Enzymes provide the critical means by which almost all biological reactions are catalyzed in a controlled manner. Methods to harness and exploit their properties are of strong current interest to the growing field of biotechnology. In view of many unique physical and optical characteristics that are advantageous for studying enzyme activity at quantum dot (QD)–bioconjugate interfaces, we endeavored to explore the possible influence on conformation and catalytic functionality of alkaline phosphatase (ALP), a clinical marker enzyme, by conducting in vitro enzymatic activity assay and using molecular spectroscopic techniques such as UV-visible absorption, fluorescence, circular dichroism (CD) and Fourier transform infrared (FTIR) spectroscopy. The resulting experimental data were then analyzed in the context of the classical Michaelis–Menten model. The results show almost 60% and 30% decrease in enzyme activity on interaction with 10 nM Cys-CdTe or Cys-CdS QDs, respectively, suggesting inhibition dependence on particle nature. CD spectra measurements indicated that QDs induced a decrease of α-helical content and an increase of β-sheet structure in ALP, resulting in the loosening and unfolding of the protein skeleton. Interestingly, when QDs and substrate were added simultaneously to enzyme molecules, catalytic inhibition was significantly reduced indicating protection of enzyme structure by substrate molecules. Further, we demonstrate that protein-encapsulated QDs do not affect the catalytic functionality of enzyme molecules. The present study provides valuable information which may have significant ramifications in various biomedical applications, such as biosensing, drug delivery, cellular imaging, etc.


Many worldwide countries are cooperated to cope with unprecedented global warming. Korea also have planned to control greenhouse gas emission to get over global warming. One of the most important issues is how the responsibilities for greenhouse gas emission are allocated. This study deals with the problem of greenhouse gas allocation decision among industries which requires an optimal trade-off among environmental effectiveness, cost efficiency, and equitable burden sharing. We formulated the problem as goal programming considering the industry characteristics of Korea major industries. To do this, a supply chain network is constructed using the input-output analysis involved in the network. Then, we suggest some scenarios to show how the optimal allocation works.


【Task】 The invention relates, comprises a centrifuge having a peripheral band orifice drilled across a plurality of annular zones superposed with each other (ZA), it is assumed that the centrifuge is in centrifugation position, It relates to a device for internal centrifugation of mineral fibers. The apparatus further comprises at least two annular zones (ZA1, ZA2), the number of orifices per unit surface area (NS1, NS2) is less than 5%, in particular 10%, by even less than 20% different.


The acceptance by the early women converts of Islam and of Muḥammad as the Apostle of the new monotheistic religion is expressed usually by a stereotyped phrase, which takes the form of "so-and-so became resigned to God and made a bond with the Apostle of God". At a later date a convert was merely required to repeat the shahādah, but Wensinck has shown that probably this creed was only evolved after Muḥammad's death. In the very early days the mere fact that a woman attended the prayer meetings held by Muḥammad was no doubt sufficient for her to be considered as a member of his community. This being so, what then was the significance of the bond made between the women converts and Muḥammad ? It was possibly made in order to give a more formal aspect to their conversion and to make solemn confession of their belief in one God and their allegiance to Muḥammad as his Apostle, as also to include their acceptance of his ordinances.


Vertical distribution of sediment carbon and nitrogen was studied for the three saline-fresh Cyperus malaccensis wetlands( Tajiaozhou,Bianfuzhou,Shanyutan) in Min River estuary. Results indicated that the concentration of organic carbon( OC) was in the range from 12. 98 to 31. 32 g ·kg- 1,while the concentration of organic nitrogen( ON) was from 1. 37 to 2. 46 mg·kg- 1. The content of NH+4- N,NO-2- N and NO-3- N were from 1. 36 to 11. 69,0. 05 to 0. 34 and 0. 20 to 5. 72mg·kg- 1,respectively. Distribution pattern of OC and ON among the different saline-fresh wetalnds were Tajiaozhou Shanyutan Bianfuzhou and Shanyutan Bianfuzhou Tajiaozhou respectively. Total inorganic nitrogen( TIN) concentrations in Shanyutan were obviously higher than those of Bianfuzhou and Tajiaozhou. The sediment C/N ratio had significant negative correlations( P 0. 01) with the sediment pH,conductivity,and moisture content. C/N ratio was influenced by conductivity mainly through ON variation,while OC was more sensitive to the moisture. Meanwhile,the sediment NH+4- N and NO-2- N contents were positively related( P 0. 01) to the sediment' s pH,conductivity,and moisture. A remarkable positive correlation( P 0. 05) between conductivity and ON was also found.There were no significant correlations between OC,ON,TIN and sediment mean grain diameter.


A little more than a decade ago, MIT initiated a program of Freshman Advisor Seminars (FAS) in response to the need for improved academic advising and intellectual diversity in the freshman year. FAS build on a "very small group" learning model by bringing eight advisees together with an advisor (normally a faculty member) and an upperclass associate advisor for a weekly, informal seminar on one of a wide variety of leader‐chosen topics. FAS have become the dominant mode of first year advising at MIT, with approximately 90% of the freshman class enrolled in 135 different seminars during the 1996‐97 Academic Year. This paper introduces the MIT FAS program, sets forth its origins and its goals, and presents a case study of its implementation within one MIT academic department. Some lessons learned are extracted from the study.


To build a harmonious society is a new task proposed by the Communist Party of China.To fulfill the task,the most important work is in the countryside,as,without a harmonious rural society,a harmonious China would remain a dream forever.Therefore,more efforts must be taken to develop agriculture and rural economy,to raise the quality of rural residents,to enhance democratic politics in the countryside,and to safeguard social stability in the rural areas.


Inherent possibilities of digital processing of broadband signals and images envisaging further development are considered. The greatest problems in this regard arise when we attempt to perform such integrated transformations as Fourier convolution and transformation, requiring a great many of operations of multiplication and addition. While amplification of velocity of switching of the basic elements has a theoretical limit, the degree of paralleling of multiprocessor systems is limited by the complexity of control devices. One of the ways of essential amplification of the processing systems' speed consists in execution of integrated transformations via specialized analog processors, which become a constituent of the common multiprocessor system. The role of such analog devices can be taken by echo-processors, among which the photon echo-processor (PEP) exceeds its analogs by many basic parameters. The latter has an important advantage, i.e. an ability to process both one-dimensional signals, and fields and images within one step of its work.


In the analysis of new changes of contemporary capitalism,we must adhere to the basic basic viewpoints on the development of capitalist society,recognize that there is still more room for the development of capitalist productive forces,there is still a large room for self-regulation of relations of production.We should actively absorb the outstanding achievements of civilization building a socialist capitalist society,meanwhile,we also have to recognize and overcome historical limitations on the capitalist theory,innovate and develop Marxism in practice.


The article presents the results of the study of law and medical students' attitudes towards legalization of eu-thanasia in Moscow. Focussing on students is due to the fact that they are the youngest progressive stratum of society, representatives of the new generation. Faculty selection is dictated by the hypothesis that the context of educational programs and practices imprints on attitudes towards the problem of euthanasia. The study of law and medical students' opinions helps to comprehend how the young generation and future specialists treat the problem, how they assess the legal and moral aspects of euthanasia legalization and what arguments they give supporting their point of view. Therefore, the results of the study can be beneficial for public dialog on this topic. The aim of the study implied identifying the factors that determine their opinion, considering the dual ar-gumentation about euthanasia in the Russian Federation based on the results of the study.


In this study we investigate the climatological features of North Atlantic polar lows by two different cyclone tracking methods. The first method by Zahn et al. (2008) is based on the digital bandpass filtered MSLP-fields in the spatial range 200∼600km and is especially designed for polar lows. The second method is of Hodges (1995) also uses a bandpass filter in the same spatial range but based on the discrete cosine transforms (DCT) and applied to MSLP and vorticity fields. The latter was originally designed for cyclones in general and has been adapted to polar lows for this study. Both algorithms are applied to the same RCM output fields gained from dynamical downscaling the NCEP/NCAR reanalysis data. Temporal and spatial distribution of North Atlantic polar lows by these two methods are compared based on statistics of tracks, life time and intensity. Reasons of differences are discussed. Dynamical links between these features of polar lows and large scale pressure patterns will also be studied.


The aim of this study is to evaluate the financial analysts' earnings forecast bias and accuracy. We focus on annual earnings per share forecasts issued on Italian listed firms by brokerage analysts and find that (1) analyst are on average optimistic about the future prospects of covered firms; (2) median optimistic bias as well as forecast dispersion decline during the forecasting period toward the actual realization; (3) earnings forecasts are on average inaccurate; (4) accuracy increases with the firm size, actual profit realization, brokerage size, analyst's specific experience on firm and, in general, during bull markets, while it declines with the number of firm the analysts follows and when the time from the forecast date to the release of actual earnings increases; (5) forecasts are less accurate for technological listed firms, compared to firms in other sectors.


Wereduce the problem of the orientation of mitosis to that of theorientation of the mitotic spindle by taking advantage of the classicobservationthatinanimalcells theplaneofcytokinesis is perpendiculartothelongaxisofthespindle(Morgan, 1927;Wilson, 1928;Kawamura,1977; Rappaport and Rappaport, 1985; Rappaport, 1985; Mabuchi,1986; Bjerknes, 1986). Thus our problem is to determine the relativeplacementofthepolesofthemitoticspindlein three-dimensionalspace.Our solution is


This paper is a critique of pornography from within the framework of Heideggerian phenomenology. I contend that pornography is a pernicious form of technological discourse in which women are reduced to spectral and anonymous figures fulfilling a universal role, namely that of sexual subordination. Further, the danger of pornography is covered over in the public sphere as a result of the pervasive appeal to its status as mere fantasy. I argue that relegating the problem to the domain of fantasy is superficial and specious at best, inasmuch as fantasy itself is ultimately grounded in everyday reality. When not concealed as innocu- ous "fantasy," pornography has been defended under the rubric of "free speech." One of my aims is to repudiate this approach by revealing it as grounded in a highly suspect and self-contradictory phallocentric view of language. Rae Langton's (2009) recently published collection of essays on pornography attacks the problem largely in terms of "objectification" and the Austinian notion of "illocutionary disablement" from a position of authority. In this paper, I too confront the issues of language, objectification, and authority, but as articulated by means of Heidegger's critique of technology.


