In this note we consider a simple example of a finite dimensional system of stochastic differential equations driven by a one dimensional Wiener process with a drift, that displays some similarity with the stochastic Navier-Stokes Equations (NSEs), and investigate its ergodic properties depending on the strength of the drift. If the latter is sufficiently small and lies below a critical threshold, then the system admits a unique invariant probability measure which is Gaussian. If, on the other hand, the strength of the noise drift is larger than the threshold, then in addition to a Gaussian invariant probability measure, there exist another one. In particular, the generator of the system is not hypoelliptic.


in Selected East Asian Countries Hiroyuki TAGUCHI Abstract Exchange rate management is one of the central issues of macroeconomic policies. Since the postwar period, there has been a long-term debate over the merits of fixed versus floating exchange rates. The debate, which is typically framed in terms of the trade-off between credibility and flexibility, has gone through several swings of the pendulum. Recently, the debate on exchange rate regimes has become focused on whether or not the intermediate regimes such as target zones, crawling and basket pegs are vanishing, in other words, whether or not exchange rate regimes are moving to a corner solution with the "hard peg" or the "free float". So far, no clear consensus has been reached. The 1997-98 Asian crises have refocused attention on exchange rate management of East Asian countries. Most views expressed criticize the pre-crisis US dollar-pegged-rate regime as one of the causes of the crisis. It is said that this regime induced short-term external overborrowing and caused the appreciation of real exchange rates with the loss of competitiveness. The question also arises as to whether, after the crisis, the East Asian countries are simply returning to the pre-crisis US dollar standard, or whether they have learned a lesson from the crisis and are finding another path to follow. This article focuses on the exchange rate management of the selected East Asian countries, evaluates the pre-crisis dollar peg system from the viewpoint of such external balances as capital flow and trade, and examines the post-crisis exchange rate management. The main findings are as follows: 1) the dollar peg system had induced massive capital inflows through significantly large super risk premium against the US; 2) the dollar peg system had deteriorated trade balances through significantly large appreciation of real effective exchange rate; 3) as an alternative exchange rate management, the inflation-slid management, rather than the basket pegging, had been more preferable than the simple dollar peg system from the viewpoints of stabilizing both capital inflow and trade balance; 4) in the post-crisis exchange rate management, some East Asian countries have come to care more about the factor of the inflation slide in addition to the US dollar linkage. We speculate that they may have learned the lessons that the Asian crisis was partly caused by the simple US dollar peg regime accompanied by massive capital inflows and worsening trade balance. The strategic implication of the findings is the importance of inflation slide in the exchange rate management in the emerging East Asian economies.


This paper presents a new analytical solution for undrained expansion of spherical and cylindrical cavities in soils with a unified state parameter model for clay and sand (CASM). Large strain and effective stress solutions are derived for soils in the elastic, plastic and critical-state regions. The key advantage of using the state parameter model CASM is that it can model both clay and sand and is generally able to capture overall soil behaviour as observed in the laboratory. The newly developed solution provides the stress and strain fields during the expansion of a cavity from an initial to a final radius. Following the validation with the original Cam Clay solution, a simple parametric study is conducted to investigate the effects of key model parameters on stress distributions and cavity expansion curves. Applications to the analysis of pile installation and self-boring pressuremeter tests highlight some important implications in geotechnical practice.


The objective of this study was to determine the acidification of precipitation in the Jeju area. Precipitation samples were collected from the Jeju area from 2009-2014, and the major ionic species were analyzed. In the regression analysis, through a comparison of ion balance, electric conductivity, and acid fraction, the correlation coefficients showed a good linear relationship within the range of 0.927~0.983. The volumeweighted means of the pH and electric conductivity were 4.9 and 22.7 μS/cm, respectively. The ionic strength of precipitation was 0.27±0.38 mM, indicating about 35.9 % of total precipitation within the pure precipitation criteria. The volume-weighted mean concentrations (ieq/L) of the ionic species in the precipitation were in the order of Na+ > Cl− > nss-SO₄ 2− > NO₃− > NH₄+ > Mg 2+ > H+ > nss-Ca 2+ > PO₄ 3− > K+ > HCOO− > CH3COO−> NO₂− > F− > HCO₃− > CH₃SO₃−. The acidification contributions by sulfuric and nitric acids were 54.5 % and 36.5 %, respectively. Meanwhile the acidification contributions by formic and acetic acids were 4.8 % and 4.2 %, respectively. Thus, it was found that the acidification of the precipitation in the Jeju area was mainly due to the inorganic acids. The neutralization factors by NH3 and CaCO3 were also 33 % and 20 %, respectively.


A high-performance DC-DC converter that has good DC characteristics and operates on constant-frequency, variable-duty mode in a wide load range is proposed. It also has low switching loss, low voltage stress, and low electromagnetic interference. Owing to these features, the converter overcomes most of the limitations of resonant and quasi-resonant converters, such as high VA rating of resonant elements, variable frequency operation, and limited load range, and improves on the efficiency and DC characteristics of the pseudo-resonant converter. The proposed converter is thought to be suitable for high-power applications (above several kVA) as well as for low-power applications with high power density and high performance. Simulation results are shown under the conditions of 100 kHz and 1 kVA load.<<ETX>>


This paper presents a systematic literature review of learning analytics dashboards (LADs) research that reports empirical findings to assess the impact on learning and teaching. Several previous literature reviews identified self-regulated learning as a primary focus of LADs. However, there has been much less understanding how learning analytics are grounded in the literature on self-regulated learning and how self-regulated learning is supported. To address this limitation, this review analyzed the existing empirical studies on LADs based on the well-known model of self-regulated learning proposed by Winne and Hadwin. The results show that existing LADs are rarely grounded in learning theory, cannot be suggested to support metacognition, do not offer any information about effective learning tactics and strategies, and have significant limitations in how their evaluation is conducted and reported. Based on the findings of the study and through the synthesis of the literature, the paper proposes that future research and development should not make any a priori design decisions about representation of data and analytic results in learning analytics systems such as LADs. To formalize this proposal, the paper defines the model for user-centered learning analytics systems (MULAS). The MULAS consists of the four dimensions that are cyclically and recursively interconnected including: theory, design, feedback, and evaluation.


may be constrained by the maximum available supply of savings. Foreign aid supplements this and enables a faster pace of economic development. Second, in the initial stages of development an underdeveloped country may require several goods of strategic importance that it is unable to manufacture domestically because either skills or raw materials are lacking. In addition, the export earnings may not be adequate to purchase such goods from abroad. Lack of foreign exchange, therefore, slows up the economic development process. In this context foreign aid overcomes the import constraint. It has been suggested that the development process can be accelerated when the foreign-exchange constraint is removed, compared with the savings constraint. A major assumption of Chenery's "two-gap model" is that the ex ante savings gap and the foreign-exchange gaps are independent of one another. This assumption has been the subject of critical analysis. It has been argued that the balance-of-payments problem cannot be treated in isolation from the savings-investment problem. Alfred Maizels has argued that variations in exports might result in associated variations in domestic savings.2 Should this be correct, the two-gap * I am indebted to Professor David Felix for his encouragement in exploring the main hypothesis of this paper. He is not responsible for any errors in the analysis. I am thankful to two anonymous referees of this journal for helpful comments on an earlier draft of this paper. I am also thankful to Ling Ling Chang for help with the computer work.


AIM To develop a sensitive method for detecting condensed tannin in herb injections.METHODS Polyvinylidene fluoride(PVDF) membrane coated with protein was installed on a filtering device with holes of 2 mm in diameter.The solution sample was filtrated through the PVDF membrane.The membrane was washed with methanol or other organic solvents to remove the stained color not caused by condensed tannin.The blot color intensity in the membrane was related to the condensed tannin content in the sample.RESULTS The detection limit of this method was about 0.07 mg/mL of condensed tannin in 0.5 mL sample.The method was able to keep from interference caused by other color components not from condensed tannin.The method even detected condensed tannin in four herb injections(Qingkailing Injection,Shuanghuanglian Injection,Danshen Injection and Dengzhan Xixin injection) from the market.CONCLUSION The results suggested that the method be useful to control condensed tannin in Chinese materia medica injections.


Preface United States Relations with the Association of Southeast Asian Nations (ASEAN) U.S. Accession to the Association of Southeast Asian Nations' Treaty of Amity & Cooperation (TAC) ASEAN: Regional Trends in Economic Integration, Export Competitiveness, & Inbound Investment for Selected Industries Index.


Nuclear techniques of analysis such as Perturbed Angular Correlation (PAC) spectroscopy and Nuclear Magnetic Resonance of Oriented Nuclei (NMRON) are well established for the study of structural and magnetic properties of crystalline materials. In both techniques a radioactive isotope is introduced into the material as a probe. Radioactive decays of the probing nuclei may be detected to extract information about local electric and magnetic fields and study, for example, structural properties of the host material or annealing processes. While diffusion is a common method to introduce radioactivity to host materials, with ion implantation the number of introduced nuclei can be controlled explicitly and is not affected by physical properties of the host material as is the case for diffusion. The use of negative-ion implantation has the added advantage that negative ions can be produced abundantly for most elements. Recoil implantation of energetic radioactive ions is routinely used in Canberra, however, structural damage to crystals is often severe. The direct implantation of radioactivity at low energies would minimize such damage and improve the efficacy of NMRON and PAC studies. A low energy ion implanter to facilitate such work is currently under development in the radiation laboratories (of the University of New South Wales) at the Australian Defence Force Academy.


The invention discloses a three-dimensional digital particle image generation device and a three-dimensional digital particle image generation method based on excitation suction. An imaging module and a sucking module of the device are arranged on the same side of a light-transmitting piece. The light-transmitting piece is arranged on the upper surface of a flow pass and is positioned in a magnetic field generated after electrification of the center of a light path of the imaging module and the sucking module. The sucking module sucks particles to the lower side of the light-transmitting piece. The imaging module is provided with a focusing mechanism used for adjusting focus to acquire images with different focal planes. An image processing module is used for dividing focal plane ranges of the images with the different focal planes through different difference operators and wavelet image processing, measuring three-dimensional surfaces of magnetic particles according to a morphological processing method and overlapping the images with the different focal planes through Boolean algebra operation to recreate a new particle image. The particles are sucked on the same plane by the sucking module, the images with the different focal planes are acquired to be synthesized, and the clear and stable three-dimensional digital particle image is generated.


