We put forward a new method of constructing the complete ordered field of real numbers from the ordered field of rational numbers. Our method is a generalization of that of A. Knopfmacher and J. Knopfmacher. Our result implies that there exist infinitely many ways of constructing the complete ordered field of real numbers. As an application of our results, we prove the irrationality of certain numbers.


The application of neural networks technology to real-time
processing of biometric identification demands the
development of a new processing structure that allows
efficient hardware implementation of the neural networks
mechanism. This paper describes a VHDL modeling
environment of IRIS recognition for biometric identification
using neural network to ease the description, verification,
simulation and hardware realization of this kind of systems.
Iris has unique features to be used as a biometric signature
due to its speed, simplicity, accuracy, and applicability. The
processes of the project consist of two main parts, which are
image processing and recognition. Image processing done
by using Matlab where back propagation was used for
recognition. The iris recognition neural network
architecture comprises three layers: input layer with three
neurons, hidden layer with two neurons and output layer
with one neuron. Sigmoid transfer function is used for both
hidden layer and output layer neurons. Neuron of each layer
is modeled individually using behavioral VHDL. The layers
are then connected using structural VHDL. This is followed
by the timing analysis for the validation, functionality and
performance of the designated model. Iris vector from
captured human iris has been used to validate the
effectiveness of the model. Test on the sample of 100 data
showed an accuracy of 88.6% in recognizing the sample of
irises.


The invention relates to a self-sufficient hydraulic linear drive with a hydraulic arrangement and method for operating this. The hydraulic system comprising a pump unit (27), a surge tank (28) and at least one automatically switching Lastumschaltventil (16) preferably for switching between a Eilausfahren and a Lastausfahren, wherein the Lastumschaltventil (16) is associated with a hysteresis circuit (17). By the hysteresis circuit (17) a first switching operation of the diverter switch valve (16) is triggered at a first predetermined applied control pressure and a second switching operation is triggered at a deviating from the first predetermined control pressure second control pressure.


dietary influencing factors, smoking practice, in general, has fallen with adults, although not, very unfortunately, with children (Foulds and Godfrey, 1995). The hope for a higher level of physical activity is virtually a non-starter, at least in the general population (Crespo et al, 1996). So, in view of almost universal inertia, and of disinterest in the masses, it could be asked pragmatically does it really matter terribly much if people don't or won't take on a


This paper investigates isolated speaker- dependent word recognition of Diagnostic Rhyme Test words using a backpropagation neural network classifier. The performance of K-nearest neighbors and closest-class-mean classifiers are compared for several signal- to-noise ratios. The test and training data consisted of 40 frames of weighted eighth- order cepstral coefficients extracted from each word utterance. The neural network classifier correctly classified more than 92% of 2,400 testing examples not contained in the training data for the noise-free case. This performance was better than that of the K-nearest neighbor classifier, which was greater than 83%, and that of the closest class mean classifier, which was greater than 85%.


The effect of elliptic orbit motion on the blurring in an optical sensor was evaluated. The magnitude of the uncompensated relative velocity, the smear velocity, can influence the selection of an orbit for the mission as well as the signal processing requirements. A model of the orbital kinematics and the optical projection effects for a surveillance spacecraft was developed in order to determine the smear velocity. The center of the sensor's field of view (CFOV) is assumed to be directed to track a point of interest on the earth's surface in order to reduce the relative motion. Two different modes of tracking the point are considered: two-axis tracking and three-axis tracking. The lateral variation of the smear velocity across the field of view (FOV) was analyzed. This effect, in conjunction with the frame time, contributes to the smearing or blurring of the image. It must be assessed along with the clutter effects in an evaluation of the image degradation. The smear velocity may range from zero to over 300 meter/second in a typical orbit. The effect would be greater than the effect of drifting clouds in the background. The effect generally increases with increased displacement from the CFOV, and it changes significantly with the observation position along the elliptic orbit.


Many students find traditional lectures, routine memorization, and restatement of facts and terms tedious and boring (Munoz and Huser, 2008). This requires professors to employ a variety of teaching techniques, for example, live case classroom projects. Such an experiential learning opportunity encourages students to become involved with the materials they are attempting to learn by requiring them to apply theory to real-life situations where ambiguity, change, and risk exist (Lewis and Williams, 1994). This paper presents an assessment of a semester long marketing plan competition, which was incorporated into the Marketing Management Course. The competition required all student teams to deal with the assigned client and compete with each other to produce the winning marketing plan. Student feedbacks indicated they enjoyed the experiential learning opportunity and the competition format.


The Overall City Technology Process (OCTP) intends to bring state-of-the-art science and technology to bear on City problems and to integrate the technology transfer process into the City's regular decision-making process. First year achievements included the integration of the technology assessment and application process into the City's Annual Budget process and the involvement of significant City staff in technology assessment, priority setting, and application activities. Second year objectives were to follow through on previous specific projects and to concentrate application of innovative technology in two specific areas: municipal energy conservation and program performance measurement. These are among the City's high priority management initiatives. Seattle's two-year experience with the OCTP Project revealed that: (1) technology improvement proposals must match the City's general policy and budget priorities; (2) review of these proposals must be integrated with the existing decision-making process; (3) collection and dissemination of technology information should be centralized within the City; (4) the national communication network regarding innovative technology is ineffective at the local level; and (5) the City of Seattle has benefited from the implementation of the OCTP Project.


In this paper we propose a new approach to manage alerts flooding in IDSs. The proposed approach uses semantic analysis and ontology engineering techniques to combine and fuse two or more raw IDS alerts into one summarized hybrid/meta-alert. Our approach applies a new method based on measuring the semantic similarity between IDS alerts attributes to identify the alerts that are suitable for aggregation and summarization. In contrast to previous works our approach ensures that the aggregated alerts will not lose any valuable information existing in the raw alerts set. The experimental results show that our approach is effective and efficient in fusing massive number of alerts compared to previous works in the area.


In order to analyze power relationships in married couples, I have proposed a typolo- gy that classifies relationships between women and men around an axe th...


This article examines the festive musical practices of Chinese immigrants from 1949 to 1988 in central Rangoon. Eschewing conventional interpretations of diasporic music that view a diasporic community as a fixed unit, the author adopts the mode of ethnographic historiography and focuses on multiple micromusics that emerged in the Burmese Chinese community. This speaks to the music's performativity of difference whereby music is used as a strategic resource to help articulate differences and lay claim to subjectivity.


Surface roughness was regarded as an essential indicator of the quality of machining. In machining demands, it was often necessary that the surface roughness of the workpiece lies in a specific range.For this reason , it was significant to detect the surface roughness level of the workpiece. For the traditional roughness detection methods with high manual involvement and unable to achieve automation, this paper proposed a new artificial intelligence detection approach. The approach consisted of a 1-Dimensional Convolutional Neural Network (1DCNN) and a Bi-directional Gated Recurrent Unit Network(BiGRU), called the 1DCNN-BiGRU model. 1DCNN-BiGRU accomplished the detection of roughness levels by classifying surface images directly, without extracting specific roughness features. First, 1DCNN was applied to automate the extraction of roughness-related features along the texture direction of the product surface image. Subsequently, the feature sequences extracted by 1DCNN were fed into BiGRU to learn the overall dependence of the roughness on the sequences. Experiments were performed on a 45steel workpiece roughness image dataset. The 1DCNN-BiGRU model gave 90.60% and 88.06% detection performance on the training and test sets, respectively.


We have undertaken the characterization of the low-temperature direct electron cyclotron resonance (ECR) N2O plasma process on the technically important Si(100) surface by the combined use of the newly developed ultrahigh vacuum (UHV)-based contactless capacitance–voltage (C–V) and x-ray photoelectron spectroscopy (XPS) techniques. An UHV-based contactless C–V measurement system allowed for the first time a direct in situ assessment of electronic properties of "free" Si surfaces and the surfaces covered with an ultrathin insulator layer. The UHV contactless C–V analysis indicated that a oxynitride/Si interface with a minimum interface state density of 1×1011 eV−1 cm−2 could be realized by the ECR N2O oxynitridation process at 400 °C. The angle-resolved XPS study showed that the formation of a phase-separated Si3N4/SiO2 structure is important to realize such a interface at low temperatures. The electronic and the chemical properties of the interfaces were found to be strongly correlated.


The history of dietary guidelines for heart health — a project begun in the 1950s when the United States felt threatened by a perceived "epidemic" of heart attacks — reveals that the Mediterranean diet's cardiovascular benefits have been recognized for decades.


Evidence is presented that the genome of the infecting poliovirus must be intact in order to achieve inhibition of cellular protein synthesis. Viral particles with a single lethal hit by treatment with hydroxylamine no longer participate in the inhibitory action of the virus. De novo protein synthesis is required for the inhibition to occur. The synthesis of cellular m-RNA is not necessary.


Fibrolamellar Hepatocellular Carcinoma (FL‐HCC) is a rare primary liver tumor that usually presents in younger patients without underlying liver disease.


In this article, a novel SiC trench MOSFET with deep <inline-formula> <tex-math notation="LaTeX">$\text{p}^{+}$ </tex-math></inline-formula> shielded regions and current spreading layers (CSLs) (DPCSL-MOS) is proposed and studied by TCAD simulations. The results show that the introduction of the deep <inline-formula> <tex-math notation="LaTeX">$\text{p}^{+}$ </tex-math></inline-formula> shielded region reduces the transfer capacitance <inline-formula> <tex-math notation="LaTeX">${C}_{rss}$ </tex-math></inline-formula> (<inline-formula> <tex-math notation="LaTeX">$= {C}_{gd}$ </tex-math></inline-formula>) and the saturation current, thus reducing the total switching losses and increasing the short-circuit capability. Besides, the deep <inline-formula> <tex-math notation="LaTeX">$\text{p}^{+}$ </tex-math></inline-formula> regions around the source trench efficiently shields the shallow gate trench from the drain voltage, thus reducing the maximum oxide electric field. In addition, the introduction of CSL with higher doping concentration than the drift layer brings down the JFET effect and the resultant device ON-resistance. The dynamic figure of merit (FOM) (<inline-formula> <tex-math notation="LaTeX">${R}_{\text {ON}}\, \ast\, {Q}_{\text {gd}}$ </tex-math></inline-formula>) is significantly improved with no degradation in terms of the static FOM (<inline-formula> <tex-math notation="LaTeX">${V}_{\text {br}}^{2}/{R}_{\text {ON}}$ </tex-math></inline-formula>). Therefore, the proposed DPCSL-MOS is a more robust and promising structure for power electronic systems, especially for the high-frequency applications.


