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This application note evaluates the performance of a UPLC oa-ToF MS system for the high throughput QC screening of pharmaceutical-like synthetic compounds. The overall result is a UPLC oa-ToF MS system providing a very powerful analytical platform for high throughput screening applications.
Generic or standard chromatographic methods in combination with orthogonal acceleration time-of-flight (oa-ToF) mass spectrometry have become critical tools for use in high-throughput QC screening of synthetic medicinal compounds. Short analysis times are often employed due to the high sample numbers required for fast lead discovery strategies. Over recent years, the combination of LC and ToF MS has proven to be a suitable analytical technique to address these needs. Furthermore, the technique provides mass accuracy within 5 ppm of the actual value which is required for journal publication, patent submission and accurate structural identification via elemental composition calculations.
The use of more conventional techniques such as NMR cannot address these high throughput analytical needs due to relatively poor sensitivity, high sample purity requirement, necessity of operator expertise and the use of costly solvents. To simplify and streamline the analytical procedures, automation in combination with open access is a key factor for this type of application.
A fast, generic liquid chromatographic method at high pH has been designed to provide excellent selectivity for the investigation of basic compounds without compromise of either chromatographic resolution or speed of analysis. To obtain such an analytical method, Ultra Performance LC (UPLC) in conjunction with oa-ToF MS detection has been employed. With this analytical system, identification of the anticipated samples, isomers and possible impurities with mass accuracy deviations less than 5ppm from the actual were obtained using LockSprayTM. With such high accuracy data, the calculation of elemental compositions for each of the analytes was possible. Subsequent elemental composition results were produced using MassLynx i-FIT algorithm which takes into account the distribution of the spectral isotopes for the compounds of interest, and employs novel data interpretation to simplify results lists returned. To simplify and speed-up the processing of the sample batch, OpenLynx Application Manager was also utilized for fully automated QC of the compounds analyzed. Results were calculated for sample purity by UV, exact mass and elemental composition
All samples were analyzed using a Waters Micromass LCT Premier mass spectrometer equipped with a dual electrospray (ESI) LockSpray ion source. Leucine Enkephalin was used as the reference mass compound during all ESI-MS exact mass experiments and introduced via the LockSpray channel using a Waters Reagent Manager. The ToF analyzer was calibrated with cluster ions of sodium formate. Data were acquired in positive ESI at spectral resolution of >10,000 FWHM with the extended dynamic range functionality provided by the LCT Premier instrument.
The mass spectrometer was connected to a Waters ACQUITY UPLC system with PDA detection. Highest separation efficiency is normally obtained at optimum HETP, which is at a higher linear velocity for 1.7 µm UPLC particles compared to more conventional 3 µm HPLC stationary column packing. The gradient was therefore scaled in proportion to the flow and gradient of a traditional HPLC separation of basic synthetic medicinal compounds, which was from 5 to 85% B in 2.35 min at 0.4 mL/min. The injection to injection cycle time was 3.75 min. Mobile phase A comprised 395 mg/L NH4HCO3 + 250 µL NH4OH 30% and mobile phase B was CH3CN/mobile phase A (90/10, v/v) The column used during this study was a BEH 2.1 x 50 mm, 1.7 µm column, maintained at 55 °C.
All samples were obtained as solids or oils in 2 mL vials containing approximately 0.3 mg of sample and reconstituted with 1.5 mL of CH3CN/H2O (75/25, v/v). The sample solutions were vortexed for 20 seconds until a clear solution was obtained. The samples were diluted a further 10-fold with CH3CN/H2O (75/25, v/v) prior to LC-PDA-MS analysis.
The first example is shown in Figure 1a, illustrating the PDA total absorbance chromatogram in the top trace and the base peak intensity chromatogram in the lower trace. The exact mass and elemental composition of the peak eluting at 1.37 was determined by means of manually processing of the data. The elemental composition report is given in Figure 1b.
Based on mass accuracy only, C18H21NO3Cl3 (-0.2 ppm) would have been the most likely elemental composition for this compound. However, as the isotopic distribution of the acquired spectrum closely matches the theoretical distribution of C17H15N5O3SCl (0.5 ppm) the latter correct composition was assigned. This resulted in better ranking by i-FIT, which is shown by the higher probability - expressed as lower value - in the elemental composition table. Also shown in the chromatogram is an isomeric form of the main compound eluting at 1.69 min. With such a short gradient run-time, this level of chromatographic resolution is only obtainable through the use of UPLC.
Another example is shown in Figures 2a and 2b. The displayed information and algorithms used are similar as shown for the previous example. The elemental composition algorithm would have assigned C13H33N4OS4 (1.3 ppm) as the correction composition. However, the i-FIT algorithm ranked C20H25N2O4S (1.8 ppm) higher based on the observed 32S and 34S isotopic distribution. Also note the high quality of the chromatographic separation shown by the base line separation of a small impurity eluting at 1.34 min.
The OpenLynx application manager was used to QC a set of 21 real samples and 5 QC controls. The assay was setup with QC checks based on sample "QC5" (C20H24N2O4S, [M+H]+ = 389.1535). The QC checks were conducted every fifth injection to facilitate full control and verification of the total LC-MS system stability and robustness. An example of the OpenLynx browser output is shown in Figures 3a and 3b. Figure 3a shows the identification view with details on the exact measurement and i-FIT elemental composition conformation. The top left Pane - confirmation view – shows the autosampler bed layout with the identified samples in green.
In this example, two isobaric compounds were positively identified eluting at 1.47 and 1.53 min, respectively. Figure 3b shows the purity view with QC selection based on UV purity. The top left pane shows the autosampler bed layout again with the pure sample labeled in green (purity greater > 80%). Blue labeled spots are tentative identifications (60% < purity greater <80%) and red ones are failed samples.
In order to assess the performance of the OpenLynx application manager for exact mass measurement determination, all samples analyzed were processed manually. Table 1 provides a comprehensive overview of all the exact mass data obtained for all samples. As can be seen from the results, both data sets are consistent and the average mass errors for all 26 runs are well below 3 ppm providing high levels of accuracy and thus a high degree of confidence in the data.
The aim of this application note was to evaluate the performance of a UPLC oa-ToF MS system for the high throughput QC screening of 'pharmaceutical-like' synthetic compounds. The introduction of UPLC as a separation technique provides analysts with the ability to drive analytical runtimes down without any compromise in chromatographic resolution that would have normally been seen with HPLC. The use of high performance oa-ToF mass spectrometers with enhanced spectral resolution allows exact mass measurements to be generated easily over wide dynamic ranges, providing highly specific answers. Having the ability to generate an exact mass measurement routinely provides the capability of determining elemental compositions and in return a high level of confidence in the data produced. The overall result is a UPLC oa-ToF MS system which provides the analyst with a very powerful analytical platform for high throughput screening applications.
UCB Pharma, Braine-l'Alleud, Belgium (www.ucbpharma.com) is kindly acknowledged for manufacturing and providing the synthetic medicinal compounds.
720001435, January 2006


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please contact our support team.
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If you want to find out more about Actionstep call 800 257 4042 or fill out the form below.
For product support, please contact our friendly support team.

subset: commoncrawl


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Think about the industry that you are in. There are probably many businesses who are offering similar services or products as you. In the commonplace market these other businesses are considered competitors. More than likely you have many competitors in your space. This is completely normal, unless you are in a very different line of business. One thing I am personally learning is that what we can generically see as competition, can actually become a partnership of sorts. This can happen in several different ways.
- If there is a company that offers similar services as you, they may only really be able to handle more wealthily clients. Big branding companies can charge thousands of dollars a month to their clients where you may only charge hundreds. For that bigger company, they can offer much more to their clients than you can because of the size of their team. You could always talk to the leader of that company and see if they would be willing to direct clients with a smaller budget to you and you will return the favor by pointing clients who need more than you can currently offer back to them. Quid Pro Quo.
- Many times it is helpful if different companies specialize in certain areas. Say you have two media companies. Both may dabble in music production, engineering, and video production. If the two find a way to narrow their individual focus to a specific area, they could master that particular area more and share clients. Most of the clients really need all those services combined and so you can work with the same client for different services. This also gains the clients trust. Companies who are after the money will often offer to do anything for it. Those who care about the outcome of the client, will try to make sure they get the best service provided. Having a partnership with someone else in that field allows for that to be accomplished.
- Another possibility is to create an affiliate programs. This is similar to the previous idea. Only this would provide incentives for your partners to send business your way. When they send you business, you send them a portion of the income from that business transaction. This works really well for many companies and small business owners.
- After working with a partner like this, one day you may actually combine forces full-time. This would be considered a joint venture where a new company is established and all the services and products are provided in that new company. This is usually a harder thing to accomplish, so it doesn't happen too often. It can be hard to figure out the leadership dynamic and overall company structure in these scenarios. This usually turns into an acquisition instead of a joint venture. Make sure to get some experienced third-party help if you plan on creating a joint venture.
These are just a few ways to convert a competition into a partnership. There are others creative ways to do this as well. You really need to get to know others in your industry and make sure you don't burn any bridges. Business isn't about tearing down everyone else so that you can succeed. It is about being the best at what you do and serving the customers. That can often include pointing them to another business that can better fit their current needs. This shows that it isn't all about you, but about the customer. It is a narrow path and that is why very few take it. Stand out and be smart and considerate.
Thanks for reading this weeks Business with Bordeaux blog. For all of my blog postings and podcast episodes you can visit businesswithbordeaux.com.
Thanks and God Bless0