Introduction 1. London's first stock market boom 2. The rise of the public funds 3. The contemporary debate 4. The development of a financial press 5. Networks of information 6. The investors 7. Stock-jobbing the market 8. Investment strategies Conclusion Appendices Bibliography.


This paper points out the existing disadvantage of intramural productive training base,elaborated the construction mode of logistics management professional intramural productive training base in Guangzhou Vocational College of Technology Business.Introduces the training base of the operation,analyzed the training base of the operation result,gives the direction of future efforts,undertook good practice and exploration on the logistics management professional intramural productive training base.


The radar back-scattering cross section of the carbonfiber is calculated in this paper.The carbon fiber's crosssection is less than metal fiber's.The carbon fiber canreduce the scattering of the magnetic wave.


We learn two consequences of the Pythagorean Theorem in our earliest school years: (1) The diagonal of the square with edge length 1 has length √ 2 since 1+1 = ( √ 2). (2) There is a right triangle with edge lengths 3, 4, and 5 since 3 + 4 = 5. Coupled with a proof that √ 2 is not a rational number, the first of these consequences forced the Greeks to conclude that rational numbers are an inadequate basis for describing geometric lengths. This realization initiated a complete transformation in the way mathematicians viewed numbers and the relationship between geometry and algebra. Are there other irrational numbers? Are there more irrational numbers than rational numbers? How do we prove that a given number is irrational? The second of these consequences raised an obvious question in number theory: Are there other integer Pythagorean triples (a, b, c) such that a + b = c? If so, how do we find them? Can we list them all? In this section, we first give two proofs that √ 2 is irrational, then we show how geometry can be used to describe all possible Pythagorean triples. We also indicate how Pythagorean triples can be generalized to Pythagorean n-tuples.


n Ecuador, generates about 60,000 ton of coffee residues [1] and this figure increases annually, leading to environmental pollution [12]. This thesis focused on determining the possibility of using these residues as a source of minerals, in order to be used in food fortification. We analyzed potassium (K), calcium (Ca) and magnesium (Mg) by atomic absorption spectrophotometry and phosphorus (P) by visible spectrophotometry, using in all cases the acid digestion for sample preparation. These minerals were selected for their nutritional importance and majority concentration in coffee [14]. We worked with samples of coffee "Coffea arabica L. variety typica" of three places: Palanda, Vilcabamba and the Pangui, selected for their availability and geographical conditions. In order to maintain the traceability of waste was made the processing of the cherry coffee. The results for the pulp expressed on a dry basis were: K 2,8 ± 0,43%; Ca 0,41 ± 0,06%; Mg 0,13 ± 0,01% and P 0,12 ± 0,01 %. To parchment: K 0,15 ± 0,02%; Ca 0,13 ± 0,05%; Mg 0,07 ± 0,01% and P 0,02 ± 0,01%. Moreover, in addition, we examined the coffee bean obtained K 1,5 ± 0,09%; Ca 0,12 ± 0,02%; Mg 0,21 ± 0,02% and P 0,34 ± 0,06%. Comparing these results with the concentration in shell woolly; font used to enrich a peach nectar [39], we mention that the coffee pulp is a good source of potassium (especially), magnesium and phosphorus. The scroll is considered as a source of phosphorus.


The article expounds growth mechanism in different perspectives and based on problems in Jiaozuo cooperatives,proposed countermeasures such as building human capital in rural areas,and strengthening government support,create favorable external environments.


and oxygen transfer factor may limit exercise capacity in disease. This relationship has been explored in 11 normal subjects, 18 patients with sarcoidosis, and eight patients with interstitial lung disease by varying the inspired 02 concentration at standard work loads and following the arterial 02 saturation by means of an ear oximeter. In normal subjects the relationship between inspired P02 or alveolar Po2 and arterial saturation is a curve of increasing steepness at lower 02 pressures. In all but one of the patients with sarcoidosis a curve indistinguishable from normal was found. The radiographic appearances in these patients ranged from hilar gland enlargement to diffuse changes in the lungs. In all the patients with interstitial disease, the curve was displaced to the right, and it was possible in six patients to determine the increase in inspired Po2 necessary to maintain the resting 02 saturation unchanged. This procedure may provide the basis for a simple bloodless test for the detection of the onset of impairment of oxygen transfer in disease.


A duplication-deletion random graph is presented in this paper to model social networks which change over time. The paper analyzes the dynamics of this duplication-deletion random graph where at each time instant, one node can either join or leave the network. A degree distribution analysis is provided for this graph and an expression is derived to compute the power law component. Also a Markov-modulated random graph is analyzed where the the growth of the network evolves according to a slow Markov chain. An upper bound is derived for the mean square error between the estimated degree distribution and the asymptotic one. Using the fact that the duplication-deletion graph satisfies a power law, an upper bound is presented for the most significant singular value of the adjacency matrix of the graph.


A plant species is infected by handful of pathogenic organism despite the fact that it is constantly exposed to innumerable pathogens. The chemical anti-bio agents exploited against these pathogens were harmful to environment and human health as well. So the only alternative way is to grow disease resistant varieties of crops by introducing resistant (R) genes. However, new pathogenic races evolve constantly and are notorious for their ability to withstand race specific resistance mediated by R-genes . Plants deploy robust, broad-spectrum and durable resistance mechanisms called nonhost resistance (NHR) against most pathogenic organisms. Such disease resistance mechanisms are nonspecific and effective against all nonhost or non-adaptive pathogens. The NHR defence response includes production of phytoalexins and other antimicrobial compounds, hypersensitive response by rapid localized cell death, deposition of callose and expression of pathogenesis related genes at the site of infection that restricts further growth of pathogen. Although NHR has immense potential to improve crop production in agriculture, very little is known about the mechanism of NHR and its genetic pathways at molecular level. Detail knowledge about the NHR genes from a nonhost plant and engineering the NHR gene into the host plant will be helpful in making broad-spectrum and durable disease resistant crops. In this mini review, we report the list of NHR genes and their function against various phytopathogens. We further report a method to identify or map putative NHR gene/s in Arabidopsis against soybean pathogen Phytophthora sojae nonhost with a goal to improve disease resistance in crop species.


The ORR operated at an average power level of 29.1 MW for 76.6% of the time during April, May, and June of 1982. The reactor was shut down on twenty-eight occasions, eight of which were unscheduled. Reactor downtime needed for refueling, maintenance, and checks was normal, with the reactor remaining available for use 88.4% of the time. Maintenance activities, both mechanical and instrument, were essentially routine in nature with the exception of one Reactor Instrumentation and Controls Design Change Memo.


Ascribed as skills of the 21st century or soft skills, non-cognitive skills include the '4Cs' of communication, collaboration, critical thinking, and creativity as well as persistence, resilience, and grit: requisite abilities for engineers of today and the future. This chapter presents a single illustrative experimental case study of 16 seventh grade students who designed boats using the engineering design process (EDP) and 3D mixed reality (a combination of virtual and augmented realities) to understand students' non-cognitive skill use and perceived growth. Qualitative data converged to suggest that critical thinking, creativity, and grit were the most salient skills used (observed) and developed (reported). Further, findings indicated that the MR technology (zSpace) was easy to use and helped students with enhanced 3D visualization (immersion) and control (interaction) of designs. Collaboration and communication were perceived as skills that had decreased and were less observed. This research provides insight to how MR elicits secondary students' non-cognitive abilities in STEM.


Traditional English Learning Testing has five limitations.All these conflict with the new curriculum standard.The ability of intercommunication is the most important object of language teaching and learning.We should reform English learning testing system under new curriculum standard from the perspective of objects,forms,developing process,evaluation and feedback.


The purpose of this paper is to obtain enthalpy balance and exergy analysis for the energy losses in a steam power plant. The enthalpy and exergy analysis of the steam power plant were carried out on the various output of steam turbine. While enthalpy analysis shows that circulating loss in the condenser is maximum, exergy evaluation of the power plant shows that the losses of the boiler and turbine are considerably larger than those of condenser and feed water heater. Most irreversible losses of the power plant occur at the boiler. For improving the performance, the precise study about the irreversible losses of the boiler is necessary.


The excitation transitions considered are 11S to 21P and 11S to 31P. Electron correlation is introduced into the description of the 11S ground state in a systematic way by using the natural expansion of a configuration-interaction (CI) wavefunction developed by Weiss. By truncating this expansion to the first X terms and renormalizing a series of wavefunctions ranging from a Hartree-Fock equivalent (X=1) to the full CI function (X=15) are obtained. Operating within the first Born approximation, three standard formulations for evaluating f(K) are used and their sensitivity with respect to correlation effects is discussed and a comparison of the present results is made with those of other workers. Although the inclusion of the first correlation configuration in the 11S wavefunction did not necessarily guarantee an improvement in f(K), the introduction of the second correlation term in the natural expansion gave rise to a significant improvement in f(K) for all K regardless of the mode of calculation.


Objective To investigate the changes and significance of electrical remodeling in midmyocardial (M)cells of rabbit left ventricle with chronic pressure-overload.Mothods Thirty-two new Zealand rabbits were randomly divided into constriction group and sham group. The rabbit ventricle models with chronic pressure-overload were prepared by partial constriction of superrenal abdominal aorta. At 8 weeks after operation, the single myocytes were enzymatically isolated from the midmyocardium in the antelateral free wall of left ventricle. Whole cell patch clamp technique was used to record the membrane capacitance, action potential(AP) of M cells.Results At 8 weeks after operation, compared with sham group, the membrane capacitance of M cells from constriction group significantly increased by 34.0%(P0.05). At BCL of 2s, APD90 of M cells in constriction group was 30.6% longer than that in sham group(P0.05). Furthermore, APD of M cells in constriction group presented more pronounced slow frequency-dependence and were easier to produce early afterdepolariztion(EAD). Conclusion During the early phase of chronic pressure-overload, electrical remodeling of M cells from rabbit left ventricle developed,which could be a risk factor for the occurrence of arrhythmia.


The reported likely QPO is found to be an instrumental effect, which was never clarified in any INTEGRAL related literatures. The paper should therfore be withdrawn.


