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This article originally appeared in the December 2010 issue of Architectural Digest.
Every now and then you come across a new house that has an old soul. It is not always easy to figure out how this happens to be. Sometimes old or salvaged materials, repurposed in new construction, bring with them a sense of history. Sometimes a house is built on an earlier foundation and retains the spirit of its ghost ancestor. Sometimes, though, the design of a house is rooted in longtime relationships exposed to new ideas through hours of conversation and debate about how the place should look and live, which rules it should follow and which it should break—how, in short, it might best express the combined thinking of its owners, architect and designer.
Such is the story of the house that the architect Jason Chai and the designer Stephen Sills recently completed for a Connecticut family. The project grew out of a web of old connections. Sills had designed an earlier home for the couple and had spent 15 years helping them assemble an array of furniture and antiques; Chai is the wife's cousin and had designed modest additions to the family's previous residence. Yet nothing in the planning process was taken for granted. The husband, who is in business, had strong ideas about how the house should sit on the site, a special piece of land that spills down to the Connecticut shore. The wife, an avid reader who describes the poet Elizabeth Bishop as her own personal sun, prepared for design meetings by reading Bachelard's Poetics of Space, and she challenged and probed her cousin's ideas at every turn.
Over time a concept began to take shape. Although the house was to be large, the wife had a fear of "McMansion unruliness." So when Chai introduced her to the vernacular of the Dutch dairy barn, she was intrigued: The volumes were pleasing, yet the gambrel roof could hide an impressive amount of space. "She was also concerned about the house seeming too fancy," Chai recalls. "So we undercut the obvious size and the emphatic metal-shingle roof by using a lot of timber details that are Scandinavian in flavor. They helped make the house feel more down to earth."
The clients very much wanted the interior organization and ambience to reflect who they were and how they actually lived. This is a family where the children (two daughters, 15 and 12) study ancient Greek and know enough Latin to translate Catullus. "We all live in books," says the wife, who quite understandably asked that the house have not just one large library but many smaller rooms to house the proliferating volumes.
She had other specific requests too. They never dine formally, so they didn't need a dedicated dining room. She wanted to be able to reach her children's rooms without having to exit onto a hallway, so the master bedroom opens to a sitting room, which opens to the daughters' bath and bedrooms. Eccentric but intimate, to be sure. She wanted spaces that did not have a specific purpose, rooms to "think in, to read in, to be in." "The interior flow is intentionally idiosyncratic," says Chai. "Instead of hallways, you have smaller rooms that lead to larger ones. I quoted Artur Schnabel to my cousin. He said that he handled the notes no better than any other pianist, but the pauses between notes—that was where the art resides."
The pauses between notes: something similar happens in Stephen Sills's work here. "Jason created a magnificent house, with beautiful proportions and details that make reference to Swedish, Dutch, Islamic and Moorish architecture," Sills says. "The house is so strong a presence that my client did not want to live with superficial decoration. This is why I left so many of the rooms white and paid so much attention to negative space."
Take a look at the wall above the living room fireplace: Where a more conventional designer would hang a mirror or a painting at this focal point, he chose to allow the wall to breathe, then flanked it with a grid of Chinese drawings. He left the wall above the sofa empty too, focusing attention instead on the shape and proportion of the room and the silhouettes of pale French furniture and Asian antiques collected over the years. "The whole room," he says, "is about a positive-negative interaction that paradoxically creates a sense of tension and a sense of serenity at the same time."
The library shows Sills working in a different spirit. "Before Stephen touched this room, it was cold and cavernous,"says the client, who hoped for something very different for her library. Sills took one look at the space and intuited that a subtle use of pattern on pattern would create a subtle cocoon for the family's vast quantity of books.
How fitting that the children's favorite seating is the flotilla of French mushroom stools, since this is a house where books mushroom and so do ideas: Geometric shapes, which served as models for 19th-century artists, become decorative objects; a slightly menacing wooden pineapple hangs over the breakfast room table in place of a chandelier; a vast foyer is naked except for a few punctuation marks of furniture. "I deliberately try to make my interiors less pretty," says Sills. "I like things that are off, that are not consciously decorated. It gives a house much more energy, much more humanity. That way, it's less like design and more like actual life."


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Your newborn is only a 'newborn' for just a few short weeks. Make sure you have stunning memories of those tiny hands & feet!
This is also a great time to update your family portrait to include the newest addition to your family for Christmas or birthday gifts.
Visit the Prices & Contact page to make an easy online enquiry or check out our pricing.
All images © Copyright protected Horsfall Photography Tel: 086 728 8885
Portrait & Wedding Photographer Killaloe, County Clare, Ireland
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subset: commoncrawl


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Purple Kale Sprouts Christmas Salad
Have you heard of or tried this new healthy and trendy vegetable - Purple Kale Sprout?
Basically, purple kale sprout is "a hybrid cross of Russian Red Kale and Brussels Sprouts. Also known as lollipop sprouts or lollipop kale. Kale Sprouts have a sweet peppery flavor and crispy fresh texture. Use as a tasty garnish for meat entrees, mixed with spring greens in a salad, or simply sauté lightly with mushrooms and garlic." (cited from www.melissas.com)
For the upcoming Christmas dinner, I prepared the recipe for this kale sprout salad, which could serve as a great side dish to compliment the any meat, fish or vegetarian main dishes. It is my first time to cook with new interesting vegetable. Once you have tried it, I would love to hear what you think! Merry Christmas, everyone!
Serve 2
What you'll need:
400 g purple kale sprouts
1 oranges
2/3 cup of fresh cranberries or 1/3 cup dried cranberries
1/3 cup of pecan
1 tbsp tahini
1/2 tbsb honey
1/3 tbsp dijon
1 tbsp orange or lemon juice
2 tbsp extra virgin olive oil
Pinch of sea salt
How it's made:
1. Wash the purple kale sprouts and cut them in half. Bring a large pot of water to a boil, then add the kale sprouts and boil them for no more than 3 minutes, pour into a colander and rinse immediately in cold water. Then pour the dressing over the sprouts, toss well to coat.
2. Toast the pecans in a dry frying pan on medium heat until slightly browned and crispy, but be careful not to burn them.
3. If use fresh cranberries, then in a small saucepan, combine the cranberries, maple syrup, and orange zest. Cook over moderately low heat, stirring, until the cranberries break down and thicken, about 10 minutes. If use dried cranberries, no need to cook it. Just add them to the salad at the next step.
4. Put pecan, oranges and cranberries in the bowl and toss with hands to mix. Serve right away or let sit for an hour. It tastes nice both ways.


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This lamb vindaloo is mouthwatering, spicy and hot curry. Those who doesn't want it to be hot you may skip adding chilly to it. Its a perfect dish for those who crave for a hot lamb curry.
The addition of potato into this dish further enriches the curry.
So here is the yummy mouth watering Lamb Vindaloo. This recipe
Serves- 2
Preparation time- 20 minutes
cooking time- 40 minutes to an hour
Level of difficulty- Medium
- Lamb - 450 g
- Oil- 1 Tbsp
- Cumin seeds- 1 Tsp
- Onion- 1, sliced
- Green chillies as per taste
- Water- 300 ml or substitute 100 ml of water with some wine
- Potato- 1, quaterd
For the marinade-
- Lime juice or vinegar- 2 Tbsp
- Crushed pepper powder- 1 Tsp
- Red chilli powder- 1 Tsp
- Olive oil- 1 Tbsp
- Ginger garlic paste- 1 Tbsp
- Salt as per Taste
- Garam masala powder- 2 Tsp
- Cinnamon stick- 1
- Cardamom pods- 4
- Cloves- 4
- Bay leaf- 1
- Turmeric powder- 1 Tsp
- Coriander powder- 1 Tbsp
- Cumin powder- 1 Tsp
- Pepper powder- 1 Tsp
- Chilly powder- 1 Tsp
- Water to prepare paste
- Heat Oil in a pan. Add the cumin seed and allow it to crackle. Once it starts crackling add the green chillies and onion. saute until onion turns translucent.
- Add the marinated Chicken. Fry for 5 minutes.
- Prepare a paste of other spices as mentioned and then add this paste to the Lamb.
- Add the potatoes
- Fry for 15 minutes.
- Crush the whole spices getnly in a mortar with the help of pestle .Now add the whole spices to the pan. stir once.
- Add the water and let this simmer in medium to low heat for about 30 to 40 minutes, until the lamb gets tender.
- Garnish with green coriander.


