text:
It's wedding season! Which means that my husband and I drove 19 hours across the country on Friday to be able to share a special weekend with two fellow physical therapists and graduates of Pacific University, Claire and Ernesto, who got married on Saturday. These two are amazing. They are hilarious, kind, and they are the type of people you just instantly feel good being around. Their wedding was pretty incredible too. The location was gorgeous, I cried and laughed in the perfect ratio during the ceremony, and the tacos for dinner were heavenly. And instead of a champagne toast, the couple opted for tequila shots which I thought was a perfect touch. But more than all of that, the friends and family of the couple were all so welcoming and fun, and it was a bonus that a huge portion of guests were physical therapists I went to school with so it was a nice little reunion.
We even got to meet some babies that have joined our crew in the last few years!
I just love weddings in general. So much happiness, food, and dancing.. it's perfect. I also love the chance to dress up at weddings. I'm a pretty casual person day to day, most often rocking yoga pants and a messy bun, so the chance to put on a dress and let my hair down is nice every now and then.
And then there are the heels. If you've ever put on heels yourself, you know that they are not always the most comfortable. And as a physical therapist, I know fully well that they are not great for your body. BUT, everything in moderation, and I find it fun to throw on some cute shoes and stand several inches taller from time to time. If you're like me and are too stubborn to choose sensible shoes for special occasions, it's at least a good idea to have some strategies to make amends to your body when you wake up a little sore after dancing the night away on stilts you're not used to.
One of the many ways heels alter your alignment and body position is that they keep your calf muscles and Achilles tendon in a shortened position, which can cause tightness in these areas. It should feel really good to give this area some attention once you're back to your flat, supportive shoes.
Let's start with some stretches. Your calf muscle is actually made up of two layers. The deeper layer is called your soleus and the more superficial layer is called your gastrocnemius. These muscles both join into your Achilles tendon and ultimately attach to your heel bone. But, because they are two distinct muscles, there are two different stretches to most effectively target each one.
First, for your gastrocnemius, start in a slightly lunged position with your back leg (the leg you are stretching) completely straight, your heel pressing to the ground, and your toes pointing straight forward. You should feel the stretch in your calf area, more up towards your knee. Then, to stretch your soleus, simply bring your back foot forward a little bit and bend your knee until you feel a stretch. Continue to make sure your heel stays down to the ground and your toes point forward. You'll still feel the stretch in the back of your lower leg but it should be a little bit lower towards the ankle compared to the first stretch. Make sure to do both legs, and as a general rule you can perform each version of the stretch 2-3 times, holding for about 30 seconds each time.
If you are still feeling tight in your calf muscles and/or feet, you can also do some self massage/release with something like a tennis ball, lacrosse ball, or foam roller. In my case, I'm borrowing my dogs' ball because that's all I brought with me on this trip. Basically, just put the ball under your calf or under your foot and roll on it. Stay away from bony areas and the soft spot behind your knee, but otherwise feel free to work your way up, down, in, and out on the muscle, working any tight areas out. If a spot feels particularly tight, maybe spend a little bit of extra time there. Remember to breathe and try to relax the muscle you are rolling to get the best benefits. It is not necessarily comfortable as you are doing this, but it can feel much more loose once you are done. If you want a little extra out of your rolling, you can put your opposite leg over the top for added pressure or experiment with moving your ankle while you keep force on a sore spot in the calf.
Well, I'm gonna run for now (which would have been impossible in my heels on Saturday!) Congratulations to all of the 2018 lovebirds out there, and good luck to all of you ladies braving less than practical footwear!


text:
UK's Freesat Selects Intertrust's ExpressPlay CA to Secure UHD Broadcast Content
Las Vegas, United States – January 8, 2018. Freesat, the UK's subscription-free satellite TV platform, has selected Intertrust Technologies' ExpressPlay CA™ content security technology to manage and protect their ultra-high definition content in 2018.
ExpressPlay CA is Intertrust's new cloud-based conditional access security technology designed specifically for modern broadcasters. The technology keeps digital rights secure by ensuring that only licensed users can access the content they are entitled to, fighting piracy and keeping illegal viewing at arm's length. ExpressPlay CA uses an open standards-based digital rights management system (DRM) known as Marlin to protect and manage content, and is available on a broad base of set top boxes and connected televisions.
"ExpressPlay CA is a powerful new content protection technology," said Alistair Thom, Managing Director of Freesat. "Its advanced DRM software engine allows us to protect our ultra-high-definition broadcast streams in an effective manner, leading to a significantly lower price point. This in turn allows us to deliver the best possible high-value entertainment experience for our customers."
Deployed in hundreds of millions of consumer electronics devices around the world, ExpressPlay is a versatile media monetization platform that provides leading rights management and content security capabilities. Intertrust is widely known as the inventor of DRM. The technology is used to protect and manage digital media content around the world, and the underlying Marlin DRM engine is used in national ecosystems in the UK, Italy, China and Japan.
"We are delighted to support Freesat in their UHD content protection initiatives in 2018 and beyond" said Talal Shamoon, CEO of Intertrust. "We designed ExpressPlay CA to support broadcasters like Freesat, to bring the power and cost efficiency of DRM to the conditional access world. Given our footprint in connected TVs and set top boxes, we can deliver a seamless, secure experience that scales and grows with broadcasters' needs."
About Freesat
Freesat is the UK's subscription-free satellite television platform, offering over 200 channels of brilliant free recordable TV together with the latest streaming services, including catch-up and pay-as-you-go. First and foremost, we're about giving our viewers content, choice and amazing value. But we're also innovative, ambitious and agile, whether that's adding new services on our platform, finding new ways to help the channels that work with us, or exporting our technology to broadcasters in new territories. We invest our profits back into the business, helping to maintain a great user experience for all our customers.
Established in 2007 by the BBC and ITV, Freesat reaches 2 million homes each week and is available via TV and set-top box. Our customers have access to a wide range of channels providing entertainment, news, music, and children's programming and on-demand and catch-up favourites such as BBC iPlayer, ITV Hub, All4, YouTube and Netflix.
Our user interface and management platform, Metaphor provides international TV companies with connected TV solutions. We are a founding member of the Free TV Alliance in Europe and in 2016 we launched an audience analytics and insight service in association with TVbeat.
About Intertrust
Intertrust provides trusted computing products and services to leading global corporations – from mobile and CE manufacturers and service providers to enterprise software platform companies. These products include the world's leading digital rights management, software tamper resistance and secure data platforms in the energy, healthcare, and IoT (including industrial IoT) sectors.
Founded in 1990, Intertrust is based in Silicon Valley, with regional offices in London, Tokyo, Seoul, Beijing, and Mumbai. The Company has a legacy of invention, and its fundamental contributions in the areas of computer security and digital trust are globally recognized. Intertrust holds hundreds of patents that are key to Internet security, trust, and privacy management components of operating systems, trusted mobile code and networked operating environments, web services, and cloud computing.
Additional information is available at intertrust.com, or follow us on Twitter or LinkedIn.
Media Contact
Actual Agency for Intertrust
Brian Regan
+1 908-399-7161

subset: commoncrawl


text:
Protection Advisor - West Midlands area - Self-employed with a realistic OTE of £50,000 - £70,000+
Our client specialises in the selling of protection including life, critical illness, income protection, and family insurance.
Due to continued growth of the company, the client is looking for outstanding advisors from a mortgage/protection background.
This a home based telephony role with quality appointments provided for you and a opportunity to join a company with a fantastic reputation.
A competitive commission split on business banked from the leads provided, with an enhanced lucrative commission split from business that is self-generated.
Previous protection experience in a telephony role is desirable.
Apply on-line or if you would like more information on this role, or any role within the mortgage market please contact Mithun Bhagwan - Specialist Consultant for the Reed Mortgages Recruitment team.
REED Mortgages - The UK's leading specialist recruiter in Mortgage Advice, Support, Underwriting, Compliance and BDM roles.