Background. Many prognostic scores have been proposed for risk stratification of chronic myeloid leukemia (CML) patients: the Sokal is the oldest and the most widely used score; the EUTOS long-term survival (ELTS), based on a large cohort of patients treated frontline with imatinib (IM), is the most recent score. The ELTS score, compared to Sokal score, showed superior ability to predict overall and leukemia-related survival, but data are limited and differences were small. Further evidence is required to support and to implement the clinical use of ELTS score.
 Aims. Given the different weight of the variable "age" in ELTS and Sokal score formulations, we hypothesized a different predictive value in specific age groups. Consequently, the aim of our study was to compare the prognostic value of ELTS and Sokal scores in a cohort of CML patients treated frontline with tyrosine kinase inhibitors (TKIs), according to the age, < 30 years, 30-64 years, or ≥ 65 years old.
 Methods. Nine hundred and four adult patients were included, 559 treated with IM and 345 treated with nilotinib (NIL). Patients were enrolled in six multicenter studies (NCT00481052, NCT00769327, NCT01535391, NCT00514488, NCT00510926, observational trial CML/023) conducted by the GIMEMA CML WP. The intention-to-treat population of each study was analyzed. Definitions: major molecular response (MR3 or MMR), BCR-ABLIS <0.1%; deep molecular response (MR4), BCR-ABLIS <0.01% with > 10.000 copies; progression, transformation according to ELN criteria; leukemia related death (LRD): death after progression.
 Results. Median age, 52 years (range 18-86). Age distribution: < 30 years, 68 pts (8%); 30-64 years, 634 pts (70%); ≥ 65 years 202 pts (22%). Median follow-up 77 months (range: 24-109 years). The risk according to the two scoring systems was as follows: 57% low, 30% intermediate and 13% high ELTS score, 40% low, 39% intermediate and 21% high Sokal score, respectively; in elderly patients (≥ 65 years), 24% low, 54% intermediate and 22% high ELTS score, 9% low, 70% intermediate and 21% high Sokal score, respectively. The risk distributions were comparable in patients treated with IM or NIL. The concordance between the two scores, in particular in the low (L) and the high (H) risk categories, was good in patients < 30 years (87% L-L and 80% H-H, respectively) or 30-64 years old (68% L-L and 85% H-H respectively); in contrast, in patients ≥ 65 years old, only 8% of low ELTS patients had a low Sokal score, and only 48% of high ELTS score had a high Sokal score. Overall, both scores were able to predict significantly different probabilities of MR3, MR4, overall survival (OS) and LRD, but in elderly patients (> 65 years) only the ELTS score was able to predict the achievement of MR3 (99%, 87% and 75% in low, intermediate and high-risk patients, respectively; p=0.001) and MR4 (82%, 61% and 50% in low, intermediate and high ELTS score patients, respectively; p=0.005). Interestingly, in elderly patients both scores predicted the OS, while only the ELTS score predicted a significantly different LRD probability (cumulative incidence 2%, 6% and 14% in low, intermediate and high-risk patients, respectively; p=0.049). The results were similar considering patients < 30 years, 30-59 years, or ≥ 60 years old.
 Summary/Conclusion. The risk distribution according to ELTS and Sokal score and the concordance between the two scores was different in young adults (< 30 years), adults (30-64 years) and elderly (≥ 65 years) patients, and the number of patients potentially misclassified by the Sokal score was particularly relevant in the elderly group. In elderly CML patients treated with IM or NIL as frontline therapy the ELTS score was able to predict the achievement of MR3 and MR4 and long-term leukemia-related survival, whereas the Sokal score was not able to find any significant difference. Consequently, especially in elderly patients, the use of ELTS score is strongly recommended to assess the baseline disease-risk and to select patients candidate to a frontline treatment with second generation TKIs, minimizing the risk of unnecessary over-treatment.

 Castagnetti: Bristol Myers Squibb: Consultancy, Honoraria; Incyte: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria; Novartis: Consultancy, Honoraria. Gugliotta:Pfizer: Honoraria; Incyte: Honoraria; Bristol-Myers Squibb: Honoraria; Novartis: Honoraria. Breccia:Incyte: Honoraria; Novartis: Honoraria; BMS: Honoraria; Pfizer: Honoraria. Levato:Novartis: Other: Advisory board. Abruzzese:Ariad: Consultancy; BMS: Consultancy; Novartis: Consultancy; Pfizer: Consultancy. Soverini:Incyte Biosciences: Consultancy; Novartis: Consultancy; Bristol Myers Squibb: Consultancy. Foà:GILEAD: Speakers Bureau; JANSSEN: Other: ADVISORY BOARD, Speakers Bureau; INCYTE: Other: ADVISORY BOARD; AMGEN: Other: ADVISORY BOARD; ROCHE: Other: ADVISORY BOARD, Speakers Bureau; CELGENE: Other: ADVISORY BOARD, Speakers Bureau; CELTRION: Other: ADVISORY BOARD; NOVARTIS: Speakers Bureau; ABBVIE: Other: ADVISORY BOARD, Speakers Bureau. Martinelli:Abbvie: Consultancy; Novartis: Speakers Bureau; Janssen: Consultancy; Roche: Consultancy; Jazz Pharmaceuticals: Consultancy; Amgen: Consultancy; Ariad/Incyte: Consultancy; Celgene: Consultancy, Speakers Bureau; Pfizer: Consultancy, Speakers Bureau. Cavo:AbbVie: Honoraria, Membership on an entity's Board of Directors or advisory committees; Bristol-Myers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees; Amgen: Honoraria, Membership on an entity's Board of Directors or advisory committees; GlaxoSmithKline: Honoraria, Membership on an entity's Board of Directors or advisory committees; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees; Adaptive Biotechnologies: Honoraria, Membership on an entity's Board of Directors or advisory committees. Pane:Novartis: Research Funding, Speakers Bureau; BMS: Speakers Bureau; AMGEN: Speakers Bureau.


Detailed observations of moisture and energy fluxes made at the Boreal Ecosystem-Atmosphere Study (BOREAS) tower flux sites offer a unique opportunity for the evaluation of hydrological models, since model process representations can be compared with observations. The distributed hydrology-soil-vegetation model (DHSVM) was used to simulate the latent and sensible heat fluxes at the old black spruce and old jack pine tower flux sites in the southern study area and the old black spruce tower in the northern study area during the summer of 1994. The model did a reasonable job of simulating both the seasonal average fluxes and the diurnal cycle of the surface heat fluxes. However, a lag was observed in the simulation of the sensible heat flux, which was attributed to an inadequate representation of the ground heat flux and ground heat storage. It was also noted that direct soil evaporation forms an important part of the latent heat flux simulated by the model. Incorporation of a more complete soil thermal model, and further field work in 1996 to evaluate the importance of the moss layer and the direct evaporation from the soil, is expected to lead to further improvements.


The dynamic magnetic properties of Ni nanoparticles diluted in an amorphous SiO2 matrix prepared from a modified sol–gel method have been studied by the frequency f dependence of the ac magnetic susceptibility χ(T). For samples with similar average radii ∼3–4 nm, an increase of the blocking temperature from TB∼20 to ∼40 K was observed for Ni concentrations of ∼1.5 and 5 wt %, respectively, assigned to the effects of dipolar interactions. Both the in-phase χ′(T) and the out-of-phase χ″(T) maxima follow the predictions of the thermally activated Neel–Arrhenius model. The effective magnetic anisotropy constant Keff inferred from χ″(T) vs f data for the 1.5 wt % Ni sample is close to the value of the magnetocrystalline anisotropy of bulk Ni, suggesting that surface effects are negligible in the present samples. In addition, the contribution from dipolar interactions to the total anisotropy energy Ea in specimens with 5 wt % Ni was found to be comparable to the intrinsic magnetocrystalline anisotropy barrier.


The article reviews the reports delivered on November 1–3, 2022, at the International Research-to-Practice Conference Media Art—XXI Century: Genesis, Art Programs, Education Problems. It was organized by the Russian Academy of Arts, the Research Institute of Theory and History of Fine Arts, the State Institute for Art Studies, Stroganov Moscow State Academy of Design and Applied Arts, the Moscow Architectural Institute (State Academy), and the National Academy of Design. The conference aimed at comprehending the current state of media art in the context of digitalization of classical works and methods of their exposure; at identifying key program and aesthetic dominants in media art; and at systematizing the most relevant educational projects. The organizers suggested the following aspects as the major research focuses: classical arts and media in digital discourse; new media in the socio-cultural environment; current media forms and their genesis; new media in the urban environment; interdisciplinary and authorial projects; educational processes and new competencies. Cultural institutions today are faced with the search for a definition of materiality, with fixation of transitory art; and in response, contemporary art studies are forced to develop new theoretical concepts to be used in scholarly discourse. It is how contemporary media, digital and post-digital technologies influence the state and development of contemporary art and art history practice, architecture, design, and decorative arts, that became the key research task of Media Art—XXI Century Conference. The conference demonstrated the wide range of aesthetic, art history, culturological and pedagogical aspects, which are incorporated in the creation, exposure, and further circulation of media art in the socio-cultural space.


Abstract. In this article, we study the existence of solutions of the complex linear differential equation of the form f (n) + An−1(z)f (n−1) + ... + A1(z)f ′ + A0(z)f = 0, where the coefficients A0, A1, ..., An are analytic functions in the unit disc. To carry out the existence of these solutions, we obtain some conditions for the coefficients which grantee the existence of the solutions in QK,ω(p, q) spaces.


During the period January '04 to March'landed huge quantities of Nemipterus spp at Sassoon Docks in Trawlers .
04. (2063.55 t)The nets were operated at a depth of 35-80m for 7-day trips and 60-85m for 10-12 day trips. The fishing area was southwest off Mumbai and Ratnagiri. The total
length ranged from 50-70 mm in January'04 to 150-245
mm in March '04 catch. However, the rates declined
from Rs. 18/kg to Rs. 10/kg. The catch was disposed
off by auction. The catch was further transported to
Ratnagiri for processing into Surimi.