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Having egg on your face is not typically associated with good things, but in this case, it's actually a great thing! Using the incredible, edible egg as a cosmetic is actually totally doable. How? Well, if you've ever used a peel-off pore strip, the kind that rips gunk right out of your pores, you know how perversely satisfying they are. But did you know egg white can serve the same function?
All this skincare trick requires is an egg and a piece of tissue.
See how to make your own awesome peel-off mask here:video-player-present
Painting raw egg on your face might sound dicey, but eggs are actually full of nutrients that can do wonders for your skin.


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The paper presents an agent-based model to study the possible effects of different fiscal and monetary policies in the context of debt deflation. We introduce a modified Taylor rule that includes the financial position of firms as a target. Monte Carlo simulations provide a representation of the complex feedback effects generated by the interaction among the different transmission channels of monetary policy. The model also reproduces the evidence of low inflation during stock market booms and shows how it can lead to overinvestment and destabilize the system. The paper also investigates the possible reasons behind this stylized fact by testing different behavioral rules for the central bank. We find that, in a context of sticky prices and volatile expectations, endogenous credit creation can be identified as the main source of the divergent dynamics of prices in the real and financial sectors.
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Hi Folks! So the month of March brings lots of great specials to the Creperie! Its officially Girl Scout Crepe Season! This year we've got our Triple Chocolate Thin Mint Cheesecake, our Nutella Ice Cream Crepe with Tagalong Cookies and Toasted Coconut, and new this year is our Lemon Crème Crepe made with yummy mascarpone cheese, fresh blueberries, Savannah Smile Cookie crumbs and topped with a warm blueberry reduction and toasted almonds! YUM! AND, we've also got our version of the Shamrock Shake...only better! We make ours with fresh mint, Nutella, frozen yogurt, and Thin Mint Cookie crumbs!
Also in March; we're helping to raise money for the Relay for Life by offering a signature beverage! Its a Peanut Butter Nutella Mocha and for every one of these drinks we sell; we'll donate a dollar to the Relay for LIfe! Support this great cause with a yummy beverage!
Join us Tuesday March 4th as we not only debut our Girl Scout cookie crepes; but we'll also be honoring all the girls that come in to eat wearing their vests or sashes with a hearty discount!
So join us this month and try some of these delicious specials! See ya'll soon!


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POSADA DON CARLOS colonial hostel
POSADA DON CARLOS colonial hostel
The space
Location is everything when choosing accommodation in Ciudad Bolivar!
Posada Don Carlos guesthouse is a colonial mansion, built in 1876, carefully restored by its owners. Located in the heart of the historic quarter in Ciudad Bolivar, it is only steps away from Bolivar square and 200 meters from the Orinoco River. Combining traditional atmosphere with modern conveniences, the options range from sleeping in a hammock to staying in very elegant rooms. Priced as a hostel, we offer hotel-quality service.
We have four elegant rooms with air-conditioning and six comfortable rooms with a fan. They all have en-suite bathrooms. Our terrace is equipped with six hammocks, three bunk-beds and two bathrooms.
Two ample patios with corridors and an antique-style bar, await you for chilling out. We will gladly prepare delicious creole, international and vegetarian dishes.
Free wi-fi, luggage store-room, Garage, laundry-service, safe
We also offer tours to:
Rio Caura / Amazon Rainforest
Orinoco Delta
Roraima Trekking
Gran Sabana
Los Llanos
Los Roques
Please note:
Breakfast not included


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Glory Hole Longmeadow
Create a free membership and you can be discovering the lifestyle of a private male on male sexual encounter at a Longmeadow gay spa, no names, fully discreet.
Search for a glory hole, gay sauna or gay bath house from Gay Sauna Massachusetts including Longmeadow and nearby cities,
Agawam (2 miles), Sherwood Manor (2 miles), Springfield (3 miles), Thompsonville (3 miles), East Longmeadow (3 miles), West Springfield (4 miles), Hazardville (5 miles), Enfield (5 miles), Southwood Acres (6 miles), Suffield Depot (5 miles), Chicopee (6 miles), Somers (8 miles), Wilbraham (9 miles), Windsor Locks (9 miles), Hampden (8 miles), Southwick (9 miles), Ludlow (9 miles), Broad Brook (9 miles), Westfield (9 miles), Holyoke (10 miles), Ellington (11 miles), Salmon Brook (12 miles), Tariffville (13 miles), Crystal Lake (13 miles), North Granby (13 miles), Monson Center (14 miles), Monson (14 miles), South Windsor (13 miles), Windsor (13 miles), Three Rivers (14 miles), South Hadley (14 miles), Stafford (14 miles), Southampton (14 miles), Granville (14 miles), Rockville (14 miles).
Register for free to contact any of the gay cruising profiles in Longmeadow or browse Gay Sauna Massachusetts for more cities.
780 Longmeadow St
United States
Gay Sauna Massachusetts
Glory Hole Agawam | Glory Hole Springfield | Glory Hole East Longmeadow | Glory Hole West Springfield | Glory Hole Enfield | Glory Hole Chicopee | Glory Hole Ludlow | Glory Hole Westfield | Glory Hole Holyoke | Glory Hole Ellington | Glory Hole South Windsor | Glory Hole Windsor | Glory Hole South Hadley
There are approximately 71 registered profiles from Longmeadow. Including surrounding areas of Agawam, Sherwood Manor, Springfield, Thompsonville, East Longmeadow, West Springfield, Hazardville, Enfield, Southwood Acres, Suffield Depot, Chicopee, Somers, Wilbraham, Windsor Locks, Hampden, Southwick, Ludlow, Broad Brook, Westfield, Holyoke, Ellington, Salmon Brook, Tariffville, Crystal Lake, North Granby, Monson Center, Monson, South Windsor, Windsor, Three Rivers, South Hadley, Stafford, Southampton, Granville, Rockville, there are over 1,918 members and growing every day.


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The reebok classic pump trainers were the first of their kind to merge an internal mechanism into a sports shoe, improving the overall fit of the shoe, while still maintaining a classic style. Read more about Reebok Pumps.
Reebok Pumps were the first shoe to have an internal inflation mechanism that meant you could make them fit more snug around your foot.


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Words containing alazhdar
Found 1 words containing alazhdar. Browse our Scrabble Word Finder, Words With Friends cheat dictionary, and WordHub word solver to find words that contain alazhdar. Or use our Unscramble word solver to find your best possible play!
- Scrabble
- Words With Friends
- WordHub
- Crossword


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Wednesday, August 27, 2008
Coming Soon!!!
Detail from Constitutional Doublecross 2008 Emily Duffy Photo by Sibila Savage
Welcome to the site of my upcoming exhibit of mixed-media sculptures. I'll be showing the sculptures themselves at True World Gallery next month, starting October 11, 2008. True World Gallery will be exhibiting this work in collaboration with neighboring Red Arrow Gallery under the title "11th Hour". The dual-gallery exhibit will be located just a few miles from one of the nation's largest Marine bases, Twentynine Palms.
I'm hoping my art will change some minds, and some votes, away from the Republican pro-war policies of John McCain, and toward Barack Obama's withdrawal plans for our troops in Iraq. Our nation simply can't stand another GOP administration!
My exhibit is also part of a national effort by artists who create political work. Art of Democracy is a network of exhibitions and events taking place in New York, San Francisco, Chicago, Seattle, St. Louis, Puerto Rico, and more locations.
Along with a vast myriad of political organizations, artists all across this great country are pitching in to help save America from continued ruin by radical right-wing politicians.
Please visit my regular BLOG for news and action items. I post there almost daily.
Posted by Emily Duffy at 7:39 AM
2 comments:
- C. L. DeMedeiros said...
Dear Emily,
How big will be the elephant?
I hope is the one which take 8 years to kill...by a black hunter riding a dunkey.
Anyway, thanks for your feed back
I so like your blog
yesterday I was thinking when you gonna drop by to tell me something.
It's been hard, but I enjoy doing art it's my greatest pleasure.
I found a hebrew book in a dumpter and the watch wrist was give by a fellow friend from my art school.
People are giving me crazy stuff all the time.
they think I always can do something with it.
Don't be shy
stop by always.
I have a body of work using broken toys: "Toys with issues"
I cannot wait to display them here.
stay tune
- September 1, 2008 at 11:48 AM
- Emily Duffy said...
C.l. the elephant you see on this page is a detail of one of the sculptures I'll be exhibiting here soon.
- September 3, 2008 at 2:28 PM
Subscribe to: Post Comments (Atom)


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A Fan's Guide to 2016
posted in: Blog Post | 0
If Pretty Lights was a storybook (and it is), 2016 was the most exciting chapter so far. Ask any diehard fan, and they will tell you that Pretty Lights is more than just music. When experienced LIVE , it is … Continued


