The study aims evaluate the prevalence of H. pylori in Population Basra city southern of Iraq including all age. Methods: During February to the December 2018 a study was carried out on 500 patients (male and female) they suffer from pain in the stomach and Abdominal and discomfort. The status of H. pylori infection was determined based on two different tests (serum anti H. pylori-antibody & H.pylori Ag rapid test –cassette (fecal specimen –CTK Company)). The serum test and rapid Ag test (stool sample) showed a significantly higher positive rate than expected, Of the 500 samples, randomized samples suffering from stomach and abdominal pain 290 were found positive, with a higher male incidence rate than females. The results showed 170 males with infected by bacteria H.pylori. "While" 120 females were infected. Prevalence of H. Pylori infection is high (58%) In people who suffer from pain in the stomach and Abdominal and discomfort. Infection is more common in adults and older people. The main causes of the increase in the: infection by H pylori.in the city of Basra is due to pollution of the city water and agricultural crops.


The elderly consume more labour-intensive services than young individuals. This makes them vulnerable to rising costs of services due to higher wages, which can be caused by increased capital accumulation. This paper shows that in a model with a service sector, the golden-rule capital stock is lower and dynamic inefficiency is more likely to occur than in the conventional one-sector model. This implies that in many cases, a positive Pay-As-You-Go tax maximises long-run welfare in a service economy. Calculations based on data from the United Kingdom and the Netherlands show that the long-run optimal degree of funding coincides with the current situation in these countries.


A real-time computer model has been developed to monitor Sea Surface Temperature (SST) focussing on specific latitude-longitude grids of interest. The model uses the daily binary file data from AQUA/AMSRE satellite sensors made available through website. The main purpose of the case studies is to explore and demonstrate possibility of any SST anomalies before, during and after the two great earthquakes of 26 December 2004 and 28 March 2005 that occurred near the western coast of Sumatra. The code is used to analyse and plot SST contour maps and time sequence of average SST deviations from the long-term means pertaining to grid sizes of 2° x 2° and 6° x 6° sea surface areas around the epicentres of these two earthquakes. The results indicate a small but significant warming of 0.2-0.3 °C in the 2° x 2° grid area starting a week earlier to a week later for the event date of 26 December 2004. Similarly the 28 March 2005 earthquake shows temporal changes in the mean SST anomalies but with reduced clarity due to limitation of data. Wavelet analysis brings out more details of the time sequence of the inherent power spectra. Such computer aided analysis and approach may be useful in other fields like El Nino induced monsoon rainfall, patterns of climate change, distribution of atmospheric pollutants and aerosols over oceans


This study applied functional magnetic resonance imaging (fMRI) to investigate the difference of the neural basis of Chinese chess players between grandmasters and first level players.The chess players are studied in the 1st National Mind Sports Games by using the method of fMRI.The result showed that increased activations were observed in cortical areas such as right precentral and postcentral cortex,left superior and middle frontal areas among grandmasters but in right occipital superior areas among first level players in comparison with each other.These results indicated that grandmasters may be of higher ability in logic reasoning,spatial working memory and motor control.


"Here are the literature references," wrote Bernard. "As you are being paid for the article my typist, who has looked up most of the authors and titles for you, says she will want her cut."


The Wulonggou Gold Field is one of the giant gold fields in the East Kunlun Orogenic Belt, northwestern China. Previous studies mainly focused on elementary mineral isotopic studies, fluid inclusions, and geological features in the Wulonggou Gold Field. In this study, we report some research on the precise age and the specific ore-forming process of the WGF: the hydrothermal monazite U–Pb ages; the way of gold precipitation; the composition, evolution, and source of ore-forming fluids of the Wulonggou Gold Field. Finally, we demonstrate a link between two-stage hydrothermal events and sequential episodes of crust-derived magmas, with implications for gold metallogeny in the East Kunlun Orogenic Belt. There are four hydrothermal stages that are recognized: a quartz–pyrite stage (stage 1), a quartz–pyrite–arsenopyrite–chalcopyrite stage (stage 2), a quartz–galena–sphalerite–pyrite stage (stage 3) and a quartz–stibnite–carbonate stage (stage 4). The monazite U–Pb ages of the Huanglonggou and Hongqigou deposits in the Wulonggou Gold Field were 422.2 ± 2.4 Ma and 236.7 ± 3.7 Ma, respectively, which support the opinion of two epochs of mineralization. Stages 1 and 2 are the main gold mineralization stages, wherein Au and As have a close genetic relationship. The Hongqigou and Huanglonggou deposits seem to have been formed in different metallogenic events due to the contrast on the trace element compositions in pyrite. The sources of the ore-forming materials and fluids of the Hongqigou and Huanglonggou deposits show apparent characteristics of orogenic gold deposit, and the magmatic events during Paleozoic and Mesozoic have an important contribution to the formation of the gold deposits. The gold deposits in the Wulonggou Gold Field can be interpreted as an orogenic gold system related to two-epoch tectonic–magmatic events.


As well-known, usually, in the asymptotic (Krylov-Bogoliubov-Mitropolski) method, the full amplitude (a) of the first harmonic is used as variable in asymptotic expansions [1]. In the first approximation, the equations of stationary oscillations are rather simple, however, in higher approximation, these equations often become very complicated, especially when initial conditions are imposed. In this article, a variant of the asymptotic procedure is presented and applied to determine stationary oscillations in weakly nonlinear autonomous system with given initial conditions. Instead of the full amplitude, the approximate amplitude of order c is used and by this, stationary oscillations can easily and successively be determined in each step of approximation, although various types of initial conditions may be imposed. It is interesting to note that the results obtained are identical with those given by the Poincare method [2] .


Weight function neural network is a new kind of neural network developed in recent years, which has many advantages, such as finding globe minima directly, good performance of generalization, extracting some useful information inherent in the problems and so on. Time complexity is an important measure of algorithm. This paper studies the complexity of neural network using second class orthogonal weight functions. The results indicate that the neural network has a linear relationship with the dimensions of input layer and output layer, an O (n3) relationship with the number of samples. Finally gives some simulation experiments for time complexity.


Piezoelectric materials can realize the mutual conversion of electrical energy and mechanical energy, and are widely used in electronic devices such as piezoelectric filters, micro-displacers, actuators, and sensors, which have crucial uses in the fields of information and communication, biomedicine, military defense, etc [...]


Junior doctors have limited experience in psychiatry before starting their training placements. The out‐of‐hours setting offers specific challenges, and trainees are expected to cope despite being underprepared. We hyphothesised that simulation‐based training would increase trainees' competence and confidence in approaching high‐risk out‐of‐hours scenarios.


We must reform the traditional teaching mothod of DENG Xiao-ping's theory to improve it.The reform methods are:system of teachers' competition,open teaching method,multiple links teaching,binary active system of teaching and learning,a bridge of equal communication,consciousness of questions,enforcement of students' ability of analyzing and solving problems.We highly improve the researching and teaching of DENG Xiao-ping's theory with these reforms. [


We report on the fabrication of carbon nanotube network field effect transistors, in which a submonolayer network is selectively and uniformly dispersed in the active region with individually addressable back gate. The high current on/off ratio (104) and good device-to-device uniformity were achieved by selective burnout of metallic pathways. The enhanced capacitive coupling between the gate and nanotube network reduces the subthreshold slope down to 180mV∕dec. The effective local gating allows us to implement logic circuits, such as an inverter and the two most important universal NOR and NAND gates.


By using an immunoperoxidase antibody method, mouse blastocysts were found to bind specifically hCG and ovine LH but not FSH or the beta unit of hCG. Brown peroxidase reaction products were present in the morula and increased with the formation of the blastocoele. The LH/hCG binding 'sites' may be related to the initiation of steroidogenesis in the embryo.


Recent ab initio studies showed that the inherent ductility of cubic structured Cr1−xAlxN coatings (as compared with similar hard coatings) significantly increases when alloyed with Ta. As there is only little experimental and theoretical information available, we have performed a combined experimental and ab initio based study on the influence of Ta additions (0, 2, 6, 12, and 26 at. % on the metal sublattice) on structure and mechanical properties of arc evaporated Cr1−x-yAlxTayN coatings with Al/(Cr + Al) ratios >0.61. With increasing Ta-content, the droplet number density decreases and the coating surface smoothens, which is much more pronounced as with increasing the bias potential from −40 to −120 V. Simultaneously, the columnar structure observed for Ta-free Cr0.37Al0.63N significantly changes into a fine-grained structure (crystallite size ∼5 nm) with clearly reduced columnar character. Increasing the Ta content also favors the formation of a preferred 200 growth orientation resulting in a reducti...


This paper brings forth the efforts made by investigators in the field of IC engines aimed to improve its fuel efficiency and reduce its emissions. It is observed that various techniques are in the process of research so as to reduce friction at the moving interfaces in IC engines for addressing the concerns. Recently, certain surface textures (patterning nano/micro/macro geometries on the surfaces) have been identified as a viable technology for reducing friction at the interfaces of various tribo-contacts. Surface textures are also being employed at piston rings/cylinder liner interfaces to investigate the reduction in friction and wear, and accordingly, develop the possibilities of fuel-saving and emission reductions in IC engines. Several numerical and experimental studies indenting to improve IC engines' performance using surface textures are available in the open literature. Therefore, this paper aims to compile the available information on the tribo-performances of the piston ring/cylinder liner contacts as well as fuel-saving and emission reductions of the IC engines employing the surface textures at one place for ready reference to readers.