The Mitchell Forum exists to give an open venue to authors with ideas and thoughts on national defense and aerospace power. The series features topics and issues of broad interest and significant impact on current and emerging policy debates. The views expressed in this series are those of the author, and not necessarily those of the Mitchell Institute. By 2030, the threats facing the United States around the world will be formidable. They will have twice, if not three times, the lethality and range of today's threats. Imagine a nation roughly 300 nautical miles (nmi) by 300 nmi in size, with a coastline bristling with anti-access/area-denial (A2/AD) weaponry. Such capabilities could include modern weapons such as hypersonic cruise missiles, fifth generation fighters, air-to-air missiles with 150 nmi ranges, digital adaptive electronic warfare waveforms, and perhaps long-range (300 nmi plus) and ultra-long-range (500 nmi) surface-to-air missiles (SAMs). Potential adversaries could enhance traditional ground-basedradar detection methods with advanced passive detection systems and possibly further augment them by acoustic detection means and advanced cyber abilities. These advances would contribute to an adversary's primary goal of attacking and disabling our capabilities before we employ them. The Air Force's mission is to fly, fight, and win today and tomorrow's wars. How we accomplish this must undergo a paradigm shift. This change is an imperative not only for the Air Force, but also for all the US armed services and elements of the Intelligence Community (IC). A review of open source literature on fifth generation weapon systems (e.g., B-2A Spirit, F-22 Raptor, F-35 Lightning II) presents a common theme: near real-time information sharing on threats, targets, onboard payloads, aircraft flight dynamics, and command and control (C2) activities.1 M ITC HELL INSTUTE or erospace St ud ies No. 1 October 2015


Brick is as old as civilization itself, dating back to ancient Mesopotamia around 500 BC. The thick clay and mud deposited by the Tigris and Euphrates rivers were reinforced with straw and shaped into brick then dried in the sun. The objective of the study is to study the Health Problems faced by Brick kiln workers. Descriptive research method has been used for this study. Convenience sampling method was used to collect the data. The size of the sample is 70. The primary data was collected through questionnaire from the respondents of Salem District. For analyzing the primary data, statistical tools such as T-test, One Way ANOVA and Factor Analysis were used with the help of SPSS Software. The major finding of the study is there is no significant difference between Health Problems and the Demographic variables. Age, Gender, Educational Qualification, Occupation and Income are also affecting the Brick kiln workers in Salem District.


The authors propose an integrated packet reservation multiple access (IPRMA) protocol for transmitting both speech and data information. Different reservation mechanisms are available to transmit speech and data packets. The protocol includes a priority mechanism which ensures that speech users have greater access to idle slots since speech packets have a more demanding delay constraint. The proposed scheme is shown to provide equitable access to channel resources for both types of users in a packet radio environment, yielding improvements in overall system performance while significantly increasing data throughput compared to a system without data packet reservation.<<ETX>>


This research focused upon two problem areas in the operation of transportation systems for the elderly and handicapped. The two areas were the training of vehicle operators and the analysis of operating data. The examination of these problem areas was designed to answer the following questions: What types of training should be provided to a vehicle operator in a system designed to transport the elderly and handicapped? What are the characteristics of operating data generated by systems can this data be utilized by system management? (A)


Information systems (IS) security is traditionally seen as technically-oriented. Technologies alone, however, cannot secure an organization's information systems at an optimal level. As such, scholars have called for more research on non-technical factors that play an important role in IS security, including human, managerial, and organizational issues. This paper aims to review and synthesize those studies that have been done on non-technical issues by applying knowledge management concepts as a tool and lens. It also identifies some issues that require further research.


Hydroxypropylcellulose (HPC) and hydroryethylcellulose (HEC), spread and adsorbed as monolayers at the air/water interface, were studied using electrocapillary wave diffraction. Evidence is presented to show that monolayers formed by adsorption from solution produce surface elasticities and surface viscosities that are essentially identical to those values obtained by spread monolayers at the same surface pressure. In all studies the more hydrophobic HPC exhibited greater surface elasticity and surface viscosity than HEC. Distinct changes in these parameters occur as the surface concentration exceeds values at which extensive looping of monomer segments into the underlying aqueous phase appears to take place


Circadian rhythm of spontaneous locomotor activity, which is normally highly elevated during the dark phase of a day, diminished after ablation of the vagal nerves in rats with intact suprachiasmatic nuclei under light-dark cyclic conditions. This suggests that gastrointestinal activity affects the circadian rhythm of locomotor activity through the afferent pathway of the vagus.


With the development of communication technology, a large number of intelligent substation has been constructed, substation area protection and wide area protection technology has been widely used. Then Protection Intelligent Center (PIC) taking over the main functions of multiple substations protection in the distribution network comes into being, making large-scale information centralized processed becomes possible. Against to the problem that traditional local information-based protection is difficult to set and coordinate brought by increasingly complex distribution network, this paper redefines the partition to protection are and its search strategy, gives a fault criterion based on multi-terminal current differential protection. Finally we propose the scheme of current differential protection based on partition principle.


Objective]To study the effect of iminophylline-dexamethasone method in treating fetal distress during the second stage.[Methods]Normal primiparae who had fetal distress in the second stage were randomly selected and divided into two groups: 110 of the were in the study group treated with iminophylline-dexamethasone, 105 of them were in the control group treated with 50% glucose and vitamin C. [Results]In the study group, the recovery of fetal heart rate and fetal prongaosis were obviously higher than that of the control group, significant difference was found (P0.01). The rate of neonatal asphyxia and delivery operation were obviously lower than the control group.[Conclusion]Iminophylline-dexamethasone method is an effective method in treating fetal distress during the second stage. But the effect is not obvious in treating fetal distress caused by umbilical card oppression.


Background: Since the emergence of SARS-CoV-2, the virus that causes coronavirus disease (COVID-19) in late 2019, communities have been required to rapidly adopt community mitigation strategies rarely used before, or only in limited settings. This study aimed to examine the attitudes and beliefs of Australian adults towards the COVID-19 pandemic, and willingness and capacity to engage with these mitigation measures. In addition, we aimed to explore the psychosocial and demographic factors that are associated with adoption of recommended hygiene-related and avoidance-related behaviors. Methods: A national cross-sectional online survey of 1420 Australian adults (18 years and older) was undertaken between the 18 and 24 March 2020. The statistical analysis of the data included univariate and multivariate logistic regression analysis. Results: The survey of 1420 respondents found 50% (710) of respondents felt COVID-19 would somewhat affect their health if infected and 19% perceived their level of risk as high or very high. 84.9% had performed [≥]1 of the three recommended hygiene-related behaviors and 93.4% performed [≥]1 of six avoidance-related behaviors over the last one month. Adopting avoidance behaviors was associated with trust in government/authorities (aOR: 5.5, 95% CI 3-9.0), higher perceived rating of effectiveness of behaviors (aOR: 4.3, 95% CI: 2.8-6.9) and higher levels of perceived ability to adopt social distancing strategies (aOR: 1.8, 95% CI 1.1-3.0). Interpretation: In the last two months, members of the public have been inundated with messages about hygiene and social (physical) distancing. However, our results indicate that a continued focus on supporting community understanding of the rationale for these strategies, as well as instilling community confidence in their ability to adopt or sustain the recommendations is needed.


Tests of thermodynamic properties will be needed before and after over haul of steam turbine units,in order to assess the performance of the equipment and provide directions for operation of electricity plant and maintenance tasks in a power plant.In thermal power plants,the existing data transmission of various thermodynamic parameters adopts wired data,and the construction is complicated.A set of complete wireless data collecting system based on NRF9E5 data-collecting modules for measurements of thermodynamic properties of a steam turbine is put forward in this paper.The system possesses advantages such as multiple test points,easy extension,perfect interfer-ence resistance.


Abstract : An X-ray examination of the development of textures during unidirectional drawing of pure copper at 77K and 196K is reported. Initially, a triplex 100, 111, 112 texture is observed in which the 112 texture forms rapidly and predominates at low strain. This texture is eventually transformed into a dual 100, 111 texture, the rate of transformation being temperature dependent. Calculations of the X-ray absorption across the cross-section of a wire provide an explanation of observed asymmetries of diffractometer traces and pole figures. Such asymmetries are caused by unidirectional drawing conditions, which favour certain slip directions, creating a partial cylindrical texture. (Author)


ABSTRACT An α-Al2O3 bicrystal with a (104)/[110] Σ13 grain boundary was fabricated by joining two pieces of single crystal at 1500°C in an Ar–H2 mixture gas. The resultant grain boundary was characterised by scanning transmission electron microscopy (STEM) at the atomic level. STEM observations revealed that the grain boundary consists of two regions with different atomic structures. These two structures were identified to be the most and second-most stable structures by theoretical calculations and STEM image simulation. The coexistence of two different structures in the Σ13 grain boundary is discussed.


(54) MANGANESE ALLOY SPUTTERING (30) Foreign Application Priority Data TARGET AND METHOD FOR PRODUCING THE SAME Apr. 16, 2001 (JP)...................................... 2001-116323 Jun. 1, 2001 (JP)...................................... 2001-167040 (75) Inventor: Yuichiro Nakamura, Ibaraki (JP) Publication Classification Correspondence Address: HOWSON AND HOWSON (51) Int. Cl. SUTE 210 C23C I4/00 (2006.01) SO1 OFFICE CENTER DRIVE (52) U.S. Cl. ........................................................ 204/298.12 FT WASHINGTON, PA 19034 (US)


We propose an approach to diagnosing brain hemorrhage by using deep learning. In particular, three types of convolutional neural networks that are LeNet, GoogLeNet, and Inception-ResNet are employed. In the training phase, we only train the last fully-connected layers of GoogLeNet and Inception-ResNet, but do train all layers of LeNet. We build a dataset consisting of 100 cases collected from the 115 Hospital, Ho Chi Minh City, Vietnam. The experimental results show that LeNet, GoogLeNet, and Inception-ResNet achieve accuracy of 0.997, 0.982, and 0.992 respectively on the dataset. Through experimental results, we found that convolutional neural networks are pre-trained with non-medical images like GoogLeNet or Inception-ResNet can be used in medical image diagnosis, particularly in brain hemorrhage diagnosis. And, we confirm that among the three deep models, LeNet is the most time-consuming model.


