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CD fridge - are french doors better than single door for space?
I would like to hear your thoughts.
My space is small - 13.6 x 10 kitchen - going from peninsula to U shape with small 4x3 island.
Still debating that since clearance can be at the min 36".
We are a family of 3 and I am not a big fan of huge bulky fridges.
I was looking the Fisher Paykel CD 33" with one door and bottom freezer but now thinking if a CD french door will give me more room with that small of a clearance.
Just having trouble picking the right 36" french door fridge not breaking my budget ( $2.5 ) and also looking sleek and elegant.
Please share your advice -- thank you!
We had an Amana CD bottom freezer drawer for about 10 years. Not FD.
Liked it fine.
Had to replace in December, now have KA Architect series CD fridge with bottom freezer drawer and FD.
So the same size fridge, only difference is the doors.
I don't notice that there is more room when the door is open. I DO notice that now I have to juggle 2 doors instead of just 1.
So as long as you have room to open the doors fully enough to open the crisper drawers, I wouldn't say one is better or worse then the other.
BTW, ours was $1999 at sears. Link below. Maybe this will work for you.
Here is a link that might be useful: KA counter depth fridge
I am currently deciding what frig to go with in a narrow galley. I need to look at a few more but I think I will be going with a freezerless model. There are several available and are about counter depth with more room. We do have additional freezer space available, so this is very doable for us.
I am not a fan of french door or double doors as you always need two arms to open the fridge and end up propping it open with your feet while awkwardly trying to place your tray or dish. I find single door counter depth the best to give you a wide open view of the space with not too deep recesses to lose leftover boxes or grow science experiments. I also prefer bottom freezer models.


