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here you'll find answers to the most frequently asked questions.
Want to know more about what makes Cipher, well, cipher? check us out.
Properly preparing skin for your skincare routine is important. without cleansing, a barrier of built up oils, dirt, and environmental pollutants sit between your products and your skin. Here are our cleansing tips to help your skincare do the most work for you.
Start with these suggestions, but always stick with a method that makes your skin happy.
Goal: remove all makeup, SPF, dirt, And other residues from the surface of skin without disrupting its natural balance.
First, If you're wearing makeup or sunscreen, remove it. We recommend this pre-cleansing step every evening, makeup or not, to avoid leaving residues from the day behind. Use an oil-based balm cleanser and/or micellar water to dissolve the makeup and rinse it away easily without tugging on the skin. our cloud melt hybrid cleanser is a perfect pre-cleanse or first-cleanse option!
Apply your cleansing balm or oil cleanser of choice to dry skin to maximise it's impurity dissolving powers. Massage for 30 seconds before adding a touch of water to emulsify and lift the residues from your skin. Rinse thoroughly with warm water or remove with a damp facial cloth.
Next, Your staple cleanser should be gentle and ideally have a pH near 5.5—like our beloved CLoud Melt. Most prefer a cream or foaming gel version for this step, but choose one that suits you. Massage your cleanser into skin for at least 30 seconds to properly dissolve impurities and deep clean pores, focusing on any congested areas. Rinse clean, taking extra care along the hairline.
more cleansing tips:
- Avoid overly abrasive physical exfoliants (walnut shells, we're looking at you) and harsh surfactants, like the infamous SLS, that can strip the skin of its natural oils.
- If your skin is feeling tight after cleansing, you likely would do better with a gentler option. Think fewer/milder surfactants, balanced pH, less scrubbing, and skin-nourishing ingredients (ahem, Cloud Melt!).
- if you're looking to add some physical exfoliation, stick to gentle scrubs or consider removing your cleanser with a muslin or microfiber cloth. Exfoliating too often or too aggressively can cause skin to become reactive, so proceed with caution and pay attention to how your skin responds!
Goal: hydrate, ensure proper pH balance of skin, and potentially add light physical exfoliation.
Toner is optional, but can be a great addition to your routine. Choose a toner that suits your skin's needs. This is a great opportunity to boost AHAs for chemical exfoliation or add nourishing, calming agents to soothe stressed skin. avoid products with denatured alcohol. water is your skin's best friend, and Applying a watery toner will allow your skin to drink it up quickly and provide more hydration for your serum/moisturiser to lock into place.
certain toners or hydrating mists may be spritzed on after cleansing or any time of day to add moisture and refresh. If you'd like a touch of physical exfoliation, consider using a reusable cotton round to apply your toner. Gently sweep over your entire face, focusing on problem areas like the nose.
toning/cleansing tips:
you're using a pH balanced cleanser (good job!), but have you considered the pH of your tap water? Tap water can often have a pH of around 8. A pH this high can disrupt our skin's natural pH of 5.5, and a toner can help bring it back into balance.
Now you're ready to get the most out of your cipher products!
Do I really need sunscreen every day? Even in winter? When it's raining? When I'm inside all day?
Sunscreen is your first line of defence against damaging UVA (mostly aging) and UVB (mostly burning) rays. Physical (mineral) and chemical (organic) Sunscreen work mainly by absorbing UV rays and converting them to a safe level of heat before they impact your skin.
UVA rays can penetrate windows and clouds, so even when you're sitting in that office, in your car, on a plane—wear sunscreen!
Still not convinced? Consider this: UV rays are the single biggest cause of premature aging. If you're investing in skincare and diligently following a routine, Don't risk undoing your hard work. Wear sunscreen!
The best sunscreen for you is one you're happy to use every day.
How do I find the one?
There are many, many options that can meet your sun protection needs. Experiment to find a consistency and formula that works best with your skin, and Shoot for spf 30 or greater.
Cancer Council Australia states one full teaspoon is needed to effectively cover face, neck and ears—so don't short yourself! Less is NOT more when it comes to SPF. Remember to apply 20 minutes prior to sun exposure and ideally reapply every 2 hours.
As an aside, It's not recommended to rely on the SPF in your makeup alone. You'd have to apply an excessive amount (remember: one tsp!) to attain the SPF rating stated on the packaging.
Sunscreen options to Consider.
- a mineral-based option. Your answer if you want to keep it natural. These can sometimes feel a bit weighty on the skin and leave a slight white cast, but There are exceptions!
- an "invisible" sunscreen. These are usually silicone-based chemical sunscreens. They live up to their name if you're not fond of the typical heavy sunscreen feel. Also great for deeper skin tones.
- a tinted or clear moisturiser with SPF. There are some beautiful hybrid formulas becoming available. If you go the tinted route, ensure you're applying enough for proper SPF protection!
reapplication ideas.
- setting spray with spf. probably your quickest option for a top up.
- translucent finishing powder with spf. a great mattifying booster if your skin tends to be on the oily side.
- want to reapply your regular sunscreen? try using a dense makeup sponge with a tapping technique to press into skin with minimal impact to makeup. check out hannah (@ms_hannah_e), australia's resident spf beauty guru, for some great tips.
Looking for brand suggestions?
A few of our favourites are Ultra Violette (Australia) and Supergoop! (USA), but there are many more great brands to explore.
we use natural preservatives accepted by ecocert as ingredients in certified organic cosmetics. In addition, they are on the whole foods acceptable premium preservative list.
INCI: Leuconostoc/Radish Root Ferment Filtrate
derived from radishes fermented with Leuconostoc kimchii; a lactic acid bacteria that has traditionally been used to make kimchi. Its antimicrobial benefits not only keep the products healthy and safe, but may also benefit acne prone skin.
INCI: Lactobacillus (and) Cocos Nucifera (Coconut) Fruit Extract
developed by fermenting Coconut fruit with Lactobacillus, it prevents the growth of fungus, especially yeast and mold. It's non-irritating, effective and multifunctional; providing moisturising and conditioning benefits to boost skin health.
We ship worldwide! Free shipping options are always available.
Shoot us a message on our contact form or leave us a comment on a recent Instagram post and we'll try our best to help.


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One small paper mache lizard ready for you to paint and decorate. It measures about 6" long . Paint or decoupage her for a great accent piece.
12" Paper mache 3-dimensional star
Regular price
2.5" Paper mache ball ornaments, set of 6
Regular price
3 Christmas tree gift boxes Paper mache
3 Paper mache cones, 7"x3" contemporary Christmas tree
Regular price

subset: commoncrawl


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Heart Tote Bag
Beautiful hand designed (freehand) Heart Canvas Tote Bag.
This was Meghan's first 'Valentine' design. There is a hidden message of 'you're lovely' within the design. This design can also be seen engraved onto Wooden and Acrylic hanging hearts (see shop).
The bags are then printed using a local printer.
These are a perfect gift for wedding or baby shower favours.
The bags are also machine washable at 30 degrees.
Please contact Meghan if you would like to order 20 or more, if you would like the bag in a different colour, or if you would like a name printed on the bag.


