in meal as low as 0.006% to release enough solvent to attain the lower explosive limit in any ordinary confined storage space. This would be due mainly to the "holding power" of the 1% oil content almost certain to be present. The failure to obtain flashes at the lower solvent percentages is probably due in part to absorption of hexane in the oil content of the meal. This method is believed to provide test conditions considerably more severe than those likely to be attained in commercial operations. The apparatus required is simple, and it should be possible to fabricate it in most small machine shops. The method is not elaborate and with careful operation should yield reliable and duplicable results. The preliminary results indicate that it may be sufficiently sensitive. Recommendations It is recommended that this method be tried by other members of the subcommittee and by any others in the industry who are interested. The results obtained should then be subject to rigorous analysis to determine whether the method has sufficient merit to be considered for plant control purposes. A drawing of the concentric ring copper cup tester will be made available on request to those interested in constructing a cup for experimental or control purposes. Summary The hazards of excess residual solvent in solventextracted meals and methods currently used for its measurement are discussed. Preliminary results are reported with a simple copper-cup flash-tester with concentric rings as heating surfaces. Solvent contents as low as 0.03% can be detected. The method is semiquantitative. The method may be useful for plant control purposes. REFERENCES


Fatigue is a feeling of weariness or lack of energy that does not decrease when a person rests. The main reason of occupational accidents caused by humans is stress and fatigue. This study aims to analyze the differences of reaction time and fatigue stage between morning shift workers and night shift workers of coal mining department operators in PT. Kaltim Prima Coal. This research was an analytic observational research with cross sectional approach and purposive sampling technique. Data taken from 30 workers of morning shift and 30 workers of night shift who fulfill the inclusion criteria. The results showed that the average reaction time of morning shift workers was 0.81 seconds and 0.89 seconds for night shift workers. The results of questionnaire showed amount of very tired worker category, tired, and less tired on the morning shift workers for each category were 7, 21, and 2, while the night shift workers for each category were 3, 25, and 2. Results of unpaired t-test for reaction time showed no significant difference (p = 0.2) and the results of the Kolmogorov-Smirnov test for fatigue stage showed no significant difference (p = 0.952) between the morning shift workers and night shift workers of mining coal department operators in PT. Kaltim Prima Coal. Keywords: Reaction time, fatigue stage, shift workers


Seismic monitoring of carbon storage sequestration is a challenging problem involving both fluid-flow physics and wave physics. Additionally, monitoring usually requires the solvers for these physics to be coupled and differentiable to effectively invert for the subsurface properties of interest. To drastically reduce the computational cost, we introduce a learned coupled inversion framework based on the wave modeling operator, rock property conversion and a proxy fluid-flow simulator. We show that we can accurately use a Fourier neural operator as a proxy for the fluid-flow simulator for a fraction of the computational cost. We demonstrate the efficacy of our proposed method by means of a synthetic experiment. Finally, our framework is extended to carbon sequestration forecasting, where we effectively use the surrogate Fourier neural operator to forecast the CO2 plume in the future at near-zero additional cost.


Purpose – The paper aims to develop a theory‐based model of relationship commitment in an online travel domain. The model seeks to explain in detail the antecedents and outcomes of commitment.Design/methodology/approach – An extensive review of relationship marketing and commitment literature helps to develop a model of commitment.Findings – A model is developed based on existing literature. Quality of alternatives, investment size, satisfaction and trust are antecedents of both calculative and affective commitment. Two dimensions of commitment have different impact on word‐of‐mouth communications.Practical implications – Given the intense competition among online travel agents, the proposed model can be used by e‐vendors to develop and maintain long‐term relationships with customers.Originality/value – Commitment has been studied as a unidimensional construct in existing marketing relationship literature. Few research studies relating to this topic have been conducted in online travel context. This paper...


Background: The outbreak of COVID-19 has caused a serious threat to the lives of people all over the world. At present, there is a lack of specific drugs for the treatment of COVID-19, and the development of effective vaccines is also in progress. With the increasing number of patients worldwide, how to choose safe and effective drugs to treat COVID-19 is imminent.

Purpose: To evaluate the safety and effectiveness of hydroxychloroquine, chloroquine, and azithromycin in the treatment of COVID-19.

Methods: We conducted a comprehensive search by combining the MeSH and free words on Pubmed, Embase, Cochrane, Web of Science, medRxiv, and bioRxiv. The type of study is limited to clinical trials and observational studies. We used the Jadad scale and the American Agency for Health Research and Quality tool to evaluate the quality of the literature. A meta-analysis was undertaken using STATA version 15.0.

Results: A total of 14 related articles including 5048 subjects were included in the study, of which 3 articles were randomized controlled studies and 11 articles were observational cohort studies. In terms of drug effectiveness, compared with patients receiving neither drug, there were no significant differences in in-hospital mortality, mechanical ventilation rate, ICU admission rate, and negative conversion rate of SARS-COV-2 for patients receiving hydroxychloroquine or chloroquine. In terms of drug safety, compared with patients receiving neither drug, adverse drug events were no significant differences in patients receiving hydroxychloroquine or chloroquine. In addition, our study also found that compared with hydroxychloroquine or chloroquine treatment alone, combined with azithromycin treatment does not increase the risk of QT interval prolongation and the mortality of hospitalized patients.

Conclusions: Treatment with hydroxychloroquine, chloroquine, or azithromycin, compared with patients receiving neither drug, was not significant differences in drug effectiveness and safety. However, the interpretation of these results may be limited by the small samples and observational studies. So, it is very necessary to conduct more large-scale randomized, double-blind, prospective controlled studies.


Summary To study the aphrodisiac activity of polyherbal formulation, Androcare in different models of experimental animals, mice and rats. The polyherbal formulation, Androcare was gifted from SHRUSHTI, an Herbal Pharma Industry from Bangalore and LD 50 value for the Androcare was conducted as per as OECD guidelines No. 425 upto the dose level of 2000 mg/kg. The aphrodisiac activity was evaluated in various experimental animal models like Effect on fertility in mice, Effect on sperm properties in mice and Sexual behavior on prolonged immobilization stress in rats. The polyherbal formulation, Androcare even upto the dose level of 2000mg/kg. It has not produced any lethal effect. In Effect on fertility model, Androcare only 200 & 400 mg/kg dose treated groups but not 100 mg/kg dose had shown a significant increase in litter size but no effect on M/F ratio. Androcare was tested for its effect on sperm properties with different dose levels and all doses (100,200 & 400 mg/kg) have shown a significant increase in spermatogenic activity with scant intertubular spaces between the tubules. Sexual behavior in prolonged immobilization stress induced model, a significant increase in number of mounts and thrusting and decrease in mounting latency were recorded with Androcare 200 & 400 mg/kg treated doses only but not with 100 mg/kg treated group. The present investigation revealed that the polyherbal formulation, Androcare was found to possess aphrodisiac activity.


ABSTRACT Three-dimensional (3D) porcine nasal mucosal and tracheal mucosal epithelial cell cultures were developed to analyze foot-and-mouth disease virus (FMDV) interactions with mucosal epithelial cells. The cells in these cultures differentiated and polarized until they closely resemble the epithelial layers seen in vivo. FMDV infected these cultures predominantly from the apical side, primarily by binding to integrin αvβ6, in an Arg-Gly-Asp (RGD)-dependent manner. However, FMDV replicated only transiently without any visible cytopathic effect (CPE), and infectious progeny virus could be recovered only from the apical side. The infection induced the production of beta interferon (IFN-β) and the IFN-inducible gene Mx1 mRNA, which coincided with the disappearance of viral RNA and progeny virus. The induction of IFN-β mRNA correlated with the antiviral activity of the supernatants from both the apical and basolateral compartments. IFN-α mRNA was constitutively expressed in nasal mucosal epithelial cells in vitro and in vivo. In addition, FMDV infection induced interleukin 8 (IL-8) protein, granulocyte-macrophage colony-stimulating factor (GM-CSF), and RANTES mRNA in the infected epithelial cells, suggesting that it plays an important role in modulating the immune response.


For multi-user satellite Internet of Things (IoT) systems operating at lower signal-to-noise ratio, spread spectrum techniques are usually used to combat narrowband interference. In addition, the communication performance in the spread spectrum system depends on the anti-jamming ability of the spreading codes (SCs). Therefore, how to design the SCs scheduling strategies under users' requirements and resource constraints has become a crucial problem for satellite IoT systems. In this paper, communication rewards and scheduling delays are introduced as gauges to measure the scheduling performance of the satellite gateway station control center (SGSCC). Specifically, SGSCC must efficiently and effectively allocate limited available SCs over terminal gateways under request at each transmission time slot. The SCs scheduling problem is formulated as a Markov Decision Process (MDP) along with the observed environments composed of resource status and user request status. Then a deep reinforcement learning scheduling algorithm is devised by embedding the idea of Long Short-Term Memory (LSTM) in the standard Double Deep Q-learning (DDQN). Simulation results show that the proposed algorithm can achieve much better performance than traditional algorithms in terms of communication rewards and scheduling delays. Finally, we draw some conclusions.