text:
Laser NDT methods based on interferometric
imaging, primarily holography
and shearography, have seen
growing acceptance since the
mid 1980's. With the large increase
in the use of composite materials
and sandwich structures, the
need for high speed, large area
inspection for fracture critical,
sub-surface defects such as
disbonds, delaminations, sheared
core or non-visible damage in
aircraft, missiles and marine
composites led to broad acceptance
of laser based NDT methods.
Laser NDT Methods employing
holography and shearography
imaging interferometers compliment
UT, Thermography and other NDT
methods as highly developed,
mature and cost effective technology.
shearography camera systems,
include a built-in laser illumination
source, the shearing interferometer,
image processing computer and
controls. These systems may
be used
alone with thermal or vibration
stress or
in test chambers with vacuum
shearography techniques.
Laser interferometric imaging
NDT techniques such as holography
and shearography have seen dramatic
performance improvements in the
last decade and wide acceptance
in industry as a means for high-speed,
cost effective inspection and
manufacturing process control.
These performance gains have been
made possible by the development
of the personal computer, high
resolution CCD and digital video
cameras, high performance solid-state
lasers and the development of
phase stepping algorithms. System
output images show qualitatively
pictures of structural features
and surface and subsurface anomalies
as well as quantitative data such
as defect size, area, depth, material
deformation vs. load change and
material properties. Both holography
and shearography have been implemented
in important aerospace programs
providing cost effective, high-speed
defect detection.
images test part responses to
changes in load showing the, as
well as part movement. Holography
using continuous wave lasers and
video frame rate data acquisition
require vibration isolation usually
in the form of air supported isolation
tables. Coupled with ultrasonic
vibration excitation of the test
part, holographic systems in production
provide very high-resolution images
of disbonds in small complex shaped
components, such as turbine aircraft
components and medical devices.
NDT systems use a common path
interferometer to image the first
derivative of the out-of-plane
deformation of the test part surface
in response to a change in load.
This important distinction is
responsible to two key phenomena.
First, shearography is less sensitive
to the image degrading effect
of environmental vibration. Shearography
systems may be built as portable
units or into gantry systems,
similar to UT C-Scan systems,
for scanning large structures.
Second, the changes in the applied
load required to reveal subsurface
anomalies frequently induce gross
deformation or rotation of the
test part. With holography, several
important test part stressing
techniques, such as thermal and
vacuum stress, create gross part
deformation. Defect indications
may be completed obscured by these
translation fringe lines. Shearography,
on the other hand is sensitive
only to the deformation derivatives
and tend to show only the local
deformation on the target surface
due to the presence of a surface
or subsurface flaw.
Shearography, in particular offers
unique and proven defect detection
capabilities in aerospace composites
manufacturing. Shearography images
show changes in surface slope,
in response to a change in applied
load. Shearography whole field,
real-time imaging of the out-of-plane
deformation derivatives is sensitive
to subsurface disbonds, delaminations,
core damage, core splice joint
separations as well as surface
damage. Secondary aircraft structures
have long used composite materials.
The drive for better vehicle performance,
lower fuel consumption and maintainability
are pushing the application of
composites and sandwich designs
for primary structures as well.
Faster and less expensive inspection
tools are necessary to reduce
manufacturing costs and ensure
consistent quality.
Schematic diagram of a
Michelson Type
shearography interferometer
observing a flat metal
plate with a 4-inch diameter
machined flat-bottomed
hole. A center load change
on the plate provides
variable deformation,
observed on the computer
monitor in real-time.
A phase map shearogram
with horizontal shear
vector yields a fringe
pattern showing the first
derivative of the out-of-plane
deformation, ?w/ ?x.
Using an unwrapping algorithm,
the image at right
shows the positive (white)
and negative (black)
slope change. The metal
plate with a 4.0-inch
diameter flat-bottomed
hole was deformed by 7.0
cameras generally use
a Michelson type interferometer
with two essential modifications.
First, one mirror may
be precisely tilted to
induce an offset, or sheared
image, of the test part
with respect to a second
image of the part. The
sheared amount is a vector
with an angle and a displacement
amount. The shear vector,
among other factors, determines
the sensitivity of the
interferometer to surface
displacement derivatives,
Fig 1.
The two laser speckle
images of the test part,
offset by the shear vector,
interfere at every paired
point over the surface
in the field of view.
The single frequency laser
light from the two sheared
images of the part is
focused onto the CCD camera
array of photosensitive
pixels. Light from pairs
of points in each sheared
image interfere. Each
video frame, comprised
of the complex addition
of these two sheared images
can be subtracted from
a stored reference image.
The absolute difference
yields a fringe pattern
observed on the monitor.
The second mirror in the
Michelson interferometer
may be phase stepped using
a piezoelectric device
and the images combined
to create a phase map.
Further processing using
any number of unwrapping
algorithms may be used
to generate fringe free
images of local surface
deformation derivates,
Fig 2.
practice each step in
creating a shearogram
is performed automatically
using image-processing
macros constructed by
combining each processing
function in a sequence.
Shearography system operators
perform a test with a
single keystroke. Portable
shearography systems using
voice recognition commands
have been built further
freeing the operator from
system functional operations.
3 The integrated image of
the shearogram in Fig 2. shows
the out-of-plane deformation.
Integrated images of deformations
derived from shearography
data are free errors due
to gross object deformation
or translation.
Shearography Measurements
calibration of the shearogram
image scale (pixels/inch)
and the shear vector allow
further processing of shearography
data to determine defect indication
dimensions, area and the deformation
of the material. The digital
measurement of the deformation
derivative may be integrated
to show the shape of the target
surface deformation as well
as the magnitude of the deformation
at any location, as in Fig
3. Shearography can be used
to measure the deformation
response of a structure to
an applied load and as a means
for deriving material properties.
Portable Shearography NDT Systems
shearography systems generally
are either tripod mounted or attached
in some manner to the test object
Portable system use laser diodes
and various means such as vacuum
changes, thermal flux or vibration
to stress the object surface to
detect subsurface anomalies.
techniques using portable systems
are excellent for engineered repairs
in composite laminates. Fig. 6
shows a repair to an aircraft
laminate with far side, bonded
stringers (diagonal linear features).
The repair uses scarf plies built
up thicker than the original material;
hence the signal from the stringers
appears to disappear under the
repair. Visible also are areas
of porosity (circled in white).
Test time is 15 seconds.
Portable shearography
systems have seen extensive use
in aerospace and marine composite
inspection since the introduction
of the first systems in 1989.
More than 170 composite boats
and ships, including the Swedish
Visby Naval Corvette ships measuring
73 meters. Portable shearography
systems also recently were used
to inspect the composite wind
fairings covering the full 2,200
ft. length of the Bronx Whitestone.
5. Shearography inspection of
composite honeycomb engine reversers
on the Airbus A330 using the
The structure is GRP face sheets
aluminum core. The inner surfaces
coated with a foam fire retardant
Shearography indications in
the sandwich
structure, through the foam
are routine.
Defects indications are verified
secondary UT measurements requiring
spot removal of the foam.
6 Shearography image of
engineered repair to a solid
aircraft structure with far
side bonded
stringers. Porosity is circled.
mounted shearography cameras,
are used frequently with thermal
stress shearography techniques.
While Thermography is sensitive
to changes in surface temperature
(or the derivatives of the temperature
change), thermal shearography
images changes in the thermal
expansion of a structure. Damage,
disbonds, FOD or delaminations
produce local changes in the coefficient
of thermal expansion.
Thermal shearography is not generally
effected by variations in emissivity
or paint on the test part surface.
7. Thermal shearogram of a Global
Hawk aircraft fairing showing
lay-up of the composite material.
Thermal shearography is used for
detection of disbonds and face
sheet delaminations.
Fixed Production Shearography
First introduced on the USAF B-2
production program, gantry mounted
shearography systems share many
operational features with UT C-scan
systems. These include: teach/learn
part scan programming, electronic
image of the entire part, image
analysis and defect measurement
tools, automated operation. Shearography
system however operate at throughputs
typically in the range of 100
to 500 sq. feet/hour compared
to a typical throughput of 10
sq. ft./ hour for UT C-Scan systems.
In addition, gantries are considerable
less expensive since precision
part contour following is unnecessary.
Currently dozens of these systems
are in operation on aerospace
manufacturing programs
Shearography and holography NDT
methods are mature and cost effective
production NDT methods for many
aerospace applications. Shearography
provides very rapid inspection
allowing immediate feedback for
process controls. Recent inclusion
in ASNT TC-1A will help further
the development of new applications
and methods.


text:
Minneapolis-St. Paul volunteers more than any other city in the country
Minneapolis-St. Paul officially volunteers more than any other city in the country. We should all rejoice in how charitable we are -- or at least, how charitable some of us are, making up for the rest of us who didn't do a damn thing.
Still, 37 percent of Twin Cities residents donated some of their time in 2010, making the metro area tops among all 51 big cities in the country, according to a new study from the Corporation for National and Community Service.
That first place finish puts Minneapolis-St. Paul just ahead of our hipster/bike-friendly rival, Portland, followed by Salt Lake City and Seattle.
Oh, and if you fall on hard times and need a little help, don't expect the terrible people of New York City and Miami to lift a finger for you.
To get the No. 1 spot, the Twin Cities had 917,000 volunteers log about 100 million hours of community service. All those people doing all that stuff is worth about $2.2 billion, according to the study.
There aren't a whole lot of surprises down at the bottom of the list, but it's still nice to find out that all your negative stereotypes about places are confirmed. Among the least charitable cities out of the 51 big ones are San Antonio (which ranked 43rd), Houston (45), Los Angeles (46), and New York City (50) and Miami, which comes in dead last.
Only 15 percent of Miami residents donated time, and those people were probably just helping the homeless work on getting beach-ready abs.
Among big cities, Minneapolis-St. Paul doesn't actually log the most hours of charity per person. That distinction belongs to Salt Lake City, where the average -- the average! -- volunteer hours per year is about 54, or more than one selfless hour a week.
By that same measure, Oklahoma City, Baltimore and Washington, D.C. rank two through four, but it's unclear how much of that is criminals working down their probation hours.
So, there's your challenge, Twin Cities. Lend a hand to those in need, not because you want to do good in the world, but because we need to keep our heel on the throat of Portland's kind-hearted volunteers. Never surrender!