text: Manufacturer All Manufacturers Model All Models Type All Types Price Range All Price Ranges Fuel Type Any Fuel Search... (e.g. RWD) Fuel Type Any Fuel Transmission Any Transmission Economy Any Economy Power Any Power Doors Any Doors Emissions Any Emissions Price Match Promise Easy Online Ordering Dedicated Account Manager Online Vehicle Portal Fast, FREE Delivery Highly Rated Service HomeCarsSmartFORTWOFortwo 2 Door Coupe EQ 22KW Pulse Premium Auto Smart FORTWO Fortwo 2 Door Coupe EQ 22KW Pulse Premium Auto * images are for illustration purposes only, all vehicles are brand new and right-hand drive. From £185.60 Per MonthExc. VAT £185.60 Per Month Exc. VAT Initial Rental: £1,670.40 | Product Type: Contract Hire Customise Your Lease BUSINESS PERSONAL INITIAL RENTAL (months) 3 6 9 12 CONTRACT LENGTH (months) 24 36 48 60 ANNUAL MILEAGE - 5,000 miles * Selection in ORANGE represents the best deal price. Price based on the following terms: Product Type: Business Contract Hire Initial Rental: £1,670.40 Contract Length: 48 Months Annual Mileage: 5000 Miles ( if you require different terms please enquire ) * excess mileage charges will apply for mileage usage in excess of the total contractual mileage* end of contract damage charges may apply VEHICLE MAINTENANCE Would you like to add vehicle maintenance to your package for only £17.83 per month? [ Find out more about Maintenance here ] YES Please add vehicle maintenance to my package NO Do not add vehicle maintenance to my package COLOUR / TRIM Black / Black Fabric+White Double Stitching White / Black Fabric+White Double Stitching Carmine Red / Black Fabric+White Double Stitching Cool Silver / Black Fabric+White Double Stitching Gold Beige / Black Fabric+White Double Stitching Midnight Blue / Black Fabric+White Double Stitching Matt Paint-Titania Grey / Black Fabric+White Double Stitching KEY FEATURES AS STANDARD Bluetooth/Phone Connectivity Air Conditioning Parking Sensors Electric Mirrors RANGE 4.9 M/KWh BATTERY VOLTAGE 350 V TOP SPEED 81 mph BATTERY CAPACITY 17.2 KWh FUEL TYPE Electric FEATURES SPECIFICATION UPGRADES & EXTRAS FEATURES Audio and CommunicationsBluetooth Connection-Audio Streaming/TelDigital Radio Smart Media System 9in Mlti Touch DisplyExterior FeaturesCentral Locking Wth Radio Remote ControlElectric Adjust/Heated Exterior Mirrors Panoramic RoofRear Parking Assistance Sensors Rear View Camera Third Brake Light LED TechnologyWind Deflector Interior FeaturesAutomatic Climate Control Cruise Cntrl+Spdtronic Variable Spd LmtrElectric Windows Height Adjustable Drivers Seat Height Adjustable Steering Wheel Outside Temperature Display Mechanical FeaturesAutomatic Start/Stop Function Electric Power Steering ESP Other3 Years/Unlimited Mileage Paint and TrimBlack Fabric+White Double StitchingBodypanels In Solid Safety & Security FeaturesABS + EBD + Brake Assist Active Brake AssistCrash Sensor For Actvtn Hazard Warning Crosswind Assist Driver Knee Airbag Drivers Airbag Front Side + Pelvis/Thorax Airbags Front Side Airbags-Combined Head/Thorax Immobiliser Passenger Airbag Window Airbag Wheels16in 5TwinSpoke Design Light Alloys-Blck SPECIFICATION Engine and Drive TrainTransmission TypeAutomaticEngine Size0 ccEngine ConfigurationElectric MotorFuel TypeElectricFuel Delivery TypeBatteryBatteryRange4.9 M/KWhBattery Voltage350 VBattery Capacity17.2 KWhEmissionsCO20.0 g/kmEuro Emissions StandardEURO 6 Fuel ConsumptionWLTP - Electric Consumption Combined17 kWh/62 milesWLTP - Electric Consumption Combined Minimum14 kWh/62 milesWLTP - Electric Consumption Combined Maximum15 kWh/62 milesWLTP - All Electric Range Combined108 milesWLTP - Electric Range Combined75 milesPerformanceMaximum Speed81 mph0 to 62 mph11.6 sPower (BHP)80.0Power (PS)81.1Power (KW)55.9Torque118.0 Lb/ft @ 1800 rpmDimensions and WeightsLength2695 mmWidth1893 mmHeight1555 mmWheelbase1873 mmBoot Capacity9.20 cubic feetGross Weight1310 kgKerb Weight1095 kgGeneralBody StyleCoupe/TargaDoors2Seats2Insurance Group17RFL Rate£0.00Front BrakesDISCRear BrakesDRUMStandard Front Tyre Size185/50R16 VStandard Rear Tyre Size205/45R16 VStandard Spare Tyre SizePuncture repair kitService IntervalsFirst Service0 months / 0 milesInitial Service12 months / 12500 milesSubsequent Service12 months / 12500 milesWarrantiesBody / Anticorrosion72 months / 0 milesMechanical24 months / 0 milesRecovery / Breakdown24 months / 0 miles UPGRADES & EXTRAS Download Vehicle Specification EMAIL ADDRESS I wish to receive emails from CVC for updates on the latest lease deals, offers and promotions. View our Privacy Policy for more information Important Information All of our vehicles are supplied brand new and directly from manufacturers franchised dealer network, your vehicle will be supplied with a full manufacturers warranty and will be delivered anywhere in the UK for free. Information and prices are correct at the time of publishing which is subject to change, our leasing offers are subject to availability, can change and may be withdrawn at any time without prior notice. All vehicles images and descriptions are for illustration and reference purposes only. Excess mileage charges will apply for mileage usage in excess of the total contractual mileage. End of contract damage charges may apply. Visit our terms and conditions for more information on leasing a vehicle through Commercial Vehicle Contracts Limited. Customers Also Viewed Peugeot 108 108 3 Door Hatch 1.0 72 Allure S+S Contract Hire Price Per Month, Exc. VAT From £147.77 Initial Rental £1329.93 Exc. VAT Citroen C1 C1 3 Door 1.0 VTi 72 Touch Contract Hire Price Per Month, Exc. VAT From £132.08 Initial Rental £1188.72 Exc. VAT Peugeot 108 108 5 Door Hatch 1.0 72 Active S+S Contract Hire Price Per Month, Exc. VAT From £136.67 Initial Rental £1230.03 Exc. VAT Peugeot 108 108 3 Door Hatch 1.0 72 Active S+S Contract Hire Price Per Month, Exc. VAT From £134.47 Initial Rental £1210.23 Exc. VAT Citroen C1 C1 Airscape 5 Door 1.0 VTi 72 Flair Contract Hire Price Per Month, Exc. VAT From £141.30 Initial Rental £1271.70 Exc. VAT Make an Enquiry Smart FORTWO Fortwo 2 Door Coupe EQ 22KW Pulse Premium Auto From £185.60 Contract Hire Price Per Month Exc. VAT Colour & Trim: Black / Black Fabric+White Double Stitching Initial Payment: £1,670.40 Initial Rental: 9 Months Contract Length: 48 Months Annual Mileage: 5000 Miles Maintenance Included: No * images are for illustration purposes only, all vehicles are brand new and right-hand drive. Make sure you fill in the form with the correct details so that your quote can be emailed to you successfully Dealt with someone at CVC before, please state name I agree that CVC may process my information in accordance with their terms & conditions and website privacy policy. Sign up to our van leasing and car leasing mailing list SUBMIT REQUEST


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Paper makes up 27 percent of municipal solid waste, which is more than any other individual material Americans throw away. For this reason, the need to recycle paper is extremely important to reduce the amount of waste placed in landfills. In 2012 Americans recycled about 65 percent of the paper they used Recycling paper saves … Continue reading Paper
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Specialty Pharmacy Certification Board, President
Brandon Newman is a graduate of the University of Tennessee, holding Bachelor of Science and Doctor of Pharmacy degrees. Brandon received his Master of Management in Health Care from the Owen Graduate School of Business at Vanderbilt University. With more than 12 years of Specialty Pharmacy experience, across adult and pediatric enterprises, Brandon has served in various clinical and leadership roles at Accredo, Medco, Express Scripts and Vanderbilt Specialty Pharmacies. Currently Brandon is the Vice President of Clinical Affairs for Trellis Rx where he partners with Health Systems to improve outcomes for their specialty patients.


