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Final Sale
Drew Chambray Trouser Pants
Sorry, this product is sold out online!
Sold Out Online:
Chambray Blue
Chambray Blue
Our modern Drew fit sits low on the waist with a straight hip and thigh, and an 8.5" rise.
- Online Exclusive
- Mid-weight chambray
- 2-button waist with inner button and zip fly, belt loops
- Pleated slash front pockets, besom back pockets
- 33" Inseam
- 100% Cotton
- Machine wash. Tumble dry.
- Imported
Item# 8374666
Okay, but not for me. I'm 5 ' 11 and they were too short. Quality was low as well. April 18, 2014
Lightweight pant Although these pants are a nice trouser fit and look like denim because of the color, the material is way too thin and lightweight. As a result they are very clingy from static in an unflattering way. April 18, 2014
Classy but not too dressy Great look and feel. Pretty long in the leg so I will have to get them altered but it's exactly the look I was going for. Dressed up but not too dressy. April 16, 2014
Very flattering Love the look! Great from the office to evening drinks paired with a short blazer or striped top. March 13, 2014
Perfect pants! These are some really nice pants. They do run a little small in the thigh area otherwise they are really nice and good quality! March 1, 2014
Love them! So glad they came out with chambray in Drew! The fit is perfect, but you all must know, although the description doesn't say anything about the legs, they are flare! You can't go wring with these, they look great with my limited patent navy shoes - bring back your shoes! February 28, 2014
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State plan targets skyrocketing rate of Alzheimer's
Sundsmo said the cuts would be "devastating" to many families caring for relatives with Alzheimer's disease.
"We're certainly open to creative solutions," she said. "Anything that would save these programs is better than nothing."
In the long term, the state also needs to resume funding research into the disease, said Sundsmo, who serves as program director at one of the 10 California Alzheimer's Disease Centers.
In 1985, the state spent nearly $91 million on the network of centers, which drew another $545 million in federal and private grants. In 2009, the state eliminated research funding, which could threaten continued federal funding.
The state plan emphasizes the need to provide enough caretaker training and support services, as well as better coordination between various programs, to help families care for their relatives at home for as long as possible.
"If you can help the family to keep their relative at home, which is what they want, you save money on nursing home stays, hospitalizations and visits to the emergency room," said Debra Cherry, executive vice president of the California Southland chapter of the Alzheimer's Association.

subset: commoncrawl


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William GrimesSacco and Vanzetti, Bruce Watson's spirited history of the affair, does a great service in rescuing fact from the haze of legend and disentangling Sacco and Vanzetti from the symbols they all too quickly became. It restores immediacy to a wretched series of events that first need to be understood on their own terms.
—The New York Times


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text:
Francis Scott Key
The Star-Spangled Banner Poem by Francis Scott Key
O! say can you see, by the dawn's early light,
What so proudly we hail'd at the twilight's last gleaming,
Whose broad stripes and bright stars through the perilous fight,
O'er the ramparts we watch'd, were so gallantly streaming?
And the rockets' red glare, the bombs bursting in air,
Gave proof through the night that our flag was still there -
O! say, does that star-spangled banner yet wave
O'er the land of the free, and the home of the brave?
On the shore, dimly seen through the mists of the deep,
Where the foe's haughty host in dread silence reposes,
What is that which the breeze o'er the towering steep,
As it fitfully blows, half conceals, half discloses?
Now it catches the gleam of the morning's first beam,
In full glory reflected now shines on the stream -
'Tis the star-spangled banner, O! long may it wave
O'er the land of the free, and the home of the brave.
And where is that band who so vauntingly swore
That the havock of war and the battle's confusion
A home and a country should leave us no more?
Their blood has wash'd out their foul foot-steps' pollution,
No refuge could save the hireling and slave,
From the terror of flight or the gloom of the grave;
And the star-spangled banner in triumph doth wave
O'er the land of the free, and the home of the brave.
O! thus be it ever when freemen shall stand
Between their lov'd home, and the war's desolation,
Blest with vict'ry and peace, may the heav'n-rescued land
Praise the power that hath made and preserv'd us a nation!
Then conquer we must, when our cause it is just,
And this be our motto - 'In God is our trust!'
And the star-spangled banner in triumph shall wave
O'er the land of the free, and the home of the brave.
Francis Scott Key's Other Poems
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Comments about this poem (The Star-Spangled Banner by Francis Scott Key )
Michael Walker (1/27/2015 8:44:00 PM)
I like this poem, which starts with a question, then adds another one (lines 7,8) . It is very patriotic without being jingoistic. I really like Whitney Houston singing 'The Star-Spangled Banner.' (Report) Reply
* Sunprincess * (6/4/2014 4:35:00 PM)
.......truly this is a great poem..... and one of my favourites....a pleasure to read this write again... (Report) Reply
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text:
Best Hydroponic Tree?
I'm sorry for being new to this but I was thinking about trying to grow a hydroponic tree. Indoors.
It would be under a 250W or 400W metal halide, probably 6000k. I was hoping for an evergreen species as it will be grown purely for aesthetic reasons. If somebody would be kind enough to help me with a few questions I would really appreciate it.
(a) Do I stand any chance at all?
(b) What species of tree would I stand the best chance with? (Would a mangrove be cheating? Or how about a willow?)
(c) What do you do about algae in the illuminated, neutrient rich water? As I said, this is all for aesthetic reasons.
(d) Any special tips for the species that you suggest?
Thank you in advance and best wishes,
That's a major undertaking. I've seen a banana tree grown hydroponically, but I think they just did it to say they could.
I think you'll want to grow a small tree with a shallow canopy. with only a 400w light, the bulk of that light will cover roughly a 3'x3' area and won't provide an extremely deep height of light (from the top leaves to the bottom)
As far as the algae goes, if you run some H2O2 through it periodically, that will do a good job of killing off the algae and cleaning up the appearance.


text:
WASHINGTON (AP) — Texas Rep. Pete Sessions says he's dropping bid for House majority leader.
Seattle police corral goats running through neighborhood
SEATTLE (AP) — Seattle police got their goats, corralling a group of 10 that had managed to get loose from a yard in the city's Beacon Hill neighborhood. Full Story
(Matt Dunham/AP)
Russian military TV station offers job to Jeremy Clarkson
MOSCOW (AP) — A television station owned by the Russian defense ministry is offering a job to former "Top Gear" host Jeremy Clarkson. Full Story
Zayn Malik quits One Direction; band to continue with four
Fame apparently became too much for Zayn Malik, who announced he is leaving the band after five years.


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Properties in Wall Meadow, Worcester, Worcestershire between £130,000 and £140,000
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£135,000 3 Bedrooms Fir Way, Worcester, Worcester WR4
A three bedroom semi-detached property, situated in this residential location. Offering entrance hall through to lounge, breakfast kitchen with deep storage cupboard and sliding patio doors onto rear garden . To the first floor are three good sized bedroo
£140,000 3 Bedrooms Colesborne Close, Worcester
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IRELAND The Show delivered on its promise to bring World Irish Dancing Champions to the stage with innovative choreography, renowned musicians and Las Vegas 'show' style costumes. Six of today's finest Irish dancers - Owen Barrington, Sinead Fallon, Stewart McWhinnie, Ciara Sexton, Ashley Smith and Ethan Walker - made an immediate connection with the audience during the opening number, and it didn't stop there.
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Fancy Lace Dress
Anna Sui All Falls into Lace Dress$374.99Price: $374.99
The evening is better than you ever couldve dreamed! You chat and mingle, fluttering about in this white lace dress by Anna Sui. It only makes sense to choose this V-neck design for an elegant affair - its scalloped black lace and floral-patterned ribbons showcase your poise effortlessly!
Labyrinthine Lace Dress in Coral$159.99Price: $159.99
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Lost in Lace Dress$59.99Price: $59.99
Youre happy to take a detour when it means you can show off this mint dress! Swathed in a white lace overlay that's patterned with flowers and stripes, this pleated frock pairs dynamic flair with a classic silhouette, leaving you dreaming of more ways of being seen.
Put on a Happy Lace Dress$79.99 $55.99Price: $79.99 $55.99 30% off!
You spread sunshine everywhere you go in this delightful dress! In hues of black and shimmering champagne, a floral lace motif is swathed in a layer of delicate netting on this pretty A-line. Boasting an illusion sweetheart neckline and back keyhole accent, this fetching frock always puts a smile on ...


