Simple Summary The advent of immuno-oncology (IO) agents, particularly immune checkpoint inhibitors (ICIs), has changed the treatment landscape of non-small cell lung cancer (NSCLC). We performed a retro-prospective study to describe the patients' outcomes prior to and after the local regulatory approval of pembrolizumab as a first-line (1L) treatment in the real-world setting of an Italian cancer centre. Analyses were performed of a total of 694 patients with no or unknown oncogene addicted tumour, grouped into Pre- (n = 344) and Post- (n = 350) 1L IO populations. The study provides evidence of improvements in overall survival associated with the introduction of 1L immunotherapy, suggesting that receiving immunotherapy in the first-line rather than in the second- or later lines of treatment may be more favourable. Abstract Background: This study provides insights into the treatment use and outcomes of metastatic non-small cell lung cancer (NSCLC) patients in a real-world setting prior to and after the availability of immuno-oncology (IO) regimens in the first line (1L). Methods: Metastatic NSCLC patients, who initiated systemic 1L anticancer treatment from 2014 to 2020, were identified from health records. Patients were grouped into Pre-1L IO and Post-1L IO, according to the availability of pembrolizumab 1L monotherapy at the date of initiating 1L systemic anticancer treatment. Patient characteristics, treatment patterns and outcomes were assessed by the cohort. Overall survival (OS) and real-world progression-free survival (rwPFS) were calculated using the Kaplan-Meier method. Results: The most common 1L treatment was platinum-based chemotherapy regimens in both groups (≥46%), followed by single-agent chemotherapy (27.0%) in Pre-1L IO and pembrolizumab (26.0%) in Post-1L IO. Median OS was 6.2 (95% CI 5.5–7.4) in Pre- and 8.9 months (95% CI 7.5–10.6) in Post-1L IO, while rwPFS was 3.7 (95% CI 3.3–4.2) and 4.7 months (95% CI 3.9–5.7), respectively. Conclusions: Even if a small proportion of patients received a 1L IO, the data showed an improved survival outcomes in the Post-1L IO group.


Person‐centred care (PCC) is increasingly advocated as a new way of delivering health care, but there is little evidence that it is widely practised. The University of Gothenburg Centre for Person‐Centred Care (GPCC) was set up in 2010 to develop and implement person‐centred care in clinical practice on the basis of three routines. These routines are based on eliciting the patient's narrative to initiate a partnership; working the partnership to achieve commonly agreed goals; and using documentation to safeguard the partnership and record the person's narrative and shared goals.


This essay documents labor market and residential segregation in Austin, Texas, in the three decades after World War Two, arguing that despite the city's relatively progressive culture it was as racially segregated as most Northern and Southern cities during the period. In Austin, being progressive usually meant supporting New Deal policies, encouraging strong ties to the federal government, and promoting responsible, nonindustrial growth much more than fighting racial inequality or rejecting the sanctity of private property rights. Segregation, ironically bolstered by federally supported urban renewal, which undermined black property rights, helped maintain a nonindustrial image that city leaders used to market Austin as a pleasant place to live and do business for knowledge workers. The resounding defeat of open housing in 1968 maintained de facto segregation and demonstrated the fallacy of race-neutral housing policies in the South. Today, the deleterious effects of segregation and dispossession are still felt among the city's African American and Latino residents; current economic trends mirror those from the 1960s.


Broadcast scheduling is a fundamental problem in wireless ad hoc networks. The objective of a broadcast schedule is to deliver a message from a given source to all other nodes in a minimum amount of time. At the same time, in order for the broadcast to proceed as predicted in the schedule, it must not contain parallel transmissions which can be conflicting based on the collision and interference parameters in the wireless network. Most existing work on this problem use a limited network model which accounts only for conflicts occurring inside the transmission ranges of the nodes. The broadcast schedules produced by these algorithms are likely to experience unpredictable delays when deployed in the network. This is because they do not take into consideration other important sources of conflict in parallel transmissions, namely the interference range and the carrier sensing range. In this paper we develop a conflict-aware network model, which uses these parameters to increase the probability of scheduling conflict-free transmissions, and thereby improve the reliability of the broadcast schedule. We present and prove correctness of a constant approximation algorithm for minimum-latency broadcast scheduling under this network model. We also present a greedy heuristic algorithm for the same problem. Experimental results are provided to evaluate the performance of our algorithms. In addition, the algorithms are analyzed to justify their performance trends.


In this paper, the projective lag synchronization of delayed chaotic systems with parameter mismatch is discussed. Because of parameter mismatch and projective factor, complete projective lag synchronization can not be achieved. We shall show that the coupled systems can be in a state of projective lag synchronization with a small error level. Several criteria are derived and the error level is estimated by rigorously theoretical analysis. Numerical simulations are also given to verify the analytical approach.


Liuhuanggou coal mine is located in the western of Urumqi,in central areas of Liuhuanggou Mine,and middle reaches of Toutunhe in Junggar Coal Field,administrative divisions under the jurisdiction of Liuhuanggou town,Changji.Based on the detailed analysis of the characteristics of coal and rock,the characteristics of the elemental content of the coal and the coal seam gas parameters in this area show that the content and the abundance of the coalbed methane are rich.Through the specific analysis of geological structure,coal seam depth,rock properties,hydrodynamic factors and depositional system tracts in the study area,this paper summarizes favorable conditions for occurrence of coalbed methane in this area for the coal mine production safety and provides guidance and development of coalbed methane exploration.


This article examines the relationship between religion, transcendence and social bonding. I speculate that the capacity to undergo transcendent experiences facilitated social bonding. Following a discussion of Gorelik's typology of transcendence, it examines the relationship between ritual, transcendence and bonding with an emphasis on singing, dancing and synchrony. It then moves on to explore theory of mind and transcendence. Finally, transcendent emotions like compassion, admiration, gratitude, love and awe will be discussed. I conclude by arguing that transcendence originates from group-level selection.


The ionic model is shown to give a good description of most inorganic materials, such as salts, ceramics, and minerals, regardless of the covalent or ionic character of their bonds. The virtue of the model is its ability to treat chemical bonding using simple electrostatic theory, all the quantum mechanical effects being contained in a short-range potential that is treated empirically. By exploiting the properties of the electrostatic field, a rigorous but simple and intuitive bond model is developed (the bond valence model).This paper shows how the model can be used to explore the structural, chemical, and physical properties of inorganic compounds, including their stability and solubility. The online version of the paper explores further application, showing how the model can be used to understand hydrogen bonding, the factors that determine coordination number, and the unusual chemistry and physics of the new high-tech inorganic solids. The simplicity of the model, the insights it provides without the need for extensive computation, and its wide range of applicability make it particularly useful in teaching as well as research.


The Malay history has been well-documented and much has been written about it by many authors either by the Malays or by the non-Malays as well as the Orientalists. They wrote on various genres of literature, culture and other aspects of the Malays. Some of their findings and conclusions are acceptable. But for some others, because of their adoption of various Western social theories, their application to the study of the Malay society yield untenable results. Syed MuIammad Naquib al-Attas in his influential works such as the Preliminary Statement on a General Theory of the Islamization of the Malay-Indonesian Archipelago, has argued that some of the theories and elaborations particularly by the Orientalists pertaining to Islam and the Islamization of the Malay Archipelago cannot be considered as having achieved the scientific rank of theory, or even in some cases that of hypothesis. As argued by him, the coming of Islam was the most momentous event for the Malays. It constitutes a new period in their history. The process of Islamization generally refers to the process that brought about the phenomenon of historical and cultural impact of Islam upon the Malay world which revolutionized its vision of reality and existence into distinctive Islamic worldview.


AbstractIn this study, an attempt was made to investigate the effect of blending a biodiesel derived from high free fatty acid crude rice bran oil (CRBO) with diesel on the properties as a fuel for compression ignition (CI) engine. Biodiesel [crude rice bran oil methyl ester (CRBME)] blend was prepared by mixing 20% CRBME with 80% diesel on a volume basis. As a result of blending CRBME, the flash point and viscosity of diesel increased by 14 and 3·4% respectively and calorific value decreased by 2%. The distillation curve of the CRBME blend was almost similar as that of diesel and an end point temperature of 337°C was obtained during the distillation of CRBME blend. Blending CRBME with diesel increases the specific gravity marginally and its cetane number increased by 2·3%. From this investigation, it was inferred that the properties of CRBME blend were comparable with that of diesel and it can be utilised as a CI engine fuel. As a renewable fuel its role as a partial substitution of diesel fuel can be vital.


This report compares the drilling of geothermal wells in Iceland and Ethiopia, describing the technology applied and practical activities. For this study, well KJ-32 in the Krafla geothermal field in Iceland (drilled 1998) and well TD-5 in the Tendaho geothermal field in Ethiopia (drilled 1997) were selected. In Krafla 35 wells have been drilled to date and of these 9 wells are directional, as is the case for well KJ-32. The well was drilled from the kick of point (KOP) to final depth with a steerable down hole motor and measurement while drilling (MWD). The target was to produce from the lower reservoir with a temperature of up to 320°C and to reach inaccessible parts of the reservoir below 1100 m. In Tendaho, six wells have been drilled, three deep wells and three shallow wells. Well TD-5 was drilled vertical to a depth of 516 m to intersect a shallow reservoir with a temperature of 240°C. The basic rig parts such as the mast, pumps, and cementing units are quite similar in the two countries and the casing program also. The drill strings make-up and use of logging tools, cementing material and manpower is, however, different. The opportunity was given to me to witness cementing operations at Nesjavellir and at Krafla. This included a three week period on site at Krafla during completion of well KJ-33 and the beginning of drilling well KJ-34.