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Mystery! 1980 | TV Show Watchlist
Whodunits, courtroom dramas and suspense tales make up this often brilliant anthology. It features adaptations of tales by myriad classic mystery writers, from Arthur Conan Doyle and Agatha Christie to Dick Francis and John Mortimer, with such notable figu (more…)
Premiered: February 5, 1980
Rating: TV-PG
Season 11, Episode 31 Inspector Morse: Deceived by Flight
First Aired: May 30, 1991
Chief Insp. Morse (John Thaw) probes the death of his former Oxford roommate in Part 1 of the two-part "Deceived by Flight." Donn: Daniel Massey. Kate: Sharon Maughan. Marshall: Norman Rodway. Cranston: Nicky Henson.
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Norman Rodway Norman Rodway Marshall
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Super Hotel Inn Ikebukuro-Eki Kitaguchi
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I've Got My Dance Pants On
... I have enjoyed the company of all of the Japanese students I have met and hope to keep in contact with them once I am back in the United States.
During the farewell party the students put on their robes and did a final dance for everyone. Then some of us joined in and they let us wear their robes that they hand painted.
What a gosh darn honor.
Tour of Tokyo
... went to a matcha tea ceremony at a garden that had bonsai trees that were hundreds of years old. Lunch at the hotel where the food was cooked on hot stone plates made from the lava of Mt Fuji. Then a boat ride which passed under 12 bridges (I previously had no idea how many waterways run through Tokyo.) The boat ride took us to a very cool shopping arcade on Nakamise street. There were large gates at one ...
Day 3
... br> I did find the train station and charged my train card, maybe tomorrow I will get a little braver and take a train ride somewhere. The cool thing about finding the train station is I found all the shops inside the station! The other side of the station produced even more shops in every direction and I was unsure where to start! I have never seen so many stores ...
"At least we didn't need the slides!"
... traces of peanuts and cashews"! Ok, no problem...except that the guys are on the other side of the plane, I have the food bag and the food carts are in both isles. I eventually get up to pass the food bag because I have a sunbutter and jelly sandwich in there. Later, at another meal, I have a stranger pass me a note like in grade-school "Please pass to seat 34L- Are water chestnuts nuts? -Joe"
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The Science Museum
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Please help me identify this pill
white,oval pill (V on one side, &35/98 other side)
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Are you Fanya Zeng?Claim your profile
Publications (25)156.81 Total impact
Article: Characterisation of animal angiotensin-converting enzyme 2 receptors and use of pseudotyped virus to correlate receptor binding with susceptibility of SARS-CoV infection.Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 08/2012; 18 Suppl 3:35-8.
[Show abstract] [Hide abstract]
ABSTRACT: Although membrane perforation was suggested as the means of penetration mediated by IBDV, the cellular mechanism being hijacked to facilitate its entry is largely unknown. In this study, the entry pathway of cell culture adapted IBDV (caIBDV) was characterized in DF-1 chicken embryonic fibroblasts. We observed that the entry of caIBDV was inhibited by bafilomycin A1 and CaEGTA which interfere with the function of vacuolar H(+)-ATPase (V-ATPase) and retain endosomal Ca(2+). This result suggests that the intact caIBDV particle was transported to the V-ATPase positive vesicles for uncoating and implicates an essential role of endocytosis during the viral entry. The IBDV-mediated endocytosis was demonstrated to be clathrin-independent. Instead, the entry of caIBDV in DF-1 was reduced under the inhibitions or depletions of lipid raft, c-Src tyrosine kinase, dynamin and actin polymerization. In summary, this study confirmed the role of endocytosis in caIBDV entry and characterized the route of its endocytosis.Virus Research 12/2011; 165(1):9-16. DOI:10.1016/j.virusres.2011.12.016 · 2.83 Impact Factor
Article: Phylogenetic perspectives on the epidemiology and origins of SARS and SARS-like coronaviruses[Show abstract] [Hide abstract]
ABSTRACT: Severe Acute Respiratory Syndrome (SARS) is a respiratory disease caused by a zoonotic coronavirus (CoV) named SARS-CoV (SCoV), which rapidly swept the globe after its emergence in rural China during late 2002. The origins of SCoV have been mysterious and controversial, until the recent discovery of SARS-like CoV (SLCoV) in bats and the proposal of bats as the natural reservior of the Coronaviridae family. In this article, we focused on discussing how phylogenetics contributed to our understanding towards the emergence and transmission of SCoV. We first reviewed the epidemiology of SCoV from a phylogenetic perspective and discussed the controversies over its phylogenetic origins. Then, we summarized the phylogenetic findings in relation to its zoonotic origins and the proposed inter-species viral transmission events. Finally, we also discussed how the discoveries of SCoV and SLCoV expanded our knowledge on the evolution of the Coronaviridae family as well as its implications on the possible future re-emergence of SCoV.Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases 09/2009; 9(6):1185-96. DOI:10.1016/j.meegid.2009.09.015 · 3.22 Impact Factor
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ABSTRACT: Birnaviruses are bi-segmented double-stranded RNA (dsRNA) viruses infecting insects, avian species and a wide range of aquatic species. Although homologous recombination is a common phenomenon in positive-sense RNA viruses, recombination in dsRNA viruses is rarely reported. Here we performed a comprehensive survey on homologous recombination in all available sequences (>1800) of the family Birnaviridae based on phylogenetic incongruence. Although inter-species recombination was not evident, potential intra-species recombination events were detected in aquabirnaviruses and infectious bursal disease virus (IBDV). Eight potential recombination events were identified and the possibility that these events were non-naturally occurring was assessed case by case. Five of the eight events were identified in IBDVs and all of these five events involved live attenuated vaccine strains. This finding suggests that homologous recombination between vaccine and wild-type IBDV strains may have occurred; the potential risk of mass vaccination using live vaccines is discussed. This is the first report of evidence for homologous recombination within the family Birnaviridae.Journal of General Virology 01/2009; 89(Pt 12):3156-64. DOI:10.1099/vir.0.2008/004101-0 · 3.53 Impact Factor
Article: SARS coronavirus and apoptosis.[Show abstract] [Hide abstract]
ABSTRACT: 1. The adenovirus-mediated overexpression of SARS coronavirus (SARS-CoV) spike protein (S) and its C-terminal domain (S2) induce apoptosis in Vero E6 cells. 2. Such apoptosis in Vero E6 cells is time- and dose-dependent. 3. The adenovirus-mediated overexpression of SARS-CoV N-terminal domain (S1) and other structural proteins, including E,M and N protein, do not induce apoptosis.Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 08/2008; 14 Suppl 4:8-13.
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ABSTRACT: In this study, the full mitochondrial genome of a basidiomycete fungus, Pleurotus ostreatus, was sequenced and analyzed. It is a circular DNA molecule of 73 242 bp and contains 44 known genes encoding 18 proteins and 26 RNA genes. The protein-coding genes include 14 common mitochondrial genes, one ribosomal small subunit protein 3 gene, one RNA polymerase gene and two DNA polymerase genes. In addition, one RNA and one DNA polymerase genes were identified in a mitochondrial plasmid. These two genes show relatively low similarities to their homologs in the mitochondrial genome but they are nearly identical to the known mitochondrial plasmid genes from another Pleurotus ostreatus strain. This suggests that the plasmid may mediate the horizontal gene transfer of the DNA and RNA polymerase genes into mitochondrial genome, and such a transfer may be an ancient event. Phylogenetic analysis based on the cox1 ORFs verified the traditional classification of Pleurotus ostreatus among fungi. However, the discordances were observed in the phylogenetic trees based on the six cox1 intronic ORFs of Pleurotus ostreatus and their homologs in other species, suggesting that these intronic ORFs are foreign DNA sequences obtained through HGT. In summary, this analysis provides valuable information towards the understanding of the evolution of fungal mtDNA.FEMS Microbiology Letters 04/2008; 280(1):34-41. DOI:10.1111/j.1574-6968.2007.01048.x · 2.72 Impact Factor
Article: Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: insights on viral regulation of apoptosis and proliferation.[Show abstract] [Hide abstract]
ABSTRACT: We have previously demonstrated that over-expression of spike protein (S) of severe acute respiratory syndrome coronavirus (SARS-CoV) or its C-terminal subunit (S2) is sufficient to induce apoptosis in vitro. To further investigate the possible roles of S2 in SARS-CoV-induced apoptosis and pathogenesis of SARS, we characterized the host expression profiles induced upon S2 over-expression in Vero E6 cells by oligonucleotide microarray analysis. Possible activation of mitochondrial apoptotic pathway in S2 expressing cells was suggested, as evidenced by the up-regulation of cytochrome c and down-regulation of the Bcl-2 family anti-apoptotic members. Inhibition of Bcl-2-related anti-apoptotic pathway was further supported by the diminution of S2-induced apoptosis in Vero E6 cells over-expressing Bcl-xL. In addition, modulation of CCN E2 and CDKN 1A implied the possible control of cell cycle arrest at G1/S phase. This study is expected to extend our understanding on the pathogenesis of SARS at a molecular level.Virology 03/2008; 371(1):32-43. DOI:10.1016/j.virol.2007.09.016 · 3.28 Impact Factor
Article: Evolutionary analyses of European H1N2 swine influenza A virus by placing timestamps on the multiple reassortment events.[Show abstract] [Hide abstract]
ABSTRACT: A novel H1N2 swine influenza A virus emerged in Europe since 1994. Previous phylogenetic analyses revealed that its genome segments were derived from H1N1 human virus, H3N2 human virus and avian-like H1N1/H3N2 swine virus, indicating the possibility of multiple reassortments events. However, dates of these reassortment events have not been investigated systematically. In this study, we used both global and local molecular clock concepts in a maximum likelihood framework to extrapolate the times of origins of the genome segments in European H1N2 swine viruses, and deduced that novel neuraminidase, hemagglutinin and other internal protein genes were introduced to the European H1N2 lineage at the 1970s, early 1980s and late 1980s, respectively through reassortments. Furthermore, in light of the evolutionary timescale reconstructed for the H1N2 viruses, we argue that further reassortments, in addition to those responsible for the introductions of novel genome segments, might have also occurred among the viruses prior to the outbreaks arose in United Kingdom at 1994. Our results confirm that the viral genes of various origins have stably maintained in swine population for many years before the multiple genetic reassortant was detected. Our evolutionary analyses also suggested that the HA and NA genes evolved in a significantly higher rate of synonymous substitutions after they were introduced from human to swine and established the European H1N2 swine lineage.Virus Research 03/2008; 131(2):271-8. DOI:10.1016/j.virusres.2007.08.012 · 2.83 Impact Factor
Article: Evidence of the recombinant origin of a bat severe acute respiratory syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirus.[Show abstract] [Hide abstract]
ABSTRACT: Bats have been identified as the natural reservoir of severe acute respiratory syndrome (SARS)-like and SARS coronaviruses (SLCoV and SCoV). However, previous studies suggested that none of the currently sampled bat SLCoVs is the descendant of the direct ancestor of SCoV, based on their relatively distant phylogenetic relationship. In this study, evidence of the recombinant origin of the genome of a bat SLCoV is demonstrated. We identified a potential recombination breakpoint immediately after the consensus intergenic sequence between open reading frame 1 and the S coding region, suggesting the replication intermediates may participate in the recombination event, as previously speculated for other CoVs. Phylogenetic analysis of its parental regions suggests the presence of an uncharacterized SLCoV lineage that is phylogenetically closer to SCoVs than any of the currently sampled bat SLCoVs. Using various Bayesian molecular-clock models, interspecies transfer of this SLCoV lineage from bats to the amplifying host (e.g., civets) was estimated to have happened a median of 4.08 years before the SARS outbreak. Based on this relatively short window period, we speculate that this uncharacterized SLCoV lineage may contain the direct ancestor of SCoV. This study sheds light on the possible host bat species of the direct ancestor of SCoV, providing valuable information on the scope and focus of surveillance for the origin of SCoV.Journal of Virology 03/2008; 82(4):1819-26. DOI:10.1128/JVI.01926-07 · 4.65 Impact Factor
