Acoustic emission(AE) characteristics of outburst coal samples are studied during the failure process in uniaxial compression under the stiffness test machine(MTS).The AE rate,ringdown-event ratio,cumulative counts,stress-strain levels,time and the relations among them are also analyzed.The results show that AE characteristics of coal samples depend strongly on different failure phases during the loading process of compressive tests,and the failure process is divided into five phases according to stress-strain curves and AE characteristics.The ringdown-event ratio is related to the change of energy in the coal,which represents the trend of AE curves during the failure process more accurately.So it can be used as one of the main forecasting parameters of coal and rock dynamic catastrophe.Elastoplastic phase(III) is the main phase,in which AE accumulative counts increase more,about 35.35% of its total counts.When the stress-strain curve is near the peak,the AE accumulative counts curve reaches a plateau,which means that there is a relatively inactive period of AE.The pre-peak relatively inactive period in other rocks also exists in the originally damaged coal,but the period of the damaged coal is shorter.The sharp increment of AE curves and the relatively inactive period before peaks can be seen as the symptoms of the coal peak value destruction to forecast the coal-gas-outburst in the coal mine.


Objective To observe the effects of Compound Danshen Dropping Pill(CDDP) and its components(Danshen,Salvia miltiorrhiza and Sanqi,Panax notoginseng) on electrocardiogram(ECG) in isolated hearts of guinea pigs to study its cardiotoxicity.Methods By using the Langendorff device for isolated hearts of guinea pigs,CDPP extract,Danshen extract(in Danshensu juice),and Sanqi extract(in ginsenoside Rg1) at different concentration(3,0.3,0.1,and 0.03 μg/mL) were perfused into the isolated hearts of guinea pigs,respectively,and then the changes of ECG in the isolated hearts were observed.Results CDPP extract and Danshen extract had no statistically significant changes of ECG.,while Sanqi extract at the low concentration induced no significant changes of ECG,but the dose of 3 μg/mL induced a significant change and weak increase of R-R and P-R intervals,and decreased heart rate(P 0.05).There was no significant effect of the three extracts on both QTc and Tp-cintervals.Conclusion CDPP and its components,Danshen and Sanqi at the tested concentration range,have no potential for delaying the ventricular repolarization or can not induce the severe arrhythmia in isolated hearts of guinea pigs.


Background and Aims: Global climate change can shift the distribution of infectious diseases. Europe has a number of distinct climatic regions with specific climate change vulnerabilities. The quan...


According to the idea based on humanity of industry design,this article explains the condition of the development from hospitality design to universal design. It analyses the conditions of the disable and the old as well as the design for them. It gives the concept of the universal design and explains its necessities and chief characteristics.


To improve the efficiency of an induction motor (IM), an algorithm has been developed in terms of slip frequency. A discrete-time multi-input and multi-output (MIMO) optimal regulator is proposed to achieve the desired speed with efficiency optimization. Furthermore, a full-order observer is proposed to estimate rotor flux and magnetizing current because these states of IM are feedback to design the proposed controller. The performances of the efficiency optimized speed control and observer system have been verified by simulation. Regarding the simulation study, it can be stated that the proposed controller and observer system are suitable for the implementation of efficiency optimized speed control of IM.


The present invention provides an electrostatic chuck that fixes a wafer by using electrostatic force and includes a base material; an adsorption layer that adsorbs the wafer; a bonding layer that bonds the adsorption layer to the base material; and a coating layer that is formed on an exposed surface of the bonding layer to prevent the erosion of the bonding layer, in which the coating layer that prevents the erosion of the bonding layer is formed by spraying non-heated ceramic powder to the exposed surface of the bonding layer. The present invention also provides a method for manufacturing an electrostatic chuck including (a) a step of forming a bonding layer by bonding an adsorption layer, which is formed of a ceramic sheet or an insulating resin sheet, to a base material; and (b) a step of forming a coating layer that prevents the erosion of the bonding layer on an exposed surface of the bonding layer.


An endo β-1, 3-glucanase was purified in crystalline form from a culture filtrate of Rhizopus chinensis R-69. Molecular weight of the enzyme was determined to be 23, 000 by molecular sieve chromatography and the mode of action of the enzyme was suggested to be a less random type of β-1, 3-glucanase. Km and Vmax of the enzyme for laminarin are 3.4g/liter and 154 I. U., respectively. The enzyme does not decompose the cell walls of living yeast; it decomposes, however, the preparation of yeast glucan.


Sediment runoff process in an actual small basin is discussed, based on the results of field survey and numerical analysis. In Nigorisawa river, a tributary of R. Mogami, a very active sediment runoff took place in June 1993 due to the erosion of debris produced by landslide. Numerical simulation is conducted in order to specify the sediment runoff and the characteristics of sediment movements along the river reach. The numerical results show that the flow discharge increases rapidly to a magnitude of several ten times of supplied water discharge due to the occurrence of debris flow, and the sediment transport rate and mode change from place to place according to the variation of bed slope and flow width.


This paper analyses the recent evolution of economic integration in South America, identifying the heterogeneous strategies that have been implemented. The analysis distinguished between issues that are a potential source for conflict, and issues where there exists a wider scope for achieving common objectives. Two levels of integration are considered: sub-regional (CAN and MERCOSUR) and multilateral (ALADI, CASA, ALABA). Each of these two types has different requirements as well as different aims. While the former involves deeper compromises, multilateral agreements have a more disperse agenda with less strict clauses. The different proposals are analysed from four perspectives: convergence of the agreements, integration in infrastructure and the development of regional goods, asymmetries and convergence, and institutional issues. The main conclusion is that countries involved in the integration process are far from fulfilling with a fundamental premise: to believe in what they agree and to agree in what they believe.


The study describes a targeted synthesis of a new dielectric material for an emerging ULTCC-I technology (ultralow temperature co-fired ceramic technology), which resulted in discovery of a PbTeV2O8 phase. A structural solution from powder data showed that the phase belongs to no known crystallographic family and is formed from V5+ ions in an unusual square-pyramidal coordination. It is characterized by very low processing temperatures that enable integration with Al electrodes and, potentially, even with polymer and paper substrates. Dielectric properties in combination with processing parameters qualify the PbTeV2O8 phase for integration, as midpermittivity capacitors, in ULTCC-I modules.


Virginia Wesleyan College, a small liberal arts college, recently conducted four major student satisfaction assessment projects. In particular, the institution wanted to know how students evaluated their educational experiences and how they evaluated college programs and services. The assessment projects, conducted during the 1991-92 and 1992-93 academic years included graduate follow-up surveys, non-returning student surveys, assessment of the college environment by an external team of consultants, and administration of the College Student Experiences Cuestionnaire. Results indicated that students, non-returning students, and graduates were generally satisfied with their educational experiences and with programs and services at the college. However, findings also revealed several areas of dissatisfaction. The graduate follow-up survey indicated that students were dissatisfied with registration processes, computer availability, library services, rules and regulations, career planning and placement services, food quality, the freshman seminar, cost of attending the college, and lack of financial aid resources. The evaluation by the external team which interviewed students found that students valued the small, caring atmosphere of the campus but were dissatisfied with the cost of attending, rules and regulations, communication with the administration, and other quality of life issues. Includes seven tables. (JB) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. **********************************************************************


The necessity and feasiblity are related about fixing circlet on the locomotive wheelset-rim in this paper.Three-dimension parameters entity model of the wheelset is established by using software SOLIDWORKS and it's mechanics-action is analysed before-and-after fixing circlet on the locomotive wheelset-rim using universal finite element software ANSYS8.0,wheel stresses are calculated and compared each other.The results indicate that the maximum stress on the wheel is all less than the yield stress,and it also prove that the influence to the wheel's structural intensity is limited,the safety factor is large enough.


A multiple signal conversion process has been observed in ferrimagnetic materials at microwave frequencies. The second harmonic of the input frequency is generated in a magnetized ferrite and caused to mix with the fundamental frequency in the specimen generating the harmonic. A portion of the upper side band power arising from mixing of the fundamental frequency and its second harmonic is constructively added to the third harmonic occurring from harmonic generation. The total output power at the third harmonic is consequently increased.


General Chairman of KOY KOOP Yakup Yildizreports "'Our Milk Factory Project has been accepted on July15th,2013 thus the contract period has started. Creamy yoghurt,cottage yoghurt, soft white cheese, kasseri cheese, butter, creamand ayran will be produced in our new milk facility funded byIPARD. ""GMO, genetically modified seeds are either served ashuman food or feeding.""We have never stored the milk in plastic containers since2003. Anyone may investigate and observe this in the villages.Carrying containers are made of 100% rustproof chrome nickel.Milk arrives at milk collecting center in half an hour aftermilking hence bacteria is not generated in cold environment. ""The sustainability is quite significant. The base price of oneliter milk in Burdur is 1 TL, cooling cost is 0,3 TL and support is0,9 TL, 1,12 TL in total. This price is almost the same with theprime cost.""As I know there are 3 or 4 types of milk production.Certainly the milk coming from the cow is unique however; firstlythere is hot milk then cool raw milk, thirdly farm milk and lastlystreet milk. To increase all these producted milk types to a highquality level is our misson. ""Cooperations are founded under Law No. 1163. 2012 wasthe year of World Cooperatives and I had many expectations lastyear. Although the prime minister has declared the CooperativesAction Plan, I think it is still not ready to be applied. New Constitutionis considered nowadays however we are not sure about thesituation of the cooperatives launched under the law No. 1163; itis still uncertain what will happen to farmer organizations."


Procrastination constitutes a self-regulatory failure which conveys many negative effects at an academic level. We analyze time managing values as a predictor of procrastination, studying a sample of 494 Colombian students of first year of University. We gathered information about the frequency with which they postpone tasks and about their time management behaviors using the Time Management Behavior Questionnaire (TMBQ). After building a logistic regression model, the "establishment of objectives and priorities" scale's scores, added to those for perception of control over time, proved to be accurate predictors. This is not the case for time management tools or preferences for disorganization. Among demographics (sex, age and dedication), the condition of students who have a shared dedication to job and studies plays a relevant role.


