text: Home > HOME REMEDIES > Indigestion – Natural Ayurvedic Home Remedies Indigestion – Natural Ayurvedic Home Remedies fitblaster.com April 30, 20152015-04-30T23:43:10+00:002015-04-30T23:43:10+00:00 HOME REMEDIES 25 Comments Tweet Pin It Easy Related Posts How To Get Rid Of Constipation - Home Remedies For Constipation - EbestProducts ...read more Home Remedies for Sore Throat | Best Health and Beauty Tips | Lifestyle ...read more Tinnitus - Natural Ayurvedic Home Remedies ...read more Natural Home Remedies for Constipation ...read more How To Get Rid Of Yeast Infection At Home Fast Using Natural remedies ...read more DIY: Homemade Frizzy Hair Remedies! | AndreasChoice ...read more 25 Comments May 1, 2015 poketots Damn she is sexy meeting her just might cure me Reply May 1, 2015 mansa badman She's hot! Reply May 1, 2015 Jayaram C Shekar Merely watching this pretty woman cured 60% of my indigestion! Good job indeed!! Reply May 1, 2015 Tipu Sultan Reply May 1, 2015 christenstjohn You are so pretty :) Reply May 1, 2015 Nelson Chicas Reply May 1, 2015 karen mason If you're still struggling with heartburn go to DONEPA com for a permanent way to quickly get rid of your acid reflux symptoms Visit DONEPA com and check it out! The unit offsets the run Why does the kaput division communicate the form? The balance spearheads the money Reply May 1, 2015 Joel Munoz The home remedies r just hard to chuck down cause they tast like piss Reply May 1, 2015 gurlfromheaven awesome!…. Reply May 1, 2015 Homeveda - Home Remedies for You! Thank you for both your compliments! Do hit the like button on the video, to help spread the word. Reply May 1, 2015 Homeveda - Home Remedies for You! Yes Reply May 1, 2015 Organico G beautiful dress !!! Reply May 1, 2015 Kay C My face book name is Karen Cutrer Corkern !! Please add me I'm here for you:))) Reply May 1, 2015 phersotty hi, I have suggestion/request for your website… can you provide a grocery shopping list and maybe a glossary of terms for example, I am quite familiar with what garlic is but jaggery on the other hand, I am completely unfamiliar with. Also some background videos would be great too for example when milk is used in a remedy, should whole or skim milk be used? Thanks for the great videos. Reply May 1, 2015 SANAM'S Kitchen Yes you deserve a treat. so i am spreading a word around and telling all my friends n family about your remedies /sharing a link. keep it up! Reply May 1, 2015 Dara M Can this help in case of chronic gastritis ? :/ Reply May 1, 2015 SANAM'S Kitchen Very nice and easy tips. Also your dress is really pretty. Reply May 1, 2015 Homeveda - Home Remedies for You! Good to know you found the remedies useful! Hope you've checked our facebook page as well Reply May 1, 2015 Homeveda - Home Remedies for You! Have you checked the video on gastritis. You may want to use the remedies mentioned there. Take care. ! Reply May 1, 2015 Kay C Sanjeet Singh don't kill yourself please! I suffer from a lot if ailments including degenerative disc disease! Complex migraines which put me in icu for 4 days because it mimics a stroke. Etc and there is no cures for any of them! I could pass out at any time so now I can't drive! I know it's hard believe me! But take each day as they come good or bad and pray!:)) you may add me as a friend if you need to talk! Reply May 1, 2015 Homeveda - Home Remedies for You! You're welcome! Hope you've checked our Facebook page as well! Reply May 1, 2015 Homeveda - Home Remedies for You! Hi.. thank you.. have you checked this – homeveda.com/sleep-disorders/natural-ayurvedic-home-remedies-for-insomnia.html Reply May 1, 2015 Ydontyou Fvckoff you guys have belly ache too? Reply May 1, 2015 SANAM'S Kitchen Hello, I was suffering from indigestion and tried one of your remedy from this video. The one "buttermilk and coriander juice" and it worked really well. I tried it for a week to give you and honest feedback. And it really works. No more heartburn. Thanks for posting your remedies. Reply May 1, 2015 khadija malick LOL Reply Leave a Reply Cancel reply Your email address will not be published. Required fields are marked * Name (required) Email (required) Website Related Posts Homemade Cough Syrup: Natural Home Remedies for Persistent Coughs Natural cough remedy, soar throat and fever: antibiotic Cough – 3 Effective Natural Home Remedies To Get Quick Relief Simple Home Remedies for Constipation Part 2.wmv Best Acne Scar Treatment – How to Get Rid of Acne Fast With Home Remedies Skin Care – Blackheads – Natural Ayurvedic Home Remedies Natural Foot Pain Cure – Home Remedies How to INSTANTLY STOP A TOOTHACHE at home remedy


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Metallic Bubblegum Hair Color Takes Pink Hair To The Next Level
Launching this weekend @cosmoprofna @prorituals is unveiling 9 NEW SHADES!! The metallic collection is happening! Stay tuned for more details and how to get your hands on them! Hair by: Doug Martucci, Mikki Lilles, Nicole Emiliani. Make up:Doug Martucci photography:Doug martucci #prorituals #proritualscolor #certifiedcolorist #bubblegumhair #americansalon #hairbrained #photography #hairnerd #hairstylist #pastelhair #metallichair
Pretty much every shade of rainbow hair is stunning. That's part of the reason why there are so many different hair color trends and they are all so varied. Out of all of the shades in the rainbow, pink hair might just be the favorite. We've seen everything form salmon sushi hair to beloved rose gold, and now we have metallic bubblegum hair.
(Related: LORAC Is Launching Three New Unzipped Palettes)
Metallic bubblegum hair combines two of our favorite things: pretty pastel hair colors and a metallic finish.The result is a prismatic dye job that will allow you to unleash your inner unicorn.
If you're wondering how metallic bubblegum hair separates itself from the countless other pink hair trends, especially its cousin rose gold, the difference is that the soft metallic pink is combined with tangerine on a soft grape base. Doug Martucci, Creative Director at ProRituals, explained to The Gloss about how metallic bubblegum hair has a distinct look:
"Traditional pink tends to be more vibrant and more intense, meaning the hair can also be darker before you apply the pink. Traditional Pink can be very flat in nature when it comes to the reflection and almost opaque whereas a metallic will exhibit tones that have an almost patina effect in the hair. In order for this to happen the hair has to be pre-lightened to a very pale blond first and usually pre-toned with a violet shade to remove any unwanted warmth prior to applying one of these shades. In order to achieve this look multiple shades are used. Start with a strong base color in the bubble gum of your choice, just like bubblegum it's fun. Alternate strands of color and have fun melting two to three shades down the strands to create a unique distinct reflection."
Another great thing about the metallic dye job is that the different warm tones in it help bring out golden tans.
(Related: If You Love Rainbow Hair, You're Going To Want To Know About Color Misting)
If you want to try out the trend, you're going to need to be prepared for a few visits to the salon until you have light enough hair to apply the grape, tangerine and pink tones to. And like a lot of rainbow hair colors, this one will require some maintenance. Hair should definitely be treated with color-safe hair products, and you'll have to hit the salon regularly to keep your metallic bubblegum hair looking, erm, bubblegum-y.