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Is Ant Man the film to ruin Marvel's winning streak? No. Is it as good as Honey, I Shrunk The Kids?
Hell no.
And don't you come around these parts no more asking such questions…
It barely feels as if the dust has settled after Avengers: Age of Ultron, but Marvel Studios are back with Ant Man, their second release of the year and twelfth movie in their ongoing sprawling 'cinematic universe'. Back in April, I described Age of Ultron was one big victory lap for Marvel, a gigantic superhero smackdown with the heroes bringing the sarc and James Spader bringing the snark. In many ways Ant Man feels like something of an antidote.
Obviously, if you were looking for the 'no more superhero movies' kind of antidote, it's not that…
Based on the comic series founded by Stan Lee back in the Sixties. Ant Man begins with Scott Lang (Paul Rudd) leaving prison in an attempt to rebuild his life and reconnect with his daughter. Life however proves to be tough on the outside, and Scott finds himself returning to his life of petty crime in an attempt to make ends meet and pay off his parental fees, just so he can see his daughter.
When one job leads him into stealing a strange suit that allows the wearer to miraculously shrink themselves down to tiny sizes at will, he comes into contact with the suit's original creator Hank Pym (Michael Douglas). Pym has spent his life hiding his research and preventing it from getting into the wrong hands. Unfortunately his scorned protege Darren Cross (Corey Stoll) has found a way to weaponise his technology in the form of a similar suit named the yellow jacket which he plans to sell on to the highest most unscrupulous bidder imaginable. With the help of Pym and his daughter, Hope (Evangeline Lily), Scott is trained up to take the mantle of Ant Man and is tasked with breaking into a secure installation to destroy what remains of the technology.
Ant Man is a heist movie but it is also a remake of the first Iron Man movie which kicked off the Marvel cinematic universe in the first place back in 2008. You have a charismatic, perfectly flawed white male looking to master a suit that grants him super powers in an attempt to make the world a better place. In doing so, he must learn to find his inner peace. In place of a bald Jeff Bridges, you have another bald bad guy looking to make profit by selling pieces of the hero's advanced technology to nefarious organisations.
The film has been in development for a long time, perhaps longer than the age of the Marvel cinematic universe. Edgar Wright was originally in line to direct the picture, as a jokey sendup of the superhero genre. He is still credited for writing the screenplay, along with Joe Cornish (Attack the Block), and at time you can feel their quirkier touches imprinted in the humour. Though it would have been fantastic to see Edgar Wright's take on the character, director Peyton Reed serves up a well rounded movie, with great humour and some of the most imaginative action scenes yet seen in a Marvel movie. Ant Man is kept small and light, and in many ways I preferred it to the dizzying spectacle of Age of Ultron.
Ultimately the main difference comes in scope. Ant Man is about a man who can shrink himself and talk to ants, and like it's hero it takes confidence in not being that movie where the stakes are so stupendously high. Oh sure, there are large amounts of special effects wizardry, but the scale of the movie feels smaller and more personal. There are no massive sky battles or elaborate domesday plots spawned from cosmic macguffin gems. The final fight feels as if Marvel is poking fun at their own shtick, a massive epic battle playing out on a much smaller scale, namely a toy Thomas the tank engine railway set.
As Scott Lang, Paul Rudd is essentially playing Paul Rudd in every Paul Rudd movie that's ever been made. He's a likeable presence that carries the whole however, and at the very least you root for the character simply because he is someone who is trying to do better in his life and become the hero his daughter thinks he is. On top of the Edgar Wright DNA, Paul Rudd and Adam Mckay were also involved in the writing process to fit it more into… well… a Paul Rudd movie. Luckily there is no sign of Will Ferrell.
It's also great to see Michael Douglas on the big screen again. There is a brief flashback sequence at the start of the movie that has a younger Gekko looking Douglas laying the verbal and physical smackdown on a panel of recognisable SHIELD execs. As Hank Pym, Douglas is the cantankerous mentor and the overprotective father. Pym's arc is neatly mirrored by Scott's, in that he is essentially looking to reconnect with his daughter. Douglas obviously brings the mentorly charm to the role, but in one of the more dramatic scenes, you are reminded of what a great actor he is.
Evangeline Lily's character occupies the strange position as the hard chick, clearly the person best suited to donning the suit in the first place. Obviously she's relegated to the side for the duration of the movie to support her father as he trains up the hapless thief. The movie gives a perfectly good reason for this, though Pym is desperate he is unwilling to sacrifice his daughter even in the pursuit of the greater good, which in some ways gives the character more believability and humanity. On the other hand, a mid credits sting feels as if Marvel are directly addressing the lack of women in their superhero roles. There have been twelve of these movies. About time indeed.
Less effective is Corey Stoll as the bad guy Yellow Jacket. It's been a good year for uninspired but gleefully scenery chewing villains. Vincent D'onofrio hammed it up in Jurassic World and Hugh Jackman's bohan bad guy in Chappie was probably the best thing about the movie. We now have Yellow Jacket to add to this list.
Having graduated from the world of critically acclaimed TV (House of Cards) Stoll's character is basically an evil version of Ant Man with added lasers (that sound remarkably like the laser weapons of an AT AT from Star Wars… is that relevant?). He is led to evil because his former mentor and father figure Pym never truly appreciated his genius. It has kicked the process of bastardisation into overdrive of course, resulting in a character who reduces people and innocent little lambs into small pools of bloody pulp. At one point it is pointed out how the molecular chemical that allows him to use the Yellow Jacket size warping technology is 'making' him more evil. Which I had to kick myself for, as it's just about the laziest excuse you could have to explain somebody's fall into villainly. It was the evil juice that affected my brain. Granted the smallest chemical imbalance to the brain can have a catastrophic effect on human behaviour, but come on…
In the end, Yellow jacket is just another of Marvel's undercooked villains. Marvel take so much time and effort getting the hero right, the villain has a habit of feeling peripheral as a mere obstacle or boss stage, the heroes must get past in the third act so they can go on to the sequel.
Undoubtedly, the highlight of the movie is Michael Pena as Scott's hispanic criminal buddy, Luis. He injects the film with warmth and comedy and steals pretty much every scene he appears in. I'm been used to seeing Pena in gritty movies like End of Watch or Fury, but as the comedic sidekick in Ant Man he is a revelation. A recurring gag has him explaining the story of how he gained a tip in unscrupulous detail. The 'backup scene' is also one of the funniest bits in the movie.
Marvel already made a success out of the movie starring a talking gun toting raccoon and his tree man sidekick, and their streak in making crowd pleasing action adventures doesn't stop with Ant Man. Though there are nods to the larger Marvel cinematic universe, with Paul Rudd destined to take his place in that glorified long shot alongside the rest of the Avengers, the new Avengers, the Guardians of the Galaxy, and Benedict Cumberbatch, Ant Man at this stage feels refreshingly as it's own movie.
For the most part Ant Man excels in being that smaller film with a tighter focus. It's never too preachy with the superhero spiel and is genuinely funny the whole way through. The big/small action scenes are well constructed and have an element of imagination over superhumans punching each other. In many ways I preferred it to the flabbier indulgence of Age of Ultron. There are stakes, but they don't involve mass genocide, there is enough heart to anchor all the quips, finally, it may just make you appreciate ants in a different light.
Related Movies About Shrinking:
Honey, I shrunk the kids (1989)
Better than Ant Man. Shrinks Ant Man down to size and then eats him with cheerios.
Innerspace (1987)
Just waiting for the remake. In which James Franco is shrunken down to pilot a microscopic vessel around Seth Rogen's body. Cue weed jokes and homo-erotic lines of men being inside one another. Ha ha ha ha. What is up with that? I literally cannot wait…*


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Old-town lodging on four floors (there's a lift), with small but comfortable en-suite rooms, full of character, with air-conditioning, wi-fi and TVs. The abundant breakfasts are usually served in a separate building nearby. Pietro, the owner/manager, is happy to dispense local advice.
Right on the main street, the three rooms here are located around a courtyard, each with its own entrance. They don't have views but are cool, spacious and quiet, with modern bathrooms, fridges and air-conditioning. Breakfast is available at a bar across the road. Emanuele, the friendly and helpful owner, offers arriving guests an aperitivo of local Malvasia.
Traditional house in a quiet nook of the old town, tastefully converted with all the modern amenities. The spacious rooms have character and style, and all have air-conditioning, satellite TV and small but modern en-suite bathrooms. The owner, Cinzia, is friendly and helpful.
On the river bank, this finely renovated old palazzo has spacious and functional rooms, beautifully decorated, and some with views. If rooms aren't available in the main building, you may be staying in one of the equally comfortable annexes. Wi-fi and bikes are available.
This three-star hotel in the heart of the old town has most of its rooms in a beautifully restored nineteenth-century palazzo, while others are located in a town-house dug out of the rock nearby, with inspiring views. All rooms have modern fixtures and facilities, fridges and wi-fi. Breakfast is taken in the Taverna bar across the road. Vanna, the manager and co-owner, is an expert on the local wine scene (aghinas = grapes in the Sard language).
Two grand, aristocratic-style apartments are right on Bosa's main square, with a bird's-eye view of the comings and goings. The large, bright rooms are tastefully furnished and have a/c. Everything is provided—towels, sheets, kitchen items—and one of the two has a terrace balcony. Both are on the third floor of the building, however, so not suitable for anyone averse to climbing stairs.
In the warren of lanes that make up Bosa's Sa Costa quarter, this tall narrow house has got plenty of atmosphere. It's been beautifully modernised inside, with surprisingly airy rooms, and there's a small terrace. Sheets and towels are provided.
This modern villetta is in the new part of town, just over the river from the old quarter. It's on two floors and has a small terrace. There are two bedrooms upstairs, both with balconies, and a lounge with French windows below. All towels, sheets and kitchen items are there—and there's a TV.


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Rapoport Lab clarifies mechanism of Cdc48 ATPase - Apr 21, 2017
The ubiquitin-proteasome system is responsible for regulated destruction of a wide variety of proteins in eukaryotic cells. Some targets, such as proteins embedded in membranes or stable macromolecular complexes, require prior processing by an ATPase known as Cdc48 in yeast, or p97 in higher organisms. The function of Cdc48/p97 and its cofactors Ufd1 and Npl4 (UN complex) is best understood in the case of endoplasmic reticulum-associated degradation (ERAD), in which Cdc48 extracts proteins from the ER membrane before they are degraded in the cytoplasm. Cdc48/p97 consists of an N-terminal domain that binds UN and two stacked hexameric ATPase rings (D1 and D2) surrounding a central pore. How exactly Cdc48/p97 processes its substrates has been unknown.
In a recent paper in Cell, Bodnar and Rapoport analyze the mechanism of Cdc48/p97. In vitro reconstitution of Cdc48 function with purified yeast components shows that the ATPase cooperates with UN to unfold its polyubiquitinated targets by passing them through its central pore. Translocation requires ATP hydrolysis in the D2 ring, whereas ATP hydrolysis in the D1 ring is required for substrate release from the ATPase complex. Substrate release also requires deubiquitination. Surprisingly, the ubiquitin chain is not completely removed; rather, the remaining oligoubiquitin chain is also translocated through the pore. These results lead to a new paradigm for Cdc48 function in diverse cellular systems.