Metals are non-biodegradable and recurrent in the environs. Heavy metals tolerant fungi were isolated from refuse dumpsite soil using pour plate method. These fungi were identified as Aspergillus niger, Penicillium chrysogenum and Rhizomucor sp. The fungal isolates were screened for cadmium (Cd), lead (Pb) and zinc (Zn) with concentration of 200ppm, 400ppm and 600ppm. Aspergillus niger and Penicillium chrysogenum showed high tolerance for the metals in contrast to the control. The fungi with high tolerance were used for biosorption study. However, Penicillium chrysogenum showed higher lead removal or biosorption potential of 1.07ppm, 3.35ppm and 4.19ppm as compared with Aspergillus niger with lead removal of 0.67ppm, 3.11ppm and 3.79ppm at 5, 10 and 15 day respectively. One-way Analysis of Variance was used to interpret the data generated from the biosorption study which revealed that there was no significant different (p > 0.05) between the lead removal of Aspergillus niger and Penicillium chrysogenum on the 5 day but there was significant difference (p < 0.05) in the lead removal of Aspergillus niger and Penicillium chrysogenum on the 10 and 15 day. This study suggests the use of these fungal isolates for removal and biotreatment of heavy metal contaminated and polluted environment.


State of the art survey and critical reviews of NACA and NASA report literature on design and construction of light aircraft structures


An electrolytic capacitor comprising a case and, accommodated therein, a capacitor element produced by winding a pair of counter electrodes with conductive separator (E), the conductive separator (E) on its surface provided with conductive polymer layer (F) containing dopant agent (H), interposed therebetween and impregnating the interstice of the electrode pair with an electrolyte for electrolytic capacitor. It is intended to suppress any increase of ESR with time passage in an electrolytic capacitor making use of the conductive separator (E) by the employment of, for example, an electrolyte for electrolytic capacitor characterized in that with respect to the molar ratio between base component (C) and acid component (D) being electrolyte components contained in the electrolyte for electrolytic capacitor, the acid component (D) is in excess.


Blind Source Separation (BSS) is an active domain of Classical Information Processing. The development of Quantum Information Processing has made possible the appearance of Blind Quantum Source Separation (BQSS). This article discusses some consequences of the existence of the entanglement phenomenon, and of the probabilistic aspect of quantum measurements, upon BQSS solutions. It focuses on a pair of spins initially separately prepared in a pure state, and then with an undesired coupling between these spins. An unentanglement criterion is established for the state of an arbitrary qubit pair, expressed first with probability amplitudes and secondly with probabilities. It is stressed that the concept of statistical independence of the sources, widely used in classical BSS, should be used with care in BQSS, and possibly replaced by some disentanglement principle. It is shown that the coefficients of the development of any qubit pair pure state, over the states of the standard basis, can be expressed with the probabilities of results in the measurements of well-chosen spin components.


Anne Brontë's 'A Hymn' was written at a time when hymns were 'of the moment' and many women were engaged in hymnody. It shares with Anne's other religious poems a vision of God as mighty, powerful, loving, merciful and actively interventionist, and a vision of humanity as feeble, inadequate, inconstant and inconsistent. It is distinguished by its exploration of two versions of the universe: one informed by God its Creator and the other its Godless alternative. 'A Hymn' has many traditional stylistic features of hymns and on one level belongs to a familiar class of hymn, the hymn of doubt; but it is also radical in facing head-on an atheistic vision emerging in the nineteenth century.


Silicon is an important mineral element on the earth, because of its crucial role in many biogeochemical processes. Traditionally, silicon cycling is thought to be mainly controlled by rock weathering, subsequent mineral dissolution, and final aggradation in waters. Actually, plants react on the biogeochemical cycling of silicon. A great pool of silicon is contained as the accumulations of amorphous silica (SiO2·nH2O) in living plant tissues, known as biogenic silica (BSi), phytolith or opal. The annual fixation of BSi by terrestrial plants ranges from 1.68×109 to 5.60×109 t. After decomposition, about 92.5% of the BSi from litterfall is absorbed by plants again, and the rest 7.5% remains in soil. Because the silicon absorbed by plants from soil BSi pool is far more than that released by weathering, plant-soil internal cycling can greatly affect the dissolved silicate fluxes from terrestrial ecosystem to rivers and oceans. The annual fixation of BSi by diatom in ocean is from 5.60×109 to 7.84×109 t, about 97% of which is absorbed by diatom again before reaching seabed, and only 1.43×108—2.55×108 t (about 3%) is buried in sediment yearly. In this way, diatom plays an important role in the aquatic cycling of silicon. In conclusion, plants are very important in both terrestrial and aquatic biogeochemical cycling of silicon, and thus, the effects of plants must be considered in the study of global biogeochemical cycling of silicon.


This JAMA Internal Medicine Patient Page describes details of palliative care, including who it can benefit and when it should be considered.


The conventional measure recognises the flexibility of modern credit extension practices. Loans can easily be rolled over or refinanced and, as a consequence, the binding constraint is deemed to be the household's ability to afford the interest payable on the outstanding debt from the household's disposable income. In calculating the interest-only debt-service cost, it is assumed that contracts provide for adjustable interest rates, and a quarterly average interest rate (i.e., prime overdraft rate and predominant mortgage rate for dwellings) is applied to all outstanding amounts of different types of loans extended to the household sector. It should be noted that the household sector includes unincorporated businesses.


In contemporary Western societies, shyness appears to be an increasingly common experience, and yet its sociological relevance has been overlooked. Within psychology, the condition has been seen as an individual pathology, and there has been little attempt to relate this to the wider cultural context. The argument of this article is that shyness can be interpreted as both a privately felt state of mind and a publicly recognized social role. I revisit Mead's conception of the self as an inner conversation between the 'I' and the 'Me', arguing that the shy actor perceives themselves as relatively unskilled in interaction by comparison to a 'Competent Other'. It is then suggested that it is normal for people to drift into isolated episodes of shyness as primary deviance, but that in some cases the reactions of others can lead to a career of secondary deviance. However, while a display of shyness may be normalized in certain situations, in others it can pose a more serious or enduring threat to the residual rules of interaction.This motivates the non-shy majority to defend their normative assumptions by casting moral blame upon the individual, and reframes the 'problem' outside of society.


The Hartree-Fock conduction band structure of solid neon is computed by the APW method. The logarithmic derivatives used have been obtained directly from the static-exchange electron-atom scattering phase shifts. A detailed comparison is made with the existing literature, where the HF conduction bands are obtained with the use of different schemes.


Existing term structure models have often underestimated corporate bond spreads. A potential concern is that personal taxes are ignored in these models. This paper examines the effects of personal taxes on the pricing of corporate bonds. We propose a defaultable bond model that accounts for time-varying default probability and differential tax treatments for discount and premium corporate bonds. By estimating parameters directly from bond data, we obtain significantly positive estimates for the income tax rate of a marginal corporate bond investor after 1986. Results show that personal taxes explain a substantial portion of spreads. Tax effects on average account for about 60%, 49% and 37% of the observed corporate-Treasury yield spreads for AA, A and BBB bonds, respectively. This contrasts sharply with the previous finding that the implied tax rates for Treasury bonds are close to zero. We offer an explanation for this discrepancy in the estimates of marginal income tax rates between corporate and Treasury bonds.


1. Introduction 2. Matrices and Systems of Equations 3. Linear Algebra: Applications 4. Linear Programming 5. Functions of One Variable 6. Functions of One Variable: Applications 7. Systems of Equations, Differentials and Derivatives 8. Taylor Series 9. Vectors 10. Quadratic Forms 11. Multivariate Optimization 12. Equality Constrained Optimization 13. Inequality Constrained Optimization 14. Integration 15. Eigenvalues and Eigenvectors 16. Differential Equations 17. Linear Difference Equations 18. Probability and Distributions 19. Estimation and Hypothesis Testing


Silicon photomultiplier (SiPM) is becoming the photodetector of choice in many applications where good efficiency and precise timing are required. However, their timing performance at very low light intensities is still slightly limited, especially for SiPMs with at least moderately large active surface. Extracting the best timing information from single photon level pulses would be especially desired for the detection of Cherenkov photons in time-of-flight positron emission tomography (TOF PET). To improve the understanding of SiPM timing at low light intensities, we examined the performance of devices produced by four different manufacturers with a picosecond laser. The experiments were performed at a temperature of −25°C. We report on the timing performance of different SiPMs with special emphasis on the details of the double cell signals, where important effects that degrade the timing are most notable.


This work deals with model reactions allowing the synthesis of low-molecular-weight polyurethanes with electrolytic and emulsifier properties. The kinetics of addition reactions of 2,2′-alkyliminodiethanols (3a – c) and their ammonium sulfonate derivatives 5 and 6 with propyl (8a) and cyclohexyl isocyanate (8b) were studied in DMSO and in the bulk. The tertiary amino groups of 3 exhibit catalytic effects, whereas the ammonium sulfonate internal salts inhibit the reaction. 8a is 2 – 3 times more reactive than 8b and the addition rates decrease with increasing R. Autoassociations (OH ··· OH) should mainly be intramolecular because of the proximity of the alcohol groups. In bulk the 8a + 3 additions apparently follow second order kinetics. On the other hand, the third order law must be taken into account with 8b. In contrast, in DMSO, due to the strong (solvent, OH and/or NCO) complexations, the kinetics do neither follow the simple second order, nor the third order law. By the use of two successive second order kinetics, diols were found more reactive than their monoalcohol-monocarbamate derivatives. However, the difference in reactivity decreases with increasing reaction temperatures. Sulfobetaine units may be inserted into the polyurethane chains if diols with ammonium sulfonate groups are used as comonomer, but their weak reactivity must be taken into account.


This paper examines the importance of output growth and of research intensity for productivity growth. Two hypotheses are tested. Firstly, the paper investigates the impact of the two variables on productivity growth when simultaneously considered, assessing whether the basic Kaldorian and Schumpeterian models can be combined. Secondly, it examines whether research intensity impacts on the magnitude of returns to scale, assessing if countries with higher research intensity benefit from higher returns to scale. The tests reported in the paper provide strong evidence of the importance of demand growth for productivity growth and of the existence of increasing returns to scale in manufacturing, while also recognizing the relevance of research intensity for productivity growth. Most importantly, the test results suggest that research intensity has a more relevant impact on the magnitude of returns to scale than directly on productivity growth.