Based on variational principle, the state-vector equation is established for driving analysis of a laminated beam with piezoelectric actuating layers. The beam are considered as a 2D line solid and the linear element is used. The influence of secondary converse piezoelectric effect (SCPE) on the displacement of the laminated beam is investigated. The state space finite element method is utilized to predict the deflection of the beam considering SCPE or not. If the influence of SCPE is eliminated, the displacement of the clamped beam increase by ∼2.7%. Furthermore, the effects with different PZT/steel thickness ratio considering SCPE are also studied.


The article studies the structure and properties, regularities of their change with the introduction of various fillers and under the influence of gamma – irradiation (γ-radiation). PCM structure study was performed using electron microscopy with scanning electron microscope BS -350 (TESLA) and with X-ray structural analysis method using X-ray diffractometer DRON-3. Shooting of wide-angle X-ray patters was performed in the range of Bragg angles reflection 2Q=5° - 96°. We selected the following properties to study: tensile strength, static tensile modulus. The findings allowed determining: firstly, we determined that based on electron microscopy the supramolecular structural organization depends on the type and percentage of filler in PTFE matrix. Changes take place from lamellar (pure PTFE) to a defective spherulitic (20% of coke) structure. Secondly, we completed X-ray structural analysis (we determined the degree of crystallinity, crystallite size, with parameters а = b in the hexagonal cell, interlayer distance of amorphous area) showed the nature of supramolecular structure changes according to the nature of the filler and subsequent radiation dose. Thirdly there was conducted connection between changes in mechanical strength (tensile strength, statical module of elasticity) and structural changes; the depth of these changes depends on the original supramolecular structure, type and percentage of the filler and the dose of the absorbed radiation energy. The studies will allow change purposefully the supramolecular structure of polymer composite materials to improve the performance properties.


Background To evaluate the power of abnormal resting ECG versus Rose Questionnaire angina and its additive value in predicting 10-year coronary heart disease (CHD) risk in an Iranian urban population with high prevalence of CHD. Methods There were 5101 subjects ≥30 years (2900 women), free of CHD at baseline; they were categorised in to four groups according to their Rose Angina and ECG status for ischaemia as Rose−/ECG−, Rose+/ECG−, Rose−/ECG+ and Rose+/ECG+. HR of CHD was estimated using Cox regression analysis, given Rose−/ECG− as the reference. The authors used Akaike information criterion, C-index and integrated discrimination improvement indices to evaluate the prognostic value of ECG when would be added to Rose Questionnaire. Results During follow-up, 387 CHD events (169 women) were observed. Multivariate analysis showed a HR of 2.59 (95% CI 1.71 to 3.91) and 2.26 (1.48 to 3.44) for Rose+/ECG− group in men and women, respectively. These figures for Rose−/ECG+ were 1.36 (0.90 to 2.05) in men and 2.09 (1.40 to 3.12) in women. There was no any interaction between Rose Questionnaire and gender to predict incident CHD, in age-adjusted analysis. Akaike information criterion, C-index and relative integrated discrimination improvement did not show any difference between models including Rose alone and Rose plus ECG to predict CHD events especially in men. Conclusions Rose Questionnaire as a simple screening tool is equally important to predict incident CHD in both genders. Adding abnormal ECG to angina did not culminate in higher risk for future CHD events.


Young claims that our argument against a seasonal pattern for major depressive disorder fails because we incorrectly assumed that the seasonal pattern corresponds to what has been called "winter blues." In doing so he changes the definition of major depression with a seasonal pattern, thereby contradicting the history of the seasonal pattern modifier, recent and current versions of the DSM, and what is taught in prominent introductory and abnormal psychology textbooks. Despite this divergence, both our research and his share important implications for seasonal affective disorder/major depressive disorder with seasonal pattern (MDD-SP) theory and raise questions about the causal influence of sunlight, and resources devoted to treatment of MDD-SP by supplemental light exposure. Concluding remarks reflect on the process by which the folk theory of winter blues was able to gain and maintain a scientific interpretation.


Foreign direct investment (FDI) has played an important role in the development of Laos since the country embarked on an economic transition and business liberalisation programme in the late 1980s. However, in recent years Laos has witnessed a marked contraction in its cumulative FDI inflows. This article provides a profile of FDI activity in Laos over the past decade and identifies the various factors behind the rise, and subsequent decline, in foreign investment inflows during the 1990s. The article concludes by suggesting some of the ways in which Lao policy makers might seek to revive the country's flagging FDI sector.


BACKGROUND The Hawaii Natural Energy Institute (HNEI) at the University of Hawaii has been tasked to help with the testing of Wave Energy Converters (WECs) of the Fixed Point Absorber (FPA) and Oscillating Water Column (OWC) types, at the U.S. Navy Wave Energy Test Site (WETS) located off Marine Corps Base Hawaii in Kaneohe (Oahu, Hawaii). In addition to field testing of WECs from different private developers, efforts are under way to enhance the capability of the WETS facility by providing guidance with the hydrodynamic design aspects of these machines. This would be accomplished with a suite of simple and high fidelity hydrodynamic numerical models.


A method for detecting a blockage downstream in a tube of a pumped fluid system, comprising the steps of: pumping fluid through the tube with a pumping cycle in one portion of which the distensible components pumped fluid system are elastically expanded to an expanded state due to high fluid pressure therein; obtaining a measurement related to pressure in another part of the pumping cycle in which, in the absence of an obstruction, the distensible components return to a normal state from said enlarged state; and determining that an obstruction exists tube if the measurement exceeds a threshold level.


Before optoelectronic integrated circuits and systems can be produced in high volumes and at low cost it will be necessary to develop for them monolithic integration techniques which can be executed on full wafers and in multiwafer lots. Monolithic processes are also essential to achieving the highest speed and performance from optoelectronic integrated circuits and to insuring robustness and high mechanical reliability. Hybrid techniques can satisfy many near-term needs for optoelectronic integrated circuits, but they involve a great deal of piecework and assembly, thereby increasing cost, introducing performance-limiting parasitics, and decreasing ruggedness. It is monolithic, full-wafer, batch-level processing of monolithic integration that must be the ultimate goal of any program promoting the commercial use of optoelectronics to solve problems in computation, signal processing, data analysis, and sensing. Homogeneous integration of GaN-based high electron mobility transistors and light emitting diodes (HEMT-LEDs) have been attracting more and more attentions over the past years due to their wide application in displays, smart lighting, and high frequency switching applications such as visible light communications.


Long-term regional climate simulations are computationally very 7 costly. One way to improve their computational efficiency is to split them into 8 overlapping time slices, which can then be run in parallel. Although this proce- 9 dure reduces the cost, sufficient spin-up must be left at the start of each slice. 10 In any case, discontinuities will occur due to internal variability where two dif- 11 ferent slices join. In this study, we explore the relative role of spin-up time and 12 internal variability in the discontinuities of overlapping time slice simulations 13 and their effect on the simulated climate. This analysis has implications also 14 for non-overlapping time slices, commonly used in very high resolution climate 15 modelling, where long transient simulations cannot be afforded. We show that 16 discontinuities are negligible for surface and upper-air variables, but they are 17 noticeable in variables with long response times, such as soil moisture or snow 18 depth. For these variables, differences between the slices are mainly attributed 19 to internal variability, but also to insufficient spin-up time, depending on the 20 region. In general, the results show that the overlapping time slice approach 21 is valid to accomplish long term regional climate simulations. 22


Objective
To analyze the epidemiologic characteristics and risk factors for mortality in non-(human immunodeficiency virus, HIV) infected children with pneumocystis carinii pneumonia(PCP).

Methods
The data of non-HIV infected children with PCP diagnosed in Beijing Children's Hospital from January 1, 2006 to December 31, 2012 were collected.They were divided into survival and non-survival group according to the prognosis.The epidemiologic characteristics and risk factors for mortality were analyzed.

Results
Sixteen patients were enrolled in this study.Ten of them survived and 6 of them were non-survived.The basic diseases included malignant tumor in 5 patients and non-malignancy diseases in 11 of them.Compared with the survival group, the non-survival group had a higher average age [(12.00±2.00)years vs.(6.65±4.32)years, P=0.01], higher ratio to need mechanical ventilation (6/6 vs.4/10, P=0.04), lower PaO2/FiO2[(73.88±26.95) mmHg vs.(167.50±97.17) mmHg, 1 mmHg=0.133 kPa, P=0.01] and lower pediatric critical illness score(75.67±5.72 vs.86.40±8.88, P=0.02). There were no differences on sex ratio, kinds of basic diseases, whether with co-infections, the time of immunosuppressant administration, the time from onset to diagnosis, the time from onset to beginning trimethoprim-sulfamethoxazole therapy, PaCO2, white blood cell counts, lymphocyte counts, cell counts, C-reactive protein, and hemoglobin concentrations between the survival and non-survival group.

Conclusion
A higher age, need for mechanical ventilation, lower PaO2/FiO2 and lower pediatric critical illness score were risk factors for mortality in non-HIV infected children with PCP.

Key words:
Non-human immunodeficiency virus infection; Pneumocystis carinii pneumonia; Epidemiology; Risk factors; Mortality; Children


In this literature review the basic links of hemostasis infringements pathogenesis in sepsis are considered in details. Commonly used methods of coagulation infringements diagnosis and correction in septic patients are described. Influence of extracorporal methods of detoxication on a hemostasis system (plasmapheresis, haemosorption, magnetic treatment of blood, etc.) is characterized as well. The carried out analysis of the literature testifies the necessity of improvement of the existing methods and search for new techniques of anticaogulation therapy ofsepsis.