text:
Pancakes are great anytime of the day and anytime of the year!
While this particular plate is a little Fall-ish, that doesn't mean you can't have Butternut Squash Pancakes in December, June, or August!
Butternut squash, protein powder, egg substitute, baking powder, cinnamon, and a splash of vanilla – That's it!!
I use frozen squash puree for three reasons… It's easy! It's cheap! It's available all year!
Feel free to use fresh squash. Just steam and puree it first.
Whether you eat them in a stack…
Or spread on a plate…
Just don't forget the maple syrup!
These low carb, low fat, high protein. gluten free pancakes are a great way to eat your veggies!
Whole Stack – 218 calories
- 1 cup butternut squash puree (I use frozen) (230g)
- 1 scoop Vanilla Whey (30g)
- 1 T egg substitute (15g)
- 1/2 t vanilla
- 1/2 t baking powder
- 1/2 t cinnamon
- sweetener if desired (1-2 packets)
- Cook the frozen squash according to package (I prefer to cook it on the stove top)
- If using fresh squash, just chop it up, steam, and puree
- Mix together all the ingredients
- Cook on medium to low heat
- Use nonstick spray and don't flip too soon!!
- Feel free to use other flavors of protein! Vanilla, caramel, peanut butter, cinnamon...try adding some pecans or walnuts to the batter!


text:
I've now finished the second week of training – it's mighty powerful stuff I'm learning and I'm itching to put it into action but…….the best is yet to come! I haven't even started on the full-blown platform skills yet. THAT is being kept over for the final course starting on the 10th of June. From there it is but a blink before my talks start. I can hardly wait to get going and start to make a change in people's lives.
Month: May 2010
Second course (of the 3 course banquet)
Back in London (or perhaps more accurately, out near Heathrow) – this course is at Twickenham Stadium – the home of English Rugby. There has been a 7s rugby match being played there the past 2 days so it has been quite interesting seeing the locals getting kitted up for a day out in the sun. Unlike soccer, everybody seems to be in high spirits and in the mood for a good time. Lots of amazing dress-ups (and I mean "dress" ups – what is it about British men and cross-dressing?).
The course continues where we left off last week, building on the skills gained there. There seems to be a bit of repetition but this is probably a good thing as it lays down the information more securely. I managed to get a searing headache today but eventually kicked it off, just in time to come home.
Again we have had long days – tonight we finished at 9:20pm – and it is 10:15 before we get back to the hotel. I'm sharing a room with an ex-pat kiwi who has come down from Scotland for the course.
I'm starting to map out the framework for my talks in my mind and the process is interesting to watch (I am able to dissociate myself from the process and this provides an intriguing perspective. If this is the second course and this is happening now, I can't wait for the 3rd course which is the platform skills intensive.
I'm managing to keep in contact with the family via Skype which has been great for tempering my home-sickness. Even so, I am looking forward to getting back home and getting the show on the road.
London calling….
a VERY inspirational day today – I felt like I was being spoken to directly. Yet another sign that I am on the right path & doing what I need to do.
It's past 11pm here after another jam-packed 12 hour day of self-discovery so it's off to bed for me. Time to get my beauty sleep.
'til next time,
…. is finally over – it started at 8am for registration and ended at 9:20pm. This is SOME immersive training – I just hope I can keep my head above water!
We've even got "home-play" to do – a chapter to read and a skill to memorise.
This is heady stuff but it feels right and will provide me with the skills to do what I need to do.
I'm off to do my study, get some shut-eye and get up to do it all again tomorrow.
Cheers for now,
My London odyssey
Just arrived in London and the poms apparently have a new government.
I start my trainings tomorrow morning London time and I'll go exploring this afternoon to make sure I know where I'm going, before getting to bed early. I need to catch up on some zzz before tomorrow – I didn't manage much shut-eye on the plane. 🙁
Cheers for now,
From the bookcase:
Uncertain Science, Uncertain World by geophysicist Dr. Henry Pollack, explains how everyone is born a scientist, with fierce curiosity, instinctive exploration and experimentation being the way children observe and understand the world around them. Then at school, "Science is presented as answers rather than questions," and science becomes boring. If instead we were taught about discovering facts and deriving calculations we would realise how cool it is. Scientists don't help themselves either with a general reluctance to engage in public communication and frequent mistakes by journalists lead to common misconceptions.


text:
Length: 5.6km
Duration: 2 hrs 30 mins
Grade: 4
Style: Return
Start: Galaxia Pl, Kosciuszko National Park
End: Kosciuszko Rd, Kosciuszko National Park
Location: Kosciuszko National Park
Closest Town: Perisher Valley
Distance from CBD: 493 km
State: NSW
Latitude: -36.4108707409
Longitude: 148.4101569715
Keep the Trail Access info current...
Select items to indicate conditions for access to the trail.
2WD Access
4WD Access
Public Transport
Bitumen Road
Gravel Road
Steep Road
Winding Road
Speed Bumps
Vehicle Ford
Entry Fee
Large Car Park
Small Car Park
Accessible Parking
Accessible Toilet
Public Toilets
Drinking Water
Untreated Water
Picnic Shelter
Picnic Table
BBQ Facilities
Campfire Pit
Camping Area
Keep the Trail Features current...
Select items to indicate features found along the trail.
Concrete Path
Timber Boardwalk
Gravel Path
Sandy Trail
Rough Trail
Undefined Trail
Prams & Strollers
Manual Wheelchair
Motorised Wheelchair
Bicycle Trail
Mountain Bike Trail
Historic Rail Trail
Dog Friendly
Urban Walk
Coast & Beach
Historic Lighthouse
Waterfalls & Lakes
Rainforest Walk
Goldfields & Mining
Heritage Walk
Aboriginal Art
Alpine Region
Alpine Huts
Exposed Ledges
Rock Scrambling
Steep Terrain
Bush Bashing
River Crossings
Scenic Viewpoints
Well Marked
Drinking Water
Untreated Water
Fishing Spots
Swimming Spots
Overnight Campsites
Trail Running
Horse Riding
Porcupine Walk is a 5.6km, grade 4 return hike, located in Kosciuszko National Park, New South Wales. The hike should take approximately 2 hrs 30 mins to complete.
Hike Summary
Starting at the Perisher Valley Reservoir this walk heads up through Rock Creek valley to the the panoramic views from Porcupine Rocks. On this walk you will wander through button grass plains and among groves of snow gums whilst passing some granite tors. From the top of this walk there are great views down both Perisher Valley and Thredbo River Valley as well as to Mt Duncan.
Download maps and tracknotes for Porcupine Walk hiking track from wildwalks.com.


