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David Blunkett's 'Review of education structures, functions and the raising of standards for all' is a significant document. It highlights and reinforces the weaknesses of the current mishmash of arrangements for overseeing the development and improvement of all schools. More significantly, for the purposes of this blog post, it provides a real sense of direction about the likely shape of Labour's education policy and priorities a year out from next year's general election.
A strong welcome
Blunkett's proposals offer the opportunity to bring coherence to school improvement. The principle of school autonomy remains – not a surprise really since Blunkett did much to affirm the autonomy of schools when he was Secretary of State for Education: substantially raising the level of financial delegation to schools. But the vision is for autonomy to operate within a context of partnership and collaboration. Getting this balance right is strengthened by David's recognition that the actions of one school can impact on another. Education improvement has to be more than a zero sum game – we need all schools in every area to move forward. So the plans to amend schools admissions, enforcement and appeals procedures and integrate place planning are welcome. And (hallelujah!) there is a single framework for overseeing the progress and development of all schools – irrespective of their type or status.
The document also contains some innovative ideas. For example, encouraging and enabling academies to move in and out of chains to bring greater geographical coherence. Or focusing funding agreements on outcomes and renewing them every three of five years – as recommend by the RSA/Pearson Academies' Commission. The proposals for commissioning new school places rightly maintain a strong competitive ethos but bring coherence to a system which in many areas has been thrown into chaos by the ad hoc establishment of free schools. The creation of Education Incubation Zones would encourage the education system to continue to evolve in order to meet the changing demands of 21st century society.
Three caveats
I have three reservations about the proposals. I can see the case for kitemarking the supply of major school improvement providers – though I am not convinced that the market is broke. A better way forward might be for the kitemarking to be a voluntary arrangement in the first instance.
I also wish that the review had grasped the nettle of clarifying the role of the Office of Schools Commissioner and making it a statutory independent function. There is case for a revamped Schools Commissioner role to include the functions of the Schools' Adjudicator – thus creating a single regulatory focus.
The approach towards the Pupil Premium is also slightly worrying. Yes, there is evidence that not all the money is being well used at present. But we are on a journey here. The role of the Education Endowment Foundation, the impact of the Ofsted inspection regime, the role of John Dunford as the Pupil Premium champion and the work of a good number of local authorities means that the additional funding is increasingly being better targeted and used. There is a growing focus on impact, so we should be wary of making major changes to the system at this point.
Be prepared
What does Labour need to do next? The Party must learn from its experience of coming into government in 1997. More was achieved more quickly in those policy areas where the detailed policy thinking and work had been done in advance. So having produced this paper Labour cannot rest on its laurels. Here are five ideas on some next steps the Party might take:
- Develop its education narrative – the Blunkett reforms are right but they need to be communicated in a way that parents, the media and the wider public can understand. Simple key messages might be:
- Schools improve at a faster rate when they work together
- Pupils enjoy better learning when teachers have the opportunity to work with staff from other schools on planning and reviewing lessons
- There needs to be a fair and level playing field when it comes to admitting pupils to schools and assessing how well schools are improving
- Supporting schools to improve is best organised locally rather than being decided by Whitehall Ministers and officials
- Draft instructions to counsel – for those not familiar with the Whitehall policymaking process this means preparing a policy document that enables the specialist lawyers to prepare a Bill for Parliament. This would provide a discipline for Labour to define the role and powers of the Director of Schools Standards (DSS) and the education panels that would support them. It would also help to think through how the proposed public duty for local authorities, schools and other providers to cooperate with the DSS in brokering collaboration would work.
- Consult with the Local Government Association on the new school oversight arrangements – particularly in relation to potential groupings of local authorities and relations between a DSS and constituent authorities. I don't take the view – put forward by Jonathan Simons and Sam Freedman on Twitter – that local authorities are being completely written out of the script. As suggested in the Blunkett review it might make sense to take the boundaries of Local Enterprise Partnerships (LEPs) as the starting point – since this would help to integrate work on careers advice and post-16 provision. However, there are already some groupings of education authorities developing – particularly in London – and so there is also scope to explore whether these might provide a basis for some of the new arrangements.
- Set up some demonstration models – it might be possible for local groups of Labour local authorities such as in Manchester (where local authorities and schools have a strong history of working together collaboratively on school improvement) to appoint a DSS in a shadow form. However, any such scheme might be stymied if the Government's formally appointed Regional Commissioner for overseeing academies refused to collaborate with the initiative.
Where authorities could progress the Blunkett agenda without hindrance would be encouraging the creation of Community Trusts for groups of primary schools. Several authorities have already or are currently working with their schools on forming local clusters. Legislation relating to Trust schools is already on the statute book and so the organizational vehicle is there to create formal groupings of primary schools. The only restraint is that it is difficult for voluntary aided faith schools to be formally part of such a Trust – because they are already a Trust. This needs discussion with church representatives – we should be encouraging faith schools to work with other local schools rather than just retreat into faith-based academy chain enclaves.
- Assess the costs – the coalition will no doubt try and dub the proposals as bureaucratic and costly. But the Blunkett plan would be able to build on the savings made from scrapping the regional Commissioner posts. There are also substantial resources going into employing a small army of civil servants and brokers who are monitoring, tracking and, where necessary, intervening in the 3,000 plus academies. These costs need to captured and quantified. It might also be possible to make savings from the Education Funding Agency budget. The more transparent financial regime advocated by Blunkett allied with the adoption of prudential corporate governance practices could reduce the need for the extensive financial monitoring that the government has put in place.
And for its next trick…
The Blunkett review marks a big step forward in Labour's thinking. For its next trick it might want to think about how to turn the Ofsted regime (which has become an excessively high stakes regime) into something that retains rigour but is more supportive of school development!


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subset: commoncrawl


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Archive for May 2016
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Cathy looked at herself in the bedroom mirror. Legs that looked pretty condemn adequate for a thirty-five year obsolete -- even if she did father to wear thick tights to hide the scars from the operations. Eighteen months of physiotherapy and put to use after the operations had been beneficial. Her compute looked graceful good again now as well. She had to use a all of get up on her deal, and the surgeon said she'd probably always have to, but she felt good about herself again.
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In one of the most shocking elections in over a hundred years, the Trump train managed to derail Hillary Clinton and become the president-elect. While the ones who voted for him hope for a better America, there are chances that he might not be as good as they thought. Here's 5 ways Trump can bring problems to USA and lead country to a worse situation.
1.Infuriating a One-Time Allie
One of the promises that Donald Trump made to the country was he was going to put an end to illegal immigrants flooding through the borders. To keep his promise, Trump proposed that he will build a wall and make Mexico pay for it. It is hard to imagine that Americans really believed this promise, but apparently now that Trump is the president-elect, people better start paying close attention to his plans. Mexico was in the process of building stronger relations to the United States since Obama took office, but it appears Trump has little concern about destroying a relationship at the expense of building his wall. If the USA does in fact build a wall, America will surely be on the road to ruin possibly faster than the 4 years Trump will be in office. If we lose Mexico as a country that supports America, the list of remaining supporters will be next to nothing.