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For Sale: Lightly Used HDS XPG 200 Lumens, 6200K, Rotary with Raised Tail Switch. This light has a beautiful white beam, solid rotary action, three-click to lockout function, no marks or scratches on the light. This light throws well and is somewhat cooler than sunlight at noon.
Price: $210 SOLD Shipped USA, first "I'll take it" followed by a PM for PayPal information gets this beautiful HDS Rotary.


text: ICRC "This guide is intended to help health-care personnel adapt their working methods to the exigencies of armed conflicts and other emergencies. The provision of health care in these circumstances can give rise to many unforeseeable dilemmas. The guide cannot provide answers to such dilemmas; it should, however, provoke reflection, ease the making of decisions, fuel discussion and, ideally, provide guidance for practice in the most difficult circumstances." (pdf)


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01609 591080
email@example.com 01748 824246
Vintage, retro, collectables, jewellery gifts, sweets & cards PLUS a pop up tearoom provided by The Tea Set - there really is something for everyone!
Doors open at 10 until 4pm and admission remains free. There is a fantastic selection of traders and some new faces! Click the logo for more information


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Project Music is strategically located in Nashville, Tennessee, a city that has already established its credibility as a music industry hub. After all, it is called Music City. The city has a deep history of innovation around music, having planted the seeds for the music ...
One day, multi-platinum recording artist MIMS had an idea. He had to share it with his manager, Erik Mendelson. "I'm a gadget freak, from early on. I want to be creative in this way, too," says MIMS. "I come up with all these crazy ideas, and sometimes he perks up. I had an idea for an app that would allow consumers to create their own original song with their favorite producers. "
The idea gradually evolved into RecordGram, an app that connects award-winning and up-and-coming producers with aspiring vocalists and artists. With one tap, users can lease beats for a very small fee, record audio and video, keep track of their lyrics, monitor their vocal performance, and share their creations in app with other RecordGram users and across all other social networks. Producers upload full instrumentals to the app for users to play with, and get a share of the income from this in-app use of their tracks.
"We wanted to create a way aspiring artists around the world can collaborate with producers, with a touch of the button," explains Mendelson. "We wanted to make the collaboration and creative process simple, convenient, and affordable, while creating new revenue streams for producers."
The idea continued to evolve as the team, which includes Grammy-winning DJ Blackout, participated in Project Music, the first technology business accelerator dedicated to the future of the fast-changing music industry. Along with six other music tech startups and a not-for-profit ensemble, the RecordGram team honed their business-building skills, developed influential contacts, and attracted impressive investments. Now in its second year, the Project Music Accelerator is a partnership between the Nashville Entrepreneur Center (EC) and the Country Music Association (CMA).
RecordGram's founders had a lot more than intriguing, crazy ideas going for them. A lifelong music obsessive, Mendelson had decades of experience in the music business, thanks to stints in radio promo for Elektra and Jive/Sony, where he helped break Chris Brown and T-Pain, as well as extensive success in management and marketing. One of his management coups: Helping MIMS score a major label deal. MIMS has several hits and successful albums under his belt, as well as a penchant for brainstorms that feed his passion for tech.
This didn't make the road to developing and launching RecordGram an easy one. Because of the app's model and new form of licensing, "Lots of doors were not opening. This was a new thing. We're used to having the doors open in the music business," muses MIMS. "As we dealt with the bumps in the road, I kept coming up with new ideas. We decided to forget about licensing content, and to create new content. We decided to empower aspiring songwriters, so they can create their own music."
They can also share their creations on The Stage, RecordGram's social community, as well as on Facebook, Twitter, and Instagram. "RecordGram fills a void for creators, for people who are just starting out or are very passionate amateurs," says Mendelson. "At the same time, we're not just making a cool platform for amateur artists, we were creating a platform for producers."
Producers have struggled to find new income sources to make up for falling sales in the digital music era. The RecordGram crew wanted to address that need by making a platform where producers could register and effectively lease their beats, lending them to creators for limited use--but giving them powerful inspiration to make and share music.
"We have brought it all together in a single app. We are a fully integrated mobile production store for beats. We're an audio and video recording studio, and we also have a social network," Mendelson notes. "We're geared toward the amateur kids who just want to have fun with music. If you can't afford a producer's fee or studio time, you can still make really cool tracks."
Visit http://www.recordgram.com for more info and download the app here.
About the Nashville Entrepreneur Center (EC):
The EC, with offices at 41 Peabody Street in the Rutledge Hill area, was founded as a not-for-profit 501(c)3 economic development initiative of the Nashville business community with a vision to become the best place in America for entrepreneurship. Its mission is to connect entrepreneurs with critical resources to create, launch, and grow businesses. For more information, visit http://www.ec.co/.
About Project Music, An EC Initiative:
Project Music is the Nashville Entrepreneur Center's leading action to support innovation within the music industry, a core business vertical in Nashville's economy. To meet the unique needs of music-minded entrepreneurs building music-centric business, the EC is providing a year-round music entrepreneurship focus that brings music, tech and business leaders together to nurture startups desiring to grow music industry revenue. The program's capstone is the annual four-month-long Accelerator. For more information, visit http://www.projectmusic.co/.
About the Country Music Association (CMA):
Founded in 1958, the CMA was the first trade organization formed to promote a type of music. In 1961, CMA created the Country Music Hall of Fame to recognize artists and industry professionals with Country Music's highest honor. More than 7,300 music industry professionals and companies from around the globe are members of CMA. The organization's objectives are to serve as an educational and professional resource for the industry and advance the growth of Country Music around the world. This is accomplished through CMA's core initiatives: the CMA Awards, which celebrates its 50thAnniversary this year of recognizing outstanding achievement in the industry; the CMA Music Festival, which benefits music education and is taped for a three-hour TV special; and "CMA Country Christmas," featuring Country artists performing original music and Christmas classics. All of CMA's television properties will air on the ABC Television network through 2021. For more information, visit http://www.cmaworld.com/


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The court order states that my ex-wife is "…entitled to a 50% share of the employee's benefit based on the service…February 25, 1990 through December 6, 1996." Suppose I retire in 2020 with 30 years of service. Since we were married for 7 years, i think her share will be (7/30)X50%=11.665 %.
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Did you receive a notification OPM had determined the Court Order Acceptable for Processing (COAP)? According to the OPM Benefits Branch they send both spouses a letter with the calculated % but neither of us received a letter: divorced 2003
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The cAMP (adenosine 3′,5′-monophosphate)–activated guanine nucleotide exchange factor (GEF) Epac2 is an important mediator of cAMP-dependent processes in multiple cell types. We used real-time confocal and total internal reflection fluorescence microscopy to examine the spatiotemporal regulation of Epac2, which is a GEF for the guanosine triphosphatase (GTPase) Rap. We demonstrated that increases in the concentration of cAMP triggered the translocation of Epac2 from the cytoplasm to the plasma membrane in insulin-secreting β cells. Glucose-induced oscillations of the submembrane concentration of cAMP were associated with cyclic translocation of Epac2, and this translocation could be amplified by increases in the cytoplasmic Ca2+ concentration. Analyses of Epac2 mutants identified the high-affinity cAMP-binding and the Ras association domains as crucial for the translocation. Expression of a dominant-negative Ras mutant reduced Epac2 translocation, and Ca2+-dependent oscillations in Ras activity synchronized with Epac2 translocation in single β cells. The cyclic translocation of Epac2 was accompanied by oscillations of Rap GTPase activity at the plasma membrane, and expression of an inactive Rap1B mutant decreased insulin secretion. Thus, Epac2 localization is dynamically controlled by cAMP as well as by Ca2+-mediated activation of Ras. These results help to explain how oscillating signals can produce pulses of insulin release from pancreatic β cells.


