Background: Alzheimer disease is a progressive and irreversible disease that finally leads to death. It destroys cognitive skills and memory, and eventually, the patient cannot do the simplest things.
Objectives: Cholinesterases (ChEs) which has the capability to control cholinergic transmission would result in elevating acetylcholine levels in the brain, by inhibiting CHEs. Coumarins have been shown to exhibit the inhibitory effect of cholinesterase, where the aromatic component results in designing novel candidates that can inhibit Ab accumulation.
Methods: The condensation of aryl aldehydes and 4-hydroxycoumarin. Besides, we applied ZnO nanoparticles as an effective heterogeneous catalyst in [bmim]BF4 . To determine the inhibitory activity, we used a substrate, i.e., acetylthiocholine iodide, to assay the tested compounds. Moreover, we applied Ellman's assay.
Results: The present research is an in vitro work. It explores the possible binding mode of these compounds inside the Acetylcholinesterase (AChE) enzyme. Moreover, regarding the synthesized coumarin derivatives, we also performed docking and Molecular Dynamics (MD) simulation studies. The results indicate a satisfactory inhibitory activity for the assayed compounds against AChE with IC50 values from 0.100 to 0.02 µM. In this sense, the stability of protein-ligand complexes and the interaction of the compounds can be understood by performing a molecular docking with molecular dynamics simulation of 5000 ps in the solvent system for AChE.
Conclusion: Finally, it is worth mentioning that we also tested coumarin derivatives (L14 and L15), leading to potent and effective AChE inhibitors.


How students experience educational environments and the interconnections between their readiness, task experiences and their long-term desire to reengage with course content are critical questions for educators. Research postgraduate students (n=310) at a research- intensive university in Hong Kong, engaging in a 24-hour introductory teaching course, participated in this study. Learner readiness for the course was assessed as prior Domain interest, self-efficacy, and knowledge. Subsequently, students completed four formative assessments, reported their on-task interest in seven strategically chosen tasks and end-of- course Course and Domain interest. Longitudinal-SEM tested interconnections between readiness components, Task, Course and Domain interest. Initial self-efficacy beliefs for teaching predicted early Task interest, while Domain interest was a predictor of Task interest in explicitly practical task experiences. Strong interconnections between Task interest across the study were evident. Individual written and social (discussion) tasks presented strong contributions to future Course/Domain interest. Implications for theory and practice are discussed.


The plasma calcium and phosphate response to iv injection of PTH was studied in laying hens fed diets containing 2.26% or 5.00% calcium, both during periods of egg shell formation and when no egg was in the shell gland. Compared with results for mammals, the response was considerably larger, more rapid and more transient. With PTH injection at 0 min, plasma calcium (5.00% calcium diet only) and phosphate were significantly decreased at 5 min. This was followed by an increase in the concentration of both ions until a maximum was reached between 20 and 30 min. After 60 min, plasma levels of pullets fed the 2.26% calcium diet were again practically normal. The maximum plasma calcium and phosphate response for the 5.00% calcium diet was more than twice as large as for the 2.26% calcium diet, while the stage in the egg cycle had no effect on the response curves. During the period of hypercalcemia the increases in plasma calcium and phosphate were closely correlated (r = 0.733, p < 0.001), suggesting that the r...


3,5-Diarylidene-1-methyl-piperidin-4-one derived in situ from N-methylpiperidinone and benzaldehyde undergoes intermolecular [4 + 2] hetero-Diels–Alder reactions with 2,3-dihydrofuran in [bmim]BF4–H2O (1 : 1) to afford furopyranopyridine derivatives in high to quantitative yields. Heterodienes, 3,5-diaryldiene-1-methylpiperidin-4-one an electron deficient oxadiene added to 2,3-dihydrofuran an electron rich dienophile because of an inverse electron demand, yielding furopyranopyridines with a high atom economy.


The invention relates to a method for operating, particularly for maintaining, an internal combustion engine (100) having an engine (20) which has a hardware structure (10) comprising an engine control unit (2) and a maintenance unit (1), having an electronic engine identification module (3) and having an engine control program, particularly comprising a firmware FW and a functional engine application FSW, having the steps: providing a computer program product via a network (80) by means of which an engine identification and engine data can be loaded together and can be exchanged, wherein the computer program product is designed for exchanging, particularly uploading and/or downloading, a maintenance software module (60), by means of which the engine identification and the engine data can be compiled; loading the computer program product onto a non-volatile storage medium (30); coupling the non-volatile storage medium (30) to the maintenance unit (1) of the hardware structure (10) and executing the computer program product, exchanging the maintenance software module (60) between the non-volatile storage medium (30) and the maintenance unit (1); identifying the engine and compiling engine data by means of the maintenance software module (60) and a hardware component of the hardware structure (10).


In order to adapt to the development trend of informatization and intelligence of railway bridge operation and maintenance management, the integration of BIM Technology and large-span railway steel bridge operation and maintenance business becomes more and more urgent. Taking one special railway steel bridge as an example, the division levels of bridge structural parts, structural elements and specific components were defined, and the refined BIM model of bridge was established based on the demand of operation and maintenance. The knowledge base systems of component, defect, inspection and maintenance in bridge was formed. The three terminal BIM management system was developed, and the closed-loop management process of bridge inspection, maintenance and repair based on the BIM model was established. At the same time, the monitoring information could be integrated, which can provide the basis for the formation of bridge digital twins. The research results provide a firmly support for data-driven comprehensive evaluation and conditional maintenance of railway steel bridges.


A set P of elements a, b, c, in which is defined a binary relation " " having the properties (1) a?a for all aCP, (2) a?b and b?a imply a=b, (3) a?b, b_c imply a_c, will be called an ordered set. If for any pair of elements a, b CP one of the three relations a a, b and c > a, b implies c > a + b) and their greatest lower bound ab (an element such that ab a for all a CL is the unit of L. Two elements a and b such that ab = 0 are called ,-independent; if a+ b = 1, they are a-independent(3); and if they are both a-independent, and ,u-independent, they are


A discussion on the 'dumping' of agricultural products is meaningless without a proper definition of the concept. "The term 'dumping' is a very emotive word, and the most misunderstood one in international trade," says trade specialist Riaan de Lange.


Tests were conducted to make electroless plating solution of nickel by unform design.Its quality was assessed by composite index Z.The experimental data were processed by statistical software.Based on this,the effects of the factors on the pluting lifetime and velocity were studied.The composition of supplementary solution was determined with circular experiments.It was found that the supplemenlary quantity of lacate and hypophosphite had highest effects on the lifetime.Under loading 1.4dm2/L and supplementary lactate 3 mL/L·h and supplemartary hypophosphite:nickel=3.7∶1(mol),the period of utilization could be greatly extended.


We propose a general formalism which extends those used for the standard theory of electron transfer (ET) in chemistry but also becomes equivalent to it far from the inversion point. Our model yields different results essentially in the vicinity of the inversion point when the energy barrier for ET is small. In that regime, the electronic frequencies become of the order of the phonon frequencies and the process of electron tunnelling is nonadiabatic because it is strongly coupled to the phonons. The consequence of nonadiabaticity is that the effective electron dynamics becomes nonlinear and that there is energy dissipation through the phonon bath. Thermal fluctuations appears as a random force in the effective equation. We use this formalism for a careful investigation of the vicinity of the inversion point. We find that when the model parameters are finely tuned, ET between donor and acceptor becomes reversible. Then, large amplitude electronic oscillations, associated with large amplitude and collective phonon oscillations at the same frequency, are spontaneously generated. This system is a coherent electron–phonon oscillator (CEPO) which cannot be confused with a standard normal mode. The acceptor which does not capture the electron may play the role of a catalyst. Thus when the catalyst is finely tuned with the donor in order to form a CEPO, it may trigger an irreversible and ultrafast electron transfer at low temperature between the donor and an extra acceptor, while in the absence of a catalyst, ET cannot occur. Such a trimer system may be regulated by small perturbations and behaves as a molecular transistor. We illustrate this idea by explicit numerical simulations on trimer models of the type donor–catalyst–acceptor. We discuss the relevance of our approach for understanding the ultrafast electron transfer experimentally observed in biosystems such as the photosynthetic reaction centre.


High‐risk human papillomaviruses (HR HPV) cause nearly all cervical cancers and, in the United States, the majority of head and neck cancers (HNSCCs). NFX1‐123 is overexpressed in cervical cancers, and NFX1‐123 partners with the HR HPV type 16 E6 oncoprotein to affect multiple growth, differentiation, and immune response genes. However, neither the expression of NFX1‐123 nor the levels of these genes have been investigated in HPV positive (HPV+) or negative (HPV−) HNSCCs.


Objective: To explore the related factors of the first hospitalization in schizophrenia patients. Methods: A Logistic regression was used to anaysis the related factors. Results: The factors promoting early hospitalization of schizophrenia patients included understanding degree(OR: 4.762), BPRS total scores(OR: 3.259), medical conditions(OR: 1.906), economic status(OR: 1.795) and payment way of medical treatment(OR: 1.413). Conclusion: The popularity of mental health knowledge and the coverage of the medical insurance should be increased, hospital environment should be improved in order to promote early hospitalization of schizophrenia patients.