The easiest way to explain what "people-first" language is might be to examine what it is not. We can do this by considering commonly accepted uses of titles that we may hear every day-usages such as "Coach Pat" or "Doctor Bob."


In this work, we will introduce two methods to find the solutions of nonlinear differential equations with proportional delay. The first method is the differential transformation method (DTM) and the second method is the Elzaki transform (ET). Moreover, we will make use of a combination of these two methods. Consequently, the results tell us that this technique can be an alternative way of solving the linear and nonlinear differential equations with proportional delay.


Wittgenstein's views invite a modest, functionalist account of mental states and regularities, or more specifically a causal/computational, representational theory of the mind (CRTT). It is only by understanding Wittgenstein's remarks in the context ofa theory like CRTT that his insights have any real force; and it is only by recognizing those insights that CRTT can begin to account for sensations and our thoughts about them. For instance, Wittgenstein's (in)famous remark that "an inner process stands in need of outward criteria" (PI:Β580), so implausible read behaviorally, is entirely plausible if the "outward" is allowed to include computational facts about our brains. But what is especially penetrating about Wittgenstein's discussion is his unique diagnosis of our puzzlement in this area, in particular, his suggestion that it is due to our captivation by "pictures" whose application to reality is left crucially under-specified. it is only by understanding. What sustains the naive picture is not a captivation by language, but, at least in part, our largely involuntary reactions to things that look and act like our conspecifics. We project a property into them correlative to that reaction in ourselves, and are, indeed, unwilling to project it into things that do not induce that reaction.


We consider a generalized four-parameter q-algebra AA† − qγA†A = qαN+β, [N, A] = −A, [N, A†] = A†, associating with operators A and A† the nonlinear f-oscillator operators, defined in terms of the usual harmonic oscillator operators as A ≡ af(N) and A† ≡ f*(N)a† (where a and a† are operators of the Weyl–Heisenberg algebra and N = a†a). The function f(N) is determined from the commutation relations. We write the Hamiltonian for the free f-oscillator and obtain its energy spectrum. Besides, expressing the Hamiltonian in terms of coordinate and momentum, we determine the potential and inertia functions (coordinate-dependent mass) and analyse their behaviour by varying the parameters.


This exploratory study describes comparisons of high-school and college men and women regarding attitudes toward the "importance" of humor in their lives. 45 high-school students and 33 college students volunteered to complete Vitulli's Humor Rating Scale. This Likert-type scale has 12 items dealing with varying opinions regarding the importance of humor for men and women. Four subscales measured general humor appreciation, male-oriented humor, female-oriented humor, and differentiation of humor by sex, respectively. Results from a 2 × 2 × 4 factorial (mixed) design yielded a significant difference between high-school and college groups. Scheffé tests of multiple comparisons gave significant differences between high-school males and college males regarding male-oriented humor and between high-school males and high-school females regarding male-oriented humor. There were no significant differences between college males and college females regarding male- or female-oriented humor. These data are explained in terms of "androgynous" social conditioning.


This paper presents Differential Evolution (DE) based approach for the allocation & coordinated operation of multiple FACTS (Flexible AC Transmission System) devices for the improvement of power transfer capacity in an interconnected power system. The DE based approach is applied on IEEE 30-bus system. The system is reactively loaded starting from base to 200 % of base load. FACTS devices are installed in the different locations of the power system and system performance is noticed with and without FACTS devices. First, the locations, where the FACTS devices to be placed is determined by calculating active and reactive power flows in the lines. A Differential Evolution based algorithm is then applied to find the amount of magnitudes of the FACTS devices. A comparative analysis with PSO (Particle Swarm Optimization) is also done. This approach of Differential Evolution based placement of FACTS devices is tremendous beneficial both in terms of performance and economy is clearly observed from the result obtained.


The largest group of coordinate transformations leaving invariant the Schroedinger equation of the n-dimensional harmonic oscillator is determined and shown to be isomorphic to the corresponding group of the free-particle equation. It can be described as a Galilei group in which the time translations have been replaced by the group SL(2,R) of projective transformations. The relation between the oscillator group and the spectrumgenenating algebra of the harmonic oscillator is investigated. The relevance of the oscillator group and the group SL(2,R) for general quantum systems is discussed. (auth)


The developing course of self-developed fixed-mercury catalysts from laboratory research to commercial application was reviewed.The widespread commercial use of fixed-mercury catalysts were prospected.


Columnar defects, through 2.2 GeV Au-ions irradiation, were introduced into Bi/sub 2/Sr/sub 2/CaCu/sub 2/O/sub 8+/spl delta// (Bi-2212) bicrystals with [001] twist grain boundaries. Studies of the effect of heavy ion irradiation on the transport properties of the bicrystals were performed by measuring the irreversibility line and critical current within the constituent single crystals and across the [001] twist grain boundaries before and after irradiation. We found that the columnar defects greatly increased the irreversible temperature determined both within the single crystals and across the grain boundaries. However, the enhancement on critical current by the columnar defects measured across the grain boundaries is not significant, while more than an order of magnitude increase in the single crystal critical current was observed.


State-of-the-Art Very Large Precision Masks (VLPMs) manufacture is presented in this paper, including the inspection and repair of these Cr/glass VLPMs. The plates were manufactured by using custom designed and constructed Large Area Stepper and Large Area Inspection and Repair System. VLPMs with stepping precision of 0.25 micrometers and critical dimension as small as 2 micrometers in an effective area of 508 mm X 508 mm have been produced using the Large Area Stepper. The Inspection and Repair system measures CDs and defect density. The custom designed software allows the operator to mark the defect type and its position, therefore the Inspection and Repair system is able to automatically repair dark defects by evaporating the chrome with a YAG laser, and clear defects by using laser enhanced metal deposition. Using these custom systems, defect free VLPMs were manufactured. VLPMs are used in the production of Flat Panel Displays, circuit boards or any other large effective area lithographic application. Flat panel display production costs are reduced by substituting stepping lithography by contact or projection lithography using VLPMs.


This study investigated the effect of using the iPad on children's achievement of Layla kindergarten in Saudi Arabia, in Aflaj district, compared to the traditional method. The study sample was formed of (42) male and female children during the second semester of the scholastic year 2013/2014. The sample population were randomly selected using the simple sample selection and then distributed into two groups: the control group (22children) were taught using the traditional method, and the experimental group (20children) were taught using the iPad. An achievement multiple choice test was given to the population of the two study groups, and the test credibility and reliability were confirmed (reliability coefficient was 0.85). The study results showed the existence of differences with statistical indication (α = 0.05) between the achievement of the experimental group children and those of the control group. The implications of the results are that the iPad can benefit children in improving their language skills in a motivating learning environment. The results were in favor of the experimental group children, which were attributed to iPad teaching method. They showed that there were no statistically differences attributed to the gender variable or to the interaction between the gender variable and teaching method variable. The study was concluded by giving some recommendations and suggestions pertaining to this study.


Today's generation of fathers is more involved in the daily care and upbringing of their children than has been the case in the past. This is particularly true in Scandinavia, where progressive family policies encourage fathers to spend time with their infants. As fathers' participation in early child care continues to increase, the need to understand more about fathers' parenting behaviors and early father-child interaction also grows. The overall aim of this thesis was to expand the current literature on early father-child relationships by investigating questions related to fathers' parenting behaviors with one-year-olds in the cultural context of Norway. To accomplish this, data from the Behavior Outlook Norwegian Developmental Study (BONDS), a longitudinal study tracking 1159 children's social development from six months, were utilized. In Paper I, the aim was to investigate family concordance and gender differences in early parent-child interaction. Both fathers and mothers from 39 families were observed on separate occasions with their one-year-old children; 20 girls and 19 boys. Parents' and children's behaviors were recorded from video-taped observations of structured interactions by means of micro-social coding methodology. The results showed no within-family concordance between mothers' and fathers' behaviors with their child, whereas children's negative engagement with each parent was moderately correlated. Gender differences found in parent-child interaction at one year were few but noteworthy. For parents with boys, fathers were overall more positively engaged than mothers. Moreover, fathers of boys displayed higher levels of positive engagement than those of girls, whereas mothers of girls and boys displayed similar levels of positive engagement. In contrast to previous findings, mothers did not verbalize more than fathers. Girls were overall more positively engaged during interaction with both mothers and fathers as compared to boys.


