Abstract Adoptive cell therapy (ACT) with antigen‐specific T cells is a promising treatment approach for solid cancers. Interleukin‐2 (IL‐2) has been utilized in boosting the efficacy of ACT. However, the clinical applications of IL‐2 in combination with ACT is greatly limited by short exposure and high toxicities. Herein, a complex coacervate was designed to intratumorally deliver IL‐2 in a sustained manner and protect against proteolysis. The complex coacervate consisted of fucoidan, a specific IL‐2 binding glycosaminoglycan, and poly‐l‐lysine, a cationic counterpart (FPC2). IL‐2‐laden FPC2 exhibited a preferential bioactivity in ex vivo expansion of CD8+T cells over Treg cells. Additionally, FPC2 was embedded in pH modulating injectable gel (FPC2‐IG) to endure the acidic tumor microenvironment. A single intratumoral administration of FPC2‐IG‐IL‐2 increased expansion of tumor‐infiltrating cytotoxic lymphocytes and reduced frequencies of myeloid populations. Notably, the activation and persistency of tumor‐reactive T cells were observed only in the tumor site, not in the spleen, confirming a localized effect of FPC2‐IG‐IL‐2. The immune‐favorable tumor microenvironment induced by FPC2‐IG‐IL‐2 enabled adoptively transferred TCR‐engineered T cells to effectively eradicate tumors. FPC2‐IG delivery system is a promising strategy for T‐cell‐based immunotherapies.


Architecture. We implemented our model in PyTorch [2]. The local feature CNN uses a modified version of ResNet-50 as a backbone without pretraining. The sizes of the coarse-, middle-, and fine-level feature maps are 1/32, 1/16, and 1/4 of the original image size, respectively. The channel number of each layer's feature is converted to 256 by 1 × 1 convolutions. For the transformer, we use three layers for both encoder and decoder. Same with COTR, we disallow self-attention among the query points in the decode stage. For coarse-to-fine refinement modules, we set the crop window size w = 17, w = 13. For the AQC module, we set t = 1, Knum = 128. The distance threshold Th is set to 0.8 times of the corresponding side of patches during training and 0.6 times during inference.


One of the challenges of managing fast-track projects is the high level of uncertainty in both project definition and scheduling. Thus, communicating this project information among stakeholders becomes crucial for its success. One of the key stakeholders is the owner, who needs this information to guide its decision making process. When the owner has incomplete progress information, and the schedule constraints are poorly detected, communicated and managed, project delays are highly likely. In this research, 4D models and some concepts from the Last Planner System (LPSTM) such as lookahead planning and constraints analysis were used in order to propose a "BIM-Lean" planning approach. Thus, the identification and communication of project constraints is enabled within the project team, so they can be adequately managed. This research aimed at improving the stakeholders understanding of the project progress and planning reliability. The renovation of a shopping center, which remained operating during construction, was used as a case study. This case study allowed the project planning and progress control procedures to be assessed and the proposed planning approach to be tested. The final version of it was validated in a Charrette test conducted with both project professionals and civil engineering students. This Charrette measured the participants' understanding of the project progress and constraints management information with and without the proposed planning approach. The results showed that the planning approach improved the understanding on project progress and owner's constraints management, which was particularly valued by site professionals and owner representatives.


For cities in Minnesota, the classification as over or under 2,500 in population helps to determine the type of governmental accounting to which they must adhere. All cities over 2,500 in population must have a financial statement in compliance with generally accepted accounting principles (GAAP), which is a modified accrual basis of accounting. Modified accrual basis of accounting recognizes an economic transaction or event as revenues in the operating statement when the revenues are both measurable and available to liquidate liabilities of the current period. Available means collectible in the current period or soon enough thereafter to be used to pay liabilities of the current period. Similarly, expenditures are generally recognized when an event or transaction is expected to draw on current expendable resources. Cities under 2,500 in population may opt to use a cash basis of accounting. In 2008, 358 of the 637 small cities (56 percent) opted to use a cash basis of accounting. 3 Cash basis accounting provides for the recording of receipts (revenues) when received in cash and the recording of disbursements (expenditures) when paid in cash.


