CONTEXT
Heat treatment allows the use of direct composite resins for fabrication of inlays/onlays restorations because it improves some mechanical and physical properties.

AIM
The aim of this study is to analyze the influence of heat treatment on the water sorption and solubility of direct composite resins compared with an indirect composite resin.

MATERIALS AND METHODS
A total of 50 cylindrical specimens were fabricated (6 mm diameter × 2 mm high) and divided into five groups (n = 10): G1 (FillMagic without heat treatment-control 1), G2 (heat-treated FillMagic), G3 (P60 without heat treatment-control 1), G4 (heat-treated P60) and G5 (indirect resin Epricord-control 2). After fabrication, the specimens were placed in a desiccator containing silica gel and maintained at 37°C for 24 h. This cycle was repeated until a constant weight was achieved (m1). Following, the specimens were stored in individual flasks containing 2 ml of distilled water in an oven at 37°C. The specimens were weighed after intervals of 1, 7 and 21 days of immersion in water (m2). After 21 days of storage in water, the specimens were once again desiccated until a constant weight was achieved (m3). The mean diameter and thickness of specimens were obtained using a digital pachymeter.

STATISTICAL ANALYSIS USED
Two - way analysis of variance and Tukey's test were used to compare the sorption and solubility (α = 0.05).

RESULTS
The type of resin significantly influenced the sorption (P = 0.01) and solubility (P = 0.00). The heat treatment also significantly influenced the sorption (P = 0.026) and solubility (P = 0.01).

CONCLUSION
It was concluded that the heat treatment is an additional curing method that improves strength to the sorption and solubility of composite resins.


Background Presently, no study reported the function of cathepsin H (CTSH) in thyroid carcinoma (THCA). The aim of present study was to initially explore the factors affecting CTSH expression, and association between CTSH expression and survival rate in THCA. Methods We explored mRNA expression of CTSH in normal and BRCA tissues, and evaluated prognostic impact of CTSH expression on the overall survival of THCA patients. Then, related factors influencing CTSH mRNA expression in THCA were analyzed. Functional enrichment analysis was performed to reveal the potential function of CTSH involved in THCA. We also constructed PPI network among co-expressed genes of CTSH to determine hub genes, followed by association analysis on hub genes with CTSH. Results (1) CTSH mRNA was highly expressed in THCA compared with normal group (P<0.001). High expression of CTSH was conducive to the overall survival of THCA patients (P=0.0027). CTSH was then determined as an independent prognostic factor in THCA (P=0.024). (2) The mRNA expression of CTSH was statistically related to patient's histological type, N stage, T stage, tumor stage and sample type (all P<0.001). CTSH copy number variation and methylation also influenced its mRNA expression (all P<0.001). (3) Pathway analysis indicated that CTSH mainly participated in cancer-related pathways, such as hedgehog signaling pathway, cytokine–cytokine receptor interaction and JAK-STAT signaling pathway (all P<0.05). (4) The top 10 co-expressed genes in whole PPI network showed significant correlation with CTSH expression (all P<0.001). Conclusion CTSH higher expression was observed in THCA, which caused a good prognosis of patients. CTSH expression might be regulated by multiple factors including clinical characteristic, methylation, copy number and other genes. This study demonstrated the clinical significance of CTSH in THCA, as well as revealed the potential pathway associated with CTSH involved in thyroid cancer.


Objective To establish an animal model of cervical spondylotic myelopathy( CSM) with typical clinical characteristics through bone cement compression nail in order to investigate the pathological changes of cervical spondylotic myelopathy and the changes in CT and MRI examination. Methods Twenty-five New Zealand white rabbits( 12-week age)were divided into two groups,experimental group( n = 20) and control group( n = 5). Before operation all the animals underwent somatosensory evoked potential( SEP) examination and motor function scoring. A bone cement compression nail was placed in front of C3 centrum of rabbits in experimental group. After operation the changes of nerve function were observed for6 months,and SEP,CT imaging,MRI imaging were performed. Results The nerve symptoms appeared firstly during 3 months after operation and motor function showed obvious differences at 6 months after operation. The significant changes were found in amplitude and incubation period of SEP in experimental group( P 0. 05). The location of bone cement compression nail could be observed in sagittal view and axial view of CT in experimental group,with average vertebral canal occupying rate being40. 2%. The spinal compression was observed in axial view image of MRI,with average spinal compression rate being 43. 9%in experimental group,moreover,the signal intensity in compression area in T2 weighing sagittal view was obviously higher than that in non- compression area. Pathological examination showed that substantia grisea medullae spinaliskwtl anterior horn was flatten in experimental group,cornu anterius medullae spinalis cells were disappeared or necrosis,substantia alba medullae spinalis presented vacuole change,with axonal degeneration and slight demyelination changes,Furthermore substantia grisea medullae spinaliskwtl slight gliosis could be observed. Conclusion The animal model with cervical spondylotic myelopathy established by bone cement compression nail has typical clinical characteristics,which can be used in pathological examination,SEP,CT,MRI inspection,with simple making,good repeatability,which is a reliable model for researching related data of cervical spondylotic myelopathy.


We report a first\|principles local density approximation band structure calculation on the electronic structure of high\| T C superconductor MgB\-2.It is revealed that the band structure of magnesium diboride is of metallic type with a wide valence band.The density of states of electrons at Fermi energy is only about 0.72 (states/eV).We conclude that the present calculation excludes the possibility of BCS mechanism in MgB\-2.


Multilayer adsorption theory is used to derive an equation that accurately fits the experimental isotherms for the whole range of adsorbate concentration. The parameters used in the proposed isotherm equation relate to the size and fraction of capillaries and pores in the adsorbent material. A relationship between the change in the quantity of adsorbed molecules and temperature is derived for any adsorbent material in which the sizes of capillaries and pores do not change with temperature. This equation, when combined with the isotherm equation, produces a family of isotherms at varying temperatures, and the isosteres for changes in regain with temperature at constant humidity. From the absorption behavior of wool at high temperature, the steady-state condition during steaming of wool can be predicted. For the conditions that prevail in pressure decatizing, fabric with initial regains in the range of 13-18% will take the least time to reach equilibrium.


The electron-paramagnetic-resonance spectrum of Np/sup 4 +/ diluted in CsZrCl/sub 6/ is analyzed in terms of the theory formulated by Belorizky et al. It is shown that if g/sub J/, the Lande g factor, is allowed to vary freely, a satisfactory fit may be obtained which is consistent with optical and EPR data obtained earlier on other tetrapositive actinide ions in the same host crystal. It is suggested that a better fit between the experimental data and the calculated spectrum may be obtained if the Zeeman mixing between the ground GAMMA/sub 8/ state and the excited GAMMA/sub 6/ state is considered.


BACKGROUND
The goal of the current study was to assess the usefulness, reliability and safety of the imageguided stereotactic biopsy of intra-axial brain tumours.
METHODS
The study was conducted within a time frame of one year. 20 patients – 14 males and 6females (median age 63.5 years) were included. Computerized tomography (CT) – guidedstereotactic biopsies were performed by a single stereotactic neurosurgeon. A modifiedRiechert Stereotactic System (MHT Medical High Tech) and a workstation for multiplanartrajectory planning (Amira) were used. Biopsies were done with small forceps and 10–15samples were collected for histological analysis. During the operations also touch imprints and crush smears of the specimens were examined by the cytopathologist. Correct place ofthe biopsy and any detectable bleeding were analyzed by post-op CT scan. Descriptivestatistic methods were used and results were compared with the data from the literature.
RESULTS
Overall treatment morbidity was limited to one patient (5 %), there was no mortality.A conclusive tissue diagnosis could be achieved in 19 out of 20 patients (95 %). There were3 glioblastomas, 3 anaplastic astrocitomas, 5 astrocitomas, 1 inflammation, 2 lymphomas,and 2 malignant tumours – not further classified and 3 metastasis. All patients had postbiopsy CT scan to check for haemorrhage (none occurred).
CONCLUSIONS
MHT Stereotactic system and Amira multiplanar image guided trajectory planningsoftware are reliable tools enabling trained stereotactic neurosurgeon to obtain tissuediagnosis in almost every case with very little morbidity


Abstract We present a result of the molecular dynamics calculations with used a three-body empirical Tersoff potential. The parameters of the Tersoff potential are determined for nitride compound semiconductors such as GaN, AlN and InN. The structural and thermodynamic properties of GaN, AlN and InN in zinc-blende structure are presented. We report the equilibrium lattice constants, the bulk moduli, the cubic clastic constants, thermal expansion coefficient and specific heat. Good agreement is obtained with recent experimental and theoretical results for all constants.


For many companies and institutions, the supply chain model for reliability & maintainability (R&M) of systems can either act as their competitive advantage or weakest link. Big data and analytics play an instrumental role within the supply chain, especially for companies using R&M principles, where these practices were born and matured. The automotive industry has led many initiatives to increase the adoption of such supply chain architectures within their vehicle ecosystems allowing big data and analytics to play the driving role to insure the performance of the vehicles. The automotive industry continues to use these practices to deal with disruptions within autonomous driving, self-healing efficient batteries, robotics, insurance risk assessments, and exceptional customer experiences. Whether it be automotive manufacturers, dealers, drivers, or insurance companies, R&M have had positive results. Today, however, another technology is surfacing fast, changing the face of R&M standard practices and applications. Artificial Intelligence (AI) is impacting and changing the entire automotive industry ecosystem. While advancements in chipsets, edge technology, 5th generation mobile network (5G), Internet of Things (IoT) and cloud have been acting as enablers, data and AI is at the heart of R&M future advances. As per VynZ Research, Global Artificial Intelligence (AI) Market for Automotive and Transportation Industry is Set to Reach USD 45.1 billion by 2024, Observing a CAGR of 17.7% during 2019–2024 [1].In this paper, we will share the impact of AI & trust on the auto industries R&M programs, broken down across four pillars: in-vehicle experience, connected vehicles, auto manufacturing, and autonomous vehicle with examples, and use-cases.