A negative resistance generator includes first and sec ond terminals; first and second inductors connected in series between the terminals; and a semiconductor am plifying device having a first control electrode con nected to the first terminal and a first active electrode connected to the second terminal and a second active electrode connected to the junction of the inductors. When employed in an active filter resonator a first vari able capacitor is interconnected with the inductors for setting the resonant frequency of the resonator. The resonators may be combined in an active filter with a transmission line where each of the resonators is inter connected to the line by decreasing resistance from the input to the output in order to balance the rf currents to which the resonators are subjected. An improved dual loop active filter control system is achieved by using a master oscillator that employs a resonator that is matched to the active filter resonator in the filter and servoing the frequency and Q-factor controls so that the drive signals are compensated for temperature drifts, manufacturing tolerances, and other problems while a buffer amplifier is used between the master oscillator and the frequency and gain control loops for isolating the master oscillator reference circuit from the loading of the loops and from the perturbation introduced by the frequency reference signal; a frequency shifting circuit in the frequency control loop permits the refer ence signal to be shifted to a lower or higher frequency than that of the master oscillator.


The actural spring is stereoscopic,and crude.Specially there are a strut circle in each side.The article discusses the method with which how to draw the stereoscopic spring with crudeness and two strut circle.


Results from various phase 3 clinical studies have demonstrated the efficacy of canakinumab to treat patients with systemic juvenile idiopathic arthirtis (sJIA). However, limited information is available on the long-term efficacy and safety of this drug to treat children with sJIA.To evaluate the long-term efficacy and safety of canakinumab in patients with sJIA treated at the National Medical Research Center of Children`s health, Moscow, Russia.This was a prospective, single-center study that included canakinumab (CAN)-naive patients diagnosed with sJIA following the International League of Associations for Rheumatology (ILAR) criteria and start receiving CAN treatment from 10/2012 to 03/2016. Patients included in this study also participated, for defined periods of time, in the clinical trialNCT02296424. Patients with active disease started treatment with canakinumab 4 mg/kg. A treat-to-target approach was used, canakinumab was discontinued in patients on clinical remission, either following theNCT02296424protocol or by investigator's decision, and re-introduced in those patients who experienced a relapse afterwards. Disease characteristics and demographics were recorded at the time of diagnosis and initiation of treatment (study entry). Disease activity was evaluated periodically using the adaptedJIAACR core set measures, and percentages of patients with inactive disease and on clinical remission were calculated using the sJIA ACR criteria. Response to treatment was also evaluated by calculating modified ACR responses and JADAS-71 scores. Safety was assessed by collecting and classifying adverse events (AEs) at each visit.Nineteen patients presenting with sJIA were included in this study, with a median age at treatment initiation of 9.6 (interquartile range, IQR 6.4-11.1) years and a median disease duration of 4.4 (IQR 1.2-7.0) years. Most patients (17/19) had been treated previously with one or more biologic agents for sJIA. As of 23 December of 2019, the median time of follow up was 55.5 (47-71.7) months, with all patients being followed for at least 3.5 years and 5 patients followed for more than 7 years. As it is shown in figure 1, most patients (16/19) were on clinical remission one year after starting therapy, and this effect was sustained at year 3.5 (17/19). ACR 90 responses were observed in 84.2% (16/19) patients at one year and 94.7% (18/19) patients at 3.5 years, whereas JADAS-71 scores decreased from 15 (14: 28.5) at baseline to 0 (0: 0) at one year with 4/19 patients maintained with JADAS-71 >0); at 3.5 years, only one patient had JADAS-71>0 (0.47, due to slight ESR increasing). Concerning the 5 patients with >7 years of follow up, three of them were in clinical remission for more than 3 years, including one who had discontinued therapy more than 2 years. Another patient had a relapse after attempting drug discontinuation, but recovered clinical remission after reintroducing canakinumab, and remained in this state for the last two years. The remaining patient has persistent low levels of disease activity during the last four years of follow up. AEs required hospitalization were reported in 36.8% (7/19) patients.Sustained clinical remission was observed in most patients with sJIA treated with canakinumab for up to 7 years, with no new or unexpected adverse events reported.Ekaterina Alexeeva Grant/research support from: Roche, Pfizer, Centocor, Novartis, Speakers bureau: Roche, Novartis, Pfizer., Elizaveta Krekhova: None declared, Tatyana Dvoryakovskaya: None declared, Ksenia Isaeva: None declared, Aleksandra Chomakhidze: None declared, Evgeniya Chistyakova: None declared, Olga Lomakina: None declared, Rina Denisova: None declared, Anna Mamutova: None declared, Anna Fetisova: None declared, Marina Gautier: None declared, Dariya Vankova: None declared, Meyri Shingarova: None declared, Ivan Kriulin: None declared, Alina Alshevskaya: None declared, Andrey Moskalev: None declared


Molecular evolution of humanH3N2 influenza A viruses (IAV) has included the progressive addition of N‐linked glycans onto the hemagglutinin(HA) globular head. The pandemic H3N2 virus A/Hong Kong/1/1968 (HK68) possessed only two glycosylation sites on the HA globular head at residues 81 and 165. In 1975 and 1999, periods of significant antigenic change, H3N2 IAV acquiredglycans at residues 63 and 126 (HK68+2) and residues 63, 126, 133, and 246(HK68+4), respectively. Differences in receptor binding, pathogenicity, and induction of T‐cell‐mediated immunopathology in mice between the HK68 and its glycosylation variants have previously been demonstrated. Here, we evaluated the consequences of this incremental glycosylation on antibody responses directed to HA. Total serum antibody titers against HA were measured 15 days after infection of mice with 105 TCID50 of each virus by hemagglutination inhibition assay (HI) with various red blood cells (RBC) at room temperature (RT). The avidity was measured at 37°C. Sera from mice infected with any virus showed reactivity against all tested HAs. However, sera from mice infected with HK68 and HK68+2 (lower glycosylation) demonstrated relatively low reactivity against higher glycosylated HK68+4. Sera from HK68+4‐infected mice recognized all tested HAs at similar levels. Viral pathogenicity did not correlate with antibody titers or avidity, since moderate titers and avidity were observed with viruses of highest and lowest pathogenicity (HK68 and HK69+4 respectively), while higher titers and avidity were seen in sera of mice infected with HK68+2, whose pathogenicity is intermediate between HK69 and HK68+4. The data suggest that HA antibody responses may be influenced by HA glycan composition in ways that are unconnected to pathogenicity. Modification of N‐linked glycosylation of the HA globular head may present a new approach for improvement of IAV vaccine efficacy.


This research starts from the perspective of coaching ability of football coaches of colleges and universities in China, and carries out an overall analysis for the current status of coaches' teaching ability, so as to strengthen the coaching ability of football coaches in colleges and universities, enhance the development level of college football in China, and promote the level of socialization of football in China. It also provides a scientific and effective practice and theoretical basis for the teaching, training and scientific research of college football projects in China, and has a certain reference for improving the football level of colleges and universities in China. Football coaches occupy an important position in college football teaching, so their coaching ability directly determines the quality of college football teaching. However, there are many factors that affect the coaching ability in the actual work of football coaches in colleges and universities. Therefore, football coaches in colleges and universities must adopt effective measures to improve their coaching ability on the basis of the analysis of the factors affecting their coaching ability, so as to improve the quality of college football teaching. Keywords—football coaches in colleges and universities; working ability; influencing factors


In order to improve the standardization and maneuverability of the process of working condition de- tecting for armored vehicle,based on the study and analysis on the inspection method of the state detecting parameters and technical performance for track armored vehicles,the selecting method and gist of detecting parameters during the working condition detecting is analyzed in this paper,and the working condition param- eters of every mechanical systems for the typical armored vehicle is also listed.


A series of LiGd5P2O13 : Eu3+ phosphors with a red-emitting band centered at 622 nm were synthesized by a high temperature solid-state reaction method. Structure-luminescence correlation, concentration quenching and thermal stability of the LiGd5P2O13 : Eu3+ phosphors were studied combined with XRD, PL/PLE spectra as well as temperature-dependent PL and decay curves. The optimum concentration of Eu3+ doped in the LiGd5P2O13 is 20 mol%, and the corresponding concentration quenching mechanism is found to be via dipole/quadrupole–quadrupole interactions. Intensity parameters (Ω2 and Ω4) and various radiative properties such as transition rates (A), branching ratios (β) and stimulated emission cross-section (δe) were calculated using the Judd–Ofelt theory. LiGd5P2O13 : Eu3+ exhibited good thermal stability and its emission intensity decreased slightly at temperature above 150 °C. The CIE coordinates of LiGd5P2O13 : 0.20Eu3+ (0.644, 0.339) are very close to s-RGB standard red (0.640, 0.330), and the corresponding quantum efficiency is 46.5%. The results show that LGPO : Eu3+ may be considered as a potential red emitting phosphor for NUV/blue pumped WLEDs.