Recent developments in binding systems, new material systems, installation and pre-cast shapes of refractory castables are introduced and discussed. In the author's view, binder systems are advancing towards, on the one hand, purification by minimizing impurity components from binders, and, on the other hand, stabilization by minimizing the destruction of the structures by the volatility and decomposition of binders. The challenges of higher operating temperatures, slag resistance, clean steel production and better thermal shock resistance have promoted a boom in new types of castables including MgO based varieties and natural flake graphite or nonoxide containing systems. Installation techniques are developing towards convenience, simplification and high efficiency. Advancements in installation and dry-out are an incentive to boost self-flow castables, shotcreting castables, infiltration casting, quick dry-out castables and pre-cast shapes. With castables in the form of pre-cast shapes being used to an ever increasing extent, the boundary between shaped and unshaped is becoming vague.


In shrimp aquaculture one feasible way to reduce shrimp production costs and increase producers ́ profitability is the use of feeds with low fish meal levels or alternative protein sources with the aim of an organic certification. The main problem in realising organic shrimp aquaculture is often the lack of suitable protein sources. Our protein source derives from deep-sea shrimp fishery in Costa Rica certified as sustainable. Also important is the trading of the produced organic shrimps. In our case certifier for organic aquaculture of marine shrimp the German certifier "Naturland" guarantees the selling of every organic produced shrimp. Regarding their guidelines fish meal content of the experimental diets is limited to a maximum of 20 % of the total mass. This study was carried out on a marine shrimp farm in Jicaral, Costa Rica and had the goal to test the possibility of using a locally available resource that is currently being wasted. A 48-day feeding trial was carried out to compare two test diets to one commercial control diet (Nicovita 35 % protein). The two experimental feeds were prepared with fish meal of Physiculus talarae, Pontinus cf sierra and Hippoglossina bollmani, three common species that form part of the normal by-catch of the deepwater shrimp fishery in Costa Rica as well as shrimp head meal from Heterocarpus vicarius, integral wheat meal, sunflower oil and a vitamin and mineral premix. Pacific white shrimp, Litopenaeus vannamei, were used to test both diets in comparison to the above mentioned commercial feed. Test diets were fed to shrimp with an initial weight of 10.8 g ± 0.56 to evaluate their growth and feed utilisation parameters: size and weight gain, feed consumption, Feed Conversion Ratio (FCR), survival, Protein Efficiency Ratio (PER), Body Weight Gain (BWG) and Specific Growth Rate (SGR). At the end of the experiment, average weight was 16.7 g ± 0.7 in the control diet, 16.6 g ± 1.6 and 16.7 g± 0.4 in the two experimental diets, suggesting that by-products and processing wastes from marine shrimp fisheries can efficiently be used in feeds for Litopenaeus vannamei.


Considering the wide range of variability of all aerosol characteristics (especially in the near-ground layer of the atmosphere near industrial centers), when creating a realistic empirical model of optical and microphysical characteristics, the optimal dividing of the total data array according to some multifactor signs is needed. In this paper, we analyze the main states of "dry" aerosol on the basis of the results of long-term regular measurements in the near-ground layer of the atmosphere near the city of Tomsk in 2000–2017. The following parameters were considered: aerosol number concentration and size distribution function, total and angular scattering coefficients, including the small-angle range 1.2° to 20°, mass concentration and size distribution of absorbing substances (equivalent black carbon), characteristics of the aerosol hygroscopic properties, and spectral aerosol extinction of radiation on an open long path in the wavelength range 0.45 to 3.9 µm. In our comprehensive study, we first proposed and developed an original approach (classification) to study the optical and microphysical properties of atmospheric aerosol of various physicochemical origins (background, smoke, smog, anthropogenic, etc.) based on dividing the entire data array into characteristic subarrays (types of aerosol weather), which differ from each other in a different combination of scattering and absorbing properties of particles. To divide the total data array into types of aerosol weather including "Background", "Haze-S", "Smog", and "Smoke haze", the values of the scattering coefficient of the dry aerosol matter σd(λ = 0.51 μm) = 100 Mm−1 and the ratio of the mass concentration of the absorbing substance to the mass concentration of submicron aerosol P = 0.05. The results showed that most of the seasonal average values of the aerosol parameters analyzed in the paper are statistically significantly different when comparing various characteristic types of scattering and absorbing atmospheric aerosol. The results of the research indicate that the application of the developed classification of types of aerosol weather for the analyzed optical and microphysical parameters of aerosol particles is quite effective and reasonable.


Abstract : The long term goal of this project is to determine optimal sampling strategies for drifting buoys, in order to enhance prediction of particle motion in the ocean, with potential applications to ecological, search and rescue, floating mine problems, design of observing systems and development of navigation algorithms.


EPIDEMIOLOGY
For the first time, a study of HIV-infected pregnant women has found that coinfection with malaria significantly increased a mother's risk of transmitting the AIDS virus to her baby before or during birth.

According to a report in the November issue of the journal AIDS , HIV-infected pregnant women in the Rakai district of Uganda had nearly three times the risk of transmitting the AIDS virus to their babies if they concurrently had malaria and if the parasite that causes the disease had infected their placentas. "I was startled by the findings," says the paper's first author, epidemiologist Heena Brahmbhatt of Johns Hopkins Bloomberg School of Public Health in Baltimore, Maryland.

In January 2002, Brahmbhatt, then a Ph.D. candidate at Hopkins studying mother-to-child transmission (MTCT) of HIV, read a report that an antimalarial drug might reduce HIV transmission to infants through their infected mother's breast milk. Intrigued by the possible impact of the drug, Brahmbhatt asked her adviser, Hopkins epidemiologist Ronald Gray, if she could look for the effect of malaria in data from Gray's well-known Rakai study. The study, conducted in collaboration with several Ugandan research groups, evaluated MTCT in 746 HIV-infected pregnant women and their babies in Uganda's Rakai district from 1994 to 1999.

Brahmbhatt found 93 cases in which the researchers had ascertained the baby's HIV status and also had preserved the placenta. Of the 15 babies whose mothers had placental malaria, she found that six (40%) became infected. In contrast, HIV spread to only 12 of 78 infants (15%) whose mothers did not have malaria in their placentas. Brahmbhatt emphasizes that the sample size is small, and the findings are not conclusive. Still, the results were statistically significant, leading the authors to conclude that trials are "urgently needed" to evaluate whether giving HIV-infected pregnant women malaria prophylaxis can also reduce the transmission of HIV. "If our observations pan out, there may be a case for much more aggressive malaria suppression in HIV-infected women during pregnancy," says Gray.

![Figure][1]

Net gain.
Protecting pregnant women from malaria may help thwart the spread of HIV from mother to child.

CREDIT: ORC MACRO/CSTS+PROJECT

Few studies have been done on the relationship of placental malaria and the maternal transmission of HIV. In 1998 a preliminary report on HIV-infected women in Kisumu, Kenya, hinted at a similar effect. But a lead investigator in that work, Richard Steketee of the U.S. Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia, says a more thorough analysis showed that, overall, placental malaria did not increase a woman's risk of transmitting HIV to her baby. "The [Rakai and Kisumu] studies don't match up, but that doesn't mean either one is wrong, because the methodology is different," says Steketee, who heads CDC's malaria epidemiology branch.

Steketee's results, in press at Emerging Infectious Diseases , offer a clue to the complex interaction of the two diseases in a pregnant woman. In Kisumu, the researchers assessed the parasitic burden in the placentas. Curiously, they found some protection from HIV when a placenta had a low level of parasites, but the risk of MTCT increased when the parasite density rose to high levels. Hopkins's Gray says he and his co-workers now plan to conduct a similar analysis in the placentas they collected.

Steketee suspects that the intensity of the malaria infection modifies the mother's immunity in different ways, affecting HIV's ability to transmit in utero. "It would be important for someone to look at this again," says Steketee. "These are not easy studies and they are not cheap, but the impact could be substantial."

 [1]: pending:yes


Today, current problems and pneumonia, gastric ulcers, which can be regarded as an independent disease or as a complication. In this paper we describe the contents of cytokines (CC) in the blood during the early period of experimental pneumonia disease and stomach ulcers. For the experiment, we selected two models of disease: experimental pneumonia (EP) and peptic ulcer (PU). Materials and methods. The study was conducted on 39 male guinea pigs, weighing 180 210 g test animals were divided into three groups. The experimental pneumonia caused by the method Shlyapnykova V. N., Solodova T. L., gastric ulcer simulated method Komarov V. I. All guinea pigs carried determine the concentration of cytokines: TNF-α, IL-6 and IL-10 in serum using ELISA (ELISA) using the kits of the company «Diaclone» (France), according to the enclosed instructions. Digital statistical results processed by using Student's criterion. Results and discussion. In the study of the system EP and cytokines in VHSH found that in the test day of the experiment were as likely changes in the content of proinflammatory and antiinflammatory cytokines compared with the group of intact animals Results and discussion, CC proinflammatory IL-6 was found to increase its concentration to 61.1% (r≤0,05) on the fourth day, the eighth day of the disease models, this figure increased by 68.9% (r≤ 0.05) compared with kotrolem. A similar trend was observed from the following cytokines TNF-α, which is typical of proinflammatory


Recently resistive switching (RS) based on ZnO thin film has attracted considerable attention since ZnO with doping can improve the switching ratio and device performance. In this work, Cu/ZnO/AZO (Al-doped ZnO) and Cu/ZnO:Cu (Cudoped ZnO) /AZO structures were fabricated for RS, using AZO as bottom electrodes due to its lattice matching with ZnO, and metal Cu was deposited as the top electrodes. The current-voltage (I-V) characteristics of these RS devices using different doped ZnO thin films as a dielectric layer were analyzed and compared. The results demonstrated that ZnO:Cu RS had a higher switching ratio and a larger range of setup and reset voltage than ZnO RS. In addition, we also found that the high resistance state(HRS)and the low resistance state (LRS) were accordance with space charge limited current (SCLC) and Ohm's law respectively. In addition, the effect on RS performance by the top electrode was investigated by depositing top electrode with different sizes and annealing treatment, and the results indicate that the RS phenomenon occurred in these Cu/ZnO:Cu/AZO structure devices is caused by bulk effect and interfacial effect synthetically.