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Yes, you do need lessons!
But, why would you believe me? After all, it's in my commercial interest for you to have lessons. If you don't think you need lessons have a look at kitemares.com, look at the links section of this web site or ask any kiter at any beach where you think you might go kiting. If you decide you don't need lessons, then please don't kill yourself, any of my kiting friends or an innocent bystander at any of my favourite kite spots.... such action is likely to get the sport banned!
Lesson Structure
Moreton Bay Kiting lessons follow the Kiteboarding Australia curriculum. Within this, each lesson program is tailored to each individual student through discussions before any lessons. If you are not a novice, your competence in appropriate parts of the curriculum will first be assessed and we will cover only areas in which you are not competent. For students prepared to do some reading and review of online videos, the theory component of lessons can be reduced and lessons can be devoted more to acquisition of practical skills. Moreover, some pre lesson study will facilitate acquisition of practical skills.
See below examples of the lesson structures that can be followed within this curriculum and don't forget about practice!
Lesson Options
1. Just Teach Me
10-20 hours teaching: $800 - $1,600
In this program the student does no study or practice outside of lessons. Accordingly, lessons cover all theory and every aspect of each practical component is fully explained and implemented.
A student taking this program should expect to require between 8 and 16 hours of one on one tuition.
This program is for those who don't want to do any self directed learning and whose budget is not as constrained as mine....
2. Some self study/practice with a fair bit of help
6 hours teaching: ~$600
Commence by getting a trainer kite and manual. Have a short free lesson on setting up and flying the trainer kite.
Fly the trainer kite for several hours over a few days and watch the nominated online videos. You will have documetation covering what you should achieve with the trainer kite and how to do that.
When you are very proficient with a trainer kite, it is time to have a lesson with a power kite. In the first 2 hour lesson you will rig and fly a small power kite and learn safety systems and procedures and body dragging skills.
The second 2 hour lesson reinforces safety issues, covers further body dragging (including upwind) then introduces a board. Students adopting this learning strategy should get gear after the 2nd lesson so that they can practise before the 3rd lesson.
In lesson 3 all emphasis will be on riding. Flying the kite will be automatic. Be able to ride upwind by the end of the lesson.
3. Active self learning
4 hours teaching: ~$400
Similar to approach (2) but with 2 x 2 hour lessons rather than 3 x 2 hour lessons. The student would acquire a power kite (and harness, PFD, helmet, booties etc) after the first lesson and practice with that before the second lesson. She/he would also require more independent practice after the second lesson before being able to go upwind.


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Organization: Development Alternatives, Inc.
Closing date: 30 Dec 2016
Agricultural Development Young Professionals Internship Program (ECOWAS)
Call for Applications :
Entry to Mid -Level Grants & Contracts Management Associate
Opening Date: December 19, 2016
Closing Date: December 30, 2016
Africa Lead II—the Feed the Future: Building Capacity for African Agricultural Transformation Program—supports the advancement of agricultural transformation in Africa as proposed by the African Union Comprehensive Africa Agriculture Development Program (CAADP). Simultaneously, Africa Lead II contributes to the Feed the Future (FTF) goals of reduced hunger and poverty by building the capacity of Champions—defined as men and women leaders in agriculture—to develop, lead, and manage the policies, structures and processes needed for the transformation process.
The scope of Africa Lead II is divided into three components, as follows:
Component One: Establishing and Improving Effectiveness of Institutional and Organizational Architecture for African-Led Agricultural Transformation.
Component Two: Strengthening Capacity to Manage and Implement the Policy Change and Alignment Process.
Component Three: Promoting the Effective Participation of Non-State Actors (NSAs) in the Policy Process and Providing Capacity Strengthening Support when Necessary.
Africa Lead II's Agriculture Internship Program aims to facilitate more efficient agricultural production, stronger agribusinesses and agricultural development institutions, a more direct link between NARS and farmers, and greater value addition in the agriculture sector across Africa. The broad goal is to support skills transfer and technological know-how that will help African agribusinesses and organizations to innovate, improve their commercial viability and catalyze agricultural transformation, thus contributing to improved food security.
The Africa Lead II Program welcomes applications from candidates interested in pursuing young professionals development opportunities. Placement terms will be for a period of 12 months with anticipated postings in ECOWAS member states: Benin, Burkina Faso, Côte d'Ivoire, the Gambia, Ghana, Guinea, Guinea-Bissau, Liberia, Mali, Niger, Nigeria, Senegal, Sierra Leone, Togo and Cape Verde.
Housing, monthly stipend, living allowances, round-trip airfare and related travel expenses to worksite will be covered by the program. The 12-month young professionals development opportunities are not guarantees for full time employment upon successful completion of the placement.
Entry to Mid-Level Grants & Contracts Management Associate
- Coordinate grant award cycle which includes but is not limited to providing guidance and training internal staff as they coordinate the subaward/subcontract life-cycle such as scope of work and budget development; monitoring and evaluation according to the compliance monitoring plan; reporting requirements: procurement integrity as appropriate; and close-out procedures.
- Review award terms and conditions; edit documents for completeness, accuracy and compliance with donor requirements prior to submission for donor approval and/or execution.
- Review and prepare portfolio-based communications to inform executives of identified contractual issues.
- Review and edit regular reports to assess the quality of subaward and service contract processes and to inform development strategies and business planning.
- Assist in the development and review of systems organization (e.g. templates, standard operating procedures, approval processes, databases). Create, update and maintain grants and contracts management tools and resources.
- Assist in the development or management of the Awards Management database as well as other electronic and hard files.
- Support supervisor with special initiatives and projects as assigned.
Required skills:**
· A minimum of Bachelor's degree in social science, human resource, administration, or related field. Master's degree preferred
· Ability to handle multiple tasks and demands, establish priorities and work effectively in a deadline driven environment; accuracy and attention to detail in the performance of duties is of critical importance;
· Strong verbal and written communications skills; with ability to interact professionally with culturally and linguistically diverse staff and external stakeholders;
· Ability to participate as a team member and work independently, with limited supervision;
· Willingness to learn and apply new skills and knowledge
· Ability to take on a leadership role as assigned by supervisor.
· Strong analytical skills and attention to detail are required;
· Computer literate with use of Internet, Word, Excel and PowerPoint
· English Native –French written and oral strong proficiency – Bilingual in English/French preferred. Note: candidates selected for an interview will required to demonstrate language proficiency and may be asked to submit writing samples of past work, and a writing and oral assessment may also be administered
Minimum qualifications:
- Strong organizational skills and attention to detail
- BS/BA degree required, advance degree preferred (with 1-2 years relevant administrative or technical professional experience)
- Excellent oral and written communication skills
- Must be able to travel and be based within regional institution in West Africa during the entire duration of the placement (minimum 1 year assignment)
- Fluency in both French and English required
Preferred qualifications:
- Experience in West African regional agricultural development
- Field related experience in urban and rural African settings
Application requirements:
All candidates must submit the following required documents:
· Curriculum Vitae
· 1-page cover letter highlighting ability to contribute your skills towards enhancing capacity of a regional organization involved in food security. Kindly specify your strengths and weaknesses and ability to adapt to new multi-cultural environment.
· 3 references; 2 professional and 1 personal.
Nationals of ECOWAS countries welcome to apply. Please send applications to: firstname.lastname@example.com by December 30, 2016 at 5:00PM GMT.
How to apply:
Application requirements:
All candidates must submit the following required documents:
· Curriculum Vitae
· 1-page cover letter highlighting ability to contribute your skills towards enhancing capacity of a regional organization involved in food security. Kindly specify your strengths and weaknesses and ability to adapt to new multi-cultural environment.
· 3 references; 2 professional and 1 personal.
Nationals of ECOWAS countries welcome to apply. Please send applications to: email@example.com by December 30, 2016 at 5:00PM GMT.
Read more here:: ReliefWeb


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In a day which the date was November 4th, 1999, a talented guy said "Hello World!". This guy was always interested in staring at some scenes that others don't even look at. This mentality navigated him to learn photographic principles and technics. Bought his lovely Nikon Camera and said to his new world, "Hello World!"! Amin has won some awards about city photography in Mashhad. Worked and hanged out with many photography groups and learnt how to adopt different conditions. He is now ready, under the name of Persia Studio, to capture photos of brands, guys and cats!
scene hunter!