The invention provides a wavelength division multiplexing optical module with pigtails. The optical module is characterized by comprising pigtails, an analog-digital converter, a digital diagnosis monitoring module, a semiconductor cooler, a light emitting assembly and a light receiving assembly, wherein the light emitting assembly and the light receiving assembly are respectively connected with the analog-digital converter, the analog-digital converter is connected with the digital diagnosis monitoring module, the digital diagnosis monitoring module is connected with the semiconductor cooler, the light receiving assembly is connected with a broken end of each pigtail in a fuse way, and the light emitting assembly is connected with a connector of each pigtail. The wavelength division multiplexing optical module has the beneficial effects that the migration (multiplexing) and partial wave (demultiplexing) of the emission and the receiving can be completed, so that the transmission capacity of a single optical fiber can be doubled, the single-fiber bi-direction communication can be realized, and the attenuation of the optical power brought by a bi-directional (BIDI) single fiber structure because a 45-DEG wave plate is needed for the emission also can be avoided.


The experiment was carried out in slovenia in 2002-03 and 2004-05. The experimental design was a randomized completed block, with four replicates. In the summer after pea harvesting, 10, 20 and 30 kg of italian ryegrass ha-1 were drilled into minimally cultivated pea stubble, in which, on average, 12.5 pea grains m-2 were left among crop residues. The ryegrass/pea mixtures in our experiments took up the soil mineral nitrogen the most efficiently and accumulated the highest amount of nitrogen in the autumn herbage yield, at a seeding rate of 30 kg drilled Italian ryegrass. The differences among treatments regarding 0–60 cm soil no3-n and nh4-n contents were highest at the first cut and decreased until March of the next year. In order to achieve efficient early and high n uptake of mineralized nitrogen, it is not recommended to lower the sowing rates of italian ryegrass for drilling into pea stubble to reduce the high cost of catch


Introduction: Tissue class segmentation is integral to many MRI analyses. The process is complicated by noise, scan gain parameters, and bias field. Modern segmentation approaches rely on location-based tissue class prior probability maps to estimate bias field and segment the brain, thereby necessitating an accurate spatial registration of the observed image to the template image of the priors' space. The interdependence of segmentation, registration, and bias correction results in an optimization problem with a large number of parameters best handled in a unified model [1]. Here we describe a novel approach for creating tissue prior maps that offers many advantages over current location-based templates. We propose to gain information about a voxel's tissue type by examining at each voxel the 3D texture of the image over multiple spatial scales, and comparing it to textures from a training set. This collection of texture information over spatial scales is termed a voxel's signature. We hypothesize that voxels of different tissue types can be differentiated on the basis of their signatures, at least as well as location-based spatial priors can do. Methods: Each voxel's signature was formed as a collection of three statistics (median, Median Absolute Deviation, and Pearson's 2 skewness coefficient) computed over voxels inside balls of radii from 1 to 19mm. Assuming that bias field is approximately constant over the largest radius, it is straightforward to show that skew statistics are independent of bias field, and that median and MAD are approximately independent of bias field if detrended and scaled by MAD estimated at the largest spatial scale of 19mm. We tested our approach using the publicly available IBSR dataset of T1-weighted MRI volumes, and their manual segmentations [2]. The volumes were from 18 subjects (4 females, 14 males) , with subject ages ranging from juvenile (< 8) to 71 years and voxel resolution approx. 1x1x1.5mm. For each tissue class, a randomly selected training sample of 300 (~ 0.3% of voxels in dataset) signatures was taken from three (s05, s11, and s14) of the 18 subjects. We used libSVM [3] to carry out SVM training and testing on all 18 volumes, and on a version of the same datasets with additional 80% bias field modeled with third order Legendre polynomials. To compare the performance of location-based and signature-based priors, we create priors-only segmentations by assigning to each voxel the class with the highest prior probability and compared them to the manual segmentation with the Dice coefficient. We used non-linear registration to bring the anatomical template of location-based priors distributed with FSL [4] in registration with each of the anatomical volumes. No registration was necessary for signature-based priors as they are generated in subject space. Results: Figure 1 shows a sample set of priors for one subject. Note how signature based priors are more faithful to the anatomy despite being derived from statistics covering multi voxel neighborhoods. Figure 2 shows Dice coefficients of priors-only-based classification. For all three tissue classes and most subjects, signature-based priors were superior to location-based ones, particularly for white matter whose Dice coefficients rose considerably (p<0.01) with signature-based priors. The addition of 80% bias field had little effect on the performance of signature based priors. We emphasize that the priors-only classification is meant to illustrate the improvement of signature-based priors compared to location-based ones, not as an end result of segmentation.


Abstract 1206 Poster Board I-228 [Study purpose] With the increased number of cord blood transplantation (CBT) for adults, more human leukocyte antigen (HLA)-mismatched grafts are selected as alternative donor. In Japan, we have performed more than 5,500 CBT and almost two-third of them has been using 2-loci HLA-mismatched grafts. Slow engraftment and high risk of graft failure should be solved to improve the clinical results. In general, the degree of HLA disparity is known to be associated with risks of poor graft function and of graft-versus-host disease (GVHD). On the other hand, those risks of transplant-related complications are not equivalent even in the donor-recipient pairs who have same number of mismatched HLA antigens. There might be "haplotype matching effect" because novel undetected major histocompatiblility antigen (MHC) resident variation encoded on HLA haplotypes and those mismatching could be responsible for post-transplant risks. In this study, we have analyzed the impact of HLA haplotype matching in HLA-mismatched CBT using the same method in the single institute. [Patients and Methods] We studied the clinical outcomes of 149 consecutive adult patients who received unrelated CBT between August 1998 and June 2009 in the institute of medical Science, University of Tokyo. Patients received previous allogeneic tranplants were excluded from this study. All patients received myeloablative regimens including 12 Gy of total body irradiation, cyclosporine plus short term methotraxate for GVHD prophylaxis and almost the same supportive care. By low-resolution typing method for HLA-A, -B and –DR loci, 9 patients received matched grafts, 46 received 1 antigen-mismatched and 94 received 2 antigens-mismatched grafts in the host-versus-graft (HvG) direction. In the graft-versus-host (GvH) direction, 7 patients received matched grafts, 51 received 1 antigen-mismatched and 91 received 2 antigens-mismatched grafts. When we looked at the maximum number of mismatched antigens for both directions, 38 patients received 1 antigen-mismatched and 111 received 2 antigens-mismatched grafts respectively, but there was no matched pair. Common haplotypes in Japanese population were referred from the 11th International Histocompatibility Workshop and other previous reports. Median numbers of leukocytes and CD34+ progenitor cells before freezing of cord blood grafts were 2.4×107/kg and 0.9×105/kg, respectively. Median follow-up was 39 months. We evaluated the impact of haplotype matching on cumulative incidences of hematopoietic recovery, of GVHD, of relapse and of non-relapse mortality (NRM) using the Pepe and Mori9s test. Estimates of overall survival were calculated using the Kaplan-Meier method and analyzed by the log-rank test. [Results] Thirty (11 of 38 one antigen-mismatched and 19 of 111 two antigens-mismatched) among all 149 pairs were defined as the haplotype-matched pairs sharing same haplotypes in both grafts and recipients. The age, sex, cytomegalovirus serological status, diagnosis, risk of the disease at the transplant, numbers of total nucleated cells and CD34+ cells at the cryopreserved were not significantly different between both groups with and without matched haplotypes. Among the 1 antigen-mismatched pairs in the HvG direction, early engraftment of neutrophil after CBT occurred in haplotype-matched group compared with control group (median: 20.5 days versus 23 days, P=0.01). The haplotype matched group had better platelet engraftment in the 1 antigen-mismatched pairs (cumulative incidence on day 120: 86% versus 62%; median: 41 days versus 53 days), but this is not significant (P=0.29). Such correlation between engraftment and haplotype matching was not observed in 2 antigens-mismatched pairs. The cumulative incidences of grades II to IV acute GVHD were not significantly different between haplotype matched and control groups, however, those of grades III and IV in patients with matched-haplotype tended to be lower among 1 antigen-mismatched pairs in GvH direction (P=0.10) and were significantly lower among 2 antigens-mismatched pairs (P=0.02). Those haplotype matching effects were not observed in survival rates, cumulative incidences of relapse and NRM among any HLA mismatched pairs. [Conclusion] Those data suggest that untyped variation carried on the HLA haplotytpe might be better to be matched and the haplotype matching might effect on better engraftment and lower risk of sever acute GVHD after HLA-mismatched CBT. Disclosures: No relevant conflicts of interest to declare.


Abstract : ,Distribution, tenacity and chemical composition of sulphide films produced by bacteria within bioflims were compared with those produced by waterborne inorganic hides. Attempts were made to differentiate corrosion mechanisms of alloy 400 (70Ni - 30Cu) exposed to seawater in the presence of absence of sulphate-reducing bacteria (SRB). Experiments were conducted in an anaerobic environment in the presence of inorganic sulphide and sulphate-reducing bacteria (SRB) either freely corrosion of coupled to an external cathode (alloy 400) exposed air. Sulphur concentration in the films increased in the presence of SRB as well as when samples were coupled to an external cathode. Bacteria encrusted with corrosion products and integrated into the sulphide film were only observed in the presence of SRB in addition to coupling with an external cathode.


In this study, water depth optima, i.e. habitat preferences within a depth gradient, were estimated for mutual midge (Diptera: Nematocera; Ceratopogonidae, Chironomidae) taxa in surface sediment intralake data sets from eastern Finland and Austrian Alps and in a regional data set across Finland. The aim was to investigate how the optima and tolerances differ in these data sets and to discuss whether the possible causal factor for deviance is related to local adaptation, taxa representativeness, or some other factor. A total of 20 mutual taxa were found from the data sets and the estimated optima and tolerances were highly similar, with the exception of three taxa, which had deviating optima in the Austrian lake. The reason for these differences was most likely that the optima were poorly estimated in the Austrian lake due to low abundances and number of occurrences of these taxa. No evidence for intraspecific niche separation or local habitat adaptation was found between the Austrian and Finnish sites, although, interspecific variation in habitats was evident. Therefore, water depth optima estimated from representative number of specimens may be applicable for various ecological, limnological, and paleolimnological purposes. However, when the optima are applied outside the data set's coverage, the results should be interpreted with caution. In addition, the given optima are not applicable in sites deeper than the sites in the data sets.