The purpose of this investigation was 1) to establish an optimal technique for isolating osteoprogenitor cells in vitro using human femoral cancellous bone as a donor site, and 2) to evaluate the effects of various factors on differentiation of osteoprogenitor cultures. Two isolation techniques evaluated were enzyme digestion and primary explant technique. Furthermore, bone morphogenetic protein 2 (BMP-2) and doxycycline were supplemented in a dose dependent manner into various osteoprogenitor cell containing culture dishes. To compare isolation techniques and the effect of supplemented factors, we isolated cell populations from cancellous bone of the femoral neck from 7 and 6 patients, respectively, with osteoarthritis undergoing total hip replacement surgery. Bone derived osteoblasts and their bone nodules were identified using Von Kossa stain. The cell yield of the two isolation techniques was quantified by hemocytometer counts. The ability of the cells to differentiate into bone forming osteoblasts was evaluated by comparing numbers ofVon Kossa positive nodule counts. Using alkaline phosphatase (ALP) staining, ALP quantitative assay and osteocalcin polymerase chain reaction, our study is the first attempt to determine the effects ofdoxycycline, along with the more commonly used BMP-2, on the differentiation of osteoblasts into bone forming colonies.


Neonatal jaundice (neonatal hyperbilirubinemia) is a physiological process caused by degradation of foetal erythrocytes. In humans, it starts in the second day of life and finishes at about day 10. During this short period in the organism of neonate large amounts of bilirubin – product of heme decay are generated as an effect of haemolysis of foetal erythrocytes. Because of impaired bilirubin clearance, excess of this compound circulates in the body, infiltrates to the skin and mucosa, giving them characteristic, yellow colour. Accumulation of unconjugated bilirubin is highly toxic, because this compound can diffuse through blood-brain barrier and cause damage of brain structures, especially the basal nuclei. According to the present knowledge, liver and spleen are the main organs, which participate in clearance of haemoglobin degradation products formed during haemolysis. In this project we show that also kidneys are involved in the process of heme detoxification and iron utilization in neonatal individuals. In our study we used 3, 5, 7, 9 and 11 day-old male mice as a mammalian model organisms. To confirm that tested animals undergo neonatal jaundice and haemolysis we measured bilirubin, haptoglobin and hemopexin levels in plasma. Kidneys were analysed for a wide panel of proteins involved in iron metabolism, including iron importers (DMT1, TfR1), heme transporters (HCP1, HRG1, FLVCR2), heme oxygenase 1 and 2 (HO-1, HO-2) and ferroportin (FPN), iron exporter. In this study we report that heme and iron transporters and heme oxygenase 1 are highly expressed in the cells of the renal tubules. Our results suggest that kidneys may play an important role in postpartum iron recirculation when the metabolism of this element depends primarily on iron stored in the liver.


growth-promoting effect on the male reproductive tract. By contrast, the stimulatory effect of these hormones on nitrogen balance and body weight is referred to as their anabolic action (Kochakian, 1975). This latter effect results from androgen stimulation of protein synthesis in tissues such as liver, kidney, bone and muscle which comprise a major portion of body mass. The impetus to distinguish between anabolic and androgenic effects of testosterone and other androgens was provided by physicians interested in developing steroids with anabolic but not androgenic activity. As a result, the actions of many androgens were compared on the reproductive tract and on end points believed to reflect anabolic response including muscle hypertrophy, nitrogen retention and kidney growth. Results indicating an apparent dissociation of androgenic and anabolic activities were thought to support the contention that these were 2 distinct actions (Kochakian, 1975). However, there was also a dissociation of the androgenic effects of a single steroid on 2 tissues of the reproductive tract, such as seminal vesicle and prostate. This


A case of pemphigus foliaceus is presented which has had typical bullous lesions clinically and showed the presence of anti-epidermal antibody, LE cells and antinuclear antibody in the serum. The association these unusual serological phenomena in this patient suggest a basic disturbance of immunity in the pemphigus.


Franz Kafka claimed that he wanted to write fairy tales, but couldn't. Nevertheless, the element of magic, the occurrence of the inexplicable, which prevails in fairy tales, has a prominent place in Kafka's fiction, and occasionally motifs are directly borrowed from the Marchen. The appearance of a brother and sister (she is Grete) in "Metamorphosis," for instance, points unequivocally to one of the most famous stories in the Grimms' Kinderund Hausmarchen. Less ambiguously employed and more pertinent to the development of die plot is the fairy-tale topos of the two brothers which figures in "The Judgment."


The article discusses an application of Kullback-Leibler divergence to the recognition of speech signals and suggests three algorithms implementing this divergence criterion: correlation algorithm, spectral algorithm and filter algorithm. Discussion covers an original approach to the problem of speech variability and is illustrated with results of experimental speech signal modeling. The article gives a number of recommendations on the choice of appropriate model parameters and provides a comparison to some other methods of speech recognition.


Two principal experiments were conducted, in which synthesis activity, selectivity, and the bulk catalyst composition were monitored for approximately the initial 200 hours on stream. One was performed at 248/sup 0/C (run Fe22) and one at 232/sup 0/C (run Fe27), with an intermediate period at 263/sup 0/C. A third experiment (run Fe24) was conducted at 248/sup 0/C for 22 hours to verify the reproducibility of the initial activity and selectivity results of run Fe22, but no catalyst samples were taken. Four phases of iron were identified in the catalyst, namely ..cap alpha..-Fe, magnetite (Fe/sub 3/O/sub 4/), and two forms of iron carbide. The Moessbauer parameters of these phases agree well with data in the literature of the Quarterly Report for October-December 1985. Some significant observations are as follows: First, the methane selectivity was high for the earlier times on stream, (32 mole% methane) for 0 to 7 hours on stream as compared to 27 mole% for 7 to 22 and 22 to 34 hours on stream. Second, the C/sub 2/-C/sub 7/ product distributions were quite similar for the three time intervals. The value of ..cap alpha.., as determined by the slope of the distribution of the C/sub 3/-C/sub 7/ products,more » increased only slightly over time, from a value of 0.62 from 0 to 7 hours to a value of 0.64 from 7 to 22 and 22 to 34 hours. Finally, the C/sub 8/-C/sub 14/ fraction increased significantly with time, reflecting the effect of the accumulation and eventual saturation of heavier hydrocarbon products in the reactor. 9 figs. 7« less


Evidence indicates that n-version development techniques are more reliable than producing one "good" version-and cost effective in the long run. The author concludes that diverse, independent channels used in parallel are significantly superior to even the current state of the art, especially in situations where cost of failure is high.


The rapid growth of online education across the nation is producing a challenge for many developmental education programs. For various reasons, perhaps primarily due to a reticence to create more hurdles for a population already facing many, developmental writing faculty and administrators are often reluctant to offer online (asynchronous) versions of traditional face-to-face developmental writing courses. Recognizing that reluctance, we do not know whether it is truly justified.Two main concerns faculty and administration often express about creating online versions of developmental courses are fears about retention and students' ability to handle the technology. However, a study by Jennings (2002) of the computer attitudes of developmental students concluded that developmental students "reported generally more positive attitudes toward computers than did nondevelopmental students" and speculated that this positive attitude "may enhance the probability for advancement into the mainstream college curricula" (p. 5).Saxon and Boylan (2003) emphasized the importance of "research on the impact of online and other distance learning methodologies for developmental education" (p. 3). Bailey (2002) also noted that "Most colleges are in the early stages of offering web-based courses..." and "have not yet systematically investigated students' reasons for dropping online courses" (p. 5). Morris (2001) researched factors that affect student retention in online writing courses, and emphasized that "in general literature (including education-specific literature) perceptions of attrition are fraught with vagueness and potentials for inadequate understanding." He stated further that "attrition in online classes frequently is reported to be higher than in matching face-to-face classes, but the data is mixed, derives from different and incompatible measuring methods, is contradictory, and suggests research difficulty because of multiple variables" (p. 5).In support of online instruction, the Michigan Community College Association (2004)-in cooperation with the Michigan Virtual University (MVU)-has created a virtual learning collaborative among the state's 28 community colleges, listing online courses and allowing students to take them at any Michigan community college while maintaining academic record and residency status at the home college. A Fall 2003 review of the online courses offered through MVU and subsequent visits to the college websites have indicated that, although 19 colleges (70% of those offering online writing) offered freshman writing online, only one listed developmental writing online.Before more colleges will be interested in offering developmental writing online, many instructors and administrators need to know whether it is as productive of desired student outcomes as traditional, face-to-face instruction. The researchers conducted the following study to help address these concerns.MethodologyDevelopmental Writing PlacementThis study involved an urban, Midwestern community college with 9,000 full-time-equivalent students. Several years ago, the college established basic skill "levels" as prerequisites for taking courses that lead to a degree or transfer. For both reading and writing, skill levels are established primarily through reviewing student scores on the College Board's ACCUPLACER(TM) Computerized Placement Tests (CPT; College Board for Educators, 2004); students with extremely low English language skills are tested with the Levels of English Proficiency (College Board for Educators, 2004). Students whose scores fall below the required cut-score range raise their skill levels primarily through taking developmental courses with "exit competencies." Currently, a CPT writing score of 65-85 (and a reading score of 59-77) would place a student in Lansing Community College's developmental Writing 117, and a student completing the course with a grade of 2.5 or higher (on a 4. …


ABSTRACT Pollution and consistent exposure to nitrogen dioxide are known as factors in respiratory illnesses, such as pneumonia and emphysema.. Therefore, careful air monitoring of public areas is necessary. A convenient and cost-effective method uses passive diffusion tubes. These tubes, treated with Triethanolamine or TEA - a nitrogen dioxide absorbent, were placed in a non-smoking environment, The Meadows School in Las Vegas, for a control and smoking environments, which consisted of several small, neighborhood casino bars also in the Las Vegas area. After the tubes absorbed nitrogen dioxide from the designated environment for a week's time, they were analyzed and then tested spectrophotometrically. The results indicated that the non-smoking environments had a nitrogen dioxide concentration of approximately 0.004–0.011 ppm, semi-smoking areas (the dining area of the pubs) had a nitrogen dioxide concentration of 0.012–0.029 ppm and the most smoky areas (the bar area of the pubs) had a nitrogen dioxide concentration of 0.023–0.048 ppm. This assay suggests that the amount of nitrogen dioxide present is directly correlated with the concentration of cigarette smoke in a given area.