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Simple Ways to Improve your Usability Research
Usability testing and user testing in general can provide valuable insights into your designs. Recently I've been working on some usability testing on some designs for a SaaS product. Here are some useful tricks I found to be helpful.
Plan Ahead
Planning any sort of user testing session requires time, however it is well worth doing as you'll yield the most reliable results, and in most cases "winging it" just won't do.
Planning begins by preparing the test mock ups or site; from this you need to create a test script and schedule for yourself. The easiest way to create a plan is to list what the aim of the user testing session is; this way you can focus your questions and tasks.
After this is done take some time to sanity check your plan and user test with someone who you won't be testing on. This way you can amend the test as you see fit.
This planning part of the user test is really for yourself. The test participants are more likely then not to behave in ways you haven't anticipated; this isn't something to be disheartened by.
Think of the Logistics
When testing without a dedicated testing room, it is worth trying to conduct the user testing sessions in the same room, this way it will reduce the amount of time spent setting up.
Try to create the closest possible experience to the 'real thing' you can. You can do this a few ways:
- Use a mouse (not a Magic Mouse unless the user actually uses them).
- Chose a non-natural scrolling setting as this is typical a PC setting.
- Create a task as close to real life situation as possible. If necessary add a time limit.
Recruiting your Testers
There are many ways for recruiting users for usability testing. You'll need someone with at least basic knowledge of the service you are designing for.
In my experience I found this to be a little difficult when dealing niche or complex software services. The easiest way to find people is to test internally; a bonus to this is that you don't need to deal with any compliance or security issues.
When it comes to how many users you should test on I found that the Nielsen Norman Group's recommendation of 5 has worked best. By only testing on five users per test you'll spot the biggest usability issues in your design and allow for a quicker interactive design process.
- Create a script for yourself, this will create consistency throughout your tests.
- Sanity test your plan and testing session with someone you won't be testing on.
- Try and test in the same room — It'll be easier for you.
- Test the equipment before hand — You don't want tech failing you when you should be testing.
- Mimic the conditions and scenarios the user might face.
- If it is difficult getting external testers, use your companies employees.
- You only need to test on 5 people per test.
About the Author
Marwa Khalil is a London based UX and UI designer who has had the chance to work with some great London startup including Nutmeg and Peak. She is a regular contributor and editor for the LTUX London blog. Stay up to date with her on Medium and Twitter.
Originally published at ladiesthatux.com on August 6, 2016.


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Bought shoes for my wedding and I was unhappy with the material. So I contacted JJ's support and they refused the return.
I ended up wearing them on my wedding day since I had no money for any others. They broke directly after the ceremony as we were riding down to the main floor of the courthouse.
Fortunately I had some flip flops in the car to get through the reception. Ridiculously priced for the material at $48 and couldn't even make it though an hour of walking!
Reviewer is in unhappy mood. Please immediately contact the author of this review to discuss bad quality of jjshouse shoes. Jjshouse needs to read this review and look into the issue (if any) according to poster's claims.
Other people also mentioned jjshouse shoes in their reviews. You may find this information helpful for further shopping at Jjshouse.


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Dierks Bentley Hangs With the Stanley Cup
Dierks Bentley was joined on stage on Saturday, June 20th at the Windy City LakeShake in Chicago by NHL Stanley Cup winners the Blackhawks. The Chicago Tribune reports that team members Duncan Keith, Jonathan Toews, Patrick Kane and Patrick Sharp joined Dierks during "Drunk On A Plane." They gave the singer a No. 7 Blackhawks jersey, which he said was his lucky number, with his last name on the back of it.
Dierks told the crowd, "If you're going to get drunk on a plane, you need a really big cup." The players then walked on stage carrying their big Stanley cup, which they handed to Dierks and let him parade around the stage.
.@LakeShakeFest. honestly one of the best nights of my life.#chicago. #StanleyCup #NHL #heavierthanithoughtitwouldbe pic.twitter.com/gBB1PJvbzq
— Dierks Bentley (@DierksBentley) June 20, 2015


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The Pacific Coast begins at Cape Howe, which marks the eastern extremity of the state border of Victoria and New South Wales, and extends to the northern tip of Australia - Cape York in far North Queensland. It was along this coast that Lieut. James Cook travelled on his epic voyage of exploration in 1770, mapping as he went and documenting for the first time the country that became known as Australia. This drive mirrors his journey, through Cook saw it all from a different perspective - he traversed the coast by sea.
These days it is possible to follow the east coast of Australia most of the way on sealed bitumen roads, starting at the old whaling town of Eden on the NSW south coast, and ending at Cooktown in north Queensland. This drive utilises these ribbons of bitumen, but begins in Melbourne to allow the whole drive from Melbourne to Sydney via the Princes Highway to be included.
Two alternative inland return routes are suggested, however if money and/or time is an issue, you may consider hiring a motor vehicle and driving one way, leaving the vehicle at Cairns if travelling north, or at Sydney or Melbourne if travelling south, before flying home or on to your next destination.
Of all the long distance drives I have done in Australia, this would have to be one of the most memorable. It passes through or close to some of the best coastal and inland scenery in the three states on Australia's eastern seaboard (Vic, NSW and Qld), it includes Australia's three largest cities, as well as Australia's most visited holiday and tourist destinations (except for Uluru). It also affords the opportunity for Australians to 'taste and see' holiday destinations outside of their home state with a view to finding specific places to return to at a later date for a closer look.
In a nutshell, this drive showcases much of what people come to or travel Australia to see, all in one simple drive that can easily be handled by the average family car with 2 or more people sharing the driving. Furthermore, it can all be fitted into an annual vacation, or within a school holiday period as a one-way drive using a hire vehicle, with a flight home at the end. Those daunted by such a long drive will find travelling just a few sections an equally rewarding experience.
Location: the east coast of Australia
Length (total): Melbourne to Cooktown: 3,944 km
Length (by section): Sydney to Cairns: 2,407 km
Melbourne to Eden: 556 km/7 hours
Eden to Sydney: 478 km/7 hours
Sydney to Brisbane: 926 km/12 hours
Brisbane to Townsville: 1,335 km/18 hours
Townsville to Cooktown: 649/9 hours.
Stanwell Tops
Suggested return journey: return inland from Cairns via the Kennedy Highway to Four Mile Scrub National Park; Kennedy and Gregory Developmental Roads to Millchester, Gregory Developmental Road to Clermont; Gregory Highway to Springsure; Dawson Highway to Rolleston; Carnarvon Highway to Surat; Surat Development Road to The Gums; Leichhardt Highway to Goondawindi: Bruxner Highway to Tenterfield; New England Highway via the Hunter Valley to Newcastle; Pacific Highway to Sydney; Hume Highway to Melbourne.
An alternate inland route, which is shorter and on bitumen all the way, is to follow Bruce Highway south from Cairns to Townsville; take Flinders inland to Charters Towers; south along Gregory Experimental Road and Gregory Highway to Springsure via Clermont, Capella and Emerald; Dawson Highway to Biloela; south along Burnett Highway to Kingaroy; Bunya and Warrego Highways to Toowoomba; New England Highway to Newcastle via Warwick, Armidale, Tamworth and the Hunter Valley; Pacific Highway to Sydney; Hume Highway to Melbourne.
Features/attractions: coast towns and resorts of the NSW South Coast, Central Coast and far North Coast; the Gold Coast; Brisbane; the Sunshine Coast; the South Burnett region; Capricornia Coast; The Whitsunday Islands; other islands of the Great Barrier Reef; Cairns; Atherton Tablelands; Daintree rainforests
Minimum duration (one way): 7 days
What You Will See:
Melbourne to Bega: take Princes Highway out of Melbourne and travel east through Gippsland. This route passes the turn-offs to Phillip Island; the Victoria snowfields; Wilsons Promontory; Gippsland Lakes and passes through Traralgon, Morwell, Sale, Lakes Entrance, Bairnsdale, crossing the NSW border inland near Genoa. On the way in to Eden is the turn-off to Ben Boyd National Park (picturesque Twofold Bay; Boydtown historic ruins).
Broulee Island
Bega to Sydney: this section passes through the sleepy towns of Pambula, Merimbula, Bega (cheese factory) and the turn-off to Tathra (historic wharf). From Bega or Tathra the coastal road is recommended. It takes in Mimosa Rocks, Wallaga Lake and Bermagui. The highway is re-joined near the quaint villages of Tilba Tilba and Central Tilba. Continue north to Tarooma and Moruya, where again the recommendation is to take the coastal road via Broulee to Bateman's Bay alongside one of the most picturesque sections of the NSW coastline. Before reaching Nowra, the road passes through Ulladulla and the turnoffs to St. Georges Basin and the Jervis Bay region, which have much to offer the visitor in the way of scenery and places to see. Pacific Highway continues north to Sydney via Wollongong and the Shoalhaven and Illawarra districts.
Hawkesbury River
Sydney to Brisbane: proceed north via Pacific highway to Newcastle via the Central Coast. Follow Pacific Highway north to the Qld border, passing through the coastal resort towns of Nelson Bay, Forster/Tuncurry, Port Macquarie, Nambucca Heads, Coffs Harbour, Yamba, Evans Head, Ballina, Byron Bay (the most easterly town in Australia), Tweed Heads and the inland towns of Kempsey, Taree, Grafton, Maclean and Murwillumbah (Mt. Warning). Across the Qld border are the string of coastal resort towns which make up the Gold Coast, and the forested mountains of the Gold Coast hinterland.
Hervey Bay
Brisbane to The Whitsundays: Proceed north via Bruce Highway, passing the Sunshine coast hinterland on the left and Sunshine Coast townships on the right. Beyond the historic towns of Gympie and Maryborough is Hervey, the step-off point for whale watching, Fraser Island and Tin Can Bay (wild dolphin feeding). At Bundaberg the highway travels inland through sugar cane growing country and the towns of Gin Gin, Childers and Miriam Vale. A detour to the coastal towns of Agnes Water and 1770 is highly recommended. After Gladstone and Rockhampton and the coastal resort town of Yeppoon, the highway moves inland again for the least interesting sector of this drive. Bruce Highway rejoins the coast at Mackay. At Proserpine, a sugar town on the way to Bowen, is the turn-off to The Whitsunday Islands.
Hamilton Island
The Whitsundays to Cooktown: Return to Prosperpine and take Bruce Highway north towards Bowen. After Bowen, the next major town is Ayr, some 83 km from Townsville (Magnetic Island). The drive north from Townsville to Cairns passes through Ingham, Cardwell (Hinchinbrook Island), Tully (waterfalls; turn-off to picturesque Mission Beach and Dunk Island), Innisfail, Babinda (Babinda Rocks) and Gordonvale on the southern outskirts of Cairns. Cairns is the tourist centre for the far north coastal region, and tours to the Gt Barrier Reef, Kuranda and the Atherton Tablelands depart from Cairns. Cook Highway north leads to Mossman (Mossman Gorge; Daintree rainforests), Port Douglas, Cape Tribulation and the Heritage listed Daintree Rainforests.
Mission Beach
Driving to Cooktown on the sealed Peninsula Developmental Road involves a slight double back from Mossman to the old mining town of Mt. Molloy, then north to Cooktown. The Coast Road through Cape Tribulation is 81 km shorter but is unsealed for 80km, and may be closed during the wet season. Cooktown is as far north as the bitumen goes. The tip of Cape York (686 km north of Lakeland Downs), can only be reached by 4-wheel drive vehicle, and only then in the dry season. The section of Peninsula Developmental Road that leads to the tip of Cape York branches off the Cooktown road at Lakeland Downs.


