The authors develop a Monte Carlo position space renormalisation group method to study the scaling properties of bootstrap percolation. In this model sites on a lattice are randomly occupied with probability p and sites with less than m occupied neighbours are culled until a stable configuration remains. Using progressively larger length rescaling factors b, they obtain numerical results on the triangular lattice for the percolation threshold pc(b), the connectedness length exponent nu (b) and the fractal dimension df(b). The large b limit yields numerical values of df for m=2 and 3 which are consistent with df for ordinary percolation (m=0). Although the small b dependence of nu for m=2 and 3 is qualitatively different from that of ordinary percolation, the large b behaviour of nu suggests that m=2 and m=3 bootstrap percolation on the triangular lattice are in the same universality class as ordinary percolation.


XOR-AND Graph (XAG) is a logic representation method for Boolean functions. A major advantage of using XAG is that it is efficient for cryptography and security applications in which the number of AND gates relates to the multiplicative complexity. A Reed-Muller logic expansion is used in this paper to develop an area-aware optimization method for XAG. The logic functions can be represented in several ways by Reed-Muller logic based on different polarities. To find an area-efficient representation of the logic network, the cuts of the logic network are enumerated and then the mixed polarity conversion algorithm is utilized. When the representation is improved over the existing one, we replace the existing cut. Following the experimental results over EPFL benchmark suites, the proposed method can optimize XAG size. Compared with the best known results, we achieve a reduction of up to 50% and an average reduction of 14% in the number of XOR gates.


Oil is the world's biggest and most pervasive business, the greatest of the great industries that arose in the last decades of the nineteenth century.These words of Daniel Yergin in his book, The Prize (1991), which chronicles the development of the world's oil industry, highlight the importance of oil industry in the recent times. In an environment of growing competition, higher resource costs, and significant price uncertainty, 'Investment Decision Making' is given top priority. There are many decision making techniques in academic literature. Some fundamental concepts were formulated more than two hundred years ago. But their application became apparent only in the 1950s and 1960s. Their application in practical decision making has been made recently. It is an acknowledged fact that the current practice techniques used for investment decision making in most industries lag behind the current decision theories.Which techniques are most appropriate and applicable to upstream oil industry is what is to be analyzed here. This study draws on the oil industry literature to find the techniques used by upstream oil companies. It tries to identify the techniques that are available and what are the tools appropriate for upstream investment decision making. Each tool has certain limitations. Thus, a combination of decision analysis techniques and concepts are to be used.The rationale behind this study is the assumption that the techniques used would be adding value to the upstream oil companies. This assumption would then be tested to verify this relationship. The risk and uncertainty involved in each technique is also considered.Investment appraisal, industry literature and the insights gained from various conferences, seminars etc. are used to draw conclusions.


Acute lower gastrointestinal bleeding is defined as a bleeding situation in which blood loss has been occurring for less than 3 days resulting in haemodynamic instability, anaemia, or the need for blood transfusion. Diverticula and angiectasias are the most frequent sources of bleeding. Malignancy, inflammatory bowel disease, non-steroidal anti-inflammatory drugs, infectious colitis, ischaemia, anorectal disorders, postpolypectomy bleeding, and HIV-related problems are less frequent causes. We describe a case of a female patient aged 87 admitted to hospital because of severe intestinal bleeding. The patient was on dual antiplatelet therapy after drug-eluting stent implantation. After red blood cell and fresh frozen plasma infusion, haemostatic drug treatment as well as withdrawal of antiplatelet agents, the patient's condition improved and became stable. Colonoscopy was then performed and residual bleeding from diverticula was revealed. Since the patient was free from symptoms and signs of recurrent bleeding, dual antiplatelet therapy was restarted without further complications.


Ficus deltoidea has traditionally been used to cure several pathological conditions including diabetes. However, none of these claims have been scientifically researched thus far. In this preliminary study, the blood glucose lowering activity of F. deltoidea was monitored through the oral glucose tolerance test. Post-treatment of the aqueous extracts of both the leaves and fruits of F. deltoidea at 50mg/kg dosage significantly reduced the external glucose load. Both extracts were found to be non-toxic as shown by the brine shrimp toxicity test.


Rising threats to American national security in East Asia coincide with declining local support for U.S. basing access there. Yet no alternative access points are currently available. To prevent this contradiction from harming U.S. interests in that strategically vital region, U.S. planners have finally recognized the imperative to build up Guam as a sovereign anchor of America's force posture in East Asia. This article examines regional threats to American interests, Guam's importance as a forward logistics hub, and the infrastructure renaissance and regional access initiatives that will be necessary to help Guam fully realize its new role.


We discuss the reaction of associated production of the top quark pair and Higgs boson at the future International Linear Collider. We assume that the Higgs boson is light and hence, due to its very small decay width, it is produced on mass shell while the top quarks are produced off shell and they decay, each into 3 fermions. This causes a necessity of studying reactions with seven particles in the final state. Concentrating on one semileptonic channel of such reaction, we illustrate the off mass shell effects and calculate the off resonance background contributions. The latter are calculated with the use of a program carlomat for automatic computation of multiparticle cross sections.


Renewed interest in the relationship between trade and income inequality has encouraged the development of new theories. This paper examines whether the predictions of two of these theories along with the much older Stolper-Samuelson theory can be supported by macro data. The results provide no evidence in support of these theories. They instead provide weak evidence that openness decreases income inequality in developed countries while increasing inequality in developing countries. When an instrument is used to correct for possible endogenity, those results disappear. However a Hausman type test shows only an insignificant difference between the OLS and IV results.


Abstract Chimeric antigen receptor T cells have revolutionized the treatment of hematological malignancies during the past five years, boasting impressive response rates and durable remissions for patients who previously had no viable options. In this review, we provide a brief historical overview of their development. We focus on the practical aspects of a patient's journey through this treatment and the unique toxicities and current best practices to manage those. We then discuss the key registration trials that have led to approvals for the treatment of relapsed/refractory acute lymphoblastic leukemia (ALL), diffuse large B cell lymphoma (DLBCL), follicular lymphoma, mantle cell lymphoma (MCL), and multiple myeloma. Finally, we consider the future development and research directions of this cutting edge therapy.


Objective To investigate the multiple pressure-regulation cause and to summarize the clinical experience and strategy of the adjustable shunt valve in bypass post-operation. Methods The causes of the multiple postoperative pressure regulation in 21 cases of the ventriculoperitoneal shunt were analyzed and the basis of clinical and radiographic regulation and the regulating effect were summarized. Results The 21 cases had pressure regulation from 3 to 7 times in vitro; and a satisfactory shunt effect was achieved in all patients. Conclusion The ventriculoperitoneal shunt with the adjustable shunt valve is the direction of the treatment of hydrocephalus. Adjusting the shunt pipe pressure is beneficial to dynamically grasp the change of hydrocephalus and to reduce the postoperative complications. The emphasis on the preoperative pressure setting of the reference factors could significantly reduce the times of postoperative pressure regulation.


The effect of the reaction variables in the Cp 2 TiCl-mediated controlled radical isoprene polymerizations initiated by epoxide radical ring opening was investigated over a wide range of conditions ([Cp 2 TiCl 2 ]/[ epoxide] = 1/1-6/1, [Cp 2 TiCl 2 ]/[Zn] = 1/0.5-1/8, [isoprene]/[epoxide] = 20/1-1000/1, T = 70-130 °C in THF and dioxane), to reveal a linear dependence of molecular weight on conversion, linear kinetics and moderate polydispersities up to high conversions, with an optimum in initiator efficiency, rate and polydispersity for [epoxide]/[Cp 2 TiCl 2 ]/[Zn] = 1/3/6-1/4/8 at 90 - 110 °C. NMR studies demonstrated the epoxide initiation and the stereoselectivity of a conventional radical polymerization. Furthermore, random and block copolymers with styrene could also be obtained.


To the Editor.— Your EDITORIAL, "Aspirin and Bleeding" (218:89, 1971) repeats a timely warning, but in a rather faint whisper rather than the clarion trumpet call that is appropriate. Mention is made of the "crippling effects of aspirin" in patients with hemophilia, multiple telangiectasis, peptic ulcer, and in neonates, but no mention is made of fatal or near fatal gastric hemorrhage occurring after moderate doses of aspirin in otherwise normal, healthy individuals. Personal experience with such an occurrence is worth relating. A healthy man, age 67 years had taken aspirin, 10 grains, once or twice daily for several years for muscular and joint aches and pains that followed vigorous exercise. An attack of acute prostatitis with chills and fever to 104 F (40 C) was treated by nitrofurantoin (Furadantin), 100 mg four times a day, rest in bed, and aspirin, 10 grains three or four times daily, to reduce


The lack of motivation in employees is a problem that affects their work performance, having complications in their emotional and psychological health, regardless of the size or type of organization, productivity is reduced and the consequences are reflected in raising operating costs in general terms. This research sought to identify the degree of motivation that collaborators have in medium-sized companies in the city of Xalapa, Veracruz, Mexico, specifically in the functional areas of the organizational structure, aimed to make the diagnosis under the analysis of the theories of Motivation and human needs of Maslow to inquire in a general way how motivated they are and if they meet their needs according to this theory. A non-experimental, exploratory, descriptive and quantitative research was carried out; For this, a duly validated motivational instrument with 20 items divided by dimensions was administered, with indicators that measure the elements of the theory of needs and the motivation of the collaborators. The analysis units were determined based on an infinite population that was represented by 96 medium-sized companies, which were specifically surveyed in the functional area, being industrial, service and commercial companies. The results obtained showed that the surveyed personnel did not feel that their needs for recognition or self-fulfillment were mostly met, in the same sense, the statistical hypothesis test showed that more than 60% of the collaborators were not motivated by their work environment. Based on the aforementioned, it was concluded that it is necessary to establish clear goals both at the organizational and personal level in order to take advantage of the potential of the collaborators, in the same sense, design incentive programs, recognition of personal achievements and, if necessary, changes in the approach to work.


