The paper describes the propagation of surface waves localized near the edge of a plate (edge waves). Antisymmetric waves are considered in a plate with fixed faces. Three-dimensional theory of elasticity is used to study higher order edge waves. Asymptotic analysis is performed, which shows that there is an infinite spectrum of higher order edge waves. Asymptotics of phase velocities are obtained for the large values of the wave number. It is demonstrated that in the short-wave limit the phase velocities of all higher order edge waves tend to the velocity of Rayleigh wave. Numerical investigations are performed by using the modal expansion method. Numerical results are presented for the first four higher order edge waves . All these waves except the first one are damped by propagating modes, but for each wave there is a critical wave number, after which the wave becomes non-damped. These critical wave numbers are estimated asymptotically. By numerical investigation the additional resonance peaks were discovered which also correspond to the higher order edge waves. The reason of this phenomenon is discussed.


Antimicrobial resistance is a significant global health problem that is increasing worldwide. About 700,000 people die each year from antimicrobial resistant infections. This coupled with the high burden of infectious disease, a high population density, and weak health systems makes Nigeria a priority country for interventions targeted at reducing the occurrence of resistant infections and ultimately lowering the disease burden. One way to achieve this is by instituting Antimicrobial Stewardship Programs (ASPs) in our health facilities which aim at improving patient health outcome. The extent to which this has been achieved in Nigeria is unknown and this paper seeks to explore this. We conducted a cross sectional study on 14 hospitals selected from six states and the Federal Capital Territory (FCT) in Nigeria. The study utilises a questionnaire designed and scripted into Open Data Kit (ODK) to assess the needs of an ASP in a hospital setting. We found that only a few hospitals have AMS structures in place 11(78.6%). In addition, patients are not engaged in AMS activities across hospitals which is a requirement for ASPs to be successful. Overall, the study has identified gaps in the AMS program which can be leveraged to improve AMS within hospital settings. Moreover, the results underscores the urgent need to establish and strengthen AMS programs in Nigeria to help reduce the disease burden and improve health outcomes of the population.


While an increasing number of degree and professional development courses for librarians has become available online, training and continuing education for library support staff has remained largely a local, on-the-job effort. Typically, library assistants are taught the specific job for which they are hired, and do not receive the kind of broad-based orientation to their library's mission, policies, and procedures that would help them to place their work in a broader context. In order to address this situation, a pilot project was conducted in three libraries to develop and test an online course for academic and research library assistants that could be offered regularly for open enrollment. The paper is in two parts: (1) from the point of view of the project directors, how the pilot was designed, implemented, and evaluated; and (2) from the point of view of a staff development officer of one of the participating libraries, how the project affected the assistants who were selected to take the course. Lessons learned that will influence the course revision conclude the paper.


The invention belongs to the field of combined navigation and satellite navigation, and particularly relates to a combined satellite navigation positioning method with a combined correcting function. In a distributed filtering global positioning and strapdown inertial navigation system combined navigation method, an antenna unit (1), a radio-frequency front-end unit (2), a signal capturing unit (3), a signal tracking unit (4), a bit synchronizing and frame synchronizing unit (5), an inertia measuring unit (6), a strapdown resolving unit (7), an observed quantity converting unit (8), a combined filtering unit (9) and a correcting triggering unit (10) are used. Due to the adoption of the method, the kinesis and interference resistance of a global positioning subsystem are improved, the positioning accuracy of a combined system is further improved, and the working performance of a system in a complex environment is enhanced.


Based on the theory of evolutionary game, this paper using replication dynamic equations to analyze behaviors of banks and enterprises in the process of lending. Though the result of evolutionary game is a disappointment for rational people as the market is close to a failure, the government as an external force can promote a better relationship between banks and enterprises to mutual benefits for both parties.


This article refers to 'Temporal trends in initiation of mineralocorticoid receptor antagonists and risk of subsequent withdrawal in patients with heart failure: a nationwide study in Denmark from 2003–20 1 7' by D. Zahir et al. , published in this issue on pages 539–547. The steroidal mineralocorticoid receptor antagonists (MRAs) reduce mortality and hospitalizations for heart failure (HHF) in patients with heart failure and a reduced ejection fraction (HFrEF). Their incorporation into US and European guidelines as a class I indication for HFrEF held the promise for a substantial reduction in cardiovascular mortality, HHFs, and consequentially health care costs. It is therefore discouraging to observe that despite a class I indication in guidelines, over several years their use remains suboptimal in comparison to the other major guideline-recommended therapies for HFrEF. In this issue of the Journal, Zahir et al. 1 report upon the temporal trends in initiation and subsequent withdrawal of an MRA from a nationwide study of 5 1 5 1 2 patients with HFrEF in Denmark from 2003 to 20 1 7. They found that only 40% of patients initiated an MRA within 6 months of their heart failure (HF) diagnosis. Further-more, the use of an MRA did not increase significantly over the past decade. In those in whom an MRA was initiated, 49% of patients discontinued them and only 40% of these patients restarted them. The suboptimal use of MRAs in patients with HFrEF in Denmark 1 is unfortunately not unique. The US Get With the Guidelines Heart Failure Registry (GWTG-HF) 2 also found that the use of MRAs


The results of a combined experimental/numerical programme of research aimed at understanding the three-dimensional transient motion of fluid in spacer-filled channels at low Reynolds numbers are presented. The presence of regularly-repeating spacers in narrow channels promotes flow instabilities and mixing. Particle image velocimetry with refractive index matching was employed to measure the time- averaged flow field, and direct numerical simulations were also performed to obtain unsteady solutions to the Navier-Stokes equations. Generally good agreement was obtained between experimentally-observed and numerically-calculated velocity fields. In addition to observed velocity fields, obtained data include spectral power density of fluctuating flow field phenomena for a range of Reynolds numbers ranging from 100 to 1000.


In the two and a half months that passed between mid-August and late-October of 2011, the Bolivian government of Evo Morales entered into its worst crisis to date. From a high of 70 percent popularity in January 2010, Morales had plunged by mid-October 2011 to an average 35 percent approval rating across the major cities of La Paz, El Alto, Cochabamba, and Santa Cruz.2 The President's green light to a decades old project to build a highway connecting Villa Tunari (in the department of Cochabamba), north to San Ignacio de Moxos (in the department of Beni), through the indigenous territory and national park known as tipnis (Territorio Indígena del Parque Nacional Isiboro-Sécure), was the catalyst of crisis in this instance. Beginning on 15 August, lowland indigenous movements – in alliance with fractions of the highland indigenous movement, and later with the support of the urban labour movement – launched a 600-km, 65-day march of protest from Beni to La Paz to prevent the construction of the highway. The march, after having been denounced by state managers as an imperialist conspiracy, and violently repressed en route by police forces on 25 September, eventually forced the Morales government to capitulate to its demands, at least temporarily. There would be no road through tipnis. The bureaucratic leader of the principal highland indigenous peasant confederation (csutcb), Roberto Coraite, a prototypical steward of mas interests embedded in a popular organisation, embarrassed the government by calling the lowland indigenous protesters 'savages'.3 But the political fallout would


Objective To explore the eye irritation of Labrasol in different concentrations in rabbits and determine its safety extent. Methods Use Draize's scale to investigate the eye irritation of Labrasol in rabbits. Results It was found that Labrasol at concentrations of 0.5%,1.0%,1.5%,2.0% and 3.0% showed no eye irritations, while mild irritation at 5.0%. Conclusion The safety range of labrasol in an eye preparation was 0.5% to 3.0%.


The present invention provides a strong ROI detection algorithm robust real-time based on the lane, in order to achieve the corner detection, image separated into two parts, and are called close-range and long-term regional area, respectively, with Hough and hyperbolic of to solve the model. In the entire image mainly transverse gradient operator is filtered to increase computing speed real-time detection of the object, and a sliding window strategy ROI lane boundary diagram regional statistical gradient direction angle boundary noise Rejection gradient directional angle to ensure the accuracy of the lane detection; employed in prospective areas of hyperbolic model, mainly to undertake close-range as the initial parameters of the model parameters, and ultimately to finalize K parameters search strategy to achieve detection of the curve section. This algorithm is robust performance in more complex environments and road conditions, to provide real-time information consulting lane.


646 Background: Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate composed of trastuzumab, the cytotoxic agent DM1, and a stable thioether linker. The effects of T-DM1 exposure on safety in patients with HER2-positive locally advanced or MBC are reported. Methods: The exposure–safety analysis included 618 patients with pharmacokinetic (PK) data who received single-agent T-DM1 3.6 mg/kg q3w from five phase 2 or 3 studies: TDM4258g, TDM4374g, TDM4450g/BO21976, TDM4688g, and EMILIA. Exposure parameters observed in cycle 1 were T-DM1 conjugate AUC, T-DM1 conjugate Cmax, and DM1 Cmax, (no PK accumulation). Safety endpoints were worst grade of thrombocytopenia (TCP) or hepatotoxicity (HPT) by protocol definitions. A multivariate logistic regression analysis was conducted to evaluate the association of exposure and clinically relevant covariates with the probability of experiencing TCP or HPT. Platelet counts (PLT), alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin (TBL) ver...


To identify bottlenecks in health system that hinders the scaling up of important health intervention, particular for vulnerable population including poor families. To identify health system environment' that' would' support' the utilization of' health' insurance scheme for important interventions in child health survival.


This study examined male Saudi and Jordanian student complaint strategies when complaining about their academic advisors, instructors, classroom environments, and exams to a friend, a person in charge, or the complainee (complaint addressee). To achieve the study goals, a discourse completion test (DCT) with 10 scenarios was developed and distributed to 100 (50 Jordanian and 50 Saudis) male university students. It was found that the students used a wide range of strategies that were both threatening and less threatening strategies, and had control in some situations, but were offensive in others. The Saudi students used a greater number of speech acts to complain than the Jordanian students. Further research suggestions are also given.