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© 1998-2018, Palestinian Media Watch, All Rights Reserved.
Reproduction permitted, with the following attribution:
© Palestinian Media Watch – www.palwatch.org
PA depicts a world without Israel
Denying Israel's right to exist
PA TV: Israel attempts "to prove historical fables and promists that exist in their extremist minds alone, about... a people who never owned this land"
Official Palestinian Authority TV - Apr. 28, 2014
Official PA TV News reported on Holocaust Memorial Day
PA TV newsreader:
"Even as Israel commemorates the day known as Jewish Holocaust Day, it perpetrates a new Holocaust each day against our people; it persecutes them, discriminates and treats them with racism."
[Photographs of Hitler and images from the period of the foundation of Israel (Ben Gurion, war images, etc.) appear in the background during the report]:
PA TV narrator:
"Even as the Israelis commemorate Holocaust Day – which all human conventions denounce and condemn because it is contrary to the nature of all mankind – our people remember the holocausts and massacres committed by the descendants of the survivors of the Holocaust [perpetrated by] Nazi Germany. Israel has not learned the lesson from what happened to them and to other human beings. To the contrary, during its wars it carried out executions, murdered civilians, bombarded buildings with missiles, burned Arab villages in 1948 and set up detention camps. Between massacres, Tel Aviv established its control and occupation of this land, to compensate for its losses and for the suffering caused by Hitler's Germany and the rest of the world, where they had been persecuted and discriminated against. The strange thing is that the occupation state copied these racist acts, and gave our people, the owners of this land, a taste of them, in order to prove historical fables and promises that exist in their extremist minds alone, about a land without a people for a people who never owned this land…
[Ben Gurion understood that the Palestinians would never accept the Israeli narrative, and therefore decided to suppress and defeat them time after time, to make them accept the Israeli narrative.]
Decades later, the situation has not changed, and Tel Aviv is still making our people taste tragedy – by oppressing the Palestinian people and undermining its awareness of its tragedy, in which Tel Aviv plays the part of the executioner; while it ignores its own tragedy, which occurred decades ago – the same tragedy that the world opposed – while it turns a blind eye to the tragedy of our people that stands firm on its land."
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Before downloading your checklist you'll need to confirm your email address.
Please click the confirm link in the email I just sent you. This saves you from spam.
Speaking of which, if you don't get my confirmation email, check in your spam, or promotions folder.
(While you're waiting, I thought you might enjoy this story from The Life and Times of Col. Daniel Boone)
Boonesborough was stirred by a startling disaster. The settlement was greatly in need of salt, and, as it was a work of extreme difficulty and danger to secure its importation from the Atlantic States, the much simpler method was resorted to of having it manufactured at the Blue Licks, where there was such an abundance of brackish water that the work was easily done. Collecting some thirty men, Boone set out for the Blue Licks which were at no great distance, and they began immediately the process of evaporating the water and collecting the saline deposit.
Salt is one of the prime necessities of life, and they were desirous of making enough of it to last them for a long time to come. The operation of salt-making is not a complicated one, even in these modern days, and there was scarcely the work to keep the whole thirty men busy all the time. As might be supposed, Boone spent many hours in hunting. It is probable that the Indians, learning of the weakened condition of Boonesborough, had determined on attacking it with a force which promised to insure its capture. For this purpose they gathered two hundred warriors and started for the settlement, without Boone or any of his party suspecting the danger that was moving down upon their friends. Still further, knowing that the unsuspicious white men were engaged at the Licks, the large force of Indians turned in that direction and advanced with the noiselessness of so many shadows.
Daniel Boone, at that juncture, was alone, hunting in the woods, when he came face to face with the two hundred warriors, who appeared as suddenly as if cast up by the earth. Without stopping to parley, Boone whirled about and started on a dead run, darting in and out among the trees, doing his utmost to dodge the bullets that he expected would be sent after him, and to place himself beyond sight of the Indians, who were desirous of securing so renowned a man as he. But Boone was not so young as when he had his former desperate encounters with the red men, and the dozen warriors who instantly sped after him were among the fleetest of their tribe. The pioneer made good progress, but as he glanced furtively over his shoulder every few seconds, he saw that the savages were gaining rapidly upon him, and his capture was certain. He held out as long as there was the slightest hope, but soon abruptly halted and surrendered.
There is something singular in the consideration which the Indians showed Boone on more than one occasion. It will be remembered that when he and Stuart were captured, they were kept day after day, until they gained a chance to escape; and, in the present instance, the captors conducted him back to the main body, where he was still held a prisoner, no harm being offered him. This was at a time when the fury of the savages was stirred to the highest point against the settlers, and when the treacherous bullet, the crashing tomahawk, the deadly knife and the smoke of the burning cabin were more typical of the manner of warfare, than were any of the amenities of civilized, contending forces.
It may have been the Indians recognized the importance of the capture they had made in the person of the great Daniel Boone, for they treated him kindly and conducted him back to the Blue Licks, where the rest of the settlers were encamped.


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It's been a massively busy day at the Carolina Horse Park, with Advanced dressage running amidst CIC3*/CIC2* show jumping and CIC* cross country. Kim Severson and Cooley Cross Border ultimately prevailed in the sandbox, scoring 27.1 to just edge Lauren Kieffer and Veronica for the lead.
In a special edition of today's Friday Video presented by World Equestrian Brands, we have footage of Kim and Cooley Cross Border's test courtesy of our friendly neighborhood videographer David Frechette.
Many pairs in this division are gearing up for a spring CCI4*, with Cooley Cross Border aiming for his four-star debut at the Rolex Kentucky Three-Day Event. Lauren Kieffer and Veronica, who scored 27.2 for second place, are aiming for their first appearance at the Mitsubishi Motors Badminton Horse Trials.
Lillian Heard and Share Option — another Rolex-bound pair — sit in third place on 29.1, with Will Coleman and Boris O'Hara in fourth on 31.5. Kristin Schmolze and Ballylaffin Bracken sit tied for fifth place with Courtney Cooper and Who's A Star on 32.2. Click here for more dressage videos.
The Advanced division goes cross country at the very end of the day tomorrow at 4 p.m. EST. Advanced cross country will not be live streamed, but we'll have the scoop here on EN for all of you following along with this division. Click here to catch up on all of EN's Carolina coverage so far. Go Eventing.
Carolina Links: Website, Entry Status, Ride Times, Live Stream, Schedule, Orders of Go, Live Scores, EN's Coverage, EN's Twitter, EN's Instagram


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According to The Enquirer, Jennifer Lawrence and Nicholas Hoult are planning to get married! Despite having dated for a while, broken up, and gotten back together, the two have decided they cannot be apart.
Nicholas is already rumored to have proposed to Jennifer Lawrence, who has been spotted out with a diamond ring on her wedding finger: 'I don't think there's going to be a big announcement. They just want to slip away and get married in quiet. They'd much rather run off somewhere and marry quietly and then have a family get together, one in Kentucky and the other in London.
Having a lavish Hollywood wedding is the last thing they want. Jen says planning it all and working out a guest list would drive her crazy. It would be so stressful deciding who to invite, so as not to offend anyone in Hollywood.'
They parties in both the UK and America, but they won't be discussing their lives together in public: 'They are fiercely private and have no intention of becoming a high-profile Hollywood couple, which is why they're not making a big noise about it.
But I can confirm that Nick has popped the question and Jen said yes. I think they like the idea of letting everyone speculate whether or not they are even engaged..'
The two stars met while shooting 2011's X-Men: First Class and bonded over their relaxed natures. They are both much more at home in comfy clothes and enjoying the great outdoors than they are glammed up for movie premieres. Jen wants to start a family soon: 'It's so weird for a 22-year-old to say it. I do feel the reason I was put on this earth is to be a mother, which is why it's funny for me to end up with such an overwhelming career.'


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Image Management's exclusive interview with Nitin Mantri, CEO and Business Partner of Avian Media.
N Madhavan: Cold Calling Culture of PR Agencies Needs to Stop
What annoys Hindustan Times' N Madhavan about the PR industry? Find out in our exclusive interview.
Infographic – How To Engage Journalists Through Social Media
As social media evolves the way we communicate, it has also altered how we pitch to journalists. This infographic, based on a survey of UK journalists by Text 100, gives lessons about how PR professionals should approach journalists on social media.
6 Most Common Mistakes by PR Pros While Writing a Press Release
Here are the six cardinal sins to avoid while writing a press release.
Delhi CM Sheila Dikshit Says Public Relations Professionals Have an Enormous Responsibility
At the PRCAI Annual PR Summit 2012, Chief Guest Smt. Sheila Dikshit urged PR professionals and the media to be more responsible in terms of how they communicate.
Access Based Journalism Is Dead – What PR Professionals Should Know About the Evolving Media Landscape
At the PRCAI Summit 2012, a panel of journalists discussed the evolving media scenario and its impact on public relations professionals.


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Planes,trains,tubes,taxis, buses and a mono rail
It only took three and a half days to get to Goa. Our original flight via Aer Fungus was cancelled, so we re booked at 5 am to Gatwick with Monarch. After a five hour delay, we were re routed to Birmingham. Rather than get the free bus to Gatwick and get stuck there, we got the train to Euston (beautiful Virgin train, well quick) and a tube and another train to heathrow, just in time to miss our connecting flight...
Gina managed to rebook us for the following evenings flight, which after queueing for five hours was cancelled at the last minute. Free hotel care of two hours queueing at another BA conter, and we returned to Heathrow just before 6am the next day. NO seats but we could wait on standby... on the gate side fortunately as we had no hold luggage.
Tears in our eyes as we were allowed to board followed by a four hour wait on the tarmac.. whilst queuing for more de icing, the auxilary engine failed, than heathrows portable power supply failed, then we were towed to their main supply that also failed. We all got out and bump started the pig in the end.
We arrived in Mumbai at 4am their time - man so busy, when do they sleep. Taxi from International airport to domestic one and six hour wait for next flight to Goa (regardless to say two hour delay...
At Goa, man in a Newcastle shirt met us and took us on a two hour terrifying ride across country. Goa is not third world - it is the third world, the biggest truck on the road wins, de rigeur is to overtake on blind corners. Somehow it works, but having lost two nights pre paid accomodation and being ripped off by the pyseudo geordie taxi man and not having slept for a few days made me start to wonder what we were doing.
We left the posh hotel on principle (three nights for the price of one..) and moved next door into a co co hut - a bamboo shed on stilts. Several Kingfisher beers, good curries, swmming in warm warm waters later, this place is starting to grow on me. There is no infrastructure, fly tipping must be an olympic sport (Portuguese are real amatuers by comparison!!), mayhem between taxis rickshaws, motorbikes and people on tiny roads - but it works, and if you want anything, its around.
We are now in Arambol, on the North coast of Goa, a small town full of life, staying in an apartment hanging over the Arabian Sea, a nice breeze, fine life! I have just booked a 350cc Royal Enfield to go North to Fort Teracol - it's only 20 years since I rode a big heavy motorbike - with Owl on the back through crowded streets!!!!!!!!!!!
Wish me luck, Stu x