text: College of Science http://hdl.handle.net/10197/1797 2015-03-29T09:25:06Z Developing Skills for Social and Emotional Wellbeing http://hdl.handle.net/10197/6432 Developing Skills for Social and Emotional Wellbeing Slovak, Petr; Wadely, Greg; Coyle, David; et al. Positive social and emotional well-being are essential for peoples' general health and quality of life. This workshop will bring together an inter-disciplinary community of well-being researchers, designers and practitioners to explore how digital technology can increase well-being by enabling users to develop new skills, build on existing personal strengths or social support, and promote self-efficacy more generally. We will jointly reach a better understanding of the opportunities that technology can bring for skills development across a broad range of contexts. Our aim is to consider how digital technology can support well-being skills for the general public and also for specific, at-need groups including the care givers of people coping with irreversible loss of mental or physical capacity and psycho-education for people experiencing mental health difficulties ACM Conference on Human Factors in Computing Systems, Seoul, Korea, 18-23 April, 2015 2015-04-01T00:00:00Z Integration of multiple network views in Wikipedia http://hdl.handle.net/10197/6416 Integration of multiple network views in Wikipedia Wu, Guangyu; Cunningham, Pádraig One of the challenges in network data analysis is the determination of the mostinformative perspective on the network to use in analysis. This is particularlyan issue when the network is dynamic and is defined by events that occur overtime. We present an example of such a scenario in the analysis of edit networks in Wikipedia the networks of editors interacting on Wikipedia pages. We proposethe prediction of article quality as a task that allows us to quantify the informativenessof alternative network views. We present three fundamentally different viewson the data that attempt to capture structural and temporal aspects of the edit networks.We demonstrate that each view captures information that is unique to thatview and propose a strategy for integrating the different sources of information 2014-11-07T00:00:00Z Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance http://hdl.handle.net/10197/6414 Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance Rojo, Ana I.; McBean, Gethin J.; Cindric, Marina; et al. Neurodegenerative diseases are characterized by chronic microglial over-activation and oxidative stress. It is now beginning to be recognized that reactive oxygen species (ROS) produced by either microglia or the surrounding environment not only impact neurons but also modulate microglial activity. In this review, we first analyze the hallmarks of pro-inflammatory and anti-inflammatory phenotypes of microglia and their regulation by ROS. Then, we consider the production of reactive oxygen and nitrogen species by NADPH oxidases and nitric oxide synthases and the new findings that also indicate an essential role of glutathione (γ-glutamyl-l-cysteinylglycine) in redox homeostasis of microglia. The effect of oxidant modification of macromolecules on signaling is analyzed at the level of oxidized lipid by-products and sulfhydryl modification of microglial proteins. Redox signaling has a profound impact on two transcription factors that modulate microglial fate, nuclear factor kappa-light-chain-enhancer of activated B cells, and nuclear factor (erythroid-derived 2)-like 2, master regulators of the pro-inflammatory and antioxidant responses of microglia, respectively. The relevance of these proteins in the modulation of microglial activity and the interplay between them will be evaluated. Finally, the relevance of ROS in altering blood brain barrier permeability is discussed. Recent examples of the importance of these findings in the onset or progression of neurodegenerative diseases are also discussed. This review should provide a profound insight into the role of redox homeostasis in microglial activity and help in the identification of new promising targets to control neuroinflammation through redox control of the brain 2014-10-06T00:00:00Z Automatic Timeline Construction For Computer Forensics Purposes http://hdl.handle.net/10197/6394 Automatic Timeline Construction For Computer Forensics Purposes Chabot, Yoan; Bertaux, Aurélie; Nicolle, Christophe; Kechadi, Tahar To determine the circumstances of an incident, investigators need to reconstruct events that occurred in the past. The large amount of data spread across the crime scene makes this task very tedious and complex. In particular, the analysis of the reconstructed timeline, due to the huge quantity of events that occurred on a digital system, is almost impossible and leads to cognitive overload. Therefore, it becomes more and more necessary to develop automatic tools to help or even replace investigators in some parts of the investigation. This paper introduces a multi-layered architecture designed to assist the investigative team in the extraction of information left in the crime scene, the construction of the timeline representing the incident and the interpretation of this latter. IEEE Joint Intelligence and Security Informatics Conference (ISI-EISIC 2014), 24-26 September, the Hague, Netherlands 2014-09-01T00:00:00Z Empirical evidence for a diminished sense of agency in speech interfaces http://hdl.handle.net/10197/6358 Empirical evidence for a diminished sense of agency in speech interfaces Limerick, Hannah; Moore, James W.; Coyle, David While the technology underlying speech interfaces has improved in recent years, our understanding of the human side of speech interactions remains limited. This paper provides new insight on one important human aspect of speech interactions: the sense of agency - defined as the experience of controlling one's own actions and their outcomes. Two experiments are described. In each case a voice command is compared with keyboard input. Agency is measured using an implicit metric: intentional binding. In both experiments we find that participants' sense of agency is significantly reduced for voice commands as compared to keyboard input. This finding presents a fundamental challenge for the design of effective speech interfaces. We reflect on this finding and, based on current theory in HCI and cognitive neuroscience, offer possible explanations for the reduced sense of agency observed in speech interfaces. ACM Conference on Human Factors in Computing Systems, Seoul, South Korea, 18-23 April, 2015 2015-04-23T00:00:00Z Tumor necrosis factor-α potentiates long-term potentiation in the rat dentate gyrus after acute hypoxia http://hdl.handle.net/10197/6355 Tumor necrosis factor-α potentiates long-term potentiation in the rat dentate gyrus after acute hypoxia Wall, Audrey M.; Mukandala, Gatambwa; Greig, Nigel H.; O'Connor, J. J. An inadequate supply of oxygen in the brain may lead to an inflammatory response through neuronal and glial cells that can result in neuronal damage. Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine that is released during acute hypoxia and can have neurotoxic or neuroprotective effects in the brain. Both TNF-α and interleukin-1β (IL-1β) have been shown by a number of research groups to alter synaptic scaling and also to inhibit long-term potentiation (LTP) in the hippocampus when induced by specific high-frequency stimulation (HFS) protocols. This study examines the effects of TNF-α on synaptic transmission and plasticity in hippocampal slices after acute hypoxia using two HFS protocols. Field excitatory postsynaptic potentials were elicited in the medial perforant pathway of the dentate gyrus. Exogenous TNF-α (5 ng/ml) attenuated LTP induced by theta burst stimulation but had no effect on LTP induced by a more prolonged HFS. Pretreatment with lipopolysaccharide (100 ng/ml) or TNF-α but not IL-1β (4 ng/ml) prior to a 30-min hypoxic insult resulted in a significant enhancement of LTP post hypoxia when induced by the HFS. Anti-TNF, 3,6′-dithiothalidomide (a TNF-α synthesis inhibitor), and SB203580 (a p38 MAPK inhibitor) significantly reduced this effect. These results indicate an important modulatory role for elevated TNF-α levels on LTP in the hippocampus after an acute hypoxic event. 2015-01-12T00:00:00Z Microbial biotransformation of aryl sulfanylpentafluorides http://hdl.handle.net/10197/6342 Microbial biotransformation of aryl sulfanylpentafluorides Kavanagh, Emma; Winn, Michael; Nic Gabhann, Cliona; O'Connor, Neil K.; Beier, Petr; Murphy, Cormac D. We report, for the first time, the biotransformation of potential pollutants bearing the pentafluorosulfanyl (SF5-) functional group in a fungus and bacteria. Cunninghamella elegans transformed p-methoxy phenyl SF5 via demethylation; Pseudomonas knackmussii and P. pseudoalcaligenes KF707 transformed amino-, hydroxyamino- and diamino- substituted phenyl SF5, forming the N-acetylated derivatives as the main product. Cell-free extract of Streptomyces griseus transformed 4-amino-3-hydroxy-phenyl SF5 to the N-acetylated derivative in the presence of acetyl CoA, confirming that an N-acetyltransferase is responsible for the bacterial biotransformations. Approximately 25 % of drugs and 30 % of agrochemicals contain fluorine, and the trifluoromethyl group is a prominent feature of many of these since it improves lipophilicity and stability. The pentafluorosulfanyl substituent is seen as an improvement on the trifluoromethyl group and research efforts are underway to develop synthetic methods to incorporate this moiety into biologically active compounds. It is important to determine the potential environmental impact of these compounds, including the potential biotransformation reactions that may occur when they are exposed to microorganisms. 2014-01-01T00:00:00Z Characterisitics of Streptomyces griseus biofilms in continuous flow tubular reactors http://hdl.handle.net/10197/6341 Characterisitics of Streptomyces griseus biofilms in continuous flow tubular reactors Winn, Michael; Habimana, Olivier; Casey, Eoin; Murphy, Cormac D. The purpose of this study was to investigate the feasibility of cultivating the biotechnologically important bacterium Streptomyces griseus in single-species and mixed- species biofilms using a Tubular Biofilm Reactor (TBR). Streptomyces griseus biofilm development was found to be cyclical, starting with the initial adhesion and subsequent development of a visible biofilm after 24 hours growth, followed by the complete detachment of the biofilm as a single mass, and ending with the re-colonization of the tube. Fluorescence microscopy revealed that the filamentous structure of the biofilm was lost upon treatment with protease, but not DNase or metaperiodate, indicating that the extracellular polymeric substance is predominantly protein. When the biofilm was cultivated in conjunction with Bacillus amyloliquefaciens, no detachment was observed after 96 h, although once subjected to flow detachment occurred. Electron microscopy confirmed the presence of both bacteria in the biofilm and revealed a network of fimbriae-like structures that were much less apparent in single-species biofilm, and are likely to increase mechanical stability when developing in a TBR. This study presents the very first attempt in engineering Streptomyces griseus biofilms for continuous bioprocess applications. 