: Apoptosis, the cell's natural mechanism for death, may be a promising target for antitumor therapy. each the intrinsic and adscititious pathways use caspases to hold out programmed cell death through the cleavage of many proteins. In cancer, the apoptotic pathway is usually pent-up through a wide sort of means that together with overexpression of anti-apoptotic proteins and under-expression of pro-apoptotic proteins. several of those changes cause intrinsic resistance to the foremost common anticancer medical aid, therapy. Promising new antitumor therapies square measure plant-derived compounds that exhibit antitumor activity through activating the apoptotic pathway.


Although the main focus of this study is on the mother figure, it offers an exhaustive examination of Peter Weiss's oeuvre, including his less known early Swedish works. It is unique in that the author, who is a native of Sweden, bases her analysis on firsthand information which she obtained from personal interviews conducted in Sweden with Weiss's sister, his widow, his first wife, and his daughter.


Aquaponic agriculture is a sustainable ecosystem that relies on a symbiotic relationship between fish and macrophytes. While the practice has been growing in popularity, relatively little mathematical models exist which aim to study the system processes. In this paper, we present a system of ODEs which aims to mathematically model the population and concetrations dynamics present in an aquaponic environment. Values of the parameters in the system are estimated from the literature so that simulated results can be presented to illustrate the nature of the solutions to the system. As well, a brief sensitivity analysis is performed in order to identify redundant parameters and highlight those which may need more reliable estimates. Specifically, an inverse problem with manufactured data for fish and plants is presented to demonstrate the ability of the collage theorem to recover parameter estimates.


The fundamental idea that we seek to establish in this chapter is that the establishment of regional or local, peace calls forth global peace. In other words, our argument is that local and regional conflicts are partly driven by global factors, especially what is commonly known as international tension. In order to achieve meaningful and sustained peace, there is a reason to believe that it is mandatory to manage and contain international tensions. The main thesis of this chapter is to explain or posit, conflicts as a product of continuing international chasms, splits and differences of political and social ideologies in our modern world. Thus, we argue that conflicts are, to some extent, driven by international tension or global, ideological and geo-political factors. Notwithstanding the global influence, local factors – such as income inequality, income growth or lack of it, political institutions – can and do exacerbate conflicts and a peaceful resolution of conflicts becomes a difficult phenomenon.


This paper analyzes the output characteristics of a small generator. The output circuit is connected to the series of a resistance and an LED. The output voltage of the generator is calculated by the flux tube method. The output current flowing through the LED is calculated by the MATLAB/Simulink. The validation of the results obtained from this method is carried out by comparing the experimental results.


This paper deals with a bibliographic database dedicated to the comparison between numerical results and in situ measurements for geotechnical structures. This database, called MOMIS, has been developed by LCPC and ECN for several years. To date, it comprises a total of 416 case histories. The generation of MOMIS has relied on a technologic watch in the field of numerical modelling. The database can be used to highlight modelling principles (in order to provide a guide for good modelling practice to users) and deviations between results given by numerical models and values measured on actual geotechnical structures. It also reflects the evolution of the accuracy of numerical computations.


Stock price prediction targets to predict the future development direction of the stock market and the degree of rise and fall of the stock price according to stock market quotations. However, since the stock price has high nonlinear, high noisy, and dynamic characteristics, it is challenging to predict stock prices. This paper predicts stock price prediction with a long-short term memory (LSTM) model according to the above data characteristics. First, because the stock price is distributed in different price ranges, we pre-process the data by normalizing all the data to the range of 0 to 1. Then, we improve the model performance by adjusting the three main parameters, hidden layers, learning rate, and time window. LSTM adds a control part into LSTM to further catch these data to make the best of historical data. We compare the proposed method with Recurrent Neural Network (RNN) on a related dataset with relative root mean square error (RRMSE), mean absolute error (MAE) and mean absolute error percentage (MAPE). The lower the score on all three indicators, the more accurate the prediction. The experimental results show that the scores of LSTM are lower than RNN in three indicators, so its prediction is more accurate than RNN with appropriate parameters. Our analyses illustrate that LSTM can better predict the dynamic non-linear data like a stock price by considering the historical data.


Small and Medium Enterprises (SMEs) are perceived as the engine of economic growth in Kenya but face a formidable task of competing and surviving in the global market. Information and Communication Technology (ICT) a major driving force of globalization offer unique opportunities to SMEs, empowering them to participate in the globalised economy. However ICT use in SMES remains low. This study was carried out to investigate the determinants of ICT adoption and use by SMEs in Thika Municipality in Kenya. A cross-sectional survey of 75 SMEs was carried out; stratified random sampling was used to draw the sample from the total population of 240 SMEs. Structured questionnaires were used to collect data which was analyzed using descriptive statistics. Findings indicated an ICT adoption index of 68 %; mobile phones were the most adopted and used ICT, followed by computers and fixed phones. Most enterprises used ICT for basic applications of communication and office automation. Use of more advanced ICT applications was very low and only 28% of the enterprises had a web page. ICT adoption was more influenced by internal enterprise factors which include ICT knowledge and skills of the manager/owner and employees, identified need for ICT/ perceived usefulness of ICT in the enterprise, availability of funds, type of market and business operations. The study recommends stepping up ICT awareness and training among SMEs owners, employees and the public, formulation of supportive policies, subsidizing the cost of ICT and development of customized ICT products and applications for SMEs.


Sol-gel—synthesis for preparation of pure yttrium aluminium garnet powder with small grain size is subject of this ongoing study. Starting materials were sulfates and chlorides of yttrium and aluminium. To obtain pure YAG (Y3A1SO1Z) pH during hydrolysis as well as temperature during calcination and conversion into YAG must be carefully chosen. Presence of water has an adverse effect on the degree of agglomeration. To avoid this the influence of dispersion liquids was studied and this led to optimized conditions for precipitation. Sintering behaviour is discussed.


Objective: To investigate the role of radiotherapy (RT) in patients who underwent hysterectomy for uterine carcinosarcoma (UCS). Methods: Patients with the International Federation of Gynecology and Obstetrics stage I– IVa UCS who were treated between 1990 and 2012 were identified retrospectively in a multiinstitutional database. Of 235 identified patients, 97 (41.3%) received adjuvant RT. Twentytwo patients with a history of previous pelvic RT were analyzed separately. Survival outcomes were assessed using the Kaplan-Meier method and Cox proportional hazards model. Results: Patients with a previous history of pelvic RT had poor survival outcomes, and 72.6% of these patients experienced locoregional recurrence; however, none received RT after a diagnosis of UCS. Univariate analyses revealed that pelvic lymphadenectomy (PLND) and para-aortic lymph node sampling were significant factors for locoregional recurrence-free survival (LRRFS) and disease-free survival (DFS). Among patients without previous pelvic RT, the percentage of locoregional failure was lower for those who received adjuvant RT than for those who did not (28.5% vs. 17.5%, p=0.107). Multivariate analysis revealed significant correlations between PLND and LRRFS, distant metastasis-free survival, and DFS. In subgroup analyses, RT significantly improved the 5-year LRRFS rate of patients who did not undergo PLND (52.7% vs. 18.7% for non-RT, p<0.001).


An overview of the controversial proposal for the major eukaryote taxon 'Excavata' is presented. Euglenozoa. These 'excavates' have broadly similar flagellar apparatus organizations, for which a 'universal' terminology is provided. Most, but not all, of these organisms share a distinctive suspension-feeding groove, as well as some or all of a set of seven other proposed cytoskeletal apomorphies. Cladistic analyses of morphological data do not resolve high-level relationships within Excavata. Excavate-rich molecular phylogenies recover some robust clades, but do not support or strongly refute the monophyly of Excavata. A partial classification for excavates is presented, with phylogenetic diagnoses for Excavata and for two novel taxon names, Fornicata Introduction The last 15 years have seen unprecedented advances in our understanding of the relationships among eukaryotes. Some major, largely unexpected groupings have emerged, primarily through the application (and, sometimes, intelligently selective interpretation) of molecular phylogenetics. However, molecular phylogenetic approaches have limitations , which are nowhere revealed more starkly than in the stories of many of the supposedly 'deep-branching' eukaryotes, such as diplomonads (e.g. Giardia), parabasalids (e.g. Trichomonas), retortamonads, oxymonads, Hetero-lobosea and Euglenozoa. Earlier molecular phylogenetic evidence that these organisms represented a series of basal branches in the eukaryotic tree has been largely discredited of their true evolutionary positions have remained elusive, despite considerable efforts in gene, and even genome, sequencing. Nonetheless, it has recently been proposed that these problematic taxa form the bulk of a novel major clade of eukaryotes, which has recently acquired the formal moniker Excavata (Cavalier-Smith, 2002). The hypothesis is controversial – it draws support primarily from morphological data (O'Kelly, 1993; Simpson & Patterson, 1999) rather than from molecular phylogenies, which generally place organisms with very similar appearances in widely separated locations in the tree of eukaryotes (Simpson et al., 2002c). Conversely, some intriguing and robust lower-level relationships within Excavata have emerged from molecular phylogenetic studies, rather than from morphological comparisons (Dacks et al., 2001; Silberman et al., 2002; Simpson et al., 2002c). This paper reviews the diversity, morphology and evolutionary relationships of the relevant organisms, including: (i) the origins of Excavata as a phylogenetic concept; (ii) the cellular ultrastructure of the organisms involved, highlighting potential apomorphies and providing a standardized terminology; (iii) the relationships 'within' Excavata, as indicated by both morphological and molecular data; and (iv) phylogenetic definitions for the taxon and some clades that are predicted to lie within it. Origins: Excavata, excavate taxa and the excavate hypothesis …


Introduction With the introduction of the moving-fable technique, complete assessment of the aorta and lower extremities with 3D gadoliniumenhanced MRA (3D-Gd-MRA) has become feasible by sliding the field-of-view during contrast infusion (1). Several problems of the moving-table technique arise as the diagnostic requirements from the aorta to the calves are not uniform. For the small arteries in the calves, high-resolution imaging with long scan times is required which is limited by signal-to-noise and venous overlay (2). In the aorta, aneurysms or dissections can substantially alter the contrast kinetics resulting in delayed and non-uniform vessel fill-in (3). Long scan times degrade the evaluation of the renal arteries due to parenchymal or venous overlay (4). In addition, the different course of the arteries in the lower extremities require various orientations and dimensions of each scan volume for maximum coverage. To account for all these problems, a combination of different hardware and software features are necessary that address fundamentally different requirements for temporal and spatial resolution in a single automated exam.