subset: commoncrawl


text: Open School of Journalism Open School of Journalism https://www.openschoolofjournalism.com/c/blogs/find_entry?p_l_id=13658 2018-09-26T15:34:16Z 2018-09-26T15:34:16Z Producing New Module Videos Author https://www.openschoolofjournalism.com/c/blogs/find_entry?p_l_id=13658&entryId=262420 2017-07-17T10:04:33Z 2017-07-17T10:03:00Z Today we start with the production of new module videos. Some interesting modules coming up in video format soon! Author 2017-07-17T10:03:00Z Quote of the Day Author https://www.openschoolofjournalism.com/c/blogs/find_entry?p_l_id=13658&entryId=262429 2017-07-17T10:10:10Z 2017-07-14T14:28:00Z "The less you know, the more you believe!" Author 2017-07-14T14:28:00Z Quote of the Day Author https://www.openschoolofjournalism.com/c/blogs/find_entry?p_l_id=13658&entryId=262437 2017-07-17T10:09:48Z 2017-07-10T00:17:00Z "The only writer to whom you should compare yourself is the writer you were yesterday." (David Schlosser) Author 2017-07-10T00:17:00Z Journalistic Investigation Author https://www.openschoolofjournalism.com/c/blogs/find_entry?p_l_id=13658&entryId=262445 2017-07-17T10:14:14Z 2017-06-13T17:11:00Z Our course module on Journalistic Investigation is available in video format now: Author 2017-06-13T17:11:00Z Quote of the Day Author https://www.openschoolofjournalism.com/c/blogs/find_entry?p_l_id=13658&entryId=262468 2017-07-17T10:15:00Z 2017-06-12T10:14:00Z "The function of a good journalist is to take information and add value to it." (John Chancellor) Author 2017-06-12T10:14:00Z Distance Learning Facts # 4 Author https://www.openschoolofjournalism.com/c/blogs/find_entry?p_l_id=13658&entryId=249878 2017-05-26T12:37:12Z 2017-05-26T12:36:00Z "Compared to traditional education, online degree programs, courses, and boot camps focus much more on teaching hard and specific skills that will get you a job. [...] you'll be practicing for tasks Author 2017-05-26T12:36:00Z Fellowships: "Climate & Energy Policy", "Foreign & Security Policy" and "Democracy & Social Policy" Author https://www.openschoolofjournalism.com/c/blogs/find_entry?p_l_id=13658&entryId=244954 2017-05-05T10:47:41Z 2017-05-05T10:47:00Z Heinrich Boell Foundation North America, a German political foundation, funded a fellowship that we'd like to draw your attention to. The fellowship and supports journalists in conducting a certain Author 2017-05-05T10:47:00Z Journalist Privacy Guide Author https://www.openschoolofjournalism.com/c/blogs/find_entry?p_l_id=13658&entryId=240775 2017-04-18T13:46:01Z 2017-04-18T13:44:00Z This is not an easy time for journalists all over the world, with the discoveries of surveillance on citizens, which includes journalists and their sources. We'd like to share a guide, written by a Author 2017-04-18T13:44:00Z Quote of the Day Author https://www.openschoolofjournalism.com/c/blogs/find_entry?p_l_id=13658&entryId=237775 2017-04-12T09:52:26Z 2017-04-12T09:52:00Z "A good newspaper, I suppose, is a nation talking to itself." (Arthur Miller) Author 2017-04-12T09:52:00Z Quote of the Day Author https://www.openschoolofjournalism.com/c/blogs/find_entry?p_l_id=13658&entryId=237768 2017-04-06T09:51:36Z 2017-04-06T09:51:00Z "Journalism is about results. It's about affecting your community or your society in the most progressive way." (Anas Aremeyaw Anas) Author 2017-04-06T09:51:00Z


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Researchers from a number of institutes of the Bulgaran Academy of Sciences (BAS) spoke out against reforms under way in the Academy at a press conference Sunday.
They protested at the way reforms are conducted and criticized the concentration of power in BAS's central executive board, calling for more autonomy of institutes.
The academics said that pressure for reform exerted by the current Bulgarian government on the BAS is being used by the central board to entrench its power and manipulate institutes.
Nikolay Aretov from the Institute of Literature called for more transparency in the Academy, including in fiscal matters. The researchers joined in demanding a new Statute for the organization.
Angel Stefanov from the Institute of Philosophy spoke out against proposed mergers of institutes intended to optimize the academy's structure and to cut down spending. According to him, mergers are done by force, without consulting scientists themselves and to the detriment of research.
At the same time, Krassimir Kanev, chair of the Bulgarian Helsinki committee characterized the methods of the reform as corrupt, because it is arbitrary, and without taking into account the recent international evaluation of the Academy and its institutes. According to Kanev the reform can lead to breach of rights of those working at BAS.
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Bacteria are microscopic organisms that have the capacity to infect our body. Although most bacteria do not create harm in our body, those that do may develop into diseases, ones that create discomfort or even death. If you develop a bacterial infection, it is important that you provide treatment for your infection as some infections have the capacity to worsen, or worse, spread towards other body parts. If you have such an infection, the use of antibiotics will be the key in helping you get rid of the infection you have developed.
There are many ways on how you can acquire an infection. Some contagions can be gotten through touch, and some can be gotten by simply being in the place where there is a contagion. On either case, you will need to remedy your infection issue to ensure that it does not worsen. If you fail to treat the infection that you have, its treatment will be more difficult as well as costlier. The reason is that you need to use more antibiotics to purge the infection as more days of treatment will be needed to ensure that the contagion inside your body has been completely dealt with.
Antibiotics did not exist in the past, and thus the reason why many people then succumbed to simple bacterial diseases. It was only when penicillin was discovered by Alexander Fleming that antibiotics became known to men. Penicillin was the first antibiotic, which was soon followed by many – either new or a derivative or engineered form of penicillin. The efficacy of each antibiotic differs. Even so, most antibiotics are able to treat different types of bacterial infections, provide the treatment directions given by the doctor are followed. Antibiotics are a necessary existence for us because they help us to exist and live our lives longer. Without antibiotics, it is likely that many of us will die from simple bacterial infections.
If you develop a bacterial infection, the best way to get antibiotics is to buy antibiotics online. These days, you can buy antibiotics online or you can buy them from a regular drugstore. However, if you want to make some savings, you may want to buy antibiotics online because the prices of antibiotics and other meds online are simply much lower. This is the reason why more and more people who need such treatment drugs buy antibiotics online.
It is necessary for anyone infected with bacteria to treat their infection as soon as possible. In the past, such immediate treatment was not possible when buying antibiotics online. These days, online merchants have found a way to deliver online purchases fast. If you buy antibiotics online, you can take advantage of this fast delivery service. When you do, you can expect to receive the products you purchased by the very next day. No wonder many have now considered to buy antibiotics online, especially since you can save a lot of money if you buy antibiotics online. It can be said that there is nothing better than getting the products you need for a significantly lower price.


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Rising young stallion Medaglia d'Oro, sire of Kentucky Oaks and Preakness Stakes winner Rachel Alexandra, has been acquired by Sheikh Mohammed bin Rashid al Maktoum's Darley operation and relocated to Jonabell Farm.
Medaglia d'Oro had been owned by Audrey and Richard Haisfield's Stonewall Farm, where he stood this past year for $60,000. Terms of the deal were not disclosed.
"Sheikh Mohammed has been following Medaglia d'Oro's stud career with great interest and has been most impressed not only by the likes of Rachel Alexandra and many other exciting prospects in his first crop, which are now 3-year-olds, but also by the quality of yearlings that we have seen at public auction," John Ferguson, Sheikh Mohammed's bloodstock adviser said in a statement. "Sheikh Mohammed believes that Medaglia d'Oro has a very exciting future ahead of him."
Medaglia d'Oro stood his first season at stud at Hill 'n' Dale Farm in 2005 before shifting to Stonewall the following year. An earner of more than $5.7 million on the track, the 10-year-old son of El Prado is the leading second-crop sire to date this year with seven stakes winners from his two crops.
"We felt we had to do right by him," said Richard Haisfield. "He has been so good to us, and this was the opportunity of a lifetime for him. Darley has the ability to make him an international sire."
No stud fee has been announced for 2010.


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Group Guess - 80s and 90s Taboo-Like Game 5.2
This is like the game Taboo, but with words associated with the 80's and 90's. Can you get your team to guess Teenage Mutant Ninja Turtles without saying Green, Cartoon, Martial Art, Raphael or Donatello?
To play, groups should be divided into two teams. Team A selects a clue giver from their team who will attempt to get his or her team members to guess the main word at the top of each card without using any of the forbidden words...


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It's always nice to have themes on your house, bedroom, living room or garden. You will need some design ideas to decorate your house. If you want to know more about brilliant bedroom design ideas, then you have come to the right place. Picking your bedroom design is the most interesting to do. Pick your favorite color, theme, furniture or design ideas to build your dream bedroom. Before choosing a bedroom design, you will need to pick your theme on your bedroom. Do you like minimalistic theme? or you want classic but modern touch? You need to pick your theme before buying, bed frame, furniture, bed cover or bedroom design. Having a theme in your bedroom will make your bedroom more harmonious and elegant. Choose your favorite theme, or if you confused in choosing your theme, you can ask an interior designer opinion. They are expert in home interior, decoration, furniture and room design.
What We Need To Know In Choosing Bedroom Design Ideas?
Before choosing your bedroom design ideas, you need to consider many things. First of all, consider your bedroom space. Space is important in order to know how many furniture's you can put in your private room. If you have tiny space, then you can't put a lot of furniture there. You also should consider wall space. You can put wall decoration such as paintings, mirror or any other decorations on the wall, but don't put too much wall decorations.
Next, you should consider Plan, theme, and design. Just like mentioned above, it's always good to have theme and planning for your room. Plan your design for your house, adjust it to have balanced theme. Then you should also plan on your budget. This is quite important, especially if you are tight on your budget. You need to consider choosing inexpensive furniture. Big budget maybe can give you a lot of furniture, but it doesn't mean it can give you the most beautiful and tedious room. If you want to know more design for your bedroom, visit http://beninbrown.com right now.


