ra.One, Talaash, and home production of sorts, Agent Vinod. But once Madhur Bhandarkar was forced to scrap a major chunk done with replacement, Aishwarya Rai due to her pregnancy, the maker reverted back to the original choice who after considerable dilly-dallying agreed, one supposes, not only to bail out the troubled director but also what might turn out to be another crowning glory, though many both in the trade and outside have been seeking to describe it as her 'Dirty Picture' and her answer to Shiela Ki Jawani because she dances to the sound of Halkat Jawani. Speaking to a Bollywood News Service, she said: "Heroine is not a dirty picture. I accepted it because of its script, not to compete with anyone… It has been my dream since childhood I always wanted to be a 'heroine'. I used to listen to Madhuri and Sridevi songs on my walkman, thinking I would become an actor one day. The journey wouldn't have been complete without Bhandarkar's Heroine. I am so glad this film was in my destiny."
Replying to another query about the extent to which it is true to life, and setting aside any speculation about possible comparisons that might get singled out leading to controversy, she said: "It is fictitious; we are not portraying anybody as such. It is a biopic, but it is based on a screenplay and story he has (Bhandarkar) thought up. We haven't followed anybody in particular. My character, Mahi, is bold, edgy and aggressive, but I don't think I am like that in real life."
Over the years Kareena has emerged the favourite co-star of not only the three big Khans but also other top-ranking actors. She has starred opposite Shah Rukh in Asoka, Kabhie Khushi Kabhie Gham, Don, Billu and Ra.One Rohit Shetty has denied he is casting them together in Chennai Express; acted with Aamir Khan (3 Idiots, forthcoming Talaash); with Salman Khan (Kyon Ki, Mr & Mrs Khanna, Bodyguard), Akshay Kumar (Ajnabee, Talaash, Aitraaz, Bewafaa, Dosti, Tashan, Kambakht Ishq), Ajay Devgn (Kargil, Yuva, Omkara, Golmaal Returns, Golmaal 3); Hrithik Roshan (Yaadein, Mujhse Dosti Karogi, Main Prem ki Diwani Hoon). And, of course, four each with ex-lover Shahid Kapoor (Fida, Chup Chup Ke, Jab We Met, Milenge Milenge), and the present one, Saif Ali Khan (LOC Kargil, Omkara, Kurbaan, Agent Vinod). What more can a heroine at 31ask for: hit projects, big co-stars, dependable directors, and, of course, good mullah? Kareena has got them on a platter.
By Suresh Kohli
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subset: commoncrawl


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Eung Ha Cho and Ray Yang outlined that, according to the Clean Air Acts of 1976 and 1990, sulfur dioxide emission from coal-fired power facilities cannot exceed 1b/MBTU, which excludes any coal with higher than 0.8 wt% sulfur content. The variance for coal levels in US seams is the distribution of pyritic, organic and sulfate sulfur. With the latter being the lowest.
"Some chemical methods were developed in the past; however, none has been commercialised," the researchers said. In their study, their main objectives were to determine optimum operating conditions to maximise sulfur removal from Illinois No. 6 coal while simultaneously maintaining chlorine content within levels, and to determine the technical feasibility of bringing the technology to the commercial market.
With help from the Illinois Geological Survey, Cho and Yang collected samples of Illinois No. 6 coal, which they crushed and screened to a mesh fraction of 65x150. The samples were labelled IBC 101 and IBC 112.
The testing was conducted in a one-litre reactor that was positioned in a paraffin-oil bath kept at a consistent temperature, and each of the four necks of the device was used for a stirrer, an apparatus to reduce evaporation, a thermometer and the sample itself.
For the IBC 101 coal sample, the researchers pre-treated 20g of the sample at room temperature with concentrated ammonia hydroxide, stirred for one hour, filtered and dried under an infra-red lamp. It was then leached with hypochlorite solution under the same process.
After a portion was taken to be analysed, the remainder was hydrolysed in the same device for an hour, then filtered and dried again. After another sample was taken, the remainder began a second cycle using the same procedures.
The IBC sample was slightly different, as it was found it could not be leached above 70F due to significant loss. The researchers used this temperature to heat the leach solution, the sample was added in, then filtered and dried in the same way as IBC 101.
This sample's leaching would continue for a two-hour period. Additionally, it was treated with two leaching steps as well as hydrolysis at high pH and temperature and, after being dried, was weighed to measure weight loss.
Much like the other, a small sample was removed and the rest began a hydrolysis process; second and third cycles were repeated in the same manner.
Total sulfur was analysed according to ASTM method D3177-84, the Eschka Method. Pyritic and sulfate sulfurs were examined with ASTM D2492-84, and the organic was measured by subtracting the pyretic and sulfate measurement totals from the total.
Chlorine was also analysed, in this case using Eschka Method ASTM D2361-85, and the chlorine level of the hypochlorite solution was evaluated with ASTM D2022-64.
Several sets of experiments were conducted to find the optimum conditions for leaching and hydrolysis. "It was found that the optimum leaching should be conducted by diluting the stock solution of hypochlorite without extra addition of solid sodium hydroxide," the researchers said.
Through charting the results of IBC 101, they found that the total sulfur reduction increases as the hypochlorite of the leaching increased, and the organic sulfur followed that same pattern. However, no effects were seen in the alteration of hypochlorite concentrations or hydrolysis with regards to pyretic sulfur.
The additional cycle that the sample was exposed to also did not yield notable results. "The third-cycle desulfurisation does not add more benefit to the overall desulfurisation, particularly in terms of organic sulfur reduction and coal weight loss," they said.
The conclusion Cho and Yang drew from the set of experiments was that the leaching and hydrolysis process for IBC 101 did reduce organic sulfur significantly. "Thus this method has merits as a feasible technology for some special commercial processes for IBC 101 coal."
However, the two-step desulfurisation method for IBC 112 did not yield any significant reductions for pyritic and organic sulfur. The researchers attributed the differences in results to the samples' variations of surface total acid concentration.


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Purchase on account / installment purchase
How can I select install rates in the checkout?
Choose from the different payment options 'Buy on invoice / facture'. Make sure you enter all your information correctly and leave the mobile number. All information is used by the credit check by our financial partner PowerPay.
Purchase on account / installment purchase
When ordering on account, you have the opportunity to pay the bill completely or in installments. You decide easily only when receiving the invoice. The payment period is always 14 days. Please notice that weather When buying on account with our financing partner PowerPay work together. The entire debt collection and dunning system is handled by our partner, which also carries out an identity and credit check. Since fraudulent orders have repeatedly occurred (other delivery address, postal account), from an amount of CHF 1000.- an additional confirmation with an SMS code is necessary.
Please enter the desired payment amount in the empty payment slip. The minimum payment amount is 10% of the selling price. If you make a partial payment, you will receive an invoice every month until the total amount is settled. The open amount increases by 1% each month. The amount to be paid can be re-selected at each rate. Pro bill is also charged by PowerPay a processing fee of CHF 2.90 (Post) or CHF 1.90 (e-mail).
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Promises from God's Word Daybrightener
Promises from God's Word Daybrightener
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Listing courtesy of Keller Williams Realty Phoenix.
All information should be verified by the recipient and none is guaranteed as accurate by ARMLS. Copyright 2023 Arizona Regional Multiple Listing Service, Inc. All rights reserved.