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A few days ago we shared the first article in a short series about the challenges and considerations when building larger multi-rotors for taking video or photos. In case you missed it, you can read it here. I had the opportunity to spend a few days with Ben Wilkinson of 3DXR, who is of the experts on this subject whom I met at a commercial pilots training course. Ben is one of the owners of the business, a professional pilot and reseller of the equipment needed to build such a model.
I asked Ben how they go about picking the components and building the multirotors for customers. 'There isn't an off the shelf solution if you want something bigger than a DJI Phantom but less than the huge models that weigh over 7kg' he explained, 'if you can build a model that weighs less than 7Kg, including the batteries, then the permission and process needed to fly commercially are a little easier.'
Last time we looked at what you needed to consider when building a large multirotor for video or camera work. This time we continue to pick the brains of Ben from 3DXR on the other elements that need consideration.
The Flight Controller
There is a lot of choice for the flight controller for a larger model too. Rarely will you find a larger model not running a flight controller without advanced GPS ability. The extra weight and expense means that these larger models need to be treated with a even more care.
There are a few popular choices for pilots building their own large multirotor model. All of the flight controllers we will look at below offer smooth flying, great redundancy, mission planning, and autonomous flight as well as key features like Geo-fencing (where you can set limits to the range and height of the model that stop it from accidentally flinging too far or high). Making sure that you pick a system with excellent failsafe detection and handling. Making sure that the model will handle a problem safely is key when looking at building a larger model. All of the choices below have some form of GPS 'return to home' feature that will try and fly the model back to the launch point in the event of a problem and handle issues with radio connection problems, power issues, and low battery.
The PixHawk is a very common choice for pilots with larger models. I've looked at this a few months ago in an article but the latest version of the PixHawk, called the 2.1 or 'Cube', is the latest generation of the technology. The PixHawk supports multi-rotors, planes, cars, boats and even submarines.
To sum up the detail in that article – the latest PixHawk called the PixHawk 2.1 also called the 'Cube' is the most fault tolerant advanced PixHawk yet. It has three of most and at least one of each the key sensors (excluding the GPS), you can use redundant power systems and the main sensor IMU array along with the main flight controller is enclosed in a temperature managed sealed unit mounted on shock absorbers.
The PixHawk has fantastic GPS modes, a huge community and very active development of the supporting software. Applications like Mission Planner, APM: Planner and QGroundControl are easy to use and with the PixHawk they make for easy setup and super smooth flight.
Be careful using come of the clone PixHawk flight controllers, not all of them have had the same attention to detail and testing.
Flight controllers like the N3 and others from DJI are good choices too. They are designed for these applications, support all of the DJI technology and have great GPS and failsafe as well.
The N3 has dual IMU, improved algorithms for stability and reducing magnetic interference and links easily with other DJI products like their gimbals, intelligent speed controllers, Lightbridge 2 and DJI Smart LIPO Batteries.
Primarily designed around multi rotors they offer a wide range of supported frame types, a 16 point ground station for iPad and PC (with the optional 2.4Ghz Bluetooth datalink connection), take off and landing assistance, intelligent orientation control to help if you get in trouble with your orientation and motor failure protection.
Other versions like the premium DJI A3 is also a good choice for large models. It's used on many filming rigs and lots of redundancy with multiple sensors redundancies and GPS add-ons and can support RTK options as well.
There are some tricky problems getting the DJI flight controllers to talk to a PC as the drivers you need don't install easily but once they are installed and working setup and configuration isn't too hard.
EagleTree Vector
Another option for those that will be using FPV to fly the model more often is the EagleTree Vector.
This is a little different from the other two options we've already touched on as it's designed from the bottom up to be integrated into an FPV system. It still offers mission-based planning, autonomous flight, great fail-safes, easy setup, and configuration supports both planes and multi rotors and is silky smooth to fly.
The big difference from the other two systems is that the OSD and setup are vector-based and use colour, making flying with Goggles a breeze. The entire setup can be done through the OSD itself so no need for an app for configuration at the field.
Excellent failsafe (especially when using S-Bus) and GPS modes, along with an array of mission planning tools make this one with a look for those FPV pilots out there that intend to fly a lot of their flight with FPV and want all of the critical data around the edge of the screen.
And the others?
Normally this is the part of an article where I talk about technology like iNavflight. iNav and other open source technology is excellent and provides a lot of the same features as the flight control systems above for about a 10-20% of the cost.
For me, if you're going to be putting a large multirotor in the air and carrying heavy expensive camera equipment then trying to use a less proven, all open-source technology could be a choice you may regret. I've been using iNavflight on wings and multirotors here with great success but would I trust a £400 SLR on a £800 multirotor to it? Not at the moment.
Standard LIPO battery packs can be used on the larger models as the efficiency of the motors and props mean that you don't need huge currents to fly these larger models. As we already looked at in part one last month, the motors and ESC you choose will decide on the voltage of the pack you need. 6s and larger are common on much larger multi rotors as they can deliver the same wattage the motor needs using lower currents for that longer flight time.
Connecting the packs in parallel will increase the flight time and allow you to mount the batteries in the spaces available in the frame and retain a good centre of gravity with all the other equipment on the model. Remember that doubling the capacity of the batteries on the model doesn't equal double the flight time. The extra weight of the second pack will use some of that extra power.
Ben uses the packs from Tattu in many of the larger models he makes for customers. He says 'They perform well, are designed to give the longest flight-times with larger mAh rating and the lower C ratings these models need. They also feature some cool touches like the capacity meter on the end too'.
The Frame and Landing Gear
Now we are getting into the meat of the setup and one of the trickiest parts of a build – choosing the frame and landing gear.
Sadly there are not a lot of frames on the larger class above 500mm until you get into the huge multi rotors that will weigh over 7Kg. There are options but you will need to spend time looking at them and making sure that it will support the mount you're interested in and have enough room to support the size of props that you need.
Ben talked about a few of the other things to look at when choosing your frame.
'I've used Tarot frames for models weighing 3-4Kg here, but the main considerations will always be the weight and stiffness of the frame. The key factor is the strength. Good quality carbon fibre tubes and alloy parts are usually good choices but you will need to look at the options for the landing gear and arms.
'Where possible choose a frame with folding arms, it'll make transportation easier. Think about the landing gear too, if you're only using a 2D gimbal then you can probably use fixed landing gear, if you want to use a 3D gimbal that can rotate then you need to look at retractable landing gear'.
Ben showed me how they have used DJI retracts on a few models where the customer wanted to be able to have a 360-degree unobstructed view from the camera.
The Radio (if you don't have one)
This is one of the few areas where you don't have to use any specialised kit. 'We tend to recommend the Futaba 14SG or the FrSky Taranis radio for the larger models. There is also a beautiful system from Jetti.' explained Ben.
There are a couple of things to consider when looking for a radio for your large Multirotor; you need to have enough channels to fly the model, select the modes you want, control any gimbal you're using and control the camera too.
For normal flying a flight controller will need the five basic channels – throttle, aileron, elevator and rudder plus at least one channel for the flight mode. Then you'll need two channels for a 2D gimbal and three channels if it's a 3D gimbal. Then you'll need a few more for the landing gear and camera control too.
'It's common for larger models used in filing to have two radios working side by side' Ben explained 'one for the pilot flying line of sight and another for the 'camera operator' to use to control the camera and compose the shots'.
Care should be taken when installing the receiver to make sure that the antennas for the receiver are routed well for maximum reception. If possible install the antennas at 90 degrees to one another.
'Make sure that your failsafe on the receiver is set up and configured with the flight controller you're using' Ben explained, 'test it thoroughly to make sure that the model will fail safe'. Wise words indeed, not just for the larger models.
The Video Kit
There are lots of options for the FPV equipment on a model like this but most often they are flown using the line of sight by the pilot. With the excellent GPS modes using the flight controllers we looked at earlier, you can 'park' the model in 3D space using the GPS and altimeter and then concentrate on the gimbal and camera.
Analogue FPV systems are inexpensive but provide relatively low-resolution images back to the ground station or goggles. The benefit with analogue is that you can easily add more than one camera (and even multiple transmitters) to the model and switch between the two. You can have one 'forward facing camera' for orientation and another mounted alongside the main camera in the gimbal to be able to 'see' the direction and framing of the photo or video.
If you're using a smaller camera like a GoPro then most of those action cameras do provide a 'video out' connection that can be plugged into the FPV transmitter.
Also available is the ability to use HD FPV systems from manufacturers like Connex. The one available for hobbyists is the Prosight system but they also provide much more expensive HD transmission systems for the professional.
The Connex Prosight runs at 720P60FPS and provides an excellent way to view the image from the model in real time. Sadly there isn't an HD DVR as part of the system but by using one of the many HDMI records on the marker you can easily ad one to record the footage.
Telemetry and Status Updates While Flying
Another useful element to look at is the support for the telemetry that your radio uses. Flight controllers like the PixHawk 2.1 and Vector have a telemetry cable that connects to the SmartPort plug on a FrSky receiver and allows all of the key data to be shown on the screen of the radio, attitude, battery health, distance, height, and other key metrics can all be read easily and alarms set up on the radio to let you know if you're about to have a problem.
Using something like the EagleTree Vector allow you to 'see' all of the critical data on the FPV screen so you know exactly what's going on.
Consider how you want to fly and what devices you expect to have with you when you fly. Will it just be an iPhone? Will you take a tablet PC, iPad or Android device to the field? What applications exist for you to manage setup, program and monitor the model as it flies?
Often to monitor the model as it's flying relies on a radio connection. Connections using Bluetooth are short range, Wi-Fi only slightly better. Systems that use frequencies like 433 MHz in the EU and 915 MHz in places like the USA are excellent for maintaining a solid radio connection for the telemetry. Consider a telemetry radio setup for the model you're making and some kind of ground station too, it'll allow you to see exactly what's going on as you fly.
The problems facing a builder of a 250 class quadcopter pail into comparison when looking at building a 2kg model with all of the above.
As we've looked at over these two articles there is a lot to consider. Builders and pilots tend to get familiar with one set of technology and use that to the exclusion of all others. As we've already seen, not all of the technology is good in the same areas. One flight controller may be amazing when used with OSD systems, another has excellent telemetry and simple mission planning.
There are excellent multiple choices for every part of a large multirotor build now but being clear on what you want the model to do for you will help you make the right choices. We need to go back to where we started, and those first principles we looked at. Form follows function so the time you spend at the start will set the course and the decisions you make as you build.
Don't forget that there are experts like Ben about. If in doubt use these resources and patronise these businesses as you may need them after the sale if you get stuck too! Hopefully, you now have an idea of the areas of consideration when looking to build a much larger model. As always – Happy flying!
Written by Painless360


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Open Streets TO readies Toronto street promotion
Urban recreation organization Open Streets TO is preparing to conduct an initiative by which a temporary public park will be created in downtown Toronto. The initiative will be conducted in association with the City of Toronto and will take place on sections of Bloor and Yonge Streets on Aug. 19 and Sept. 16. On those dates, parts of the streets will be closed to vehicles in an effort to encourage members of the community to interact with each other. In addition, 5,000 square-feet of grass will be installed near the Yonge and Bloor intersection. The installation will include play areas, street furniture and yoga classes conducted by program sponsor Lululemon. Other sponsors include CentreCourt, the Downtown Toronto BIA, 8 80 Cities and Bennet Jones.
"Open Streets is about getting out, being active and connecting people in the city without the barriers and stresses created by vehicle traffic," said David Simor, spokesperson for Open Streets TO. "We are ecstatic to be back for our fifth year, offering Torontonians a chance to experience our beloved city in ways they never could before. We are excited to appeal to participants young and old and to bring together Toronto's diverse neighbourhoods in a celebration of physical activity and unity."