5 mL-1 SUMMARY Plantations of proteas are new at the department of Cundinamarca, where businesses of production of Leucadendron have been carried out. In these plantations a new disease denominated wilting has been observed. To identify the causal agent of this disease conventional plant pathological tests were conducted to isolate and to verify the pathogenicity of the causal agent under laboratory conditions. Also a molecular characterization was conducted through extraction and amplification of DNA. The DNA amplified fragment was sequenced by BigDye® Terminator v3.1 Cycle Sequencing Kit according to the manufacturer specifications in a sequencer ABI3730XL (Applied Biosystems). Under laboratory conditions the pathogenicity and disease incidence caused by two isolates of fungi obtained were evaluated on the varieties Gold Strike and Petra. The fungi were inoculated both individually and in mixture, using a completely randomized design with a factorial arrangement of 2 x 4. In the inoculations was used a suspension of 10 5 macroconidia mL-1 of water. Also they were evaluated under field conditions at the same concentration and on the same varieties, using a complete block design with factorial arrangement of 2 x 4. The laboratory analysis indicated the presence of two species of Fusarium, which were differentiated through the color of their colonies. According to the molecular analysis, they belong to F. oxysporum (white colony) and Fusarium sp. (red colony). It was confirmed the pathogenicity of both species on the tested varieties.


Tungsten-tellurite glasses with the molar compositions of (60+ x )TeO 2 -(30- x )WO 3 -8BaO-2Na 2 O-0.5Er 2 O 3 ( x =0,5,10,15,20) have been prepared. Effects of WO 3 on optical properties of Er 3+ -doped tungsten-tellurite glasses have been discussed. Along with the WO 3 content increasing, Ω 2 and Ω 6 first increase and then decrease, and the stimulated emission cross-section also behaves in like manner, while Ω 4 changes contrarily. According to the McCumber theory, the maximum peak of σ e is calculate to be 1.00×10 -21 cm 2 at 1.55μm. The maximum FWHM of Er 3+ 4 I 13/2 → 4 I 15/2 emission spectrum is 82nm. In addition, the intensity of upconversion luminescence of the Er 3+ -doped tungsten-tellurite glasses decreases rapidly with the increasing of WO 3 content.


where X ∈ {0, 1}, W ∼ N(0, σ2) and X,W are independent. a) Assume that Pr{X = 0} = Pr{X = 1} = 0.5. Give an expression for the probability of error using the MAP detection rule. You can express your answer in terms of the Q-function, where Q(z) := Pr{Z > z} and Z ∼ N(0, 1). b) If h is doubled and so is σ2, does the probability of error in part (a) changes? How about if h and σ are both doubled? Give an intuitive explanation to your answers. c) Repeat part (a) in the case when Pr{X = 0} = p for general p. d) Suppose Pr{X = 0} = p but the designer of the detector does not know the value of p and uses instead the ML rule. Give an expression for the probability of error as a function of p, h and σ2. e) Suppose h = 1 and σ2 = 1. Plot the two probabilities of error, one under the MAP rule and one under the ML rule, as a function of p ∈ [0, 1]. Compare them and comment.


Abstract: The impact of globalization is experienced most strongly in business and commerce but also increasingly in education. As a result, some scholars have called for a re-envisioning of the role of teachers to model what it means to be a global citizen. In this paper, I acknowledge the need for ESL/EFL teachers to re-examine their identity and roles in light of these global developments. At the same time, I argue that teachers should not lose sight of the importance of honing the craft of teaching English so as to increase their professional capital to mediate the impact of globalization for their students. This article first discusses the changing roles of teachers in a globalized world and highlights the implications for English language teaching and learning.  The ideas are further related to teaching second language oracy (speaking and listening) because of its centrality in developing important 21st Century skills in the globalized world. The article also offers ways in which teacher education that takes cognizance of globalization forces can develop ESL/ EFL teachers' knowledge and beliefs to play their new roles more effectively. Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */
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Lihua You Fuzhou University of International Studies and Trade 350202 female, Han, 1982.12,JianFou Fujian,Lecturer of university, Bachelor's degree ,college English education and teaching Abstract: College English teaching has an important impact on students' future employment, participation in postgraduate entrance exams and other activities, and their ability to use English in the future. Under the current background of quality-oriented education, adopting classroom interactive education mode for college English teaching can effectively activate the classroom atmosphere, help students consolidate English knowledge, promote the development and implementation of English education, and improve the quality of college English teaching.


Disclosed in an embodiment of the present invention are a new security key activation method, access network node, user equipment and UL boosting system when a UMTS and LTE aggregation system is switched to a UMTS single system. The method comprises the following steps: receiving a first downlink key activation time parameter sent by an RNC, and synchronizing the self downlink key activation time with the time represented by the first downlink key activation time parameter according to the first downlink key activation time parameter; activating a new security key according to the first downlink key activation time parameter; and/or obtaining a self second uplink key activation time parameter, and transmitting the second uplink key activation time parameter to the RNC, so as to enable the RNC to synchronize the self uplink key activation time with the time represented by the second uplink key activation time parameter; and activating the new security key according to the second uplink key activation time parameter.


Horn (1972) observed the peculiar absence of the not-all quantifier from the lexicon of all studied languages and suggested that it is so because a lexicalization for it would be redundant, as some has not-all as an implicature. He also argued that even though the redundancy could also be solved by lexicalization of not-all and the absence of some, languages "choose" lexicons with less negations. Katzir and Singh (2013) revisited Horn's puzzle, created a generalization that could capture lower-order and higher-order logical operators more easily and proposed a more explicit system that predicts the absence of the not-all quantifier. Yet, their system lacks some cognitive motivations, and makes some wrong predictions. I suggest a different, frequency-based approach to the puzzle, based on the interaction between usage frequency effects, tendency toward simplicity, and the primitives used for encoding the operators. I propose a computational model that seems cognitively motivated and accounts for the lexicalization pattern observed by Horn.


The relevance of the research is dictated by the introduction of innovations in banking operations. Classical financial and credit institutions are transformed into high-tech platforms that can create new profit algorithms, using artificial intelligence, Big Data technology, and a global information base. The purpose of this study is to analyze the demand for digital services in the banking sector by customers and to propose criteria for determining the degree of digitalization of banks. The statistical method and the method of evaluating the activities of organizations taking into account the fact of digitalization have been used. To obtain objective results, various tools have been used to analyze the information space of the Internet: tools for analyzing search queries "Google Trends" and "Yandex Wordstat" to determine the relevance of providing digital services to customers. The technical part of the study, which is directly related to obtaining information from the Internet using both software tools and "manually", was conducted in the period from 2016 to 2021. The results of the study show the connection between the introduction of innovations and the reform of the financial and banking sector. The data was collected from 150 respondents who are experts in the implementation of digital technologies – artificial intelligence, Big Data, blockchain in the field of financial activity. A confirmatory analysis has been conducted to assess the reliability and validity of the digital technologies used in the financial and banking sector. The study proposes a method for assessing the degree of digitalization of banks: by the level of automation of the main processes; by the number of services provided online; by the speed of operations; by the availability of online services around the clock; by the range of digital technologies used; by the volume of online sales and the volume of transactions conducted using digital technologies.


The issue of assessing the compound socioeconomic and historicocultural values of monuments is addressed. Monuments are part of the historical and cultural heritage of a country, region, or city. They are a potential source of economic development (for example, by means of tourism), but they also have their own indigenous value. A plea is made for planning for preservation of the cultural heritage by emphasizing the intangible attributes of urban monuments. In this context, the notion of option value plays an important role. The actual compound evaluation of cultural monuments, based on both user value and option value, is then undertaken by means of a recently developed multicriteria technique for qualitative assessment, namely the regime method. The method is briefly described and next applied to evaluate the socioeconomic and functional-urban value as well as the historicocultural value of twenty churches in the city of Thessaloniki. The results are presented in visual form by means of bar charts pertaining to three different types of scenarios. These outcomes appear to be reasonably robust across all scenarios. Some remarks are made about the use of such methods in the broader context of monument restoration policy.


THE problem of the country's monetary standard and controversies arising from efforts to deal with it appear persistently and recurrently in American history. From the land-bank episodes of the late seventeenth and early eighteenth centuries to the "tight money" policy of the Federal Reserve System in 1959, the "money problem" has intruded itself vigorously into social and political conflicts, giving American history much of its flavor. The Pine Tree shilling, the Land Bank of 1740, the Continental currency, the provisions of the federal constitution with respect to "bills of credit," Jackson versus the Second United States Bank, greenbacks and greenbackism, "the way to resume is to resume," the "Crime of 1873," "free silver at 16 to 1," the Roosevelt gold program, and the gold-clause cases of 1935-all these certainly enlivened their times. Most of them have been examined intensively and written about extensively, sometimes by historians, sometimes by economists. Frequently, the historians have not been greatly concerned with the basic economic issues. Too often the economists have written history as seen through the glasses of normative monetary theory. The Coinage Legislation of 1834 is a case in point.' In the present note I propose to examine briefly the "Crime of 1873." What was the "Crime of 1873"? Who did what in that year, to whom, and with what venal, corrupt, or fraudulent motives? Briefly, the event was simply the failure of Congress to include in a long, very detailed, and, for the most part, technical revision of the country's laws pertaining to the mints, assay offices, and coinage any provision for the continuing coinage of the standard 412.5-grain silver dollar containing 371.25 grains of fine silver. Answers to the questions about the nature of the "crime" are found largely in the writings of persons, chiefly economists, who deny that there was any crime and then tell us what it was that was done which was not criminal. One of these writers, J. Laurence Laughlin, has told us, in effect, that there was no crime of 1873 but that if there was, it occurred in 1874, not in 1873 !2 Laughlin's point was that real demonetization of the silver dollar resulted not from the coinage legislation of 1873 but from the adoption of section 3568 of the Revised Statutes of the United States (a general revision made in 1874), which said: "The silver coins of the United States shall not be a legal tender at their nominal value for any amount exceeding five dollars in any one payment." Laughlin's comment was: "The Act of 1873 only discontinued its [the silver dollar's] coinage; the provision of the Revised Statutes took away its debt paying power for sums beyond five dollars." This, he argued, was a real blow at the remaining stock of silver dollars, but he insisted that it was an inadvertent blow, a routine and logical consequence of the failure, in 1873, to include the standard silver dollar in the list of coins to be coined at the mints. By absolving those responsible for this 1873 "failure to include" of any sinister purpose, Laughlin, Horace White, A. D. Noyes, Davis R. Dewey, and others have ridiculed and quite successfully discredited the whole notion of a crime. According to them, the "failure to include" represented merely a legal recognition of an economic fact of life-that silver dollars had largely ceased to be coined in the United States following the gold discoveries in California (1848-50) because, under the legal coinage ratio of approximately 16 to 1 adopted in 1834-37, silver had come to be