2014-03-01T00:00:00Z Two-Weight Codes, Graphs and Orthogonal Arrays http://hdl.handle.net/10197/6304 Two-Weight Codes, Graphs and Orthogonal Arrays Byrne, Eimear; Sneyd, Alison We investigate properties of two-weight codes over finite Frobenius rings, giving constructions for the modular case. A δ-modular code [15] is characterized as having a generator matrix where each column g appears with multiplicity δ|gR×| for some δ ∈ Q. Generalizing [10] and [5], we show that the additive group of a two-weight code satisfying certain constraint equations (and in particular a modular code) has a strongly regular Cayley graph and derive existence conditions on its parameters. We provide a construction for an infinite family of modular two-weight codes arising from unions of submodules with pairwise trivial intersection. The corresponding strongly regular graphs are isomorphic to graphs from orthogonal arrays. 2015-01-01T00:00:00Z The use of alkaline earth oxides as pH modifiers for selective glycerol oxidation over supported Au catalysts http://hdl.handle.net/10197/6287 The use of alkaline earth oxides as pH modifiers for selective glycerol oxidation over supported Au catalysts Sullivan, James A.; Burnham, Sarah The activity and selectivity of an Au/TiO2 catalyst in a reaction mixture which has had its pH adjusted by the addition of NaOH (aq) is compared to that of the same catalyst in reaction mixtures whose pH was adjusted using suspensions of BaO and CaO. It was found that the suspensions acted as effective bases and reactions in their presence showed similar conversions to those where NaOH(aq) was used. The selectivities of the reactions were different in each case. In all cases dihydroxyacetone, glyceric acid, glycolic acid and formic acid was produced but more glyceric acid was produced when alkaline earth oxide suspensions were used (at the expense of glycolic and formic acid) than when NaOH(aq) was used. Given glycolic and formic acids are produced from oxidation of glyceric acid, it seems that glyceric acid is somewhat stabilized against further oxidation in the presence of the group II oxides. One explanation for this is the formation of glyceric acid hemicalcium salts (and analogous Ba2+ species) in solution. 2015-01-01T00:00:00Z Angular derivatives on bounded symmetric domains http://hdl.handle.net/10197/6286 Angular derivatives on bounded symmetric domains Mackey, Michael C.; Mellon, Pauline In this paper we generalise the classical Julia-Wolff-Carathéodory theorem to holomorphic functions defined on bounded symmetric domains. 2003-03-01T00:00:00Z The identity is isolated among composition operators http://hdl.handle.net/10197/6285 The identity is isolated among composition operators Chu, C.-H.; Hügli, R. V.; Mackey, Michael C. Let H∞(B) be the Banach algebra of bounded holomorphic functions on the open unit ball B of a Banach space. We show that the identity operator is an isolated point in the space of composition operators on H∞(B). This answers a conjecture of Aron, Galindo and Lindstrom. 2004-01-01T00:00:00Z A Schwarz lemma and composition operators http://hdl.handle.net/10197/6284 A Schwarz lemma and composition operators Mackey, Michael C.; Mellon, Pauline We give an alternative description of the Carathéodory pseudodistance on a domain D in an arbitrary complex Banach space. This gives a Schwarz lemma for holomorphic maps of the domain.We specialise to the case of a bounded symmetric domain and obtain some applications. In particular, we give the connected components of the space of composition operators with symbol in a bounded symmetric domain. This generalises results for the space of composition operators on H∞(Δ) in [12] and for H∞(B) , B the unit ball of a Hilbert space or commutative C*-algebra in [2]. 2004-04-01T00:00:00Z Homotopes of JB*-triples and a Russo—Dye Theorem http://hdl.handle.net/10197/6283 Homotopes of JB*-triples and a Russo—Dye Theorem Mackey, Michael C. In this note, we look at homotopes of Jordan triple structures and show that, following a renorming, an isotope of a JB*-triple is also a JB*-triple. We also provide a proof of the Russo—Dye theorem for JBW*-triples. 2009-01-01T00:00:00Z On the Second Parameter of an (m, p)-Isometry http://hdl.handle.net/10197/6282 On the Second Parameter of an (m, p)-Isometry Hoffmann, Philipp; Mackey, Michael C.; Ó Searcóid, Mícheál A bounded linear operator T on a Banach space X is called an (m, p)-isometry if it satisfies the equation TeX , for all TeX . In this paper we study the structure which underlies the second parameter of (m, p)-isometric operators. We concentrate on determining when an (m, p)-isometry is a (μ, q)-isometry for some pair (μ, q). We also extend the definition of (m, p)-isometry, to include p = ∞ and study basic properties of these (m, ∞)-isometries. 2011-01-01T00:00:00Z Persistent Shallow Background Microseismicity on Hekla Volcano, Iceland: A Potential Monitoring Tool http://hdl.handle.net/10197/6281 Persistent Shallow Background Microseismicity on Hekla Volcano, Iceland: A Potential Monitoring Tool Eibl, Eva P. S.; Bean, Christopher J.; Vogfjörð, Kristín; Braiden, Aoife Hekla is one of Iceland's most active volcanoes. Since 1970 it has erupted four times with a period of quiescence of 14 years since the last eruption. We detected persistent levels of background microseismicity with a temporary seismic network in autumn 2012. An amplitude based as well as an arrival-time based location method was applied to two populations of events and located them at shallow depths on the northern flank, close to the summit. This seismicity has not been identified previously by the permanent seismic network in Iceland as it is below its detection threshold. The detected events were either short, higher frequency events with distinct arrivals located beneath the summit on the northern flank of Hekla or longer, emergent, lower frequency events about 4 km northeast of the summit at 200¿400 m depth below the surface. Estimated moment magnitudes were MW = -1.1 to -0.1 and MW = -0.9 to -0.0 and local magnitudes ML = -0.5 to +0.3 and ML = -0.3 to +0.3, respectively. This seismicity does not show any correlation with gas output but is located at the steepest slopes of the edifice. Hence we suggest that the current shallow microseismicity at Hekla is structurally controlled. This offers a possible opportunity of using near summit microseismicity as a tool for monitoring emerging unrest at Hekla. Microseismicity rates will be very sensitive to small stress perturbations due to magma migration at depth. Currently in the absence of microseismicity monitoring, Hekla switches from apparently quiescent to fully eruptive on the order of only 1 h. 2014-12-01T00:00:00Z Local derivations on Jordan triples http://hdl.handle.net/10197/6265 Local derivations on Jordan triples Mackey, Michael C. R. V. Kadison (J. Algebra 130 (1990) 494–509) defined the notion of local derivation on an algebra and proved that every continuous local derivation on a von Neumann algebra is a derivation. We provide the analogous result in the setting of Jordan triples. 2013-03-01T00:00:00Z Potential seasonal calibration for palaeoenvironmental reconstruction using skeletal microstructures and strontium measurements from the cold-water coral Lophelia pertusa http://hdl.handle.net/10197/6259 Potential seasonal calibration for palaeoenvironmental reconstruction using skeletal microstructures and strontium measurements from the cold-water coral Lophelia pertusa Mouchi, Vincent; Crowley, Quentin G.; Jackson, Andrew L.; McDermott, Frank; et al. Lophelia pertusa is a colonial cold-water coral species with a wide spatial distribution in recent marine waters. Analysing the chemistry of its skeleton allows reconstruction of environmental parameter variations. While numerous studies have attempted to interpret such analyses, little information is available on the microstructures of Lophelia pertusa and their temporal constraints. This study introduces newly recognized microstructures in the coral wall following growth along the radial axis. The thicknesses of these 'micro-layers' are correlated with strontium concentrations and can be used to estimate seasonal growth rates of single polyps from the colony. We propose that each of these micro-layers represents a period of 1 month of mineralization and can locate two decreasing periods in growth rate during a year: one caused by limited food availability during winter months and one in autumn linked to gametogenesis. High-frequency study of strontium concentrations using this interpretation shows a lunar cycle. We demonstrate that while the micro-layers are present in all L. pertusa specimens from four locations in the Atlantic Ocean and the Mediterranean Sea, growth patterns reveal a complex organization that limits their visibility. Strontium fluctuations, however, appear to be a promising mechanism by which to establish a temporal calibration. 2014-11-01T00:00:00Z Demonstrating Social Error Recovery with AgentFactory http://hdl.handle.net/10197/6249 Demonstrating Social Error Recovery with AgentFactory O'Hare, G. M. P. (Greg M. P.); Collier, Rem; Ross, Robert Exception handling is a well established method of error recovery through the alteration of plans in situ . This method relies on recovery routines existing in advance, which - we argue - is simply shorthand for more detailed plan descriptions. However, in practice, agents rarely act alone in their environment - other agents may exist, and potentially provide help in times of need. We argue that social error recovery is a particular class of exception handling that allows agents to resolve erroneous situations that are beyond their direct control. In our opinion, agent oriented programming languages must directly provide agents with abilities like social error recovery. Consequently, we introduce revisions to the AgentFactory framework, and more specifically, the programming language (AF-APL), which facilitate the rapid development of agents with in-built social error recovery. The use of these abilities are illustrated via an example of a social error recovery scenario for a mobile robot working as an office assistant. 3rd International Joint Conference on Autonomous Agents and Multi Agent Systems (AAMAS04), New York, USA, 19-23 July 2004 2004-07-01T00:00:00Z Mobile BDI Agents http://hdl.handle.net/10197/6229 Mobile BDI Agents Collier, Rem; Rooney, Colm; O'Donoghue, Ruadhan; O'Hare, G. M. P. (Greg M. P.) Much work has been done in the area of Mobile Agents. However, the majority of this research has emphasized "mobile" and largely ignored "agent". This paper attempts to rectify this through the presentation of research that combines the areas of Intentional Agents and Mobility, namely the construction of Mobile BDI Agents. 