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Vendor: Cisco
Certifications: CCNP Wireless
Exam Name: Implementing Cisco Unified Wireless Voice Networks (IUWVN) v2.0
Exam Code: 642-742
Total Questions: 185 Q&As
Last Updated: Sep 15, 2018
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Google today launched Android Pay in Australia, the second in the Asia-Pacific region after Singapore. Android Pay is the third mobile based payment service to launch in Australia this year, with Samsung Pay and Apple Pay making its way to the country earlier in the year.
Right now, Android Pay in Down Under supports American Express debit and credit cards, but support for MasterCard cards will also be added to the service. Android Pay is supported by 25+ banks and credit unions in the region including ANZ, American Express, MyStateBank, and Teachers Mutual Bank. Don't be fooled by number though, as ANZ is the only major bank in that list.
A complete list of support banks and credit unions can be found here. Google notes in its announcement that support for cards from Bendigo Bank and ING Direct will also be added to Android Pay soon.
Contactless payment is already supported by a wide variety of retailers in Australia such as Domino's, 7-Eleven, Coles, and more. Android Pay support for in-app payments will also be coming in a few days in apps like EatNow, Hotel Tonight, Deliveroo, and others.
[Via Google]


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The NYPD has released a fact sheet explaining what classifies a shooting in the city, after former Police Commissioner Ray Kelly questioned the department's shooting statistics.
Kelly argues the force routinely fails to classify people who have been grazed by bullets as shooting victims.
But, Tuesday night the NYPD released a fact sheet that states the classifications, saying police-involved shootings and self-inflicted shootings are not included into shooting statistics.
The department also commented on shooting statistics, saying shooting homicides are up 22 percent and stabbing homicides are down by 40 percent.
The NYPD says the statistics reflect normal crime trends during a time of historically low numbers.


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It's easy for someone who is experiencing thinning hair to feel alone. With all the media surrounding gorgeous celebrities, we are hit with pictures of beautiful people with beautiful hair left and right. Maybe even in our immediate circles, we tend not to notice the issues others are dealing with, as we become so consumed with our own problems.
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We're here with Trevor McGregor of JoyRide, to talk about the new changes made to the Fullmetal Alchemist Trading
Card Game. Also with us here is 'Team Hammergirl', the top eight FMA-TCG players of 'Hammergirl Anime' -
Rochester, NY's premiere anime and japanese culture store. This is in regards to the recent changes made by JoyRide to Gluttony Big Fists, Envy Copycat, Edward Elric Researcher, Library Ruins, Challenge the Sun, and Sneak Thief.
Trevor: Thanks for having me.
Sneak Thief has been said to be CRD'ed due to the card advantage it creates. The advantage: -1 attachment for an opponent, +1 attachment for the player, for one card - is no more of a card advantage than Quick Draw. Why the hate?
Trevor: That is really comparing apples to oranges and not apples to apples. You'd want to compare Sneak Thief to something like Oops or Bull's-Eye or even Aflame. Aflame is pretty close to Sneak Thief, it takes away a permanent from your opponent and gives you an advantage - all for one card. Aflame, however, is much more situational and is not long lasting. You play Aflame, get rid of attachments, get a strength bonus, be done with it. It is also situational, you must be in a battle with the character bearing the attachments you want to kill. Sneak Thief you keep the attachment to use against them plus you can do it in the Main Phase when everyone is fair game.
Lust and Psiren have the same basic ability as envy / gluttony. will they be CRD'ed? If not, why not?
Trevor: Both of those are level 3 leaders and are not able to put into any other decks, plus they are less universally useful.
What other cards are you 'looking at' in terms of possible CRD / bans?
Trevor: Since we keep printing location control counters we're obviously keeping an eye on them. Cards, like Challenge the Sun or Catch the Train, will always be watched since it actually goes around how the game works. There is an attachment in development that plays in the search phase, we'd keep an eye on that as well. Then we keep up with the popular cards, just keep an eye on them. Usually, though, we don't look to change things.
Why weaken Gluttony, Challenge the Sun, and By the Order all at once? This really seems to hurt Rebel, without the payoff. Do they get a lot of 'love' in upcoming sets?
Trevor: By Order wasn't changed per se, a rule was changed because of an omission to the original rulebook and that made By the Order too powerful. We changed that -but By the Order was only that way for a few months though. As to CTS and Gluttony, they each have their own issues separate from each other, obviously combined they are even stronger. To answer the follow up, that (character kill) isn't exactly what FMA the show is like or how the game was set up to be. Character kill is obviously an option, but it shouldn't be the easiest option, which in some cases it had become.
Errated cards seem to be moved from 'essential tier 1 cards' to tier 3, where things 'like the Mark of the O', while CRD'ed, are still great Tier 1 cards. why the decision to change Envy / Gluttony / Ed so heavily? (follow up from another player) Why not just add a discard cost, or something to give a 'card disadvantage' for the cost?
Trevor: the issue with them isn't card advantage, it is cherry picking your best cards and having 6 of them instead of 3. One of our playtesters put it the best, a little blunt, but still valid: "you don't errata card for power level if you don't want to make them weaker". I still think Gluttony is really good for rebels, I think Envy can be good in the right deck.
There's a lot of discard pile removal. was that an early shot against things that are currently CRD'ed?
Trevor: It was more a shot at what I like to call the 'in-house meta'. Someone in-house used Lust a lot, others didn't like it, bam, discard pile removal. That goes all the way back to before Premier was printed. As for the 'in-house meta' that applies to all games. It is actually funny how some cards come about - certain designers like to abuse certain things, others write counters, lots of fun.
Will we see any targetted main phase attachment destruction?
Trevor: Yes, one of the upcoming brotherhood cards does something like that, which was designed/printed without knowing we would ban Sneak Thief.
There are leaders (ALA, Greed) which are seen by the meta as 'not Tier 1' (Interviewer's note: What are you talking about, Expert Shadow is awesome). Also, in the show, many characters fall out of the spotlight (Cornello, Maes). Will we be seeing leaders to 'bump up' the less popular leaders, and will we continue to see leaders for characters that aren't in the show anymore?
Trevor: Yes and yes - I can't really say more than that. (and what are you talking about, my Greed/Toughness - 9 Deadly Sins deck is sure tier 1, well maybe 1.5 - 9 Deadly Sins, baby, 9 is the new 7)
The promos from World's (int. note: they ran out of the promos given away at World's, and gave 'rainchecks'), when are they being sent out?
Trevor: Some of them are already sent out, the others go out on Monday.
Will there be a movie set?
Trevor: I hope there is a movie set. We want a movie set, the people who own the movie want one but there are things to be worked out first. Both sides want to make it happen.
How many sets do you have planned out?
Trevor: we're working on Sacrifice and the set after that. Right now we have four sets planned for 2007 just like in 2006.
Who's on the list for new leaders? Any new Sins?
Trevor: We have two new leaders in Sac (one new and one redone), and then four on the books for the set after Sac but none of them are Sins.
Say something about football!
Trevor: Broncos 17, Steelers 9. Football is dead to me (not really). Ben (int. note - Trevor has been publically designing a card, using 'Ben Roethlisberger', a football player, as the interim name) is becoming a well-known character in FMA that is going to be new to the Rebel faction. Good stuff.
Spoil something!
Trevor: have you guys seen Rose's Baby yet? 1 cost, 0 s, 1 w, 0 a, Battle Wits Set: Target other attacking zealot gets +2 to one attribute. This ability can be played from home. "And thank you...for you baby's cry," - Edward Elric
Thank you, Trevor. That'll wrap it up for our interview with Trevor McGregor. Thanks as always, and we look forward to more great releases from Joyride Studios!
Anime Hi-Res Pictures:
- perfect for wallpapers!
- great pics of the ladies!