A 56-year-old man presented to the emergency department with upper abdominal pain that suddenly occurred during dinner. A physical examination revealed right upper quadrant abdominal tenderness without muscle guarding or rebounding pain. Blood test results were within normal ranges. Contrast-enhanced abdominal computed tomography showed relatively high-attenuation intraperitoneal fluid collection with contrast extravasation of the upper right abdomen in the early arterial phase, which increased in subsequent phases, suggesting active omental bleeding (Fig. 1). Emergency angiography was performed for a definitive diagnosis and hemostasis. Celiac arteriography confirmed active bleeding from the periphery of the gastroduodenal artery. Selective angiography of the gastroduodenal artery with a microcatheter revealed bleeding from an omental branch originating from the right gastroepiploic artery. Embolization was performed with 25% N-butyl 2-cyanoacrylate–Lipiodol mixture (Fig. 2) and completed after confirming hemostasis and no morphological vascular abnormalities, such as aneurysms or arterial malformations. Although the patient went into temporary hemorrhagic shock during angiography, his vital signs stabilized after embolization. Because there was no history of trauma, neoplasms, or coagulopathy, the patient was diagnosed with idiopathic omental hemorrhage. No further bleeding was reported in the 22-month follow-up. Omental hemorrhage is a condition in which omental vessels rupture, causing bleeding in the abdominal cavity. There are various causes, including trauma, neoplasms, adhesions, omental torsion, aneurysm, vasculitis, and anticoagulation. Omental bleeding that develops without trauma or underlying disease is diagnosed as idiopathic omental hemorrhage, which has been reported in both the young and elderly and predominantly in men. Sudden onset abdominal pain occurs in all patients and is sometimes triggered by overeating. Emergency surgery is performed for the purpose of diagnosis and treatment in most cases; however, some cases have been diagnosed preoperatively. Main treatments include partial omentectomy or vessel ligation. In this case, contrast-enhanced multidetector-row computed tomography was useful for an accurate diagnosis and identifying the bleeding site, which enabled minimally invasive treatment, such as transcatheter arterial embolization. Idiopathic omental hemorrhage is an extremely rare condition that may be life-threatening. It needs to be considered as a cause of acute abdomen or unknown intra-abdominal bleeding during or after a meal.


A brief review of some of the arguments pointing towards the possibility of organic conductors of the form a-(BEDT-TTF)&J3g(SCN)4 (where M=K, T1 and Rb) being candidates for Frohlich superconductivity is given.


Much study has been devoted to the function of chemical alarm cues in predator-prey relationships in aquatic environments, but little is known about the production of these valuable sources of chemosensory information. Recent studies have demonstrated that donor (cue sender) condition may play an important role in the production of chemical alarm cues in juvenile convict cichlids (Archocentrus nigrofasciatus). In laboratory experiments, we conducted trials to test for the effect of donor body condition on the minimum behavioural response threshold and/or intensity of antipredator response to conspecific chemical alarm cues. Chemical alarm cue donors were sampled from high or low condition populations. Pairs of juvenile cichlids were exposed to the skin extracts of high condition versus low condition donors, across a range of relative concentrations (200, 100, 50, 25, and 12.5%), and a distilled water control. We found that cichlids exhibited overt antipredator behaviour beginning at a concentration of 25% for the high condition cue, while a minimum response threshold concentration of 50% was seen for low condition cue. The intensity of antipredator response was greater following exposure to the alarm cues of high condition stimulus versus low condition donors. Taken together, these findings suggest that the damage-released chemical alarm cues from high condition donors are qualitatively and quantitatively greater than those of low condition donors.


Background: Hypothyroidism is known to cause reversible cardiac dysfunction in humans. Thyroid hormone alters the cardiovascular hemodynamics. This study was performed to assess echocardiographic changes in untreated newly diagnosed primary hypothyroid states as such studies are scarce in our setting.Methods: This hospital based cross-sectional study was conducted among 71 patients with newly diagnosed primary hypothyroidism who presented to the medicine outpatient department, at Universal College of Medical Sciences and Teaching Hospital (UCMS-TH), Bhairahawa, Nepal from December 2018 to June 2020 after taking ethical clearance from institutional review committee (UCMS/IRC/212/18). Thyroid function test and echocardiography were carried out in patients under study. The data was analyzed with SPSS Version 16.Results: A total of 71 patients (52 females and 19 males) with primary hypothyroidism were enrolled for the study. Among these 58 cases were overt/clinical hypothyroidism, and 13 cases were subclinical hypothyroidism. Echocardiography was abnormal in 63.4% of cases with 43.7% showing diastolic dysfunction, 18.3% diastolic interventricular septal thickness abnormality, 8.5% diastolic left ventricular posterior wall thickness abnormality, and 8.4% pericardial effusion. Conclusion: Our study found diastolic dysfunction, diastolic interventricular septal thickness abnormality, diastolic left ventricular posterior wall thickness abnormality, and pericardial effusion as the common echocardiographic change in patients with newly diagnosed primary hypothyroidism. Therefore, our study highlights the need for cardiac evaluation of patients with primary hypothyroidism so that early intervention can be performed to improve the clinical outcome.


Papers are presented which were published as a result of a project involving the preparation of a topographical elevation contour map of Mars from all data sources available through 1969, as well as the observation of Mars by spectroscopic methods in 1971 to provide additional pressure data for topographic information. Topics of the papers include: the analysis of large-scale Martian topography variations - data preparation from earth based radar, earth based CO2 spectroscopy, and Mariners 6 and 7 CO2 spectroscopy; the analysis of water content in observed Martian white clouds; and Martian, lunar, and terrestrial crusts - a three-dimensional exercise in comparative geophysics.


This paper investigates Japanese banks' earnings management behavior under three distinct economic environments: (1) high-growth with asset price bubble economy (1985-1990); (2) stagnant growth with financial distress economy (1991-1996); and (3) severe recession with credit crunch economy (1997-1999). Using bank balance sheet information of 78 Japanese banks, we do not find that earnings management behavior by Japanese banks significantly differs across the three periods. Our results indicate that banks used security gains as a means to manage earnings throughout all three periods. We also find that banks used loan loss provisions to manage earnings; however, this behavior is only prevalent during two periods. Due to the fact that banks faced record-high non-performing loans during the latter severe recession period, banks on average may have been restrained from using loan loss provisions to smooth income and/or to replenish regulatory capital; instead, we detect that the Japanese banks lowered their lending.


In This study, the effect of different concentrations of Zataria multiflora Boiss. essential oil (0.00, 0.005,0.015,0.03%), temperatures (8&25° C) and storage time (up to 21 days) was evaluated in a food model system (Humburger). The correlation coefficient of different concentrations of zataria multiflora Boiss.essential oil with logarithm of the numbers of E.coli 0157:H7 was (-0.528 ). It was found that effect of different concentrations of essential oil on growth rate of E.coli 0157:H7 was statistically significant (p


Conceptualizing shareholder unrest as the aggregate scale and gravity of shareholder dissatisfaction with company practices, we examine the effects of two distinct types of shareholder unrest – wea...


This study was aimed to determine the frequency of fast foods consumption among consumer at Benghazi city, explore their health and nutritional knowledge concerning fast foods consumption and calculate their body mass index (BMI). Thus a study has been conducted amongst 400 participants attending fast foods restaurants, parks, and malls in Benghazi city. The main results indicated that, fast food consumers are mainly young, especially those under forty years of age, men were higher than women, and the predominant categories were students and employees. More than two third study sample consume fast foods on a daily basis. In addition, the most of participants were known or had some knowledge about the biochemical component, nutritive value, and calories in fast foods, also the diseases caused by excessive consumption of fast foods. The majority of participants were overweight and obese; the current study reveals a strong positive association between the frequency of fast foods consumption and increased body mass index.


The thermoelectric properties of the hot-pressed n-type Fe 0.98 Co 0.02 Si 2 and p-type Fe 0.92 Mn 0.08 Si 2 mechanically alloyed with Si and C powders have been investigated. It has been found that mechanical alloying (MA) even for a short period is very effective for forming the β-FeSi 2 phase from the mixture of the α-Fe 2 Si 5 and e-FeSi phases during hot-pressing at 1173 K for I h. Both of the hot-pressed n-type and p-type samples are composed of mostly the β-phase with a dispersion of a small amount of e-phase particles. The amount of the e-phase decreases with increasing amounts of (Si+C) addition. A lot of fine α-SiC particles around 20 nm form in the samples mechanically alloyed for 20 h and hot-pressed at 1173 K for 1 h. The addition of (Si+C) markedly increases the thermoelectric power of both n-type and p-type FeSi 2 and the thermoelectric power values are at a maximum at 3-4 mass%(Si + C) for both cases. The electrical resistivity increases with increasing amount of (Si + C) addition for both n-type and p-type FeSi 2 . The addition of (Si+C) markedly decreases the thermal conductivity of both n-type and p-type FeSi 2 due to the dispersion of fine α-SiC particles, which results in the marked increase in the figure of merit. The figure of merit values are maxima at 3-4 mass%(Si+C) for both n-type and p-type FeSi 2 .