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Despite COVID-19 pandemic, Telangana attracts Rs 6,600 crore investments
Industries secretary Jayesh Ranjan said that policies such as TS-iPASS and T-IDEA have helped in getting global companies to invest in electronics, textiles and aerospace sectors.
Published: 09th August 2021 09:39 AM | Last Updated: 09th August 2021 09:39 AM | A+A A-
HYDERABAD: Even as several States are reeling under the impact of COVID-19 for the last 16 months, Telangana has managed to attract a large number of investors from across the globe with its industrial-friendly policies, officials claim.
Though the main attraction is the State's policies like TSiPASS, T-IDEA and other similar schemes, officials say that they have helped in attracting global companies to invest in electronics, textiles, aerospace and different sectors.
According to data with the Telangana Industries Department, since the beginning of 2020, MoUs for investment of over Rs 6,600 crore have been signed and several of them have started construction work for their units.
Apart from this, several global companies have held talks with the State government evincing interest in Telangana. Already, a Canada-based company Ivanhoe Cambridge has discussed with the State to invest Rs 750 crore in the life sciences sector.
Recently, discussions were held between Telangana and Taiwan to set up the first Taiwan-specific industrial cluster in India.
Of the Rs 6,600 crore investment, the State attracted investments of Rs 2,889 crore in the electronics sector, Rs 2,855 crore in textile sector and Rs 902 crore in aerospace sector (Rs 585 crore (Azad Engineering) and Rs 317 crore (Safran Aircraft Engines).
The investments in different sectors are slated to provide direct employment to more than 34,000 people. In the electronics sector, companies like Gayam Motors, Exicom Tele systems Limited, Roshan Energy Technologies Pvt. Ltd have come forward to manufacture electric three-wheelers, two-wheelers, chargers and charging infrastructure for electric vehicles (EV), batteries and energy storage applications.
Under textiles sector, 23,000 direct jobs are coming with textile exporters such as Welspun India Limited setting up a second project at a cost of Rs 415 crore for advanced textiles project, Ganesha Ecosphere investing Rs 500 crore and Kitex Garments Limited looking to set up an apparel park at the Kakatiya Mega Textile Park in Warangal at a cost of Rs 1,000 crore.
The Korean textile and apparel company, Youngone Corporation, would be providing 11,700 direct jobs by setting up its unit at a cost of Rs 840 crore. For Kitex, which aims to offer 4,000 jobs, customised incentives are yet to be approved. The construction of these textile units are either in progress or at the beginning stage.
Speaking to The New Indian Express, Jayesh Ranjan, Principal Secretary (Industries & Commerce and Information Technology), said that the convenience of operations and factors like continuous power supply and access to resources are making investors show interest in the State.
"Our State is the only one in south India to provide trained manpower for industries. We are helping industries in every possible way to make Telangana an ideal destination for investments," he said.
While commending the high quality of infrastructure in the State, he added, "With policies like TS-iPASS, which offers speedy processing of applications for issue of various clearances required for setting up of industries at a single point, our State has become best in south India for investments."


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Jefferson County Real Estate Lawyers
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Greg Freeze
(360) 344-8100
Whittier Law SchoolCalifornia State University - Fullerton and California State University - FullertonCalifornia, Oregon and WashingtonOregon Coast Military Heritage Museum and Fountain Valley Chamber of Commerce
David J Faber
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Thomas James Ehrlichman
(425) 268-5553
WashingtonWashington State Bar Association
Gerald W. Grimes
(360) 461-7194
Columbia Law SchoolHawaii, Montana and Washington
John Augustus Wood
(360) 385-3622
WashingtonWashington State Bar
John Kenney
(360) 850-1049
University of Washington School of Law and The University of Utah S.J. Quinney College of LawBrigham Young UniversityUtah, Arizona and WashingtonUS Navy Judge Advocate General's Corps, US Navy, US Navy Judge Advocate General's Corps and Assistant Deputy Judge Advocate General of the NavyWashington State Bar and Arizona State Bar AssociationCutting Edge Asset Protection Skills and Techniques
Babak Shamsi
(425) 776-4100
Georgetown University Law CenterStanford UniversityWashingtonSnohomish County Bar Association and King County Bar Association
Boris Davidovskiy
(425) 582-5200
Seattle University School of LawCalifornia and WashingtonCalifornia State Bar and Washington State Bar Association
David C. Tingstad
(425) 776-4100
Seattle University School of LawBoise State UniversityWashingtonSuper LawyersWashington State Bar Association and Snohomish County Bar Association
William O. Kessler
(425) 776-4100
Willamette University College of LawWashingtonSuper LawyersKing County Bar Association and Snohomish County Bar Association
Richard R. Beresford
(425) 776-4100
Willamette University College of LawWashingtonWashington State Bar Association and American Bar Association
Timothy E. Steen
(425) 776-4100
Seattle University School of LawWashingtonSuper Lawyers and Super LawyersWashington State Bar Association, American Bar Association...
Christon Clark Skinner
(360) 679-1240
Willamette University College of LawPacific UniversityWashington and U.S. Supreme CourtSkagit Valley College Board of Trustees and Washington State Bar
Anne B. Bennette
(425) 776-4100
Suffolk University Law SchoolNortheastern UniversityMassachusetts, Connecticut and WashingtonWashington State Bar Association and Snohomish County Bar Association
Robert Norwood Getz
(425) 405-1300
WashingtonWashington State Bar Association
Kenneth J. Wolfley
(360) 775-7873
University of Washington School of Law and Willamette University College of LawBrigham Young University-IdahoWashingtonWashington State Bar Association
Maureen Ray
(360) 930-0637
Franklin Pierce Law CenterNew Jersey, Washington and TexasWashington State Bar Association and Texas State Bar
Jennifer Brainard
(360) 675-7860
WashingtonWashington State Bar
Peter A. Triandafilou
(206) 788-7075
New York University School of LawUniversity of PennsylvaniaNew York and WashingtonWashington State Bar
The LII Lawyer Directory contains lawyers who have claimed their profiles and are actively seeking clients. Find more Jefferson County Real Estate Lawyers in the Justia Legal Services and Lawyers Directory which includes profiles of more than one million lawyers licensed to practice in the United States, in addition to profiles of legal aid, pro bono and legal service organizations.
Researching Attorney Discipline