Cirrhosis due to hepatitis C (HCV) infection, with or without hepatocellular carcinoma (HCC), is the leading indication for liver transplantation (LT) worldwide. Recurrent HCV infection of the allograft is universal if the virus is detectable at the time of transplant, with variable clinical course. In one third of liver recipients recurrent HCV infection lead to cirrhosis in the graft within only 5 years after LT. A small proportion of recipients can develop cholestatic HCV (CHC), a severe form of recurrence carrying a poor prognosis. In the last years, the approval of interferon-free (IFN-free) regimens for the treatment of chronic HCV has been a major step forward in Transplant Hepatology. The safety and efficacy of direct acting antivirals (DAAs) allow to treat patients awaiting LT as well as individuals with HCV recurrence after LT. Here we present two studies including HCV-infected patients in the peri-transplant setting. In the first study we aimed to assess the persistence of HCV-RNA in liver explants of HCV-infected patients treated with an IFN-free regimen on the waitlist for LT, and to analyze if its presence was associated with relapse after LT. Moreover, we investigated the potential role of the innate immune response on the persistence of HCV-RNA in the liver. Residual HCV-RNA was detected in liver explant in 67% of HCV-infected patients treated with DAAs on the waitlist, and with serum HCV-RNA negative at transplant. Nevertheless, HCV-RNA persistence in liver explant does not seem to be associated with virological relapse after transplantation, except in cases where liver HCV-RNA concentrations are high. Interestingly, we also found that the intrahepatic IFN pathway is down-regulated in patients treated with DAAs.
In the second study we investigated virological mechanisms involved in the pathogenesis of cholestatic HCV (CHC) after LT, assessing the HCV quasispecies evolution and presence of specific mutations within the NS5B region, before and after LT, using ultra-deep pyrosequencing. Patients included in this study were at the extreme spectrum of hepatitis C recurrence: mild disease with an excellent long-term outcome and patients with CHC with a poor outcome. We showed that in patients with CHC, the predominant virus strain outgrow the others and generates a relatively uniform quasispecies. In these patients, HCV appears to acquire an increased fitness in the new graft, since we found that the master sequence present before LT propagated in most of CHC patients after LT, but not in patients with mild HCV recurrence. We cannot exclude that specific mutations within HCV genome of patients with CHC may explain the high viral replication capacity and fitness. Indeed, we found specific mutations in the HCV genome of some patients with CHC, but our sample was not sized to show significant differences with individuals with mild hepatitis C recurrence. A further step forward could be to introduce these mutations in in vitro models to test their impact on virus replication/fitness.
In conclusion, the antiviral treatment of hepatitis C infection with DAAs before liver transplantation seems the ideal option in the liver transplant setting. However, in patients treated with DAAs on the waiting list, who have high explant HCV-RNA concentrations and a downregulation of IFN-pathway, another therapeutic strategy should be choose in order to avoid HCV recurrence after LT.
In patients who develop a cholestatic hepatitis C recurrence after LT, the application of specific mutations of HCV polymerase gene in in vitro models might be crucial for a better understanding of the mechanisms underlying this severe form of HCV recurrence.


The "Circumvesuviana" railroad in Naples, Italy, has created an interchange station between its own network and that of the State railways, in order to facilitate change of trains on the part of users and assist mobility over a metropolitan span of about 80 kms. In the article, a description is given of the various phases of construction of the work, which was carried out in normal and pre-stressed concrete structures astride a double railway transit, constituted by two old stone tunnels, without interrupting operation. The station has been equipped with the latest installations for the safety of railway operation and for the movement and information of users.


The article deals with an evolution of viewpoints on interaction between metaphor and personifications. Personification is considered as a special case of metaphor. Personification examples of advertising touristic discourse of Germany are analyzed, a concept of toponymical personification is described.


Letter from Albert Sydney Burleson to Dr. Joseph Pound detailing instructions on how to apply and be provided an increase in pensions from $12 to $16 as per his service in the Mexican American War. There is an enclosed document that shows the actual act of Congress that was passed to gain this increase; in part the act reads: "any person who served ninety days or more...during the late civil war or sixty days in the war with Mexico...be entitled to receive a pension as follows..." There is a three-tiered pension setup, those who are sixty two years or older gets $12, seventy years get $16, and seventy five or older get $20.


This paper reports the synthesis of new norbornene and exo‐N‐hydroxy‐7‐oxabicyclo[2.2.1]hept‐5‐ene‐2,3‐dicarboximide derivatives and their binding to the 5‐HT1A, 5‐HT2A, and 5‐HT2C receptors, in order to identify selective ligands for these 5‐hydroxytryptamine (5‐HT, serotonine) receptor subtypes. The combination of structural elements (heterocyclic nucleus, hydroxyalkyl chain, and 4‐substituted piperazine) known to be critical for affinity to 5‐HT1A receptors and the proper selection of substituents led to compounds with high specificity and affinity toward serotoninergic receptors. The most active compounds were selected and further evaluated for their binding affinities to D1, D2 dopaminergic and α1, α2 adrenergic receptors. 4‐[3‐[4‐(2‐Furoyl)piperazin‐1‐yl]propoxy‐2‐ol]‐4‐aza‐tricyclo[5.2.1.02,6]dec‐8‐ene‐3,5‐dione 3e with Ki = 5.04 ± 0.227 nM was the most active and selective derivative for the 5‐HT2C receptor with respect to other serotonin receptors, and the most selective derivative versus dopaminergic and adrenergic receptors.


Using slow rate ADC can realize data acquisition to wide frequency analogy signal by using equivalent-time sampling technology,which reduces not only the difficulty of realization,but also the cost of the system.The paper mainly states the theory and method of high-speed data acquisition system based on equivalent time sampling.The logic control unit of the system are integrated in CPLD.The integrated density of the circuit is improved greatly.


ABSTRACTThis reply piece is a response to the article by Michel Bauwens and Jose Ramos, "Re-imagining the Left through an ecology of the commons: Toward a post-capitalist commons transition". In it...


This paper discussesd the work of early intervention for hearing-impaired children in Zhejiangprovince. The authors introduced the components of the project, including system setup, network connection, testingprocedures and information exchanges.


We study manufacturing firms' asymmetric inventory investment in response to sales changes. Focusing on the costs of resource adjustment and stockout which likely differ in sales-increasing and sales-decreasing periods, we predict and find that inventory investment declines less during periods with sales decreases than it rises during periods with sales increases. We validate this claim by showing that managers' expectations of future demand and desire to avoid inventory stockouts are important determinants of this asymmetry. In addition, we find that asymmetric inventory investment provides useful information for predicting future sales growth, and that both managers' and analysts' sales forecasts are positively associated with the asymmetry. Lastly, we document that forecasts of future sales growth that incorporate asymmetric inventory investment are associated with lower absolute forecast errors than benchmark forecasts. Overall, we highlight the importance of inventory information in understanding managers' resource adjustment and utilization decisions that have implications for forecasting future demand. Our findings on asymmetric inventory management provide new insights to fundamental analysis based on inventory signals.


The influence of the weather on human movement behaviour is of interest in urban planning and transportation research. Traditionally, this is investigated with travel surveys and questionnaires. In this paper we propose to use a combination of Context-Aware Movement Analysis (CAMA) and Multichannel Sequence Analysis (MSA) on real meteorological data and GPS tracking data. CAMA integrates movement data with spatio-temporally simultaneous meteorological information. MSA represents a person's movement as a multichannel sequence of states, where each channel describes either travel mode or the meteorological conditions. Similar movement patterns can then be identified by aligning sequences and finding their differences.


Independent innovation is the joint aim of enterprises and Universities.The paper,from the concept of "independent innovation",gives the details of the advantages and disadvantages in making the independent innovation both in enterprises and universities.Then the paper shows the ways how to make innovations by the enhancement of research and development in pillar industries,the construction of platforms for scientific and technological innovation and service,and the construction of strategic alliances in enterprises,universities, and research institutes,the combined application for major projects by universities and enterprises,the participation in the construction of professional towns,and the protection of intellectual property rights ect.with emphasis on the practices in enterprises,universities,and research institutes in South China University of Technology.And furthermore,the paper predicts the ways to make the innovative university and country.


In nearly neutral media, the reaction of allylic tributyltin with aldehydes is effectively catalyzed by Bu2SnCl2 complexes. The addition of coordinative reagents and benzoyl chloride as a quencher is required of the catalytic allylation, furnishing homoallyl benzoates in good to excellent yields, where a regioreversed coupling to conventional methods using crotyltributyltin is exclusively observed.


The study on "Women's issue" in A Dream of Red Mansions has becoming the focus of"Hong studies".Since Comparative Literature developed into the showing studies,Chinese culture is forced to compare with western culture.Therefore,the myth of sex equality in the studies on "A Dream of Red Mansions" came into being.This paper queries the "sex equality" by study the existence condition of the girls in Daguan Garden,the culture role of Jia Baoyu and the self-atonement of Cao Xueqin.


Despite its clinical importance in the treatment of a number of neuropsychiatric disorders, such as Parkinson's disease and schizophrenia, there are few compounds, either agonists or antagonists that are highly selective for the D2 dopamine receptor (D2R). Most compounds with activity at the D2R also exhibit significant affinity for the D3 or D4 dopamine receptors (D3R or D4R), or other G protein‐coupled receptors (GPCRs). Development of D2R‐selective ligands has proven especially problematic due to the high structural similarities of the orthosteric binding sites of the D2‐like receptors (D2R, D3R and D4R). Importantly, highly selective D2R antagonists could represent improved therapeutics for treating the positive symptoms of schizophrenia with potentially fewer side effects due to off‐target activities. Thus, in order to identify selective antagonists of the D2R, we implemented a high‐throughput screening (HTS) campaign to interrogate over 400,000 unique compounds in the Molecular Libraries Screening Center Network library. Not surprisingly, most of the compounds that were identified as antagonists of the D2R were also antagonists of the closely related D3R. However, a small pool of antagonist compounds that exhibited significant D2R>D3R selectivity was identified. These compounds were characterized using orthogonal D2R and D3R functional assays (including several G protein‐mediated assays and b‐arrestin recruitment) as well as radioligand binding assays. One compound, MLS1946, was found to exhibit high affinity for the D2R (Ki ~100 nM) without measurable affinity for the D3R (Ki > 40 mM). This compound was further characterized using a number of D2R and D3R signaling assays and found to exert no activity an the D3R, while exhibiting potent antagonism of the D2R. Follow‐up studies were performed using an analog of the hit compound and a functional screen (b‐arrestin recruitment) of a panel of 168 different GPCRs. We found that the hit compound analog was completely devoid of agonist activity within this panel of GPCRs. In contrast, at the dose tested, the compound was found to completely antagonize dopamine stimulation of the D2R while exhibiting partial antagonism of the D4R. Surprisingly, the compound was devoid of significant antagonist activity at the remaining 166 GPCRs. These results suggest that the MLS1946 scaffold displays a highly selective D2R antagonist profile. We are currently engaged in a chemical optimization campaign to synthesize analogs around this scaffold to both interrogate structure‐activity relationships and optimize compounds for in vivo testing. It is anticipated that further development of the MLS1946 scaffold may lead to an optimized D2R‐selective antagonist with drug‐like properties for the treatment and understanding of dopamine‐related pathologies.