Chip-based radio frequency identification (RFID) sensor systems have been investigated for structural health monitoring applications. However, the use of chips in sensor tags has drawbacks in terms of cost, durability, and detection capability. In this paper, we propose a reconfigurable RFID-based chipless tag sensor for strain detection, which detects structural strain by observing the offset of the resonant frequency of the antenna and incorporates an encoding unit for tag identification. To realize the reconfigurability of the antenna, a PIN diode is added to control the antenna, and the frequency reconfigurability of the antenna is realized by controlling the turn on/off of the PIN diodes. The Kalman filter algorithm is used to realize the information fusion of multiple sensors to improve the sensor detection accuracy, and the background noise data enhancement is used to expand the original data samples to fuse the information of the three sensors' data, and the relative error after fusion is reduced by about 36% compared with the relative error before fusion compared with separate measurements. The antenna was fabricated by an etching process and measured using vector network analyzer to verify the accuracy of the antenna simulation results.


A product operator description of the nuclei in an ensemble of molecules undergoing intermolecular exchange during the spin-lock period of TOCSY is presented. Experimental measurements of the transfer of magnetization from the CH2 protons in N-acetylglycine to the solvent water protons, via exchange of the NH proton with water protons during the spin-lock period in TOCSY, are shown to be in agreement with theoretical predictions at lower pH values (7.85-9.54) where the rate constants for NH-water exchange are known. Measurements at higher pH (up to 11.03) indicate that the highest rate constant for exchange that can be determined by this technique is τ A 4000 s -1 .


The purpose of this study is to set up a new practicaltechnique to reduce the failure of transpedicular inseration. The narrow portion of the pedicle were marked with stainless wires and guide wires through pedicle to vertebrae were marked with forceps at the entry point. On AP view of X-ray film,the guide wire were divided into intravertebrae and extravertebrae part, the relationship between mark wire circle and middle point of intravertebrae of guide wire indicates the position of guide wire through the pedicle on the cornal plane. If the least distance between this point and the wire was more than 4. 5-mm,the screw will be correctly inserted , while 3mm baseline between this point and the inner cortical wall of pedicle was used in the operation. High accuracy were confirmed both in experiments and operations. An ideal position of the transpedicular screw can be obtained by means of the technique proposed combining the central cannlated screw system.Author's address(Department of Orthopaedic Surgery ,Changzheng Hospital , Shanghai ,200003)


Beginning in 1999, the Canadian Province of Ontario undertook restructuring and tried to implement performance based regulation for local electricity distribution utilities. Regulatory parameters were based on productivity research covering 1988-1997 that found little productivity difference by size, but wide variations in costs, factor mix, financing, and returns to capital among utilities. While some utilities questioned their ability to improve efficiency, other observers maintained many utilities were over-capitalized, especially from third-party financing paid by customers for connectionsdevelopment charges; these observers noted that rates, profits, and valuations would be inflated. Despite its pervasive use, we can find no literature dealing with the implications of third-party funding. We assess the effects and adjustment dynamics of regulatory and financing changes on costs, factor mix, and performance. Copyright 2007 The Authors Journal compilation © CIRIEC 2007.


Artificial neural network (ANN) is complicated computational systems mainly act based on biological neural system. The viewpoint of restriction in solving physical models in phenomenon of food stuffs is the majority of ANN application in modeling of physical reaction of foodstuffs, additionally ANN demands as an advanced data treatment approach not only in modeling but also in inspection stages of food processing and final products. Ever since meat and meat products undergo chemical reactions to become spoiled, ANN may consider as a new method in such a way of inspecting and forecasting quality of food materials.


Composition for inhibiting the galvanic corrosion of the printed circuit board. By applying a corrosion resistant coating composition to a printed circuit board, to prevent chemical mechanisms leading to galvanic corrosion, to prevent corrosion, it is possible to protect the product from corrosion. Corrosion resistant coating composition, a) mercaptan, b) ethoxylated alcohols, and c) a molybdate, tungstate, at least one metal vanadate is selected zirconium, and from the group consisting of cobalt containing ionic species. .BACKGROUND


This article investigates the determinants of women ' s additional unpaid work during the specific circumstances of the COVID-19 pandemic lockdown. Apart from the influential factors usually investigated in the standard model of unpaid work, we contribute to recent research by including variables such as financial literacy and family financial fragility. Pandemic lockdown altered the normal functioning of families and created financial uncertainty. Thus, we hypothesised that women ' s financial literacy and family financial fragility influenced women ' s decision to take on less or more unpaid work and could alter the division of unpaid work between women and other family members. We employed real-time individual-level data from the survey that we conducted during the second lockdown restrictions in January and February 2021. Croatia is an interesting case to investigate unpaid work determinants because although it has joined the E.U. and accepted positive legal aspects of gender equality, conservative gender norms still dominate there. The results revealed that women ' s financial literacy negatively affects women ' s willingness to take on more unpaid work while the deteriorating family financial situation in the pandemic has a positive effect.


The feature points of the moving target in the video can be tracked through optical flow algorithm. When the target exists a movement with a relatively large scale,it is difficult to meet the image consistency hypothesis of optical flow,which results in the loss of tracked feature points. Concerning this problem,a method of moving human feature points tracking based on Lucas-Kanade pyramidal optical flow algorithm was proposed. First,the moving region of the human was obtained by the difference between the consecutive frames. Then,some feature points of the start frame were detected with the SIFT algorithm. Finally,the feature points were tracked in the subsequent frames through the image pyramidal optical flow.The experimental results suggest that the algorithm performs well on the feature points tracking of large scale movement and the tracking accuracy is improved.


Background: Sickle cell disease (SCD) is one of the most common single gene disorders worldwide and is characterised by significant morbidity and early mortality.[1] Pregnancy in SCD is associated with an increased risk of maternal and foetal complications.[2,3] The 2011 RCOG and the 2021 BSH guidelines[5,6] on the management of pregnancy in SCD have provided the basis for best practice care in the UK over the past decade and is the guidance which we follow in Ireland. To date, there is no published data on outcomes for pregnant women with SCD in Ireland. The number of Irish patients with SCD has risen over the past 20 years. Without a national database, the exact prevalence is not known but currently there are at least 600 adults and children with SCD in Ireland, whose population is just over 5 million.[4] Aims: Our study assesses outcomes of pregnant patients with SCD from 2015 to 2022. Our aims were to: * Assess adherence to current guidelines * Assess pregnancy outcomes and maternal complications * Assess transfusion rates amongst our patient cohort. Method(s): This is a retrospective cohort study. We do not have a directly matched cohort, but have compared our findings to published data on Irish pregnancy outcomes from the Irish Maternity Indicator System National Report and have correlated our findings with studies of women with SCD who were managed in UK centres.[8,9,10] Results: We reviewed outcomes of 29 pregnancies in 19 women over a 7-year period. The median age was 29 (range 20-41) and the predominant maternal sickle genotype was HbSS (65.5%). Before conception, 55.2% of cases had pre-existing complications of SCD, including acute chest syndrome (ACS), pulmonary hypertension (PHTN) and prior stroke. In accordance with current guidelines, 100% of women (n=29) were prescribed folic acid, penicillin, and aspirin prophylaxis. 51.7% (n=15) of women had documented maternal complications during pregnancy, including ACS (34%), vaso-occlusive crisis (34%), gestational diabetes (10%), VTE (3%) and UTI (3%). Two women (7%) developed Covid-19 pneumonitis despite vaccination. There was one case of maternal bacteraemia (3%). 65.5% of cases (n=19) required blood transfusion during pregnancy. One woman was already on a blood transfusion programme for disease modification prior to pregnancy. In 6 cases (20.6%), a transfusion programme was commenced during pregnancy due to prior pregnancy complications or intrauterine growth restriction. During pregnancy, 27.6% (n=8) of women required emergency red cell exchange for ACS. Prior studies have suggested that between 30% and 70% of pregnant women with SCD require at least one blood transfusion during pregnancy.[8,9,10] By comparison, only 2.6% of the Irish general obstetric population required transfusion during pregnancy.[7] 20.6% (n=6) of births were preterm at <37 weeks' gestation. There was one live preterm birth (3%) at <34 weeks and one intrauterine death (3%) at 23 weeks' gestation. Similar to UK data[9], 31% of women required critical care stay (n=9) during pregnancy, in comparison with 1.44% nationwide in 2020.[7] Conclusion(s): It is well established that pregnancy in SCD is high risk, and despite adherence to current guidelines, we have shown very high rates of critical care admission, significant transfusion requirement and hospital admissions. Our findings are comparable to published UK outcomes and they further support the need for a comprehensive specialist care setting for this patient cohort.