Significance Social interaction deficits in drug users likely impede treatment, increase the burden of the affected families, and consequently contribute to the high costs for society associated with addiction. However, the neural origin contributing to altered social interaction in drug users is unknown thus far. The present study illuminates the nature of basic social interaction deficits as exemplified by social gaze behavior in cocaine users by applying behavioral, psychophysiological, and functional brain-imaging methods. The results suggest that basal social interaction impairments probably arise from blunted social reward processing that was again related to impaired real-life social behavior in cocaine users. These results point to the importance of reinstatement of social reward in the treatment of stimulant addiction. Social interaction deficits in drug users likely impede treatment, increase the burden of the affected families, and consequently contribute to the high costs for society associated with addiction. Despite its significance, the neural basis of altered social interaction in drug users is currently unknown. Therefore, we investigated basal social gaze behavior in cocaine users by applying behavioral, psychophysiological, and functional brain-imaging methods. In study I, 80 regular cocaine users and 63 healthy controls completed an interactive paradigm in which the participants' gaze was recorded by an eye-tracking device that controlled the gaze of an anthropomorphic virtual character. Valence ratings of different eye-contact conditions revealed that cocaine users show diminished emotional engagement in social interaction, which was also supported by reduced pupil responses. Study II investigated the neural underpinnings of changes in social reward processing observed in study I. Sixteen cocaine users and 16 controls completed a similar interaction paradigm as used in study I while undergoing functional magnetic resonance imaging. In response to social interaction, cocaine users displayed decreased activation of the medial orbitofrontal cortex, a key region of reward processing. Moreover, blunted activation of the medial orbitofrontal cortex was significantly correlated with a decreased social network size, reflecting problems in real-life social behavior because of reduced social reward. In conclusion, basic social interaction deficits in cocaine users as observed here may arise from altered social reward processing. Consequently, these results point to the importance of reinstatement of social reward in the treatment of stimulant addiction.


I AM deeply grateful for the honor of being thought worthy to join the parade of distinguished physicians who, almost every year for a century and a half, have delivered formal addresses on this oc...


Scientific innovation plays a surprisingly large role in societal trends and there's no reason why makeup and subsequently the hair colour market should be left out of the fun. The concept of hair makeup is not entirely new. Current pearl and pigment technologies, combined with consumers' changing temporary hair colour needs, have opened up new avenues in hair makeup applications.


Webometrics is concerned with measuring forms of the web: web pages, words in web pages, parts of web pages, websites, etc. Websites of 10 Central Universities in North East India are examined. The study calculates the link pages, the number of web pages, and analysis the Web Impact Factor of Central universities in North East India and the result found that the Tezpur University occupies first place with the highest Domain & Page Authority, External Equity-Passing Links and Total External links. While, Mizoram University leads with the highest Internal Equity-Passing Links, Total Equity-Passing Links, Total Internal links and Total links. After analysing the websites of these 10 Central Universities of North East India, the result reveals that Web Impact Factor of Mizoram University (MZU) occupies at top position with 83.54 SWIF, 52.73 IWIF and 30.80 EWIF among the other Central Universities Websites in North East India.


A 57-year-old woman was referred to the emergency department after a CT scan ordered by her general practitioner to investigate her abdominal pain showed a large cystic mass. The simple cystic appearance with its location in the small bowel mesentery prompted a provisional diagnosis of cystic lymphangioma. However, concerns regarding the size, location and local involvement of neurovascular structures presented a technical surgical challenge. Here we present a case of minimally invasive laparoscopic drainage using a modified Jackson-Pratt drain that avoided a laparotomy and open resection.


The thorough study of coherent electron cooling, the modern cooling technique capable to deal with accelerators operating in the range of few TeVs [1], raises many interesting questions. One of them is a shielding dynamics of a hadron in an electron beam. Now this effect is computed analytically in the infinite beam approximation [2]. Many effects are drastically different in finite and infinite plasmas. Here we propose a method to compute the dynamical shielding effect in a finite cylindrical plasma 1 - the realistic model of an electron beam in accelerators.


The oil and gas fields of the Bolshekhetskaya depression are characterized by significant remoteness from the existing infrastructures (roads, power lines, pipelines), as well as the severe Extreme North climatic conditions of the Yamalo-Nenets Autonomous District. The authors have worked out a complex approach to developing fields in this region to ensure a high hydrocarbon recovery level with economically viable indicators. The use of innovative solutions was tested at Pyakyakhinskoe field of the Bolshekhetskaya depression where commercial production started in 2016.

 The development method worked out by the authors (S.A. Solyanov, M.G. Mavletdinov, A.V. Zaytsev) is unprecedented and was patented in 2016 (invention 2635926, 2017). The benefit of this development system is the cellular structure of the development elements consisting of seven horizontal or multihole wells, which allows exercising efficient control over development and also regulating voidage replacement in each cell. The development system is closed, which allows starting well development by cells.
 The well construction technology was improved to implement the proposed development system with the use of multihole wells. The substantiation of this technology implies the application of only the standard drilling and geological steering equipment.

 Today, two targets with the main oil reserves, BU151 and BU152, are completely drilled with wells using the proposed development system and commissioned at Pyakyakhinskoe field. The current target development data confirm the forecast efficiency indicators and also the high efficiency of the developed technological and operating solutions. It is decided to apply this development system to other analogous targets of the Bolshekhetskaya depression. Well technologies with multizone hydraulic fracturing and multihole wells with a different number of wellbores were introduced and technologies of insulating separate intervals were tested for gas-condensate targets.
 These well technologies allowed increasing the commercial construction rate by 22.0-41.3% (depending on the drilled targets) and ensuring 100% successful liner running into the main horizontal section without additional activities and technical means.

 The development method worked out by the authors (S.A. Solyanov, M.G. Mavletdinov, A.V. Zaytsev) and implemented at oil targets of Pyakyakhinskoe field is unprecedented and was patented in 2016 (invention 2635926, 2017). The efficiency of using the closed development system based on horizontal injection wells and multihole horizontal production wells is confirmed with the actual well operation values, the planned indicators have been achieved in full measure. The production company has decided to apply this system to other targets.


Background: Inflammatory bowel disease (IBD) occurs frequently in industrially developed societies, and studies have shown that the highest reported prevalence was in Europe and North America. Sexual Dysfunction (SD) seems that could affect patients with IBD and this is a finding that is widely studied with the use of standardized tools. The aim of the present study is to approach the sexual dysfunction issue in patients with IBD through the most recent biographic data, focusing on the nurses' role, which can significantly contribute to the improvement of the care provided to those patients.
Findings: According to the definition of the World Health Organization, sexual health is a state of physical, emotional, mental, and social well-being in relation to sexuality, and it is not merely the absence of disease, dysfunction, or infirmity. Sexual health is a basic determinant for the health quality of a person and is correlated with the subjective perception that an individual has, into the context of their values, culture, educational level, and the role models in their life. Patients with IBD are highly concerned for their sexual life as a result of the negative self-image, whereas, the difference of SD before and after the surgery is quite significant, with a clear burden after the surgery, regardless if the operation included an ileostomy or not. The investigation of SD is a difficult procedure for the health care workers but it can take place via a patient's holistic management. In order for a patient to express a dysfunction it is of paramount importance that feelings of confidence in doctors, nurses and the rest of the team be strengthened.


Swedish levels of punishment regarding serious violent crime are often perceived as low. The public is discontented.

The Swedish government has since 2006 pursued a reform agenda with the purpose of toughening penalties for serious violent crimes. The Government has invoked the Volksgeist as the basis of its reform agenda. Meanwhile, the new legislation has not been effective in the application of law due to a reluctant judiciary. The trend has instead partially gone in a contrary direction.

This paper examines the question: Why are the levels of punishment so low in Sweden?

The following questions are, inter alia, answered in the essay.

How is sentencing done in Sweden?
How is recidivism dealt with?
What sanctions are there and how are sanctions chosen?
What is the penal theoretical basis for the current levels of punishment?
Why are the levels of punishment so low in Sweden?

The conclusion is that the low level of punishment in Sweden is mainly due to Nordic neo-classical influence. Representatives of Nordic neo-classicism, a penal theoretical movement, used, in a penal theoretical transition period in which demands for tougher penalties and stricter enforcement, penal theoretical elements that appealed to a liberal or conservative audience, in a new combined theory. As the purpose of this combined theory was to lax penalties, this was in practical sense a drawback for these political groups. Hence, Nordic neo-classicism should not be seen as a compromise between conservatives and radicals. Nordic neo-classicism has since then largely managed to kidnap Swedish criminal policy for its radical, and from the Volksgeist strongly divergent purposes of lax punishment policy.

Today, neo-classicists hold key positions in the Swedish society, in universities and in the Supreme Court. This technocratic rule of experts is now wrestling with a populist right-wing government that has tougher penalty measures far up on its agenda.