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Maxillofacial surgeons bring unique set of skills to elective cosmetic surgery
A growing number of oral and maxillofacial surgeons (OMSs) are taking their training and experience in facial trauma and reconstruction into the elective cosmetic realm as age-conscious Baby Boomers seek remedies for their drooping eyelids and developing jowls, according to surgeons who will speak at the American Association of Oral and Maxillofacial Surgeons (AAOMS) 85th annual meeting, September 10-13, in Orlando, Fla.
"Cosmetic surgery now represents about 10 to 20 percent of our specialty, and that percentage will increase as Baby Boomers continues to age and the demand for cosmetic surgery continues to grow," says Jerry L. Jones, D.D.S., M.D., an Albuquerque, NM, oral and maxillofacial surgeon and an associate attending physician in the Division of Plastic and Reconstructive Surgery at the University of New Mexico. Dr. Jones will moderate a symposium on soft tissue cosmetic procedures at the AAOMS meeting.
The escalating demand for cosmetic services in the United States is fueling a growth in the number of cosmetic surgery fellowships offered to OMSs and other specialists through such organizations as the American Academy of Cosmetic Surgery, he says.
In addition, Dr. Jones believes the increase in OMS involvement in facial cosmetic work reflects a broader overlapping of anatomic boundaries among the various medical and dental specialties over the past 10 to 15 years.
Their unique combination of dental and surgical training provides OMSs with a natural affinity for cosmetic reconstructive surgery. OMSs are the leading experts in orthognathic surgery, the surgical repositioning of the upper and lower jaws to achieve facial balance and other functional problems, such as breathing and chewing. They are often the first surgeons called into the hospital emergency room to assist in cases involving facial trauma.
Although orthognathic surgery still represents a significant portion of what OMSs do, "OMSs have become more soft tissue-conscious in recent years, while plastic surgeons have become more bone-conscious," Dr. Jones says.
"The anatomic definitions of the specialties are no longer as rigid as they once were. That is a good thing, because traditional anatomic boundaries are not what matter most. What matters are training, experience and competency," he says.
As the first on-call specialists in emergency rooms for patients with facial trauma and as experts in the surgical correction of congenital facial deformities, OMSs have a deep understanding of facial structure and harmony. Their knowledge and experience prepare them very well for the facial cosmetic arena, Dr. Jones says.
It was an OMS, in fact, who pioneered one of the most important recent advances in facial cosmetic surgery, Dr. Jones notes. The technique, known as the four-dimensional facelift, represents a significant improvement over conventional surgical procedures, which primarily lift and tighten the skin from the outside.
Developed by Stephen Watson, D.D.S., M.D, of Plano, Tex, who will speak at the symposium, the four-dimensional facelift repositions and lifts all four layers of facial tissue, producing more attractive, natural and enduring results. The surgeon manipulates the skin, the subcutaneous layer (tissue immediately under the skin surface), the facial muscles, and the periosteum, the membrane of nerve- and blood-rich tissue covering the bones. Laser skin resurfacing can be performed at the same time to reduce wrinkling.
Other key advances in soft-tissue cosmetic surgery to be highlighted at the symposium include the use of endoscopy, which allows surgeons to see and manipulate the facial soft tissues by entering through small incisions near the hairline.
Conventional techniques involve the manipulation of tissue just under the skin. Endoscopy allows the surgeon to go deeper and to manipulate and tighten facial tissue by elevating tissue off of the bone, producing a younger, fresher appearance.
The surgeon places a small, wand-like instrument called an endoscope through an inch-long incision. A tiny camera in the scope sends a real-time image to a video monitor. Using the video display as a guide, the surgeon inserts small instruments through the other incisions to lift and reposition tissue to achieve the desired results.
This less invasive approach preserves more facial blood supply than conventional techniques involving larger incisions; reduces scarring, bruising and postoperative pain; speeds healing; and produces more natural, lasting results.
In addition to four years of postgraduate dental education, OMSs complete a minimum four-year hospital-based surgical residency, rotating through other services, including internal medicine, anesthesiology, general and plastic surgery, and emergency medicine.
"Our dental, medical and surgical training allow us to approach facial cosmetic surgery from the bone up, and our experience in the treatment of trauma and congenital deformities gives us a solid grounding in the surgical improvement of facial appearance," Dr. Jones says. "So much of what OMSs have done traditionally has focused on making faces look better. Our expanding involvement in elective cosmetic procedures is a natural progression."


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i'm back folks. sorry for my hiatus from the blog! i decided to take a blogging break last week as i spent most of the week in tennessee with my family celebrating the life of my papaw. it was a nice break and good to unplug for awhile.
however, just because i've been silent doesn't mean things haven't been happening. i feel like there's been a lot going on recently but maybe that was just because of the unexpected trip to tennessee left me feeling a little off my game and frazzled. anyways, once again i'll give you an update on things but in bullet form {because i'm lazy like that!}:
- we have finally decided on a first name for our daughter!! yep, you read that right :) ryan and i did come to a consensus finally for this little princess! more details to come later because we are still
arguingdeciding on a middle name...
- i have been feeling quite discouraged about our wait for an embassy appointment the last week or so. i know that our agency is doing a great job and is on top of things, but i hate all the red tape that is keeping us from our son. {ahem...the US government.} i was especially discouraged because i really want to go to pick our little man up, but the more weeks that tick by, the less likely i'll be able to travel because of my pregnancy. if you think of it, will you please pray that we'd get filed for an embassy appointment soon so that we can still travel in february?? we've heard that we are currently still waiting to get our little guy's new passport back and get his physical done so that we can be filed. our agency has 2 dates at the embassy in february for visa interviews {which is what we are waiting to appear at} - the 9th and the 23rd. i'm thinking that the 9th is pretty unlikely, so we're hoping and praying for the 23rd. {plus, that would put us coming home right around or on ryan's birthday and i can't think of a better gift!}
- i'm currently in my 23rd week of pregnancy and all is going well. i can't tell you the difference that 6 weeks has made! no more nausea, constant feelings of hunger, and other not so fun side effects, and i'm soooo grateful. today i had a doctor's appointment and got to hear our little girl's heart beat again. it never gets old! according to our doctor, she is healthy and progressing along nicely. plus, i got a chance to discuss the possibility of traveling to ethiopia in march in case we can't get a february embassy date. our doctor is hopeful that i would be able to travel if we didn't get the february embassy dates, as long as our embassy date was in early march sometime. we'll see!!
- my sweet husband completed his first seriously manly project last night...a platform bed from scratch! {ok, i think my brother-in-law mostly built it but ryan definitely helped.}the boys built the bed for an extra mattress set we have that i'm putting in our soon-to-be playroom. all our other guest rooms are filling up with cribs or offices, so we were in need of somewhere to put adult guests when we have them. i thought it would be fun to have a platform bed in the playroom so it could also double as a reading nook for our kiddos as they get bigger. when the bed is moved from my parent's barn to it's new home in our playroom, i'll post some pictures.
- we finished up registering for baby gifts this weekend and that was really fun! who knew picking out stuff for little munchins could be so fun :) i especially loved being able to register for all the cute pink and frilly stuff as well as the blue and manly stuff...the best of both worlds! i have my first shower this weekend thrown by my wonderful church friends for both of our incoming children and i'm really excited. i would love nothing more than to be able to celebrate the news of being filed for an embassy date with them too! i can't wait to bring greer home to introduce him to all the wonderful ladies of fellowship who have been praying for his homecoming for months now.
ok, that's enough for now! i'm tired and need a computer screen break. thanks for checking in on me :) i hope you have a great monday evening!