text: << Tuesday 15 June, 2004This page was originally published on Wednesday 16 June, 2004.Browse our archives: 12345678910111213141516171819202122232425262728293031JanuaryFebruaryMarchAprilMayJuneJulyAugustSeptemberOctoberNovemberDecember200320042005200620072008200920102011201220132014201520162017201820192020202120222023Thursday 17 June, 2004 >>Click here to read today's edition! >> WN Entertainment Search the World News Network Any Language Afrikaans Czech Danish Dutch English Finnish French German Hausa Hungarian Indonesian Italian Malay Norwegian Polish Portuguese Romanian Slovak Spanish Swahili Swedish Tagalog Turkish Advanced Search Cartoons Cybercafe Fashion Groups Internet Back to the Future Archive Feedback Site Map WN RELATED American Star Bollywood Cartoons Diva Hello Film Review Hollywood Musik FM Pop Idol REGIONAL WN Africa WN Asia WN Australasia WN Caribbean WN Europe WN Mideast WN C. America WN N. America WN Pacific WN S. America World News Weather SPORT CricketPremier EurosportsNews FootballPremier Sports News TennisChampion BUSINESS WN Economy WN Energy WN Industry WN Money WN Currency ENTERTAINMENT Media Music WN Broadcast WN Arts & Music WN Kids SOCIETY WN Religion WN Issues WN Politics LANGUAGE WN Languages SCIENCE WN Education WN Environment WN Science WN Technology Advertising Company Contact Employment Media Kit WN Links WN Toolbar Breaking News Tue, 15 Jun 2004 Cruise to fade to grey in hit man role Tom Cruise is finally showing his age in his next film. | The 41-year-old superstar will be seen with grey hair. | Hollywood's Mr Nice Guy will also be departing from his customary good guy roles by p... (photo: WorldPhotos.com) Online Ireland Celebrity Entertainment Hollywood Movies Photos P. Diddy to Go on Tour This Summer NEW YORK -- Rap mogul Sean Combs is about to assume his P. Diddy persona again. Combs has been starring as Walter Lee Younger in the Broadway revival of "Raisin in the Sun," and was recently named men... (photo: white house) Newsday Entertainment Hip Hop Hollywood Music Photos Jordan's Big Impressions The week's hottest TV news with soap queen Ann Montini | :: If you like funny man Alistair McGowan's Big Impression you'll be thrilled that a new series will feature top-shelf m... (photo: Celebrity) Skynews Celebrity Entertainment Film Photos Stars Today's best bets: Home entertainment | Here's a look at what's new on VHS/DVD: "50 First Dates" (Drew Barrymore plays a woman who has short-term memory loss and Adam Sandler plays her boyfriend); "The Station Agent" (a New Jersey man inh... (photo: File) Sacramento Bee Celebrity Entertainment Film Photos Pop Cattrall stays frisky in tamer 'Sex' episodes By STEVE MURRAY | ATLANTA -- When they heard that TBS was planning to run raunch-trimmed episodes of "Sex and the City" suitable for basic-cable viewers, some of Kim Cattrall's pals wondered if her ch... (photo: WorldPhotos.com) Cox Newspapers Celebrity Entertainment Film Photos Pop Music Classical FM Folk FM Groups Hip Hop Files Hip Hop FM Musik Review Pop Guide Pop Idol Radio Rap Radio Rock Reggae Daily Reggae Life Slum Music Soul Daily Soul Globe Radio Jazz Musik FM The Blues FM DVD & Video Video Store DVD World News Broadband DVD Film & Cinema Asia Movie News Bollywood Dream Bombay Dream World Celebrity Diva Hello Film Confidential Film News Film Review Hollywood FM Hollywood Hello Movie Hello Movie Industry Now Movie Premiere Movie Woman Premier Hollywood Television & Radio Angola TV Arabian Radio Baghdad Radio Baluchistan TV Camboadia Radio Cameroon Radio Classical FM Colombo Radio Ecuador Radio Folk FM France FM Frankfurt Radio Germany FM Haiti Radio Haiti TV Hanoi Radio Hip Hop FM KTV News MTV FM Music TV News Namibia TV Nassau TV Radio Rap Radio Rock Radio Angola Radio Bombay Radio Chicago Radio Egypt Radio Europe Radio Europe News Radio Holland Radio Hungary Radio Japan Radio Jazz Radio Koln Radio Mauritius Radio Myanmar Radio Paris Radio Philippines Radio Qatar Radio Santiago Radio Scotland Radio Turkey Radio Uruguay Radio Virginia radiowinnipeg88 Singapore Radio Television Berlin Television France Television Russia Television Tibet TV Glamour Warsaw FM Zurich TV Miscellaneous Ancient Greece Architect Guide World Book Reviews Cartoons Fashion Guide Performing Stage Manager Theatre Land WKD Top | Languages | Jobs | Archived Editions | WN Links | WN Network | © 1997-2004 World News Network | Contact our Advertising team for Advertising and Sponsorship on WorldNews.com and WorldNews Network


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Guest contribution by Eric Worrall
The Greenland government, which is currently living on handouts from Denmark, has decided not to promote the development of local oil and mineral resources due to climate change.
Greenland suspends oil production due to climate change
COPENHAGEN, Denmark (AP) – The left-wing government of Greenland, which could sit on huge oil reserves, has decided to suspend all oil exploration off the world's largest island and called this "a natural step" because the Arctic government "takes the climate crisis seriously . "
No oil has yet been found in Greenland's waters that had ambitions that hydrocarbons would be critical to helping Greenlanders achieve their long-cherished dream, the annual subsidy of 3.4 billion crowns ($ 540 million) from To cut Denmark, which currently precludes full independence.
Global warming means that the retreating ice could reveal potential oil and mineral resources that, if successfully developed, could dramatically change the fate of the semi-autonomous Danish territory of 57,000 people.
"The future does not lie in oil. The future belongs to renewable energies and in this respect we have a lot more to gain, "the Greenland government said in a statement. She "wants to take on joint responsibility for combating the global climate crisis".
Read more: https://apnews.com/article/europe-business-climate-environment-and-nature-climate-change-6ac3a74848b2cf7c89d18c348b19e3a7
In my opinion, this is rather sad news for local Greenlanders.
Greenland suffers from the world's highest youth suicide rate, endemic poverty, total lack of opportunity and rampant alcohol and drug abuse – possibly because it is mainly a state alms economy. Two thirds of the Greenland economy is based on donations from Denmark.
Promoting a real domestic mineral export economy that requires mining companies to hire locals could potentially have changed that by offering more young people pride and hope for a better future, along with a serious source of income in the private sector.
Like this:


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Meizu has started sending out media invites for its MWC event on February 28. The invite comes with a tagline 'Faster Than Ever', and latest rumours suggest the company will announce mCharge 4.0. Last year at MWC, Oppo unveiled new advancements in its VOOC fast charging technology, than introduce a new product. Meizu is looking at similar prospects this year. It is not clear whether Meizu will debut new smartphones, but that lightning sign on the invite confirms the unveiling of the new fast charging technology.
According to a Weibo leak, the new mCharge 4.0 will use a 9V/4A charge with 36W power output. The technology will charge devices at lower voltage of 9V and higher current rating of 4A. This seems identical to OnePlus' Dash Charging technology which will also uses 4A current rating. The new fast charging technology will reportedly charge a dead smartphone to full battery in just 45 minutes. It is not clear what battery capacity we are looking at, but it definitely seems to be a step in the right direction.
Meizu, the Chinese smartphone maker has changed its mobile strategy in the past few months. The company recently settled a lawsuit with Qualcomm and adopted Samsung's Exynos chipset for its flagship handset. The company recently introduced Pro 6 Plus, M5, M5 Note, and M5s - all aimed at different price segments. The new mCharge 4.0 is expected to debut first on the company's next flagship smartphone, dubbed Meizu Pro 7.
Mobile World Congress starts on February 27 at Barcelona, although most mobile manufacturers will announce their products on February 26. Nokia, LG, Samsung and Huawei have confirmed their pre-MWC events on February 26, while LG is expected to debut the flagship G6, Nokia will annnounce its comeback devices for the global market, which is highly anticipated as an emotional comeback for the much-loved Finnish company.
For more technology news, product reviews, sci-tech features and updates, keep reading Digit.in or head to our Google News page.


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When growing up, we were told to study hard and get good grades so that we can get a good job and fit into society. However, no one told us to work smart or be creative. In fact, most people believe that creativity is only for the chosen few. That it is for the artists and a God-gifted talent. We also believe that being artistic can never pay our bills, so we never bother to be creative at all. However, look around you. That is all the work of being innovative. If someone was not creative, we could not have had smartphones, tablets, computers, TV, lights, music, fun games like sloty online polska, etc.
So, What is Creativity, and How Can It Help Us Develop Our Personality?
Creativity is a process whereby we generate new ideas and concepts with originality in mind. When we teach our minds to be creative, we are opening ourselves to seeing the world differently. However, when we think we cannot develop creative solutions, we can feel unable to cope with some challenges in life. Below, we are going to check on how creativity can help develop one's personality.
Creativity Engages the Mind
Being creative means being smart. Therefore, you will have to develop perfect solutions to solve your problem, which will put your brain to work.
It Frees the Mind
Sometimes, when we tell ourselves that we cannot do something, then we find ourselves that we certainly cannot do it. But when you welcome creativeness in your life, you are freeing your mind and helping it absorb new knowledge. As a result, this makes learning even more efficient.
Creativity Helps You Accept Yourself
Being creative can make you original, and eventually, you will learn how to love and appreciate yourself even more. You won't have to worry about other people's judgments and what they are thinking about you.
Also Read: 6 Ways You Can Grow Your Creativity Using Interior Design Company
It Makes Your Life Worth Living and Fun
Thinking open-mindedly will make your life interesting. It will give you a reason to wake up each morning as you think of how to explore new ideas.
Helps You to Discover your Hidden Self
Creativity opens the doors to our minds and hearts. It brings us even closer to who we are as we recognise our hidden identity and uniqueness. Moreover, it helps us learn about our true passions and unknown talents.
Nurtures Confidence
When you have embraced creativity in your life, then you will feel good about yourself. This, in turn, nurtures your confidence, and you can be bold in the decisions you make.
Instils Curiosity
You will always be curious and willing to explore new things. If there was no creativity in our world, we could all be imprisoned, and society would be filled with close-minded people. However, once you have welcomed creativity and allowed it to be part of your everyday life, then you are opening your mind to new thoughts, ideas, and a new personality.