text:
Support for Christianity
Chapter 6, Great Gospel of John Book 1
31. 'I myself did not know Him before, but that he might be revealed to Israel I came to baptise with water (the ones waiting for Him)'
1. Naturally, the emissaries thereupon asked John, 'Since when have you known this strange man, and how was what you have just said about him made known to you?' - Here John replied quite naturally that he, as a man, had not known him either, but that his spirit had revealed this to him and induced him to prepare men for This One and to cleanse them with the water of the Jordan of their gross contamination through sins.
32. And John testified further, saying (after the baptism); '(As I baptised Him) I saw the spirit of God (as evidence for me) descending from heaven just like a dove that gently lowers itself, and this spirit stayed above Him.'
2. Here John makes known that he, too, is seeing Me for the first time in person before him, and that My Spirit within him has revealed this to him. Naturally, the emissaries observed this man during the short performance of the baptism with water, which John had initially refused to perform on me with the significant remark that I should baptise him rather than he Me. But when I insisted that it had to be done in this way, John gave in and baptised Me. But he saw what I Myself had revealed to him through My Spirit within his spirit as I had sent him to Bethabara, how the Spirit of God, that is, My very own eternal, primordial Spirit, descended upon Me from the heavens full of light like a shining little cloud in the way a dove descends, and stayed above My head. At the same time he heard the familiar words:
3. 'This is My beloved Son, or this is My light, My own primordial essence in which I, as the eternal, primordial essence of love, am well pleased. Listen to him!'
33. 'I would not have known Him either: but He who sent me to baptise with water, said to me; upon whom you will see the spirit descending, and remaining upon Him, He is the one who will baptise with the holy spirit.'
4. That is why John says, ' I would not have recognised Him either.'
34. 'And I saw it and am now testifying that this is truly the Son of God.'
5. Only after this baptism does John tell the emissaries what he had seen and heard and insist that the Baptised, Whom he had already as He was approaching announced as the revealed Lamb of God, was truly the Messiah for whom all Israel had been waiting. This is truly the Son of God, that it, God's actual primordial fundamental essence within God.
6. He, John, had seen with his own eyes God' Spirit descending upon Him and remaining above Him. Not as if this man had only then received that spirit, but this manifestation took place as evidence for him (John) since he had not known Him before.
7. Here the question arises whether these emissaries from Jerusalem had not perceived these things with their own eyes and ears. The answer to this is always one and the same: These things shall be revealed only to the babes and the simple, but to the worldly wise they will remain hidden and veiled.
8. Thus the emissaries from Jerusalem also saw here nothing but the baptism with water and were quite annoyed when John told them what he had seen and heard. They did not perceive any of this and, therefore, abused John saying that he lied to them. However, several of John's disciples who were present joined them and testified that John had spoken the truth.
9. But the emissaries shook their heads and said, 'John is your master and you are his disciples, wherefore you are confirming his statement. We are learned and wise in all things of prophets and recognise from your words and actions that you and your master are fools, that you do not see and know a thing and with your foolishness drive many people crazy, and that to such an extent that this mater has already for some time been regarded as a nuisance by the high priests of the temple. It would be best to put a stop to your activities by force.'
10. This angered John and he said, 'You snakes, you vipers' brood: Do you think you can thereby escape retribution? Look, the axe with which you would like to destroy us is already laid to your roots; see how you can escape perdition. Unless you repent in sackcloth and ashes and let yourselves be baptised, you will face destruction.
11. For truly, this was the One about Whom I had told you: After me will come the One Who has been before me; for He was there before I was. From His fullness all of us have received grace upon grace.'
12. Following these forceful words, some remain with him and have themselves baptised, but most of them leave greatly enraged.
13. These verses deal with purely historical facts and do not have much inner meaning which can be easily recognised from the previous explanations. Here it must be pointed out that such verses are all the easier to understand if given with the then well-known circumstances. For at the time, the evangelist recorded the Gospel it was customary to omit as unnecessary sentences dealing with all kinds of generally known circumstances and record only the main sentences, leaving all secondary details 'between the lines,' as you would say today. In order to throw more light on this for that time most noteworthy matter, we will have a closer look from this angle at the three following verses and the style of that time will become quite clear and recognisable.
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Cooking class in Marrakech
Transfers Included
Learn how to cook traditional dishes from Morocco and enjoy the meal made with your hands. Book now this unforgettable experience!
You might be interested in...
About this experience
Everybody knows that the best way to get to know and become part of a different culture is by cooking the traditional plates and enjoy the original fresh ingredients on site.
Choice of flavors, spices and vegetables is vital to make a delicious Tagine or couscous. On this half day cooking class, you will get the opportunity to be your own cook! It's time to add Moroccan meals on your menu's list, then enjoying what you made with your own hands!
We will pick you up at your accommodation in Marrakech, to take you to a Riad in the very heart of the old Medina and meet the moroccan cook team that will led you to a unique journey of taste.
After that, you will begin exploring the Moroccan cuisine, and learn how to cook your recipes yourself leaving family and friends shocked by your new knowledge of Morocco cooking traditions.
Experiencing one of the most simple, thus authentic and ordinary activity of Moroccan Culture, will give you the dimension of the real life of the true inhabitants of this place.
Probably you will learn how to create a delicious chicken Tagine with juicy lemons and savoury mediterranean olives, or the world famous cous cous with various tasty vegetables locally known as "the seven vegetables", different typical moroccan salads and delicious dessert made with a variety of succulent fruits.
At the end of this unforgettable voyage into the culinary tradition of Morocco, along with a group of new local friends, you will be get back to your accomodation after the meal made with your own hands. This is surely going to be an experience to remember, and a plus to your culinary skills!
Experience details
How to use the voucher
Mobile Voucher Accepted
Cancellation Policy
Cancel up to 1 day in advance for a full refund
Additional Information
The exact time of pick up and location will be provided the day before the class.
•Have a good time with the team of friendly cook chefs
•Learn how to cook Moroccan style
•Get to know different flavors, spices, and vegetables
•Keep a precious recipe of a Tagine or Couscous in mind
•Enjoy your own-made delicious lunch
•Mix yourself with the local culture
Supported languages
Français, Español, English, عربي
What's included
•Air-conditioned transportation: pick up & drop off at your accommodation
•Cooking lesson
•Accompaniment of cook team
What's not included
•Personal expenses


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Buckshaw Primary School
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The Next 'Bond' Villain May Be 'Wonder Woman' Star Said Taghmaoui
Posted on Tuesday, September 11th, 2018 by Hoai-Tran Bui
Said Taghmaoui could soon make the leap from superhero ally to super-spy villain. The Wonder Woman star has said that he was cast as the Bond 25 villain under Danny Boyle, potentially pitting him against Daniel Craig in the actor's final movie as 007. But with the director leaving the James Bond sequel over creative differences, that role is up in the air.
In an interview with The National, Taghmaoui confirmed that Boyle had cast him as the "lead bad guy" in the next James Bond film. "I was cast by Danny Boyle, and just now he left the project, so of course there's some uncertainty," he said.
Boyle suddenly exited the untitled 007 adventure citing "creative differences" — the catch-all term for behind-the-scenes drama. It's been a month since Boyle left the project and not a peep has been heard from the MGM producers about a new director for Craig's swan song as the British super-spy. And even Craig seems to have gotten sick of waiting around, recently boarding an Agatha Christie-inspired murder mystery set to be directed by Rian Johnson.
Now, Taghmaoui is waiting on a word from producers Michael G. Wilson and Barbara Broccoli, the keepers of the Bond legacy and the deciding factor in the Bond baddie's nationality. The nationality is of utmost important to Taghmaoui's casting, which he's found to be both a blessing and a curse since he first arrived on the scene in 1995's La Haine:
"We don't know who the director will be, and the producers don't know if they're going to go Russian or Middle East with the baddie right now. I literally just received a message saying: 'If they go Middle East, it's you. If they go Russian, it's someone else.' It's the story of my life. Always on that line between something that could change my life and something that disappears."
The French actor of Moroccan descent has found himself typecast as the Middle Eastern villain for so long that he's gotten used to it — though Wonder Woman offered a wonderful reversal, allowing him to play an aspiring actor-turned-soldier. Unfortunately, it sounds like his casting in Bond 25 would have been a return to that niche — though who knows, Bond villains at least get their fair share of scenery-chewing. Taghmaoui acknowledged as much, adding:
"I know that [Bond] could be seen as a big cliche, and I'm always fighting. I refuse so many roles because you fight to get something, you go and audition, and then in the end you have to refuse it because it's just not good. That's how you start your journey."
MGM has set Bond 25 for a tentative November 8, 2019 release, although it is not clear if they will hit that date at this point.


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I have been known to bite the heads off more than a few Movistar employees over the years. In fact, can not really recall ever finding one I did not get in to an argument with. They are well known for their indifferent incompetence. My wife and I recently went in to change phones and plans. She told me from the start to just keep quiet, and she would handle it. Like 5 mins later I was telling her to calm down as she was about to choke the girl on the other side of the counter for just screwing everything up, top to bottom. I kept telling her "calm down, she is just sales person at movistar". Like saying, 'don't blame the mentally retarded child, they can't help it'.Britkid wrote:Movistar is hit and miss quality with almost consistently poor customer service, you pray nothing goes wrong if you are with them.
There was sort of happy ending. After fighting with the desk-jocky that insisted there was no data plan with more data than what we had, turns out for once she was wrong in our favor and the plan I got was actually twice what she insisted did not exist.
Yea, Movistar is one of those companies I just dread anything going wrong that I might actually have to interact with one of their employees.
One tactic that does seem to have a fairly high success rate in dealing with the lazy unhappy desk-jockies in Chile, is to convince them in some way that by helping you out, they are screwing their boss or company over. However much they might dislike you, they definitely dislike their boss more. Become a co-conspirators, even if the results is just the service you should have gotten without resorting psyops to get it done.
My father-in-law was master at it. He would tear down some poor waiter, sales rep, or service guy until they were almost in tears, then build their ego back-up so they thought they were number one in the country. He would walk out with the employee thinking they were best friends, and being told to come straight to them if he ever needed anything in the future. I have never mastered it on the level he did. He was fast and subtle, to the point he could get them there in a few minuets of random conversation. I don't think even if my Spanish was better I could do it the way he did it. I even got a long lecture from one of "his people" 6 months after my father-in-law had died (a door man at his apartment building). They developed this freakishly cult like loyalty to him. Everything the guy said to me, was totally my father-in-law's marching orders down to the words he was using. Even now, if we stumble across anyone that knew my father-in-law (e.g. bank executives, real estate agents, waiters, maestros, etc.), problems just magically get solved.