Empirical studies show that even the best performing option pricing models cannot sustain their performance for all contracts. It can also be added that each model can give the best price estimate for at least a set of contracts. Our aim is to detect which model (and parametrization) is the best price estimate for each individual contract and delta hedging. A model selection framework is proposed to achieve this aim. Both model selection and individual models are benchmarked with different error metrics and underlying assets. Results indicate that model selection is a good and consistent way of pricing option contracts.


Heat and power stations are often in need of optimizations. A simulation model is a tool for findingways to optimize the plant. The scope of this diploma work is to develop a simulation model ofBoi ...


The management of the physical documentation continues being a challenge of many centers, especially in those that, as the national libraries, should negotiate enormous collections and to adapt uses and guidelines of work to buildings with a high historic-artistic value. Is the case of the Biblioteca Valenciana, the national library of the Valencian Community, that since the year 2000 counts on own headquarters in the Monastery of San Miguel de los Reyes, jewel of the Spanish and Valencian renaissance. The study describes the system of robots installed in said year, its characteristics, utilities and advantages, as well as the problematic one detected after four years of operation.


Production scheduling of an open pit mine is a process of assigning mining blocks to different production periods so that the total profit from the mine can be maximized over the life of the mine. Long term mine plans are based on a single price value, but by the time development is put in place, production plan may have been proved wrong and production plan may not achieve the desired objective. So, the production plan is changed again which results in inefficient use of capital with low returns to investors. The proposed stochastic version of the conventional (deterministic) network flow algorithm is based on the use of multiple simulated realizations of metal selling price uncertainties. In comparison to the conventional pit optimization methods, where only one estimated or average type model of the deposit are used, the use of multiple scenario results in the ability to generate greater risk profiles in terms of metal price for pit design and production scheduling for greater profit making throughout the entire life of mine. The method is applied for optimizing the annual production scheduling at an Iron ore mine, and compared against a traditional scheduling method using the traditional single "average type" assessment of the mineral resources. In the case study presented here in, the schedule generated using the proposed SIP model resulted in approximately 5% higher NPV than the schedule derived from the traditional approach.


Based on the analysis of the functions of arable land and the expatiation with the forefathers' arable land value theory and arable land value composing theory,we put forward the social economic environmental value concept for arable land.In this opinion,there were the social security function,social stabilization function,ecological function and other function besides economic function of arable land.And the arable land value consists of five parts:quality value social security value,social stabilization value,ecological value and other value.


Given a topological ambient space $X$, We study properties of some popular topology on the Borel probability space $\mathcal{M}(X)$ in this paper. We show that the two types of vague topology are equivalent to each other in case the ambient space $X$ is LCH. The two types of setwise topology induced from two equivalent descriptions of setwise convergence of sequences of probability measures are also equivalent to each other for any ambient space $X$. We give explicit conditions for the two types of vague topology and the two types of setwise topology to be separable or metrizable on $\mathcal{M}(X)$. These conditions are either in terms of the cardinality of the elementary events in the Borel $\sigma$-algebra $\mathscr{B}$ or some direct topological assumptions on the ambient space $X$. We give the necessary and sufficient condition for families of probability measures to be setwisely relatively compact in case $X$ is a compact metric space. There are some extending questions on the topology of the Borel probability space $\mathcal{M}(X)$ at the end of the work.


Technology can be used to bring people closer together yet can also come between them and push them apart. In an age where discourse around our relationship with technology is becoming more widely discussed as problematic, what are the experiences of educators when they use technology for teaching? This chapter discusses influential conceptions of technology and maps them onto digitally mediated teaching. Tensions are identified within the relationships between educator, technology, and learner, and sociomaterial approaches are presented as a means to navigate these areas. Using a research project to demonstrate how sociomaterialism can work in practice, digital teaching was found to be re-distributed over space and time, resulting in consequences, not all of which were intended. This chapter proposes a more interconnected understanding of how people, technology, and learning are enmeshed and makes recommendations for further work that could be done in this area.