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What is planet X also known as Planet 7X or Nibiru and what does it mean for us on earth? Is there a biblical connection and does it play a roll in the end-times?
There is evidence of an ongoing resurgence of the Planet X (also known as Nibiru) cataclysm conspiracy theory following the publication of new scientific studies in 2014 claiming evidence of a mysterious unnamed planet lurking beyond Pluto. The scientific claims were based on observations of gravitational influences on a group of space bodies termed the "extreme trans-Neptunian objects" (ETNOs) orbiting our Sun beyond the planet Neptune.
A slew of messages and YouTube videos currently being circulated in the conspiracy theory blogosphere claims that a NASA study published in 1988 revealed details about the mysterious Planet X/Nibiru with an estimated orbital period of more than 1,000 years.
The study, according to conspiracy theorists, demonstrates that NASA and the U.S. government have been aware for decades that the rogue Planet X is coming with catastrophic consequences for humanity.
According to conspiracy theorists, recently leaked secret NASA "Planet X" files reveal that the agency is aware that the gravitational influence of Planet X had disrupted the orbits of other planets during a previous passage into the inner solar system hundreds of years ago; and that the next disruptive passage into the inner solar system is imminent.
Watch the Video:


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Baby Face
BabyFace Portraits For Children Under 5
We are getting ready to launch our fresh new style of child portraiture called 'Baby Face' and have 10 pre-launch sessions to give away which will include an 8 inch framed desk portrait.This style is contemporary in look with close cropped head and shoulder shots,in a modern square format. We are also commissioning an exclusive range of products which will include special discounts for all those who book a Baby face photography experience with us.
To apply, your child must be between 6 months and 5 years of age and available for mini session during the week.
Please note that you will be asked for a refundable booking fee of £20 to confirm your booking, this is to ensure you arrive for the session slot and not waste our studio giveaway. This will be returned to you at the viewing & ordering appointment.
Terms and Conditions
- The Baby Face will take place in our Fairford studio
- The viewing session will take place at our Fairford studio and must be attended to claim your complimentary gift
- A £20 refundable booking fee will be requested when booking in order not to waste any of these time slots. This will be returned to you at the viewing or can be used against any orders places as well.
- No purchase necessary
- Experience must be booked online from the dates available


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State with this Region
Other Regions
Montgomery, AL Car Donation Information
Support a local charity in Montgomery through a simple and hassle-free vehicle donation. Enjoy free pick-up, tax deduction – and a charity in Montgomery receives the support they need to continue their important work in your community.
Donate cars, trucks, vans, RVs, boats, motorcycles, and other vehicles and provide a nonprofit working in your community the support they need to achieve their mission. We proudly serve the greater Montgomery area, including Hope Hull, Prattville, Wetumpka, Tallassee, Tuskegee and Montgomery County.
The mission of the American Diabetes Association is to prevent and cure diabetes and to improve the lives of all people affected by diabetes.
Suggested Charities
Home for Little Wanderers
Children, Human ServicesDonate a car
Barrett Foundation
Children, Human ServicesDonate a car
National Alliance on Mental Illness California
Children, Human ServicesDonate a car


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Framing Gift Certificate
Available Qty:
This certificate entitles the bearer to One Hundred Dollars worth of picture framing including molding, glass, matting, mounting and labor at McCool's of Bon Air for the period of one year after the date below.
This certificate is good for picture framing only. This certificate can not be redeemed for cash. Should the order leave value remaining on the certificate, that value can be used on a later order.
Expires 1 year after issue date.
Listed in:
- Art/ Antiques and Collectables: Framing - Art
- Art/ Antiques and Collectables: Art & Pictures
- Art/ Antiques and Collectables: Portraits
- Personal Services and Grooming: Wedding Services
- Personal Services and Grooming: Weddings
- General Merchandise for Sale: Gift Certificates


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What do you're keen on most about travel? Holidays are supposed to be fun and gratifying and this is one more reason for traveling abroad in the present day. The traveling couple dated long-distance for a whole yr, and during that point, the 2 of them went on their own separate adventures. This is a crucial motive for traveling internationally now since you may get essentially the most out of your trip.
BestReviews is a product evaluation company with a singular mission: to assist simplify your purchasing decisions and save you money and time. If traveling internationally, make sure your paperwork are in order. It does not take a lot effort to sign up for hotel or airline frequent traveler programs, or to make use of a basic travel rewards bank card for the spending you were going to do anyway.
My most up-to-date favourite book for that sort of "travel with out travel" is Adventures of a World-Traveling Scientist by Stanley Randolf. Nonetheless, let us get right down to the more practical causes for traveling internationally. Every trip gives you linked experiences from actual individuals to be able to get a greater image of the place you wish to go.
When people decide to go away the comforts of their house and venture to different locations there's often a reason behind it. Whether the cause to travel was a last minute whimsy or had an actual objective, it makes one think about all the the explanation why people travel. Companies that enable you within the actual "planning" phase of your trip, would be like Gap Travel Adventures, Get A , the Automobile Club of Southern California Travels Division (and their counterparts in each of the 50 States), and the American Categorical Company, whereas the giant travel conglomerates, such as Expedia, Travelocity , and Priceline (the 4 largest travel distributors in "gross income" inside the United States), intention at the end reserving course of.
We also provide you with tips about planning quick trips and last-minute travel. Once you begin experiencing the beauty of the world, chances are you'll even begin planning yearly worldwide vacations. The University Ethics and Compliance Office is producing a collection of 5-minute animated movies on vital compliance topics for employees traveling internationally.
What do you like most about travel? As human beings, we've got the choice to extend our aptitude within the artwork of appreciating magnificence by opening ourselves to it and making ourselves accessible to experience it. Travel and exploring the world supplies us with that opportunity in spades.
The atmosphere and journey of another time and place can work its magic to make me really feel I've left my own residence and flown off to some nice new expertise. Travel with us on a trip to trip spots within the United States of America – to study the alternative ways of the American citizen.
If peer opinions are more vital than procuring by charges, than web sites like Trip and a few of the top ranked travel blogs, like with Finances Travel and Travel all have stellar reputations for providing unbiased opinions. In the event you're traveling with a toddler, a bag that keeps all the things accessible is a must.
Within the spirit of spontaneity, Topdeck is searching for true thrillseekers, however you may must show it. You have till Might 31, 2019, to submit your most spontaneous travel story to Topdeck through Fb Messenger for your likelihood at this shock trip of a lifetime.
When folks decide to depart the comforts of their home and venture to other places there is normally a purpose behind it. Whether the trigger to travel was a last minute whimsy or had an precise objective, it makes one take into consideration all the explanation why folks travel. Twenty-four years in the past, I knew so little about travel rewards that I took an round-the-world trip with out signing up for a single frequent traveler program. Though it's possible you'll be weary about paying $25 for a straw, you should keep in mind that it can actually last you a lifetime — and save the world a lifetime of waste.
The most important fast financial savings in planning your journey could be to use an internet travel web site to research, plan and guide your travel adventures vs. going to a neighborhood travel agent the place you live. An experience she doesn't recommend is getting caught on a visit with a wrinkly outfit — particularly when you're documenting your expertise by means of quite a few pictures and videos.
Totally different Means Of Travel!
However, in some instances, this can be beneficial for travel, the airlines could lower their prices as a way to get your small business and this may save you cash.
International travel is usually a great experience; it lets you witness many new cultures and lifestyles. Nonetheless, in some instances, this may be beneficial for travel, the airlines may lower their costs in an effort to get your business and this will prevent money. For couples planning a vacation, a Travel 2.0 website provides them the opportunity to see and examine places other travelers have been to and suggest.
The financial system appears to be in dangerous shape and many people are trying to save cash. The Cabeau Evolution pillow is created from premium memory foam and the removable, delicate velour cowl is straightforward to clean, so you possibly can travel with a contemporary, germ-free pillow each time you hit the road.
Holidays are meant to be fun and fulfilling and this is one more reason for traveling overseas right this moment. The traveling couple dated lengthy-distance for a whole year, and during that time, the two of them went on their very own separate adventures. This is a crucial purpose for traveling internationally now since you will get probably the most out of your journey.
BestReviews is a product evaluate company with a singular mission: to assist simplify your buying selections and prevent time and money. If traveling internationally, be sure that your documents are in order. It does not take a lot effort to sign up for lodge or airline frequent traveler programs, or to use a normal travel rewards bank card for the spending you were going to do anyway.
Travel Information, Guides, Images And Movies
What do you're keen on most about travel? They include Eire's Wild Atlantic Approach , a 13-day trip starting in Shannon and concluding in Dublin; Jewels of Eire , a complete experience inside the country's vibrant culture and history with stops in Dublin, Blarney Castle, Dingle, the Cliffs of Moher, Killarney Nationwide Park and Galway before shifting on to Slieve League Cliffs, Belfast and Big's Causeway; and Style of Italy , a seven-day culinary journey of Venice, Florence and Rome.
In 2011, Lauren Juliff quit her job, bought all the pieces she owned, and started traveling the world. Money is necessary in case you are planning to travel and see the sights the nation has to supply. Now, the editors are making that luxurious life-style a actuality for one lucky individual with the ultimate summer job: You may fly around the globe reviewing flights, lodges, trains and more for TPG's international audience.
Virus! Treatment Viruses, Greatest Free Anti
When folks resolve to depart the comforts of their residence and venture to different areas there is often a reason behind it. Whether the cause to travel was a final minute whimsy or had an precise function, it makes one take into consideration all of the the explanation why folks travel. I travel continuously and always to vastly completely different locations, but if there is a theme to my finest journeys it's all the time in regards to the people I meet, those that've thrown out the rule e-book and are living life on their own phrases, whether or not it's a salmon fisherman in Ketchikan or the lady I met within the Prepare dinner Islands running a stand-up paddleboarding business.
As human beings, we've the choice to increase our aptitude in the artwork of appreciating magnificence by opening ourselves to it and making ourselves out there to experience it. Travel and exploring the world offers us with that opportunity in spades.
travelers insurance phone number, travelers insurance company, travel agency miami
What do you like most about travel? The season for summer travel is nearly upon us, so now's the time to top off on necessities to take the hassle out of planning your journey. Begin planning your journey trip now. It will keep your toes flat to negate any decrease again ache or leg swelling that you would usually experience, and it's easy to chuck into whatever bag is closest to you.


