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Eastside Inside: Haute Happenings East of Lake Washington
Eastside Inside is all about what's haute and happening on the Eastside of Seattle. Events, live music, entertainment, theatre, galas, restaurants, happy hours, comedy clubs, parties, people, kids, animals, something interesting for everyone on the Eastside.
Dr. Funk on the 4th for food, funk & fun…
Yes, the Dr. is in! That is, the Dr. of Funk! This Friday you can "get your funk on" with the whole family from 8:30 PM to right up to when the fireworks start at 10:00 PM! "Dr. Funk on the 4th – 2008″ They will be playing at Fort Dent Park in Tukwila and the fun is open to all ages! [Read More]
FREE Fireworks & Fun on the Fourth! Happy 232nd Independance Day America!
FREE, FREE, FREE "Let It Be, Let It Be… [Read More]
Eastside restaurants ralley & rescue with the impending recession…
Although we are just seeing the beginning signs of an impending recession, if some of us haven't already felt it, it is something that is unfortunately looming. There is good news though! We've got some help with local Eastside restaurants. Here are some of the participating restaurants, and what they've got to offer: [Read More]
"Greenway Days Festival" – Do you know your Greenway?
It's 100 miles of National Scenic Byway and is a non-profit organization based in Seattle that helps protect the land that stretches over 100 miles along interstate 90 from the shores of Puget Sound in Seattle, over Snoqualmie Pass and into Central Washington. It includes over 750,000 acres of local, state and federal land in a trust for the public good. It encompassess protected and working forests, farms, historic towns, lakes, campgrounds, rivers, trails and wildlife habitats. [Read More]
Celtic Mondays at Wilde Rover in Kirkland with Geoffrey Castle, Dan Connolly & friends…
Seeking a little action on a mostly sleepy Monday? Mondays are alive and well on the Eastside! Well you're in luck of the Irish at Wilde Rover when the place will be filled with the beautiful and mesmerizing music of Geoffrey Castle while he also welcomes Dan Connolly, Eric Robert and drummer Jeff Riley. You've just got to get down to this cool Irish Pub/Restaurant to hear these guys, they're a special treat! And hey, their big back deck will be open to enjoy the beautiful weather today! "Celtic Mondays at Wilde Rover w/Geoffrey Castle & Friends" Located at: 111 Central Way, Kirkland| (425) 822-8940| www.wilderover.com For more information, please visit: "Geoffrey Castle" [Read More]
Blue skies, water sports and weekends full of all kinds of fun…
This weekend was full of all kinds of fun & surprises especially with the clouds parting and the blue skies appearing with warmer temperatures making their way up to a wopping 70+ degrees. It's always nice to see good weather, especially when you've got some fun outdoor activities to enjoy! Well regardless of the weather, my friends and I decided to make the best of the weekend with a full lineup of fun things to do. Starting out with an awesome breakfast at one of the best places for breakfast on the Eastside, called "The Game". It's a cool little diner type of restaurant in the Juanita/Kirkland area with big screens, "Fremont Fair 2008″ and a nice deck to sit out on during the sunny days, etc., we had a good spot out on the deck, and so we enjoyed the sunshine. Some friends of mine all met there for breakfast (and a cocktail) before we made our way over to the Fremont Fair to take in some of the painted nudies and clever parade themes, etc. Wow, the painted nudies were out in droves [Read More]
Fun events for the whole family in Mercer Island, Bellevue, Kirkland, Redmond & more…
We here in the Pacific Northwest are tough cookies when it comes to weather, and although this year so far hasn't been the best weather wise, we do know how to layer our clothes, put on our hats, etc., so we've got to get tough now through these gloomy times and keep our attitudes up even when we have less then stellar weather – because when the weather does get better, we just appreciate it all the more! I say, "forget the weather, enjoy these fun-filled family events coming up anyway"! [Read More]
Sip and nosh where it's posh, and the view is, "Oh my Gosh"!
One of my favorite spots in the whole Pacific Northwest, the "Wooley Toad" up at the Golf Club at Newcastle, and just happens to be on the Eastside, is going to start having "premiere tastings"! The view from the "Wooley Toad", Photo by Lisa Hilderbrand The Wooley Toad is excellently appointed with vaulted ceilings, plush sofas and chairs upholstered in luxurious leather and corduroy, a large fireplace, and soaring barreled ceilings contribute to its gracious surroundings, while a feature window frames sweeping views of Newcastle 's golf courses, Seattle urban skylines and mountain ranges. [Read More]


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SAN FRANCISCO (AP) — A jury decided Friday that a prestigious venture capital firm did not discriminate or retaliate against a female employee in a case that debated gender imbalance and working conditions for women in Silicon Valley.
WASHINGTON (AP) — Senate Minority Leader Harry Reid, a pugnacious and glamour-averse tactician who united Democrats to help deliver tough victories for President Barack Obama, said Friday he's retiring next year. He immediately endorsed brash New York Sen. Chuck Schumer to succeed him as leader of a party desperate to regain the Senate majority.
SAN FRANCISCO (AP) — A California woman and her boyfriend say kidnappers entered their house in the middle of the night this week, abducted the woman and held her for ransom before releasing her two days later. Police are skeptical.

subset: commoncrawl


text: GALLERIES Mark Rylance 0 28 Back to Top ▲ Mark Rylance Mark Rylance Mark Rylance Picture 6 AskMen Editors Share on Facebook Share on Twitter 0 Shares Next Page Comments Show Comments More Like This Promoted Around the Web Special Features Special Feature 50 Ways To Look Better Than You Do Now. Smooth Up, Man. Read More AskMen Exclusive Want To Win $1,000 To Stock Your Home Bar? Read More