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Just what it requires to achieve a garage door setup isn't really in fact really included though these action in it could puzzle a person that is not actually a do-it-yourself type individual. Recognize that a garage door is a large item as well as may be harmful to do such a task if the guidelines or treatments supplied the door do not comply with the word for word.
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For the many components, hands-on garage doors are doors that are elevated as well as decreased without help from an electrical motor as well as the like. Light-weight garage doors may be inadequate for particular garages or for proprietors that would certainly such as truly thick timber doors.
When it comes to setting up hands-on doors there are a number of actions in the procedure that require being complied with in series. When those are mounted they must be a taken care of safely to the door's jamb.
Constantly inspect making certain these springtimes are packed right into each brace, then examine making certain that the drum on the left side is set up initially and afterward safeguard the drum on the appropriate side. After those actions have actually been completed is currently time to safeguard television retainer as well as wind the spring snugly. Deal with the spring as a harmful item, as it could be under a great deal of stress.
A do it on your own individual need to make certain that he or she has a companion to help in the setup when it comes to automated doors. It may be an excellent suggestion to pay an installer to come out and also do the door if you have a companion neither experience. If you are still video game, nevertheless, start by attaching door tracks properly to just what's called a "drive device" and afterward start to put together the remainder of the track areas and also placed them with each other.
Inspect completion of each track and also make certain that a placing brace has actually been a taken care of safely as well as affix the entire point to the beam of light that exists over the garage door in the garage ceiling. Ensure that electric motor installment is done inning accordance with guideline then attach it firmly to the ceiling. Run all-electric motor cables from the electric motor to the wall surface button then set up any kind of sensing units down below the door.
After finishing all these actions, it is after that time to wed up to the garage door to the garage door opener. Always remember that power is associated with this installment along with a garage door spring that could be under a great deal of stress. Collaborate with an aide to do the garage door set up procedure as well as attempt never ever to avoid an action in the installment guidelines for any kind of factor.
For the many components, hands-on garage doors are doors that are elevated as well as reduced without help from an electrical motor and also the like. Lightweight garage doors may be inadequate for specific garages or for proprietors that would certainly such as actually thick timber doors.
Inspect the end of each track and also make certain that an installing brace has actually been a taken care of firmly and also connect the entire point to the beam of light that exists over the garage door in the garage ceiling. After finishing all these actions, it is after that time to wed up to the garage door to the garage door opener.


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India is quickly becoming a rising star in the world of affiliate marketing. Due to the high human capital and the low cost of labor, working with Indian teams to develop and implement affiliate marketing solutions is a cost-effective practice for global businesses.
When looking for new opportunities to increase revenue and grow a business, affiliate marketing in India can be a reliable investment for companies all over the world.
Indian digital work teams have come a long way over the past decade. As internet commerce booms and replaces traditional offline forms of marketing, companies are constantly on the lookout for a cheap, reliable way to get their products into the hands of consumers. Affiliate marketing in India allows companies to create marketing programs for their products at rates lower than anywhere else in the world.
Contrary to the fears of some, Indian marketers are proficient in English, tech-savvy and often come from other job markets that require a wealth of intelligence and skill in their prospective studies and fields.
As a result, there are Indian affiliate networks launching seemingly every other week. Many of these networks are able to create systemized, performance-driven marketing campaigns for companies who are looking for a long-term and cost-effective affiliate marketing solution for their businesses and products.
A majority of these networks often have the same level of experience creating websites, ad creatives, writing copy and assisting with PPC and SEO as their American counterparts. Additionally, many of these networks utilize the well known American tracking platforms, making them an attractive and efficient alternative.
Some of the more promising ones and their top campaigns:
• Shoogloo Network (British Airways, Jet Airways, Yatra)
• vCommission (Maakan.com, Snap Deal)
• DGM India (Naukri.com, MakeMyTrip, Met Life)
• and an up-and-comer, Canada-based Ad Indian.
Of course, like any other business decision, there are some fundamental questions to ask yourself, such as…
• How do you know which ones to trust?
• Which ones are legit?
• Will they comply with the laws that govern your product/campaign? The answer is rather simple: DO YOUR DUE DILIGENCE.
• How long have they been around?
• What brands are they marketing?
• Are they VC funded or being run out of a boiler room in a remote village (do they have boiler rooms in India…hmm?) with little supportive infrastructure?
The legit Indian affiliate networks are highly trained, have experience with affiliate marketing, very fluent in the technology piece and are able to assist clients in all parts of the world.
Through email, AIM and Skype, Indian affiliate marketing teams are able to work across continents with clients to provide streamlined affiliate marketing plans, cost-effective service, and a "potentially" flawless marketing campaign.
Affiliate marketing in India is on the rise. With customizable solutions that can benefit individual affiliate publishers and companies alike, turning to India for cost-effective technological solutions makes perfect sense for anyone interested in affiliate marketing.
Ricky Ahuja is the CEO of Affiliate Venture Group specializing in outsourced program management, PPC and SEM.
Download the entire FeedFront issue 14 here – http://www.scribd.com/doc/52425616/FeedFront-Magazine-Issue-14
FeedFront issue 14 articles can be found here as well: http://feedfront.com/archives/article00date/2011/04


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Bergenia cordifolia
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Keywords: angiosperms, bergenia cordifolia, biological, biology, botanical, botany, close up, close-up, elephant'ss ears, flora, flowering, flowers, horticultural, horticulture, nature, perennials, petals, pink, plant, spring
Licence fees: A licence fee will be charged for any media (low or high resolution) used in your project.


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SKOPJE, Macedonia – A private plane traveling from the north Italian city of Treviso has crashed in a mountainous region of Macedonia, killing all six people onboard.
Police told The Associated Press that four Italian nationals and two from Kosovo were killed in the crash south of the capital Skopje.
The pilot had requested to land at Skopje's airport to refuel but didn't report any emergency. Shortly after, the plane lost contact with the airport.
Authorities said they had no other details of the passengers or where the plane had been heading. They described it as a light aircraft made by the U.S.-based Piper Aircraft Inc.
The plane was found shortly after nightfall, several hours after the pilot's last communication with the airport in Skopje.


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originally posted by: Wang Tang
originally posted by: Willtell
Philosophy as a scholastic pursuit or enterprise is one thing and philosophy as a way of life is entirely different.
I ascribe to the latter reality. The former is a construct of facts and history the latter is a construct of beliefs and experience.
Therefore, the important question seems to be: what the constructs of ones philosophical beliefs are.
I like the way you just laid this out. I would like to think my question as my attempt to break away from philosophy as a scholastic pursuit and commit to philosophy as a way of life.
I disagree with your conclusion though
originally posted by: fatkid
a reply to: luthier
I can make a bench out of a tree am I a God to the bench?
Also, please link something scientific that says "apes" which I would assume you mean chimpanzees have the vocal cords to produce words as we know them.
Apes already communicate vocally.
So what you meant to say is, you can *modify* a ape to speak via genetic engineering.
Humans are a long way away from *creating* complex life capable of abstract thought.
We will probably create true AI before we will be able to create organic life grown from two created cells into something like a human.
Once this happens, you would have to ask the created creature if it thinks you are God or not.
What is the Most Important Philosophical Question