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He is eager to follow in the trail of close friends Anirban Lahiri and Arjun Atwal.
Shubhankar Sharma is all set for his maiden World Golf Championships-Mexico Championship appearance next month and the rising Indian star intends to keep his career trending upwards with hopes of reaching the ultimate destination, the PGA Tour, very soon.
His stunning rise, which has been predicted by some of India's leading golfers, was capped by a brilliant final round of 10-under 62 in Kuala Lumpur which shot him to the top of the Race to Dubai rankings and Habitat for Humanity standings on both Tours respectively.
"I'm really excited as it was a goal of mine to get into one WGC event this year. I knew I had to be in top-10 in Europe to get it done. I'm really happy how things have changed for me. I can't wait to play against the world's best in Mexico," said Sharma.
He is eager to follow in the trail of close friends Anirban Lahiri and Arjun Atwal. The former is a two-time Presidents Cup star and a regular on the PGA Tour while latter is India's first winner on the world's premier circuit.
"The goal is to win the bigger tournaments and to play on the higher tours.
"That's what I'm looking at and I'm very focused about it. Playing on the PGA Tour has always been my dream. It wasn't long ago that I would watch PGA Tour Live with my friends, spending some late nights watching the World Golf Championships and the big events in America," he said.
Sharma ended last season at no. 202 in the Official World Golf Ranking but success in Malaysia has pushed him up to 72nd, making him the highest ranked Indian currently on the planet.
Now that he's in the WGC-Mexico Championship from March 1 to 4, the young man also hopes to qualify for the WGC-Dell Technologies Match Play in Austin later in March which the top-64 golfers in the world as of March 12 will be exempt.
Then, the next goal will be to break into the top-50 which can potentially reward him with invites to the Masters Tournament in April and The Players Championship, which is the PGA Tour's flagship tournament, in May.
"If I can get into the top-50, I'll get some opportunities in America and I will cherish those opportunities.
"Things are moving too fast for me, and I am just trying to stay confident and keep playing well. I received a call from Anirban after Malaysia and he's encouraging me to keep going as I could get into some really big events. It's still some way to go but I'll try to ride on the momentum," he said.
Golf fans beyond Asia would not have heard of Sharma's name until his most recent success. As a kid, he was encouraged to learn the game through the influence of Lahiri's father, who served in the Indian Army alongside his father, Col. Mohan Sharma.
After developing into a leading amateur where he won the all-India amateur title at the age of 16, Sharma turned professional.
"My dad is a great visionary and he saw my potential. I wasn't convinced of turning pro at that age and others told me to wait as well.
"Then one day, dad sat me down for one hour and said we have to get to somewhere in life. It was my dad's decision which I followed his advice. Everything's fallen into place thanks to him," said Sharma.
Many of his peers have marveled at how Sharma thrives under pressure and keeps a level head which he attributed to meditation taught by his mother, Neena. "It really helps when I am in a tough spot, especially when I am not playing well. I try to control my breathing and stay in the moment as much as possible," he explained.
"We're a religious family and mum taught us to meditate by sitting down cross legged, doing some breathing exercises and just trying to clear your mind. It's been a routine of ours since we were kids."
He plans to stick to his winning recipe, which includes working continuously with long-time swing coach Jesse Grewal and Gurbaaz Maan, who tends to his club-fitting needs. And of course, his parents and younger sister are always providing the morale support.
"Golf is a process. You put in the hard work and there is a time that everything bears fruit. You have to wait for the right moment. I won't say I'm surprised (with the wins). When I turned pro, I always thought of achieving a certain level and knew there would be a day I would break into the world's top 100.
"Every golfer dreams of becoming the world no. 1 and that motivates me as well. Going to the golf course and getting into the big events, you keep setting new standards. I'm sure Dustin (Johnson) isn't content at being world no. 1 and he wants to win more majors. I want to be world no. 1 too one day, win the World Golf Championships events, win the majors and play on the PGA Tour. Getting a chance to play at that level will be incredible."