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Inclusions containing α-synuclein are considered the major pathologic hallmark of a subgroup of neurodegenerative diseases, including Parkinson's disease (PD) and Lewy body dementia. In these so-called synucleinopathies, α-synuclein (normally a tetrameric soluble protein) appears as oligomers and aggregates. Point mutations or gene multiplications of α-synuclein are associated with familial forms of synucleinopathy. α-Synuclein is mainly localized in presynaptic terminals in the brain and is thought to play a key role in synaptic functions. It has become widely accepted that abnormal α-synuclein metabolism plays a key role in the neurodegenerative processes in synucleinopathies. Although the precise underlying mechanisms remain unknown, protein misfolding and dysfunction of the ubiquitin–proteosome pathway, facilitated by age-related mitochondrial dysfunction and oxidative stress, are thought to be involved in α-synuclein pathogenesis.
Formation and accumulation of toxic aggregates in cells are controlled by molecular chaperones that either refold or promote degradation of misfolded proteins by the ubiquitin–proteosome pathway. Heat shock proteins (HSPs) are the most prominent molecular chaperones controlling neurodegeneration-related aggregates. In particular, HSP70 has been shown to reduce the number of α-synuclein aggregates (Klucken et al., 2004). Transcription of HSP70 under heat shock conditions is controlled by heat shock factor 1 (HSF1), which must be deacetylated before it can bind and activate the hsp70 promotor (Westerheide et al., 2009). Sirtuins are NAD-dependent deacetylases that are thought to effectuate the deacetylation of HSF1 in the heat shock response.
Donmez et al. (2012) hypothesized that SIRT1, a sirtuin that suppresses β-amyloid production and tau protein aggregation (Min et al., 2010), might also be involved in the HSF1-HSP70-mediated reduction of α-synuclein aggregation. They studied the role of SIRT1 in α-synuclein aggregation and neuroprotection using the following three strains of transgenic mice: (1) mice with an A53T mutation in the α-synuclein gene, a mutation also found in familial cases of PD; (2) mice overexpressing SIRT1; and (3) mice with brain-specific knockout of SIRT1. By crossing these strains, they obtained A53T mice, which either had SIRT1 overexpression or lacked SIRT1 activity in the brain. A53T mice overexpressing SIRT1 had a significantly longer lifespan than A53T mice, whereas A53T mice lacking brain SIRT1 activity had a significantly shorter lifespan, indirectly suggesting that SIRT1 may be neuroprotective.
Immunohistochemical analysis revealed the presence of α-synuclein aggregates in the cortex and the brainstem of A53T mice starting from 2.5–3 months of age; no α-synuclein aggregates were detected in wild-type mice. The number of α-synuclein aggregates was significantly lower in adult A53T mice overexpressing SIRT1 and significantly higher in A53T mice lacking SIRT1, compared with A53T mice. This suggests that SIRT1 reduces α-synuclein aggregate formation in brain of A53T mice.
To examine whether HSF1 deacetylation and subsequent HSP70 expression might be the underlying mechanism in SIRT1-mediated α-synuclein aggregate reduction, Donmez et al. (2012) analyzed whole-brain extracts of the different transgenic mice strains. Acetylation of HSF1 in A53T mice was significantly elevated compared with wild-type mice. However, A53T mice that overexpressed SIRT1 showed deacetylation of HSF1, reaching wild-type HSF1 acetylation levels. Since there is little acetylation in wild-type mice, mutated α-synuclein seems to be the trigger for HSF1 acetylation. Moreover, whole-brain HSP70 RNA levels were significantly increased in A53T mice overexpressing SIRT1 and significantly decreased in SIRT1-null A53T mice relative to A53T controls.
Next, Donmez et al. (2012) investigated the interaction between SIRT1 and HSF1 in more detail, and subjected mouse embryonic fibroblasts (MEFs) from wild-type mice, from SIRT1 overexpressing mice, and from SIRT1 knock-out mice to heat shock. Analysis of the immunoprecipitated protein complexes from cell lysates revealed that SIRT1 bound to and deacetylated HSF1 only after heat shock, suggesting that an interaction between these two proteins can only occur under such stress conditions. MEFs that overexpressed SIRT1 had significantly lower levels of HSF1 acetylation after heat shock than wild-type and SIRT1 knock-out MEFs. Consequently, and also only in response to heat shock, SIRT1-overexpressing MEFs had higher levels of HSP70 protein than wild-type MEFs.
Finally, Donmez et al. (2012) studied α-synuclein aggregate-related toxicity and the role of SIRT1 in H4 cells, a human neurogliomal cell line that conditionally expressed A53T α-synuclein. Induction of A53T α-synuclein expression resulted in increased cell death after 48 h. Overexpression of SIRT1 or HSP70 decreased toxicity, whereas silencing SIRT1 or HSP70 increased toxicity. SIRT1 overexpression in HSP70-silenced H4 cells resulted in a smaller increase in toxicity. These data suggest that SIRT1 and HSF1 use the same pathway to decrease A53T-associated toxicity.
In summary, Donmez et al. (2012) showed a link between SIRT1-mediated deacetylation of HSF1 and A53T α-synuclein. They demonstrated that SIRT1 deacetylates HSF1 in neurons stressed by the presence of mutated α-synuclein and subsequently deacetylated HSF1 activates HSP70 transcription, and that increased levels of HSP70 subsequently are accompanied by a reduction in α-synuclein aggregate formation. Donmez et al. (2012) concluded that SIRT1 protects neurons against α-synuclein aggregate-associated toxicity via HSP70 and, therefore, that SIRT1-activating drugs may be effective in neuroprotective therapies.
Although the results of Donmez et al. (2012) support their conclusion, it is still possible that other heat-shock proteins are involved in the neuroprotective effects of SIRT1. They focused on expression of HSP70 because several studies have suggested involvement of HSP70 in aggregation reduction (Klucken et al., 2004). However, another study was unable to demonstrate a beneficial effect of HSP70 in mice with α-synucleinopathy (Shimshek et al., 2010). Furthermore, Westerheide et al. (2009) showed that SIRT1 influences expression of other heat shock proteins, for instance HSP27, which has protective activity too (Beere, 2005).
Moreover, the therapeutic value of reducing α-synuclein aggregates is also uncertain, given that the role of large aggregates as the key cell pathogenic mechanism of α-synuclein is still debated. Several studies have shown that oligomeric α-synuclein molecules may cause toxicity by perforating mitochondrial membranes (van Rooijen et al., 2010). Other studies even imply that α-synuclein aggregation might be cytoprotective (Takeda et al., 2006). Although Donmez et al. (2012) report the correlation of SIRT1-mediated α-synuclein aggregate reduction with prolonged lifespan, no clear evidence for a causal relation among α-synuclein aggregate formation, cell loss, and shorter lifespan was shown. Other mechanisms besides the presence of large α-synuclein aggregates may have accounted for cell loss and the reduction in lifespan, and accordingly SIRT1 may have had a different effect.
It is also important to note that SIRT1 has a wide range of targets and is involved in numerous cellular processes and functions. Examples include regulation of energy metabolism, cellular stress resistance, circadian clock rhythm, tumor suppression, and tumorigenesis (Finkel et al., 2009). Not all pathways regulated or featured by SIRT1 are completely understood. For example, only recently it was found that SIRT1 may deacetylate histone methyltransferases and histone proteins, and thereby regulate epigenetic silencing and chromatin modification (Finkel et al., 2009). Moreover, it has become clear that SIRT1 does not exert its effects only by deacetylating target proteins: SIRT1-mediated neuroprotection in cerebellar granule neurons is independent of deacetylation (Pfister et al., 2008). Thus, the effects of SIRT1 either on the reduction of α-synuclein aggregate formation and/or lifespan extension in mice expressing mutated α-synuclein may have been the consequence of SIRT1 actions mediated via other pathways.
Finally, the proposed activation of SIRT1 as a possible therapeutic strategy in the treatment of α-synuclein aggregation still needs further investigation. If SIRT1 activation is to be incorporated into an effective therapy, one must first find ways to avoid potential side effects. Indeed, SIRT1 overexpression had a protective effect in the study of Donmez et al. (2012). Li et al. (2008), however, described that SIRT1-inhibition can be neuroprotective by reducing IGF-I/IRS-2/RAS/ERK1/2 signaling. Furthermore, SIRT1 overexpression in mouse forebrain was seen to disturb lipid/glucose metabolism and motor function (Wu et al., 2011). In other non-neuronal cell types, SIRT1 overexpression may induce many more unexpected side effects.
In conclusion, the study of Donmez et al. (2012) has extended the well described cellular multifunctionality of SIRT1 with a role in the reduction of α-synuclein aggregation in neurons that were stressed by the expression of mutated α-synuclein. However, it is crucial to examine in detail how this SIRT1 action actually protects the neurons and leads to the elongation of the lifespan of mice carrying the mutated α-synuclein gene, before it can be considered for neuroprotective drug development.
Editor's Note: These short, critical reviews of recent papers in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to summarize the important findings of the paper and provide additional insight and commentary. For more information on the format and purpose of the Journal Club, please see http://www.jneurosci.org/misc/ifa_features.shtml.
We thank Dr. J. C. V. M. Copray for his advice and assistance.
- Correspondence should be addressed to Mirjan van Dijk, Laan van de Vrede 99, 9728 CE Groningen, The Netherlands. m.van.dijk.31{at}student.rug.nl