A vast class of disordered conducting-insulating compounds close to the percolation threshold is characterized by nonuniversal values of transport critical exponents. The lack of universality implies that critical indexes may depend on material properties such as the particular microstructure or the nature of the constituents, and that in principle they can be influenced by suitable applied perturbations leading to important informations about the origin of nonuniversality. Here we show that in RuO$_2$-glass composites the nonuniversal exponent can be modulated by an applied mechanical strain, signaled by a logarithmic divergence of the piezoresistive response at the percolation threshold. We interpret this phenomenon as being due to a tunneling-distance dependence of the transport exponent, supporting therefore a theory of transport nonuniversality proposed some years ago.


With improved creep resistance, fused quartz article such as a muffle tube or crucible. Creep resistance improvement of a result of controlling the devitrification of fused silica article. Control of devitrification, barium, strontium, is accomplished by coating the article with a colloidal silica slurry doped with metal cations such as calcium. Metal cations in the slurry, to promote the nucleation and growth of cristobalite crystals into fused silica at a temperature in the range of about 1000 ° C. ~ about 1600 ° C.. Cristobalite is significantly higher viscosity than the fused silica, thus a high creep resistance at high temperatures. Method for improving the creep resistance of the methods and fused silica articles of applying doped film on fused quartz article is also disclosed.


The significance of the introduction of modern computer technology to design, analysis, operation and control of sewer systems during rain is analyzed. With new tools come new basic concepts and new engineering criteria for performance. The most significant developments are: the capability to calculate surcharging and flooding, rather than just relating to pipe capacity performance criteria; the capability of calculating long series of rain record in order to derive proper statistics on the pollutional load on the environment; and finally the capability of dynamically controlling the system in real time in order to decrease the pollutional load by optimization of the usage of storage at rains smaller than the design rain, without increasing the risk of floods. INTRODUCTION The Romans were able to build and manage impressive hydraulic systems, in spite of a number of hydraulic misconceptions. These included structures for the drainage of comprehensive sewerage which was a new concept derived from the need to avoid epidemics of water borne diseases, not a structural innovation. However, the knowledge of basic hydraulics has improved significantly since the Romans. In fact, through the remainder of last century the basic concepts for the design of urban sewers developed into design procedures that stood the test of time and practice until only two decades ago, when the modern computer technology introduced entirely new possibilities. We are still grappling with the new tools in the process of establishing the lasting concepts on which to base new standards of practice for the design and operation of urban sewer systems. THE FUNDAMENTAL PROBLEMS: FLOODS AND POLLUTION Notwithstanding the whole spectrum of hydrological problems related to the development of the modern city it is clear from history and the present situation, that two problems supersede all others: Floods and pollution. Most cities situated at rivers and estuaries are prone to occasional inundation by floods, most of which are caused by the external hydrological conditions of the river and estuary rather than the urban drainage system per se. These external conditions are outside the scope of this paper, except as a downstream boundary condition, with respect to which several errors in design have been seen in practice. The real reason for the impressive investments in sewerage in European cities in the


Benign prostatic hyperplasia (BPH) is a common condition affecting middle aged and elderly men. Though BPH is not life threatening, its clinical manifestations affect the quality of life of the patients considerably. The symptoms of BPH include increased urinary frequency, urgency, hesitancy, slow stream, nocturia. The enlarged gland contributes to the lower urinary tract symptoms (LUTS). With time, these symptoms of incomplete emptying may lead to chronic bladder over-distension. ABSTRACT


The maize production status and germplasm basic of main popularized hybrids in Hebei Province are analyzed,the problems in maize production are pointed out,and the solving methods are put forward to provide reference for promoting the development of maize production.


In this paper we present the ConlluEditor annotation tool for manual annotation of files in CoNLL-U format, such as Universal Dependencies treebanks. Apart from providing a graphical editor for basic and enhanced dependencies, multi-token words, it also runs validation scripts to find potential errors. ConlluEditor uses a client-server architecture. It is freely-available under the 3-Clause BSD License.


cells of even normal populations, this method represents a practical and useful screening tool. However, it should be noted that urine cytology positive for decoy cells does not always indicate the presence of plasma BK virus DNA, and thus careful follow-up is needed for patients who have undergone kidney transplantation. In the present study, we observed a maximum DNA value of 10 000 copies/mL in the four patients with plasma BK virus DNA. Given that the virus is present in detectable levels in nearly 100% of all cases of BKVN, demonstration of BK viremia by quantitative real-time PCR is a reliable test for nephritis, particularly in cases of 10 000 copies of DNA/mL. Further, quantitative real-time PCR may be useful in evaluating the therapeutic effects of immunosuppressant reduction. At present, no patients on whom we conducted quantitative real-time PCR following detection of plasma BK virus DNA (Patients 2, 3, 4, and 5) have experienced acute rejection. In conclusion, early diagnosis of BKV infection with reduction of immunosuppression may counter BK viremia and retard progression of BKV nephropathy. Decoy cell screening by urine cytology and diagnosis and follow-up by plasma BK virus DNA detection should be considered in kidney transplant recipients, particularly in those with impaired graft function.


Effects of solution pH and molecular oxygen on the quantum yields of methylene blue-sensitized photolysis of diazonium salt have been studied in aqueous solutions, using thioacetamide as an activator. The quantum yield increased with an increase in pH when other parameters were kept constant. The presence of oxygen at pH ( 7) dominance of the pathway of oxygen quenching of the excited dye triplet caused its suppression. The polymerization of acrylamide in the deaerated solution was readily initiated by dye-sensitized photolysis. A mechanism involving an electron transfer to diazonium cation from unprotonated semimethylene blue formed by a photoredox reaction between excited triplet dye and thioacetamide was in line with these observation.


Two cases of perforated choledochus cyst are presented and the literature reviewed. One patient also had cysts of both hepatic ducts and the other hab been followed up for 14 years.


In this research, it was aimed to open the black box of disabled employment decisions, in order to increase inclusiveness among entrepreneurs and owners. This research used the founder identity theory by Fauchart and Gruber (2011) and was done by an analysis of field data. Eleven founders and owners in the hospitality sector in the Netherlands participated in this research. The main results are, first, that the moment of inclusion is essential. Second, the basic social motivation to start a firm is related to including disabled. Meaning, there are different types of entrepreneurs and that every type needs a different approach in order to stimulate inclusiveness. The first type started their firm because of personal interest and is not likely to include disabled. Therefore, the importance of inclusiveness should be taught, before starting a firm. Secondly, the entrepreneurs who are willing to include disabled should be pointed there are disabled people in their environment who want a job. By applying these two new approaches, inclusiveness should increase. This thesis contributes to the founder identity, it assesses whether it has an impact on entrepreneurs behaviour and whether entrepreneur's and owner's behaviour can be explained by their founder identity. Lastly, this research provides new insights on inclusiveness among entrepreneurs and owners.


Much has been said and written in the past few years regarding color management in general, as well as specific color management systems offered from a variety of vendors. However, considerably less attention has been paid to how these individual color management systems interact and work together in a system that includes applications, drivers, and printers with their own color management capabilities. This paper describes such a system architecture. In addition, support for color rendering intents in PostScript is discussed.


The desert sand concrete is less used in practical engineering because of its workability.Through the orthogonal experiment,the article analyses effect of the water-binder ratio、the tenggeli desert sand dosage,fly ash dosage and sand ratio on the 28d-compressive strength and workability.Considered the compressive strength and slump,the optimum proportion was A4B4C4D3,namely,the water-binder ratio of 0.40,sand rate of 32%,the tenggeli desert sand dosage of 25%,fly ash dosage of 15%.The tenggeli desert sand as fine aggregate in concrete is able to meet the need of the compressive strength and workability.


For a construction of the opto-electronic current transformer the effect of rotating of the photon echo (PE) polarization vector is offered. As an active ambience allowing get the photon echo the vapors of molecular iodine are used. The theoretical model of the opto-electronic current transformer (OECT) is discussed. The explanatory graphs of the n echo polarization vector rotating effect, as well as the principle scheme of the current measurement, are shown in the paper.


The use of several biomarkers of exposure for monitoring a treated mixed effluent from the Latrobe Valley Ocean Outfall was examined. Sand flatheads (Platycephalus bassensis) were exposed in the laboratory to two dilutions of effluent (1.3 and 2.5%, v/v) for three days. Cytochrome P450 content, 7-ethoxyresorufin-O-deethylase (EROD) activity, and biliary metabolites of polycyclic aromatic hydrocarbons (PAH), 2-chlorosyringaldehyde and 2,6-dichlorosyringaldehyde, were measured. There were no statistically significant differences in cytochrome P450 content or EROD activity between control and exposed fish. Analysis of the bile by gas chromatography/mass spectrometry of fish exposed to 2.5% effluent found no increases above background in the levels of PAHs, or specific chlorinated phenolics that are found in bleached hardwood pulp effluents.


Abstract Forcipomyia altaica, a boreo-montane species known previously only from the Altai Mts (Russian Central Asia), Czech Republic and Germany, is reported from the Italian Alps and Poland for the first time. Illustrated descriptions of both sexes are provided.


Recent excavations of Kory tombs at Locality A of the Chung-ri site in Sangju. Ky ngsangbuk-do Province, unearthed a number of celadons of early type. presumably dated earlier than the 12th century. as well as a variant of celadon with greenish color called nokch ngja (綠靑磁). The purpose of this paper is to identify the stylistic characteristics of those finds and to establish the proper chronological order of sequence. The materials for this analysis consist of 55 celadons. 1 white porcelain. and 7 pieces of earthenware. Most of them are bottles, dishes, bowls, and basins (wan 碗) with the halo-shaped design on the bottom called haemurigup. They are classified in several types and then arranged in a chronological sequence by applying the seriation method and comparing them with the materials from other sites. The sequence thus revealed consists of: earthenware type Ⅰ: haemurigup wan. bowl type Ⅰ:, celadon bottle type Ⅰ-1. bowl with foliated rim: bowl type Ⅱ-1, dish: bowl type Ⅱ-2, celadon bottle type Ⅰ-2: bowl type Ⅲ-1, bottle with underglaze iron: bowl Ⅲ-2. By comparison with the materials from other sites each of them are dated: earthenware from the mid-9th to the early 10th centuries: haemurigup wan from the late 9th to the early 11th centuries: celadon bottle type Ⅰ-1, bowl with foliated rim from the late 9th to the mid-10th centuries: bowl type Ⅱ and Ⅲ, dish, and celadon bottle type Ⅰ-2 from the late 10th to the late 11th centuries. These dates corresponds well with the result from the seriation.