Two groups of Rhesus monkeys were previously established. One group included animals with immediate-type responses to respiratory challenge with ascaris antigen. The second group included animals with no respiratory reactivity to aerosol challenge with the same antigen. Both groups of Rhesus monkeys were subjected to controlled respiratory challenge with rabbit anti-human IgE. This anti-human IgE had sufficient cross reactivity with rhesus IgE to produce both the expected reverse passive cutaneous reactions and an acute respiratory response to aerosol challenge in five of six monkeys. The respiratory response to anti-IgE has been termed the reverse passive respiratory reaction. The characteristics of respiratory responses in animals reacting to anti-IgE were compared with those resulting from ascaris antigen challenge. The reverse passive respiratory reactions meet the criteria which have been established for the other acute previously described IgE mediated respiratory responses in Rhesus monkeys.


The invention discloses a load balancing processing method and equipment. The method comprises the following steps of acquiring operation time information of each task in one iteration period of one working node; according to the obtained operation time information of each task and an analysis strategy of a task to be migrated, determining a task to be migrated of the working node in the iteration period; when times of the task to be migrated exceed a setting value, migrating the task to be migrated to a working node whose task processing quantity is less than a setting threshold except for the working node. By using a task mode, a task migration in multiple iterative operations of working points is executed so that task load balancing between the working points is effectively realized; a problem that time consumption exists in a load balancing strategy in Giraph is avoided and simultaneously a problem that message communication network cost is increased in a speculative execution strategy in Hadoop is avoided; task migration efficiency in a BSP model is increased and a load balance property of the system is improved.


According to the actual situation of course management system,combined with the new demands for diversification of course management system,the intelligent learning assistant system is constructed based on context awareness technology.The basic function,system framework and realization of concrete key technologies of intelligent learning assistant system are discussed.The test shows that this system provides users with personalization,safe,easy-extension interactive services.


Biosensors designed on the principle of fluorescent resonance energy transfer (FRET) have been widely applied to visualize signaling cascades in live cells with high spatiotemporal resolution. In this paper, we review the work in our lab related to the application of FRET biosensors in studying molecular events in live cells, and our work using computational analysis methods to explore complex biological information implicated in FRET images. Membrane-tethered Src biosensors were used to visualize the dynamics of Src activity in subcellular microdomains. We have developed a finite element (FE) method to analyze the movement of biosensors. Based on fluorescence recovery after photobleaching (FRAP) experiments, the estimation and subtraction of biosensor diffusion revealed a high Src activity at cell periphery upon growth factor stimulation. In addition to Src, a RhoA biosensor was used to study the subcellular feature of RhoA activity in migrating HeLa cells. We have developed an image registration method to automatically track and quantify the FRET signals within user-defined subcellular regions, and classify the dynamics of subcellular pixels according FRET signals. The results revealed that the RhoA activity is polarized in the migratory cells, with the gradient of polarity oriented toward the opposite direction of cell migration. Therefore, FRET biosensors integrated with computational analysis provide powerful tools to precisely decode the complex dynamics of signaling transduction regulated in subcellular locations of live cells.


ObjectiveTo analyses the CT and MRI features of cerebral cavernous angioma(CCA) and evaluate the diagnostic characteristics of the images. Methods11 cases of pathologically proved CCA collected in the period of study in the Municipal Hospital. MRI examined 7 cases, MRI and CT 4 cases. ResultsThere are multiple lesions in 6 cases, in which 2 cases were supratentorial and 1 case infratentorial, 3 cases located widespread supra-and infra-tentorial. There were single lesion in 5 cases, in which 3 cases were supratentorial and 2 cases infratentorial. Nonenhanced CT scans demonstrate CCA as well-delineated focal oval or nodular-appearing lesions that demonstrate increased attenuation. CT scans demonstrate various degrees of calcifications in most CCA. The CCA demonstrate mixed signal intensities on both T1WI, T2WI and FLAIR images, with surrounding hypointense "hemosiderin rim" , and the hypointense rim is much wider on T2WI. Round-like hypointense hollow shadows with inequality of size are much characteristic on DWI. All lesions are without edema or mass effect on the surrounding brain parenchyma. Most cases (5/6) are none enhanced after contrast media injection, only 1 case enhanced markedly. ConclusionCT and MRI are helpful to discover CCA; MRI is superior to CT in diagnoses and characteristic. DWI has more sensibility to CCA.


Metamaterials are artificial materials designed to control and manipulate waves. They present the advantage to prohibit acoustic propagation in some frequency ranges called Band Gaps. In this paper, we present a series of Helmholtz-like resonators shaped for ultrasonic insulation purposes. This host plate is made of silicon in which the unit cell represents a phononic membrane formed by a sub-wavelength aperture and two Helmholtz resonators facing each other and immersed in water. The finite element simulations are performed between frequencies 1.7 MHz and 2.95 MHz. It is shown that such configuration exhibits a large band gap exceeding 1000 kHz and an attenuation up to -35 dB.


The transition between the anomalous diffusion previously reported in pulsed multipoles and classical diffusion has been observed at low poloidal magnetic fields, B≲100 G. The helium plasma parameters were ne =1010–1011 cm−3, Ti∼Te∼0.2 eV. The anomalous diffusion seen at higher magnetic fields scaled like vortex diffusion, but the transition point corresponds to a nonthermal vortex spectrum with effective temperature, T*∼106 eV. Transition from anomalous to classical regime is observed on a classical viscous damping time scale.


This research is a follow‐up to our earlier study in which we assessed the knowledge and conceptions of fundamental notions in chemistry of first year undergraduate students at the time of entry into university. It examines to what extent, after one year of study at university level, the conceptions of the students have evolved and how their knowledge of scientific theory has progressed. We have found that the conceptions of the students are often modified in the right way, but sometimes in the wrong way as well, and the results obtained seem to indicate that the ambitious aim of teaching (better acquisition of important notions by students) is far from being attained. The study also shows that for some notions the teaching of chemistry has too formal a character. To rectify this situation, we propose that practical work must include problems that are not only chemical in nature.


The fire tests of the normal concrete slab and polypropylene fiber reinforced concrete slab with different contents of polypropylene fiber are carried out through simulating the practical heating curve of material surface in the fire site. The results show that normal concrete has cracks due to the temperature gradient inside or outside the concrete during cooling after continuous heating, which is different from the spalling of high strength concrete at elevated temperatures,and the polypropylene fiber in the concrete can effectively restrain the crack development. The rebound hammer tests carried out on the post-fire concrete slabs shows that the spatial distribution of residual mechanical property inside the slabs correlates with the temperature field.


In the 1960s, the Windfall scandal led to the commissioning of the Kimber Report and ultimately to the systematic revamping of the securities regulatory system in Ontario (and in Canada). In this article, the author argues that the impact of the Bre-X scandal is likely to be modest by comparison. In light of Bre-X, this article addresses a number of questions about the regulation of small firms, primary market offerings, and the importance of appearances when deciding how to respond to such scandals.


This paper intends to construct a pricing model for power maket based on output decision.On the analysis of complete information static game,the model can induce different types of game which have different results for different market capacity.With the existence of price-difference contract we may control the contract amount of electricity to attain the purpose of control the game's result.Thus under certain conditions,there will be different results in the dynamic game from in the static game.


A partially persistent data structure is a data structure which preserves previous versions of itself when it is modified. General theoretical schemes are known (e.g. the fat node method) for making any data structure partially persistent. To our knowledge however no general implementation of these theoretical methods exists to date. This paper evaluates different methods to achieve this goal and presents the first working implementation of partial persistence in the object-oriented language Java. Our approach is transparent, i.e., it allows any existing data structures to become persistent without changing its implementation where all previous solutions require an extensive modification of the code by hand. This transparent property is important in view of the large number of algorithmic results that rely on persistence. Our implementation uses aspect-oriented programming, a modularization technique which allows us to instrument the existing code with the needed hooks for the persistence implementation. The implementation is then validated by running benchmarks to analyze both the cost of persistence and of the aspect oriented approach. We also illustrate its applicability by implementing a random binary search tree and making it persistent, and then using the resulting structure to implement a point location data structure in just a few lines.


In snowy country, a compaction process of snow has been demanded for performing efficient snow removal and disposal work. For achieving the work, a design of large pressure vessel is demanded in order to perform high speed compression of the snow and ice. This report aims to investigate the radial pressure generated during the high speed compression of ice pieces for obtaining a fundamental data to design a large pressure vessel. In the investigation, ice pieces were compressed by an axial formation pressure pz for pz = 0.0 to 5.0 MPa, and the radial pressure pr during the compression test was evaluated. It was found that the ice column having D = 80 mm diameter, H = 80 mm height and density of ρ = 0.84 g·cm-3 was obtained at pz = 5.0 MPa. And, the maximum radial pressure pr_max reached about 60 % of the axial formation pressure pz.


To meet the real-time requirements of major industry players and society, today, far and wide, there are video surveillance systems. With the recent development in technology and reduction in hardware costs, the number of cameras installed per kilometer is now increasing. The major challenge with video analytics is storage and response time. This chapter discusses transforming an IP camera into an Intelligent Camera by proposing a hybrid method of computational intelligence techniques like fuzzy, genetic, swarm optimization, reinforcement learning, ensemble methods, and deep belief networks to perform analysis at the place of data generation itself. With the acquired intelligence, a hybrid algorithm for anomaly detection and scene identification using fuzzy logic and deep learning can be designed. Deep learning models promise quick response time and better accuracy levels on image identification.