It is proposed that, within the population of M-form firms, the control systems necessary to realize economic benefits from interrelationships between subunits o f a firm are incompatible with the systems necessary to realize benef its from an M-form type internal capital market. This hypothesis is t ested on 156 large U.K. firms. Questionnaire data are used to classif y the firms according to their internal control characteristics. The findings provide tentative support for the hypothesis. Copyright 1988 by Blackwell Publishing Ltd.


"Congratulations! Sony Pictures producers have hired you as a scientific consultant to assist them in producing a remake of the classic film Gone With The Seabreeze, which chronicles the founding of the Westchester campus of Loyola University in 1929. The original film features shots of various old buildings that can still be found across campus today. The producers wish to recreate these shots, but need to know where to position the camera, which they have tasked you with finding." Thus began the month-long, collaborative project at Loyola Marymount University between the honors underclassmen in HNRS 140, On Motion and Mechanics, taught by Alissa S. Crans, and the senior applied mathematics majors in MATH 495, Mathematical Modeling, taught by Robert Rovetti. During a period of four weeks, six teams of freshman and sophomore liberal arts honors students, each led by a senior math major, set out to reconstruct an old photograph using a mathematical technique based on straightforward geometry. Along the way they would run into inaccessible landscapes, blocked views, and busy schedules, but ultimately they emerged with both a finished product and a clearer understanding of what it means to apply a theoretical method to a real-world problem. We begin by describing the courses and the assigned project itself, and then we reflect on the pedagogical goals of the project and various observations made by both students and instructors. DESCRIPTION OF COURSES On Motion and Mechanics (HNRS 140) offers freshman and sophomore honors students outside of LMU's Seaver College of Science and Engineering the opportunity to experience the methods, practices, and techniques common to science, mathematics, and engineering disciplines. While the name of the course does not change, the content each year depends entirely on the instructor. In the past few years, this course has been taught by faculty members in the fields of engineering and natural science who focused on comparing and contrasting scientific and engineering methods and then climate change and environmental issues. This past fall, however, the course was structured around the dual questions "What is mathematics?" and "What do mathematicians do?" Throughout the semester we discussed questions such as "What does it mean to perform research in mathematics? Is mathematics created or discovered? Where, and by whom, is mathematics used and practiced?" and "How is mathematics similar to and different from the humanities, sciences, and engineering?" our reading list was extensive and included Steven Strogatz's "Elements of Math" column from the New York Times website, How Mathematicians Think by William Byers, biographies of mathematicians from the undergraduate mathematics journal Math Horizons (published by the Mathematical Association of America), essays from Campbell and Higgins' Mathematics: People, Problems, Results, entries on the website weusemath.org, and A Mathematician's Apology, by G. H. Hardy. We also watched video presentations by mathematical speakers on the website TED.com and attended the Einstein Public Lecture in Mathematics given by Fields Medalist Terrance Tao at UCLA. In addition to the project described in this paper, the students completed group projects on graph complexity, voting paradoxes, and statistics. The major assignment for the course consisted of a paper about a mathematical topic together with an in-class presentation. Topics included the Monty Hall Problem, knot theory, game theory, Lewis Carroll logic problems, the golden ratio, check digits, and infinity, among others. In contrast, Mathematical Modeling (MATH 495) is a course designed specifically for students in the College of Science and Engineering. It provides senior applied mathematics majors with a capstone experience through activities that bring together the material and skills they have acquired during their undergraduate training. Students are exposed to classic problems in modeling and are encouraged to use a variety of techniques, both analytical and computational, to solve them. …


SUMMARY Perceptions of self-injurious behaviour as refractory to treatment, and of treatment outcomes as unpredictable, in children and adults with intellectual disabilities and/or autism may lead to treatment inertia or nihilism, restrictive practices and overuse of psychotropic medication in its management. Recent research suggests, however, that from infancy to young adulthood prospects for a positive outcome are fair, and markers predictive of treatment outcome have begun to be identified. In this clinical reflection we briefly describe this work, consider how it may contribute to case stratification, and outline current thinking on further functional differentiation of cases of SIB, promoting non-restrictive practices.


(57) Abstract: apparatus for accessing in the field devices in a distributed control system provides a non-redundant secondary access to a plurality of field devices that are controlled by the control room. The apparatus also provides a redundant wireless access to in field devices in a distributed control system having a main access to the field devices provided by the hard-wired media that couples the field device to the control room. Field devices are coupled to a field bus control network. In a first embodiment, each field device includes an accessible wireless Fieldbus port by a wireless handheld unit or a wireless terminal. Field module in the second embodiment, each Fieldbus control network, with all the devices connected to the fieldbus control network, a wireless Fieldbus port that allows it to be accessed by the wireless handheld unit or a wireless terminal It is equipped with a. Third In embodiments, H2-to-H1 Fieldbus bridge (which services as a plurality of H1 control networks), all of the field devices connected to H1 control networks serviced by the H2-to-H1 bridge but to allow being accessed by a wireless hand held unit of the wireless terminal. In a fourth embodiment, the bridge / converter provides an interface between the old analog control chamber component with a new Fieldbus devices. In one configuration, the bridge / converter comprises a hardwired Fieldbus port connected to the terminal, this may be placed in the control room. In other configurations, the bridge / converter includes a wireless Fieldbus port that allows the wireless handheld unit or a wireless terminal to access the fieldbus devices served by a bridge / converter. The present invention allows the maintenance personnel to access the field bus the field device while operating the device in the field and then, the secondary function of the field devices (depending skill) is accessed from a single remote unit the possibility to be. Redundant wireless access provided by the present invention, the operator of the control chamber, when the event defective hardwired media providing primary access to the field device is not caused or utilized to access the field devices possible to be.


Summary The material investigated in 2009–2011 were 203 samples of maize grain. The aim of the study was to evaluate the content of the mycotoxins: deoxynivalenol (DON), nivalenol (NIV), T-2 toxin, HT-2 toxin, zearalenone (ZEA) and fumonisins (FUM) using a high performance liquid chromatography (HPLC) with MS/MS (tandem mass spectrometry) detection and mycological analysis of selected samples. Identified species of fungi confirmed that the maize grain was dominated by moulds of the toxicogenic potential. All the analyzed samples revealed the presence of Fusarium mycotoxins with varying level in each year of the study.


The most important condition for functioning of all living aerobic organisms is continuous supply of sufficient oxygen. The access of oxygen to metabolic processes in cells is mediated by the respiratory proteins, tetrameric blood hemoglobin (Hb) and monomeric muscle myoglobin (Mb). Myoglobin is expressed in red muscles in response to mitochondrial demand for oxygen, transporting it from sarcolemma to mitochondria [1-3]. Particularly high Mb concentration is observed in muscles of aquatic mammals, who spend a long time underwater for food, and also in those of highland animals, living under deficient O2, which served as the basis for the hypothesis that myoglobin is the "oxygen store" for mitochondrial cytochrome c oxidase.


Computer Generated Hologram (CGH) is generated by computer simulation using the diffraction theory. However, the development of a rendering technology to display images beautifully like in the field of Computer Graphics is scarce. The research for reflectance distribution is particularly so few, that the texture of each material cannot be expressed. Therefore we propose a calculation method for calculating reflectance distribution for CGH that uses the finite-difference time-domain (FDTD) method. In this method, reflected light from an uneven surface made in the computer is analyzed by FDTD simulation, and a reflected light distribution is applied to CGH as object light. To make the outer structure identical to the real objects, the outer structure of the real objects was measured with an atomic force microscope (AFM). By using the measurement data, peculiar reflectance distributions of the materials are given for CGH. It was confirmed that the variation of the surface roughness of the measured sample affected the three-dimensional images in optical reconstruction. Moreover, we report the relation between the surface roughness of samples and the reflectance distribution.


Great attention should be well paid to the personality in teaching. Personality is the aim of teaching as well as method. Personality is an idea or spirit. Personality of both teacher and student should be respected in teaching, which embodies protection of spirit and allowance of personality.


The effects of acetate and propionate in enhancing intramuscular fat (marbling) deposition in beef cattle are poorly understood. This study aimed to evaluate the effects of acetate and propionate on pre-adipocyte determination and adipocyte differentiation in stromal vascular cells (SVC) isolated from the intramuscular tissue of Hanwoo beef cattle. SVC were isolated and treated with different concentrations of acetate and propionate (0.125 to 1 mM). Pre-adipocyte determination was observed through the Zfp423 (Zinc finger protein 423) and Pref-1 (Pre-adipocyte factor-1) genes expressions, which were important transcription factors used to identify committed pre-adipocytes. Adipocyte differentiation was determined based on the lipid accumulation, triglyceride contents, and their molecular activities related to adipogenic markers. The results suggest that acetate supports pre-adipocyte determination in SVC which is observed to increase the expression of Zfp423 and Pref-1 along with the increasing acetate concentration. Propionate treatment was seen to significantly affect lipid accumulation as well as triglyceride content in SVC, compared to acetate treatment. Furthermore, propionate treatment very significantly increased the expressions of PPARγ, C/EBPα, SREBP-1c, and FABP4. In conclusion, acetate likely enhances pre-adipocyte determination, while propionate effectively promotes adipogenesis in SVC isolated from the intramuscular tissue of Hanwoo beef cattle.