In the university, the wide use of the network language laboratory makes the foreign language teaching become more and more networked, diverse, and informational. But many universities only focus on the devotion and construction of the hardware. When constructing the language laboratory, they ignore the future development, which results in the wasting of valuable equipment'. We have to develop the network language laboratory enough to make the equipment have their value.


We present a spectral analysis of higher-order texture advection in combination with Back and Forth Error Compensation and Correction (BFECC). Semi-Lagrangian texture advection techniques exhibit high numerical diffusion, which acts as a low-pass filter and tends to smooth out high frequencies. In the spatial domain, numerical diffusion leads to a loss of details and causes a blurred image. To reduce this effect, higher-order interpolation methods or BFECC can be employed separately. In this paper, we combine both approaches and analyze the quality of different compositions of higher-order interpolation schemes with and without BFECC. We employ radial power spectrum diagrams for different advection times and input textures to evaluate the conservation of the spectrum up to fifth-order polynomials. Our evaluation shows that third-order backward advection delivers a good compromise between quality and computational costs.


The properties of inorganic nanomaterials in adsorption, catalysis, and photoluminescence are commonly affected or dominated by particle size, surface ligand, and ligand coverage; however, it has been long remaining challenging to generally understand underlying physical and chemical principles with a unified model. In this review the electronic-level principle that can unify the structure-property relationships concerning nanomaterial surface science is systematically illustrated, based on a chemisorption model through competitive orbital redistribution from bulk energy bands into surface chemisorption bonds. The physical nature of enhanced surface reactivity by size reduction lies in weakening lattice confinement on surface atomic orbitals and amplifying the effects of other structural factors such as defects. Nanoscale cooperative chemisorption (NCC) model reveals the general physical principles driving size- and coverage-dependent ligand-nanomaterial interactions owing to orbital competitions between bulk energy bands and surface adsorption bonds. NCC theory can interpret the impacts and trends of ligand-induced surface effects on electronic states, bonding strength, and the emission energy and quantum yield of both surface fluorescence like ligand-capped Au nanoclusters and bulk intraband fluorescence like CdSe quantum dots. Competitive orbital redistribution provides a new electronic perspective to unify the physical principles driving nanomaterial surface science.


Motivated by applications to the categorical and geometric local Langlands correspondences, we establish an equivalence between the category of filtered $\mathcal{D}$-modules on a smooth stack $X$ and the category of $S^1$-equivariant ind-coherent sheaves on its formal loop space $\widehat{\mathcal{L}} X$, exchanging compact $\mathcal{D}$-modules with coherent sheaves, and coherent $\mathcal{D}$-modules with continuous ind-coherent sheaves. The equivalence yields a sheaf of categories over $\mathbb{A}^1/\mathbb{G}_m$ whose special fiber is a category of coherent sheaves on stacks appearing in categorical traces, and whose generic fiber is a category of equivariant constructible sheaves.


Objective:To study research intensive care unit(ICU)infection and drug resistance of pathogenic bacteria and to provide a basis for the rational use of antibiotics.Methods:Statistically analyze the strains of specimens from patients in ICU during January,2006 to December,2007.Results:G bacilli accounted for 57.50% in all the pathogens,of which acinetobacter baumannii accounted for 17.70%,and pseudomonas aeruginosa accounted for 15.10%.Sensitivity test showed that the level of resistance was a little higher.Of which the G~+ bacteria accounted for 31.10%,staphylococcus aureus accounted for 11.30%,staphylococcus epidermidis accounting for 13.60%,and the fungi was 11.40%.Conclusion:The key to reduce bacterial resistance and drug-resistant is the strengthening the management of infection in ICU the monitoring bacterial resistance,and the rational use of antibiotics.


A natural circulation vertical pressure tube type boiling light water cooled and heavy water moderated reactor design is advanced in terms of safety philosophy. One of the important passive design features of this reactor is that the decay heat removal is achieved through natural circulation of primary coolant through Isolation Condenser (ICs) submerged in Gravity Driven Water Pool (GDWP). During transients leading to hot shutdown, the ICs are intended to remove decay heat with the help of GDWP. The ICs reject heat in this large pool of water. This sets natural circulation and further thermal stratification. The stratification may affect heat removal through ICs and further cooling of fuel. For effective heat removal through the ICs, it is very important to analyse the stratification phenomenon and its challenges to problem of heat removal in long term to maintain core coolability. For thermal hydraulic safety analysis of reactor system, system codes like RELAP5 and CATHARE are predominately used. These system codes have detailed 6-equation two-phase 1-D models. The thermal stratification in GDWP is basically a 3D phenomenon. So far, thermal stratification problem was simulated using 1-D model and use of such model to simulate this phenomenon poses a challenge in terms of proper simulation of effective heat removal. There is a limited 3D capability in CATHARE code. It is desirable to have verification of CATHARE 3D modelling before integration of this model with complete reactor model and further integrated transient safety analysis. The paper discusses the detailed 3D modelling of GDWP in CATHARE and simulation of stratification phenomenon during decay heat removal transient along with results. INTRODUCTION The advance reactor [1] is a light water cooled heavy water moderated pressure tube type boiling water reactor. During normal reactor operation, full reactor power is removed by natural circulation caused by thermo siphoning phenomenon. The main heat transport system transports heat from fuel rods to the steam drums using boiling light water in a natural circulation mode. The necessary flow rate is achieved by locating the steam drums at a suitable height above the core. By eliminating nuclear grade primary circulating pumps and their drives, and control system, all event scenarios initiating from non-availability of main pumps are therefore excluded besides providing economical advantage. The above factors result in considerable enhancement of system safety and reliability. During normal shutdown, decay heat is removed by natural circulation in the main heat transport circuit and the heat is transferred to ultimate heat sink through main condenser. The isolation condenser system removes heat during non-availability of the main condenser. Under this scenario, core decay heat is removed by eight isolation condensers (ICs) submerged in the gravity driven water pool. The pool acts as a heat sink for passive decay heat removal system. Four isolation condensers are capable of removing 6% full power core heat (decay heat at reactor trip). Passive valves are provided on the down stream of each isolation condenser. These valves get activated at a set steam drum pressure, and establish steam flow by natural circulation between the steam drums and corresponding isolation condenser under hot shutdown. The steam condenses inside the isolation condenser pipes immersed in the GDWP and the condensate returns to the core by gravity. The IC rejects heat in large pool of water. This sets natural circulation and further thermal stratification [2]. This thermal stratification may affect the heat removal through ICs and effective cooling of fuel. For effective heat removal through the ICs, it is very important to know this stratification and its challenges to problem of heat removal in long term to maintain core cool ability. The deterministic safety analysis of reactor system is performed mainly using system code such as RELAP5 [3], CATHARE [4]. These system codes have detailed 6-equation two-phase 1-D models. 1-D model of heat rejection in large pool of water has limitation in simulating the thermal stratification phenomenon, which is 3-D Transactions, SMiRT 21, 6-11 November, 2011, New Delhi, India Div-III: Paper ID# 477 2 in nature. To assess the heat removal characteristics of the pool under stratification is important to maintain the core temperature under the limit. The system code CATHARE has 3-D capability [5], which can be used along with usual 1-D reactor model to assess the heat removal through IC path under reactor shutdown with unavailability of main condenser. Such scenario can occur in reactor under Station BlackOut (SBO). In this paper, 3-D model of the Gravity Driven Water Pool (GDWP) is developed in CATHARE. Further, a transient analysis with IC in operation for decay heat removal is analysed. The results are analysed for thermal stratification phenomenon. GRAVITY DRIVEN WATER POOL (GDWP) Gravity Driven Water Pool (GDWP) is located in the dome region of the reactor building and contains 8000 m3 of water inventory to cater to the various requirements as mentioned above. The GDWP consists of 8 compartments, each interconnected to each other. Each compartment of GDWP contains one Isolation Condenser (IC) for core decay heat removal during shutdown. Each compartment of GDWP is provided with outlet nozzle having perforations at various elevations for low-pressure injection into the core during LOCA. There are a number of vent pipes from tail pipe towers for vapors suppression during LOCA. The GDWP recirculation and cooling system, consists of 4 loops, each loop consists of a pump for recirculation of GDWP inventory to prevent biological growth in GDWP, a heat exchanger to maintain the temperature of GDWP inventory below 40°C, a bypass purification line consisting of a filter & an ion exchanger to remove the suspended and ionic impurities so as to maintain the crud concentration within limits and a chemical addition tank. These loops operate in rotation with 2 loops operating at a time, which are capable of meeting 100% duty. A tank is provided outside reactor building for inventory makeup or draining of single compartment of GDWP during maintenance. Fig.1: 3-D wire frame view of the GDWP The GDWP has many passive roles during LOCA transient and station blackout. During LOCA, it is used for low-pressure injection in the core, act as a vapour suppression pool to suppress V1 pressure transient, further V2 heat removal through passive containment cooling feature. During station blackout, GDWP provides large water inventory as a sink to remove the decay heat of the reactor core in passive manner using ICs. 3-D MODEL DEVELOPMENT OF GDWP To modal GDWP in CATHARE, The Cartesian coordinate is used instead of cylindrical coordinate to model the geometry. While doing this, the height, length and inventory of the compartment are kept constant. The Transactions, SMiRT 21, 6-11 November, 2011, New Delhi, India Div-III: Paper ID# 477 3 arc portion of the compartment is being replaced with equivalent width. In the modified geometry, IC is placed in the center. This process is illustrated in Fig. 2. Fig. 2: Cartesian geometry development of one GDWP compartment The three-dimensional model of CATHARE is based on the "porous" two-fluid six equations model [5]. One set of mass, momentum and energy balance equations is written for each phase. Additional equations can be used to take into account the presence of noncondensable gases, and also to model the turbulent diffusion of one or both phase(s). The model of turbulence for each phase is a two-equation K-ε model. Fig. 3: 3-D model of GDWP in CATHARE The x-direction i.e. length of the GDWP compartment is divided in 7 meshes having length 2.6857 m (except 1 mesh i.e. 2.6858 m). The y-direction representing the width of GDWP compartment is dived in 4 meshes Transactions, SMiRT 21, 6-11 November, 2011, New Delhi, India Div-III: Paper ID# 477 4 of 3.0, 2.8, 2.8 and 3.0 m length. The z-direction representing the height of GDWP compartment is divided in 10 meshes of 0.55, 0.55, 0.3, 0.4, 0.4, 0.4, 0.4, 0.3, 0.85, 0.85 m length. The IC header and IC tubes are present in several meshes of GDWP 3-D model. An approach similar to the modelling of porous media has been used for this kind of application. Thus, one defines a scalar porosity field, which gives the relative volumes occupied by the fluid and by the structures. Regarding the Descretisation, this porosity field is defined on both the scalar nodes (i.e. volumetric porosity) and the vector nodes (i.e. surface porosity). These porosities are calculated according to the geometry and the mesh and are imposed by the user through the input deck. The volumetric momentum and energy transfers between the solid structures and the fluid are also taken into account by appropriate terms in momentum and internal energy balance equations. The 3-D model of the GDWP is shown in Fig. 3. The space Descretisation of the equations follows the finite volume approach for all the scalar balance equations and the finite difference approach for the momentum balance equations. This difference is due to the use of the non-conservative form for the momentum balance equation. The time Descretisation of the equations is based on the semi-implicit scheme. RESULTS AND DISCUSSION A transient of decay heat removal from the reactor core with the help of ICs rejecting heat in GDWP is simulated using 3-D GDWP model in CATHRE. A constant 3% decay heat conditions for 7200 sec has been considered which is conservative in nature considering gradual fall of decay heat with time in reality. The results are plotted in ZX and ZY direction. There are four planes in ZX direction in planes ZX2 And ZX3 ICs and in ZY direction in ZY3 and ZY5 planes ICs are laying. The results of the analysis are described below; Temperature Profile The temperature profile is shown in Fig. 4 to Fig. 7