Abstract Introduction The majority of patients with progressive chronic lymphocytic leukemia (CLL) will relapse after front-line treatment and will require salvage therapy. The addition of rituximab (R) to fludarabine (F) and cyclophosphamide (C) is associated with improved responses and relapse-free survival in untreated patients with CLL (Hallek et al, 2009) and patients with CLL in first relapse (Robak et al, 2008). We present an update of FCR in patients with relapsed or refractory CLL. Patients and Methods We administered FCR between November 1999 and 2008 to 284 patients with relapsed CLL. Patients received a combination of fludarabine 25 mg/m 2 day 1-3, cyclophosphamide 250 mg/m 2 day 1-3, and rituximab on day 1 at 375mg/m 2 for cycle 1, and 500 mg/m 2 for cycles 2 to 6. Patients were assessed for response by 1996 National Cancer Institute (NCI) Working Group response criteria and for time to failure of therapy (TTF) and overall survival (OS). We assessed standard pretreatment characteristics including response to prior therapy. Results Patients entered into the study had a median age of 60 years (31-84 years). Median number of prior treatments was 2 (range, 1-10). Responses included 86 patients with CR (31%), 41 nPR (15%), and 84 PR (30%); OR was 75%. Median OS is 46 months (95% CI, 41-54 months), and median TTF is 21 months (95% CI, 19-27 months). On multivariate analysis, the variables independently associated with longer TTF were younger age, higher platelets, lower lactate dehydrogenase (LDH) or serum creatinine, lower number of prior treatment, fludarabine sensitivity, and absence of chromosome 17 abnormalities on karyotype. Six full dose cycles of FCR were administered to 104 patients (36%). The most common hematologic toxicity was grade 3 and 4 neutropenia complicating 22% and 34% of treatment courses. Forty-six patients (16%) experienced one or more episodes of pneumonia or sepsis during or following treatment. Conclusion FCR is an effective regimen in patients with relapsed CLL. FCR should be considered as salvage therapy for patients in third relapse or less, not refractory to fludarabine or without chromosome 17 abnormalities or complex karyotype. Elderly patients (> 70 years) experienced more treatment-related toxicity and should be assessed for comorbidities prior to therapy.


Longdom Conferences has taken an initiative to felicitate attendees with awards to recognise, celebrate and encourage achievement in its various conferences and events. We salute and acknowledge attainment within an industry that is continuously evolving and re-drawing the boundaries of best practice.


Aspect affects soil frost depth by influencing the amount of solar radiation received at the ground or snow surface. Depending on the conditions, frost can be of equal depth on north and south slopes, deeper on north slopes, or deeper on south slopes. Data illustrate all three conditions


This paper discusses how a possible future technology, called the Limbot, can change the face of how society experiences loss and death by providing a replacement for loved ones or public figures after death. With advancement in surveillance and data gathering, It is possible in this future reality that a robotic doppelganger can be produced after a death.


Understanding the social significance of cattle for African pastoralists has been a concern of anthropologists at least since the publication of Herskovits' classic work (1926). Pastoral models commonly depict how cattle are used in socially prescribed ways that enforce both social hierarchies and solidarity. This sort of approach emphasises the value and use of livestock mostly with reference to bounded cultural systems. Although such culturally relativistic portrayals offer valuable insights into traditions and customs that continue to influence the economic behaviour of African pastoralists, such models ignore many of the constraints and opportunities that capitalist modernisation imposes on the traditional roles of cattle. The constraints result in contradictions about ideal behaviors due to the conflicts that they establish with long-standing, institutionalised spheres for action, while the opportunities open up new arenas for innovation and action.


This paper studies the treatment for chronic atrophic gastritis(CAG) from deficiency of stomach-yin in. It proposes nourishing and moistening stomach-yin,and that unblocking is tonifying. Also it discusses using tonifying yin and eliminating pathogen,formula modification based on syndrome variation,and resolving dampness in the treatment for the deficiency of stomach-yin. It provides some references for clinical treatment of CAG due to deficiency of stomach-yin. Besides,it emphasizes the importance of protecting stomach-yin in the treatment of CAG.


The paper discusses the basic concept,operating principle and safety standards of network database, analyzes the security threat of network database from network system layer,WEB server layer,database connections and management system,and discusses the various levels of security protection technology mentioned above.


This research attempted to explore the determinants of small and medium enterprises (SMEs) compliance behavior in paying zakat (alms). This study involved business owners (SMEs) in the city of Mataram as the population and 176 people as the sample. The data were collected through online survey instruments employing the purposive sampling method. The testing technique and data analysis utilized Structural Equation Modeling (SEM). Hence, the findings discovered that zakat literacy, Islamic egalitarianism, and moral norms influence the intention of SMEs owners to pay zakat. On the other hand, intention affects the owner's choice and compliance to pay zakat. This study is essential for zakat institutions to have a new strategy to encourage SMEs owners to pay zakat, considering the great potential in Indonesia. Distribution of zakat funds to asnaf (noun group of people worthy of receiving a Muslim tithe) fairly and equitably will attract more owners to pay their zakat through zakat institutions. Transparency and fairness in the distribution of zakat funds can increase the level of trust of SMEs owners in zakat institutions.


Synthetic pyrethroids(SPs)degrading microbial community JZ-1 was domesticated by selective culture.Degrading experiments showed the optimum degrading conditions were pH 7,30 ℃.JZ-1 degraded fenpaprothren,cyfluthrin and cypermethrin with a concentration of 100 mg·L-1 up to 53.27%,33.36%,41.39% in 15 days in optimum conditions,respectively.The nearly complete 16S rDNA were amplified from JZ-1 using bacterial universal primers 27F and 1492R.The restriction analysis was performed following separate digestion with enzyme Rsa I,Which showed there were six clusters in JZ-1,Which meaned there were plenty of degradation bacterial resources in JZ-1.The representative 16S DNA sequences of six clusters were sequenced,and showed that the major clusters were Rhodopseudomonas and Porphyromonadaceae bacterium,respectively.This study contributes to screen and apply SPs degrading organisms for SPs biodegradation.


Background: Stature is necessary for medical and nutritional assessment in the living individual. Also, in Physical Anthropology and Forensic Medicine, determination of stature is an important parameter for personal identification along with others such as age and race.

Objective: The objective of this study was to investigate the relationship between stature and foot and hand variables in both sexes through anthropometric and radiographic means. At the same time, prediction equations for estimating stature from foot and hand parameters were developed.

Materials and Methods: Measurements of body weight, stature, foot length and breadth as well as hand length and breadth were taken from 400 randomly selected students in Al Baha University aged 19–22 years (290 male and 110 female). Plain X-ray for foot and hand was done for a subsample to measure the length and breadth of the metatarsals and metacarpals, respectively. Derived variables (body mass index, foot index, and stature/foot and hand ratios) were calculated from the measured variables.

Results: Significant correlations were found between stature and many foot parameters. Low correlations were found between stature and hand parameters. Predictive regression equations were computed to estimate stature from foot and hand parameters.

Conclusion: Predictive equations were computed to estimate stature from foot and hand variables. This would be useful in cases where stature cannot be measured in the living subjects or in cases of stature prediction in Physical Anthropology and Forensic Medicine.


The stability of the incompressible attachment-line boundary layer is studied by solving a partial-differential eigenvalue problem. The basic flow near the leading edge is taken to be the swept Hiemenz flow which represents an exact solution of the Navier-Stokes (N-S) equations. Previous theoretical investigations considered a special class of two-dimensional disturbances in which the chordwise variation of disturbance velocities mimics the basic flow and renders a system of ordinary-differential equations of the Orr-Sommerfeld type. The solution of this sixth-order system by Hall, Malik & Poll (1984) showed that the two-dimensional disturbance is stable provided that the Reynolds number $\overline{R} < 583.1 $. In the present study, the restrictive assumptions on the disturbance field are relaxed to allow for more general solutions. Results of the present analysis indicate that unstable perturbations other than the special symmetric two-dimensional mode referred to above do exist in the attachment-line boundary layer provided $\overline{R} > 646 $. Both symmetric and antisymmetric two- and three-dimensional eigenmodes can be amplified. These unstable modes with the same spanwise wavenumber travel with almost identical phase speeds, but the eigenfunctions show very distinct features. Nevertheless, the symmetric two-dimensional mode always has the highest growth rate and dictates the instability. As far as the special two-dimensional mode is concerned, the present results are in complete agreement with previous investigations. One of the major advantages of the present approach is that it can be extended to study the stability of compressible attachment-line flows where no satisfactory simplified approaches are known to exist.


The perfonnance records of 377 pullets produced from 20 sires and 220 dams of a closed flock of White Leghorn (WLH) were utilized for the present study. Means, heritability estimates and genetic and phenotypic correlations were computed. The genetic and phenotypic covariances obtained from sire + dam components were utilized for the construction of selection indices. Four selection indices were constructed utilizing 20-wk body weight, age at sexual maturity and 90-day egg production. Comparisons were made based on correlation between index and aggregate genetic gain (rIH) and aggregate genetic gain (ΔH). The most efficient index was three-trait index incorporating 20-week body weight, ASM and 90-day egg production.


Previous studies have shown that speech perception can shift because of cognitive attitudes about the speaker, but little is known about affective attitudes in speech perception. In our study, we investigated how affective attitudes towards Asians relate to the perception of Asian-accented vowels by native Australian English listeners. Affective attitudes were assessed with an established scale from the social psychology literature adapted to our specific purpose. Vowel perception was assessed using a vowel categorization task. Results show that the degree of dislike towards Asians negatively correlates with listeners' accuracy in vowel categorization. The results also provide evidence that cognitive attitudes elicit affective attitudes, and suggest the appropriateness of using social psychological tools to explicitly evaluate the role of affective attitudes in speech perception.


SUMMARY Feed makes up c. 0·7 of total variable costs on Irish beef farms. A period of reduced growth (caused by nutritional restriction) followed by a period of accelerated growth (compensatory growth) can be used to take advantage of lower cost feedstuffs (grazed grass) during the grazing season. The Grange Dairy Beef Systems Model (GDBSM) was modified to capture more accurately the implications of compensatory growth and, thus, the energy demand of beef cattle was partitioned into energy required for maintenance and energy required for growth. For the current study, three production systems were evaluated where the male progeny of dairy cows were finished as steers at 24 (S24), 28 (S28) and 30 (S30) months of age. Three different live weight gains (RESLWG; 0·4, 0·6 and 0·8 kg/day), reflecting different levels of nutritional restriction, were simulated during the first winter feeding period (November–February) for S24 and during the second winter feeding period for S28 and S30. This allowed the effect of different live weight gains during a nutritional restriction period on farm profitability to be determined. Results indicated that for S24 the most profitable RESLWG was 0·6 kg/day. However, for S28 and S30 the most profitable systems were RESLWG of 0·4 kg/day. Financial performance of all systems was very sensitive to variation in beef carcass and calf prices but less sensitive to concentrate and fertilizer price variation. Furthermore, sensitivity analysis showed that the level of maintenance energy reduction and the duration of this reduction had a modest impact on results. The GDBSM is demonstrated as a quantitative framework for simulating compensatory growth and determining its effects on the profitability of dairy calf-to-beef production systems.