Degenerate four-wave mixing (DFWM) spectroscopy is a potentially powerful technique for quantitative measurement of minor species in gas-phase media [1-3]. In this paper we compare the DFWM signal levels and lineshapes obtained using two different phase-matching geometries: the phase-conjugate geometry and the forward phase-matched geometry. DFWM signal levels are calculated by solving the time-dependent density matrix equations using direct numerical integration (DNI) [4, 5] for a two-level system interacting with three laser beams. This numerical analysis includes the effects of molecular motion, intermolecular collisions, and high laser intensities, all of which have been shown to affect the DFWM signal level.


Publisher rights © Copyright The Authors Authors of the systematic reviews on the EPPI-Centre website (http://eppi.ioe.ac.uk/) hold the copyright for the text of their reviews. The EPPICentre owns the copyright for all material on the website it has developed, including the contents of the databases, manuals, and keywording and data extraction systems. The centre and authors give permission for users of the site to display and print the contents of the site for their own non-commercial use, providing that the materials are not modified, copyright and other proprietary notices contained in the materials are retained, and the source of the material is cited clearly following the citation details provided. Otherwise users are not permitted to duplicate, reproduce, re-publish, distribute, or store material from this website without express written permission.


ABSTRACT  A VOLUNTEER ARMENIAN DETACHMENT IN THE BULGARIAN ARMY DURING THE FIRST BALKAN WAR  The Balkan war caused the Ottoman Empire loosing nearly the whole territory in Europe and great prestige as well. After the Armenian revolts during the period of Abdiilhamid II, some Armenians migrated to Bulgaria and approximately 300 Armenians had a part in the side of the Bulgarian army as a volunteer detachment in the First Balkan War. This volunteer detachment was under the command of General Geneff who was commanding the Volunteer Macedonian-Edime Brigade of 16.000 soldiers which consisted of Bulgarian and Macedonian irregulars. In this essay, the activities of the Volunteer Armenian Derachmenr have been examined d11ring the First Balkan war. Key Words: The First Balkan War, Bulgaria, the Ottoman Empire, Antranik, Volunteer Armenian Detachment


The intent of this paper is to describe a test program conducted at the ABSG Consulting, Inc. (ABS Consulting) shock tube research facility in San Antonio, Texas, where cable supported polycarbonate shield systems where tested to determine their viability as a curtain wall retrofit option. A total of five tests, using three different window systems, were tested to assess the capacity of each shield retrofit installed on the interior of an existing glazing panel. As a complement to the testing, high-fidelity numerical modeling was performed using the explicit finite element code LS-DYNA. The computational models were developed initially to establish the expected performance of the design. Additional testing was performed once the mechanism of failure was understood. Subsequent modeling was used to calibrate the tested system. The test program indicated a viable curtain wall retrofit system using a cable-polycarbonate shield. Information related to the test setup and observations from the program will be described. Details related to the modeling including material definitions, element formulations, boundary conditions, applied loading, and response predictions will be included. Finally, a comparison will be provided that illustrates the validity of numerical models with respect to the testing.


Background: Antenatal care in India is rising due to improvement in awareness; still few congenital malformations can be missed in routine check-ups. One lost baby due to birth defects raises questions like; did the malformation led to death, what was the exact nature of malformation, will it recur in next pregnancy and are there any preventive measures? Few congenital malformations can be diagnosed prenatally with ultrasonography techniques, various maternal serum assays, confirmation relies on actual examination of the fetus or neonate. These techniques cannot identify large proportion of congenital malformations for which perinatal autopsy remains the gold standard investigation. The result of a perinatal autopsy may have broad impact, in that obstetrical, fetal, maternal, paternal, and familial conditions may be uncovered. Methods: The descriptive analytical study was carried out in Department of Pathology of a tertiary care hospital from June 2014 to May 2016 for detection of congenital malformations in fetal and early neonatal autopsies in 5 years. Conclusion: Despite advances in imaging such as antenatal ultrasonography and serology, perinatal autopsy is superior and continues to play an important role in diagnosing congenital malformations. The findings of autopsy are not only of theoretical importance but also of practical significance to clinicians in the form of estimating the risk of recurrence and in genetic counseling. DOI: 10.21276/APALM.1272


We experimentally demonstrate Berkeley surface-emitting lasers (BerkSELs) from open-Dirac cavities. BerkSELs exploit symmetry-dependent scaling of losses in cavities with a linear dispersion and remain single-mode even as the cavity size increases.


Based on the event of single-warship air defence system intercepting several groups of target,the operational capability of air defense system with the improved AAM model is evaluated. In this model, a new concept of reready ability is put forward,and is used to,evaluate the course of continuous combating.The essential of air defense system can be reflected by this model,and the effect of reready ability is proved.


The influences of different Ce contents on the microstructures of as-cast and heat treated AZ61 magnesium alloys were investigated.The results showed that,with the Ce addition, the content of β phase was reduced,and the grain size of as-cast AZ61 alloy was refined remarkably.The Ce element mainly distributed by high thermal stable Al_3Ce compound.After solid-solution treatment,the β phase was completely dissolved into the matrix,whereas the Al_3Ce phase was still distributed at the grain boundaries as needle-like or rodlet grains.Based on the XRD,SEM and EDS results,and the Miedema model of mixed enthalpy,is because of the greater affinity between Ce and Al than that between Ce and Mg,is the formation of Al_3Ce phase in AZ61-Ce alloys.


This study investigates the correlation between students' causal attribution and English scores with qualitative and quantitative methods.There is no significant difference among students of various English proficient levels in the case of cause attribution but there is significance difference for learning failure in terms of learning environment,positive and negative opportunity,linguistic aptitude,and task complication.Learners' different orientations of the causal attribution of failure have a great effect on their learning behaviors,as well as achievement.


In this paper a new single-ended-input fully-balanced-output circuit (SFC) is proposed as an input interface for fully balanced signal processing systems. The new SFC can overcome the drawback of uncontrollable process variation of resistors and generate well-controlled process invariant common mode output voltage, V/sub 0, com/. The adopted active current common mode feedback compensation makes this possible. Simulations have been carried out using MOSIS 2 /spl mu/m N-well process and a 3 V supply, showing that with /spl plusmn/100% variation of resistor V/sub 0, com/ only varies by less than /spl plusmn/2%. In addition, it is shown that V/sub 0, com/ is accurately controlled by a preset DC voltage.


Multiple unmanned aerial vehicles (UAV) cooperative alliance combat is a new research problem. Through considering cooperative alliance's target value income index function, damage cost index function and voyage cost index function, the multi-UAV alliance cooperative game model is established in the paper, and its game matrix is structured. The definition of alliance characteristic function and mixed strategy Nash equilibrium are provided, the mixed strategy Nash equilibrium is obtained by using particle swarm optimization, and the cooperative game is solved by applying the method. At last, the feasibility and effectiveness of the method are presented by simulation results.


The Acid Rain Program of the Clean Air Act Amendments of 1990 (CAAA) authorized the US Environmental Protection Agency (EPA) to create an innovative system of tradeable SO{sub 2} emission allowances for affected electric utilities. The resulting system is unique in that it requires a partnership between EPA, electric utilities, the Federal Energy Regulatory Commission (FERC), state public utility commissions (PUCs), and state air-pollution control agencies to successfully meet SO{sub 2} reduction requirements.


This video discusses the clinical equivalence of BI 695501 (Cyltezo®; adalimumab-adbm) and adalimumab for rheumatoid arthritis - the VOLTAIRE-RA and extension studies.


Current models of dichotic listening do not predict whether linguistic word tones would be perceived more accurately by the right or the left ear. In this experiment five Cantonese words, all having the segmental structure /ma/ but differing in tone, were presented dichotically to two groups of Ss. One group consisted of right‐handed native speakers of Cantonese, the other of right‐handed native speakers of English. Ss in both groups were first trained to identify the tones using iconic tone letter symbols, and were then tested dichotically. Overall, there was a slight but nonsignificant left ear effect for both groups. In the Cantonese group, four Ss showed a left ear effect, and three showed a right ear advantage. In the English group, three Ss showed a slight right ear effect, three Ss a left ear effect, and one S no ear differences at all. These results suggest that individual subjects are probably using somewhat different strategies in identifying lexical tones, and would not support claims that tona...


Against to the importance of highway intersection design,three highway intersection designs with assistant road methods were proposed.Their merits and drawbacks were analyzed so as to accumulate highway intersection with assistant road design experience and enhance road designer's design level.


Using the Thermodynamic Formalism, we introduce a Gibbsian model for the identification of regular grammars based only on positive evidence. This model mimics the natural language acquisition procedure driven by prosody which is here represented by the thermodynamical potential. The statistical question we face is how to estimate the incidenc e matrix of a subshift of finite type from a sample produced by a Gibbs state whose potential is known. The model acquaints for both the robustness of t he language acquisition procedure and language changes. The probabilistic appr oach we use avoids invoking ad-hoc restrictions as Berwick's Subset Principle.


Feeding practices among vulnerable newborns in Vietnam: a preand post-evaluation of integrating a human milk bank into newborn care services


AbstractIn this article, the results of an international survey on Sustainable Development (SD) as an aspect of business management are presented. 95 companies, listed in internationally known indices, are evaluated based on homepages and sustainability reports concerning their integration of ecological and social aspects as well as a super-ordinate "generic" dimension. The analysis has been made to find out specific regional trends and variations between industries on the implementation of SD aspects. Distinct regional differences could be distinguished concerning emphasis being put on the SD dimensions. Apart from regional differences also (enormous) industry-typical variations became obvious concerning SD as aspect of the management.