The core issues presented in this research stem from the actual Civic Education learning process which emphasizes more on the process of knowledge transfer than the process of strengthening and character building particularly students' civic disposition. The purpose of this research is to elaborate the efforts which have been done by the teachers in developing and strengthening Civic Disposition of the students in State Senior High School 1 Lobbo. The underlying theory used in the research is the notion that civic disposition is one of the important elements in civic education, and teachers have a significant role in the process of civic disposition strengthening through Civic learning at school. This research conducted by using the descriptive qualitative method and data collected from the interview, observation, and documentation. The result of the research underlines some important characteristics in the effort to strengthen student's civic disposition, such as the importance of different implementation of value-based learning model, diversity of implementation of value-based learning model, strengthening core values building, and strengthening the function of teachers as the role models through the dialogical and interactive process. Various implementation of value-based learning model can be done by reinforcing core values as preferences for both individuals and schools by providing interactive and dialogical learning experiences between students and students, students with teachers, and students with their environment. This study recommended that teachers strengthen in developing value-based learning models through practical activities in and out of the classroom. Keywords— civic disposition; value-based teaching and learning process; core values


Rehabilitation engineering plays an important role in designing various autonomous robots to provide better therapeutic exercise to disabled patients. Hence it is necessary to study human musculoskeletal system and also needs to be presented in scientific manner in order to describe and analyze the biomechanics of human body motion. This review focuses on lower appendicular musculoskeletal structure of human body to represent joints and links architectures; to identify muscle attachments and functions; and to illustrate muscle groups which are responsible for a particular joint movement. Firstly, human lower skeletal structure, linking systems, joint mechanisms, and their functions are described with a conceptual representation of joint architecture of human skeleton. This section also represents joints and limbs by comparing with mechanical systems. Characteristics of ligaments and their functions to construct skeletal joints are also discussed briefly in this part. Secondly, the study focuses on muscular system of human lower limbs where muscle structure, functions, roles in moving endoskeleton structure, and supporting mechanisms are presented elaborately. Thirdly, muscle groups are tabulated based on functions that provide mobility to different joints of lower limbs. Finally, for a particular movement action of lower extremity, muscles are also grouped and tabulated to have a better understanding on functions of individual muscle. Basically the study presents an overview of the structure of human lower limbs by characterizing and classifying skeletal and muscular systems.KEYWORDS:   Musculoskeletal system; Human lower limbs; Muscle groups; Joint motion; Biomechatronics; Rehabilitation.


In this paper we investigate the evolution of the stability domain for a two
degrees of freedom Hamiltonian system near a 1:3 resonance. In this way, it is proven that
the lost of stability takes place when the size of the stability domain goes to zero. In fact,
away of the 1:3 resonance, there always exists a stability domain which size diminishes
as we approach the exact value of the resonance


Based on the requirement of welding technique in initiating explosive device sealing,the laser welding technique was proposed and its characteristics were analyzed.Examples of application of laser welding in initiating explosive device were given,the effect of laser welding and electron beam welding were compared,and application prospects and existent problems were analyzed.It indicated that the application of laser welding could raise the sealing performance of initiating explosive device,and would be used widely.


An analytical procedure to certify secret randomness, occurring when measurement outcomes are non-locally correlated, is developed for networks consisting of three or more parties.


A new type of "Cellular Turing Acceptor" is here presented. Some of its applications for feature extraction from chain-codes are also reported.


Objective To evaluate the left ventricular systolic synchrony in hemodialysis depended(HD)patients by tissue synchronization imaging(TSI).Methods GE Vivid 7 ultrasound system with TSI and Q-analyze software was performed in 70 HD patients and 35 control individuals.According to the left ventricular enddiastolic diameter(LVDd),HD patients were divided into left ventricular enlarged group(HD1,LVDd>55 mm)and non-left ventricular enlarged group(HD2,LVDd≤50 mm).Systolic asynchrony was determined by measuring the time to peak systolic velocity of all 12 segments corrected by the heart rate(Tc).Results ①The mean Tc and the Tc of most segments were greater in both the HD1 and HD2 groups than in controls(both P<0.05).②The Tc was prolonged in 463(463/840)segments in HD group and left ventricular systolic asynchrony was detected in all patients(70/70).③The mean peak systolic velocity(PSV)and the PSV of most segments in HD group were lower than those in the control group(P<0.05).④Compared with HD2 group,Tc was increased and PSV was decreased in partial segments of HD1 group(P<0.05),but no significant differences in mean Tc and mean PSV were found between HDI and HD2 groups(P>0.05).Conclusions Left ventricular systolic synchronicity was impaired in hemodialysis depended patients.TSI was shown to be useful for the detection of myocardial abnormalities and asynchrony in such patients and provided reliable parameters for clinical therapy.

Key words:
Echocardiography; Renal dialysis; Ventricular function,left; Uremia,Tissue synchronization imaging


Motion planning is a largely solved problem for robot arms with joint state feedback, but remains an area of research for sensorless manipulators such as toy robot arms and heavy equipment such as excavators and cranes. A promising approach to this problem is deep learning, which employs a pre-trained convolutional neural network to identify manipulator links and estimate joint states from a monocular camera video feed. Whereas manual labeling of training image sets is tedious and non-transferable, a simulation environment can automatically generate labeled training image sets of any size. The issue is the gap between simulated and real-world images. This paper solves this problem by implementing a Generative Adversarial Network. The complete joint state estimation pipeline is implemented and tested in hardware experiments to validate our proposed approach.


Na+-doped ZnO thin films (Zn1-xNaxO, x=0-0.20) were prepared on Si<100> substrate by sol-gel method using zinc acetate and sodium carbonate as starting materials. The electrical properties, including the conducting type and the carrier concentration, as well as the optical properties of the so-obtained films were investigated by four-point probe van der Pauw method and photoluminescence (PL) spectroscopy. After doping Na+, the conductive type of ZnO films changed to p from n-type, indicating that Na+ can act as an acceptor to occupy the Zn2+ sites in ZnO lattice. The resistivity, Hall mobility, and the hole concentration of the film with x=0.10 were 75.7 Ω•cm, 2.1 cm2/V s and 2.955×1016/cm3, respectively. The PL results showed that there were a narrow near-band-edge (NBE) emission line and a broad deep-level (DL) emission for all the films with and without Na+ dopants. A slight blue-shift from about 383nm to 380nm of NBE line was observed for the films after doping Na+.


In order to finish excavation amount of 20 000 m3/month,the medium-length hole blasting was used in Jinshan Stone Quarry.Because the environment was complicated,the initiation plan of square drilling and side initiation were employed to check whether the blasting vibration and fly rocks were safe or not.The results show that the blasting vibration and fly rocks are well controlled,block rates are also controlled less than 2%,achieving the anticipated goal.


Thank you for reading social program administration the implementation of social policy. As you may know, people have look hundreds times for their chosen books like this social program administration the implementation of social policy, but end up in infectious downloads. Rather than reading a good book with a cup of tea in the afternoon, instead they cope with some harmful virus inside their laptop. social program administration the implementation of social policy is available in our book collection an online access to it is set as public so you can download it instantly. Our book servers hosts in multiple countries, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the social program administration the implementation of social policy is universally compatible with any devices to read.


The utility model discloses a profiled metal roofing board free end portion wind-resistant connecting piece, belongs to the technical field of metal buildings and aims at solving the technical problem of improving wind resistance of metal roofing board free ends. The profiled metal roofing board free end portion wind-resistant connecting piece is characterized in that a wind-resistant accessory is shaped like an inverted L, an upper end horizontal surface is fixedly connected with profiled metal roofing boards, and square holes used for being penetrated through by wind-resistant carrying poles are formed in a vertical edge of the wind-resistant accessory. Each wind-resistant carrying pole is Z-shaped, the end portion of one end of each wind-resistant carrying pole is provided with an anti-drop folded edge, and the other end of each wind-resistant carrying pole penetrates through one square hole in the wind-resistant accessory and is fixedly connected with a roofing frame. The width of the anti-drop folded edge is designed to be larger than that of the square holes so as to prevent the wind-resistant carrying poles from slipping down from the square holes after being inserted into the square holes. The profiled metal roofing board free end portion wind-resistant connecting piece has the advantages that the metal roofing board free ends are connected into a whole through the wind-resistant accessory, and therefore single block wind resistance is changed into overall wind resistance. The connection method that the wind-resistant carrying poles penetrate through the square holes of the wind-resistant accessory does not affect free expansion and contraction (expansion caused by heat and contraction caused by cold) of the roofing boards. The profiled metal roofing board free end portion wind-resistant connecting piece is simple and reasonable in structure, convenient to install, firm in connection and good in overall safety.


The focus of this paper is to present an architecture for the seamless integration of devices in Small and Medium Enterprises (SMEs). Our proposal intends to cover any device, regardless of manufacturer or technology level. In this scenario, small lot sizes and the fast adaptability of the production environment is more important than short cycle times. Moreover, the ability to incorporate new devices smoothly must be considered in order to reduce adaptation costs in an otherwise stablished production environment. This is the main difference of our approach when compared, for instance, to the European Union's Sixth Framework Programme (FP6) called SMErobot1. Control Architecture for Device Integration (CADI), although a much modest project, proposes a more flexible approach for transitioning an stablished production environment from a current technology level into a more flexible and automated environment, without the need for an overall adaptation of the work cell and the acquisition of all new equipment. This paper presents CADI's architecture in the form of its subsystems: the tag subsystem, the device proxy and the work cell controller.


Water vapor is an important kind of greenhouse gas in the atmosphere whose spatial distribution is extremely uneven and time variation is also very fast. It is not only the main driving force of weather and climate change, but also an important formation and evolution reason for disastrous weather, especially meso-small scale disastrous weather. Along with the development of GPS meteorology, people start to utilize ground-based GPS technology in order to effectively compensate for the defects of traditional detection technologies in space and time and obtain water vapor information with high-precision, high-capacity and high space-time resolution ratio through ground-based GPS water vapor monitoring network. This main content of this paper is to launch the development of ground-based GPS water vapor monitoring system; the purpose is to make this system fill in the blank of the application of GPS inversion water vapor technology in Sichuan and even the southwest areas of China, and also enhance the capacities of meteorological department on the forecasting and monitoring of meso-small scale disastrous weather, as well as promote the work of many related meteorological operations.


With the introduction of global energy interconnection, the UHV transmission lines become more and more important as the backbone of the global energy internet. With the continuous construction of the UHV project in recent years, new requirements have been put forward for the new requirement for speed and quality of UHV project. It is very important to ensure engineering inspection and test activities are carried out in an orderly and orderly manner. Supervise engineering inspection and test results can reflect engineering quality level and it is also an indispensable part of the construction of UHV.