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Alabama Shakes pay tribute to Prince in Nashville
Plenty has already been said about the incredible - and deserved - rise of Alabama Shakes, especially in Nashville, where club audiences got to witness some of the rock band's earliest gigs. But after their latest concert in town, it's a point worth driving home again.
Five years after making their Nashville debut at a tiny local record shop, on Thursday they were playing a sold-out show on one of our biggest stages: Ascend Amphitheater. Behind them was the city's exploding skyline, in front, a crowd of more than 6,000.
It was a sight to behold for the group's frontwoman Brittany Howard, who now splits her time between Nashville and their native Athens, Alabama.
"You know, I live right down the road," she told the audience. "I've got so many family and friends I've made in Nashville. I just love it here. I just want to say, I consider you all neighbors."
Along with the skyscrapers, there was another giant hovering over them Thursday, of course. Earlier that day, the news of Prince's death had rocked the world. As the band took the stage that night, the stage lights all turned to purple, and Prince's "Let's Go Crazy" blared through the speakers.
It was a touching gesture, and one that electrified the packed house, but Howard and company really paid tribute to Prince with what followed: they played their own music.
Over the last five years (and especially with their 2015 album "Sound and Color," which just cleaned up at the Grammys) they've excelled at blurring the lines between muscular rock and slinky soul, with a sense of adventure, experimentation and supreme confidence that's rarely surfaced since Prince's heyday.
And it's hard to think of a modern performer more assured and captivating than Howard when she's on a stage.
Thursday's crowd - a striking mix, from millennials to boomers - was along for the ride. The classic soul rave-ups of "I'm Yours" and "Be Mine" were a thrill, as Howard's boundless belting reminded Nashville why she's frequently likened to Otis Redding. So were moments when they brought their the roar down to whisper ("Heartbreaker") or a steady, hypnotic groove ("Don't Wanna Fight").
When it was time to play their breakout song, "Hold On," the humble southern rock number made for the biggest singalong of the night, as well as a reminder of how much the band has grown in the last five years.
The lights turned purple once again as the band neared the end of their set.
Last year, Prince had invited the group to his Paisley Park studio in Minnesota, and sat in with the band, playing by all accounts an incredible guitar solo on their "Gimme All Your Love."
When they pulled that song out again on Thursday, Howard dedicated it to Prince.
"We lost another great treasure today," she said. "It was very unfortunate, and very sad news when we heard it. I'd like to dedicate this song right here to Prince, because this is a song that he played with us. I just want to let him know we love him, we miss him, and God bless him. May he rest in peace."
Thursday's concert was the kickoff of a U.S. summer tour that has the band playing amphitheaters and festivals through August.


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Bible Conference Regulations
Bible Conference provides many opportunities for renewal through biblical preaching, sacred music and fellowship. Although classes do not meet during Bible Conference, university expectations remain in effect. This week is unique, and we want students to be well-informed of the schedules, opportunities and responsibilities.
- Class attire is appropriate for the daytime services and when out on the campus during the day (until 7 p.m.). Formal attire (coat or tie for men and dress or skirt for women) is appropriate for the evening services. Grooming policies remain in effect.
- Recreational attire is appropriate for areas behind the stadium and Davis Field House. Casual attire may be worn on campus after the evening services.
- Students are to attend all services unless they have a permanent outreach ministry where their presence is required to maintain a ministry or unless they have a conflict with a regular weekly work schedule.
- Students who need to miss Bible Conference services should secure an exemption by Tuesday, Feb. 8 here (failure to do so by the deadline will result in a late submission infraction). Those working on campus will be excused by their work managers. Recurring chapel exemptions do not apply during Bible Conference.
- Because of heavy congestion at the start of each service, we ask that students plan to arrive and begin entering the amphitorium no later than 15 minutes before each service. Ushers will help you be seated.
- Students are advised that arriving late or missing a Bible Conference service will result in an infraction.
Social Activities
- Beginning after the 10 a.m. service on Wednesday, lawns, except those surrounding the main entrance, are open for social activities during daytime hours. Gallery Green, Palmetto Green, and the lawn beside the Student Center are open both during the day and in the evening until 10:50 p.m. through Friday, Feb. 18.
- Students may enjoy picnic meals on the lawns but may not move the outside furniture onto the lawns.
- Items may not be left on lawns or benches or in the Student Center mall or buildings during services.
- The stadium field, Field 1 (adjacent to the stadium field), and the lower fields are closed to all activity because of Bruins intercollegiate soccer practice and field care/maintenance. The sand volleyball court, the activity center, and Field 2 are open for free recreation between services until 10:50 p.m.
Meal Schedule
The Bible Conference dining common meal schedule will be available on the intranet.


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Free Resources to Succeed in the Research Challenge
Refresh your understanding of the technical knowledge needed to make it through each round, and give your team a competitive edge with our expert tips on public speaking and effective teamwork.
Featured Videos
Start by watching these free videos to gain an understanding of foundational Research Challenge topics.
Cash Flows Fundamentals
Cash Flow is one of the most important metrics in finance. This lesson helps you with the Financial Analysis section of your report.
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Learn about ESG factors, Corporate Social Responsibility, as well as SRI trends in the age of COVID-19.
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Become proficient in all aspects of share trading from Traders Attitude to Market Making to Order Execution & Settlement.
Video Topics by Research Challenge's Areas of Focus
Drill deeper into complex Research Challenge topics with these free videos and give your team a competitive edge.
Does your analysis of the industry, company, and competitors include these insights?
- Types of Risk (1:20:18)
- Economics (1:05:14)
- Cash Flow Intro (22:00)
- Financial Ratios (16:00)
- Tangible Asset Evaluation (4:34)
- Analyzing Dividends and Distributions (6:07)
Value of your security is impacted by a range of factors:
- Trading Securities (1:47:08)
- Real Options Are Valuable (2:06)
- Weighted Average Cost of Capital (WACC (26:00)
- Relative Valuation (29:00)
- Valuation Metrics for Securities (5:30)
- Efficient Market Hypothesis (EMH) (7:11)
- Leverage impact on Stock Valuation (2:47)
Did the analysis thoroughly incorporate conservation of the natural world, consideration of people and relationships, and standards for running a company?
- Suitability (1:38:31)
- Corporate Governance (21:00)
- A New World of ESG (1:00:50)
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As reported by top DUI defense lawyer Don Ramsell on May 8, 2009, an Illinois Judge has just ruled that ALL blood tests intended to be used by the state as evidence of intoxication in drunk driving cases are now inadmissible.
In a consolidation of 5 police blood alcohol DUI cases, Judge Dockery of DuPage County granted the defendants' motion to suppress the blood alcohol results in all 5 for the following reasons:
1) There are insufficient ISP Rules in place governing blood tests, such as rules for approved devices (none), device accuracy (none), methods of analysis (none), maintaining repair records (none) etc. In the absence of passage of more ISP rules, ALL blood tests are now suppressed (yes, this applies to everyone!)
2) The use of DUI kits containing povidone-iodine swabs, which are contaminated with minute amounts of alcohol, are inadmissible under both the new and old ISP rules (yes, all of the police kits have bad swabs!)
This stunning victory came after a hearing that had been ongoing for over 18 months. It involved some 45 plus exhibits, hundreds of pages of documents, plus many thousands of dollars in expert's fees and testimony.