Children with atopic dermatitis — especially moderate-to-severe disease — seem to have an risk of developing other atopic diseases, such as asthma, allergic rhinitis and food allergies, says this expert.


This article focuses on the proposed merger of Canadian Pacific and Norfolk Southern and the potential outcomes of the merger. The author discusses the importance of empowering short lines and regional connections. He also discusses the need for a removal of paper barriers and the merger's possible impact on competition.


For the unsymmetrical title compound, 1-bromo-1′-[(2S)-N-(1-hydroxy-3-methylbutane-2-yl)]-ferroceneamide, two independent molecules were found in the asymmetric unit. Copyright © 2003 John Wiley & Sons, Ltd.


Pediatric malignancies, in particular Ewing sarcoma (EwS), are characterized by low mutational load, low immunogenicity, and early metastasis. They recapitulate the embryonic immune tolerance setting and remain a challenge for established immunotherapies. These immunotherapies are not sufficient to target metastasis. Ideally, targeted therapies address gene products required for metastasis. We completed in vivo functional analyses for metastasis of 9/37 genes that we had shown to be overexpressed in EwS (Staege at al., Cancer Res 2004) and generated HLA class I restricted cytotoxic T cells against these gene products. All targets were involved in fetal development and 8/9 demonstrated functional relevance for metastasis. Allorepertoire-derived TCRs against 8/9 targets were cloned and sequenced; one target (DKK2) was nonimmunogenic. 7/8 TCRs were crossreactive, caused fratricide, or clonal TCR expansion failed (EZH2, STEAP1, PAPP-A, GPR64, ADRB3, LIPI, HOX-D1). In the tumor microenvironment we found an immunosuppressive (M0 and M2) transcriptomic signature and evidence for an immunosuppressive inflammation-associated activation of endogenous retroviral sequences. Among these most selectively expressed (n=9) and metastasis sustaining (n=8) targets, the BRICHOS chaperon domain containing antiangiogenetic bone protein chondromodulin-I (CHM1) was addressable by a non-crossreactive TCR. CHM1 is a direct downstream target of the oncogenic driver EWS-FLI1. We clinically assessed HLAA* 02:01/CHM1-specific TCR transgenic CD8+ T cells against EwS utilizing a TCR complementary determining region 3 (CDR3) recognition-sequence for the CHM1319 peptide with a Koff half-life of 113.2 ± 38.2 s. The CHM1319 motive was 130 times less homologous as compared to the 9mer ADRB3CHM1295, a crossreactive EwS target identified before. Four refractory HLA-A2+ EwS patients (pts) were treated with CHM1319-specific TCR-CDR3 transgenic T cells. Pt-derived cell lines (PDCL) were established in all cases. Pts received up to 107/kg TCR transgenic CD8+ T cells. All pts were treated with the same TCR-CDR3 recognition-sequence for CHM1. All PDCLs displayed persistent HLA-A2 expression. Transgenic T cells showed specific in vitro lysis of all PDCLs. Therapy was well tolerated and did not cause graft-versus-host disease (GvHD). Pts #1 #3 and #4 showed delayed progression, whereas pt #2, while having bone marrow (BM) involvement and accessible multifocal disease, showed partial metastatic regression associated with T-cell homing to involved lesions. In conclusion, CHM1319-TCR transgenic T cells may home to affected BM and may cause partial remission. CHM1-TCR transgenic T cells address a persistently expressed target required for metastasis, suggesting lack of immunoediting selection pressure. They proliferate in vivo without causing GvHD. This abstract is also being presented as Poster A07. Citation Format: Stefan Burdach, Guenther Richter, David Schirmer, Andreas Kirschner, Sebastian Schober, Valentina Evdokimova, Hendrik Gassmann, Elvira D'Ippolito, Maxim Barenboim, Dirk Busch, Poul Sorensen, Uwe Thiel. T-cell receptor (TCR)-based immunotherapy in pediatric malignancy: Addressing the challenge of early metastasis and low immunogenicity [abstract]. In: Proceedings of the AACR Special Conference on the Advances in Pediatric Cancer Research; 2019 Sep 17-20; Montreal, QC, Canada. Philadelphia (PA): AACR; Cancer Res 2020;80(14 Suppl):Abstract nr PR05.


Nuclear factor kappa B (NFkB) is a transcription factor that resides in the cytoplasm of every cell and translocates to the nucleus when activated. Its activation is induced by a wide variety of agents including stress, cigarette smoke, viruses, bacteria, inflammatory stimuli, cytokines, free radicals, carcinogens, tumor promoters and endotoxins. On activation, NFkB regulates the expression of almost 400 different genes, which include enzymes (COX-2 and iNOS) cytokines (TNF, IL-1, IL-6,IL-8 and chemokines),adhesion molecules, cell cycle regulatory molecules, viral proteins and angiogenic factors. NFkB has been linked with a wide variety of human diseases, including asthma, atherosclerosis, AIDS and diabetes, alzheimer's disease and cancer. NFkB transcription factors and the signaling pathways that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NFkB signaling also has a critical role in cancer development and progression. The purpose of this review is to describe what is known about the molecular biology of NFkB and to review information that implicates NFkB in the pathogenesis of human diseases.


Biofabrication strategies continue to gain considerable interest in the efforts to develop methods for better replicating in vitro models of human tissues [...].


From the end of the last century several innovators have been exploring the use of seismic land streamers for the acquisition of seismic data with mobile systems. Nowadays, the technological development of these streamers is at such a point that it can be considered alternative to traditional geophones, with temporal and economic advantages in survey acquisition. Similar alternatives have also been partially developed for the acquisition of geoelectrical data with mobile systems. However, these last systems suffer from depth limitations given the difficulties in establishing proper electric contact with the ground. An appropriate streamer combining these two geophysical methodologies is currently not available. For a reliable and comprehensive soil characterization, the combined use of different geophysical parameters is suggested. In this paper, the authors therefore investigate the possibility of improving a standard seismic streamer using appropriate tools for performing combined geoelectrical acquisitions. Preliminary results with the newly developed instrumentation for geoelectrical measurements are presented. An application to a case history for the geotechnical characterization of a river embankment, combining seismic and geoelectrical surveys, is also reported. Benefits of the combination of the two survey systems in a single streamer are also briefly discussed.


It has been the general experience in the clinical laboratory that the preparation of a proper colloidal gold solution, that is, a solution which will prove ideal for carrying out the colloidal gold test as applied to the differentiation of cerebrospinal syphilis, is often fraught with certain difficulties frequently not under the control of the worker. With due regard for the proper cleansing of glassware, the purity of the reagents entering into the preparation of such a solution and temperature precautions as laid down by those 1 who have investigated the nature of colloid chemistry as highly necessary prerequisites for the achievement of a good product, it is not infrequently found that such solutions thus prepared are far from being suitable, if not altogether unsuitable, for the test proper. Excluding those colloidal gold solutions that are grossly bad or self-condemnatory by their physical appearances, that is, either turbid or of


The vagus nerve, the primary neural pathway mediating brain-body interactions, plays an essential role in transmitting bodily signals to the brain. Despite its significance, our understanding of the detailed organization and functionality of vagal afferent projections remains incomplete. In this study, we utilized manganese-enhanced magnetic resonance imaging (MEMRI) as a non-invasive method for tracing vagal nerve projections to the brainstem in vivo and assessing their functional dependence on cervical vagus nerve stimulation (VNS). Manganese chloride solution was injected into the nodose ganglion of rats, and T1-weighted MRI scans were performed 12 and 24 hours post-injection. Our findings reveal that vagal afferent neurons can uptake and transport manganese ions, serving as a surrogate for calcium ions, to the nucleus tractus solitarius (NTS) in the brainstem. In the absence of VNS, we observed significant contrast enhancements of around 19 to 24% in the NTS ipsilateral to the injection side. Application of VNS for four hours further promoted nerve activity, leading to greater contrast enhancements of 40 to 43% in the NTS. These results underline the potential of MEMRI for high-resolution, activity-dependent tracing of vagal afferents, providing a valuable tool for the structural and functional assessment of the vagus nerve and its influence on brain activity.


Introduction: Natural killer (NK) cells are important part of the innate immunity defense system and play an antiviral, anti-tumor and immunomodulatory role in the body's immune response. NK cells are the first lymphocytes recovered after umbilical cord blood transplantation (UCBT). By attacking on the host cell, leukemia cells and antigen-presenting cells, the allogeneic reactive NK cells help realize successful implantation, mediate Graft-versus-leukemia (GVL) to reduce the recurrence, and lower the incidence of graft versus host disease (GVHD) respectively, thereby improving overall survival (OS) ultimately. The effect is based on the interaction of killer-cell immunoglobulin-like receptors (KIR) of donor NK cells with ligands of the major histocompatibility complex found on the surface of the target cells. HLA-C1 subtypes provide the ligand for KIR2DL2 and KIR2DL3, and the HLA-C2 subtypes for KIR2DL1. Therefore, we want to study the impact of the killer cell immunoglobulin like receptor/human leukocyte antigen(KIR/HLA) receptor ligand model in UCBT
 Method: Between July 2012 and June 2018, 270 patients with malignant hematologic disease receiving single-unit UCBT were divided into two groups based on the absence or the presence of one of the C-ligands for inhibitory KIR. Group 1 (n=174) patients lacked a C-ligand for inhibitory KIR present on UCB NK cells, (patients homozygous C1/C1 or C2/C2). Group 2 (n=96) patients had heterozygous C1/C2 in which KIR-mediated GVL effect was not expected (presence of both C ligands for inhibitory KIR in the receptor). Group 1 (mean age 13y, r 1-62; male 90) and group 2 (mean age 14.5y, r 1-59; male 56) had no significant differences in age, gender, weight, underline diseases, state of disease, and HLA match (low-resolution). All patients' conditioning regimen was myeloablative and did not contain anti-thymocyte globulin (ATG). Cyclosporine combined with mycophenolate mofetil was applied as GVHD prophylaxis.
 Results: The median follow-up time since the transplant for the surviving patients was 25 months (11-84 months). We compared some indicators related to UCBT between the two groups. The median time to neutrophil engraftment for group 1 and 2 was 16 days vs. 17 days (P = 0.705), and median time to platelet engraftment was 35 days vs.38.5 days (P = 0.317). The cumulative incidence of II-IV acute GVHD in 100 days was 42.5% (38.7% for group 1 vs. 50.0% for group 2, P = 0.0751), but multi-variate analysis showed that HLA-C ligand absence was an independent risk factor for II-IV acute GVHD after transplantation (HR=1.5280, P=0.0356). Patients with absence of a C-ligand for inhibitory KIRs (Group 1) showed a lower relapse rate than patients with both C-ligands (group 2):17.7% VS 22.7% at 3 years (P=0.288). The 3-year OS was 69.3% for group 1 and 60.5% for group 2 (P=0.0792). Non-relapse mortality for group 1 was 16.8% and for group 2 was 20.8% (P=0.328). There was no statistically significant difference between the two groups in 3-year disease-free survival (64.9% vs 55.4%, P=0.0819).
 Conclusion: Our results suggest that patients lacking a KIR-ligand of HLA group C1 or C2 had a lower incidence of grades II-IV acute GVHD after UCBT. The absence of HLA-C ligands in recipients had no statistically significant effect on other transplant survival prognosis, which may be related to the conditioning regimen without removing T cells. A beneficial impact mediated by NK alloreactivity between UCB and recipient may be observed during longer follow-up. Therefore, the absence of a C-ligand could be considered as one of the critical factors for the selection of UCBT.
 No conflict of interest to declare.