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NPCBL Job Circular 2018 has been published a new Government Jobs vacancy noticed. They will take some new employees in this bd job circular. We also published this Government bd Job News in job360news.com. Most of Bangladeshi people are looking for a Government Jobs. Because, Government Jobs is popular and interesting job in our country. So, we think that NPCBL Job Circular 2018 is very important who are looking for a Government jobs at this time. Below are all shortly information given in this bd Job News.
In short of NPCBL Job Circular 2018:-
Name of Organization: Nuclear Power Plant Company Bangladesh NPCBL
Application Release Date: 08.10.2018
Education qualification: See circular below
Job Type: Government Job
Source: Online
Location: Bangladesh
Salary: 48,000 – 62,400 TK
Job Nature: Full Time
Apply Process: Interested Candidates have To Apply Through Online at npcbl.teletalk.com.bd. Online Apply Start 03 October 2018 and Last Date 18 October 2018 at 11.59 PM. After Complete Online Application Then Pay Fee by Send SMS From Teletalk prepaid Mobile. Online Apply Ins.
Application Last Date: 18.10.2018
For more information see below original circular.
NPCBL Job Circular 2018
There are various facilities in Government job which is improve the quality of your life. They also provide weakly holidays, monthly amazing salary, salary increasing system year by year, and many more. Google is currently the most searched for Government jobs. If you want to apply for NPCBL Job Circular 2018, you have to visit their official website. All are Interested and eligible people can apply NPCBL Job Circular 2018.
bd job circular
Bangladesh is a small country. But her people more than area. Moreover, There are many unemployment people looking bd Job News in Bangladesh. We shared this bd job circular description of all bd Job News necessary information. If you want to get more information about different types of bd job circular such as Bank Job, Marketing Job, Pharma Job, Industry Job, Private Job, NGO Development Job, Company Job, Accounting Job, IT Job, Medical Job, stay and connect with us on our official Facebook page. Don't forget to share Facebook, twitter, google plus, and also other social media. Thank you for visit my website.


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Make Toothbrushing Fun for Your Child
Getting your children to brush their teeth can be a lot like, well, pulling teeth, and it is a challenge many parents list among their greatest difficulties. But getting children to brush—and do it correctly—may require a change of perspective. Dentists have spent decades helping children view taking care of their teeth not as a chore to be dreaded but as a game to be enjoyed. Here are a few of their techniques you might want to try with your children.
Musical molars: Brushing the teeth requires a certain amount of time. Most electronic toothbrushes have built-in timers to make sure that at least two minutes are spent brushing teeth. But what if, instead of counting up to two minutes, you used music to pass the time? Pick a favorite children's song at least two minutes long. Challenge your child to thoroughly brush each tooth before the song ends. If he or she manages to brush every tooth with time left, challenge the child to brush each tooth twice! Remember to monitor the toothbrushing. They cannot win the game if they don't brush each tooth thoroughly or if they neglect their gum lines!
Harry Potter and the Plaque of Peril: Why not take advantage of your child's love of make-believe? Turn toothbrushing time into a story featuring their favorite characters. Perhaps you could say that Lord Voldemort (of Harry Potter fame) put plaque on the teeth to help the Death Eaters control your child's mind and that he or she must brush that plaque away before it becomes dangerous. For children who are easily scared, use a less-threatening villain.
ChoreMonster: An app for iOS, Android and Windows smartphones and tablets called "ChoreMonster" creates a reward structure for children who complete their chores. You set a schedule for how often a task needs to be completed, and assign from 5 to 5,000 points for completing it. When a certain point level is reached, the child can choose an appropriate reward that you have created. Many parents find that using the app helps motivate their offspring to become more disciplined about their personal responsibilities. Why not add toothbrushing to the to-do list?
Seasoned parents know that the best way to turn a child off from toothbrushing is to make it a struggle. We have many other easy tips and tricks to get children to brush their teeth in our oral care toolbox. Let us know if you need additional suggestions at your child's next visit to KiDDS Dental.
Click here to schedule an appointment with Dr. Jared. Or give us a call at (509)-891-7070.


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GarminSaturday, January 30th, 2010
In a previous post I commented about some problems with Garmin RoadTrip under Snow Leopard. It doesn't appear to be quite as I implied. I did another test and found that waypoints did get transferred although I'm fairly certain that there was nothing different from the previous experiment. I'm going to leave updating my laptop for a few more weeks in any case.
Had an interesting exercise this afternoon. I needed to get some additional maps for my Garmin and so visited the Garmin site and identified what would be suitable, and purchased it as a download. The plan was to put a new empty microSD card into the eTrex and download the map to that. However, the first hurdle was that the Garmin software indicated that the firmware in my device needed updating.
I launched the Garmin WebUpdater for mac and indeed it showed that I was considerably behind in firmware updates and so I took a deep breath and started the process. It informed me it was "erasing…" and not to disconnect and continued to say that for some time. After 20 minutes or so it was clear that it wasn't working but it wasn't obvious how I could stop it or whether my GPS would now be bricked. The GPS showed some text implying it was loading but that also was unchanged for many minutes. I held the on/off button to turn the device off, unplugged it and turned it on, half expecting to find that nothing would happen. Fortunately it did start as normal.
I ended up doing this a second time with precisely the same problem.
Looking on the Garmin website there is a small note part way down the page saying that if the update hangs in the "Erasing" phase to try plugging the device directly into the computer. Like many people I have a number of USB devices and so typically I plug in via a hub. I think one of the most annoying aspects of USB is that unpredictable problems sometimes arise from hubs. Anyway, plugging the device directly, the update went smoothly in probably just a minute or so.
I was then able to get back to downloading the new map. This was not a particularly large one (only a few hundred megabytes, not like some that are a gigabyte or more), but obviously this took a while. Again an annoyance was that it said I was overwriting an existing file when the microSD card was empty. However, having got the confidence to ignore this, it all seemed to work fine.
Overall, I'm glad I'm able to do this from my Mac as previous DVD map purchases have required the use of a PC, but it isn't quite all smooth sailing yet.


text: The way in which MSH exerts its dispersing influence on the melanin granules in the melanocytes of amphibians has been the subject of many investigations. Different aspects of the dipersion process have been discussed by a number of investigators. The facts point to a rather complicated series of reactions, ... read more


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"Penguin Zen"
22 hours ago
She couldn't say :Why don't ya take a picture, they last longer!".....because you already were! Lol!
This is such a great painting!
In fact, all the paintings here are winners!
If she had said anything, I wouldn't have understood her anyway. The look however, said it all...ha1 Thanks for the very generous comments Dean.Delete
wonderful! i love the shadows! beautifully done vern!ReplyDelete
Thanks Suzanne, it's always great to hear from you.Delete
A fantastic composition - great to see your work.ReplyDelete
Good to hear from you again liz...thanks.Delete


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Mr. Shorey, also from the Clams, had gone into hiding in a town about thirty miles away, but the engineer would patch him into the studio via telephone. He would sit in his living room and rave while we attempted to provide a musical backdrop. We did several of these shows. However, the last one was a call-in format, in which the listening audience could call and talk to us. We'd planted some shills who would call in with incomprehensible music theory questions for which we already had the answers. These calls would be interspersed with taped "musical" interludes from previous shows to demonstrate the ludicrous answers. Unfortunately, someone called in who was extremely despondent and contemplating suicide. Markham tried to convince this kid that, yes indeed, suicide was his only option, and aggressively tried to encourage him to do it while we were on the air. It was an actual crisis call and we were never invited back to the station again. There were also some minor misunderstandings with the FCC regarding profanity. We made another tape or two, one being recorded in a railroad boxcar.
Markham then went off with a road band called "James Blond" and I went off with another road band, both being booked by Ms. Bednar and her evil co-agent we called the Gimpy Gnome.
After a particularly grueling tour of five states and 31 nights playing without a single day off, I went to the Air Force recruiter, became a navigator, and flew B-52's for Ronald Reagan for a number of years. Once, when we were doing an airborne exercise in which air defense controllers were trying to vector fighters in on us, I put Grackle music out over the radio for communications jamming. Worked pretty well. In 1986 I received the Cosmic Sassy Grackles tape in the mail but I'm not sure who was on it. One time when I was home on leave I met Markham and Bert in a room filled with synthesizers and we made another tape.
After getting out of the service; being gone eight years; and being in town only twenty four hours; Markham and Bert tracked me down and advised me that the Grackles were the opening act at a show at the Kimo theatre downtown the next night. I approached this with some trepidation, knowing that we never had any real songs, really hadn't seen each other in many years, and we certainly didn't have any songs in common now. However, I agreed to play. In those days computers were not commonplace, but Bert had cleverly programmed all of his drum sounds into a little keyboard, and ran it into a Pignose amp with about a two-inch speaker. The sound guys put a big mike in front of it and ran it into a huge stack of amps. Markham had a keyboard, an open tuned electric guitar, and two stacks of Marshalls behind him.
I did a solo album in the early 1990' s. My last gig was last summer at a Czechoslovakian wedding in which all of the attendees wound up in a drunken, slobbering, spastic stupor, unable to speak or see. The Grackles could have played there and no one would have known the difference.
Jeff Smith
Tijeras, New Mexico