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ABSTRACT: H5N1 highly pathogenic avian influenza (HPAI) viruses have seriously affected the Asian poultry industry since their recurrence in 2003. The viruses pose a threat of emergence of a global pandemic influenza through point mutation or reassortment leading to a strain that can effectively transmit among humans. In this study, we present phylogenetic evidences for the interlineage reassortment among H5N1 HPAI viruses isolated from humans, cats, and birds in Indonesia, and identify the potential genetic parents of the reassorted genome segments. Parsimony analyses of viral phylogeography suggest that the reassortant viruses may have originated from greater Jakarta and surroundings, and subsequently spread to other regions in the West Java province. In addition, Bayesian methods were used to elucidate the genetic diversity dynamics of the reassortant strain and one of its genetic parents, which revealed a more rapid initial growth of genetic diversity in the reassortant viruses relative to their genetic parent. These results demonstrate that interlineage exchange of genetic information may play a pivotal role in determining viral genetic diversity in a focal population. Moreover, our study also revealed significantly stronger diversifying selection on the M1 and PB2 genes in the lineages preceding and subsequent to the emergence of the reassortant viruses, respectively. We discuss how the corresponding mutations might drive the adaptation and onward transmission of the newly formed reassortant viruses.PLoS Pathogens 02/2008; 4(8):e1000130. DOI:10.1371/journal.ppat.1000130 · 8.06 Impact Factor
Veterinary Microbiology 02/2008; 126(4):390-3. DOI:10.1016/j.vetmic.2007.08.014 · 2.73 Impact Factor
Article: Evidences of the Recombinant Origin of a Bat SARS-like Coronavirus and its Implications on the Direct Ancestor of SARS Coronavirus
Article: Screening of differentially expressed transcripts in infectious bursal disease virus-induced apoptotic chicken embryonic fibroblasts by using cDNA microarrays.[Show abstract] [Hide abstract]
ABSTRACT: Infectious bursal disease virus (IBDV) induces apoptosis and immunosuppression. To understand the molecular mechanisms involved in the pathogenesis of infectious bursal disease (IBD) and the host-directed antiviral responses, cDNA microarrays were used to identify the differentially expressed transcripts in IBDV-infected chicken embryonic fibroblasts. The results suggest a general suppression of surface receptors, including CD40 ligand and SEMA4D. These are related to T- and B-cell activation and differentiation, which may contribute to the immunosuppression of IBD. In addition, activation of genes involved in Toll-like receptor- and interferon (IFN)-mediated antiviral responses was detected. In particular, upregulation of Toll-like receptor 3, a double-stranded (ds) RNA receptor, and MX1, an IFN-inducible antiviral GTPase, may represent the possible host-directed defence responses against the virus and its dsRNA genome. Interestingly, several lines of evidence suggest the modulation of G protein-coupled receptors and receptor tyrosine kinase signalling pathways, especially the possible transactivation of epidermal growth factor receptor by lysophosphatidic acid. Alteration of these may contribute to the previously reported activation of mitogen-activated protein kinases upon IBDV infection, resulting in macrophage activation and inflammatory responses. Additionally, numerous target genes and inducers of nuclear factor kappa B (NF-kappaB) were upregulated profoundly, implying that IBDV may modulate host-cell survival and apoptosis to support its replication and facilitate viral spread through NF-kappaB activation. In summary, this investigation of host-gene expression unravelled the candidate physiological pathways involved in host-virus interaction on a molecular level, providing a foundation for researchers to design experiments based on testable hypotheses targeting individual genes.Journal of General Virology 07/2007; 88(Pt 6):1785-96. DOI:10.1099/vir.0.82619-0 · 3.53 Impact Factor
Article: Demonstration of receptor binding properties of VP2 of very virulent strain infectious bursal disease virus on Vero cells[Show abstract] [Hide abstract]
ABSTRACT: Tissue culture adaptation of infectious bursal disease virus (IBDV) results in alternation of three residues on its major capsid protein VP2 and these residues may engage in receptor binding. Although the key of successful infection of tissue culture adapted IBDV in tissue cultures was defined as the virus entering steps, mechanism of the adaptation is poorly understood. In this study, recombinant VP2s of an attenuated strain (D78) and a very virulent strain (HK46) of IBDV tagged with rabbit immunoglobulin G heavy chain were expressed in mammalian cells, generating RAVP2 and RVVP2, respectively, in high purity. Using flow cytometry, both RAVP2 and RVVP2 were demonstrated to bind with Vero cells while these bindings were blocked by D78 viral particles, implying both very virulent IBDVs (vvIBDVs) and attenuated IBDVs bind to Vero cells through the same receptor(s). Since vvIBDVs cannot be propagated directly in tissue cultures, the specific binding between RVVP2 and Vero cells suggests the barrier for tissue culture adaptation may be beyond the virus attachment process.Virus Research 02/2007; 123(1):50-6. DOI:10.1016/j.virusres.2006.08.001 · 2.83 Impact Factor
Article: Naturally occurring anti-Escherichia coli protein antibodies in the sera of healthy humans cause analytical interference in a recombinant nucleocapsid protein-based enzyme-linked immunosorbent assay for serodiagnosis of severe acute respiratory syndrome.[Show abstract] [Hide abstract]
ABSTRACT: We reported the analytical interference of anti-Escherichia coli protein (EP) antibodies in human sera and residual EP in a recombinant nucleocapsid protein-based enzyme-linked immunosorbent assay as a possible source of false positives in severe acute respiratory syndrome serodiagnosis. The rate of false positives was significantly reduced by adding mouse anti-EP antiserum in the blocking step.Clinical and Vaccine Immunology 02/2007; 14(1):99-101. DOI:10.1128/CVI.00136-06 · 2.37 Impact Factor
Article: Quantitative comparison of the efficiency of antibodies against S1 and S2 subunit of SARS coronavirus spike protein in virus neutralization and blocking of receptor binding: implications for the functional roles of S2 subunit.[Show abstract] [Hide abstract]
ABSTRACT: Neutralizing effects of antibodies targeting the C-terminal stalk (S2) subunit of the spike protein of severe acute respiratory syndrome coronavirus have previously been reported, although its mechanism remained elusive. In this study, high titered mouse antisera against the N-terminal globular (S1) and S2 subunits of the S protein were generated and total immunoglobulin G (IgG) was purified from these antisera. The efficiency of these purified IgGs in virus neutralization and blocking of receptor binding were compared quantitatively using virus neutralization assay and a previously developed cell-based receptor binding assay, respectively. We demonstrated that anti-S1 IgG neutralizes the virus and binds to the membrane associated S protein more efficiently than anti-S2 IgG does. Moreover, both anti-S1 and anti-S2 IgGs were able to abolish the binding between S protein and its cellular receptor(s), although anti-S1 IgG showed a significantly higher blocking efficiency. The unexpected blocking ability of anti-S2 IgG towards the receptor binding implied a possible role of the S2 subunit in virus docking process and argues against the current hypothesis of viral entry. On the other hand, the functional roles of the previously reported neutralizing epitopes within S2 subunit were investigated using an antigen specific antibody depletion assay. Depletion of antibodies against these regions significantly diminished, though not completely abolished, the neutralizing effects of anti-S2 IgG. It suggests the absence of a major neutralizing domain on S2 protein. The possible ways of anti-S2 IgGs to abolish the receptor binding and the factors restricting anti-S2 IgGs to neutralize the virus are discussed.FEBS Letters 11/2006; 580(24):5612-20. DOI:10.1016/j.febslet.2006.08.085 · 3.34 Impact Factor
Article: Phylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment B.[Show abstract] [Hide abstract]
ABSTRACT: Infectious bursal disease virus (IBDV) is a birnavirus causing immunosuppressive disease in chickens. Emergence of the very virulent form of IBDV (vvIBDV) in the late 1980s dramatically changed the epidemiology of the disease. In this study, we investigated the phylogenetic origins of its genome segments and estimated the time of emergence of their most recent common ancestors. Moreover, with recently developed coalescence techniques, we reconstructed the past population dynamics of vvIBDV and timed the onset of its expansion to the late 1980s. Our analysis suggests that genome segment A of vvIBDV emerged at least 20 years before its expansion, which argues against the hypothesis that mutation of genome segment A is the major contributing factor in the emergence and expansion of vvIBDV. Alternatively, the phylogeny of genome segment B suggests a possible reassortment event estimated to have taken place around the mid-1980s, which seems to coincide with its expansion within approximately 5 years. We therefore hypothesize that the reassortment of genome segment B initiated vvIBDV expansion in the late 1980s, possibly by enhancing the virulence of the virus synergistically with its existing genome segment A. This report reveals the possible mechanisms leading to the emergence and expansion of vvIBDV, which would certainly provide insights into the scope of surveillance and prevention efforts regarding the disease.Journal of Virology 10/2006; 80(17):8503-9. DOI:10.1128/JVI.00585-06 · 4.65 Impact Factor
Article: Adenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells[Show abstract] [Hide abstract]
ABSTRACT: The pro-apoptotic properties of severe acute respiratory syndrome coronavirus (SARS-CoV) structural proteins were studied in vitro. By monitoring apoptosis indicators including chromatin condensation, cellular DNA fragmentation and cell membrane asymmetry, we demonstrated that the adenovirus-mediated over-expression of SARS-CoV spike (S) protein and its C-terminal domain (S2) induce apoptosis in Vero E6 cells in a time- and dosage-dependent manner, whereas the expression of its N-terminal domain (S1) and other structural proteins, including envelope (E), membrane (M) and nucleocapsid (N) protein do not. These findings suggest a possible role of S and S2 protein in SARS-CoV induced apoptosis and the molecular pathogenesis of SARS.FEBS Letters 01/2006; 579(30):6699-704. DOI:10.1016/j.febslet.2005.10.065 · 3.34 Impact Factor
Article: Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray.[Show abstract] [Hide abstract]
ABSTRACT: Proteins and peptide bound polysaccharides (PSP) extracted from Basidiomycetous fungi are widely used in cancer immunotherapy and recently demonstrated to induce apoptosis in cancer cells in vitro. In order to provide the molecular pharmacological mechanisms of PSP on human cancer cells, we investigated the gene expression profiles of PSP-treated apoptotic human promyelotic leukemic HL-60 cells using ResGen 40k IMAGE printed cDNA microarray. In total 378 and 111 transcripts were identified as differentially expressed in the apoptotic cells by at least a factor of 2 or 3, respectively. Our data show that PSP-induced apoptosis in HL-60 cells might be mediated by up-regulation of early transcription factors such as AP-1, EGR1, IER2 and IER5, and down-regulation of NF-kappaB transcription pathways. Other gene expression changes, including the increase of several apoptotic or anti-proliferation genes, such as GADD45A/B and TUSC2, and the decrease of a batch of phosphatase and kinase genes, may also provide further evidences in supporting the process of PSP induced apoptosis in cancer cells. Some of the well-characterized carcinogenesis-related gene transcripts such as SAT, DCT, Melan-A, uPA and cyclin E1 were also alternated by PSP in the HL-60 cells. These transcripts can be employed as markers for quality control of PSP products on functional levels. The present study provides new insight into the molecular mechanisms involved in PSP-induced apoptosis in leukemic HL-60 cells analyzed by cDNA microarray.International Journal of Oncology 09/2005; 27(2):513-23. DOI:10.3892/ijo.27.2.513 · 2.77 Impact Factor
Article: Reverse transcriptase PCR diagnostic assay for the coronavirus associated with severe acute respiratory syndrome.[Show abstract] [Hide abstract]
ABSTRACT: Recent outbreaks of severe acute respiratory syndrome (SARS) have spurred intense research efforts around the world to deal with the serious threat to health posed by this novel coronavirus. A rapid, reliable diagnostic assay is needed for monitoring the spread of the disease. Here we report a method for eliminating false-negative results and increasing test sensitivity, based on the hypothesis that the message encoded by the nucleocapsid (N) gene is the most abundant during viral infection. Nasopharyngeal aspirates and stool samples were obtained from suspected SARS patients with major clinical symptoms and a significant history of close contact with infected patients. Total RNAs were extracted in a 96-well format, together with pig kidney epithelial (PK-15) cells as an internal control for extraction efficiency. PCR inhibitors were removed by ethanol precipitation, and a PCR for the pig beta-actin gene was used as a positive control for all clinical samples. Samples were analyzed by a reverse transcriptase PCR assay. Northern blot analysis was performed to demonstrate differences in subgenomic transcripts of the virus, and a real-time quantitative PCR was employed to compare the sensitivities of two loci (1b and N). The detection rate of the assay reached 44.4% on day 9 after the onset of the disease. The diagnostic PCR amplifying the N gene gave an average of a 26.0% (6.3 to 60.0%) stronger intensity signal than that for the 1b gene. In conclusion, the nucleocapsid gene represents an additional sensitive molecular marker for the diagnosis of the SARS coronavirus and can be further adapted for use in a high-throughput platform assay.Journal of Clinical Microbiology 06/2004; 42(5):1994-9. DOI:10.1128/JCM.42.5.1994-1999.2004 · 4.23 Impact Factor
Top Journals
The University of Hong Kong
Hong Kong, Hong Kong
- School of Biological Sciences
Wuhan Institute Of VirologyWu-han-shih, Hubei, China
University of Auckland
Auckland, Auckland, New Zealand
- Department of Computer Science