Purpose
In several recent judgments, the Jordanian Court of Cassation has found that using arbitration to resolve individual labor disputes is null. The aforementioned approach which constituted a departure from the well-established former approach that the same court has followed has been confirmed by the new amendments that the Jordanian Arbitration Act has seen in 2018. In view of this, this study aims to highlight and critically analyze the above-mentioned court's decisions and the new amendments pertaining to arbitration clauses from a Jordanian Labor Law perspective and the distinct characteristics rooted in it to find out the extent to which applying arbitration in such a context is acceptable or not.

Design/methodology/approach
To examine how effective are the approaches followed by the Jordanian courts and the legislator in ruling the unacceptability of arbitration clauses in individual labor contracts and to observe to what extent it has been successful in this relation, this work makes use of the secondary data available in this regard as the main method to complete such an examination and this includes the relevant different legislations, court's decisions and jurisprudence. By critically analyzing and comparing the various data contained in these secondary data sources, this work will identify the problems associated with such approaches and accordingly bring up different recommendations and conclusions.

Findings
While the current author do largely agree with the conclusions that have been reached recently by the aforementioned courts, it is submitted that these courts and the legislator have not dealt with such a matter in an adequate and comprehensive manner as they should have spilled more ink on this area of law. Furthermore, this work argues that while the principles that necessitate arbitration shall be respected, the distinct characteristics of the labor law warrant a more careful approach than actually followed by the competent authorities.

Originality/value
Taking into consideration the recent different approaches followed by the Jordanian courts and legislator in ruling the unacceptability of arbitration clauses in individual labor contracts, it would not be a surprise to say that there is no comprehensive and updated scholarly work which has either examined such different approaches or addressed its implications. Accordingly, this work derives its originality and value from being the first and most updated work that examines and addresses such a thorny matter.


The Surface Plasmon Resonance (SPR) is a label-free, highly sensitive and real time sensing technique and has been extensively applied to biosensing and assay for decades. In a conventional SPR biosensor, a prism is used to create the total reflection in which the evanescent wave can excite the surface plasmon mode at the metal-dielectric interface at certain angle, at which condition the reflectivity of incident TM-polarized vanished as measured by a far-field photodetector. This is the optical detection of surface plasmon resonance. In this research, zinc oxide (ZnO) was used as the dielectric thin-film material above the gold surface on the glass substrate to form a co-plane Schottky diode; this structure is designed to be an alternative way to detect SPR. The strength of plasmonic field is possible to be monitored by measuring the photocurrent under the reverse bias. According to our experimental results, the measured photocurrents with TM-polarized illumination (representing the SPR case), TE-polarized illumination (non-SPR case) and no illumination conditions under DC -1.5V bias are -76.158mA (2.5μA), -76.085mA (3.6μA) and -76.089mA (3.4μA), respectively. Based on the results, we have demonstrated this Schottky diode based co-plane device has the potential to be used as the SPR detector and provides a possible solution for the need of a low-cost, miniaturized, electronically integrated, and portable SPR biosensor in the near future.


More than 2 million individuals in the U.S. suffer traumatic brain injury each year, and their chronic cognitive problems involve significant


For current microelectronic integrated systems, the design methodology involves different steps that end up in the full system simulation by means of electrical and physical models prior to its manufacture. However, the higher the circuit complexity, the more time is required to complete these simulations, jeopardizing the convergence of the numerical methods and, hence, meaning that the reliability of the results are not guaranteed. This paper shows the use of a high-level tool based on Matlab to simulate the operation of an artificial neural network implemented in a mixed analog-digital CMOS process, intended for sensor calibration purposes. The proposed standard tool enables modification of the neural model architecture to adapt its characteristics to those of the electronic system, resulting in accurate behavioral models that predict the complete microelectronic IC system behavior under different operation conditions before its physical implementation with a simple, time-efficient, and reliable solution.


It is almost certain by now, that the bronze statue of Bodhisattva Seishi (Mahasthamaprapta) discovered in 1989 at the storeroom of the musee Guimet, is in fact a work of Kosho, the fourth son of Unkei, who started it in 1231 at the same time as the two other elements of the Amida's Triad assigned to the West-Altar in the Kondo of Horyuji. Placed on the right of the principal Altar which ornaments the famous Shaka's Triad, executed in 623 by master Tori, and symmetrical of the one at the East, where the statue of Buddha Yakushi is placed dated at the time following the great conflagration of 670, this West-Altar was built during the proceedings of reconstruction at the end of the VIIth century. In spite of the engraved text, behind it's principal personnage's aureole, leading to believe, that the Amida's Triad was raised in the place of another, former one, stolen at the end of the XIth century — or, by the terms of a traditional variation as soon as the Xth century — , it seems that the West-Altar had to wait 1232 to receive the group of images corresponding to its original intention. So far, the Altar has been adorned with different kind of statuettes. When the Horyuji decided to charge Kosho with the execution of the original Amida's Triad, the artist did not fail to put forth a mark of potent expression as well as his remarkable realistic manner, but as it had to be in harmony with the former existing sculpture of the Kondo, he was constrained to work in an archaistic manner. Under the double influence of the development of Amidist's faiths and a certain reversal to the origin of Japanese Buddhism, the Prince Shotoku, considered formerly as the incarnation of the great compassionate Kannon, knew then a renewal of popularity. The origin of the inspiration placing the Amida's Triad in the Kondo has probably to be searched among a Religious like Kenshin, well-known compiler of an important mass of information about the prince's life accomplished in 1238 (Shotoku-taishi den shiki), an the instigator of a mandala centred on the Prince himself (Shoko-mandara). All things considered, the most fundamental place is granted to this Triad in the beliefs, expressed by the religious dispositif of the Kondo both in the Shotoku-taishi den shiki and in the mandala in question: stating her name, the mother of the Prince, widow of the Emperor Yomei (the Horyuji, it has to be recalled, has been built initially for his recovery) is nominated as a "descended trace" of Amida; the Prince, himself, like one of Kannon and his wife the Lady Takahashi, alias Kashiwade, like one of Seishi. This is the conception having apparently presided over the source of the statue, Emile Guimet acquired later. He bought it as a Chinese work suspecting nothing about the Holy and glorious origin. The circumstances of this object's disappearance from the Monastery has still not been resoluted in the present state of knowledge. This article is the presentation of the texts relating to this question.


Training and education is important in negotiation. For a trained negotiator, good results are the consequence of knowing when to follow to his/her instincts and when to employ negotiation theories or use a combination of them. As the economics within Greater China become more internally linked together, it becomes increasingly important to understand the nuances of each culture encompassed by this term. There is very little comparing the negotiation styles of Chinese who live in Taiwan, Hong Kong, and China among themselves. To fill the gap, the present research focuses on negotiations style comparison by education among Chinese in Taiwan, Hong Kong, and China. The population was chosen from public companies listed under the stock markets. Data was collected using an online survey technique. SPSS was used to conduct data analyses, and a variety of statistical measures were used, including descriptive statistics and MANOVA, and coefficient alphas was reported for modified instruments in order to address reliability and validity of the instrument. The results indicated that three dimensions-intuitive, normative, and analytical-had a significant relationship affected by education among the three regions. The researcher suggests that the negotiators still need to be trained in body language, strategies, temper control, international manners, and customs. A better knowledge of negotiation should be helpful in understanding business and in realizing which negotiation styles are most appropriate for a particular country. The appropriate negotiation skills can bring more competitive advantages and benefits.


Typescript letter from the Honorary Assistant Secretary of the Anti-Partition of Ireland League regarding Mr Shannon's wish to be removed from the list of members. Dated 10 March 1939.