To enhance oral bioavailability and decrease the dosing frequency of 5-Fluorouracil

Cancer is one of the most dreadful diseases for which complete cures are not possible, but
colorectal cancer is completely curable if diagnosed at an early stage. If diagnosed in late-stage, 5-Fluorouracil (5-FU) is mostly recommended for its effective treatment, but the challenges associated with this
drug are short elimination half-life, severe side effects, as well as non-specificity. The challenges can be
better addressed by fabricating microbeads using the QbD approach. To enhance the oral bioavailability
of 5-FU and to target the colon for the effective treatment of colorectal cancer, the microbeads were
fabricated by emulsification crosslinking method using Box-Behnken design.

To target the colon for effective treatment of colorectal cancer with enhanced oral bioavailability.

The microparticulate drug delivery system was fabricated by using the emulsification crosslinking method by implementing a quality design approach with risk assessment followed by characterization such as FTIR, DSC, TGA, XRD, in vitro drug release, in vitro cytotoxicity study and in vivo
pharmacokinetic studies.

The patient-centric quality target product profile (QTPP) was set. QTPP inspired critical quality
attributes (CQAs) were searched out. The critical material attributes (CMAs) and critical process parameters (CPPs) influencing CQAs were distinguished. The seventeen formulations were fabricated employing Box Behnken Design, followed by optimization using numerical and graphical optimization techniques and the optimized microbeads were subjected to in vivo pharmacokinetic and in vitro cytotoxicity
studies using HT 29 cell lines. The results revealed that 5-FU-loaded microbeads exhibited significantly
more cytotoxic, and bioavailability was found to be nearly doubled as compared to pure drugs.

5-FU-loaded microbeads can be developed and optimized successfully by using quality by
design approach and coating with eudragit S100, which can be targeted to the colon for the effective
treatment of colorectal cancer.


ISSN-2277-1956 /V1N2-459-467 Improving communication efficiency with adaptable transmissions for Uncoordinated WLANs A.Nithya , M. Jothimani 2 II Communication Systems, K. S. R. College Of Engineering, Tiruchengode, Namakkal Dt Tamil Nadu, India Assitant Professor, K. S. R. College Of Engineering, Tiruchengode, Namakkal Dt Tamil Nadu, India Email: 1 email@example.com, 2 email@example.com AbstractCampus and enterprise wireless networks a re increasingly characterized by ubiquitous coverag e and rising traffic demands. Efficiently assigning channels to access points (APs) in these networks ca n significantly affect the performance and capacity o f the WLANs. In this paper we show that communicati on efficiency can be improved significantly with adapt able transmission through multihop routing. First, we fix the data rate to some constant value i.e. 20 packet s/sec then we vary the data rate according to the p resent network condition. By using Admission control conce pt we adapt the data rate of the network's data flows. If there is no packet loss or there network is under n ormal condition we increase the data rate to higher value i.e. sending more packets than 20pak/sec otherwise we reduce the data rate to normal value. The Advant ages are 1. The throughput is increased in the network 2 . We avoid congestion in the network. In this paper we consider four parameters (Throughput, packet drop, packet delivery ratio, energy) with the existing me thod (CACAO). We conduct extensive simulation study and comparisons using network simulator 2(NS2).


Thomas Buergenthal, himself a victim of serious human rights abuses as a child, has over the years established himself as a world leader in promoting international human rights law. One of the youngest survivors of Auschwitz and Sachsenhausen, Buergenthal spent four of the first ten years of his life in Nazi concentration camps. The horrors he experienced in his youth have no doubt had much to do with his professional activities, which have propelled him into becoming an internationally acclaimed human rights advocate. After the war, Buergenthal immigrated to the United States, where he went to college and law school, earning, among other degrees, a doctorate in international legal studies from the Harvard Law School. He became a law professor, specializing in international law and international human rights. Without ever giving up a full-time academic career, Buergenthal has at different times during the past three decades served as judge and as President of the Inter-American Court of Human Rights, as one of three Commissioners on the UN Truth Commission for El Salvador, and as the first US citizen to be elected to the UN Human Rights Committee. He has represented the United States at various diplomatic conferences within the framework of UNESCO and the Organization of Security and Cooperation in Europe, and was the founder and first President of the Inter-American Institute of Human Rights in Costa Rica. Through his scholarship, judicial and diplomatic activities as well as the force of his personality and commitment, he has made lasting contributions to the cause of human


.............................................................................................. ii CHAPTER ONE: THE PROBLEM................................................................1 Background of the Problem....................................................................1 Purpose of the Project..........................................................................2 Importance of the Project.....................................................................3 CHAPTER TWO: REVIEW OF THE LITERATURE...........................................5 Defining Project-Based Learning............................................................5 Benefits Associated with PBL...............................................................10 Benefits of PBL in Mathematics...........................................................14 Effective Implementation of PBL in Mathematics........................................16 Conclusion ...............................................................................................................24 CHAPTER THREE: METHODOLOGY...................................................................25 The Process of Unit Development..........................................................25 Project-Based Learning Considerations...................................................26 CHAPTER FOUR: THE UNIT...................................................................28 Cover Page....................................................................................29 Unit Overview................................................................................30 Lessons and Assessment Overview........................................................34 Lesson 1.......................................................................................45 Lesson 2.......................................................................................49 Lesson 3.......................................................................................52 Lesson 4.......................................................................................55 Lesson 5.......................................................................................58 Lesson 6.......................................................................................61 Lesson 7.......................................................................................64 Lesson 8.......................................................................................67 Lesson 9.......................................................................................71 Lesson 10......................................................................................75 Lesson 11......................................................................................80 Lesson 12......................................................................................83 Lesson 13......................................................................................85 Lesson 14......................................................................................88 Lesson 15......................................................................................91 Lesson 16......................................................................................93 Lesson 17......................................................................................96


This paper aims to characterize Hom-Leibniz superalgebras and HomLeibniz Poisson superalgebras, presents the methods to construct these superalgebras. Moreover, derivations and representations of HomLeibniz Poisson superalgebras are also investigated.


ABSTRACT Employing data on National Football League (NFL) quarterbacks drafted between 2002 and 2012, the authors consider whether factors correlated with a quarterback being more productive in the NFL are the same factors that correlate with an improved draft position. In particular, the authors consider the relevance of scores on the Wonderlic test. Contrary to all prior literature on the subject, the authors find that performance on the Wonderlic test is positively correlated with NFL performance. However, the authors find no clear evidence that Wonderlic scores are correlated with draft position. Beyond this primary finding, the authors reveal many other interesting results that should help researchers better understand a quarterback's progression from college to the NFL.


A good financial report produced by the company is a reflection of the actual condition of the company and there are no errors. However, management performance is sometimes not as good as expected, so that financial statement fraud can occur for the sake of a good company image. This study is a quantitative study that aims to examine the effect of the pentagon fraud as proxied by eight consisting of three variables from the pressure element (financial target, financial stability, external pressure), two variables from the opportunity element (ineffective monitoring, external auditor quality), one the variable from the element of rationalization (change in auditor), one variable from the element of competence (change in director) and one variable from the element of arrogance (frequent number of CEO's picture) on the existence of fraudulent acts of financial statements. This study uses secondary data with purposive sampling, there are 16 consumer goods industrial sector companies listed on the Indonesia Stock Exchange in 2017-2020. The results of this study prove that the variables of pressure and arrogance have a positive influence on the existence of fraudulent acts of financial statementsl


This paper reports the successful fabrication and testing of all-diamond micro-electrode-arrays (MEAs) for use in neural recording and chemical detection applications using standard electrochemical methods. The MEAs have been tested through in vivo neural recordings. Also, electrochemical probes are reported using diamond as working and reference electrodes, achieving a potential window of about 4 V.


Three main features of the soil massif are taken into account during the evaluation of the safety of deep well drilling at the Caspian shelf – weak soils, shallow gas accumulation and the presence of tectonic faults. The identification of sites hazardous for the rig installation is carried out by using dual-frequency continuous sub-bottom profiling and high-resolution seismic. In some cases, the limited volume of high-resolution seismic data is insufficient for the evaluation of drilling safety at the designated rig locations. The use of 3D seismic data is considered for the evaluation of the safety of the drilling of deep exploration wells in the depth interval between 150 m and 800 m.


A 19-year-old woman presented with a 2-month history of low back pain, night sweats, and weight loss. Examination revealed localized tenderness over the proximal lumbar spine. Her chest was clear and she had no lymphadenopathy. Spinal radiographs were normal and computed tomography (CT) demonstrated a lytic lesion in the spinous process of the L2 vertebra. CT-guided aspiration cytology yielded acid-fast bacilli, and a diagnosis of tuberculous (TB) spondylodiscitis was made. Subsequent investigations showed a raised erythrocyte sedimentation rate, but sputum tests for AFBs were negative and she was human immunodeficiency virus (HIV)-negative. She was treated with antituberculous drugs, including isoniazid (INH), rifampicin, pyrazinamide, and ethambutol for 3 months, and INH and rifampicin for another 9 months, and was then discharged symptom-free. Three years later, she was investigated for infertility. The laparoscopy examination revealed bilateral tubal occlusion presumed to be tuberculous. Her ovaries were normal. She was put on a further course of anti-TB treatment for the next year. She presented on a third occasion 3 months later with a second episode of back pain. A bone scan was done that demonstrated abnormal uptake in the thoracic spine, skull, pelvis, and long bones.