The research was carried out in the Baitiquiri Ecological Reserve, belonging to the municipality of San Antonio del Sur, Guantanamo province, on the date between September 2015 and May 2016. An environmental diagnosis was made that reflected the economic - social reality and the current state of the soils, as well as the floristic diversity of the evergreen coastal and subcostero forest of the investigated site. A total of 40 parcels of 20 x 25 (500 m2) were randomly selected, floristic species present in the different defined strata were counted, height and diameter were measured for the species greater than one meter, and alpha diversity was also determined. and beta, the structure and composition of the species. The results obtained showed that their soils are mostly underdeveloped, of excessive stoniness, (80 %), a rock content of approximately 15%, and unstable slopes ranging from 4.1 % to more than 16.0 %, which facilitates a high degree of potential erosion risk. The most important ecological species for future reforestation or restoration plans are: Phyllostylon brasiliensis C., Coccothrinax sp. and Amyris elemifera, with the species D. nudiflorus in danger of extinction. The comprehensive plan of measures for soil conservation and existing plant formations includes a proposal for anti-erosive measures and management of the forest site, validated and enriched with expert criteria.


Coho salmon Oncorhynchus kisutch are an important subsistence resource for residents of the Native Village of Perryville, but recent returns to local streams (Kametolook, Three Star, and Long Beach rivers) have declined and residents can no longer meet their subsistence needs. Several reasons for the decline have been suggested, including a decrease in carrying capacity from changes in habitat, and over fishing (in-river and in the ocean). This project was implemented to assess the quantity and quality of freshwater habitats used for spawning and rearing by coho salmon in streams near Perryville, and to use these data to conduct a limiting habitat analysis. The survey was repeated on Clear Creek, a neighboring drainage that supports viable runs of coho salmon. Work completed in 2002 includes: 1) completion of a habitat inventory on Kametolook River tributaries and on Clear Creek, 2) sampling of juvenile coho salmon in Clear Creek, 3) escapement monitoring in Clear Creek (weir) and streams near Perryville (walking surveys), and 4) application of a habitat limiting factor model to both systems. Over 43 km of stream in the Kametolook drainage and 12 km of stream in Clear Creek were surveyed in 2002. Habitat composition and quality were similar between systems. Juvenile coho salmon densities in Clear Creek in 2002 were similar to values reported in the literature. Based on length frequency data, it appears that only age 0+ coho salmon were present in Clear Creek (few if any age 1+ were observed). Scale samples will be collected concurrently with length data in 2003 to define the length at age relationships for juvenile coho salmon in Clear Creek. One thousand ninety-seven coho salmon were counted past the Clear Creek weir in 2002. Extrapolated counts of coho salmon were 337 (Three Star River), 342 (Artemie's Creek), and 37 (Cross Creek Slough) in streams near Perryville. The count of adult coho salmon in Clear Creek is a minimum estimate as the weir failed at several critical times during the season. Preliminary results from the habitat limiting factor analysis indicates that Clear Creek can support over 1,100 adult coho salmon, and the Kametolook system can support over 4,000 adult coho salmon. Estimates are considered minimum, as over 3,000 adult coho salmon have been observed in Clear Creek in past years. Introduction The residents of Perryville depend on fish and wildlife resources for subsistence, and salmon (primarily coho salmon Oncorhynchus kisutch) accounts for more than half of the subsistence food they consume (Hutchinson-Scarborough and Fall 1993). The average harvest of coho salmon in the Perryville area from 1993 to 2000 was estimated to be over 1,900 fish, with a range from 993 (1995) to 3,501 (1994) (Alaska Department of Fish and Game (ADFG) 2002). Recent runs of coho salmon in the Kametolook, Three Star, and Long Beach rivers have declined, with escapement estimated at about 200 fish in 1996 (ADFG 1997). Concerns over poor returns and the inability of local residents to meet their subsistence needs motivated the Native Village of Perryville to pass an ordinance that prohibits subsistence harvest in the Kametolook River. In addition, the ADFG engaged in a project in 1996 to rebuild coho salmon stocks in the Kametolook River


he following article is dedicated to the substantiation of the necessity of the
social sphere development and benefits of it's use, which could help firms avoid
financial crisises in future. We grounded the role of banks in the financing cost on
social sphere and pointed possible forms of cooperation between firms and banks in
this field.


OBJECTIVE To investigate parents' cognition and behavior about children vaccination in Qinghai Tibetan pastoral areas inhabited by ethnic minorities, and to provide evidences for developing the effective communication strategies. METHODS Used multi-stages cluster sampling, 703 children's guardians were selected randomly and were investigated by questionnaire. RESULTS The guardians' knowledge on vaccination was not satisfying in agricultural and pastoral areas inhabited by ethnic minorities, for they had weak awareness of positive vaccination. Parents' mastery of knowledge in the vaccination and initiative to take their children to carry out vaccinations in different ethnics were significantly different. Children 's guardians getting EPI knowledge was mainly from the medical staff and television, and wished continue to get the knowledge through these two channels. CONCLUSION It is necessary to develop different communication strategies with varied forms for different population. It is important to strengthen the publicity of immunization knowledge by the medical staff , radio and television channels, and improve the initiative of the public to participate in the immunization program.


By analyzing the existing problems of process planning based on three-dimensional model,definition of process model was introduced into the process planning,and a process planning method driven by process model was put forward.Contrary to traditional method,this method generated machining process from part design model to blank model,in each designing process,a process model was generated,and then the next process based on this process model was designed until the whole process planning was completed.In the procedures of the method,machining feature recognition,machining element generation and machining element cluster were the key elements to influence the automatic process planning.Therefore,a further study on hybrid interactive feature recognition based on process model,a machining element generation method based on knowledge and a machining element clustering method based on fuzzy C-means were implemented.An example of complicated airplane part was taken to discuss the application procedure of the proposed method,which provided a new theory for the process planning based on three-dimensional model.


On the basis of the cotton textile theory,comprehensive description is done to the impact of the cot regarding its structure,elasticity and hardness in relation to evenness uniformity,yarn strength;the hardness of the cot in relation to the friction factor and the linear width of the nipper jaws;the daimeter of the cot and the telescoping tolerance in relation to the quality of the resultant yarn.Analysis is done to the tech-specification of the cot with hi-elasticity and low hardness as well as the theory improve evenness uniformity.Problems with cot manufacturing and maitenance are particularized in addition to the process arrangement.Conclusion is made that ideal draft cot should have good elasticity,small deformation of compression and good abrasion-resistance,good anti-static performance,good humidity balance,stable hardness and ozone resitance against crack so to get good spinnability and good quality of the resultant yarn.


The article substantiates that the symbiosis of marketing and innovation, dictated by the requirements for businesses seeking effective and sustainable development in modern economic conditions, has become a catalyst for the emergence of the concept of "innovative marketing" and related concepts such as "innovation marketing" and "marketing innovations". This has sparked debate among researchers and scholars, whose views on these categories are divided between those who identify them and those who distinguish them. The authors systematized the existing positions of modern researchers and emphasized the lack of agreement in the views of scientists on the essence and content of innovation marketing and innovation marketing, and proposed clarification of their content. According to the results of systematization, the authors identified the following approaches to the definition and characterization of the concept of "innovative marketing": as a process of planning and introduction of new products to the market; as a concept of doing business; as a search for new areas and ways to use the potential of the enterprise; as an activity in the innovation market; as an activity of the enterprise aimed at the formation of new markets. The authors conclude that in scientific publications there is a unity of positions of the authors on the concept of "innovation in marketing". In addition, the authors of the article summarize the approaches to the definition of "innovation marketing": as a tactical innovation marketing; as an activity aimed at finding new areas and ways to use the potential of the enterprise; as an activity aimed at the commercialization of innovations; as a direction of marketing activity, which requires special methods, tools and methods; as an activity aimed at finding new areas of activity; as a combination of actions, receptions, methods, systematic activity of subjects of economic relations concerning development and advancement in the market of new goods. Taking into account the work of modern researchers in the field of innovative marketing and on the basis of their critical analysis, the authors of the article propose a conceptual approach to understanding the essence, components of innovative marketing and types of innovations in marketing.


Objective To evaluate the effect of botulinal toxin type A(BOTOX-A) injection in patienes with lower limb spasticity after stroke.Methods A total of 30 patients with lower limb spasticity after stroke were injected with BOTOX-A in the clinical treatment in recent five years.Three to five muscles of lower extremity were selected to receive local intramuscular injection.The dose was between 50-100 U for each muscle.All injected dose did not exceed 400 U,and the spasticity degree was evaluated with Cohen'standard 4 and 12 weeks later after injection.Results The total effective rate was 90.0%,the excellent effective rate was 86.6%,and the partial response rate was 3.4%.The effect of the patients receiving injection within one year afer stroke was much better than that of those receiving injection one year later afer stroke,and the effective rates were 83.3% and 33.3%,respectively.Conclusion Local intramuscular injection with BOTOX-A can improve the spasticity degree of lower extremity after stroke obviously,and it may do good to the patients as early as possible after strok.


Heterogeneous systems combining several technologies promise the overcoming of several limitations, cost constraints and provide new useful features. Currently their design is an important challenge, one of the key issues being the integration of the pre-built components specific to different application domains (ex. electrical, mechanical, optical, etc.). In this context, new CAD tools offering the global view of the systems to be designed and enabling their overall validation are mandatory. This paper presents a generic discrete-continuous simulation model for an accurate global validation in component-based heterogeneous systems design. This model allows using powerful tools for the two domains; it was applied for simulation of systems integrating discrete models in SystemC and continuous models in Simulink. Its evaluation was performed using an illustrative application.


In this paper we form relations for the determination of the elements of the E\"otv\"os matrix of the Earth's normal gravity field. In addition a relation between the Gauss curvature of the normal equipotential surface and the Gauss curvature of the actual equipotential surface both passing through the point P is presented. For this purpose we use a global Cartesian system (X, Y, Z) and use the variables X, and Y to form a local parameterization a normal equipotential surface to describe its fundamental forms and the plumbline curvature. The first and second order partial derivatives of the normal potential can be determined from suitable matrix transformations between the global Cartesian coordinates and the ellipsoidal coordinates. Due to the symmetry of the field the directions of the local system (x, y, z) are principal directions hence the first two diagonal elements of the E\"otv\"os matrix with the measure of the normal gravity vector are sufficient to describe the Gauss curvature of the normal equipotential surface and this aspect gives us the opportunity to insert into the elements of the E\"otv\"os matrix the Gauss curvature.