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Noob and Pro went a long way to find mysterious golden apples, but Hacker steals them!
You have to get them back! But how? Ask God about it! Help him and he will help you!
– Story mode – single player
– PvP mode for 2 players on one device – play with friends
– A lot of genres in one game
– Interesting story with Noob in the lead role
– Funny humour and jokes
– Fight zombies, drive car, kill boss and destroy Hacker!
You will play as Pro and Noob.
It's a great adventure – time to try it is now! 🙂
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Game is absolutely free and has no in-app purchases.
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In Southern California, the partial solar eclipse at 7:47 pm can't be seen, but it sure will be felt! Are you ready? Combined with a New Moon in the sign of Cancer, with an opposition to retrograde Pluto, and blessed with a grand earth trine, this New Moon is poised dispense a dose of good cop/bad cop, astrologically speaking.
The bad news, other than the New Moon's nickname of "Hades Moon", is that the Solar Eclipse falls in the decan that contains the twin stars of Castor and Pollux. This translates to volatile moods, extreme passion, and bi-polar energies that make it hard to make a decision. A Solar Eclipse can bring an awakening or a shocking revelation that upsets you. Castor is known for prominence in occult matters, government work in foreign affairs, serious accidents, blows, stabs, shooting, evil disposition, rape, murder committed or suffered, imprisonment, banishment, and decapitation. Wow! With the Eclipse's proximity to these stars, and the fact that it's in opposition to retrograde Pluto, it's a wonder we don't just skip July altogether, right?
Retrograde Pluto is kind of a dark horse because it represents a time of reflection about power and control in your life. Are you being manipulated or abused in some way, or are you trying to control someone? If the former, now is the time to make a stand up for your rights. Let go of the people who are controlling you (read on for more encouraging advice). If you're the controller, it's time you let go of that behavior. Surrender your power and control to a higher force, and trust your instincts and spirit guides.
It'll be very interesting to see how these darker forces of this lunation affect what's happening in our country's already bi-polar political scene, and on the world stage. Just know that there's another aspect to the New Moon/Solar Eclipse today - we have two lovely Grand Trines to help save us all!
A Grand Trine is a planetary pattern composed of three or more planets in a chart located at the vertices of an imaginary equilateral triangle. Usually all three planets are in the same element, and this time we've actually got two - one dominated by water signs involving the Sun and Neptune, and a Grand Earth Trine, involving Venus, Saturn and Uranus. This is auspicious, because although you may feel like you're drowning in watery feelings and emotions, it can provide stable yet flexible containment that helps you shape your watery energy into something constructive, productive or useful. This is the time to transform whatever's holding you back from happiness and success. Hard work and determination will unleash the potential held with the Grand Trines to help prevent a personal crises.
Pictured above is our altar in the store, decorated with items helpful for this New Moon/Solar Eclipse. You may notice, elevated in the center of the floral wreath, an antique carved soapstone horse, which is a nod to this Moon's affinity to horses. Surrounding the wreath are crystals of Moonstone, Labradorite, Mookaite Jasper, Citrine, Selenite, Sunstone, and Smokey Quartz. We also have locally sourced altar salts from Violet Maven, a red candle from Coventry Candles, a bottle of Divine Protection essential oil blend, and a Sage & Lavender smudge stick from Wolf Spirit. All these items are available in store, along with other various sage combinations, Palo Santo, incense, and essential oils.
Our best advice to getting through this tumultuous New Moon and Solar Eclipse is use this period to break any bad habitual behavior and use it as a cosmic "reboot". Until the Full Moon, blessed be!
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What is this discrepancy? The Journal of Pediatrics published a report that only 18% of pediatricians reported having formal training in sleep disorders, but 96% felt it was their job to treat them. Their conclusion is that training programs should provide sleep education.
While on the surface this sounds like a great idea, reflecting back on my training and early years in practice, residency would have to be extended by many years to teach all that I need to know at my job. Teaching sleep hygiene (or not teaching it) is just the tip of the iceberg. Not to mention that there is new information all the time about how to do things better, so the learning should really never end.
I learned about car seats after my son was born during the end of my 3rd year of residency.
How did I make it 3 years without learning about car seats??? I would simply mention to parents to be sure to use one. If they had specific questions about if the baby was properly in the seat, I referred them to a car seat expert. (We refer to a lot of experts in residency.)
We took my son home from the hospital on an icy February day in a warm jacket buckled into the car seat. When we got home and I went to unlatch the buckle I realized it had never clicked. The jacket was too bulky!!! We went to a car seat check a couple weeks later and his car seat wasn't even tight enough ~ this is before the LATCH system helped secure the seat. My own baby had been unsafe. How awful is that after nearly 3 years of pediatric residency? Of course now, 12 years later, many car seat rules/recommendations have changed. Gotta keep learning!
I had a little formal education about breastfeeding, but it was mostly the technical aspects of how milk is produced, not how to help a mother/baby be successful with breastfeeding. That I learned when struggling to breastfeed my first baby, and along the way with other moms and their various problems. My second came along and breastfeeding went great, but she wouldn't take a bottle. Boy, did I learn a lot from my own kids with two very different feeding problems.
I don't remember a single lecture on nutrition, though I'm sure we had them. Not much on exercise that I recall. These would have been considered "easy" topics and as a resident we were more focused on studying acid base disorders and intricate diseases because that would be what we would be tested on. I wish I learned more about nutrition and exercise psychology because of the current level of obesity, but it is a relatively new problem in pediatrics -- one even the specialists aren't sure how to manage.
It is estimated that 40% of primary care visits involve behavior problems, yet I only had a single one month rotation on psychiatry. I am still learning new tricks 12+ years into practice. Many of my experiences as a parent color what I have learned in this arena. I also have the privileged position to learn from the families I see at work. All of this information I use to counsel families about these issues. I could never have learned this in a lecture, or even in a clinic with a preceptor for a one month rotation.
Simple things, like what to do with a baby who has a nose filled with mucus, were not discussed in lectures because there were more advanced things to learn, like how to manage a child on a ventilator. I don't ever manage ventilator's now, but I had to learn how in residency. Why learn that? Because it teaches doctors to think.
We need to learn the basics in school about how the body works. The psychology, pharmacology, physiology, and all the other -ologies.
Residency teaches us how to apply these things to the human person. Treating the sickest of the sick in the hospital setting teaches us to recognize sick and become independent learners.
Starting up in practice teaches us more about common illnesses and concerns. We sharpen the skills of disease management and normal growth and development with all of its variances from following the same kids over years. We must incorporate everything we know from books, lectures, clinical experiences, personal experiences, and more into caring for our patients with the most current evidence based and practical methods available.
Starting up in practice teaches us more about common illnesses and concerns. We sharpen the skills of disease management and normal growth and development with all of its variances from following the same kids over years. We must incorporate everything we know from books, lectures, clinical experiences, personal experiences, and more into caring for our patients with the most current evidence based and practical methods available.
And that keeps changing,
keeping pediatricians life long learners!