Turbo-generator stator's inter-turn short is a usual serious fault, there would have hidden big trouble for electric power system's safety due to lack of efficient protection. On-line monitoring generator's operate condition combined intelligence non-line identify technology is presented to observe fault in time instead of poor function of protection. Longitudinal zero-sequence voltage and fault phase's current are analysis as stator winding's inter-turn short's stable fault characters, mathematical model of which are build, Elman neural network which do well for dynamic data in real time are introduced to identify the fault. A large turbo-generator's general parameters are used for calculate its stable fault characters during stator winding's inter-turn short occur in operation, and identification are performed by trained Elman neural network followed. Example indicate that the Elman network could efficiently identify generator stator's inter-turn short based on rational fault characters combine.


The Marston Science Library (MSL) at the University of Florida (UF) has compiled a diverse tool library equipped with tech tools and hand tools for check-out to any UF student and use at either the library or outside locations. The objective of this collection is to foster a sense of self sufficiency and sustainability among its primary users, science and engineering students. The intent is to cultivate an active learning environment and a new community of practice within the library through access to tools. As a trial of this new service, MSL made the following tools available for a 1-week check-out: computer repair kits, multimeters, precision screwdriver sets, soldering kits, digital calipers, laser levels, Dremel rotary tool kits, hand drills and bits, and homeowner tool kits. The tools are housed in rolling tools carts and are cataloged for check-out at the library service desk. Promotion for the new tool library included in-library displays, featuring on the library's homepage, printed book marks, and articles in the university newspaper. LibGuides were developed to provide instructions, safety protocols, and links to how-to videos and other instructional online resources and hands-on demonstrations were offered throughout the semester. A preliminary assessment of tool check-outs was conducted, the results of which identified the strengths of the tool-library forum, as well as opportunities for improvement. This paper accompanies a poster presented at the 2019 American Society for Engineering Education conference in Tampa, Florida and provides a discussion of the onesemester trial of the tool library at UF. Background/Literature Review Tool libraries work just like regular libraries but instead of loaning books to patrons, they loan tools. Tool libraries have existed in the U.S. for over 50 years1, with the first tool lending library founded in Columbus, Ohio in 1976.2 One of the oldest and largest tool libraries is in Berkeley, California at the public library, which started in 1979 and has over 3,500 tools available for check-out.3 Some tool libraries missions are to rebuild communities struck by natural disasters. Other tool libraries were established to support community endeavors such as neighborhood redevelopment and community gardens.4 Research has shown that there is an interest in a "Library of Things" and that patrons want access to items and workshops for their use.5 As a large public university, UF has an enrollment of around 55,000 students, of which some 10,000 are associated with the 9 departments, 15 degree programs, and 20 centers and institutes within the Herbert Wertheim College of Engineering. About two-thirds of the engineering students are undergraduates and all are required to have a laptop computer.6 Students' devices, whether laptops, smartphones, wearables, or tablets, experience a significant amount of wear-and-tear and require maintenance and repair. Students often ask the MSL staff about the availability of tools that students may use to repair personal technology devices, and to create objects for class, home, or research projects. To meet this need, MSL used endowment


The ever-increasing availability of online data and the advances of today's Web have enabled large-scale experimentation on data crowdsourcing and the effect of the individual on information extraction and knowledge generation. Tiger Nation, a project to promote preservation of the last remaining wild tigers in the world, utilises advanced technologies to unobtrusively track tigers and raise awareness as a participatory sensing exemplar. Through a tiger stripe recognition algorithm and gamification elements that complement the identification process, we have achieved higher levels of accuracy compared to the conventional means, as well as high levels of engagement from the community of users.


What to expect after a year in space Space is the final frontier for understanding how extreme environments affect human physiology. Following twin astronauts, one of which spent a year-long mission on the International Space Station, Garrett-Bakelman et al. examined molecular and physiological traits that may be affected by time in space (see the Perspective by Löbrich and Jeggo). Sequencing the components of whole blood revealed that the length of telomeres, which is important to maintain in dividing cells and may be related to human aging, changed substantially during space flight and again upon return to Earth. Coupled with changes in DNA methylation in immune cells and cardiovascular and cognitive effects, this study provides a basis to assess the hazards of long-term space habitation. Science, this issue p. eaau8650; see also p. 127 An integrated analysis reveals the changes, down to the molecular level, in one man during a year-long spaceflight. INTRODUCTION To date, 559 humans have been flown into space, but long-duration (>300 days) missions are rare (n = 8 total). Long-duration missions that will take humans to Mars and beyond are planned by public and private entities for the 2020s and 2030s; therefore, comprehensive studies are needed now to assess the impact of long-duration spaceflight on the human body, brain, and overall physiology. The space environment is made harsh and challenging by multiple factors, including confinement, isolation, and exposure to environmental stressors such as microgravity, radiation, and noise. The selection of one of a pair of monozygotic (identical) twin astronauts for NASA's first 1-year mission enabled us to compare the impact of the spaceflight environment on one twin to the simultaneous impact of the Earth environment on a genetically matched subject. RATIONALE The known impacts of the spaceflight environment on human health and performance, physiology, and cellular and molecular processes are numerous and include bone density loss, effects on cognitive performance, microbial shifts, and alterations in gene regulation. However, previous studies collected very limited data, did not integrate simultaneous effects on multiple systems and data types in the same subject, or were restricted to 6-month missions. Measurement of the same variables in an astronaut on a year-long mission and in his Earth-bound twin indicated the biological measures that might be used to determine the effects of spaceflight. Presented here is an integrated longitudinal, multidimensional description of the effects of a 340-day mission onboard the International Space Station. RESULTS Physiological, telomeric, transcriptomic, epigenetic, proteomic, metabolomic, immune, microbiomic, cardiovascular, vision-related, and cognitive data were collected over 25 months. Some biological functions were not significantly affected by spaceflight, including the immune response (T cell receptor repertoire) to the first test of a vaccination in flight. However, significant changes in multiple data types were observed in association with the spaceflight period; the majority of these eventually returned to a preflight state within the time period of the study. These included changes in telomere length, gene regulation measured in both epigenetic and transcriptional data, gut microbiome composition, body weight, carotid artery dimensions, subfoveal choroidal thickness and peripapillary total retinal thickness, and serum metabolites. In addition, some factors were significantly affected by the stress of returning to Earth, including inflammation cytokines and immune response gene networks, as well as cognitive performance. For a few measures, persistent changes were observed even after 6 months on Earth, including some genes' expression levels, increased DNA damage from chromosomal inversions, increased numbers of short telomeres, and attenuated cognitive function. CONCLUSION Given that the majority of the biological and human health variables remained stable, or returned to baseline, after a 340-day space mission, these data suggest that human health can be mostly sustained over this duration of spaceflight. The persistence of the molecular changes (e.g., gene expression) and the extrapolation of the identified risk factors for longer missions (>1 year) remain estimates and should be demonstrated with these measures in future astronauts. Finally, changes described in this study highlight pathways and mechanisms that may be vulnerable to spaceflight and may require safeguards for longer space missions; thus, they serve as a guide for targeted countermeasures or monitoring during future missions. Multidimensional, longitudinal assays of the NASA Twins Study. (Left and middle) Genetically identical twin subjects (ground and flight) were characterized across 10 generalized biomedical modalities before (preflight), during (inflight), and after flight (postflight) for a total of 25 months (circles indicate time points at which data were collected). (Right) Data were integrated to guide biomedical metrics across various "-omes" for future missions (concentric circles indicate, from inner to outer, cytokines, proteome, transcriptome, and methylome). To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress–related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.


Based on the concept of free energy, we give a Hamiltonian formulation for the torsion dynamics of macromolecules. The appropriate reaction coordinates for the free energy calculations are deened in terms of soft constraints as introduced in 3] and 14]. We consider a few simpliications that allow one to calculate the free energy analytically and to write the corresponding equations of motion as a constrained Hamiltonian system. We also discuss a possible stochastic embedding of the reduced dynamics by means of a generalized Langevin approach.