 No relevant conflicts of interest to declare.


(ProQuest: ... denotes non-US-ASCII text omitted.)Saints and Symposiasts: The Literature of Food and the Symposium in Greco-Roman and Early Christian Culture . By Jason Konig . Cambridge : Cambridge University Press , 2012. xi + 417 pp. $120.00 cloth.Book Reviews and NotesJason Konig succeeds at offering a truly magnificent feat. We encounter his understanding of the literary traditions of banqueting when he presents the works of Plutarch or Clement or Macrobius or many others. Konig reveals how they weave voices past and present, obscuring such distinctions. His encyclopedic thoroughness illustrates how these authors push the boundary between proliferation and control. Exploring this tension he draws upon the methodological work of Mikhail Bakhtin. As guests at this feast we experience this proliferation as well. Konig argues that others have "view[ed] the work of imperial-period authors as minor footnotes in the afterlife of the Platonic symposium tradition" (14), and he aims to correct this. His remarkable notes and bibliography match his ambition, offering current and key primary and secondary sources for these many varied texts. This book should be essential reading for anyone interested in meals, ancient narratives, or abundance and control.Konig explores these literary representations of meals and table talk over the course of twelve rich chapters divided into two major sections. In the first section he introduces imperial era literature related to dining traditions. Following his introduction, each chapter reveals his skillful reading of yet another author, yet another text: Plutarch; Athenaeus; a quick review of New Testament and earliest Christian contributions; Clement; Methodius; Augustine; Chrysostom; Julian; and Macrobius. He envelops the reader in particulars of meal customs while simultaneously invoking Plato, his symposium, and other earlier meals. He particularly highlights the blurred distinctions between past and present. Konig repeatedly illustrates how these ancient authors make a reader work to keep track of where one voice ends and another begins. Konig argues that "Athenaeus' editors have generally underestimated the importance of that fact in their eagerness to identify each speaking voice firmly" (109). In contrast, Konig reveals how voices from centuries apart may enter into dialogue with one another, "the sympotic setting thus allows Athenaeus to dissolve the time barriers of the past, allowing authors of very different times to speak together, albeit often in a rather precarious fashion" (106). He invokes Bakhtin to consider further what it means that they seem to speak to one another, explaining Bakhtin's "presentation of utterances which seem to blend two different voices, or to contain within them the marks of dialogue with some unnamed other--what he refers to as 'double-voiced speech'" (53). Konig finds this to be a suggestive model for thinking about sympotic narratives. He also argues that this focus reveals that later authors, especially Christian authors, move to a more monologic approach to table talk, perhaps signaling an interest in a less shared, more singular authority. …


The invention relates to a resin/graphene conductive plastic master as well as a blasting stripping preparation method thereof. The conductive plastic master batch consists of the following components in parts by weight: 10-30 parts of EVA (ethylene/vinyl acetate), 70-80 parts of graphite, 0.7-3 parts of a coupling agent, 0.1-2 parts of a surfactant, 0.2-0.8 part of paraffin and 0.1-0.4 part of an antioxidant. The preparation method comprises the following steps: extruding and pelletizing the components through a twin-screw extruder to obtain EVA/graphite small particles; then, heating water, the resin/graphite conductive master batches, a physical foaming agent and an isolating agent in a high-pressure kettle, and then quickly discharging under low pressure to obtain resin/graphene conductive plastic foamed master batch prepared by a blasting stripping method; and extruding and defoaming the conductive plastic foamed master batch through the twin-screw extruder to obtain the resin/graphene conductive plastic master batch. According to the method, the dissolving capacity of a supercritical physical foaming agent is sufficiently utilized, so that a graphite sheet layer can be stripped by expanding under a sudden pressure release condition when the supercritical physical foaming agent is penetrated into the graphite sheet layer. Due to the existence of the resin, the cluster of graphene is effectively blocked, and the obtained volume resistivity can be 0.005 Ohm.cm, so that the method is suitable for industrial production.


Messy Mountain Meandering Predicting the influence of climate on landscapes is sometimes straightforward; for example, river deposits might grow with increased rainfall because erosion rates and sediment transport increase. However, long-term tectonic processes complicate the geomorphic signatures of more gradual climate-related phenomena that reconfigure landscapes. By correlating a decades-long record of typhoon rainfall in Japan with digital elevation models, Stark et al. (p. 1497) show that climate directly influences the extent of river meandering. When expanded to a larger region of the western North Pacific, this analysis revealed a strong climatic imprint on the landscape of humid mountainous areas. The region-wide analysis also revealed that underlying bedrock strength, as opposed to tectonic uplift, acts as a secondary control. Typhoon frequency and bedrock strength influence river meandering in mountain environments. Climate controls landscape evolution, but quantitative signatures of climatic drivers have yet to be found in topography on a broad scale. Here we describe how a topographic signature of typhoon rainfall is recorded in the meandering of incising mountain rivers in the western North Pacific. Spatially averaged river sinuosity generated from digital elevation data peaks in the typhoon-dominated subtropics, where extreme rainfall and flood events are common, and decreases toward the equatorial tropics and mid-latitudes, where such extremes are rare. Once climatic trends are removed, the primary control on sinuosity is rock weakness. Our results indicate that the weakness of bedrock channel walls and their weakening by heavy rainfall together modulate rates of meander propagation and sinuosity development in incising rivers.


Abstract— Irradiation of daunomycin (or adriamycin) and the spin trap 5,5‐dimethyl‐l‐pyrroline‐1‐oxide (DMPO) at 490 nm in the presence or in the absence of air generated the hydroxyl radical adduct (DMPO‐OH). The observed DMPO‐OH signal was not affected by the addition of hydroxyl radical scavengers (ethanol, formate), suggesting that direct trapping of the hydroxyl radical was not involved. The DMPO‐OH signal was insensitive to superoxide dismutase and catalase, which ruled out the possibility of superoxide or H2O2 involvement. These findings demonstrate that daunomycin (or adriamycin) does not generate hydroxyl radicals or superoxide radical anions when subjected to 490‐nm excitation. However, when daunomycin (or adriamycin) was irradiated at 310 nm DMPO adducts derived from two carbon‐centered radicals, superoxide and the hydroxyl radical were detected. The superoxide adduct of DMPO was abolished by the addition of SOD, providing unequivocal evidence for the generation of the superoxide anion radical. The daunomycin semiquinone radical, observed upon 310‐nm irradiation of daunomycin in the absence of DMPO, appears to be the precursor of the superoxide radical anion. One of the carbon‐centered radicals trapped by DMPO exhibited a unique set of hyperfine parameters and was identified as an acyl radical. This suggests that the known photochemical deacylation of daunomycin occurs via a homolytic cleavage mechanism. The free radicals generated photolytically from adriamycin and daunomycin may be involved in the etiology of the skin ulceration and inflammation caused by these drugs. A knowledge of the dependence of these photogenerated radicals on the wavelength of excitation may be important in the development of adriamycin and daunomycin for photodynamic therapy.


The development of the State Pharmacopoeia of Ukraine (SPU) is based on the following principles: harmonization with the European Pharmacopoeia (EP); consideration of national specificity, self-sufficiency, National System of Pharmacopoeial Reference Standards (PhRS), feedback from users. For implementing the mentioned principles 4 main scientific areas of activity have been developed: proper elaboration of SPU texts, the National System of the PhRS, Proficiency Testing Scheme for medicines control laboratories (PTS), metrological support (in particular the validation of analytical procedures). The specificity of developing texts for SPU 1 (2001) and 2 editions (2016) have been analyzed for the following sections: general chapters, monographs for pharmaceutical substances, finished drug products, herbal medicinal products, compounded preparations, etc. The concept of further development of SPU has also been discussed.


This paper proposes a design of the racetrack microcavity resonator based on silicon substrate. The optimized dimensions of the structure were found by FDTD simulation. The characteristics were also found by the method, and further compared with another model of mode coupling theory. The optimized dimensions of straight guide at wavelength 1.55 /spl mu/m are thickness and width of 0.4 /spl mu/m. The curve guide provides the maximum at 1 /spl mu/m whereas the resonating section requires small coupling section of about 3 /spl mu/m.


This paper simply introduces the Application and development of arene side Chain fxidiation in fine organic Synthetie,It Chiefiy discusses about:The way that arene side chain can be oxidized Selectivizy to preparaate relevant alcohol aldhyd.Ketone and carboxy acid,egc;It also dcribse the direction of this kind of reaction in developing.