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It does always seem to take a long time to get round to writing my blog! Must try harder!
After sharing the outcomes from our recent parent consultation regarding communications with Parent Forum last week, I said I would communicate the decisions from the consultation with all parents through my blog and also on the Tranmere Times.
We'd decided to issue a one-off paper copy of this questionnaire as we'd had very few responses using the online survey system set up to investigate the small percentage of parents who'd said they felt unhappy with school communications after the Autumn term parent consultation i-pad survey. We wanted to drill down & find out exactly what it was about communication that this small percentage of parents felt wasn't working well; class communications, whole school communications or something else.
116 families responded to the survey which was much appreciated. In most sections, the very large majority of parents either agreed or strongly agreed with the questions posed, with approximately 2% of parents disagreeing with the questions overall.
10% of families that responded said they would prefer paper communication through book bags rather than via email or website. This has been discussed with both Parent Forum and Governors and it was agreed that this would be a regressive step as paper & reprographics costs for newsletters, etc, to be copied, would be better spent on other resources. We have agreed that we will now make this very clear on our Home School Agreement – that part of the conditions of being part of our school community will be an understanding that the majority of the school communication will be via email or the school website.
Parents felt the Tranmere Times, Parent Consultation evenings, Pupil Mentoring folders and End of Year reports were all valuable methods of communication. Most parents also felt that there was lots of valuable information on the website – some parents felt that the webisite was difficult to navigate but an equal number of parents appreciated the work that Mr Beech had carried out recently to make the website easier to navigate. Facebook and Twitter were also considered to be valuable.
Some parents commented that the Autumn term Parent Consultations were too short and as a result of this feedback we will be making a change – both Parent Consultations will now be 10 minutes long and pupil workbooks will now be available for parents to view at both consultations.
Parents also said that they would like teacher email addresses to be able to ask teachers direct questions. Having discussed this with staff, I said I would reinforce that if parents would like to contact teachers they have a number of options: teachers are always available to talk to at the end of the school day; parents who can't get into school can also ring in to school and ask for teachers to call them back at breaktime,lunchtime or after school and teachers will aim to call them back on the same day; parents are also able to email school with any queries for teachers on the school email address of firstname.lastname@example.com and Mrs Sanderson will forward the e-mail. Teachers will aim to respond within one working day. Parents should be aware that emails received in the evening will not receive a response until the next working day. Teachers are always happy to respond to parental queries.
Some parents also commented that they would prefer it if the Tranmere Times wasn't emailed as a link as it can make it difficult to open on smart phones. The office have investigated this and the programme we use will not allow the document to be sent in any other way (sorry).
The least appreciated methods of communication were Home/School diaries, Parent Forum and Curriculum Bulletins. The Leadership Team are looking into how we can make Home/School diaries or planners a more effective tool to allow effective class communication with home. I'm also investigating the possibility of having a 'Parent Handbook' published for the next school year which would share essential information with all parents. Parent Forum is a useful tool for school as it allows us to 'test' ideas with a representative sample of parents before we launch these ideas whole school. Curriculum Bulletins are an area which we had identified as needing a 'refresher' and so Miss Marsden (who is responsible in school for the management of the curriculum) will be contacting all local ALP schools and all our Noctua partners to ask for examples of their curriculum communication with the aim of relaunching our curriculum information in the new school year.
The very large majority of parents felt that they were well informed regarding school development priorities and school performance through the Tranmere Times, school website and other communications.
Also, the large majority of parents felt that they were well informed as to what their child was learning but there were a number of comments regarding curriculum bulletins with parents saying, 'curriculum bulletins are too brief', 'I read the bulletin but would like more information', and 'I know the topic but would like more detail'. This will hopefully be addressed by revamping our curriculum bulletins – thank you for this helpful feedback.
Some parents said, 'You have to look for the information on the website' and so I have agreed with staff teams that curriculum bulletins will be emailed out with the Tranmere Times in the first week of each half term to make this information easier for parents to access.
With regards to 'Regular Feedback' and 'Knowing Next Steps in Learning', the majority of parents were happy with school provision. Some parents felt that feedback on pupil learning should be more frequent than half termly which is currently the frequency of our feedback – 'a weekly note on progress is needed', 'I don't consider half termly feedback to be regular enough'.
Parents receive Pupil Mentoring folders which report on both progress and next steps for learning in the first half term of each term and either a Parent Consultation or End of Year report in the the second half term of each term. It is statutory to provide feedback termly so our current provision doubles what is expected. I also contacted all other local schools and all our Noctua partner schools to ascertain what other primary schools were providing to their parents – all other local & Noctua schools provide feedback termly with only Tranmere Park and Hawksworth providing feedback half termly. I therefore feel that our feedback on progress is sufficient and would reinforce that parents are always able to contact teachers for more frequent feedback if they have concerns.
The other main strand of your feedback concerned text messaging – parents felt that text reminders were very useful in ensuring they were aware of school events. Text messaging is a cost to school and we buy our texts in 'bundles'. it would be very expensive for school to send text messages out to remind parents of every school event and these are always listed in the Tranmere Times. We use our texts to inform parents of cancelled sports fixtures, to send reminders about payments for residentials etc and for emergencies. We don't wish to incur additional expenses regarding texting but do commit to send a text about non-uniform days which were the most mentioned event in terms of parents feeling 'not informed'!
Thanks so much for your feedback in this consultation – I feel that you raised some pertinent points and the changes that we have made will ensure improved communication going forward.
We also consulted on Extra Curricular provision and I am in the process of analysing your responses which I will discuss with Parent Forum next month and feedback to you via my blog shortly afterwards.


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Opt for you may choose dark or mahogany cherry trees for a rich, luxurious appearance. Pick beds out. Consult your daughter as princess she enjoys the best, then buy princess bedding sets that possess the princess look them. Ensure you have the helper, sheets, pillows, pillowcases, dust, and shams. You can add other single colour cushions to accent that goes along with the princess colour scheme also Make Sure That the fabrics are soft and plush for supreme relaxation
Disney princess duvet cover
Princess tiana toddler mattress,
Pick out accessories to the mattress. You can even add extra detail by twisting the ribbon and tip around the bed stools or bedside table.
With elements out of her crib and brought them to children the bed is a superb way to begin the practice. You might create baby bed a spot for your child. If she loves princesses, Consider shifting her bed into one which matches a princess
Princess sofia size bedding collection,Incoming search terms: japanese princess duvet cover


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Talkoake at 'Kult Urelle Mark Edsdage' in Nørrebroparken, Kobenhaven, as part of The People Speaks tour of Denmark.
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This entry was posted on Friday, October 2nd, 2009 at 6:43 am. It is filed under Past Events, Talkaoke and tagged with Denmark, kobenhavn.
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About Maxiblock
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ENTITY NAME: Tower Hill Limited
EMAIL: firstname.lastname@example.com
We believe Tower Hill Limited has the hallmarks of a scam. We have received a report from a New Zealand resident being contacted by Tower Hill Limited with investment offers. As the company is not a registered financial service provider, it is unable to offer financial services to New Zealand residents and we recommend exercising caution if approached by the company.
Details of the bank accounts used by Tower Hill Limited are as follows:
Account Name: Betters Trading Co. Limited
Bank Name: HANG SENG BANK LIMITED
Account Number: 370292617883
Account Name: EMFA Investment & Trading B.V.
Bank Name: VOLKSBANK
Account Number: DE48 3586 0245 3028 5550 15
Account Name: EMFA Energy Pte Ltd
Bank Name: Standard Chartered Bank
Account Number: 0119975262
Account Name: CESM PTE LTD
Bank Name: UOB
Account Number: 3309057080
Account Name: Minerva Intertrade Pte Ltd
Bank Name: DBS Bank
Account Number: 0489072830
Account Name: STEARNS RUBIN
Bank Name: China Construction Bank (Asia) Corporation Ltd
Account Number: 16100193


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Corruption glaring in Forest Department; Ministry ignorant?
JAMMU: A poor man's death in forest on the mid day of July 12 (in between 12 noon to 1 pm) seems will remain a mystery only as the field Forest Officials have submitted a report to the their office that the man was alone and got killed after he comes under the felling tree. Sources said that the forest officials have showed in their report that the man was alone while felling the tree and came under the tree.
The picture of the tree shows that it was grounded using 'Hand Saw' which is pulled back and forth by two men. So the ground reality falsifies the report of forest department. The reason behind could be best known to them who filed the report. The other thing which indicates there were more men in the area is seizure of 9 trees from the same area which were fell down the same day. Sources informed that Forest Protection Force (FPF) men have seized 9 trees of Far locally known as (Sal) which are decreasing fast in number. If the forest officials have submitted the report, they should explain and tell the grounds, which indicate that he was single man and they should also explain how nine trees were grounded in the area on same day which were later seized by the FPF men.
The most unfortunate and shocking thing the real thing will never come out, as the forest officials have filed such a field report which will never bring reality out. The corrupt officials for just few thousands rupees to protect someone have made the death just a mystery, which more seems as per the circumstance a murder.
Forest Department, the department of Jammu and Kashmir Govt at present under able command and rule of Forest Minister Mian Altaf, has been assigned to take care of forest wealth, but unfortunately the officials are doing contrary resulting is fast ruining of this gift of nature on which the entire life is dependent.
This anti forest nexus has already disturbed the wildlife and brought the life of villagers in danger, by increasing man-animal conflict on which ministry itself have been expressing concerns from time to time.
Earlier, it was forest smugglers doing maximum harm to this gift of nature, now the forest officials themselves are taking the lead in this, and getting the young green trees grounded just for some money notes.
During in-depth investigations, this journalist, (who has been highlighting the issues related to forest and nature since he started his career as a reporter in 2001), found that the corruption is Forest Department has increased many fold and the forest officials are focusing on money only. They are nurturing the anti nature and anti forest activities and for that they have developed a well organized nexus, which under a well designed conspiracy have been misleading the higher-ups manually (on papers) otherwise verbally all seems swimming in the same pond.
During investigation, this reporter came to know that, anyone who wish to fell a tree is granted proper permission after charging the amount of Rs 1088 officially (this is done only to keep records ok) and after obtaining the written permission from the department and receipt of the amount paid, which is given for felling only dry tree of Quail (Pine), the original execution tell a contradictory story in most of the cases, something different from the real execution. People fell down the green Deodar trees in conveyance with the forest officials as for that some rates have been fixed by the officials at different levels in hierarchy (unofficially) which amounts to bribe for permission. The real amount is charged mostly at two levels, which most of the people know. One is by Forest Guard for not reporting the actual felling and the other by Divisional Forest Officer (DFO) for granting permission. Sources said that a Forest Guard, Ghulam Nabi charges Rs 5000 for not reporting the real executing. While the DFO, Manzoor Ahmed Gadoo charges Rs 10, 000 and above, for granting permission. Sometimes, the amount goes up if more trees are grounded.
Sources said that Conservator Forests, Chenab Circle, M.M Gupta is stated to remain most of the time either outstation or in office only while when it comes to field visits, it hardly digests him.
This illegal business by the forest enemies and the forest officials is in practice openly in Forest Division Bhaderwah but one fails to understand what forces higher authorities and people in Ministry and Govt to remain silent on this? Are they involved and directed the field staff to collect the revenue for them? Are they forced to remain silent under some political pressure? Or they want the forests get destroyed fast? This all could be or cannot be but what I observed is something different and applicable too.
What I observed the reason behind government helplessness in every department is people is Govt, bureaucracy believe more on papers only than that of the reality and ground position. Whenever such case is highlighted, and if the public, activists and media pressure is more a probe is initiated. The probe as usual goes through records of the same corrupt department who does the wrong. And people there are so perfect in keeping all the records ok, so how comes any action against them.
The government has to come-up with a long term solution, if it is sincere about the protection of forests,. Government must act in practical, instead of wasting the time of reading the papers prepared by the corrupt officials.
· First the action, than inquiry procedure should be adopted not the first inquiry and than action.
· Officials should be made accountable and the so they visits the fields and do the job for what they were recruited, promoted, given facilities and given handsome salaries.
· Government should form a Special Task Force (STF) of honest and strict people (excluding those who are in government services and politically affiliated) to get the reality out during probes in every department.
· Open up small check posts of these (STFs) after every 5 kilometers so the proper checks are done on every department for maximum results.
· The Government has to, and must show change in dealing corrupt officers, otherwise only making files against these officers is just wastage of time and befooling masses.
(My Mission continues)