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Sepsis is the clinical syndrome of a systemic response to microbial infections. During septic shock, mortality can peak at 56% [1,2]. Sepsis is associated with altered micro-hemodynamics and heterogeneous local perfusion, micro-thrombosis and endothelial dysfunction, alteration of permeability, and interstitial fluid shift [3-6]. The endothelial glycocalyx is a complex macromolecular network involved in many endothelial functions [7]. Sepsis leads to ubiquitous degradation of the glycocalyx, altered endothelial permeability with hypovolemia, hypoalbuminemia, and edema [8,9]. This review focuses on the role of glycocalyx during sepsis.
Structure of endothelial barrier
Endothelial cells line in a single layer along the inner portion of the heart, blood vessels, and lymphatic vessels. They derive from angioblasts and hemangioblasts and thus are sensitive to the mediators of angiogenesis such as vascular endothelial growth factor (VEGF) [10]. The space between two contiguous endothelial cells is called the endothelial cleft (ETC), which acts as an important site of regulation of endothelial permeability (that is, paracellular permeability) [11]. The apical side of endothelial cells is layered by the glycocalyx, which is 1 to 3 μm in depth (Figure 1). Synthesis of glycocalyx is complex, involving multiple enzymatic pathways; factors regulating its shedding include local pH and mechanical stimuli [12]. Components of glycocalyx include cell-bound proteoglycans, glycosaminoglycan (GAG) side chains, and sialoproteins [4,8,13]. Proteoglycans consist of a core protein to which GAGs are linked. Core proteins include syndecans, glypicans, and perlecans. This complex network envelops endothelial cells on their luminal side and inside the clefts, where it continues into the extracellular matrix of the basal membrane. Soluble components - that is, albumin, unbound hyaluronic acid molecules, thrombomodulin, and various serum proteins (for example, superoxide dismutase, antithrombin III, and cell adhesion molecules) - are bound to the luminal portions of glycocalyx [4].
Main methods for studying/visualizing glycocalyx
Owing to its fragility and instability, endothelial glycocalyx has been particularly difficult to characterize and understand in its three-dimensional structure [14]. Transmission electron microscopy (TEM), the original method of visualization, has several technical limits and a great deal of effort has been made to reduce them [12,15,16], such as substituting the original ruthenium red staining with Lanthanum or Alcian blue, which allow a better preservation of glycocalyx. The use of non-aqueous vehicles of perfusion is also associated with better preserved samples. Finally, by observing the glycocalyx on rapidly frozen tissues, the alterations due to organic solvents are avoided. A major limit of TEM is that it cannot be used in vivo. Another method for direct visualization of glycocalyx is based on fluorescent-labeled 'lectins', which are proteins that specifically bind to some components of glycocalyx, or on fluorescent-labeled antibodies for heparan sulfate, syndecans, or hyaluronan. A semi-quantitative measurement of fluorescence can be obtained with a confocal laser scanning microscope in small vessels, whereas in larger vessels two-photon laser scanning microscopy is used because of its increased depth of penetration into tissue [17].
Among indirect methods, intravital microscopy or intravascular volume determinations with permeable/impermeable tracers have been used [18,19].
Physiologic role of glycocalyx
The glycocalyx plays a key role in microvascular and endothelial physiology, in particular by regulating microvascular tone and endothelial permeability, maintaining an oncotic gradient across the endothelial barrier, regulating adhesion/migration of leukocytes, and inhibiting intravascular thrombosis [20,21]. The glycocalyx acts as a 'mechanotransducer', transmitting shear stress forces to endothelial cells through its intracellular protein domains. Conformational changes in glycocalyx structure lead to release of nitric oxide, thus contributing to regulation of vasomotor tone and peripheral distribution of blood flow/oxygen to tissues [15]. Acting through this mechanism, the glycocalyx contributes to regulation of local blood flow of organs and acts as an effector of metabolic coupling between organ function and local hemodynamics. The glycocalyx is central in maintaining the oncotic gradient across the endothelial barrier. In the so-called 'paracellular permeability model', fluids and solutes flow from the intravascular to the interstitial space through the glycocalyx that surrounds the ETCs and reaches the basal membrane. Therefore, the oncotic gradient between intravascular and interstitial spaces is set between the plasma and the glycocalyx rather than being trans-endothelial. In physiologic conditions, the glycocalyx retains a high reflection capability for albumin because of the high density of negative electric charges of its GAG side chains [22]; thus, albumin is not allowed to flow through the clefts (Figure 2). About 40% of total human body albumin is intravascular, whereas only 5% is normally allowed to flow in the interstitial space. Thus, albumin is the main determinant of intravascular colloid-oncotic pressure (πiv). In the paracellular permeability model, the ETCs act as the small pores of the capillaries, through which the transcapillary flow of fluid occurs. In the traditional Starling model, the driving forces for this flow are the intracapillar hydrostatic pressure (Piv) and the interstitial colloid-oncotic pressure (πis). Since the inner portion of the ETCs is covered by the glycocalyx, it was recently proposed that the sub-glycocalyx colloid-oncotic pressure plays a major role as a determinant of transcapillary flow [20]. In normal conditions, this 'sub-glycocalyx' space is virtually protein-free, and the only determinant of the transcapillary flow is the Piv. The πiv opposes the flux but does not reverse filtration through the endothelial barrier. In normal conditions, only small amounts of fluid are filtered and most of it returns to the circulation via the lymphatic system. In clinical conditions of increased capillary porosity, like sepsis, albumin and other proteins may reach the extravascular space and, consequently, πis rises and the flow of fluid increases. The use of colloids for volume resuscitation has been associated with increased need for renal replacement therapy, worsening edema, and mortality [23]. This could be due to progressive accumulation of colloidal molecules in the interstitial space through the injured endothelium. In this scenario, functional integrity of the lymphatic system is essential to avoid edema formation [20]. Furthermore, since πiv opposes the fluid transcapillary flux but is not able to reverse it, infusion of albumin or synthetic colloids would not reverse the process of edema formation. This explains why albumin infusion, despite showing a better 'volemic' effect, is not able to resolve the interstitial edema in patients with sepsis [20,24]. In hypovolemic states, the fall in Piv leads to a transient back-filtration of fluid from the interstitial space in the intravascular space; as a result, Piv progressively increases until filtration stops. In sepsis, inflammatory injury to the glycocalyx increases porosity of endothelium, and albumin can flow through the ETCs; πiv increases and this further opposes back-filtration of fluid and drives edema formation [20]. Infusion of colloids or crystalloid to restore macro-hemodynamics leads to a progressive increase in Piv that further contributes to trans-capillary fluid escape and interstitial edema. Therefore, the smallest possible volume for plasma volume resuscitation should be used in order to maintain normovolemia and simultaneously reduce the risk of accumulation of interstitial fluid. In sepsis, where porosity increases because of inflammation injury, colloid molecules can flow in the interstitial space, thus increasing πis. These observations may have clinical consequences. Indeed, an interesting recent study on murine models by Bark and colleagues [25] showed that, in conditions of increased transcapillary flow like sepsis, the total volume of colloids necessary to maintain normovolemia can be significantly reduced when administered in slow infusion rather than as a bolus. This effect is probably linked to a sharper increase in Piv that follows quick administration, which in turn leads to greater transcapillary flow.
Molecules of heparan sulfate link antithrombin III, preventing microvascular thrombosis and contributing to maintain microvascular patency. Moreover, the negative charges of GAG side chains inhibit endothelial adhesion of platelets and red cells, further contributing to maintain microvascular anticoagulant properties and rheology. The glycocalyx inhibits leukocyte adhesion to endothelium, thus preventing migration of neutrophils in non-inflamed tissues [7,26,27]. Indeed, integral glycocalyx has a geometry that prevents the interaction between circulating leukocytes and adhesion molecules or selectins. In case of shedding, exposure of these molecules occurs, with subsequent endothelial-cellular interaction [15]. Heparan sulfate binds endothelial superoxide dismutase and xanthine oxidoreductase [28-32]. Thus, intact glycocalyx protects endothelial cells from oxidative stress [20,21].
Glycocalyx during inflammation
Localized or systemic inflammation leads to changes in structure and physiology of glycocalyx, inducing endothelial dysfunction (Figure 3). First and foremost, inflammation injury to glycocalyx is linked to increased paracellular permeability and outflow of albumin/fluid in the interstitial space through the ETCs [20]. Loss of anionic charges, changes in geometry of the clefts, and direct endothelial injury are responsible for this. Other observed changes in glycocalyx function during inflammation include loss of vascular tone with local blood pooling, degradation of heparan sulfate leading to a shift toward a pro-coagulant state with consequent micro-thrombosis, enhanced expression of adhesion molecules with increased leukocyte trafficking, and loss of antioxidative properties with progressive oxidative injury to the endothelium [15]. From an evolutionary and adaptive perspective, this local inflammatory response represents an active and structured response to tissue invasion by micro-organisms or unrecognized cells. In clinical syndromes of systemic inflammation, such as sepsis, major surgery, trauma, ischemia/reperfusion, and prolonged hyperglycemia, diffused and persistent alterations of glycocalyx are linked to widespread endothelial dysfunction, altered permeability, and impaired oxygen and nutrient delivery to cells [8,33,34]. There is experimental evidence that thickness and stiffness of endothelial glycocalyx are reduced by lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF-α) exposure [35]. Clinically, these alterations are linked to loss of vascular tone, loss of albumin, hypovolemia, edema formation, and organ dysfunction [7]. Persistence of these alterations is associated with poor clinical outcome even if macrohemodynamic derangements have been corrected (see below). Furthermore, owing to the ubiquitous nature of the glycocalyx, its alterations lead to clinically relevant effects of inflammation also distant from primarily involved organs (that is, 'organ cross-talk' as in acute cardiorenal syndromes, where inflammatory injury to kidneys leads to inflammatory damage to endothelium) [36,37].
Exposure to pro-inflammatory mediators such as interleukin 1 (IL-1), IL-2, IL-6, TNF-α, and other molecules released during acute inflammation such as bradykinin, thrombin, VEGF, and histamine results in endothelial activation and massive increase in glycocalyx expression of endothelial leukocyte adhesion molecule 1, intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1). These proteins promote leukocyte rolling, adherence, and migration, which initiate the inflammatory damage to endothelium and tissues [10]. Subsequent damage to endothelium promotes degradation and shedding of glycocalyx with progressive increase in paracellular permeability. During this shedding process, adhesion molecules are released and can be found in circulating blood; thus, in patients with sepsis, circulating levels of VCAM-1 and ICAM-1 parallel those of IL-6 [38]; this was more evident in patients with hyperglycemic sepsis, in which the inflammatory damage to endothelium may be worsened by persistent hyperglycemia [39]. In an experimental model of sepsis, high levels of TNF-α were associated with reduced expression of syndecan 1 and altered composition of hyaluronan and sialic acids [40]. Shedding of the glycocalyx and release of syndecans in the circulation may also retain an adaptive function in limiting the inflammatory damage mediated by TNF-α. Interaction of syndecans with TNF-α leads to a structural rearrangement of endothelial cells and loosening of intercellular junctions; this greatly increases paracellular permeability, further allowing extravasations of fluids, albumin, and solutes [2]. It is known that VEGF induces angiogenesis and markedly increases endothelial permeability [41]. Gram-negative bacterial LPS increases VEGF-mRNA expression in macrophages and induces release of VEGF by leukocytes and platelets [42]. The kidneys are a major source of VEGF production in humans, and it has been speculated that VEGF may play some role in regulating the glomerular permeability to protein. The mechanisms of increased vascular permeability by VEGF may involve stimulation of collagenase production and proteolytic disruption of the endothelial basement membrane [6,43]. Renal release of VEGF during septic acute kidney injury may contribute to distal organ endothelial damage (that is, organ 'cross-talk'). Therefore, it is important to underline that the urinary microalbuminuria has been demonstrated to be a reliable marker of sepsis-induced alterations of endothelial barrier and changes in systemic paracellular permeability [9,44-48]. Indeed, albuminuria greatly increased in an experimental model of sepsis in association with the aforementioned observed structural changes of glycocalyx [40].
Oxidative stress plays a central role in inflammatory injury to glycocalyx. In vitro, exposure of GAGs to reactive oxygen species derived from leukocytes (such as superoxide anion and hydroxyl radicals) causes fragmentation of GAGs with loss of some of its components [49]. Degradation of glycocalyx will expose the endothelial cells to oxidative damage, which has been linked to increased porosity, and interstitial loss of albumin observed in both severe sepsis and chronic conditions like diabetes or hypertension [21,34].
In patients with sepsis, endothelial glycocalyx may be affected by co-existing clinical conditions. Lipoprotein-lipase controls the release of fatty acids to tissues and its primary site of action is the luminal side of the endothelial cell (glycocalyx) [21]; diet-induced hyperlipidemia produces a significant endothelial injury, resulting in transfer of proteins in the sub-endothelial space [50]. Pro-inflammatory cytokines locally released by perivascular adipocytes act through a paracrine mechanism and independently contribute to glycocalyx injury [51]. In contrast, glycocalyx integrity may be protective in atherosclerosis [52], whereas in patients with heterozygous familial hypercholesterolemia, the overall volume of glycocalyx is decreased [53]. Both acute hyperglycemia and chronic hyperglycemia induce shedding of the glycocalyx, contributing to endothelia dysfunction and loss of albumin [54]. It was found that, compared with healthy individuals, patients with diabetes mellitus type 1 or type 2 have a reduced volume of glycocalyx [55]. It is reasonable to argue that acute systemic inflammation observed in sepsis may act in combination with chronic hyperglycemia, insulin resistance, oxidative stress, or activation of the renin-angiotensin system to amplify the already existing injury to glycocalyx. This could make it difficult to compare septic patients with different co-morbidities. The extent of this phenomenon is still unclear, and disease-specific markers of glycocalyx injury have not been described.
Markers of glycocalyx degradation
Circulating levels of syndecan 1 are related to endothelial damage and glycocalyx degradation and correlate with serum levels of inflammatory cytokines [56]. They are also associated with coagulopathy and increased mortality in trauma patients [57]. Since levels of syndecans may be higher in patients with sepsis than in surgical patients, they are thought to be a biomarker of more extensive damage of the glycocalyx since they are core proteins [38,58]. Endocan is another component of glycocalyx that can be released in response to TNF-α and IL-1 and act as a biomarker in patients with sepsis. Circulating levels of endocan have been shown to correlate with severity of sepsis [4,59], and high serum levels of endocan were associated with the development of acute lung injury after major trauma [60]. As such, endocan is considered a promising biomarker of endothelial dysfuncion in sepsis.
The increase of microalbuminuria is a consequence of increased permeability due to inflammatory injury to glomerular endothelium which is frequently observed in clinical practice and experimental models of septic-related acute kidney injury (see above) [43]. In individual patients, the microalbuminuria-urinary creatinine ratio (MACR) correlates with severity scores such as the Surgical Stress Score [61], the Injury Severity Score [62], Acute Physiological and Chronic Health Evaluation II [63], the Sequential Organ Function Assessment [64], and the Simplified Acute Physiology Score II, and with duration of mechanical ventilation and partial pressure arterial oxygen/fraction of inspired oxygen ratio [65]. In patients with sepsis, MACR levels increase earlier than C-reactive protein and procalcitonin [66]. Indeed, microalbuminuria itself may be considered a marker of sepsis severity [44].
Angiopoietins (Angs) are a novel class of angiogenetic growth factors that have recently been recognized to play a substantial role in the inflammatory process [67]. Ang-1 promotes structural stability of blood vessels, whereas Ang-2 promotes vascular destabilization and permeability [67]. Ang-1 and -2 are reciprocally antagonistic factors involved in important intracellular pathways. In critically ill patients, the release of Ang-2 directly reflects vascular barrier breakdown [68]. It has been demonstrated that Ang-2 is increased in septic shock and that its increase is related to unfavorable outcome [69], although routine measurement of circulating Ang-2 is not clinically feasible.
Therapeutic strategies
Despite the growing evidence that glycocalyx is extensively involved in sepsis-related altered vascular permeability, strategies aiming at correcting these alterations failed to show clear clinical benefit [3]. Corticosteroids could decrease the inflammatory injury in systemic sepsis and reduce inflammatory damage to endothelium [48]. Indeed, there is some evidence that their use is associated with reduced microalbuminuria; a protective effect on glomerular glycocalyx may be postulated [6,44]. Indeed, low-dose hydrocortisone improved MACR in patients with severe sepsis [44]. Corticosteroids are known to inhibit cytokine synthesis, in particular TNF-α. Since TNF-α leads to rearrangements of endothelial cells (see above), reduced release of TNF-α could preserve the integrity of the endothelium [6]. Despite this experimental evidence, the clinical utility of corticosteroids in sepsis is still debated [70,71]. Anticoagulant molecules such as antithrombin or activated protein C may exert their effects by preserving glycocalyx integrity [72]. However, both molecules failed to improve outcome of patients with septic shock [7]. The use of antioxidant therapies may help to preserve integrity of glycocalyx. One study showed the efficacy of an infusion of N-acetylcysteine in preventing hyperglycemia-induced shedding of glycocalyx [73]. This supports the role of oxidative stress in the impairment of the glycocalyx and in endothelial dysfunction. However, definitive evidence of clinical utility of antioxidant in sepsis is still lacking. Tight glycemic control may reduce glycocalyx shedding in sepsis and preserve endothelial function [21,73]. This potential positive effect of glycemic control has been confirmed also for chronic hyperglycemia [39,74].
Endothelial dysfunction and glycocalyx degradation are key features of sepsis. In severe sepsis and septic shock, they cause alterations of macro- and micro-circulation, alter organ perfusion, and contribute to cellular hypoxia, which all lead to organ dysfunction. Inflammatory-mediated endothelial injury can be responsible for a number of specific clinical effects of sepsis, including acute kidney injury, respiratory failure, and hepatic dysfunction. Markers of glycocalyx degradation, such as microalbuminuria or circulating levels of endocan or selectins, are promisingly employed as markers of severity of sepsis. Some of the proposed therapies of sepsis, including corticosteroids, may counteract alterations of endothelium and glycocalyx. Their actual clinical efficacy still needs to be proven.