text:
The "Reasons My Kid Is Crying" Book Is Freaking Hilarious
"I wouldn't let him play with the dead squirrel he found in the yard."
Last year Greg Pembroke started a Tumblr to post photos of his kids melting down along with the ridiculous reasons they were crying.
Greg, with his wife, Charity, and sons, William, 3, and Charlie, 22 months.
The Tumblr went viral, and Greg soon began receiving submissions from parents all around the world, the best of which have been compiled into a new book, Reasons My Kid Is Crying.
The caption that goes with this photo is "We gave him delicious pudding."


text:
Birding Festival
Festival Field Trips
Sax-Zim Bog Shirts
Festival FAQ
About Sax-Zim
Maps of the Bog
Gallery Form
Sax-Zim Stories
Stories Form
Sax Zim Guides
Bird list
Friends of the Sax Zim Bog
Top Birding Tours
These maps shows birders the best places to visit to see certain Sax-Zim Bog bird specialties. The blue circles on the Sax-Zim map show where the residential winter bird feeding stations are located at. The Morse's feeders are located on the Blue Spruce Rd a mile north of CR 133. The Abramson's feeders are located 1/4 mile north of CR 133 on the Little White Face Road. The Mueller's feeders are located on CR 201 & the Dart Rd. After you cross over the Dart Rd. the first house on your right is the Mueller's residence. The green circles on the Sax-Zim map show where the Admiral Rd feeders and Arkola Rd feeders are located. These feeders have been regular feeding stations for the last 3-4 years but it all depends on volunteers who erect feeders at these locations and keep them filled with feed.
Meadowlands Community Center
Map to Meadowlands, MN
Sharp Tailed Grouse Area Map
Sax-Zim Bog Map
Admiral Road Feeders Map
Meadowlands Feeders Map
Kelsey Feeders Map
We look forward to seeing you at the 2015 Sax-Zim Bog Winter Bird Festival!
Follow Us!
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text:
@taichokage: what the thread ? yeah it's entertainment alright
@akronawol17 said:
Lol, goku split a mountain in ssj 1 and superman has sneezed planets to pieces. Don't even get me started on the others. Hell, kid goku lifted a car in the first chapter of DB.
Superman sneezed? Dude, the T-800 could destroy a goddamn solar system with a fake cough for fuck sakes..=/ Yet the shit Supermans done such as sneezing solar systems apart is that impressive? The T-800 swallowed a Solar system before and can lift up to 999,billion,nine hundred, seventy eight centillion of what the planet Jupiter is.
The T-800 would pick up a semi truck and throw it at Superman, Hulk, Thor, Odin, Galactus and Goku and they're dead. they never got hit and run over by a truck like the T-800 did to prove they can withstand such damage...... shhhhhhhhhhhhh your face...........
TERMINATOR Destroys.


text:
Book your room at Guesthouse Vineyard Inn Mcminnville
Single Room, 1 Queen BedMax Occupancy: 2 guests (up to 1 child)
Single Room, 1 Queen Bed with SofabedMax Occupancy: 3 guests (up to 2 children, 1 infant)
Standard Room, 1 King BedMax Occupancy: 2 guests (up to 1 child, 1 infant)
Standard Room, 2 Queen BedsMax Occupancy: 4 guests (up to 3 children, 2 infants)
McMinnville hotel with an indoor pool
Situated near the airport, in McMinnville, this hotel is close to Eyrie Vineyards. Area attractions also include Evergreen Aviation and Space Museum.
Hotel Features
At Guesthouse Vineyard Inn Mcminnville, recreational amenities include an indoor pool and a spa tub. The hotel also features laundry facilities and RV/bus/truck parking.
Room Amenities
Televisions come with satellite channels. Guestrooms also feature complimentary wireless Internet access, refrigerators, and microwaves.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
In addition to an indoor pool, Guesthouse Vineyard Inn Mcminnville provides a spa tub and a fitness center. A complimentary breakfast is offered each morning. This McMinnville hotel also offers tour/ticket assistance, laundry facilities, and RV/bus/truck parking.
Guesthouse Vineyard Inn Mcminnville is a smoke-free property.
- Total number of rooms - 65
- Free breakfast
- Fitness facilities
- Tours/ticket assistance
- Laundry facilities
- RV, bus, truck parking
- Smoke-free property
- Spa tub
- Indoor pool
Available in all rooms: Free WiFi
RV, bus, truck parking
Room Amenities
- Coffee/tea maker
- Free newspaper
- Free local calls
- Free long-distance calls
- Refrigerator
- Microwave
- Hair dryer
- Iron/ironing board
- Television
- Desk
- Satellite TV service
- Free WiFi
Where to Eat
Guests are offered a complimentary continental breakfast each morning.
Nearby Things to Do
An indoor pool and a spa tub are on site. Other recreational amenities include a fitness center.
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- In-room accessibility
Hotel Policies
Check-in time starts at 3 PM
Check-out time is noon
Payment types
Pets allowed, Only dogs are allowed
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Pet fee: USD 10 per pet, per night


text:
Nicole Anderson and Justin Gunderson announce their engagement.
Parents of the couple are Paul and Julie Anderson; and Gary and Barbara Gunderson.
Nicole graduated from Crosby-Ironton High School and UMD-Duluth. She is employed at Baxter Elementary, in the Brainerd area.
Justin graduated from Detroit Lakes Senior High and UMD-Duluth. He is employed by RMB Lab in Detroit Lakes.
A Jan. 2, wedding is planned at St. Joseph Catholic Church in Crosby Ironton.
Are you a newspaper subscriber but you don't have a Digital Access account yet? https://secure.forumcomm.com/?publisher_ID=40&event=subscriber/lookup.
You will need your subscription account number and phone number. Not sure if you have an account? Email us at email@example.com and we can help you.


text:
Auto Repair, Knoxville, TN
Rice Automotive
8330 Kingston Pike, Knoxville, TN 37919
McCown, Jeff K
1609 Lovell Rd, Knoxville, TN 37932
Lee's Specialtee LLC
322 Tillery Rd, Knoxville, TN 37912
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- Drive a little smarter.®Visit our website for available auto services and online coupons!
- 8858 Kingston Pike, Knoxville, TN 37923
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Safelite AutoGlass - Knoxville
11235 Threadstone Ln, Knoxville, TN 37932
Save Time, Schedule Online Now
Hunter Oil Company, INC.
320 Leeper Pkwy, Lenoir City, TN 37772
Hunter Oil Company, Inc. has been offering a comprehensive line of Automotive, Industrial, and Commercial Lubricants for over 50 years.
Firestone Complete Auto Care
5601 Kingston Pike, Knoxville, TN 37919
Keep Your Car Running Newer, Longer. Schedule An Appointment Today.
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"Mike Mize at Mize Autos has to be the best mechanic in town. I have had the opportunity of ...">
All PRO Services
5610 Middlebrook Pike, Knoxville, TN 37921
1.7 Miles
"I am a single mother of four that have been going to All Pro for 15 years that have taken go...">
Black Oak Automotive
6109 Tazewell Pike, Knoxville, TN 37918
10.9 Miles
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2538 E Broadway Ave, Maryville, TN 37804
12.2 Miles
"recently i got a window tint done on my infinity. the young lady did a very nice job and i h...">
J & H Automotive
332 Boyds Creek Highway, Seymour, TN 37865
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"I go here all the time and i send any and everyone i know, Jeff is very fair on the prices a...">
Advanced Transmissions
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"advanced transmission in Clinton TN on Clinch Ave is not a trust worthy repair shop. I am no...">
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2707 Old Callahan Dr, Knoxville, TN 37912
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East Knoxville Truck Repair
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"incompetent and untruthful. Had no problems fixed, caused more and emptied my bank account.">
Brothers Body Shop
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13.9 Miles
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Atomic Car Audio And Access
214 Brisbane Rd Ste 2, Oak Ridge, TN 37830
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Rivers Total Car Care
110 Oak Ridge Tpke, Oak Ridge, TN 37830
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"customers beware. This place originally was a good place to take your car. But recently I ha...">
Flite Tire & Auto Repair Center
5707 Clinton Highway, Knoxville, TN 37912
3.0 Miles