Human cells tolerate UV-induced cyclobutane pyrimidine dimers (CPD) by translesion DNA synthesis (TLS), carried out by DNA polymerase η, the POLH gene product. A deficiency in DNA polymerase η due to germ-line mutations in POLH causes the hereditary disease xeroderma pigmentosum variant (XPV), which is characterized by sunlight sensitivity and extreme predisposition to sunlight-induced skin cancer. XPV cells are UV hypermutable due to the activity of mutagenic TLS across CPD, which explains the cancer predisposition of the patients. However, the identity of the backup polymerase that carries out this mutagenic TLS was unclear. Here, we show that DNA polymerase ζ cooperates with DNA polymerases κ and ι to carry out error-prone TLS across a TT CPD. Moreover, DNA polymerases ζ and κ, but not ι, protect XPV cells against UV cytotoxicity, independently of nucleotide excision repair. This presents an extreme example of benefit-risk balance in the activity of TLS polymerases, which provide protection against UV cytotoxicity at the cost of increased mutagenic load.


The objective of this paper is to analyze new fo rms of local territorial partnerships developed under the territorial cohesion policy pro moted by the European Union. In this context, the future of cohesion policy and the growing importanc e of territorial cohesion led to the initiating of the micro-regional projects in order to reduce economic and social disparities. The promotion of regional policies based on local agreement is dedicated to c reate partnerships in order to start projects for l ocal development that involve civil society, municipalit ies, regions, private sector, experts, or private citizens. These partnerships are presented as infor mal organizations, created by cooperation at local level of public institutions, with social and econo mic actors stated aim to develop community consistently using all the resources offered by the ir territory. Such forms of cooperation can be foun d i several places in the world, but with a greater foc us in Europe, and their main purpose is to promote community participation and sustainable development , gaging citizens and organizations in taking decisions at local level. The study aims to clarify the concept of "local action group" and to analyse th effects of public private partnership on territor ial development for the project initiated in the Hâ rlău region. This project groups 12 administrative-terri o ial units from Iaşi County, developed with the support from the European program LEADER.


This book is the fifth in a series which began in 1991, covering new metabolic pathways. The book begins with a listing of major functional groups, and this is followed by an overview of the metabolic pathways that are of particular interest, including those of particular toxicological interest. In this volume, novel metabolic activation pathways are described for valproic acid (an anticonvulsant) and menthofuran (a constituent of mint). The main body of the work consists of short descriptions of th~ !love! metabolic pathways, together with the ongtnal references. The index at the end is crossreferenced with earlier volumes of Biotransformations, and indexes are also provided on the basis of key functional groups and reaction types. This is a particularly helpful feature. I hope that this series continues, although, in the long-term, the extensive cross-indexing of reactions and .functional groups may best be presented by loadmg the information onto a database, in addition to presenting it as a book. This would enhance its value and ease of use as the information accumulates. I believe that this series is an esse!ltia~ text for any worker engaged in the elucidation of new metabolic pathways, and should become established as a standard text.


This paper presents a theoretical model of lending which emphasizes the role of asymmetric information and total debt service obligations between creditors and debtors. The analytical approach is based upon that of Stiglitz and Weiss (1981); however, emphasis here is placed upon collateral policy aspects of credit contracts as compared to the interest rate policy aspects. It is demonstrated that under certain market constellations, even assuming a completely flexible collateral banking policy, the credit market may be characterized by a disequilibrium situation.


This paper discusses Henry James's acceptance and criticism of French realism in 'The Art of Fiction'(1884). Some Jamesian critics regard 'The Art of Fiction' as "a manifesto of aestheticism" or as an essay written under the direct influence of French realism. It is true that we can find not a few influences of French realism in his essay. Under its influence James discusses the position of the novel as a higher form of art, the unlimited freedom of novelists, and the criticism of didacticism (or the confusion of art and morality). Even James's major theory of the novel as a "representation of life" is suggested under the influence. But these relations of influence are nothing but a superficial affair. James's true strategy lies in undermining their own weaknesses and suggesting his own theory of the novel by using their terms. Thus, the significance of 'The Art of Fiction' lies in his assertion that "the air of reality" or truth to life cannot be achieved through the naturalistic imitation of life but through the "selection whose main care is to be typical, to be inclusive." This is the true base on which he can criticize the suffocating dullness or flatness of French realism which describes exactly only some confined ranges of reality. James's true intelligence as a critic can be found in his suggestion that the creativity of art is the creativity of life itself, as F. R. Leavis says.


The use of heart rate variability (HRV) in research has been greatly popularized over the past decades due to the ease and affordability of HRV collection, coupled with its clinical relevance and significant relationships with psychophysiological constructs and psychopathological disorders. Despite the wide use of electrocardiogram (ECG) in research and advancement in sensors technology, the analytical approach and steps applied to obtain HRV measures can be seen as complex. Thus, posing a challenge to users who may not have the adequate background knowledge to obtain the HRV indices reliably. To maximize the impact of HRV-related research and its reproducibility, parallel advances in users' understanding of the indices and the standardization of analysis pipelines in its utility will be crucial. This paper addresses this gap and aims to provide an overview of the most up-to-date and commonly used HRV indices, as well as common research areas that these indices have shown to be very useful, particularly in psychology. In addition, we also provide a step-by-step guide on how to perform HRV analysis using an integrative neurophysiological toolkit, NeuroKit2.


A comparative study was done on the structure and tribological properties of arc sprayed coatings and arc surfaced layers of TRIP steel. An iron alloy feedstock was used due to its ability to form a metastable austenite structure in both sprayed and surfaced layers that can be transformed to hard martensite by an applied external load. Microstructural and phase analysis and adhesive and abrasive wear tests were conducted to evaluate the coatings and surfaced layers. Differences in properties are explained based on input energy parameters.


We use density functional theory to examine methane dissociative adsorption on lanthana to produce H and CH3 bonded to the surface. Previous work suggested that the binding energy of a Lewis base and a Lewis acid to an oxide exceeds by far the value expected from adding the binding energies of the same compounds chemisorbed alone. This rule suggests that the fragments (H and CH3) formed by the dissociative adsorption of methane on an oxide will adsorb so that they could benefit from this strong acid–base interaction. To do this, one fragment must bind to oxygen and the other to a cation. Such a configuration should have lower energy than the one obtained by binding both fragments to oxygen, even though each fragment prefers to bind to oxygen when it binds alone. We suggest that this behavior is encountered in most systems.


Abstract – The concept of Service-Oriented
Architecture (SOA) can be used as a foundation for
establishing an integrated Intelligence System, which
would be based on services as software components. It
offers better coordination among institutions involved
in intelligence, thus providing increase of intelligence
effectiveness. In this article, the central focus is placed
on determining measurement tools that allow
evaluation of the service's potential within an
Intelligence Information System (IIS).
The defined metrics' aim is to estimate the
accessibility status of services in IIS, thus facilitating
the decision-making process prior to initializing a
request for intelligence data gathering. Taking into
account the individual service characteristics of
reliability and cost, we gain additional insight into both
momentary and periodic, weighted accessibility status
of the system. By employing these estimations we hope
to enhance our ability to understand, and consequently
control and improve the results produced by our IIS.
Keywords – intelligence; decision support; service;
accessibility; metric;


Abstract Chebyshev inequalities provide bounds on the probability of a set based on known expected values of certain functions, for example, known power moments. In some important cases these bounds can be efficiently computed via convex optimization. We discuss one particular type of generalized Chebyshev bound, a lower bound on the probability of a set defined by strict quadratic inequalities, given the mean and the covariance of the distribution. We present a semidefinite programming formulation, give an interpretation of the dual problem, and describe some applications.


Offset polygons wereformally defined and used in [BBDG] in solutions to a number of geometric problems with ap plicationa to robot localization and geometric tolerrmcing. A similar construct was also explored by Aicholaer et al. ~AAAG, AA] and given the name stmight skeletons. In [BDG], a polygon-oflset diw!unce function was firat formally defined based on theee offset polygons (or straight skeletona) in the case when the polygon is convex. Some properties of this distance function were explored in that paper, as was the Voronoi diagram based on this distance function. Figure 1 shows a sample polygon P along with two offset polygons, one inside P and one outside P. Note that the inner offset has fewer edges than P.


Objective To explore the possibility to harvest full length phrenic nerve under thoracoscope and the effects of phrenic nerve transfer on hand function reconstruction in the total root avulsion of brachial plexus. Methods Phrenic nerve transfer was applied in 3 cases of the total root avulsion of brachial plexus. Full length phrenic nerve was mobilized with its vascular tissue pedicle in the thoracic cavity under thoracoscope and harvested till the phrenic nerve end near the phrenic muscle. 13 to 22cm phrenic nerves were withdrawn out of the second intercostal space to the proximal level of arm. In two cases, transfered phrenic nerve was anastomosed with the anteromedial part of the ulnar as motor drive nerve. In one case, phrenic nerve was transfered to be anastomosed with the obturator nerve anterior branch of the translated gracilis muscle for reconstruction of finger and thumb flexion. Results Two patients with the phrenic nerve and the motor branch of third to sixth intercostal nerves transfered to the ulnar nerve, accepted the oral administration of immunosuppresant FK506. The hand intrinsic muscles were examined by electromyogram and regenerated electric potentials were found by the 12 months postoperatively. In one of them, the hand intrinsic muscle contraction started by the 15 months after the phrenic nerve transfer. In another female case, contraction of the translated gracilis muscles for reconstruction of finger and thumb flexion started by 7 months after the phrenic nerve transfer. She was followed up 12 months and her muscle strength was M3. Conclusions The full length phrenic nerve harvested under thoracoscope can be applied as motor drive nerve transfer in the treatment of total root avulsion of brachial plexus. The function of the finger and thumb flexion can be reconstructed effectively in a short time. There are signs that the hand intrinsic muscle may also be reinnervated and start restoring its contraction function.


This essay shows that marriage and the refusal of marriage proposals are essential in Jane Austen's four novels,Pride and Prejudice, Mansfield Park, Emma and Persuasion (1983). The society which Au ...