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"Fran has always been readily available, and extremely helpful in her direction. My son has benefited greatly from her experience and expertise. If there were ever one person I would go to for advice regarding my son, it would be Fran. Kim – Fort Worth, TX
Fran used input from everyone in the family to create a visual behavior plan and basic visual routines for my son. It has greatly reduced the friction and arguing, because he knows what will happen next as long as everyone sticks to the plan. It's allowed me to take a step back from the constant discipline and just be Mom.
Christine – Dallas, TX
Without Fran, I would have been even more unsure of what to do about Nikki's education. Autism is on the rise. Most people hear about it, read about it, or even know someone who has autism. As with any disability, no one really knows what it's like until they live it. Early intervention is key! (Thank you, Fran!) Dana – Joshua, TX
Fran has helped our family in so many ways. At one point my son would not enter a bathroom…any bathroom, as my husband had gotten some soap in his eyes during a bath. Over a six week period, Fran developed and implemented a stair-stepped program to get him in the bathroom and eventually back in the bathtub. Her knowledge and personal experience in dealing with Autism is astounding and allows her to not only help with specific issues families are facing, but also point out other areas that may need work before a problem arises. She has experience with several different therapeutic routes (from ABA and specialty diets to picture schedules and choice boards) and is an incredibly valuable asset for any family dealing with Autism.
Robyn – Aledo, TX
Fran's been working with me and Jayme for the past few weeks and she is the greatest. I spent the past few years read book after book and I still don't always know what to do to help my son. Fran came into my life taught me and she showed me how to take just one social story I had written and brake it down in to three different ways. I said to myself, "no wonder of my charts or stories weren't working. I was confusing my son". She has helped me get more organized,and rewrite a new school schedule. Fran hasmade a difference for my son and I. We now have a great schedule that is working and he is more successful using it. Thank you.
Mary – Godley, TX


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"This Changes Everything"
a documentary based on the book by best-selling author Naomi Klein
Free Community Screenings:
Thursday 26th Nov, 7pm @ Mudgee Uniting Church, Mortimer St
Friday 27th Nov, 7pm @ St James Anglican Church, Rylstone
in advance of the People's Marches of 29th Nov and the UN Climate Change talks of early December, come and consider these world and history-changing issues
What if confronting the climate crisis is the best chance we'll ever get to build a better world?
This Changes Everything is an epic attempt to re-imagine the vast challenge of climate change.
Directed by Avi Lewis, and inspired by Naomi Klein's international non-fiction bestseller This Changes Everything, the film presents seven powerful portraits of communities on the front lines, from Montana's Powder River Basin to the Alberta Tar Sands, from the coast of South India to Beijing and beyond.
Interwoven with these stories of struggle is Klein's narration, connecting the carbon in the air with the economic system that put it there. Throughout the film, Klein builds to her most controversial and exciting idea: that we can seize the existential crisis of climate change to transform our failed economic system into something radically better.
The extraordinary detail and richness of the cinematography in This Changes Everything provides an epic canvas for this exploration of the greatest challenge of our time. Unlike many works about the climate crisis, this is not a film that tries to scare the audience into action: it aims to empower. Provocative, compelling, and accessible to even the most climate-fatigued viewers.
This Changes Everything will leave you refreshed and inspired, reflecting on the ties between us, the kind of lives we really want, and why the climate crisis is at the centre of it all.
More information: Graeme Gardiner 0428 757369 or visit http://thefilm.thischangeseverything.org/


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We are very proud of our sistren K-Boogie (@kboogs for you Twitter heads) and her BoogieWear line.
Showing some support and hoping you Lost Angels of the West will come out and support.
Check out what the sista puts together HERE
If you can make it to the event and have a chance to own a piece of BoogieWear for your self… kudos!


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..Except the fact that when I as looking at these two trade magazines published from two different parts of the world (Auto Monitor - India & Automotive News - US), they looked like lost cousins!
Friday, June 20, 2008
What's in a magazine cover? Nothing..
Rajesh Kumar की प्रस्तुति, June 20, 2008
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Join the Conversation
To find out more about Facebook commenting please read the Conversation Guidelines and FAQs
Coffee ritual important to family, friends
Every morning, Alex Alemu, Tibereh Hidru and Aleganesh (Hannah) Habtgabr do a coffee ceremony. Roast and grind their own coffee beans. In Ethiopia, every family does this three times a day at breakfast, lunch and dinner.


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Please visit our "Contact Us" page for phone and email information. You may either contact us directly or simply fill out our contact form with your inquiry, also located on the"Contact Us" page. Once you contact us, Bella Strings will check the availability of our ensembles and provide you with a current quote list for your event. As pricing is determined by style, duration and date of event, it is beneficial to provide as much information as possible including, date, time, location, type of event and the type of ensemble requested. We look forward to hearing from you!
Your date is confirmed upon receipt of the contract and deposit. The amount of the deposit varies per event. The deposit ensures that your musicians do not book other engagements that would conflict with your event. Although we are able to take last minute bookings, some clients book their ensembles for their weddings six to nine months in advance, we always recommend booking as soon as possible.
Thirty to Sixty days prior to your event, we will contact you via phone or email to discuss repertoire choices, special arrangements and any timing issues. Balance is due 7 days prior to the event along with a finalized itinerary and repertoire choices. Payments can be made by cash, check (made payable to your contact musician), or credit card. Credit card payments are processed via PayPal and are subject to a 2.9% + $0.30 fee (note: funded PayPal accounts are not subject to this fee). Please email or call for more information.
Sit back, relax and enjoy the music! Your ensemble will arrive with plenty of time to set up and begin playing at the agreed time in the contract. At some events it is possible for our musicians to stay longer than the agreed upon time if needed, this depends on our individual schedules. Payment for any overtime must be made on the day.


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Contractors and Locators Honored
for Commitment to Safe Digging
Miss Utility presents Maryland and Washington, D.C. excavators and utility locating technicians with 2006 Dig Smart
Awards and Locator Achievement Awards
HANOVER, Md. (April 10, 2007) Miss Utility is proud to announce the winners of its annual Dig Smart Awards and Locator
Achievement Awards. These awards honor the crucial people who have gone above and beyond to ensure the underground
infrastructure of Maryland and Washington, D.C., remains damage free.
The Miss Utility Maryland/D.C. Damage Prevention Committee established the programs to recognize excavating companies that
make strides to ensure workplace safety, and locators who have zero at-fault damages and exemplify outstanding safety
Dig Smart Awards
The 2006 Dig Smart winners are NPL Construction Co. and Iacoboni Site Specialists, both of Baltimore. These two outstanding
organizations were chosen from among hundreds of contractors across Maryland and the District of Columbia for these prestigious
awards, which are determined after a review of the companys damage prevention practices by other industry professionals.
NPL Construction Co., a first-time Dig Smart winner with 100 local employees, specializes in the installation, repair and
replacement of gas and underground electric for BGE, and has also served the D.C. metro area and suburban Maryland since
Iacoboni Site Specialists, a family-owned-and-operated underground utilities contractor for nearly 75 years, has 135
employees and belongs to multiple national and regional trade organizations focusing on damage prevention. Iacoboni Site
Specialists was the 2003 Maryland Dig Smart Awards Winner and won this years Dig Smart Award due to its excellent record in the
District of Columbia.
The Dig Smart winning companies were invited to attend the awards banquet with 25 of their employees, and both received the
Miss Utility Silver Shovel Award.
Locator Achievement Awards
Winners of the 2006 Locator Achievement Awards were determined from a group of locators, which were nominated by their
respective supervisor for being damage-free in 2006. Ballots were sent to the excavating community where one winner was selected
from seven different regions in Maryland. The regional winner with the most votes was honored as the 2006 Locator Achievement
Awards overall winner.
This years winners and their respective coverage areas are:
The grand prize for the Locator of the Year, Herman Wilson, was $500 in cash, a $100 gift certificate to Outback Steakhouse,
a Miss Utility-embroidered heavyweight work jacket, and a Miss Utility Silver Hard Hat award. The six other Locator
Achievement Awards regional winners received $100 in cash, framed certificates, and Miss Utility-embroidered golf pullover
jackets. Repeat nominees received a $25 Home Depot gift certificate and a framed certificate. Of the 2006 Locator Achievement
Award regional winners, both Heather Fowkes (2004) and Herman Wilson (2003, 2004, 2005) are repeat regional winners.
Awards Night
All of the awards were presented at a dinner banquet at The Sheraton Hotel in Columbia on March 29, with Tom Hoff, founder of
One Call Concepts, providing the keynote address. Mr. Hoff, who has four decades of experience in damage prevention, established
One Call Concepts in 1982.
One Call Concepts now serves 13 states, the District of Columbia and Alberta Province in Canada. Mr. Hoff lauded all
attendees for their roles as unsung heroes in keeping our technology-driven area safe from outages.
At this years awards, Kevin Woolbright of WSSC presented Governor Martin OMalleys proclamation of March 26-30, 2007 as
Underground Excavation Safety Week. In an effort to promote safe-digging practices, the proclamation reminds citizens to contact
Miss Utility before starting an outdoor project to prevent damages to underground facilities and property.
Throughout 2006, all of our winners both from Dig Smart and Locator Achievement have exemplified outstanding safe
digging practices and taken necessary measures to ensure their working environment is as safe as possible for colleagues and
residents of these communities, said Wayne Gilmer, Maryland/D.C. Damage Prevention Committee Chairman. We applaud these
companies and individuals who have emerged as leaders in safe digging and thank them for their sincere efforts to prevent
utility damage.
Solicitation for 2007 Dig Smart Award and Locator Achievement Award entries will begin this fall.
To view photos of the 2006 Locator Achievement Award winners, click here.