text:
Displaying gems 3331 - 3360 of 4466 in total
grape-gen 0.0.6
Grape-powered rack application generator with batteries included
1,466 Downloads
grape-hal 0.0.1
Provides the HAL response for Grape API application
611 Downloads
grape_hal_integration 0.1.0
Automatically generates links between endpoints, help with referencing to endpoint, end...
540 Downloads
grape_has_scope 0.2.0
has_scope implementation to use with Grape API
1,457 Downloads
grape-jbuilder 0.2.0
Use Jbuilder in Grape
14,099 Downloads
grape-juice 0.0.2
Rspec matchers for grape-entity
275 Downloads
grape-kaminari 0.1.7
kaminari paginator integration for grape API framework
23,644 Downloads
grape-librato 1.1.0
librato metrics for grape
10,485 Downloads
grape-markdown 0.0.6
Auto generates Markdown from the docuementation that is created by your Grape API
3,310 Downloads
grape-msgpack 0.1.2
msgpack formatter for grape
10,006 Downloads
grape-oink 0.0.1
A middleware for Grape to allow working with Oink.
176 Downloads
grape-pagination 0.1.0
Pagination helpers for Grape
4,453 Downloads
grape-papertrail 0.1.1
Papertrail support for Grape APIs
1,625 Downloads
grape_press 0.0.1
Generator for Grape API projects.
365 Downloads
grape-rabl 0.3.1
Use rabl in grape
61,343 Downloads
grape-rails-cache 0.1.2
HTTP and server side cache integration for Grape and Rails
9,676 Downloads
grape-rails-routes 1.0
After you mount Grape API routes into Rails, Grape API routes would normally not be pri...
1,486 Downloads
grape-raketasks 0.0.3
Provides rake tasks to ease the development and debugging of Grape APIs.
2,143 Downloads
grape-reload 0.1.0
Grape autoreload gem
1,290 Downloads
grape-resource-definition 0.1.1
Grape Resource Definition, separating API design from implementation
1,491 Downloads
grape-resources 0.0.2
Grape resources provides the initial scaffolding for a model in a Grape api object, thi...
472 Downloads
grape-roar 0.3.0
Use Roar with Grape
3,257 Downloads
grape_session 0.0.3
Adds Rails like session support to grape api
1,178 Downloads
grape-shaman_cache 0.3.0
HTTP and server side cache integration for Grape and Rack applications
1,570 Downloads
grape_sinatra_helpers 0.0.2
Small subset of Sinatra helper methods ported to Grape
2,511 Downloads
grape-slate 0.0.6
Auto generates a Slate (https://github.com/tripit/slate) document from the docuementati...
2,855 Downloads
grape-swagger 0.10.1
A simple way to add auto generated documentation to your Grape API that can be displaye...
191,662 Downloads
grape-swagger-rails 0.1.0
Swagger UI as Rails Engine for grape-swagger gem
26,010 Downloads
grape-swagger-ui 0.0.9
swagger ui js integration for grape and grape-swagger
16,860 Downloads
grape-throttle 0.0.0
A middleware for Grape to add endpoint-specific throttling.
298 Downloads


text:
Warhol's 'geniuses' on view at Jewish Museum Milwaukee
When it was first unveiled in 1980, Andy Warhol's series of images of famous Jews, called "Ten Portraits of Jews in the Twentieth Century," was greeted with some of the most shrill criticism Warhol ever got. »Read Full Article(1)
Lady Antebellum connects with fans, not feelings, at State Fair
Lady Antebellum is probably the biggest country-pop group of the last decade, primarily because it has a knack for locating the universal. Or for dressing up the lowest common denominator to look, feel and sound like the universal.
The distinction didn't make a difference to the packed crowd attending the group's show at the Wisconsin State Fair Main Stage Saturday night. »Read Full Article(14)
Festivals and free concerts this week in the Milwaukee area
Wisconsin State Fair: 8 a.m.-10 p.m. Aug. 10, State Fair Park, 640 S. 84th St., West Allis, (800) 884-3247 or www.wistatefair.com »Read Full Article


text:
Steven Tyler
Aerosmith and Cheap Trick Rock Classics, Deep Cuts In New Jersey
Last night, two of America's greatest and most enduring rock bands held court at New Jersey's Izod Center. Aerosmith and Cheap Trick, both decades into their career, unleashed some of the greatest rock songs from the '70s through the modern era. Both bands played their biggest hits, but eschewed some obvious songs to dig deeper into their considerable catalogs.
'Idol' Shake Up: Who Will Take Over For J.Lo and Steven Tyler?
With both Jennifer Lopez and Steven Tyler saying goodbye to American Idol last week, we're rounding up the rumored candidates who are competing to fill their shoes.
JACK's Inside Track: Steven Tyler
Randy Jackson is officially the guy at the party who won't leave. Yo Dawg, we're outta Cheetos! Go home!
Steven Tyler To "Let Go Of My Mistress 'American Idol' Before She Boils My Rabbit"
Fox has just confirmed that Steven Tyler is leaving American Idol. The Aerosmith singer said in a press statement that "After some long…hard…thoughts…I've decided it's time for me to let go of my mistress American Idol before she boils my rabbit.
Aerosmith Reschedules Concert, Steven Tyler On Vocal Rest
Just five shows into Aerosmith's Global Warming tour, the Boston-bred rockers must reschedule a tour stop.
JACK's Inside Track: Aerosmith
What'd you think of JACK FM's Dad Looks Like a Lady Father's Day Frenzy? I bet some 'Smith fans went home and planted the seed to become a father after that show. The POWER of […]
From "Sgt. Pepper's" to "Be Cool": Steven Tyler's Film Roles Through The Years
Steven Tyler has one of rock's most recognizable voices – a raspy delivery that will soon voice an animated character in Epic, a 3D animated feature from the filmmakers behind Ice Age and Rio. The […]
Steven Tyler Backstage At "Idol": "Let's Just Say We Got Aerosmith Back"
Amid the craziness of the season finale of American Idol, Steven Tyler took some time at a backstage press event to speak about Aerosmith and the status of their upcoming new album and tour.
JACK's Inside Track: Aerosmith Idol
Wonder why Joe Perry changed his mind about playin' American Idol after he swore it off for years? Oh, I know–the ability to reach millions of potential Aerosmith record-buyin' couch potatoes!
Aerosmith Set To Perform On American Idol Season Finale
Aerosmith will perform on the American Idol season finale on May 23rd. The rockers will take advantage of the fact that their singer is a judge on the popular reality program to create hype for […]


text:
i need to know what to do in order to make the control for the mirrors to work.
Lexus Q&AAsk Your Question
All 1999 Lexus RX300 questions
control for mirror
How reliable with over 125,000 miles
I have owned since 25,000 miles. has 125,000 miles. Fully maintained. Just put new brakes on. ...
Ignition coils
how much does it cost to replace the ignition coils in the RX300
how to replace thermostate
car overheating and then suddenly cools, sounds verymuch like a bad thermostste
check engine light
I noticed my check engine light come on, and i also get a knocking sound when i try to accelerate...
check engine light and trac control OFF and then it runs real rough
This has occured many times in the last few weeks, i have been told that it is some type of contr...
No Tail lights- searching for tail light relay
Where is the tail light relay located? Could this be my problem?
estimated cost of repair.
What would it cost to replace a locked up transfer case, which jamed up and cracked spline in tra...
This question has recently been posted - here's more detail about the problem. Vibration feel...
Just had my transmission replaced. Afterward, there is a vibration sound. Put in a drive line a...
Selecting durable starter
Is there a difference in reliability between a OEM and an after-market starter? Also, prices var...
How do I tighten mounting plate to front driver's side strut assembly?
I have a rattle coming from front-driver's side whenever i hit a bump or make a turn. I beli...
front brakes has "pulsating" feel whenever I brake. Is it due to warp rotors?
My front brakes has "pulsating" feel when I brake. One mechanic says rotor requires mac...
What's creating rattle sound from front drivers side whenever I go over bumps?
I had ALL my struts replaced about a year ago. In addition, I had a rear mounting plate (part of...
Car will not start after turning the ignition. Is the starter the culprit?
My car will not start after turning the ignition key. I hear a "clickin" sound. Howeve...
This week's top 10
|1 stevieray1
|6 ziptie12
|2 pushrod
|7 Hal...
|3 globalhelper
|8 RCMotors
|4 CharlesAutomotive
|9 kaelinsanity
|5 csubak30
|10 wrayauto


text:
Best Of The Joy Of Painting
LONELY RETREATSeries Website »
Episode Guide »
Beautiful blue effects on canvas highlight the drama and beauty of a snow-bound cabin at sunset.
Holly is on a mission to get to know more Vermonters, what inspires them, what makes them tick, and to learn how Vermont PBS can better serve. Watch the video...
Did you miss Brothers of the Gut? You can still order the DVD. Check out the documentary page for more info!
Original series, specials, documentaries and web shows produced by Vermont PBS
A second HD broadcast service offering alternative programming and more content from local and regional producers.