All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without permission from the author.


Sampling inspection by variables for percent nonconforming, such as with the use of MIL-STD-414, also provides the data for estimating the population percent nonconforming. A method is provided for obtaining a confidence interval for the population valu..


Around 1050, a magnificent crucifix was donated to the former female collegiate church of St Nikomedes (now parish church) at Borghorst, Westphalia (Fig. 1–2).1 The Borghorst Cross, as this crucifix is more commonly known, is a reliquary splen didly decorated with gold, gems and precious stones, as was a longstanding custom in church practice. Just like many other reliquaries of the same period, it includes inscriptions to identify the images depicted on both sides of the cross and the relics concealed inside. These inscriptions form the subject of this paper. Using the Borghorst Cross as a case study, this article hopes to contribute to a better under standing of the interplay between inscriptions and relics, by exploring how writing, as both a textual and visual device, interacted with the physical context in which the relics were placed, contributed to its meanings, and engaged medieval audiences.2 The type of context that concerns us here is, first, that of the portable reliquary and, second, the wider architectural and liturgical context in which the inscribed reliquary was displayed and set in motion, as an object meant to be seen and contemplated by the faithful who came to pray in the church. Although the focus is on one case study, the methodology of this paper has been developed on the basis of a large corpus of inscribed reliquaries from western medi eval Europe.3 It addresses the inscriptions as material components of all reliquaries, exploring their textual and visual functioning within the larger system to which they belong. Using the epigraphic programme of the Borghorst Cross, I argue that the ways in which epigraphic texts on reliquaries conveyed meanings and contributed to these objects' significance and functions, were inherently linked to the interactions between the inscribed text and its context, including the inscriptions' interactions with the surrounding images, materials, decorations, the shape of the reliquary, the relics concealed inside, and the faithful, the author or spectators of the epigraphic object. The cross of St Nikomedes allows me to explore some of these interactions,


P450s, remain unknown primarily due to challenges in handling these membrane spanning proteins. Here we studied for the first time with single molecule resolution the function of POR(2). To ensure that we recorded the inherent behavior of POR we reconstituted the full length enzyme in ''native like'' membrane patches Nanodiscs. Nanodiscs reconstitution increased POR stability ~2 fold as compared to POR solubilized in detergents highlighting the need for membrane environment to reliably study transmembrane protein behavior. Importantly it allowed the immobilization of individual POR enzyme on microscope slides(3-5) and their single turnover readout using the prefluorescent analogue resazurin. Measurements and statistical analysis of individual catalytic turnover cycles shows POR to sample at least two major functional states. Each of these states could have different specificities for each P450 downstream partners providing cues for their selective activation(6) but to date remained masked in bulk kinetics 1.Fluck CE, Tajima T, Pandey AV, Arlt W, et al. (2004) Nat. Genet. 36(3):228-230. 2.Laursen T, Singha A, Rantzau N, Tutkus M, et al. (2014) ACS Chem. Biol. 9(3):630-634. 3.Hatzakis NS, Wei L, Jorgensen SK, Kunding AH, et al. (2012) J. Am. Chem. Soc. 134(22):9296-9302. 4.Christensen SM, Bolinger PY, Hatzakis NS, Mortensen MW, & Stamou D (2012) Nat. Nanotech. 7(1):51-55. 5.Hatzakis NS, Bhatia VK, Larsen J, Madsen KL, et al. (2009) Nat. Chem. Biol. 5(11):835-841. 6.Hatzakis NS (2014) Biophys. Chem. 186(0):46-54.


Abstract The paper presents the results of tribological and nanoscale research on model friction couples intended for hip joint prostheses. The tribological tests were performed by means of reciprocating pin on plate testing machine. The investigated friction pairs contained plates rubbing against polymer pins. The test plates were made from seven kinds of ceramics containing different concentrations of ZrO2 and Al2O3, and two kinds of Co–Cr alloy. The test pins were made from UHMWPE. Tribological tests were performed in conditions of Ringer solution circulation. On the basis of friction force measurements, for each investigated friction couple, the average coefficient of friction was calculated. On the basis of total wear measurements, for each investigated couple, the wear intensity was calculated. Before and after every test, the plates and pins were analysed by means of atomic force microscopy. The difference in plate surface roughness was determined by the results of the atomic force microscopy analyses. It was stated, that in the case of investigated friction joints, working under reciprocating motion, the wear and friction coefficient correlates with the surface roughness of plate specimens. For the plates with higher surface roughness, the lower friction coefficient and also lower UHMWPE pin wear intensity were observed. The friction coefficient and wear intensity were increasing with decreasing surface roughness. The correlation is confirmed by the differences in material transfer process. Considering investigated friction couples, the pin polymer material is smeared on the ceramic plates with the highest surface roughness creating a thin polymer film. In the case of ceramic surfaces with the lowest surface roughness, the strong adhesive bounds are created and some large particles of polymer are transferred to ceramic surface.


In this paper, a sliding mode control method with uncertainty adaptation is proposed by introducing the virtual state. Because upper bound of the uncertainty is very difficult to know, we estimate this by using the simple adaptation law and design the sliding surface which has dynamic of nominal system. An optimal controller is used by nominal controller. And if initial values of the virtual state are chosen properly, the reaching phase is removed.


From absorption spectra obtained with infrared reflection−absorption spectroscopy (IRRAS), it is possible to obtain information on conformational changes at a secondary folding level of proteins adsorbed at the air/water interface. In addition, information on protein concentration at the interface can be retrieved by means of spectral simulation. In this paper, we studied the adsorption behavior of β-casein, β-lactoglobulin, and (soy) glycinin at the air/water interface and the conformational changes that may take place during adsorption. The adsorbed amount was determined as a function of time, and the values found for the three proteins agree well with ellipsometry data. Only limited conformational changes in terms of secondary structure were found. Upon adsorption at the air/water interface, loss of β-sheet structure was observed for β-lactoglobulin whereas the amount of unordered structure increased. For glycinin (pH 3), aggregation at the interface was observed by the appearance of an absorption band...


nloaded kground: We aimed to define the potential of the fecal DNA assay as an alternative or in addition to rrently used immunochemical fecal occult blood test (iFOBT) for the early diagnosis of colorectal . thods: A total of 560 individuals aged 50 to 69 years with a positive iFOBT were recruited from an FOBT regional screening program. Twenty-six were diagnosed with adenocarcinoma, 264 with isk adenoma, and 54 with low-risk adenoma, whereas 216 subjects did not have premalignant or ant lesions. Fecal DNA integrity was analyzed blindly by the fluorescence long DNA (FL-DNA) test. ults: iFOBT and FL-DNAwere largely independent variables (rs = 0.036, P = 0.42), with values ranging 01 to 5,826 ng/mL and from 0 to 515 ng, respectively. Median values of both variables were signifihigher in cancer patients than in patients with noncancerous lesions or in healthy individuals. MoreiFOBT and FL-DNA values were individually associated with a number of pathologic parameters. ntial use of the diagnostic iFOBT and FL-DNA methods showed that fecal DNA provided more accuiagnostic information and was able to identify subgroups at different risk of cancer in iFOBT-positive duals. clusions: A combined approach based on FL-DNA and iFOBT evaluation could help to better identify ctal cancers and to determine a patient's risk of harboring a preneoplastic or neoplastic lesion. Further tion in a screening setting is needed to confirm this hypothesis. evalua Impact: Fecal DNA could be a useful tool to better predict cancer risk in FOBT-positive individuals. Cancer Epidemiol Biomarkers Prev; 19(10); 2647–54. ©2010 AACR.


Cooperative networks have been appreciated for their spatial diversity benefits in wireless communications. In this paper, we will explore the error performance of cooperative networks depending on the relay locations. Both decode-and-forward (DF) and amplify-and-forward (AF) relaying protocols are considered with an arbitrary number of relays. To provide simple transceiver structure, differential modulation scheme is adopted for both protocols. The effect of relay locations is investigated by considering the number of relays and transmit energy including energy optimization. We show that there exists a common point where the error performance of both protocols coincides. Based on these results, we can achieve the improvement in error performance by choosing the relaying protocol depending on relay locations.


The Ryukyus, surrounded on three sides by major powers of East Asia, are the most strategic outposts of freedom in the Far East. Known as the "Keystone of the Pacific," Okinawa, the most important island, is 800 nautical miles southwest of Tokyo, 325 nautical miles northeast of Taipei, 750 nautical miles northeast of Manila, and 700 nautical miles northeast of Hong Kong.This article can also be found at the Monthly Review website, where most recent articles are published in full.Click here to purchase a PDF version of this article at the Monthly Review website.


This study was carried out to determine the pharmacokinetics of chloramphenicol in eight sheep injected intramuscularly with chloramphenicol sodium succinate (25 mg/kg body weight). The animals were bled at pre-determined time intervals and serum chloramphenicol concentrations monitored using chloramphenicol-ELISA for a period of 30 days post drug administration. Pharmacokinetic evaluation was carried out using a non-compartment analysis. The mean Cmax values obtained in the eight sheep was 134±34 mg/ml and the time required to reach Cmax (tmax) was 10±0.05 minutes. The mean elimination half-life obtained was 36.37±3.7 h and the mean residence time was 2.83±0.27 h. These findings show that chloramphenicol was absorbed and distributed rapidly from the injection site. At two weeks post drug administration, the drug levels had declined to below the limit of detection of the assay (0.1 ng/ml).Keywords: Chloramphenicol, pharmacokinetics, sheep, ELISAEast and Central African Journal of Pharmaceutical Sciences Vol. 12 (2009) 3-7


"Secure and Sustainable" digitization plays a vital role for Indian economy to achieve global leadership. India's experience, towards the transformative changes in governance and socio-economic development, has resulted in the formation of digital revolution. With the optimum usage of computing technologies, huge Internet connectivity and reliable networking in the sectors like digital literacy, financial inclusion, rural development and e-governance has triggered the sustainabilty growth of Digital India. However, the Digital tools taken under the sustainable measures have created significant risks and attacks. The level of increase in cybercrimes in recent developments has drastically effected the sustainable growth of digital economy. This study will explore the two most common and prominent sides of the digital economy: Security and Sustainability. The major drawback seen in the economy is the study of these perspectives individually. Digital revolution needs to have a correlation between the sustainable measures and their secuirty measures as unified objective. This study will be the base to inter-relate these two perspectives, so as to reach the sustainable development goals of Digital India. The objective of the research study is to revisit the requirements of secure sustainable Digital India. The imperative focus is to present a broad overview about the digital security and digital sustainabilty as the major features to transform the Indian economy. The paper aims to review and emphasis on conclusive findings for future research in the related domain based on the published work and industry/organization reports.