In order to monitor ablation dynamics at the fiber tip in contact Ho:YAG laser ablation, we studied a simple probe method in vitro. The He-Ne laser wasdelivered through a single silica glass fiber with Ho:YAG laser for ablation.The time-history of the back-scatterimg probe light which was produced by the cavity at the fiber tip was measured at the laser incident end of the fiber. From experiments using water and agar as an ablation target, the decay time of backscattering waveform corresponded to the theoretical cavity collapse time. The decay time was also influenced by the viscosity of materials surrounding ablation crater. We measured various human vascular tissues. They were normal aorta wall, fatty atheromatous plaque, and calcified plaque. The decaytime of the waveforms observed from each vascular were different. In the case of soft tissues, the decaytime for normal aorta wall was 13.7ms, and for fatty atheromatous plaque was 5.0ms. This difference seems to be influenced by their viscosity difference. In the case of the calcified plaque measurement, the waveforms were completely different from that of soft tissues. This waveform may be attributed to intensive emission from laser induced plasma. As a result of these experiments, the decay times of the probe backscattering waveforms could discriminate each vascular tissue. Our probe method should be very practical method for preventing vascular perforation during Ho:YAG laser angioplasty. 緒言 レーザー血管形成術開発における最大の 課題は、術中の血管穿孔の防止である。一般に 動脈内レーザー手術では水中接触照射法が主用 されているが、この照射法では蒸散の進行につ れてファイバー先端が組織 、 先端での蒸散状態が把握出来ない。血管穿孔防 止のためにはファイバー先端での状態の把握が 必 要 とな る。 この 目的 の ため に種 々 の経 フ ァイ バ ー的光 学 計測 法 が提 案 され てい る(1)(2)。 し か し、in vivoで 実 用 的 な計 測法 が確 立 され てい る と は言 い 難 い。 一方 、波 長2.1μmの 中赤 外 パ ル ス Ho:YAGレ ー ザ ー は、石 英 フ ァイバ ー で伝 送 が 可 能 で、硬 ・軟 両方 の 動脈 硬化 病 変 を蒸 散 で きるこ とか ら、血 管 形成 術 用 レーザ ー と して


Excerpt To the editor: I read with interest the report of a possible pathogenic relation between monoclonal gammopathy and hereditary spherocytosis (Ann Intern Med88:45-46, 1978). The proposal by S...


OBJECTIVE
This meta-analysis aimed to analyze the efficacy of sorafenib in combination with transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).

MATERIALS AND METHODS
Electronic data bases were searched for studies (1) enrolled HCC patients undergoing TACE; (2) with sorafenib therapy and control arm of no sorafenib therapy were included for meta-analysis and meta-regression; (3) studies without control arm were included for data review and (4) had time to progression (TTP) and overall survival (OS) or relative outcome of HCC as the endpoint. Meta-analysis and meta-regression were performed according to Cochrane guidelines.

RESULTS
Five studies (3 randomized trials, 1 cohort study and 1 prospective non- randomized controlled trial, totally 899 patients) were eligible for meta-analysis. The hazard ratio (HR) for TTP was 0.75 (95% CI: 0.48-1.03, p = 0.003) with significant heterogeneity (I2 = 82.7%) and for OS was 0.76 (95% CI: 0.47-1.05, p = 0.147) with slight heterogeneity (I2 = 47.9%). However, no covariate was found as independent predictor for better treatment efficacy. Hand-foot skin reaction, alopecia, rash/desquamation, diarrhea, hypertension, fatigue, anorexia, nausea and vomiting were common adverse events.

CONCLUSIONS
TACE combined with sorafenib has potential efficacy for HCC.


We experimentally demonstrate that the addition of partial lattice disorder to a thin-film microcrystalline silicon photonic crystal results in the controlled spectral broadening of its absorption peaks to form quasi resonances: increasing light trapping over a wide bandwidth while also reducing sensitivity to the angle of incident radiation. Accurate finite-difference time-domain simulations are used to design the active-layer photonic crystal so as to maximize the number of its absorption resonances over the broadband interval where microcrystalline silicon is weakly absorbing before lattice disorder augmented with fabrication-induced imperfections is applied to further boost performance. Such a design strategy may find practical use for increasing the efficiency of thin-film silicon photovoltaics.


The privatisation of economic infrastructure in Australia that began in the 1980s has continued to be actively pursued by state and federal governments. Evaluations of the effects of the change of policy, ownership, control and regulatory arrangements that have accompanied privatisation and their impact on the longer-term stock of infrastructure and the growth of the economy have received less attention than the immediate privatisation decisions. This article reviews some of the studies that have been carried out to evaluate the impact of privatisation, focusing on long-term impacts on infrastructure provision. In particular, it discusses the myopia created by the emphasis on commercial transactions and managing markets that continues to shape the debate about the provision of infrastructure to meet Australia's economic, environmental and other objectives. Objectives have become even more difficult to achieve as an increasingly extensive and complex regulatory framework is required to manage privatised activities. This adds to costs and limits the potential for the introduction of new initiatives to address pressing problems. The issue is increasingly relevant, given the current perceived shortage of infrastructure and the flow-on effects of the current international financial crisis on Australia. The slow-down in economic growth accompanying the financial crisis is putting pressure on government budgets and threatening to perpetuate the existing policy bias towards short-term solutions, exacerbating the longer run problem of ensuring an adequate supply of public economic infrastructure.


The Purpose of the study was to find out the effect of Suryanamaskar training on flexibility of Cricket players. For the present study total 25 Cricket players were selected from GGV Bilaspur (C.G.) the age of the subjects were ranging from 20 24 years. The variables selected for the present study were Suryanamaskar training (independent variable) and flexibility (dependent variables).The flexibility data was collected through the pre and posttest. For the study single group design was used in which the pretest was taken prior to the Suryanamaskar training and posttest was taken after Eight weeks of Suryanamaskar training. For comparing pre and posttest means of flexibility, descriptive analysis and paired t-test were applied at 0.05 level of significant. The result of the study showed that there was significant difference between pre and posttest flexibility of Cricket players (t=6.713, p<0.05). On the basis of the findings it was concluded that the Suryanamaskar training may be effective for the improvement of flexibility of Cricket players.


Schumpeter tried to develop a theory of endogenous economic change drived by innovation.The evolutionary NeoSchumpeterian used biological analogies for reference to construct behavior model of the firm. They endogenize innvation and analogize natural selection in biology to describe economic dynamic process based on innovation. Neoclassical Schumpeterian growth theory deals with Schumpeter's creative destruction in model and introduces production function of RD and the organization of innovation making technological innovation endogenous. It studies deeply economic structural issues related to economic growth. The differences in methodology and academic tradition among these three streams of theories lead to different understanding of innovation mechanism and economic change. This article systematizes the main development of Schumpeterian economic theory and provides comparison, comment and prospect of the three streams of theories.


With the rapid development of media environment and contents production technology, the era of multi-platform convergence transmedia has emerged, and communication method through trans media contents has attracted attention. Transmedia content refers to the concept of translating individual content into multi-platforms, which creates an expanded worldview of convergence. In addition, the interaction generated in this process is very important and difficult to control in the progress of the content. In this paper, we focused on the combination of transmedia content and gamification concept as a solution, and based on the 'MDA framework' which is a theoretical system of analysis and approach for implementing game design, We looked at the structure. It is expected that a review of the fundamental game design structure, which establishes a prediction system of value and fun experiences through the balance of technology and emotions, will be helpful as a basis for designing trans media contents.


The buckling behaviour of axially loaded high-strength steel (HSS) columns has been researched to extend the scope of design codes to cover higher strength steels. However, intended and unintended load eccentricity will induce bending combined with axial compression in columns. The design of HSS columns in bending and axial compression is limited due to a lack of test data and good understanding. This paper presents an experimental and numerical study on the ultimate strength of HSS columns subject to eccentric compression. Seven Q460C steel welded box-section columns with width-to-thickness ratio of 18, 12 and 8 were tested to failure. A comparison of the test strength with the design strength predicted according to current Chinese and European codes showed the conservatism of the design interaction formulae. A finite-element model with consideration of initial geometric imperfection and residual stress was developed and verified against the test results. Extensive parametric analyses were conducted to i...


The invention relates to a method of making kirsch, especially a method of using cherries as raw material to make the kirsch by the techniques of fermenting and distilling-back fragrance. It adopts the distilling-back fragrance technique for making the kirsch for the first time, improves natural fruital flavor of the kirsch and makes the kirsch with strong fruity flavor and vivid color.


Infrastructure development with focus on water supply system management has assumed significant importance in the recent past in India, and in this endeavour attempts are being made to provide 24 hours continuous safe water supply to the consumers. The important three elements of any water supply system augmentation include: population projection, per capita water needs for full satisfaction and the financial out lay. We address, in this paper, application of fuzzy logic based to project the future water needs. Ever increasing pollution levels due to rapid urbanization and industrialization, especially in developing countries with minimal focus on adequate pollution abatement strategies, result in impairing natural environment such as river, air, land, and alike. Protection of drinking water resources for public water supplies, therefore, assumed vital significance in the context of present times. The practice in vogue of classifying water quality for variety of usage is by computing water quality indices [2]. Why compute a numeric water quality index, and then describe water quality? Why not apply describe water quality, for the defined usage, straightway in linguistic terms with some degree of certainty attached to each linguistic description? In this paper, we present two need based research studies: First case study relates to the estimation of per capita water needs for full satisfaction of the consumers in (Pimpri Chinchwad Municipal Corporation (PCMC - city with a population of 1.8 million) area, India, while the second study refers to fuzzy description of raw water quality near the intake of PCMC war treatment facility.


This paper presents an adaptive QR decomposition (QRD) processor for five-band carrier-aggregated Long Term Evolution-Advanced downlinks. The design uses time and frequency correlation properties of wireless channels to reduce QRD computations while maintaining an uncoded bit error rate loss below 1 dB. An analysis on the performance of a linear interpolating QRD is presented, and optimum distances for different channel conditions are suggested. The Householder transform suited for spatially correlated scenarios is chosen and modified for concurrent vector rotations resulting in high throughput. Based on these, a parallel hardware architecture suitable for easy reconfigurability and low power is developed and fabricated in 28-nm fully depleted silicon-on-insulator technology. The QRD unit occupies 205k gates of logic and has a maximum throughput of 22 MQRD/s while consuming 29 mW of power. On a circuit level, the back gate feature is leveraged to double operational frequency in low time-frequency correlation channels or to lower power consumption to 1.9 mW in favorable conditions. The proposed system provides designers with multiple levels of adaptive control from architectural to circuit level for power-performance tradeoffs and is well suited for mobile devices operating on limited battery energy.