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8 Dangerous Toys From Years Past
By Chris Lane
Doctor Who: The New Doctor Reviewed
By Jef With One F
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Comicpalooza's Grand Resurrection
By Jef Rouner
Dumb Reasons to Hate Presidents
By Jef With One F
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This is an almost winsome production of a play about regret and grief, and it exemplifies the sort of theatrical experience that lingers in the night, long after the theater has closed down and all the actors have gone home.
Hushabye Mountain runs through December 19 at Theater LaB Houston, 1706 Alamo, (713)868-7516. $20-$22.
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Robert Gallegos was born at Parkview Hospital on 75th and Harrisburg and was raised in Magnolia Park. Robert attended Immaculate Heart of Mary Catholic Church & Elementary School, where he was baptized, received his Holy Communion and was confirmed. He attended Edison Junior High School and was active in both the marching and stage bands. Robert became president of Immaculate Heart of Mary Catholic Youth Organization (C.Y.O.) and
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Cruden to decide between 'Canes and Chiefs
ESPNscrum Staff
July 5, 2011
Cruden has had a disappointing season with his Wellington franchise in Super Rugby © Getty Images
All Blacks fly-half Aaron Cruden is set to announce next week whether he will stay with the Hurricanes or opt to join the Chiefs.
Cruden is one of the most sought after properties in New Zealand rugby with the Blues also expressing an interest in the stand-off. However the 22-year-old has opted against a move to the Auckland club but will find the prospect of linking up with All Blacks assistant coach Wayne Smith and his former Manawatu and New Zealand Under-20 coach Dave Rennie at the Chiefs an attractive proposition ahead of next season's Super Rugby competition.
"It's just come down to those two now, I had a call from (Blues coach) Pat Lam as well which was really nice to know that other teams are looking at you, but at this point it's just between the Chiefs and the Hurricanes," Cruden told reporters at an All Blacks training camp in Wellington on Tuesday.
"I think when any other franchise come talking to you you've got to have a think about it. It's not as simple as just saying 'no see you later'; it's a professional industry now so you've got to make the best decision for yourself and your family."
Cruden will now discuss his future with his partner and will look at where fellow All Blacks and Hurricanes' team-mates Cory Jane and Piri Weepu decide their future lies ahead of the 2012 Super Rugby competition. The Hurricanes have already bid farewell to two former stalwarts, Andrew Hore and Ma'a Nonu, but will hope to keep hold of Cruden, Weepu and Jane. For Cruden, "personal development" is key in any future decision.
"It will be about my own personal development, coaching and team culture," Cruden said. "I suppose we've got to go away and write a pros and cons list to make the decision that is best suited for me and my partner.
"I think the makeup of squads sort of has a little bit of an effect so I've been talking to Piri and Cory Jane, just trying to pick their brain about what their thinking is and that will help. Regardless of the actions and incidents that happened with the Hurricanes this year, I would be thinking about it," he said.
Cruden was joined at the All Blacks camp in Wellington by 24 other World Cup hopefuls. They included Tony Woodcock, who has missed a large chunk of the season with a foot injury, Israel Dagg, who is recovering from a thigh injury, and Isaia Toeava who is struggling with a hip injury. Wing Hosea Gear sat out training with the ankle injury which forced him out of the training session conducted by Gordon Tietjens last week. The New Zealand sevens supremo takes the bulk of the squad for another session on Wednesday.
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Biker Jim's serves unique gourmet hot dogs like the Wiener Wellington.
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Emeril finds out why some people will wait for two hours for a dog in L.A.
Aarti Sequeira's dishes pay tribute to her greatest culinary teacher.
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Alie and Georgia gain inspiration from hot dogs for a beer-based cocktail.
How much do you really know about hot dogs? Check out some frank trivia.
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Ex-UF player Hornsby sentenced to probation, prison tour
Published: Monday, December 15, 2008 at 12:14 p.m.
Last Modified: Monday, December 15, 2008 at 12:14 p.m.
Former University of Florida football player Jamar Hornsby must tour Florida State Prison as a part of his sentence for using a friend's credit card after her death.
Hornsby, 21, of Jacksonville, was sentenced Monday to a year of probation but no jail time.
He pleaded no contest to four misdemeanor counts of fraudulent credit card use for buying nearly $3,000 worth of gas on a credit card issued to Ashley Slonina, a UF student who died in an October 2007 motorcycle accident.
The card use was discovered by Slonina's parents month after her death. The Slonina family was in court Monday morning to accept a letter of apology from Hornsby. State Attorney Bill Cervone said that although the theft complicated the family's efforts to deal with Ashley's death, the Sloninas accepted Hornsby's apology and the plea deal.
"They expressed to me that they wanted him to have a productive life," Cervone said.
After adjudicating Hornsby guilty, Judge Victor Hulslander ordered him to serve a year of probation, pay the Sloninas for the nearly $3,000 worth of gas he charged on the card (a condition he has already met) and, within the next 10 months, pay $5,400 in investigative costs and about $500 in court costs and assessments. Within three months Hornsby must tour the prison containing the state's Death Row and write an essay to the judge about the tour.
Hornsby was listed as a junior on the Gator football team, and was listed in the spring 2008 depth chart as a second-team free safety. After his release from the team following his arrest, he transferred to East Mississippi Community College, where he was recently named to the 2008 NJCAA All-American Second Team.
On its Web site, East Mississippi identified Hornsby as ranking among the national defensive leaders with 111 total tackles on 64 solos and 47 assists this season.
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- Seeds - The Sims 3
Back to The Sims 3 Guide Index
More for this game: More Sims 3 on SuperCheats.com
Seeds can be found across Sunset Valley, though particularly by Landgraab Industries Science Facility and usually close to roadsides. The most lucrative seed to find is that of the Death Flower. The flower itself can be harvested once from Pleasant Rest Graveyard, or found by chance while fishing. It allows you to buy more time from the Grim Reaper should your Sim die. It is not valuable in itself however, unlike the Money Tree, which can fetch 800 Simoleons per 'money bag' produce if in perfect condition.
The Death Flower, by the entrance to Pleasant Rest Graveyard.
Of course, to make use of the seeds, plant them in your garden and look after them well. You can then sell their fruit.
Added 4th Jun 2012, ID #148882
Added 10th Feb 2012, ID #113703
Added 1st Dec 2011, ID #91920
Added 2nd Sep 2011, ID #71903
Added 22nd May 2011, ID #44385


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ChiSox, Peavy silence Twins
MINNEAPOLIS — Start by quality start, Jake Peavy is putting the shoulder problems that once threatened to derail his career further and further behind him.
Adam Dunn and Dayan Viciedo hit consecutive homers to back another strong start from Peavy and lead the Chicago White Sox to a 4-2 victory over the Minnesota Twins on Tuesday night.
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Companies that work to create healthy workplaces will be honored next month as part of the annual Michigan's Best and Brightest in Wellness program, the groups sponsoring the program said.
Meijer announced that it is expanding its mPerks digital coupon program to include pharmacy purchases, allowing customers to personalize their savings and earn rewards in the areas they shop the most whenever they fill a prescription.
Midwestern retailer Meijer announced that it is preparing to hire thousands of new team members for its stores in response to company growth and in preparation for the fall and holiday selling seasons.
Despite having its headquarters and a significant presence in Michigan, mass-merchandise retailer Meijer hasn't opened any stores in the state's largest city, but that will change Thursday.
Mass merchandise chain Meijer is set to open its first store in the city of Detroit later this month, according to published reports.
Meijer will open two new stores in northern Indiana, the mass merchandise retailer said.
Meijer will sell cupcake stands customized in local school colors under a partnership with the stands' Michigan-based manufacturer.
Meijer will open its 200th store next week, the mass merchandise retailer said.
A campaign run by Midwestern mass-merchandise chain Meijer to raise money for food banks has netted more than half a million dollars, the company said.
Five regional retailers — including mass-merchandisers Meijer and Fred Meyer — are selling a mobile point-of-sale credit card processing system compatible with most smartphones and tablets in their stores.


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Super Glassy look
OTA support added
Xposed installer and gravity box added
Density changer
Intelligent cover lock
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Based on Stock ROM V13 Spice Mi-535
Fast, smooth, stable
3G active sim card switch
Latest GAPPS built-in
Touchpal Keyboard
Blow/Shake to unloack
Miui notes
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Beautiful calculator
Sound Tweaks
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i am no way responsible if you ruin or brick your phone during installation of this ROM.
how to install:
1.Reboot to recovery
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4.Factory Reset
5.Wipe System
6.Install ROM
for better and bug free performance,I suggest to first flash Spice Stock ROM V13
Credits: @Spice for base ROM,if I forget anyone please PM me,I will add.
Last edited by Atrvscet; 3rd February 2014 at 07:12 AM.