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Football Position and Length of Play Affect Brain Impact
Results from a newly published UNC study co-authored by MD/PhD student Michael Clark showed that non-speed players with a history of recurrent concussion had lower white matter integrity and lower measure of activation during cognitive tasks.
October 31, 2017
UNC researchers have found that damage to white matter in the brains of former college and professional football players due to recurrent head impacts can be related to playing position and career duration, according to a new study published online in the journal Radiology.
Most previous research on head impacts in football has focused on cognitively impaired former football players. This is the first neuroimaging study to compare former football players with no evidence of cognitive impairment to analyze the effects of different playing histories and concussion exposure.
"Our study, by including both former collegiate and professional players, gives us the ability to examine career duration and playing position along with concussion history," said study author Kevin Guskiewicz, PhD, research director for the Center for the Study of Retired Athletes at the University of North Carolina at Chapel Hill. "By doing so, we found that these factors are all important when considering the long-term effects of playing football."
The research team recruited 64 former collegiate and professional football players, aged 52 to 65. Half of the former athletes played only college football, and half continued on to the professional league. Half of the former players reported three or more prior concussions, while the other half reported one or no prior concussions. The researchers recruited an equal number of speed and non-speed playing positions. The non-speed positions consisted of offensive or defensive linemen.
Two MRI techniques—diffusion tensor imaging (DTI) and functional MRI (fMRI)—were used to examine 61 of the former players. MRI data from the other three players were excluded due to excessive movement or inability to complete the MRI exam. DTI was used to analyze white matter structural integrity, while fMRI was used to assess brain function while the players performed a memory task.
"While DTI and fMRI have been used previously in the field of concussion research, we are among the first to combine the two techniques," said co-author Michael Clark, a seventh-year MD/PhD student in the department of Allied Health Sciences. "We were interested in how white matter and the ability to recruit brain resources to complete a memory task might be affected by head impact exposure in terms of career length and the position played. By using two different and complementary types of MRI, we were able to see the relationship between structure and function, both of which are affected by head impact exposure.
The results showed a significant interaction between career duration and concussion history. Former college players with three or more concussions had lower integrity in a broadly distributed area of white matter compared to those with one concussion or less. However, the opposite was true for former professional players.
The researchers speculate that players with a long career duration, exposure to recurrent concussive events, and who are cognitively normal in their late 50s may not be reflective of the highly exposed former professional football player population as a whole.
"We're not exactly sure why this is the case for the former pros," Clark said. "It may have to do with the sample of athletes we recruited into the study. But the findings could suggest that a career with additional exposure to football is not necessarily worse than a shorter duration of exposure."
The non-speed players with a history of recurrent concussion had reduced integrity in the frontal white matter and lower measure of activation during the fMRI task than those with one concussion or less. This was not the case for the speed players.
The interactions observed between concussion histories and playing positions suggest there may be important differences in the mechanisms of injury between speed and non-speed players. The magnitude, location and frequency of head impacts in football differ by position. Offensive backs experience impacts at greater acceleration. Linemen, however, tend to experience a greater overall frequency of impacts, and have the greatest proportion of impacts to the front of the helmet. The high proportion of frontal impacts experienced by non-speed players may result in more localized damage to frontal white matter tracts as compared to the more variable impact locations experienced by speed position players.
"These findings suggest the playing position of an athlete may change the effects of concussions on the brain," Guskiewicz said. "The mechanisms of concussions in non-speed players are fundamentally different from those of speed position players, suggesting that perhaps position-specific helmets are warranted."
The researchers added that more work is needed to better understand the results and to determine the underlying mechanisms regarding how subconcussive and concussive impacts affect brain health later in life.
Collaborating with Guskiewicz and Clark were Eleanna M. L. Varangis, M., Allen A. Champagne, Kelly S. Giovanello, PhD, Feng Shi, PhD, Zachary Y. Kerr, PhD, and J. Keith Smith, MD, PhD.
Media Contact for UNC School of Medicine: Mark Derewicz, 984-974-1915, firstname.lastname@example.com
Media Contact for the UNC College of Arts and Sciences: Kim Spurr, 919-962-4093, email@example.com


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Vaginal mesh is causing life-changing and permanent injuries. Manufacturers of many types of vaginal mesh have sent a clear message: their profit margins are more important than the safety of their consumers. These companies have repeatedly failed to conduct adequate research before releasing their product onto to the market. The tragic result of defective vaginal mesh is that users are often oblivious that they are being harmed until the product has already subjected them to irreversible injuries.
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A professional painter will also understand the materials which are needed to do the job correctly. Which primer will offer the correct coverage? Latex or oil? Which primer foundation is required? What paint base? Spray or roller?
A professional painter will have the ability to recommend materials which are better to get the look you need, while preventing any damage to your surfaces. With this information, you can attain a higher quality finish that will endure.
For outdoor tasks, a specialist will know the ideal weather, temperature and sun conditions to complete the job with the best results. Stains respond differently in direct sunshine than when it's overcast, and at several temperatures. While rain obviously impacts the job, heat and humidity can also affect the quality of exterior paint finishes.
Climbing on ladders while trying to apply paint properly is a skilled job that takes careful attention and focus to avoid serious harm and damage. The higher the website which requires painting, the greater the danger of an crash. For interior projects with high areas or outside jobs, a professional painter will have all the tools and expertise necessary to perform the job safely and correctly, including the proper size and layout of ladder and scaffolding.
Your time is precious and painting yourself requires a significant quantity of time. Having a professional painter and decorator take care of the work for you can save you days and days of effort, and can usually be done in a much shorter period of time.
A research from Trinity College Dublin suggests that the average Irish person needs 28 hours per day to accomplish all his or her tasks. Prevent including a paint job to this and talk to a professional painter about your requirements.


text: The Golden Fox Moc Toe Sport Wedge Work Boot is made the finest smooth finish full grain leathers. The full grain leather upper of these boots provide the durability and comfort you need when working. The leather's 2mm thickness is primarily chosen for heavy workloads and hard terrain, full-grain leather is extremely durable, water resistant, and supportive. Full grain leather is capable of absorbing water and humidity while remaining dry. The treatment process gives the leather an elegant appearance that will develop a unique patina and soften over time. Because more finishing material is used to treat the leather, natural characteristics will be less apparent. To assemble the footwear, Goodyear Welt Construction is utilized. Goodyear Welted shoes are extremely tough, known to be the most durable footwear construction. The method of Goodyear Welt stitches the upper fabric, lining, and mid-sole together. The construction provides excellent performance, as well as lateral stability in boots. For reliable protection, the 6" Moc Toe boot combines an oil resistant Rubberlon sole with an eco-friendly Bontex footboard. The footboard is supported with a steel shank providing additional support and stability. The shank forces the appropriate break at the ball of the foot, helping with arch support and relieving pressure off of your feet. Golden Fox strives to build boots with maximum strength and durability. Imported.


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Church Software
Bible ProductsWritten by Jeremy Horelick
Millions of faithful Christians turn to Bible products for insight into the Word of God. By reading the Bible these followers seek to better understand how they should live in an increasingly complex world. Many times, however, the Bible, on its own, is opaque or full of vague passages that might be interpreted differently from scholar to scholar.
While some Christians do have the time and the will to undertake their own formal study of Latin, Greek, Hebrew, and Aramaic--the languages in which the Bible was written--most people are forced to take their translations on faith alone. Hence, there are a slew of Bible products out there designed to explicate the difficult passages. Some of these contain semantic issues that only trained scholars can decipher, while others are rife with troubling moral and ethical questions.
Seek Guidance with Bible Products
Whatever the reason may be for your renewed sense of spirituality, Bible products can help. You may have read the Bible in Sunday school as a child and recall its ability to comfort in times of need, but have since forgotten its most instructive lessons. Or you may already be familiar with its tales and simply need a refresher for a more complete and satisfying practice. Perhaps you're now dealing with turmoil for the first time in your life and need help getting through your dark spell.
Bible products such as CDs, DVDs, and books help not only translate specific passages, but distill essential messages from Biblical tales. The book of Job may help doubters and skeptics feel a sense of connection in a world that's often isolating and indifferent. The tale of Abraham and Isaac explores notions of sacrifice and trust. The Gospels preach the importance of acceptance, especially toward those of differing beliefs and legacies.
Other Types of Bible Products
Aside from the computer programs, Bible study software, and religious audio CDs, there are the Bibles themselves. You may have been brought up on the King James Version, the Alexander Scourby Bible, or any other of a number of versions out there. Each one is different in its own right, with different idiomatic phrases, included chapters, and styles of wording. In fact, the basic message of any given story can change depending on how it's translated.
Translations take into account not just the author of a given Bible but the language itself. As the most widely circulated book in the world, the Bible has found its way into every language you can imagine. There are Spanish Bibles, French Bibles, Vietnamese Bibles, even Arabic Bibles. A sizable portion of the Arab world is Christian, meaning Bible products are just as widely embraced there as is the Koran.
Your Bible Products Resource
Whether you're merely leafing through the Bible with a detached curiosity or participate in a weekly Bible study, the words you're reading contain stories and wisdom that have inspired billions of others worldwide. At the very least, then, you owe it to yourself to investigate the texts that have held such deep meaning for so many people. Even if you're not particularly pious, you can glean valuable insights about modern-day social and political issues by understanding what underlies these peoples' beliefs.
In the pages ahead, you'll learn a little bit about the Bible's history, its various adherents, and the stories contained therein. You'll also learn about Bible products that make understanding God's Word easier, whether you're new to Christianity or a lifelong worshipper. If you come away with anything, perhaps it will be an appreciation for the interpretive differences that manage both to divide and unite the Bible's followers all around the world.