: In 1996, the European Council Directive 96/29/EURATOM pointed phosphate fertilizers to have a potentially negative influence on the environment from the radiation protection point of view. Fertilizers along with irrigation and crop rotation were the milestones that allowed to increase agricultural productivity. Firstly based on natural materials such as compost, manure, fish processing waste, etc., and since the 19th century created synthetically, fertilizers caused a boom in crop yield and helped to propel global food production, especially after World War II. In this work the concentrations of ²¹⁰Po, ²²⁶Ra, ²³²Th, ⁴⁰K, and ¹³⁷Cs in selected fertilizers and soil samples were determined. The results were used to calculate the annual addition of natural radionuclides and increment of the external radiation exposure caused by the use of studied fertilizers. Soils intended for different types of crops were sampled in early spring when no vegetation had occurred yet. Analysed fertilizers were those with which the soil was previously fertilized. For gamma radionuclides, a high purity germanium detector GX3520 from Canberra was used. The polonium concentration was determined by radiochemical separation followed by measurement by means of alpha spectrometry. The spectrometer used in this study was equipped with 450 cm² PIPS detector from Canberra. Obtained results showed significant differences in radionuclide composition between phosphate and nitrogenous fertilizers (e.g. the radium equivalent activity for phosphate fertilizer was 207.7 Bq/kg in comparison to <5.6 Bq/kg for nitrogenous fertilizer). The calculated increase of external radiation exposure due to use of phosphate fertilizer ranged between 3.4 and 5.4 nG/h, which represents up to 10% of the polish average outdoor exposure due to terrestrial gamma radiation (45 nGy/h).


HE VALUE AND PURPOSE OF A LITERARY-CULTURAL CANON CAN SEEM LIKE OLD questions in the ever more distant wake of the fin de siècle culture wars. But these questions remain open, not just because they negotiate the always-contemporary dialectic of stasis and change, but also because the twentyfirst century's global sensibility and increased attention to Asia and the Middle East have compelled renewed scrutiny of the universalist assumptions underpinning Western Canon curricula. Adam Kotsko's title 'What is the Western Canon Good For?', a question that can be asked dismissively or in earnest, captures the uncertainties we continue to feel when devising curricula that claim to cover a shared cultural tradition.


Wenduermiao Group is located at central section of Inner Mongolina of China, which may be subdivided in ascending order into the Sangdalaihuduge Formation and Haerhada Formation. It has been usually considered to be an ophiolite suite, but there has been a controversy on its era. According to filed investigation, Wenduermiao Group includes not only ophiolite but also lithological association of intra-ocean island arc:basalt, andesite-basalt and andesite. Therefore Wenduermiao Group is a suit of complex including ocean-crust slices,intra-ocean island arc and otherwise with different ages and geneses. Based on recent dating of the LA-MC-ICPMS U-Pb zircons from Wenduermiao Group, the intra-ocean island arc metamorphic andesite from upper part of Sangdalaihuduge is dated at 470±2Ma, and the main ages of detrital zircons from two samples(10NM142,10NM143)of Haerhada Formation range from 445Ma to 480Ma and the youngest age of detrital zircons from 10NM143 is mainly 424~438Ma, indicating that there are at least some Middle Silurtion strata in the Haerhada Formation. Our results, in conjunction with the available geological data including ophiolite age (497~477Ma), metamorphic times(446±15Ma~453±1.8Ma) of high-pressure metamorphic rocks and evidence that Late Silurian Xibiehe Formation overlies unconformably Wenduermiao Group, suggest that times of Sangdalaihuduge Formation is possibly from Cambrian to Late Ordovician and times of Haerhada Formation from Late Ordovician to Middle Silurtion. It is thus concluded that Wenduermiao Group is a suit of metamorphic complex formed in Cambrian to Middle Silurtion.


Ore deposit(body)modification is one of emphasis about mineral exploration study.It plays an important guiding role on mineral exploration and evaluation that the authors do much detailed researches on ore deposit(body) modification.Based upon the outcome of geology work in recent years,the authors put overview carefully in some aspects such as the modification controlling factors,the modification objects,the modification results.The changes after the modification are classified as following six aspects:①the modality and occurrence of the orebodies.②the structure and component of the ore.③the ore grade.④the scale of the ore-deposit.⑤the type of the ore-deposit.⑥the geological abnormity of the ore-deposit.And summarized study on laws of modification from deposits and orebodies has great meaning to the development with the mineralization theory system and guidance function of metallogenic forecasting and prospecting.


A positive dry film photoresist and a method for preparing the positive dry film photoresist are provided to improve sensitization velocity, developing contrast, sensitivity, resolution and the adhesion to a substrate. A positive dry film photoresist comprises a support film; and a positive photoresist resin layer formed on the support film, wherein the positive photoresist resin layer is formed by coating a composition comprising an alkali-soluble resin, a positive photosensitive compound, a sensitivity enhancer, a first solvent and a second solvent on the support film and heating the composition until the second solvent is removed, and comprises an alkali-soluble resin, a positive photosensitive compound, a sensitivity enhancer, and a first solvent. The first solvent remains in the composition after the second solvent is removed by heating and acts as a plasticizer in a photoresist resin layer when a dry film photoresist is prepared.


COPYRIGHT © 2023 Ciurleo, Tavares-Júnior, Vieira, Braga-Neto and Oriá. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Do APOE4 and long COVID-19 increase the risk for neurodegenerative diseases in adverse environments and poverty?


Research within the domain of applied linguistics is at the moment lively and vigorous. Exciting work is being conducted in many settings by scholars trained in diverse areas of specialization. Certainly the inclusion of separate strands in (at least) psycholinguistics and sociolinguistics is now obligatory in most graduate programs in linguistics, bilingual education, foreign language education, or English as a second or foreign language, whereas the subjects were just beginning to be introduced two decades ago. The vitality of the Linguistic Society of America (LSA), the American Council on the Teaching of Foreign Languages (ACTFL), Teachers of English to Speakers of Other Languages (TESOL) and other organizations bodes well for the strength of our discipline. Annual or semi-annual meetings of each of these groups are well attended and offer broad, stimulating programs for participants. These organizations directly or indirectly sponsor a range of scholarly publications widely distributed to a broad membership.


This chapter follows Carlos from her time as a graduate student in the Columbia-Princeton Electronic Music Center to her early professional career as a recording engineer with Gotham Studios. At Columbia, she studied with electronic music pioneers Vladimir Ussachevsky and Milton Babbitt, learning to compose music with magnetic tape and the RCA Mark II Synthesizer. Carlos met Robert Moog for the first time in 1964 at the Audio Engineering Society convention. They worked together as Moog developed modules for 900-series analog synthesizer. Carlos also began seeing Dr. Harry Benjamin, author of The Transsexual Phenomenon, in his office in New York.


With the development of drone technology, carrying cameras, Lidar and other sensors has gradually become a hot research topic in recent years. However, at this stage, the dron e power grid inspection mainly relies on manual, requires staff to spend a lot of time to shoot, and because the manual operating standards are not uniform, for the follow-up inspection dat a processing has brought great inconvenience. Therefore, base d on the image-speed-angle speed three-stage PID control algo rithm, the autonomous patrol drone is designed. The system o btains position feedback and foreign object information throu gh OpenMV camera, and then obtains the data input image P D controller, the controller output expects speed to angle serial controller, and finally the output is fed back to the drone mot or to achieve the purpose of the patrol line, and at the same ti me, the foreign object recognition algorithm is designed to real ize the identification of the cable foreign body in the process of patrol. The experimental results show that the stability and fo reign object recognition accuracy are high in the course of dro ne patrol.


Aim. The study aims to evaluate the government policy implementation in tackling the global pandemic and framing universal policies for responsible governance. It also measures the impact of training interventions and non-training implications in containing the spread of COVID-19 at the grassroots level.
Methods. The samples were drawn empirically from pathological tests conducted over 23 weeks to precisely examine the success of the State Government's approach in lowering COVID-19 mortality and spread. Through trend analysis, the outcome has been predicted. The study establishes a link between acknowledged ideas and government practices, providing insight into how relevant the implementation of planned state-craft programs is.
Results. The findings indicated that government-imposed policies account for timely pandemic containment, and even a tiny developing state lacking advanced medical facilities and technology can set an example in combating the epidemic.
Conclusions. The temporal analysis is based on the inputs acquired from government publications and other sources, allowing us to assess policy initiatives that encompass training interventions and non-training implications as prioritized by the State Government. The paper shows that a good emergency preparedness and response system is needed to prevent huge losses in any sector. This includes the already-struggling health sector, which India needs to put first to avoid more tragedies.


The self-weight collapsibility eliminated after prewatering processing the ground in No.10 Pumping Station of Guhai Extend Irrigation Area in Ningxia,but the water in groundwork soil drained away very slowly,and groundwork loading capacity was comparatively low,which seriously affected the schedule of engineering construction. For figuring out how to solve the problem,the powder-spraying-stake in No.10 Pumping Station was adopted again. The application of the powder-spraying-stake in prewatering soft ground made the groundwork loading capacity come to a designed request.The experience may be used for reference to the same kind of construction project.


Is a digital platform for remote pre-treatment assessment perceived as useful and able to fulfil the needs of patients and clinicians?

 The digital platform was found to be of high quality, useful, and answer the expressed needs of the targeted audiences in cross-cultural samples.

 Infertility is a life crisis. It takes on average 3.2 years to be diagnosed, 1.6 years to access a specialist, and 2.2 years to complete treatment. The pre-assessment phase is time-consuming, costly, often disruptive to the patient's life, and may require traveling abroad. Patients need organized care where they can schedule/order tests, access information about their specific health conditions, and reach out to professionals. On the other hand, clinicians find themselves trying to assess a large number of patients before initiating treatment abroad without having a unified platform where they can review the patient's clinical history and treatment plan.

 Study I explored patients' experience with pre-treatment care and their perceived usefulness of the Patient's Portal. An online questionnaire of 25 questions was used. Study II explored clinicians' perceived usefulness and quality of the Doctor's Portal. A semi-structured interview was conducted and an online questionnaire of 17 items was used. Both questionnaires had multiple options, Likert-scale, and open-ended items. The studies followed a cross-sectional design. The data were analyzed using IBM SPSS Statistics, Version 28.0.