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Cuba Gooding Jr. will star as Dr. Benjamin S. Carson in TNT telepic "Gifted Hands: The Ben Carson Story." Pic tells the tale of Carson's rise from a frustrated inner-city kid to director of pediatric neurosurgery at Johns Hopkins U. Hospital. Gooding Jr. was last seen in "American Gangster."
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3 bedroom farm house for sale Leete Walk, Pantymwyn, FlintshireReid and Roberts Estate Agents are delighted to offer For Sale Alyn Boarding Kennels and Cattery which is set in an area of outstanding natural beauty on the edge of Loggerheads Country Park. This a well established local business which has outstanding reputation with a returning client basis. Of... More details ›
£450,000 Offers in Excess of
Offers in Excess of £450,000
4 bedroom detached house for sale Cefn Bychan Road, PantymwynTown & Country are pleased to offer to the market this superbly appointed Four Bedroom Detached Home with Double Garage. Situated in the most sought after location within the village of Pantymwyn as it has stunning far reaching views of the valley and Clwydian Range beyond. In brief the spac... More details ›
4 bedroom detached house for sale Cefn Bychan Road, Pantymwyn, CH7An exceptional four bedroom detached property of individuality set within mature gardens in this noted area on the fringe of Pantymwyn village with outstanding views towards the Clwydian Range and Moel Famau, a designated Area of Outstanding Natural Beauty. Affording immaculately presented and v... More details ›
4 bedroom detached house for sale Cefn Bychan Road, Pantymwyn, CH7A unique, architect designed, timber-framed, weatherboard and shingle clad four bedroom detached house offering spacious accommodation which has benefited from refurbishment throughout to a high standard, standing within mature and partially wooded grounds to a slightly elevated setting commandin... More details ›
4 bedroom detached house for sale The Tudors, PantymwynTown & Country are delighted to offer to the market this beautiful 'Tudor Style' home. An absolute must see property, this outstanding, well presented, detached house needs to be viewed to be fully appreciated. Standing within spacious landscaped gardens, this superbly appointed and versatil... More details ›
4 bedroom detached house for sale Bancroft, The Tudors, Pantymwyn, FlintshireEvery now and then something a little special comes along...Just step inside this stunning property and you will see why! Bancroft is a beautifully presented four bedroom detached Tudor style family home which must be viewed to appreciate its wealth of charm, character and versatility. The pro... More details ›
4 bedroom detached house for sale Cefn Bychan Road, PantymwynTown and Country are pleased to offer to the market this individual build larger than average Four Bedroom Detached home finished to a very high standard and situated in the sought after semi-rural village of Pantymwyn. In brief the well presented accommodation comprises of: Enclosed Porch, Recep... More details ›
4 bedroom detached house for sale Cefn Bychan Woods, Mold, Flintshire, CH7Housesimple are proud to present this beautifully presented 4 bedroom detached house set in a stunning rural location overlooking Loggerheads Country Park. The property is offered with no forward chain. More details ›
Reduced on 14/01/2015 by Housesimple Online Estate Agents, Nationwide. Call: 0845 603 9909 Call rates may vary
4 bedroom detached bungalow for sale Pen-Y-Clawdd, Cilcain Road, Pantymwyn, FlintshireSEMI RURAL LOCATION - MUST BE VIEWED - Well presented, individual four bedroom detached bungalow located in the popular semi rural village of Pantymwyn. The property comprises of 4 Bedrooms, 2 En Suite, Family Bathroom, Lounge, Large Kitchen/Diner finished to an extremely high standard and Sun Ro... More details ›
3 bedroom detached house for sale Caer Gog, Pantymwyn, Flintshire** Village Location ** Super Fast Broadband @ 80mps ** Viewing Recommended **Reid & Roberts Estate and Letting Agents are pleased to offer For Sale the above Three/ Four Bedroomed Detached House situated in sought after cul de sac in the the peaceful village of Pantymwyn. The property has recent... More details ›
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Jeffery Smith was living in Missoula, Montana, and was into his eighth year as a psychiatric case manager when his own struggles with clinical depression began. Eventually, all his prescribed antidepressant medications proved ineffective. Unlike many such personal accounts, Where the Roots Reach for Water describes what happened after Smith decided to give them up. Trying to learn how to make a life with his illness, Smith sets out to get at the essence of--using the old term for depression--melancholia.
What he learns utterly transforms his life. Deftly woven into his "personal history" is a "natural history" of this ancient illness-a natural history that surveys, as we might expect, recent neurobiological research and speculation about depression's evolutionary purpose. But Smith also draws on centuries of art, writing, and medical treatises inspired by the illness and its very near kin, the melancholic temperament. His imaginative natural history of melancholia touches on mythology, anthropology, religious history, love and sex, philosophy, and our relationship with landscapes.
In addition, Smith tells numerous instructive stories of the men and women--from commoners to artists, from scientists to saints--who fitted their lives to melancholia before the advent of "seratonin reuptake inhibitors," twelve-step groups, or talk therapy, and he contemplates why contemporary America has become the "Prozac nation."
In describing the contours of melancholia's landscape, Smith poignantly finds his place within it. His attempts to forge a meaningful life within the confines of his seemingly invincible illness also take us across a number of vividly rendered physical landscapes, from the Appalachian foothills of Ohio and West Virginia, where he was born and raised, to the American West, where most of this narrative unfolds. In the process, he abandons his mental health career. A lifelong cynic, he finds faith and struggles to sustain it. He mends fences with his family. He falls in love, and for the first time stays there.
Where the Roots Reach for Water is a provocative and highly original memoir that recovers for us a trove of stories and ideas that, while long obscured, can teach us how we in this new "Age of Depression" might acclimate ourselves to melancholia's sundry lives.
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Vasily Petrenko in conversation with Darren Henley
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29 Nov 2012 Accountancy Age
By Rachael Singh
DELOITTE AND KPMG have been named in a lawsuit filed by a Hewlett Packard shareholder, following the announcement that the IT company overvalued its acquisition of Autonomy by billions of dollars.
The legal claim, filed this week in California, alleges that Deloitte, Autonomy's auditor, and KPMG, brought in to conduct some due diligence work on the acquisition, missed numerous red flags, Reuters reports.
Hewlett Packard acquired Autonomy in 2011 for around $11bn (£6.87bn). However, just 15 months after the deal HP was forced to write down $8.8bn, the majority of which HP claims was linked to improper accounting at Autonomy.
HP chief executive Meg Whitman (pictured) told analysts on the day of the write-down announcement that HP had relied heavily on the financial data audited by Deloitte, and brought in KPMG to essentially audit Deloitte's work in a due diligence exercise.
The lawsuit, filed by HP shareholder Philip Ricciardi, also named several HP board directors, officers and former executives, including HP ex-CEO Léo Apotheker, for alleged breach of duty and negligence for their role in the acquisition.
This is the second lawsuit filed against HP this month. Investors have filed a suit against HP claiming it knew that statements from its Autonomy acquisition were misleading, which led to the write-down.
PwC carried out a forensic review of Autonomy's accounting practices following a whistleblower's accusations of accounting irregularities in Autonomy prior to its take-over.
A KPMG spokesman said:"The firm's only role was to provide a limited set of non-audit-related services.
"Within the narrow scope of non-audit tasks KPMG did perform, we can say with confidence that we acted responsibly and with integrity. Our professional obligations and client confidentiality agreements prevent us from speaking in any greater detail without HP's consent."
Deloitte has also previously defended its audit work at UK technology company Autonomy.
"Deloitte categorically denies that it had any knowledge of any accounting improprieties or misrepresentations in Autonomy's financial statements at the time of the write-down announcement," said a Deloitte spokesman.
"We conducted our audit work in full compliance with regulation and professional standards."
Citigroup analysts have criticised the way financial reporting is policed by the UK's accounting watchdog following the Autonomy and HP issues.
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In a report submitted to foreign secretary William Hague, experts warn that unless it signs up to the treaty, Britain will be largely incapable of protecting wrecks lying beyond its waters.Read more
A group of leading archaeologists and historians urge Britain to join 45 other nations in ratifying the 2001 UNESCO convention on the protection of the underwater cultural heritage
MK: What do you do? I ran into some confusion trying to set this interview up, so lets take a closer look at what you are trying to do. Obviously you are not treasure hunters, so what are you doing?Read more
Millis Keegan interviews Odyssey Marine Exploration's Principal Marine Archaeologist Neil Cunningham Dobson
— April 2009


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Humorist's Ohio Home On National Register Of Historic Places
The suburban ranch-style home in Ohio where humor writer Erma Bombeck launched her nationally syndicated column has been added to the National Register of Historic Places.
State Auditor Dave Yost says no additional irregularities in attendance and enrollment practices have been found in the second round of his statewide data-tampering probe.
The teenage suspect in the slayings of three men lured by phony Craigslist job offers acknowledges he had chances to report the alleged triggerman to police but never did so.
According to state figures released Tuesday, the unemployment rate for central Ohio fell from 6.0 percent in August to 5.7 percent last month. That's the lowest level in more than more than four years and more than a full percent below the current statewide average.
A judge has ordered a central Ohio man held without bond after he was accused of gunning down a man who went to check on a possible break-in at his rental property.
The Oxford, Ohio college says it will discipline two male students responsible for putting an offensive flier about rape in a coed dorm bathroom.
A Columbus man becomes the first person convicted in West Virginia on federal bath salts distribution charges and will spend two years in prison.
President Obama and Vice President Joe Biden hosted a rare joint-rally Tuesday in Dayton.
The group that's backing a proposed change to Ohio's constitution over redistricting is putting ads on the air statewide. Opponents insist the ad is misleading.
Ohio voters are asked once every 20 years if they want state leaders to meet to propose constitutional amendments.