11th Irish Conference on Artificial Intelligence & Cognitive Science, Galway, Ireland, 23-25 August, 2000 2000-08-01T00:00:00Z An upper bound on Jacobsthal's function http://hdl.handle.net/10197/6186 An upper bound on Jacobsthal's function Costello, Fintan; Watts, Paul The function h(k) represents the smallest number m such that every sequence of m consecutive integers contains an integer coprime to the first k primes. We give a new computational method for calculating strong upper bounds on h(k). 2014-11-01T00:00:00Z Surprisingly rational: Probability theory plus noise explains biases in judgment http://hdl.handle.net/10197/6185 Surprisingly rational: Probability theory plus noise explains biases in judgment Costello, Fintan; Watts, Paul The systematic biases seen in people's probability judgments are typically taken as evidence that people do not use the rules of probability theory when reasoning about probability but instead use heuristics, which sometimes yield reasonable judgments and sometimes yield systematic biases. This view has had a major impact in economics, law, medicine, and other fields; indeed, the idea that people cannot reason with probabilities has become a truism. We present a simple alternative to this view, where people reason about probability according to probability theory but are subject to random variation or noise in the reasoning process. In this account the effect of noise is canceled for some probabilistic expressions. Analyzing data from 2 experiments, we find that, for these expressions, people's probability judgments are strikingly close to those required by probability theory. For other expressions, this account produces systematic deviations in probability estimates. These deviations explain 4 reliable biases in human probabilistic reasoning (conservatism, subadditivity, conjunction, and disjunction fallacies). These results suggest that people's probability judgments embody the rules of probability theory and that biases in those judgments are due to the effects of random noise 2014-07-01T00:00:00Z Different dispersions of group II catalysts over SBA 15 and MCM-41: Effects on transesterification reactivity http://hdl.handle.net/10197/6184 Different dispersions of group II catalysts over SBA 15 and MCM-41: Effects on transesterification reactivity Sullivan, James A.; Sherry, Linda Activities of CaO catalysts on SBA-15 and MCM-41 have been compared in transesterification and SBA-15 supported samples invariably more active than those on MCM-41. Increased activity is not due to diffusional effects (as measured using substrates of differing size) but rather to increased dispersion of CaO on SBA-15 (as measured using NOx TPD). The effect, i.e. increased reactivity of SBA-15 supported catalysts being related to increased dispersion, is also noted in supported BaO catalysts while supported MgCO3 catalysts show little variation in dispersion (or in reactivity) as a function of the support used. 2014-01-01T00:00:00Z High Resolution Time Of Arrival Estimation for OFDM-Based Transceivers http://hdl.handle.net/10197/6171 High Resolution Time Of Arrival Estimation for OFDM-Based Transceivers Makki, Ahmed; Siddig, Abubakr; Saad, Saad, Mohamed M.; Cavallaro, J. R.; Bleakley, Chris This letter presents a novel algorithm for Time Of Arrival (TOA) estimation for Orthogonal Frequency Division Multiplexing (OFDM) based transceivers. The algorithm processes the sampled baseband signal to obtain a high resolution estimate of the TOA of the OFDM symbol. In the first step, the algorithm obtains a sample resolution estimate of the TOA by finding the peak of the absolute value of the cross-correlation of the in-phase and quadrature received signals with the known transmitted symbol. In the second step, the algorithm refines this estimate to sub-sample resolution by estimating the phase delay of the received signal based on the gradient of a linear fit to the phase difference between the transmitted and received sub-carriers (in the frequency domain). The algorithm was applied to the Long Training Sequence (LTS) symbol of the IEEE Wireless Local Area Network (WLAN) 802.11g preamble. In real-world experiments, the algorithm was found to achieve a mean TOA estimation error of 49 cm in a low multi-path Line Of Sight (LOS) environment for ranges of 1-7 m. 2014-10-01T00:00:00Z Mechanisms of beneficial colonisation of barley by fungal root endophytes http://hdl.handle.net/10197/6169 Mechanisms of beneficial colonisation of barley by fungal root endophytes Murphy, Brian; Hodkinson, Trevor; Doohan, Fiona Pathogenic fungal infections of barley can lead to costly crop losses. However, not all fungal infections are detrimental, and some are even beneficial. Beneficial root infections often involve symbiotic endophytic fungi. Benefits to barley and other plants infected with endophytic root fungi include an increase in seed yield, enhanced resistance to pathogens and improved stress tolerance. Here, we examine the mechanisms and outcomes of fungal endophyte colonisation of barley roots and briefly discuss reported benefits for the host. The most important factors that determine the nature of the relationship are the specific combination of partner genotypes and developmental stage, and the ecological and environmental setting. The full potential of these organisms is still to be determined and further studies are urgently required to develop specific beneficial root-endophyte associations, or combination of them, that are tailored to barley cultivars for maximum impact in agriculture. 2013-01-01T00:00:00Z A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder http://hdl.handle.net/10197/6163 A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder Casey, Jillian; Magalhaes, Tiago; Conroy, Judith M.; Regan, Regina; Shah, Naisha; Shields, Denis C.; Green, Andrew; Ennis, Sean; et al. Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and fundamental deficits in social reciprocity. Despite some notable successes in neuropsychiatric genetics, overall, the high heritability of ASD (~90%) remains poorly explained by common genetic risk variants. However, recent studies suggest that rare genomic variation, in particular copy number variation, may account for a significant proportion of the genetic basis of ASD. We present a large scale analysis to identify candidate genes which may contain low-frequency recessive variation contributing to ASD while taking into account the potential contribution of population differences to the genetic heterogeneity of ASD. Our strategy, homozygous haplotype (HH) mapping, aims to detect homozygous segments of identical haplotype structure that are shared at a higher frequency amongst ASD patients compared to parental controls. The analysis was performed on 1,402 Autism Genome Project trios genotyped for 1 million single nucleotide polymorphisms (SNPs). We identified 25 known and 1,218 novel ASD candidate genes in the discovery analysis including CADM2, ABHD14A, CHRFAM7A, GRIK2, GRM3, EPHA3, FGF10, KCND2, PDZK1, IMMP2L and FOXP2. Furthermore, 10 of the previously reported ASD genes and 300 of the novel candidates identified in the discovery analysis were replicated in an independent sample of 1,182 trios. Our results demonstrate that regions of HH are significantly enriched for previously reported ASD candidate genes and the observed association is independent of gene size (odds ratio 2.10). Our findings highlight the applicability of HH mapping in complex disorders such as ASD and offer an alternative approach to the analysis of genome-wide association data. 2012-04-01T00:00:00Z Recessive mutations in MCM4/PRKDC cause a novel syndrome involving a primary immunodeficiency and a disorder of DNA repair http://hdl.handle.net/10197/6162 Recessive mutations in MCM4/PRKDC cause a novel syndrome involving a primary immunodeficiency and a disorder of DNA repair Casey, Jillian; Nobbs, Michael; McGettigan, Paul A.; Ennis, Sean; et al. Background: A study is presented of 10 children with a novel syndrome born to consanguineous parents from the Irish Traveller population. The syndrome is characterised by a natural killer (NK) cell deficiency, evidence of an atypical Fanconi's type DNA breakage disorder, and features of familial glucocorticoid deficiency (FGD). The NK cell deficiency probably accounts for the patients' recurrent viral illnesses. Molecular tests support a diagnosis of mosaic Fanconi's anaemia, but the patients do not present with any of the expected clinical features of the disorder. The symptomatic presentation of FGD was delayed in onset and may be a secondary phenotype. As all three phenotypes segregate together, the authors postulated that the NK cell deficiency, DNA repair disorder and FGD were caused by a single recessive genetic event.Methods: Single-nucleotide polymorphism homozygosity mapping and targeted next-generation sequencing of 10 patients and 16 unaffected relatives. Results: A locus for the syndrome was identified at 8p11.21-q11.22. Targeted resequencing of the candidate region revealed a homozygous mutation in MCM4/PRKDC in all 10 affected individuals. Consistent with the observed DNA breakage disorder, MCM4 and PRKDC are both involved in the ATM/ATR (ataxia-telangiectasia-mutated/ATM-Rad 3-related) DNA repair pathway, which is defective in patients with Fanconi's anaemia. Deficiency of PRKDC in mice has been shown to result in an abnormal NK cell physiology similar to that observed in these patients.Conclusion: Mutations in MCM4/PRKDC represent a novel cause of DNA breakage and NK cell deficiency. These findings suggest that clinicians should consider this disorder in patients with failure to thrive who develop pigmentation or who have recurrent infections. 2012-04-01T00:00:00Z Completely bounded norms of right module maps http://hdl.handle.net/10197/6158 Completely bounded norms of right module maps Levene, Rupert H.; Timoney, Richard M. It is well-known that if T is a Dm–Dn bimodule map on the m×n complex matrices, then T is a Schur multiplier and kTkcb = kTk. If n = 2 and T is merely assumed to be a right D2-module map, then we show that kTkcb = kTk. However, this property fails if m ≥ 2 and n ≥ 3. For m ≥ 2 and n = 3, 4 or n ≥ m2 we give examples of maps T attaining the supremum C(m, n) = sup{kTkcb : T a right Dn-module map on Mm,n with kTk ≤ 1}, we show that C(m, m2) = √ m and succeed in finding sharp results for C(m, n) in certain other cases. As a consequence, if H is an infinite-dimensional Hilbert space and D is a masa in B(H), then there is a bounded right D-module map on K(H) which is not completely bounded. 