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Kenda Shea Grover
Associate Professor of Adult and Lifelong Learning
ADLL Master's Program Coordinator
(RHRC)-Rehab, Human Resources, & Comm.Disorders
Phone: 479-575-2675
Fax: (479) 575-3319
Email: firstname.lastname@example.com
Kenda has been with the Department of Rehabilitation, Human Resources, and Communication Disorders since August of 2003, initially as a student, and following graduation she was hired by the department and is now a member of the RHRC Student Center staff.
- Ed.D. degree in Adult Education
- M.S. degree in Counseling Psychology
- B.A. degree in Psychology
- A.A. degree in Journalism
Currently, Kenda is the Coordinator of Graduate Student Recruitment and Relations. She designs and implements programs to attract students to the program and then to retain them. She also teaches in the B.S.E. degree program in Human Resource Development.


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6 Things I Wish I Had Known Before My Wedding
Weddings are strange things. You can prepare and prepare, but, until you actually do it yourself, you're never quite sure how it's going to be. Before my own wedding, I tried to equip myself with as much knowledge as possible. I read blogs, frequented online forums, and perused magazines until I was probably insufferable to be around for anyone who wasn't planning a wedding. And yet, even with all of that work, there were still a number of important lessons about weddings that I didn't learn until I actually lived through mine. Ironically, these lessons are no longer particularly useful to me, as I'm not planning on having another wedding anytime soon. In order for them not to completely go to waste, I'm now sharing my hard-won knowledge with you, gentle readers. Please benefit from my blood, sweat, and tears. (OK, this is wedding planning, not Game of Thrones, so there wasn't much blood involved. There were definitely a few tears, though.)
1. You won't get everything you want
Unless you have an unlimited budget, you're not going to get every single thing you want at your wedding. So take some time to really think about the elements that matter the most to you, put your money behind them, and let the other details go. I promise, you won't miss the linen napkins you thought you wanted so badly—but you might always regret all the wasted energy you spent pining after them.
2. Plan to have time alone with your new spouse at the wedding
The wedding will be a whirlwind of emotions, and guests, and toasts, and music, and it's going to be both wonderful and overwhelming. Be sure to schedule some time—even if its just a few minutes—for you and your new spouse to be alone after the ceremony. You'll be glad to be able to take a breath and absorb about what you've just done as a couple.
3. Have someone there to coordinate things on the Big Day
I get it: Wedding coordinators can be really expensive. When you're desperately struggling to figure out how to pay for your guests to eat, hiring someone to put together the wedding can seem like an unnecessary expense. Some brides are total badasses who manage to organize their weddings with unshakable calm and nerves of steel. I, however, was not one of those people—and it's perfectly okay if you aren't either. Hiring a coordinator was one of the best decisions I made, even if it did take a huge chunk out of my budget. My advice to other brides is to have someone there who can at least run everything on the wedding day itself. That day, you are going to be overwhelmed and emotional, and the very last thing you'll want to do is deal with behind-the-scenes issues. There are many coordinators out there who offer their services for only the week or day of the wedding, at a much lower cost than what you'd pay for full service. Being able to hand the reigns over to someone else while you go enjoy your wedding will be worth every penny.
4. Delegate as much as possible
Don't be afraid to enlist help from others. When I was planning my wedding, for some reason I felt like I had to handle all of the calling and emailing and spreadsheeting and crafting myself. It was really overwhelming. Only after the wedding did I realize that there were lots of people—my mom, my sisters, my friends—who would have been happy to help, if I had only asked.
5. Decide what photos you want
Well in advance of the wedding, sit down with your fiancé(e), make a list of the photos you want, and give it to your photographer. Everything will be crazy on the day of, but you won't need to worry about making sure you get a picture with your Great Aunt Mildred—your photographer will do it for you. Conversely, also be sure to think about the photos you don't want. If you don't like a lot of posed family pictures, let your photographer know; that way, he or she will know to skip straight to the types of pictures you like best.
6. Don't take on too many DIY projects
I promised myself before the wedding that I wouldn't take on too many craft projects, and yet I still found myself rushing to make custom signage the day before my wedding. I know that it's really easy to just say, "Hey, I could make that myself," but be really careful about how you commit your time. Yes, homemade place cards made of vintage photos would be super cute and personal, but they are not worth your sanity. Give yourself one fun project to work on, and resist all the rest.
Images: Fotolia; Giphy (3)


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With New Delhi must looking for stronger ties with both the maritime and continental powers does not mean the nature and scope of these possibilities is symmetric.
For coalitions to be effective, they need leaders who know how to decentralise power. This is important as the 2019 election is likely to be a choice between two kinds of coalitions.
Securing the eastern Indian Ocean in partnership with Southeast Asian littorals like Singapore, Indonesia, and Thailand could be one of the important near-term Indian contributions to peace and stability in the Indo-Pacific.
A regular survey of experts on matters relating to Middle Eastern and North African politics and security.
After four years, Modi and the Bharatiya Janta Party (BJP) remain the favorite in most of the large states of India, contributing to great opposition coordination for the 2019 election. But if Modi loses popularity, the BJP could be in trouble.
Prime Minister Narendra Modi's trip to Singapore focuses on three increasingly interconnected themes—the strategic, economic, and technological.
The first in-depth investigation of the role money plays in the world's largest democracy.
Following a year marked by mounting tensions between China and India, President Xi Jinping and Prime Minister Narendra Modi met in Wuhan for an informal summit in April to reset the relationship, a momentous event in China-India relations.
Indian Prime Minister Modi's informal summits in Wuhan with Chinese President Xi and Sochi with Russian President Putin are part of the new nimble footed Indian diplomacy toward major powers.
Indian democracy is arguably the biggest loser of the recent drama-filled elections in Karnataka, which are likely to erode trust in the system and cause lasting damage to norms and institutions.
Stay connected to the Global Think Tank with Carnegie's smartphone app for Android and iOS devices


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Train crashes into car in Nanaimo: Another example of a car driver ignoring the dangers of a railway level crossings
Here we have another sad example of a motorist ignoring railway signals and driving into the path of a passenger train, with tragic results. Rail For The Valley must deal with two issues before the reinstatement of the interurban.
1) Before any interurban or streetcar service is to begin in BC, a complete review and updating of the motor vehicles act must take place. When the act was written, taking streetcars (and interurban) into account, motorists in BC drove on the left hand side of the road! This was done in the UK, before the Manchester LRT scheme was built and in France, before there was major investment in new tramway's. It has also been attempted in the USA, but with poorer results ans the anti-LRT lobby has used motor vehicle rules change as the last bastion of defense for their ant-LRT tirades.
2) RFV should advise government that any motorist who ignores a railway signaling device at a level crossing should be given a six month driving ban and any motorist who ignores a railway level crossing signaling device and causes an accident or death, should be given a 10 year driving ban. All interurban signaled controlled level crossings are to be CCTV monitored.
Modern light-rail is one of the safest public transit modes in the world, yet where LRT interfaces with auto traffic, accidents will and do happen and it is best the auto drivers know the law and be compelled to adhere to the law.
The SkyTrain lobby should do well to remember this as well, the annual death rate on SkyTrain is three times higher than the annual death rate on Calgary's LRT, but that is another story.
Train crashes into car in Nanaimo
A man and woman in their 40s are dead
John Streit NANAIMO (NEWS1130) | Wednesday, October 14th, 2009 8:00 pm
NANAIMO (NEWS1130) – Two people are dead after a passenger train slammed into a car at a railway crossing in Nanaimo. It happened around three this afternoon, an older model car travelling on the Island Highway was turning right when it was hit by the Southern Railway of Vancouver Island dayliner.
There were three people in the car at the time – a man and woman in their 40s are dead, a passenger in her 20s was hurt and taken to hospital with unknown injuries. None of the passengers on the train were hurt. Mounties were told the lights and bells on the train crossing were working at the time.