A compact conformal planar inverted-F antenna (PIFA) array, working at UHF band, is presented in this paper. This array consists of four PIFA elements. The parallel feeding network has been designed to drive the elements. The size of the proposed array is 100.5 mm × 48 mm. The proposed antenna is fabricated on a very thin substrate with a thickness of 0.254 mm, which is benefit for conformal structure. For the prototype, this array is assembled around a 16 mm diameter cylinder. The antenna has been successfully simulated, fabricated and measured, and the simulated and measured results show a good agreement with each other. The antenna has an omni-directional radiation pattern and a good gain in a very compact structure. The measured peak gain is -0.2 dBi at 432 MHz, and the bandwidth of the conformal antenna is 6 MHz.


Besides the pollinators (Agaonidae), several chalcidoid lineages of nonpollinating fig wasps are strictly dependent on Ficus (Moraceae) for reproduction. Overall, nonpollinating fig wasps have not received much consideration. Reliable phylogenetic and taxonomic frameworks are lacking for most groups, which hampers progress in our understanding of the evolution and functioning of fig wasp communities. Here we focus on Anidarnes Bouy cek (Sycophaginae), a member of the Neotropical fig wasp community. We present a detailed morphological analysis as well as the first molecular phylogeny of the genus inferred from two nuclear and two mitochondrial genes (Cytb, COI, EF-1α and 28S rRNA, 3937 bp). Twelve species are recognised, illustrated and a key to their identification is provided. Of those, only three were previously described and are redescribed here: A. bicolor (Ashmead); A. globiceps (Mayr) and A. brevicauda Bouy


Meter, in particular flowmeter having a measuring tube, wherein the measuring tube has at least one molded out of the measuring tube in the hot-forming nozzle to define a transducer, in particular an ultrasonic transducer, a measuring signal reflector, in particular an ultrasonic reflector, and / or a transmitter, and a method for manufacturing a measuring tube for a measuring instrument.


This paper presents the study of the oxidative behaviour of vegetable oils using Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) spectroscopic methods and thermogravimetric analysis/differential thermal analysis (TGA/DTA) techniques. The properties of vegetable oils were determined by their fatty acid (FA) composition. A high content of polyunsaturated FAs, like linoleic and linolenic acids, decreases thermal-oxidative stability. FTIR spectroscopy can be used as a quick method to measure the degree of unsaturation in vegetable oils in a qualitative manner. NMR spectroscopy can be used to quantitatively evaluate the degree of unsaturation in vegetable oils. TGA/DTA techniques were used to evaluate the oxidative properties of vegetable oils. In the present study, TGA/DTA analyses was performed on different vegetable oils under isothermal conditions at 150 °C for 3 hours. TGA/DTA thermograms showed weight changes and thermal activities in terms of exothermic or endothermic heat flows during the oxidative reactions. The oxidative degradation was evaluated in terms of the weight gain by the respective vegetable oils under the test conditions, due to the formation of oxidative polymerization products and the value of exothermic peaks as obtained from the DTA. The comparative study of the oxidative performance of different vegetable oils showed that the higher the degrees of unsaturation, the higher are the weight gains and the exothermic peaks. The evaluation of the effect of a chosen antioxidant showed marked improvement on the oxidative stability of vegetable oils. Copyright © 2008 John Wiley & Sons, Ltd.