2012-03-01T00:00:00Z Singular solutions for second-order non-divergence type elliptic inequalities in punctured balls http://hdl.handle.net/10197/6149 Singular solutions for second-order non-divergence type elliptic inequalities in punctured balls Ghergu, Marius; Liskevich, Vitali; Sobol, Zeev We study the existence and non-existence of positive singular solutions of second-order non-divergence type elliptic inequalities of the form $\sum\limits_{i,j = 1}^N {a_{ij} (x)\frac{{\partial ^2 u}} {{\partial x_i \partial x_j }}} + \sum\limits_{i = 1}^N {b_i (x)\frac{{\partial u}} {{\partial x_i }} \geqslant K(x)u^p ,} - \infty < p - \infty , $ with measurable coefficients in a punctured ball B R \{0} of ℝ N , N ≥ 1. We prove the existence of a critical value p* which separates the existence region from the non-existence region. We show that in the critical case p = p*, the existence of a singular solution depends on the rate at which the coefficients (a i j ) and (b i ) stabilize at zero, and we provide some optimal conditions in this setting. 2014-07-24T00:00:00Z Performance Evaluation of a Natural Language Processing approach applied in White Collar crime investigation http://hdl.handle.net/10197/6137 Performance Evaluation of a Natural Language Processing approach applied in White Collar crime investigation van Banerveld, Maarten; Le-Khac, Nhien-An; Kechadi, Tahar In today's world we are confronted with increasing amounts of information every day coming from a large variety of sources. People and corporations are producing data on a large scale, and since the rise of the internet, e-mail and social media the amount of produced data has grown exponentially. From a law enforcement perspective we have to deal with these huge amounts of data when a criminal investigation is launched against an individual or company. Relevant questions need to be answered like who committed the crime, who were involved, what happened and on what time,who were communicating and about what? Not only the amount of available data to investigate has increased enormously, but also the complexity of this data has increased. When these communication patterns need to be combined with for instance a seized financial administration or corporate document shares a complex investigation problem arises. Recently, criminal investigators face a huge challenge when evidence of a crime needs to be found in the Big Data environment where they have to deal with large and complex datasets especially in financial and fraud investigations. To tackle this problem, a financial and fraud investigation unit of a European country has developed a new tool named LES that uses Natural Language Processing (NLP) techniques to help criminal investigators handle large amounts of textual information in a more efficient and faster way. In this paper, we present briefly this tool and we focus on the evaluation its performance in terms of the requirements of forensic investigation: speed, smarter and easier for investigators. In order to evaluate this LES tool, we use different performance metrics. We also show experimental results of our evaluation with large and complex datasets from real-world application. Future Data and Security Engineering, 1st International Conference on Future Data and Security Engineering 2014 (FDSE 2014), Springer Verlag LNCS, HoChiMinh City, Vietnam,19-21 November 2014 2014-09-01T00:00:00Z Breaking the limits of structural and mechanical imaging of the heterogeneous structure of coal macerals http://hdl.handle.net/10197/6136 Breaking the limits of structural and mechanical imaging of the heterogeneous structure of coal macerals Collins, Liam; Tselev, A.; Jesse, S.; Rodriguez, Brian J.; et al. The correlation between local mechanical (elasto-plastic) and structural (composition) properties of coal presents significant fundamental and practical interest for coal processing and for the development of rheological models of coal to coke transformations. Here, we explore the relationship between the local structural, chemical composition, and mechanical properties of coal using a combination of confocal micro-Raman imaging and band excitation atomic force acoustic microscopy for a bituminous coal. This allows high resolution imaging (10s of nm) of mechanical properties of the heterogeneous (banded) architecture of coal and correlating them to the optical gap, average crystallite size, the bond-bending disorder of sp2 aromatic double bonds, and the defect density. This methodology allows the structural and mechanical properties of coal components (lithotypes, microlithotypes, and macerals) to be understood, and related to local chemical structure, potentially allowing for knowledge-based modeling and optimization of coal utilization processes. 2014-10-09T00:00:00Z Norms of idempotent Schur multipliers http://hdl.handle.net/10197/6134 Norms of idempotent Schur multipliers Levene, Rupert H. Let D be a masa in B(H) where H is a separable Hilbert space. We find real numbers η0 < η1 < η2 < · · · < η6 so that for every bounded, normal D-bimodule map Φ on B(H), either kΦk > η6 or kΦk = ηk for some k ∈ {0, 1, 2, 3, 4, 5, 6}. When D is totally atomic, these maps are the idempotent Schur multipliers and we characterise those with norm ηk for 0 ≤ k ≤ 6. We also show that the Schur idempotents which keep only the diagonal and superdiagonal of an n × n matrix, or of an n×(n+ 1) matrix, both have norm 2 n+1 cot(π 2(n+1) ), and we consider the average norm of a random idempotent Schur multiplier as a function of dimension. Many of our arguments are framed in the combinatorial language of bipartite graphs. 2014-04-07T00:00:00Z Light influences how the fungal toxin deoxynivalenol affects plant cell death and defense responses http://hdl.handle.net/10197/6130 Light influences how the fungal toxin deoxynivalenol affects plant cell death and defense responses Ansari, Khairul I.; Doyle, Siamsa M.; Kacprzyk, Joanna; Arunachalam, Chanemouga Soundharam; McCabe, Paul F.; Doohan, Fiona; et al. The Fusarium mycotoxin deoxynivalenol (DON) can cause cell death in wheat (Triticum aestivum), but can also reduce the level of cell death caused by heat shock in Arabidopsis (Arabidopsis thaliana) cell cultures. We show that 10 μg mL−1 DON does not cause cell death in Arabidopsis cell cultures, and its ability to retard heat-induced cell death is light dependent. Under dark conditions, it actually promoted heat-induced cell death. Wheat cultivars differ in their ability to resist this toxin, and we investigated if the ability of wheat to mount defense responses was light dependent. We found no evidence that light affected the transcription of defense genes in DON-treated roots of seedlings of two wheat cultivars, namely cultivar CM82036 that is resistant to DON-induced bleaching of spikelet tissue and cultivar Remus that is not. However, DON treatment of roots led to genotype-dependent and light-enhanced defense transcript accumulation in coleoptiles. Wheat transcripts encoding a phenylalanine ammonia lyase (PAL) gene (previously associated with Fusarium resistance), non-expressor of pathogenesis-related genes-1 (NPR1) and a class III plant peroxidase (POX) were DON-upregulated in coleoptiles of wheat cultivar CM82036 but not of cultivar Remus, and DON-upregulation of these transcripts in cultivar CM82036 was light enhanced. Light and genotype-dependent differences in the DON/DON derivative content of coleoptiles were also observed. These results, coupled with previous findings regarding the effect of DON on plants, show that light either directly or indirectly influences the plant defense responses to DON. 2014-02-20T00:00:00Z Insights from the Fungus Fusarium oxysporum Point to High Affinity Glucose Transporters as Targets for Enhancing Ethanol Production from Lignocellulose http://hdl.handle.net/10197/6129 Insights from the Fungus Fusarium oxysporum Point to High Affinity Glucose Transporters as Targets for Enhancing Ethanol Production from Lignocellulose Ali, Shahin S.; Nugent, Brian; Mullins, Ewen; Doohan, Fiona Ethanol is the most-widely used biofuel in the world today. Lignocellulosic plant biomass derived from agricultural residue can be converted to ethanol via microbial bioprocessing. Fungi such as Fusarium oxysporum can simultaneously saccharify straw to sugars and ferment sugars to ethanol. But there are many bottlenecks that need to be overcome to increase the efficacy of microbial production of ethanol from straw, not least enhancement of the rate of fermentation of both hexose and pentose sugars. This research tested the hypothesis that the rate of sugar uptake by F. oxysporum would enhance the ethanol yields from lignocellulosic straw and that high affinity glucose transporters can enhance ethanol yields from this substrate. We characterized a novel hexose transporter (Hxt) from this fungus. The F. oxysporum Hxt represents a novel transporter with homology to yeast glucose signaling/transporter proteins Rgt2 and Snf3, but it lacks their C-terminal domain which is necessary for glucose signalling. Its expression level decreased with increasing glucose concentration in the medium and in a glucose uptake study the Km(glucose) was 0.9 mM, which indicated that the protein is a high affinity glucose transporter. Post-translational gene silencing or over expression of the Hxt in F. oxysporum directly affected the glucose and xylose transport capacity and ethanol yielded by F. oxysporum from straw, glucose and xylose. Thus we conclude that this Hxt has the capacity to transport both C5 and C6 sugars and to enhance ethanol yields from lignocellulosic material. This study has confirmed that high affinity glucose transporters are ideal candidates for improving ethanol yields from lignocellulose because their activity and level of expression is high in low glucose concentrations, which is very common during the process of consolidated processing. 