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The Korean company KIA announced the release of the new compact crossover Kia Celtos on the Russian market. A 4370 mm long car will take its place among the soul and sportage models. The novelty should become the main competitor of the best-selling Hyundai Creta. The start of sales in Russia is scheduled for 2020.
At the heart of the new crossover is a modern model platform Q2, on which a number of modern Kia models are based. It should be said that Seltos looks much more interesting than its potential competitor in the face of Hyundai Creta. In front, the crossover has a dynamic and aggressive design thanks to the branded radiator grille and narrow LED headlights.
The interior of the crossover has not disappointed, it looks stylish and even rich, much more interesting than the interior of the same Kreta. In fairness, it should be noted that the cost of Kia Celtos will certainly be higher than the competitor. Returning to the novelty of the interior decoration, we have a "floating" 10.25-inch multimedia system touchscreen, as well as a huge trunk of almost 500 liters according to segment standards. Not surprisingly, Seltos surpassed all B-SUV's "colleagues" in the parameter.
Which swings power power units, it consists of three engines. This database offers a 149-liter, 2.0-liter gasoline engine with a 1.6-liter turbo engine for a 177-horsepower. There is also a 134 horsepower diesel engine. Like a motorcycle box, a 6-speed "automatic", a 7-band "robot" and a QTV. The ride will be both front and full. With what engines Kia Celtos gets to Russia, it's not reported.
Source link


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Scouts on tour
28 Feb 2018
By Ree Maloney
Scouts from the People's Republic of China paid a visit to Docklands last month, including a tour on board the Enterprize.
The scouts were in Australia as part of a 12-day tour with leader Wong Gang.
Docklands News was invited onto the ship but, unfortunately, had to decline. The scouts happily posed for photos. From the happy faces, it was obvious they were enjoying their outing.
The scouts helped the Enterprize crew raise the Melbourne and Australian flags and learnt a little about the running of a tall ship before sailing out into the Yarra with Master of the ship, Richard Tagg.
The Enterprize is a replica tall ship of a vessel that sailed from Van Dieman's Land. In 1835, the original Enterprize sailed north and was occupied by passengers that would become the first white settlers in Melbourne.
The Enterprize runs public day sails, private charters, school education programs and more. For information: www.enterprize.org.au or 9621 1294.
Stay in touch with Docklands. Subscribe to FREE monthly e-Newspaper.
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Small Collections Grant
This page is used to provide assessment scores for the grant. Please use the rubric below the grant details
to enter your assessment score
Mounting, systematization and digitalization of records of the Opuntia (Cactaceae) in Colombia.
Rosalba Ruiz Vega
Database, Digitally image, Process backlog, Other
Cost: $
IH Code
Universidad de Córdoba
• To process material from the Opuntia genus collected in the xerophytic regions of Colombia
• To systematize and digitize the collection of the Opuntia genus deposited in the Herbarium of the University of Córdoba - HUC
• To publish records of the Opuntia genus in the Biodiversity Information System of Colombia - SiB Colombia.
• A review and selection of the specimens to be processed will be carried out, updating the georeferencing of each one. The labels will be prepared according to the format established by the HUC Herbarium. The mounting will be carried out in white double-sided propalcote cardboard of 300 grams. An identifier or code of the herbarium will be assigned to each specimen in the upper left, using a stamp with numbering and acronym of the herbarium. The barcode will be assigned below the herbarium number.
• The Protocol for the Digitalization of herbarium specimens established by the Biological Resources Research Institute Alexander von Humboldt will be used.
Systematization of specimens: A standard template in DarwinCore format will be used for the documentation of biological records in a database carried out in the Excel program.
Digitalization of specimens: image capture will be carried out by means of high-resolution photographs, using the Photo EBox-bio fluorescent light box, Camera control software (EOS Utility 2) and Software to process images (Digital Photo Professional). Each specimen will have a metric ruler and a color chart.
• The process of publishing the information associated with the specimens will be carried out through the following procedure established by the Information System on Biodiversity of Colombia (SiB Colombia): Request registration, Standardize and process the data, Describe and publish the data.
The project will be developed during a period of five months, with working day from 8:00 am - 12 m and from 2:00 - 6:00 pm, developing the following activities chronogram:
• Revision - Selection of specimens: months 1 and 2
• Organization and/or purchase of materials/equipment: month 1
• Taxonomic review, update of the georeferencing of specimens: months 1, 2 and 3
• Label Elaboration: month 3
• Mounting of specimens: months 2 and 3
• Specimens cataloging - bar code assignment: month 3
• Systematization of specimens: months 4 and 5
• Digitalization of specimens: months 4 and 5
• Inclusion of specimens in the collection: month 5
• Integration - Publication of biological records to SiB Colombia: month 5
• Elaboration of final report: month 5
Referee 1:
Referee 2:
Referee name
Scoring Rubric
Your name:
Collection Improvement/Maintenance
1. Contribution to the generation of digital herbarium data (digitization: data entry, setting up database structure, purchasing equipment).
2. Contribution to enhancing our understanding of the flora by making new herbarium specimens available (processing of backlog).
3. Contribution to enhancing our understanding of the flora by making new herbarium specimens available (shipping endangered collection to another herbarium).
4. Contribution towards improving conservation status of specimens in herbarium (better folders, protecting covers, mounting paper, labeling, etc.).
This proposal scores:
IAPT community building
5. Herbarium's potential for success.
6. Perceived need, extent to which the project will benefit from IAPT funding.
7. Sharing specimens with other herbaria.
This proposal scores:
Broader Impacts
8. The project will yield durable benefits (specimens, digitized metadata, databases, websites).
9. The proposed project involves outreach/mentoring and broad dissemination.
This proposal scores:


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Harold Hill independent businesses: 'We are the community'
PUBLISHED: 07:47 16 November 2018
December 1 is Small Business Saturday. As part of a series looking at what our independent shopping parades have to offer, reporter Hayley Anderson finds out why you should hit the high street and shop local this Christmas.
Despite big brands and major supermarket chains continuing to monopolise the everyday shopping experience, small pockets of friendly independent businesses are still thriving up and down the country.
These stalwarts help supply local people with top quality products and the highest levels of customer service.
And this couldn't be more true for places such as Harold Hill where these small shops are at the heart of the community.
From shopkeepers who save fruit and veg for Harold Hill's beloved deer, to a bakery which makes the "best bread pudding on the planet", according to Councillor Jan Sargent, there really is something special about buying from a businesses with a story to tell.
Councillor Jan Sargent said: "When you visit the independent shops here in Harold Hill, you are not visiting solely to purchase something, you are visiting to meet and chat with people who, over the years, you have built up strong relationships with", Cllr Sargent said.
"You'll have to go a long way to find another community spirit that can come close to the fun spirit of Harold Hill."
Dan Wallace, 53, has been the proprietor of florists Flowergirl in Hilldene Avenue, Harold Hill, for the past six years but has been managing the family-run business for the past three decades.
His mum set up the business, which was originally in Petersfield Avenue, 40 years ago and when she retired, he decided to take over.
They are planning to hold a mini celebration to mark the milestone anniversary next year.
He said: "She [mum] was the creative side of things and I was good at the logistics so we worked well as a team.
"It's nice having it as a family business as my wife now does the accounts and the girls we've got have been working here for 20 plus years too so we all work very well together."
Dan believes what makes Flowergirl stand out from other shops is the first class customer service that they always try to provide.
"There have been changes with staff over the years but the high level of service that we provide has always remained the same and I think that's why we always have people coming back.
"Online shopping has taken over the high street.
"Instead of people getting off their backsides to get stuff that they need, they order it online but if we keep going like that, interacting with a computer screen rather than actual people, we'll be just like robots."
Just a few doors down, owner of hairdressers Scissor Lounge, 31-year-old Sabi Hasguler, continues to work hard alongside her team to perfect residents' hair-dos.
Before buying the shop which used to be called Hair Connections in August 2016, Sabi managed salons around Essex but longed to open up her own business.
After purchasing the shop, Scissor Lounge was closed for five weeks while they carried out a major refurbishment to make it look as good as new.
"It's been my dream to open up my own salon so was really excited when I finally got the chance to", she said.
"The old salon that used to be here was quite outdated, so it didn't get a lot of business and that's why we decided to give it a complete makeover.
"Our customers come back to us because they trust that we can give them an amazing look.
"When you spend money at an independent shop, you're investing in the local area and that's what I would like to see more of in the future.
"Smaller businesses need support from its community because we are the community."
The Small Business Saturday campaign, which began in America 10 years ago, has become an international movement, with independent business owners and shoppers alike showing their ongoing support.
So why not show yours by visiting this friendly community.
If you value what this story gives you, please consider supporting the Romford Recorder. Click the link in the orange box above for details.