Objective: The main objective of this paper is to determine the relationship between organizational cultures and psychological empowerment on organizational commitment among lecturers in Higher Education Institution (HEIs) of Borno State, Nigeria. Organizational culture in this study includes Adhocracy, Market, Hierarchy and Clan cultures. Methods: Correlational design was adopted using cross sectional approach in this study. Total samples of 417 lecturers were drawn through proportionate random sampling method from a total accessible population of 1287. Data was collected through administration of adapted and adopted instruments from previous researchers designed on 5 point Likert scale. The reliability of the instruments was determined through the pilot study data using Cronbach's alpha reliability coefficients which stands at not less than .93 for all the instruments. The Data was analyzed using Structural Equation Modeling (SEM) with AMOS graphics. Preliminary and subsequent assessments of model fits were conducted from CFA to measurement model which fell within the acceptable threshold, and indicates the data at hand fits the model ( (4994) = 7873.606, p=0.00, /df =1.577, GFI=0.702; TLI=0.901, CFI=0.906; IFI=0.907, RMSEA= 0.042). Results: Findings depict significant relationship exist between organizational commitment, psychological empowerment, hierarchy and clan cultures. Also there is significant relationship between adhocracy, market, hierarchy and clan cultures with psychological empowerment. Furthermore, psychological empowerment, hierarchy and clan cultures are predictors of organizational commitment in the HEIs examined. Conclusion: Enhancing organizational culture and psychological empowerment could be a potent mechanism for improving lecturers' organizational commitment in HEIs in Nigeria. Higher educational institutions play critical roles in realizing national socio economic and political aspirations, hence due attention should be given to the types of cultures within organizations that encourage lecturer' sense of psychological empowerment and subsequently their commitment to the organization in specific and education system in general.


(57) in the manufacture of a medicament for use in the activation of the summary soluble guanylate cyclase (guanylate cyclase), its formula


A method for manufacturing a thin film transistor is provided to control an amount of a metal catalyst and to minimize the amount of the metal catalyst remaining on a multi crystal silicon layer by using a capping layer controlling diffusion of the metal catalyst. An amorphous silicon layer(120) is formed on a substrate(100). A capping layer(123) is formed on the amorphous silicon layer. A metal catalyst(126) is deposited on the capping layer. The metal catalyst is diffused through the capping layer by performing a first thermal process on the substrate to be moved to an interface of the amorphous silicon layer. A second thermal process is performed on the substrate to crystallize the amorphous silicon layer into a multi crystal silicon layer by the diffused metal catalyst. The capping layer is removed. The multi crystal silicon layer is patterned to form a semiconductor layer. The semiconductor layer is doped with a p-type dopant. N-type impurities are implanted into the semiconductor layer where the p-type dopants are doped and a third thermal process is performed. The n-type impurities are implanted by 1*e11/cm^2 to 3*e15/cm^2.


— Histological observations in three cases of tooth root displacement to the maxillary sinus show that under certain conditions the root may be accepted by the tissues. General and local factors in the defenco mechanism and the existence or otherwise of periapical pathosis must be considered in determining the treatment.


To the Editor: Prior to the introduction of sickle cell-modifying therapies, 5%–10% of patients presented with acute stroke by 14 years old.1 National guidelines provide recommendations surrounding central nervous system (CNS) complications, emphasizing rapid assessment of neurologic deficits and early initiation of transfusion therapy if acute stroke is suspected.2,3 Nevertheless, altered mental status (AMS) is a symptom of other CNS events.4 Here, we present an unusual case of rhabdomyolysis presenting as AMS in a patient with sickle cell anemia (SCA). A 15-year-old male with hemoglobin SS presented to the emergency department with fever, emesis, diarrhea, and disorientation, unable to answer questions. The AMS resolved quickly, but he appeared unwell with diffuse tenderness of all extremities. Laboratory evaluation revealed baseline anemia (hemoglobin 9 g/dl) with an elevated creatinine (1.39 mg/dl) and indirect hyperbilirubinemia (10.8 mg/dl). Emergent computed tomography of the head was unremarkable. Due to concern for sepsis, antibiotics were initiated, along with fluid resuscitation (several isotonic boluses). Given his acute kidney injury (AKI) and diffusemyalgia, creatine kinase (CK) was obtained and was elevated (2454 U/L), prompting admission. Six hours later, his CK increased (6067 U/L) and he developed transaminitis (alanine transaminase [ALT] 22.5 U/L; aspartate transaminase [AST] 101 U/L). His urinalysis (2+ blood and <1 + urine RBCs) was felt to be consistent with myoglobinuria. His social and medical histories were unremarkable for potential causes of rhabdomyolysis including drug use or infections; he reported no recent athletics or strenuous activities. Drug toxicology screenwasnegative.Aside fromnonadherencewithhydroxyurea, his sickle cell history was noncontributory. In the setting of AKI and rhabdomyolysis, the patient was started on isotonic fluids at 1.5-times maintenance. Despite aggressive rehydration, hisCK,ALT, andAST remainedpersistently elevated (Figure 1).On hospital day 3, he developed mild hyperkalemia, hypophosphatemia, proteinuria, and decreased urine output concerning for oliguric renal failure. Furosemide was initiated, and sodium bicarbonate was added to his intravenous fluids. Magnetic resonance imaging of the brain and lower extremities were performed due to persistent lower extremityweakness. His brain was unremarkable, while soft tissue and muscle enhancements in his lower extremities were concerning for myositis. He remained persistently febrile despite broad-spectrum antibiotics and an extensive infectious workup (Table S1). To reduce his hemoglobin S (HbS) level, the patient received three simple blood transfusions, resulting in an HbS level of 50.4%per institutional guidelines for a non-CNSevent. His myalgias, weakness, fevers, and laboratory abnormalities all resolved by hospital day 17, thus he was discharged. Rhabdomyolysis is defined by a CK level five-times the upper limit of normal or>1000U/L.5 Inciting events for rhabdomyolysis are broad but include infection, muscle overexertion or trauma, medication side effects, metabolic conditions, and myopathies. Initial studies should include a serum CK level, metabolic panel with liver function, urinalysis, and a complete blood cell count. Of note, serum CK levels often rise 12 hours after the initial insult, peak at 2–5 days, and return to normal within 6–10 days.5 It is vital to monitor for signs of AKI and provide appropriate fluid management to decrease serum CK, as myoglobin byproducts are toxic to renal parenchyma.6 Rhabdomyolysis is important to consider in that its symptoms overlap with those in other sickle cell complications. Rhabdomyolysisrelated pain can mimic an acute vaso-occlusive pain event. Blood on a urine dip without RBCs on urinalysis may occur with myoglobinuria in rhabdomyolysis or with brisk intravascular hemolysis in SCA patients with baseline hemolysis. Lastly, AMS in SCA is often due to CNS events including stroke, migraines, and cerebral sinus venous thrombosis. While rhabdomyolysis is rare in patients with SCA, there is military literature identifying rhabdomyolysis in patients with sickle cell trait (SCT).7–9 Metabolic changes during exercise may promote HbS polymerization and red cell sickling; the resulting microvascular obstruction leads to muscle ischemia, and rhabdomyolysis.9 Therefore, patients with SCA may have a higher incidence of rhabdomyolysis at a similar level of exertion. The lack of rhabdomyolysis reported in SCA may represent either a true higher prevalence in SCT or a lower awareness of rhabdomyolysis in patients with SCA due to overlapping disease-related symptoms and complications. The primary management goal in rhabdomyolysis is to prevent and treat AKI by administering intravenous isotonic fluids with a fluid rate that maintains a urine output of at least 200–400 ml/h until plasma CK levels fall below 1000 U/L.5 Some studies suggest a benefit of administering bicarbonate and mannitol if CK >30,000 U/L.10 Diuretics should be considered in the event of volume overload. Lastly, clinicians should monitor for disseminated intravascular coagulation as a rare complication.11 Specific to patients with SCA, close monitoring for kidney injury is warranted due to the increased propensity of patients with SCA to developing acute and chronic kidney disease.12–14 Second, respiratory status shouldbemonitored closely during aggressivehydration for


The development of mobile technologies offers new opportunities for service providers to create more sophisticated and value added mobile services. These new mobile services can provide a way to deliver various kinds of information to the customers or to work as an interaction channel between service provider and customer. This paper shortly summarized mobile technologies that can be used for creating mobile services for mCommerce. The paper also discuss about success factors for mobile services. Furthermore the paper introduces a case study of a mobile customer relationship management (CRM), that attempts devaluate proposed success factors


Here, we report the annotated, near-complete genome sequence of Allorhizobium vitis K377, a phytopathogenic Rhizobiales strain isolated from a grapevine in South Australia. The assembled genome sequence is 6.40 Mb long, with 5,855 predicted protein-coding sequences, 56 tRNAs, and 12 rRNAs, and contains ttuC (tartrate metabolism; chromosomal) and nopaline synthesis, uptake, and catabolic genes (tumor-inducing plasmid-encoded). ABSTRACT Here, we report the annotated, near-complete genome sequence of Allorhizobium vitis K377, a phytopathogenic Rhizobiales strain isolated from a grapevine in South Australia. The assembled genome sequence is 6.40 Mb long, with 5,855 predicted protein-coding sequences, 56 tRNAs, and 12 rRNAs, and contains ttuC (tartrate metabolism; chromosomal) and nopaline synthesis, uptake, and catabolic genes (tumor-inducing plasmid-encoded).


1. The current efficiency for the oxidation of cerous sulfate in sulfuric acid at a lead dioxide in an undivided cell was generally found to be 70%. 2. By using a paste of cerous sulfate in sulfuric acid, ceric sulfate reagent is obtained in a concentrated form. 3. A kinetic study of the oxidation of p-xylene by ceric sulfate is described and apparent energy of activation is calculated. 4. The process of oxidation of p-xylene to p-tolualdehyde is made cyclic and continuous by regeneration of ceric sulfate at a lead dioxide anode.


Reducing the execution time of program is a main goal of parallel processing ,while an efficient task allocation algorithm is a crucial step,especially on NOWs. A sub\|optimal algorithm OPTA on allocating a single task cluster to physical processors is presented in the paper here, and this task cluster is a common parallel paradigm in most parallel programming languages.An experiment of comparing with algorithm MH is made, and the results show that algorithm OPTA cuts 10% cost.