Seven patients with primary non-Hodgkin lymphoma of the skeleton were examined with MRI. The results were compared to "small cell" primary malignant bone tumors. The latter showed marked hyperintensity on SE T2-weighted images; in contrast, the lymphomas appeared as inhomogeneous lesions of low signal intensity on T2-weighted images. Histologic examination with silver stains of specimens of these lesions revealed a high content of fibrous tissue, which could explain the signal behavior on MR. All seven lymphomas were located in the epiphysis or metaphysis of the appendicular skeleton; intraarticular tumor growth was demonstrated in five cases.


The basic characteristics of traditional industrialization process include: undue pursue of economic growth,malicious cycle of mass product and mass consumption,unrestrained abuse of resources and arbitrary damage to the environment.That is actually an abnormal and un-continueable development route,from which lessons must be learned in the process of today's industrialization of China.


The upgrading of ALPI has just been completed. All the 44 accelerating medium β cavities and two bunching resonators had their Pb coating replaced by sputtered Nb; further eight installed resonators, of high β type, are produced by the same technology. The refurbishing of the resonators allowed to increase their average accelerating field from 2.6 to more than 4.4 MV/m, at 7W dissipated power, in spite of geometry and copper quality problems in the existing substrates. Some resonators can reach and operate at more than 6 MV/m. The renewed cavities are driven by the same amplifiers and control systems of the previous Pb/Cu resonators and maintain the same reliability even when set at much higher accelerating fields. The low sensitivity of their resonant frequency to He bath pressure fluctuations allows their operation without necessity of any continuous tuning system. The upgrading of resonators, that was realized at a negligible cost and was combined to a necessary programme of cryostat maintenance, did not interfere with ALPI beam time schedule.


The word 'naturalism' has a bewildering array of uses in philosophy. Roughly speaking, it connotes pro-scientific attitudes and approaches. This article introduces the subject of naturalism by sketching a history of pro-scientific attitudes and approaches in philosophy, from their origins in the early modern period through to the present day. It then distinguishes a number of distinct families of naturalism: metaphysical, logico-linguistic, epistemological, and methodological. The resulting taxonomy encompasses a plurality of loosely related views rather than a number of variations on a single clear and unified theme.


Yan'an is located in Loess Plateau,and one of the most serious soil erosion areas in our country,and also the key areas needing vegetation construction.But the results of afforestation since the 1990s was not unsatisfactory.The results showed that there were space differenced of soil moisture and general soil-drying phenomenon,regardless our determination come from orchard field which were planted meticulously.The facts showed that soil-drying layer came from objective bases.According the soil moisture state of areas of Yan'an,rational artificial afforestation in the south of Yan'an and middle part could carry on,and northern territory should rely mainly on the grass vegetation,and topography broken area must be made horizontal steps,and collect water in the course of afforesting.


Agricultural industrialization base on agricultural standardization. The realization of agricultural products as commodity and marketability of agricultural products is the premise of the realization of agricultural industrialization. The two type of integration have different essence and different influence in agricultural industrialization.


As many as one out of three Americans uses alternative health therapies. The purpose of this study was to describe the type and frequency of alternative health care practices and sociodemographics of patients in nurse practitioner clinics in North Mississippi in order to determine implications for nurse practitioners. Leininger's Theory of Cultural Care Diversity and Universality served as the conceptual framework for this study. The researcher, using a descriptive study design, sought to answer the following questions: 1) What are the characteristics of patients who use alternative health care practices? 2) What types of alternative health care practices are being used by patients who attend nurse practitioner clinics? and 3) What is the frequency of alternative health care practices for patients who visit nurse practitioner clinics? A convenience sample of voluntary participants was identified in two nurse practitioner clinics. The sample consisted of 66 rural and 47 urban patients for a total of 113. Patients were surveyed


We present a constant amplitude multi-code CDMA scheme, which achieves an information rate of (314)/sup K/ for any K, while Wada's scheme is realizable only for 3/4 (K=1) and 9/16 (K=2). The proposed method has a recursive structure such that the input at the top-level encoder continues to be divided into three groups and lets the lower-level encoders handle the divided input. Finally, groups of three bits are separately encoded at the basic-level encoders and combined recursively to form a constant amplitude chip signal. Previous works such as Wada's scheme and Kim's scheme are analyzed in comparison.


Political actors use ICTs in a different manner and in different degrees when it comes to achieving a closer relationship between the public and politicians. Usually, political parties develop ICT strategies only for electoral campaigning and therefore restrain ICT usages to providing information and establishing a few channels of communication. By contrast, local governments make much more use of ICT tools for participatory and deliberative purposes. These differences in usages have not been well explained in the literature because of a lack of a comprehensive explanatory model. This chapter seeks to build the basis for this model, that is, to establish which factors affect and condition different political uses of ICTs and which principles underlie that behaviour. We consider that political actors are intentional and their behaviour is mediated by the political institutions and the socioeconomic context of the country. Also, though, the actor's own characteristics, such as the type and size of the organization or the model of e-democracy that the actor upholds, can have an influence in launching ICT initiatives for approaching the public.


The Piauí Formation records the deposition of aeolian, fluvial and shallow marine systems accumulated in a cratonic sag basin. Characterization of the facies associations and sequence stratigraphic framework was done by detailed description of sedimentary facies and logging of outcrops. The facies were classified based on grain texture (size and selection) and sedimentary structures observed. Paleocurrent orientations were measured from cross-strata. Stratigraphic sections were measured at a 1:50 scale at outcrops with good vertical exposure. Six facies associations were recognized: aeolian dunes and interdunes, aeolian sandsheets, fluvial channels, tidally-influenced fluvial channels, upper shoreface and lower shoreface. Through correlation of stratigraphic surfaces the facies associations were organized in system tracts, which formed eight high frequency depositional sequences, bounded by subaerial unconformities. These sequences are composed of a lowstand system tract (LST), that is aeolian-dominated or fluvial-dominated, a transgressive system tract (TST) that is formed by tidally-influenced fluvial channels and/or upper and lower shoreface deposits with retrogradational stacking, and a highstand system tract (HST), which is formed by lower and upper shoreface deposits with progradational stacking. Two low frequency cycles were determined by observing the stacking of the high frequency cycles. Both sequences are formed by an initial regression followed by a progressive transgression. The main control on sedimentation in Piauí Formation was glacioeustasy, which was responsible for the changes in relative sea level. Even though, climate changes were associated with glacioeustatic phases and influenced the aeolian and fluvial deposition.


It was a brave crew of muckrakers who followed John S. Phillips from the offices of McClure's to the American in 1906. The author, a University of North Carolina history professor, traces the melancholy story of the magazine's decline and its passing into the hands of owners who put profits first.


Mechanism of dissolution of calcium oxalate monohydrate (COM) crystals was studied in the absence and presence of Argnine (Arg), Aspartic acid (Asp), Alanine (Aln) and Asparagine (AS) at 37oC, I=0.15 mol dm and PH=6.5 from the study,it was obtained that concentrations as low as 10 mol dm for each additive markedly reduce the dissolution rate of COM crystals. As the concentration of additive increase, the active sites on COM crystal surface are blocked through adsorption and the rate of dissolution of crystals decreased. This confirmed from the order of reaction (n=2), the value of activation energy, 7.14 Kcal / mol, and the validity of applying Langmuirisotherm. The values of affinity constants in the presence of Arg, Asp, Aln and As are: 7.5,6.6,5.19 and 4.17 ×10 dm mol respectively. The values of affinity constants (Kl) reflect the high adsorption at the same value of relative degree of undersaturation (σ = 0.09), and the order of inhibition was: Arg >Asp > Aln > As. The values of ΔG supported this order of inhibition of these additives. From the study, the anionic part of the additive molecule adsorbs onto Ca active sites on the surface of COM crystals through electrostatic attraction. The molecular weight, molecular geometry, hydrophilicty and structure of the amino acid molecules were found to be the important factors affecting on the efficiency of the them. [N. S. Yehia, and D. I. Saleh. Influence of Some Amino Acids on the Mechanism of Dissolution of Calcium Oxalate Monohydrate Crystals. J Am Sci 2014;10(5):182-190]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 24


The positive rates of hepatitis B viral markers according to many epidemiologic factors were analyzed in 2,873 pregnant women who delivered at St. Columban's Hospital in Mokpo City from April 1st, 1985 to March 31st, 1986. The following results were obtained: The overall HBsAg positivity in all pregnant women was 8.3%. The positive rate of HBsAg was unrelated to age. It was 13.2% in the 11–20 year age group. 12.5% in the 31–40 year age group, 7.8% in the 21–30 year age group and 0.0% in the 41–50 year age group. The positive rate of HBsAg was slightly related to locality. It was a little higher in women who grew up in rural areas (8.6%) than in urban areas (7.7%). The positive rate of HBsAg was unrelated to educational background. The positive rate of HBsAg was unrelated to economic status. It was 8.7% in the highest income group and 8.6% in the lowest income group. The positive rate of HBsAg was higher in cases who had injections more than four times. The positive rate of HBsAg was higher, but not significantly, in cases who had received blood transfusion. The positive rate of HBsAg was higher, but not significantly, in cases who had more than three siblings (0.05 <p <0.1). There was no significant difference in HBsAg positivity if there had been a history of venereal disease. The effect of a family history of liver disease: The positive rate of HBsAg showed significant increase if there was a family history of liver disease (p<0.005). The positive rates of Anti-HBs, Anti-HBc, HBeAg and Anti-HBe were increased, but not significantly, in cases with a family history of liver disease. The effect of acupuncture. The positive rate of HBsAg showed a significant increase according to the freguency of acupuncture (0.025 <p <0.05). The positive rate of HBeAg was increased proportionately (0.05 <p <0.1), but the positive rates of Anti-HBs. Anti-HBc and Anti-HBe showed no difference according to the freguency of acupuncture. The positive rate of Anti-HBs was significantly higher in student nurses (48.6%) and graduate nurses (58.0%) than in female university students (27.7%) (p<0.005). The positive rate of Anti-HBc tended to be higher (0.05 <p <0.1). The positive rates of HBsAg. Anti-HBs and Anti-HBc didn't show any apparent tendency to increase in student and graduate nurses according to their year by year contact with patients.