text:
Photos: Noise Pop 2011
By Pitchfork on February 28, 2011 at 11:45 a.m. EST
Photos by Misha Vladimirskiy; Above: Best Coast
San Francisco's Noise Pop festival went down this past week, featuring Best Coast, Wavves, No Age, Yo La Tengo, Dan Deacon, Ted Leo, the Concretes, and many more. Photos by Misha Vladimirskiy.
Check out a selection of photos after the jump, then head over to our Facebook page for even more photos.
New Wavves: "Horse Shoes"
By Ryan Dombal on February 21, 2011 at 11:20 a.m. EST
Photo by Lauren Dukoff
Wavves' Nathan Williams just posted this new song on his blog. It's a bit more on the garage side of the garage-punk divide and ends with a manic slash of sped-up guitars and drums. Williams and drummer Zach Hill performed the track in an earlier form on a Daytrotter session in 2009, but the track has been reworked. Check it out.
New Wavves: "TV Luv Song"
By Tom Breihan on February 16, 2011 at 6:30 p.m. EST
"TV Luv Song" is a jittery new pop-punk track from Wavves about wasting all your time watching television and feeling just fine about it. According to Spin, the song is "the first in an upcoming batch of music [Wavves frontman Nathan] Williams will be releasing on his own," and it could end up on a 7" single. According to Wavves' Twitter, the image above is the single art, and it comes from artist Robert Wolfe. Head over to Spin to stream the track (their download isn't working).
Watch: Wavves Play New Song Live
By Ryan Dombal on February 14, 2011 at 1:35 p.m. EST
Photo by Kathryn Yu
Here's a high-quality live video of a new song called "Bug" by Wavves, via Prefix. The song is about some douchebag and the video was recently recorded at Athens, Georgia's 40 Watt Club by RadioVA. Watch below:
Echo Chamber: Wavves on Drug Paraphernalia
By Larry Fitzmaurice on February 10, 2011 at 3:10 p.m. EST
Photo by Will Dietz
"No bongs or pipes though. That's how they threw [Tommy] Chong in jail, I'm not going to fuck with that; the rolling papers and grinders are enough for now."
-- Wavves' Nathan Williams, discussing the limits to his drug paraphernalia-hawking exploits (which, yes, now include Wavves-branded rolling papers). He also mentions the possibility of a Wavves-branded strain of weed; good to know he's got his priorities straight. (via Spinner)
Best Coast Plays "Letterman", Meets Justin Bieber
By Tom Breihan on February 1, 2011 at 11:00 a.m. EST
Last night, SoCal fuzz-poppers Best Coast performed on the "Late Show With David Letterman", which gave leader Bethany Cosentino the opportunity to pose for a photo with fellow "Letterman" guest Justin Bieber (that's not a Photoshop up there) and the rest of the world the opportunity to hear Letterman say "Snacks the cat." Cosentino really gives her voice a workout during this rendition of "Each and Every Day", which you can watch below, via Consequence of Sound.
Also last night, Best Coast played a co-headlining show with Wavves at Washington, D.C.'s 9:30 Club. NPR Music hosted live webcasts of the sets from both bands. And right now, you can stream both sets in full on the NPR website.
Echo Chamber: Best Coast's Bethany Cosentino on the Time She Dumped Wavves' Nathan Williams
By Larry Fitzmaurice on January 24, 2011 at 11:40 a.m. EST
"I dumped him. I was mean to him, apparently: I called him an idiot because he was dancing on the table in a bar. If I was smarter then, I would've stuck a dollar bill in his underwear."
-- Best Coast's Bethany Cosentino on lessons learned from love (almost) lost when she dumped Wavves' Nathan Williams when they were 17. Spoiler alert: they got back together. (via the Los Angeles Times)
Listen: Wavves: "Mutant"
By Larry Fitzmaurice on January 17, 2011 at 11:40 a.m. EST
Photo by Will Deitz
Hot on the heels of his psych'd-out new song "Stained Glass (Won't You Let Me Into Yr Heart)", from his Summer Is Forever EP split with Best Coast, Wavves main bro Nathan Williams took to his blog over the weekend to give away another jam, "Mutant", which you can check out above.
Best Coast's Cat Snacks + LOLcats = Win
By Larry Fitzmaurice on January 14, 2011 at 2:05 p.m. EST
If anything, it's a surprise this didn't happen sooner. The funny-kitty-photo-with-caption-meme blog I Can Has Cheezburger has teamed up with Best Coast and her ubiquitous cat Snacks for a photo caption contest. I'd make a joke about that Best Coast lyric about wishing her cat could talk, but alas, I Can Has Cheezburger beat me to it already.
New Wavves: "Stained Glass"
By Larry Fitzmaurice on January 10, 2011 at 2:35 p.m. EST
Front page photo by Will Dietz
Hey, remember that split single between Wavves and Best Coast to commemorate their forthcoming tour that we told you about last week? Well, apparently the thing hits iTunes tomorrow, and Bananas Music Club has a stream of Wavves' contribution to the single, "Stained Glass (Won't You Let Me Into Yr Heart)".
Click here to check out the track, a zany psych-pop song that wouldn't have been out of place on the last MGMT record.
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Kanye West Releases Nudity-Filled Season Zine
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Coachella 2015 Lineup Announced
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Kendrick Lamar's To Pimp a Butterfly is Out Now
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Kendrick Lamar Announces Album Release Date
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Gorillaz Creator Jamie Hewlett Confirms Group's Return on Instagram
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Using the import vector feature from NewBlue Titler Pro 3, you can create dynamic results with vector files using unique built-in animations. Here's how.
Using the Halovision Plus plugin from NewBlue Transitions 3 Ultimate, you can recreate the look of bokeh lighting with a halo of light around your subject. Here's how.
Using the ColorFast plugin from NewBlue Filters 3 Ultimate, you can quickly add vibrance and beauty to an otherwise dull scene.
Using the Skin Touch Up plugin from NewBlue Essentials 3 Ultimate, you can soften wrinkles and remove blemishes without retouching the entire image. Here's how.
Using the Viewfinder plugin from NewBlue Elements 3 Ultimate, you can create that classic home movie look in seconds. Here's how.


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Comfort Suites
310B Greenbriar Dr.
Normal, IL 61761
Phone: (309) 452-8588
Fax: (309) 452-8588
Beauty & Spas
»The Fitness Center
Fitness center is your solution to beat the flab. They have a lot of schemes to suit all needs. Programs for individuals, groups, seniors and also to de-stress those in the corporate world. Also, there are special discounts for students and corporate employees. Other facilities include free supervised playroom with infant care, luxury locker rooms and lobby, court sports, massage therapy and the icing on the cake free Wi-Fi all day long. The trainers are certified and give individual personal attention to ensure your success. Kudos to Fitness Center.


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Sewing for Beginners
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Cheap and Handy Pin Cushion
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A flat, rectangular bar of soap works well as a pin cushion. The soap will help your pins and needles to slide through fabric more easily.
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A bar of IVORY soap is best for this use. Its soft and the pins slide in easily. Most bar soaps are hard milled and will crack.
Jun 26, 2010
i am going to try this it sund fesable
Helen P
May 16, 2010
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New Balance M1500 – White – Orange – Green by Patrick Johnson 0 Comments
no thanks..
December 3, 2013 BY Brendan Dunne / 1
It turns out there is yet another New Balance collaboration on the way-this one set to release just a week after Ronnie Fieg hit us with a double dosage. We're speaking of the Saint Alfred x New Balance 1500, a sneaker that's just now been revealed. As you can see it's a tonal red affair that gets finished off with a gum sole on bottom. The suede selected appears particularly nappy, which should have quite a few excited given the synthetic suede that we're so used to seeing on today's footwear releases. Continue reading to get some additional angles and watch for them to drop at Saint Alfred this Saturday, December 7th.
Saint Alfred x New Balance 1500
Release Date: 12/07/13
Source: saintalfred
Filed under: Collaboration New Balance Upcoming Sneakers
New Balance M1500 – White – Orange – Green by Patrick Johnson 0 Comments
New Balance 1500 "Made In UK" – Navy Leather by Zack Schlemmer 0 Comments