Recently it was shown by Hanasoge, Duvall, and DeRosa (2010) that the upper limit to convective flows for spherical harmonic degrees l<? is considerably smaller than the flows predicted by the ASH simulations (Miesch et a7. ref) at the depth r/R=0.95 ' The deep-focusing Lime-distance technique used to develop the upper limit was applied to linear acoustic simulations of a solar interior perturbed by convective flows in order to calibrate the technique. This technique has been applied to other depths in the convection zone and the results will be presented. The deep-focusing technique has considerable sensitivity to the flow ' signals at the desired subsurface location ' However, as shown by Birch {ref}, there is remaining much sensitivity to near-surface signals. Modifications to the technique using multiple bounce signals have been examined in a search for a more refined sensitivity, or kernel function. Initial results are encouraging and results will be presented'


when moving reference staff from behind the desk in the academic library and embedding them into campus departments and programmes both physically and virtually. Kokkinos, Papadatou and Sisamaki consider the use of marketing research methods for the evaluation of information literacy services, focusing on this new application for an existing research method. In contrast, Ross uses grounded analysis to investigate the use of a public library network by non-residents, with the aim of exploring the full use of the library network and 'how public library directors perceive the value of non-resident use for their libraries and communities'. Ross outlines the results of the completed research and identifies areas where further data needs to be gathered to fully answer the initial research questions. In addition to this volume being an important contemporary resource on researchmethods in libraries in its own right, it also serves to fuel interest in the possibilities of other library research and the following of or attendance at future iterations of the QQML Conference. Those with the most to gain from this volume are librarians and academics interested in the analysis and betterment of library service and functions, using qualitative and quantitative methodologies to provide the understanding and insight of how this can be achieved.


This paper discusses how people started generating profits through social media, showing some examples worldwide and in the Middle East and its effect on marketing. This paper aims to study the impact of social media on marketing from traditional marketing techniques to marketing on social media and its effect through people's daily information sharing and knowledge spread, moreover how individuals started gaining profits by being influencers and being followed by large number of followers without border limitations such as geographical location, language and age differences. This paper also conducts some studies about the cultural/political changes that are taking place through social media and how individuals started gaining money through these tools. Research hypothesis is that the world news , information and marketing spread to people is shifting towards social media and the influencers are effecting people's perceptions ,all of this is causing a tremendous change in people's minds , information sharing and communication flow moreover how people started generating money through social media tools..


Purpose – This study aims to carry out flutter stability and vibration analysis of a uniform hingeless rotor blade in hovering flight conditions.Design/methodology/approach – The perturbation equations are obtained using the governing differential equations of motion derived in Part I (Aircraft Engineering and Aerospace Technology, Vol. 79 No. 2, 2007). The differential transform method (DTM) is applied to the perturbation equations of motion and the transformed equations are coded in the computer package Mathematica.Findings – The effects of the built‐in pretwist angle and the rotational speed ratio on the natural frequencies are investigated and the results are compared with the results in literature.Originality/value – This study, in carrying out an analysis of flutter stability and vibration of a uniform hingless rotor blade, is in good agreement with previous studies in the literature.


The invention provides a concentrated non-aqueous cleaning solution having a long shelf life includes an ester and an anhydrous surfactant. The ester is the active ingredient for dissolving graffiti, grease and other contaminants. The ester can be one of or a mixture of dimethyl glutarate, dimethyl succinate, dimethyl adipate, ethyl lactate, and a methyl ester extracted from soybean oil. The anhydrous surfactant is preferably alcohol ethoxylate. The ester in the concentrated solution does not degrade into an acid and alcohol as long as the solution is not mixed with water. This allows the concentrated solution to be shipped and stored and remain efficacious. The concentrate can be diluted with water immediately prior to use. Diluting before use makes the graffiti cleaner less expensive and prevents damage to sensitive surfaces but does not provide long enough time for the ester to degrade.


Let A be an associative algebra over a field F of characteristic zero and let cn(A), n = 1, 2, . . . , be its sequence of codimensions. It is well known that the sequence of codimensions of a PI-algebra either grows exponentially or is polynomially bounded. In this note we are interested in the case of polynomial growth. For this case a celebrated theorem of Kemer characterizes the algebras whose sequence of codimensions is polynomially bounded as follows. Let G be the infinite dimensional Grassmann algebra over F and let UT2 be the algebra of 2 × 2 upper triangular matrices. Then cn(A), n = 1, 2, . . ., is polynomially bounded if and only if G, UT2 / ∈ var(A), where var(A) denotes the variety of algebras generated by A. In the setting of G-graded algebras, where G is a finite group, the sequence of graded codimensions is polynomially bounded if and only if var(A) does not contain a finite list of G-graded algebras. The list consists of group algebras of groups of order a prime number, the infinite dimensional Grassmann algebra and the algebra of 2×2 upper triangular matrices with suitable gradings. Such algebras generate the only varieties of G-graded algebras of almost polynomial growth, i.e., varieties of exponential growth such that any proper subvariety grows polynomially. In this note, we completely classify all subvarieties of the G-graded varieties of almost polynomial growth by giving a complete list of finite dimensional G-graded algebras generating them.


Wireless industrial communication systems are increasingly deployed for process automation and sensor/actuator networks with moderate requirements on latency and reliability. Many closed-loop control systems with more challenging latency and reliability requirements would benefit from wireless communication as well and have therefore become a research field of increasing interest in recent year. In the German research project ParSec novel concepts for deterministic and highly reliable wireless communication are developed. In this paper we discuss gateway concepts to enable seamless integration of such wireless communication systems into isochronous Industrial Ethernet systems with short cycle-times of 1 ms and below.


Until recently, varicella (chickenpox) was one of many prevalent infectious diseases that primarily affects children who inevitably suffered its unwanted health-related consequences. In early 1995, a then-new and well tested varicella vaccine (Varivax, Oka/Merck) was officially licensed for use in the United States. Varivax, however, remained unlicensed for use in Canada. In May 1999, Health Canada's Laborator y Centre for Disease Control (LCDC) held a conference to establish control strategies for possible use of Varivax in Canada. At that conference, a domestic cost-benefit analysis was designed and reviewed for proposed universal and routine varicella vaccination throughout Canada. The final recommendation resulting from this conference was that a universal immunization program for young Canadian children should be implemented within 2 years of availability of a refrigerator-stable vaccine. With the LCDC's recommendation and its potential implementation, the possibility of life without chickenpox could be envisioned. Or was it too good to be true? In January 1996, Varivax was added to the recommended standard childhood immunization schedule in the United States. In 1997, a comprehensive market survey of pediatricians in the US conducted by Merck found that only two thirds were incorporating the vaccine into the recommended immunization program. The Merck survey result begs the obvious question: why did one third of pediatricians decide not to use the vaccine?


An extreme-mass-ratio system composed by a white dwarf (WD) and a massive black hole can be observed by the low-frequency gravitational wave detectors like LISA. When the mass of black hole is around $10^4 \sim 10^5 M_\odot$, the WD will be disrupted by the tidal interaction at the final inspiralling stage. The event position and time of the tidal disruption of the WD can be accurately determined by the gravitational wave (GW) signals. Such position and time depend on the mass of black hole and especially on the density of WD. We present that by using LISA-like GW detectors, the mass-radius relation and then the equations of states of WDs can be constrained strictly (accuracy better than $0.1\%$). We also point out that LISA can accurately predict the disruption time of WD, and forecast the electromagnetic followup of this tidal disruption event.


Patients with coronary artery disease (CAD), heart failure (HF), or atrial fibrillation (AF) are at elevated risk for complications when they undergo noncardiac surgery. To find out how this risk varies by these conditions, researchers used three large Canadian administrative databases to construct cohorts of patients …


Abstraction has proven to be a powerful tool for controlling the combinatorics of a problemsolving search. It is also of critical importance for learning systems. In this article we present, and evaluate experimentally, a general abstraction method -- impasse-driven abstraction - which is able to provide necessary assistance to both problem solving and learning. It reduces the amount of time required to solve problems, and the time required to learn new rules. In addition, it results in the acquisition of rules that are more general than would have otherwise been learned.


Objective To analyze the relation between different syndromes and metabolic syndrome (MS) of overweight and obesity patients.Methods One hundred and twenty patients of overweight and obesity were divided into 4 syndrome groups with 30 cases in each group:Hot in the stomach,abundant phlegm-dampness syndrome,spleen deficiency,yang asthenia of spleen and kidney.The blood pressure,blood sugar,blood fat and MS of different syndrome were compared.Result Age,weight,waistline,blood pressure,blood sugar and glycerin trilaurate of each group tended to ascend,and high density lipoprotein cholesterol tended to descend.Blood pressure,blood sugar and glycerin trilaurate ascended obviously as the syndrome changing,with statistical significance (P0.05).MS morbidity ascended gradually and yang asthenia of spleen and kidney was the highest.Conclusion Blood pressure,blood sugar and glycerin trilaurate changed obviously in different syndromes,and they are intimate with yang asthenia syndrome of spleen and kidney,and MS morbidity is the highest in it.


The Last Glacial Maximum (LGM) in the Alps saw much of the mountains inundated by ice. Several main accumulation areas comprising local ice caps and plateau icefields fit into a picture of transection glaciers flowing into huge valley glaciers. In the north the valley glaciers covered long distances (hundreds of kilometers) to reach the forelands where they spread out in fan-shaped piedmont lobes tens of kilometers across, e.g. the Rhine glacier. In the south travel distances to the mountain front were often shorter, the pathway steeper. Nevertheless, not all glaciers even reached beyond the front, as the temperatures were notably warmer in the south. For example at Orta the glacier snout remained within the mountains. Where glaciers reached the forelands they stopped abruptly and the moraine amphitheaters were constructed, e.g. at Ivrea and Rivoli-Avigliana. Sets of stacked moraines built-up as glacier advance was directly confined by the older moraines.