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BBB Business Review
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Phone: (619) 793-5877 2188 Crownhill Rd , San Diego, CA 92109 View Additional Web Addresses
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Business ManagementMr. Robert Mitchell, President
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Health & Diet Products - Retail Sporting Goods - Retail Sportswear - Retail


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Molecular Multitasker
April 1, 2014|
Scientists create a way to isolate mRNA from a single living cell within a tissue.
April 1, 2014|
Scientists create a way to isolate mRNA from a single living cell within a tissue.
April 1, 2014|
Researchers show that cancer stem cells can exist in two distinct and interconvertible states.
March 31, 2014|
Rodent models of Huntington's disease show dysfunctional cysteine production, and adding the amino acid to their diets seems to relieve symptoms.
March 31, 2014|
Stem cells supposedly derived by the new method of stimulus-induced acquisition of pluripotency may have come from mouse strains other than those claimed.
March 14, 2014|
Whole-genome sequencing in the clinic; blood-based biomarkers predict future cognitive problems; how some pain meds inhibit bacterial growth; ResearchGate launches Open Review
March 11, 2014|
Small study suggests that whole-genome sequencing faces several hurdles before it can be used routinely in the clinic.
March 3, 2014|
A single molecule emitted by male goats may influence female goat physiology and behavior.
March 1, 2014|
Once believed to be irrevocably differentiated, mature cells are now proving to be flexible, able to switch identities with relatively simple manipulation.
March 1, 2014|
Unlike the usual smooth, spherical shape of exosomes, glioblastoma-derived exosomes appear to have long nanofilaments protruding from their surfaces.
March 1, 2014|
For the first time, researchers quantify the mechanical forces cells exert on one another.


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When I first started getting serious about food storage, I found myself facing an entirely new vocabulary of food storage terms. It should come as no surprise that one of those terms was "Oxygen Absorber". At the time, I had no clue as what they were and how to use them.
Oxygen absorbers, also known as O2 absorbers, are a mystery to many. Not a week goes by when I am not asked for guidance as to how to use them. Rather than answer those questions individually, today I am sharing an updated printer on oxygen absorbers with just enough information to get you started on the road to successfully storing bulk foods for the long term.. . . Read More


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Nimrod Lake Quarry Cove Park Campground
When the world is just too much, and you need to get away from it all, there are very few things that satisfy the soul like getting back to nature. Now, whether your version of "roughing it" includes a private toilet or not, you'll agree that waking up to the sound of birds is a great way to clear the mind. And when you're ready to make your getaway plans, we're here to help.
Depending on the time of year it is when you're planning your trip to Nimrod Lake Quarry Cove Park Campground, you'll want to check the local fire danger levels to make sure you won't be denied your longed-for camp fire and roasted marshmallows. And just in case you think you'll need a glimpse of something other than nature for a few hours, don't forget to check out the points of interest that are nearby.
It's never too early to make reservations at Nimrod Lake Quarry Cove Park Campground in Arkansas. The best campgrounds and cabins fill up fast, so we recommend that you check availability and book your trip right away.
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- Cowhide Cove Campground
- Piney Bay Park Campground


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Dec 07, 2012 at 11:31PM EST
Technically a meme, seeing it has been used a lot
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- News
- Local
- Sports
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- Politics
- Opinion
- Lifestyle
- Entertainment
- Obituaries
- Classifieds
- Autos
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- Jobs
Rebecca Bergman, who will become the 17th president, is a top Medtronic executive.
Updated: February 28, 2014, - 11:09 PM
Season-ticket holders will be able to check out model suites and sit down and view the field much as they will when the real thing opens.
Updated: February 26, 2014, - 12:40 PM
No federal law was violated and the information is not private, said U.S. District Judge David Doty.
Updated: February 22, 2014, - 06:04 AM
On Thursday, a critical funding source, the Counties Transit Improvement Board (CTIB), sent a sharply worded letter to Metropolitan Council Chair Susan Haigh delivering the ultimatum. The board said that cities must act now or lose future funding.
Updated: February 20, 2014, - 09:43 PM
No one was injured and all debris fell within the demolition safety zone, so no passersby were at risk of injury. But investigators are trying to determine what happened.
Updated: February 18, 2014, - 02:49 PM
In 2010, Lois Mineau, volunteer coordinator at the Hennepin County Home School, was looking for someone to teach a basic...
Updated: February 17, 2014, - 07:21 PM
The simulation involved both mannequins and living colleagues from the hospital who stumbled in on their own or were wheeled in needing tourniquets, breathing tubes, head scans and surgery.
Updated: February 13, 2014, - 09:00 PM
Minneapolis balked at request to burn more refuse at HERC, so city asked to come up with composting plan.
Updated: February 12, 2014, - 09:50 AM
The nation's second lady from 1977 to 1981 "was sort of the needle on the compass of truth and beauty."
Updated: February 09, 2014, - 06:10 AM
The seat licenses for the new stadium will cost fans from $500 to $9,500 each.
Updated: February 08, 2014, - 08:17 AM


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Is your resume in need of a little disruption?
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making things work better.
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StartUpHire is the place to find CRM jobs in and near . Review the list below of CRM jobs. These CRM jobs represent some of the most rewarding careers available. You can refine your job search for CRM jobs in by adding a job title, company name, or keyword to the search box above … or click the "Advanced Search" link for more options. Don't see the employment opportunity you're looking for? Check back soon for more CRM jobs in , or sign up for an email alert (link in upper left) to receive periodic updates on new CRM jobs in , .
More information about this job: What We're Looking For: Experienced Enrollment Services Specialist who has worked with a selective, regionally accredited university to assist staff and students throughout the financial aid and matriculation process. Responsibilities Include,3/11/2015 Landover, MD Save This Job
The Vice President of Sales is responsible for developing, executing, and continuously improving SmartPak?s direct sales channel, focused primarily on equine boarding barns/stables. The VP of Sales will partner with SmartPak?s CEO, Chief Marketing Officer, and head of Customer3/11/2015 Plymouth, MA Save This Job
Company Description Alfresco provides modern software built on open-standards that unlocks the power of business-critical content. With control that IT demands and simplicity that end users love, Alfresco's open source technology enables global organizations to collaborate more3/11/2015 San Mateo, CA Save This Job
Customer Service Representative Posted: February 6, 2014 Type: Full-time Reports to: Customer Service Team Leader Summary Deliver an exceptional customer experience to the ESM Solutions user community. Responsibilities include but are not limited to: Become a subject3/11/2015 Warrington, PA Save This Job
Territory Sales Manager ModSpace seeks a hunting and closing professional with solid technical and networking ability for our busy Miami, FL location. This outside prospecting professional is responsible for identifying and closing ModSpace business opportunities across3/11/2015 Miami, FL Save This Job
Mirantis is seeking motivated, energetic self-starters who want to join our dynamic and rapidly growing account development team. This is a rare opportunity to join a well-funded startup, a proven leader with a solid track record in a fast-growing, disruptive market. In this role3/11/2015 Mountain View, CA Save This Job
Outbrain is seeking a Sales Engineer to play a key role in expanding our business. The Sales Engineer will be a key technical resource and advisor during the sales cycle and will provide technical suggestions and advise the sales team on the most suitable3/10/2015 New York, NY Save This Job
Outbrain is looking for a seasoned, process-oriented Director of Business Operations to help set the direction for the growth of the business line and make sure that all teams run smoothly and efficiently. This is a key role in helping Outbrain continue to grow and scale3/10/2015 New York, NY Save This Job
About Gilt Gilt.com is an innovative online shopping destination offering its members special access to the most inspiring merchandise and experiences every day at insider prices. Gilt continually searches the world for the most coveted brands and products, including fashion for3/10/2015 New York, NY Save This Job
ID 2015-1032 # of Openings 2 Location FirstFuel Posted Date 2/6/2015 Category Sales More information about this job: Overview: Our Lead Generation Representative thrives in a fast-paced environment and is accountable for identifying and qualifying new business opportunities3/10/2015 Lexington, MA Save This Job
Description iRise is seeking a Marketing Coordinator to assist in the execution and measurement of marketing campaigns to enterprise customers that generate qualified sales opportunities and completed sales. RESPONSIBILITIES Participate in the planing and then hands on execution3/10/2015 Los Angeles, CA Save This Job
Description iRise is seeking a hands-on Marketing Manager to plan, execute and measure marketing campaigns to enterprise customers that generate qualified sales opportunities and completed sales. RESPONSIBILITIES Plan and execute compelling demand generation programs to3/10/2015 Los Angeles, CA Save This Job
Are you interested in working for a small, but growing company that has the family feel, but has ample room for career growth? Are you a self-motivated contributor, who finds challenging, complex problems engaging and rewarding to solve? Are you looking for a company that3/10/2015 Burlington, MA Save This Job
Job Details Level Experienced Salary Range Undisclosed Job Location USA-AZ-Scottsdale Travel Percentage None Position Type Full Time Job Shift Day Education Level 2 Year Degree Job Category Information Technology Description POSITION SUMMARY We are looking for an energetic,3/10/2015 Scottsdale, AZ Save This Job
ID 2015-1035 # of Openings 1 Location FirstFuel Posted Date 2/12/2015 Category Sales More information about this job: Overview: FirstFuel is looking for an experienced and diligent self-starter to lead FirstFuel's Sales Operations group. As manager, you will be responsible3/10/2015 Lexington, MA Save This Job
ID 2015-1039 # of Openings 1 Location FirstFuel Posted Date 2/27/2015 Category Marketing More information about this job: Overview: FirstFuel is looking for an ambitious and highly talented individual to join the Marketing & Strategy group. The Marketing Associate will focus3/10/2015 Lexington, MA Save This Job
ABOUT THE ORGANIZATIONWith 100+ office locations across the nation, Paychex produced $2.3 billion in revenue in fiscal 2013. The company offers an ever-growing variety of payroll and human resource products and services that help clients do what they do best - run their business.3/10/2015 Glenview, IL Save This Job
Description Does the digital world excite you? Does data make you want to dig deeper? Do you want to learn more about marketing in a digital world? If you answered yes to all three questions, you might be eMarketer's next intern! We're looking for part-time interns to work in3/9/2015 New York, NY Save This Job
Inside Business Development Representative ? U.S. LOCATION / PORTLAND, OR iovation is in the business of making the internet a safer place. We've spent the last ten years developing award-winning technologies that now stop more than 200,000 fraudulent activities every day for3/9/2015 Portland, OR Save This Job
About the Role At Balihoo, interns are an important part of our team. When you accept an internship with Balihoo you will be supporting projects and delivering services essential to helping Balihoo achieve success. Our job on the Customer Success Team is to set the standard for3/4/2015 Boise, ID Save This Job