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"All I Want For Christmas Is You" At Firstdraft Gallery, Sydney
I was asked to participate in a show at Firstdraft Gallery with a video on the following concept:
"Pop music is an arena for the spectacular intersection of the common and the divine. So as we have branded and adorned ourselves with religious devotion, these gods and goddesses that captivate and elevate us are fantastic constructions that chant ideological slogans from ineffable, mediated stages. As Beyonce, Mariah Carey, Whitney Houston, Justin Bieber, Justin Timberlake and countless others play out mythical intimacies in their music (and their twitters), we, the listener and the fan, create the atmosphere of simulacra that provides sustenance for pop stardom. In one sense, fan clubs - Rihanna Navy, Directioners, Beliebers - enslave their ghostly icons, coveting and re-constructing the minutiae of their every recorded act in globalised acts of fictionalisation. The pop identity is thereby splintered or refracted millions of times through mass dissemination, ever organically developed and respawned atop and away from its source."
The Sydney based gallery organised the one night event on December the 6th 2013.
Posted by Oscar B.
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Enteric-coated Mycophenolate sodium
Enteric-coated Mycophenolate sodiumfortic (EC-MPS) is an enterie formulation of mycophenolate sodium (a prodrug of MPA). MPA reversible inhibits the inosine monophosphate dehydrogenase and the pathway of guanosine nucleotide synthesis which affects B and T lymphocytes whereas other cell types can utilize salvage pathyways for purine synthesis. The coating of mycophenolate sodium should reduce the gastrointestinal side effects [59]. In renal transplant recipients a dosage of 720 mg EC-MPS twice a day was therapeutically equivalent to MMF 1000 mg twice a day with comparable safety profile [60].
Dosage recommendation in HTx recipients is 720mg twice a day either orally or intravenously. Optimal measurement of EC-MPS plasma concentration due to its delay in reaching maximal blood concentrations compared to MMF, is yet not clarify (C0, C2, C4, C6).
Proliferation signal inhibitors
Proliferation signal Inhibitors (PSI) (also named mammalian target of rapamycin (mTOR) inhibitors) include two important drugs currently available for organ transplantation: Rapamycin (Rapa) or Sirolimus (SRL) and Everolimus (EvE). Four decades ago Rapa was extracted and its antifungal effects reported [61]. Intensive research resulted in the discovery of the target of rapamycin named mTOR. mTOR is a serine-threonine kinase which is a transducer of information from growth factors and energy sensors within the cell. Both drugs form a complex with the intracellular binding protein FKBP-12, (similar to FK 506) but contrarily to TAC the PSIs inhibit the activity of mTOR. This leads to an arrest of a cell cycle in the mid-to-late G1 phase [61, 62]. While FK 506 is suppressing lymphokine production and blocking activation of T-cells, PSIs inhibit cells proliferation by impairing their response to growth-promoting lymphokines [63, 64]. They are also used in other areas of medicine like oncology or interventional cardiology (drug eluting stents).
Rapamycin (Rapa) is a macrocyclic lactone with antifungal, antibiotic and IS properties. It was discovered in 1965, extracted out of soil taken from Rapa Nui in New Zeeland [65]. Its IS effects were discovered in the 1990s [61]. During the approval studies for Rapa the anti-tumor effects of Rapa and its analogues like EvE were found introducing them in oncology and for the prevention of restenosis after percutaneous coronary angioplasty.
Rapa has structural similarities to FK 506 binding protein but it forms complex with FKBP12 which results in an inhibitor of the mTOR [66]. This leads to suppression of T and B cells and decreases the population of dentritic cells who present antigen to T cells during activation [67].
The bioavailability of Rapa is 20% and decreases with food rich in fats (see 3.5.2); 92% of Rapa binds to albumin, is metabolism extensively in intestinal wall via p-glycoprotein and in the liver by CYP3A4. Seven major metabolites are known but 90% of the IS activity is done by Rapa; close to 90% is eliminated by the liver only 2% by the kidney. In contrast to EvE half-life time of Rapa is about 62 hours ± 16 hours allowing one single daily dose.
A loading dose for Rapa on the first post-transplantation day is recommended; in renal transplantation the loading dose should be 3 times the estimated maintenance dose (normally 2mg), in HTx recipients 15mg are given followed by a maintenance dose of 5mg and further guided by trough levels. The total dosage must no exceed 40mg per day; if a higher dose is needed it should be divided over a period of 2 days. In children with a body weight below 40 kg initially a loading dose of 3mg/ m2 and a maintenance dose of 1mg/m2 daily is recommended. If CNI therapy is reduced, Rapa dosage should be increased according to the targeted trough levels. In patient with severe hepatic impairment Rapa dosage should be reduced.
Routine clinical measurement is done with chromatographic methods. Major side effects of Rapa are swelling in different tissues, prolonging healing of wounds, increasing cholesterol and triglyceride levels, proteinuria as well as blood pressure. Rapa induced interstitial lung disease like pneumonitis have been observed [68-70]. When combined with CNIs, CNIs dosage reduction is necessary otherwise worsening renal function will develop. Rapa recommended blood trough levels in combination with CNIs is between 4 to 12 ng/ ml, without CsA a four times higher Rapa dosage might be needed (CsA/CNIs suppress the metebolizion of Rapa), the recommended blood trough levels is increased between 12 to 20 Ng/ ml depending on the time after transplantation. This is also the reason why Rapa intake when combined with CNIs is recommended four hours after CNI administration. Otherwise Rapa enhance the toxic effect of CNIs with an increased risk of CNI induced hemolytic uremic syndrome, thrombotic thrombocytopenic purpura and thrombotic microangiogiopathy. Drugs inducing CYP3A4 (Rifampicin) will decrease, strong inhibitors (Macrolides, Ketoconazole, Itraconazole) will increase Rapa blood levels. Similarly to CNIs grapefruit juice increases plasma concentration of Rapa. According to the last ISHLT report Rapa is currently used up to 20 % of HTx recipients [12].
Everolimus (EvE) is an analogue of Rapa and differs only by one extra hydroxyethyl group at position 40; still this leads to some differences. EvE blocks growth factor-mediated proliferation of cells including vascular smooth muscle cell through a CA2+ independent signal [71]. Following oral intake EvE is rapidly absorbed and reaches its maximal blood concentrations after 1 to 2 hours. The oral bioavailability is approximately 30% [72-75] and it is altered by food; a high-fat meal is slowing down the absorption of EvE. It is recommended that EvE is taken constantly either with or without food. EvE undergoes major metabolism with none of the metabolites reaching significantly IS activity. Its half-life time is 28 hours and compared to Rapa (62 hours) much shorter. Initial dose may be 0.75 mg twice a day, no loading dose is necessary.
EvE has a more rapid time to steady state compared to Rapa (4 versus 6 days). EvE binds to plasma proteins about 75% to 80% and is mainly eliminated in the liver, only 5% are extracted across the kidney. In patient with severe hepatic impairment EvE dosage should be reduced. PSIs and CNIs are metabolised by cytochrome P4503A4 (CYP3A4) isoenzyme leading to reduced clearance of EvE when CNI is given. Pre-clinical research reported of no nephrotoxicity of EvE [76] but when it was first clinical used combined with full dose CsA it showed worsening renal function [77, 78]. For that reason FDA approval was refused, but the European Medicine Agency (EMEA) approved EvE for further studies. In a prospective multicentre study the possibility of dose reduction of CsA combined with EvE resulted in stable renal function without loss of efficacy [79]. Further trials confirmed this [41, 42, 80]. Besides this interaction drugs who strong induce CYP3A4 will decrease, strong inhibitors will increase EvE blood levels. Reported EvE blood trough levels are within 3 to 8 ng/ ml. Drug monitoring is done by HPLC coupled with mass spectrometry and an immunoassay is being developed. EvE showed to have antiproliferative effects delaying the onset of cardiac transplant vasculopathy and reducing the rate of CMV infections [77, 81]; it is increasingly used, up to 2.6 % in HTx recipients in the years 2008 and 2009 [12]. Due to the favourable effects it may be used in children and is currently investigated (RAD 2313).
Immunosuppressive regimes
At the beginning little was know about interaction, side-effects and combination of IS drugs. Nowadays with many different IS drugs acting at different receptors and stages of the immune system more effective and less toxic regimes may be used.
It was revealed that the combination of different acting IS drugs with adjusted dosage enhance their effectiveness and reduce toxicity. To avoid nephrotoxic side effects of CNIs and to achieve a high IS, over 50% of the centres reporting to the ISHLT are using an induction therapy (20% using polyclonal antibodies, 30% use IL2 receptor antibodies) [12]. Conventionally for maintenance therapy patients are treated with a triple drug regimens, consisting of a CNI (CyC, TAC), antiproliferative agent (AzA, MMF) and corticosteroids. Shortly after the introduction of CsA in 1980 Griffith and colleagues used CsA in combination with low-dose steroids in HTx recipients, tapering steroids from 200mg per day to 15 mg per day similar to the regime used by Starzel in renal and liver transplant recipients [82-84]. Combining CsA, AzA and Cortocosteroides, commonly called triple-drug immunsupression, evolved and showed improved survival for short, medium and long term follow-up [85, 86]. It increased 1 years survival after HTx from 60% to 80% and became the standard regime not only in the US but also in European countries over the next 30 years [87, 88]. The triple-drug protocol, even if modified (many centres skipping corticosteroids after a certain time) is still used around the globe. Adding a forth drug to the regime has been reported but became not standard [19, 89].
Still due to the well know side effects of IS, associated with a significant morbidity, discussion about reducing IS will continue. Reduce IS therapy with a mono or dual drug regimes are investigated. Recently a retrospective study involving 150 patients within 28 days after HTx maintaining recipients only on monotherapy with TAC has been published [90]. One has to notice that in IS monotherapy compliance is paramount and could result in a disastrous outcome. The conviction of currently experts in the field of IS is, that today's "standard" immunosuppression may be replaced by IS individualized for each patient on the basis of genomic profile, baseline risks for rejection and infection, and perhaps serial assessments of immune response after transplantation [91].
Immunosuppression for acute rejection
Different principles of IS treatment after organ transplantation have been established over time. After HTx numbers of rejection episodes and immune reactivity are highest within the first 3-6 months. Therefore one of the principles is to use the highest intensity of IS immediately after surgery and decrease it over the first year (Induction therapy (see 3.1), corticosteroid weaning (see 4.1.2); lowering blood concentrations of IS agents). The second principle is to rather admit more IS drugs with non-overlapping toxic side effects at a low dose rather than a higher and more toxic dose of a single drug. Therefore monitoring of the IS drug trough levels is of great interest; special caution must be paid to interaction of the drugs (lowering or increasing the blood levels) or i.e. diarrhea when orally taken. The goal is to avoid over-immunosuppression, which leads to infection and malignancy. This on the other hand may lead to late acute rejection episodes even if it is rare [92]. Corner stone of the treatment are corticosteroids, both oral or intravenous, ATG (see 3.1 Polyclonal Antibodies),
IL-2 receptor blockers (see 3.2 Interleukin 2 receptor antibodies) or murine monoclonal antibody (see 4.2). The type of treatment depends on clinical status of the recipients (if the rejection is hemodynamic compromising [reduced cardiac output, decreased pulmonary artery saturation, elevated wedge pressure, reduced cardiac index]) the histology degree and severity of the rejection. Moderate to severe rejection episodes need therapy: intravenous corticosteroids for three to five days, intensify oral maintenance IS therapy and eventually change to another protocol; if there are recurrent rejection episodes TAC or EvE may be considered. In patients with hemodynamic impairment additionally polyclonal or monoclonal antibodies or plasmapheresis should be kept in mind.
Corticosteroids inhibit the synthesis of cytokines, but the exact mechanism of action in solving acute rejection is not jet completely understood. Steroids suppress besides i.e. IL-6, interferon gamma, TNF, the production of IL-1 resulting in a diminished production of IL-2 by activated T cells. In animal models it was reported that steroids induce lymphocytolysis which was not proved in humans. Synthetic pharmaceutical drugs with corticosteroid-like effect are used in a variety of treatments. Prednisone is the most used synthetic steroid and is five times more potent compared to cortisol. Its bioavailability is 70% when orally taken and it is metabolised in the liver. Natural steroid hormones have a very short half-life time, synthetic steroids like prednisone have a half-life time of 1 hour. The side effects of long-term corticosteroids are commonly known; dosage reduction below the cushing threshold or even weaning them off are valid options. Nevertheless for acute rejection episodes intravenously high dose corticosteroid treatment is still necessary and effective. After solving the acute phase of the rejection episode orally corticosteroids should be introduced to treatment for at least some time or if already part of the maintenance IS protocol its dosage should be increased.
Corticodsteroid weaning
Over 85% of the centres reporting to the ISHLT are currently using corticosteroids within the first year after HTx, after 5 years about 50% are still using corticosteroids [12, 46]. The negative side effects of steroids are well known such as i.e. weight gain, glucose intolerance, dyslipidemia, osteoporosis, or cartaract. Most of the rejection episodes are within the first year after HTx and most of the steroids can be taken off over a course of a few months. The rationale for diminishing the overall use of corticosteroids is the availability of new IS agents acting more selective compared to synthetic corticosteroids. Numerous protocols were established, most of them use a high dosage of corticosteroids intra-operative (when starting reperfusion) and within the first days (as part of an induction therapy). When oral dosage is given different possibilities are available such as i.e. fixed dose of 15 mg per day or prednisolon 0.05 to 2mg/kg divided by one to four doses per day. After weeks of months the dose is reduced achieving a dose below the cushing threshold. Some study groups report to take off corticosteroids as early as 8 weeks after HTx [90] or over a course for several months following a simple weaning protocol guided by daily cortisol measurments to avoid onset of adrenal insufficiency (level > 8 ^g/ dl continue to wean, otherwise continue steroid therapy) (Baran DA. A prospective trial of steroid discontinuation in stable heart transplant patients as guided by serum cortisol measurement. International Society for Heart and Lung Transplantation 2009, Abstract 431). Other weaning protocols decrese the daily prednisone dosage by 1mg each month starting at month 6 post HTx [93].
The question why long-term use of corticosteroids is still that present may have several reasons i.e. avoiding adrenal insufficiency or other potential effects when treatment is stopped but also the 'heritage' of this therapy as steroids once were nearly the only immunosuppressant choice for transplant recipients.
Monoclonal muromonab CD3 antibody
Muromonab-CD3 (brand name: OKT3) is a monoclonal antibody against CD3 antigen resulting in an inhibition of T-cell function by down regulation of CD3 positive cells. It was the first monoclonal antibody to be approved for clinical use in humans. Similar to polyclonal antibodies its way of administration is only intravenously. Recommended dosage is 5 mg per day, in pediatric patients (< 30kg body weight) initial dosage may be lowered to 2.5mg per day. The human body will produce human anti-mice antibodies, as OKT3 is like a mice-antibody explaining the loss of effectivity if given repeatedly. Toxic side effects besides the well know from all IS agents (higher infection rate higher rate of lymphoproliferative disorders) have been reported: cytokine-mediated first-dose reaction, pulmonary edema, aseptic meningitis, haemolytic-uremic syndrome. The first-dose reaction may include fever, rigors, nausea, vomiting, and diarrhea which will decrease with repeated exposure. Nevertheless steroids, antihistamines and antipyretics should be given along with OKT3 to minimize these side effects. It takes about a week after ending the OKT3 treatment until the T cell function returns to normal.