The barefoot doctors are important groups being active in the history of rural primary medical and health services in PRC who have made a tremendous contribution to farmers' health at that time. The academic circle at home and abroad has conducted a certain research into this kind of group and formed a batch of research results. However, there are still lots of weak links. In order to deepen the research into this field, we need to do some innovation from such aspects as research content, research thinking and research angle of view.


Industry standard is related to the labour division of a nation in the international industry chain, is also concerned with a nation's essential benefit. In the information economy world,this issue is becoming more and more important. Standard can help improve competitive edge,reduce uncertainty and transaction cost. In China,the enterprises have no strong consciousness of standard, their ability of technical RD is too weak and they found themselves in a difficult position. The reason of these include that our standard policy follows convention,we have no profound understanding of the international rules concerning benefit and we have not enough investment. Through an analysis of its economic implication and China's awkward situation in this issue,this paper puts forward some political proposals including strengthening the planning of standard strategy,quickening the step to make control regulations,giving play to the roles of both government and trade union in establishing the standard.


The concept of statistical convergence was introduced by Stinhauss [1] in 1951. In this paper, we study con- vergence of double sequence spaces in 2-normed spaces and obtained a criteria for double sequences in 2-normed spaces to be statistically Cauchy sequence in 2-normed spaces.


The magnetic properties of graphene oxide have been investigated using spin-polarized density functional theory. A series of structures with an epoxy-pair chain at various positions on zigzag graphene nanoribbons is considered. The results show that this kind of graphene oxide is ferromagnetic at the ground state, providing great promise in the field of spintronics. In comparison with zigzag graphene nanoribbons of the same width, this graphene oxide is metallic and its spin density distribution is modified by epoxy pairs at different locations, thus rendering some fundamental insights into graphene-based materials.


The purpose of this paper is to establish necessary and sucient conditions for a point to be solution of a vector equilibrium problem with cone and ane constraints. Using a separation theorem, which involves the quasi-interior of a convex set, we obtain optimality conditions for solutions of the vector equilibrium problem. Then, the main result is applied to vector optimization problems with cone and ane constraints and to duality theory.


Simulation of future climate‐composition changes requires simulations of coupled dynamical‐radiative‐chemical models of many decades in length. Yet, to assure the generality of the simulation's results against uncertainties in emissions, unforced year‐to‐year variability and dependence on initial conditions, it is necessary to repeat them a significant number of times. The computational cost of such an exercise is still too large when using complex three‐dimensional coupled models.


Supplemental material, Study_Protocol_v3 for Attachment Orientations Guide the Transfer of Leadership Judgments: Culture Matters by Dritjon Gruda and Konstantinos Kafetsios in Personality and Social Psychology Bulletin


Exercise 1.2. Here is another definition of the trace and norm: pick a basis e1, . . . , en of the field F as a Q-vector space. Take α ∈ F . Consider multiplication by α as a Q-linear transformation on F (as a Q-vector space). Then this linear transformation with respect to the chosen basis e1, . . . , en is given by an n× n-matrix with coefficients in Q we define TrF/Q(α) = trace(A), Nm ′ F/Q(α) = det(A).


*SUMMARY Motivation: LTR retrotransposons are the common class of transposable elements found in plant genomes. They can comprise a huge fraction of certain genomes and may play important roles in genome organization and maintenance of genome fitness. Phylogenetic analysis and distribution of LTR retrotransposons in the different plant taxa can give us insights not only into the co-evolution of LTR retrotransposons and hosts, but also indicate some perspectives in retrotransposon research. Results: We investigated a distribution of Ty3/gypsy and Ty1/copia elements in 19 different species from 17 plant taxa. Totally, 169 clones with reverse transcriptase sequences were determined. LTR retrotransposons have been found for the species, in which no retroelements had been earlier described. That includes Bryophyta, Lycopodiophyta, Sciadopytiaceae, Nympheales, Winterales and Piperales in case of Ty1/copia elements; and Bryophyta, Lycopodiophyta, Filicophyta, Cycadophyta, Sciadopytiaceae, Nympheales, Winterales and Piperales in case of Ty3/gypsy elements. Several different families of both Ty3/gypsy and Ty1/copia elements were determined.


From the Bogor Botanic Garden, Bali Botanic Garden and Cibodas Botanic Garden in Indonesia, 293 medicinal plants were examined by photographing. From the Bogor Botanic Garden, 96 species in 50 families of plants were investigated. Among the medicinal plant region of this botanic garden, the most dominant family was Zingiberaceae with 12 species, followed by Acanthaceae with 7 species, Apocynaceae 5 species, Euphorbiaceae 5 species and Piperaceae 5 species. From Bali Botanic Garden, 185 species in 72 families of plants were studied. The most dominant families in the medicinal plant region of this botanic garden were Euphorbiaceae with 9 species and Zingiberaceae with 9 species, followed by Myrtaceae with 7 species and Malvaceae 5 species. From the Cibodas Botanic Garden, 12 species of medicinal plants were classsified.


Microbodies, a family of functionally diverse but morphologically similar organelles, are known under different names. The term microbody was first used by Rhodin to describe the small single membrane-bound vesicles in the proximal tubule cells of the mouse kidney.' In the Sixties, microbodies started to be characterized biochemically. Beevers' laboratory located the enzymes of the complete glyoxylate and /3-oxidation cycle in germinating plant seeds,' so demonstrating the metabolic importance of these glyoxysomes for the conversion of fatty acids to carbohydrates. In mammalian liver, De Duve and co-workers established the presence of an H,O,-producing and -degrading metabolism in microbodies for which they coined the name peroxi~omes.~ Since it turned out that an H,O,-metabolism can be found in almost all microbodies, the term peroxisome became a synonym for microbodies. Catalase is generally used as the marker enzyme for these organelles. However, it should be pointed out that there are also microbodies known which do not contain catalase, including the clycosomes of kinet~plast ida.~ In mammalian metabolism, peroxisomes were long believed to play only a minor role. This notion changed drastically when Lazarow ef al. discovered that peroxisomes of mammalian cells also possess a complete 8-oxidation p a t h ~ a y . ~ Moreover, in recent years it has become clear that these organelles perform a variety of anabolic and catalytic reactions.' The functional importance of peroxisomes was highlighted by the discovery of a number of inherited peroxisomal disorders in man, a class of autosomal recessive disorders which are often lethal during the first years of In cells from patients with these disorders, typical peroxisomes are absent although peroxisomal ghosts have been reported.' Extensively studied specialized metabolic processes in some yeasts, such as Hansenula polymorphu, Candida boidinii, Candida tropicalis and Yarrowia lipolytica, clearly demonstrated the remarkable variability of peroxisomal metabolism. These and other studies led to the current notion of peroxisomes (microbodies) as multipurpose organelle^.^ Their functions depend upon the organism, cell type, and environmental conditions. Thus, even in one organism they may show a considerable diversity in enzyme content and consequently can be involved in different processes. In this respect peroxisomes differ from most of the other organelles which are characterized by their distinct and conserved metabolism. A unique feature of peroxisomes is their inducibility, e.g. by hypolipidemic drugs.' Inducibility of peroxisomes as well as the hypothesis that defects in peroxisome assembly are the primary defects in some of the peroxisomal disorders greatly stimulated the interest in the biogenesis of peroxisomes.' In recent years a growing body of data related to this topic was reported. It appears that the gap of knowledge in comparison to other organelles becomes increasingly smaller. Consequently, peroxisomes are accepted and respected as bona jide members of the subcellular structures of eukaryotic cells. The series of reviews in this issue reflects some of the recent advances in physiology and biogenesis of peroxisomes in different organisms.


In order to improve the actual circumstance of traditional meter reading technology,this scheme utilizes direct connection between GPRS network and Internet,to implement realtime data acquisition and transfer.Its structure and operational principle are introduced in detail.It is characterized by higher speed,great data throughput,real-time performance and reliable communication.


The functional relationships of the ecological structure constituted by bacillus - matrix - plant and removing CODCr, TN and TP of the polluted river was probed. The results showed that the removal rate of TP by the combination of bacillus (imported to plant roots), limestone, Cyperus alternifolius and Iris pseudacorus was the highest and up to 79.85%; The removal rate of TN and CODCr by the combination of bacillus (immersed in the matrix), ceramsite, Ceratophyllum demersum and Iris pseudacorus were the highest and 65.36% and 62.21%, respectively. The removal of CODCr, TN and TP under bacillus immersed in a matrix or import around plant roots were significantly higher than the bacillus was put into water; Limestone for removal rate of TP was significantly higher than medical stone and ceramsite; The ceramsite for removal rate of TN was significantly higher than medical stone and limestone; The removal efficiency of the t CODCr, TN and TP of sewage by the configuration of Cyperus alternifolius and Iris pseudacorus were all the highest.


Abstract: VIP/PACAP are autocrine growth factors for lung cancer. VIP and/or PACAP mRNA is present in most lung cancer cell lines examined. Although mRNA for VPAC2‐R is not common, VPAC1‐R and PAC1‐R mRNA is present in many lung cancer cell lines. 125I‐VIP binds with high affinity to lung cancer cells and specific 125I‐VIP binding is inhibited with high affinity by (Lys15, Arg16, Leu27)VIP1–7 GRF8–27, the VPAC1‐R specific agonist, but not by Ro25–155318, the VPAC2‐R specific agonist. VIP elevates cAMP and increases c‐fos gene expression. The increase in cAMP and c‐fos mRNA caused by VIP is inhibited by SN(VH). (SH)VH inhibited the proliferation of NCI‐H1299 cells in the MTT assay, which is based on cytotoxicity. In a recent cell line screen, (SN)VH inhibited the growth of 51 of 56 cancer cell lines including leukemia, lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, breast cancer, and prostate cancer (T. Moody, unpublished). It remains to be determined if (SN)VH will be useful for treatment of a wide variety of cancers.