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Antique Art Nouveau Enamel, Diamond and Natural Pearl Brooch/Pendant in 14K
A delicate design that perfectly illuminates the aesthetic of the Art Nouveau period, this antique enamel, diamond and natural pearl brooch is more than mere "Art for Art's Sake." Beautifully formed in warm yellow gold, this sensually curved design features multi-colored enamel in pastel tones and diamond accents set in white gold. In the center of the piece rests a single, natural pearl.
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Basundari provides the best environment for practicing yoga and meditating. There is a Yoga Shala and several meditation spots. Basundari also features two common pools, a café, and an upper and shared space. Next to that Basundari is surrounded by beautiful nature like rice fields and a jungle where frogs, butterflies, geckos, squirrels, dragonflies, ducks, chickens, lizards, and the rare snake may be found. The light shines through the bamboo and coconut trees as the sun rises. The path through Basundari leads to the different spaces.
The Yoga Shala is a big open and wooded place (65m2) situated among gigantic bamboo trees near the river. When it rains, a soothing waterfall cascades down the back of the Shala. It accommodates 23 yoga mats, 40 sitting yogis, or 15 aerial yogis inside. Also the Yoga Shala has blankets, blocks, bolsters, yoga mats, cushions, straps, a white board, and 15 aerial yoga hang points.
Meditation and relaxation is possible at one of the many hanging baskets or hand-shaped place. Or at the upper space deck mounted in the tree tops with beanbags.
Eating, drinking, working and relaxing can be done at the café or the shared space next to the room Villa Mewa. There are plenty comfortable spots to choose.
Food & drinks
Basundari offers delicious breakfast, lunch and dinner. A Juice Bar and many drinks are also available.
Breakfast is served as a nutritious buffet style with fresh organic fruit and vegetables, whole grains, granola, muesli, nuts, selection of dried fruits, gluten free bread for toasting, infused water, herbs, salads, boiled eggs, yoghurt, teas and coffee.
Lunch and dinner: One of Ubud's most well-known local cooks prepares vegetarian/vegan/fish or meat lunch and dinner. The menu varies daily, so you can be astonished by the incredible flavors each time. Lunch and dinner are available for an additional fee per person. A minimum of 10 persons is necessary, and they must be ordered at the time of scheduling your retreat or event..
The Juice Bar at the café offers a coconut or juices with different combinations of fruits, vegetables, spice and herbs to stimulate the taste buds and senses. The juices are perfect for a detox retreat. They'll be available to purchase until 9 p.m.
Two lovely pools are available for a refreshing swim. One is an eternity pool with views of coconut palms and rice fields, while the other has a deck looking at trees and a 4m high Buddha statue.
WhatsApp: +62 878-5329-3516
Email: email@example.com
Contact us


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Hi I'm interested in learning if there are any clever or simplified ways to store large lists of data.
One example is I'm working with storing a user's contacts and on mobile you receive a list of objects. If I'm looking to store each of these from a mobile app, would I need to make each node via its own network call? Or is there a way to upload an array and then provide instructions to access the array, thus making one network call?
I'm using neo4j-graphql-js but I guess I'm wondering in general if something like that could work