This paper investigates the influence of audit committee (AC) and internal audit (IA) on fair value hierarchy (FVH) in financial instruments disclosure under the amendments made in March 2009 to IFRS 7 in Mauritius. Specific data on FVH was collected from the annual reports of the top 30 listed companies for the period 2010-2013. A disclosure index was then constructed, and the impact of AC and IA is investigated. Banks and insurance companies still need to improve the disclosure of FVH (particularly level 3 hierarchies) by 20%-25%. The existence of AC and the competence of its member(s) are statistically significant whereas its independence is moderately significant. The presence of IA function is positive but moderately significant whereas independence and competence are positively related but insignificant. This paper informs regulator(s), practicing accountants/auditors and professional associations on the effective influence of AC and IA on disclosure practices of FVH in financial instruments.


Barry J. Shelp, Craig S. Walton, Wayne A. Snedden, Lucie G. Tuin, Ivan J. Oresnik and David B. LayzellShelp, BJ., Walton.C.S..Snedden,W.A..Tuin.L.G.,Oresnik,I.J.andLayzell.D.B.1995. Gaba shunt in developing soybean seeds is associated with hypoxia. - Physiol.Plant. 94: 219-228.In the present study we investigated the proposal that Ihe )'-aminobutyrate (Gaba)shunt in developing soybean (Glycine max [L.] Merr.) seeds is associated with hypoxia.The ontogeny and pH profile of enzymes associated with glutamate metabolism(glutamate decarboxylase [EC 184.108.40.206]. Gaba transaminase [EC 220.127.116.11], succinicsemialdehyde dehydrogenase [EC 22.214.171.124], glutamate dehydrogenase {EC 1.4.U],glutamate:oxaloacetate transaminase [EC 18.104.22.168], glutamate:pyruvate transaminase[EC 18.104.22.168] and 2-cxoglutarate dehydrogenase complex [EC 188.8.131.52]) and hypoxia(aicohol dehydrogenase [ADH, EC 184.108.40.206] and pyruvate decarboxylase [PDC, EC18.104.22.168]) were determined in cotyledons, nucellus and seed-coat tissues. Gaba-shuntenzymes were ubiquitous in the developing seed. Activities of enzymes catalyzingglutamate-C entry into the Krebs cycle via 2-oxoglutarate were generally greater thanthose of Gaba-shunt enzymes. In cotyledons, the activity of ADH increased throughoutseed development (up to 72 days after anthesis [DAA]), whereas PDC was static duringearly development, then increased. In contrast, the activities of ADH and PDC inmaternal tissues (nucellus and seed coat) were initially high, then declined dramaticallyafter .37 DAA. The adenylate energy charge (AEC) = ([ATP] + 0.5 [ADP])/([ATP] + ]ADP] + [AMP]) of soybean seeds from fruits (37 DAA) frozen in situ waslow (0.67±0.01) compared to the AEC of adjacent pod tissue (0.82±0.04) andcotyledons exposed to air (0.84±0.01). A 60-min time-course study showed that therate of ]U-'^C]-glutamate catabolism by an intact excised cotyledon at 37 DAA wasmarkedly lower at 8 and 0% O: than at 21%; the pool size of ['•'C]-Gaba wasunaffected. The data indicated that: (i) Gaba-shunt activity is not a response to limitedglutamate deamination/transamination: (2) the soybean seed is hypoxic; and (3) therelative partitioning of glutamate-C through glutamate decarboxylase is increased byhypoxia.Key words - Adenylate energy charge, Gaba shunt, glutamate decarboxylase, Glycinemax. hypoxia. Krebs cycle, stress.B.J. Shelp icorresponding author). C.S. Walton, W.A. Snedden andL. G. Tuin. Dept ofHorticultural Science and Interdepartmental Plant Physiology Program. Univ. ofGiielph. Guelph, ON. Canada N1G2W1; I.J. Oresnik and D.B. Layzell. Dept ofBiology. Queen's Univ., Kingston. ON. Canada K7L3N6.nucellus, which separates the seed coat from the embryo,Introanction Balance sheets for the utilization of amino compounds inDeveloping seeds must receive their nutrients for growth maturing fruits of cowpea (Peoples et al. 1985) and inand development from the mother plant (Pate 1984, developing seeds of soybean (Micallef and Shelp 1989a)Thome 1985), The major form of N delivered to a soy- indicate that many other amino acids present in seedbean embryo is generally helieved to he glutamine (Rain- protein are synthesized in situ. Thus, glutamate and/orbird et al, 1984), hut Hsu et al, (1984) suggested that glutamine are probably involved in a number of bio-glutamine is quantitatively converted to glutamate in the synthetic reactions leading to the synthesis of aminoReceived 7 September, 1994; revised 17 February, 1995


The invention relates to a device (10) for successively emptying filled with rod-shaped products containers (14) into a discharge hopper (18) or the like, comprising a feed device (11) for feeding filled with products container (14), a transfer device (13 ), by means of which the containers filled with products (14) (of a pick-up position 17) arranged in the area of the discharge hopper (18) and back into a delivery position (19) can be transported, as well as below the feed means (11) transporting means (12) for transporting away the emptied container (16), which is characterized in that the transfer device (13) comprises a cassette (21) which is vertically movable up and down and pivotable as well as for holding a container (14, 16) during the entire emptying formed and arranged. The invention further relates to a corresponding method.


Elizabeth Barry is a white mother of three who went through a divorce five years ago. Since the divorce, Elizabeth has remained economically secure as a result of a rich array of resources at the personal, institutional, and neighborhood levels. Her personal network is particularly strong, as her parents have provided regular and generous financial assistance, including clothing, camps, and substantial college savings accounts for her children. This support has freed up money for Elizabeth to invest in her business. The business has thrived under her care, providing regular income and allowing her to save for retirement. Elizabeth's children attend the high-quality public schools in their middle class, majority-white Midwestern suburb. This is particularly valuable for her youngest son, who has autism and receives special services from the school. Due to the recent downturn in the economy, Elizabeth's home lost about 25% of its value, but she has been able to weather this loss of home equity, as well as unexpected medical expenses and tax bills, largely due to her parents' support. Elizabeth also expects to receive about a quarter of a million dollars in inheritance eventually, which she plans to use for her retirement and to support her autistic son. Danielle Meehan is an African American mother of two. Like Elizabeth Barry, Danielle's family stepped in to lend support when she got divorced. Her grandfather helped cover some immediate bills and gave Danielle a few hundred dollars to help her get by. Going back to school earn her MBA while working full time, Danielle has amassed more than $70,000 in student loan debt. In addition to this education debt, the home Danielle purchased in 2003 has dropped in value by nearly $20,000. Following the divorce she bought a home in the best area she could afford. Yet, concerned with the safety and quality of the local public schools, she sent her daughter outside the district, first to a private and then to a charter school. With no home equity, the little savings Danielle has built go directly towards supporting her children and extended family. In fact, instead of receiving financial assistance from her family in recent years, Danielle says, " I am the family assistance. " She has taken a loan against her 401(k) to pay for her daughter's college, helps financially support her cousin, and pays for her mother's nursing home costs.


Edge storage stores the data directly at the data collection point, and does not need to transmit the collected data to the storage central server through the network. It is a critical technology that supports applications such as edge computing and 5G network applications, with lower network communication overhead, lower interaction delay and lower bandwidth cost. However, with the explosion of data and higher real-time requirements, the traditional Internet of Things (IoT) storage architecture cannot meet the requirements of low latency and large capacity. Non-volatile memory (NVM) presents new possibilities regarding this aspect. This paper classifies the different storage architectures based on NVM and compares the system goals, architectures, features, and limitations to explore new research opportunities. Moreover, the existing solutions to reduce the write latency and energy consumption and increase the lifetime of NVM IoT storage devices are analyzed. Furthermore, we discuss the security and privacy issues of IoT devices and compare the mainstream solutions. Finally, we present the opportunities and challenges of building IoT storage systems based on NVM.


The present invention, vitamin E, vitamin C, and including carotenoids, compositions for preventing or treating kidney disease, and the administration of such compositions to animals susceptible or suffering from kidney disease It encompasses a method for preventing and treating kidney disease. In a preferred embodiment, the composition is mixed with one or more food ingredients, to produce useful food composition for preventing or treating kidney disease.