In recent years, full-time education experiences have reached national scope, gaining space in educational policies agendas, especially with the new Educational National Plano of 2014. At first sight, these orientations seems to indicate an increase in the right to education, as scholar time is extended, even in high school level. Nevertheless, this process needs to be analyzed more carefully. In this regard, this work aims to identify how access to full-time education has increased in the three basic education levels, in order to observe the development patterns for educational opportunities. The methodology used consisted in bibliographical review and descriptive statistical analyses, based on school census, in the period from 2010 to 2017. As a result, it was observed an increase in full-time education in all levels of education, however with very different paths, particularly in high school level.


A Research Project Report by Sharon .M. Ashanda, Submitted to the School of Business in Partial Fulfillment of the Requirement for the Degree of Masters in Business Administration (MBA).


Abstract : Various alloying additions have been discovered which render unalloyed chromium much less susceptible to low-temperature embrittlement as well as to nitridation in air at elevated temperatures. These include additions of the Group IIIA metals, magnesia, and carbides based on the Groups IVA and VA metals. Of these additions, only the carbides contribute significantly to the hot strengthening of chromium. The combination of selected carbides and solid-solution-strengthening elements such as tungsten, molybdenum, and/or tantalum, has resulted in experimental alloys which retain useful strengths at temperatures through 1316 C (2400 F). These high strengths are achieved at some sacrifice in the low-temperature ductility of chromium. Also, despite the improvements afforded in the oxidation and nitridation resistance of chromium through alloying, no alloys are available which are capable of service in long-time exposures in air above 982 C (1800 F) without suffering some property degradation.


A methodology for calculating eight spectral terrain characteristics by DEM is given. Their geomorphological meaning and mathematical definition are described. The generalized results of the spectral terrain characteristics calculation for five continents (except for Antarctica and a number of large and small islands and archipelagos) by DEM with a resolution of 1000 m, a step of a moving window of 10 km and its various sizes from 40 to 100 km are presented. The total covered area was 119.3 million sq. km. The results of the continents landform clustering on a small scale by its periodicity are shown – 10 clusters are distinguished using Kohonen neural networks and subsequent hierarchical clustering, which separate different patterns of topographic dissection. The spectral characteristics of the relief that distinguish various areas reflect the typical elevation difference between the watersheds and the bottoms of the valleys, their frequency in space, the unidirectional or multidirectional oscillations of the altitude field, and the prevailing direction itself, etc. Corresponding general map is made.


The NaLa(MoO_4)_2:Yb^3+/Er^3+ phosphor is synthesized through hydrothermal method with the further calcinations. The intense green upconversion (UC) emission is observed when it is excited by 980 nm pump power. Then we investigate the mechanism of UC emission based on the power dependent upconversion luminescence (UCL) spectra. Temperature sensing performance based on the Stark levels (^2H_11/2/^4S_3/2) of Er^3+ is estimated through investigating temperature-dependent UCL spectra from 298 K to 573 K. And the maximum value of sensor sensitivity based on FIR is approximately 0.00474 K^−1. Moreover, the variations of UCL intensities from ^2H_11/2/^4S_3/2 → ^4I_15/2 transitions have been monitored with increasing pump power, which suggests that the pump energy can be absorbed by sample and heat it. In addition, the internal temperature of materials can be estimated by FIR technique. All the experimental results indicate that the phosphor has good potential in optical temperature sensing and optical heating.


Context. Lambdapi is a new proof assistant based on a logical framework called the λΠ-calculus modulo rewriting, which is an extension of the simplytyped λ-calculus (the basis of functional programming languages like OCaml or Haskell) with dependent types (e.g. vectors and matrices of some given dimension) and an equivalence relation on types generated by user-de ned rewrite rules [1]. Thanks to rewriting, Lambdapi allows the formalization of proofs that cannot be done in other proof assistants (e.g. simplicial sets of in nite dimensions). However, for developing large proofs, it is essential to have a good interface. Interactive theorem proving is built on the mutual interaction between a human and a prover. The human will submit a candidate proof, and the proof assistant will con rm or reject the user proposal. Building large proofs is a very di cult task, and users do require large amount of help from the tools. Searching, completion, project management, are all essential to the successful development of large proofs.


Objective: To investigate the influence on the blood system by s human parvovirus B19 infection in pregnant women during early. Method: We identified 60 women who underwent early spontaneous abortion( observation group) and 60 health controls who elected assisted abortion( control group). The red blood cells,white blood cells and platelets were counted in each blood sample,the hemoglobin level was measured and the HPVB19- Ig M levels were determined by Enzyme linked immuno-sorbent test( ELISA). Method: In both the observation and the control group,women positive with HPVB19 Ig M had lower hemoglobin and red blood cell count than women who are negative of the virus( P 0. 05 for both). Among the HPVB19 + women,those in the observation group showed a higher anemia prevalence rate of 53. 85%( 7 /13),compared to the control group( 21. 28%,10 /47). The difference is statistically significant( P 0. 05). Conclusion: There is a strong association between HPV B19 infection and red blood cell count,suggesting a causal effect of the infection on anemia.


Summary form only given. Optically-excited terahertz (THz) radiation from unbiased semiconductors have been an important field of ultrafast optoelectronics since its discovery a few years ago. In this work, we report for the first time measurement of THz radiation from unbiased, as-implanted and post-annealed GaAs:As/sup +/ samples. The effect of thermal annealing time on depletion field, effective carrier mobility, as well as the peak THz radiating frequency of unbiased GaAs:As/sup +/ are investigated.


[Objective] To detect the expression of B7-2 and CD40 in allograft renal biopsies when rejection happened. [Methods] Allograft receptor′s renal biopsies were taken on pre-transplantation (at the cold ischaemia) and postoperative periods: 7 day, 1 month, 6 months, and 1 year after transplantation. The expressions of B7-2 and CD40 were detected with immuohistochemical methods. [Results] Renal biopsies 198 samples were obtained from 53 patients. The expression of B7-2 was only seen in endothelial cells and inflammation cells. Increased expression was observed in the tissue 7 day followed renal transplantation, and return to the lever of preoperative tissue after 1 month. The expression of B7-2 in cases of acute rejection (AR) significantly increased both than in preoperative tissue and in non-rejection groups. After 1 week anti-rejection therapy, the expression of B7-2 decreased to the level of preoperative tissue. No expression of B7-2 was detected in intercapillary cells, vascular endothelial cells and nephric tubule endothelial. No CD40 expression was deteced in preoperative renal, and only occasional CD40 expression insome cases of protocol renal biopies with nomal renal function. The expression of CD40 increased in case AR in endothelial cells, epithelial cells and inflammation cells, they were 21%, 39% and 60%, respectively; after anti-rejection therapy, the expression of CD40 was negative. The expression of CD40 in NO-AR groups was significantly lower than AR groups. [Conclusion] The expression of co-stimulatory molecules such as B7-2 and CD40 in grafts is correlated with clinical renal acute rejection.


While western Europeans have for some time been facing up to questions of complicity and collaboration with Nazi Germany, debates over collaboration in Eastern Europe have been far slower to surface. In part this had to do with the relative inaccessibility of archives and the hegemony of Soviet narratives of heroic communist resistance during the Cold War period. But in part it relates to the continuing significance of the Nazi past even in the post-1989 period. As the editors of this volume, Peter Black, Bela Rasky, and Marianne Windsperger, point out, with the collapse of communist rule, former anti-communist resistance activists were often celebrated as national heroes, overlooking the fact that many had been antisemitic fascists during the Nazi period. Moreover, the topic raises sensitive questions about far larger numbers of people. As Paul Schapiro points out in his opening remarks, 'bystanding' in face of collective violence is not neutral'.1 Commenting that


Phylogenetic systematic analyses of Anophryocephalus spp. resulted in a single most-parsimonious cladogram (consistency index: 80%). Cladograms for pinniped hosts (phocids and otariids) and Anophryocephalus spp. were highly incongruent, corroborating a hypothesis for colonization as a dominant determinant of parasite diversification. Phoca (Pusa) spp. in the Atlantic basin are postulated as the initial hosts; range expansion for hosts and parasites into the Pacific basin through the Arctic (ca. 3.0–2.5 million years ago) was followed by radiation of Anophryocephalus spp. among Phoca spp. and subsequent colonization of otariids (Eumetopias jubatus as typical hosts; ca. 2.0 million years ago). Host phylogeny and historical biogeography in conjunction with host distributions of these cestodes indicate evolution of Anophryocephalus was associated with dispersal and radiation of Phoca spp. in the Holarctic during the Late Pliocene and Pleistocene. Isolation in regional refugia and vicariance (during stadials) ...


Anticholinergic medications are used for a variety of reasons, from their effects on the central nervous system to their effects on the gastrointestinal tract. They are used in the treatment of Parkinson's disease, vertigo, gastroesophageal reflux disease, and peptic ulcer disease. They have also been used in the treatment of motion sickness. These medications must be used with caution due to their effects on other systems, including the central nervous system. Common central nervous system side effects due to anticholinergic medications include sedation, delirium, amnesia, and in the case of the patient presented in this report, psychosis. A 61-year-old man presented to the emergency department with visual and auditory hallucinations secondary to anticholinergic medications (scopolamine and atropine) he received in a smoking cessation clinic. Previous cases of anticholinergic medication–induced psychosis are also summarized.


This thesis is concerned with narrative constructions of women's identities in texts by contemporary Scottish and Irish women writers. I focus on texts by A. L. Kennedy, Liz Lochhead, Angela Bourke, Eilis Ni Dhubhne and Marina Carr. The theoretical framework of my analysis has been inspired by these writers' concerns with the relationship between narrative and reality. An important idea derived from the study of this relationship is that one's voice often, if not always, accommodates others' voices and is modulated by the power they convey. This power, derived from traditions that naturalise legitimate subjectivity constructs, steers and disciplines narrators, characters borne in these narrators' voices, as well as to whom they speak, readers or other characters, affecting the representations of the realities they inhabit. In my thesis, I examine literary explorations of the power through which narratives voices operate to constitute identities. The vision of voice as necessarily accommodating others' voices has suggested the use of Bakhtin's theories of heteroglossia in my analyses. The idea that an other's voice speaks in one's voice has sent me to Derrida's theory of citationality and to Judith Butler's theory of discursive reiteration and subjectivity. Regarding the act of narrating as an act of citation, I examine the role of narratives in shaping identity by providing subject positions derived form a citational chain of stories. The analysis of the relationship between narrative and reality undertaken in this thesis is interdisciplinary, involving elements of narratology theory, linguistics, philosophy, anthropology and social theory. The main argument can be summarised thus: myth is a manifestation of authority in the discursive acts through which we present ourselves to ourselves and to others in social reality. These discursive acts are to an extent acts of citation that reiterate subjective identities which, through this reiteration, have become naturalised, normative and constraining. The kind of subject they constitute is produced at the expense of alternative possibilities of cultural expression.