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FORMULATION AND PERFORMANCE EVALUATION OF ESCITALOPRAM LOADED BIO-NANO SUSPENSION USING A NOVEL BIO-RETARDENT FROM PIPER NIGRUMHTML Full Text
Deepika Raina and N. V. Satheesh Madhav*
DIT University, Makkawala, P. O. Bhagwantpura, Dehradun - 248 009, Uttrakhand, India.
ABSTRACT: Nanoparticles represent a promising drug delivery system of controlled and targeted release. The current research work was to explore novelistic route for targeting to brain through ear by formulating nanosuspension using escitalopram as a model drug permitting better control over depression. Depression is the second most prevailing disease after cardio-vascular diseases. The delivery has overcome the dose dumping problem in case of oral system. In this research work significant effort was made to explore novelistic platform for ear to brain. Bio-nano suspensions were prepared by using a biopolymer which was isolated from berries of Piper nigrum. Eight formulations were prepared of different ratios i.e. 1:0.5, 1:1, 1:2, 1:3, 1:4, 1:5, 1:7, 1:10,. The formulations were subjected to various evaluations, including pH, % transmittance, Content uniformity, ex-vivo, stability, release for over 36 hours. Different formulations of Escitalopram out of which F1 (1:0.5) was found to be the best formulation having r2 value of 0.9905 tT80: 22 hrs and best fit model was found to be higuchi matrix, and mechanism of transport was anomalous transport which was calculated by bits software. According to the in-vitro results obtained it can be concluded that significant amount of drug reaches to the brain via external acoustic meatus. The demand for curbing depression and other mental health conditions is on the rise globally. Nano suspensions are distinctive and commercially feasible approach to solve the problems of hydrophobic drug such as poor solubility and poor bioavailability.
Keywords: Acoustic meatus, Nano-suspension, Higuchi matrix, Anomalous transport.
INTRODUCTION: Escitalopram is the most selective serotonin reuptake inhibitor (SRI) antidepressant available 1. Although pharmaco-logical and psychological interventions are both effective for major depression, antidepressant drugs remain the mainstay of treatment.
During the last 20 years, selective serotonin reuptake inhibitors qqqq (SSRIs) have progressively become the most commonly prescribed antidepressants. Escitalopram, the last SSRI introduced in the market, is the pure S-enantiomer of the racemic citalopram. Escitalopram has no or very low affinity for other receptors (alpha- and beta-adrenergic, dopamine (D1-5), histamine (H1-3), muscarinic (M1-5), and benzodiazepine receptors) 2. Depression is a significant contributor to the global burden of disease and affects people in all communities across the world. Today, depression is estimated to affect 350 million people.
Depression is a common mental disorder that presents with depressed mood, loss of interest or pleasure, decreased energy, feelings of guilt or low self-worth, disturbed sleep or appetite, and poor concentration. Moreover, depression often comes with symptoms of anxiety. At its worst, depression can lead to suicide. Almost 1 million lives are lost yearly due to suicide, which translates to 3000 suicide deaths every day 3. External Acoustic Meatus: has length 24mm along posterior wall it is not a straight tube (S shaped) it has 2 parts, outer part-directed upwards, backwards and medially inner part-directed downward, forward and medially. The cartilaginous canal, the skin contains sebaceous and apocrine glands with many hair follicles. Together, the hair follicle, sebaceous gland, and apocrine gland are termed the apopilosebaceous unit.
Auricle: The auricle, a part of the external ear, consists of elastic cartilage covered by skin. The lobule consists merely of fibrous tissue and fat. The auricle is connected with the fascia on the side of the skull by unimportant anterior, superior, and posterior auricular muscles, which are supplied by the facial nerve. The auricle is supplied by both cranial (auriculotemporal nerve from cranial nerve V; probably also twigs from cranial nerves VII, IX, and X) and spinal (lesser occipital and great auricular) nerves 4.
Blood Supply of External Canal: Laterally supplied by the post auricular and superficial temporal arteries. Medially it is supplied by deep auricular artery which is a branch of first portion of the internal maxillary artery. This deep auricular artery supplies the tympanic vascular ring. Veins from the external canal drain into the superficial temporal and post auricular veins. The post auricular vein connects to the sigmoid sinus via the mastoid emissary vein, this anastomosis provide a route for infections of the external ear to spread to the intra cranial cavity 5.
Ear canal is having a unique histology, blood supply, nerve supply like mandibular (auriculo-temporal branch), vagus nerve (auricular branch), internal maxillary (tympanic branch), glosso-pharyngeal nerve connections present in auditory canal. The unique platform can be used for targeting brain by various Active Pharmaceutical ingredients used for brain diseases having various drawbacks of more adverse reactions and withdrawal symptoms. As on date the oral and parenteral dosage form exist for the antidepressant drug in the market but these molecule upon administration in long term therapy produces short term ADR's and Long term ADR's. Delivery of API molecule to the brain for the management of depressive disorder is significant, minimizes the ADR and side effects of therapeutic molecule and offer good patient compliance through this novelistic approach. The unique anatomical arrangement of blood vessels and sinuses in the human skull and the brain, the prevalence of a high density of skin appendages in the scalp, extra cranial vessels of the scalp communicating with the brain via emissary veins and most importantly, the way that the scalp is used in Ayurvedic medical system in treating diseases associated with the brain show that a drug could be trans cranially delivered and targeted to the brain through the scalp.
The emissary veins draining blood from extra cranial sites into the intracranial sinuses pierce a series of foramina present in the cranial bones. Scalp veins communicate with the sinuses of the brain via emissary veins. There are thirteen emissary veins connecting extra cranial sites of the head with intracranial sinuses. Seven major sinuses within the skull are inter connected by a number of anastomosing veins, which finally drain intra cranially into jugular veins giving ample scope for the diffusion of the drug molecules into the nerve tissue of the brain. These anatomical arrangements of the vascular system of the brain are made use of in the investigations to establish the brain targeted trans cranial route (TCR) of drug delivery 6.
In recent years, there has been a considerable interest in the development of novel drug delivery systems using particulate delivery systems like nanoparticles. Nanoparticles represent a promising drug delivery system of controlled and targeted release. In this context, nano suspensions will be effective in increasing the solubility, bioavailability of poorly soluble drugs. A large proportion of new chemical entities coming from drug discovery are water insoluble, and therefore poorly bio-available, leading to hurdles in formulation development efforts.
There are number of formulation approaches like micronisation, solubilization using co-solvents, precipitation techniques etc., to resolve the problems of low solubility and low bio-availability. Each of them has their own limitations. Other techniques like micro emulsions, solid dispersions and inclusion complexes using cyclodextrins even though showed increased solubility, but not applicable for drugs which are insoluble in both aqueous and organic media. The next development step is transformation of the micronized drug to drug nanoparticles and nano suspensions.
Nanoparticulate drug delivery system may offer plenty of advantages over conventional dosage forms which include improved efficacy, reduced toxicity, enhanced bio distribution and improved patient compliance. Nanosuspension technology offers novel solution for these poorly soluble drugs. Nanosuspension consists of pure poorly water soluble drugs with or without any matrix material suspended in dispersion. Nano-suspensions are distinctive and commercially feasible approach to solve the problems of hydrophobic drug such as poor solubility and poor bioavailability 7.
Isolation of Bio-Material Fruit of Piper nigrum: Piper comes in two types black and white piper obtained from the ripen and after the separation of pericarp of fruits of piper nigrum, family piperaceae. It constis of phenolic esters, ethers, pyrrolidone, volatile oils and ligands 8. Isolation of bio-polymer from white pepper (Piper nigrum), which is a flowering vine in the family Piperaceae 9. White pepper corns were powdered and soaked in Methanol: Glacial acetic acid: Concentrated Sulplhuric acid (85:10:5). Solution was kept on the magnetic stirrer for continuous stirring for 30 minis then filtered and 10 ml of sodium hydroxide was added.
To the above solution cold water was added and precipitate was obtained, Kept in refrigerator for 24 hrs centrifuged at 3000rpm for a period of 15 minutes, dried and stored. The bio polymer was subjected to various spectral analyses including UV, IR, SEM. Nanosuspensions were prepared by sonication method using Piper nigrum as retardant and with other co-processing agent. Eight formulations were prepared viz. 1:0.5, 1:1, 1:2, 1:3, 1:4, 1:5, 1:7, 1:10. The formulations were subjected to various evaluations, including pH, % transmittance, Content uniformity, Ex-vivo, stability release for over 36 hours.
Nano-Sizing of Escitalopram: To 100mg of Escitalopram, 5ml methanol was mixed and triturated. 5ml distilled water was added slowly and sonicated for 5 cycles (1 cycle for 3 min.). After each sonication cycle absorbance and %T were measured. It was then micro centrifuged. Supernatant and residue were collected. Residue was dried and nanoparticles were recovered 10.
Drug Excepient study: The pure drug along with the formulation excipients were subjected to interaction study by U.V Spectroscopy. The study was carried out by dry and wet mixing of the drug and excipient in ratios of 1:1, 1:3, 3:1. Both the mixture was stored at room temperature and at 55°C for three days. The dilution was made by the solvent and the sample was scanned at λmax using UV spectroscopy.
Permeability: Drug solution of 1mg/ml was prepared and 1ml drug solution poured in donor compartment. pH 7.2 buffer was prepared and was kept in the receptor compartment. The sample was replaced completely every time. Egg membrane was used as a biological membrane as it mimics the action of the ear biological membrane
Formulation of Bio Nano Suspension: Nanosuspensions were prepared by sonication method using Piper nigrum as retardant and with other co-processing agent like glycerin and dextrose as a nanosizent. Weighed amount of drug, dextrose and polymer was triturated together in mortar and pestle and kept on sonicator. Glycerin was added to above mixture in sonication mode. Eight formulations were prepared viz. 1:0.5, 1:1, 1:2, 1:3, 1:4, 1:5, 1:7, 1:10, 1:15, and 1:20. The formulations were subjected to various evaluations parameters
Physicochemical Characterization of the Bio-Polymer: The isolated bio-material was check for color, odour, taste, solubility, colour changing point, and viscosity. The biopolymer was also tested for the presence of carbohydrates and proteins.
SEM Analysis: The SEM analysis of the bio-polymer revealed that it has a smooth surface with no rough edges. It shows the smooth, amorphous nature of the bio-polymer. The bio-polymer showed a morphological structure similar to the polymers and hence it confirms the polymeric nature of the bio-polymer (Fig. 4).
In-vitro Adhesive Study using the Shear Stress Method: The adhesive property of the isolated biomaterial was determined by in-vitro shear stress method. Three different concentration of the biomaterial (1%, 3%, 5%) were placed between two glass plates and subjected to shear stress for assessment of in-vitro adhesive strength in terms of weight required for breaking adhesive bonds between the material and the glass plate after a specified contact time of 5, 10, 15 and 30 minutes.
Isolation of Bio-Material from the Fruit of Piper nigrum: The % yield for piper nigrum was found to be 15.2 ± 2.33% with a color changing point of 215 °C ± 5 °C. The bio-materials were purified and no presence of chlorides, sulphates and starch was observed (Table 1).
|Light brown
|Partially soluble in water
|Melting point
Nano-Sizing of Escitalopram: When a sample is subjected for measurement of % T at different wavelengths the percentage of transmittance reflects the percentage of the particles which are present in the mixture below 400 nm. Whereas the % blockade indicates the % particle which are above 400 nm and the data was correlated with the SEM analysis (Fig. 2).
|Drug:polymer ratio
|Escitalopram (mg)
|Piper nigrum Bio-polymer (mg)
|Glycerin µl
|Dextrose (mg)
|Distilled water (ml)
Drug Excepient Study: The drug interaction study revealed that there was no interaction between the drug and the excipients including the bio-polymers. This was proved by the result of the thin layer chromatography in which no change was seen in the RF value in the TLC method. Also there was no change in the ƛ max by UV method.
Value which was observed to be 289 nm prior to the test and after the test it was 289 nm hence confirming that there was no interaction between the drug and excipients. No observable signs of drug interaction were seen. It was concluded that none of the excipients had a detrimental effect on the drug and could be safely used for the formulation of the suspension.
Permeability: Egg membrane was used as a biological membrane as it mimics the action of the ear biological membrane. A permeation graph was plotted between concentration vs time, depicting the amount of drug permeated (Fig. 1).
Physico-Chemical Characterization of the Bio-Polymer: The isolated bio-material was light brown in colour, odourless, characteristic taste, partially soluble in water, colour changing point of 215 °C ± 5 °C. It had a viscosity of 1.44 cps, carbohydrates were absent while proteins were present. (Table 1) The IR spectra revealed the presence of amines, thiocarbinol (C=S), aromatic rings (1598.88 cm-1) and the presence of alkanes, alkenes (2925.81 cm-1) and nitro compounds (Fig. 1). These groups like the nitro groups indicate the mucoadhesive activity of the bio-polymer as these groups are observed in the mucoadhesive polymers like HPMC, polycarbophil (Fig 3). The isolated biomaterial was further evaluated for its adhesivity by using shear stress method.
Characterization of Drug Loaded Nano Suspension (Table 2):
pH Studies: value of pH was noted from digital pH meter. The method was performed in triplicate and mean value of pH was calculated and was found between 7.2-7.8 (Table 3).
TABLE 3: pH STUDIES
Dispersibility: Evaluation of dispersibility of nanoparticles was done by manual hand shaking method. 10 mg of accurately weighed nanoparticles were taken in test tube and dispersed in 10 ml of double distilled water. After dispersion of the nanoparticles time taken for settling of particles to the bottom of the test tube was noticed and redispersion of nanoparticles on shaking of test tube was noticed. Visual observation was done to investigate formation of any aggregates or precipitates after shaking.
Entrapment Efficacy: Entrapment efficacy was calculated to find out the amount of entrapped drug inside the nanoparticles. It was calculated by accurately weighing 5mg of formulated nanoparticles and dissolving them in 5ml of methanol. The solution was sonicated for 10 mins and kept for 24 hrs as such. After 24 hrs each solution was diluted upto 10µg/ml and was analyzed under UV at 289 nm against the blank methanol solution and drug content was calculated. Entrapment efficacy was calculated by following formula:
Entrapment efficacy- amount of drug in nanoparticles / drug added in nanoparticles × 100
Preliminary Method to Screen the Nano Particle Size Range by UV Method: Transmittance of the nanosuspensions was studied as preliminary study for the particle size analysis. It gave an idea regarding the particle size of the nanosuspensions formulation. Transmittance is based on the concept of Tindal effect which specify that when light of specified wavelength passes through the media containing particles less than or greater than specified particle range, the % blockage represent particle beyond size range at particular range whereas % Transmittance is considered that the particles lies above the size range at particular range. Transmittance of the formulation was studied by UV spectroscopy between 400-600 nm ranges keeping plain double distilled water as the blank. The reading showed the number of particles that allow the UV light to pass through it and rest of the particles showed the range of particles that blocked the light thus providing an idea of the range of particles in the nanosuspension (Fig. 2).
Particle Size (Size Distribution by Intensity): Preliminary study for particle size study by % transmittance was followed by Particle size range and size distribution study of the nanosuspension. Nanoparticle size was studied and average diameter range and intensity of the particles in particular size range was studied.
In-vitro Studies: The in-vitro release pattern of FA1-FA8 were studied by dynamic method and a graph is plotted between % drug release and time, r2 value t50 and t80 were calculated from the graph, which showed drug release ranging from 85-89% (Fig. 5 and 6).
Stability Studies: Stability studies were performed according to ICH guidelines. The formulations were stored in hot air oven at 37 ± 2 °C, 45 ± 2 °C , 4± 2 °C and 60 ± 2 °C for a period of 3 months. The samples were analyzed for drug content every two weeks by UV‐Visible Spectrophotometer at 289 nm. Stability study was also carried out by measuring the change in pH of nano-suspension weekly in terms of change in color, odour, taste, its entrapment efficiency, and in-vitro drug released.
SEM of Formulation: The SEM analysis of the formulation containing bio-polymer revealed that it has a smooth surface with no rough edges. It shows the smooth, amorphous nature of the formulation (Fig. 5).
DISCUSSION: This research work is focused to explore a novelistic platform for brain specificity via external ear canal by suitably designing an antidepressant loaded nano-suspension. As natural bio- polymers possess novel in-built properties like filmability, retardebility emulsifibility, suspendi-bililty and flow ability.
Hence, these polymers can serve as a potential bio-carrier or bio-inactive pharmaceutical ingredients in designing various drug loaded dosage forms, liquid dosage form and semi-solid dosage form. Many existing pharmaceuticals are rendered ineffective in the treatment of cerebral diseases due to our inability to effectively deliver and sustain them within the brain.
CONCLUSION: In recent years, there has been a considerable interest in the development of novel drug delivery systems using particulate delivery systems like nanoparticles. In this context, nanosuspensions will be effective in increasing the solubility, bioavailability of poorly soluble drugs. A large proportion of new chemical entities coming from drug discovery are water insoluble, and therefore poorly bioavailable, leading to hurdles in formulation development efforts. External acoustic meatus consist of unique histology and blood supply. It is highly enriched with dense neural network which in turn connects with the cranial nerve in medulla oblongata.
Our in-vitro release patterns reveal that over an extended period of significant amount of drug reaches to the brain. There are no pharmaceuticals designed specifically for brain targeting to treat the depression via ear. We have designed a dosage form to combat the disease and increase patient compliance thereby minimizing the incidences of dose missing which are relatively quite high due to busy schedule and long term therapy course thus prevents he precipitation of the disease from chronic stage. The long term therapy and multiple dosing is the main reason for the discomfort of the patient. All above mentioned problem can be overcome by the instilling of Escitalopram loaded nano-suspension in to the ear which is targeted directly to the brain via inter and intra neural pathway.
Ethical Approval: NA.
Clinical Trial Registration: NA.
ACKNOWLEDGMENT: The authors are grateful to the Vice chancellor of DIT University Dehradun. For providing immense support in carrying out the research work.
CONFLICT OF INTEREST: There is no conflict of interest.
- Bielski RJ, Ventura D and Chang CC : A double-blind comparison of escitalopram and venlafaxine extended release in the treatment of major depressive disorder. The Journal of clinical psychiatry 2004; 65(9): 1190-6.
- Cipriani A, Santilli C, Furukawa TA, Signoretti A, Nakagawa A, McGuire H, Churchill R and Barbui C: Escitalopram versus other antidepressive agents for depression. The Cochrane Library 2009.
- Marcus M, Yasamy MT, van Ommeren M, Chisholm D and Saxena S: Depression: A global public health concern. WHO Department of Mental Health and Substance Abuse 2012; 1: 6-8.
- O 'Rahilly R and Müller F: Basic human anatomy: a regional study of human structure. WB Saunders Company 1983.
- Thiagarajan B: Anatomy of external auditory canal a review from otolaryngologist's perspective. ENT SCHOLAR 2012.
- Pathirana W, Abhayawardhana P, Kariyawasam H and Ratnasooriya WD: Transcranial route of brain targeted delivery of methadone in oil. Indian journal of pharmaceutical sciences 2009; 71(3): 264.
- Debjit B, Harish G, Duraives S, Kumar K, Raghuvanshi V and Kumar KP: Nanosuspension-A novel approaches in drug delivery systems. The Pharma Innovations 2012; 1: 50-63.
- Rai N, Yadav S, Verma AK, Tiwari L and Sharma RK: Quality specifications on Piper nigrum-A spice and herbal drug of Indian commerce. International Journal of Advanced Food Science and Technology 2012; 1(1): 1.
- Khan IA and Abourashed EA: Leung's encyclopedia of common natural ingredients: used in food, drugs and cosmetics. John Wiley and Shah, C. S., and Qadry JS. A textbook of pharmacognosy. Messrs BS Shah 2011.
- Madhav NVS and Raina D: Formulation and evaluation of Duloxetine loaded bio-nano suspension for brain specificity via acoustic meatus. SOJ Pharm Sci 2017; 3(4): 1-5.
How to cite this article:
Raina D and Madhav NVS: Formulation and performance evaluation of Escitalopram loaded bio-nano suspension using a novel bio-retardent from Piper nigrum. Int J Life Sci Rev. 2017; 3(5): 60-66:.doi:10.13040/IJPSR.0975-8232.IJLSR.3(5).60-66.
All © 2015 are reserved by International Journal of Life Sciences and Review. This Journal licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License
Article Information
D. Raina and N.V. S. Madhav*
NRI Vidyadayani Institute of Science, Management and Technology, Bhopal, Madhya Pradesh, India.
07 March, 2017
11 May, 2017
16 May, 2017
31 May, 2017