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ASCO's Quality Training Program prepares physician-led oncology teams to design, implement, and lead successful quality improvement activities in their practice settings. ASCO's program is developed by oncologists and oncology care specialists for oncology practice teams.
Specifically, the Quality Training Program
- Empowers practice teams to improve clinical care and operational performance
- Teaches teams how to balance quality improvement projects with demanding schedules and competing priorities
Course Structure
The 6-month program includes five days of in-person learning across three sessions, as well as hands-on learning at the participants' practices. To ensure a well-rounded experience, sessions include seminars, case examples, and small group exercises.
In 2018, sessions will be held regionally in Miami, FL, and Alexandria, VA. Participants who complete the course are eligible for MOC and CME credits. The locations will change each year with a plan to add international locations in the future. If you are interested in hosting a QTP in your country, please complete our International Interest Survey and contact us.
Two to four members of each team, including the team leader, must attend three sessions, with each session having two dates to choose from:
Miami, FL
- Application deadline was December 4, 2017
- Session 1: January 10-11
- Session 2: March 21-22
- Session 3: June 29
Alexandria, VA
- Application deadline is June 4, 2018
- Session 1: July 11-12
- Session 2: September 20-21
- Session 3: December 5
A structured and facilitated improvement project will be selected by each oncology team. Aside from meetings and coaching conference calls, teams will need to dedicate time and resources to complete their improvement project. By design, quality improvement requires an ongoing process. A structured and facilitated improvement project selected by each oncology team. This project enables teams to solve a problem in their own clinical setting, with guidance from experienced coaches.
Knowledge and Skills Acquired During the Course
Upon completing the course, participants will know how to
- Form a high-functioning improvement team
- Identify clinical and operational targets for improvement
- Plan and implement change strategies
- Understand and use data for improvement
- Track performance over time
- Use process analysis tools
- Flowcharting to understand processes
- Brainstorming to identify issues
- Creating a cause and effect diagram
- Creating a check sheet for data collection
- Identify priorities with a Pareto Chart
Conducting projects at the teams' practice sites delivers a great benefit, allowing the teams to immediately translate training into action to improve cancer care quality.
Continuing Education (CE)
Accreditation Statement and CE Credit Designation
In support of improving patient care, the American Society of Clinical Oncology is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
AMA Credit Designation Statement - Physicians
The American Society of Clinical Oncology designates this live activity for 14.25 AMA PRA Category 1 Credits ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
ANCC Credit Designation Statement - Nurses
The maximum number of hours awarded for this CE activity is 14.25 contact hours.
Participants will receive a brief survey before and after the Quality Training Program. This survey has two goals: To gauge progress toward learning outcomes as well as to provide feedback about the learning experience. Participants will be able to claim CE credits reflecting the extent of their participation in the Quality Training Program at the conclusion of the final learning session. CE certificates will be available for downloading and printing at that time.
Certificates of Participation and Attendance
Advanced practitioners are welcome to submit a request for a Certificate of Participation, which may enable nonphysicians to apply their Quality Training Program participation toward re-licensure. Please note, however, that all final decisions regarding the awarding of credits will be made by the licensing organization to which the credits are submitted.
Multidisciplinary experts in oncology and health care quality improvement lead the practice teams through the Quality Training Program. These experts bring many years of teaching and coaching experience to the program.
Quality Training Program Steering Group
- Michael Keng, MD
- Tim Gilligan, MD
- Doris Quinn, PhD
- Laurie Kaufman, MSN, RN
- John Bingham, MHA
- Vedner Guerrier, MBA, LSSBB
- Ashraf Mahmoud Mohamed, MD
- Anne C. Chiang, MD, PhD
Members of Steering Group may also serve as faculty and/or coaches.
Faculty and Improvement Coaches
- Charles Borden, MBA, Planned Parenthood of Northern, Central & Southern New Jersey
- Stephanie Buia Amport, MBA, CPHQ, Yale New Haven Health
- Vedner Guerrier, MBA, RTT, LSSBB, Memorial Cancer Institute
- Valorie Harvey, MBA, Parkland Health and Hospital Systems
- Joseph Jacobson, MD, Chief Quality Officer, Dana-Farber Cancer Institute
- Laurie Kaufman, MSN, RN, CPHQ, CMQ, MD Anderson Cancer Center
- Michael Keng, MD, University of Virginia Health System
- Louise Man, MD, University of Virginia Health System
- Eric Martin, MD, Medical Oncology Hematology Consultants
- Duncan Phillips, MBA, Senior Process Improvement Specialist at the Elliot Health Systems
- Steve Power, MBA, Duke University
- Arif Kamal, MD, Duke Cancer Institute
- Prabjyot Singh, RN, MSN, MPH, Trinity Health
- Piyush Srivastava, MD, Kaiser Permanente
- Holley Stallings, RN, MPH, CPH, CPHQ, Norton Cancer Institute
- Carole Tremonti, RN, MBA, OCN, CCRP, Senior Manager of Clinical Quality, Dana-Farber Cancer Institute
Explore the Quality Training Program
The Quality Training Program is funded through the Conquer Cancer Foundation.
2018 Supporters
This list reflects commitments as of May 9, 2018.


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Hosted by: MizB at Should Be Reading
Description: WWW Wednesday is a weekly event where you share:
(1) What you're currently reading,
(2) What you recently finished reading, and
(3) What you think you'll read next.
What are you currently reading?
HAHA!!!!! Not even between books, but there's loads upon loads I'll claim to be slogging through. I haven't had much luck these past few ARC's, so I'm avoiding everything basically. But I did read one paragraph of The Rest of the Robots by Isaac Asimov. So yay!!! Also, I read a chapter of my history book but I don't think anyone's interested in that.
What you recently finished reading?
Ann Aguirre's upcoming book, Mortal Danger. Finished yesterday. Reluctantly. The general readership is in favor, but I thought it was a drag. I can't believe how much time I wasted on it. If you have an ARC of the book, I suggest you drop it if the first 20% bores you, because trust me, it doesn't get better. Review will come, when I get a good book in these hands. Till then, enjoy the memes.
What you think you'll read next?
I think it could be The Kiss of Deception, The Jade Temptress, Half a King or Deep Blue. Or cake and lasagna recipes.
Goooooddddbyyyyyyyyyeeeeee, dear readers. I would do the whole xoxoxo routine but sadly, I'm not built like that.