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Orphaned. Facing jail. An Amish home is Jacob's last chance. When orphaned Philadelphia teen Jacob Marshall gets in trouble with the police, he has two options – go to juvenile detention or work on a farm outside of the city. But when he chooses the latter, Jacob gets more than he bargained for as he struggles to find his place in an Old Order Amish community in Lancaster County and with Thomas Mast, the straight laced Amish family man who is charged with keeping Jacob in line. Caught between the light and dark, will Jacob be able to face his demons and put his past behind him and become simply Amish, or will his pain prove stronger than the faith of the Amish community he's grown to love? A Lancaster Amish Home for Jacob is an exciting story of a boy finding himself and his place in a new, strange world.
A Lancaster Amish Home For Jacob
Orphaned. Facing jail. An Amish home is Jacob's last chance. When orphaned Philadelphia teen Jacob MOrder Now!
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On Sat, 2007-09-15 at 06:40 +0200, Máirín Duffy wrote: > Hi folks, > > I installed Fedora 8 Test 2 last night, and after updating it I took > some time tonight to take screenshots of the application menus to show > what the icons look like in a default installation of Fedora (well > except I installed Inkscape, sorry, I couldn't live without it for that > long. :) ) > > Overall, the icon coverage looks pretty good and the icons for the most > part are pretty consistent, but there are still some icons that have > problems. They either look fuzzy, or do not fit the icon theme / don't > look polished. Some of this may be due to technical or packaging issues > I think? I noticed the puplet icon gets less blurry if you increase the > size of GNOME panel. But some issues may be due to there not being an > appropriate icon available or the upstream icon not being that great. > > Is it worth it to take some time to make sure the initial set of icons > in the menus for a default Fedora install all have perfect and > consistent coverage? Is it possible to address all these issues? > > Here's my 'hit list' of icons to address with screenshots, if so: > > https://fedoraproject.org/wiki/Artwork/F8Themes/IconReview_Fedora_8_Icon_Review > > ~m > Hi Mo, many of the blurry icons are from bluecurve (especially those in 'System' menus) which has only 20x20 and 24x24 sets. I think these could be fixed easily by creating 22x22 set out of 20x20 by adding a 1px transparent border. Dunno, however, how to take care of the applications' upstream icons, whether create a 22x22 icons with same look as the original or whether make their gnome/mist variants and contribute them to gnome icon theme... Also, as we target Echo icon set on Fedora 9 we should also consider these and decide which applications' icons create in addition to those in icon naming specs. Should we rather focus on apps in Live CD, or rather take care of categories (like icon for graphics-raster, graphics-vector, graphics-viewer, office-wordprocessor,...)? Any thoughts on these? Martin
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Abby's Guide
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PDA Operating Systems
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The best PDA may be the one you put away when work is over.
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You knew it was coming…a completely portable pc that operates on Windows XP with the functions and more of a PDA with cell phone and laptop capacity. With a price tag of $1500 in the US, this little powerhouse should keep us at work even when hiking Everest, or on a cruise through the Caribbean. I don't know what this says about leisure time, but if your work requires you to be out of the office, but near all the information and power you need to perform that job, then this could be just the thing.
If DualCor Technologies has anything to say about it, the word at the end of 2006 will be "handtop"…combining the convenience of a PDA with the power of a desktop. Ready for launch the DualCor cPC is an all in one that measures 6.5 inches by 3.3 inches and offers standard computing with a 40 gb hard drive, internet accessibility, email and a good chat on the phone. You can run the whole Microsoft Office Suite, Tablet C and a ton of other applications, and then send your hard work via email.
The cPC has both a 1.5 Ghz and a 400 MHz processor with a gig of RAM. The screen is 5 inches with 800 by 480 resolution. You also get three USB high speed ports, headset, phone jack, Compact Flash, a microphone and mouse controls. If you want there is available a keyboard as well to enable easy input.
The advantages to the medical, research, engineering, retail and military fields are stunning.
My only concern is that we have enough problems getting away from it all as it is. We are not all that great at establishing boundaries of work and play. Now we may never be able to "get away". Let's only hope there's room on the DualCor dPC for some "Free Cell".
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4 Goals for Two Thousand and Sixteen...
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I was only just saying how I need to make time to read more, I feel like I just don't have the time but I seem to find time for social media and Netflix somehow!ReplyDelete
Good luck on your driving test, You can do it! I found it easier when I kept the date of the test to myself and then it felt like there was less pressure if others didn't know about it. Was nice coming home with the surprise when I passed too!
Tell me about it! I can always find time for Netflix. Thank you :-) I don't plan on telling anyone apart from my parents so hopefully this will take the pressure off a little! xoDelete
I really want to attend a blogger event this year too, i know i will be super nervous though! xReplyDelete
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To be honest, there isn't many here in the North East but I just know I'd be so nervous to attend! xoDelete
I really enjoyed reading this article. Thanks for sharing it. Keep up the good work.ReplyDelete
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Hello! Thanks for checking out my blog :) Feel free to leave me a comment or question and I'll reply as soon as possible. You can also tweet me! @jennywilsonxo