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Moderna Reports Third Quarter Fiscal Year 2021 Financial Results and Provides Business Updates
Q3 total revenue of $5.0 billion, net income of $3.3 billion and diluted EPS of $7.70
U.S. FDA granted Priority Review to the Biologics License Application for Moderna's COVID-19 vaccine
Interim data from Phase 2/3 KidCOVE study of mRNA-1273 in children ages 6 to under 12 years shows vaccine efficacy of 100% two weeks after first dose of mRNA-1273 at 50 µg dose level
First participants dosed in Phase 3 study of cytomegalovirus (CMV) vaccine candidate (mRNA-1647)
Introducing inhaled pulmonary therapeutics modality: Vertex and Moderna cystic fibrosis mRNA therapeutic (VXc-522) IND-enabling first-in-human studies ongoing
Company continues to scale with 37 programs in development, including 21 in ongoing clinical studies
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Moderna, Inc. (Nasdaq: MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, today reported financial results and provided business updates for the third quarter of fiscal year 2021.
"We are humbled to have helped hundreds of millions of people around the world with our COVID-19 vaccine and yet we know our work is not done. We will not rest until our vaccine is available to anyone who needs it, and we are working hard to ensure our vaccine is available in low-income countries with approximately 10% of our 2021 volume and significantly more of our 2022 volume going to low-income countries. It is promising to see the real-world evidence showing that the Moderna COVID-19 vaccine shows sustainably high, durable efficacy," said Stéphane Bancel, Chief Executive Officer of Moderna. "Looking ahead, we are focused on advancing the many other programs in our pipeline. We recently dosed the first participants in the Phase 3 study of our CMV vaccine. CMV is a latent virus that remains in the body for life after infection and can lead to lifelong medical conditions. We are also focused on addressing respiratory viruses in addition to COVID-19, including seasonal flu and RSV. We look forward to sharing data from the Phase 1 study of our flu vaccine candidate soon and we are preparing to start our Phase 2 study. We are also preparing to start the Phase 2/3 study of our RSV vaccine candidate. RSV causes hospitalizations and deaths in our most vulnerable populations of young children and older adults. In addition, we continue to progress our therapeutics pipeline and we look forward to clinical proof of concept data. I would like to thank the Moderna team for their scientific passion and commitment to our mission. I am more energized than ever by the impact our mRNA platform will have on human health."
Updates and recent progress include:
COVID-19 Vaccine Development
- Moderna COVID-19 Vaccine (SpikevaxTM): Received Emergency Use Authorization (EUA) from the U.S. Food and Drug Administration (U.S. FDA), and approvals by the European Commission and Swissmedic for a booster dose of the Moderna COVID-19 vaccine at the 50 µg dose level
- U.S. FDA granted Priority Review to the Biologics License Application (BLA) for the Moderna COVID-19 vaccine
- New data from Phase 2/3 KidCOVE study of mRNA-1273 in children ages 6 to under 12 years shows vaccine efficacy of 100% two weeks after first dose of mRNA-1273 at 50 µg dose level, using the Phase 3 COVE study primary case definition for COVID-19
- The Phase 1 study of next-generation vaccine candidate against COVID-19 (mRNA-1283) is fully enrolled; Moderna expects to begin Phase 2 study of mRNA-1283 soon; mRNA-1283 is being developed as a potential refrigerator-stable mRNA vaccine
Respiratory Vaccines
- Phase 1 portion of the Phase 1/2 study of quadrivalent seasonal flu vaccine candidate (mRNA-1010) fully enrolled, preparations for Phase 2 portion of the study are ongoing
- Pivotal Phase 2/3 study of respiratory syncytial virus (RSV) vaccine candidate (mRNA-1345) in older adults expected to begin in 2021; study expected to enroll approximately 34,000 participants, subject to agreement with regulatory authorities
- New combination respiratory vaccines: Moderna COVID-19 vaccine + flu vaccine candidate (mRNA-1073) and pediatric RSV + hMPV vaccine candidate (mRNA-1365)
Latent Vaccines
- First participants dosed in Phase 3 study of cytomegalovirus (CMV) vaccine candidate (mRNA-1647)
- Phase 1 study of EBV vaccine candidate (mRNA-1189) expected to start soon
- New EBV therapeutic vaccine candidate (mRNA-1195)
- Phase 2 randomized, placebo-controlled study of personalized cancer vaccine (PCV) (mRNA-4157) in combination with Merck's pembrolizumab (KEYTRUDA®), compared to pembrolizumab alone, for the adjuvant treatment of high-risk resected melanoma is fully enrolled; data readout expected in the fourth quarter of 2022
- Enrollment of the first cohort in Propionic Acidemia candidate (mRNA-3927) Phase 1/2 Paramount study is complete
- First patient dosed in Phase 1 study of Methylmalonic Acidemia (MMA) candidate (mRNA-3705)
- Investigational New Drug application (IND) open and Orphan Drug Designation granted by U.S. FDA for GSD1a program (mRNA-3745)
- Providing investigational mRNA Crigler-Najjar Syndrome Type 1 (CN-1) therapy (mRNA-3351) to Institute for Life Changing Medicines (ILCM) free of charge; CN-1 is an ultra-rare disease
- Introducing inhaled pulmonary therapeutics modality; IND-enabling first-in-human studies of Vertex and Moderna mRNA cystic fibrosis (CF) therapeutic (VXc-522) are ongoing in new pulmonary modality
Moderna continues to scale, now with 37 programs in development across 34 development candidates1, including 21 in ongoing clinical studies. The Company's updated pipeline can be found at www.modernatx.com/pipeline. Moderna and collaborators have published nearly 100 peer reviewed manuscripts.
Summary of Program Highlights by Modality
Core Modalities
Prophylactic Vaccines: Moderna is developing vaccines against viral diseases where there is unmet medical need – including complex vaccines with multiple antigens for common diseases, vaccines against latent viruses, and vaccines against threats to global public health. The Company's global public health portfolio is focused on epidemic and pandemic diseases for which funding has been sought from governments and non-profit organizations.
Vaccines against acute respiratory infections
COVID-19 vaccine development
Moderna COVID-19 Vaccine (mRNA-12732, SpikevaxTM): The U.S. FDA granted Priority Review to the BLA for mRNA-1273. The Prescription Drug User Fee Act (PDUFA) goal date for a decision by the FDA is in April 2022. The World Health Organization (WHO) and health agencies in more than 60 countries have granted emergency use authorization or emergency use listing for the use of the Moderna COVID-19 vaccine in adults.
Booster Dose of mRNA-1273: The U.S. FDA, EMA, Swissmedic and other health agencies around the world have authorized a booster dose of the Moderna COVID-19 vaccine at the 50 µg dose level.
Addressing Variants of Concern: Moderna has four development candidates against SARS-CoV-2 variants of concern, including three which have been administered in a Phase 2/3 clinical trial. The Company's strategy is to develop booster vaccines against current variants of concern and against potential future variants of concern.
- mRNA-1273.351: Variant-specific candidate against the Beta variant
- mRNA-1273.617: Variant-specific candidate against the Delta variant
- mRNA-1273.211: Multivalent candidate combining the Beta-specific variant and mRNA-1273
mRNA-1273.213: Multivalent candidate combining the Beta-specific and Delta-specific candidates
- Booster Dose of mRNA-1273: The U.S. FDA, EMA, Swissmedic and other health agencies around the world have authorized a booster dose of the Moderna COVID-19 vaccine at the 50 µg dose level.
Further Clinical Studies of mRNA-1273
Phase 2/3 "TeenCOVE" study of mRNA-1273 in adolescents: mRNA-1273 is authorized for use in adolescents ages 12 to 17 in the United Kingdom, European Union, Japan, Canada, Switzerland, Taiwan, Saudi Arabia, Australia and the Philippines. The U.S. FDA notified the Company that it will require additional time to complete its assessment of Moderna's EUA request for the use of mRNA-1273 at the 100 µg dose level in adolescents 12 to 17 years of age.
Phase 2 "KidCOVE" study of mRNA-1273 in young children: The Phase 2 study of mRNA-1273 in pediatric population ages 6 months to under 12 years is ongoing. Moderna is sharing new data from the KidCOVE study of mRNA-1273 in children ages 6 years to under 12 years. Vaccine efficacy of 100% using the P301 primary case definition for COVID-19 was observed two weeks after the first dose of mRNA-1273 at the 50 µg dose level. Additionally, for asymptomatic infection two weeks after the first dose, vaccine efficacy was 65% (95% CI: .16, .85). For SARS-CoV-2 infection regardless of symptoms, vaccine efficacy was 80% (95% CI: .62, .90) two weeks after the first dose. On October 24, the Company announced positive top line top line data from the Phase 2/3 study of mRNA-1273 in children 6 to under 12 years of age. Geometric mean ratio (GMR) comparing the response in children to the response in young adults from the Phase 3 COVE study was 1.5 (95% CI: 1.3, 1.8), with a seroresponse rate of 99.3%. Two 50 μg doses of mRNA-1273 were generally well tolerated. Moderna plans to submit results to the EMA and regulatory agencies around the world soon. Dose selection studies are underway for the 2 to under 6 years and 6 months to under 2 years age groups.