High temperature stress is a major limiting factor in the growth and development of tall fescue (Festuca arundinacea) in transitional and warm climatic regions. In this study, we evaluated the photosynthesis, PSⅡ functionality, and antioxidant activity of two tall fescue cultivars, Jaguar 3 brand (heat-tolerant) and TF 66 (heat-sensitive) in response to high temperature stress. High temperature stress caused a net photosynthetic rate reduction in the two plants due to stomatal and non-stomatal limitations, photoinhibition increase, and Rubisco activity reduction. High temperature stress modified PSⅡ functionality in leaves of the two plants, manifested by lower variable chlorophyll fluorescence yield (Fv), maximum photochemical efficiency of photosystem Ⅱ in dark adapted leaves (Fv/Fm), and efficiency of the open reaction centre in light (ΦPSⅡ(subscript open)) in the two heat shocked cultivars. Heat stress led to reductions in the chlorophyll a+b and chlorophyll/carotenoid ratios and to an increase in the chlorophyll a/b ratio for the two stressed cultivars. Moreover, high temperature stress significantly increased lipid peroxidation, decreased cell membrane thermostability, and changed the activities of ascorbate peroxidase (APX) and superoxide dismutase (SOD) in the leaves of both plants. All the above effects induced by high temperature were more expressed in the TF 66 than in Jaguar 3 brand. Our results contain some insights which may prove useful in the selection and breeding of heat-tolerant tall fescue turfgrass cultivars.


Medical education is failing to teach students about critical public health issues that will influence how they function as doctors, according to delegates at a meeting …


Interspecific hybridization was carried out between terrestrial orchid Cymbidium cyperifolim var.szechuanicum and epiphytic orchid C.floribundum.to study on the asymbiotic germination and rapid propagation of hybrid seeds.The results showed that Seven-month-embryo-aged-seeds had the highest germination rate,when treated with 0.1 mol/L KOH for 10 min.After germination,the best medium for PLBs propagation was Z4(KC+BA 0.4 mg/L + NAA 0.6 mg/L+KT 0.2 mg/L),the rate of PLBs proliferation could reach 12.8.Adding activated carbon to medium prevented the cut browning in the process of PLB's multiplication and differentiation.


The purpose of this study are: 1) To explain the presence or absence of policy influence of subsidized fertilizer, distribution channels fertilizer and income of farmers marketing of fertilizers to farmers' income and 2) Measure the level of influence the policy of subsidized fertilizer, distribution channels fertilizer and marketing performance fertilizers on the income of farmers, traders and fertilizer distributor. This research was conducted in February-March 2016 in the city of Padang. From the initial research and the description above, the authors conclude that the income of farmers is still low and less than optimal. The sample used in this study were 89 respondents using saturation sampling. The independent variables in this study is the policy of subsidized fertilizer, fertilizer distribution channels, and marketing performance fertilizer while the dependent variable is the income of farmers. This study is an explanation. Techniques of data collection is questionnaire. Technical analysis of the data using descriptive analysis and inferential analysis. To determine the effect of independent variables on the dependent variable partially, t test was used. Meanwhile, to determine the effect of independent variables on the dependent variable simultaneously, used F test assumptions used in the test of validity is if R-count> R-table item declared invalid. Based on test validity policy of subsidized fertilizer, fertilizer distribution channels, marketing performance and income of farmers fertilizers known to all items declared invalid meet the eligibility criteria are good and reliable instrument. The regression analysis of subsidized fertilizer policy values obtained t = 2.091 while t table = 1.988, and the significance value is 0,040 this value is smaller than α = 0.05 not significant effect on the income of farmers, Fertilizer Distribution Channels regression analysis obtained by value t = 1,762 while the value table = 1,988 so thitung


Rill erosion processes generate preferential flow paths that may increase the degree of connectivity of the soil surface and hence strongly modify its hydrological response. However, few studies have tried to quantify the effect of rill development on overland flow connectivity. For this purpose, changes in surface microtopography were monitored on three bare agricultural plots (3 m wide x 10 m long and 11% of slope) in Louvain-la-Neuve (Belgium) under natural rainfall conditions.


The SARS-CoV-2 virus that caused the 2019 new coronavirus infection (COVID-19) pandemic has posed an unprecedented challenge to the global health system and scientific community. As of this literature review, the infection has claimed more than 6 million lives, and more than 500 million people worldwide have already been infected with SARS-CoV-2. In addition to the basic, pulmonary manifestations of the disease, as well as the severe, life-threatening complications of acute COVID-19, the long-term changes that occur in the postcovid period also affect other systems: endocrine, cardiovascular, nervous, and musculoskeletal. In this literature review, using data from current scientific publications obtained by searching «covid-19 endocrine disorders», «postcovid endocrine disorders» and «postcovid syndrome endocrine disorders» in the MEDLINE (PubMed) database and «endocrine pathology and covid-19», «postcovid and endocrine pathology» and «postcovid syndrome and endocrine disorders» in the e-Library database, we focused on describing and discussing the complications and consequences that SARS-CoV-2 infection can have on the endocrine glands, including the adrenals, thyroid, pituitary, gonads and pancreas.


The evening papers are facing big difficult condition dues to internet's information influence,controlling of politics character and fading of culture role.These problems will be solved only when evening papers promote their power to transmit culture and value,become people's mouthpiece and help to create civil society.


This is a memoir about writing - about how deeply you can grow to detest it. From a purveyor of nonfiction, this might come as a surprise. It's the novelists and the poets with the inner lives and the psychic wounds, right? We're meant to pursue writing as an exercise of the rational intellect, except perhaps a permissible enthusiasm for our subjects. It's partly such assumptions that compel my describing the emotional trajectory I took in compiling my latest book, The Office...


In the early days of anaesthesia the anaesthetist observed the heart rate, the pattern of breathing and the patient's response to surgery. Later, the signs indicating depth of anaesthesia were recognized. The recording of arterial pressure during operation was introduced at the beginning of this century, but there were no further significant developments in monitoring until after the Second World War. The initial stimulus for the development of new techniques was the introduction of controlled ventilation for thoracic surgery. This was followed by the increasing use of methods of controlling the circulation (e.g. induced hypotension) and the development of cardiac surgery with its associated techniques of hypothermia and cardiopulmonary bypass.


An innovative new setting is to offer parents a place to work and their children a place for care at the same time, says Karen Faux.


Over these years,the prestressed concrete pile has been used in the project widely.This paper introduces a new type of fender pile.In this study,the cracks and deformation of prestressed concrete I-shape pile has been studied by the experimental,then the bearing capacity and the failure mode are analyzed.Through the experimental study,it is testified that the flexure bearing behavior of the pile satisfies for the requirement of the code and with the safety factor.


We tested the hypothesis that enrichment of the diet with docosahexaenoic acid (DHA) enriched egg yolk powder could modify specifically the (n-3) fatty acids content of rat plasma, red blood cells and heart membranes. Dose-dependent effect of DHA was studied in rats supplemented during 4 weeks. Three groups of adult male rats, DHA10, DHA35 and DHA60 (n = 5 each), had their diet supplemented with 10 mg, 35 mg or 60 mg DHA/kg body weight/day, respectively. Fatty acid composition of membranes and plasma lipids were determined. A significant dose-dependent increase in DHA was observed in all three types of samples. Arachidonic acid (AA) levels did not change in heart and red blood cell membranes whereas it increased significantly in plasma with the DHA35 diet. These results contrast with that previously reported for fish oil supplementation where a decrease in AA levels was reported. Hence, DHA enriched egg yolk supplementation leads to a specific accretion of DHA without competition on AA status.


Cuttings are a common soil and water bioengineering technique used for slope stabilization and erosion control along rivers. Above- and belowground growth of cuttings, especially immediately after installation, have a strong impact on the protective performance. To assess the effects of diameter on the early growth performance of purple willow (Salix purpurea L.), freshly harvested (nondormant) cuttings of different diameters (5 to 24 mm) were planted as part of an outdoor raised-bed experiment from March to October of 2010. The aim of this study was to investigate the growth performance of purple willow cuttings and to gain deeper insight into the plant's development during the first growth stage (six months). After two months of growth, 99% of the cuttings sprouted, and the diameter had no statistically significant impact on the sprouting performance of the cuttings. During the first four months, aboveground biomass production (Mag) was 5.7 and 4.4 (after two and four months, respectively) times higher than belowground biomass (Mbg). However, after six months, Mag and Mbg were balanced. The diameter of the cuttings had a significant impact on biomass development at all of the time steps. The cuttings of the diameter class C (15 to 19 mm) produced the most Mag and Mbg, with 33% and 34% of total Mag and Mbg of all diameter classes after six months. Four months after planting, at least 80%, and after six months at least 90%, of the Mbg was allocated in the lowermost third of the cuttings. The observations showed high Mag production for the entire period; Mbg production was relatively low during the first four months, which resulted in a diminished protective function of the roots until this specific point of development.


1 Department of Health Sciences. University Magna Graecia of Catanzaro, Italy; 2 Center for Clinical Research and Treatment of Eating Disorders, Azienda Ospedaliera Universitaria Mater Domini, Catanzaro, Italy; 3 "GNOSIS" Research and Psychotherapy Group V, Mondovì, Italy; 4 Department of Public Health, Experimental and Forensic Medicine University of Pavia, Italy; 5 Perelman School of Medicine, University of Pennsylvania, Center for Weight and Eating Disorders, Philadelphia, PA, USA JOURNAL OF PSYCHOPATHOLOGY 2017;23:137-144


The synthesis of milbemycin (1) is described. The key features of the synthesis include (1) an acetylide addition to trans-5,6-dimethylvalerolactone to set up a novel hydrolysis-spirocyclization, (2) a stereoselective conjugate addition to spiroenone 6, (3) a stereoselective Wittig reaction to establish the C(14)4(15) trisubstituted olefin, and (4) an enantioselective alkylation to establish symmetry at C(12). An intermediate previously prepared by Williams is intercepted to constitute a total synthesis.