The movement for the urban commons in Southern Italian cities has been facing the increasing touristification of the historic centres, a process of value extraction built on the character of 'authenticity' and 'marginality' of the urban poor's living to the external gaze. In this resistance, activists encountered the law both as a counter-hegemonic tool exploited to assert their claims over the urban space and as a governmental technique deployed by the public administration to partially tame their political praxis into bureaucratic frameworks. The law has thus been used both to shelter the marginalised from the effects of touristification and as a means to govern urban space by extracting value from urban poverty. This analysis highlights how movements opposing the commodification of urban poverty could gain political strength from creatively exploiting legal tools, which would allow them to protect the interests of the poor and achieve wealth distribution. It also stresses how urban studies would benefit from integrating the perspective of critical legal studies that considers the law as a battleground for social conflict.


Ordinary Portland cement mortar was modified by addition of aqueous emulsion of silicon waterproofing agent incorporating alkoxyalkylsilane or modified alkoxyalkylsilane. Effects of aqueous emulsion of silicon waterproofing agent on cement setting time, mechanical strength and variation of waterproofing performance were studied in detail. Testing results indicated that addition of chemically modified alkoxyalkylsilane had little effects on cement mortar and greatly enhanced its waterproofing performance.


55 GAZA, Palestinian Territories—Between the shattered memories of the past and an unknown future lies a pile of rubble that is called home. Mohammed Khaderi, his wife Ebtesam and the 22 members of their family live here, in the heart of Gaza. Their house was targeted by Israeli field operations and all but leveled during the last incursion into the Gaza Strip—the 2008-2009 war. Ever since, the Khaderi family has lived beneath a makeshift tent attached to what remains. Until mid-2007, Mohammed and his brother worked in Israel as laborers, but both lost their jobs after the frontier between the two states closed in June 2007, after Hamas took control of the Gaza Strip and Israel tightened its blockade. In December 2008, Israel embarked on a series of air attacks against targets in Gaza where, it P•RTFOLIO


In an attempt to define mechanisms by which B-cell non-Hodgkin lymphoma (NHL) may escape rituximab immunotherapy, we developed several rituximab-resistant cell lines (RRCL) generated from the rituximab-sensitive cell lines (RSCL) Raji and RL. Rituximab resistance was associated with CD20 downregulation and upregulation of CD52 and the complement inhibitory proteins (CIPs) CD55 and CD59. No significant alemtuzumab-associated complement-mediated cell lysis (CMC) or antibody-dependent cellular cytotoxicity (ADCC) was demonstrated in RSCL. In contrast, in vitro exposure of RRCL to alemtuzumab resulted in a significant degree of CMC and ADCC. Of note, in vitro blocking of CD52 with anti-CD52 F(ab')2 fractions in RRCL improved rituximab-associated CMC as compared to unblocked RRCL. Our current data provides a basis for further evaluation of alemtuzumab-based clinical trials for patients with rituximab-resistant NHL.


There is a close relationship among economic development, technological innovation and standardization. For example, economic development provides an economic foundation for technological innovation, and technological innovation promotes economic development, and simultaneously technology standardization is the technical specifications. Only by understanding and handling the relationship properly among them can we promote technological innovation to realize rapid economic development. This article elaborates the content and interaction mechanism of the three aspects above, uses GDP, the patents accepted and the stock of standard as quantitative indicators, applies the VAR model of econometric methods in the empirical study, stands on the national level considering the overall economic level, analyzes the degree of their interaction and the time law, puts forward the key points that should be focused at different times, and provides a reference for the macro decision-making.


For nearly the entire post-World War II period, naval and air navigation relied primarily on ground-based radionavigation systems. However, the spontaneous development of satellite systems gradually led to their disappearance. They are currently used partly in air operations and marginally in maritime navigation in some areas around Asia, in Russia and in the Middle East. However, at the beginning of the 21st century, the threat of effective interference with satellite systems began to be raised, which led to an increased interest in restoring or upgrading ground-based systems as backup systems in the Western world. In this context, the approach of Russia is interesting, as it is associated with the vast majority of deliberate GPS interference. There are reports in the world literature that various ground-based radionavigation systems operating in Russia are still observed. The article analyses, on the basis of the few available sources, information on the ALFA system, about which the least is known, and there are many indications that it is ready for use. http://www.transnav.eu the International Journal on Marine Navigation and Safety of Sea Transportation Volume 15


A tele-operated micro-handling/machining system, which covers the micrometer to millimeter range, has been implemented and the hardware and the software construction is described. Using this system, human beings can virtually enter the micro-meter world and perform precise operations in a natural way. In particular, a multi-axis force information-to-auditory information transformation technique has been proposed and experimental results demonstrate the effectiveness of the proposed methods by applying two different conversion techniques, the appropriate technique depending on the compliance of the object which is being operated on.


Abstract This article by Stuart Stone, Librarian at the Radzinowicz Library at the Institute of Criminology at Cambridge, examines a selection of online information resources used by criminologists and compares their particular features and deficiencies. The author's involvement in training early career researchers, both in formal training sessions and one-to-one sessions, over a long period, allows for user responses and experiences of the resources to inform this examination.


Kuala Tungkal Ferry Port is a Ferry Port that serves inter-island crossings between provinces. The Kuala Tungkal Ferry Port is managed by the West Tanjung Jabung Regency Transportation Service. In the transportation system, security and safety are highly favored as a form of good service delivery. However, the loading of vehicles on ships operating at the Kuala Tungkal Ferry Port is not in accordance with the standards set out in the Regulation of the Minister of Transportation Number 115 of 2016 concerning Procedures for Transporting Vehicles on Ships and Regulation of the Minister of Transportation Number 30 of 2016 concerning Obligations to Bind Vehicles. On Crossing Transport Ships. This study aims to determine the existing conditions for the transportation of vehicles on the Satria Pratama Crossing Motor Ship in accordance with the Regulation of the Minister of Transportation Number 115 of 2016, implementing vehicle binding obligations according to Ministerial Regulation Number 30 of 2016 and evaluating the needs of vehicle binding officers needed to improve the transportation system. aboard the Satria Pratama Ferry Motor Ship. The research methodology used is observation, survey and documentation. Then to analyze this, it is guided by the Regulation of the Minister of Transportation Number 115 of 2016 and the Regulation of the Minister of Transportation Number 30 of 2016. The results of this study are that the existing condition of the procedure for transporting vehicles on the Satria Pratama Crossing Motor Ship is still not in accordance with the Regulation of the Minister of Transportation Number 115 of 2016, the obligation to tie up vehicles on the Satria Pratama Ferry Motor Vessel is still not in accordance with the Regulation of the Minister of Transportation Number 30 of 2016 and the need for an ideal vehicle binding officer is 2 vehicle binding officers.


Indonesia is a maritime country with the largest numbers of islands in the world which covering more than seventeen thousands islands. There are thousand tribes and ethnics with their cultures suppose to be enriching the diversity of Indonesia. However a series of riots happening in Indonesia including Aksi Bela Islam (ABI) recently challenging the unity in diversity of Indonesia. This present study tries to describe Aksi Bela Islam (ABI) (The Peace Action of Defend Islam) rally that run peacefully brings impacts on Indonesia economic sector as stable social and political condition will bring significant impact on Indonesia economic sector. The rally is a long journey of Indonesia of Muslim majority to seek justice as the Republic of Indonesia State Police seems not to be serious to handle the Islamic blasphemy case. Through the framing approach, it will be described how ABI brings impacts on the economic sector focusing on the study on the media perspectives. From the perspective of one leading economic magazines in Indonesia Bisnis Indonesia.The framing from the media evidently showed that the rallyfollowed by millions of Indonesian Muslims does not bring negative impacts on the economic sector of Indonesia sinceit run peacefully, well manage and safe so the market gives a positive response and appreciationto the action.


This paper summarizes the operational performance results of a grid-connected Building Integrated Photovoltaic (BIPV) system installed in Colombia (in Bogotá, at 4° 35′ latitude and 2.580 m altitude) after three years of monitoring. The supervision was carried out with a sophisticated monitoring system, designed and implemented by us using the virtual instrumentation concept. The data obtained allowed evaluating the general performance of the BIPVS system as well as the quality of the electric power generated by the PV plant. The results indicated that the power generated by the BIPV system fulfills the specifications demanded by National and International standards.


The utility model relates to a mattress capable of assembling and disassembling, which belongs to bed clothes, and is formed by a plurality of unit blocks which are mutually equipped with connecting devices. The unit blocks are designed in square shapes, rectangle shapes or equilateral triangle shapes, and can be designed into special shapes according to bed types and needs. The mattress has three types, namely a foaming type, a filling type and a spring type, which has the advantages of strong air permeability, sanitation, health care, freedom, comfort, excellent bearing and supporting properties, multiple uses and energy saving, and further has the behaviors of durability, beauty, comfort and heath care, and is suitable for households, hotels, hospitals, kindergartens and the like.


It gives a brief introduction of window structures in flameproof electrical products for coal mine and some explosion transmission examples.


Analytical model considering the effect by the expansion of the execution by the quicklime pile and estimated formula of lateral pressure were proposed in the last time.This time we set the coefficient of subgrade reaction newly this time for calculated value of the displacement which added displacement by the elasto-plasticity method and displacement by the expansion this time coincides with measured value, and we propose the rational design technique which reflects synthetically the effect of the execution by the quicklime.