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2013's 7 Best Brand Stories
Read More About
My year-end top brand stories recap was well received last year, and I decided to do it again. I'll break from my usual Q&A format to recap this year's most important brand developments in fast food.
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My year-end top brand stories recap was well received last year, and I decided to do it again. I'll break from my usual Q&A format to recap this year's most important brand developments in fast food.
A handful of quick-service brands released games for mobile platforms in 2013, and the apps proved to be more than just for fun. In fact, some brands are reporting increased sales and customer loyalty by integrating games within their apps.
Among the restaurant companies that found success this year with app games were Blimpie, McDonald's, and Chipotle.
Despite a year filled with turmoil in Washington, the limited-service restaurant industry showed moderate growth and promise in 2013, thanks in part to creative new ideas and products, plus another good gain from fast-casual units.
With issues such as sequestration, a payroll tax increase, the government shutdown, and the Affordable Care Act hanging over the industry, it's perhaps not surprising that gains have only been nominal, despite employment increases and an improving economy.
Beef, pork, poultry, and seafood may be the staples of the limited-service restaurant industry, but non-meat items aren't taking a back seat on the menu these days. Although vegetarians make up a small percentage of the American dining population, an increasing number of consumers are deciding to eat less meat.
"Ten years ago, it might have seemed like a fad, with just a small population, but it's been constantly increasing," says Jesse Gideon, corporate chef and chief operating officer for Fresh To Order, a 10-unit fast-casual chain based in Atlanta.
Ordering a beer with your burger or a margarita with the taco special at your favorite fast-casual restaurant used to be a rarity, but more concepts are now offering alcoholic selections, from beer to signature cocktails. With the increased awareness and education of adult beverage culture in our society, consumers are expecting, even demanding, a better selection of adult refreshments with their meals, causing more fast-casual concepts to take a look at alcoholic beverage programming.
Last year, activists in California collected 1 million signatures to put the California Right to Know Genetically Engineered Food Act on the November 2012 ballot. Named Proposition 37, the measure sought to make California the nation's first state to require the labeling of foods that included genetically modified organisms (GMO).
Consumers are bombarded with advertisements every day, from commercials during their favorite TV shows to sponsored Facebook ads on their newsfeed.
Rather than getting lost in the shuffle, limited-service brands are looking to a new approach to marketing to increase their brand awareness and build trust with consumers: content marketing.
Content marketing goes beyond the traditional promotions, menu development shout-outs, and marketing campaigns and provides a brand's customers with content and information that they actually need and want.
Chipotle Mexican Grill announced the return of its long-standing tradition and popular Halloween fundraiser known as Boorito. This Halloween, Chipotle will treat customers dressed in costume to a burrito, bowl, salad, or order of tacos for only $3 from 4 p.m. to closing. Proceeds from the fundraiser of up to $1 million will benefit the Chipotle Cultivate Foundation.
Sustainable practices are all the rage across the restaurant industry these days.
The expansive show floors at the National Restaurant Association's annual trade show in May confirmed that the momentum behind these initiatives isn't waning. From tableware and takeout containers to faucets, lighting, and cleaning products, green was the word. That also extends to the proteins most quick-service and fast-casual restaurants use as their menuboard centerpieces.
Chipotle Mexican Grill launched "The Scarecrow," an arcade-style adventure game for iPhone, iPad, and iPod touch, along with a companion animated short film of the same name.
Both the game and the film depict a scarecrow's journey to bring wholesome food back to the people by providing an alternative to the processed food that dominates his world. The game and the film were created in partnership with Academy Award–winning Moonbot Studios and CAA Marketing, a division of Creative Artists Agency.


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A 42-year-old Milwaukee man allegedly almost choked his girlfriend into unconsciousness after she told him she wanted to visit her parents.
Romel Scott was charged on Wednesday, Aug. 27, in Waukesha County Circuit Court with strangulation and suffocation, false imprisonment, misdemeanor battery, intimidation of a victim and two counts of disorderly conduct.
Scott faces up to almost 14 years in prison and $42,000 in fines if convicted.
According to the criminal complaint, police responded on Monday, Aug. 25, to the victim's apartment complex near Summit road in Waukesha.
The victim told officers in the complaint that Scott had shoved her onto her bed and used his forearm to squeeze her neck until she nearly blacked out after she told him she wanted to go to her parents' house.
Scott then reportedly took her phone so his girlfriend couldn't call the police and chased her to her car when she tried to flee the apartment.
A neighbor heard the commotion, and saw Scott hit and push his girlfriend, and called police, according to the complaint.
Court records indicate that Scott is being held at the county jail on a $5,000 cash bond.
His preliminary hearing is scheduled for Thursday, Sept. 4.
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Beach Park Oceani Resort, Pindoretama
Situated on the beach in Aquiraz, Beach Park Oceani Resort is close to Beach Park Water Park, Porto das Dunas Beach, and Cofeco Beach. Additional area attractions include Park Engenhoca and Sabiaguaba Beach.
Resort Features.
Beach Park Oceani Resort has a water park, an outdoor pool, and a steam room. Public areas are equipped with wireless Internet access (surcharges apply). There is a business center on site. This beach resort offers a restaurant. Guests are served a complimentary breakfast each morning. Additional amenities include a children's club, a fitness center, and multilingual staff. Self parking is complimentary.
The 131 air-conditioned guestrooms at Beach Park Oceani Resort include minibars and safes. For a surcharge, guests can use the in-room wireless high-speed Internet access. Televisions are equipped with cable channels. Bathrooms offer hair dryers and complimentary toiletries. Housekeeping is offered daily.
Enter dates to check prices
Hotel Info: 866-539-8117from $85
- Standard Room
- Junior Suite (Double)
- Superior Room
Recommended hotels
At a glance
Key facts
Hotel size
- This hotel has 131 rooms
- This hotel is arranged over 3 floors
- Check-in time starts at 3 PM
- Check-out time is noon
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Parents must have child's birth certificate and photo ID *
- Babysitting/childcare
- Children's club
- Pets not allowed (service dogs only)
- WiFi in public areas *
- WiFi in rooms *
- Free self parking
- Area shuttle *
Nearby Three Star Pindoretama hotels
In the hotel
- Children's club
- Supervised childcare/activities
- Free buffet breakfast daily
- Restaurant
- 24-hour room service
- Beach sun loungers
- Beach towels
- Water park
- Outdoor pool
- Fitness facilities
- Tennis on site
- Steam room
- Surfing/boogie boarding nearby
- Windsurfing nearby
- Pool sun loungers
- Beach/pool umbrellas
- Business center
- 24-hour front desk
- Tours/ticket assistance
- Laundry facilities
- Number of buildings/towers - 1
- Year Built 1990
- Elevator/lift
- Safe-deposit box at front desk
- Accessible path of travel
- Accessible bathroom
- In-room accessibility
In the room
- Air conditioning
- Minibar
- Private bathroom
- Free toiletries
- Hair dryer
- Cable TV channels
- Desk
- WiFi (surcharge)
- Daily housekeeping
- In-room safe
Top Pindoretama hotels
Recently reviewed hotels in Pindoretama
- Eldorado Cafe
"I had a great stay in this small hotel. The friendly hotel stuff and their hospitality was super also the rooms are comfort and clean"Mar 8, 2015
- Sonata de IracemaFrom
"Great advise for foreigners mentioning safety rules for the area outside hotel. Proper English speaking employees in the hotel. Rooms were tidy and comfortable."Jan 5, 2015
- Holiday Inn FortalezaFrom
"Nice hotel overall"Nov 4, 2014
- Mareiro Hotel
"While the room was a bit underwhelming, they added a lot of nice touches. The view, access, breakfast, pool, and friendliness/helpfulness of the staff were all highlights."Sep 24, 2014
Beach Park Oceani Resort, Pindoretama's small print
Parents traveling with a child under 18 must present the child's birth certificate and photo ID (passport for foreign visitors) upon check-in. If only one parent or legal guardian is traveling with the child, that parent or legal guardian must also present a notarized consent of travel signed by both parents. Visitors who plan to travel with children should consult with a Brazilian consulate office prior to travel for further guidance.
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


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A band of travellers has moved into an Orpington gym car park.
The group reportedly turned up at the branch of LA Fitness, in Sandy Lane, yesterday (Monday July 14) afternoon.
There are around half a dozen caravans on the site, which is privately owned by a third party.
Jean Keal, 70, has been a member of LA Fitness for 14 years and said she is "horrified" by the situation.
She told News Shopper: "I followed a police car into the car park and saw the caravans. I was really shocked.
"I'm horrified - just the thought of them being in there. What will they do?
"They're taking up space in the car park. I don't know what state they'll leave it in.
"I'm not happy about it at all - I think people will stay away. Nobody will feel their cars are safe."
Another female gym member, who asked not to be named, told News Shopper: "I'm disgusted really.
"But I've seen it around here before - it's common in this area."
The deputy manager at LA Fitness declined to comment, but confirmed legal action is being undertaken.
Police, the landowner, the council, and the gym group are in discussions.
LA Fitness said: "We are working closely with the local police and council on this matter and obviously our priorities are with our staff and to ensure that our customers are not affected while this matter is being sorted with the landlord and the relevant authorities."
Bromley police said: "Police were made aware at around 12.54 on Monday July 14 that around 15 vehicles had set up in the grounds of the LA Fitness Centre in Sandy Lane.
"Officers have attended the site and are working with the council and landowners to resolve the matter."
Are you a member of LA Fitness, or a local resident? Get in touch with our newsroom on 01689 885725
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- UPDATE: Cyclist receives 'serious head injury' after crash in Greenwich Park
- Limited edition Marvel Avengers artwork goes on display at Bluewater