Die-bonding technology using Cu sinter pastes is an attractive and important joint method for power devices operating at higher temperatures. This paper describes the effect of sintering temperatures on die-shear strengths of non-pressure sintered copper (sCu) onto six different metal platings (Cu, Ni, Electroless Ni, Pd, Ag, and Au). The die-shear strengths of sCu on the metal plating under sintering temperatures (225-350 °C) in H2 gas were measured. As the sintering temperatures increased, the shear strengths on the Cu, Ni, and ENi plating increased, whereas those on the Pd, Ag, and Au plating decreased. By analyzing the element distribution on the bonding interfaces using SEM/EDX, it was found that the self- and non-diffusion couples (sCu:Cu, sCu:Ni, sCu:ENi) can keep the high shear strengths and the diffused couples (sCu:Pd, sCu:Ag, sCu:Au) can deteriorate the shear strengths.


undreds of years ago, the tradition of experimenting on individual patients was carried out sporadically. There was very little distinction between experimentation and therapy as most therapies were experimental. Systematic evidence of the effectiveness of various treatment interventions was lacking. Experimental therapies were then tried to benefit ailing patients. Unfortunately at times such therapies led to worsening medical status. Most researchers were medical practitioners, who were motivated and trusted to do what they thought best for the patients. Fraud and abuse were minimized through peer censorship rather than reviewership. There was no specific code of ethics, laws, or regulations governing the conduct of scientific research. Early in the 19th century after the development of Penicillin by Alexander Fleming and other antibiotics, drugs were required to prove evidence of safety by law before being marketed. This stipulation has given immense attention to scientific research particularly from regulating bodies and pharmaceutical industry and also led to distinguishing the clinical practitioner from the clinical researcher. Generally, clinical practice refers to activities and interventions that are designed solely to enhance the well being of an individual patient and have a reasonable expectation of success. However, the goal of the research is to develop a general knowledge to better understand health and improve health care with similar disorders or risk profiles as well as for future patients and the society. 1 Therefore, clinical practice consists of activity to diagnose, prevent, treat or care for an illness or condition in a particular individual in order to benefit that individual whereas, clinical research is designed to answer a question and generate knowledge useful to others. Hence, it is paramount to distinguish between conducting biomedical and behavioral research on one hand and the practice of medicine on the other for several reasons. These relate to ethical, professional, financial and other issues that can generate potential conflicts of interest when physicians conduct research involving people, and particularly their own patients. Clinical


Household saving ensures a smooth future by softening the potential insecurities arise from uncertainty at the cost of present consumption. Moreover, the volume of national investment determines the actual health of an economy which is intensively associated with national savings. This study aimed at determining the effects of different socio-economic characteristics of rural households on their saving decision in Pabna district of Bangladesh. This research used a set of cross-sectional data from 250 households from three upazilas in Pabna district namely Pabna Sadar, Iswardi and Sujanagar on the relevant variables for the empirical analysis. A multistage random sampling technique involving simple, purposive and stratified random sampling was used to draw the sample. The study employed a binary logistic regression model to assess the influences of different socio-economic and demographic characteristics of rural household on their saving decision. The findings of the current study asserted that gender, family size and dependency ratio of household have significant and negative effects on their decision to start saving or not to start saving. Contrarily, the effects of the variables age, education level, marital status, income, secondary earner and liabilities on the decision of households to participate in saving were positive Original Research Article Al-Amin; AJEBA, 20(2): 14-20, 2020; Article no.AJEBA.62892 15 and significant. Moreover, the results revealed that social status has a strong but insignificant effect, but the variables access to bank and credit facilities have almost no significant effect on the household saving decisions. Since, private savings is essential for both the micro and macro level of an economy, therefore the study tried to suggest some recommendations with a view to increase private savings.


In January of 1941, Henri de Lubac delivered two lectures on the theme of "The Theological Foundations of the Missions."1 These lectures are noteworthy for several reasons. First, it is helpful to recall the setting: early 1941 was a dark and difficult time for the Catholic faithful in France. Their country had fallen to Nazi Germany, and the seductive poison of Nazi ideology was making inroads in the Church. More than a few members of the Church were ready to collaborate with the Vichy regime. Together with


Effective strategic planning is crucial for FET colleges. This is more so considering that the colleges are operating in complex and turbulent world of vocational education. This article provides a summary of the results of an empirical survey which was conducted to explore irregularity of strategic management of FET colleges in South Africa. The paper reveals the strategic planning, strategic implementation, and strategic monitoring, evaluation and control processes. The research focused on the involvement of internal and external stakeholders into strategic management at FET colleges. The findings showed that there were success and failure factors of strategic management in public colleges of South Africa. The research results further provided insights into future changes in the area of public college strategic management.


The political and social instability in many parts of the world has led to large numbers of refugees forced to find a haven in Europe. Both social and political pressure is felt in these host countries as they see the resulting situation worsening dramatically. In this article, an analysis of the geo-sociological assumptions within the conventional conception of social inclusion is undertaken. As a result, an alternative is presented based upon the knowledge-based, network-oriented nature of modern European society. This is referred to as Virtual Social Inclusion and it aims primarily at two fundamental dimensions of human activity: education and employment. The article focuses on the nature and implications of VSI for inclusive education and its underlying principles, particularly mobility and openness. It also details the educational framework needed, and what VSI requires to turn from a theoretical framework into a practical reality and the foreseeable implications of its implementation are explored.


There has been a surge in the number of employed people looking for another job in Britain in the last twenty years. In this paper we present the first time series analysis of on-the-job search. Vacancies are a significant explanatory variable in equation but unemployment is not. We interpret this as evidence that the unemployed do not effectively compete with employed job searchers in the labour market.


study of the prophet Shu'ayb (V, pp. 425-40), as seen by Ibn Taymiyyah, and the catalogue raisonne" of Islamic and non-Islamic sects (VII, pp. 85-95) are important reading for any Islamist. The sheer density of detail in all these studies is impressive. In a number of these studies Bosworth raises a list of questions which call for an answer. For example in "Jewish elements in the Banu Sasan", a paper originally prepared for the International Conference on Jewish Communities in Muslim Lands, Jerusalem, 1974, he begins "The classical Arabic literature of the medieval Islamic period is essentially one of the aristocracy of letters and of social studies, and outside popular stories of the Thousand and One Nights type and the epic romances, and also the proverbs, we have comparatively little reflecting the social and cultural life of the lower classes". I suspect that this material is far less rare than we think. Since much of it must have been oral, then is it not likely that a great deal of the "oral literature" of bard, story-teller, peasant, and nomad, in fact incorporates much of this "lost" literature, and that what can be heard and collected, even today, accurately reflects this type of literature in the medieval period? Orientalists have fought shy of examining this "literature" and have dismissed it as worthless or as unpublishable because so often it is frankly "pornographic", at best vulgar, crude, ungrammatical, and hence worthless. But it is the Orientalist that has decided that this is so, not that the literature is non-existent. A careful search through the Oriental libraries of Western Europe I can think of several examples in Scandinavia — will reveal a collectio narrationum lepidarum which is far from worthless and never dull, though admittedly unpublishable in many instances; and this if studied would throw a great deal of light "on the demi monde of beggars, rogues, tricksters and petty criminials". On another, and very different, topic, the terminology of the history of the Arabs in the Jahiliyyah according to Khwarazmi's "Keys of the sciences" (X, pp. 27—43), Bosworth's translation offers valuable comments on a number of familiar terms, the Ahdbish, the Aqydl, the Adhwa', and the MakhdUf to name but a few. The first, al-Khwarazmi tells us, "acquired this name because they came together (Ji-tahabbushihini), that is, gathered together with the idea of forming a covenant". This is categoric enough, yet it is perhaps premature to dismiss the views of Lammens as "extravagant theories" (pp. 37-8). This publication is admirably printed. The accuracy of transcription is very impressive. An appendix by Dr. James Dickie on the tomb of 'Umar ibn 'Abd al-'Aziz, together with photograph, is included. The genealogies are useful and index comprehensive, although it is unfortunate that there is an error of pagination between pp. 6 and 7, letters Q to S having been printed on p. 3. An errata slip might be useful. This is a worthy contribution to a valuable series of books.


Abstract : Pressure pulses caused by irradiation of a model gallium arsenide solar cell with a Carbon Dioxide TEA Laser were examined using power densities of the order of 10 to the 7th power watts/sq cm. The pressure pulses were monitored with a Sandia type quartz pressure gauge. It was discovered that the relatively low power densities used were capable of removing the silicon dioxide antireflective and gold contact layers of the solar cell after only a few shots of the laser. An exponential relationship between the initial thicknesses of these layers and the pressure pulse generated in the gallium arsenide substrate was indicated for gold contact layers of less than 5000 A thickness. Evidence was found that the principal pressure generation mechanism is thermo-mechanical. Gold films of thickness greater than 5000 A were found to be able to absorb the power densities used with no apparent damage. (Author)


Separate adults and children graveyards have been encountered in the modern Turkey as in Şanliurfa. This study aims to analyze possible reasons of segregation of graves for sub-adults and establishing separate graveyards both for adults and sub-adults. It is proposed that the roots of this difference can be found in the definition of human development. Perceiving infants and children as "incomplete humans" might be the main reason of keeping them apart from the domain of cultural beings. Differences in grave places of infants and adults might be related to their bio-cultural development, their being considered as "person" or "non-person."