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The Karnataka Government has decided to extend the Urban Property Ownership Record (UPOR) project to 10 more cities of the State. The project envisages creation of comprehensive database (spatial and non-spatial) of all properties in cities.
Speaking at a function organised to mark the 15th National Land Survey Day celebrations here, K.S. Prabhakar, Commissioner, Land Survey, said the UPOR, which was under implementation in five cities of the State, would be extended to 10 more cities.
The UPOR was being implemented in Mysore, Mangalore, Hubli-Dharwad, Bellary and Shimoga. The project would clearly demarcate the boundary line and property title of nearly eight lakh property holders in these five cities, he said.
The project would be completed in October end while the new project in 10 cities would commence by December end, Mr. Prabhakar said.
Project cost
The cost incurred for the project in five cities was Rs. 5 crore.
About Rs. 15 crore would be required to take up the project in 10 cities, which would be identified soon, he said.
Being implemented through the public-private partnership (PPP) mode, the project would give a unique identity to the urban properties.
The survey involved the process of locating, identifying, measuring, mapping, collecting documents, and recording details in the property records card.
The UPOR project collected property details such as the coordinates of the boundary points of the land plot; area of the land; building details such as the built-up area and a number of floors; and the rights on the property such as ownership, mortgage, and lease; and history of transaction on the property.
Thus the UPOR certificate — issued by the Department of Survey, Settlement and Land Records — would be a legal document and would be the only valid ownership certificate.
The private partners would be responsible for spatial data creation, and creation of information technology infrastructure and delivery of services.
The Department of Survey, Settlement and Land Records of the Karnataka Government would create spatial records along with the vendor.
Minister for IT/BT and Housing Katta Subramanaya Naidu said the officials should maintain transparency while preparing land records.
Keywords: UPOR, urban property, Department of Survey


text:
Your Letter: Come back to Minnesota, Oberstar
Where is Rep. James Oberstar? He is not on the bike paths of Minnesota. He is not in his small home in Minnesota. He must be in his big home in whatever state he lives in in the northeastern U.S. Maybe he is holding town hall meetings there. He seemed to find time to have meetings when he was running for re-election. Now he seems to be missing in action.
Come back to Minnesota, Jim. We have some questions for you.
Are you a newspaper subscriber but you don't have a Digital Access account yet? https://secure.forumcomm.com/?publisher_ID=40&event=subscriber/lookup.
You will need your subscription account number and phone number. Not sure if you have an account? Email us at email@example.com and we can help you.


text:
Find Us at…
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AboutA web log for all fans of Walt Disney, The Disney Company, and its many products. Using the theories behind Walt Disney's family oriented entertainment and education, this blog is intended to be a safe read for the whole family. Proud to be a part of Quality Will Out Omnimedia. The Disney Blog is not affiliated with The Walt Disney Company in any way. All Disney parks, attractions, lands, shows, event names, etc. are registered trademarks of The Walt Disney Company. The Disney Blog is affiliated with LaughingPlace.com, the number one Disney Fan site on the internet. Please see creative commons license at the bottom of this page for copyright information. All content on this website is my own and does not necessarily represent the views of my employer or anyone else on the planet. The Disney Blog is supported by advertising and some of the links on this site and in product reviews are revenue share affiliate ads. I also do accept product for review and to give away as prizes. However, I compose all my editorial separate from any decision regarding advertising or affiliate links. YMMV.
Tag Archives: pixar animation
New Poster for Pixar's Finding Dory
While wandering through the The Magic of Disney Animation building at Disney's Hollywood Studios I noticed that there was a new poster for Pixar's "Finding Dory." I'm a bit surprised by how dark & murky the feel is. But I … Continue reading
Posted in pixar Tagged finding dory, Finding Nemo, Finding Nemo 2, pixar, pixar animation, pixar animation studios 1 Comment
If Christopher Nolan directed Wall-E, A mashup trailer
When Disney's Big Hero 6 opens on November 7th, it's going to have some big competition from the latest Christopher Nolan film – Interstellar, which opens on the 5th. Pre-saging that encounter a little bit, video mashup artist Bobby Burns … Continue reading
Posted in Animation, pixar Tagged Animation, fan art, fandom, mashup, pixar animation, trailer mashup Comments Off
Brave – Sound Documentary and more Pictures
If you haven't yet seen Pixar's Brave you definitely need to make an effort to get to a theater this weekend and take it in. It's not just the story and characters who are compelling, but it's the beautiful artistry … Continue reading
Posted in pixar Tagged atmos, brave, pixar, pixar animation, sound, surround sound Comments Off
Oil Company renames itself Pixar
After reading a strange press release found by Big Screen Animation blog, I had to double-check the calendar to make sure it wasn't already April Fools day. A Canadian oil company has renamed itself after Pixar Animation Studios, perhaps in … Continue reading
Posted in pixar Tagged big screen animation, emeryville, oil, pixar, pixar animation, pixar studios, trademark 17 Comments


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SEO marketing for Expreciate.com
Closed - This job posting has been filled and work has been completed.
Job Description
White hat methods only. Expreciate.com is a new site and we need SEO help to optimize traffic and increase conversion. Not being able to work face to face is difficult, therefore I need detailed reports weekly that shows progress on the project. We need to be able to communicate through skype as well to allow for better communication. I do try to accommodate for our differing timezones, so I expect the same in return.