Objective To observe the effect of Curcumin on the vascular permeability in rat models of ovarian hyperstimulation syndrome(OHSS).Methods Twenty-seven SD rats were randomized into the normal group,model group and Curcumin group,with 9 in each.The OHSS models were established with subcutaneous injection of pregnant mare serum gonadotropin(PMSG) and human chorionic gonadotropin(HCG) in the model group and Curcumin group.The Curcumin group was given 50 mg/(kg·d) of Curcumin suspension intragastrically.The normal group and model group was given the same amount of 0.5% sodium carboxymethyl cellulose solution intragastrically.The intragastric administration lasted for one week in the three groups.The morphology characteristics and differences of ovarian tissue were observed by optical microscope.The ovarian weight,peritoneal washings Evans blue(EB) content and serum estradiol(E2) level was recorded.The expression of vascular endothelial growth factor(VEGF) and VEGF receptor(VEGFR) in the ovarian tissue was detected.Results The volume of intraperitoneal recovery fluid,ovarian weight,EB content and E2 level in the model group was significantly higher than those in the normal group(P0.05).The volume of intraperitoneal recovery fluid,ovarian weight,EB content and E2 level in the Curcumin group was significantly lower than those in the model group(P0.05).The levels of VEGF and VEGFR in the model group were significantly higher than those in the normal group(P0.05).The levels of VEGF and VEGFR-2 in the Curcumin group were significantly lower than those in the model group(P0.05).Conclusion Curcumin could reduce the vascular permeability of OHSS by reducing the levels of VEGF and VEGF-2.


Introduction: The different characteristics of the elderly and young people may provide different characteristics of COVID-19. This research aim is to provide information on the characteristics of COVID-19 patients, especially elderly patients. Aim: To analyzed comparisson of clinical characteristic COVID-19 in elderly and young age patients. Method: This study is a retrospective observational study with a cross-sectional approach in COVID-19 patients hospitalized at Soewandi General Hospital from May 1st 2020 until November 31th 2020. This study compared the characteristics of COVID-19 patients at elderly and young ages. Result: There were 368 COVID-19 patients with 95 elderly patients (25.81%) and 273 young patients (74.19%). The most frequent symptoms experienced by elderly patients in sequence are cough, gastrointestinal disturbances, fever, and fatigue. It was found that the proportion of COVID-19 patients with comorbid diabetes mellitus (DM) and hypertension (HT) was higher in elderly patients than in younger patients (p <0.05). There were statistically significant
differences in the values of hemoglobin (Hb), lymphocytes, hematocrit, mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), SGPT, blood urea nitrogen (BUN), serum creatinine (Sc), and D-Dimer between the elderly and young age groups (p <0.05). Conclusion: COVID-19 has different clinical and laboratory characteristics between the elderly and young population. In the elderly infected with COVID-19 population, we need more comprehensive clinical and laboratory evaluation to prevent COVID-19 morbidity and mortality. Keryword: COVID-19, elderly patients, hematologic parameter


The structure of (Et4N)4KAuAs4Te8 consists of two different cations and an AuAs4Te85- anion. The AuAs4Te85- anion can be considered in terms of two As2Te44- anions coordinating to a Au3+ cation to form a square-planar AuTe4 unit. However, molecular orbital calculations show that the Au cations of the square-planar AuTe4 units in (Et4N)4KAuAs4Te8 and other compounds are best described to be monovalent Au+. Electron-counting problems for the square-planar AuTe4 unit and its isostructural analogue TeTe4 unit are discussed.


Abstract This paper is concerned with global stability of strong rarefaction waves of the Jin–Xin relaxation model for the p-system. The proofs are given by an elementary energy method and the existence of a positively invariant region obtained by Serre [Serre, D. (2000). Relaxations semi-lineaire et cinetique des systemes de Lois de conservation. Ann. Inst. H. Poincare Anal. Non Lineaire 17(2):169–192] plays an important role in our analysis.


In their paper published in 1952, Hestenes and Stiefel considered the conjugate gradient (CG) method an iterative method which terminates in at most n steps if no rounding errors are encountered [24, p. 410]. They also proved identities for the A-norm and the Euclidean norm of the error which could justify the stopping criteria [24, Theorems 6:1 and 6:3, p. 416]. The idea of estimating errors in iterative methods, and in the CG method in particular, was independently (of these results) promoted by Golub; the problem was linked to Gauss quadrature and to its modifications [7], [8]. A comprehensive summary of this approach was given in [15], [16]. During the last decade several papers developed error bounds algebraically without using Gauss quadrature. However, we have not found any reference to the corresponding results in [24]. All the existing bounds assume exact arithmetic. Still they seem to be in a striking agreement with finite precision numerical experiments, though in finite precision computations they estimate quantities which can be orders of magnitude different from their exact precision counterparts! For the lower bounds obtained from Gauss quadrature formulas this nontrivial phenomenon was explained, with some limitations, in [17]. In our paper we show that the lower bound for the A-norm of the error based on Gauss quadrature ([15], [17], [16]) is mathematically equivalent to the original formula of Hestenes and Stiefel [24]. We will compare existing bounds and we will demonstrate necessity of a proper rounding error analysis: we present an example of the well-known bound which can fail in finite precision arithmetic. We will analyse the simplest bound based on [24, Theorem 6:1], and prove that it is numerically stable. Though we concentrate mostly on the lower bound for the A-norm of the error, we describe also an estimate for the Euclidean norm of the error based on [24, Theorem 6:3]. Our results are illustrated by numerical experiments.


The goal of the research is to get knowledge of heritage implementation of
ethnic Pamona in North Pamona sub district. The other research of the goal is also
to get information on how the heritage system of ethnic Pamona in North Pamona
sub district is implemented nowadays.
This is an descriptive analysis research, a research which present a picture
in whole and systematic on the objective based on data that has connection with
heritage system that is implemented by ethnic Pamona in North Pamona sub
district nowadays. This research consists of two subjects: 10 descendents, 15
heirs, and 2 important figure of the tribe. Chief of the village, and head of North
Pamona sub district ini North Pamona sub district. The technique of the sampling
is non-probability sampling, a sample adoption system which give no same
opportunity to every factor of the population number which is adopted as sample.
The method of the research is by logical inductive approach


Conventional banks, which operate under the conditions of interest capitalism, no longer dominate the financial sector. In the 21st century, Islamic banks, which provide services on an interest-free basis, have become their main competitors. In recent years, Islamic banking has grown rapidly even though 30–40 years ago it was only a regional phenomenon that could be found in countries with a predominantly Muslim population. The dispersal of capital by scaling a separate interest-free banking segment is now on the agenda of the Islamic world. It is stimulating the growing social demand for a fair distribution of resources within the community, as well as sustaining, at the same time, resilient economic development. However, the activity of Islamic banks remains a poorly studied and understood phenomenon within the circles of Russian legal science. In this article, the authors reveal the legal nature of the participation transaction involving shirkat al'-inan, while attempting to clarify the notion of using musharakah as a form of civil law, derived from shirkat al'-inan, within the Islamic banking system.


Three long-time concrete test programs were started at the University of Wisconsin-Madison in 1910 (Series B) and 1937 (Series C). Previous reports were published in the ACI Journal in 1931, 1943, 1961, and 1975. The 1937 program required 480 cylinders of 4 x 6 x 24 in. Compressive strength, unit weight, and volume changes up to 50 years are given. In addition, transverse strength and static and dynamic moduli of elasticity at 50 years are given. Variables included cement type, mix proportions, consistency, and methods of placement. All speciimens made in 1937 were cured outdoors after a 28-day moist-curing period. Generally, compressive strength at 50 years showed little change from the strength at 10 years.


B‐cell chronic lymphocytic leukaemia (B‐CLL) and B‐cell precursor acute lymphoblastic leukaemia (B‐ALL) are the most common type of leukaemia in adults and children, respectively. Today, fluorescence in situ hybridization (FISH) is the standard for detecting chromosomal aberrations that reflect adverse and favorable outcome. This study revealed a new, simple, and fast diagnostic tool to detect pathological cells by measuring and imaging the fluorescence lifetime (FLT) using FLT imaging microscopy (FLIM) of the peripheral blood (PB) cells of B‐CLL samples that were labeled with the DNA binder, DAPI. The FLT of DAPI in healthy individuals was found to be 2.66 ± 0.12 ns. In contrast, PB cells of B‐CLL and BM cells of B‐ALL patients were characterized by a specific group distribution of the FLT values. The FLT of DAPI was divided into four subgroups, relative to 2.66 ns: short+, normal, prolonged, and prolonged+. These alterations could be related to different chromatin arrangements of B‐CLL and B‐ALL interphase nuclei. Notably, extremely long FLT of nuclear DAPI correlate with the presence of extra chromosome 12, while moderate increases compared to normal characterize the deletion of p53. Such correlations potentially enable a FLT‐based rapid automatic diagnosis and classification of B‐CLL even when the frequency of genetic and chromosomal abnormalities is low. © 2016 International Society for Advancement of Cytometry


Chloroquine phosphate, primarily an antimalarial and amebacidal drug, has been used with considerable success in the treatment of chronic discoid lupus erythematosus1and in actinic dermatitis.2Because of its efficacy in these dermatoses, it was almost inevitable that it would be used in other dermatoses on an empirical basis. We first became interested in trying it in other dermatoses after using it with considerable benefit in a case of lichen planus. This, of course, led us to try it first in other cases of lichen planus as they became available and subsequently in a variety of unrelated dermatoses that had been treatment problems. METHOD AND RESULTS Chloroquine (Aralen) phosphate (tablets 250 mg., containing 150 mg. of chloroquine base) was prescribed to be taken orally, usually twice daily for one week, then once daily. In a few cases, the twice daily dose was continued beyond one week or was


We present an algorithm that produces new families of closed simply connected spin symplectic\/ $4$-manifolds with nonnegative signature that are interesting with respect to the symplectic geography problem. In particular, for each odd integer $q$\/ satisfying $q\geq 275$, we construct infinitely many pairwise nondiffeomorphic irreducible smooth structures on the topological\/ $4$-manifold $q(S^2\times S^2)$, the connected sum of $q$\/ copies of $S^2\times S^2$.