Little research exists concerning substitute teachers, with the result that they are frequently employed and assigned on the basis of mere guess- work. Some con siderations and some approaches that would allow school systems to upgrade the use of substitutes are offered here.


This study was carried out to examine the extent of the implementation of the Integrated Islamic Education system and its enhancement on teaching and learning through technology. This study is a qualitative research into the implementation of educational technology in the teaching and learning processes of Integrated Islamic Education in Brunei Darussalam. The Pioneer Schools (Sekolah Rintis) and the Thoughtful School (Sekolah Hatiminda) are solid evidence that Brunei has decided to settle on the Integrated Islamic Education for its future generations. The analysis of the interviews and questionnaires conducted concluded that Educational Technology was already being utilized to some extent in the classroom. However, they did not realize that they have been using and applying Educational Technology daily. The teachers need to make the teaching and leraning process effective and interesting. The Educational Technology practiced in primary schools is slightly limited in the areas of application of teaching methodology and approach, application of media in teaching and management and administration of the research schools.


This paper presents an hybrid algorithm based on genetic algorithm and ant colony optimization for continuous optimization, which combines the global exploration ability of the former with the local exploiting ability of the later. The proposed algorithm is evaluated on several benchmark functions. The simulation results show that the proposed algorithm performs quite well and outperforms classical ant colony optimization and genetic algorithm for continuous optimization, which efficiently balances two contradictory aspects of its performance: exploration and exploitation. Keywords-component; hybird; GA; ACO; continuous Optimization


The sludge in tanks 42 and 51 is to be washed with inhibited water to remove soluble salts and combined in tank 51 in preparation for feed to DWPF. Since these tanks contain uranium and plutonium, the process of washing must be evaluated to ensure subcriticality is maintained. When the sludge is washed, inhibited water is added, the tank contents are slurried and allowed to settle. The sludge wash water is then decanted to the evaporator feed tank where it is fed to the evaporator to reduce the volume. The resulting evaporator concentrate is sent to a salt tank where it cools and forms crystallized salt cake. This salt cake will later be dissolved, processed in ITP and sent to Z-Area. This report evaluates the supernate and sludge during washing, the impact on the evaporator during concentration of decanted wash water, and the salt tank where the concentrated supernate is deposited. The conclusions generated in this report are specific to the sludge currently contained in tanks 42 and 51.


A renewable energy system discussed in this paper is a stand-alone wind-hydrogen system for a remote island in Australia. The analysis of an existing wind-diesel power system was performed. Simulation technique was used to model the power system currently employed on the island, and simulated different configurations of additional hydrogen energy system. This study aims to determine the suitable hydrogen integrated configuration to setting up the prototype system for the island, which helps to reduce the diesel consumption on the island. A set of configurations for the hydrogen system and associated parameters that consists of wind turbines, electrolysers, hydrogen internal combustion engines, and storage tanks has been purposed. The simulation analyses various configurations that perfectly balances the system to meet the demand on the island. Keywords—Hydrogen power systems, hydrogen internal combustion engine, modeling and simulation of hydrogen power systems.


Abstract Between March 1997 and September 2000, 3 species of owls (Bubo virginianus, Strix varia, Megascops asio), 4 species of hawks (Buteo jamaicensis, Buteo platypterus, Accipiter cooperii, Accipiter striatus), and 1 species of falcon (Falco sparverius) from Connecticut, U.S.A. were examined for gastrointestinal parasites. Eighteen species of helminths (10 trematodes, 1 cestode, 6 nematodes, and 1 acanthocephalan) were collected for the first time from the northeastern United States in general and Connecticut and New England in particular. The trematodes Ophiosoma microcephalum from B. jamaicensis and Neodiplostomum accipitris from A. striatus represent new host records. The trematode Microparyphium facetum collected from B. virginianus represents the first report of this helminth from a North American owl. The tapeworm Paruterina rauschi is reported for the first time from S. varia. The nematode Baruscapillaria falconis is reported for the first time from M. asio, A. cooperi, and A. striatus. The acanthocephalan Centrorhynchus kuntzi is reported for the first time from A. cooperi. One species of trematode (Neodiplostomum americanum) and 2 species of nematodes (Baruscapillaria falconis, Porrocaecum depressum) were shared between species of owls and hawks.


This article introduced the basic principle and the calculate process of the on-line detection system for centrifugal-pump running parameters,and the method of curve fitting of Q—H、Q—N performance curves of centrifugal-pump.The analysis of experiment indicated that the studied system had high precision,which could on-line display the running parameters of the centrifugal-pump,such as flow,height,shaft power and efficiency.This on-line detection system could meet practical application of commonly water pumping station project.


The European standard EN ISO 140-12:2000 gives a methodology to measure the acoustic performance of access floors in terms of both airborne and impact sound insulation. Access floors are often used in office buildings and working environments as they create a hollow space below the floor surface for network cabling and electrical wiring: in this way they are useful from the functional (ease of inspection, repair and changing of system elements), the aesthetic (no exposed wires and elements) and acoustic point of view. This paper presents the measurement procedures used at the Acoustic Laboratory of the University of Perugia – Italy, in order to perform the tests defined by the EN ISO 140-12. The standard requires the measurement of two parameters, Ln,f e Dn,f , that qualify respectively the airborne and the impact sound insulation trough an access floor, and the calculation of the two corresponding single number indexes Ln,f,W e Dn,f,W. A sample of access floor has been tested in the purposely prepared reverberating rooms of the Laboratory, with and without covering. Particular attention has been paid to test rooms set up and to sample installation because of the complexity of these phases. INTRODUCTION An access floor is a raised floor system consisting of modular panels supported by steel posts, placed at a certain height to create a gap below the floor surface. This hollow space can be efficiently used for data transmission, automation, processing, telephone network cabling and electrical wiring, avoiding unattractive exposed installations and offering great flexibility for operations involving the inspection, repair, changing or adding of system elements. Moreover a wide range of finishes can be applied over the panels (tiles, carpet, parquet, lino, etc...). For these reasons access floors are becoming widely used especially in the building of office centres and working environments. A measurement methodology and a test facility were set up for this purpose at the Acoustic Laboratory of the University of Perugia in order to evaluate the acoustical properties of access floors following the procedures given by the European Standard EN ISO 140-12 [1]. This standard requires the measurement of the two parameters Ln,f e Dn,f, defined as the normalized lateral impact sound pressure level and the normalized lateral airborne sound insulation; the corresponding single number ratings Ln,f,W e Dn,f,W are then calculated by means of the EN ISO 717-1 e 2 standards [2], [3]. These two quantities allow to qualify the acoustical performance of the floor as far as the airborne and the impact noise; more precisely, they define the efficiency of the floor in stopping the propagation of noise between two adjacent rooms having the same access floor and divided by a wall that is usually more insulating than the floor (Figure 1). Separating walls are indeed commonly installed directly over the raised floor, so creating an easy path for sound through the gap placed below the floor surface that links without obstacles the two rooms. Hence inadequate structures or materials and uncorrected designing can cause conditions of high acoustical discomfort.


To the Editor.— The severely sprained ankle has always been a problem. Elastic bandage, cold compresses, and crutches have been the methods of choice of most emergency rooms. Rehabilitation by this method is slow, discouraging and costly. The typical sprained ankle shows a painful and red egg-like swelling just below the lateral, (or occasionally the internal) condyle of the ankle, along with extreme tenderness and pain. It is generally the calcaneo fibular ligament which is broken (Fig 1). This area must be supported immediately, not with an elastic bandage, but with a plaster splint support (Fig 2). This support can be applied in an emergency room or a doctor's office. More extensive sprains would naturally receive more extensive splinting usually at the hands of an orthopedic surgeon. On some occasions, the internal ligaments are torn and of course, the findings and treatment require a like support, but on the opposite


Consumer Electronic Products are deemed essential in the new normal. Even with the increasing popularity of online marketplaces in the country, Filipinos are meticulous or careless in choosing a product. This pandemic has changed consumer behavior factors over the long term for further research - that is why this study aims to describe and identify the most influential purchasing behaviors of electronic products on Shopee and Lazada. Further understanding how the generations differ from each other's purchasing behavior; Knowing also the preferred online marketplace by Filipinos. The researchers conducted a quantitative descriptive-comparative study to achieve the objectives and gather data through an online survey. From the results, Filipino consumers' most influential purchasing behavior is the Product-Related Details. Filipinos wanted to physically assess the electronic product but with the restrictions of buying the product online. It is hard to base on all the product information, reviews, and feedback from other buyers.


The authors introduce a system of greenhouse measuring-controlling based on CAN-bus and MCU. By this paper, the authors analyzes the software and hardware design of this system, give the circuit diagram of the CAN-bus intelligent node and choose a interface board which connect PC and CAN-bus. The authors design the software system by keil C51, ASM and Visual C++6.0, the introduction of software and the software flow chat are given. Compare with the system based on RS-485 bus, this measuring-controlling system based on CAN-bus has a good stability, communication quantity and has a fit price.


OMNeT++ is a discrete event simulation environment primarily designed for communication networks. In this paper we present an approach to enable OMNeT++ to simulate complex hierarchical process chains. Process chains are a common modeling paradigm in the logistics area for analysis and optimization, and have been used intensely in many practical applications. Their evaluation is supported by the ProC/B toolset, a collection of software tools for modeling, analysis, validation and optimization of process chains. Here we describe how OMNeT++ has been integrated as a new simulation engine into the toolset. The integration has to overcome some core problems to allow a smooth interaction between OMNeT++ and the other tools: in particular, the OMNeT++ model description of the logistics network should be kept manageable, it should reflect the entire model structure and non-standard performance figures, being relevant for an economic evaluation should be ascertainable in order to satisfy the specific needs of the application area. This paper highlights the main steps of the automatic transformation of a hierarchical process chain model into a hierarchical model in OMNeT++. Furthermore, we show how the transformation has been validated and how detailed performance figures can be evaluated with OMNeT++.