Focus Area: Sustainable Business Practices A paradigm shift is underway in our healthcare system whereby traditionally allopathic medical centers are beginning to adopt non-allopathic modalities of healing into their practices. This phenomenon has influenced the widespread emergence of integrative healthcare centers throughout the country whereby multiple disciplines are housed under one institutional roof. There is much to be learned from these pioneering centers of collaborative practice, as their seasoned experience in assimilating systems of healing provides valuable insight into the intricacies of interprofessional team care and contributes to the prospect of new and improved healthcare models. This session presents key findings from a multiple case study whereby the following three US integrative centers serve as research participants to explore the inner dynamics of interprofessional collaborative care: Center for Continuum Health and Healing (CCHH) at Beth Israel Medical Center in New York, New York Integrative Medicine Center (IMC) at Yale-affiliated Griffin Hospital in Derby, Connecticut Northern Hawaii Community Hospital (NHCH) in Waimea, Hawaii Data for this study were collected over a total period of 6 months, and in-depth interviews served as the primary source of qualitative information. Drawing from practitioner and staff perspectives within each center, the analysis illuminates perceived value factors and core challenges of interprofessional collaborative care, as well as underscores standout facilitators and best practices supporting the sustainability of integrative practices with an emphasis on communication forums, internal culture, and architectural design. Although the meta-findings address key barriers to multidisciplinary collaboration, the merits of converging healing paradigms in clinical practice is highlighted and a fundamental "bending" towards successful integration is celebrated. The conclusion of the study fuels optimism that the collective effort unique to the integrative model might serve as a successful blueprint to replace our ailing approach to medicine.


With the developing of more side of the world culture, Du weiming emphasize the Group Critical Self\|consciousness of China Intellectual to push forward and modernize the conditional culture. Though ancient Intellectuals had this character, we need this character more in contemporary time. Du's opinion can contribute the self\|construction of contemporary intellectual but also have some defects.


Markov Chain models are often used to represent subsurface stratigraphy and to simulate likely representations of the subsurface. The data used are cores or boreholes. Rock types are classified into a finite set of states, and a state transition probability matrix is estimated for some vertical sampling interval, ∆z. The estimated transition probability matrix is sensitive to the ∆z used. No objective methods for selecting a ∆z are available. The underlying deposition process is continuous rather than discrete. Hence, information is lost by discretizing the sampling domain, irrespective of the ∆z used. The thrust of this paper is to develop a Markov Chain model of subsurface stratigraphy that explicitly considers layer thickness statistics, recognizes the continuous nature of the underlying deposition process and does not suffer from the problems associated with sample discretization. A finite set of rock types is considered, and a state transition intensity matrix is estimated from interpreted borehole stratigraphic sequences. A simulation strategy is developed using the transition intensity matrix to determine the state by state transitions, and by bootstrapping (sampling with replacement from the empirical distribution function) a layer thickness corresponding to the new state from the borehole data. Example applications are provided to demonstrate the utility of the method. Continuous Parameter Homogeneous Semi-Markov Model by Ali and Lall 2 Introduction Stratigraphy in a sedimentary basin is usually characterized from well logs. Well log information is often classified into distinct rock or rock types. The vertical and horizontal stratigraphic changes are generally of subtle nature and can be probabilistically formulated and simulated in terms of such data. The goal of such a simulation is mainly the understanding and prediction of the stratigraphic behavior in a sedimentary basin (Harbaugh, and Bonham-Carter, 1970). The simulated stratigraphy helps locate stratigraphic traps of hydrocarbon, and search of oil, gas, or water in delineating reservoirs. Two types of probabilistic models for analyzing subsurface stratigraphy from such data are possible. First, one may consider an estimate of the unconditional probability of observing a particular rock type at a given location in the subsurface. Indicator Kriging (Journel, 1989) and Kernel intensity and regression estimators (Ali and Lall, 1993) have been used for this purpose. These methods work with a binary or categorical data set corresponding to rock types or hydraulic conductivity thresholds. Such estimates of the probability of occurrence of a rock type are useful for assessing the spatial variability of rock parameters over the site. However, they do not explicitly consider persistence in the occurrence of a particular type of rock, or the tendency of a certain rock type to follow another, e.g., coal seams commonly follow a seat-earth, and channel-conglomerates may be succeeded by point-bar sandstones (Miall, 1973). A Markov Chain (MC) approach is often used (Anderson and Goodman, 1957, Krumbein, 1968, Harbaugh, and Bonham-Carter, 1970, Bayer, 1985, and Sinvhal and Sinvhal, 1992) to assess the conditional probability of occurrence of different rock types through a one step state transition probability matrix. The utility of such an approach is to identify some genetic behaviors of the depositional process and generate synthetic stratigraphic profiles that possess such behaviors. Generating such profiles is useful for the understanding and prediction of the stratigraphic behavior in a sedimentary basin. Subsurface modelers may use such profiles for oil traps detection; and oil, gas, or water search in delineating reservoirs. Simulated stratigraphy also improves the understanding of flow behavior in stratified environments. Continuous Parameter Homogeneous Semi-Markov Model by Ali and Lall 3 Typically, MC models are applied for transitions along the depositional sequence, i.e, in the vertical. Transitions across states are usually considered across fixed stages or steps using a vertical sampling, ∆z, that is prescribed by the investigator. An appropriate ∆z depends on the scale of stratigraphic fluctuation, i.e., how rapidly rock types change in the vertical, and on the resolution of the borehole. A large ∆z relative to the scale of fluctuation leads to loss of information about the depositional sequence. On the other hand, if ∆z is taken to be too small, the number of transitions out of a given rock type or states may be very few, leading to a loss of the dependence structure and hence, to transition probability estimates that are not directly representative of the underlying process scale. This is a classical problem associated with discretization of an underlying continuous process. Despite much research (e.g., Sinvhal and Sinhval, 1992, Miall, 1973, Krumbein, 1967, Carr et al., 1966), a consensus for the optimal choice of ∆z in a given setting has not emerged. An alternative to such an approach is to use semi-Markov models (Krumbein and Dacey 1969, Dacey and Krumbein, 1970, Schwarzacher, 1972) where transitions between rock types occur at discrete time intervals, but the deposition rate of a particular rock type during such an interval is allowed to vary randomly. A continuous space model for lithology results. Past efforts at applying such models have suffered from a need to discretize the sample while estimating model parameters and/or assumptions of the parametric form of the probability distribution of rock thickness for each episode of deposition. In this paper we present a methodology for estimating parameters of a Homogeneous Markov Chain model in the vertical in a manner that obviates the need for a priori discretization of the domain. Transition intensities (relative frequency of state transitions per unit length) rather than transition probabilities are estimated from the data. A simulation strategy using these estimated transition intensities and a resampling of layer thicknesses is also developed. This approach is best classified as a semi-Markov Chain model. Applications to a data set from India and to one from Continuous Parameter Homogeneous Semi-Markov Model by Ali and Lall 4 Utah are presented to demonstrate the utility of the continuous parameter approach. Background A brief review of Discrete and Continuous Parameter Markov Chain models as used for stratigraphic modeling is offered in this section. Discrete Parameter Homogeneous Markov Chains (DHMC) Markov Chain (MC) models have been used for subsurface modelling since the 1950's. The occurrence of lithologies is viewed as a stochastic process. The lithology is modeled as a random state variable which takes discrete values X(z) (rock types: 1, 2, 3 ) as deposition, z, progresses. The values of the random variable X are called the states of the MC, while the deposition axis z is called the parameter of the MC. If the random variable X is considered to occur at discrete points (sampled at a resolution ∆z) along the z, axis, the Chain is called a discrete parameter MC. On the other hand, if the random variable X is allowed to occur at any point, the chain is called a continuous parameter MC. The Markovian property is stated as: P{X(zi) = k | X(zj) = l, X(z1) = m ...} = P{X(zi) = k | X(zj) = l} (z1< zj < zi) (1) where: zi, zj are the depths at points i, and j respectively. This property indicates that our knowledge of the state at point j is enough to infer the state at point i. First order dependence is expressed in equation (1). Models with higher order dependence can be considered. In reality, the deposition process varies continuously with time, and hence, with depth. The deposition type, rate, and its persistence vary over the site. However, a first order, homogeneous MC with a discrete parameter space (DHMC) has usually been used for the representation of such a process. The model is prescribed through a state transition probability matrix (TPM). The TPM is a two dimensional matrix which summarizes the relative transition frequencies Continuous Parameter Homogeneous Semi-Markov Model by Ali and Lall 5 from one state to another (Figure 1.). The TPM is computed from a tally matrix. Given n states, or types of rocks, an element fkm (∆z) in the tally matrix is the total number of transitions from state k to state m at a prescribed sampling interval ∆z. An element in the corresponding TPM, pkm(zi, zi+1), is the transition probability from state k at zi to state m at zi+1, and is given as: p ( z)=f z)/ f z) km km km m 1 n ∆ ∆ ∆ ( ( = ∑ (2) where ∆z is the sample discretization, (zi+1zi). A problem associated with the TPM calculation is to define an appropriate sampling discretization, ∆z. The sampling discretization, ∆z, is assumed to represent a lithologic unit within which the deposition is of the same type. There are two ways to discretize the sampling domain: 1) using break points for rock types, and 2) using a fixed ∆z. In the first approach, a sedimentological unit is presumed to have a uniform lithological composition, and transitions are considered across lithologic boundaries. Each unit, regardless of its thickness, represents a step for the MC. The lithologic thickness is not used. This approach may only be valid if the sedimentological units are of nearly the same thickness. The second approach provides an arbitrary increase in the number of observations. An equal interval sampling provides information about the lithologic thickness but it may result in information loss for lithologic transition. Bayer (1985, p91) showed that the tally matrix at a prescribed ∆z is equal to the sum of two matrices. The first matrix tallies the transitions to other states and has diagonal elements of value zero; while the second one tallies the lithologic frequency with off diagonal elements of value zero. The corresponding probability matrices represent transition (conditional), and total (u


Close connection of cluster processes with increasing competitiveness of territories and states has been recently reinforcing the idea of promoting a special approach in modern theory and practice, called cluster policy, that influences the formation and development of clusters. Regional production clusters are built on the basis of the assets and resource base of the territory and include organizations and enterprises of various sectors of economy. The development of territorial clusters can play an important role in solving the problem of attracting investments to regions, since exactly clusters are able to generate innovative mechanisms of management. Cooperation and specialization of entities included in cluster provides them with opportunities to increase both competitiveness and efficiency of their activities and financial stability. Generally, regional cluster policy implies a set of direct, but mostly indirect, activities aimed at reducing barriers to the exchange of knowledge and ideas, as barriers prevent the establishment of effective links between various participants in the clustering process. The article describes the features and conditions of successful implementation of the cluster approach as a factor in increasing investment attractiveness at the regional level. Moreover, the perfect case in point is the experience of implementation of cluster initiatives in the Republic of Tatarstan.