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"Trying to Save a Year by the Already Approved Verdict by ACADEMIC COUNCIL 2016, Yet Not Applied by BANGALORE UNIVERSITY Shows the Negligence Towards Students" sign now
The present rules that Bangalore University follow regarding the examination patterns for Undergraduate and Postgraduate are: Odd semester's (1,3 & 5) exams that take place in the month of November & December and even semester's (2,4 & 6) exams that take place in the month of May & June. It is mandatory for a student to have 75% of attendance in each subject to write any paper. The largest concern faced here is students in the first semester have two opportunities to appear for a re-examination in the third and fifth semesters. Those in the second semester also get two opportunities in the third and fifth semesters. Students studying in the third and fourth semesters have one chance each at a re-examination in the fifth and sixth semester, respectively. There was, however, no provision for students of the fifth and sixth semester to take the re-examination without losing a year.
'Undergraduate students at Bangalore University, who fail their fifth semester examination, will no longer have to wait an entire year to take a re-examination. They can now appear for the re-exam in the sixth semester itself, starting this year. This decision was approved in the Academic Council meeting on 29 Tuesday 2016. "Speaking to Deccan Herald after the meeting, university's Registrar (Examinations) K N Ningegowda said, "This is a historic decision and will prevent an entire year getting wasted. Students would otherwise have to wait for the whole year and during this time, they may not be able to get employment or pursue higher studies."
Even though the rule was approved long back yet BANGALORE UNIVERSITY has taken no interest to apply and follow them. The intension of making rule of saving a year has lost its essence after approval by not making a change in the current academic system. Re-Examination pattern should be started for fifth and sixth semester in order to facilitate employment or pursue higher studies. "We want Bangalore University to take an immediate action on already approved decision from the Academic Council,2016. We want to see its impact in 2018 for Even semester itself."
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Welcome to Fades Barbershop
We at Fades Barbershop are ranked among the busiest barber shop throughout the Boiling Springs/Spartanburg area. We are fully dedicated to making sure you are satisfied. We focus on quality and not quantity, that is why we dedicate time to each hair service we perform. We want to leave you with an excellent impression of our talents.
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- 更新時間:2019/03/18 14:55:17
In order to encourage their people to start their own businesses, activate the traditional wisdom of Indigenous Peoples, and promote industrial development, the Council of Indigenous Peoples would continue to promote the 5th Lean Startup Counseling Program in 2019. The regional proposal presentation meetings were held from October to November in 2018, attracting more than 500 people to attend and learn about the content and proposing method. A total of 124 business program proposals had been received. After qualification, written and first-stage briefing review, 28 entrepreneurship teams with innovative ideas and development potential were selected in today's announcement. The proposed program covered agricultural marketing, professional sports training, outdoor experience education, tribal in-depth tour, clothing design, weaving culture industry, tuning and acoustic engineering, etc. The entrepreneurial types were very diverse.
According to the Council, the professional consultant team would provide guidance, consultation and discussion for the teams that have passed the first stage of the briefing review, so as to help the teams find their core values and fulfill the products, services and cost actuarial analysis. The Council also took training courses and assisted the teams to systematically and logically draw and program the business blueprint for the next 1 to 3 years. Besides, each team that passed this stage would also receive a bonus of NT$ 20,000, which could be used to make product prototypes or establish business models. After the first stage of business model validation, each team would enter the second stage of briefing review, and up to 20 teams would be selected as the final winners, providing up to NT$ 1 million for the first barrel of money for startup. The Council also provided six months of guidance for entrepreneurs to innovate their business models, improve their knowledge of operation and financial management, and enhance their industrial competitiveness.
The Council further stated that, since 2015, it had coached 80 enterprises, created more than 400 opportunities and an output value of NT$ 300 million. In order to continue to support the development of economic and industrial development of the Indigenous Peoples, the Council would continue to promote various programs of economic and industrial development, as a favorable backing for the development of the cause of their people.
Business Undertaker: Sha, Yun-Wen 02-89953212


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As mentioned by one of the principals at the Epic Build Showcases perhaps the most impressive thing about these projects is that while they all have similar themes they are all incredibly different as well. Similar to Borland Manor, South Central and Wylandville second graders also learned about Pennsylvania history with their showcases. But because there is so much about Pennsylvania history that students can learn every project had different features that their robot went to.
Another example of how different similar themes can be are the third grade classes at South Central and Wylandville. For one third grade class at Wylandville for example each group in the class researched a different continent. They learned things like different types of land for example and then made their own versions of it for their robot to travel to. They then each presented what they learned to their parents.
While all projects are impressive, perhaps the most impressive is that for the first time at all of the schools kindergarten classes took part in the Epic Build Showcases. For the first project kindergarten classes built houses with logos and they learned about styles of building like stacking versus overlapping. They then coded the house they built with sentences about themselves. They also did a second project where they coded their name. South Central kindergartner Ellie showed off how she was able to change the color of her name, change the background and move the letters around.
Keep an eye out for invitations to the third round of Epic Build Showcases for each school, which will be in May. The rest of the elementary schools second round of Epic Build Showcases are as follows:
Feel free to tag us in any photos that are posted in any social media posts using the hashtag #codetothefuture!
Click here to stop by our Facebook page for more fantastic photos from all of the Epic Build Second Round Showcases!