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Apocalypto is a movie that's normally called "Mel Gibson's Apocalypto." That's a little ego-maniacal, so I refuse to call it that. Hey... I'm not baggin' on the guy for any of his drunken and bigoted and fundamentally religious flaws because all I care about is a d*mn good movie, and Mel can surely make 'em. The Passion of the Christ, removing myself from all religious opinions, was a great movie. And everyone knows that Braveheart is among the best movies ever, er, created.
In this film, he begins the ending of the Mayan civilization with a gaggle of peaceful natives (and yes, some hot native women) invaded by a hoard of warriors. The movie is detailed down to the skin art and foreign tongue (sub-titled), so you really get the sense of what it was like to be there. And you will be blown away when you see what happens to captives who are taken "down town"... brings a whole new meaning to "some heads are gonna roll." Shocking. And El Centro is literally amazing.
While I really did like this movie, I was a bit annoyed at a 24-hour foot chase that seemed to keep the pursuers trailing at exactly 100 yards behind the entire time (unrealistic for a movie that paid so much attention to realism). And I did, for some reason, expect this to be a much grander and larger picture; but in reality, it was all about the Indian in the photo and his plight to save his pregnant wife and kid.
FilmBender is Funny Movie Reviews. Check out the trailer and then watch the movie and relish in the fact that anyone can invade your village and f*ck up your day -- even Spain. Maybe Monday I'll continue the theme and review an alien invasion movie... I'm curious and all, but let's face it, if history serves us right, that would s*ck.