Synchro-ballistic use of rotating-mirror streak cameras allows for detailed recording of high-speed events of known velocity and direction. After an introduction to the synchro-ballistic technique, this paper details two diverse applications of the technique as applied in the field of high-explosives research. In the first series of experiments detonation-front shape is recorded as the arriving detonation shock wave tilts an obliquely mounted mirror, causing reflected light to be deflected from the imaging lens. These tests were conducted for the purpose of calibrating and confirming the asymptotic detonation shock dynamics (DSD) theory of Bdzil and Stewart. The phase velocities of the events range from ten to thirty millimeters per microsecond. Optical magnification is set for optimal use of the film's spatial dimension and the phase velocity is adjusted to provide synchronization at the camera's maximum writing speed. Initial calibration of the technique is undertaken using a cylindrical HE geometry over a range of charge diameters and of sufficient length-to- diameter ratio to insure a stable detonation wave. The final experiment utilizes an arc-shaped explosive charge, resulting in an asymmetric denotation-front record. The second series of experiments consists of photographing a shaped-charge jet having a velocity range of two to nine millimeters per microsecond. To accommodate the range of velocities it is necessary to fire several tests, each synchronized to a different section of the jet. The experimental apparatus consists of a vacuum chamber to preclude atmospheric ablation of the jet tip with shocked-argon back lighting to produce a shadow-graph image.


We study the novel decays $B^{*}\to B\gamma\gamma $ and $D^{*}\to D\gamma \gamma $ using the framework of the Heavy Meson Chiral Lagrangian (HM$\chi$L) to leading order in chiral perturbation theory. The branching ratios of these decays are expressed in terms of the strong $g_{B^{*}(D^{*})B(D)\pi}$ and the electromagnetic $g_{B^{*}(D^*)B(D)\gamma}$ couplings, thus providing a possible tool for their determination. In the charm case, using the experimentally determined ratios $({D^*}^{0,+}\to D\pi)/({D^*}^{0,+}\to D\gamma),$ we are able to express the branching ratio as a function of the strong coupling only. We thus find $1.6\times 10^{-6} 0.6.$ The expected two-photon differential distributions are presented for both ${B^{*}}^{0} \to B^0 \gamma\gamma$ and ${D^{*}}^{0}\to D^0\gamma\gamma,$ for different values of the couplings involved.


The thesis studies how physical communication factors and cognitive ability of human beings influence each other especially focusing in what roles human genetic needs and brain`s intuition plat in cognitive process. First of all, this thesis reviews the cognitive function, part of brain activities. In this regard, genetic needs related with hypothalamus are categorized. The genetic needs do not work individually but correlate with each other. The needs related with communication are represented with safety needs and benefit needs. The thesis goes further into the influence of each variable factor on these needs. There can be many variables factors comprising communication process but the variable factors capable of influencing the cognitive activities are identified in this thesis. The influences of these variable factors on the cognitive activities of communication participants are also analyzed. The variable factors are divided into six areas: communication purposes and motives, communication participants, communication contents, communication ways, communication situations and linguistic characteristics. How these areas reciprocate with genetic needs, intuition system, emotions, memory and reasoning system are studied in the thesis. In Chapter 4 of this thesis, physical and cognitive models are established based on the above-mentioned relations. The physical model is illustrated in a figure showing the correlation of physically conceivable factors such as motives and purposes, means and ways, preparations and situations of communication while the cognitive model explains the correlation of cognitive activities in the brain. This thesis studies communication factors considering the results of brain research that have been done so far. Changes of brain activities of communication participants need to be measured in real time to prove this thesis but it is not possible to measure this in real time at the moment. However this thesis can be meaningful to become a basis that analysis on communication should not be made only from the perspective of communication contents. Further linguistic studies need to be made to prove how these cognitive activities function in real communication process. In addition to that, it is hoped that biological studies and research be made in order to get concrete proof of the cognitive field.


Nanostructured materials have drawn attentions to the researchers due to the unique physical and chemical properties of nanomaterials, which are different from those of either the bulk materials or single atoms [1]. The reduction of the size of materials causes a deviation of their physical and chemical properties from the bulk and such resultant materials (nanoparticles) are known to possess potential applications and novel properties [2]. Among the different metal oxide films, CdO is an important n-type semiconductor with a cubic structure, which belongs to the II–VI group, with a direct band gap of 2.5 eV and indirect band gap 1.98 eV [3]. Up to now, various methods have been employed to prepare the cadmium oxide nanostructures such as hydrothermal method [4], microwave-assisted combustion method [5], solvothermal method [6], chemical coprecipitation method [7], vapour phase transport [8], thermal evaporation [9], sonochemical method [10] and mechano chemical method [11]. We have used SILAR (successive ionic layer adsorption and reaction) technique for the preparation of thin films which is presently attracting considerable attention, as it does not require sophisticated instrumentation like vacuum system and other expensive equipment. Simple equipment like hot plate with magnetic stirrer is needed for this method [12]. X-Ray Analysis of Cadmium Oxide Nanostructured Films Synthesized with Different Precursor Molarities by Silar Method


The fabrication and construction of five floor framing and subflooring systems was observed and records were kept of the labor times and materials costs of these systems, which were designed for use of 25 132" strip finish flooring. The following conclusions are valid only for systems in which 25/32 11 strip flooring is used as the finish flooring: Framing 1. 2 x 10 joists spaced 24 inches on center were less costly than 2 x 8 joists spaced 16 inches on center . 2. Systems with joists butted over the center girder and tied together with the plywood subfloor were less costly than comparable systems with a lap joint at the center . Subflooring 1. The 1/2'' plywood subfloor resulted in both the lowest material and labor cost for subflooring. The combined material and labor cost was substantially lower than that of any of the other subflooring materials. System 2. The savings (reduced labor and reduced waste) gained by installing 1 x 6 T & G end-matched subflooring did not offset the added cost of this material as compared to 1 x 6 S4S boards. 1. The overall cost of systems employing 1/2 plywood subflooring over conventional joist floor framing was substantially lower than the component system or systems using other subflooring materials. This statement is true without regard to the type of center joint--butted or lapped. 2 . The component system had the highest labor cost and highest total cost although the material cost was somewhat less than the system for which 1 x 6 T & G subflooring was used.


We examine the effect of territorial servitisation on the spatial development of the manufacturing sector in Northeast China. Using data from 34 prefectural cities from 2003 to 2016, we find that t...


In this paper, in order to analyze the grid pattern artifacts, which are caused by using the antiscatter grid in obtaining x-ray projected images, we propose a multiplicative image formation model comparing to the traditional additive model. Through the proposed model, we show that the projected image is a summation of the modulated signals and, instead of using a narrow-bandwidth notch filter, a band-rejection filter should be employed. We also theoretically show the maximal resolution of the recovered images without grid artifacts, and through simulations using real x-ray images, observe the practical meaning of the theoretical analysis.


Context. A number of works have reported that the polarization plane of extragalactic sources as well as the structural axes of radio sources are aligned on the large scale. However, both the claims and their interpretation remain controversial.
Aims. For the first time, we explore the alignment of parsec-scale jets. Additionally, we use archival polarimetric data at different wavelengths in order to compare the relative orientations of the jets and the polarization planes of their emission.
Methods. Using the flux density distribution in very long baseline interferometry radio maps from the Astrogeo database, we determine the parsec-scale jet orientation for the largest sample of active galactic nuclei to date. Employing the method of parallel transport and a sample statistics characterizing the jet orientation dispersion among neighbors, we test whether the identified jets are significantly aligned.
Results. We show that the parsec-scale jets in our sample do not demonstrate any significant global alignments. Moreover, the jet direction is found to be weakly correlated with the direction of the polarization plane at different frequencies.


Air cooling is a method of dissipating heat. It works by expanding the surface area or increasing the flow of air over the object to be cooled, or both. An example of the former is to add cooling fins to the surface of the object, either by making them integral or by attaching them tightly to the object's surface (to ensure efficient heat transfer). In the case of the latter, it is done by using a fan blowing air into or on to object one wants to cool. The addition of fins to a heat sink increases its total surface area, resulting in greater cooling effectiveness. It is observed that the evaporative air cooler takes more floor space also by using wood wool for cooling purpose the consumption of water is more. On the other side, due to continuous running of the cooler, the moisture generates inside the room is more and feels uncomfortable during summer. So to overcome these problems, we are designing the wall mounted air cooler using cellulose pads which will be mounted on the wall with good air ventilation, so the moisture inside the room will be maintained and can use the floor space for other purposes. Also, we can reduce the consumption of water by using the cellulose pads for cooling of water.


Genomic library of soybean cv. Lumut had been constructed in l phage vector. Partial digestion of total DNA by 0.014 units Sau3AI per mg DNA at 37 o C for 30 minutes gave long fragment DNA. Ligation between insert DNA and l vector with molarity ratio of insert DNA to l vector = 2.9 : 1 followed by phage packaging, resulted in the titer of 2.8x10 4 to 3.6x10 5 pfu for 0.5 mg insert plant DNA. Among them, 60 to 91% were recombinants depending on packaging extract protein. By using 1 mg insert plant DNA and packaging extract protein from Stratagene, we obtained 6.6x10 5 pfu recombinant. Since the length of insert DNAs in l recombinant phages were 15 kb in average and the genome size of diploid soybean was 2.23x10 6 kb and 90% of the genom was present in 2 copies, then the genomic library constructed had contained all genome of soybean cv. Lumut.