Abstract: Therapeutic approaches for non‐Hodgkin's lymphoma (NHL) are currently based on the International Prognostic Index (IPI). Research on biological prognostic factors has been actively pursued in recent years, with serum vascular endothelial growth factor (VEGF) and interleukin‐6 (IL‐6) being identified as prognostic factors for NHL. Here, we determined that serum VEGF and IL‐6 levels are independent prognostic factors for aggressive lymphoma. Compared with normal controls, serum VEGF and IL‐6 levels were significantly higher in patients with aggressive lymphoma or adult T‐cell leukemia/lymphoma. Furthermore, overall and disease‐free survival rates for patients with high levels of VEGF or IL‐6 were significantly poorer than for patients with low levels. In addition, the prognosis for patients with high levels of both serum VEGF and IL‐6 was significantly poorer than that for patients with high levels of either VEGF or IL‐6 or with low levels of both VEGF and IL‐6. Multivariate analyses of a variety of prognostic factors, including the five IPI factors, revealed that serum VEGF and IL‐6 were both independent prognostic factors for overall survival of aggressive lymphoma. Therefore, a combination of VEGF and IL‐6 represents a useful prognostic factor for aggressive lymphoma.


This study aims to determine the role of government and society in zakat in East Java. This is assessed using the macro dimensions of the national zakat index. This study uses a quantitative descriptive research method with the National Zakat Index analysis tool. The research was conducted by giving a questionnaire to BAZNAS regarding the required data. The results obtained by BAZNAS of East Java Province on the macro dimension is 0.31 which indicates a poor value. This was caused by several factors, including the low budget support for BAZNAS operational costs and the very low value of the muzakki ratio for both individuals and business entities.


In-situ seismic attenuation was measured through the upper basalt series using vertical seismic profile (VSP) data collected on ODP Leg 104 at the Vdring Plateau, located along the Norwegian continental margin. Assuming a constant Q model, measurements were made using the spectral ratio method over the bandwidth 7.8 to 62.5 Hz. An effective at tenuation of 2.7 x 10 _4dB-s/m ± 0.6 x 10~ 4 (Q-effective = 25) was measured over a 525-m interval. Apparent at tenuation due to intrabed multiple reflections was computed using synthetic VSP data generated from a well log-derived impedance model. The contribution of apparent attenuation can account for all of the observed attenuation in the up per basalt series. Further, the computed apparent attenuation was found to vary with frequency /as/ 09 over the band width 7.8 to 62.5 Hz, indicating that the initial assumption of constant Q was not valid. Q-apparent was computed at two frequencies: at 30 Hz Q-apparent = 55, and at 60 Hz Q-apparent = 29. Within our range of error, intrinsic attenu ation in the upper basalt series is less than 0.6 x 10 ~4 dB-s/m (Q-intrinsic > 115).


As lasers, photosensors, and computational imaging techniques improve, holography becomes an increasingly attractive approach for imaging applications largely reserved for photography. For the same illumination energy, we show that holography and photography have nearly identical noise performance. Because the coherent field is two dimensional outside of a source, there is ambiguity in inferring the three-dimensional structure of a source from the coherent field. Compressive holography overcomes this limitation by imposing sparsity constraints on the three-dimensional scatterer, which greatly reduces the number of possibilities allowing reliable inference of structure. We demonstrate the use of compressive holography to infer the three-dimensional structure of a scene comprising two toys.


Permittivity versus temperature characteristics and Curie–Weiss exponent (CWE) γ in the universal Curie–Weiss law [e−1=em−1[1+(T−Tc)γ∕(2δ2)](1⩽γ⩽2)] as a function of dc bias field were obtained for ⟨001⟩, ⟨011⟩, and ⟨111⟩ oriented 0.76Pb(Mg1∕3Nb2∕3)O3–0.24PbTiO3 single crystals. Results indicated that γ is a function of dc bias field and three different oriented crystals show slight different γ values but the similar dc field dependence.


Abstract In a recent paper of the authors the homogeneity properties of the kinetic energy functional have been studied prompted by the work of Parr and Liu. This then motivates a similar study of the Pauli energy. A new expression for the electron density is derived.


Guided by the theoretical and methodological concepts about some questions concerning cultural identity, the present study analyzes the contribution of the contents spread by the string literature in the process of building and maintenance of the cultural identity. Developed from a qualitative-descriptive approach, the research is carried out in two phases: bibliographical and exploratory. It presents analysis of three stories that show the relation between cultural identity and contents in the string literature. The results reveal a strong presence of elements and/or cultural manifestations in the contents spread in the string literature.


Extracellular matrix (ECM) degrading enzymes, including matrix metalloproteinases (MMPs), are critical for cartilage destruction in the progression of osteoarthritis (OA). Thus, identifying novel drugs, which suppress the synthesis of MMPs may facilitate the treatment of OA. The cytotoxicity of lycorine was determined using a CCK8 assay. The effects of lycorine on IL‑1β‑induced upregulation of MMPs and activation of mitogen‑activated protein kinase pathways were detected by western blot analysis and reverse transcription‑quantitative polymerase chain reaction. Hematoxylin and eosin staining and Safranin O staining were used to evaluate the effect of lycorine in a mouse anterior cruciate ligament transection model. In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin‑1β (IL‑1β)‑induced synthesis of MMP‑3 and MMP‑13 in vitro. Molecular analysis revealed that LY abrogated the phosphorylation of c‑Jun N‑terminal kinase (JNK) and the activation of the nuclear factor (NF)‑κB signaling pathway caused by IL‑1β stimulation. In addition, in vivo experiments in a mouse anterior cruciate ligament transection model confirmed the protective role of LY on cartilage. Taken together, the data obtained in the present study demonstrated that LY suppressed the IL‑1β‑induced expression of MMP‑3 and MMP‑13 through inhibition of the JNK and NF‑κB pathways, suggesting that LY may be used as a potential drug for the treatment of OA.


IEEE 802.11(Wi-Fi family of standards) have been widely adapted for internet access due to the ease of deployment, freedom of configuration and interoperability of the devices. However, in dense deployments of such Wireless Local Area Networks (WLANs) as in overlapped Basic Service Sets (OBSSs) and with the options to enhance the channel bandwidths to 80/160 MHz (for IEEE 802.11ac/ax), due to increased contention the performance suffers. This is manifested as reduction in the overall throughput much lower than that can be ideally achieved by the network. Thus, if the throughput of a network prior to the deployment is roughly known, the real-life deployment could be optimally chosen by reworking the deployment parameters. Machine Learning (ML) is a promising approach to capture the complex interactions among the AP/STA entities, learn the complex inter-relationships and be able to predict the performance parameter i.e. throughput of a given deployment with minimal or partial inputs. To do so, a large dataset of various scenarios of deployment is necessary, which is obtained through simulation using the network simulator Komondor. The ML model using the Graph Neural Network (GNN) captures the deployment details and is able to converge to the throughput values being predicted closely. By tuning the hyperparameters and varying the configuration parameters the ML model is refined to produce significant improvement in the accuracy of prediction of throughput. The results can be used to build and analyze the performance landscape of densedeployed WLANs for arbitrary or systematic deployments for discovery of optimal deployment.


Objective. To evaluate the effects of various surface conditioning methods and agents. Methods. The intaglio zirconia substrates were air particle abraded with
 Al2O3 (O 50 μm) for 10 s. An air pressure of 450 kPa and a nozzle distance of 10 mm were used. Surface conditioning by groups: A = silane coupling agent


We present a broadband infrared and optical study of the compositionally complex nickel-based superalloy Inconel-718, a common material used in additive manufacturing using the direct metal laser sintering (DMLS) technique. We find a broad, featureless spectral emissivity, which is consistent with dc transport measurements and contextualize the results against literature reports of disordered metals. We show that electronic structure calculations based on first-principles modeling can explain most of the spectral weight distribution and show that the peculiar infrared optical properties in this class of materials can present challenges in accurately reporting remote temperature sensing in DMLS.


Based on the running characteristics,the experimental results show that wear particles appear on the normal running stage.The fractural characteristics of wear particles were investigated, it is found there exists a relation between the wear characters and bear conditions.


A late-stage amination of a bifunctional dihydroxanthene (DHX) scaffold is reported to access a wide variety of new near-infrared (NIR) chromophores/fluorophores. The divergent approach allows the coupling of aliphatic and aromatic amines and readily provides molecular diversity shedding light on the structure-fluorescence relationship of this emerging class of NIR fluorophores.


We comment on various aspects of topological gauge theories possessing N T ≥ 2 topological symmetry: 1. We show that the construction of Vafa-Witten and Dijkgraaf-Moore of 'bal-anced' topological field theories is equivalent to an earlier construction in terms of N T = 2 superfields inspired by supersymmetric quantum mechanics. 2. We explain the relation between topological field theories calculating signed and unsigned sums of Euler numbers of moduli spaces. 3. We show that the topological twist of N = 4 d = 4 Yang-Mills theory recently constructed by Marcus is formally a deformation of four-dimensional super-BF theory. 4. We construct a novel N T = 2 topological twist of N = 4 d = 3 Yang-Mills theory, a 'mirror' of the Casson invariant model, with certain unusual features (e.g. no bosonic scalar field and hence no underlying equivariant cohomology) 5. We give a complete classification of the topological twists of N = 8 d = 3 Yang-Mills theory and show that they are realised as world-volume theories of Dirichlet two-brane instantons wrapping supersymmetric three-cycles of Calabi-Yau three-folds and G 2-holonomy Joyce manifolds. 6. We describe the topological gauge theories associated to D-string instantons on holomorphic curves in K3s and Calabi-Yau 3-folds.