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Printable View
This is great no put downs yet!
I am just an odd ball... (or a 45 year old hipster), but still use some film, built my own sailboat, I do ride a single speed fixed gear bike from time to time, I don't drink enough to care or talk inteligently about what I drink, and lastly I do buy old $2 and $3 jazz albums to listen to on the Marantz. I CAN tell the difference between a MP3 file and analog recording (aside the clicks and pops).
I also consider myself an armchair economist. I do worry what global calamaty man-made or otherwise with put the economy further in the tank (who knows this might help film photography or NOT). The current upward blip in film use will either level off or fall off (I predict the later). I do think Ilford might be around the longest... and Adox and the other niche people will raise prices because of shrinking but devoted demand into the next decade.
PE might open a film coating business with his grand-kids sometime in the next decade.
I know there will be some interesting information to be had at this event, so well worth the effort to attend I reckon.
I don't see all this doom and gloom here at all. When I enter the Optics shop under my parent's house, I see the ordinary assortment of films. When I buy one (I bought some negatives there) they just give me the film, there is no chat about how rare it is to find people who uses film, that means it is not rare. Pretty much everywhere you can have your films developed by a commercial laboratory, be they slides or negative.
Last time I went to my "professional" laboratory to bring slides to develop (that must have been summer 2007) I asked them how business was going regarding film, and they told me it was going as strong as ever, they did not notice any sign of crisis (!).
When I go around taking pictures some film aficionado chats me up, but I never saw anybody "intrigued" by the use of a film camera, and I do see other people with film cameras around.
Film cameras are certainly more widespread than tripods, and nobody is fearing the end of the tripod industry. Looking into the future is hard. I have no crystal ball myself, but I would not bet at all on the end of film for the next 100 years. Certainly a restricted offer for some years, but the end, no, not at all.
Well I personally think that film, at least B&W, will outlive me. I mean, it becomes more and more prevalent to see people my age on here setting up their own darkroom, learning how to do the analouge stuff. The whole thing about hipsters is slightly true, but then again, its not just the hipsters. Digital makes sense for the people who want instant results (90% of the population), but for all the romanticists, nothing can beat the beauty of analouge. I personally will never buy a digital camera. If I can no longer shoot film, i will no longer shoot at all. If they do stop producing film, i will probably start coating my own. But i really think that B&W film will stick around. I believe that kodak will be down to like 2 or 3 B&W films, and 2 color films, there will still be many of the re-branded stuff (arista, etc.), but i think ilford will dominate the market, which is fine by me, they have the best films, in my opinion. Either way, i think film will still be around forever. Especially the large format, considering a 4x5 negative is equivalent to about 150 megapixels, and the cost is so incredibly small compared to a digital back, it's cheaper to buy a scanner and a ton of film. Anyways, look at how many users there are on here, almost 50,000 the counter says right now. So theres some proof that film will stick around, there will always be people like you and me. The day they stop making film will be the saddest day of my life.
The fact that there is little demand and high prices for enlargers and scanners, and silver gelatin paper doesn't help much either.
I wish people would give the 20-somethings, hipsters or not, a break. Support them, don't dis them. Be nice and encouraging. Some of them will tire of photography at some point and find other things that interest them, but some of them you'll meet on these forums eventually.
My 20's were a long time ago, but I was shooting film back then and I don't recall getting anything but encouragement from the other film shooters I ran into. That was pre-internet. Maybe people were nicer then?
People nowadays have more technological options than previous generations, and it's also the case that some new technologies are maturing. Somebody who grows up in this environment, or takes advantage of it, is a hipster.
A hipster is often a derogatory term for someone who is bold enough to take advantage of the vast technological options available to him. You can tell this because of the way the term is applied.
If a person indulges enthusiastically in the newest new technology (iPad, smart phones, bluetooth headset, twitter, etc) then they are not necessarily a hipster because people have historically used the latest technology and liked it, because it has always been better. To the older generations, it's a given that new technology will come out, and you will use it, and the old technology will become obsolete and become unavailable. So someone who uses the latest technology just because it's newer is not a hipster. There are lots of old people like this, and they aren't hipsters.
If a person indulges enthusiastically in old technology for some reason and avoids new technology, that person is just a luddite. There are lots of old people like this, and they aren't hipsters.
If a person looks around him, sees the largest amount of technological options available to him that have ever been available to a person in history, and uses or doesn't use those technological options according to his own whims and vision, or sometimes, fashion, that person is jealously labeled a hipster. Someone who wears canvas Vans(1980s technology) while tweeting on his iPad (2010 technology) with a Holga (20th century technology) around his neck while driving his SMART carb (2000s technology) to the skatepark to pick up some vinyl records (1930s-1980s technology) that he found on craigslist (1990s technology) can be called a hipster, because he lives in period which is a post-technology explosion. He doesn't use or wear the newest. He doesn't use or wear the oldest. He doesn't listen to or play the newest music or the oldest music based on some kind of generational allegiance. He does whatever he wants.
A hipster is usually young, because young adults are more flexible than old adults who are set in their ways, but they have more freedom than children who do what they see others doing.
The idea of a "hipster" is just a manifestation of generational jealousy. It's also evidence of a post-internet age, post Moore's law technological slowing.
In the 1980's CDs sounded the death knell for vinyl. A guy I know bought the last record pressing plant in Australia and established Corduroy Records. Everyone said he was mad. Then along came techno and DJs everywhere wanted to spin and scratch and mix it up. He couldn't keep up with demand, even though techno was his least favourite form of music. Something similar will happen to film.
Read 'The Long Tail' by Chris Anderson, former editor of Wired Magazine. This medium- the internet- allows people to sell to the tail, not just to the mainstream. Let the digi-folks have the mainstream. Retail shops have finite floor space and they have to cater to the mainstream. The film tail is wagging online with a whole lot of smaller companies, facilitated by internet distribution, doing reasonably well. Those with the imagination, like Nick at Corduroy Records, will go far in their niche, however tiny it is.


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Student Enrolment
We are now accepting online applications to our Archaeology, Conservation and Museum Studies Master's programmes for entry on 30 August 2015. Our application deadline is 1 May 2015. Please follow the 'Apply Now' link below to submit an application.
The application process for our Library Studies and Diploma programmes is currently closed and will open in early 2015.
Alan Williams
Visiting Researcher (2013)
Dr Alan Williams is an archaeometallurgist who works at The Wallace Collection, a national museum in London. He has been working on the metallurgy of medieval European armour and swords for many years. He holds a PhD in Archaeometallurgy from the University of Manchester, as well as a BSc in Chemistry.
Dr Williams is conducting research at UCL Qatar in collaboration with Professor Thilo Rehren, examining the metallurgy of Islamic swords. Many Islamic swords show a unique metallurgy, not paralleled in Europe, since they were made of crucible steel which could be manipulated to give patterned blades of the famous "Damascus Steel". In addition to conducting research, Dr Williams will contribute to teaching, primarily on the Archaeology of the Arab and Islamic World MA.


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Beautiful Countertops and Showers for less than you'd think!
2375 Foothill Blvd
Grants Pass, OR 97526
|MON 7:30am - 4:30pm
|TUE 7:30am - 4:30pm
|WED 7:30am - 4:30pm
|THURS 7:30am - 4:30pm
|FRI 7:30am - 4:30pm
|SAT 7:30am - 4:30pm
|SUN 7:30am - 4:30pm
Closed for lunch from 11:30 a.m. to 12:30 p.m.
Rogue Valley Marble of Grant Pass, OR has built a reputation for excellence with both contractors and homeowners. Our local plant manufactures affordable Cast Polymer products to be used in commercial and residential construction. A history of over 10 years in business has built a confidence in the high-quality of our products and installations.
We manufacture and install:
• Kitchen Counter Tops
• Custom Shower Pans & Walls
• Bathroom Tubs & Vanities
• Whirlpool Baths
• Handicap Accessible Showers & Seats
• Soap & Shampoo Shelves
• Window Wraps, Trim, and more
Our professional affiliations include ICPA, GWCMA, NHAB, NWSID, & ASID
We can assist you in any custom design. Give us a call today, and ask about our warranties!
Category: Room Ideas|Residential Cabinets and Countertops|Remodeling Contractors|Building Supplies|Bathroom Ideas|Stone|Kitchen Ideas|Tile Materials|Residential Stone|Disabled Products and Services|Home Countertops|Countertops
Serving: Grants Pass OR (Metro), Medford OR (Metro), Grants Pass OR
Specialty: Kitchen Remodeling, Bathroom Remodeling, House Additions
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Services: Customizing, Manufacturing
Details: Materials: Granite, Materials: Marble, Places: Kitchens, Assurances: Over 10 years of experience and great service
DexKnows Mobile profile for Rogue Valley Marble Inc in Grants Pass, OR