The complete general fundamental theory of the dynamical hypergraphs whose all mathematical structures are quantized, HoloQuantum Network Theory, is originally defined and formulated based upon a unique system of nine principles. HoloQuantum Networks are the quantum states of a (0+1) dimensional purely-information-theoretic quantum many body system, made of a complete set of the distinctively-interacting qubits of the absences-or-presences, which formulate the most complete unitary evolutions of the most general superpositions of the arbitrarily-structured hypergraphs. All the defining interactions and the complete total Hamiltonian of the quantum many body system of HoloQuantum Network Theory are uniquely obtained upon realizing the dynamical hypergraphical well-definedness by all the `cascade operators', the quantum-hypergraphical isomorphisms, the U(1) symmetry for the global-phase redundancies of the multi-qubit wavefunctions, the minimally broken symmetry of the qubits-equal-treatment, a Wheelerian maximal-randomness, and the `covariant completeness'. By the axiomatic definition and construction of the theory, HoloQuantum Networks are `all' the time-dependent purely-information-theoretic wavefunctions, and mixed states, of every in-principle-realizable quantum many body system of the arbitrarily-chosen quantum objects and their arbitrarily-chosen quantum relations. Being so, we propose HoloQuantuam Network Theory as the most-fundamental most-complete form-invariant `it-from-qubit' theory of `All Quantum Natures'.


The focus of the paper is on the long-term effects of the construction of a physical interconnection between SEE and Italy using a 1000-MW DC link from Italy to Albania. The impacts of this interconnection path are significant for the markets in Italy and SEE. The modeling issues are discussed and the simulation tool used to emulate the possible developments is presented. The use of scenario analysis is described and its ability to increase the realism of the simulations is discussed. We provide some representative results of the simulations. In addition, we discuss some key aspects of the cost-benefit analysis of the DC link. The extensive set of simulation studies indicate the gains in social welfare that may be realized as a result of the DC link. The financial viability of the transmission investment is considered from a private investor viewpoint taking into account the impacts of various sources of uncertainty.


In this paper, we make an attempt to predict the location of a cable in next frame according to some parameters in current frame. At first, the initial condition is that the approximate location of cable must be given. From Hough Transformation, a high accumulated degree point in Hough Space is gotten. Afterwards, by inverse Hough Transformation, using that point, the location is detected and then cable is pointed out from its original image. Based on actual working conditions and performance indices, as well as the location in current frame, the maximum range of degree within which the cable may occur in next frame with high possibility is evaluated. Furthermore, a narrow range of location in next frame is confirmed according to the speed of robot. It is this narrow range that reduces the influence of the background on the detected object to the least. Therefore, the location of cable can be detected more accurately. Still more, as the final target of this project, an approach to detect the dangerous status of Cable is shown. In this approach, we want to distinguish the predict area into three parts with a simple area partition. By means of time sequence, the relative changes on the size of area which is between shadow and cable can conclude whether the cable is suspended in water.


Theory posits that organizational design must be balanced. Previous literature has investigated the relationships between the three elementary design choices to understand how the balance is maintained. While management accounting choices are necessarily a part of the overall coordination mechanism, relatively little is known about the relationships between management accounting and organizational design choices. The aim of the dissertation is to generate some new insights in this area.


A white spored agaric growing in dense clumps from sclerotoid masses has been known to people in the University of California at Berkeley for approximately twenty-five years. Repeated attempts to identify it by means of the available literature failed, and, in the course of time, specimens were submitted to various specialists, namely, Doctors Jacob E. Lange, Carleton Rea, John Dearness and A. H. Smith. With one exception all reported the opinion that it is an undescribed species. Several collections of this same agaric have been made during recent years by A. H. Smith and H. E. Parks in northern California, and D. E. Stuntz and A. H. Smith in the region of Puget Sound, Washington. My study of this agaric has been greatly facilitated by the cooperation of the specialists mentioned above. Doctor Smith very kindly sent me his notes, specimens and photographs in order that I might compare the material collected in Washington and northern California with our collections from the San Francisco Bay region. Since all clearly apply to the one species under consideration, the following composite descriptions have been compiled:


Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Although this report is in the public domain, permission must be secured from the individual copyright owners to reproduce any copyrighted material contained within this report. Figures 1. Pressure-temperature phase diagram of a reservoir fluid highlighting the three types of reservoirs—oil (dissolved gas) reservoirs, retrograde condensate reservoirs, and gas reservoirs .. 2. Plot showing correlation between the condensate-gas ratio (BBL per MMSCF) and the ratio of well-reservoir-fluid gravity to separator-gas gravity for various combinations of condensate and gas gravities ..


Introduction Low-molecular-weight heparins are the standard treatment for cancer-associated thrombosis. Recently, direct oral anticoagulants are a new option for thrombosis treatment; however, data supporting the use of direct oral anticoagulants for cancer-associated thrombosis are limited. Objectives The primary objective of this study was to determine the rate of recurrent cancer-associated thrombosis and major bleeding within 6 months of starting either low-molecular-weight heparin or direct oral anticoagulant for treatment of cancer-associated thrombosis. Secondary objectives were to determine the rates of clinically relevant-non-major bleeding and all-cause mortality. Patients/methods This is a retrospective cohort study including adults with cancer-associated thrombosis treated with low-molecular-weight heparin or direct oral anticoagulant between 2010 and 2016 at the Ohio State University. Medical records were reviewed for 6 months after initiation of anticoagulation or until the occurrence of recurrent cancer-associated thrombosis, major bleeding, cessation of anticoagulation of interest, or death, whichever occurred first. Results Four hundred and eighty patients were included (290 low-molecular-weight heparin and 190 direct oral anticoagulant). Patients treated with direct oral anticoagulant were found to carry "lower risk" features including cancer with lower VTE risk and lower rate of metastatic disease. After adjustment for baseline differences, there was no significant difference in the rate of recurrent cancer-associated thrombosis (7.2% low-molecular-weight heparin vs 6.3% direct oral anticoagulant, p = 0.71) or major bleeding (7.6% low-molecular-weight heparin vs 2.6% direct oral anticoagulant, p = 0.08). Conclusions Our study demonstrates that in a select population of cancer patients with VTE, direct oral anticoagulant use can be as effective and safe compared to the standard therapy with low-molecular-weight heparin.


The battery, the battery system, the battery sub modules, wherein the battery operated, the battery system operating method, the battery-charging method, and a battery system charging method is disclosed. According to one aspect, the battery, the first battery terminal, the second battery terminals, respectively the first sub-module terminal, and the second sub-module terminal, the first and second sub-module, a plurality of rechargeable cells being electrically coupled between terminal for, and connection of one of the sub-module operating mode the first and second for connecting one of the battery terminals with a single electrically the first and second sub-module terminal of the sub-module and releases the operation mode of a sub-module the first and includes a plurality of sub-module and a switching circuit elements are formed so as to insulate the second one of the battery terminals as a single electrically of the first and second terminals of the sub-module sub-module.


We report the occurrence of a thermally induced, exothermic transition in Achilles' heel bovine tendon. The reaction is irreversible and bi-molecular. The activation energy is 0.28 × 10-14


IN RETROSPECT, the Winnipeg General Strike marked the beginning of a period of relative labour quiescence in Canada. Business fears of revolution proved groundless, as both union membership and strike activity decreased. Employers seemed to be enjoying the benefits of that spirit of co-operation between labour and capital which they invoked in earnest speeches and articles. • For business, however, labour-capital co-operation meant the achievement of four related goals. First, employers wanted to ensure that the labour power they purchased was converted into the productive and efficient labour that was the source of their profits. To this end, employers pursued a second goal gaining control over production and personnel decisions in the workplace, and maintaining that control in the face of attempts at resistance or regulation by individual workers, unions, and governments. Because of the perceived threat of government regulation, employers also sought a third goal, the establishment of business hegemony in the business realm. These three goals were summed up and extended in a fourth securing workers' consent o a class-based social order in the workplace and in the community. •


In this paper we present an analysis of the results of a study into wholesale (spot) electricity price forecasting with Support Vector Machines (SVM) utilising past price and demand data and Projected Assessment of System Adequacy (PASA) data. The forecasting accuracy was evaluated using Australian National Electricity Market (NEM), New South Wales regional data over the year 2002. The inclusion of PASA data shows little improvement in forecasting accuracy.


Ethanol sensors were made based on SnO_2/Si-NPA and the corresponding sensing properties were investigated. As-prepared tin dioxide sol was spin-coated on Si-NPA and then sintered in oxygen ambient, both for SnO_2 crystallization and strengthening the combination between tin dioxide and Si-NPA substrate. Silicon nanoporous pillar array (Si-NPA) is used as substrate which a novel silicon micron/nanometer structural composite system with both regular surface pillar array and porous structure, was prepared by hydrothermal etching method and its ethanol-sensing properties were measured. It was shown that SnO_2/Si-NPA exhibited high sensitivity and short response time to ethanol. This excellent performance of Si-NPA to ethanol was due to its surface structure and excellent gas sensing properties of SnO_2, i.e., the high sensitivity originated from the physical and chemical adsorption brought by the large specific area and SnO_2, while the short response time come from the effective gas transportation pathway provided by the regular pillar array. The unique hierarchical structure of SnO_2/Si-NPA might be applied in the field of silicon-based thin film sensors in future.