2013-01-30T00:00:00Z The Fusarium Mycotoxin Deoxynivalenol Can Inhibit Plant Apoptosis-Like Programmed Cell Death http://hdl.handle.net/10197/6128 The Fusarium Mycotoxin Deoxynivalenol Can Inhibit Plant Apoptosis-Like Programmed Cell Death Diamond, Mark; Reape, Theresa J.; Rocha, Olga; Doyle, Siamsa M.; Kacprzyk, Joanna; Doohan, Fiona; McCabe, Paul F. The Fusarium genus of fungi is responsible for commercially devastating crop diseases and the contamination of cereals with harmful mycotoxins. Fusarium mycotoxins aid infection, establishment, and spread of the fungus within the host plant. We investigated the effects of the Fusarium mycotoxin deoxynivalenol (DON) on the viability of Arabidopsis cells. Although it is known to trigger apoptosis in animal cells, DON treatment at low concentrations surprisingly did not kill these cells. On the contrary, we found that DON inhibited apoptosis-like programmed cell death (PCD) in Arabidopsis cells subjected to abiotic stress treatment in a manner independent of mitochondrial cytochrome c release. This suggested that Fusarium may utilise mycotoxins to suppress plant apoptosis-like PCD. To test this, we infected Arabidopsis cells with a wild type and a DON-minus mutant strain of F. graminearum and found that only the DON producing strain could inhibit death induced by heat treatment. These results indicate that mycotoxins may be capable of disarming plant apoptosis-like PCD and thereby suggest a novel way that some fungi can influence plant cell fate. 2013-07-26T00:00:00Z Genome sequence of Ensifer adhaerens OV14 provides insights into its ability as a novel vector for the genetic transformation of plant genomes http://hdl.handle.net/10197/6127 Genome sequence of Ensifer adhaerens OV14 provides insights into its ability as a novel vector for the genetic transformation of plant genomes Rudder, Steven; Doohan, Fiona; Creevey, Christopher J.; Wendt, Toni; et al. Background: Recently it has been shown that Ensifer adhaerens can be used as a plant transformation technology, transferring genes into several plant genomes when equipped with a Ti plasmid. For this study, we have sequenced the genome of Ensifer adhaerens OV14 (OV14) and compared it with those of Agrobacterium tumefaciens C58 (C58) and Sinorhizobium meliloti 1021 (1021); the latter of which has also demonstrated a capacity to genetically transform crop genomes, albeit at significantly reduced frequencies. Results: The 7.7 Mb OV14 genome comprises two chromosomes and two plasmids. All protein coding regions in the OV14 genome were functionally grouped based on an eggNOG database. No genes homologous to the A. tumefaciens Ti plasmid vir genes appeared to be present in the OV14 genome. Unexpectedly, OV14 and 1021 were found to possess homologs to chromosomal based genes cited as essential to A. tumefaciens T-DNA transfer. Of significance, genes that are non-essential but exert a positive influence on virulence and the ability to genetically transform host genomes were identified in OV14 but were absent from the 1021 genome. Conclusions: This study reveals the presence of homologs to chromosomally based Agrobacterium genes that support T-DNA transfer within the genome of OV14 and other alphaproteobacteria. The sequencing and analysis of the OV14 genome increases our understanding of T-DNA transfer by non-Agrobacterium species and creates a platform for the continued improvement of Ensifer-mediated transformation (EMT). 2014-04-07T00:00:00Z Cognitively Adequate Topological Robot Localization and Mapping http://hdl.handle.net/10197/6126 Cognitively Adequate Topological Robot Localization and Mapping Corcoran, Padraig; Bertolotto, Michela; Leonard, John J. Simultaneous Localization and Mapping (SLAM) is a fundamental problem in the eld of robotics which concerns mapping an environment or space while simultaneously localizing within this map. Given that one of the major goals of robotics is to perform tasks commonly performed by humans, we argue that SLAM methods should be cognitively adequate; that is, they should model the same properties of a space as the human cognition models. Topological properties are considered the most fundamental of those modlelled by the human cognition. Therefore in order to achieve cognitive adequacy such properties must be modelled explicitly. Research in the domain of spatial cognition has demonstrated that the topological properties modelled by the human cognition can be quanti ed using the Egenhofer Nine-Intersection Model (9-IM). In this work we propose a conceptual SLAM method which models the same properties as the 9-IM. Relative to existing topological SLAM methods, which model a single topological property of connectivity between locations, this method achieves a stronger degree of cognitive adequacy. 22nd ACM SIGSPATIAL International Workshop on Indoor Spatial Awareness (ISA), Dallas, Texas, USA, 4-7 November, 2014 2014-11-01T00:00:00Z Automated Highway Tag Assessment of OpenStreetMap Road Networks http://hdl.handle.net/10197/6125 Automated Highway Tag Assessment of OpenStreetMap Road Networks Jilani, Musfira; Corcoran, Padraig; Bertolotto, Michela OpenStreetMap (OSM) has been demonstrated to be a valuable source of spatial data in the context of many applications. However concerns still exist regarding the quality of such data and this has limited the proliferation of its use. Consequently much research has been invested in the development of methods for assessing and/or improving the quality of OSM data. However most of these methods require ground-truth data, which, in many cases, may not be available. In this paper we present a novel solution for OSM data quality assessment that does not require ground-truth data. We consider the semantic accuracy of OSM street network data, and in particular, the associated semantic class (road class) information. A machine learning model is proposed that learns the geometrical and topological characteristics of di erent semantic classes of streets. This model is subsequently used to accurately determine if a street has been assigned a correct/incorrect semantic class. 22nd ACM SIGSPATIAL (International Conference on Advances in Geographic Information Systems), Dallas, Texas, USA, 4-7 November, 2014 2014-11-01T00:00:00Z High viscosity environments: an unexpected route to obtain true atomic resolution with atomic force microscopy http://hdl.handle.net/10197/6122 High viscosity environments: an unexpected route to obtain true atomic resolution with atomic force microscopy Weber, Stefan A. L.; Kilpatrick, J. I.; Brosnan, Timothy M.; Jarvis, Suzi; Rodriguez, Brian J. Atomic force microscopy (AFM) is widely used in liquid environments, where true atomic resolution at the solid–liquid interface can now be routinely achieved. It is generally expected that AFM operation in more viscous environments results in an increased noise contribution from the thermal motion of the cantilever, thereby reducing the signal-to-noise ratio (SNR). Thus, viscous fluids such as ionic and organic liquids have been generally avoided for high-resolution AFM studies despite their relevance to, e.g. energy applications. Here, we investigate the thermal noise limitations of dynamic AFM operation in both low and high viscosity environments theoretically, deriving expressions for the amplitude, phase and frequency noise resulting from the thermal motion of the cantilever, thereby defining the performance limits of amplitude modulation, phase modulation and frequency modulation AFM. We show that the assumption of a reduced SNR in viscous environments is not inherent to the technique and demonstrate that SNR values comparable to ultra-high vacuum systems can be obtained in high viscosity environments under certain conditions. Finally, we have obtained true atomic resolution images of highly ordered pyrolytic graphite and mica surfaces, thus revealing the potential of high-resolution imaging in high viscosity environments. 2014-04-09T00:00:00Z Propagation of microseisms from the deep ocean to land http://hdl.handle.net/10197/6119 Propagation of microseisms from the deep ocean to land Ying, Yingzi; Bean, Christopher J.; Bromirski, Peter D. Ocean-generated microseisms are faint Earth vibrations that result from pressure fluctuations at the sea floor generated by the interaction between ocean surface gravity waves, and are continuously recorded as low frequency seismic noise. Here we investigate microseism propagation away from deep-ocean source regions using the spectral element method for an oceanic model that contains realistic northeast Atlantic Ocean irregular-layered structure composed of water, sediment, and upper crust. It also includes structural heterogeneities and continental slope and shelf bathymetry. Numerical simulations of coupled acoustic and elastic wave propagation in both simplified models and the full realistic model show that most microseism energy is confined to sediment and water column waveguides. We also show that a significant portion of microseism energy is reflected back to the deep ocean by the continental slope, while only a small fraction of deep-ocean-generated microseism energy reaches land. We conclude that terrestrially observed microseisms are largely generated in shallow water on continental shelves. 2014-09-22T00:00:00Z Validation of elastic wave measurements of rock fracture compliance using numerical discrete particle simulations http://hdl.handle.net/10197/6117 Validation of elastic wave measurements of rock fracture compliance using numerical discrete particle simulations Möllhoff, Martin; Bean, Christopher J. We test various methods of quantifying the compliance of single and multiple rock fractures from synthetic ultrasonic data. The data are generated with a 2D discrete particle scheme which has previously been shown to treat fractures in agreement with linear-slip theory. Studying single fractures, we find that delays derived from peak amplitudes do not correspond to group delays, as might be expected. This is due to waveform distortion caused by the frequency-dependent transmission across the fracture. Instead the delays correspond to an expression for phase delays, which we derive from linear-slip theory. Phase delays are a unique function of compliance, whereas group delays are non-uniquely related to compliance. We believe that this property of group delays has hindered the wider application of deriving fracture compliances from traveltimes. We further show that transmission coefficients derived from waveform spectra yield more accurate fracture compliances than those obtained from ratios of signal peak amplitudes. We also investigate the compliance of a set of parallel fractures. Fracture compliance can only be determined from transmission coefficients if the fracture spacing is so large that the first arriving pulse is not contaminated by reverberations. In the case of contamination the direct measurement of group or phase delays is not practical. However, we demonstrate that in such cases of strong waveform distortion the coda wave interferometry method is very effective for determining relative fracture compliance. First break delays in the fracture set data are related to those observed in single fracture simulations. This means that fracture set compliance can be estimated from first break data if used together with numerical simulations. 