Recently, the power of Gaia data has revealed an enhancement of high-mass white dwarfs (WDs) on the Hertzsprung–Russell diagram, called the Q branch. This branch is located at the high-mass end of the recently identified crystallization branch. Investigating its properties, we find that the number density and velocity distribution on the Q branch cannot be explained by the cooling delay of crystallization alone, suggesting the existence of an extra cooling delay. To quantify this delay, we statistically compare two age indicators—the dynamical age inferred from transverse velocity, and the photometric isochrone age—for more than one thousand high-mass WDs (1.08–1.23 M⊙) selected from Gaia Data Release 2. We show that about 6% of the high-mass WDs must experience an 8 Gyr extra cooling delay on the Q branch, in addition to the crystallization and merger delays. This cooling anomaly is a challenge for WD cooling models. We point out that 22Ne settling in C/O-core WDs could account for this extra cooling delay.


The complex permittivity and permeability of Dravite, Elbaite, ZnO and Dravite/ZnO complex powder are analyzed in this paper. Within the frequency range of 2~18 GHz, the dielectric losses of these four materials are in the sequence of: 0 ≈ Dravite ≈Elbaite < ZnO < coated powder = 0.211. The complex powder's magnetic loss decreases gradually with the increase of frequency. The magnetic loss is between 0.05 and 0.15 at the frequency ranging from 2 to 6 GHz. The research has shown that Dravite/ZnO complex powder exhibits some microwave absorbing capability, which may widen the application of tourmaline in the field of environmental depollution.


Science Management Corporation collected and analyzed data for the Autumn 1979 appraisal of GRI's 1981 R and D program. Thirty-five project areas were analyzed for GRI Programs in Supply, Environment and Safety, and Efficient Utilization. These data included estimates of gas supplied or saved by research in a project area; costs associated with new technology; impacts on safety, reliability and the environment; and legal, social and institutional effects.


As its title suggests, this study argues that U.S. immigration policy has been fundamentally shaped by national sovereignty. In so doing, Cheryl Shanks usefully reminds us that immigration is one of those policy domains—like foreign policy—that is inescapably and fundamentally regime shaping. At the same time, she seeks to demonstrate that "to preserve or enhance sovereignty is a policy choice" (p. 2), albeit one whose determinants change over time. Indeed, the bulk of this work is an historical analysis of the Congressional Record, scrutinizing how U.S. sovereignty has been conceived of differently over the last century and how this has influenced immigration policy. This effort leads Shanks to the provocative conclusion that "immigration policy has become more restrictive as trade policy has become less protectionist" (p. 253); more specifically, that as we have become less concerned with racial and ideological admission criteria, we have become more concerned with total numbers of immigrants and their "quality," in terms of human capital. For Shanks, the point is that the tension between maintaining sovereignty and fostering involvement in an open and dynamic world economy is central to understanding contemporary immigration policy.


"Democracy is founded on the principle that each individual has equal value. Treating some as automatically having less value than others not only causes pain and distress to that person but also violates his or her dignity as a human being. The essence of the Convention, as has often been said, is respect for human dignity and human freedom . . . Second, such treatment is damaging to society as a whole. Wrongly to assume that some people have talents and others do not is a huge waste of human resources. It also damages social cohesion, creating not only an under class, but an under class with a rational grievance. Third, it is the reverse of the rational behaviour we now expect of Government and the State. Power must not be exercised arbitrarily. If distinctions are to be drawn, particularly upon a group basis, it is an important discipline to look for a rational basis for those distinctions. Finally, it is a purpose of all human rights instruments to secure the protection of the essential rights of members of minority groups, even when they are unpopular with the majority. Democracy values everyone equally even if the majority does not."1


Despite a dizzying rate of therapeutic advances for metastatic melanoma over the past 5 years, the majority of patients are still succumbing to their disease. Novel immune therapies, with inhibitors of immune checkpoints as the most impactful at a population level, are broadly relevant across the metastatic melanoma population and produce apparently permanent disease control/response in a minority of patients. However, adoption of these therapies into routine clinical practice has created the view that these agents are most effective in patients with low disease burden or indolent disease kinetics. Signal transduction targeted therapy has gained the greatest traction in BRAF mutant melanomas, which account for approximately 40–50% of the entire population. Combined BRAF/MEK targeted therapy can produce profound tumor regressions even in patients with high disease burden and rapid growth kinetics, but with highly variable duration. 3 Nascent efforts to establish the benefit of MAP kinase pathway targeted therapy in other genetically-defined melanoma subsets are still in progress. A major area of interest in the field currently is the development of combination regimens that are able to leverage the rapid and confident disease control features of BRAF inhibitor-based therapy with the long-term impact of immune checkpoint inhibitors. On purely clinical grounds, a case can be made for the imperative of resolving combination or rapid sequential approaches with cytotoxic (signal transduction targeted therapies in the case of melanoma) with immunologic treatments. Multiple lines of evidence support a potential mechanistic intersection between MAP kinase pathway targeted therapy and immune therapy, at least in BRAF mutant cancers. Two groups have shown that BRAF inhibitors alone or in combination with MEK inhibitors are associated with a consistently increased infiltration of CD8C T cells into tumor when biopsies before and early during the course of therapy. 4,5 Additionally, melanocyte lineage antigen presentation appears to increase consistently in an MITF dependent fashion in both experimental models and in patients. And, exposure of autologous T cells to tumor cells in the presence of BRAF inhibitor ex vivo promotes, not inhibits, T cell activation, proliferation and production of interferon gamma. While these observations point toward a largely positive immunologic effects, there is evidence that some tumor upregulate expression of PD-L1, which could promote continued escape from immune surveillance. While mechanistic underpinnings of these phenomena await further clarification, they support the concept that synergy may be achievable with signal transduction and immune checkpoint inhibitor therapy. Wyluda and colleagues intriguing cases of patients who were treated serially with high-dose interleukin-2, followed by ipilimumab in the presence of disease progression, and then BRAF inhibitor monotherapy, again triggered by disease progression[Wyluda et al. CB&T 2015]. In each case, complete responses were observed which were ongoing at the time of this report (up to 15 months for the patient with longest follow-up). Certainly, complete response to BRAF inhibitor monotherapy are an uncommon event (approximately 5% from large-scale phase II and III trials of vemurafenib and


Summary In this paper, a new model for joint dynamic friction of industrial robot manipulators is presented. In particular, the effects of the temperature in the joints are considered. A polynomial-based model is proposed and the parameter estimation is performed without the need of a joint temperature sensor. The use of an observer is then proposed to compensate for the uncertainty in the initial estimation of the temperature value. A large experimental campaign show that the model, in spite of the simplifying assumptions made, is effective in estimating the joint temperature and therefore the friction torque during the robot operations, even for values of velocities that have not been previously employed.


In this paper, a hybrid system of optics and computer for 3D object recognition is presented. The system consists of a Twyman-Green interferometer, a He-Ne laser, a computer, a TV camera, and an image processor. The structured light produced by a Twyman-Green interferometer is split in and illuminates objects in two directions at the same time. Moire contour is formed on the surface of object. In order to delete unwanted patterns in moire contour, we don't utilize the moire contour on the surface of object. We place a TV camera in the middle of the angle between two illuminating directions and take two groups of deformed fringes on the surface of objects. Two groups of deformed fringes are processed using the digital image processing system controlled and operated by XOR logic in the computer, moire fringes are then extracted from the complicated environment. 3D coordinates of points of the object are obtained after moire fringe is followed, and points belonging to the same fringe are given the same altitude. The object is described by its projected drawings in three coordinate planes. The projected drawings in three coordinate planes of the known objects are stored in the library of judgment. The object can be recognized by inquiring the library of judgment.


Introduction: The changing context of work with young people Introduction: The changing context of work with young people - Jason Wood and Jean Hine Part One: Theory and Practice Changing Conceptions of Youth in Late Modernity - Alan France Young People's Lives: Taking a different view - Jean Hine Globalisation and Global Youth Work - Jo Aubrey Ethics and Values in Work with Young People - Sarah Banks Anti-Oppressive Practice - agdish Chouhan Educating Youth: Assimilation and the democratic alternative - Derrick Armstrong Social Capital and Young People - Thilo Boeck Community Youth Development - Daniel F. Perkins Young People and Research Participation - Jennie Fleming and Nicky Hudson Part Two: Policy and Practice European Youth Policy and the Place of the United Kingdom - Howard Williamson Education for Effective Citizenship - Jason Wood Risk, Social Policy and Young People - Hazel Kemshall Youth Justice: moving in an anti-social direction - Joe Yates Good Practice in Guidance: Lessons from Connexions - Scott Yates Youth Work and the Youth Service - Bernard Davies Youth Work and the Voluntary Sector - Tom Wylie Modern Youth Work: Purity or common cause? - Malcolm Payne Managing the Tensions - Mary Tyler Working with Young People: Emergent themes - Jean Hine and Jason Wood References


Introduction Hepatocellular carcinoma (HCC) remains a major clinical problem as more than half of these cases recur after radical resection. Natural killer (NK) cells are at the forefront of the innate immune system and attack microcarcinomas and circulating tumour cells. The objective of this study was to evaluate the feasibility and toxicity of peripheral blood CD34+ stem cell-derived NK cell infusion after radical hepatectomy for HCC. Methods and analysis This is an open-label, single-arm, single-centre phase I study. Patients who have undergone initial hepatectomy for HCC with three or more risk factors for recurrence (≥10 ng/mL of Alpha fetoprotein (AFP), ≥360 mAU/mL of PIVKA-II, multiple tumours and ≥3 peripheral blood circulating tumour cells) will be enrolled and be treated with three peripheral blood CD34+ stem cell-derived NK cell infusions every 3 months. The primary endpoint will be safety assessment including the type and severity of adverse events, frequency of occurrence and duration of occurrence. The secondary endpoints will include survival, effect of immune response and clinical laboratory test results. Ethics and dissemination Ethical approval of the trial was obtained from the Certified Committee for Regenerative Medicine Hiroshima University in Japan. The trial results will be shared with the scientific community at international conferences and by publication in a peer-reviewed journal. Trial registration number jRCTb060200020.