text:
Make sure you go there when Sophie B. isn't or else she'll ruin your holliday...
great view and friendly people
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Thomas E Uveges
Eunice Kennedy Shriver National Institute of Child Health and Human Development, Роквилл, Maryland, United States
Are you Thomas E Uveges?
Claim your profile
Total impact
Available from: ncbi.nlm.nih.gov
Alendronate treatment of the brtl osteogenesis imperfecta mouse improves femoral geometry and load response before fracture but decreases predicted material properties and has detrimental effects on osteoblasts and bone formation.
Thomas E Uveges,
Kenneth M Kozloff
Jennifer M Ty
Felicia Ledgard
Cathleen L Raggio
Gloria Gronowicz
Steven A Goldstein
Joan C Marini
[Show abstract]
[Hide abstract]
Long courses of bisphosphonates are widely administered to children with osteogenesis imperfecta (OI), although bisphosphonates do not block mutant collagen secretion and may affect bone matrix composition or structure. The Brtl mouse has a glycine substitution in col1a1 and is ideal for modeling the effects of bisphosphonate in classical OI. We treated Brtl and wildtype mice with alendronate (Aln; 0.219 mg/kg/wk, SC) for 6 or 12 wk and compared treated and untreated femora of both genotypes. Mutant and wildtype bone had similar responses to Aln treatment. Femoral areal BMD and cortical volumetric BMD increased significantly after 12 wk, but femoral length and growth curves were unaltered. Aln improved Brtl diaphyseal cortical thickness and trabecular number after 6 wk and cross-sectional shape after 12 wk. Mechanically, Aln significantly increased stiffness in wildtype femora and load to fracture in both genotypes after 12 wk. However, predicted material strength and elastic modulus were negatively impacted by 12 wk of Aln in both genotypes, and metaphyseal remnants of mineralized cartilage also increased. Brtl femoral brittleness was unimproved. Brtl osteoclast and osteoblast surface were unchanged by treatment. However, decreased mineral apposition rate and bone formation rate/bone surface and the flattened morphology of Brtl osteoblasts suggested that Aln impaired osteoblast function and matrix synthesis. We conclude that Aln treatment improves Brtl femoral geometry and load to fracture but decreases bone matrix synthesis and predicted material modulus and strength, with striking retention of mineralized cartilage. Beneficial and detrimental changes appear concomitantly. Limiting cumulative bisphosphonate exposure of OI bone will minimize detrimental effects.
Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 05/2009; 24(5):849-59. DOI:10.1359/jbmr.081238
· 6.04 Impact Factor
Available from: Clemens Bergwitz
Cellular mechanism of decreased bone in Brtl mouse model of OI: imbalance of decreased osteoblast function and increased osteoclasts and their precursors.
Thomas E Uveges,
Patricia Collin-Osdoby
Wayne A Cabral
Felicia Ledgard
Leah Goldberg
Clemens Bergwitz
Antonella Forlino
Philip Osdoby
Gloria A Gronowicz
Joan C Marini
[Show abstract]
[Hide abstract]
The Brtl mouse, a knock-in model for moderately severe osteogenesis imperfecta (OI), has a G349C substitution in half of type I collagen alpha1(I) chains. We studied the cellular contribution to Brtl bone properties. Brtl cortical and trabecular bone are reduced before and after puberty, with BV/TV decreased 40-45%. Brtl ObS/BS is comparable to wildtype, and Brtl and wildtype marrow generate equivalent number of colony-forming units (CFUs) at both ages. However, OcS/BS is increased in Brtl at both ages (36-45%), as are TRACP(+) cell numbers (57-47%). After puberty, Brtl ObS/BS decreases comparably to wildtype mice, but osteoblast matrix production (MAR) decreases to one half of wildtype values. In contrast, Brtl OcS falls only moderately (approximately 16%), and Brtl TRACP staining remains significantly elevated compared with wildtype. Consequently, Brtl BFR decreases from normal at 2 mo to one half of wildtype values at 6 mo. Immunohistochemistry and real-time RT-PCR show increased RANK, RANKL, and osteoprotegerin (OPG) levels in Brtl, although a normal RANKL/OPG ratio is maintained. TRACP(+) precursors are markedly elevated in Brtl marrow cultures and form more osteoclasts, suggesting that osteoclast increases arise from more RANK-expressing precursors. We conclude that osteoblasts and osteoclasts are unsynchronized in Brtl bone. This cellular imbalance results in declining BFR as Brtl ages, consistent with reduced femoral geometry. The disparity in cellular number and function results from poorly functioning osteoblasts in addition to increased RANK-expressing precursors that respond to normal RANKL/OPG ratios to generate more bone-resorbing osteoclasts. Interruption of the stimulus that increases osteoclast precursors may lead to novel OI therapies.
Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 09/2008; 23(12):1983-94. DOI:10.1359/jbmr.080804
· 6.04 Impact Factor
Brief report: Deficiency of cartilage-associated protein in recessive lethal osteogenesis imperfecta
Aileen M Barnes
Weizhong Chang
Roy Morello
Wayne A Cabral
MaryAnn Weis
David R Eyre
Sergey Leikin
Elena Makareeva
Natalia Kuznetsova
, Thomas E Uveges,
Aarthi Ashok
Armando W Flor
John J Mulvihill
Patrick L Wilson
Usha T Sundaram
Brendan Lee
Joan C Marini
[Show abstract]
[Hide abstract]
Classic osteogenesis imperfecta, an autosomal dominant disorder associated with osteoporosis and bone fragility, is caused by mutations in the genes for type I collagen. A recessive form of the disorder has long been suspected. Since the loss of cartilage-associated protein (CRTAP), which is required for post-translational prolyl 3-hydroxylation of collagen, causes severe osteoporosis in mice, we investigated whether CRTAP deficiency is associated with recessive osteogenesis imperfecta. Three of 10 children with lethal or severe osteogenesis imperfecta, who did not have a primary collagen defect yet had excess post-translational modification of collagen, were found to have a recessive condition resulting in CRTAP deficiency, suggesting that prolyl 3-hydroxylation of type I collagen is important for bone formation.
New England Journal of Medicine 01/2007; 355(26):2757-64. DOI:10.1056/NEJMoa063804
· 54.42 Impact Factor
Brtl/Mov13 mice have a milder OI phenotype than Brtl/+mice
T. E. Uveges,
J. A. Meganck
E. L. Daley
S. A. Goldstein
J. C. Marini
Matrix Biology 11/2006; 25. DOI:10.1016/j.matbio.2006.08.169
· 3.65 Impact Factor
Available from: Matthew R Allen
Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to osteoporosis.
Yasuo Miura
Masako Miura
Stan Gronthos
Matthew R Allen
Chunzhang Cao
, Thomas E Uveges,
Yanming Bi
Driss Ehirchiou
Angela Kortesidis
Songtao Shi
Li Zhang
[Show abstract]
[Hide abstract]
Osteogenesis by the bone marrow stromal stem cells (BMSSCs) supports continuous bone formation and the homeostasis of the bone marrow microenvironment. The mechanism that controls the proliferation and differentiation of BMSSCs is not fully understood. Here, we report that CD18, a surface protein present primarily on hematopoietic cells, but not on differentiated mesenchymal cells, is expressed by the stromal stem cells and plays a critical role in the osteogenic process. Constitutive expression of CD18 on BMSSCs using a retroviral promoter significantly enhances bone formation in vivo, whereas genetic inactivation of CD18 in mice leads to defective osteogenesis due to decreased expression of the osteogenic master regulator Runx2/Cbfa1. The defective osteogenesis of the CD18-null BMSSCs can be restored by expressing full-length, but not cytoplasmic domain-truncated, CD18. Radiographic analyses with dual-energy x-ray absorptiometry and 3D microcomputed tomography show that mice lacking CD18 have decreased bone mineral density and exhibit certain features of osteoporosis. Altogether, this work demonstrates that CD18 functions critically in the osteogenesis of BMSSCs, and thus lack of CD18 expression in the leukocyte adhesion deficiency patients may predispose them to osteoporosis.