 Study I had a cross-cultural sample of 59 women (M = 37.2, SD = 4.9 years). 41% are trying to conceive for more than 24 months, 89.8% were in a heterosexual relationship, and all were undergoing treatment/pursuing a clinic. The internal consistency of the questionnaire is α=.97. Study II had a cross-cultural sample (N = 8) of clinic leaders, all from different clinics. The interview questions were open-ended to capture unprompted opinions. The internal consistency of the questionnaire is α=.94.

 Study I: People who took >4 weeks to have tests done/get the results scored significantly higher values than people who took less time in terms of how much they had to pay, struggled to find where to have the tests done, had difficulty managing emotions, and would've preferred their clinic had scheduled the testing for them. Overall, 61.02% reported the testing had been disruptive to their lives. Regarding the perceived usefulness of the platform, means >4 and a mode of 5 on a scale of 1-5 were obtained. We also found that regardless of the woman's age or how long she's been trying to conceive, she'd benefit from having this platform available.
 Study II: 75% made mention the high-quality of the platform, 50% said it would improve their current practice, covered information comprehensively, and was user-friendly, and 37.5% said it would make the process of diagnosing patients faster. Suggestions were used to adapt the platform. Regarding the quality questionnaire, the means varied between 7.86 and 9.14 (SD between .69 and 1.11) and the mode between 8 and 9 on a scale of 1-10. The inter-rater reliability coefficient was .94. This means the perceived high-quality and usefulness of the platform were consensual.

 Small sample sizes condition the extrapolation of the findings. Further studies of the perceived usefulness and quality of the Patients' Portal and Doctors' Portal after the implementation of the digital platform are required.

 The digital platform for remote pre-treatment assessment is currently available and being used by clinicians and patients. In the future it, can be further developed to develop and train an Artificial Intelligence algorithm to Diagnose & Predict Fertility Treatment Outcomes with Personalised Patient Pathways.

 not applicable


By the time David Copperfield appeared in 1850, most Victorians felt that heaven was unimaginable without their worldly identity and relationships. But while evangelical ministers and authors of death-consolation literature promised a social and marital reunion in heaven, they also worried about the status of remarriage in an eternally present afterlife. This essay first examines a variety of complex Victorian responses to the promise and problem of a conjugal heaven and then unfolds the eschatology of David Copperfield. The seemingly conservative language of Victorian angelology unexpectedly allows for David's fantasy that he will share heaven with his two sequential wives.


This study is about the role of 'Lembaga Perkreditan Desa (LPD') towards the social and economic conditions of desa pakraman Padangtegal's community. The objective of this study is to find out the role of LPD in traditional village in Bali. This study uses mix methods which combines the quantitative and qualitative methods, the instruments of this study is questionnaire, in-depth interview and focus group discussion. The result of this study shows that the role of 'Lembaga Perkreditan Desa (LPD)' towards the social and economic condition of desa pakraman Padangtegal's community is not only profit oriented but also social oriented, therefore 'Lembaga Perkreditan Desa (LPD)' has a positive impact to the condition of the community of desa pakraman Padangtegal.


A study was conducted to know the carbon sequestration potential in biomass of Melia dubia under semi-arid region of Karnataka. Plantations of 2, 4, 6 and 8 year old grown in different soil types such as black and red were selected and biometric observation were recorded at the time of start of experiment and at 12 months after start of experiment. Plantations grown in black soil recorded the higher values for carbon sequestration in above ground biomass, below grown biomass and in total biomass as compared to red soils. Among the age gradations, plantations of 8 year old recorded the higher values for biomass carbon as compared to rest of age gradations. From the results it can be concluded that black soil have higher potential to sequester higher carbon in total biomass in Melia dubia.


As book history has become a more widely studied subject, the need for introductory texts for students (and for others) has become more urgent. The discipline is well served by specialist literatur...


Previous studies have shown that downregulation of ubiquitin-specific protease 1 (USP1) can inhibit cell proliferation and promote apoptosis, indicating that targeting USP1 with drugs is a potential treatment for cancer, especially breast and ovarian cancer. In this study, we performed virtual screening on a database containing about 1.37 million molecules using the pharmacophore model, multiple precision molecular docking algorithms, molecular mechanics/generalized born surface area (MM/GBSA), strain energy, and ADMET screening methods. We found that Z28551960, Z423064076, Z1037335610, and Z1129923146 compounds showed excellent performance in terms of binding energy with USP1, ADMET property evaluation, and binding dynamics with USP1, had high potential as USP1 inhibitors, and were identified as hits in virtual screening. In addition, we demonstrated for the first time through molecular dynamics simulations that those molecules can enhance the structural flexibility of the USP1 protein and reduce its structural compactness, providing a basis for protein conformational changes. In summary, our discovery of potential USP1 inhibitors with novel scaffolds provides a theoretical basis for further development of USP1 inhibitors.


Scene Graph is high level representation of a 3D world that can be used to manage objects in a 3D graphics engine. As the number of polygons and entities in the 3D scene increases, so does the complexity for efficient management of the scene. Sending all the geometry to the graphics hardware is a huge waste of processor power and memory bandwidth. It also hinders the quality of the 3D scene. Therefore, efficient management of different type of objects is the key to fast rendering. Use of Scene Graphs for graphics engines differs in design and implementation but the general features of Scene Graphs are used in most engines. In this paper we present a Scene Graph management technique utilizing different hidden surface removal methods for faster and more efficient rendering of interactive 3D environments.


In this new so-called millennium,
all wack unconscious poets shall be stoned.
So I suggest that all poetry enthusiasts and people in the audience
bring any types of rocks, pebbles or projectiles from your home.


The paper critically examines the New Keynesian explanation of hysteresis based on the role of long-term unemployment. We first examine its analytical foundations, according to which rehiring long-term unemployed individuals would not be possible without accelerating inflation. Then we empirically assess its validity along two lines of inquiry. First, we investigate the reversibility of long-term unemployment. Then we focus on episodes of sustained long-term unemployment reductions to check for inflationary effects. Specifically, in a panel of 25 OECD countries (from 1983 to 2016), we verify by means of local projections whether they are associated with inflationary pressures in a subsequent five-year window. Two main results emerge: i) the evolution of the long-term unemployment rate is almost completely synchronous with the dynamics of the total unemployment rate, both during downswings and upswings; ii) we do not find indications of accelerating or persistently higher inflation during and after episodes of strong declines in the longterm unemployment rate, even when they occur in country-years in which the actual unemployment rate was estimated to be below a conventionally estimated Non-Accelerating Inflation Rate of Unemployment (NAIRU). Our results call into question the role of long-term † A preliminary version of this work has been presented at the 17th STOREP Conference (October 2020) and the 4th ASTRIL International Conference (December 2020). We thank for their comments Prof. Luca Fantacci and all the participants to our sessions. The usual disclaimer applies. * Research Fellow, Department of Economics, Roma Tre University ** Research Fellow, Department of Economic and Social Sciences, University Cattolica del Sacro Cuore *** Department of Economics, Roma Tre University unemployment in causing hysteresis and provide support to policy implications that are at variance with the conventional wisdom that regards the NAIRU as an inflationary barrier. https://doi.org/10.36687/inetwp156


Lifelong leaners are intrinsically motivated to embed learning activities into daily life activities. Nevertheless, finding a suitable combination of the two is not trivial since lifelong learners have to face conflicts of time and location. Hence, lifelong learners normally build personal learning ecologies in those moments they set aside to learn making use of their available resources. On the other hand, the advent of Near Field Communication (NFC) technology facilitates the harmonization in the interactions between the digital world and daily physical spaces. Likewise, NFC enabled phones are becoming more and more popular. The contribution of this manuscript is threefold: first, scientific literature where NFC has been used with a direct or indirect purpose to learn is reviewed, and potential uses for lifelong learners are identified; based on these findings the Ecology of Resources for Lifelong Learning is presented as suitable setup for the scaffolding of learning activities with NFC augmented physical spaces; finally, this ecology is piloted and different learning scenarios are proposed for further extension.


Through cold state modeling tests a study was conducted of the influence of an offset mounted exhaust pipe on the performance of a cyclone separator installed on a circular fluidized bed boiler. The results of the tests indicate that the offset mounted exhaust pipe has markedly enhanced the efficiency of the cyclone separator along with a reduction of its total resistance. In view of this the adoption of a suitably offset exhaust pipe can be considered as one of the major methods for improving the performance of the cyclone separator.


Student population is a special group in social and professional terms, which is characterized by the complexity of socio-psychological influences, getting professional education as the main sphere of activity, territorial concentration, commonality of interests, age homogeneity. Student youth is a group of high risk of various diseases. Today, the level of student health raises serious concerns of experts due to the high prevalence of various health abnormalities. The physical and psychological state of students depends on a large number of factors. Among them are lifestyle, often associated with inadequate physical activity, a high expansion of bad habits (smoking, drinking, drug abuse and substance abuse), irrational nutrition, prolonged neuro-psychological stress caused by a significant amount of educational programs, chronic and prolonged lack of time, which is needed to absorb a huge amount of information, worries, in connection with examinations in session, heavy information load, prolonged work on the computer, and a lot of work in the classroom. These factors contribute to the decrease of the body's adaptation capabilities. Health-saving orientation of the educational environment in higher education is possible when creating conditions for the formation of skills to preserve and strengthen the health of students. At the most typical age for students (17-18 years old) researchers observe increased tension of adaptation mechanisms due to neurohumoral changes and specific psychological content, which conditions the critical stage of ontogenesis. Students' adaptation to the conditions of the university includes three periods of acute, transitional and steady course of the adaptation process. The successful adaptation of students is provided by their physiological and intellectual readiness, as well as the formation of emotional, motivational and volitional sphere.


On the basis of the analytical method of the rigid foundation considering time effect,a program was made to calculate the rigid foundation and work out the changes of its inner force and deformation with time.During the loading,the S~lgt curves show "S" shape.The counterforce from the base of the rigid foundation is stronger in the middle than at the edges.The load supported by the pile in the rigid foundation becomes less.The program is proved to be reliable and can be used to study the time effect of soil.