Background: Enterococcus, which comprises of gram positive organism acts as opportunistic pathogens which has their natural habitat in genital tract, gut and oral cavity. Resistance to wide variety of antibiotics has made enterococcus one of the important cause for nosocomial infection. Emergence of aminoglycoside resistance has made it a feared pathogen. Objective: Objective was to isolate, speciate and determination of high level gentamycin resistance among Enterococcus species. Material and Methods: Clinical samples like pus, urine, blood, CSF etc. were collected and processed. Speciation was done through sugar fermentation test, followed by antibiotic sensitivity test. Results: Of the 81 isolates processed for species identification and antibiotic susceptibility testing, 38 were identified as E. faecalis, 27 as E. faecium, 15 E.avium and One E.durans. A total of 24 isolates showed resistance to high level gentamicin by disc diffusion method. Thus there were about 30[37.03%] Multi Drug Resistance [MDR] isolates among the 81 Enterococcus species. Conclusion: Increased incidence of High Level Aminoglycoside Resistance[HLAR]and MDR among the enterococcal species in the study, indicates indiscriminate use of broad spectrum antibiotics. Antibiotic stewardship, proper hygiene and rational use of antibiotics have to be implicated to prevent resistance among the enterococcus species.


Presented hematological indices for a stress-free selection of material from moose in the process of domestication depending on age and sex characteristics. Fluctuations in the blood parameters of moose have been established within various limits, taking into account the influence of various factors - the climatic, environmental, technological, physiological state of the animal, and age and sex characteristics. Considerable attention is paid to the selection of blood from moose, one of the most labor-intensive processes when working with them. Some tendency to fluctuations in hematological parameters in young moose has been recorded. This, possibly, is associated with a decrease in the action of colostral immunity, the formation of a specific defense of the body. Differences in blood indices in moose depending on gender were unreliable. However, in males, some of them - in terms of the content of erythrocytes, basophils, and monocytes - was higher than in females, and vice versa, in females - the number of leukocytes, lymphocytes, and eosinophils. It was shown that in young animals of 21-50 days of age, a neutrophilic profile prevails with increased content of segmented forms, and in adults - a lymphocytic profile. Compared with moose, which are in the process of domestication in animals living in natural conditions, expressed leukocytosis was recorded. As a result of the studies, the estimated norms of morphological parameters of the blood of moose in the process of domestication are established, depending on age and gender.


This paper demonstrates the modulating and demodulating fundamental theory of Trellis-Coded Modulation(TCM) as a combined coding and modulation technique.A four multidimensional 192QAM trellis coded modulation system is designed,and differential coding and bit conversion are combined to overcome the phase ambiguity problem for recovering carrier at the receiver.In addition,considering that the effects of fading can be substantially mitigated by the use of multiple-antenna diversity,it introduces a method for concatenating Space-Time Block Coding With Multidimensional Trellis-Coded Modulation.


This guide aims to provide resources supporting the Intro to Music Education class and assignments. Find resources for your professor's preferred citation style and learn about the tools available to help make citing sources faster.


With the release of Bluetooth Low Energy (BLE) version 5, the Bluetooth Special Interest Group introduced three additional physical (PHY) modes for BLE communication. These PHY modes enable an application to either double its throughput, or significantly improve its reliability, making BLE applicable to an even wider range of application domains. Unfortunately, no experimental study has yet investigated the actual performance of BLE 5's PHY modes in BLE connections or shown their trade-offs between energy efficiency, reliability, and throughput. Thus, how to use BLE 5's PHY modes to achieve specific application requirements is still an open question.
 To fill this gap, we experimentally study the performance of all four BLE 5 PHY modes in BLE connections and observe that it is, indeed, possible to double BLE's throughput or to increase BLE's reliability by using the new PHY modes. Furthermore, we provide guidelines using our measurements on how to select the most suitable PHY mode based on specific application requirements.


Here, the authors look critically at China's efforts to adapt its vast military/industrial complex to the service of its socialist market economy. The text offers discussion on political, macroeconomic, business and military perspectives of this complex issue.


In this paper,space vector pulse frequency modulation(SVPFM) algorithm is introduced into the AC induction motor inverter modeling and simulation.AC induction motor derived from this algorithm is a mathematical model.On this basis,a detailed simulation analysis of the motor speed,transient current and its spectrum is carried out.The results show that,for a simple signal or inverter with lower entry requirements,inverter model based on SVPFM algorithm is relatively simple and the carrier frequency is proportional to phase-frequency,which makes controllers have good performance and low prices.


The application of liquid chromatography/mass spectrometry (LC/MS) and LC/MS/MS with electrospray ionization to drug metabolism studies was investigated using S 9788 and various synthesized metabolic products as model compounds to assess the response characteristics with regard to compound lipophilicity and the influence of biological matrix components. The results obtained demonstrate the versatility of the electrospray ionization technique to analyse compounds of widely varying polarity and the power of MS/MS to identify unequivocally metabolic products. These techniques offer a very rapid screening procedure that can be used to identify metabolic products and thus provide important early metabolic information that can be used in the candidate drug selection programme. These procedures were then applied to an in vivo study sample and, using neutral loss MS/MS, it was possible to detect metabolites of S 9788 directly from a crude biological matrix (bile) without prior extraction or chromatography to confirm positively the identity of five important metabolites of S 9788 in the rat.


It is common to identify in educational articles or in the speeches of education professionals that it is important for the teacher to consider the previous knowledge that students bring from their reality and experiences to the classroom space. It is assumed that the current didactic models do not address educational needs and that continuing education programs represent a possibility for improvement when developing pedagogical strategies that can change the dynamics of the classroom. Thus, this study aims to identify the conceptions of students graduating from the postgraduate program in Physics teaching at the Technological University of Paraná (UTFPR-CM) on how to recognize the ways in which they deal with students' prior knowledge to the development of physical concepts. For the analysis and interpretation of the data, assumptions of the Discursive Textual Analysis will be used. The analyzed materials consisted of the educational products produced between 2014 and 2017 by the students of the Professional Master in Physics Teaching at the Federal Technological University of Paraná Campo Mourão Campus (Polo 32 of the MNPEF SBF) and of the documents made available by the Brazilian Physics Society that guide the National Professional Master's program in Physics Education. The results show that of the 18 (eighteen) defended educational products, 10 (ten) use the students' previous knowledge explicitly and 2 (two) do not use these terms in writing, however, implicitly they are developed in the proposed activities. There is also a concern with the use of theoretical frameworks that support the applied methodologies, in the diversity that the discipline allows. It is concluded that of the educational products analyzed, only a third of the teachers were concerned with developing a pedagogical proposal based on the students' previous knowledge.


Abstract : Seepage model studies were conducted for the proposed Oakley damsite using a three-dimensional electrical analogy seepage model. Test results indicated that uplift pressures beneath the spillway will vary from 59 percent of the net head at the upstream edge of the structure to 49 percent at the downstream edge. Test results also indicated that piezometric heads at the downstream toe of the dam even with a 1000-ft upstream impervious blanket will be higher than can be safely tolerated. Computed total seepage with the reservoir at flood control pool varied from 2780 gpm (6.2 cfs) to 3290 gpm (7.3 cfs). It is recommended that other seepage control measures such as relief wells and a positive cutoff be investigated.


The usage of second raw materials of the textile industry to produce silk decorative plaster is rather profitable and results in saving funds in construction and reducing cost of the principal product. The paper gives an example of the possibility of using second raw materials of the textile industry in the production of silk decorative plaster (liquid wallpaper) and considers technological solutions which enable reducing the cost of the finished product by 50 %.


This study analyzes the title of Taewang, which was used to refer to the kings of Goguryeo. Previous studies on the title of Taewang have used the limited historical materials available to focus on this issue from the standpoint of international relations or of the related institutional system. This paper, however, strives to analyze the title of Taewang from the standpoint of the changes that occurred in the perceptions of the royal lineage. Moreover an attempt is made to develop a wider understanding of the range of the title of Taewang through an interpretation of related historical materials. By carrying out the above-mentioned steps, the writer has been able to ascertain the following facts: The title of Taewang was used from the reign of Gogungnyangwang(故國壤王) until the end of the 6th century. The term Taewang is used to refer to a being much more superior than the 'king of kings' identified in previous studies. The background to the appearance of the term Taewang is consistent with the sixteen kingdoms period in which the local power clans, who all advocated the Cheon(天) belief, created the title of Tian-Wang(天王). Goguryeo kings, borrowing from the lore of Buyeo, established the concept of blood ties based on this notion of Cheon. In addition, the title of Taewang was used only for some time after the demise of Gogukwonwang(故國原王). This seems to indicate that the royal family of Goguryeo traces its origins back to Micheonwang(美川王). Thus, at this point, the notion of the Taewang lineage was formed as a means of differentiating this particular royal family from previous ones. The efforts to create a Taewang lineage led to the subsequent creation of a new method of composing epics, one that used letters. Goguryeo tried to promote the power of the nation and of the royal family by making their people read these epic poems.


Olmsted the man belongs to his own time, but his work and words continue to have meaning today... The editors are preserving a life and a work instructive for the future as well as of the past. -- Pennsylvania Magazine of History and Biography


An account having been desired of those two chief salt-springs in Germany, at Hall and Lunenburg, it was lately transmitted thus: The salt-springs at Hall in Saxony are four, called Gutiaar, the Dutch-spring, the Mettritz, and the Hackel-dorn; whereof the three first hold near the same proportion of salt; the last hold less, but yields the purest salt.