2009-09-01T00:00:00Z Formalization of SLAs for Cloud Forensic Readiness http://hdl.handle.net/10197/6112 Formalization of SLAs for Cloud Forensic Readiness De Marco, Lucia; Ferrucci, Filomena; Kechadi, Tahar Cloud Computing is one of the most pervasive ICT changes of the last few years. Usually, Clouds offer a variety of Services, which are accessible over the Internet. These Services are regulated by some contracts called Service Level Agreements between Service providers and customers. The SLAs have already been introduced in Service Oriented Architectures in situations where some computing services need to be structured and regulated. In an SLA, the constraints of use, the duties and responsibilities of the parties involved, the charges and the service levels to guarantee, etc., are clearly stated by dedicated clauses. Despite the efforts made in systems security and the standardisation of SLAs, Cloud Services continues to suffer from various cybercriminal attacks, and unfortunately this phenomenon is likely to escalate within the next few years. It becomes urgent to take some countermeasures against these illegal practices to increase both the customer trust and quality of services of such new technologies. One of the alternatives for this phenomenon is to provide an efficient cloud Forensic Readiness System (FRS) to prevent and alert the provider and/or customer of any suspect attacks or strange behaviour. Much attention has been given to FRSs and they have certainly moved from simple log files and monitoring to very sophisticated components involving both human experts and computer analysis tools. In this paper we study the effect of SLAs on FRSs. As SLAs may be different from one jurisdiction to another we believe that FRSs should also comply with jurisdiction for more efficiency and speed of isolating and resolving forensic cases. Therefore, we propose an FRS that takes into account automatically SLAs and issue warnings and alerts to its users (providers and consumers) based on the jurisdiction and the nature of security breach and attacks. These SLAs are presented to the system as a set of rules (clauses). This will also prevent illegal data transfers and communications among different jurisdictions. Part of this paper will be dedicated to the formalisation of these SLAs and study its consequences on the FRS architecture and functioning. The rest of the paper will be dedicated to the design and development of the FRS reference architecture integrating the proposed SLA formal model. 2nd International Conference on Cloud Security Management (ICCSM 2014), Reading, UK, 23-24 October, 2014 2014-10-01T00:00:00Z Clustering with the multivariate normal inverse Gaussian distribution http://hdl.handle.net/10197/6106 Clustering with the multivariate normal inverse Gaussian distribution O'Hagan, Adrian; Murphy, Brendan; Gormley, Isobel Claire; et al. Many model-based clustering methods are based on a finite Gaussian mixture model. The Gaussian mixture model implies that the data scatter within each group is elliptically shaped. Hence non-elliptical groups are often modeled by more than one component, resulting in model over-fitting. An alternative is to use a mean–variance mixture of multivariate normal distributions with an inverse Gaussian mixing distribution (MNIG) in place of the Gaussian distribution, to yield a more flexible family of distributions. Under this model the component distributions may be skewed and have fatter tails than the Gaussian distribution. The MNIG based approach is extended to include a broad range of eigendecomposed covariance structures. Furthermore, MNIG models where the other distributional parameters are constrained is considered. The Bayesian Information Criterion is used to identify the optimal model and number of mixture components. The method is demonstrated on three sample data sets and a novel variation on the univariate Kolmogorov–Smirnov test is used to assess goodness of fit. 2014-09-19T00:00:00Z A 13C-NMR study of azacryptand complexes http://hdl.handle.net/10197/5894 A 13C-NMR study of azacryptand complexes Wild, Aljoscha A. C.; Fennell, Kevin; Morgan, Grace G.; Hewage, Chandralal; Malthouse, J.Paul G. An azacryptand has been solubilised in aqueous media containing 50% (v/v) dimethyl sulphoxide. 13C-NMR has been used to determine how the azacryptand is affected by zinc binding at pH 10. Using 13C-NMR and 13C-enriched bicarbonate we have been able to observe the formation of 4 different carbamate derivatives of the azacryptand at pH 10. The azacryptand was shown to solubilise zinc or cadmium at alkaline pHs. Two moles of zinc are bound per mole of azacryptand and this complex binds 1 mole of carbonate. By replacing the zinc with cadmium-113 we have shown that the 13C-NMR signal of the 13C-enriched carbon of the bound carbonate is split into two triplets at 2.2 °C. This shows that two cadmium complexes are formed and in each of these complexes the carbonate group is bound by two magnetically equivalent metal ions. It also demonstrates that these cadmium complexes are not in fast exchange. From temperature studies we show that in the zinc complexes both complexes are in fast exchange with each other but are in slow exchange with free bicarbonate. HOESY is used to determine the position of the carbonate carbon in the complex. The solution and crystal structures of the zinc–carbonate–azacryptand complexes are compared. 2014-07-29T00:00:00Z Piezoelectricity in collagen type II fibrils measured by scanning probe microscopy http://hdl.handle.net/10197/5892 Piezoelectricity in collagen type II fibrils measured by scanning probe microscopy Denning, Denise; Kilpatrick, J. I.; Hsu, T.; Rodriguez, Brian J.; et al. The converse piezoelectric effect in collagen type II fibrils, the main collagen constituent in cartilage, was investigated using piezoresponse force microscopy. The fibrils exhibited shear piezoelectric behavior similar to that previously reported in collagen type I fibrils and followed the same cantilever-fibril angle dependence present for type I. A uniform polarization directed from the amine to carboxyl termini, as seen for collagen type I, was observed in all type II fibrils studied. The shear piezoelectric coefficient, d 15, however, for type II was roughly 28–32% of the value measured for type I fibrils. Possible explanations for the reduced piezoelectric coefficient of type II collagen are provided. 2014-08-11T00:00:00Z Nanoscale characterization of β-phase HxLi1−xNbO3 layers by piezoresponse force microscopy http://hdl.handle.net/10197/5891 Nanoscale characterization of β-phase HxLi1−xNbO3 layers by piezoresponse force microscopy Manzo, Michele; Denning, Denise; Rodriguez, Brian J.; Gallo, Katia We investigate a non-destructive approach for the characterization of proton exchanged layers in LiNbO3 with sub-micrometric resolution by means of piezoresponse force microscopy (PFM). Through systematic analyses, we identify a clear correlation between optical measurements on the extraordinary refractive index and PFM measurements on the piezoelectric d 33 coefficient. Furthermore, we quantify the reduction of the latter induced by proton exchange as 83 ± 2% and 68 ± 3% of the LiNbO3 value, for undoped and 5 mol. % MgO-doped substrates, respectively. 2014-01-01T00:00:00Z Theta-Burst Stimulation of Hippocampal Slices Induces Network-Level Calcium Oscillations and Activates Analogous Gene Transcription to Spatial Learning http://hdl.handle.net/10197/5877 Theta-Burst Stimulation of Hippocampal Slices Induces Network-Level Calcium Oscillations and Activates Analogous Gene Transcription to Spatial Learning Sheridan, Graham K.; Moeendarbary, Emad; Pickering, Mark; O'Connor, J. J.; Murphy, Keith J. Over four decades ago, it was discovered that high-frequency stimulation of the dentate gyrus induces long-term potentiation (LTP) of synaptic transmission. LTP is believed to underlie how we process and code external stimuli before converting it to salient information that we store as 'memories'. It has been shown that rats performing spatial learning tasks display theta-frequency (3–12 Hz) hippocampal neural activity. Moreover, administering theta-burst stimulation (TBS) to hippocampal slices can induce LTP. TBS triggers a sustained rise in intracellular calcium [Ca2+]i in neurons leading to new protein synthesis important for LTP maintenance. In this study, we measured TBS-induced [Ca2+]i oscillations in thousands of cells at increasing distances from the source of stimulation. Following TBS, a calcium wave propagates radially with an average speed of 5.2 µm/s and triggers multiple and regular [Ca2+]i oscillations in the hippocampus. Interestingly, the number and frequency of [Ca2+]i fluctuations post-TBS increased with respect to distance from the electrode. During the post-tetanic phase, 18% of cells exhibited 3 peaks in [Ca2+]i with a frequency of 17 mHz, whereas 2.3% of cells distributed further from the electrode displayed 8 [Ca2+]i oscillations at 33 mHz. We suggest that these observed [Ca2+]i oscillations could lead to activation of transcription factors involved in synaptic plasticity. In particular, the transcription factor, NF-κB, has been implicated in memory formation and is up-regulated after LTP induction. We measured increased activation of NF-κB 30 min post-TBS in CA1 pyramidal cells and also observed similar temporal up-regulation of NF-κB levels in CA1 neurons following water maze training in rats. Therefore, TBS of hippocampal slice cultures in vitro can mimic the cell type-specific up-regulations in activated NF-κB following spatial learning in vivo. This indicates that TBS may induce similar transcriptional changes to spatial learning and that TBS-triggered [Ca2+]i oscillations could activate memory-associated gene expression. 2014-06-20T00:00:00Z CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity http://hdl.handle.net/10197/5876 CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity Sheridan, Graham K.; Wdowicz, Anita; Pickering, Mark; Watters, Orla; Halley, Paul G.; O'Sullivan, Niamh C.; Mooney, Claire; O'Connell, David J.; O'Connor, J. J.; Murphy, Keith J. Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellular and molecular processes of hippocampal-dependent long-term memory consolidation including synaptic plasticity, synaptic scaling and neurogenesis. The chemokine, CX3CL1 (fractalkine), has been shown to modulate synaptic transmission and long-term potentiation (LTP) in the CA1 pyramidal cell layer of the hippocampus. Here, we confirm widespread expression of CX3CL1 on mature neurons in the adult rat hippocampus. We report an up-regulation in CX3CL1 protein expression in the CA1, CA3 and dentate gyrus (DG) of the rat hippocampus 2 h after spatial learning in the water maze task. Moreover, the same temporal increase in CX3CL1 was evident following LTP-inducing theta-burst stimulation in the DG. At physiologically relevant concentrations, CX3CL1 inhibited LTP maintenance in the DG. This attenuation in dentate LTP was lost in the presence of GABAA receptor/chloride channel antagonism. CX3CL1 also had opposing actions on glutamate-mediated rise in intracellular calcium in hippocampal organotypic slice cultures in the presence and absence of GABAA receptor/chloride channel blockade. Using primary dissociated hippocampal cultures, we established that CX3CL1 reduces glutamate-mediated intracellular calcium rises in both neurons and glia in a dose dependent manner. In conclusion, CX3CL1 is up-regulated in the hippocampus during a brief temporal window following spatial learning the purpose of which may be to regulate glutamate-mediated neurotransmission tone. Our data supports a possible role for this chemokine in the protective plasticity process of synaptic scaling. 