The development of synapses has been followed in Macaca monkey fetal and infant retina using immunocytochemical labeling for the transmembrane synaptic vesicle glycoprotein, SV2. Electron microscopy (EM) was used to verify the presence of morphological synapses at selected ages. EM immunocytochemical labeling in adult retina showed that all synaptic types contained SV2 in inner (IPL) and outer (OPL) plexiform layers. In fetal retina, SV2 expression and the appearance of morphological synapses were closely related in time, demonstrating that SV2 is a reliable marker for synaptogenesis.


This paper is focused on the benefits that public spending on pensions is able to
return to the Spanish economy in terms of output and employment. Thus, we offer
an alternative approach to the perspective supported in current pension reforms,
where pensioner benefits are mainly considered an excessive burden on workingage
population that eventually limits economic growth. The results of our analysis
clearly show the stabilizing effect of the expenditure on pensions during the
recession, since it has not only contributed to the economic insurance of the
retirees, but it has also helped to alleviate the negative trend in production and
employment due to the collapse in demand of the Spanish economy


Mouse hybridomas were isolated that produce monoclonal antibodies (MAbs) to several regions of the HIV envelope, gp120, which may be used to map immunogenic regions in animal and human immunity. One series of MAbs was generated by repeated immunization with recombinant gp120 (rgp120) from a single isolate, and a second series by sequential immunization with rgp120 from three isolates. All MAbs bound to rgp120IIIB, but only one bound well to cell surface-expressed gp160. Synthetic peptides spanning much of the length of gp120 were used to map MAb reactivity. Two MAbs were mapped to the C1 region, one to the C2 region, and three to the C5 region by this approach. Six distinct epitopes were detected by competitive binding analysis. One MAb binding the C1 region blocks binding of CD4 to rgp120IIIB, binds by ELISA to rgp120MN (an isolate not used during immunization), and binds to cell surface-expressed gp160. These hybridomas will be made available to the scientific community through a hybridoma culture facility.


Allophylus edulis (A.St.-Hil., Cambess. and A. Juss.) Radlk., commonly known as cocum, belongs to the Sapindaceae family. This species is of great medicinal interest, with studies showing that its fruits have antioxidant, anti-cholinesterase, and cytotoxic activity. In addition, it is used in traditional medicine as an antidiarrheal, anti-inflammatory and antihypertensive. The objective of this study was to perform somatic embryogenesis in vitro from leaf and root explants of Allophylus edulis, using different 6-benzylaminopurine (BAP) concentrations combined with naphthalene acetic acid (NAA). All treatments exhibited 100% callus formation, except for the treatment without supplementation of growth regulators. The calluses developed in treatments from leaf explants showed up to two colors (brown and brown/cream), and the highest fresh and dry mass was observed in the treatment with 0.5 mg L-1 of BAP with 0.1 mg L-1 of NAA. There was no shoot formation from the leaf explants. The callogenesis in treatments from root segments showed callus formation with up to three colors (brown, brown/cream, and cream/green), and the highest fresh and dry mass was obtained when cultivated with 2.0 mg L-1 of BAP combined with 0.1 mg L-1 of NAA. These auxin and cytokinin concentrations also showed a higher number of shoots. The interaction between auxin and cytokinin is recommended to obtain somatic embryogenesis in root segments and callus with morphological characteristics suitable for organogenesis.

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In press - Online First. Article has been peer reviewed, accepted for publication and published online without pagination. It will receive pagination when the issue will be ready for publishing as a complete number (Volume 47, Issue 4, 2019). The article is searchable and citable by Digital Object Identifier (DOI). DOI link will become active after the article will be included in the complete issue.
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This article introduces the idea of third party logistics; expounds the role of third party logistics to enterprise and society; emphasizes the government should exert important roles in policy supporting, establishing uniform management system, etc. during the development of third party logistics.


Raheb, Mitri, and Suzanne Watts Henderson. The Cross in Contexts: Suffering and Redemption in Palestine . Maryknoll, NY: Orbis Books, 2017.


Exploration of the future is an essential component of effective long-range planning. Navigating the change process is the anticipated object. The author used the Delphi technique to identify the probable future events in health care and in nursing practice, education, and education administration. Concomitant strategies required by nursing education administrators to manage future programs are identified.


Purpose Determination of the diagnostic capabilities of metadevices for breast MR examination in women. Material and methods In the study, two types of metadevices for examining the mammary glands were considered – for imaging in a field with magnetic induction of 3 T and 1.5 T. 11 healthy women of reproductive age were examined, magnetic resonance images of T1 (turbo spin echo) and T1 3D gradient echo (GRE) were obtained based on the Dixon method with fat saturation. The images were evaluated by radiologists on a 5-point Likert scale. Results The images obtained using the metadevices were characterized by acceptable and comparable absolute and relative signal-to-noise ratios comparing them to images obtained using a standard coil at the same spatial resolution and with a decrease in input power by an average of 27 times for 3.0 T. At the same time, for 1.5 T, the input power was reduced by a factor of 15.6, and the signal-to-noise ratio was increased by a factor of 2. For image quality criteria in terms of presence/absence of artifacts, the average score for the metadevice was higher than the score for the specialized coil by 3 T. For 1.5 T, this parameter turned out to be the same, which was probably associated with a lower level of artifacts by 1.5 T than by 3 T in general. Discussion Analysis of the collected assessments of independent experts indicates that the diagnostic characteristics of magnetic resonance images of the mammary glands obtained using ceramic-based (for 3 T) and wire-based (for 1.5 T) metadevices are of a good and average level, and are comparable in terms of all criteria with standard approaches. Conclusions The assessment of the quality of the obtained images demonstrates the acceptable quality of imaging and reflects the possibility of their application in clinical practice, taking into account ongoing improvements and optimization of the entire set of pulse sequences for MRI of the mammary glands.


Australodorus enigmaticus, a new genus and species of Longidoridae, is described from an area of previously uncultivated soil inside a Citrus plantation in Uruguay. The genus belongs to the Xiphidorini and is characterised by a well offset lip region, bilobed amphidial fovea with large slit-like aperture, slender odontostyle with forked base, weakly flanged odontophore and posteriorly located guide ring. Females have uteri without pars dilatata and males have the ventromedian supplements outside the range of the spicules. The tail is short convex-conoid in both sexes. The genus comes close to Paraxiphidorus and Xiphidorus but differs in the shape of the amphidial fovea. The only species so far known is a long (5-7.5 mm) and slender (a = 115-190), amphimictically reproducing form with a 1:1 sex ratio.


Qualities of the effective principal are listed here. If you need a morale boost, something to inspire, this article is for you.


This paper stresses the need for community responses to the ethnic unemployment problem in New Zealand. It aims to show the potential for direct employment creation on the basis of a community entrepreneurship model as well as a widened definition of human capital, using case study of the labour market disadvantaged community of Otara, in South Auckland. Projects harnessing cultural and ethnic riches to create Otara as an attractive visitor destination undertaken by Enterprise Otara (EO) are examined. A participatory research methodology, chiefly formative evaluation is used. ·This paper seeks to break down a prevalent view that grassroots responses to unemployment are necessarily small-scale ventures and to get away from the 'small is beautiful' mind-set when Local Employment Initiatives (ILEs) are involved. Additionally, the collaborative role of 'outsiders ' in the 'bottom-up' approach to employment creation is shown to be important in 'getting things moving ' at the community level. Constraints faced by community organisations are highlighted. The importance of ILEs and the partnership concept in the mitigation of high unemployment in disadvantaged communities, is affirmed.


Chinese cities have witnessed enormous neighbourhood changes as a result of housing reforms, rapid urban expansion and massive rural-to-urban migration. Migrants, without local hukou status, are confronted with many constraints in accessing urban housing. While previous studies have focused on migrants' poor housing conditions, relatively little is known about their self-selection into different neighbourhood types, as well as their subjective evaluation of the living environment in local areas. Drawing upon a large-scale questionnaire survey conducted in Beijing in 2013, we examine the factors influencing migrants' residential choices, in particular urban villages versus other neighbourhood types, in a multinomial logit model, and the sources of residential satisfaction in a multilevel framework. The results show that migrants sort themselves into different neighbourhoods contingent on demographic and socio-economic factors, and express different levels of satisfaction after controlling for individual attributes and geographical context. Moreover, their self-selection significantly influences residential satisfaction.


In this study, an inward turning waverider forebody/inlet axisymmetric reference flow model with a conical leading-edge shock wave was designed based on the method of characteristics. The design eliminates the lip shock wave at the shoulder point. Based on the reference flow model, a novel integrated design method for an inward turning waverider forebody/inlet is proposed. The streamline tracing method and related technologies were used to generate the integrated configuration in the reference flow model. During the design process, the inward turning inlet was divided into an upper and a lower surface. After the formation of these surfaces, the front external surface and the lip external surface were simultaneously generated. Finally, an integrated configuration was formed with these four generated surfaces and a base plane. An analysis of the formed configuration was carried out using numerical simulation software, which verified the correctness and feasibility of the method. The conclusions drawn from the research indicate that the integrated design method is feasible and effective.


By means of Pegg and Barnett phase formalism,the phase properties of the field interacting with two Λ-type three-level atoms via Raman coupling in a phase damped cavity is discussed.The influences of decay coefficient of the cavity and the intensity of the field on the phase distribution as well as its fluctuation are discussed.The results show: if there is absence of the phase damping,the phase distribution oscillates with the period π/λ.It presents single leaf at t=nπ/λ,but it splits into multi-leaf construction during the evolution period due to the interaction between the field and the atoms.If there is presence of the phase damping,the obvious leaf construction of the phase distribution become obscure and contract into a circle,which indicates the random distribution of the phase.Moreover,the larger the decay coefficient is,the more rapidly the phase becomes random distribution.The narrowing of the leaf and the increasing amplitude of the phase distribution corresponds to a stronger field.The phase fluctuation shows damped oscillatory behavior and ultimately reaches a steady value in the phase damped cavity.The time for it to approach the steady value shortens when decay coefficient increases.