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BlogAll Blog Posts | Next Post | Previous Post
Be-Delphi developer event 2019 in Belgium, BrusselsBookmarks:
Thursday, October 31, 2019With great pleasure we announce a brand new edition of the Be-Delphi developer event.
You will not only meet & network with your fellow Delphi developers from the Benelux.
But Embarcaderos Jim McKeeth Chief Developer Advocate & Engineer and José Léon Serna - Creator of Delphi for PHP/HTML5 Builder and former Director of Engineering and Branch Manager at Embarcadero Technologies, will be present to!
José Léon Serna will introduce a brand-new and ground-breaking product from TMS software that will open the world for Delphi developers and vice versa!
For the first time with this Be-Delphi edition, we will have an optional geek night the evening before the event. All attendees of the Be-Delphi event are entitled to join us free for more fun on Wednesday-evening. Full program for both days can be found here.
Agenda09h00 - 09h15: Welcome & keynote (Be-Delphi)
Filip Lagrou, organizer of Be-Delphi welcomes attendees and provides the latest agenda details and warms up the audience.
09h15 - 10h15: Legacy Delphi projects (Serge Pilko)
Serge Pilko and his team from Softacom has tons of experience moving forward legacy Delphi code to new and modern Delphi versions. Serge will share all tips, tricks, techniques, pitfalls to take in account when moving forward legacy Delphi projects to the latest versions taking advantage of Windows 10, unicode, cross-platform and the latest RTL & VCL features.
10h15 - 10h45: Coffee break
10h45 - 12h00: Targets for TMS WEB Core (Bruno Fierens)
The CTO of TMS software, Bruno Fierens, explains and shows how TMS WEB Core can be used to go to 3 targets: regular web applications, cross-platform installable mobile applications for iOS + Android and installable desktop applications for Windows + macOS + Linux and this all from the same code base with TMS Web Core.
12h00 - 13h00: Warm lunch
13h00 - 14h00: FireDAC (Jim McKeeth)
Explore with Jim McKeeth the ins and outs of FireDAC to get high performance and flexible access to almost every database on the planet.
14h00 - 15h00: TFrameStand & TFormStand (Andrea Magni)
Make multi-form handling in your FireMonkey applications easy and shine with the opensource TFrameStand and TFormStand developed by Andrea Magni himself.
15h00 - 15h30: Coffee break
15h30 - 16h30: Brand-new & Ground Breaking (José Léon)
José Léon will take the wraps of a brand-new and ground-breaking product for the first time in the Benelux that will open the world for Delphi developers and vice versa. Be there and be amazed!
16h30 - 17h30: FMX Linux (Jim McKeeth)
Since FMXLinux is included in Delphi Enterprise and Architect editions, it is now also possible to use the FireMonkey framework to create Linux client applications. Jim McKeeth shows and covers all details to get you productively create Linux client applications from Delphi.
LocationThe event will take place at the peaceful Hotel Chateau du Lac - Genval, Belgium.
Facilities for hotel rooms at the event are optionally available for attendees. Book your hotel room at Chateau du Lac with a discount thanks to Be-Delphi via link below!
This is your chance to meet and share ideas with your fellow Delphi developers from the Benelux. So don't waste time and be one of the first to secure your place at the Be-Delphi event.
Masiha Zemarai
This blog post has received 6 comments.
1. Friday, November 01, 2019 at 3:16:58 AM Will this "...brand-new and ground-breaking product..." be delphi only, or it is something you will have available for Lazarus too.
I taking some decisions but the pascal stuff if there is some will be Lazarus only from now on.
I taking some decisions but the pascal stuff if there is some will be Lazarus only from now on.
Vargas Moctezuma Sandoval
2. Friday, November 01, 2019 at 5:43:23 PM The good thing is you won''t be required to make choice between these.
Bruno Fierens
3. Friday, November 01, 2019 at 7:00:38 PM Intriguing :-)
Well, I''ll keep an eye on this, thank you !
Well, I''ll keep an eye on this, thank you !
Vargas Moctezuma Sandoval
4. Saturday, November 02, 2019 at 6:10:44 PM ... my VS Code is ready for a "brand-new and ground-breaking plug-in" ;)
Schachtner Andreas
5. Monday, November 04, 2019 at 8:59:51 PM I heard some vcl components that cannot be used in C++ Builder, who are them? Maybe the bussiness components which heavily rely on RTTI of Delphi? In every conference, nobody talk about C++ Builder?
Best regards
Best regards
6. Tuesday, November 05, 2019 at 7:47:56 PM TMS Aurelius, TMS XData, TMS FixInsight, TMS WEB Core and TMS Plugin Framework are products only for Delphi. These products cannot be used with C++Builder for various technical reasons.
Other products can be used with both Delphi & C++Builder.
Other products can be used with both Delphi & C++Builder.
Bruno Fierens
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With the insight of running a 100% cloud Platinum practice, Heather's a Chartered Accountant and Content Strategist helping Cloud App solutions create and deliver compelling technical content that resonates with the accounting and bookkeeping businesses community.
She's educated over 1 million, via:
- Her instructional YOUTUBE channel,
- Her SPEAKING roles, including panel participation, facilitation, and presentations.
- Her NEWSLETTER sharing curated content, news and events from the Cloud Apps community: https://heathersmithsmallbusiness.com/newsletter/
- Her Cloud Stories PODCAST exploring the stories behind the people who build or use Cloud Apps that extend the capability of online accounting software: https://heathersmithsmallbusiness.com/podcast/
- Her MASTERMIND community which shares efficient automation, integration, business process workflows solutions leveraging Cloud Apps, https://www.facebook.com/groups/XeroMasterMind/
- Her Cloud Advisors MEETUPS showcasing Cloud Apps that extend the capability of online accounting software: https://heathersmithsmallbusiness.com/meetup/
Plus, she's written nine business books including:
- Multiple books withing the Xero for Dummies series.
- Learn Small Business Start Up in 7 Days
- Learn MYOB in 7 Days
Heather is a Chartered Accountant, a fellow of the Association of Chartered Certified Accountants (ACCA, in the UK) and a fellow of the Institute of Certified Bookkeepers (ICB), and holds a bachelor of commerce degree.
She is an advisor to numerous Cloud App businesses globally.
Heather's practice fits in her handbag, and she believes advisors can work from anywhere, and support clients anywhere, by honing their ability to offer services online.


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Jerzees Super Sweats 1/4-Zip Pullover With Cadet Collar
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Features: Pill-free 50% cotton, 50% polyester NuBlend; double-needle cover-seamed neck, armholes, shoulder and waistband; 1x1 ribbed cuffs and waistband with spandex; bronze-color zipper; 9.5-ounce.
Price includes embroidery on left chest.
Unisex Sizes and Colors Available:
Small - 2XL: All colors are available
XXL's are an additional: $2.00
Style #: 4528857386113


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Date Posted
The Electrical Workers Minority Caucus (EWMC) NYC Chapter held a comedy event at the Joint Industry Board Auditorium last month. The event included a tribute to Local #3 members highlighting their volunteer work and experiences in Angola, bestowing the "Best Dressed Award" to its honoree, and enjoying an evening of great entertainment with great comedians for a great cause.
The funds raised at this year's event is used to help offset the costs incurred by attendees of the national IBEW EWMC conference held every year on Martin Luther King Jr. weekend.


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Barking Riverside and Thames View residents are invited to the second annual Big Barking Riverside Picnic on Saturday 6th July, between 12 noon and 4pm!
The community event marks the return of Barking Riverside's very own pop-up beach. The grassy riverside adjacent to the project office and the public footpath will be transformed into a sandy beach all summer, allowing little ones to build sandcastles and families to enjoy riverside views throughout the summer (opening times soon to be announced).
Sponsored by Pinnacle Places, the picnic on the 6th will include a host of activities, from Zumba classes and giant games to creative writing and face painting, run by local groups, including Triangoals and Creative Wellness. For the first arrivals, limited edition picnic hampers will be handed out, stocked full of healthy treats. Guests are also welcome to bring their own picnic.
Children under 16 must be accompanied by an adult.
Parking is not available. The EL1 bus stops just outside the Barking Riverside Project Office and runs 24/7.
When: Saturday 6th July 2019, 12 noon – 4pm.
Where: Along the river next to the Barking Riverside Project Office, Project Road, Barking IG11 0YP.