Nowadays, a major medical problem concerns the effective treatment of musculoskeletal disorders, especially in elderly patients. Implantable metallic materials have been widely applied in reconstructive medicine, including the field of orthopedics. Many studies have presented the beneficial effects of sol–gel-derived silica coatings in the preparation of bioactive materials, e.g. drug-eluting or mesoporous materials that stimulate tissue regeneration. In the current research, we have fabricated a sol–gel-derived silica coating functionalized with vitamin E for the reduction of oxidative stress (OS) on adipose-derived mesenchymal stem cells (AMSCs) isolated from elderly patients. Elevated levels of endogenous OS, through the mitochondrial secretion of reactive oxygen species (ROS) has an unquestionable impact on the viability and multipotent character of MSCs, which in consequence leads to the decreased therapeutic potential of engrafted cells. In the present study, we used a common antioxidant (vitamin E) and investigated its influence on AMSC proliferation and apoptosis at a concentration of 2% in a functionalized sol. The morphologies of the surfaces and coatings were determined using scanning electron microscopy (SEM), and their elemental composition was determined by SEM-EDX. The immobilization of ascorbic acid in the coatings was confirmed with Raman spectroscopy. Using RT-PCR and multiple cell imaging techniques, we evaluated the influence of the novel biomaterial on AMSCs. We have found that the biomaterial functionalized with vitamin E has a beneficial effect on cell viability and proliferative potential, as it decreased OS and induced the activity of free radical scavengers e.g. SOD in AMSCs.


A multi-messenger, black hole (BH)–neutron star (NS) merger event still remains to be detected. The tidal (dynamical) ejecta from such an event, thought to produce a kilonova, is concentrated in the equatorial plane and occupies only part of the whole azimuthal angle. In addition, recent simulations suggest that the outflow or wind from the post-merger remnant disk, presumably anisotropic, can be a major ejecta component responsible for a kilonova. For any ejecta whose photosphere shape deviates from the spherical symmetry, the electron scattering at the photosphere causes a net polarization in the kilonova light. Recent observational and theoretical polarization studies have been focused on the NS–NS merger kilonova AT2017gfo. We extend those works to the case of a BH–NS merger kilonova. We show that the degree of polarization at the first ∼1 hr can be up to ∼3% if a small amount (10−4 M⊙) of free neutrons have survived in the fastest component of the dynamical ejecta, whose beta-decay causes a precursor in the kilonova light. The polarization degree can be ∼0.6% if free neutrons survived in the fastest component of the disk wind. Future polarization detection of a kilonova will constrain the morphology and composition of the dominant ejecta component, therefore helping to identify the nature of the merger.


The rapid development of Information and Communication Technology (ICT) is more widely influencing all human beings, in professional and private lives. ICT and its applications are interacting with environments, roles, and processes of social and psychosocial change. New solutions for prolonging work ability and postponing aging through computer based learning and e-learning are opened. In this paper, it is argued that blended learning with computer based learning in the Moodle e-learning environment based on social constructivist learning theory is an effective tool for teaching and learning of occupational health and healthy workplaces discipline based on Ergonomic knowledge. The author has twelve years experience of computer based teaching for full time students and for students of distance learning. Students age is between nineteen and fifty-eight years. The author's own teaching experience of the Moodle e-learning environment for creating and providing different courses in the Tallinn University of Technology, will be presented. According to the questionnaires given more to 1000 students at the end of each course, the teaching and learning in the Moodle e-learning environment as blended learning is very useful for development of a learning culture in higher education. The effectiveness and motivation for learning are higher than providing traditional methods of learning. The high appreciation of e-learning in the Moodle e-learning environment is the same of students of all ages. E-learning in the Moodle e-learning environment is one of the very perspective solutions for lifelong learning. Keywords-Moodle; E-learning; Blended Learning; University Education; Convergence


The purpose of this study is to discuss two perspectives on rater-mediated assessments: psychometric and cognitive perspectives. In order to obtain high quality ratings in rater-mediated assessments, it is essential to be guided by both perspectives. It is also important that the specific models selected are congruent and complementary across perspectives. We discuss two measurement models based on Rasch measurement theory (Rasch, 1960, 1980) to represent the psychometric perspective, and we emphasize the Rater Accuracy Model (Engelhard, 1996, 2013). We build specific judgment models to reflect the cognitive perspective of rater scoring processes based on Brunswik's Lens model framework. We focus on differential rater functioning in our illustrative analyses. Raters who possess inconsistent perceptions may provide different ratings, and this may cause various types of inaccuracy. We use a data set that consists of the ratings of 20 operational raters and three experts of 100 essays written by Grade 7 students. Student essays were scored using an analytic rating rubric for two domains: (1) idea, development, organization, and cohesion; as well as (2) language usage and convention. Explicit consideration of both psychometric and cognitive perspectives has important implications for rater training and maintaining the quality of ratings obtained from human raters.


A facile and simple route for the direct preparation of substituted 3-methylcyclohex-2-enone via Aldol-Robinson cascade reaction of aldehydes and acetones catalyzed by the new catalytic system of L-lysine/imidazole in n-heptane with 0.5% water was reported. A variety of substrates can participate in the process efficiently. The merits of this method included inexpensive and easily available starting materials and catalyst, the good yield of products and the straightforward work-up.


The topic under discussion directs our attention to a major demographic shift unparalleled in moder history. We should note that Western Europe, Canada, and several developing countries are also attempting to deal with urban-to-rural migration and/or declining rates of rural-to-urban movements. So, we are observing a cross-cultural phenomenon of migratory decision making which is constrained by economic realities. Edward's paper addresses the applicability of economic models to the problems associated with rural employment and population shifts. His assertion that "we should sort on the cause and notice the effect" assumes that we have identified the problem, specified a conceptual model, and can properly measure the relationship between cause and effect. In reality, we often fail in one or more of these efforts. I prefer a problem-oriented focus which forces us to examine alternative dimensions of both cause and effect. From Dillman' s paper, I infer that the persistent value placed on rural over urban amenities has finally been recognized by corporate decision makers. Consequently, an increasing number of manufacturing plants are located in rural areas where production costs are lower, workers happier, and profits higher. By way of division of labor, I will be directing the balance of my comments to Hoch's paper. Hoch's topic was challenging, his concluding hypothesis stimulating, but his approach may be most useful in pointing to some limitations of data and modeling. I was frustrated in trying to come to grips with the theoretical underpinnings of his approach. While his paper reflects intimate familiarity with the broader issues, I fear that sufficient guidelines have not been provided to enable the reader to identify effectively and evaluate the basic information flowing from his analysis.


An antimalarial screen for plants collected from Papua New Guinea identified an extract of Horsfieldia spicata as having activity. Isolation of the active constituents led to the identification of two new compounds: myristicyclins A (1) and B (2). Both compounds are procyanidin-like congeners of myristinins lacking a pendant aromatic ring. Myristicyclin A was found to inhibit the ring, trophozoite, and schizont stages of Plasmodium falciparum at similar concentrations in the mid-μM range.


Blood glucose level can be checked from whole blood sample which is from capillary or venous, serum, and plasma blood vessel with anticoagulant of Sodium Fluoride (NaF), Na-oxalate, Na-citrate, or Lithium-heparin. Sodium Fluoride (NaF) is an anticoagulant which is often used for examination material sampling of blood glucose level, because NaF is considered to be capable in obstructing the glycolysis process. The examination of blood glucose level is generally using serum samples because it is done simultaneously with other test, so that more practical and efficient. The research goal is to know the comparison of blood sugar level of serum, NaF plasma, and K2EDTA plasma sample. The research type is analytic with cross sectional. The research result of serum blood sugar level average was 174 mg / dl, NaF blood sugar level average was 177.15 mg / dl, EDTA plasma blood sugar level average was 74.10 mg / dl. The statistic test result with Kruskal Wallis was obtained p> 0,05 that means there was no significant difference on blood sugar level of serum, NaF plasma, EDTA plasma. This is because the timing checking is done right after the sample taking (about 10 – 15 minute) so this process of glicolysis which influence the blood sugar level.

Keywords: blood sugar level, serum, plasma, EDTA, NaF


Spontaneous psoas hematoma in patients receiving anticoagulation therapy is a rare condition, but sometimes very serious even fatal, if not properly treated on time. One of our patients developed large spontaneous psoas hematoma while intensive rehabilitation therapy due to recent stroke with global aphasia and right hemiplegia. He had undergone anticoagulation therapy with warfarin and prothrombin time was within therapeutic range. Patient revealed sudden cold sweating with change of vital sign. Because of global aphasia, he could not explain subjective symptoms, but revealed rebound tenderness in right lower quadrant on physical examination. Emergency abdominal & pelvic CT scan showed large hematoma on right iliopsoas area with retroperitoneal extension. Because of unstable hemodynamics and high risks for surgery, transcatheter arterial emboilzation was recommended. Bleeding was controlled successfully after transcatheter arterial embolization, and vital sign was stabilized without other neurologic change.


The common approach to implement DDC (Digital Down Conversion) on FPGA is based on a look-up table, which requires a huge volume of ROM to achieve high resolution. This paper porposes a pipelined architecture for implementation of DDC on FPGA, which, based on CORDIC algorithm, can save considerable hardware resources and improve the speed performance as well. Finally, a quantization error analysis and simulation results are presented.