The Bullmastiff is very powerfully built with a broad wrinkled head and fairly short, square, dark muzzle. The v-shaped wide-set ears are pendant and dark colored. It has a short, slightly rough coat that comes in brindle, fawn, or red, often with black markings on the head. Height: 24-27 inches


This paper summarizes and synthesizes the existing literature relevant to pedestrian receptivity toward Fully Automated Vehicles (FAVs). Objectives of this review are to identify research gaps that need to be filled and to propose a roadmap for future research. Since FAVs are operated by software and hardware, with no human driver required, interactions between other road users and FAVs must be understood, and potential risks must be addressed. This is especially true for pedestrians, who often exhibit unpredictable behavior and are one of the most vulnerable road-user groups. A comprehensive review was conducted of 1) different aspects of pedestrian interaction with forthcoming fully automated vehicles, and 2) the existing research approaches (surveys and simulator studies) for investigating risky pedestrian behavior as well as public acceptance of fully automated vehicles. The review identified three major gaps in pedestrian research: 1) lack of a pedestrian behavior questionnaire for FAV research, 2) lack of a validated pedestrian simulator for FAV research, and 3) lack of research investigating pedestrian design suggestions for FAVs. A future research roadmap to facilitate investigating pedestrian receptivity toward FAVs was designed. Achieving pedestrian acceptance of FAVs will require investigation of pedestrian risks and needs by transportation researchers and communication of the results to vehicle manufacturers and regulatory agencies. This review will be useful to transportation researchers and automated vehicle manufacturers to help guide planning for future design and production of FAVs in order to ensure their successful implementation.


Although ozone (O3) plays a crucial role in screening the Earth's surface and lower atmosphere layers from the ultraviolet radiation, troposphere ozone is proven to have negative health effects on the human body and is one of the greenhouse gases. The objective of this study was to perform a measurement-based assessment for determining whether the concentration of ozone is within admissible limits, or exceeded, in Silesia Province and does not pose a threat to the local population. The data provided by the Voivodship Inspectorate for Environmental Protection in Katowice were used in the analysis. The received data constitute the result of 8-h measurements of concentrations of ozone at selected air monitoring stations of the Silesian province. The locations of three monitoring stations were found to be useful for the aim of this research; one site is situated in a rural background area; another one is located in a medium-sized city and the Katowice station is representative for an urban background situation. We used cluster analysis, weighted pair group method using arithmetic averages (WPGMA) and Chebyshev distances to test the hypothesis and compare empirical distributions in the general population. The alarm level has not been exceeded in indicated measurements stations in Silesian Voivodship in the period 2015–2017 (averaging time 1 h: 240 µg/m3 for 3 h). The target level was exceeded in 2015 at all three measurements stations and in the following years at one station (in Zloty Potok, 2016, and in Katowice, 2017). Each year, the largest number of exceedances occurred in August. The results clearly indicate a lack of hazards for the general population's health in terms of increased concentrations of ozone in the city centers and outside. The results confirm that environmental conditions (i.e., landform, the area surrounding monitoring station) have a significant influence on the ozone level.


This paper describes a new, accurate, completely digital, configurable and computer-aided system for the simultaneous measurement of magnetic hysteresis loops and Barkhausen noise in a wide range of frequencies (from 0.01 to 80 Hz). The importance of the correct choice of the data acquisition card to have enough resolution in both hysteresis loop and magnetic Barkhausen noise measurements is emphasized. Both the magnetic induction signal to construct the magnetic hysteresis loop and the Barkhausen noise are computed by digital processing (numerical integration and digital filtering, respectively) of the induced electromotive force signal. Some results of hysteresis loops and RMS envelopes of the magnetic Barkhausen noise signal are presented to show the capability of the system to work at different excitation frequencies without changing any hardware.


Since the expression of genes for platelet-derived growth factor (PDGF)-A and PDGF -receptor are reciprocally regulated in vascular wall cells after balloon injury, we have investigated the ability of specific vasoactive molecules or growth factors to reproduce the injury pattern of gene expression in cultured rat smooth muscle cells (SMCs) and assessed the effect of inactivating a-thrombin on injury-induced expression of PDGF-A mRNA by vascular wall cells in vivo. The molecules investigated, to which vascular SMCs may be locally exposed after mechanical injury, included vasoactive factors (aand ,-adrenergic agonists, serotonin, histamine, angiotensin II, and endothelin) and growth factors (PDGF-AA, PDGF-BB, basic fibroblast growth factor, insulin-like growth factor, epidermal growth factor, and a-thrombin). In cultured rat SMCs, only a-thrombin (0.1-100 nM), among these compounds, produced the pattern of transiently increased PDGF-A and decreased PDGF f-receptor mRNA. PDGF-B chain mRNA levels remained undetectable in these cultured SMCs. The dependence of these changes in gene expression on the proteolytic activity of a-thrombin was shown by the interruption of altered gene expression or DNA synthesis after incubating the cultured SMCs with covalently inactivated a-thrombin using D-Phe-ProArg chloromethyl ketone, a synthetic direct active-site irreversible inhibitor of a-thrombin. Continuous intravenous infusion of this synthetic antithrombin into baboons for 6 hours (100 nmol/kg per minute maintaining constant plasma levels of 3.0+0.5 ,ug/ml) after inducing balloon-catheter arterial injury also prevented the threefold increase in expression ofPDGF-A mRNA characteristically exhibited by untreated mechanically injured vessels. We conclude that a-thrombin initiates an injury pattern of PDGF ligand and receptor gene expression both in vitro and in vivo. The importance of a-thrombin in the development of vascular lesion formation induced by mechanical injury and the possible usefulness of interrupting a-thrombin activity in the prevention of restenosis remain to be determined. (Circulation Research 1992;71:1285-1293)


A 3-D numerical simulation of steady flow in the full scroll passage of a Kaplan turbine was conducted to study the effects of four different types of scroll buttress.The results show that the number and shape of scroll buttresses produce a great effect on the hydraulic parameters and turbine performances,particularly on the uniformity of vertical inflow profile at the runner inlet where the flow rate in the vane spacing increases in upward direction.This effect can extend to the flow rate in the spacing of stay vanes.The buttress tail that twists toward the worm inlet,could effectively guide the flow toward the worm and distribute the flow more evenly along the circumference.Thus through a better design of scroll buttresses the efficiency and stability of hydraulic turbine is improved and the life of turbine will be extended.


This is a report of a case of abdominal pregnancy (a rare condition). Lack of antenatal care resulted in late presentation. Persistent abdominal pain, weight loss and pallor were the main clinical features. Presence of this triad in pregnancy should raise the suspicion of abdominal pregnancy. Key Words: Abdominal pregnancy Annals of African Medicine Vol.3(4) 2004: 195-196


This paper presents the challenges of implementing a bare-metal hypervisor without using hardware virtualization features. This choice is dictated by two reasons: (i) some processor do not include virtualization instructions, (ii) in the context formal verification, the proof relies on good behavior of the hardware. Thus eliminating hardware features will let us have a more precise proof. Implementing virtualization features in hardware is a complex work: the instruction set remains large, and despite of the documentation, some behaviors are not obvious, if not undefined. Moreover, doing this in software forces us to freeze the guest to perform work, decreasing performances. We implemented a software hypervisor that has the particularity to run the guest systems in privilege mode. Before that, the hypervisor dynamically analyze the guest code and runs it after setting breakpoints on sensitive instructions. To perform the analysis, we extracted the whole ARM and Thumb instruction set to identify sensitives instructions, which has to be handled by the hypervisor. In order to preserve acceptable performances, we only track code running on privileged mode. Thus, guest kernel run at the same level of privileges as the hypervisor. We evaluated the performances of our approach using micro-benchmarks and macro-benchmarks to evaluate the impact of the process on a piece of code and on a whole system. The results show that, when running a guest that performs pre-emptive scheduling and running its tasks in user mode, our hypervisor performs with a reasonable overhead: from 0.3 % to 15 % overhead on several synthetic benchmarks. We finally provide several ideas for further optimization and a direction for future work.


Aim of the study: To study the effect of Silymarin against Intracerebral (i.c.) LPS induced Neuroinflammation in mice. Material and methods: The effect of Silymarin was examined against Intracerebral (i.c.) LPS induced Neuroinflammation in mice. The behavioural study was performed by using models Morris water maze. Various biochemical parameters such as proinflammatory cytokines (TNF-α) as indicator of Neuroinflammation, Acetyl cholinesterase (Ach E) activity as marker of cholinergic activity and malonaldialdehyde ( MDA) and glutathione (GSH) as marker of oxidative stress were estimated. LPS was used in dose of (5μg/5μl) for Neuroinflammation in mice was used. Silymarin was administered in two different doses of 25mg/kg and 50mg/kg. Result: Silymarin exhibit a significant (p<0.05) decrease in latency time (LT) in Morris water maze model indicating memory enhancing activity of the drug in dose dependent manner. Also, (TNF-α) were significantly (p<0.05) reduced in mice brain as well as brain indicating antineuroinflammatory activity of drug. MDA level and Ach E activity was reduced significantly (p<0.05) in treated group in comparison to LPS treated group indicating anti oxidant effect of Silymarin. Conclusion: In conclusion, the present study indicated that Silymarin could ameliorate memory impairment induced by lipopolysachharide. Intracerebral microinjection of LPS ((5μg/5μl) significantly induced Neuroinflammation in mice and cause release of cytokines (TNF-α), free radical generation and oxidative stress in the brain regions. Treatment with Silymarin in two different doses (25mg/kg and 50 mg/kg) effectively attenuated LPS induced Neuroinflammation, oxidative stress and cognitive impairment. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 6.041 Volume 5, Issue 10, 1433-1447 Research Article ISSN 2278 – 4357 *Corresponding Author Priyanka Sonker Dept of Pharmacology, Hygia institute of Pharmacutical Education & Research, Lucknow. Article Received on 21 Aug 2016, Revised on 10 Sep 2016, Accepted on 30 Sep 2016 DOI: 10.20959/wjpps201610-7914


Causal representation learning exposes latent high-level causal variables behind low-level observations, which has enormous potential for a set of downstream tasks of interest. Despite this, identifying the true latent causal representation from observed data is a great challenge. In this work we focus on identifying latent causal variables. To this end, we analysis three intrinsic properties in latent space, including transitivity, permutation and scaling. We show that the transitivity severely hinders the identifiability of latent causal variables, while permutation and scaling guide the direction of identifying latent causal variable. To break the transitivity, we assume the underlying latent causal relations to be linear Gaussian models, in which the weights, mean and variance of Gaussian noise are modulated by an additionally observed variable. Under these assumptions we theoretically show that the latent causal variables can be identifiable up to trivial permutation and scaling. Built on this theoretical result, we propose a novel method, termed Structural caUsAl Variational autoEncoder (SuaVE), which directly learns latent causal variables, together with the mapping from the latent causal variables to the observed ones. Experimental results on synthetic and real data demonstrate the identifiable result and the ability of the proposed SuaVE for learning latent causal variables.