Quantified multivariate polynomial inequalities - the mathematics of (almost) all practical control design problems. P. Dorato digital second order sliding mode control with uncertainties estimation for a class of SISO nonlinear systems, G. Bartolini et al development and identification of a hierarchical system of models for rapid prototyping of Si engines, I. Arsie et al identification of uncertainty models for robust control design, S. Malan et al second order chattering-free sliding mode control for some classes of multi-input uncertain nonlinear systems, G. Bartolini et al sliding mode output regulation of linear and nonlinear systems with relative degree one, L. Marconi et al output control of nonlinear systems with multiple discrete delays, M. Dalla Mora et al analytical synthesis of least curvature 2D paths for underwater applications, G. Endeavour et al modelling and control of nonsmooth hybrid mechanical systems, B. Brogliato global temperature stabilization of chemical reactors with bounded control, R. Antonelli, A. Astolfi detection and accommodation of second order distributed parameter systems with abrupt changes in input term - existence and approximation, M. A. Demetriou et al discrete-event models of manufacturing systems, E. Canuto optimization of internal forces in force-closure grasps, a. Bicchi et al loading parts and tools in a flexible manufacturing system, D. Pacciarelli. (Part contents).


Ring resonators can be used to efficiently filter, and drop, a series of wavelengths at the resonant frequencies of the ring. Both these properties are of use for astronomical applications. The dropped signal provides a frequency comb that can be used to provide a very accurate wavelength calibration. The free spectral range of such a device can be made much larger than that from a laser frequency comb, removing the requirement to perform subsequent filtering. The filtered signal could be used to efficiently suppress specific wavelengths, e.g. those corresponding to atmospheric emission lines. We present the expected performance of devices designed for both applications and discuss their advantages and limitations.


The design is in of constantly evolution, increasingly supporting by science and the knowledge gained with technological advances in the development of new products and a better understanding of its members. One of the important areas that q Design is allied neuroscience. This was able to reveal new possibilities to know and better understand the nature of cognition and human behavior. Thus is providing a scientific approach to the person and better understand the behavior, conditions and user interests against many situations, spaces or products. This study aims to understand the application of neuroscience in marketing disciplines,


The linearity of detection of tartaric and malic acids in grape juice was investigated for a single Aminex HPX 87H organic acid analysis column system. High levels of tartaric and malic acid resulted in a major drop in percent recovery. Using external standard calibration, based on peak height integration, the upper limits for column loading of grape juice samples were found to be 10 µg for tartaric acid and 30 µg for malic acid, above which recoveries dropped below 95%. A similar result was found using a synthetic juice containing glucose, fructose, and the two acids. Aqueous solutions of acids were found to be linear up to 25 µg tartaric acid and 130 µg malic acid. The reason for the drop in recovery under high acid conditions was not identified. Routine grape juice analysis required dilution of 1:10 to 1:20 to ensure accurate recoveries.


The paper presents a feature extraction method for signal classification tasks. The proposed method is based on linear adaptive Schur-like parametrization. The parametrization performance depends on a forgetting factor. The impact of forgetting factor, used in the adaptive procedure, on the quality of recognition was tested on well-known benchmark data.


The foreign-language newspapers and periodicals have enjoyed two booms in Chinese history,which differ greatly in almost every sense like the issuer,the social role,and the historical and political significance as well.For this very reason,the study in this area is usually separate and unsystematic.Few people touch upon the newspapers and periodicals between the two booms.Even fewer approach them from the perspective of press development.This paper aims not only at a comprehensive survey of the newspapers and periodicals in Chinese history,but also a study of their changing roles in society,their contributions to the development of the press,and the changing scenes in the international publicity of our country.


2 Abstract: With regard to social progresses and getting more important human rights, in addition to profitability, the responsibility of companies has become more important towards community and environment. Maximization of shareholder wealth and performing the duties of social responsibility can be considered as most important goal for companies. Efficiently performing corporate governance can have an outstanding role in achieving this goal. The purpose of this study is investigating the relationship between the corporate governance mechanisms and the social responsibility of companies listed at Tehran Stock Exchange. The samples used in this research were 70 listed companies in Tehran Stock Exchange which studied during the years of 2002-2010. Data related to the corporate governance variables were gathered through the financial statements of the studied companies and data related to the social responsibility was gathered through the Singhapakdi and et al standard questionnaire (2007) because of its high validity and reliability. In order to analyze data, the correlation test, regression and SPSS software were used. The research findings show that there is no significant relationship between the elements of corporate governance (i.e. Percent of independent outside directors on the board, free float, auditor type, institutional ownership and ownership concentration) and the social responsibility of companies. In addition, the research findings indicate that the independent variables (by either with control variables or without control variables) have no effect on dependent variable.