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Designs by Stonescapes is proud to offer both residential and commercial hardscaping design and installation services for customers throughout the Denver metro area. Many who live in the region are drawn to its natural beauty, and hardscaping is an excellent way to incorporate these natural elements into your outdoor space while creating a true living area that will make you love your home even more.
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When it comes to most things in life, the Goldilocks theory works best for wine temperature: not too hot, not too cold – you want it just right. The question then becomes, what exactly is "just right."
There are actually two areas we need to explore for wine temperature: storage and serving. What is the best temperature to store your wine and what is the optimal temperature for serving wine. Remember, it's a guide to help you best enjoy your favorite bottle of wine. A few degrees here or there won't ruin your experience, but we want you to experience these wines the way they were intended.
Let's start with storing the reds, whites, and sparkling wines.
Stability is key. Too much fluctuation in temperature can lead to cork damage. Keep your bottles away from sunlight, and heat exposure, and give them balanced humidity: not too hot, not too cold, but just right.
- Ideal storage temperatures for red wine – 50-55 degrees F
- Ideal for white wines – 45 degrees F
Quick Reference Serving guide:
- Light whites, roses, and sparkling wine are best served — 40 to 50 degrees F
- Full-bodied white and light fruity reds are best served — 50 to 60 degrees F
- Full-bodied reds and ports are best served — 60 to 65 degrees F
Should you invest in a wine cooler?
It depends. If you keep a number of bottles on hand, consider purchasing a wine cooler to help keep your wine at a controlled, perfect temperature. Unlike optimum wine temperatures, prices on these can fan the range. Keep it simple, and keep your wine at its best until you're ready to pour. Plus many of our older Minnesota homes have a built-in wine cellar — the basement root cellar. See what you can do to convert that area. Sounds like a nice fall project.
Tip: If the bottle is not cold enough to drink, put the bottle on ice for an hour.
If the bottle is too cool, simply decant, and let it sit at room temperature for about an hour. It will all even out.
Founded in 1934, Haskell's has championed fine wines for over 80 years. We have 13 wine stores in Minnesota, two delis and one restaurant. As one of the top wine shops in North America, Haskell's is known for legendary service and one of the finest collections of wine, beer and spirits. Led by Chairman and CEO Jack Farrell, and the Farrell family, Haskell's continues to be at the forefront of the wine scene throughout the world. Haskell's also can ship wine, beer & spirits all throughout the world, the U.S. and we deliver locally.


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PASADENA --An SUV driven by a pregnant woman jumped a curb Sunday at a Pasadena bus stop, trapping a man underneath the vehicle, officials said. The crash occurred about 11:20 a.m. at North Lake Avenue and East Orange Grove Boulevard, when the woman's SUV ran up on the curb at a bus stop, according to Lisa Derderian, a spokeswoman for the Pasadena Fire Department.
A man waiting on the bus bench was trapped under the SUV and had to be extracted by emergency personnel, said Derderian. The victim, described as in his 20s, was conscious when taken to a local trauma center, Derderian said, but the full extent of his injuries were not known.
The cause of the accident was not immediately known and investigators were at the scene midday. No arrests were made as of noon.
The driver of the SUV was a pregnant woman in her 20s, according to Derderian, and she was taken to a hospital for observation.
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