The current project "Business Plan for the creation of a motel in the Tapalan neighborhood Culahuango route in Latacunga city in the year 2014", has as aim to demonstrate the feasibility of creating through the systematic development of a business plan that offers a new alternative of tourist accommodation for that sector, ,because the currently problem is the lack of tourist accommodation that can contribute to the development of the economy and tourism in order to improve the economy of that population and economic conditions of employees and investors.
For that the best option that has been determined to give a possible solution to the problem raised in that place, according to its location, economic conditions, culture, customs of the people is building a motel for those people who are seeking a short stay or visit the sector.
With regard to research and study of the thesis theme is disclosed that by collecting methodical data used as techniques of observation and surveys of the population, was determined and verified the feasibility of their implementation, also important data such as the amount of unsatisfied demand was obtained in which a percentage of 74% of persons or potential customers to, who the service may be offered according to the installed capacity of the project which are going to be implemented in the agreed year, was determined.


DIAGNOSIS. Balionycteris maculata (Fig. 1) can be readily distinguished from other small species of Pteropodidae by a single pair of lower incisors, 2 pairs of upper molars, and by characteristic pale spots on wing membranes, particularly on joints of digits (Lekagul and McNeely 1977; Medway 1983; Payne et al. 1985). Among similar species and genera, Chironax melanocephalus and Cynopterus have 2 pairs of lower incisors, 1 pair of upper molars, and plain wing membranes, with no pale spots; Aethalops alecto has 1 pair of upper molars, a thickly furred interfemoral membrane, and no wing markings (Lekagul and McNeely 1977; Medway 1983; Payne et al. 1985).


Objective:To investigate the mechanism of Baduanjin in the treatment of type 2 diabetes mellitus. Methods:The literature research was conducted to analyze the mechanism of Baduanjin from the etiology of diabetes. Results:It was initially proved the mechanism of Baduanjin in the etiology of diabetes from the perspective of traditional Chinese medicine and Western medicine. Conclusion:The principle of Baduanjin of traditional Chinese medicine and Western medicine treatment of diabetes and it's important in the treatment of diabetes.


Anaesthesiology is one of the youngest branches of medical science that has made immense development. During last 30 years, role of anaesthesiologist has extended not only inside but also outside traditional operating room settings. Anaesthesiologist plays a very critical role in intensive critical care units, trauma centres, and pain clinics and as a member of resuscitation team all over the world.1 Since last decade there is tremendous health care awareness, mainly in developed countries. In India also people have begun having awareness since CPA (consumer protection Act 1986) has come into existence. But still they have hardly any knowledge of the structure of medical services and practices specially relating to operating room services and anaesthetic management2. The knowledge of the role of anaesthesiologist and the Anaesthesia speciality among the public is limited.2


A (111)Pt/(001)cLaNiO3/(001)(100)Pb(Zr0.44Ti0.56)O3/(001)cLaNiO3/(111)Pt/TiO2/SiO2/(001)Si heterostructured piezoelectric microcantilever demonstrated a high fatigue endurance over 1×1010 switching cycles and a large transverse piezoelectric constant (d31) of about -140 pm/V. The fatigue endurance was improved by suppressing the increase in the number of oxygen vacancies in Pb(Zr0.44Ti0.56)O3 film using LaNiO3 oxide layers as top and bottom electrodes. The origin of the large d31 was a reversible 90°-domain rotation from a- to c-domains, which was confirmed by an in situ two-dimensional X-ray diffraction (XRD2) technique with a 100 µmφ incidence X-ray and a highly sensitive two-dimensional detector under an applied voltage. The XRD2 technique demonstrated the feasibility of superior piezoelectric devices with a large piezoelectric displacement and a high reliability for repetitive operation.


This present work, includes the preparation of rubber batches containing silicone rubber (SIR) (80pphr) and polyurethane (PU) (20pphr) with micro-lead powder in different loading, respectively (0,20.40,60,80,100,150,200,250,300pphr). The mechanical properties measured the device universal tensometer, such as tensile strength, elongation and modulus of elasticity, according standard specified of (ASTM D-412) were followed and the hardness property measured by (Hardness Shore A) was put through its steps according to the standard specification (ASTMD-1415). The results were selected, and the sample (10) consisting of (SIR 80/PU20 and micro-lead 300pphr) was chosen because it is more suitable for the required mechanical properties. The results observed that the ratios of micro-lead loading increased, the tensile and elongation decreased, and the hardness and elastic modulus increased. Rubber batches reinforced with micro-lead were exposed to an infrared (FTIR) test device with the addition of hexane, where there were no changes in the infrared spectrum of the rubber composites (SIR80/PU20/Micro-Pb). Sample No. (10) was shown that the scanning electron microscope (SEM) before and after adding hexane, where it was noted that the image (A) without hexane, the absence of homogeneity of lead. As for image (B) in the presence of hexane, we note the homogeneity of lead and the distribution of lead equally, so that radiation examination were measured the Geiger counter of two sources of radioactive elements were used, the caesium source Cs137 and the cobalt source Co60. The radiation is attenuated through the material, while the thickness of the half (X1/2) gradually contrasts according to the attenuation of the radiation. This work is applied in the applications of shields as a protective suit against harmful radiation.


"In this paper we consider a class of quasilinear wave equations $$u_{tt}-\Delta_{\alpha} u-\omega_1\Delta u_t-\omega_2\Delta_{\beta}u_t+\mu\vert u_t\vert^{m-2}u_t=\vert u\vert^{p-2}u,$$ associated with initial and Dirichlet boundary conditions. Under certain conditions on $\alpha,\beta,m,p$, we show that any solution with positive initial energy, blows up in finite time. Furthermore, a lower bound for the blow-up time will be given."


Objective To evaluate and analyze risk factors of coronary calcification in maintenance hemodialysis patients.Methods 40 maintenance hemodialysis patients with coronary artery CT examination from Jan 2003 to Jan 2010 were divided into coronary calcification group (N =26)and non-coronary calcification group(N = 14).Serum chemical substance and risk factors were compared between two groups.Results The calcium,phosphate,parathyroid hormone,C reactive protein,LDL and CHOL increased in coronary calcification group(P < 0.05).Conclusion Hyperparathyroidism might be a major reason for coronary calcification in maintenance hemodialysis patients.Hemodialysis duration,age,smoking history,diabetes,and obesity are risk factors,and low-calcium dialysate attenuated coronary calcification.

Key words:
Maintenance Hemodialysis; Vascular Calcification; Coronary artery


In a world which is beset with suffering and trauma, in which we encounter in the course of our lives many tramatized women, children, and men, in which many of us have also been abused and have had to deal ourselves with the after effects of trauma, it is imperative that we know something about the nature of trauma and familiarize ourselves with the helpful insights of neuroscience.


In earlier studies at different test rigs, it was experimentally obtained that a combined liner reduces the fan noise level by 2–3 dB more than a two-layer honeycomb treatment of the same length. At present work, in conditions of the wind channel, which modelling the bypass of turbofan engine, it was performed the study of the influence of lattice main design parameters of combined liner such as spacing and slope angle on its acoustic efficiency.


: This article uses Stata16.0 statistical software tools and WPS2016 office software to analyse the data from RESSET financial research database. Select real estate development industry in 2015-2019 a-share listed companies annual reports and related data in nearly five years of financial statements, sum up the relationship between operating liability ratio, short-term loan ratio and long-term loan ratio and business performance of the real estate development industry. A theoretical basis and reference suggestions for real estate development industry in terms of financing decision to be provided.


Ingestion of grapefruit juice has been shown to increase the oral bioavailability of several dihydropyridines and cyclosporine A [1, 2], with the suggested mechanism being inhibition of presystemic metabolism by CYP3A4 [2-5]. The clinical significance of these interactions is uncertain because of a lack of chronic dosing studies [2] and a paucity of pharmacodynamic data [2, 5]. One study has reported increased trough concentrations of cyclosporine in patients dosed chronically with grapefruit juice [5]. We confirm this finding. Ten medically stable renal transplant out-patients (five males, five females, mean age 51 and 45 years, respectively) receiving continuous cyclosporine therapy (mean dose 3.6 mg kg-' day-, range 2.34 to 6.25) were recruited after giving informed consent and approval of the study by the institutional ethics committee. Transplants had been performed between 1.5 and 11.8 years prior to the study. Only one patient received a concomitant low constant dosage of a drug (verapamil) known to effect CYP3A4. A crossover design with 7 days between arms was used, and patients were randomized to receive either 175 ml of 'Hitchcock'® grapefruit juice from a single commercial batch or the same volume of mineral water with twice daily cyclosporine capsules (Sandimmum®) for a period of 7 days each. On day 6 of each arm, patients fasted overnight beginning at 22.00 h. The next morning, cyclosporine was taken 12 h after the previous evening's dose, followed by ingestion of grapefruit juice or mineral water. A small breakfast was served 1 h and a full meal 5 h after dosage. Patients were requested to drink 200 ml mineral water hourly. The second dose of cyclosporine was taken 12 h after the first. Blood samples were collected into plastic EDTA tubes (Monovette®, Sarstedt, Numbrecht, Germany) immediately before dosage and at 1, 2, 3, 4, 5, 6, 7, 9 and 12 h thereafter, and deep frozen at -35° C. Whole blood cyclosporine and metabolite concentrations were assayed using TDx® cyclosporine monoclonal and TDx® cyclosporine and metabolite kits (Abbott Laboratories, Abbott Park, IL 60064). Between-run coefficients of variation were 4.6% at 151.5 gg 1-1 and 3.7% at 864.6 kg 1-1 (monoclonal) and 7.8% at 350.7 kg 1-1 and 4.5% at 1650.1 kg 1-l (nonspecific assay). Corresponding within-run values were 3.0%/1.7% and 3.4%/2.8%, respectively. The working analytical ranges were 25-1500 jg 1-1 and 60-2000 kg 1-1. Values of Cmni, Gmax (kg l ), and tmax (h) were noted directly from the day 7 data. AUC values (kg 1-l h) for the dosing interval (AUC(r)) were calculated using the linear trapezoidal rule. Total metabolites were estimated by subtracting the values obtained with the monoclonal assay from those of the nonspecific assay. Ingestion of grapefruit juice was associated with a significant increase in mean Cmin (136 + 21 s.d. vs 241 + 84 s.d.; 95% CI of difference, 43 to 166) and AUC(r) (3241 ± 481 vs 4329 ± 1272; 95% CI of difference, 187 to 1989) values of unchanged cyclosporine, but no significant change in Cmax (655 ± 137 vs 718 ± 311; 95% CI of difference, -181 to 308). Median values of tmax were 2 (range: 1-3) and 3 (range: 1-8). Total metabolites showed a corresponding significant increase in mean Cmin (191 ± 48 vs 310 ± 160; 95% CI of difference, 32 to 205) and of AUC(t) (2899 + 805 vs 4493 ± 2167; 95% CI of difference, 391 to 2798) without significant change in Cmax (431 ± 146 vs 522 ± 261; 95% CI of difference, -92 to 276). Median values of tmax were 2 (range: 1-3) and 4 (range 2-7). The mean metabolite/cyclosporine AUC(r) ratios were 0.887 ± 0.168 vs 1.027 ± 0.352 with a 95% CI of difference of -0.038 to 0.318. Thus, the results indicate a mean increase of 77% and 62% in the trough concentrations of cyclosporine and its metabolites, respectively, and a 34% and 55% increase in the AUC(t) during continuous ingestion of grapefruit juice, confirming previous findings [5]. It has been suggested that such changes are caused by inhibition of the pre-hepatic CYP3A4-mediated metabolism of cyclosporine in the gut wall [2, 5]. However, we did not demonstrate a lower metabolite/cyclosporine ratio in blood.