The invention relates to a method (71) for diagnosis of a heated exhaust gas sensor (11) of an internal combustion engine, in which by means of a voltage source (41, 51) a predetermined time varying or constant voltage (U time varying or constant current (I To provide a method (71) for diagnosing the exhaust gas probe (11) which allows a reliable and accurate diagnosis of the exhaust gas probe (11) and a statement of the type of any existing error in the exhaust gas probe (11) allows, it is proposed that the process (71) is carried out independently by a control and / or regulating device of internal combustion engine, wherein an operating temperature of the exhaust gas probe (11) by means of a separate by the control and / or regulating device regulating element (59) is controlled to a predetermined temperature value.


The introduction of a carsharing service reduces both private car ownership and total vehicle miles traveled. Due to the environmentally friendly modal shifts, policy makers are keen to increase market share of carsharing. While past research has focused on both the users of carsharing services and their general mode choice, little is known about access trips to vehicles of station-based carsharing services. However, because access to a mode is critical for its success, gaining insight into the way people experience access trips is an important step towards increased mode acceptance. In this paper we present model results based on a stated choice survey regarding access trips to carsharing stations conducted by users of a regional carsharing provider in Germany. After giving a brief overview of the conducted survey and the results of a descriptive analysis, we present the results of multiple multinomial and mixed multinomial logit models. Results of the multinomial logit models show that trip-related variables are the most important determinants for access mode choice, while only a few socio-demographic parameters are significant. We estimated mixed multinomial logit models to find out how consistent respondents answered across the choice situations. The results show that respondents were not always consistent across their choices and would, e.g. choose public transportation even if that entailed long distance travel or waiting times. Our findings are consistent with both research regarding public transportation access and the small pool of research regarding access of carsharing vehicles.


The article emerges from the debate concerning publishing in geography, especially regarding internationalism, the language of publishing, and the scope of geographical journals. English is the most common language of science – though only about 6% of the inhabitants of the earth speak it as a mother tongue. Increasingly, the evaluation of scientific activities is based on refereed publications in English at electronic databases (ISI, SSCI, etc.). In this article I consider the role of Geografiski Raksti/Folia Geographica (GRFG), a geographical journal published by the Latvian Geographical Society. In the GRFG a total of 53 articles by 51 different authors was published in 1999-2003. Human geographical themes dominate over physical geographical ones. The articles have been predominantly in Latvian (33) but all articles include at least a summary in English and there are also articles fully in English. English and Latvian make up a total of 84% of all references. Russian references are few and references in other languages are scarce. Language is significant in the production of particular geographical knowledge and geographical concepts are often best expressed in the mother tongue. GRFG is a unique arena for publishing geographical research in Latvian. Small languages contribute significantly in making great geography.


Relationship between the r 2 value and genetic distance for the linked SSR marker pairs for the seven subpopulations. The horizontal line indicates the 75th percentile determined for the distribution of the unlinked SSRs. (TIFF 766 kb)


Herodotus innovated boldly, sublimated the concept of history, created the historical narrative style, dealt with the relation between literature and history to a turn, and had some beneficial attempt on the other aspects. Some principles advanced by Herodotus spread and improved gradually; accordingly Herodotus deserved the title 揊ather of Historiography?.


Observation: We report an observation of a 54-year-old woman who had been consulting for nasal obstruction for one year without epistaxis. Nasal endoscopy revealed a polypoid mass, budding, pediculated, in the left nasal fossa. Imaging confirmed the presence of a relatively homogenous cystic hypodense lesion 5/3 cm from the left nasal fossa, extending to the jugular wall through maxillary osteolysis extending into the left maxillary sinus at the fluid straits in the last and pushing the nasal septum to the right.