Phase 3 "COVE Transplant" study of mRNA-1273: The Phase 3 study of mRNA-1273 in adults with a kidney or liver transplant is ongoing, including the offer of a third vaccine dose to these immunocompromised participants.
- Phase 2/3 "TeenCOVE" study of mRNA-1273 in adolescents: mRNA-1273 is authorized for use in adolescents ages 12 to 17 in the United Kingdom, European Union, Japan, Canada, Switzerland, Taiwan, Saudi Arabia, Australia and the Philippines. The U.S. FDA notified the Company that it will require additional time to complete its assessment of Moderna's EUA request for the use of mRNA-1273 at the 100 µg dose level in adolescents 12 to 17 years of age.
- Next-generation vaccine candidate against COVID-19 (mRNA-1283): The Phase 1 study of mRNA-1283 is fully enrolled and ongoing. An interim analysis of data from the Phase 1 study of mRNA-1283 at three dose levels indicate that a lower dose of mRNA-1283 achieved similar neutralizing antibody responses compared to a primary series of mRNA-1273. mRNA-1283 had an acceptable tolerability profile. The Company expects to start a Phase 2 booster study in the near term. mRNA-1283 is a next-generation vaccine candidate against COVID-19 that encodes for the portions of the SARS-CoV-2 spike protein critical for neutralization, specifically the Receptor Binding Domain (RBD) and N-terminal Domain (NTD). The encoded mRNA-1283 antigen is shorter than mRNA-1273 and is being developed as a potential refrigerator-stable mRNA vaccine that will facilitate easier distribution and administration by healthcare providers.
Additional vaccines against acute respiratory infections
Seasonal influenza vaccine (mRNA-1010): The Phase 1 study evaluating the safety and reactogenicity of three different dose levels of mRNA-1010 in adults over age 18 is fully enrolled (N=180). mRNA-1010 encodes for hemagglutinin (HA) glycoproteins of four flu strains and targets lineages recommended by the WHO for the prevention of influenza, including seasonal influenza A H1N1, H3N2 and influenza B Yamagata and Victoria.
COVID-19 and flu combination vaccine (mRNA-1073): mRNA-1073 encodes for the COVID-19 spike protein and the Flu HA glycoproteins. Moderna owns worldwide commercial rights to mRNA-1073.
Respiratory syncytial virus (RSV) vaccine (mRNA-1345): At its annual R&D Day on September 9, the Company shared positive Phase 1 interim data from the older adult cohort. Moderna is preparing for a Phase 2/3 study of RSV in older adults (ages older than 60 years) and expects to begin this study by the end of 2021. The Company expects this Phase 2/3 study will be a global study conducted in locations influenced by the epidemiology of RSV and expects to enroll approximately 34,000 participants, subject to agreement with regulatory authorities. The FDA has granted Fast Track designation for mRNA-1345 in adults older than 60 years of age. RSV is the leading cause of severe respiratory illness in young children and older adults (65+). The Phase 1 study of mRNA-1345 to evaluate the tolerability and reactogenicity of mRNA-1345 in younger adults, women of child-bearing potential, older adults and seropositive toddlers is ongoing. All four cohorts of younger adults (ages 18-49 years) and all four cohorts of older adults (ages 65-79 years) are fully enrolled. There is no approved vaccine to prevent RSV. Moderna owns worldwide commercial rights to mRNA-1345.
Human metapneumovirus (hMPV) and parainfluenza type 3 (PIV3) vaccine (mRNA-1653): Moderna is enrolling seropositive pediatric participants (12-36 months of age) in the Phase 1 study of hMPV/PIV3 study (mRNA-1653). The first cohort in this study is fully enrolled. Moderna owns worldwide commercial rights to mRNA-1653.
- Pediatric RSV and hMPV combination vaccine (mRNA-1365): mRNA-1365 encodes for the RSV prefusion F glycoprotein and the hMPV F protein. Moderna owns worldwide commercial rights to mRNA-1365.
Vaccines against latent viruses
Cytomegalovirus (CMV) vaccine (mRNA-1647): The first participants have been dosed in the Phase 3 study, known as CMVictory, which is evaluating the safety and efficacy of mRNA-1647 against primary CMV infection in women ages 16-40 years. The Company will seek to enroll up to approximately 8,000 participants in the study, including 6,900 women of child-bearing potential, at approximately 150 sites globally, beginning in the U.S. Moderna has set a goal of enrolling a diverse group of U.S. participants into the study, including approximately 42% of participants who are Persons of Color. Based on the interim analysis of the Phase 2 study, the 100 μg dose has been chosen for the Phase 3 pivotal study. The ClinicalTrials.gov identifier is NCT05085366. To learn more about eligibility, visit www.CMVictory.com. Moderna owns worldwide commercial rights for mRNA-1647.
- Epstein-Barr virus (EBV) vaccine (mRNA-1189): The Phase 1 study of mRNA-1189 is expected to begin soon. EBV is a member of the herpesvirus family and is spread through bodily fluids (e.g., saliva) and contracted primarily by young children and adolescents. It is a major cause of infectious mononucleosis (IM), and associated risks to other long-term medical conditions, including an increased risk of developing multiple sclerosis by approximately 4 to 10-fold, certain lymphoproliferative disorders and cancers, and autoimmune diseases3,4. While EBV infection in early childhood is predominantly asymptomatic, primary infection in adolescence can lead to IM, which can debilitate patients for weeks to months, sometimes requiring hospitalization for serious complications. mRNA-1189 is a vaccine being developed to prevent IM, and potentially EBV infection. Similar to Moderna's CMV vaccine (mRNA-1647), mRNA-1189 contains four mRNAs that encode EBV envelope glycoproteins (gH, gL, gp42, gp220). There is currently no approved vaccine for EBV or IM. Moderna owns worldwide commercial rights to mRNA-1189.
Epstein-Barr virus (EBV) therapeutic vaccine candidate (mRNA-1195): mRNA-1195 is being developed to prevent longer term sequelae of EBV infection, which are associated with loss of immune control of EBV latent infection, creating longer-term complications. mRNA-1195 is in pre-clinical development and encodes for additional antigens than mRNA-1189. The Company expects to initially test the vaccine in post-transplant lymphoproliferative disorder (PTLD) because at least 80% of PTLD in transplant patients is associated with EBV. The Company expects to also pursue other longer-term potential indications for this vaccine, including multiple sclerosis.
- HIV vaccine (mRNA-1644 & mRNA-1574): HIV is the virus responsible for acquired immunodeficiency syndrome (AIDS), a lifelong, progressive illness with no effective cure. Approximately 38 million people worldwide are currently living with HIV with 1.2 million in the U.S. Approximately 2 million new infections of HIV are acquired worldwide every year and approximately 690,000 people die annually due to complications from HIV/AIDS. mRNA-1644, a collaboration with the International AIDS Vaccine Initiative (IAVI) and the Bill and Melinda Gates Foundation, is a novel approach to HIV vaccine strategy in humans designed to elicit broadly neutralizing HIV-1 antibodies (bNAbs). A Phase 1 study for mRNA-1644 will use iterative human testing to validate the approach and antigens and multiple novel antigens will be used for germline-targeting and immuno-focusing. A second approach, mRNA-1574, is being evaluated in collaboration with the NIH and includes multiple native-like trimer antigens. The Company expects to begin Phase 1 studies for both mRNA-1644 and mRNA-1574 in 2021.
Public health vaccines
Zika virus vaccine (mRNA-1893): The Phase 2 study of mRNA-1893 is ongoing in the U.S. and Puerto Rico. mRNA-1893 is being developed in collaboration with BARDA. Moderna owns worldwide commercial rights to mRNA-1893.
- Nipah virus (NiV) Vaccine (mRNA-1215): NiV is a zoonotic virus transmitted to humans from animals, contaminated food, or through direct human-to-human transmission and causes a range of illnesses including fatal encephalitis. Severe respiratory and neurologic complications of NiV have no treatment other than intensive supportive care. The case fatality rate among those infected is estimated at 40-75%. NiV outbreaks cause significant economic burden to impacted regions due to loss of human life and interventions to prevent further spread, such as the slaughter of infected animals. NiV has been identified as the cause of isolated outbreaks in India, Bangladesh, Malaysia, and Singapore since 2000 and is included on the WHO R&D Blueprint list of epidemic threats needing urgent R&D action. mRNA-1215 was co-developed by Moderna and the NIH's Vaccine Research Center (VRC).
Systemic Secreted & Cell Surface Therapeutics: In this modality, mRNA is delivered systemically to create proteins that are either secreted or expressed on the cell surface.
Antibody against the chikungunya virus (mRNA-1944): The Phase 1 study evaluating escalating doses of mRNA-1944 has completed. The Company anticipates publication of the full results of the Phase 1 study soon. At this time, the Company does not have plans to advance to a Phase 2 study.