A method to accelerate the design of 2-D circularly symmetric finite impulse response (FIR) filters is presented. This method utilizes the circular symmetry property and computes the elements of the impulse response using only the elements located on a half-axis in the space domain, i.e., h(m,0). h(m,n) can be computed using B-spline and piecewise Lagrange interpolation on h(m,0). When used in conjunction with nonlinear optimization, this method results in considerable reduction of execution time and lower sensitivity to the initial vector. This characteristic can be useful in higher-order filters where finding a suitable initial vector for a better local optimum becomes more difficult.<<ETX>>


Study Objective. To investigate the early blood pressure effects of vasopressin compared with titrated catecholamines as initial drug therapy in patients with septic shock.


CrAlSiN/W_2N nanolayered coatings were prepared by direct current magnetron sputtering. The modulation periods of multilayer coatings were controlled in the range from 3 to 20 nm. From the low angle x-ray diffraction and high angle x-ray diffraction (XRD) satellite peaks, the superlattice structure of these coatings was evidenced. The modulation periods of multilayer coatings were obtained precisely by the low angle XRD and high angle XRD satellite peaks methods. The detailed layered structure was further investigated by high-resolution transmission electron microscopy. Because of the dense and smooth nanolayered microstructure, the CrAlSiN/WaN multilayer films exhibited excellent microhardness. With an appropriate modulation period of 8 nm, the hardness reached a maximum around 40 GPa. The hardness enhancement is attributed to the large lattice mismatch and strengthening of superlattice structure, which is confirmed by XRD and transmission electron microscopy.


Drs. Snowe and Wilfert's1 timely paper on epidemic reappearance of gonococcal ophthalmia neonatorum calls attention to a very serious problem. Recently in Wisconsin a case of gonococcal ophthalmia was reported2 in a 3-day-old infant who received silver nitrate prophylactic treatment. The prenatal care consisted of 14 visits to an obstetrician, which did not include screening for gonorrhea.
 The author's statement in the summary "gonorrhea occurs with significant frequency in obstetrical groups to merit attempts at therapy of the gravid mother" could be misinterpreted as advocating treatment without establishing a diagnosis.


Abstract Line and screw systems, used in robotics and machinery analysis, become singular at particular geometric configurations. When not singular, measures are required that describe how far they are from being so. A new system of measures is proposed whose outcome is strictly invariant with respect to coordinate frame, origin and unit of length. Examples of the application of the new measures to sixfold systems of lines and screws in the context of work-holding systems and robotic manipulators are given.


Muslims are a growing segment of the American workforce, both in the public and private sectors. With the World Trade Center disaster, public employers are now more aware of the presence of Muslims and, perhaps, concerned about how they will be integrated into their workforce. This article provides a description of Islamic religious practices. It then reviews the role of the First Amendment, state religious freedom acts and civil rights laws as protections afforded to religious persons in the public sector. Through a review of court cases from 1994 to 2001, it describes the status of court protections for Muslim religious practice in the public workforce.


Recently, concrete has become a preferable primary raw material in construction, compares to wood and steel. However, some concrete cannot withstand heavy load; they even easily get eroded by seawater. That comes from the cement paste material used in a concrete based building structure. There are various ways to improve cement properties; one of them is by using nanomagnetic material in its production process. This study focuses on the synthesis and characterization of Fe3O4@Co3O4/Al2O3 (FCA) particle that can be composited with cement material to revive the compressive strength of the cement. Co3O4 nanoparticle and Fe3O4@Co3O4/Al2O3 nanocomposite have been successfully synthesized using coprecipitation and sol-gel methods. The Co3O4 nanoparticle and Fe3O4@Co3O4/Al2O3 nanocomposite with Fe3O4@Co3O4 core-shell mass variation was characterized by XRD. The characterization result shows a particle size of 4.9 nm. Meanwhile, the Fe3O4@Co3O4/Al2O3 nanocomposite morphology has been successfully characterized using SEM instrument. The Fe3O4@Co3O4/Al2O3 nanocomposite that tends to get agglomerated is those with an average particle size of 22.9 nm. The characterization results of Shore D in Fe3O4@Co3O4/Al2O3 nanocomposite compressive test show that a concentration increase of Fe3O4@Co3O4 core-shell significantly affects the growth of nanocomposite hardness level with an optimum value of 79.8 MPa for the highest concentration ratio. Therefore, Fe3O4@Co3O4/Al2O3 nanocomposite is a very excellent reinforcing material for cement in the construction field.


Bt products were evaluated for their effect on PLR larvae using a leaf-disk bioassay. A series of Bt concentrations ranging from 0.5 to 5 times the recommended field rates were tested. Untreated apple leaves were collected from Red Delicious trees at the WSU Tree Fruit Research and Extension Center, Wenatchee. Bt products were diluted in 500 ml of water plus 2 u,l of X-77, a wetting agent added to aid leaf wetting. An untreated control was prepared using water plus the wetting agent only. Leaves were dipped and allowed to dry. Two disks (2.3 cm diameter) were taken from each leaf. Four leaf disks were placed in a petri dish (Falcon 1006, 50x9 mm). Five one- to two-d-old leafroller larvae were placed on the leaf-disks and the petri dish lid was put in place. Ten dishes were used for each Bt product and rate (50 larvae per treatment). Dishes were placed inside a food storage container with a wet paper towel to maintain a high humidity and kept at 75°F (±2°F) constant temperature and 16:8 photoperiod. Dishes were examined after 48 and 96 h to determine larval survival. Data were corrected for untreated mortality using Abbott's formula.


We derive bounds on the integrated density of states of Schrodinger operators with a random, ergodic potential. The potential depends on a sequence of random variables, not necessarily in a linear way. An example of such a random Schrodinger operator is the breather model, as introduced by Combes, Hislop and Mourre. For these models we show that the the integrated density of states near the bottom of the spectrum behaves according to the so called Lifshitz asymptotics. This enables us to prove localisation in certain energy/disorder regimes.


An optical oxygen analyser was used in two small‐scale industrial trials to non‐destructively assess the quality of packaged convenience foods and packaging process. Beef lasagne packed under 70% vacuum and cooked under standard sous vide conditions was monitored for residual oxygen, using disposable sensors incorporated in each pack and a benchtop optical oxygen analyser. High levels of residual oxygen close to ambient were determined in the majority of packs after packaging, as opposed to anticipated levels of 4–5%. Residual oxygen was monitored over product shelf‐life (4 weeks at +4–10°C) along with measurement of microbial growth and lipid oxidation in food by conventional destructive methods. Oxygen levels in packs went down to almost zero between weeks 2 and 3 indicating deterioration of packaged product. Correlation between oxygen profiles and the rate of microbial growth and lipid oxidation was established. The optical oxygen sensor system was shown to provide valuable information about performance of the packaging process, product storage conditions and food quality in a convenient and cost‐efficient fashion and non‐destructively. Copyright © 2004 John Wiley & Sons, Ltd.


To the Editor: A 34-yr-old female presented for a surgical cure of trapezio-metacarpal osteoarthritis of the thumb. A midhumeral block was chosen because the patient feared general anesthesia and also desired postoperative analgesia. Once the needle insertion site had been located based on classical landmarks, the patient informed the anesthesiologist that an implant had been inserted in the medial aspect of her arm (1). The procedure was immediately stopped and the implant was easily palpated close to the planned needle insertion site. We then performed an axillary block which was uneventful as was the surgical procedure. Implanon is the trade name for a progesterone contraceptive implant produced by Organon. It is a single rod-shaped nonbiodegradable implant that contains 68 mg of desogestrel metabolite etonogestrel which is released for at least 3 yr after which it should be replaced (2). It has a length of 4 cm and a diameter of 2 mm and is usually inserted just under the skin in the subdermis on the medial aspect of the nondominant upper arm, 6–8 cm above the elbow. Puncture of the device by the stimulating needle might possibly rupture the implant, resulting in its dysfunction (3). The rod may not be palpable after incorrect insertion, significant weight gain after insertion, or possible migration (4,5). When confronted with the clinical management of a patient with a nonpalpable Implanon, ultrasound is accurate in detecting the absence or presence of the device with a specificity and sensitivity of 95.7% and 85.7%, respectively (Fig. 1) (6). Anesthesiologists should be alert that the implant may be present and if necessary modify their treatment plan to stay away from the device.


This paper presents a low cost MEMS variable optical attenuator(VOA) fabricated by a novel bulk-silicon micromachining technology for the optical communication applications. According to the specifications such as low insertion loss, large attenuation range, high responding speed and so on, which are demanded in optical communications for VOA, the mechanical and optical models of the designed VOA are employed for the optimization design of the structures. Performance measurements of the fabricated VOA shows that the insert loss≤0.8 dB, the attenuation range≥50 dB, the return loss≤-45 dB, the wavelength dependent loss≤0.2 dB, the polarization dependence loss≤0.25 dB and the responding time1 ms.