An effect of local illumination on layered semiconductor heterostructures with 2D electron gas is investigated by measuring the spatial distribution of the photoreflectance and photoluminescence intensity varying the distance between the excitation spot and the probing position.


This is the third World Bank policy study of China's health sector. This report looks in greater detail at the impact of China's move toward a market economy on the financing and organization of health care and recommends a number of steps China can take to reform health care financing. It draws extensively on fifteen background papers prepared between November, 1994, and September, 1995. The report is arranged as follows: chapter one sets up the analytical framework for evaluating health finance policies by assessing the performance of China's health sector and examining the health policy issues it raises. The assessment uses four broad measures of performance: health status, financial access to health services, efficiency, and total cost. Chapter two examines the current state of health services and their financing, the rural health delivery system, sources and uses of health spending, fiscal barriers to bigger and more equitable health budgets, and health coverage in rural and urban areas. Chapter three reviews the status of public health programs; uses immunizations, tuberculosis control, and anti-tobacco efforts to illustrate in current public health programs; and suggests broad directions for change in health financing, program strategies, and content. Chapter four discusses how targeted health assistance might best be achieved and the likely costs of such assistance. It focuses on the rural poor, among whom absolute poverty is most prevalent. Chapter five reviews health sector efficiency issues, and proposes reforms in pricing, in the planning and coordination of infrastructure, and human resources that could significantly improve efficiency in both rural and urban areas. Chapter six explores options for efficient risk pooling in rural areas, specifically community financing. Finally, chapter seven proposes ways and means to pursue priorities in government health spending, and discusses their implications for the Chinese health care system.


The birth of infrahumanization is linked to essentialism. Ingroups were said to be the only ones with a full human essence. It was meant that ingroups were paragons of humanity. Almost like the Holy Spirit, essence has different definitions and can only be approached indirectly. The present paper insists on the fundamental (essential) differences between groups. It is proposed that if differences change, the groups (their essences) are seen as transformed. The second part of the paper looks for what makes differences crucial or essential. Variables are examined or proposed in terms of sufficiency and necessity. 'Which outgroups are infrahumanized' will remain an unsolved problem until sufficient and necessary conditions are discovered.


A problem for the Marangoni instability in a liquid layer subjected to an injection of ions is studied. The eigenvalue problem obtained after the linearization of the governing equations is solved by using the Runge-Kutta-Merson's method of fourth order. When an upper surface is deformable, we found that both stationary and oscillatory instabilities may occur. Two kinds of stationary instabilities have been detected. The corresponding critical wave number k, the Marangoni number Ma and electrical analog of the Rayleigh number Ra have been obtained numerically. Besides, we have revealed two types of wave instability: the gravity-capillar wave and thermocapillary wave with non-zero frequency /spl omega/ at k=0.


Continuous expansion in college student enrollment has promoted the development of higher education while it has meanwhile caused such new problems as wide sources of students, seriously uneven levels of students in the same class, etc. Grading teaching, based on the teaching concept of human-emphasis and student-cen-teredness and on the principle of teaching students in line with their aptitudes and needs, has reversed the passive situation and highly improved teaching efficiency. This paper attempts to deal with English grading teaching from different aspects, such as grading and evaluation system, free choices between teachers and students, flexible adjustments, etc.


Metal etching technology is a technology with a long history, which is both old and advanced, both ordinary and sophisticated. With the development of new technologies and the exploitation of new products, metal etching technology is playing a more and more important role. In this paper, metal etching principle is introduced, besides the classification of this technology, the produce processing, application examples, the main problems and prospects are described.