The dynamic analyses are of key importance in the cognitive process in terms of the correct operation of structures loaded with time alternating forces. The development of vehicle industry, which directly results in an increase in the speed of moving vehicles, forces the design of engineering structures that ensure their safe use. The authors of the paper verified the influence of speed and vehicle parameters such as mass, width of track of wheels and their number on the values of displacements and accelerations of selected bridge elements. The problem was treated as the case study, because the analyses were made for one bridge and the passage of three types of locomotives. The response of the structure depends on the technological solutions adopted in the bridge, its technical condition, as well as the quotient of the length of the object and vehicle. A new bridge structure was analyzed and dynamic tests were carried out for trainsets consisting of one and two locomotives. During the actual dynamic tests, the structure was loaded with a locomotive moving at a maximum speed of 160 km/h.


Abstract A solid state oxalate sensor is reported utilizing a commercial ion-selective electrode, the SelectrodeTM. Comparative measurements in aqueous solution of similar carboxylate ions and common inorganic anions, indicates appreciabl'e selectivity for oxalate. The SelectrodeTM was activated with a mixture of silver sulphide, lead sulphide, and lead oxalate.


The invention discloses a blueberry seedling culturing method which mainly comprises the steps of: tissue culture and propagation expanding, indoor rooting, in-shed growing, and large-field seedling hardening. Through preparing two different culture mediums which are a WPM (Woody Plant Medium) normal culture medium and a hormone culture medium, a large quantity of blueberry seedlings are rapidly obtained under the condition of lower cardinal number of the seedlings, the propagation coefficient is high and the seedling culturing time consumption is reduced. By using the blueberry seedling culturing method provided by the invention, the propagation time of the blueberry seedlings is shortened by more than half a year in comparison with the same term in China; and meanwhile, due to the adoption of a plant tissue culture technology, the high purity of seedlings and the excellent root system are ensured, the plants grow very well after being planted, the fruit rate is increased by more than 10 percent in comparison with that of cut blueberry seedlings, the blueberry tissue culture rapid propagation process and the industrialized seedling production system in China can be improved, and the industrial seedling production and the commercial building of blueberry are sped up.


Aim: This study includes a comparative evaluation of the various surface treatments of the intaglio surface of crowns in combination with various luting agents for maximal retention. Materials and Methods: Totally, 150 dies of a standard complete crown preparation were fabricated. Wax pattern with a loop on the occlusal surface was prepared on each die using standard procedures, and then crowns were cast with nickel-chromium alloy. These crowns were randomly divided into five groups as per the surface of the intaglio surface of the metal copings. The crowns in each group were again subdivided randomly into three groups as per the luting agents used resin-modified glass ionomer cement, glass ionomer cement, and zinc phosphate cement. Retention was measured (MPa) by separating the metal crowns from the metallic die under tension on a Universal testing machine. Statistical Analysis Used: The data were recorded and statistically analyzed using one-way analysis of variance followed by Tukey's test. Results: The retention differed both with surface treatment and type of luting agents. Untreated group showed the least bond strengths < sandblasting with 50 µm alumina < sandblasting with 50 µm alumina with ultrasonic cleaning < sandblasting with 110 µm alumina < sandblasting with 110 µm alumina along with ultrasonic cleaning. For luting agents, glass ionomer cement showed least bond strength because there was no chemical bonding present between metal crown and metallic die, followed by zinc phosphate cement and maximum bond strength were found for resin-modified glass ionomer cement. Conclusion: Among all types of surface treatments used in this study, maximum bond strength was yielded by sandblasting with 110 µm alumina + ultrasonic cleaning and the best luting agent was resin-modified glass ionomer cement.


We investigate the automatic detection of sentences containing linguistic hedges using corpus statistics and syntactic patterns. We take Wikipedia as an already annotated corpus using its tagged weasel words which mark sentences and phrases as non-factual. We evaluate the quality of Wikipedia as training data for hedge detection, as well as shallow linguistic features.


The second national land survey is a strong professional and highly policy-oriented social systems engineering.The nationwide investigation of the land ownership and signing proprietorship protocol were one of the important works for the Second Land Survey.However,the establishment of proprietorship protocol required much workload and enormous human cost.At present,the automatic process of the ownership results by the computer did not achieved.MapGis was used to handle the results of ownership agreement,which could promote the work efficiency.


To improve the high-rate charge-discharge capability of Ni/MH power batteries,the nickel foam electrodeposited Co-Ce alloy with spicular structure and high specific surface was used as the substrate of nickel electrode,the content of Ce was 0.19%. The results showed that the average charge acceptance capability increased 36% and the average discharge specific capacity (increased) 42% at 10 C within 600 cycles. According to the XRD analysis, the CoOOH formed on the surface of Co-Ce alloy substrate of nickel electrode was the main factor in the improvement of electronic conductivity between the substrate and active material.


Implication for health policy/practice/research/medical education: Maintenance hemodialysis (MHD) could be a risk factor for COVID-19 prognosis partly due to the drug regimen of the patients. In our 90 MHD patients infected with COVID-19 who were treated with seven different drug regimens, we found patients expired due to COVID-19 had a significantly higher chance of needing oxygen therapy, mechanical ventilation, and intensive care unit admission compared to the survived patients. L. COVID-19 in patients under maintenance hemodialysis; clinical characteristics, laboratory findings and treatments. the various aspects of COVID-19 in Objectives: The present study aimed to identify the risk factors associated with higher COVID-19-related mortality in patients under MHD. Patients and Methods: The present retrospective study included 90 patients under MHD who were hospitalized with COVID-19 and diagnosed using the reverse transcription polymerase chain reaction (RT-PCR) from March 20, 2020, to December 20, 2020. Results: The participants' mean age was 57.5±18.61 years, and 49 patients (54.4%) were men. 35 patients (38.9%) were expired due to COVID-19. The most common underlying diseases included mellitus, hypertension The patients due to COVID-19 had a significantly higher chance of oxygen mechanical ventilation, and intensive care unit admission compared to survived patients. a significant negative relationship between mineral-multivitamin supplementation and COVID-19-related mortality was detected. of was significantly higher in the establish strict preventive measures. ABSTRACT


The case study method can be applied in public and professional course of law.Due to difference goals of these courses,the case study method should be used differently in selecting case and practice.Only when the teacher uses modern instruction facilities the case can exert its better function.


This article formulates the main problems of development and implementation of highly automated and autonomous vehicles in the road transport infrastructure. Perspective approaches to ensure security are considered and the advantages of their application are substantiated. A scheme has been developed for predicting and ensuring a given level of safety for highly automated vehicles. The advantages and prospects of using virtual tests both at the development stage and throughout the life cycle of highly automated and autonomous vehicles are substantiated in order to monitor their safety. Siemens Prescan software is given as a test simulation tool, its functions are considered. In addition, companion programs are described that can be collectively used to monitor the safety of highly automated vehicles, autonomous vehicles in service using virtual testing.


1. Introduction: Dilemmas of Ethical Organizing (Christina Garsten and Tor Hernes) 2. Risk, Responsibility and Conscience (Tore Bakken) 3. White as Snow or Milk? (Tor Hernes, Gerhard E. Schjelderup and Anne Live Vaagaasar) 4. Does Rule-Based Moral Management Work?: A Case Study in Sexual Harassment (Steve McKenna) 5. Challenges to Leader Integrity (Steven L. Grover and Robert Moorman) 6. Transparency Tricks (Christina Garsten and Monica Lindh de Montoya) 7. The Power of Activism (Debora L. Spar and Lane T. La Mure) 8. Thoughts and Second Thoughts About Enron Ethics (Ronald R. Sims and Johannes Brinkmann) 9. No Smoke Without Fire? (Todd Bridgman) 10. Overmanagement and the Problem of Moral Consciousness (Herve Laroche) 11. Tying Some Ends Together (Christina Garsten and Tor Hernes)


The surging design productivity of modern consumer electronics (CE) devices has only been possible due to the employment of reusable intellectual property (IP) cores in its hardware design. However, the IP core design process is vulnerable to threats in the design flow such as reverse-engineering attacks that aim to clone (and pirate) or insert malicious Trojan logic in the design netlist. Thus, the key is protecting the IP design netlist from unwanted access. This article proposes an IP core with a low-cost functional locking methodology that safeguards the design netlist from rogue elements in design flow intending attacks. The presented approach achieves cost reduction of functionally locked IP core design and enhanced security against reverse-engineering attacks.


Responsible management of global hospitality companies increasingly recognizes how important are concerns about the society, the environment as well as all stakeholders in maintaining a good market position. In Serbia, the concept of corporate social responsibility is relatively unknown and insufficiently researched in all business areas, especially in the hospitality industry where small businesses are dominated. The papers task is to present particular activities that demonstrate social responsibility to employees, customers-guests, local communities as well as the environment. The paper aims to highlight the benefits of adopting the principles of corporate social responsibility and innovation applied in catering enterprises as an example of good corporate social responsibility practices.


Green lacewings of the economically important genus Chrysoperla produce vibratory signals with their abdomens during courtship and mating. These signals or "songs" are complex and species-specific, and must be exchanged in a reciprocal manner between the male and female of a courting pair before copulation will take place. Such a system of communication could have evolved in response to sexual selection, selection from species isolation, or both. Sexual selection requires reasonably high variance among individuals in reproductive success, manifested as a polygamous mating system. The sympatric sibling species Ch. plorabunda and Ch. downesi, taken as representative of the genus, exhibit relatively low polygamy of females but extreme polygamy of males. However, because of irreversible sperm depletion in males, effective lifetime ability to produce offspring is approximately the same in both males and females, resulting in relatively low variance in reproductive success regardless of sex. Consequently, sexual selection alone is probably insufficient to account for the evolution and differentiation of the observed songs. On the other hand, experiments testing choice by females of conspecific versus heterospecific songs and courtship partners demonstrate clearly that calls are of the utmost importance in the reproductive isolation of closely related, potentially interfertile species. Other laboratory studies reveal that the basis for call differences between species like Ch. plorabunda and Ch. downesi is polygenic yet still simple, indicating that complete reproductive isolation and hence specification in the genus need not involve much genetic change. Thus it is not entirely unexpected that in certain regions, such as the mountains of western North America and central Europe, exist several physically indistinguishable but acoustically unique "song morphs" of the carnea-plorabunda-downesi complex that seem to be reproductively isolated from their often sympatric relatives only by their calling behavior. I suggest here that small, chance alteration in the genes controlling call patterns can catalyze specification in such lacewings by preventing normal individuals from dueting and copulating with mutants. Sexual selection probably facilitates the process of divergence by assuring that individuals prefer partners with extreme and therefore more attractive calls. Thus, species proliferation within the complex can occur without obvious adaptive or historical cause.