This article argues that although the act of mommy blogging may be empowering, the term itself reinforces women's hegemonic normative roles as nurturers, thrusting women who blog about their children into a form of digital domesticity in the blogosphere. Drawing on 29 blogs posts women wrote debating the term mommy blogger and 649 comments posted on these blogs, the author uses Judith Butler's concept of performativity to rhetorically analyze the term, using a techno-feminist lens and cyber-ethnographic approach. The author asserts that the use of the term mommy blogger continues the culturally ingrained performance of motherhood women learned since childhood, and, in so doing, holds women captive in this subjective norm that may not fit them. The use of mommy, versus mother, highlights the nurturing aspect of motherhood and conjures a prototype of the ideal mother, further marginalizing women by focusing on one attribute that does not apply to all women or even all mothers.


Writing "Guanzhen" as a self discipline,Liu Ji was an honest and incorruptible official who loved people and was intimate with people.He was also a man of reputation and integrity,outspoken and candid,never bowed down to power.Characterized by a fiery intolerance of evil and a vigorous audacity,he denounced the government's policy,took measures to punish the corrupt officials and enforced order and discipline.He was invested with a rank but declined it,making success insignificant and showing a paragon of virtue.Performing duties honestly and innocently,he changed the old backward habits and customs of burial with the simple one of himself.People have been praising highly of Liu BO-wen's morals of being government leaders from generation to generation.


The purpose of this paper analyzes the differences in sanctions regulation for violations of Article 15 and Article 19 of Law No. 24 of 2011 on Social Security Administering Body (Law 24/2011), which is a violation of Article 15 of Law 24/2011 subject to administrative sanctions (based on Article 5 PP 86/2013), while violations of Article 19 paragraph (1) and (2) of Law 24/2011 are subject to criminal sanctions (based on Article 55 of Law 24/2011). This study used normative juridical research methods. The results of this study show that there is a gap in the regulation and application of sanctions between Article 15 and Article 19 of Law 24/2011, whereas substantive violations of both articles are the same, because employers do not register themselves and their workers as participants to the Social Security Administering Body (BPJS). In fact, it aims to avoid the collection and payment of dues of participants who are responsible to BPJS. It should be a violation of Article 15 of Law 24/2011 not subject to administrative sanctions, but criminal sanctions article 55 of Law 24/2011 as well as Article 19 paragraph (1) and (2) Law 24/2011. The problem is constrained by the principle of legality in criminal law and depends on the 'Courage' of the judge to make a legal discovery. Conclusions obtained in the study are: (a) open possibility of application of criminal sanctions (ultimum remedium)against violations of Article 15 of Law 24/2011; (b) the occurrence of dissent against the possible application of criminal sanctions for violations of Article 15 of Law 24/2011 due to the separation of sanctions arrangements; (c) Employees of The Manpower Supervisory (PPK) must be observant and committed in law enforcement, especially against violations of Article 15 of Law 24/2011; and (d) on the issue of differences in sanctions it needs a deep understanding and built comprehensive legal construction as well as the need for legal discovery by judges.


This report documents the development and application of a grid generator, GRIDMAKER, for two- and/or three-dimensional domains. GRIDMAKER serves as a preprocessor for finite element models in solving two- and/or three-dimensional subsurface flow and pollutant transport problems. This grid generator is designed to generate three-point triangular or four-point quadrilateral elements for two-dimensional domains and eight-point hexahedron elements for three-dimensional domains. Based on the method of conformal mapping, the generation of interior nodal points within a two-dimensional domain of interest is performed numerically by the boundary integral element method (BIEM). For a three-dimensional domain, the BIEM techniques are applied in the projected horizontal plane, while the vertical coordinate is transformed by a normalized transformation using local layer thickness. Examples of grid generation for a two-dimensional domain and a three-dimensional three-layer domain are shown to demonstrate the capability of GRIDMAKER. A two-dimensional domain of an aquifer with a variable-depth layer is treated as a special case for depth-integrated two-dimensional, finite element subsurface flow models. The program has also been designed to accommodate the need for aquifers with heterogeneous systems by identifying the type of material in each element. 5 refs., 17 figs., 1 tab.


Refiners are facing a continuing need to add bottoms-processing capacity as a result of gradually deteriorating crude oil quality and flat-to-declining demand for residual fuel oil. Marketing high-sulfur coke will become increasingly difficult, requiring refiners to take proactive and innovative approaches. There is a perception, especially among US refiners, that world crude production has been steadily deteriorating and will continue to do so well into the future. (Poorer quality is defined as lower API gravity and higher sulfur content.) The need to continually add bottoms-processing capacity in world refining is, however, only partially caused by a trend toward poorer-quality crude. As will be shown, world crude quality, including sulfur content, has been relatively constant and is not expected to change appreciably in the future. On the other hand, the world product slate has been consistently shifting toward more light, low-sulfur products. This trend is expected to continue well into the future. The coincident decline in demand for residual fuel oil has been the prime driving force for additional bottoms processing. The paper discusses US trends, world trends, product demand outlook, petroleum coking, and economic relationships.


Teaching prayer is one of the great challenges facing the Jewish educator. Regular practice of prayer does not typify the Jewish community, and while each movement has a fairly clearly defined normative pattern of behavior, that norm is extremely far from the practice of the majority of those associating.


From the Publisher:
Which new Pokemon looks like an owl? Who is the Festival Maiden in the Pokemon 2000 movie? How much does Snorlax weigh? Put your Pokemon knowledge to the test with this 1,000-point quiz! It covers everything from the animated TV series to the movies, to the Game Boy games—including Gold and Silver. Grab a friend and see who has the brains, skill, and knowledge to beat the Ultimate Quiz and be a Pokemon Master!


Biomass and net primary productivity (NPP) are important factors for studying terrestrial carbon storage and the carbon cycle. Using data from existing literature, this study synthesized and analyzed a comprehensive database of direct field observations of forest biomass and NPP for Southwestern China. The biomass of mature natural forests and mature planted forests range from 81.2 Mg·ha−1 to 692.6 Mg·ha−1 (mean = 288.1 Mg·ha−1) and from 76.8 Mg·ha−1 to 670.1 Mg·ha−1 (mean = 181.5 Mg·ha−1), respectively. Mature natural forests have higher biomass than mature planted ones. The NPP values of natural and planted forests range from 1.4 Mg·ha−1·year−1 to 29.6 Mg·ha−1·year−1 (mean = 13.6 Mg·ha−1·year−1) and from 0.6 Mg·ha−1·year−1 to 26.5 Mg·ha−1·year−1 (mean = 9.9 Mg·ha−1·year−1), respectively. Correlations among biomass, NPP, and environmental factors show that NPP significantly decreases with latitude and increases with mean annual temperature, mean annual precipitation, growing degree-days on a 0 °C base, and mean annual drought index, whereas biomass positively correlates with stand age and leaf area index strongly. Karst forests exhibit almost the same NPP as non-karst forests, but the former have significantly lower biomass compared to the latter. Comprehensive regional data synthesis and analysis based on direct field observations of forest biomass and NPP are important for benchmarking global and regional vegetation and carbon models, estimating regional carbon content, restoring vegetation, and mitigating climate change.


This paper reviews the literature on composting process as it impacts the issue of greenhouse gases (GHGs) and global warming. A number of studies are examined which report the emissions of GHGs under differing composting scenarios. The major modeling attempts that could impinge on this issue including models of integrated waste management are discussed. Questions are raised concerning the need for additional research and the development of broadly agreed upon research methods and average values and conditions relative to GHGs and composting practices.


Metabolic networks formed by long sequences of biochemical reactions have been widely investigated to determine the catalytic role of genomes and how they interfere in the process. Many tumors have been reported to be the result of a pathology in the cell's pathway. Knowing that the complexity of the imbrication of such networks is beyond human reasoning, the use of artificial intelligence to help scientists in their experiments might seem adapted. This paper aims to present a logical model for metabolic pathways capable of describing both positive and negative reactions (activations and inhibitions) based on a fragment of first order logic. We also present an efficient automated deduction method allowing us to predict results by deduction and infer reactions and proteins states by abductive reasoning


The extensive use of social media has a tremendous impact on culture, business and politics in the world at large with potentially positive and negative effects. Personality traits are generally referred to as relatively stable patterns based on one's past experiences, upbringing, environment, all the opinions that one forms over time. It's closely bonded to how one feels, thinks and behaves, which has been associated with a wide range of important life outcomes and choices. Hence, in recent years, there has been a massive increase in the interest to develop models which use online data on human behaviour and preferences to automatically predict an individual's personality traits. In our research, to compute the accuracy of the personality predicted, it is first ensured that the dataset of stream of Tweets is almost equally divided into 16 different personality types, and be cleaned properly. We propose an advanced framework to identify and scrape tweets and retweets of Twitter user accounts and eventually applying Machine Learning algorithms for Personality Prediction.


In a hot climate, a large amount of solar heat irradiates on a roof, and it is transmitted to an occupied space beneath it through an attic. To interrupt this heat to attain a comfortable condition in the occupied space, ventilation of the attic is an important and effective measure. There are two ways of the ventilation, one is natural and the other is forces ventilation. The former measure should be considered prior to the latter from such reasons as simplicity in practice and power saving. Even though forced ventilation is applied, the natural air movement in the attic should be known to attain intended effect in forced ventilation. In this study, the air and heat movements by natural convection were searched for with two electrically heated plates in a laboratory. The heat flux on the surface, incline angle of the plates and aperture on the top joint ofthe plates were variables in the iments. The velocity and temperature measurement and flow pattern observation indicated that an aperture of an 50 mm or above this is required to evacuate the heat absorbed air and to cool the lower surface of a roof effectively.