The purpose of this paper is to research how to identify and restructure the binary data fragments which were stored on device efficiently and accurately. Take widely used AVI video file format for example, we proposed a method to identify fragments and carve them into files based on structural features, after the studying of carving technical principle of video and AVI file structure. At last, make a simulation to test the method. The results show that it can recover AVI video files from storage devices without Meta system information and achieved very high percentage of accuracy. Introduction With the development of information technology, equipment for road monitoring or vehicle video forensics is widely used. As an important source of evidence, monitor video plays an important role in order management and traffic accident handling. Usually, the data of monitor video is huge, and it is often stored in sequential or non-sequential form in storage devices. Because of limited storage space, repeated erasures are needed during use, which will make the data severely fragmented and caused a great obstacle to forensic. The traditional recovery method relies on system meta-information. It is difficult to recover when the meta-information is incomplete, even if the data is not covered. Data carving technology overcomes the shortcomings of traditional data recovery techniques. It attempts to recover and reconstruct files from an unstructured raw disk image binary data stream, without relying on the file system of the source disk image, carving the "shape" of certain documents from a digital "plane" under the conditions of automatic or minimal manual intervention [1]. This article focuses on AVI format video files that are widely used in surveillance video and driving recorders. It focuses on how to efficiently and accurately identify and extract target fragments in seemingly indistinguishable binary fragmented data, and reorder and reconstruct the fragment files. As an important part of computer forensic analysis, its tools or methods has continuously improved, and theoretical research is constantly deepening and improving[2]. Video files are complex and have a large amount of data. In the early days, There is less research on video files, Most of the research focus on case analysis which taken by specific video tools. The data carving methods are not universal, such as WS. Van Dongen [3] recovers the video which recorded by Samsung Video Recorder; Huang Bugen [4] recovers the MP4 video in the SANYO camera. In recent years, in order to cope with the various types of document processing and complex fragments carving requirements, many researchers have introduced related field theories from different perspectives. For example, foreign researchers have introduced graph theory and greedy algorithms into document carving, which brought many new carving theory and methods, enriched carving theory. Andrew B. Lewis [5] researched the compressed data and proposed a method of carving MPEG video. In 2013, Huang Wei [1] used a combination of keyword and binary gap carving to complete the carving; in 2014, Gi-Hyun Na [6] proposed a frame-based MPEG video carving method, carving MPEG video successfully. In 2015, Liu Liying [7] proposed an AVI data extraction method based on the internal features of AVI files and an AVI fragment reorganization method based on the frame length information in each frame and file index. Li Zichuan [8] proposed a debris-level search technique for video file data by recording time in WFS non-universal file system. Xia Rong et 3rd International Conference on Automation, Mechanical Control and Computational Engineering (AMCCE 2018) Copyright © 2018, the Authors. Published by Atlantis Press. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/). Advances in Engineering Research, volume 166


Formally verifying system properties is one of the most effective ways of improving system quality, but its high manual effort requirements often render it prohibitively expensive. Tools that automate formal verification by learning from proof corpora to synthesize proofs have just begun to show their promise. These tools are effective because of the richness of the data the proof corpora contain. This richness comes from the stylistic conventions followed by communities of proof developers, together with the powerful logical systems beneath proof assistants. However, this richness remains underexploited, with most work thus far focusing on architecture rather than on how to make the most of the proof data. This article systematically explores how to most effectively exploit one aspect of that proof data: identifiers. We develop the Passport approach, a method for enriching the predictive Coq model used by an existing proof-synthesis tool with three new encoding mechanisms for identifiers: category vocabulary indexing, subword sequence modeling, and path elaboration. We evaluate our approach's enrichment effect on three existing base tools: ASTactic, Tac, and Tok. In head-to-head comparisons, Passport automatically proves 29% more theorems than the best-performing of these base tools. Combining the three tools enhanced by the Passport approach automatically proves 38% more theorems than combining the three base tools. Finally, together, these base tools and their enhanced versions prove 45% more theorems than the combined base tools. Overall, our findings suggest that modeling identifiers can play a significant role in improving proof synthesis, leading to higher-quality software.


Fractures of the distal femur in patients who have had a total knee arthroplasty are uncommon (0.3% to 2.5%),7,21,41,49,50 and fractures of the proximal tibia even rarer (0.39% to 0.5%).3,5,6,1B,23,27,39,40,45,51 Orthopedic surgeons, however, are likely to encounter these fractures with increasing frequency because of the increasing numbers of arthroplasties performed in elderly patients. The vast majority of periprosthetic fractures occur as the result of trauma, which may be trivial. There are many predisposing factors for these fractures, including osteopenia, neurologic disorders, medications, rheumatoid arthritis, previous arthroplasty, and infection (Table 1). These same factors also increase the likelihood of fracture comminution, and the presence of poor bone quality makes fixation difficult and prone to failure. To complicate matters further, this patient population often cannot tolerate immobilization of a lower extremity without losing the ability to ambulate because of systemic illness, neurologic compromise, or multiple joint involvement. All clinicians would agree with the principle of early and definitive fracture management and the avoidance of prolonged bed rest and inactivity, especially in the elderly. The best option for the treatment of these challenging fractures is controversial, however, with both operative and nonoperative methods being adv~cated.~,~,~~ ,~~,~~,~~ To facilitate appropriate management, studies have proposed classifications and treatment algorithms for both femoral and tibia1 periprosthetic fracture^.'^,'^,^^,^^,^^ Regardless of the treatment selected, dealing with comminuted and deficient bone is a major challenge. It can be managed by the use of autogenous bone graft, polymethylmethacrylate with or without metal reinforcement, augmented modular components or custom implants, cortical or cancellous allograft, or allograft-prosthesis composites. Each of these methods has inherent advantages and disadvantages.


Departures from complete frequency redistribution (CRD) in hydrogen lines are investigated for solar prominences. Partial redistribution effects (PRD) are found both in the wings (their already known lowering) and in the central part of the L alpha line; a new feature is evidenced here: the partially coherent scattering in the near wings of the line leads to a double-peaked profile mirroring the incident solar radiation. With a low density model, we obtain a good agreement with OSO 8 observed profiles. On the contrary, the PRD computed L beta profile (lower density, no reversal) departs from the observed one, a result which calls for more progress in terms of non-LTE transfer and modelling.


This article employs population survey data for Trinidad and Tobago to investigate the likelihood of being married, both legal and common law in the present or the past, as compared to being never married, in a developing economy. The article finds support for the sex-specialized theory of marital formation, with men valued more and women valued less for their economic contributions to the family. Socioeconomic status and ethnicity play an important role in marital formation with sex specialization less likely to occur among Africans than the more advantaged ethnic groups. One of the consistent findings is that family structure matters crucially in predicting both legal and common law marriages. For example, living in a large, multigenerational household tends to impact the likelihood of marriage, as compared to remaining single, in opposite ways for men and women, with men in large households more likely to be married but women less likely to be married.


The chemical, petrol, tinctoral or pharmaceutical industries are responsible for phenols run-off in environment. The presence of phenols in some ecosystems is also related to the production and degradation of numerous pesticides and the generation of industrial and municipal sewages. Some phenols are also formed during natural processes like the formation of phenol and p-cresol during decomposition of organic matter or synthesis of chlorinated phenols by fungi and plants. Phenols are harmful ecotoxins. The power of the toxic influence of the compounds depends on the position of the substituents. For instance, a chlorine atom substituted in ortho position in phenol molecule decreases its toxicity and meta substitution increases toxic action of the compound. Phenols reveal peroxidative capacity, they are hematotoxic and hepatotoxic, generate mutagenesis and carcinogenesis toward humans and other living organisms. Methylphenols commonly exist in the environment, often in considerable concentrations The highest concentrations of methyl-phenols are noted in waters situated near plants that produce coal tar (creosote)– reports that concentration of 4-methylphenol in ground water exceeded 2 mg/L [1]. Some national protection agency [23] has regulated concentration of phenol in wastewater below 4 mg/L in order to protect human health from the potential toxic effects caused by exposure to phenol. In general, removal of phenol from wastewater is quite desirable. However, phenol is not easy to remove from its dissolved state in water due to its considerable molecular polarity which brings about its high solubility over 10 wt%. Therefore, efficient methods for removing phenol from its aqueous solution have been desired from the viewpoint of environmental protection. Until now, many approaches have been explored for treating phenol in wastewater. Green microalgae, Ankistrodesmus braunii and Scenedesmus quadricauda, were used o degraded phenols [2], or extracts from artichoke (Cynara scolymus L.) flower bracts The extracts contained various isoenzymes of both peroxidase and polyphenol oxidase [3]. Also biocapsules with immobilized enzyme using a layer-by-layer configuration and their application for removal of phenol and bisphenol A [4] and two phenol degrading strains, Pseudomonas sp. PCT01 and PTS02, were investigated


Full-scale ground tests of an externally blown flap system were made using the wing of an F-111B airplane and a CF700 engine. Pressure and temperature distributions were determined on the undersurface of the wing, vane, and flap for two engine exhaust nozzles (conical and daisy) at several engine power levels and engine/wing positions. The test were made with no airflow over the wing. The wing sweep angle was fixed at e6 deg; and the angle of incidence between the engine and the wing was fixed at 3 deg; and the flap was in the retracted, deflected 35 deg, and deflected 60 deg positions. The pressure load obtained by integrating the local pressures on the undersurface of the flap, F sub p was approximately three times greater at the 60 deg flap position than at the 35 deg flap position. At the 60 deg flap position, F sub p was between 40 percent and 55 percent of the engine thrust over the measured range of thrust. More than 90 percent of F sub p was contained within plus or minus 20 percent of the flap span centered around the engine exhaust centerline with both nozzle configurations. Maximum temperatures recorded on the flaps were 218 C (424 F) and 180 C (356 F) for the conical and daisy nozzles, repectively,


Abstract: Perilymphatic atrophy can be a complication of intralesional corticosteroid injections given for the treatment of conditions such as psoriasis, alopecia areata, and keloids, and intraarticular corticosteroid injections given in diseases such as rheumatoid arthritis. It may become manifest as perilesional linear, depigmented, atrophic streaks, which are usually most prominent in patients with dark‐colored skin.


The present research work is based on a communicational analysis about HIV/ADIS through informative campaigns, directed to youngsters from 16 to 21 years old from the neighborhood San Francisco in the Parish Pascuales in Guayaquil, Province of Guayas in 2017. In the first chapter, which is the problem, we could observe communicational campaigns about the illness that have been done before. In the theoretical frame is divided into many exes, which were chosen in order to deepen the information the topic, information and prevention of the disease. Regarding methodology, it will be descriptive and inductive; therefore, it is necessary to point out the main characteristics which will take throughout the investigation. Finally, the results of the universe will be analyzed regarding the proposal; we will keep the communicational prevention campaign against HIV/AIDS for youngsters from 16 to 21 years old.