H. J. Park,1,2 Luke J. Sandilands,1,2 J. S. You,3 Hyo Seok Ji,4 C. H. Sohn,1,2 J. W. Han,5 S. J. Moon,6 K. W. Kim,7 J. H. Shim,4,8 Jun Sung Kim,3 and T. W. Noh1,2,* 1Center for Correlated Electron Systems, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea 2Department of Physics and Astronomy, Seoul National University (SNU), Seoul 151-742, Republic of Korea 3Department of Physics, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea 4Department of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea 5Department of Physics and Photon Science, School of Physics and Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, Republic of Korea 6Department of Physics, Hanyang University, Seoul 133-791, Republic of Korea 7Department of Physics, Chungbuk National University, Cheongju 361-763, Republic of Korea 8Division of Advanced Nuclear Engineering, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea (Received 13 October 2015; revised manuscript received 3 March 2016; published 13 May 2016)


A new approach to constructing a prosodic grammar of Mandarin read speech which describes the mapping from syntactic patterns to prosodic patterns is proposed. It first prepares a large read-speech corpus with syntactic-tree parsing for texts and break-index labeling representing four-layer non-recursive prosodic hierarchical structures for utterances. Then, all realizations of syntactic pattern-break pattern pairs are extracted to learn prosodic grammatical rules. For a syntactic pattern, rules are inferred via calculating the break-type distributions of Pre-B, Post-B, and intra-pattern word junctures from these realizations. In the study, we only investigate the prosodic grammatical rules for four syntactic patterns of determinative-measure (DM) compound, DM+N, DM+DE+N and DM+Modifier+DE+N to verify the feasibility of the proposed approach. With considering the ten syntactic functions of Subject, Object, Topic, Head, Modifier, Attributive, Noun Predicate, Quantitative Complement, and embedded in DE phrase and in Prepositional Phrase, the entropies of pre- and post-boundaries of these four syntactic patterns are reduced significantly. Moreover, detailed rules are inferred via exploring linguistic/semantic interpretations for the occurrence of main prosodic pattern and outliers using the information of phonetic constituents and contexts of syntactic-pattern realizations. Some important factors such as length and semantic relation are found to seriously affect the syntax-prosody mapping.


We read with interest the manuscript by Kovacs et al entitled "Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases" (2). The authors described the clinical and neuropathologic features of three patients with a novel 4-repeat tauopathy characterized by hippocampal spherical inclusions. Previously, Miki and colleagues, also reported another case with similar neuropathologic findings (3). One of the cases reported by Kovacs et al was identified after screening 240 Alzheimer disease (AD) or primary age-related tauopathy (PART) cases, while two of them were identified among 50 patients with subcortical tau pathology consistent with progressive supranuclear palsy (PSP). This prompted us to systematically assess hippocampal sections stained by AT8 immunohistochemistry of 70 PSP and 30 Cortico-Basal Degeneration (CBD) archival cases with the aim to identify potential subjects with hippocampal spherical inclusions. We detected a single case among the PSP group with the same neuropathological features as described by Miki et al and Kovacs et al. The patient was a 69-year-old man who suffered from progressive memory dysfunction, depression, and apathy starting at age of 58. He scored 24/30 at the Mini mental state examination when he was 64. During disease evolution, he developed hallucinations and a rapidly progressive parkinsonism. No further clinical details were available. The clinical diagnosis was dementia with Lewy bodies. The patient died at the age of 69 years after total disease duration of 11 years. There was no family history of neurological disorders or dementia. No mutations in exons 1, 9, 10, 11, 12, and 13 of the MAPT gene were found. Brain was removed after death for diagnostic and research purposes after obtaining written informed consent form the next of kin. Unfixed brain weight was 1115 g. Gross examination revealed mild global brain atrophy accentuated in the hippocampus. The subthalamic nucleus was atrophic and the substantia nigra showed severe pallor. Histological examination confirmed a severe loss of pigmented neurons of the substantia nigra pars compacta, a mild neuronal loss in locus coeruleus and of the external and internal globus pallidus. There was also prominent neuronal loss of the subthalamic nucleus. All these areas were accompanied by astrogliosis and microglial activation. Residual neurons of the brainstem, subthalamic nucleus, and large cholinergic neurons of basal ganglia showed frequent globose tangles. The most striking feature was the severe involvement of the hippocampus. There was a nearly complete loss of pyramidal neurons of the CA4-CA1 sectors and a prominent depletion of granular neurons of the dentate gyrus, consistent with hippocampal sclerosis (Figure 1A,B). Frequent basophilic spherical inclusions of the size of the nucleus reminiscent of Pick bodies were detected in granular neurons of the dentate gyrus and pyramidal neurons of CA1 sector (Figure 1C). Immunohistochemistry showed extensive neuronal and glial ptau pathology. There were frequent tufted astrocytes in all cortical areas, basal ganglia, limbic system, and brainstem nuclei as well as frequent coiled bodies in white matter oligodendrocytes (Figure 1K,L). In addition, a moderate amount of neurofibrillary tangles of the globose type were observed in basal ganglia, subthalamic nucleus, nucleus basalis of Meynert, and brainstem nuclei (Figure 1M). There was also moderate involvement of the pontine nuclei and of the dentate nucleus of the cerebellum, as well as of the spinal cord. The hippocampus showed very frequent spherical inclusions in the dentate gyrus and also in the different sectors of the hippocampus, parahippocampal gyrus, and temporo-occipital cortex together with Neurofibrillary Tangle (NFT) (Figure 1E). Spherical inclusions were also detected in cortical areas and basal ganglia. This pathology was predominantly immunoreactive for 4R tau isoforms and was negative for 3R tau isoforms, except for few NFT in the CA1 sector of the hippocampus (Figure 1F) and an unusual granular cytoplasmic immunoreactivity of some hippocampal neurons (Figure 1F lower right panel). Spherical inclusions were strongly stained by phospho-specific tau antibodies to serine 396, serine 422, threonine 181, and to a lesser extent to serine 262 (all from Calbiochem, La Jolla, CA, USA) (Figure 1G–J). There were only mild B4 amyloid deposits in cortical areas and the limbic system with only few deposits in basal ganglia corresponding to Thal phase 3, and few neuritic plaques (CERAD plaques score A). No a-synuclein or TDP-43 proteins aggregates were detected. These features were consistent with those of PSP with an atypical and severe involvement of the hippocampus, concordant with the observations made by Miki et al and Kovacs and colleagues. Our findings reinforce the notion that this morphological phenotype seems to be different from other established tauopathies. Indeed, our patient presented more prominent supratentorial pathology than in the brainstem in contrast to what is observed in typical PSP (1). The prominent hippocampal involvement is reminiscent of Pick's disease but instead of 3R tau pathology these cases are dominated by 4R tau isoforms. In accordance with the clinical features described by Kovacs, our patient also presented cognitive impairment that could be related to the severe degeneration of hippocampal structures. Cognitive impairment was not reported in the patient described by Miki et al. Our patient also presented psychiatric symptoms, specifically depression and hallucinations. Although no psychiatric symptoms were reported in the patients described by Kovacs, depression was the main symptom in the case reported by Miki and colleagues.


A motor control system in a vehicle having an internal combustion engine with variable capacity, a suction pipe, which is coupled to the internal combustion engine with variable capacity, a controller for controlling the displacement of the internal combustion engine with variable capacity, wherein the controller controls the ignition timing for a wiederzuschaltenden cylinder during the transition from changes shutdown after reconnection.


In this paper, we present an effective implementation of loT(lnternet of Things)which is used for monitoring regular domestic appliances. Our system facilitates energy conservation as well. The proposed system is using the concept of IoT that uses computers or mobile devices to control basic domestic appliances and features automaticallyfrom a large distance. There are five sub-projects namely: automated water tap control system, automated lighting control system, automated door lock system, automated gas detector system and automated temperature control system. The automated water tap control system detects the level of the water and controls the tap accordingly. The automated lighting control system detects the presence of a person in a room and glows the light accordingly. The objective of automated door lock system is to enhance the security of the home. The gas detector system rings an alarm on detecting leakage of any kind of gas. The temperature control system detects the rise in temperature of the room and controls the air conditioner subsequently. The proposed system performs better than all the existing systems in terms of energy efficiency, cost, usability and portability. Our aim is to propose a system which would minimize the wastage of energy as well as human effort starting from our home itself.


How to understand and reason about uncertainty in climate science is a topic that is receiving increasing attention in both the scientific and philosophical literature. This paper provides a perspective on exploring ways to understand, assess, and reason about uncertainty in climate science, including application to the Intergovernmental Panel on Climate Change (IPCC) assessment reports. Uncertainty associated with climate science and the science–policy interface presents unique challenges owing to the complexity of the climate system itself, the potential for adverse socioeconomic impacts of climate change, and the politicization of proposed policies to reduce societal vulnerability to climate change. The challenges to handling uncertainty at the science– policy interface are framed using the "monster" metaphor, whereby attempts to tame the monster are described. An uncertainty lexicon is provided that describes the natures and levels of uncertainty and ways of representing and reasoning about uncertaint...