The essay also contains a draft with some ideas for a new combined penal theory for the Swedish penal system.


A 62-year-old man with a heavy background of the right upper lobe squamous cell carcinoma was admitted with massive hemoptysis. Computerized tomography (CT) showed a large right upper lobe lesion with infiltration of mediastinum and airways. A right pulmonary artery pseudoaneurysm slightly bulging into the right main bronchus was seen, suspicious for a pulmonary artery bronchial fistula. A combined endotracheal and angiographic approach was done. The right pulmonary artery angiogram showed a now occluded neck to the pseudoaneurysm which was selectively cannulated. Framing and packing coils were deployed. Contrast was endoscopically noted without bronchial bleeding. As the coils were entering the lung parenchyma, packing back to the neck was done carefully. No new bleeding was noted. A bronchial stent was inserted 6 weeks later and one coil protruding into the bronchus was seen. A 3 month CT follow-up did not show any residual pseudoaneurysm. Patient died 3 months after initial procedure of his progressive illness. Only three cases of endovascular management of bronchial-pulmonary artery fistula reported with different techniques including pulmonary artery stenting. Our case is the only one reported treated with only coil embolization. Limited data are available regarding the risk of pulmonary embolism after stenting. Anticoagulation required after stenting increases the risk of bleeding in patients with severe hemoptysis. Management with coils only facilitates further management. This preserves pulmonary circulation in patients with already compromised respiratory function. Coil only embolization of uncommon pulmonary artery bronchial fistula is feasible and facilitates further management as it does not require anticoagulation in patient with recurrent bleeding.


Based upon a method of Hanbury-Brown and Twiss, while considering the nonstationary characteristics of synchrotron radiation (SR), a novel optical intensity interferometer was constructed to extract the true two-photon correlation of soft x-ray SR. This intensity interferometer consists of an optical vacuum chamber, which includes a wire scanner, a beam divider, and a grating monochromator with a coherence time modulator, and of an electric correlator which completes the multiplication of two broadband electric currents. The technique of coherence time modulation, together with the two bandpass filters in the correlator, play an essential role to cancel a huge trivial correlation, which arises from the accidental coincidence between a pair of divided pulses being largely enhanced by the finite slow time response of the detection system compared to the coherence time of the photon. A preliminary performance test was conducted, and the results exhibit satisfactory functions of this interferometer.


A New method for the preparation of pyrrolo [1,4]benzodiazepinone derivatives using palladium-catalysed carbonylation has led to a formal synthesis of anthramycin.


THE trouble with Courtly Love is that it gives its lovers no rest, and the modern critical devotee is hardly less jealous for his favorite theory of its nature and source than was the troubadour. Ovid is out of the game by now, whatever that genial professor added to the science in the twelfth century; for, where man is ennobled by the soaring fire of Courtlyfin' amors, the De amore teaches a view of sex which-as William of St. Thiery, following the hint of


Local and general effects emerging in organism in consequence of its impact with an aggression evince the intensity of aggression along with the amplitude of the response in the organism. The aim of our study was to observe the disturbances of antioxidant capacity, expressed by Superoxide Dismutase (SOD) and Glutathion Peroxidase (GPx) in children with oral and maxillofacial trauma. Material and method. The study group consisted of 30 politraumatised children (aged 10 to 16 years) with oral and maxillofacial trauma. The patients were hospitalized in the Intensive Care Unit of Constanta Clinical Hospital. The parameters (SOD, GPx) were determined in three different periods of their evolution: T1 – the first 6 hours after admission, T2 – after 48 hours and T3 – 7 days after injury. The results obtained put into evidence the statistically significant decreased SOD levels at 7 days after injury in comparison with the first two determinations. The levels of GPx were statistically significant decreased after 48 hours and 7 days postinjury in comparison with GPx levels at the time of the first determination (T1). Conclusion. Monitoring levels of antioxidants in patients with oral and maxillofacial injuries may be useful during therapy for the evolution and prognostic.


BACKGROUND
The transanal approach to ileal pouch-anal anastomosis (Ta-IPAA) provides better access to the lower pelvis with lower short-term morbidity in ulcerative colitis (UC). The aim of this study was to assess the long-term functional outcomes after Ta-IPAA versus transabdominal IPAA (Abd-IPAA) in UC.

STUDY DESIGN
A multicentre cohort analysis was done between March 2002 and September 2017. Patient characteristics, surgical details and postoperative outcomes were compared. CGQL (Cleveland global quality of life) score at 12 months with a functioning pouch was considered the primary endpoint.

RESULTS
A total of 374 patients (100 Ta-IPAA vs 274 Abd-IPAA) were included. Ta-IPAA demonstrated a comparable overall quality of life (CGQL score) to Abd-IPAA (0.75 ± 0.11 vs 0.71 ± 0.14; respectively, p=0.1). Quality of life (7.71 ± 1.17 vs 7.30 ± 1.46; p=0.04) and energy level items (7.16 ± 1.52 vs 6.66 ± 1.68; p=0.03) were significantly better after Ta-IPAA, while the quality of health item was comparable (7.68 ± 1.26 vs 7.64 ± 1.44; p=0.96). Analysis excluding anastomotic leaks did not change the overall CGQL scores. Stool frequencies (>10/ 24 hrs:22% vs 21%; p=1.0) and the rate of single episode of major incontinence during the 12-month period (27% vs 26%; p=0.89) were similar. The differences in thirty-day morbidity rates (33% vs 41%; p=0.2) and the anastomotic leak rates were not significant (6% vs 13%; p=0.09).

CONCLUSION AND RELEVANCE
This study provides evidence of comparable long-term functional outcome and quality of life after Ta-IPAA and Abd-IPAA for UC.


OF THE DISCLOSUIRE An improvement in a process for utilization of the energy content of the flue gas accrued in catalytic cracking plants and for the economic control of such cracking plants, to thereby improve the entire effectiveness of such a plant and its adaptability to various operating condi tions. The process comprises the steps of supplying the combustion air required for the regeneration of the cata lyst to the regenerator by a compressor, supplying the ac crued flue gas to an exhaust gas turbine by a cyclone being independent of said regenerator, said exhaust gas turbine is arranged particularly to drive a generator, burning the combustible part of CO contained in the flue gas in a cata lytic CO boiler following the turbine, supplying the sur plus air resulting from a slighter requirement of combus tion air for heating to said CO boiler by means of a line (bypass line) leading past the cracking process and branch ing off between said compressor and said regenerator and mixing said surplus air to the flue gas coming from the regenerator before said cyclone.


ABSTRACT The evolution of magnetic loss of FeSiAl/carbonyl iron powder cores annealed at different temperatures was investigated. The experimental results reveal that the magnetic permeability of FeSiAl/carbonyl iron core increases as the annealing temperature increases, but it almost remains constant when annealing temperature higher than 650°C. The magnetic loss of the core first decreases with the increase of the annealing temperature, reaches a minimum at about 640°C, and then starts to increase with further annealing temperature increasing. It is found in loss separation that both hysteresis loss and excess loss decrease with the increase of annealing temperature before 640°C, which can be attributed to the reduction of effective anisotropy caused by stress relief. However, the eddy current loss increases with annealing temperature increasing when it is higher than 650°C, which may be the result of the degradation of the surface insulation layer caused by the high temperature annealing.


A pseudoaneurysm, also termed a false aneurysm, is a leakage of blood from an artery into the surrounding tissue with persistent communication between the originating artery and the terminating blood-filled cavity. Pseudoaneurysms involving the uterine arteries are rare and can be a complication of pregnancy, pelvic surgery, or pelvic trauma. Presenting symptoms include persistent vaginal bleeding and pelvic pain. The detection and diagnosis of a uterine artery pseudoaneurysm is important because of the potential for rupture and hemorrhage, which could be lethal. A variety of treatment options are available, with embolization being the most common.


This article gives an introduction to the conservation tillage applications in Dalian area, expounds on the production process and the related agricultural machinery, explores the effect of conservation tillage and economic benefit in a bid to provide reference for promoting conservation tillage technology in Dalian area.


In the work a meta-model of electrical power network is created combining different sets of data. Analysis over this set of data is made, and a methodology for electrical consummation prediction is given. The algorithm is based on weather condition predictions and information about population -- mitigation and work days.


The temperature dependence of interdot spin-transfer dynamics at laterally coupled excited states (ESs) in high-density InGaAs quantum dots (QDs) was studied using spin- and time-resolved photoluminescence spectroscopy. At low temperatures below 100 K, temporary suppression of electron-spin polarization decay due to selective relaxation of minority spins from emissive ESs to lower-energy states in neighboring QDs was observed. In the temperature range from 20 K to 140 K, thermal activation of electron spins from lower-energy QD states to higher-energy states via interdot transfer prevents the aforementioned selective relaxation of minority spins, leading to a faster decay of electron-spin polarization during light emission. At high temperatures above 140 K, reinjection of depolarized electron spins from barriers after thermal escape from QD ESs accelerates the further decay of the electron-spin polarization, wherein the electron spins can be activated via ladderlike interdot transfer. These findings indicate that the suppression of reinjection of electron spins from barriers in a high-density QD system is crucial for maintaining high electron-spin polarization during light emission at high temperatures.


Multi-media systems capture, generate, store and render data from a variety of non-textural media-not just video. Yet compared with the world of text, only a few relatively puny mechanisms for indexing and retrieval are provided. A method for automatically indexing any timestamped data set is described. It is being studied as part of an activity to build and evaluate a system to aid human recall, called the AIR project, (activity-based information retrieval). It is being designed to help people retrieve things from 'memory' that they would otherwise find difficult or impossible to retrieve, because, for example, they would not normally keep records on the subject. This system has been called a human memory prosthesis. It exploits a suggested autobiographical model of human memory which observes that one way that humans seem to organize their memory is in episodes. The AIR project team is interested in providing mechanisms for recalling a variety of types of data ranging from electronic or paper documents, information design notes, seminars, snatches of explanations, and impromptu 'how to' tutorials.