2014-08-12T00:00:00Z Identification of a mutation in LARS as a novel cause of infantile hepatopathy http://hdl.handle.net/10197/5794 Identification of a mutation in LARS as a novel cause of infantile hepatopathy Casey, Jillian; McGettigan, Paul A.; Lynam-Lennon, Niamh; Regan, Regina; Conroy, Judith; Bourke, Billy; Lynch, Sally; Ennis, Sean; et al. Infantile hepatopathies are life-threatening liver disorders that manifest in the first few months of life. We report on a consanguineous Irish Traveller family that includes six individuals presenting with acute liver failure in the first few months of life. Additional symptoms include anaemia, renal tubulopathy, developmental delay, seizures, failure to thrive and deterioration of liver function with minor illness. The multisystem manifestations suggested a possible mitochondrial basis to the disorder. However, known causes of childhood liver failure and mitochondrial disease were excluded in this family by biochemical, metabolic and genetic analyses. We aimed to identify the underlying risk gene using homozygosity mapping and whole exome sequencing. SNP homozygosity mapping identified a candidate locus at 5q31.3–q33.1. Whole exome sequencing identified 1 novel homozygous missense mutation within the 5q31.3–q33.1 candidate region that segregated with the hepatopathy. The candidate mutation is located in the LARS gene which encodes a cytoplasmic leucyl-tRNA synthetase enzyme responsible for exclusively attaching leucine to its cognate tRNA during protein translation. Knock-down of LARS in HEK293 cells did not impact on mitochondrial function even when the cells were put under physiological stress. The molecular studies confirm the findings of the patients' biochemical and genetic analyses which show that the hepatopathy is not a mitochondrial-based dysfunction problem, despite clinical appearances. This study highlights the clinical utility of homozygosity mapping and exome sequencing in diagnosing recessive liver disorders. It reports mutation of a cytoplasmic aminoacyl-tRNA synthetase enzyme as a possible novel cause of infantile hepatopathy and underscores the need to consider mutations in LARS in patients with liver disease and multisystem presentations. 2012-07-01T00:00:00Z First implication of STRA6 mutations in isolated anophthalmia, microphthalmia and coloboma: a new dimension to the STRA6 phenotype http://hdl.handle.net/10197/5790 First implication of STRA6 mutations in isolated anophthalmia, microphthalmia and coloboma: a new dimension to the STRA6 phenotype Casey, Jillian; Kawaguchi, Riki; Morrissey, Maria; McGettigan, Paul A.; Nielsen, Jens Erik; Conroy, Judith; Regan, Regina; Kennedy, Breandán; Lynch, Sally; Green, Andrew; Ennis, Sean; et al. Microphthalmia, anophthalmia, and coloboma (MAC) are structural congenital eye malformations that cause a significant proportion of childhood visual impairments. Several disease genes have been identified but do not account for all MAC cases, suggesting that additional risk loci exist. We used single nucleotide polymorphism (SNP) homozygosity mapping (HM) and targeted next-generation sequencing to identify the causative mutation for autosomal recessive isolated colobomatous microanophthalmia (MCOPCB) in a consanguineous Irish Traveller family. We identified a double-nucleotide polymorphism (g.1157G>A and g.1156G>A; p.G304K) in STRA6 that was homozygous in all of the MCOPCB patients. The STRA6 p.G304K mutation was subsequently detected in additional MCOPCB patients, including one individual with Matthew-Wood syndrome (MWS; MCOPS9). STRA6 encodes a transmembrane receptor involved in vitamin A uptake, a process essential to eye development and growth. We have shown that the G304K mutant STRA6 protein is mislocalized and has severely reduced vitamin A uptake activity. Furthermore, we reproduced the MCOPCB phenotype in a zebrafish disease model by inhibiting retinoic acid (RA) synthesis, suggesting that diminished RA levels account for the eye malformations in STRA6 p.G304K patients. The current study demonstrates that STRA6 mutations can cause isolated eye malformations in addition to the congenital anomalies observed in MWS. 2011-12-01T00:00:00Z


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US Open 2014: Martin Kaymer outstanding at Pinehurst, says Colin Montgomerie
German now hot favourite the Open Championship at Hoylake
By Colin Montgomerie
Last Updated: 16/06/14 12:22pm
Colin Montgomerie says Martin Kaymer was 'head and shoulders above the rest' in the best US Open performance since Tiger Woods won by 15-strokes in 2000.
Kaymer cruised to an eight-shot victory over Rickie Fowler and Erik Compton at Pinehurst No 2, to add the US Open title to his US PGA Championship victory in 2010 and Players Championship victory last month.
The 29-year-old took a five-shot lead into the final round and was never fewer than four shots clear of his rivals across of week, on a course predicted to have a winning score of around par.
We're trying to make a case for the rest of them but really there was one guy head and shoulders above the rest.
Colin Montgomerie
Three-time US Open runner-up Colin Montgomerie told Sky Sports that Kaymer will go to next month's Open Championship at Hoylake as favourite, after becoming the fourth wire-to-wire US Open winner since 2000 and first German to win the Major.
Montgomerie said: "He didn't get the memo about being level par. There were just two other guys under par and they were just one-under.
"It was a one-horse race from day one. The race was really for second place; we're trying to make a case for the rest of them but really there was one guy head and shoulders above the rest.
"We know about this guy now, don't we?
"He goes to the Open Championship as hot favourite - with that putting stroke and that mind he's the one to beat - and as Players champion, US Open champion, what's next for him?
"I've run out of superlatives. It has been unbelievable golf and the best US Open golf we've seen since the year 2000 when Woods won by that terrific score at Pebble Beach.
"This has been a joy to watch."
Montgomerie - who captained Kaymer in his rookie Ryder Cup appearance at Celtic Manor in 2010 - says the German has learnt a lot from his drop down the rankings in 2011, following an attempt to change his swing for Augusta - and then missing the Masters cut four times.
"He's been learning there's, no question," said Montgomerie.
"He fell from No.1 in the world – eight weeks at No.1 in the world in 2011 to 63rd – but he's going to be almost back in to the top 10 and he can only go further now.
"I think he learnt physically and mentally about the game of golf and learnt a lot about his golf swing. Now he's found it and he's swinging the club the way he used to and he's back as a Major champion."
Kaymer will now almost certainly be included in Paul McGinley's European Ryder Cup team, something the Dusseldorf-born player has targeted during his rankings climb.
"He's a great asset to any Ryder Cup team," Montgomerie added. "We know what he did in 2010 and he was a great help to me then."
"He was fantastic help to Jose Maria [Olazábal] by holing that six- foot putt [in 2012] and I'm sure he'll be the same for McGinley this time around."
Butch Harmon, said: "He's right on his way. If he doesn't make the European Ryder Cup team, we'll take him on our American one, that's for sure!"


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Huntaway Lodge
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TripAdvisor Reviews Huntaway Lodge North Island
Travel Blogs from North Island
Madness in Mahia
... time she tried to stand up! We came back to shore for dinner eating fish that Ed, 'Sophie' and Victor had caught and sat around talking and drinking.
On Sunday the boys went back out early on the boat to try and see if they had any better luck fishing whilst the girls had a lazier morning before heading around the bay to go body boarding. The waves were pretty high but with Sophie giving some good lessons soon we were all flying along the beach before ...
New Zealand 2nd 2 weeks - North Island
... rated by Jacques Cousteau as one of the top 10 dive sights in the world. As you might expect from diving in New Zealand it was pretty cold in the water but we had great gear and we managed two 1-hour dives easily. As we have experienced every time we have been diving the visibility wasn't great. Saw loads of things though, a huge packhorse crayfish, lots of rays, yellow and speckled morays,big kingfish and a huge grouper. Owing to the current we stayed in the same area ...
... 3 tablespoons brown sugar
� 1 teaspoon ground ginger
� � teaspoon curry powder
� � teaspoon mixed spice
� � teaspoon salt
� Freshly ground black pepper
� � cup vinegar
� � cup sherry or red wine
� 1 tablespoon L&P sauce
� 1 tablespoon soy sauce
� 2 tablespoons tomato sauce
� 1 lemon, ...
Last Dinner with the Tomblesons
... and non threatening residence at Aerial Station.
We then headed to the next little pasture to meet Legs, her week old foul that she found stuck in a fence the day after she was born. Legs is just her name for now; she hasn't decided what to name it exactly. None of us have ever had the opportunity to see such a young horse, so this was a treat to all. (And slightly scary--we didn't know how the mom was going to feel about ...
Down the east coast
... beginning of a 21km long gravel road along the ocean, leading us to Tobi's favourite spot, the East Cape Lighthouse!! To see how beautiful it can really be there we got up at 5.30 for the sunrise, running up the mountain for 20 minutes. And it was absolutely amazing!! To refresh ourselves we jumped over the fence with the sign 'private property' to sneak our way to a lonesome beach, where Tobi has been last time. Bogging down and ...
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Is it possible to have a ClickOnce deployment that only registers a DLL on the user's machine or can it only deploy WinForms/WPF applications?
Take the 2-minute tour ×
Stack Overflow is a question and answer site for professional and enthusiast programmers. It's 100% free, no registration required.
ClickOnce is all about installing programs without altering the configuration of the machine. Even if you could deploy a DLL, nobody would be able to find it back.


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Dr. Sasha C. Thomas, MD
Internal Medicine
- 4320 Seminary Rd
Alexandria, VA 22304
- 1 Location
- (703) 504-3065
Dr. Sasha C. Thomas graduated from the Emory University School of Medicine in 2000. He works in Alexandria, VA and specializes in Internal Medicine. Dr. Thomas is affiliated with Inova Alexandria Hospital. He speaks English and Spanish.
Gender: Male
Languages Spoken: English, Spanish
Internal Medicine
Medical School: Emory University School of Medicine; Graduated 2000
4320 Seminary Rd
Alexandria, VA 22304
(703) 504-3065
Fax: (703) 504-3086
Practice Website: Not Available
Accepting New Patients: Yes
Medicare Accepted: Yes
Medicaid Accepted: Yes
Not Available


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Front Yard Pictures in Winter
greengirl1March 24, 2009
Hi Gardeners
I am wondering if you all could post pictures of your front yard garden in winter. I have been gardening for last 2-3 years and this winter I realized that my front yard looks awful in winter. Now I am planning to add some dwarf conifers and evergreens for year round interest. Any ideas and pictures are appreciated!