The development of empirical probabilistic discrete-choice models frequently entails comparing two non-nested models (i.e., models with the property that neither can be obtained as a parametric special case of the other) to determine which is most likely to provide a correct explanation of a particular choice situation. Conventional statistical procedures, such as the likelihood ratio test, do not apply to comparisons of nonnested models. This paper describes three procedures for carrying out such comparisons and explores the ability of each to distinguish between correct and incorrect models. The procedures are: tests against a composite model, the Cox test of separate families of hypotheses, and comparisons based on the likelihood ratio index goodness-of-fit statistic. A modification of the likelihood ratio index is proposed that corrects for the effects of differences in the numbers of estimated parameters in the compared models. The abilities of the various procedures to reject incorrect models and accept correct ones are explored analytically and through numerical experiments. It is shown analytically that, in large samples, the modified likelihood ratio index has greater ability to distinguish between correct and incorrect models than do composite model procedures. The results of the numerical experiments suggest that the modified likelihood ratio index also has greater ability to distinguish between correct and incorrect models than does the Cox test. The numerical results give encouraging indications of the ability of the modified likelihood ratio index to choose the correct model in comparisons of models whose choice probabilities differ by at least 10--15%.


As smallsats become increasingly capable, longer-lived, and have more secondary payload launch opportunities to beyond-GEO destinations, they are expected to play an increasing role in deep space science investigations. This expectation is borne out by several relatively recent NASA Science Mission Directorate solicitations regarding smallsat studies and small innovative missions. With the potential for these smallsats to substantially add to the number of spacecraft operating in deep space, we need to be thinking about ways to support communications with all of them without the huge expense of trying to build a commensurate number of deep space antennas. One approach to this challenge might involve making greater use of beam-sharing techniques that allow all the spacecraft within the beamwidth of a single ground antenna to simultaneously downlink to the antenna. One of these techniques, Opportunistic Multiple Spacecraft Per Antenna (OMSPA), may be particularly suited to smallsats. In the concept for this technique, smallsats within the scheduled ground antenna beam of some other spacecraft, make opportunistic use of that spacecraft's beam by transmitting "open-loop" to a recorder associated with the antenna. These transmissions get captured on the recorder and can be later retrieved, demodulated, and decoded so that the smallsats can recover their data – all without them having to schedule the antenna itself and compete with larger missions for antenna time. Widespread use of such a technique could lead to more efficient use of receiver antenna resources and result in a dramatic increase in downlink throughput. An opportunity to demonstrate the technique occurred in May 2018, when the Mars CubeSat One (MarCO) mission, consisting of two nanospacecraft (MarCO-A & B) launched alongside InSight, a NASA Mars lander mission. To demonstrate the capabilities of OMSPA for this launch window opportunity, X-band downlink telemetry was recorded for all three spacecraft (InSight, MarCO-A, and MarCO-B) at both the Deep Space Network (DSN), using its 34-m antennas, and at Morehead State University (MSU) using its 21-m antenna – with all of the involved antennas pointed at InSight. Open-loop recordings were collected at the DSN using wideband very long baseline science receivers and at MSU using Universal Software Radio Peripheral (USRP) devices operated using GNU Radio. All the recordings were then processed at the Jet Propulsion Laboratory, California Institute of Technology (JPL) using an OMSPA Software Receiver, a signal processing/communications tool used to extract telemetry transfer frames from baseband samples. The results of extracting telemetry data from InSight/MarCO recordings collected by the DSN and at MSU are described in this article. In particular, details pertaining to the processing chain used by the OMSPA Software Receiver to demodulate the DSN and MSU recordings are presented, from carrier/symbol synchronization, to frame alignment using attached sync markers (ASMs), followed by error correction code decoding. Validation results with closed-loop data obtained by the DSN are also presented in order to highlight the viability of OMSPA for future multiple spacecraft demodulation opportunities.


Monthly mean sediment load and runoff changes in the past 40 years are analyzed at Pingshan station,Yichang station,Datong station and Hankou station along the mainstream of the Yangtze River basin and Beipei station in the tributary of the Yangtze River basin,with the help of wavelet transform method.The results indicate that:① the wavelet transform method is the proper method for detecting the influences of water reservoirs on transportation of sediment load and runoff changes.The influences of water reservoirs on sediment load are more serious that those on runoff changes;② Gezhouba dam exerts less influences on runoff changes and sediment load.The down-cut of the riverbed occurrs after the operation of Gezhouba dam,but this influences are not enough to remove the 1-year-period of runoff and sediment load changes;③ The Three Gorges dam exerts increasing influences on sediment load transportation,removing the 1-year-period sediment load of sediment load changes,but shows no influences on runoff changes.The influences of Three Gorges dam on sediment load are adverse to the distance to the Three Gorges dam;④ The influences of water reservoirs on sediment load and runoff changes is related to the size of the river catchment.The sensitivity of influences of water reservoirs on sediment load is less in the larger river catchment.


Is supplied to the two-way front spreading screw 5 of high abrasion resistance which prevents the paving materials fall from the floor with a central passage 30, so as to spread the rotary screw 5 and the car by the front side of the right and left wheels in contact with a spreading . 7 is supplied to rear spreading screw to prevent the paving materials by the usual base plate 32 to which two cars and road wheels in contact with the left and right down, rotary screw 7 by the rear spreading with spreading it to the central and the outer paths. Thus two kinds of paving materials, the brightest band scattered by interaction columns screed 9 simultaneously laid uniformly, as a result, the construction can be inexpensive high durability road.


To improve reality,usability and efficiency of simulation,this paper designs a large-scale,parallel and distributed network simulation system.It can use the actual data from network measurement tools as the base of simulation;partition the network with an optimized goal;by using BGP-like router configuration,it can provide correct and quick remote router simulation;with a script-generator,related simulation scripts can be automated generated.Many security events can be simulated by this system,such as worm diffusions and DDoS attacks,etc.


The Pinus needle powder is processed by the needles of Pinus massoniana and other pine trees,which contains a certain quantity of protein and vitamins,meanwhile rich in carotene.It has been proven that Pinus needle powder is very beneficial to the growth and production of animals and poultry.It can also strengthen disease resistance of the animals and promote the utilization efficiency of the forage.The nutrition value,foraging value of the Pinus needle powder and its application to animal production were reviewed.


The Brief fear of Negative Evaluation Scale (BFNE) has shown good validity and reliability properties in different cultural samples, as well as when it has been translated to other languages (Duke et al., 2006; Gallego, 2010; Gallego et al., 2007; Weeks et al., 2005; Tavoli et al., 2009). Given the relevance of the study of anxiety and social phobia and the need for research tools for Mexican samples, this study presents validity and reliability evidences for a translation to Spanish language of the BFNE (Leary, 1983) in a sample of undergraduate students from Mexico City. Psychometric tests included discrimination analysis for each item, principal component factorial analysis, and confirmatory factor analysis through structural equation modeling. Results show a one factor structure with just eight of the 12 original items. It explains 53.8% of total variance and has good reliability ( α = 0.88). In addition, evidence was found concerning criterion validity for the BFNE: a) It correlates positively with a Trait Anxiety Scale; and b) through an experimental procedure, positive correlations for the BFNE with a State Anxiety Scale and a Self-Presentation Motivation Scale when participants had the expectation of being introduced to another person. The discussion verses in relation to the performance of score reversed items and the theoretical meaning of items and to the observed relationships that support the criterion validity of this translation to Spanish language of the BFNE scale.


tion of duration/progression inherent in the term, as something wrested out of shape: by war and fascism; by the intellectual feud with Sartre and the Communist Left; by the Algerian War of Independence . . . Or as something just begun: the unfinished Premier Homme being, wrote Camus, 'starting for real' (p. 174). Anguish and pessimism thus haunt this biography, but that is the unavoidable result of the biographer's success in setting before the reader the portrait of a writer forced, as he acknowledged in a letter to Jean Grenier in 1959, to become 'resigned to cohabiting with oneself ' (p. 166).


The potential harmful effect of cypermethrin insecticide on soil microbial biomass and its activity was assed from soil collected from an agro ecosystem under controlled laboratory conditions. The insecticide was applied to the soil at field recommended rate (FR) and ten times the field recommended rate (10FR).The incubation study was carried out at 60 % of maximum water holding capacity of the soil sample at 30 0 C for a period of 90 days. Cypermethrin at FR dose resulted in short lived transient toxic effect on soil microbial biomass – C (SMBC), Basal and substrate induced respiration rate (BSR & SIR) and fluorescein diacetate hydrolyzing activity (FDHA). The ecophysiological status of the soil microbial communities as expressed by microbial metabolic quotient (qCO2) and microbial respiration quotient (QR) were also altered for a short period, indicating cypermethrin induced disturbance at FR dose of application. However at 10 FR dose of application the toxic effects were much distinctly observed for a slightly longer period of time. © 2013 Universal Research Publications. All rights reserved


Patients come to the clinic UNS (Universitas Sebelas Maret) Medical Center to get a medical treatment. The clinic provides two health services include dental polyclinics and general polyclinics. Majority of patients do not know exactly how long the process of service from patient registration to getting medicine. Moving queues to each service is an event and people who queue up at each service are state. It is clear that the sum of all possible states is finite. This problem includes a Discrete Event System (DES). One of the uses of petri net is to model a DES. In this research, service flow was built in the clinic using Petri Net and service scheduling was modeled using Max-Plus Algebra. Furthermore, a coverability tree was built to determine the liveness and deadlock of the patient service queue and analyze the petri net flow. The selection of service start time can be chosen randomly to simulate the scheduling and length of service time.