Proceedings of the National Academy of Sciences 10/2005; 102(39):14022-7. DOI:10.1073/pnas.0409397102
· 9.81 Impact Factor
Available from: Clemens Bergwitz
Brittle IV mouse model for osteogenesis imperfecta IV demonstrates postpubertal adaptations to improve whole bone strength.
Kenneth M Kozloff
Angela Carden
Clemens Bergwitz
Antonella Forlino
, Thomas E Uveges,
Michael D Morris
Joan C Marini
Steven A Goldstein
[Show abstract]
[Hide abstract]
The Brtl mouse model for type IV osteogenesis imperfecta improves its whole bone strength and stiffness between 2 and 6 months of age. This adaptation is accomplished without a corresponding improvement in geometric resistance to bending, suggesting an improvement in matrix material properties. The Brittle IV (Brtl) mouse was developed as a knock-in model for osteogenesis imperfecta (OI) type IV. A Gly349Cys substitution was introduced into one col1a1 allele, resulting in a phenotype representative of the disease. In this study, we investigate the effect of the Brtl mutation on whole bone architecture, strength, and composition across a range of age groups. One-, 2-, 6-, and 12-month-old Brtl and wildtype (WT) mice were analyzed. Femurs were assessed at the central diaphysis for cortical geometric parameters using microCT and were subsequently mechanically tested to failure by four-point bending. Matrix material properties were predicted using microCT data to normalize data from mechanical tests. Raman spectroscopy and DXA were used to assess matrix composition. Our findings show a postpubertal adaptation in which Brtl femoral strength and stiffness increase through a mechanism independent of changes in whole bone geometry. These findings suggest an improvement in the material properties of the bone matrix itself, rather than improvements in whole bone geometry, as seen in previous mouse models of OI. Raman spectroscopic results suggest these findings may be caused by changes in mineral/matrix balance rather than improvements in mineral crystallinity. Our findings parallel the currently unexplained clinical observation of decreased fractures in human OI patients after puberty. The Brtl mouse remains an important tool for investigating therapeutic interventions for OI.
Journal of Bone and Mineral Research 05/2004; 19(4):614-22. DOI:10.1359/JBMR.040111
· 6.59 Impact Factor
Available from: Linda M Parysek
Intron 1 is required for cell type-specific, but not injury-responsive, peripherin gene expression.
Thomas E Uveges,
Yuqing Shan
Bridget E Kramer
David C Wight
Linda M Parysek
[Show abstract]
[Hide abstract]
The "primitive" neurons of the peripheral nervous system (PNS) have the remarkable ability to regenerate new fibers. This regenerative process requires a sequence of gene activation and repression that is poorly understood. One gene that is almost exclusively expressed in neurons of the PNS and is activated after nerve injury is the peripherin intermediate filament gene, but little is known about the genomic elements that control either its restricted expression or its response to nerve injury in adult mice. Previous studies suggested that both 5' flanking sequence and intragenic regions were required for cell type-specific and injury-specific expression. To determine which intragenic regions were critical, mice were generated that expressed peripherin transgenes lacking different introns. Analyses of these mice revealed that deletion of introns 2-8 had no effect on either the cell type-specific or injury-specific expression of the peripherin gene; however, the remaining intron, intron 1, differentially bound Sp1 transcription-related proteins/protein complexes in extracts from peripherin-expressing and nonexpressing tissues. Furthermore, a transgene that lacked intron 1 was not expressed in many neurons that contain endogenous peripherin but was activated after injury. Thus, accurate cell type-specific peripherin gene expression in the PNS depends on elements within intron 1, but other sequences, most likely in the 5'flanking region, are required for activating the peripherin gene in response to nerve injury.
The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 10/2002; 22(18):7959-67.
· 6.75 Impact Factor
The role of intron 1 in peripherin gene expression [electronic resource] /
Thomas. Uveges,
OhioLINK Electronic Theses and Dissertations Center
[Show abstract]
[Hide abstract]
The goal of my thesis was to gain an understanding of how the Type III intermediate filament (IF) gene peripherin is expressed in a cell type-specific manner and activated in response to nerve injury. The peripherin gene is expressed almost exclusively in neurons of the peripheral nervous system (PNS) that have the ability to regenerate. Previous studies suggested that both 5' flanking sequence and intragenic regions were required for cell type-specific and injury-specific expression (Belecky-Adams et al ., 1993). My worked focused how the intragenic regions of the peripherin gene are controlling gene expression. To determine the intragenic regions that are critical for regulating peripherin gene expression, transgenic mice were generated that expressed peripherin transgenes lacking different introns. Analyses of these mice revealed that deletion of introns 2 through 8 had no effect on either the cell type-specific or injury-specific expression of the peripherin gene. Further, a transgene lacking intron 1 did not display accurate cell type-specific expression, but was activated after injury. Thus, accurate cell type-specific peripherin gene expression depends on elements within intron 1, but other sequences, most likely in the 5'flanking region, are required for activating the peripherin gene in response to nerve injury. Activation of the peripherin gene after nerve injury suggests that the peripherin proteins may have critical functions during nerve re-growth. Studies to determine the function of the peripherin IF network in the formation of neurite in vitro showed that an intact peripherin network is essential for maintenance/formation of long-branch neurite trees and for normal mitochondrial distribution. Text (abstract in HTML; full text in PDF). System requirements: Macintosh or IBM PC-compatible computer; World Wide Web browser; Adobe Acrobat Reader. Mode of access: World Wide Web. Title from electronic thesis title page (viewed Oct. 3, 2002). Thesis (Ph. D.)--University of Cincinnati, 2002. Includes bibliographical references. Includes abstract.
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Carolina Marini
Azienda Ospedaliero-Universitaria Pisana
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Wayne A Cabral
U.S. Department of Health and Human Services
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Yale University
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University of Southern California
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text:
Moditen - General Information:Moditen is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Moditen exists as small alkaline deliquescent crystals with a saline taste.
Moditen was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful.
Moditen was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic action. Their mode of action is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism.
Drugs categories
Other Brand Names containing Piperazine
Moditen - Pharmacology:
Moditen is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.
Moditen for patients
Data is temporarily not available
Moditen Interactions
Phenothiazines - Taking piperazine and a phenothiazine together may increase the risk of convulsions (seizures).
Pyrantel (e.g., Antiminth) - Taking piperazine and pyrantel together may decrease the effects of piperazine.
Moditen Contraindications
Patients with hypersensitivity to piperazine salts or a history of renal function impairment should avoid this medication
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..