A simple variation in the method of incipient wetness can dramatically improve metal dispersion in supported metal catalysts. This very common method, also known as dry impregnation or pore filling, often suffers from the absence of metal precursor-support interaction during metal deposition, which usually leads to extensive sintering and poor distribution of the metal phase after pretreatment. In past work, our group has demonstrated the synthesis of ultrasmall nanoparticles in tight size distributions by inducing strong electrostatic interactions between the dissolved metal precursor and support. We have normally employed "wet impregnation" involving thin solution-support slurries, but now show that electrostatic interactions can be induced at incipient wetness. This is done by acidifying or basifying the impregnating solution to the (surprisingly) great extent needed to charge up the surface. With this simple variation we have demonstrated vast improvements in Pt dispersion over carbon, silica, and alu...


The effect of bandgap engineering on IC-VBE flyback characteristic of power SiGe heterojunction bipolar transistor is studied through theoretical analysis, computer simulations, and experimental measurements. It is found that because of the existence of Ge composition, SiGe Heterojunction Bipolar Transistors have better thermal stability compared with homojunction bipolar transistors under the same operating condition which will be beneficial to decrease the emitter ballast resistance of HBT and improve the performance of transistor. And the greater Ge composition is, the more stable the HBT is.


Abstract Porous asphalt concrete (PAC) have a typical big void-skeleton structure, and porous asphalt mixtures with large voids are more prone to freeze–thaw damage. As a result, research on the influence of freeze–thaw cycles on the micro-structure and mechanical characteristics of porous asphalt mixes offers a theoretical framework for overcoming water stability concerns in porous asphalt mixtures in practice, as well as for further popularization and application. In this study, styrene–butadiene–styrene (SBS)-modified asphalt and high viscosity modified asphalt were constructed on the basis of the original asphalt, and the mix proportions of asphalt mixes PAC-13, AC-13, and SMA-13 were designed. To begin, molecular dynamics simulations were used to look into the effects of freeze–thaw cycles on asphalt–aggregate interface adhesion and mixture micro-mechanical properties. Second, the effects of freeze–thaw cycles on the void characteristics of porous asphalt mixtures were explored utilizing digital image processing technologies. Finally, the freeze–thaw split test was utilized to evaluate the macroscopic mechanical properties of a porous asphalt mixture after freezing and thawing cycles. According to the study findings, high viscosity modified asphalt made with 4% SBS/8% TPS has the greatest performance. The application of SBS/TPS-modified asphalt can considerably improve the damage resistance of porous asphalt mixes. The micro-structure and mechanical qualities of porous asphalt mixtures are damaged by freeze–thaw cycles, and the damage gets worse as the number of cycles rises. The study's conclusions provide a theoretical justification for the application of porous asphalt pavement.


The stability of neutral systems with two cross-talking delays is investigated using the method of cluster treatment of characteristic roots (CTCR). There are two main outcomes of this study: (a) we create the "strong stabilizability" (also called the "delay stabilizability") of the system directly from the CTCR procedure. This is achieved by a small-delay stability treatment while performing the steps of the CTCR. For the "delay-stabilizable systems," we also arrive at the exact bounds of the stability regions in the domain of the delays. (b) We deploy a point-wise algorithm which computes the rightmost roots of the characteristic quasi polynomial for cross-verification of these stability regions. Several examples are presented. The correspondence between the two methods for all of them is shown to be very strong.


In order to improve the protective efficacy of inactive vaccine against actinobacillus pleuropneumoniae,six recom- binant proteins(rApxⅠ,rApxⅡ,rApxⅢ,rApxⅣ,rApfa and rOMP)were examined for their ability to enhance the effectiveness of the inactive vaccine of APP7.Groups of BALB/c mice were inoculated with inactive vaccine(groupⅠ),recombinant subunit vaccine containing inactive vaccine,rApxⅠ,rApxⅡ,rApxⅢand rOMP(groupⅡ);inactive vaccine,rApxⅠ,rApxⅡ,rApxⅢand rApxⅣ(groupⅢ);inactive vaccine,rApxⅠ,rApxⅡ,rApxⅢand rApfa(groupⅣ),and PBS only(control group),at day 0 and 14 and 28,respectively.Antibody level was tested weekly and T lymphocytes proliferation and IFN-γproduction were examined at days 13,27 and 34 post vaccination.The mice were challenged intranasally with serotype 1(5×10~9 CFU)and serotype 7(1×10~(11) CFU)at day 35.The results showed that the groupⅡhad a higher level of antibodies to ApxⅠand OMP,T lymphocytes proliferation and IFN-γproduction than others groups(P0.05),and a better protection against challenges by serotype 1 and serotype 7.The levels of humoral immunity and cell immunity had a positive correlation to protective efficacy. These results demonstrated that supplement of recombinant proteins in inactive vaccine improved vaccine efficacy.The recombinant subunit vaccine containing inactive vaccine,rApxⅠ,rApxⅡ,rApx 2 and rOMP provided significantly better protection by stimulating humoral immunity and cell immunity simultaneously.


In this paper, we present the FOLtoNL system, which converts first order logic (FOL) sentences into natural language (NL) ones. The motivation comes from an intelligent tutoring system teaching logic as a knowledge representation language, where we use it as a means for feedback to the users. FOL to NL conversion is achieved by using a rule-based approach, where we exploit the pattern matching capabilities of rules. The system consists of a rulebased system and a lexicon. The expert system implements the conversion algorithm, which is based on a linguistic analysis of a FOL sentence, and the lexicon provides grammatical information that helps in producing the NL sentence. The whole system is implemented in Jess, a java-based expert system shell. The FOLtoNL is not complete in all its aspects yet.


The relaxation rate in Nb-doped strontium titanate involving different scattering channels is investigated theoretically. It is demonstrated that the total relaxation rate in SrTiO_{3} is provided mainly by two mechanisms. The Baber electron-electron scattering with participation of both Coulomb and phonon-mediated electron-electron interactions provides the T^{2}-dependence of the relaxation rate. The scattering on the potential landscape caused by impurities is responsible for the residual relaxation rate at low temperatures. A good agreement with experiment is achieved accounting for all phonon branches in strontium titanate, both the optical and acoustic phonons. It is shown that the effective electron-electron interaction can be attractive in strontium titanate, and provides superconductivity at low temperatures and Fermi-liquid response in a wide range of temperatures. Thus our microscopic model supports the notion that superconductivity and Fermi-liquid properties of n-type SrTiO_{3} have a common origin.


ABSTRACT Recovery of valuable metals is hindered by sulfur in cyanide tailings. In this work, a process for the clean recovery of multiple valuable metals through chlorination roasting was proposed. HSC software was used to find that the process of dissociation of chlorides is further accelerated by sulfur in the tailings. Experiments were carried out to study temperature variables and chlorinated agent variables. The optimum conditions were identified to be a CaCl2 dosage of 4%, roasting temperature of 1323 K, achieved maximum recovery of 84% of Au, 71% of Ag, 72% of Cu, 92% of Pb, and 69% of Zn.


This cross-sectional study was designed to test a model of burnout among mental health nurses employed in a psychiatric hospital in Atlantic Canada. The model included the variables job satisfaction, role ambiguity, role conflict, workload, social support, perception of personal safety, age, education, work experience, and the three dimensions of burnout: emotional exhaustion, depersonalization, and personal accomplishment. The sample consisted of 115 registered nurses and licensed practical nurses. -- The rate of burnout within the sample was 8.1 %, although more than 40.0% of the sample reported high levels of emotional exhaustion, or depersonalization, or low levels of personal accomplishment. Nearly half of the participants reported high levels of concern for their personal safety in the workplace. Bivariate analyses demonstrated significant correlations between a number of the study variables. Multiple linear regressions indicated that job satisfaction, role conflict, and workload were the best predictors of the three dimensions of burnout. Specifically, role conflict was a significant predictor of all three dimensions of burnout, while job satisfaction was a significant predictor of emotional exhaustion and personal accomplishment, and workload was a significant predictor of depersonalization and personal accomplishment. The perception of personal safety was significantly correlated with all three dimensions of burnout, job satisfaction, role conflict, role ambiguity, workload, and social support, but it was not found to be a significant predictor in the model of burnout used in this research. -- The results of this study have implications for nursing practice, education, theory, and research. At a time when the nursing profession in Canada is aging and experiencing mass retirement, this research provides relevant information for the prevention of burnout among mental health nurses that can improve the retention of experienced nurses and the recruitment of new nurses.


In 1946, despite the censorship of the American Occupation, Kurihara Sadako published Kuroi tamago (Black Eggs), poems from before, during, and immediately after World War II. This volume includes a translation of Kuroi tamago (the complete edition of 1983), as well as a large selection of her later poems.


For the class of general neutral multi delay systems with measurable and non-measurable (unknown) disturbances, the problem of triangular decoupling with simultaneous distur-bance rejection, is studied via delayless dynamic and/or static controllers, feeding back the measurement outputs and the measurable disturbances. The necessary and sufficient conditions for the problem to have a solution via delayless dynamic controllers are established and the general form of the delayless dynamic controller matrices solving the problem are derived. For the delayless static controller case, the respective solvability conditions and general controller solutions are derived.