The wireless sensor nodes utilizes the wireless channels in the frequency bands of the 802.11, 802.16, 802.15.4, 802.15.1 and other similar wireless standards. The wireless sensor networks are built of the small sensor nodes built upon the microcontroller platforms such as PIC, 8051, ARM, AVR, etc. During the periods when the WSN nodes are in working condition, they need secure cryptographic keys for secure propagation of the sensitive information. Efficient key management and distribution scheme play an important role for the data security in WSNs. Existing cryptographic key management and distribution technique usually consume higher amount of energy and put larger computational overheads on Wireless sensor nodes. The cryptographic keys are used on different communication levels of WSN communications i.e. neighbour nodes, cluster heads and base stations. A successful corporate key administration and distribution policy is required to keep up the security of the remote sensor systems. The problems described in the base papers are related to the requirement of energy efficient key exchange policies for WSNs. So to overcome the above problem there is a need to design the model to solve the key-problem of energy efficient and secure key exchange scheme. The proposed model has been found improved after the in-depth result analysis over the given scenario.


GPRS, EDGE, 3G and HSDPA are wireless data services that are deployed by Mobile operators to provide higher data rate. This paper provides a set of measurements that are used to evaluate, from user perspective, these types of data services in the State of Kuwait. The Measurements are taken in different areas of Kuwait. Measurements show that HSDPA is the best wireless data connection offered by the mobile operators in the state of Kuwait. The measurements are based on measuring the Quality of Service (QoS) experienced by one mobile user running applications such as FTP and WWW on laptops connected to GPRS, EDGE, 3G, HSDPA networks.


Quadrotor UAVs have been widely used in many fields due to their merits of flexible maneuverability, vertical take-off as well as landing, and hovering. To achieve successful engineering applications, effective motion control of quadrotor UAVs should be guaranteed. This paper conducts a comparative study of motion controller designs for the quadrotor UAV. First, the commonly used attitude representation methods are compared and analyzed, and the dynamic model expression of the quadrotor UAV is established. Then, three typical motion controllers are introduced, which are the PID controller, integral backstepping controller, and fuzzy robust controller. Finally, based on the QDrone as well as the related experimental platform, the performance of these three controllers is tested. Some discussions are carried out based on the experiential results, which excepts to provide some guidance to the flight control system design for quadrotor UAVs.


WEB BIS is more and more popular,but the independent development and running of it is quite a heavy burden for medium and small businesses.It is workable and economic to carry out concrete application development on the open platform of Google Maps.This article discusses the development of WEB BIS through DOM-defining GMAP based on Google Map API.


The aim of this study was to analyze the specificity and dynamics of psychomotor development in children from triplet pregnancy. The studied group was composed of siblings from triple pregnancy (T1, T2, T3), including two girls and one boy. This longitudinal study comprised three stages: stage I – children aged 25 months, stage II – children aged 29 months, and stage III – children aged 38 months. At each stage, the psychomotor development of children was examined with the Third Edition of Bayley Scales of Infant and Toddler Development (BSID-III) and subjectively by their mother. Additionally, medical and nursing documentation was analyzed. Łucja Bieleninik 1 · A,B,C,D,E,F,G Mariola Bidzan 2 · A,B,C,D,E,F,G Aneta Koszewska 3 · B,D,E


The base-assisted cyclometalation of 2-phenylpyridine (2-phpyH) by Cp*Co(III) was holistically addressed both theoretically and experimentally. Combined DFT and DLPNO-CCSD(T) methods assisted by QT...


Contrasting Survival Strategies of Hatchery and Wild Red Drum: Implications for Stock Enhancement. (May 2008) Jessica Louise Beck, B.S., Indiana University of Pennsylvania; M.S., Florida Institute of Technology Chair of Advisory Committee: Dr. Jay R. Rooker Post-release survival of hatchery fishes is imperative to the success of any supplemental stocking program. The purpose of this research was to identify differences between hatchery and wild red drum (Sciaenops ocellatus) and determine if pre-release exposure techniques improve survival of hatchery individuals. Objectives were to contrast survival skills of hatchery and wild red drum from different locations, and examine if exposure to natural stimuli (e.g., habitat, predators, live prey) enhances survival skills in naïve hatchery red drum. Laboratory trials using high-speed videography (250 frames per second, fps) and field mesocosm experiments were used to investigate differences in prey-capture (e.g., attack distance, mean attack velocity, capture time, maximum gape, time to maximum gape, gape cycle duration, and foraging behaviors) and anti-predator performance (e.g., reaction distance, response distance, maximum velocity, time to maximum velocity, mean acceleration, and maximum acceleration) of hatchery and wild red drum. Results indicated that anti-predator performance measures differed significantly between hatchery and wild red drum. Variability in prey-capture and anti-predator performance for hatchery and wild red drum was high (CV range: 5.6 – 76.5%), and was greatest for hatchery fish for the majority of performance variables tested. Exposure to habitat (Spartina alterniflora marsh) did not appear to afford any obvious survival benefits to hatchery red drum, although survival skills did vary according to ontogenetic stage. Hatchery red drum exposed to natural predators (pinfish, Lagodon rhomboides) exhibited significantly greater attack distances during feeding events, and anti-predator


Using 2-hydrazinopyridine, dimethyl butynedioate and sodium methoxide as raw materials, a new pyridine-pyrazolone derivative containing multiple nitrogen coordination atoms was synthesized through a multi-step reaction, namely the ligand 1-(2-pyridine)-5-hydroxyl -1H-pyrazole-3-carboxylic acid methyl ester (HL). Using solvothermal method, two novel transition metals Co and Zn complexes of pyrazolone were synthesized. The structures were characterized by infrared spectroscopy, XRD and X-ray single crystal diffraction. Notably, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay showed that 2 displayed relatively high cytotoxic activity against Hep-G2 and MGC80-3 cancer cells.


Zero-shot Learning (ZSL) aims to transfer knowledge from seen image categories to unseen ones by leveraging semantic information. It is generally assumed that the seen and unseen objects share a common semantic space. Most of existing ZSL methods focus on how to connect the visual space and the semantic space. However, since there are some visual distribution differences between seen and unseen objects, the projection function learned by those seen classes is biased when transferring knowledge to unseen classes. We argue that, although the unseen objects are class-agnostic, the visual distribution information of unseen samples can be generated by exploiting semantic features. In this paper, we propose a Compound Projection Learning (CPL) model to transfer knowledge from seen to unseen objects by exploiting the information of both seen and class-agnostic samples. With the projected semantic representation by CPL, effective constraints such as projection loss and semantic reconstruction loss can be explored for seen and unseen objects, respectively, such that the semantic ambiguity across seen and unseen objects is reduced. Additionally, we utilize a similarity network to further explore the inter-class relationship by employing the labels and the similarities between seen and unseen classes. Extensive experiments on ZSL benchmark datasets show the effectiveness of our proposed approach.


To study the alternation and the clinical significance of detection of plasma neuropeptide Y in patients with liver cirrhosis. Of the Patients with liver cirrosis (n=64), males 40, females 20, aged 45±23 years, 57 had hepatitis B cirrhosis, 4 alcoholic cirrhosis, 2 hepatits C cirrhosis, 1 cardiovascular cirrhosis, with GI tract bleeding 20, ascites 36, hepatic encephacopathy 12 and hepatorenal syndrome 4. According to child's classification 28 cases were in group A, 23 in group B and 13 in group C. The levels of plasma neuropeptide Y in fasting state were measured by using RIA, and 40 healthy people (n=40; 26 males, 14 femals, aged 42±20 years) were tested as controls. Plasma concentrations of neuropeptide Y in group A (121.6±28.9 pg/ml) was lower than that in healthy controls (142.3±40.5 pg/ml)(P0.05), and group B (63.4±24.8 pg/l), group C (45.6±21.7 pg/ml) were singnificantly lower than that in healthy controls and group A (P0.01). The levels of plasma neuropeptide Y was significantly lower in patients with liver cirrhosis, and was aggravated with the degree of injury of the liver function. It suggested that NPY may take part in the pathogenesis of the liver injury and was related with the classification of liver function.


The post-collisional Variscan evolution in Sardinia (Italy)—Corsica is characterized by Late Carboniferous—Permian extensional tectonics that affected the whole belt and was due to gravitational collapse of the previously thickened crust. Evidence of this late Hercynian extensional tectonism is widespread throughout the basement and its development is chronologically constrained by radiometric, sedimentary and paleontological data. Extensional tectonism in Sardinia may be related to a composite shear framework characterized by two events: an Early Shear Event (ESE) and a Late Shear Event (LSE). The ESE is characterized by shear zones in amphibolite facies conditions with a top-to S/SE shearing in relation to a dome structure. The LSE consists of strike slip ductile shear zones (mainly dextral shear zones) associated with retrograde metamorphism, commonly coeval with syntectonic plutons. The ESE accommodated the exhumation of the Variscan belt in Sardinia, while the LSE belongs to the Late Variscan strike-slip faulting common in SW Europe. The Late Variscan geodynamic evolution of the Maures Massif (south-eastern France) is characterized by extensional tectonism related to noncoaxial deformation in HT to LT metamorphic conditions: the close relationships between these two areas suggests that they belong to the same segment of the Variscan belt.


(Please turn to page 18) Florence Wagman Roisman (email@example.com), a former PRRAC Board member, is the William F. Harvey Professor of Law and a Chancellor's Professor at Indiana University Robert H. McKinney School of Law in Indianapolis. She also is a member of the Board of Directors of the Inclusive Communities Project. This essay expresses her personal views. We may hope that the Supreme Court's opinion in TDHCA v. ICP will lead these agencies affirmatively to obey the command of the Fair Housing Act before that statute marks its 50th anniversary. Courts and commentators will have much more to say about the significance of the U.S. Supreme Court's June 25, 2015 decision in Texas Department of Housing and Community Affairs v. Inclusive Communities Project (TDHCA v. ICP). I believe it makes three enormously important contributions to the law and policy governing housing discrimination and segregation. The three contributions regard residential racial segregation, disparate impact, and the Low Income Housing Tax Credit program. Although the case went to the Supreme Court as a challenge to disparate impact as a basis for liability and usually is discussed in that context, I think the ruling's implications for residential racial segregation are even more important, so I discuss those first.