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To what do you owe your love of storytelling?
I've always been a daydreamer - spending countless hours making up worlds I've never been to and people I've never met. When I snap out of it, there's this guilty feeling that lingers because of the time that's just flown by. Creating stories feels like the most practical way of making sense of all the time I spend daydreaming.
What were your all-time favourite childhood books or stories?
Fruits Basket. Gosh, the first time I ever read manga - more specifically, shoujo manga - a whole new world opened up to me. The idea that the journeys your emotions take you on was worthy enough of getting made into a 20+ volume series comics, resonated with me so much. Fruits Basket was the epitome of what that genre meant to me and I still think about it to this day.
As an illustrator, what would you choose as your mascot or avatar?
The Virginia Opossum. Very resilient critters.
What literary pilgrimages have you gone on?
Tomato Lake in Belmont. Its mystery, the urban legends surrounding it, and the all-round beauty of the place makes it the ideal spot to daydream.
If you could tell your younger self anything, what would it be?
Good job at documenting all your daydreams and forcing your math tutor to read your first attempt a magnum opus. Sometimes you need to be your biggest fan.
What do you think most characterises your work?
Big Mood. I love making a big deal about emotional growth and the ride it takes us on.
What do you do when you are not creating?
Watching Star Trek Deep Space Nine with my boyfriend and rats. Then reading the screenplays of each episode of that show. Deep Space Nine is a really good show.
Where do you find your ideas?
Daydreaming. Truly, I'm not messing around with this daydreaming stuff.
How do you know when a story is finished?
When I know I've made my point.


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No Palm Oil Mince Pie Magic
Thinking about getting ahead for Christmas? There's nothing nice than a jar of homemade mince pie filling all ready to pop in your pastry.
But not everyone has time to cook – and if you are concerned about the effect of the use of palm oil has on the environment and our health, then the news that Iceland's Luxury Mince Pies are made without this ingredient is very good to hear. And the good news is that you can also buy them in Selfridges Stores? How festively yummy is that!
From £1.89 per six.
For more information on global deforestation visit


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Do you suffer from friggatriskaidekaphobia? If so, then you will be riddled with fear all day today because friggatriskaidekaphobia is a fear of Friday the 13th. Are you superstitious? Are you afraid to go to work today? Are you scared to eat dinner in a restaurant? I'm not any of those things, so Happy Friday the 13th!
Believe it or not, this is one of the most wide spread susperstitions in the US. "An estimated 17 to 21 million people in the US are affected by a fear of this day making it the most feared day and date in history. Some people are so paralyzed by fear that they avoid their normal routines in doing business, taking flights or even getting out of bed." Get a grip people!
There are a whole bunch of reasons why 13 is considered an unlucky number and why Friday is considered to be an unlucky day, but if you are of my generation or after, Friday the 13th most likely conjures up images of Jason Vorhees and his scary mother who killed everyone at Camp Crystal Lake. I saw the original one in the theater in 1980 and it scared the shit out of me because I believe that in any woodsy, dark area, a killer is just waiting to jump out of the bushes and kill me and whoever I'm with.
I also believe that there are killers in the woods behind my mom's house, and when I visit I always picture him, sometimes with a hockey mask and sometimes without, peering in the window while I'm watching Family Fued alone and of course, there's a thunder storm outside. She lives in Maine, which is a dark and scary state. Why do you think Stephen King lives there? It's called inspiration.
Friday the 13th was such a great slasher film at the time that, of course, Hollywood had to go and make:
Friday the 13th: part II (1981)
Friday the 13th: part III (1982)
Friday the 13th: The Final Chapter (1984)
Friday the 13th: A New Beginning (1985)
Friday the 13th Part VI: Jason Lives (1986)
Friday the 13th Part VII: The New Blood (1988)
Friday the 13th Part VIII: Jason Takes Manhattan (1989)
Jason Goes to Hell: The Final Friday (1993)
Jason X (2000)
Freddy vs. Jason (That's Freddy Kruger, of course) (2003)
Friday the 13th (the remake of the original) (2009)
Do you think Hollywood has a stable of dead horses that producers go in and beat on a regular basis?
Fun fact: My brother's friend, Derek Mears, played Jason in the remake. I watched it just for him. Of course, my favorite thing about slasher films is the stereotypical dumb girl who is always left alone and hears a noise and assumes it's her boyfriend just trying to scare her. "Billy, is that you? Billy! C'mon Billy, it's not funny anymore" and then she gets killed because she's a slut. Did you ever notice in slasher films how the slutty girls always get killed? That's fine, because the slutty ones are always stupid, and I'm totally okay with anyone stupid getting chopped up. In fact, I'd like to do it myself. I guess all I need is a hockey mask, which I don't have, but I do have plenty of knives.
Well, I have to go now because I have a piece of processed breakfast meat cooking that I need to tend to. I hope everyone has a very lucky Friday the 13th!
In the comment section, I would love if you put your favorite slasher movie of all time….


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BARRINGTON, RI — A 97-year-old woman apparently slipped and fell while walking to her car. Her twin sister, running into the house to call for help, tripped on a rug.
Both were found dead the next morning, and police believe they may have frozen to death.
The tragic deaths took place over the weekend in Barrington, Rhode Island.
Martha Williams was walking to her house after having dinner with her sister Jean Haley on Friday. Their younger sister, an 89-year-old woman, had dropped them off and was on her way home.
Police believe Martha Williams slipped in the driveway. Her twin sister, police believe, fell in the garage while running to get help.
A neighbor noticed Martha Williams's body in the driveway and called 911.
"Ms. Williams may have fallen in the driveway," Police Chief John LaCoss said in a statement. "Ms. Haley may have tripped on a rug on the floor of the garage as she attempted to enter her house to call for assistance."
The precise cause of death hasn't been issued but extremely cold temperatures might have been a factor in the deaths, La Coss said.


text: Hello...We have a PT who has a referral for a patient with a Medicare Advantage plan that doesn't cover out of network providers. Although the provider is contracted with Medicare, she is not contracted with the MA plan. The patient doesn't care if she's OON and wants to pay cash. Is this allowed since she's technically a Medicare patient?


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Colleen Dale MSW, LGSW
Mental Health Therapist
Location/ Program
New Hope Outpatient, Dialectical Behavior Therapy, School Based Programs
Joined VOA
Clinical Approach
I provide individual therapy, family therapy, play therapy, and DBT therapy serving children, adolescents, adults, and families in the school and outpatient setting. I aim first and foremost to build a sincere and trusting relationship using compassion, humor, and authenticity--while also integrating techniques from mindfulness, motivational interviewing, cognitive behavioral therapy, and dialectical behavior therapy.
Areas of experience and interest
I have nine years of experience supporting and building relationships with children and adolescents through my work within community-engagement organizations, schools, and a foster care agency. I support those experiencing emotional difficulties including but not limited to: anxiety, depression, emotional dysregulation, ADHD, mood disorders, trauma, and difficulties adjusting to major life transitions.
Specialty Training and Certifications
Licensed Graduate Clinical Social Worker (LGSW)
Dialectical Behavioral Therapy (DBT)
Play Therapy
Master of Social Work—University of Minnesota (Concentration in Clinical Mental Health)


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Welcome to Memory Keepers
The Memory Keepers Medical Discovery Team is focused on understanding the dynamics of diabetes and dementia as interacting conditions among people living in tribal and rural communities. Led by Dr. Neil Henderson (Oklahoma Choctaw), the team will work to preserve brain health by collaborative, community based research. The origin of the name,"Memory Keepers" Medical Discovery Team is significant. In many American Indian cultures, respected adults and elders of the tribe are responsible for preserving sacred medicine bundles, songs, and stories. By prevention and aggressive management of diabetes, the risk of vascular, Alzheimer's, and other dementias can be reduced. In this spirit, the research to preserve brain health will enable American Indian communities to continue to benefit from the wisdom of their adults and elders far into the future.
Vision:Advancing the boundaries of health equity research to create innovative interventions to support healthy aging in American Indian and Rural populations.
Mission:The mission of the Memory Keepers Medical Discovery Team is to support an environment of Team Science to conduct community-based participatory action research on diabetes and dementia in American Indian and rural communities with the aim of achieving health equity.


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Plan for the financial and emotive aspects of choosing the right Aged Care Option.
For most of us it is can be a difficult discussion to have with our family and friends. However it is very important that your family understand your wishes when it comes to care as you get older and how you would like to fund this care.
The Living Longer Living Better Government initiatives have been rolling in over the last couple of years with the majority of the financial changes taking effect from 1st July 2014.
It is important to understand the financial implications and options when considering your Aged Care options and the advisers at Aged Care Financial Advisers are here to support you.
We will continue to guide you as to the financial options to stay at home, potentially move into an Aged Care facility as a new resident with standard needs or special needs care (such as dementia).
Retain your Age Pension
A change in your circumstances can mean being re assessed for Centrelink or DVA entitlements. This can be an overwhelming time and it is best to see a specialist who can assist you to maximise your benefits.
Contact us prior to making any financial decisions, the initial appointment is complimentary.


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By JieYing PengTravel insurance has become an essential item to pack for smart travelers whether it's for your trip, possessions, luggage, or health. You trip could be ruined without the right kind of travel insurance. The purchasing of travel insurance has increased 10 percent after 9/11. . The top three reasons are: peace of mind, protection against the unexpected and concern over losing the financial investment in a trip.
Here are top reasons to buy travel insurance:
1. Your flight has been cancelled.
2. Your bag was lost with your insulin inside. You need help to locate your bag as soon as possible and have your emergency prescription filled. Who do you call?
3. Your first visit to Asia, and your passport and wallet are stolen. Where do you turn for emergency cash, and how will you get your passport replaced?
4. You're involved in an accident and adequate medical treatment is not available. You need medical evacuation.
5. You need to cancel your trip due to illness.
6. Your cruise line, airline or tour operator goes bankrupt. You need your non-refundable expenses covered and to get to your destination.
7. You have a medical emergency in a foreign country.
8. A terrorist incident occurs in the city where you're planning to visit and you want to cancel your trip.
9. A hurricane forces you to evacuate your resort, hotel or cruise.
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