Differential linear energy spectra of a flare- produced proton beam compared with a neutron- produced recoil proton and a monoenergetic proton


DOI, Digital Object Identifier, has been pervasively applied in digital information resources overseas and becomes an international standard, while in China it's still on the initial stage. This article discusses the application of DOI in the digital publication of Chinese sci-tech journals, and analyzes the problems, such as inadequate attention, lack of engagement, unsatisfactory application and so on, as well as the countermeasures. Giving the lifting effects of DOI on the digitalizing and networking of Chinese sci-tech journals, journal articles should be registered on DOI for the display degree and citation rate.


MCPET/PTT hybrid fibers were prepared by blending and melt spinning of PTT and MCPET pellets that had been made by researchers.Fourier transform infrared spectroscopy(FT-IR) was used to characterize the molecular structure of MCPET/PTT hybrid fibers,and no significant peak shift or generation of new peaks was observed on the FT-IR spectrum,indicating that no transesterification reaction and terminal group reaction occurred between MCPET and PTT.The compatibility of MCPET/PTT hybrid was studied by differential scanning calorimetry(DSC),dynamic mechanical analysis(DMA),wide angle X-ray diffraction(WAXD) and SEM.DMA and DSC results showed that MCPET has good compatibility with PTT in the amorphous region;WAXD study indicated that the crystalline region is partialty compatible;and SEM micrographs of the cross-section of fiber blends indicated that MCPET/PTT hybrid has good compatibility.


We report measurements of charged current inclusive and quasielastic interactions of muon neutrinos on carbon with an average energy of 0.8 GeV by SciBooNE experiment at Fermilab. These two results are complementary to understand the neutrino‐nuclear interaction in the few‐GeV region with effects of final state interactions.


This study deals with a new strategy of the re-assignment for multi-robot seamless coverage tasks using the concept of propagation in a multi-robot surveillance system (MRSS). In the context of MRSSs, multi-robot coverage tasks play a critical role. These tasks require generating paths for two or more robots to cover an entire area, with the objective of minimizing the time needed to complete the task. However, over time, robots may need to be excluded from coverage missions due to issues such as battery charging or malfunctions. It is important to handle these situations efficiently in order to maintain the completeness and balance of the coverage mission. Typically, it can be resolved by either recomputing the coverage algorithm for the remaining robots or redistributing the coverage task of the excluded robot to its neighbors. However, in the proposed method, the amount of coverage area of the excluded robot is equally and efficiently assigned to the remaining robots. First off, a relational graph between robots and a tree based on the excluded robot are sequentially constructed to necessarily know how the robots are geometrically arranged in the given area centered on the excluded robot. The excluded robot becomes the root of the tree, and the depth of the tree indicates the proximity of the coverage areas. Subsequently, the amount of the original coverage area of the excluded robot can be differently assigned to its nearest neighbor robots according to the size of the subtree. Then, the coverage area of the robots corresponding to the second level of the tree are added from the partial coverage area of their parent robot to keep their coverage area balanced, respectively. The similar process is continuously performed, such as 'propagation', until the re-assignment of the coverage area over the leaf nodes is complete. Finally, balanced coverage area is re-assigned to the remaining robots, which is time-efficiently computed. Simulations were performed on two occupancy grid maps that were acquired from a simultaneous localization and mapping method. The proposed method was evaluated against conventional methods on three factors such as the balanced re-assignment of the coverage area (Balancing), the variation of the individual coverage area before and after the re-assignment process (Seamless Coverage), and the total computational efficiency over time (Time-efficiency). The coverage area was uniformly re-allocated after the proposed method was applied. In addition, the proposed method had a short calculation time and enables seamless coverage even after re-allocation. In the future, probabilistic maps related to the importance rate, accident rate, and crowds in the coverage area will also be taken into consideration.


The aim is to study the effect of comorbid pathology, namely, diabetes mellitus, on free radical oxidation in the mitochondria in the heart cells in female rats with experimental Guerin carcinoma.