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Here's recent video from Fox News that shows how the small town of Lakewood Ranch, Florida has been transformed with Microsoft Tags, one of the 2D barcode standards that are out there:
Although 2D bar codes have been around for a very long time, their use has been limited to mainly tracking inventory and marketing metrics. But with the development of smartphones like the iPhone, Blackberry, and Android phones, these 2D barcodes are unlocking the enormous potential of informational access where none existed before. When smartphone owners scan these 2D barcodes using their phone cameras and a barcode reader app (usually free), they are instantly linked to online content that the creator of the barcode wants a person to see.
The barcodes are identical in function as hyperlinks and URLs are used on the internet, except that they exist in the "real" world, not the world wide web (www). They link what is OFFLINE to what is ONLINE. Never before has society had this type of access so readily available, and all that is necessary is to place these 2D barcode "tags" wherever people may want more information.
For instance, instead of placing an old menu outside a restaurant, the owner could have a 2D barcode made and place it outside. Once scanned, a visitor only only can have access to a menu with images of the food, but also a photographic tour of the restaurant or a welcome video from the chef inside. How much more inviting would that restaurant be to a visitor?
More importantly, that information can be carried away from the restaurant since it travels with the cell phone. Visitors are not confined to stay and look at a menu outside. They can quickly scan the barcode, and view the restaurant information elsewhere and when they would like.


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Pruning a HUGE sycamore
Another section by popular demand. If you want to talk about anything else that grows that is not livestock, herbs, fruit or vegetables here it goes.
Post Reply
Re: Pruning a HUGE sycamore
Have a think about planting ash as whips (available for the next few weeks as bare root and very cheap).These will grow like stink,can be coppiced to make a decent hedge even better if mixed with a bit of thorn,and will burn brilliantly with the minimum of seasoning.
Post Reply


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Any place is heaven if you are near me.
Thomas Chalmers.
Issue Number:
Edison Royal Purple Amberol: 29025.
Release year:
This cylinder has not been digitized for online access. Learn more about our "adopt-a-cylinder" program and to adopt this cylinder, use our credit card payment option or donate by check.
Year of release from "Edison Blue Amberol Recordings" by R. Dethlefson, v.2 (1981).
Baritone solo with orchestra accompaniment.
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Special Coll., Performing Arts Cylinder 10571
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March 4, 2017, 9:30 am-3 pm
- Peace United Methodist Church, 52497 275th Ave., Elgin, MN 55932
Google Map »
- Event Website »
- RSVP to Karen Stettler, LSP, 507-523-3366, email@example.com
Assessing Risks, Affordability and Land Access Options.
If you are an aspiring or beginning farmer looking to rent, buy or otherwise access farmland. Or if you are a beginning farmer looking to work with an established farmer this workshop is for you.
This workshop will focus on visioning, your experiences, finances and environmental considerations to help you consider what is possible as you seek land to farm. Each family will have a tool to help gain clarity.
There will also be ideas, advice and support from other farmers and professionals. Dean Harrington, a retired banker and guest speaker, will be on-hand to discuss building a proposal and relationship with the bank. Devon Ballinger, a beginning farmer will talk about her experiences looking for land. A light lunch will be served. The cost is $10 per person; $5 for additional family members
For more information, contact LSP's Karen Stettler at 507-523-3366 or via e-mail. More information on farm transition tools is here.


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NYC0712 108 Tschumi on LoEaSi
Building by star architect Bernard Tschumi, near Delancey St. According to a blog post on Dezeen it's supposed to be "a highly specific architectural statement that responds to the eclecticism of the historic Lower East Side". Somehow, I doubt it succeeds in that goal.
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Taken on December 25, 2007


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Strategic partnerships help SNPA members save money, grow revenue
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Because every newspaper printing operation has unique requirements, Southern Lithoplate, Inc. (SLP) forges strategic partnerships with industry leaders to create the most complete and cost-effective newspaper computer-to-plate (CtP) solutions. As the exclusive North American distributor of CRON-ECRM's thermal newspaper platesetter series, SLP is offering SNPA members a 5 percent discount on the purchase of CRON-ECRM hardware. This new CtP system provides a true alternative to thermal platemaking devices in the marketplace. Read more about this savings opportunity!
NRS Media will offer SNPA members a report that maps out their sales trends for the past three years by revenue, ad size and yield. The company is also preparing customized programs to help SNPA newspapers achieve increased short- and long-term revenue and market share.
SNPA is also working on exclusive arrangements to outsource production and editing tasks, a gateway for content sharing, cost-effective digital content, and a steady stream of best ideas and best practices.
For information about becoming an SNPA Strategic Partner, please call Edward VanHorn at (404) 256-0444.


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- 4 years ago
Cosmic Caffeine is your spiritual wake up call!
Listen as psychic medium, energy healers-Jamie, Mitchell & Evan take live callers and answer your questions about life, love, health, animal communication, spirit communication and everything in between! Sandy and Daniel will be working the chat room so call in now! Think of us as the Howard Stern of Psychic radio! We are straightforward and honest and the "real deal". We look forward to connecting for you!


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What does it take to start-up a start-up? How can you turn your skills in writing and research into a career as a freelancer?
Hear the CEO of Artist Deals and Laetare Consulting Lead, Katrina Boguski, share insights and tricks on how to launch the business of you.
When: September 23, 12-1:30pm
Where: Burnaby Campus, W.A.C. Bennett Library Room 7000
Katrina Boguski has an MA in Religious Studies from UBC. She has spent nearly a decade in sales for luxury industries such as yachting, fine art, and home electronic systems.
Katrina recently co-founded Artist Deals, which matches companies with musicians and their fans to provide consumer discounts.
This session is organized by the SFU Postdoctoral Fellows Association, the Office of Graduate Studies and Postdoctoral Fellow's APEX Professional Development Program and the Society for Canadian Women in Science and Technology.


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How can i update the BIOS of my HP compaq nc6000 noteBook?
What i have to do to upgrade my Bios of my laptop??
my laptop is older and now its model must be out of market so how can i get update for my laptop? is there any way to get it?? where can i find the other drivers for the hardware of my laptop??
the drivers are out dated so its really necessary for me to get some update for those hardware.
so some one please give me some reference of some sites where can i find those software updates.
My laptop's model is HP Compaq nc6000 its little bit older laptop so i can't find the software and bios update for the Laptop …so please help me to find out.