text:
Sophie C Burce (1914 - 2008)
Biography & Family History Add details
Sophie C Burce (1914 - 2008) was born on November 28, 1914. She was born into the Burce family.
She died on June 19, 2008 at 93 years old.
Sophie C Burce's last known residence is at Crystal Lake, McHenry County, Illinois.
The data on this page comes from the official record for Sophie C Burce in the SSDI (United States Social Security Master Death Index). What is the SSDI?
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Our new devotional "If God Loves Me, Why Did I Lose My Job?" explores the struggle of unemployment. Sign up here.
+ A Gershonite Levite, son of Jahath. (1 Chronicles 6:20) (B.C. after 1706.)
+ Another Gershonite, son of Shimei, (1 Chronicles 6:42) possibly the same as the preceding.
+ Father of ancestor of Joab, a Gershonite in the reign of Hezekiah. (2 Chronicles 29:12) (B.C. before 726.) At a much earlier period we find the same collocation of names, Zimmah and Joah as father and son. (1 Chronicles 6:20)


text:
Winnipeg Free Press - PRINT EDITION
He's on a mission to promote U.K. ties
Consul general urges Manitoba to look overseas
The United Kingdom is hoping Manitoba can help it battle through the effects of a struggling global economy.
Tony Kay, newly appointed British consul general for the Prairie provinces, believes Manitoba can help fill some of the void created by troubled economies in Greece and Italy.
"There's no doubt that the U.K. economy has been affected by what's going on in the euro zone, but we have a plan. Part of that is to encourage and actively promote British companies to export to overseas markets," he said Tuesday during an interview at the Winnipeg Free Press News Café.
"We're trying to grow our way out of the difficulties that we and others have had over the past couple of years with the global economic downturn."
Kay, who is based in Calgary, and his team of five aren't here to sign any deals this week, but they're hoping to lay the groundwork for a flurry of them in the not-too-distant future.
"We look at the Prairie provinces as a place where Britain could do a lot of really cool stuff, whether on the trade, investment, science and technology, or cultural sides," he said.
For example, he said Britain is trying to encourage foreign companies to set up shop in England, Scotland, Northern Ireland and Wales.
Kay met with members of Manitoba's life sciences, digital media, information, communication and technology sectors on Monday. On Tuesday night, the British contingent was networking with 100 "of the great and the good" from Manitoba industry and government.
"I've been struck with how dynamic, young, fresh and innovative people and organizations in this province are," Kay said. "It doesn't take someone like me to tell them they should be exploring opportunities overseas. It's in their DNA. I'd like them to be thinking about the U.K. when they're reaching out to those foreign markets," Kay said.
Even though Canada and the U.K. have an "extremely strong" trading relationship in both directions, Kay said part of his challenge is increasing awareness about Manitoba back home.
"Frankly, I don't think enough people know about (Manitoba) in the U.K. and Europe. I see my role not just to promote the U.K. in Manitoba but to help Manitoba promote itself to foreign markets. I don't think Manitoba should be shy," he said.
Kay wasn't about to complain about the bone-chilling temperatures in Winnipeg this week.
"It's not actually that cold inside; when you go outside, it is a bit chilly. I thought it would be a good idea to come here in what is statistically the coldest week of the year to demonstrate Britain's commitment to Manitoba is really strong and positive and not dictated by the fair weather," he said.
Republished from the Winnipeg Free Press print edition January 23, 2013 B4
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Showing 221 - 240 of 250
The John Calvin pumpkin
We've resurrected the John Calvin pumpkin! Download the template, and carve your own Reformer.
October 29, 2010 | Myrna Anderson
The king, his ring and the temple
A professor and student of classics are researching an ancient Greek text about Solomon and magic.
July 15, 2011 | Jeff Febus , Andrew Knot
The Nazi Titanic
"British and American bombers [were] coming over day and night, the Stalingrad defeat [was] clear to everybody. So the film just [didn't] look propagandistically good."
April 23, 2012 | Matt Kucinski
The Visiting Scholars program
Scholars from many disciplines and many countries make Calvin a research home away from home.
February 15, 2012 | Madeline Tracy
The world from a sailboat
Two sisters, a Calvin sophomore and junior, spent a year circumnavigating the globe with their family.
November 08, 2010 | Amy Surbatovich
To China—with the help of a Gilman
Cottingham, an information systems major and Chinese language minor, recently landed a $4,500 scholarship from the Benjamin A. Gilman Foundation to fund his China studies
August 15, 2008 | Myrna Anderson
Two Fulbrights, two continents
Johnathan Bascom will spend his Fulbright year in Ethiopia, and Corwin Smidt will spend his in The Netherlands.
April 07, 2011 | Myrna Anderson
Two Goldwaters, two NSF fellowships
Four Calvin science students have landed prestigious research awards.
April 05, 2012 | Myrna Anderson
U.S. News gives Calvin high marks
U.S. News & World Report gives Calvin high marks for its strong commitment to teaching and service-learning and for the quality of its first-year experience.
September 20, 2012 | Matt Kucinski
Unlearn Week
Unlearn Week kicks off a yearlong conversation about anti-racism.
October 10, 2011 | Myrna Anderson
Unlearn Week
This year, Unlearn Week, held from October 4 through 9, includes events about the Obama Administration, cross-racial adoption and the Asian experience.
October 05, 2009 | Myrna Anderson
Unlearn Week 2012
This year's week of anti-racism programming features speakers, discussions, a movie and a food festival.
October 05, 2012 | Myrna Anderson
Van Liere lands prestigious fellowship
To understand the medieval Christian fascination with the Hebrew Bible, Frans van Liere will study where Einstein studied.
February 24, 2012 | Myrna Anderson
Video: A view of science research
This summer nearly 90 science students researched everything from the human eye to herring gulls. Watch the video.
October 14, 2011 | Matt Kucinski
We Are Calvin: Adam Wiersma
This summer, Calvin students are keeping us informed on where they are and what they're doing—from working the Google HelpDesk in Seattle to engineering a bridge in Kenya.
July 30, 2013 | Matt Kucinski
We Are Calvin: Andrew Mitchell
This summer, Calvin students are keeping us informed on where they are and what they're doing—from working the Google HelpDesk in Seattle to engineering a bridge in Kenya.
June 06, 2013 | Matt Kucinski
We Are Calvin: Andrew Pruim
Sophomore Andrew Pruim spent the month of January in the German Interim Abroad program. He learned more about the German language and culture and did a little dancing too.
February 12, 2014 | Matt Kucinski
We Are Calvin: Corrin Timmer
Senior Corrin Timmer spent this spring on Calvin's Washington D.C. semester as an events intern for United Nations Relief Works Agency USA.
May 19, 2014 | Matt Kucinski
We Are Calvin: Eric Seo
Sophomore Eric Seo is spending this Spring in the semester abroad program in York, England.
April 03, 2014 | Matt Kucinski
We Are Calvin: Grace Liao
Junior Grace Liao spent this summer in Taiwan building relationships and sharing the gospel.
September 03, 2013 | Matt Kucinski


text:
Minnesota man stateside after 9 months in UAE prison
MINNEAPOLIS — A Minnesota man who spent nine months in a United Arab Emirates prison for making a spoof video landed on U.S. soil Thursday after being freed this week.
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comingsoon.net – As Thor 2 gears up for production, the search is now to replace Joshua Dallas, who played Fandral, one of the Warriors Three, in the 2011 original. EW reports that, due to the actor's commitments to ABC's "Once Upon a Time", the role will be recast.
Created by jetli 2 years 41 weeks ago
About jetli
Don't let the lower case letterings in his name fool you. He's quick and deadly with the headlines and he's always on target. His delivery could use more work though.
Box Office
1. Divergent Series: Insurgent, TheGross: $52,263,680Total: $52,263,680
2. CinderellaGross: $34,967,659Total: $122,516,793
3. Run All NightGross: $5,032,323Total: $19,639,211
4. Gunman, TheGross: $5,028,702Total: $5,028,702
Gross: $4,627,340Total: $114,597,783


text: Greg T Kisses Cabbie [Video] By Chadwick July 4, 2012 8:08 AM Share on Facebook Share on Twitter I'm not positive that this is a real holiday but Greg T celebrates Kiss a Cabbie day back in March. I don't think the Cabbies are down with it. Filed Under: greg t Category: Elvis Duran Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of 96.7 KISS FM Recommended For You Around the Web


text:
3,022 news items
asparaWIIgus said:
Ninjas pwn pirates so much.
Nova said:
I hope capcom does a better job with textures. I don't really see the point of this game. Is it an action adventure? Or what?
Step said:
Yeah, the pirates would never even know what hit them. Also, anything with skyboarding, and mentions of pirates and ninjas, is either TOTALLY AWESOME or completely pandering and lame. Hope it's the first one.
Anon said:
What?! Apparently Bionic Games dmca-ed all these videos. Here I am, a potential customer, wanting to view a commercial that somebody created for their game free of charge, and I can't because of copyright. Way to ruin your own business, Bionic Games, I'll go buy games from somebody else.
Wii's World said:
It may be because they ended up going with a completely different art style than what was shown in these early videos.
Project Ukulele - Possible Hint at Characters
Could it be?
Free to Play Pokemon Shuffle now available on 3DS eShop
Nintendo offers another micro-transaction based title
Gold Mario Amiibo is a Wal-Mart Exclusive
Get ready to shell out your coins
Area Effect Announces Izle for Wii U
Part action, part adventure, all cel-shaded
Nintendo Confirmed As Sponsor For APEX 2015
Another positive step for the Smash competitive scene
Majora's Mask 3D Collector's Edition Contains Skull Kid Figurine
Pre-orders are now open!
Ackk Studios Rings in the New Year with New Y2K footage
Starting the New Year with a bang!
Is Nintendo Making A New Wii U Gamepad?
Recent commercial may have leaked new GamePad model
Zeldathon Relief Announced
Pot smashing for a great cause
Why the Inclusion of The Duck Hunt Dog in Super Smash Bros. Was Brilliant
How the the most hated character in video games rose to the top of the Smash heap
Michael Jordan said:
No they're making it from the movie ... Speed Racer: The Video Game
daveoneal said:
Thanks Rob. I had no idea this one was published. I'm very happy about it! Yes, Jonathan, it is hard as all get-out, ... Street Fighter 2010: The Final Fight review
daveoneal said:
This was a very well-written review. Apparently Super Hexagon was developed by Terry Cavanagh (who made vvvvvv), so ... Cosmophony review
dirk said:
:p p ... TMNT: Smash Up
dirk said:
cool :p ... TMNT: Smash Up
Wii's World is not officially affiliated with Nintendo! (but they wish we were).


text:
- •Applications•Where it's
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Tags: Astrophysics, Black hole physics, Galaxy Astrophysics, Gravitational waves, High Energy Astrophysical Phenomena, N-body simulation, nVidia, nVidia GeForce 9800 GX2, nVidia GeForce GTX 280, nVidia GeForce GTX 285, Solar and Stellar Astrophysics, Stellar dynamics
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- An efficient solution for hazardous geophysical flows simulation using GPUs
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- FastTree: A Hardware KD-Tree Construction Acceleration Engine for Real-Time Ray Tracing
- MILJS: Brand New JavaScript Libraries for Matrix Calculation and Machine Learning
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Exploiting Space and Time Coherence in Grid-based Sorting
NMF-mGPU: non-negative matrix factorization on multi-GPU systems
Pseudorandom Numbers Generation for Monte Carlo Simulations on GPUs: OpenCL Approach
Data driven scheduling approach for the multi-node multi-GPU Cholesky decomposition
Arioc: high-throughput read alignment with GPU-accelerated exploration of the seed-and-extend search space
On learning optimized reaction diffusion processes for effective image restoration
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