The present invention discloses a terminal and Passive activation WiFi network searching, the method comprising: switching a terminal device configured to detect the received signal, and upon detection of WiFi signals, the switching device is turned on using in the closed state of the WiFi module function performed WiFi Internet search. The method and the terminal of the present invention, by arranging the switching device within the terminal, so that the switching device after receiving the signal WiFi, WiFi module to start looking for the network, to achieve passive activation WiFi network searching mode, and thus can the user need not open at any terminal device WiFi function, a WiFi network can always find the WiFi coverage area of a terminal device while reducing power consumption.


The instrument to be applied in order to raise net circulating capital is stepped coupon bonds, a novel solution non-existent on the Polish market. Restructuring factoring applied sporadically in Poland and Germany is an instrument reducing the demand for the corporate net circulating capital. The article presents the idea of these instruments and the possibility of using them by a company in financial difficulty.


PurposeOnline ride-hailing platforms match drivers with passengers by receiving ride requests from passengers and forwarding them to the nearest driver. In this context, the low acceptance rate of offers by drivers leads to friction in the process of driver and passenger matching. What policies by the platform may increase the acceptance rate and by how much? What factors influence drivers' decisions to accept or reject offers and how much? Are drivers more likely to turn down a ride offer because they know that by rejecting it, they can quickly receive another offer, or do they reject offers due to the availability of outside options? This paper aims to answer such questions using a novel dataset from Tapsi, a ride-hailing platform located in Iran.Design/methodology/approachThe authors specify a structural discrete dynamic programming model to evaluate how drivers decide whether to accept or reject a ride offer. Using this model, the authors quantitatively measure the effect of different policies that increase the acceptance rate. In this model, drivers compare the value of each ride offer with the value of outside options and the value of waiting for better offers before making a decision. The authors use the simulated method of moments (SMM) method to match the dynamic model with the data from Tapsi and estimate the model's parameters.FindingsThe authors find that the low driver acceptance rate is mainly due to the availability of a variety of outside options. Therefore, even hiding information from or imposing fines on drivers who reject ride offers cannot motivate drivers to accept more offers and does not affect drivers' welfare by a large amount. The results show that by hiding the information, the average acceptance rate increases by about 1.81 percentage point; while, it is 4.5 percentage points if there were no outside options. Moreover, results show that the imposition of a 10-min delay penalty increases acceptance rate by only 0.07 percentage points.Originality/valueTo answer the questions of the paper, the authors use a novel and new dataset from a ride-hailing company, Tapsi, located in a Middle East country, Iran and specify a structural discrete dynamic programming model to evaluate how drivers decide whether to accept or reject a ride offer. Using this model, the authors quantitatively measure the effect of different policies that could potentially increase the acceptance rate.


Possible modifications to improve the Clean Air Act of 1977 include: remove all specific emission control directives and replace them with enabling language that gives broader discretionary power to the responsible agencies/ provide for adequate review of EPA's administration of the act by a Presidential advisory board/ establish a clear delineation of federal and state responsibility/ provide for a strong research effort in areas involving acid rain and hazardous pollutants/ provide for increased staffing and advanced training of state and local professional staff/ and provide for the necessary feedback to Congress to insure that the objectives of the act are met in a timely and cost-effective manner. (1 photo)


Among the less frequently encountered, yet widely distributed, items of material culture recovered in the Anasazi Province are tiponi, or Corn Goddess symbols. In the excavation of the Evans Site in the Gallina region of northern New Mexico three tiponi were found. Two, the largest and the smallest, were in the North House; the third was in the South House. All were of sandstone and were simply-fashioned cones, flat on one end and bluntly pointed on the other. Aside from their shape, no distinguishing features were discernible. The largest was 48 cm. in height and 20 cm. in basal diameter; the smallest was 18.4 cm. in height and 15.2 cm. in basal diameter. The tiponi found in the South House was one of a number of miscellaneous stones which had been used as fill in the bottom of the fireplace or had fallen into the pit.


This paper reviews the introduction of factory concepts and practices, based on tools and methods from the evolving field of software engineering, at major software producers, in particular those that explicitly adopted the factory label to describe their software facilities or approach to software development: Hitachi,. We will take over the task and deliver desired results with a guaranteed price and term. Richard Arkwright is the person credited with being the brains behind the growth of factories. After he patented his spinning frame in 1769, he created the first true factory at Cromford, near Derby. This act was to change Great Britain. Before very long, this factory employed over 300 people. Nothing had ever been seen like. Working closely with our clients to deliver bespoke programmes to impact on your business and people producing strong leaders, great organisations, effective strategy and real results. . in a distributed environment. This consultancy in implementing a Software Factory was aimed at validating Procempas current development methodology, implementing the necessary improvements in addition to helping implement the tools that make it possible to manage the development cycle of Procempa applications. Onze diensten zijn: assessment, coaching, loopbaanbegeleiding, talent management. Development Factory is gevestigd in Arnhem. In business, products in digital form turn into merchandise. We can help you in development of manufacturing processes and materials, utilization of additive and digital manufacturing and boosting of the operations of factories and networks. We also accompany new co-creation value networks in manufacturing industry. The Development Factory Sydney. The Development Factory specialises in taking complicated projects that use a variety of different technologies, hardware components and software, to produce innovative, diverse and functional applications. 23 Mar 2010 . With smaller budgets, IT organizations are turning to agile development in the hope of being able to do more with less. We outline seven practices to help CIOs and application developers apply agile and lean practices to support their software factory efforts. 12 Jan 2013 11 min Uploaded by Danielle RThis .is an overview of a project to create a web development team that can deliver quality . Assignment. Develop proposal to establish low cost aircraft final assembly factory in Mexico. Design, layout and commission new facility including recruiting and training workforce and program managing aircraft transfer plan. Business Development Factory. We are a team with more than 20 years experience in sales, management, logistics and human resources. We do things differently, by creating a new space of continuous learning based on practical experience, actions and feelings. When you feel that "good enough is not enough" it means. Existing learning factories are mainly focusing on one subject. Interdisciplinary approaches integrating different points of view are rather rare. This paper introduces a new concept for an interdisciplinary learning factory that includes the areas of product development and production. This new learning factory is focuses on. Development in the learning factory: training human capital. Harry Barton. Cardiff Business School, Cardiff, Wales. Rick Delbridge. Cardiff Business School, Cardiff, Wales. Introduction. It is conventional wisdom that the factories of the future will be sites of continuous improvement, innovation and knowledge creation. The Brick Factory is a team of 20 strategists, designers and developers. Photos Illustrations. BALTAZAR ZARAIK. Developer. GARY ALMES. Director of Web Development. GERRY BLACKWELL. Controller. HANNAH DEL PORTO. Chief Operating Officer. HEYMO VEHSE. Developer. JEI PARK. Senior Designer. Toronto based studio with expertise in custom Shopify App Development and Theme Design. 3 Jul 2017 . Each demand (Service Order) is formalized through a demand management system and developed at the headquarters of the Software Factory. Communication is refined through e-mail, telephone, virtual or face-to-face meetings. From the use of practices in the Projects: development, maintenance and. 1 Jul 2015 . Senior Management. Current Employee Anonymous Employee. Current Employee Anonymous Employee. Recommends. Positive Outlook. I have been working at The Development Factory full-time (More than a year). Pros. Smart people that get things done fast. Cons. Small office space. Growing pains. history of the organization of work: Genesis of the factory system ...guilds declined. Over time the nature of technological change shifted from the introduction of new mechanical contrivances to developments in the application of power (primarily water and wind) to old devices and—even more significantly—to the. UL factory inspections provide customized product inspection support, based on customers' predefined parameters or customer-accepted specifications. These. A specialist BPIF Print Factory Layout Expert will: Conduct a physical survey to determine detailed dimensions of all machinery; Make observations on the current methods of operation; Construct a Work Flow Relationship Diagram; Design alternative layouts for discussion; Create a large-scale drawing showing the ideal. Features. Discusses the impact of concurrent engineering on product development; Provides a better understanding of the tolerances, lead times, coats, and dos and don'ts of design processes; Examines deductive reasoning and systematic approaches involved in troubleshooting and debugging; Explores how to ensure. SWAT Factory is a trusted independent strategic consulting and full project development service team specialized in Digital strategy, Ecommerce and marketing. / Équipe indépendante en accompagnement stratégique et en développement de projets spécialisée en stratégie digitale, Ecommerce et en marketing. The Development Factory, Los Angeles, California. 215 likes · 9 were here. The Development Factory is a proven technology partner to clients in retail,. The physical development of sand play includes large muscle skills as children learn how to dig, pour, sift, and scoop. It also includes eye-hand coordination and small muscle control as they learn how to handle the sand toy accessories. Children's Factory "Kidfetti" is a clean alternative to sand and can be washed as. Learn about the BPDA's development review process, view information about development projects in the BPDA approval pipeline, and learn how you can get involved. 14 Jul 2017 . Going Beyond... "The Disaster Factory" is an essay by Greg Knauss about programmers living in worst case scenarios and why we have responsibility in our jobs and would be happy to be hugged by friends. —Anselm. Una riflessione (attraverso il metodo dei case study) sull'evoluzione dei modelli di leadership e dei principali strumenti di valutazione, sviluppo e valorizzazione delle risorse umane. Un valido supporto per quanti, in contesti di apprendimento sia universitari che professionali, vogliono stimolare il confronto su pratiche HR di. 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