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When you have Numerology 9 Love Life, you are creative, compassionate, and giving. In the bedroom, the Life Path 9 is incredibly romantic.
You'll do anything within your power to be known as Princess or Prince Charming. Your goal is to surprise your partner with pure pleasure.
Are you on the path to ultimate life success?
Why leave it to chance? I highly recommend that you take this 60 second quiz and then check out your customized report that comes from it.
==> 60 Second Life Success Quiz (and personalized report)Enjoy and go well!
Sometimes mysterious and charismatic, you're more than open to various sexual techniques. You enjoy using sex toys, going to a nude beach, or watching erotic videos with your partner.
You want to know correctly what your partner wants, and enjoy and you come out and ask.
You're a giver and will postpone your satisfaction for your partner's benefit; ultimately you make sure your needs are met.
The opposition: This life path is learning how to give and receive. Often the 9 can encourage or enable negative or self-destructive behavior in a relationship. This is producing tense or toxic sexual dynamics.
Learn How will be my love life according to numerology?
Always remember that your Life Path number 9 doesn't solely define your sex style—your personality profile consists of several other numerological influences. It is always beneficial to dig a little deeper and learn how you engage with all the numbers represented in your chart. To discover what numerology says about your love life and to understand your sexual love style, get your free customized numerology reading.
Numerology 1 Love Life, Numerology 2 Love Life, Numerology 3 Love Life, Numerology 4 Love Life, Numerology 5 Love Life, Numerology 6 Love Life, Numerology 7 Love Life, Numerology 8 Love Life, Numerology 9 Love Life, Life Path Number 22
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Allow Master Numerologist to decipher the meaning behind your unique number >>>
My path began in 2010, and I follow an eclectic, solitary path. My blog is for anyone interested in Pagan beliefs, Wicca and Witchcraft, or Numerology. My goal is to share my expertise in this path with anyone curious in reading about them and give you access to valuable and accurate information.
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Stratasys introduced another market-disruptive 3D printer, the J750. The new solution breaks restrictive technology barriers, enabling customers for the first time to mix-and-match full color gradients alongside an unprecedented range of materials to achieve one-stop realism without post-processing.
The Stratasys J750 allows customers to choose from more than 360,000 different color shades plus multiple material properties - ranging from rigid to flexible and opaque to transparent. Prototypes can include a vast array of colors, materials and material properties in the same part, speeding production of realistic models, prototypes and parts for virtually any application.
The J750 enables near instantaneous decision-making by streamlining the way products are designed, evaluated and brought to market. The productivity-boosting J750 is expected to improve TCO (Total Cost of Ownership) by eliminating many of the traditional complex processes, time and resources required to create product-matching prototypes. Designers and engineers can physically experience true product prototypes within hours of developing an initial concept for immediate design and function validation with internal stakeholders and end users.
The J750's one-stop realism is supported with a streamlined workflow beginning with the all new PolyJet Studio™. The software's new intuitive user interface allows users to simply choose materials, optimize the build and manage print queues. Assignment of colors, transparencies and rigidity is eased via familiar design controls. Color textures can be loaded fully intact via VRML files imported from CAD tools.
The Stratasys J750 also minimizes downtime associated with material changeovers. Featuring a large, six-material capacity, it keeps the most used resins loaded and ready for printing. Newly designed, state-of-the-art print heads means simulated production plastics, like Digital ABS™, can be 3D printed in half the time of other Stratasys PolyJet systems. As 3D printed models are delivered complete with full colors, color textures and multiple materials, no time is wasted on painting and assembly.
"With the introduction of the J750, we are harnessing more than 25 years of experience to set a new historical milestone in 3D printing - reaffirming our commitment to keeping customers always on the cutting edge of innovation," said Josh Claman, Chief Business Officer, Stratasys. "With its one-stop realism, the J750 is quite simply a game changer. By combining full color with multiple materials and a streamlined workflow, it recalibrates the impact of 3D printing in the product development cycle. Informed design decisions can be made immediately after the concepting stage. The time saved by eliminating the painting and assembly process can lead to faster product delivery times. The J750 is a multi-purpose system that can also produce production tools, manufacturing moulds, teaching aids, and other models - truly raising the bar in 3D printing versatility."
Among the many organizations and businesses that can benefit from the J750 are consumer product companies, service bureaus, design firms, education, universities and research institutions, medical device companies, hospitals, medical schools, and special effects and animation companies.
Customers can order the Stratasys J750 immediately. Delivery times may vary according to region.
The Stratasys J750 is being showcased at AMUG 2016 this week in the Demo Suite.
For more information, visit: www.stratasys.com/j750


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After Arsenal's 3-1 win over Western Sydney Wanderers in Australia on Saturday, Arsene Wenger spoke of his conviction that Oxlade-Chamberlain will stay with the Gunners.
The most recent and reliable report concerning Liverpool's interest in Oxlade-Chamberlain is from Sky Sports who indicate that the Englishman is "increasingly likely" to leave Arsenal this summer.
With a new contract with the North London club yet to be signed, it looks as though Chamberlain's future does lie elsewhere and whether he'll move this summer or next is up for debate.
Unless you're Arsene Wenger. In that case, you're adamant that your no.15 will stay at the club.
Wenger had this to say about Chamberlain not leaving this summer, "Yes. 100%, I expect him to stay. No matter the speculation, he will stay."
If you're someone who is desperate to see Alex Oxlade-Chamberlain sign for Liverpool, don't worry too much about what Wenger will have to say in press conferences.
He's always going to speak diplomatically in public. What's the alternative? Publicly condemn the player and confirm that Chamberlain is on his way out because he won't sign a new deal? That would never be the case and certainly never with a manager like Wenger who is very good at working the press.
Wenger has been in the business long enough to know that he can't reveal that Chamberlain is on his way out.
With most reports indicating that Chamberlain is unwilling to commit to Arsenal and looking for more game time and a new challenge, it's likely that he will join Liverpool this summer with the prospect of Champions League football under Jürgen Klopp an exciting prospect.
Liverpool are heading off to Hong Kong for the Premier League Asia Trophy this week and Sadio Mané will likely join his teammates despite midweek reports to the contrary.
Andy Robertson is close to joining the Reds after Liverpool opened advanced talks with Hull City for the Scottish international while Naby Keïta will be the subject of a £65 million bid this week.


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The Asus RT-AC66U router is dual-band router which is offering 802.11ac Wi-Fi, combining 2.4GHz/5GHz bands for a 1.75Gbps bandwidth. Its USB integration allows it to act as a multitasking device with server capabilities. By accessing the Asus RT-AC66U setup or quick internet setup page, you can configure the various features of this router. Keep going through the entire blog to know the process for Asus RT-AC66U login and setup.
How to access the Asus router?
- Make sure all the cables attached to the Asus RT-AC66U router are plugged in and firmly inserted.
- You need to ensure that your router is powered on and connected to the PC either wired or wirelessly. If your PC connects to the router using a cable, Router's web login page automatically opens when you launch your web browser.
- If your PC connects to the router wirelessly, then you have to select the network first.
Follow the steps to login to the Asus web interface:
- This router has a web interface for configuration. In order to log into the Asus RT-AC66U, you can use any web browser.
- Enter the web address router.asus.com or http://router.asus.com in the address bar of the browser. In case, you cannot access the Asus router using web address, use the default IP address i.e. 192.168.1.1 to access the Asus router login page.
- Further, Asus router sign in window displays in front of you. Enter the default username and password then click 'Login'.
- You have now entered into the setup page of the router. You will see some instructions on the screen to setup the router if you are setting it up for the first time. But if you have already done the setup and want to change the settings then you can do it by browsing different sections of the menu.
- If you want to get the complete steps for Asus RT-AC66U login and setup then you can contact our technical experts at our toll-free no. For live interaction, you can also opt for live chat support window.
Let's have a look at some more impressive features of the Asus RT-AC66U:
- 3 potent external antennas
- 2 integrated USB 2.0 ports.
- Wireless transmission speeds of up to (450 +1450) Mbps.
- Its external antennas provide one of the most consistent signals for downloading, streaming video, as well as everyday surfing use.
- 4 Gigabit Ethernet ports.
- Asus RT-AC66U is secured with SPI and NAT firewalls that protect your network devices from web-based attacks.
- WPA2 encryption is used to secure your wireless signals that prevent unauthorized access to home network.
We hope this article will help you out to setup your Asus router. For any query, please contact us at our toll free no. or chat live with us.


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Could the new fiduciary rule effectively enhance portfolio performance for retirement savers?
A change is coming. The Department of Labor is introducing a new rule regarding retirement accounts – a rule that is profoundly impacting the financial services industry. The rule will require financial services professionals to serve as fiduciaries when they provide advice about IRAs or workplace retirement plans.1,2