A 22-yr-old woman was scheduled for split-thickness skin grafting of the stump and revision of the stump under epidural anesthesia 1 mo after a traumatic amputation of the right leg just below the knee. A similar procedure had been performed uneventfully 2 wk previously. Intravenous hydration with a Ringer's lactate solution was started after the blood pressure was measured using a sphygmomanometer. The electrocardiogram was continuously monitored. With the patient lying on the left side and after the epidural space was identified using the loss-ofresistance technique with liquid, a catheter (Perifix G18, Braun, Helsungen, Germany) was inserted at the L3-4 interspace for a distance of 3 cm without encountering any significant resistance. There were no paresthesias. Two milliliters of 2% mepivacaine


The primary purpose of the paper is to identify non-price incentives provided by farming contracts. They aim at motivating agents to conduct their actions according to contractors' interests. Therefore their application of these inducements might minimise the issue of moral hazard during its validity, i.e. as the production progresses. The author carried out her empirical research based on the survey among producers' groups operating in the poultry market, while the particular emphasis was placed on farming contracts signed in 2014. The obtained results allow for identification of non-price incentives which are supposed to help monitor and tackle the problem of moral hazard with hidden action on the side of agents/ groups of poultry producers. As a conclusion, five types of incentives were determined.


Book Citations: Authors, Title, HemaSphere, 2023;7(S3):pages. The individual abstract DOIs can be found at https://journals.lww.com/hemasphere/pages/default.aspx. Disclaimer: Articles published in the journal HemaSphere exclusively reflect the opinions of the authors. The authors are responsible for all content in their abstracts including accuracy of the facts, statements, citing resources, etc. 428 Exogenous IL-1β induced STAT2 phosphorylation in control MKs. JAK blockade by pyridone 6 suppressed STAT2 phosphorylation and reduced NEU1 expression. After IL-1β treatment, IFN-β was detected in the cell supernatants, indicating IFN-β secretion by stimulated MKs. In vitro baricitinib treatment of ITP-MKs inhibited STAT2 phosphorylation, reduced the surface expression of NEU1, and alleviated surface desialylation. In vivo administration of baricitinib completely rescued the induced thrombocytopenia in ITP murine model (no significant differences compared with healthy controls). BM immunofluorescence verified the abnormal MK distribution and upregulated NEU1, IL-1R1, and IFN-β expression in ITP murine model, which were also alleviated by baricitinib treatment. Summary/Conclusion: IL-1β signalling may induce JAK/STAT activation to promote NEU1-mediated desialylation in ITP-MKs, leading to impaired platelet production. Baricitinib has the potential to alleviate NEU1-mediated desialylation and improve thrombopoiesis. HemaSphere | 2023;7(S3) EHA2023 Hybrid Congress Copyright Information: (Online) ISSN: 2572-9241 © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association. This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) which allows third parties to download the articles and share them with others as long as they credit the author and the Abstract Book, but they cannot change the content in any way or use them commercially. Abstract Book Citations: Authors, Title, HemaSphere, 2023;7(S3):pages. The individual abstract DOIs can be found at https://journals.lww.com/hemasphere/pages/default.aspx.Book Citations: Authors, Title, HemaSphere, 2023;7(S3):pages. The individual abstract DOIs can be found at https://journals.lww.com/hemasphere/pages/default.aspx. Disclaimer: Articles published in the journal HemaSphere exclusively reflect the opinions of the authors. The authors are responsible for all content in their abstracts including accuracy of the facts, statements, citing resources, etc. 429


To understand the effect of physical activity on the depression status of Chinese students studying in Russia.The authors used the SDS depression self-assessment scale and physical exercise assessment scale to survey350 Chinese students in some Russian universities, and collected the questionnaires on their mobile phones.The basic situation was investigated and the data was analyzed statistically. Use SPSS to assess the correlationbetween physical activity and depression. It was found that appropriately increasing the amount of physicalactivity can effectively improve depression and be beneficial to the development of mental health of Chinesestudents studying in Russia.


1Adaptive filtering is a wide area of researcher in present decade in the field of communication. The LMS algorithm is the most popular method for adapting a filter. The Least Mean Square adaptive filter is used here to reduce area-delay product, power-delay product and this paper also deals with cancellation of noise on speech signal using Least Mean Square (LMS) algorithm. As received signal is continuously corrupted by noise where both received signal and noise signal both changes continuously, then this arise the need of adaptive filtering.


Abstract Thirty-eight kindergartners were individually interviewed with reading and writing tasks in September, November, January, March, and May. Half of the children received phonics instruction, in isolation, from a teacher who identified herself as a phonics teacher. The other half received phonics instruction, in context, from a teacher who identified herself as a whole language teacher. It was found that the whole language group made more progress in both reading and writing, and with more developmental coherence, as evidenced by the absence of regression and confusion. The results were interpreted in light of the theories of Ferreiro (Ferreiro, 1978; Ferreiro & Teberosky, 1979/1982) and Piaget (1926/1967; Piaget & Inhelder, 1968/1973).


This study explores the practice of alternative medicine among a group of senior, transnational Indian immigrants. I analyze how cross-cultural ideologies influence aging and immigrant experiences in healthcare. I explore the ways in which transnational networks nurture social relations and aid in acquiring healthcare resources. This study also examines the developments that alternative medicine underwent during the colonial rule and how those developments affected the trajectory of biomedicine. I focus on the practice of alternative medicine as a significant contributor to immigrant health. Finally, I argue that we need to strive for a symbiosis between alternative medicine and Western biomedicine based on multicultural sensibilities and socio-economic factors that call for a pluralistic medical system in a globalized


This paper describes an application of the hierarchical mixture of experts algorithm (HME) to the registration of multiple cartographic models to noisy radar data. According to the HME algorithm each model is represented by a set of maximum likelihood registration parameters together with a set of matching probabilities. This architecture can be viewed as providing simultaneous registration and hypothesis verification. The maps in the cartographic data-base compete to account for radar data through the imposed probability normalisation. The resulting matching algorithm can be regarded as a generic tool for model retrieval from a database. Our evaluation on radar images illustrates some of the characteristics of the algorithm. Our main conclusions are that the method is both robust to added image noise and poor initialisation.


Do accruals-based accounting earnings provide better information to investors about future operating cash flows than operating cash flows themselves, as predicted by FASB's conceptual framework? The most recent evidence (Nallareddy et al., 2020) is that operating cash flows, measured correctly using cash flow statement data, consistently outperform earnings. However this evidence compares operating cash flows with "bottom line" earnings, handicapping earnings by including non-operating and transitory components with no corresponding operating cash flow. Operating earnings consistently dominate operating cash flow's predictive ability in a battery of tests, especially after addressing cross-sectional differences among firms.


Abstract This phenomenological study sought to identify the attributes of meaningful learning experiences as found in an outdoor education program. Thirteen students in the Wilderness Writing Program at Brigham Young University were the sample of this study. Their participation in outdoor recreational activities and their reflections about their experiences were analyzed. Through written journal entries, group discussions, observations, and writing assignments, a qualitative analysis identified attributes that occurred in their meaningful learning experiences. Meaningful learning was defined as a realization of a person's weaknesses, strengths, and potentials. This realization came through experiences with attributes of a degree of perceived risk, which led to a feeling of awkwardness, followed by a purifying process, or sublimation. A reflective period allowed for reconstruction of a person's view of himself or herself and this was closely tied with feedback from others in the group.


Suitable analytical methods must be tested and developed for monitoring the individual process steps within the fuel cycle of a fusion reactor and for tritium accountability. The utility of laser-Raman spectroscopy accompanied by mass spectrometry with an Omegatron was investigated using the analysis of all hydrogen isotopes and isotopically labeled methanes as an example. The Omegatron is useful for analyzing all hydrogen isotopes mixed with the stable helium isotopes. The application of this mass spectrometer were demonstrated by analyzing mixtures of deuterated methanes. In addition, it was employed to study the radiochemical Witzbach exchange reaction between tritium and methanes. A laser-Raman spectrometer was designed for analysis of tritium-containing gases and was built from individual components. A tritium-compatible, metal-sealed Raman cuvette having windows with good optical properties and additional means for measuring the stray light was first used successfully in this work. The Raman spectra of the hydrogen isotopes were acquired in the pure rotation mode and in the rotation-vibration mode and were used for on. The deuterated methanes were measured by Raman spectroscopy, the wavenumbers determined were assigned to the corresponding vibrations, and the wavenumbers for the rotational fine-structure were summarized in tables. The fundamental Vibrations of the deuterated methanes produced Witzbach reactions were detected and assigned. The fundamental vibrations of the molecules were obtained with Raman spectroscopy for the first time in this work. The @-Raman spectrometer assembled is well suited for the analysis of tritium- containing gases and is practical in combination with mass spectrometry using an Omegatron, for studying gases used in fusion.