In this paper, we discuss the all-fiber approach to current sensing for high voltage applications. We present different sensors, based on the Faraday effect, which allow to perform measurements without any contact or linkage between the fiber and the line. This is obtained by an accurate control of the bending birefringence in the sensing coil and by a proper design of its shape. Using a multimode laser diode and a polarization readout scheme,the typical sensitivity is 1A (rms), with a dynamic range up to three decades and a bandwidth of 10 KHz. These performances are adequate both for steady-state measurement and transient monitoring.


Background . The majority of hematopoietic stem cell (HSC) transplants are performed using peripheral blood mobilized with granulocyte-colony stimulating factor (G-CSF) given over 5 days. The goal of a successful transplant is to reliably mobilize optimal numbers of HSCs necessary for rapid and consistent multilineage engraftment. Infusion of mobilized allogeneic grafts results in significant acute and chronic graft-versus-host disease (GvHD) in up to 80% of allogeneic transplant recipients. A reliable and rapid method to mobilize HSC-rich grafts with reduced GvHD potential would be clinically meaningful.
 In a Phase 1 study of normal volunteers, MGTA-145 (GroβT), a CXCR2 agonist, when combined with plerixafor, a CXCR4 inhibitor, robustly and rapidly mobilized sufficient HSCs for a safe transplant after only a single day of dosing and apheresis/collection. Here, we phenotypically and functionally profile these mobilized grafts obtained from human volunteers and show that MGTA-145 + plerixafor mobilizes grafts with >10-fold higher engraftment potential (as measured by SCID-repopulating units in NSG mice), a marked reduction in xenogeneic GvHD, and enhanced overall survival compared to G-CSF or plerixafor alone grafts.
 Results . In healthy donors, a peak of 40 CD34+ cells/μL were mobilized with MGTA-145 + plerixafor (n=12 donors). 11 of 12 (92%) of these donors mobilized >20 CD34+ cells/μL with single day dosing compared to only 8 of 14 (57%) achieving the same CD34+ cell target treated with plerixafor alone. Eight donors were mobilized with a single dose of MGTA-145 + plerixafor and apheresed on the same day. A median of 4x106 (1.5-7.0x106) CD34+ cells/kg were obtained (n=8 donors) from a median 20 (13-20) L collection. 35.8 (18.5-40.9)% of these cells were CD90+CD45RA-, a CD34+ subset enriched for HSCs, compared to only 6.9 (5.3-9.0)% with G-CSF (p<0.001, n=3 donors). Mechanistically, MGTA-145 bound to CXCR2 on neutrophils and led to a modest and transient increase in plasma concentrations of matrix metalloproteinase 9 (MMP- 9), a downstream target on neutrophils.
 To assess engraftment, we transplanted mobilized peripheral blood cells from healthy donors after a 5-day regimen of G-CSF or a single dose of plerixafor alone or MGTA-145 + plerixafor at limit dilution into sublethally irradiated primary and secondary NSG mouse recipients (n=3 cell doses, n=7-8 mice/group). Multilineage human engraftment was measured by flow cytometry 16 weeks post-transplant and SCID-repopulating cell (SRC) number was calculated (Figure 1A). MGTA-145 + plerixafor mobilized grafts (n=4 donors) led to a 23-fold increase in engraftment compared to G-CSF mobilized grafts (p<0.001, n=3 donors) and 11-fold higher engraftment compared to plerixafor mobilized grafts (p<0.001, n=3 donors).
 Immune cell subsets (B, T, and NK cells and cell subsets) mobilized by MGTA-145 + plerixafor were similar to those mobilized by plerixafor alone. While CD3+ T-cell numbers were comparable between MGTA-145 + plerixafor and plerixafor alone, MGTA-145 + plerixafor mobilized 0.2 (0.0-0.6) x108/kg CD8+ T-cells, constituting 1.8 (0.5-4.8)% of the graft, a number and proportion significantly lower than that mobilized by either G-CSF or plerixafor alone.
 To determine the effect of the mobilization regimen on xenogeneic GvHD, we developed a xenograft GvHD model in NSG mice where 6x106 PBMCs from various graft sources were infused into sublethally-irradiated animals (n=3-6 donors per graft source). Notably, MGTA-145 + plerixafor mobilized grafts resulted in significantly less GvHD than G-CSF (p<0.01) or plerixafor (p<0.001) grafts (Figure 1B). In vivo cellular subset depletion studies suggested that the GvHD protective effect in MGTA-145 + plerixafor grafts may be in part due to immunosuppressive monocytes which were not present, or present to a lesser degree, in grafts from donors mobilized with G-CSF or plerixafor.
 Conclusions . These data demonstrate that MGTA-145 + plerixafor is a rapid, reliable, and G-CSF free method to obtain high numbers of HSCs with durable engraftment potential and a graft with highly immunosuppressive properties. These data suggest that MGTA-145 + plerixafor is an effective single-day mobilization/collection regimen for both autologous and allogeneic stem cell transplantation resulting in enhanced engraftment and reduced GvHD in this xenograft model.

 Goncalves: Magenta Therapeutics: Current Employment, Current equity holder in publicly-traded company, Patents & Royalties. Hyzy:Magenta Therapeutics: Current Employment, Current equity holder in publicly-traded company. Hammond:Magenta Therapeutics: Current Employment, Current equity holder in publicly-traded company. Falahee:Magenta Therapeutics: Current Employment, Current equity holder in publicly-traded company. Howell:Magenta Therapeutics: Current Employment, Current equity holder in publicly-traded company. Pinkas:Magenta Therapeutics: Current Employment, Current equity holder in publicly-traded company. Schmelmer:Magenta Therapeutics: Current Employment, Current equity holder in publicly-traded company. Hoggatt:Magenta Therapeutics: Consultancy, Current equity holder in publicly-traded company. Scadden:Magenta Therapeutics: Consultancy, Current equity holder in publicly-traded company, Membership on an entity's Board of Directors or advisory committees. Devine:Magenta Therapeutics: Consultancy. DiPersio:Magenta Therapeutics: Membership on an entity's Board of Directors or advisory committees. Savage:Magenta Therapeutics: Current Employment, Current equity holder in publicly-traded company. Davis:Magenta Therapeutics: Current Employment, Current equity holder in publicly-traded company.


Ultrafast angle-resolved XUV photoemission reveals the timeand momentum-dependent electronic structure of 1T–TaS2, a hybrid Mott and chargedensity-wave insulator. Both electronic orderings melt well before the lattice responds, suggesting that electronic correlations play a role not just in the Mott localization but in the CDW ordering as well.


Gas transfer velocities of SF 6 and 3 He were determined in a Kerguelen Islands lake at wind speeds in the range 0-10 m/s by injecting the two tracers into the water and measuring their concentrations over 40 days. Two methods are investigated for the determination of the relationship linking the gas transfer velocity K to the wind speed W. The first method postulates a power law relationship K=βW α This leads to the same exponent α=1.5±0.2 for both gases. The second method is the classic determination of the gas transfer velocity K ij between two tracer measurements at times t i and t j using the well-mixed reservoir assumption. This method proves to be less favorable owing to its nonlinearity bias and also because it induces much scatter in the gas transfer coefficient/wind speed relationship. This dispersion is shown to anse from the experimental scatter of the data and, above all, from the high sensitivity of the method to even small heterogeneities in the tracer vertical distribution. In the present experiment, the Liss and Merlivat correlation [Liss and Merlivat, 1986] is shown to underestimate the actual mean gas exchange rate by about 40%. Our results agree with the recent dual-tracer experiment by Wanninkhof et al. [1993] and are also consistent with CO 2 transfer coefficient data derived from the study of 14 C oceanic inventories. As expected from gas transfer theories and various experimental observations, the Schmidt number exponent in the comparison of 3 He and SF 6 transfer velocities is found to vary substantially with the transfer regime. However, its variation is found to be greater than that forecast by current gas transfer models, with values as high as n=-0.2 for intermediate to strong winds. This again raises the question of the validity of the normalization method for K CO2 calculation from gas transfer experiments, especially in high-wind regimes.


The multiparametric min max 0-1-Integer Programming (0-1-IP) problem relative to the objective function is a family of min max 0-1-IP problems which are related by having identical constraint matrix and right-hand-side vector. In this paper we present an algorithm to perform a complete multiparametric analysis relative to the objective function.


The invention discloses a mounting structure of an automobile towing hook cover plate and a fender guard. The mounting structure comprises the towing hook cover plate and the fender guard, wherein the towing hook cover plate is clamped on the fender guard by a buckle and a clamping bolt arranged on an inner surface; the inner surface of the towing hook cover plate is provided with two bosses; the two bosses are symmetrically arranged relatively to a connecting line between the buckle and the clamping bolt; the surface of the fender guard, which contacts the inner surface of the towing hook cover plate, is provided with two grooves; and the two bosses are respectively positioned in two grooves to form a rotation pair. According to the mounting structure, the towing hook cover plate can be opened without any tools and operation is convenient and simple.


An association has been found between the presence of lipid‐specific oligoclonal IgM bands (LS‐OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course.