Recommendation letter from James H. Cook, a New York City Minister, for John Sykes Fayette to Rev. President Storrs, of Hudson College, Ohio.


In the present work, using powder metallurgy method, mechanical alloying and extrusion, the metal matrix composite material Al–Zn–Mg–Cu/10% SiC was obtained. Phase transformations occurring during heat treatment were studied. After deformation aluminum solid solution, MgZn2 and SiC are present in the composite material. The X-ray phase analysis and TEM results showed that when the composite material is heated for quenching, the MgZn2 phase is completely dissolved. Study of the aging kinetics showed that the peak of aging of the composite material was achieved in 15 h, which is much faster than in the matrix alloy (24 h). After aging, the solid solution decomposition products appear in the form of a metastable η'- phase (MgZn2), looking like rods located in three mutually perpendicular directions <100> Al.


Tourism cultural courses of vocational colleges are supposed to accord with skill-oriented and application-oriented training objectives of vocational colleges,and teaching of the courses should attach importance to practicality.In reality,the problems of practical teaching are found in textbooks,the evaluation system,teaching methods and training bases,etc..Therefore,the construction of tourism cultural courses is expected to develop the stereoscopic teaching materials of tourism cultural courses,construct the practical teaching system,optimize teaching methods and the evaluation system and perfect "school-enterprise cooperation" teaching modes so that students' vocational skills will be improved to achieve the training objectives.


The objectives of this study were to compare the behaviors, postures, and heterophil to lymphocyte ratios (H:L) for laying hens when offered a Ca pre-molt treatment and low energy molt diets versus feed-withdrawal (FW) during and postmolt. A total of 144 Hy-Line W-36 hens (85 wk of age), housed 3/cage, (413 cm/hen) were used. Six treatments were compared in a 2 (fine versus coarse Ca pre-molt treatment) by 3 (FW, soybean hulls [SH], or wheat middlings [WM] molt Presented, in part, in the 2008 Iowa State University Animal Industries Report, Ames, Iowa. Graduate student and primary author, Department of Animal Science, Iowa State University. Nutritionist, Hy-Line International, Dallas Center, Iowa. Professors, Department of Animal Science, Iowa State University. Graduate student, Department of Animal Science, Iowa State University. Assistant Professor and author for correspondence, Department of Animal Science, Iowa State University, firstname.lastname@example.com. –––––––––––––––––––


The study was carried out to establish in vitro microtuber production from leaf and petiole explant cultures of Pinellia ternata. Culture conditions were optimized by investigating the effect of plant growth regulators, different media, and gelling agents on the efficiency of microtuber indurtion. Among the different combinations of plant growth regulators tested, the combination of 0.1 mg/l 2,4-Dichlorophenoxyacetic (2,4-D) and 0.5 mg/l 6-benzylaminopurine (BAP) showed the highest yield fer microtuber production from leaf (3.9) and petiole (4.7) explant culture on MS medium far 6 weeks. SH(Schenk and Hildebrandt) medium was the most effective medium for microtuber induction and the half strength SH medium was better than SH medium for microtuber production from both leaf and petiole culture. Gelrite was better than agar in the formation of microtubers and 4% Gelrite showed the highest number of microtubers per explant frome leaf (5.9) and petiole (7.8) culture. Germination rate of microtubers after cold storaged for one months long was 86% from in vitro culture and 43% from autoclaved soil.


In Virgil's third eclogue, the goatherd Menalcas responds to his challenger Damoetas by offering as his wager in their contest of song a pair of embossed cups, caelatum diuini opus Alcimedontis (Ecl. 3.37), decorated with a pattern of vine and ivy. In the middle of this design, he says, are two figures. One is the astronomer Conon, and the other—at this point Menalcas, afflicted with a sudden loss of memory, professes to have forgotten the name of the second figure, and breaks off into a question (Ecl. 3.40-2): quis fuit alter, | descripsit radio totum qui gentibus orbem, | tempora quae messor, quae curuus arator haberet? Various candidates for the identity of this second astronomer have been suggested, one of the most favoured being Eudoxus of Cnidus, whose Phaenomena had been versified by the Hellenistic poet Aratus. In 1930 it was proposed by Léon Herrmann that Menalcas in fact answers his own question in his reference to curuUS ARATor at Ecl. 3.42: the solution to Virgil's riddle is already written into the question, in the form of the anagram of Aratus concealed within these two words. Strictly speaking, Hermann notes only that 'Arator au v. 42 évoque le nom d'Aratos'; he and later exponents of the theory tend to ignore the preceding '-us'—but there seems no reason to exclude it if an allusion to the Greek poet is to be seen in the two following syllables.


A Department of Political Science was established at the Florida State College for Women in 1926 under the headship of Dr. Bessie Randolph. In 1933 when Dr. Randolph left the college to become President of Hollins College, Political Science was made an autonomous division within the Department of History, Geography, and Political Science. Not until the women's college became co-educational by act of the legislature in 1947 did Political Science again have independent departmental status. Dr. Marian Irish who had been director of the Division of Political Science in the Florida State College for Women since 1933 then became head of the Department of Political Science at Florida State University.


Abstract The present study describes the length-weight relationships and condition factor of a freshwater fish of Dawkinsia filamentosa (Valenciennes, 1844), southern Western Ghats, Tamilnadu, India. A total of 103 fishes were sampled from four mid-order streams (Thalaianai, Iluppaiyar, Gadana and Gundar). Fish samples were caught from March to May 2013. The linear regression parameters 'a' and 'b' of the length-weight relationship were estimated as W=aL b are presented. The result indicates that the coefficient of 'b' values ranged from 2.13–3.74, with the greater 'b' value obtained for the habitats from Gundar River. The condition factor (K) mean value ranged from 1.37–1.53 with the highest K=1.53 at Gundar river. The determinants suggest the growth and condition factors of D. filamentosa populating the downstream river of the Tamiraparani river are excellent and fittest when equated to lower order streams. Keywords: Condition factor, Dawkinsia filamentosa, length-weight relationship, Tamiraparani river Cite this Article Sabaridasan A, Edwinthangam P, Soranam R. Studies on Length-Weight Relationships and Condition Factor of Endemic Fish Dawkinsia filamentosa (Cypriniforms: Cyprinidae) from Southern Western Ghats, India. Research & Reviews: Journal of Ecology. 2015; 4(1): 1–7p.


This study is dealt with fault tolerant control of five phase permanent magnet (PM) machines. The main objectives are to increase the output power while eliminating the generated torque ripples. As a new aspect, the effect of available neutral connection is evaluated on the output power and torque ripples.


Introduction:
 Mutations in BAG3 result in dilated cardiomyopathy with cardiac fibrosis. Currently, the role of BAG3 in non-myocyte cell types is not known. We tested the hypothesis that BAG3 controls cardiac fibroblast (CF) function and that the loss of fibroblast-specific BAG3 is deleterious, using cells and engineered cardiac tissues (ECT) derived from pluripotent stem cells (iPSC).

 Methods:
 Isogenic iPSCs containing homozygous knockout (KO) of BAG3 were differentiated into CFs. Mass spectrometry measured the effect of BAG3 loss on CF proteome. EdU staining and flow cytometry were used to assess CF proliferation. Transforming growth factor beta (TGF) signaling pathway activity was measured using a luciferase reporter and Western blotting. Affinity purification mass spectrometry (AP-MS) identified high-confidence interactors of BAG3 in CFs. To assess the role of fibroblast-specific BAG3 in cardiac function, conditional KO ECTs were generated using wild-type cardiomyocytes mixed with either wild-type CFs or KO CFs. ECTs were functionally assessed using video microscopy and immunofluorescence. The effects of CF BAG3 loss on tissue gene expression are under study by single nuclear RNA sequencing.

 Results:
 Analysis of proteomics data revealed enrichment of TGF and proliferation pathways in KO cells. KO-CFs had increased proliferation measured by EdU staining and increased SMAD luciferase reporter activity. Western blotting showed that KO CFs have higher expression of TGF beta receptor 2 (TGFBR2) and activation of canonical TGF signaling. AP-MS identified TGFBR2 as an interacting partner of BAG3, suggesting BAG3 mediated TGFBR2 turnover. In ECT, the loss of CF BAG3 caused a reduction in cardiac tissue contractile force (50% reduction, n = 10-12 tissues per group). Immunofluorescence revealed significantly increased tissue fibrosis in CF-KO cardiac tissues quantified by vimentin staining.

 Conclusions:
 BAG3 loss results in increased TGFBR2 signaling and proliferation in cardiac fibroblasts. Conditional KO ECTs demonstrate that CF BAG3 affects tissue function. These data suggest that fibrosis related to BAG3 pathology may be a result of a primary deficiency in CFs rather than a secondary response to cardiomyocyte death.