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Valentino Rossi wrecked his bike and Alvaro Bautista avoided a broken back after a crash in an eventful opening day of MotoGP testing in Valencia.
Movistar Yamaha rider Rossi slipped out at turn 10 at Circuit Ricardo Tormo and his bike sustained significant damage after smashing into a tyre wall.
The seven-time premier class champion took a painful-looking tumble but was soon back to his feet and it was not long before he returned to the track.
The incident gave Rossi a chance to follow team-mate Maverick Vinales' lead and test out a new aerofairing on his Yamaha.
That bike is going nowhere! @ValeYellow46 is up and OK but his Yamaha is looking a little worse for wear after a crash at turn 10!#2018StartsNow pic.twitter.com/kbbCakypBS— MotoGP™ (@MotoGP) November 14, 2017
That's a write-off!— MotoGP™ (@MotoGP) November 14, 2017
The remains of @ValeYellow46's crashed Yamaha! #2018StartsNow pic.twitter.com/EwElwxxKCl
Pull&Bear Aspar rider Bautista's day ended early in the day after a big crash at turn one.
The Spaniard sat out the remainder of the test and was taken to hospital for examinations, which ruled out a fracture in his back.
That's not how you want to start testing— MotoGP™ (@MotoGP) November 14, 2017
Nasty highside for @19Bautista down at turn one, but luckily #RiderOK pic.twitter.com/EHtQgrPDHm
Álvaro @19Bautista has no fracture in his back, he only has a lot of pain in that area #2018StartsNow pic.twitter.com/pyi0vNKYrG— Aspar Team MOTOGP (@asparteam) November 14, 2017
Vinales set the fastest time, two tenths clear of Johann Zarco. Marc Marquez, who clinched the fourth title of his career on Sunday, edged Rossi as the day's third-quickest man.
24 de septiembre 2018
|Ryder Cup 2018: A sporting spectacular you cannot afford to miss
|Cricket Australia closes investigation into Moeen claim
|Zlatan impressed by ´MVP´ singer
|Modric hoping to complete FIFA and UEFA double at Best Awards
|Mickelson never doubted Woods would win again
|Woods looked like Tiger of old in 80th PGA Tour win
|Chelsea were too slow against West Ham - David Luiz
|Tottenham star Kane acknowledges sub-par start
|Rashid signs one-year all-format deal with Yorkshire
|Brady and Patriots crash to back-to-back defeats
|Gundogan looking forward to ´real test´ against Liverpool
|Cubs move closer to clinching NL Central
|Valverde bewildered by Lenglet red card as Barca boss questions VAR
|Cronk a ´long shot´ to play in NRL Grand Final
|Cleary re-signs with Panthers until 2024
|Bills stun Vikings, Chiefs QB Mahomes impresses again
|Tiger feels he can surpass Snead´s record after 80th victory
|Ronaldo mentally stronger than others, says Allegri
|MLS Review: Ibrahimovic scores as Galaxy end seven-game skid, Dallas reclaim top spot in west
|Rose told Woods it was ´about time´ after win
|Dustin Johnson regains number one ranking
|Pogba: Sanchez will deliver at Man United
|Federer, Zverev help Europe defend Laver Cup
|I couldn´t sit or stand – Tiger Woods reflects on back woes after ending drought
|Snead´s record in sight – Tiger Woods´ 80 PGA Tour wins
|Nicklaus, Magic Johnson, McIlroy and Kane – Sports stars celebrate Tiger´s Tour win
|Tiger Woods season in review: Tour Championship win caps remarkable comeback
|49ers fear QB Garoppolo suffered torn ACL
|World of golf is proud of Woods – Rose
|WATCH: Tiger followed by incredible sea of fans at East Lake
|Three takeaways from the 2017-18 PGA Tour season
|Mbappe shows off signed Pele shirt
|Tiger timeline: Woods´ fall and rise
|Spieth´s breakthrough, Garcia´s Masters moment - Events between Tiger´s triumphs
|Tiger Woods: I was close to tears on the last hole
|Woods earns first win since 2013; Rose claims FedEx Cup
|Pogba implores Manchester United to ´attack, attack, attack´
|Valverde, Busquets and Vidal criticise Lenglet dismissal
|Tiger Woods: The stunning statistics
|Fitness hindering Dybala form, says Allegri
23 de septiembre 2018
|BREAKING NEWS: Woods claims first title since 2013, Rose wins FedEx Cup
|Povetkin struggles leave Joshua with no Wilder fear
|Guardiola targets Barca, Bayern dominance with Premier League priority
|Centurions Rohit and Dhawan put India in final
|Eagles top Colts as Wentz makes his return
|Barcelona 2 Girona 2: Stuani brace punishes Lenglet red
|Frosinone 0 Juventus 2: Ronaldo redeemed as champions extend perfect start
|Gattuso: No alibis for two-faced AC Milan
|Bangladesh hold on despite late Afghanistan charge
|Composed Woods hits turn with five-shot lead
|Chiefs´ Mahomes has another record-breaking Sunday
|Saints QB Drew Brees passes Brett Favre for most career completions
|Emery hints Leno may need patience after Cech display
|Picamoles scores four as Montpellier batter 14-man Toulouse
|Messi breaks LaLiga record
|Worcester fend off prowling Tigers, Sarries go top
|AC Milan 2 Atalanta 2: Last-gasp Rigoni rescues a point
|Neymar keen to repay supporter affection
|Pellegrini rues West Ham´s wastefulness
|Paris Saint-Germain´s positive response buoys Tuchel
|Lewis rekindles fond memories with Vilamoura triumph
|Arsenal 2 Everton 0: Lacazette, Aubameyang extend winning streak
|Stephens suffers as Osaka withdraws in Wuhan
|Rhinos run riot to secure Super League status
|Risk brings reward for victorious Marquez
|Let´s have some fun - Wentz tweets message to Eagles fans ahead of return
|Maybe in a year Chelsea will be at Liverpool´s level – Sarri
|Under-pressure Rodgers bemoans ´bitty´ Celtic start
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Daenerys Targaryen Picture Drawn by my niece.
Drawing made by simple colorful ballpoint pens.
This awesome piece of art drawn with passion and fan love for this tremendous story. Great Christmas Game of Thrones fan gift.
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Spring break brought a lot of time to catch up on my reading this year. Best of all, one my reserves
Love and Math - Edward Frenkel came into the library before we left for the break. Overall, it was good read and led me to think more about abstract algebra than I usually do in my day job. The book interleaves Frenkel's autobiography with some of the math he was encountering along the way described in broad and fairly accessible strokes. I found this fascinating from several angles. There are the lengthy descriptions of growing up in 1980's russia pre-glasnost. One of the hardships he had to overcome was antisemitism that prevented Frenkel from attending the premier university for theoretical math and instead he ended up in an oil and gas applied math program, sneaking into the lectures with other fellow Jews.
On the flip side the description of his math education was quite positive. By 16 he was done with what we consider the normal elementary math sequence and had found a math mentor who introduced him to abstract algebra. Prior to that he was more interested in quantum physics (although I think the divide between the two is overstated) He then moved to college and was taken in wing by a very strong group of math professors and fellow students. Its hard to imagine a similar environment here in the U.S.
Also interspersed are longer discussions about topics such as loop theory and symmetries. These are done at the descriptive level and not suitable for really learning the subject. But its so rare to find any such material and it was great as a tour of what topics concern modern mathematical research. I found the descriptions of the Langland Program to be especially interesting. http://en.wikipedia.org/wiki/Langlands_program
In sum, I'd definitely recommend this to others. One of Frenkel's main goals is to give a clearer picture of what mathematicians really do and here he succeeds brilliantly. For future years I'm going to think about how I could connect material such as this to the fifth graders. So few kids at this point have any idea of the general terrain of mathematics and what a further career might concern. More immediately, they know they will study trigonometry and calculus eventually but at this point they couldn't really tell you what they concern in even very general terms. This is quite different from how we approach almost every other subject in the primary grades.


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NAIROBI, Kenya (AP) — A Kenyan judge on Wednesday ruled that a minor opposition candidate can run for president in this month's election, bringing fresh uncertainty a day after opposition leader Raila Odinga withdrew from the new vote ordered by the Supreme Court.
At the same time, lawmakers approved amendments to the electoral law that have been criticized by the opposition and Western diplomats. The amendments require the approval of President Uhuru Kenyatta, whose ruling party sought the changes after the Supreme Court nullified Kenyatta's election in August and cited "irregularities."
Elsewhere in Nairobi, police used tear gas to disperse thousands of opposition protesters who regrouped outside the election commission's offices and demanded reforms. In the opposition stronghold of Kisumu city, four people with gunshot wounds were admitted to hospitals after police used live ammunition to disperse protesters, a police official said. The official spoke on condition of anonymity because he was not authorized to speak with reporters.
Wednesday's court ruling appeared to open the way for other presidential candidates in the August election to run again on Oct. 26, though none aside from Kenyatta and Odinga received even 1 percent of the vote.
Justice John Mativo said he did not see any reason for Ekuru Aukot to be barred from participating in the repeat election. Aukot won about 27,000 votes of more than 15 million cast in the invalidated poll.
The Supreme Court last month rejected the August election in which Kenyatta was declared the winner after Odinga challenged the results, saying hackers infiltrated the electoral commission's computer system to manipulate the vote in Kenyatta's favor.
Odinga then surprised Kenyans on Tuesday by withdrawing from the fresh election, saying the electoral commission must be changed or the new vote risked having the same problems. His withdrawal created confusion in East Africa's largest economy, with observers wondering how the new election might go forward.
The election commission has said it was meeting with its legal team on the way forward. Kenyatta, who called the Supreme Court judges "crooks" after their ruling, has said he does not want changes to the election commission. His Jubilee Party has instead has used its parliamentary majority to push for the changes to the electoral law.
The opposition says the changes are meant to make the transmission of election results a manual process that would have fewer safeguards against fraud, and would make it more difficult for the court to annul an election.
Diplomats including the United States ambassador this month said the proposed amendments put at risk the election commission's "ability to conduct a better election" and unnecessarily increase political tensions.