A field study with organic manures, inorganic manures and biofertilizers alone and in combination was carried out on 11-year-old mango (Mangifera indica L.) cv. Himsagar spaced 10 m apart in a randomized block design at the University Research Station, Gayeshpur, BCKV, West Bengal, India. The objective was to determine their effect on growth, soil characters, and fruit quality of mango grown in a new alluvial zone of West Bengal. Respiration, physiological loss in weight (PLW) and shelf life at ambient room temperatures, and soil characters were also assessed. Results revealed that among the eight treatments, biofertiliser (Azotobacter + PSM) along with 50% inorganic fertilizer significantly increased the growth characters of mango trees. This treatment also increased the physico-chemical character of fruit while biofertilizers alone improved the fruit quality, viz. total soluble solids, total sugar and β-carotene. Fruits treated with biofertilizers also had increased shelf life with lower PLW and respiration rate. Soil microbial population and other soil characters were improved by application of biofertilizer as well. It is concluded that biofertilizer application in mango gives better growth, fruit quality, and soil health.


Sharply increasing maternal mortality rates in some African countries during the 1980s and 1990s coincided with the rise of the HIV epidemic,


coronary artery disease, which have already benefited many hundreds of patients, have received little attention. The development of high quality coronary angiography has led to a better understanding of the coronary circulation and the pathological anatomy of these vessels. Morbid anatomical studies, haemodynamic investigations, and left ventriculography have allowed an assessment of the nature and frequency of the various conditions which are amenable to surgical treatment. The aspects of surgical treatment to be discussed in this paper may be classified broadly as, firstly, the treatment of the sequelae of infarction (both early and late complications and power failure), and, secondly, treatment of coronary


A new patch antenna system with a metamaterial cover is presented in this paper. The impedance, radiation pattern, and directivity of such an antenna are studied. A performance comparison between the conventional patch antenna and the new metamaterial patch antenna is given. The results show that the directivity of the metamaterial patch antenna is significantly improved. The effect of the metamaterial cover's layer numbers on the radiation pattern of the patch antenna is also studied.


Is scientific progress necessarily moral? In his history of experiments on human guinea pigs, Grégoire Chamayou attempts to show that modern science, although apparently neutral, has a share in the domination and exploitation of individuals whose existence is deemed insignificant. In November 2009, a World Health Organization study posted on the Lancet website stated that universal voluntary HIV testing followed by immediate antiretroviral therapy for all infected would strikingly reduce the incidence of HIV to one case per thousand per year by 2016. " To apply a mathematical model such as this, we would have to master a number of parameters, " remarked the director of the Agence Nationale de Recherche sur le Sida, in Le Monde, " including the screening of the 38 million people who are HIV-positive, 30 million of whom are not even aware of their condition, and who would have to accept therapy not so much for themselves as for the collective good. " That same week the murder, dismemberment, and sale for witchcraft of albino children in Burundi was made public. Nothing could be more dissimilar — at least one would think so — than a noble humanitarian ambition on a world scale and apparently ancient barbaric practices such as those in Burundi. Yet Grégoire Chamayou's book, Les Corps vils, blurs the all too practical distinction between enlightened science — which strives for the good of all mankind — and superstition — which is racist and criminal. He suggests that modern science has always depended, and probably continues to depend, on what he calls " dreadful rationality, " which implies the sacrifice of lives that are considered worthless and therefore available for exploitation.


This study explored whether artificial cues of others on social networking sites (SNS) have an effect on a user's tweeting behavior in frustrating situations. By manipulating artificial cues of others, we measured the statements posted by participants on a hypothetical SNS under two different experimental situations: one was the agent condition, in which task instructions were given by an assistant agent throughout the task, and the other was the control condition in which task instructions were given through a text box. In each condition, participants were first asked to read fictional stories including frustrating interpersonal and intrapersonal events and to adopt these situations as their own. Participants were then asked to tweet about their feelings on the hypothetical SNS. The negativity and aggressiveness of each statement in both conditions were assessed by other participants. Results demonstrate that the statements for the frustrating interpersonal event posted by participants under the agent condition were more often evaluated as non-negative and less often evaluated as negative-and-blaming-of-others than those posted under the control condition. Conversely, there was no difference between conditions in the statements for the frustrating intrapersonal event. These findings suggest that the implication of the presence of others, such as an assistant agent, in the tweeting environment inhibits disparaging tweeting behavior on SNS.


A thermal insulation of a spatial structure (1) comprising a multilayer heat insulator (2) comprising a stack of N layers (3, 4, 5), N being an integer greater than 3, comprising an outer layer (3 ) intended to face the space environment, intermediate layers (4) and an inner layer (5) facing a spatial structure (1), said layers being electrically conductive on their internal faces (3i, 4i, 5i) oriented spatial structure (1), characterized in that it further comprises at least one staircase (7), the bearings (3p, 4p, 5p) are portions of inner faces of successive layers (3i, 4i, 5i ) taken from the N layers, the (s) said (s) stairs (s) being arranged (s) so that each of the N layers comprises at least a portion of its inner side (3i, 4i, 5i) forming a bearing (3p, 4p, 5p) of a staircase (7), said device further comprising a grounding said N device layers including at least one electrically conductive element (6) deposited on the bearings (3p, 4p, 5p) of at least one staircase (7) so as to establish the electrical connection between the layers (3i, 4i, 5i) from which are formed bearings (3p, 4p, 5p) of said at least one staircase on which the electrically conductive element (6) is deposited.


The British Journal of Occupational Therapy is published on the 15th of each month by the College of Occupational Therapists Ltd (Registered Charity No. 275119) at 106-114 Borough High Street, Southwark, London SE1 1LB. Telephone: 020 745


The invention discloses a self-adaptive control device and a self-adaptive control method for an LED electric light source based on optimal light effect. The self-adaptive control device is characterized by comprising a rectifier module, a PFC module, an LED module, an MCU control module, a temperature detection module, an illumination detection module, a constant current driver module and a current detection module. According to the self-adaptive control device and the self-adaptive control method, the working current of the LED electric light source can be automatically adjusted through the MCU control module, so that the heat generated by the LED electric light source can be reduced, the working temperature of the LED electric light source is reduced, and then the light effect of the LED electric light source is improved, and the intelligentization of the LED electric light source is improved.


Besides geological mapping an important task of regional seabed mapping programmes such as MAREANO (Thorsnes, this volume) is relating geological and other environmental information to observations of benthic biology. In this way we can begin to develop maps indicating the distribution of ecologically relevant seabed environments and fauna occurring over the seafloor. Maps of this type have been given many names in the literature. The term 'habitat map' is perhaps the one most widely used but has also been adopted to describe maps including varying proportions of physical and biological information (e.g., Brown et al. 2005; Jordan et al. 2005; Kostylev et al. 2001; Lanier et al. 2007; Whitmire et al. 2007). Other related terms include marine landscapes (Golding et al. 2004, Al-Hamdani et al. 2007), seascapes (Day & Roff 2000), and biotopes (Foster-Smith et al. 2004).


Alzheimer's is a neurodegenerative disease characterized by the progressive deterioration of cognitive functions, with memory being the most affected. Several studies have shown the benefits of music as a complementary treatment for dementia, improving patients' quality of life. A scientific contribution is needed to show how autobiographic memory could be improved by using musical activities. Objective: The aim of this investigation is to analyze the impact of a musical stimulation protocol on the performance of autobiographical memory in elderly people suffering from Alzheimer's. Participants and Method: This research was conducted with three patients diagnosed with Alzheimer's disease: two females (66.7%), and one male (33.3%). One (33.3%) was in the early stages, and two were in the middle stages. This investigation used a quantitative, pre-experimental, longitudinal study with the application of two tests before and after the intervention. Findings: Changes in the performance of autobiographical memory (t=-5.79, p=0.002), and in the semantic component (t=-10.14, p=0.01) were found to be statistically significant, but no changes were evident for episodic memory (t=-0.19, p=0.86). Conclusion: This study provides preliminary evidence of the potential effectiveness of using a music protocol to improve the performance of autobiographical memory in patients with Alzheimer's Disease. Doi: 10.28991/esj-2021-01304 Full Text: PDF


This paper explores the information age in reference to wellbeing of humans. The world is geared up for so fast pace but is it fit for the biggest population of blue and white collar workers. It explores the beneficiaries of this information era boom and its bruises. It doesn't underestimate the need of technology and information rather it explores talks about the direction and the falling panorama of the pace. Economy is the backbone and the trim tab of society. Capacity of making business is the edge factor. This paper is revolving around business in the context of information age and the abiding effects of it. The convolutions of this paper are containing the evolution of information technology in business, corollary evolution of human resources, further it discusses that at the end of information age whether the machines will serve humans or the humans will serve machine. With the employment of more and more machines to cope up with the competing speeds, the man is about to get free from regular work. Is it the goal of the world?