Providing a composition for the prevention or treatment of diseases associated with the production of autoantibodies. Containing royal jelly as an active ingredient, a composition for the prevention or treatment of diseases associated with the production of autoantibodies.


Cloud computing (CC) has become a very popular computing model in the last decade, as it has proved to be a cost-effective alternative to large-scale computers hosted in conventional Information Technologies (IT) department. The ability to provide on-demand IT-related resources either through the internet (public clouds) or private networks (private clouds) based on customer's needs, and the scalability they have to deliver resources horizontally, can be considered the main reasons for such popularity and have led such a CC platforms to a scenario involving the hosting of other types of systems, such as those that control large volume of data, like database management systems (DBMS).


I a previous issue of thia Review * we set out certain observations which we think may be of use when trying to establish a connexion between economic conditions and crime. It ia our aim now to utilize the method outlined in that article in examining the problem empirically, that ia, by studying the relationship between cnme and econonuc conditions in a given social environment at a given period of time. For thia purpoae we have selected the sodal environment of Poland in the yeara fix>m 1928 to 1934 becauae it offers exceptional poaaibilitie8 for auch a study. The principal advantages of thia r>felection are as follows: (a) Police atatiatics are fuUy available for Stius period, and theae atatiatics, aa we have endeavoured to ahow, are ^ o r our present purpose more auitable than any other kind of jgcriminal atatiatics. {b) Becauae of their ayatem of recording (practically uniform all over the country) and of the system of compilation (a minute differentiation of the various types of crime recorded) the Polish police statistics of thia period present a very high degree of precision. (<r) We were forttmate in being able to go direct to the source to consult the police files, and ourselves to make all the calculations necessary for the purpose of this study.* (rf) We preceded these investigations by a detailed inquiry into the movement and distribution of crime in Poland over a period of 15 years—a proceeding which allowed us to obtain a certain insight into the defects of the ^dbresaid police statistics and aho\fed us to what extent we could rely on and utilize them, (e) Aa regards economic data we were particularly fortunate in obtaining valuable and trustwdlthy material from the Institute for the Study of the Economic Situation attached to the Ministry of Indtistry and Trade which functioned at this particular period.* ( /) This economic material


BACKGROUND : In Central Java, Abortus is a cause directly of maternal death, this is showed by abortion prevelance of 2 million cases in 2013, with a ratio 37% to 1000 births in productives times (Depkes 2014). OBJECTIVE : Giving midwifery care for pregnant Mrs. L. 22 years old ,GIP0A0 gestational age 17 weeks with abortus immminen. METHOD : LTA is a case study report using method of obtaining data that used with main purpose to make an objective description of the situation. RESULT : midwifery care for pregnant Mrs. L. 22 years old ,GIP0A0 gestational age 17 weeks with abortus immminen. CONCLUSION : From the case of Mrs. L ,there are no differences between theory and practice
Key Words :Pregnancy, Abortus Complet


To the Editor: I read the article of Hauben et al with interest. In a study published 6 years ago, a definite relationship between areola-nipple proportion was established, which I termed the "esthetic nipple-areola unit." The ratio was 1:3.6 instead of 1:3 advocated by Hauben et al. It needs to be pointed out (excuse the pun), though, that my study group, which included 40 nipple-areola complexes, was more coherent in terms of age. The ratio of 1:3.6 translates to a nipple diameter 28% of the areola diameter, whereas 1:3 translates to 33 1/3 (ie, a difference of 5%). I venture to suggest that the practicing surgeon, who is inclined to "eyeball" the proportions rather than measure exactly, plan a "new" nipple to be approximately one third of the areola diameter in the older, nonelastic, more ptotic breast and a somewhat smaller (definitely less than one third) in the younger breast to avoid possibly creating an iatrogenic nummular nipple.


In 1969 there was a lengthy debate in the US senate and before its committees on the ABM (or AntiBallistic Missile) which was designed to shoot down the ICBM (or InterContinental Ballistic Missile). The ABM had been developed over many years at a cost of a few billions of dollars, and it was now proposed to manufacture and install this weapons system for the defense of the continental United States at a cost of many billions of dollars. This debate was salutary because, among other things, it was the first time that the technological arguments, which should be one of the important considerations in such a political decision as whether to deploy an ABM, were fully explored before the public.


Introduction/aim Clinical signs and symptoms of pulmonary embolism (PE) are non-specific, which is why it is commonly not diagnosed on time or sometimes not diagnosed at all. We are presenting a case of pulmonary embolism manifesting with syncope as a dominant symptom. Case report A 74-year-old female patient was hospitalized at the Clinic for Pulmonary Diseases with PE manifested with syncope. At admission, she was afebrile, tachypneic, with normal cardiac function and normal blood tension. Upon auscultation, breathing was muffled with late inspiration crackles above the base of the left lung. There were no other significant findings. The chest X-ray recorded at admission showed a non-homogenous shadow towards the base of the left lung and minimal pleural effusion. The ECG and echocardiography findings were normal. Partial respiratory insufficiency was verified by the acid-base balance analysis. Inflammatory markers were significantly elevated, with erythrocyte sedimentation rate of 30mm/h, fibrinogen of 8.62g/l and D-dimer of 18.6mg/l. Anticardiolipin IgG and IgM antibodies were negative, as well as beta-2 GPI IgG and IgM antibodies. An MDCT lung angiography was performed because of the elevated values of D-dimer and tachypnea, which showed multiple emboli of various sizes in the distal part of the right pulmonary artery and all lobar branches, as well as an embolus in the lobar branch for the lower lobe of the left lung. After a neurology consult, a head CT was ordered because the patient had suffered from loss of consciousness, but there were no pathological densities in the brain. Colour Doppler Ultrasonography of the blood vessels in the lower extremities showed organized thrombosis of the left femoral vein. A vascular surgeon was consulted and he prescribed anticoagulant therapy and an elastic compressive stocking, with control Colour Doppler Ultrasonography to be performed in six months. Conclusion Although syncope is an easily detectable symptom, it is still an unregulated crossroad of many an internal and neurological disease.


Lifting wavelet algorithm is a newmethod of first generation wavelet transform decomposed of finity step,by which analysis of frequency-domain characteristic of signal can be completed rightly after signal transformation at time domain.These make the complexity of computation to lower greatly and the working time to reduce effectively at hardware implement.The authors apply lifting scheme of Daubechies 9/7 wavelet filter to the harmonic detection.Results from simulation show that Lifting wavelet algorithm can meet the requirements in the real-time monitoring of harmonic in the power system.


Metal-organic framework (MOF)-derived metal oxide@nanoporous carbon (NC) has attracted increasing interest in recent years since nanoscale metal oxides can be well dispersed in carbon matrices. Herein, we report the synthesis of MOF-derived MgO/Mg(OH)2@NC, which shows high thermal energy release and storage through reversible chemical transformations. The reversible phase transition triggered by hydration and dehydration was confirmed by powder X-ray diffraction (PXRD). MOF-derived MgO@NC exhibits greater heat release compared to commercially available MgO because of its large surface area and homogeneous distribution of nanometer-sized MgO particles in the NC matrix.


We report on the role of hydrogen surface passivation in achieving low‐temperature silicon epitaxy by chemical vapor deposition processes. Upon insertion of an HF‐etched silicon wafer into an epitaxial silicon deposition apparatus, residual contamination of the Si surface is negligible. Si 2p core level photoemission spectra demonstrate that the silicon surface is stable in air and free of SiO2 for a time period of minutes. The predominant passivating species is found to be silicon hydride. We demonstrate that hydrogen passivation by HF pretreatment leads to two divergent temperature ranges where epitaxy is successful, those being a low‐temperature range, 425≲T≲650 °C, and a high‐temperature regime, T≳750 °C. Additionally, we employ temperature‐programmed desorption techniques to elucidate the role of hydrogen in the transition to a steady‐state growth process, employing ultrahigh vacuum/chemical vapor deposition as the model system.


The inclusion of students policy with special educational needs in the regular school system, not merely the physical remains of these students together with other students, but is the need to review concepts and paradigms, as well as develop the potential of these people, respecting their differences and meeting their needs. Currently, we have faced with new paradigms that are changing the social representations around people without disabilities and showing that they can ok participatory and able, provided they are propitiated conditions, respect and appreciation of their differences and they are offered opportunities. for both the proposed including society contains, implicitly, the idea of mobilizing the various social groups in the pursuit of well-being. However, it is necessary intrinsic transformations, breaking up crystallized and excluded barriers, becoming subjects of their own history. from this perspective should ok the idea of appreciation and respect for human diversity, where inequality and all forms of exclusion are repudiated guaranteeing, everyone access to goods and services of social life. The role of education is of fundamental importance, as they are highlighted and hired the school's commitment to all and for all.