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Quotations, extracts and words Shri Mataji talks, public addresses and advices; mostly verbatim. Shri Mataji is the founder of Sahaja Yoga technique, which grants self realization at the very outset.
Your outlook should be: how much have I contributed to this? Am I still thinking of other people? Am I still thinking of petty small problems, or am I thinking of my Spirit? Y3.V14.Mar83.p8
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Blog » Courtney
I finish up work early today and decide to meet up with a couple friends for a few happy hour beers. We talked a lot about digital marketing and I got called out a few times by Jennifer(Brad's wife) for checking out the waitress. I could not help myself. I love women and I have such a thing for nose rings. Obviously not the bull hook through the middle, but a diamond stud in the side gets me every single time.
We polished off about a six pack each before Brad and Jennifer decided to call it a night. Bill and I decided to stay a little longer because it was Karaoke night and things could get interesting if we stayed around and pounded a few more.
We ordered some fried chicken sliders, which by the way are absolutely delicious. Mowed them down and had a couple more beers. Bill was having some kind of drama with his pseudo girlfriend and he had to call it a night and go deal with that nonsense.
It was only like 9:30 so I figured I would stop by the bar down the street where my buddy John is a bartender. The commercial real estate market during the '07-'09 recession did a number on his business deals and he was forced to pick up some shifts at a couple local bars.
I rolled up there and was going to have a beer and head home. John and I talked it up like we normally do. I noticed a cute blonde girl with a pretty good rack was sitting a couple bar stools down from me. At first I thought she was there with the guy standing next to her. It turns out; he was just standing there ordering a drink for himself. She was alone, drinking draft beers and working on a Jagermeister shot. This is a reasonable sign that she may be willing to have a one night stand, so I decide to stick around for a little longer. I honestly do not remember what I first started talking to her about, so there is no great pick up line or tactic in this story.
We shared small talk, and I mentioned something about the wedding video floating around the internet that was reinvigorating Chris Brown's career. She had not seen the video clip so I pulled out my iPhone and looked for it. I was half ass listening at this point and was focusing on scrolling through countless Facebook status updates to find the correct post with the link.
Even when I am not consciously listening I can usually follow the gist of what someone is saying and passively participate in the conversation with staple comments like "sure", "really", "that's interesting" and "I did not know that". I finally gave up on Facebook and just did a Youtube search. I gave her my phone and let her watch. She then started talking about her wedding. Dammit. And she mentioned her five your old son. Double Dammit. Oh well, at least the kid was a sign that at least she likes to F&^%. She got real detailed in the description of the timeline of when she got married and how old the kid was, but not in a way like. Oh he's five and lives with his dad. She describes it in such a drawn out way, that I do not think I can give it justice by trying to explain.
"Seven years ago I got married and two years after that I had a son."
"Do you know how old he is now?"
"I am no mathematician, but seems like that would make him five."
"He is five. How did you guess?"
I hope this girl is joking and besides that, why the f*&% do I need a math test at the bar on a mother f*&^ing Wednesday. I am older than your five your old, basic math really is not a challenge for me.
We continued to converse. I asked her what she did for a living and she told me it was a long story. Long story to me usually triggers thoughts that she is a stripper or she is a hooker. Apparently neither, long story this time is that she works with blind kids. That's awesome news, she has a good heart, but why was that a long story.
Is your 7 minus 2 year old blind? Or, is it because when your kid was one, you figured out that four years later he would have another birthday on the same day? Well professor, you are correct, that kid is going to be five. I also got another math description when she described about three years ago when she got divorced when her son was two. At this point, I was almost wishing she was one of those women that refer to their kids in the number of months they are. That way, at least I would have some math to do in my head when we are pounding bodies later. It's a little trick to do in your head when you do not want to release too early. What is six hundred and seventy-six times four hundred and thirty-two? What is two hundred and ninety-eight divided by forty-nine?
My office is right by a blind school in Dallas, and I know the name of it already, I vaguely mention that there is a blind school by my office. She knew the name of it, so her story is coming together as truthful. It was just a weird feeling I got because I still did not understand why she figured the story about her current career was such a long one.
At this point, she still seems pretty normal. It's around 11 at this point and I am getting to the point where I want to either go home, pass the F out, or we can get out of here so I can feel what this chic's guts are like.
It's time to make a move. I look at her and I am about to suggest we go somewhere else. She beats me to the punch and poses the question to me about the man in the moon. What? I thought she was about to ask me if I wanted to go outside and check out the moon with her. Nope, she wants me to go outside, look at the moon and tell me if I can see the man up there. And she wants to know if I can find out his name.
"What? Seriously? I know what the moon looks like, besides what time of the month is it? Can you even see the moon? Is it a full moon right now? Is it a half moon? What are we really talking about here?"
"Go see if you can see him, he's up there."
"I am sure he is."
"Just go look"
"I have seen the moon, I know what it looks like"
"Who is it you turn to when you are alone at night? Who is always there for you when you need someone? Where can you find comfort? He is there. Look to him. He will guide you."
Ah, she is trying to be metaphorical and is actually referring to my penis. She starts scribbling on a piece of paper, wraps it up in a napkin and hands it to me.
"Do not open it right now. Save it for later, it has his name on it.
"Go see if you can see his name up in the sky."
I am pretty annoyed with this game and starting to think she may be a little off her rocker, but I have convinced myself that the piece of paper has some sort of directions to her vagina on it. So, I play along a little longer with the whole man in the moon theorizing. She goes on some more about how I need to go look for myself and see him.
"You really need to see him. You need to see his name up there. You need to feel him and see how he can guide you."
F#%k it. I pull the piece of paper out of my pocket and open it up. If I had any remembrance of what a normal girl was, the word written on the piece of paper may have surprised me. I have had my share of crazies throughout my escapades, so nothing really comes as a shock to me. I would have more enjoyed it if was something like "I want you under the moon tonight", "Your package is the man in the moon, and the address is my vagina", "her address". I would have been content with her number and we'll hook up another time when we are drunk again. Maybe I'll take you for a pitcher of beer and a tray of wings at Hooters. NOPE. "Gary" The fucking piece of paper said "Gary" on it.
What the fuck!!! Am I on TV? Is this some sort of joke television show I was not prepared to be on. Did I suddenly become famous and just got Punk'd? Where is Ashton?
"Gary, huh?"
"That's his name. You really should go outside and see him. He is out there and he wants to speak to you."
Unbelievable, I have somehow found another crazy chic. How do I find them? Some days my choices in women are terrible, but certifiably crazy is not my bag. This is a new one. John, who has been in and out of our conversations for a while now looks at me. I look back at him and my eyes are so wide open. This bitch is fucking chock full of nutz.
She had ordered a last beer and closed her tab. I had decided to do the same, since this is pretty much the end of this evening. I am not hooking up with crazy pants over there. I am going to go home and jack off. I order another beer and close my tab.
Cuckoo Butterworth next to me ends up leaving at the same time as I am. I imagine she was waiting, because she wanted me to walk her outside so I can check out her moon cult up in the sky. We walk by her car and she insists on walking with me to mine. We awkwardly exchange pleasantries and she starts to caress me a little.
What am I doing here? Get in the car and leave. She is crazy and you do not need this kind of drama in your life again. The beer, bad judgment and my own personal man in the moon, my penis, aka Tony Danza, is the boss of me once again. I move in for the kiss. I get denied. W.T.F.
"You need to find the moon first."
"You're serious?.?.?… You are crazy."
She sports a pissy face at the crazy comment but continues kissing on my neck, so I humor her.
"Oh look, the building is blocking the moon, so I guess we cannot play this game anymore."
"Are you going to call me and take me on a date?"
Kissing on the neck
Lying: "Sure, I'll call you."
I had already given her my business card earlier in the evening. She had a half decent idea for some online business she wanted advice about. Whoops. Oh well, she probably will not call, I did just call her crazy to her face when she would not kiss me. She walks away over to her expensive Lexus. Helps blind kids? I am pretty sure helping blind kids does not pay quite that well.
"Are you going to call me and take me out?"
"Sure, I'll get your number from Gary."
Smiles like I made her night, gets in the car and drives away.
The Girls That End in "E"
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Some folks here might know who Randy Bachman is.. He's a pretty well known name in Canada.. Anyway he is hosting a radio show on Saturday nights on CBC. Tonight his is talking about guitar tunings and has played some Lenny Breau and just featured some early Elvis with Scotty Moore .. Anyway you can listen in on the internet...
http://www.cbc.ca/programguide/program/ ... vinyl_tap/
You just need to click on the Listen tab and follow the links.. I needed a plugin for my browser, but after that it worked.
Live radio show hosted by Randy Bachman
Discussion of history's greatest guitar player.
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Live radio show hosted by Randy Bachman
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|The Union Bank of Switzerland (UBS) merged with Swiss Bank Corporation in 1998 to become UBS AG. This intensive greenroof system shows ingenuity on the part of the owner and the architect, Burckhardt Architects. The offices below this area were originally covered by a concrete slab roof, which was opened up by incorporating moveable slabs. Greenroofs were then installed over the entire area. The retractable slabs were developed as planters to blend into the design of the surrounding greenroof. By retracting the slabs during the day, daylight is allowed into the offices below.
|The ZinCo Floradrain FD 60 build-up system was used.
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