Copyright © 2022 The Korean Society of Radiology Simplified Approach for Ovarian-Adnexal Reporting and Data System MRI Risk Stratification System Alireza Mohamadian , Behnaz Moradi 3 Department of Radiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran; Department of Radiology, Yas Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran


The hygroscopic behavior of carbonaceous aerosols has a significant impact on global and regional climate change. However, the mechanism and factors controlling the hygroscopicity of black carbon (BC) from different carbon sources are not well understood. Here, we systematically measured the equilibrium and kinetics of water uptake by 15 different BC (10 herb-derived BC, 2 wood-derived BC, and 3 soot) using gravimetric water vapor sorption method combined with in-situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS). In the gravimetric analysis, the sorption/desorption equilibrium isotherms were measured under continuous-stepwise water vapor pressure conditions, while the kinetics was measured at a variety of humidity levels obtained by different saturated aqueous salt solutions. The equilibrium water uptake of the BC pool at high relative humidity (> 80%) positively correlated to the dissolved mineral content (0.01–13.0wt%) (R = 0.96, P = 0.0001) as well as the content of the thermogravimetrically analyzed organic carbon (OCTGA, 4.48–15.25wt%) (R = 0.82, P = 0.0001) and the alkali-extracted organic carbon (OCAE, 0.14–8.39wt%) (R = 0.80, P = 0.0001). By contrast, no positive correlation was obtained with the content of total organic carbon or elemental carbon. Among the soluble ionic constituents, chloride, nitrate, and ammonium were each correlated with the equilibrium water uptake at high relative humidity. Compared with the herbal BC and soot, the woody BC had much lower equilibrium water uptake, especially at high relative humidity, likely due to the very low dissolved material content and OC content. The DRIFTS analysis provided generally consistent results at low relative humidity. The results indicated that the equilibrium water uptake by BC was mainly controlled by the hygroscopic constituents of OC and dissolved mineral. The kinetic water uptake by the BC could be well described by the pseudo-second order kinetics model. The calculated rate constant (k2) positively correlated to the contents OCTGA (R = 0.47, P = 0.0046), OCAE (R = 0.44, P = 0.0070), and NH4-, Cl-, and NO3-salts (R = 053–0.77, P = 0.0001–0.0021) under low humidity conditions, but to the total porosity only under high humidity conditions (R = 0.82, P = 0.0001). The fast water uptake kinetics under low humidity conditions was attributed to the binding to high affinity, active sites (OC and salts), whereas the slow water uptake kinetics under high humidity conditions was attributed to pore-filling/condensation of water molecules within the microand mesopores of BC. This study highlights that the hygroscopic properties of BC rely on compositional and structural properties of BC as well as humidity conditions.


Thiolated oligonucleotide is immobilized on the surface of gold-filled quartz crystal with self-assembly.Using the Piezoelectricity Biosensor which manufactured by our university,the quality of oligonucleotide is learned,and capabilities of the Piezoelectricity Biosensor are tested.


A jet propulsion engine such as a gas turbine engine has an air compressor for supplying compressed air to the engine compressor stages. The air compressor is controllably and selectively driven by way of a disconnectable drive connection between the air compressor and a freely rotatable fan which is arranged in front of the air compressor and which in operation is rotated by the flow of intake air into the engine. A by-pass duct permits a part of the intake air to be by-passed around the air compressor and passed in variable proportions either to the engine compressor stages or directly out of a by-pass duct outlet.


With great interest, we have read the study by Loverre et al. The authors show by means of immunostaining that numerous IL-17+CD4+ cells are present in renal biopsies during T-cell-mediated rejection (TCMR) and demonstrate that tubular epithelial cells (TECs) represent a significant source for IL-17 in antibody-mediated rejection (ABMR; Ref. 1). We have some concerns regarding the specificity of the immunostaining.


Abstract Production volumes of advanced high strength steels (AHSS) are growing rapidly due to material and energy savings they provide in a number of application areas. In order to use their potential fully, it is necessary to minimize any danger of unexpected failures caused by hydrogen embrittlement. It is possible only if deeper understanding of underlying mechanisms is obtained through further research. Besides description of main grades of AHSS and mechanisms of HE, this paper reviews available tools for determination of hydrogen content and susceptibility to HE focusing on atmospheric conditions. Techniques such as slow strain rate testing, constant load testing, electrochemical permeation technique, scanning Kelvin probe and scanning Kelvin probe force microscopy have already been used to study the effect of hydrogen entered under atmospheric exposure conditions. Nanoindentation, hydrogen microprint technique, thermal desorption spectroscopy, Ag decoration or secondary ion mass spectrometry can be also conducted after atmospheric exposure.


Lichens are chemically characterized by so-called lichen substances, which include specific secondary compounds only encountered in intact lichens (1). The high concentrations of lichen substances often accumulated (up to 20% of the dry weight) suggest ecological importance for the producing organisms. Various ecological roles have been attributed to lichen substances in the past, including antiherbivore properties (2). In this study, we have focussed on the feeding deterrent and growth retarding activity of various lichens as well as of isolated lichen substances towards larvae of Spodoptera littoralis (Lepidoptera: Noctuidae), a widely distributed pest insect.


Vibrational frequencies of the coupled N-H, C=O stretches (amide I), and C-N stretch/CNH bend (amide II) have been calculated by density functional theory (DFT) at the B3LYP/D95** level and compared for polyglycines in β-strands and chains of H-bonding formamides. The amide groups of the polyglycines are connected by covalent bonds but not by extended H-bonding interactions. Conversely, the H-bonding chains are connected by an extended H-bonding interaction, but not by covalent bonds. All three types of vibrations couple more strongly and are more red (amide I and N-H) or blue shifted (amide II) in the formamide chains than in polyglycine. In contrast to polycglycine chains, the C=O's nearest the center of the formamide are elongated compared to those near the ends. As a result, the C=O's near the center of the chain of 10 formamides no longer couple effectively with the C=O's near the ends. Isotopic substitutions of 1 3 C, 1 4 C, 1 8 O, and 2 H (deuterium) at individual sites allowed us to probe the natural frequencies of individual C=O's and N-H's. The central 1 3 C=O's and 1 4 C=O's of the formamide chains (but not polyglycine) are significantly more shifted than those at the ends from those of a model containing only one C=O. The greatest intensity for the H-bonded C=O's comes from the lowest frequency fully delocalized stretch. 1 4 C isotopic substitution confines the vibrations to either side of the position of substitution, effectively restricting the extent of delocalization and lowering the intensity of the vibration. In general, the vibrations studied couple more effectively through the H-bonds than through the covalent bonds.


The issue of distribution of mineral water in the completion of TSP (Traveling Salesperson Problem) can occur when taking the wrong distributor that takes a long time. Because in the water distribution company with more emphasis on search using the shortest route from the entire route that bypassed by distributor. Determination by the mineral water company should have some alternative solutions that settlement is more effective and efficient in order to optimize distribution. In this case, the use of genetic algorithms can allow companies to determine the shortest route of all the route followed by the distributor. Therefore, if the company distributes mineral water to certain distributors with the provisions of the intended sub-districts of different routes every day. Genetic algorithms in this system find the distance thoroughly and not the distance to be searched, so that the distribution of the mineral water can get to their destination with effective and efficient because it is more focused on the shortest distance of all the paths taken.


Security of attachment ratings were significantly negatively related to indices of fear of strangers and separation distress/protest in 2.5-year-olds (r = − .32 and − .31 respectively, N = 82). With the attachment classifications, significant between-group differences occurred even among the secure groups. Secure-reserved and secure-ambivalent children were significantly more fearful of strangers than very secure children. Secure-ambivalent children showed more intense separation behaviour than very secure and secure-reserved children.

Two groups, one secure (secure-ambivalent) and another insecure (ambivalent), were above the mean of the whole sample on all indices of fear and separation distress/protest, suggesting a particular behavioural 'style' independent of security of attachment. Such a style could reflect an influence of family relationships as well as early appearing temperament.

Correlations between maternal and observer assessments were not significant for security of attachment (r = .11) but were significant for fear of strangers (r = .40). For both relations, significant discrepancies appeared: Mothers of children with secure classifications of attachment (very secure, secure-reserved, secure-ambivalent, and secure-controlling) rated them as both less secure and more fearful of strangers than indicated by corresponding laboratory assessments, while mothers of insecurely attached children (avoidant, ambivalent, and controlling) rated them as more secure and less fearful.


The pressures of conformity within a highly institutionalized organizational field such as corporate and investment banking in the United States are formidable. Coercive, cognitive, and normative pressures often move the herd in the same direction. Paradoxically, each firm believes it is unique and can manage future strategic actions, as it collectively runs off a cliff. This process is not bound in time or space, as researchers grounded in experience have suggested that costly financial bubbles have been common to banking organizational fields in both recent and ancient history. This override of learning may possibly be explained by mutually reinforcing institutional and organizational logics and processes. The author also argues that an awareness of the underlying conformist logics of financial mania, institutional, and configuration theory may explain why some organizations manage to be nonconformist or contrarian. These different firms observe this reliance on powerful multiple logics of conformity and resist them intendedly and unintendedly. The author calls this process contrarianism.


Example embodiments disclosed and interference coordination method in an LTE system, a node device according to the present invention, wherein the interference coordination method in an LTE system, comprising: generating interference coordination message, the interference plurality of resource coordination message includes a source node device the priority of each resource configuration, the priority of the priority preset in the configuration is used as control channel resource or a control message; the interference coordination message to the target node device transmits, to the target node that the apparatus according to the the interference coordination interference coordination message; transmitting to the operator or the management element of the interference coordination message to the operation and management of network element configuring the interference coordination message to the target node device, the target node so that the device interference coordination based on the interference coordination message. According to the present invention, interference coordination can achieve higher efficiency, and to further ensure that the resources for the control channel as a system to prevent interference.


ABSTRACT The 2014 European Parliament elections saw an unprecedented surge of support for Eurosceptic parties. This article provides an overview of the ideologically highly diverse Eurosceptic camp in the European Parliament and addresses the causes and consequences of the Eurosceptic vote. Based on an analysis of aggregate election results and opinion-poll data, it argues that the electoral success of Eurosceptic parties cannot be dismissed as a mere protest vote against unpopular governments. Instead, fundamental worries about the effects of European Union (EU) policies and dissatisfaction with mainstream politics lie at the heart of the Eurosceptic success. The selection of Jean-Claude Juncker as President of the Commission, backed by overwhelming majorities in the European Council and the European Parliament, suggests that Eurosceptics, despite their considerable electoral support, will continue to be excluded from the EU's corridors of power. This strategy of exclusion provides the ideal breeding ground for an even stronger Eurosceptic backlash in five years' time.


Chapter 9 contains papers and essays written by the author after his move from academe to the world of policymaking. The essays straddle some of the same topics as in the previous chapters—India's economic trajectory, India's slowdown and policies to fire up the economy, and the jostling between China and the United States and its fallout for the world. But the essays are now tainted by the author's direct, first-hand experience in the world of politics and policymaking, in New Delhi and Washington, DC. The chapter also contains an analysis of India's demonetization policy.