Objective To observe the renal tubular epithelial cells transdifferentiation and the effects of Losartan on streptozotocin-induced diabetic rats,explore the renal protective mechanisms of ARB in DN.Methods Fifty Wistar rats were randomly divided into three groups:(1) Normal control group without streptozotocin-induced diabetes and without therapy(n=10);(2)diabetes without therapy group(n=20),(3)diabetes therapy group with Losartan 20 mg/Kg ·d~(-1)(n=20);Rat models of diabetic mellitus were established by intraperitoneal injection of 60 mg/kg streptozotocin.At sixteen weeks after therapy with Lorsartan,The alpha smooth muscle actin(α-SMA),vimentin and transforming growth factor-β1(TGF-β1)in renal tubular epithelial cells were detected by immunohistochemistry of SP method.Results The positive areas of α-SMA,vimentin and TGF-β1 in renal tubular epithelial cells of diabetic group were 0.3690±0.0587,0.1546±0.0141 and 0.3716±0.0657 respectively,showed stronger passivity in comparison with Lorsartan therapy group(P0.01).Conclusion Losartan can down-regulate expression of α-SMA,vimentin and TGF-β1 in diabetic renal tubular epithelial cells,restrain the process of epithelial myfibroblast transdifferentiation in diabetic rats.


Drug-eluting stents(DES) have dramatically reduced the rates of restenosis and target lesion revascularization compared with bare-metal stents(BMS).However,a low rate of in-stent restenosis(ISR) after DES still exits,and its prevalence is not negligible because the population treated with DES is large.The treatment of patients with BMS ISR has been extensively studied.Conversely,the data on therapeutic options in patients with DES ISR remain scarce and the optimal treatment remains undefined.Based on the results of many studies recently reported,we ought to give a concise,comprehensive overview of the management options of DES ISR.


The trade organizational model from the competitive advantage thought of Michael Porter and the enterprise resource based model from the core competitive power thought of Gary Hamel are the tools of enterprise strategic management. Though both state the strategy of the company from the behavior respect of strategy, they have great differences. Only the strategic structures designs based on the enterprise resource based model can make the enterprises' strategic behaviors into effect around key competitive power.


In laboratory animals papaverine acts as a potent coronary vasodilator drug. 1 Studies 2 indicate that ethaverine (6,7-diethoxy-1-[3,4-diethoxybenzyl] isoquinoline), the ethyl analogue of papaverine, is a general visceral and vascular spasmolytic agent. In recent experiments concerning the coronary blood flow of quickly isolated, beating rabbit hearts, ethaverine has been shown to be equal to papaverine in peak potency but of more durable action, so that in total effect summed up over time it is more effective. 3 Ethaverine has the advantage of not being classified as a narcotic under the Harrison Act. 4 The toxicity of ethaverine is roughly one-third that of papaverine, and large doses have been given in man without untoward effect. In a previous study, 5 16 patients with relatively stable angina pectoris were given ethaverine over periods of 4 to 20 weeks, followed by placebo therapy for corresponding periods. Seven of these 16 patients experienced marked


Osteosarcomas from dogs were inoculated subcutaneously into mice. Sixty days later six mice had tumors that gradually increased in size. All tumors were undifferentiated sarcomas. Karyotypes of osteosarcomas grown in tissue culture and of tumors from mice inoculated with the culture were similar with two marker chromosomes. It was thus shown that radioinduced osteosarcomas can be cultivated in tissue culture while retaining their marker chromosomes and malignancy. (HLW)


When Japan was invading China,it considered MengJiang as "Special District Watching out for CCP" and ordered it to oppose CCP and keep away U.S.S.R(Union of Soviet Socialist Republics).So the MengJiang regime began its activities opposing CCP,besides implementing military activities and strengthening public security,it also carried through propaganda,education and religious activities to oppose CCP.Japan attemped to cheat and palsy the people of MengJiang through these activities.


There exists a class of decentralized discrete-event control problems where a control solution could be realized if additional events were incorporated into the description of the plant to disambiguate undesirable behaviour from legal behaviour. A state-based knowledge model for the analysis of such control problems is introduced. A communication protocol is used to motivate a possible methodology for identifying states in the plant where the introduction of additional events would produce a control solution.


In this study, The criteria for assessing the security-related functions and services using spatial information is deduced, and orders of priority a priority for the applicable alternatives of functions/services of intelligent security service application based on spatial information are suggested by calculating relative importance. Also this study suggested connection plan about service implementation of national security services by government ministry & local government. And, the intelligent security app service model which has possible substantiation and commercialization is proposed. This study performed the AHP as the final assessment criterions by 3 item in 1st class and 12 item in 2nd class. And, tried to implementation methods of the intelligent security service application(ex. control of emergency and the crime opportunity, real-time location tracking of protector, the device for missing child & dementia patient, user participation & provision of information).


In this paper, we provide a survey of prominent work carried out in the intersection between Natural Language Processing (NLP) and Lexicography by the TALN Natural Language Processing group, at Pompeu Fabra University in Barcelona (Spain). First, we focus on Lexicography for NLP, i.e. taking advantage of lexicographic resources in tasks such as lexical semantics and lexical taxonomy learning. Second, we cover the area of NLP for Lexicography, where we tackle current and past projects where NLP techniques are applied to ease up the lexicographic process. This includes, generally, the automatic acquisition of lexicographic items such as textual definitions, hypernyms or collocations from naturally occurring text.


We report generation of 80-Gb/s RZ-OOK signals using a hybrid photonic integrated electroabsorption device. We achieve this using electronics having a bandwidth of 40 GHz or less and without using an external optical pulsed source.


Dear Editor, Felty syndrome (FS) is a rare complication of rheumatoid arthritis (RA) characterized by neutropenia and splenomegaly, although splenomegaly is not always present.1,2 Owing to neutropenia, FS patients are at increased risk of recurrent bacterial infections, especially in the skin and respiratory tract.1,3,4 We report a case of FS in a patient with undiagnosed RA presenting with multiple cutaneous abscesses. A 75yearold man was admitted to our hospital with fever. Physical examination revealed fluctuating erythematous nodules/ indurations with ulceration on the back and left hip (Figure 1a,b). He had not been aware of the cutaneous lesions until the examination. He had swelling and deformity of multiple (>10) small joints of the hands and feet (Figure 1c). However, he claimed that he had never had joint pain or stiffness and did not remember the onset of arthritis. Laboratory tests showed elevated Creactive protein (CRP) of 15.63 mg/dL, decreased white blood cell count of 2100/μL with an absolute neutrophil count of 649/μL. Large granular lymphocyte count (144/μL) was not increased. Rheumatoid factor (342 IU/mL) and anticyclic citrullinated peptide antibody (37.4 U/mL) were positive, but antinuclear or antiSSA/Ro antibodies were negative. He did not have diabetes mellitus. Culture of abscess material yielded methicillinsusceptible Staphylococcus aureus and Streptococcus dysgalactiae subsp. equisimilis, and the former was also detected in blood cultures. Erosive changes of the small joints were confirmed by radiographic imaging (Figure 1d). Splenomegaly was not apparent by computed tomography (Figure 1e). Based on these findings, we made the diagnosis of FS. Incision and drainage of the abscesses and i.v. administration of cefazolin resulted in improvement of general condition and cutaneous lesions within 2 weeks, but neutropenia persisted and CRP was not normalized. After confirmation of negative blood cultures and absence of other infectious foci, oral prednisolone 30 mg daily was started. Rapid increase of neutrophils was achieved, and oral methotrexate 4 mg weekly was commenced 2 weeks after the initiation of prednisolone. Prednisolone was tapered to 12.5 mg daily, and he was discharged 8 weeks after the admission with normalized neutrophil count (4774/μL) and CRP. Felty syndrome usually affects seropositive RA patients, 55– 65 years old, with longstanding (10– 15 years) disease.1,3,4 In most patients, joint destruction is severe despite mild or absent synovitis.1,3 Therefore, the diagnosis of FS as the first manifestation of RA is uncommon. The most important differential diagnosis of FS is Tcell large granular lymphocytic leukemia associated with RA and neutropenia (pseudoFS).1,4 As both FS and pseudoFS are strongly associated with HLADR4, however, they may be part of the same disease spectrum.1,2,5 Methotrexate is generally used as the initial treatment for FS.1 As methotrexate can cause bone marrow suppression, we used prednisolone before starting methotrexate. However, longterm use of corticosteroids should be avoided because of the risk of infection. Granulocyte colonystimulating factor is used for patients with severe neutropenia. Efficacy of biological and targeted synthetic diseasemodifying antirheumatic drugs has not been established. At present, splenectomy has limited indications. Felty syndrome should be included in differential diagnosis of neutropenia associated with cutaneous bacterial infections.


A succession of 16 palynological assemblages, based on spores and pollen, dinoflagellate cysts and palynomorphs of uncertain origin is recognized in Triassic (Griesbachian-Rhaetian) sequences of the Barents Sea area. This succession is based largely upon the study of material from outcrops in Spitsbergen and Bjornoya and from boreholes in the Barents Sea. The two youngest assemblages (Late Norian and Rhaetian) are recognized partly on the basis of published records. Early and Middle Triassic assemblages occur in ammonite-dated beds. Almost no independent dating of Late Triassic beds exists in Svalbard, and the age of the Late Triassic assemblages are based upon palynomorph ranges known in the Germanic and Alpine realms. Long-distance correlation using palynomorphs is limited by climatic and environmental factors. Assemblages from the Boreal realm differ considerably from those from the Germanic and Alpine realms. Assemblages from independently dated sections show that some palynomorphs have different ranges in the Arctic, whereas the ranges of others correspond in both areas. Some species seem to appear first and to have evolved in the Boreal realm. Ten microfaunal assemblages consisting of foraminifera, ostracodes and other microfossils are recognized in the Early and Middle Triassic sequences. These assemblages correspond to changes in environment and biofacies but can be used for regional correlations. Conodonts found in these associations allow correlation with the standard conodont zonation of the Triassic.


This paper is a preliminary study reporting on the results of experiments to take advantage of interband correlation between images from the GOES-West satellite. Experiments primarily focus on attempting to improve the prediction of pixel intensities using information between images in a close time sequence. We apply the use of motion vectors, linear and nonlinear predictors, as well as context modelling. Initial results show some promise, but more study is needed.