IL-2 (mRNA-6231): mRNA-6231 is an mRNA encoding for a long-acting tolerizing IL-2. This autoimmune development candidate is designed to preferentially activate and expand the regulatory T cell population. The first participant in the Phase 1 study of mRNA-6231 in healthy adult participants (between 18 and 50 years of age) has been dosed. mRNA-6231 uses the same LNP formulation as mRNA-1944. The Phase 1 study of mRNA-6231 will be the first clinical demonstration of subcutaneous administration of this delivery technology. Moderna owns worldwide commercial rights to mRNA-6231.
PD-L1 (mRNA-6981): mRNA-6981 is an mRNA encoding for PD-L1. This autoimmune development candidate is designed to augment cell surface expression of PD-L1 on myeloid cells to provide co-inhibitory signals to self-reactive lymphocytes. As an initial step to addressing a range of autoimmune indications, the Company intends to pursue proof-of-concept in a Phase 1 study of mRNA-6981 in type 1 autoimmune hepatitis (AIH), a condition that involves liver inflammation and can lead to cirrhosis and liver failure. mRNA-6981 uses the same LNP formulation as mRNA-1944. Moderna owns worldwide commercial rights to mRNA-6981.
- Relaxin (mRNA-0184): mRNA-0184 encodes for the relaxin fusion protein. The mRNA sequence of mRNA-0184 is engineered to increase protein expression and prolong half-life. Moderna is planning for a Phase 1 study in participants with chronic heart failure. The Company expects that mRNA-0184 will be administered after heart failure decompensation to bridge patients through the vulnerable period. Moderna owns worldwide commercial rights to mRNA-0184.
Exploratory Modalities
Cancer Vaccines: These programs focus on stimulating a patient's immune system with antigens derived from tumor-specific mutations to enable the immune system to elicit a more effective anti-tumor response.
Personalized cancer vaccine (PCV) (mRNA-4157): The randomized, placebo-controlled Phase 2 study investigating a 1 mg dose of mRNA-4157 in combination with Merck's pembrolizumab (KEYTRUDA®), compared to pembrolizumab alone, for the adjuvant treatment of high-risk resected melanoma is fully enrolled (n=150). The Company expects the Phase 2 data readout to occur in the fourth quarter of 2022. The primary endpoint of the Phase 2 study is recurrence-free survival at 12 months. The Phase 1 in multiple cohorts is ongoing and the expanded head and neck cohort is recruiting additional patients. Moderna shares worldwide commercial rights to mRNA-4157 with Merck.
- Mutant KRAS vaccine (mRNA-5671 or V941): The Phase 1 open-label, multi-center study to evaluate the safety and tolerability of mRNA-5671 both as a monotherapy and in combination with pembrolizumab, led by Merck, is ongoing. Moderna shares worldwide commercial rights to mRNA-5671 with Merck.
Intratumoral Immuno-Oncology: These programs aim to drive anti-cancer T cell responses by injecting mRNA therapies directly into tumors.
OX40L/IL-23/IL-36γ (Triplet) (mRNA-2752): The Phase 1 trial evaluating mRNA-2752 as a single agent and in combination with durvalumab in patients with advanced solid tumor malignancies and lymphoma is fully enrolled. Enrollment in additional cohorts is ongoing. Moderna owns worldwide commercial rights to mRNA-2752.
Presentation of Note: Moderna will share a poster presentation at the Society for Immunotherapy of Cancer's (SITC) 36th Annual Meeting on November 12.
- Presentation of Note: Moderna will share a poster presentation at the Society for Immunotherapy of Cancer's (SITC) 36th Annual Meeting on November 12.
- IL-12 (MEDI1191): The Phase 1 open-label, multi-center study of intratumoral injections of MEDI1191 alone and in combination with durvalumab in patients with advanced solid tumors, led by AstraZeneca, is ongoing. MEDI1191 is an mRNA encoding for IL-12, a potent immunomodulatory cytokine. Moderna shares worldwide commercial rights to MEDI1191 with AstraZeneca.
Localized Regenerative Therapeutics: Localized production of proteins has the potential to be used as a regenerative medicine for damaged tissues.
VEGF-A (AZD8601): The Phase 2a study of AZD8601 VEGF-A, which is being developed for patients with ischemic heart disease undergoing coronary artery bypass grafting surgery with moderately impaired systolic function, led by AstraZeneca, has completed recruitment after enrollment of the low dose cohort (n=11). Moderna has licensed worldwide commercial rights to AZD8601 to AstraZeneca.
- Presentation of Note: AstraZeneca to present on the VEGF-A program on November 15 at the American Heart Association's Scientific Sessions 2021 annual meeting.
Systemic Intracellular Therapeutics: These programs aim to deliver mRNA into cells within target organs as a therapeutic approach for diseases caused by a missing or defective protein.
Propionic acidemia (PA) (mRNA-3927): The Phase 1/2 Paramount study of mRNA-3927 is ongoing and the first cohort is fully enrolled. mRNA-3927 uses the same LNP formulation as mRNA-1944. Moderna owns worldwide commercial rights to mRNA-3927.
Methylmalonic acidemia (MMA) (mRNA-3705): The Phase 1/2 Landmark study to evaluate the safety and pharmacology of mRNA-3705 in patients 1 year of age and older with MMA is ongoing and the first participant has been dosed. Moderna received rare pediatric designation for mRNA-3705. Moderna owns worldwide commercial rights to mRNA-3705.
- Phenylketonuria (PKU) (mRNA-3283): Individuals with PKU have a deficiency in phenylalanine hydroxylase (PAH) resulting in a reduced or complete inability to metabolize the essential amino acid phenylalanine into tyrosine.
Colleen Hussey
Director, Corporate Communications
Lavina Talukdar
Senior Vice President & Head of Investor Relations
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Nevada woman at center of family abduction case dies
Susan Hillygus, an Alzheimer's patient taken from her Reno care facility in August by her son has died, potentially complicating the criminal case pending against him and an alleged accomplice.
RENO — The elderly Alzheimer's patient whose son took her from a northwest Reno care facility without authorization in August, prompting a weeklong police manhunt, has died, potentially complicating pending criminal proceedings.
Meanwhile, the initial conference on the charges against her son and a second man police named as an accomplice have been pushed into mid-December. The most serious charges against the accused accomplice have been dropped.
Susan Hillygus died Oct. 16, the Washoe County Medical Examiner's office confirmed this week. Taken from her care facility on Aug. 8 by her son, Roger, she was found unharmed a week later at the home of her brother in a Los Angeles suburb, where her son had fled with her.
Her medical condition "would have of course been a challenge, as any case with a victim who may not be able to testify would be," said Michelle Bays of the Washoe County district attorney's office. "Her death is sad for her family and the same type of challenge to a case when a victim is not here to testify."
Roger Hillygus was taken into custody by Los Angeles County sheriff's deputies Aug. 16 after falling asleep seven hours into a stand-off with police in the Bellflower apartment complex where he holed up with his mother for nearly a week. He faces charges of second-degree kidnapping, conspiracy to commit kidnapping and burglary.
Veteran cop charged
Those same charges were initially leveled at one of two men who went with Hillygus to see his 80-year-old mother at the Stone Valley Alzheimer's Special Care Center on Aug. 8. Hillygus, formerly his mother's guardian, had been stripped of that role in a long-running family guardianship dispute and was not authorized to leave the facility with her.
Reno police's decision to charge Stewart Handte, a veteran Nevada law-enforcement officer, as an accomplice drew national attention to the case. Handte is a former Mineral County sheriff who during a 30-year career in law enforcement also served in the state Highway Patrol, as a Storey County deputy, and as chief of two tribal police forces.
Handte was arrested despite telling police he was unaware of Hillygus's plans to abscond with his mother. Hillygus had earlier displayed a document purporting to be a jury verdict that restored him as guardian. They had left the facility unchallenged by staff there.
Hillygus had filed so many frivolous and defamatory motions in the guardianship dispute that opposing lawyers had sought to have him declared a "vexatious" litigant, and he was removed as guardian in 2015 after repeatedly failing to heed court orders.
Handte was taken forcefully into custody by a half-dozen officers in tactical gear the day before Hillygus and his mother were found. Despite being charged with serious felonies, he was released without having to post bail. The top charges against have been dropped, and he now faces only a conspiracy charge.
'Rush to judgment'
Prior to his arrest, Handte had been in communication with a reporter on a daily basis regarding the events surrounding the abduction and, later, his arrest.
The cases against the two are scheduled for conference a week before Christmas. Joey Gilbert, Handte's attorney, declined to discuss specifics but said available evidence, along with his own investigator's review of events, pointed to a "rush to judgment" against Handte.
"I don't see where Mr. Handte committed a crime or anything that rises to the degree of what he's been charged with," Gilbert said.
Contact Bill Dentzer at email@example.com or 775-461-0661. Follow @DentzerNews on Twitter.


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