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One of my nutrition professors in graduate school, the esteemed Marion Nestle, once said that the best way she knows to get kids to eat is to teach them to cook. I couldn't agree more. Here you'll find tips, ideas, and inspiration for planning and buying groceries, prepping meals, and inviting your kids along for the ride.
Cooking & Shopping Smart
Cooking "How To"
- How to Clean Berries
- What is Tempeh and How to Cook it?
- How to Cut a Pineapple
- The Ultimate Guide to Slow Cooker Beans and Legumes
- How to Cook Spaghetti Squash in the Microwave
- How to Make Ice Cream without a Machine
- How to Cut Corn on the Cob
- How to Make and Freeze Smoothies
- How to Seed a Pomegranate
- How to Cut A Melon
- How to Store Natural Nut Butter
- How to Make Homemade Bread Crumbs
In the Kitchen with Kids
- 10 Ways to Get Kids Cooking
- 10 Ways to Get Kids Cooking Breakfast
- A Playbook for Getting Teens and Tweens to Cook This Summer
- 10 Cooking Skills Every Kid Should Know Before They Leave the Nest
- Keep a Clean Kitchen when Cooking with Kids
- 15 Favorite Cooking Gifts for Kids
- 7 Reasons to Teach Kids to Cook
- Take your Kids Berry Picking
- Best Kid's Kitchen Tools


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Hauntcast PM Maxwell Interview
Chris is convicted of 1st Degree Murder (murdering good taste that is) after conversing with the 3rd Degree of Terror's creator Warren Maxwell.
Hauntcast PM Kowal Interview
Chris has to call the Orkin Man to fumigate the dungeon after haunter Bob Kowal of the Attic Hatched Infestation yard haunt slithers in for a visit.
Hauntcast PM Rutherford Manor Interview
Winners of the Home Haunting Triple Crown, Thérèse & Hugh of the Rutherford Manor Haunt join your G/Host in the dungeon for a few adult bevies and to discuss discuss there award winning 2015 haunt season. [...]
Hauntcast PM Davis Interview
King and Queen of Halloween, Chris & Jeff Davis climb down from their Throne to talk to us peasants.
Hauntcast PM Denley Interview
Massholes Unite! Chris and John Denley pahk their cahs in the Hahvahd Yahd after poundin' some beehs and chatting about Bone Yahd Productions.
Hauntcast PM DarkRose Interview
Haunters for life, August & Pandora Rose are a thorn in Chris' side as the take over the dungeon.
Hauntcast PM Muncy Interview
Mark Muncy crashes the dungeon to converse with Chris about Halloween, haunting and the Hellview Cemetery.
Hauntcast PM Kleckner Interview
Jennifer Burns from Dorney Park adds a splash of color to the dungeon
Hauntcast PM Arnott Interview
Chris will crack open a few Canadian beers with Chris Arnott and shine some light on Dunnet's Dark Lair.
Interview with Chris Baker
An interview with Hauntcast G/Host Chris Baker of the Village Mire Yard Haunt.
Interview with Robert Beech
An interview with Robert Beech of Brandywine Cemetery
Interview with Noah Fentz
An interview with Noah Fentz of the Creepy House Next Door


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When a person is booked into a county jail in North Carolina, he or she does not expect fine meals or gentle treatment by deputies. But what that individual and his or her family have a right to expect is that the individual will at least be safe.
In too many instances, that bare minimum is not being met. Fifty-one county jail inmates in the past five years have died in those jails after being left unsupervised for longer than state regulations allow. In some cases, there have been financial settlements with families; in others, investigations. But a report by The News & Observer's Dan Kane and David Raynor demands urgent and emphatic action from the state Department of Public Safety, the governor and county boards of commissioners. The state Sheriffs Association also should take a significant role.
Because this must stop.
Some people can be brought to jail and left alone. They may be habitual offenders used to the routine, or people with lawyers they know are going to get them out, or perhaps people who have been wrongfully accused and are confident they'll soon be exiting the custody of the county.
But it's well known that jails often handle people with drug addictions or mental illness whose behavior is erratic. They also include in their inmate population people who have a history of doing harm to themselves, suffer from depression or are under intense drug therapy for chronic illnesses such as diabetes. A host of serious medical conditions are found in jails, but, because of the condition of inmates in terms of their ability to communicate, often go undetected.
Consider the case of Emily Jean Call, arrested in April of 2012 for missing a court date. She told officers she was high on drugs and wanted to kill herself, and in fact had cut her wrist just two weeks before her arrest.
She told medical staff that she was suffering and feared a nervous breakdown. State regulations showed the 32-year-old mother of two should have been checked on four times an hour. But Call went unwatched for more than an hour, got into a bathroom and used a sheet slung over a water pipe to hang herself.
There are too many other horrific stories. A diabetic who died because he wasn't checked for medical problems. A Durham inmate who hanged himself after being left alone for nearly six hours.
Some 38 jails, running the gamut from urban to rural, had deaths of unsupervised inmates.
The series clearly showed a rate of suicide as a percentage of jail deaths that was far too high; it showed inadequate medical care; it showed inconsistent follow-up in terms of investigations of jail deaths; it showed families in anguish for months or years after the deaths of loved ones in jails because they couldn't get answers.
Clearly, staffing is a problem. Jailers and deputies have long been underpaid, and county budgets have been stretched to the point where jails are woefully understaffed. To meet the supervisory needs is expensive. More expensive is providing psychiatric care that's increasingly a necessity in county jails that house people who would be more appropriately cared for in a mental health facility – but counties have too few of those as well.
Gov. Roy Cooper, who was familiar with the criminal justice system and its problems as few have been owing to his tenure as attorney general, clearly has to lead the way to address this life-and-death issue. Lawmakers should also work with the governor to find solutions, which in part are going to mean more funding for county jails, even if that funding must come from the state.
This has been a chronic problem. But the need for a solution is acute.


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Frequent flyers with British Airways will soon be able to cash in their air miles for lessons on how to survive plane crashes.
The airline is offering members of its Executive Club places in its new four-hour air safety course from next year for roughly the same price return flight from London to Rome -- about $195, The Independent reported Monday.
Andy Clubb, who is running the course, said, "It makes passengers safer when traveling by giving additional skills and information, it dispels all those internet theories about the brace position, and it just gives people so much more confidence in flying."
The course aims to teach people techniques that will increase their chance of surviving an air disaster and covers topics such as releasing the seat belt and locating life preservers. Participants will also have the chance to practice an emergency evacuation of an airplane using escape slides.
As well as improving their own chances of survival it is thought people who complete the course may also be able to help save the lives of other passengers.
"With other passengers around them reacting in a positive manner to the instructions being given by the crew, the few passengers that might have frozen might follow those who demonstrate that they know what they are doing," Clubb explained.


text: It's Truly a reality that one of the finest Nigerian R&B Pop Singer, Miebaka Asabuja. Mi2 The same Girl, Short Aboki crooner is back with his new hit Single Video-titled, IYAWO-MI, under the stables of G-Asabuja stimulation and Hypodrum ent. Music is Food to the Soul! Appreciate this visual the video was coordinated by ADASA COOKEY.


text: Ok I had the most intense episode yet... was sucking on a pen in a vain attempt to provide a placebo effect but wasnt working so i decided to use an older nicorette inhaler (the little white plastic pretend cigarette tube) but without the nicotine as an aid to get the crave away...there was an empty cartridge in it which i threw out and then rinsed through the inhaler...anyway long story short took a few sucks on this and felt better...anyway now am left feeling really guilty as was going cold turkey and am worried there was a tiny trace of nicotine left in the tube and i'm gonna end up worse off for it :eek::eek:...whats wrong with me??? lol am i being ridiculous??? Its totally passed now and i feel calm...i really hope its my breathing thats done that!...god somebody talk me down lol:o


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Envy Web + Design offers a range of website services, starting from the simplest of websites through to complex custom developments.
No matter what sort of website you are after, we can help. Whether it be static, dynamic, ecommerce or custom development. We have extensive knowledge in software development for web in a range of commercial industries.
Envy Design offers WordPress implementations for customers; we recommend WordPress as a great starting point for new to web customers - its usability and functionality makes WordPress very accessible to beginners. With a large range of Plugins and Themes, a high-quality website can be setup very quickly.
Dreaming of something new? Custom software refers to software that is specially developed for a specific organization or user, this can be applied to anything from a new idea to simply applying custom code to your particular business model.
Put simply, Search Engine Optimization (SEO) is about making your website easier to find in search engines (such as Google and Bing). When done properly, SEO increases your website's visibility and ensures you obtain higher rankings in natural search engine results.
We can help you with SEO on a new website build, or can review and improve the SEO on an existing website.
Social Media is a crucial part of your company's marketing toolbox.
Social platforms such as Facebook, Instagram, Twitter and Pinterest are some of the most widely used websites and apps today. This makes them invaluable for your business because your customers are on there - you just need to find ways to reach and engage with them.
We can help you set up social channels, create content and even manage social pages for you.
Professional Website design and Implementation, custom layouts, mobile design and more..
We offer Custom software services. Something unique, one of a kind - you've come to the right place
All new websites include entry level SEO, we also offer advanced SEO services for those wanting to enter the market competitively & remain competitive.
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text: I need to meet new friends to socialise with in and around paphos. I m a 46 year old lady ,young minded, seeking people to have coffee, go for drinks, dancing, etc. I dont have much free time and have decided i need to take action now as most of my friends have returned to the UK and I find myself twiddling my thumbs ........there is only so many times you can walk the dog!!! Please get in touch.