Symbolic execution is a popular program analysis technique that allows seeking for bugs by reasoning over multiple alternative execution states at once. As the number of states to explore may grow exponentially, a symbolic executor may quickly run out of space. For instance, a memory access to a symbolic address may potentially reference the entire address space, leading to a combinatorial explosion of the possible resulting execution states. To cope with this issue, state‐of‐the‐art executors either concretize symbolic addresses that span memory intervals larger than some threshold or rely on advanced capabilities of modern satisfiability modulo theories solvers. Unfortunately, concretization may result in missing interesting execution states, for example, where a bug arises, while offloading the entire problem to constraint solvers can lead to very large query times. In this article, we first contribute to systematizing knowledge about memory models for symbolic execution, discussing how four mainstream symbolic executors deal with symbolic addresses. We then introduce MemSight, a new approach to symbolic memory that reduces the need for concretization: rather than mapping address instances to data as previous approaches do, our technique maps symbolic address expressions to data, maintaining the possible alternative states resulting from the memory referenced by a symbolic address in a compact, implicit form. Experiments on prominent programs show that MemSight, which we implemented in both Angr and Klee, enables the exploration of states that are unreachable for memory models that perform concretization and provides a performance level comparable with memory models relying on advanced solver theories.


Introduction
Currently, health workers have been living with a high workload, resulting in increased service activities and decreased physical activity, affecting their quality of life. Physical activity is a fundamental aspect of the improvement of motor skills and work performance, allowing a healthy lifestyle.

Objective
To verify the correlation between the quality of life and physical activity of family health support professionals.

Methods
We evaluated 19 professionals aged (31.05±6.63 years) who worked in the three family health support centers (FHSC) of the city of Vitória de Santo Antão. Whoqol-bref and Baecke questionnaires were applied. Data normality was verified from the Shapiro-Wilk test and the Pearson correlation test was performed.

Results
Positive Correlations were found between general score and physical activity during exercise and leisure (r=0, 852; p<0,001) and physical activity at work (r=0,611; p<0.001). There was a positive correlation between the physical domain of quality of life and the general score of habitual physical activity (r=0,520; p<0.05). There was a positive correlation between length of service and physical activity in exercise and leisure (r=-0.649; p<0.001) and physical activity at work (r=-0.559; p<0.05).

Conclusion
The results allow us to conclude that there are positive correlations between activity level and quality of life. The practice of a physical activity is fundamental to the maintenance of work activities. Besides reflecting positively on social aspects.


Thermal imaging has shown potential to assist with many aspects of irrigation management that include scheduling application of water and detecting leaking irrigation canals and delivery systems. There are particular challenges for use of thermal imaging for scheduling irrigation in humid subtropical climates, which include the need for fine delineation of canopy temperatures under low vapor pressure deficits, proper accounting for micrometeorological conditions, and altitude effects on canopy temperature represented at the camera. A review of pertinent issues involved in using thermal methods for sensing canopy temperature is presented that can be applied to the imaging problem. Altitude effects were demonstrated in a new field experiment, and multiple regression was used to indicate and model weather and altitude effects. The use of spatial statistics was shown to enhance the value of thermal imagery using sensor fusion. Thermal imagery was also useful in detecting leakage from irrigation systems in the context of overall irrigation system management.


The traditional approach of Fixed Base Units (FBU) in Unequally Spaced (US) Dense Wavelength Division Multiplexed (DWDM) systems outperforms Equally Spaced (ES)DWDM Systems. Currently in the scenarios of diverse bandwidth requirements for next generation optical communication systems, a novel Dynamic Base Unit (DBU) unequal channel (US) allocation strategy is designed, and the performance benefits are investigated over the traditional existing Fixed Base channel allocations. The proposed algorithm decides the total number of base units covering the optical bandwidth. After the channel allocation in the first base unit $BU_{i=0}$ the current work discusses the case of reducing the number of channels in subsequent Base Unit $(BU_{i=1,2,..})$ by a factor of 2. Moreover, the adjacent base units are allotted even and odd frequency slots. Thus, this is an optimum strategy where maximum non-uniformity is taken care of in channel allocations. This drastically reduces the nonlinear effects of Four Wave Mixing (FWM) prominent in DWDM systems using Dispersion Shifted Fibers. The proposed algorithm is evaluated in terms of the bandwidth occupancy and number of Four Wave Mixing products. Performance up to greater than 34.6% reduction in FWM is observed. Bandwidth occupancy shows 13.7%, 6.25% and 7.45% reduction than the popular Unequally Repeated US(URUS), Paired URUS and Alternately Paired RUS (PURUS) schemes respectively. The high improvement factor is observed when using DBU-US. It is concluded that Dynamic Base Unit-Unequally Spaced channel allocation is superior and is considered a suitable candidate for high speed DWDM transmission systems.


The development of the primary sensory innervation of the superficial dorsal horn (SDH) was studied in postnatal opossums Monodelphis domestica by using DiI labelling of primary afferents and with GSA‐IB4 lectin binding and calcitonin gene‐related peptide (CGRP) immunoreactivity to label primary afferent subpopulations. We also compared the timing of SDH innervation in the cervical and lumbar regions of the spinal cord. The first primary afferent projections to SDH emerge from the most lateral part of the dorsal root entry zone at postnatal day 5 and project around the lateral edge of the SDH toward lamina V. Innervation of the SDH occurs slowly over the second and third postnatal weeks, with the most dorsal aspect becoming populated by mediolaterally oriented varicose fibers before the rest of the dorsoventral thickness of the SDH becomes innervated by fine branching varicose fibers. Labelling with GSA‐IB4 lectin also labelled fibers at the lateral edge of the dorsal horn and SDH at P5, indicating that the GSA‐IB4 is expressed on SDH/lamina V primary afferents at the time when they are making their projections into the spinal cord. In contrast, CGRP‐immunoreactive afferents were not evident until postnatal day 7, when a few short projections into the lateral dorsal horn were observed. These afferents then followed a pattern similar to the development of GSA‐IB4 projects but with a latency of several days. The adult pattern of labelling by GSA‐IB4 is achieved by about postnatal day 20, whereas the adult pattern of CGRP labelling was not seen until postnatal day 30. Electron microscopy revealed a few immature synapses in the region of the developing SDH at postnatal day 10, and processes considered to be precursors of glomerular synapses (and thus of primary afferent origin) were first seen at postnatal day 16 and adopted their definitive appearance between postnatal days 28 and 55. Although structural and functional development of forelimbs of neonatal Monodelphis is more advanced than the hindlimbs, we found little evidence of a significant delay in the invasion of the spinal cord by primary afferents in cervical and lumbar regions. These observations, together with the broadly similar maturational appearance of histological sections of rostral and caudal spinal cord, suggest that, unlike the limbs they innervate, the spinal regions do not exhibit a large rostrocaudal gradient in their maturation. J. Comp. Neurol. 495:37–52, 2006. © 2006 Wiley‐Liss, Inc.


Human detection methods are widely used in various fields such as autonomous vehicles, video surveillance, and rescue systems. To provide a more effective detection system, different types of sensor data (i.e. optics, thermal, and depth data) may be used together as hybrid information. Fortifying object detection, based on optical data and additional sensor data, such as depth and thermal data, also represents information regarding the distance and temperature of classified objects that can be used for video surveillance, rescue systems, and various applications. In this study, a simple and effective method is introduced to fuse RGB-D and thermal sensor data to achieve a more accurate form of human detection. To accurately combine the sensors, they are physically fixed to each other, and the relationship between them is determined using a novel method. The feature points on the optical and thermal images are extracted and matched successfully using computer vision. The proposed method is completely brand-free, easy to implement, and can be used in real-time applications. Using both thermal and optical data, humans are classified as benefiting from a widely used object detection method. The performance of the presented method is tested with a newly generated dataset. The proposed method boosts human detection accuracy by 5% when compared to the use of only optical data and by 37% when compared to the use of thermal data with COCO Dataset upon YOLOv4 neural network weights. After training with the newly generated dataset, the detection accuracy increases by 18% compared with the best results of single sensor usage.


Optimal T cell activation requires both TCR signaling and costimulation through CD28. In vivo use of the drug CTLA4Ig (Abatacept) interrupts B7:CD28 binding and has been an effective therapeutic strategy for chronic inflammatory disease. The presumed mechanism of action of CTLA4Ig is that it prevents the initiation of CD28 signaling. However, previous studies in our laboratory have demonstrated that in a murine model of allergic airway inflammation, CTLA4Ig can function by a novel CD28-independent, NOS2-dependent mechanism. In this study we further dissected this novel mechanism of CTLA4Ig by looking at both in vivo and in vitro models. We now demonstrate through the use of bone marrow chimeras and knockout mice that this in vivo mechanism requires IFNγ and STAT-1 mediated signaling. Furthermore, we used an in vitro coculture system of splenocytes and bone marrow derived macrophages to establish that CTLA4Ig binding to B7 on splenocytes induces IFNγ secretion. This cytokine stimulates the bone marrow derived macrophages to activate STAT-1 dependent NO production, which inhibits T cell proliferation. This data establishes a novel mechanism for immunosuppression by CTLA4Ig. In contrast to accepted dogma, CTLA4Ig inhibits ongoing inflammation not solely by preventing CD28-mediated costimulation, but by a novel mechanism whereby B7 ligation leads to the induction of an IFNγ/STAT1/NO mediated signaling pathway and suppression of T lymphocytes.


Nonreturning students are comprised of several student subpopulations including drop-outs, stop-outs, opt-outs, and transfer-outs. All too often these students groups are not differentiated in retention studies. The current study profiles these student subpopulations, each with varied reasons for discontinuing their studies, and examines the implications of these differences for campus retention strategies.