The invention provides an authentication method, a device and a system for aerial card writing. The method comprises that an aerial card writing terminal sends a card writing authentication request message to an aerial card writing server after the first time authentication of the aerial card writing terminal by the aerial card writing server is passed, when the aerial card writing terminal needs to conduct a card writing operation; the card writing authentication request message carries authentication information of a main smart card in the aerial card writing terminal; the aerial card writing server conducts a matching authentication to the authentication information of the main smart card in the aerial card writing terminal according to prestored authentication information and the received card writing authentication request message; and the aerial card writing terminal continues to conduct a subsequent card writing operation when the matching authentication result is that matching authentication is successful. Compared with the prior art, according to the authentication method, the device and the system for aerial card writing, the security authentication mechanism to the aerial card writing terminal from the aerial card writing server can be effectively improved.


This paper discusses the assessment of damage of protective structures based on the repairability criterion. The variables of the repairability are the amount of repair, repair cost, repair time, and resource availability. Their values were determined based on the assessment of the experts. These values are incorporated in the production rules and contained in the knowledge bases of a Fuzzy Reasoning Expert System (FRES). The modus ponens deduction technique is employed for partially matching the user's input to the production rules.


Viola odorata has been cultivated for cosmetics and medicine in Europe since antiquity. The spread by humans has expanded its distribution considerably beyond its original range in parts of the Mediterranean region, south-western Europe, and western Asia. One hundred and sixty-five plants of V. odorata from 52 collection sites from throughout most of its native range were analysed for seven isoenzyme systems. Twenty-eight allozymic markers were obtained, twenty-five of which were geographically variable. A profound east-west differentiation separating Anatolian and Caucasian populations from European populations was detected, with Greek and Sicilian populations somewhat intermediate. Western European populations were rather homogeneous, suggesting a common origin, which also included the Canarian var. maderensis and the naturalized Scandinavian (and British?) populations. Cretan and Cypriot populations were apparently recruited from more westward stations. The possibility that the two allozymic groups of V. odorata reflect isolated Pleistocene refugia is discussed. V. odorata appears to possess more geographically structured variation than has been found in other cultivated and human-spread species in southern Europe. © 2006 The Linnean Society of London, Botanical Journal of the Linnean Society, 2006, 151, 563-571.


Introduction: Acute appendicitis is the most common general surgical emergency. Appendicectomy is the treatment of choice for acute appendicitis and the most commonly performed emergency abdominal operation. Open appendectomy is found safe and effective operation with low morbidity but found to be associated with post operative pain, wound infection and complications like intestinal obstruction which may delay recovery. Laparoscopic appendectomy emerged as a good option for treatment of appendicitis. The purpose of this study was to compare the laparoscopic versus open approach among patients with appendicitis in our centre. Materials And Methods: This study was a prospective study of 100 patients with clinically diagnosed as appendicitis admitted in the department of General Surgery, Unit II, Zoram Medical College for a period of two years during November 2019 to October 2021. They were divided into two groups - Open Appendectomy (OA) group and Laparoscopic Appendectomy (LA) group of 50 patients each. Age ranges from 10yrs to 75yrs. Exclusion criteria were pregnant female, chronic medical problems, haemodynamically unstable or psychiatric illness, cirrhosis, coagulation disorders, patients on steroid, immuno-compromised patients, patients on chemotherapy for malignancy and those who are not willing to participate. OA was performed through standard Mc Burney incision. LA was performed through a standard 3 ports technique. Results: The most common presentation of appendicitis is abdominal pain followed by nausea/vomiting and common in younger age group of 10-20 years. Laparoscopic Appendectomy was found as safe and effective as Open Appendectomy. LA has more acceptable cosmetic result, shorter hospital stay and less postoperative pain. The pain score was significantly reduced in LA group (3.2+-1.4) and in OA (4.1+-1.8). Conclusion: LA was found as safe and effective as OA. LA has more acceptable cosmetic result, shorter hospital stay and less postoperative pain.


BACKGROUND
The long QT syndrome (LQTS) is an inherited arrhythmia syndrome with increased QT interval and risk of sudden death. Mutations in genes KCNQ1, KCNH2 and SCN5A account for 90% of cases with genotype determined, and genotyping is informative for genetic counseling and better disease management.

OBJECTIVE
Molecular investigation and computational analysis of gene variants of KCNQ1, KCNH2 and SCN5A associated with LQTS, in families with the disease.

METHODS
The coding regions of genes KCNQ1, KCNH2 and SCN5A in patients with LQTS and their family members were sequenced and analyzed using Geneious ProTM software.

RESULTS
Two families with clinical criteria for LQTS were investigated. The proband of Family A had QTC = 562 ms, Schwartz Score = 5.5. The genotyping identified the G1714A mutation in the KCNH2 gene. QTC = 521 ± 42 ms was observed in family members carrying the mutation against QTC = 391 ± 21 ms for non-carriers. The proband of Family B had QTc = 551 ms, Schwartz Score = 5.5. The genotyping identified the G1600T mutation, in the same gene. The analysis of family members revealed QTC = 497 ± 42 ms in mutation carriers, compared with QTC = 404 ± 29 ms in non-carriers.

CONCLUSION
Two gene variants previously associated with LQTS were found in two families clinically diagnosed with LQTS. The prolongation of the QT interval was observed in all family members carrying the mutations. A strategy was developed to identify variants of genes KCNQ1, KCNH2 and SCN5A, making it possible to train technical staff for future application to diagnosis routine.


Simultaneous estimation of unknown kinetic rate constant and heat of reaction is considered for on-line estimation of concentration in chemical reactors from thermal balance. A first-order reaction is studied to illustrate potential problems threatening this goal when the employed model seeks to estimate time-variant parameters. In particular, identifiability of the unknown parameters is lost when the model allows for time variations in these parameters, even though the true parameters in the process may remain constant. This unidentifiability rules out the popular technique of modeling parameter dynamics as a random walk in order to track time-variant parameters with an Extended Kalman Filter. A new strategy involving decoupled parameter estimation is shown to recover partial identifiability to the extent that when a true parameter settles at a new constant value, this value is estimated without bias. During the transition of the true parameter, the estimate shows bias; however, this bias is small for reasonable choices of the sampling period, allowing satisfactory tracking of slow drifts.


K l i f i The Invitation , the ceremony ,,f (he urivnlllrm of the ntatue of CMrlKl the KldK, recently donated to the I-oyola Howie i,f HctreittM, Monitstown, New Jerney, |» extended to iion-CuthollCH lid well an (,'uthoheK If. wiiti luinounccd ul. the Hclreul Iloniic todliy. 'the ceremony will hint not more thin, ",, hour, un weatliei limy i,,. ,,(,],i ,,,"] I,!,, only ntnmiliiK room, The Mniii.lu will be thrown open ioi public Ji npcelloii tilleeii mlmilei: uftei t.l. Clone of (he eKcrrli.fji. Isrfoie {luring Die i-xercli.el. If will be 11 nerved (in the clergy. Jn fipcukliii! to the rclrcnliniti, oyi-i I the lmil week end the Kev, II J fSloick, (I. J,, Director, dci.rrllicd the lifiitlle in, 111 il'iiII in ml ciililii|.. pi did iil.l.ciitlon Ut the liiet. unit lor the fIt'll), time In Ihi' history <,I int., un fur un can lie determined. fJhrliM. In portrayed stepping out of cloud;, wrought In bronze. The Kev, John Lnl"uigc, II. .(,, Annoclut.e |i;dl|.or of America, who Innpeeted the statue In the iil.udlo, iitiited: "It, given u powerlul, rapid, undlvlileil liiiplcnnlon of the King." The dove which In por. trayed idlghMni'. upon the r.houliler of (.'hrlnt dcniirnafcn the divine com. iiilnnlon ol (.'hrlnt, reculllng the Incident ol the Iliipflnin In the .lordan when the Holy (Ihonf In the form of a dove descended upon Chi'lnl. and a voice from heuven wun heurd nuylug: "Thin In my beloved non In whom I urn well pleased." Hcncuth the bronze eloudn on wlileh Ululnt In nliuullng In Die title: "(.'hrlntun Ilex.' Mr. Harry I.ewln Haul, ol Orange, N. .),, tlie nculpfor, In the New Jcriicy lltate (.'halriniui or the American Aitlntii I'l'ofennlon il I,cugue, und among hln wnrkn are numbered the ruggedly virile nl ul lie ol "America, 11)1711)111" ul. lOnglewood, N, ,).; hln "Fult.h Hope und .Charily" lor the Met.calf family; Iho ntatiie of Dr. Tridll (Irocn, ul Kiinton Cemetery; the BIHUIIMU-American War mon\unent, on the Northumpton County Court Holme Terrace. Hln "l.lncolii" wan recently delected to be placed on the new building of the Lincoln Triiiit Company and coiupuren with the "Lincoln' of IJarnard and Hulnt Cluuderw. Mr. Haul WUH born in 1'lunton, I'll. He In the recipient of ntimeroun nvt prize nm\ lit n noted lecturer In (sculptural clrcleii, (


Success in academia hinges on publishing in top tier journals. This requires innovative results. And this requires clear and convincing presentation of said results. Presentation can make the difference of one tier in journal level. A lot of useful advice on this topic is available online from well-respected outlets; see, for example, El-Omar (2014); Gould (2014); Neiles et al. (2015); Notz and Kafadar (2011); or Sachdeva (2020). This text provides a different angle.


A complex regional pain syndrome also known as Sudeck's syndrome is a chronic neurological disorder characterized by pain, edema, vasomotor instability, and motor weakness [1]. The Sudeck's syndrome may occur as a result of a fracture or other mild form of injury. Additionally, it occurs quite often in hand surgery, which makes post-traumatic and post-operative care even more diffi cult. There is no specifi c diagnostic test for Sudeck's syndrome. Diagnosis is usually based on medical history, clinical trial, additional studies and on the vigilance and experience of the attending physician [1, 5].