Objective Developing better tools to screen obstructive sleep apnea (OSA) in professional drivers is fundamental in occupational health services, given the serious consequences this condition can have on their safety. Methods 1928 professional drivers were screened for OSA for three years using Berlin and Epworth questionnaires. 10.3% were suspected to be positive for OSA and send for polysomnography tests. We had a return of 39 data. We analysed the results with the MAP index because it has shown a high sensitivity and specificity in studies on professional drivers. The MAP index is easy to use and combines self-reported apnea symptoms (snoring and cessation of breathing) as well as objective data like age, sex, and body mass index (BMI). As the apnoea symptoms regarding snoring and observed apnoea are often not properly reported, we included the questions of the Berlin questionnaire about tiredness in order to improve the predictability and calculated a MAP2. To determine diagnostic test accuracy, we calculated both MAP indexes with apnea-hypopnea index (AHI) criteria already published in articles. Sensitivity, specificity, negative and positive predictive values (NPV, PPV) and area under curve (AUC) for receiver operating characteristic (ROC) were analysed. Predictive utility of both indexes was examined by characteristic variables, age ( Results Employing the MAP_index1 for OSA, the sensitivity obtained was 63.3% and specificity was 41.2%. The PPV was 58.3% and NPV was 46.7%. The AUC was 0.524 (95% CI 0.339–0.709). The accuracy was higher in younger versus older drivers (AUC 0.701 versus 0.620). Sensitivity for Map index2 was 59.1% and specificity was 52.9%. The PPV was 61.9% and the NPV was 50.0%. The AUC was 0.560 (95%CI 0.376–0.744). Conclusions The MAP 2 was had lower sensitivity but higher specificity. It cannot be considered as a better tool to predict obstructive sleep apnoea.


An anti-infectious hematopoietic neclosis viius (IHNV) nucleoprotein monoclonal antibody 1NDLV14D (IgG,), labeled with a streptavidin gold maiker was utilized to monitor infection of juvenile rainbow trout and coho salmon with lHNV at the ultrastructuial level Juvenile flsh were challenged with a v~rulent isolate of IHNV 01 mock-challenged with phosphate buffeied sallne In both juvenile rainbow trout and coho salmon. the target area for infection by lHNV appeared to be the esophageal/cardiac stomach region (ECSR) particularly the mucus-sec~et ing serous caidiac glands (MSSG) We pieviously found that at the light microscopic and ultrastructural levels in rainbow trout the MSSG form long cont~nuous glands in association with the esophageal mucosa located opposite the stv~rnbladder pneumatic duct In contrast, the coho salinon MSSG bud from the esophageal mucosa, forming dense bodies located posterior to the pneumatic duct With the aid of a 20 nm immunogold marker labeling the nucleoprotein of the virus, the piogression of the infection was followed from the esophageal mucosa to the MSSG in both species The ~mmunogold marker was located in both the rainbow and coho salmon ep~thelial cells which exhibited severe intercellular edema with sepalation of the mucosa at 24 h post challenge The immunogold marker was also found in the MSSG of both species with the ralnbow trout exhibiting glandular cystic degeneration as early as 1 h post challenge which further developed to a severe cystic degeneration by 24 h The coho salmon exhibited a similar but milder reactlon to the virus. h both species the 24 h post mock-challenged MSSG exhibited no morphological changes When the infechon was monitored in the MSSG of both rainbow trout and coho salmon at 1 and 24 h post viral challenge a statistically significant difference between the 2 time points was detected within each fish speaes , suggesting that replication occurred in the MSSG In addition a statistically significant difference was detected between fish species at both 1 and 24 h indicating quantitatively that the virus is replicated more efficiently in the MSSG of rainbow trout than in the MSSG of coho salmon


The present work involved the manufacturing and characterization of hybrid biocomposites from poly-lactic acid reinforced with cellulose derived fibers and synthetic high performing fibers, such as ...


This article constructs trigonometric polynomials of the sine and cosine whose sums are nonnegative. As an application, those nonnegative trigonometric sums are used to study the geometric properties of complex polynomials in the unit disk. The Strum sequences are used to prove the main outcome.


Summary In this third article of a series of papers listing first case reports of animal diseases published since 2000, the following seven cases of cattle diseases are discussed: - AL amyloidosis. - Canola oil intoxication. - Disseminated intracytoplasmic neuronal vacuolation. - Encephalomyelitis associated with Akabane virus infection in adult cows. - Lower limb deformity: "mirror image duplication of the plantar/palmar half of the distal portion of the digit". - Lupinus argenteus intoxication. - Novel Propionibacterium infection. After a short introduction, the bibliographical data, the abstract of the author(s), and some additional information derived from the article are given. The article will be regularly updated adding overlooked as well as new first reports.


The paper presents the results of tests of HPC (high performance composites) samples consisting of aramid and glass fabrics modified by agglomerates of WC and WO3 nanopowders. According to the test results, introduction of WC and WO3 powders into the composite plate structure makes it more rigid and elastic, increasing its ability to dissipate energy.


Background: Chitinase 3-like 1 (CHI3L1) is an important factor involved in the development of asthma. This meta-analysis assessed the association of the CHI3L1 polymorphisms rs4950928, rs10399931, rs883125, rs880633, and rs10399805 with asthma risk. Methods: The literature searches were conducted in PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure up until September 4, 2021, for relevant studies. Sixteen publications with 18 studies involving 5,005 asthma patients and 9,725 controls were included in this meta-analysis. Results: The meta-analyses showed that among East-Asian subjects, increased asthma risk was associated with CHI3L1 rs4950928 (GG + CG vs. CC: odds ratio [OR] = 1.43, 95% confidence interval [CI]: 1.09–1.88, p = 0.011; GG vs. CG + CC: OR = 1.64, 95% CI: 1.20–2.26, p = 0.002; GG vs. CC: OR = 1.97, 95% CI: 1.41–2.75, p = 0.000; and G vs. C: OR = 1.36, 95% CI: 1.12–1.66, p = 0.002) and rs883125 (G vs. C: OR = 1.42, 95% CI: 1.01–1.99, p = 0.043), whereas CHI3L1 rs10399931 was associated with reduced asthma risk (TT vs. CT + CC: OR = 0.79, 95% CI: 0.64–0.99, p = 0.038; TT vs. CC: OR = 0.77, 95% CI: 0.61–0.98, p = 0.030). In addition, we found an association between CHI3L1 rs4950928 and asthma risk in adult subjects but not children, while CHI3L1 rs883125 was associated with asthma risk in children. Conclusion: The CHI3L1 polymorphisms rs4950928, rs10399931, and rs883125 are important genetic factors for asthma among East-Asian subjects.


Based on a fully relaxed molecular-mechanics approach, we present a complete series of atomic force microscopy images of the NaCl(001) surface. For a given atomic structure of a diamond probe-tip [111] oriented, we analyze the results obtained from the two usual imaging modes either based on the monitoring of lateral or vertical forces. By accounting for the atomic relaxation of the whole system for any tip-sample configuration, we were able to get new insights about the achievement of atomic resolution on such substrates. Depending on the tip-sample distance range, the scanning of the NaCl(001) surface results in completely different behaviors associated with these two imaging modes. At very short distance we observed an increase of the apparent corrugation when working with the lateral force mode. The perturbations generated in the images by the presence of localized defects (vacancy and monoatomic step) are also analyzed within this model. These last calculations clearly indicate the fundamental role p...


By analyzing architecture of existing Heterogeneous wireless networks, mapping wireless resource management to wireless measurement indexing, proposed an improved model of CAN multidimensional ADHOC. Simulation result showing improvement in connectivity, network maintenance cost etc.


Isoflavones and soyasaponins are major specialized metabolites accumulated in soybean roots and secreted into the rhizosphere. Unlike the biosynthetic pathway, the transporters involved in metabolite secretion remain unknown. The developmental regulation of isoflavone and soyasaponin secretions has been recently reported, but the diurnal regulation of their biosynthesis and secretion still needs to be further studied. To address these challenges, we conducted transcriptome and metabolite analysis using hydroponically grown soybean plants at 6-hour intervals for 48 hours in a 12-h-light/12-h-dark condition. Isoflavone and soyasaponin biosynthetic genes showed opposite patterns in the root tissues; that is, the former genes are highly expressed in daytime, while the latter ones are strongly induced at nighttime. GmMYB176 encoding a transcription factor of isoflavone biosynthesis was upregulated from ZT0 (6:00 am) to ZT6 (12:00 am), followed by the induction of isoflavone biosynthetic genes at ZT6. The isoflavone aglycone content in the roots accordingly increased from ZT6 to ZT18 (0:00 am), accompanied by an increase in glucoside levels that peaked at ZT0. The isoflavone aglycone content in root exudates was kept consistent throughout the day, whereas that of glucosides increased at ZT6, which reflected the decreased expression of the gene encoding beta-glucosidase involved in the hydrolysis of apoplast-localized isoflavone conjugates. Co-expression analysis revealed that those isoflavone and soyasaponin biosynthetic genes formed separate clusters, which exhibited a correlation to ABC and MATE transporter genes. As summary, the results in this study indicated the diurnal regulation of isoflavone biosynthesis in soybean roots and the putative transporter genes responsible for isoflavone and soyasaponin transport.


An 11 year-old boy, who was riding his bike und wearing a safety helmet had been hit by a car in a head-on collision. The prehospital emergency health care included intubation and application of an unilateral thoracic drain. During the transportation into the next hospital cardiopulmonary resuscitation had to be implemented. Despite the recumbent thorax drain, the primary diagnostic revealed a persisting pneumothorax which made the immediate application of a larger sized thoracic drainage necessary. Following, circulation and vital signs improved. Blunt thoracic traumata most commonly represent a prehospital threat to the vital functions of accident caualties. Therefore it has to be claimed, that all physicians practicing as emergency doctors have to bei certain with the correct indication and application of thoracic drains also in children.