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The teenage years are a time when rules seem made to be broken… when the need for individuality is at its height, and when the desire for relevancy is strong.
And it is in these years that your repertoire choices for teen students are crucial.
A correctly-selected piano piece that includes opportunities for improvisation will inspire your students to practice with intensity. Using self-expression as a motivator, you can then hone in on the specific pedagogical concepts your teens need to progress as pianists.
But where do you find inspiring teen repertoire with opportunities for improvisation?
Enter With Celtic Courage. The 7 thrilling, celtic-themed piano pieces in this book will strengthen your students' comfort levels in 6/8 time while giving them measures of opportunity to make creative melodic decisions. With simple left-hand accompaniments, repeating patterns, accessible key signatures, and predictable formats, these pieces will encourage your teen piano students to escape into improvisation and make each piece their own.
Do your teens have the courage to break free from the page? With this book they'll discover their inner creative musicians that have been waiting for a moment to shine.
Check out a flip-through preview and listen to audio samples from this book here.
If you're interested in bringing the excitement of PianoBookClub to your studio, become a subscriber today.


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Lamar State College nursing transfer
To request course information, please complete this form. You may receive information from just one program, or several. Before making decisions about your future, compare programs carefully.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
To request course information, please complete this form. Before making decisions about your future, compare programs carefully.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
To request course information, please complete this form.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Learn about Lamar State College nursing transfer, registering for required degree courses, and taking free tests online. You can enter nursing with either an associates degree or BSN. As a licensed vocational nurse (LVN), you may provide patient care under the supervision of a registered nurse (RN). If you complete the nursing transfer process, for example, there are a variety of nursing concentrations that may appeal to you, such as hospital administration, nursing management, or occupational rehabilitation. Check with the nursing department for an updated schedule of classes, registration deadlines, and a list of nursing transfer requirements. Due to advances in medical systems, there is a growing skill-shortage of trained nursing staff, and of medical personnel in general. Please use the form above to request admissions info for Lamar State College.
To become a Registered Nurse (RN), you will be required to take courses in medical terminology, patient care and life sciences. Although associate degree programs provide students with adequate nursing transfer training, a bachelor's degree provides greater clinical exposure and a stronger general education. A 4-year BSN program allows students to study specialized areas of nursing, including pediatrics, geriatrics and mental health nursing. An RN has to cope with more responsibility, and must oversee the work of LPNs and CNAs under their supervision. Nursing job openings are projected to grow 16 percent over the coming decade, much faster than the average for all occupations. Finally, the average salary for nurses with an associates degree was $43,700 in 2015, while nurses with a bachelors degree earned $67,490 per year.
Certification requirements include board certification by the American Nurses Credentialing Center (ANCC) and the American Academy of Nurse Practitioners (AANP). The license period varies by individual state, but is usually valid for either two or three years, at which time you'll need to renew. Registered nurses (RNs) are not required to be certified in a particular specialty by state law. For example, it isn't necessary to be a Certified Medical-Surgical Registered Nurse (CMSRN) to work on a hospital Medical-Surgical (MedSurg) floor, and most MedSurg nurses are not CMSRNs. To keep your license current, you must take continuing education courses, and renew your license every few years.
RN II Labor & Delivery (Part Time - Evening Shift)
Sutter Health
Graduate of an accredited school of nursing. Coordinates professional nursing care within the Labor and Delivery unit..
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Associates Degree in Nursing. Come join the Critical Care Nursing Team at The Medical Center of Plano, a MAGNET facility. Registered Nurse Premium Pay!
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Mayo Clinic
The ANA Nursing. Baccalaureate Degree in Nursing (BN) from an accredited nursing program preferred. Associate's degree or diploma in Nursing..
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Under direct supervision of the provider and nursing leadership, performs a variety of administrative and clinical tasks to assist in the quality and..
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Bachelor's degree from an accredited college or university with a concentration in early childhood education, psychology, nursing or related field, plus one (1)..
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Tailored Healthcare Staffing
Graduate from an accredited school of Nursing, BSN preferred. We are one of the nation's fastest-growing travel nursing agencies, for good reason.
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Department of Health Programs
In addition to administering Medicare and Medicaid, which together provide health insurance to one in four Americans, HHS also oversees the National Institutes of Health, the Food and Drug Administration, and the Centers for Disease Control. The Secretary of Health and Human Services oversees a budget of approximately $700 billion and approximately 65,000 employees. The Department's programs are administered by 11 operating divisions, including 8 agencies in the U.S. Public Health Service and 3 human services agencies.
Online Tests - Free Practice!This section offers practice tests in a variety of subject areas. Each of the following multiple-choice tests has 10 questions to work on. No sign-up is required, just straight to the test.
Other colleges near Orange, Texas:Take a few moments to browse other colleges and universities near Orange. It's a good idea to compare all schools in your target area, as well as consider taking some of your classes online. By continuing your education, you can improve your salary prospects or train for a more interesting position. Financial aid deadlines are typically set well in advance of regular admission dates, so be sure to apply early. You may request free information from several different schools below, without making a commitment.
|College Guide
|In-state Tuition
|Out-of-state Tuition
|Student Body Size
|Request Info
|Lamar State College Orange
Orange, TX
|$ (low)
|Program Info
|Southwestern Adventist University
Keene, TX
|Program Info
|University of Texas at Brownsville
Brownsville, TX
|$ (low)
|Program Info
|University of Houston Clear Lake
Houston, TX
|$ (low)
|Program Info
|UT Permian Basin
Odessa, TX
|$ (low)
|Program Info
|TSTC Waco
Waco, TX
|$ (low)
|Program Info
|Del Mar College
Corpus Christi, TX
|$ (low)
|$ (low)
|Program Info
|Northeast Texas Community College
Mount Pleasant, TX
|$ (low)
|$ (low)
|Program Info
|East Texas Baptist University
Marshall, TX
|Program Info
|Tyler Junior College
Tyler, TX
|$ (low)
|$ (low)
|Program Info
|Richland College
Dallas, TX
|$ (low)
|$ (low)
|very large
|Program Info
|University of Dallas
Irving, TX
|Program Info
Nursing & Medical Job ListingsHealthcare jobs such as Registered Nurses, LPN's, LVN's and related Medical Technicians provide over 15 million jobs, and ten of the 20 fastest growing occupations are healthcare-related. Most healthcare workers have careers such as nursing transfer, health technologists and technicians, medical records, billing and coding, diagnostic medical sonographers, radiologic technologists, and dental hygienists. As people age they have more medical problems, and hospitals will require more staff. Wages vary by the employer and area of the county. Aside from their salary, most medical jobs include excellent benefits, as well as retirement plans.
|Job listings below are updated hourly:
|Starting Salary
(up to)
|10 Year Salary
(up to)
|Dental Assistants
|EMT, Paramedics
|Fitness Trainers
|Licensed Vocational Nurses (LVN)
|Massage Therapists
|Medical Assistants
|Medical Lab Technicians
|Mental Health Jobs
|Nurse Aides
|Occupational Therapist Assistants
|Occupational Therapists
|Pharmacy Tech
|Physical Therapist Assistants
|Public Health
|Radiologic Technicians
|Registered Nurses (RN)
|Respiratory Therapy Technicians
|Surgical Technologists
|Veterinary Assistants
Lamar State College nursing transferApply to several colleges and universities simultaneously, and if you have the grades and test scores, give yourself a fighting chance to get into a top-rated program by doing something outstanding in high school or community college. It isn't as hard as you might think to get an article written in your local newspaper. An advanced degree will stick with you for a long time, so apply yourself and work hard for a few years, graduating from the best school that you can get into.
Lamar State College nursing transfer
410 Front St
Orange, TX 77630
410 Front St
Orange, TX 77630


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Memory Park (RY Open event)
Tuesday, 24 October 2017 from 3:00 pm to 7:00 pm (Argentina Standard Time Argentina (Buenos Aires) Time)
Event Details
Like most of the countries from Latin America, Argentina had a very dark and violent dictatorship during the 60s and 70s. We recovered democracy in 1983, but there are lots of wounds to heal, lots of events to review.
Fernando, a lawyer and tour guide, will tell us about what happened during those time in Argentina. We'll be in the Memory Park, a park the government created a space of reflection for those difficult times.
How we are getting there: we are leaving from Aspen building to take a public bus. Expect a 40 - 60 min ride.
Location: Memory Park > > https://goo.gl/maps/R7xk1h92Qck
What to bring: Sunscreen, as it will outdoors. Jacket cause it will be next to the river and it can get windy. Will be walking in the park, so it's not adviced to bring heavy backpacks.
Food & Drinks: We'll give you a water bottle and a snack, but feel free to bring more.
Point of contact: Julieta Gonzalez | Slack: @juli.gonzalez
Note: This is a weather-dependent event. In case of rain forecast, we'll move the date.
When & Where
Thames 2313
Buenos Aires
Tuesday, 24 October 2017 from 3:00 pm to 7:00 pm (Argentina Standard Time Argentina (Buenos Aires) Time)
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