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Feel hope 希望を感じて /ピアノ自作譜
I wrote this song imaging lyrics on the melody line.
That are including words "hope,brightness, love"
Because my palm is small, octave movement is not good and some part chords are not being pressed well. But I don't want to change to be eazy for me.
"Feel hope" 希望を感じて piano original tune
If you feel hope, I'm happy\(^o^)/


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See these serviced offices, executive suites and virtual offices in Toorak and Caulfield Melbourne. See also Serviced Offices in South Yarra which is the next suburb going toward the city.
Serviced Offices Toorak & Caulfield, Melbourne
Serviced Office Listings
- Serviced Offices: 23 Milton Parade,Ground Floor, Malvern, Malvern Melbourne 3144
Grow and nurture your business in this vibrant complex, where you can enjoy a strong sense of community and personalised support services on-site. Centrally situated in the heart of Malvern, this centre offers a wide range of office solutions. You'll be able to benefit from a variety of premium amenities, ranging from personalised administration services, all the way to the on-site gymnasium and shower facilities. You can also take advantage of the boardrooms available for hire, the comfortable breakout areas and the communal kitchens. Just looking for an "office on the go"? This space has a virtual office package to suit you. Make use of the centre's address to receive your business mail and use this service for your call handling needs – the professional staff are available for you at all times during business hours. Click here for more details and free, no-obligation enquiry service.
- Serviced Offices: 242 Hawthorn Road,Caulfield,, Caulfield North Melbourne 3162
This centre provides a complete range of professional office services in a friendly and highly efficient environment. It has abundant natural lighting and has 24 modern, furnished, serviced offices. All serviced office clients are provided with the business flexibility you need, from 24-hour access and flexible terms to free use of the boardroom and assistance with business administration so you can focus on everything else. Virtual office solutions offer you a prime Caulfield business address with a dedicated telephone number to which calls are professionally answered to the name of your business and transferred or converted to email, incoming fax and mail handling, premium access to the boardrooms, and access to photocopying and scanning facilities. Click here for more details and free, no-obligation enquiry service.
- Serviced Offices: 191 Balaclava Road,Caulfield,, Caulfield North Melbourne 3161
This centre provides a complete range of professional office services in a friendly and highly efficient environment. It has 20 modern, furnished, serviced offices, and all serviced office clients are provided with free use of the boardroom. Premium amenities are available and include 24 hour secure parking, access to three different meeting rooms with the capacity to host six-twelve people, and wireless high speed internet. Also providing you with the business flexibility you need your space can be accessed 24 hours a day within a flexible short or long term contract. Administration support is also offered with dedicated phone lines that are answered by professionals under your business name who can either transfer the call to your mobile or convert the message to text so the virtual office solution can suit your job style. Click here for more details and free, no-obligation enquiry service.
- Serviced Offices: Waverley Business Centre,21-23 Aristoc Road, Glen Waverley, Glen Waverley Melbourne 3150
This serviced office complex comprises 56 fully furnished office suites ranging in size from 1 to 8 persons. Each office is fully furnished and ready for business with state of the art digital phone system and broadband internet. You also have access to a boardroom with large screen LCD TV for presentations, projector and whiteboard and meeting rooms and on-site car parking. Let our experienced staff take care of your business needs and assist with support services such as telephone answering, extensive secretarial services, greeting clients and more. Adjoining the office complex is a fully serviced warehouse. With an on-site manager and container access, we can offer convenient commercial and records storage. Click here for more details and free, no-obligation enquiry service.
- Serviced Offices: 321 Koornang Road,Carnegie,, Carnegie Melbourne 3163
This business centre has 10 years of experience providing a professional personalized management and assistance in the serviced office industry. The new centre offers seven offices ranging from 11- 50 sqm. Being a boutique establishment they aim to provide a more personalized service to suit the needs of the tenant. The centre provides a full time receptionist to deliver a service to assist your businesses. The carpets and partitioning have all been installed in January 2015. Leases can be obtained for a 6 month period +. The area has no parking restrictions and boasts numerous parks and sporting facilities including a heated indoor pool in a peaceful region. Click here for more details and free, no-obligation enquiry service.
Categories: Melbourne Serviced Offices
See more pages about: Serviced Offices AU & NZ
Virtual meeting rooms and webinars
Check out Tips & Tricks on GoToMeeting Blog


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Dysfunctional Uterine Bleeding (DUB) is abnormal bleeding that occurs within or outside the menstrual cycle, due to malfunctioning of the working mechanism of the hypothalamic-pituitary axis, ovary, endometrium without organic abnormalities of both genital and ekstragenital.
Dysfunctional Uterine Bleeding (DUB) can occur in ovulatory cycles, anovulatorik or in a state with persistent follicles.
In the ovulatory stage, bleeding may occur in mid-menstrual or simultaneously with menstruation. Bleeding is due to the persistent corpus luteum with low estrogen levels, while progesterone continues to form.
In anovulatorik cycle, is common during perimenopause and the reproductive period. The basis of the bleeding that occurs in cycles anovulatorik this is because no ovulation, the corpus luteum is not formed. By itself will be low levels of progesterone and estrogen overload. Because estrogen is high then the excessive proliferation of endometrial experience (hyperplasia). With low levels of progesterone, the endometrial thickness was not followed by the formation of a good buffer, rich in blood vessels and glands. These networks are fragile, easily letting go of the surface, and cause bleeding. Bleeding in one place are recovering, bleeding arise elsewhere, so that bleeding does not occur simultaneously.
So the basic anovulatorik bleeding in this case due to:
- The endometrium is thick and brittle
- Release of the endometrium does not coincide
- No rhythmic vasoconstriction
- There is no tissue collapse.
Dysfunctional Uterine Bleeding (DUB) on the state of persistent follicles, often encountered during perimenopause, rare in the reproductive period. Because of the continuous influence of estrogen, endometrial hyperplasia will experience both types of simple hyperplasia, or atypical adenomatus. Adenomatus and atypical types of this malignancy is pembakal (pre-cancerous), so it needs special handling.
Clinical Features
- Bleeding can occur at any time in the menstrual cycle
- Bleeding can be a little bit, continuous or multiple and repetitive.
- Most often encountered during menarche or during perimenopause.
The cause of Dysfunctional Uterine Bleeding (DUB) is known with certainty is difficult
Dysfunctional Uterine Bleeding(DUB) is common in:
- Polycystic ovary syndrome (PCOS)
- Obesity
- Immaturity of the hypothalamic-pituitary axis-the ovaries, for example in pre-menopause.
- Psychiatric disorders, and others.
It is important to conduct a careful diagnose, to ask the age of menarche, menstrual cycles after menarche, length and amount of menstrual blood. Also need to be asked anyway background and family life back latat emotional.
General Examination
Aimed to determine the possibility of abnormality is the cause of bleeding. Consider the possibility of metabolic disease, other systemic diseases or chronic diseases including hemostasis disorders.
Gynecological examination
- Examination in to get rid of organic abnormalities that can cause abnormal bleeding, for example: cervical polyps, ulcers, injury, erosion, inflammation, tumors, abortion, malignancy, and others.
- To make a diagnosis on the girl does not need to be done curette.
- In women who are married, curettage should be performed for diagnosis.
- On histopathological examination, usually obtained endometrial hyperplasia.
Diagnosis APPEALS
All disorders that can cause abnormal bleeding from the uterus.
Treatment Principle
- Makes the diagnosis of Dysfunctional Uterine Bleeding (DUB), by removing the possibility of organic abnormalities.
- Stop the bleeding
- Regulate menstruation returned to normal
- When anemis (Hb <8 g%) were given transfusions.
Stop the bleeding
- Curettage (no need to Hospital Admission, except when going in tranfusion) Done for patients who are married.
- Drugs (priority of choice, according to serial number):
a. Estrogen
Usually selected natural estrogen, such as conjugated estrogens (conjugated estrogens), for example: Estradiol valerate (Premarin). Estrogen type is more advantageous, because it does not burden the liver and did not increase levels of renin and blood clotting disorders. Another type of estrogen is ethinyl estradiol. This type of estrogen is metabolized in the liver, so liver function is more disturbing.
- When bleeding a lot (profus) Hospital Admission, given conjugated estrogen (Premarin) at a dose of 25 mg iv, repeated every 3-4 hours, giving a maximum of 4 times.
- If the bleeding is not a lot, can be given: 20 mg estradiol Benzoas i.m. Conjugated estrogens 2.5 mg per oral, 7 - 10 days.
b. Combination pillPurpose: to transform the endometrium into pseudodesidual reaction.Dosage:
- When bleeding a lot (profus) can be given 4 x 1 for 70-10 days, followed 1 x 1 for 3-6 cycles.
c. Progesterone
Purpose: to provide the balance of influence of estrogen. Progesterone is a type of progesterone that elected a molecule resembling natural progesterone. Included in this type is Medroksi progesterone acetate (MPA) and Diprogesteron. The type of progesterone that androgenic (testosterone derivatives) are not widely used, because it has androgenic effects (acne, hair growth, etc.), and may decrease HDL cholesterol.
- MPA 10 -20 mg per day (Primolut N), for 7 - 10 days or Norethisteron 3 x 1 tablet, 70-10 days.
- If there are contraindications of estrogen, may be given injections of 100 mg im Progesterone, in order to stimulate the endometrium and resilience in vasomotor rhythmic contractions. For this purpose can be used DMPA.
d. Compounds antiprostaglandin
Use antiprostaglandin compound is mainly given to patients with contraindications to estrogen and progesterone, such as liver failure or malignancy. Drugs that are used eg mefenamic acid with a dose of 3 x 500 mg per day. Regulate Menstruation Immediately after the bleeding stops, continue therapy to regulate menstruation.
To set this period can be given:
- Oral pills for 3-6 months
- Progesterone 2 x 1 tablet for 10 days, starting on day 14 -15 menstruation.


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Cute Smart Star of World
Saturday, 30 April 2011
New Models For 21st Century
It is high time that these models do something new in fashion. They could be thicker, muscular, to play or to perform some acrobatics on the catwalk. See for example these girls. They are beautiful! Imagine them just on the catwalk or a magazine.
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Cute Smart Star of World
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