I this article, I want to introduce you to Bitcoin, a topic that fascinates me almost as much as cryonics. Many Cryonics readers will have already heard of Bitcoin (certainly my first introductions to it were by members of the cryonics community), but in order to go on and talk about cryonics-specific uses for Bitcoin, I think it is important to give the actual technology a proper introduction, as well as a brief history of its creation and development. But perhaps most importantly, cryonicists have had important involvement in Bitcoin's inception and spread, and through the backward-looking lens of history, I believe this is a connection the cryonics community will be proud of. [At this point, I think it's important to make the following disclaimer: I own bitcoins, and am very optimistic about their future, both in value, and their potential as a highly positive disruption in the global financial system.]


Chimeric antigen receptor (CAR) T cells have demonstrated promising results for cancers in pre-clinical models and early phase trials. However, some groups have observed serious adverse events (SAEs) and toxicities attributable to the administration of CAR T cells, the most clinically significant being cytokine release syndrome (CRS). In addition, a recent case report described a patient who developed an anaphylaxis reaction to CAR T cells, ultimately attributed to receipt of multiple doses of cells. As there are a number of ongoing clinical trials at our institution utilizing CAR T cells to treat various hematologic and solid malignancies and several patients have received multiple doses, we performed a retrospective review to assess whether early or late infusion toxicities were observed with subsequent infusions. We identified 47 of over 200 patients who received more than one dose of CAR T cells between January 2009 and December 2014. We assessed patient characteristics including type of malignancy, disease status at the time of subsequent infusions, cell product (autologous vs. allogeneic), presence or absence of prior lymphodepletion, number of infusions, dosing schedule, and the relationship to development of CRS. Each characteristic was examined for any correlation to developing a SAE. There were no early adverse events within 24 hours of infusion aside from one patient who developed fever, without other signs suggestive of CRS. The majority of non-hematologic grade 3-4 AEs were electrolyte disturbances and elevated liver function tests. Only two grade 3-4 AE9s were deemed possibly attributed to CAR T cells (one of which was pain at a site of bony disease in a patient with neuroblastoma). 13/47 patients experienced SAEs, with 11 occurring after the 2nd infusion and 2 after the 3rd infusion. Cell doses ranged from 1 x 106 - 2 x 108 cells/m2, with 8 patients receiving an identical dose as first infusion, 2 a lower dose, and 3 a higher dose. The median time of SAE occurrence in relation to the infusion was 5 weeks, with the earliest occurring 16 days following the second infusion. We further categorized the SAEs into the following categories: thromboembolic, pulmonary, fever/systemic inflammatory response, and electrolyte disturbance. A single SAE was deemed possibly related to a CAR T cell-induced hyperinflammatory response, occurring 16 days after the second infusion. Of note, we did not observe events consistent with anaphylaxis or suggestive of acquired immune response, and we found no evidence of human anti-mouse IgG antibody formation. We also found no relation between cell dose, cell type, lymphodepletion status, or dosing schedule. We can therefore conclude that repeated CAR T cell infusions are well tolerated, and that the majority of grade 3 and 4 adverse events are hematologic and electrolyte abnormalities that resolve without intervention. Furthermore, the majority of SAEs reported after multiple CAR T cell infusions were unrelated to the infusion itself. However, further evaluation of a larger cohort is necessary to determine whether an association between the timing of repeated infusions and CRS and other SAEs exists. These findings and our continued evaluation of patients receiving multiple infusions will help us to ensure the safety of administering multiple doses of CAR T cells in the future. Disclosures Rooney:Celgene: Other: Collaborative research agreement; Cell Medica: Other: Licensing Agreement. Brenner:Cell Medica: Other: Licensing Agreement; Bluebird Bio: Equity Ownership, Membership on an entity9s Board of Directors or advisory committees; Celgene: Other: Collaborative Research Agreement. Heslop:Celgene: Other: Collaborative research agreement; Cell Medica: Other: Licensing Agreement.


Synchronous hardware design is facing significant challenges as we push for higher clock speeds and more complex chips. Aside from the incredible task of optimizing designs year after year, physical properties of circuits at the current scale and speed are becoming major roadblocks. For example, skew associated with high-fanout clock signals put a great burden the designer by increasing design time, transistor variability reduces the yield of chips at fabrication, and energy consumption at low process sizes and billions of transistors burdens the consumer (as well as the environment). Because of variability, designers must either slow chips by introducing large safety margins or contend with lower yields.


PURPOSE: A device for measuring a vertical distance and the size of a hole is provided to prevent damage due to the collision of a measurement object or a measurement using the weight balance. CONSTITUTION: A device for measuring a vertical distance and the size of a hole comprises first, second and third scales(140,150,160), a measurement holder, first and second measurement tips(170,180), and a vertical distance calculating unit(190). The vertical distance calculating unit receives and processes a signal corresponding to the movement distance of a stage unit from the first or third scales, when the first measurement tip contacts to three spots within a target measurement hole. The vertical distance calculating unit calculates the size of the hole and barycentric coordinates using the coordinate of three-point. The vertical distance calculating unit calculates the vertical distance of the hole using a central coordinate value of each hole.


yampires are figures of enduring popularity with readers. Vampire novels, films, television programs, and role-playing games are creating greater demands for materials on vampire myths. Librarians are being called upon to answer ques tions and recommend books on vampires more than ever because of the popularity of the television series Buffy the Vampire Slayer. Unfortunately, most of the best titles on the subject were pub lished more than twenty years ago and are not brought to the atten tion of librarians the way a new release is. Janet T. 0;Keefe, a pub lic librarian with almost twenty years of experience as a vampirol ogist, has contributed this guest column on developing a strong col lection on vampire myths. O'Keefe owns one of the best private collections of vampire books in the country. This column describes the best books on vam


As the key key of braked fforce orce coefficient automatic testing system, the the influence factors of the braked force coefficient are are very important. important. The influence influence factors of of braked force coefficient, including including the the testing speed, tire model, water water film thickness and the temperature of of road road surface etc. are studied and analyzed in this paper. paper. The water water film thickness thickness and the temperature of the road surface are influenced by the environments.. So the method and and impact formulation are put up by many researches and and experimentss. Finally, Finally, the correlation experiment be completed in the typical road. The results show that that the method method and formulation formulation are acceptable. acceptable.


Ab initio (RHF, MP2, CASSCF, and CASPT2) calculations have been performed for the electronic ground and lowest excited singlet states of phenol, the complexes of phenol with water and ammonia, and the corresponding cations. In agreement with recent experiments it is found that proton transfer is a barrierless process in the phenol−(H2O)3 and phenol−NH3 cations, whereas no proton transfer occurs in the phenol−H2O cation. Novel aspects of the reaction dynamics in the excited-state manifold of the neutral clusters are revealed by the calculations. Predissociation of the S1(ππ*) state by a low-lying 1πσ* state leads to a concerted electron and proton-transfer reaction from the chromophore to the solvent. The excited-state reaction is endothermic in phenol−H2O and phenol−(H2O)3 clusters but exothermic (though activated) in the phenol−NH3 complex. These results substantiate recent reinterpretations of spectroscopic and kinetic data on hydrogen-transfer reactions in phenol−ammonia clusters. The close relationshi...


The androgen receptor (AR) is uncommon among Nuclear receptor (NR) because of its intramolecular interaction(termed the N/C interaction) and thus coactivators can alternatively bind to surfaces in the AR amino terminal. The Mediator complex plays a key coregulatory role in steroid hormone dependent transcription and is chiefly targeted to NRs via the LxxLL‐containing MED1 subunit. However, the mechanisms by which AR recruits MED1 have remained unclear. Here we show that MED1 binds to a distinct AR amino‐terminal region termed transactivation unit‐1 (Tau‐1) via two newly discovered noncanonical α‐helical motifs of MED1. The two MED1 LxxLL motifs are not required for AR binding whereas loss of the intramolecular AR N/C interaction decreases MED1 binding. We further demonstrate that mitogen‐activated protein kinase phosphorylation of MED1 enhances the AR‐MED1 interaction in prostate cancer cells. In sum, our findings reveal a novel AR‐coactivator binding mechanism that may have clinical implications for AR activity in prostate cancer.


We review information-theoretic approaches to obtaining simple probabilistic representations for sequences of exchangeable random variables. Specifically, we examine information-theoretic proofs of finite versions of de Finetti's celebrated representation theorem. Such results state, in a quantitative manner, that the joint distribution of the first k of n > k exchangeable random variables is close to a mixture of product distributions. Closeness is measured in terms of the relative entropy and explicit bounds are typically provided. First we review a recent information-theoretic proof a finite de Finetti theorem for binary random variables, and then we give a different, new proof for the case of arbitrary finite alphabets. This second proof is nicely motivated by the Gibbs conditioning principle in connection with statistical mechanics, and it follows along an appealing sequence of steps. The technical estimates required for these steps are obtained via the method of types.A full version of this paper is available online as [23].