Submitted for the DAMOP11 Meeting of The American Physical Society Superradiance in spin-J atoms: Effects of multiple atomic levels GUIN-DAR LIN, SUSANNE YELIN, University of Connecticut, ITAMP HarvardSmithsonian Center for Astrophysics — We study the superradiance dynamics in a dense system of atoms each of which can be generally a spin-J particle with J an arbitrary half-integer. Using a novel formalism we derive an effective two-body master equation to study the relevant cooperative and collective effects, taking into account the coherence of transitions between different atomic levels. One direct application of such calculation is to study the superradiance, in the context of polar molecules, due to transitions between multiple excitation levels, e.g. vibrational modes. Guin-Dar Lin University of Connecticut, ITAMP Harvard-Smithsonian Center for Astrophysics Date submitted: 07 Feb 2011 Electronic form version 1.4


This book provides the key for teachers using North and Hillard's classic text, "Latin Prose Composition," which has been in use throughout the world for over 100 years. The book provides the answers to the English to Latin composition exercises given in the textbook.


Medulloblastoma has been categorized into four subgroups based on genetic, epigenetic and transcriptional profiling. However, molecular pathways determining radiotherapy response in this tumor remain elusive. Here, we investigated the role of the EZH2-dependent histone H3K27 tri-methylation in radiotherapy response in medulloblastoma. We demonstrate that 47.2% of group 3 and 4 medulloblastoma patients have H3K27me3-deficient tumors. Loss of H3K27me3 was associated with a radioresistant phenotype, high relapse rates and poor overall survival. We show that an epigenetic switch from H3K27me3 to H3K27ac occurs at specific genomic loci in H3K27me3-deficient medulloblastoma cells altering the transcriptional profile. The resulting up-regulation of EPHA2 (ephrin type-A receptor 2) stimulates an excessive activation of the pro-survival AKT signaling pathway leading to radiotherapy resistance. We show that BET inhibition targets radiation resistance in H3K27me3-deficient medulloblastoma by suppressing H3K27ac levels, blunting EPHA2 overexpression and mitigating the excessive AKT signaling. Additionally, BET inhibition sensitizes medulloblastoma cells to radiation by enhancing apoptotic response through suppression of Bcl-XL and up-regulation of Bim expression. Our work demonstrates a novel mechanism of radiation resistance in medulloblastoma and identifies an epigenetic marker predictive of radiotherapy response. Based on these findings we propose an epigenetically guided treatment approach targeting radiotherapy resistance in medulloblastoma patients.


L. monocytogenes is a Gram-positive, nonsporeforming, facultatively anaerobic bacterium. It is widely spread in nature; in soil, plant, sewage, silage, slaughterhouse waste, dust and even water [1]. It has been found in at least 37 mammalian species, both domestic and wild, as well as in at least 17 species of birds and possibly some species of fish and shellfish. Humans (1–10 %) may be intestinal carriers of L. monocytogenes. L. monocytogenes is present in a wide variety of foods. The natural exposure of vegetables, fruits, grains, food for animals, fish and poultry to the environmental sources of the organism makes impossible for such foods to be produced free from L. monocytogenes. L. monocytogenes is quite hardy and resists the deleterious effects of freezing, drying and heat remarkably well for a bacterium that does not form spores. Even normal refrigeration temperature (between 0 and 8 oC) does not kill it. The main growth-limiting parameters for L. monocytogenes are temperature (minimum –0,4 oC, maximum 45 oC) pH (minimum 4.39, maximum 9.4) and water activity (minimum 0.92). The bacterium does not change the taste or smell of contaminated food, which is the most frequent source of human infection with L. monocytogenes. For these reasons, it can be very difficult to suspect or trace the source of a listeria outbreak.


The present study estimates profitability of MV Boro rice production under shallow tubewell irrigation system. The study was conducted in Ghatail upazila of Tangail district. In the study, 60 water buyers from 5 villages were randomly selected. The survey covered a whole period of MV Boro production (January to May 2008). The major findings of the study were that about one third of total cost shared by irrigation charge. Though, the water buyers made a significant profit from MV Boro paddy production but the buyers were not fully satisfied with the prevailing one-fourth water charge and claimed for reduction of water charge. Education and farming experience was the important tools to increase profit in MV Boro paddy production. A considerable further scope apparently exists for expansion of STWs by reducing water charge to enhance the productivity of MV Boro paddy and to increase farm income of water buyers. DOI: http://dx.doi.org/10.3329/pa.v20i1-2.16877 Progress. Agric. 20(1 & 2): 237 – 244, 2009


Background: According to the Montreal Classification, upper gastrointestinal tract phenotype L4 is uncommon in Caucasian patients with Crohn's disease (CD) but carries excess risk of recurrence. We studied the clinical course of CD in Chinese patients presenting with the L4 phenotype and factors predicting its occurrence upon longitudinal follow‐up. Methods: This prospective cohort study included 132 Chinese CD patients (median age at diagnosis, 30.0 years, range: 14.0–77.0 years) who were followed for 770 person‐years. Demographic data including disease behavior and location, details of surgery, and hospitalization were collected. The Kaplan–Meier method was used to estimate the probabilities of further hospitalization and major surgery followed by Cox proportional hazards regression to determine if clinical variables independently predicted the endpoints. Results: The L4 phenotype was found in 30 (22.7%) patients at presentation. There were significantly more stricturing (46.7% versus 18.6%) and penetrating (30.0% versus 3.9%) phenotypes in the L4 group than in the non‐L4 group (P < 0.0001). The 3‐year cumulative probability of further hospitalization was 86.9% (95% confidence interval [CI]: 73.8%–100.0%) in the L4 group as compared with 49.3% (95% CI: 39.3%–59.3%) in the non‐L4 group (log‐rank test, P < 0.0001). The L4 phenotype independently predicted further hospitalization (adjusted hazards ratio [HR]: 2.1; 95% CI: 1.3–3.5). The cumulative probability of major surgery was significantly higher in the L4 than in the non‐L4 group (P < 0.0001). Eighteen (17.6%) patients developed the L4 phenotype on follow‐up and the stricturing phenotype predicted its occurrence (adjusted HR: 5.5; 95% CI: 2.2–14.0). Conclusions: Chinese CD patients more often had the L4 phenotype, which predicted the need of subsequent hospitalization. (Inflamm Bowel Dis 2008)


Project management is gaining traction in IT organizations and the results are encouraging. Failure rates are down, costs are down, and success rates are up. Large companies are taking a small approach to project management. Minimizing means scaling down features/functions along with minimizing scope. IT organizations are adopting standard project methodologies or building enterprise-level formal project management disciplines. This level of activity is quite a change.


Variational segmentation methods have been intensively studied. Tra-ditionally, the Euler-Lagrange equations are solved by some iterative numerical methods. Normally, the speed is slow. In this work, the piecewise constant level set method (PCLSM) is used for the multiphase Mumford-Shah segmentation model. Instead of solving the Euler-Lagrange equations, we propose to solve the resulting minimization problem by graph cuts, a combinatorial optimization technique. By finding the minimum cut on a special graph, we obtain the solution for the segmentation problem. Numerical experiments show that the new approach is very superior in terms of efficiency, while maintaining the same quality of results.


China University Basketball Association (CUBA) has good effects on campus culture. It plays a positive role in enhancing the university coherence, the sense of honor, social responsibility, team spirit and patriotism.


This study examines the relationship between the political connection and tax avoidance in all Jordanian market companies, the relationship between accounting information quality and tax avoidance, and the moderating effect of accounting information quality between the political connection and tax avoidance relationship. The sample data of the study includes 206 companies, with a total of 2266 observations from the period from 2008 to 2018. The results indicated that the political connection positively correlates with tax avoidance, which is supported (Jensen & Meckling, 1976). The results of this study also indicated a significant negative association between accounting information quality and tax avoidance. Moreover, the moderating effect of accounting information quality on the political connection and tax avoidance relationship indicated a significant negative association with tax avoidance. Thus, the study supported the agency theory that governance mechanisms such as accounting information quality function led to the reduction of agency problems and reduce information asymmetry. The study finding supported Ward et al.'s (2009) argument and suggested that accounting information quality plays a substitute role rather than a complementary role in mitigating the agency problem. The outcomes of this study could assist the policymaker and companies in the importance of accounting information quality in disciplining political involvement in the Jordanian market.


Abstract. Correlation of ionized calcium concentration, [Ca2+] and blood pH has long been recognized. So far no distinction of the acid‐base changes, i.e. respiratory changes or metabolic changes seemed necessary. The present study, with the use of a recently developed system for in vivo analysis of [Ca2+], and with in vitro experiments reinvestigates this question.


Objective: In the present investigation, contraceptive efficacy of neem seed oil and its fractions have been examined in female albino rabbits to find out their contraceptive potential.Methods: The experimental protocol was designed for intact control, Neem seed oil alone and its six active fractions in eight groups for 30 days. The estimation of serum biochemistry, histometry of reproductive organs, and hematological parameters were done.Results: Oral administration of Neem seed oil alone and its Fraction IV and V causes significant reduction in weight of ovary and uterus which reflects antiestrogenic function of plant material. Significant increase in serum cholesterol and phospholipid in Neem seed oil alone and its Fraction IV and V-treated groups reflects that they may affect the intraovarian estrogen level either by inhibiting the ovarian cell function or by inhibiting follicle-stimulating hormone and luteinizing hormone secretion through hypothalamus-hypophysis axis and impaired estrogen synthesis.Conclusion: From the ongoing work, it can be concluded that Neem seed oil alone and its Fraction IV and V cause functional sterility in female albino rabbits without causing any side effect on general metabolism.


This article introduces the hardware and software design approach based on single chip microcomputer of MCS-51 series to control SA8282 to drive IGBT,in order to generate the AC pure sinusoid on the basis of static-inverter.This means is more accrate than conventional means.The characteristic of new system is suprior in structure simplifation,machine time, real-time responcibility etc, to traditional system.The reliability of the system is enhanced.


The Fama French Three Factors model is one of the most common financial models used to predict portfolio returns. In my research, I add one more element, EV/EBIT, to test whether the value of EV/EBIT might influence the accuracy of the Fama French three factors Model. As a result, EV/EBIT doesn't explain by the Fama French Three Factors Model. Companies with low EV/EBIT tend to get lower alpha than companies with high EV/EBIT, implying that EV/EBIT affects the accuracy of the Fama French Three Factors Model.