The influence of temperature, storage time and the addition of hydrochloride L-cysteine in the preservation of the fungicide mancozeb was studied under field conditions in the surface layer of a Cambisol collected in an area planted with cabbage in Nova Friburgo - RJ, Brazil. The results of this study showed an efficiency of up to 42% in the preservation of the fungicide in the samples treated with cysteine and stored at low temperatures compared to those not treated and kept at room temperature


We investigate the magnetic properties of a heterostructure comprised of alternating metallic and Mott insulating layers of fermions with varying interlayer hybridization. Results from large-scale quantum Monte Carlo simulations at half-filling show clear evidence of induced magnetism in the metallic layers due to coupling to the Mott insulating layers at small to intermediate values of interlayer hopping. The in-plane magnetism is completely suppressed via a Kondo proximity effect when the coupling between adjacent layers is increased beyond a critical strength. The nature of the phase in the Kondo-like insulating regime is investigated and is shown to be dominated by simultaneous in-plane and interplane short-range correlations.


A new approach for numerical modelling of microwave susceptors used as an active element in packaging of microwaveable food products were investigated. The accuracy of the method was validated in the case of estimation of reflected, absorbed, and transmitted power for the susceptor in free space, where the exact solution is known. Further, the amount of power absorbed by the susceptor was calculated for the case of the susceptor attached to the cylinder made of water. The influence of the position and size of the cylinder was considered. The amount of power absorbed by the susceptor and the cylinder were calculated.


Objective
The incidence and distribution of positional deformities(PD)were studied by measuring cranial types of infants aged 0-6 months of 3 hospitals in Chongqing, and the recommended values of local PD were discussed.

Methods
Data of 3 406 infants with 0-6 months head size measurements were collected from the Second Affiliated Hospital of Army Military Medical University, Yongchuan Maternal and Child Health Care Hospital and Wanzhou Maternal and Child Health Care Hospital from September 1, 2017 to August 31, 2018, cranial vault asymmetry(CVA)and cranial index(CI)were calculated.According to different age groups, observe the distribution of cranial types, and use the current international common diagnostic criteria to understand the incidence of cranial abnormalities, and analyze the distribution of percentile values of CVA and CI in infants in Chongqing.

Results
According to the current international standard diagnosis of PD, the incidence of simple brachycephaly was the highest(39.9%)in the overall cranial abnormalities of infants, followed by brachycephaly with plagiocephaly was the second(36.1%), simple plagiocephaly was the lowest(6.9%), and normal cranial type only accounted for 17.1%.The detection rates of plagiocephaly(36.9%)and brachycephaly(67.0%)were the lowest in the 0-2 months group, and the highest in the 3-4 months group(47.3%/83.3%), and then decreased in the 5-6 months group(46.6%/80.2%).

Conclusion
The basic values of cranial type measurement of full-term infants in chongqing were significantly different from international reports, mainly due to the large CI value.The general international diagnosis standard for positional deformities do not conform to Chinese infants.We suggest that the reference value for positional deformities in this region is as follows: CVA≥0.4 cm is abnormal, of which 0.4 cm≤CVA<0.6 cm for mild plagiocephaly, 0.6 cm≤CVA<1.0 cm for moderate plagiocephaly, CVA≥1.0 cm for severe plagiocephaly; 82%≤CI≤91% is abnormal, of which 91%≤CI<94% for mild brachycephaly; 94% ≤CI<99% for moderate brachycephaly; CI≥ 99% for severe brachycephaly.CI≤82% is scaphocephaly.

Key words:
Positional deformities; Plagiocephaly; Brachycephaly; Normal values


The lack of knowledge of farmers and the unequal counseling about onion disease from experts is a strong reason for the difficulty of overcoming or immediately treated diseases of onions, for this requires early diagnosis of disease onion plants. This research uses the Certainty Factor method. This method uses the certainty of an expert on the symptoms of each disease. By determining the value of MB (Measure of Believe) as the level of confidence in the hypothesis and MD (Measure of Disbelieve) the level of distrust of the hypothesis. After using the Certainty Factor formula, the value of each disease will be generated from the new symptoms owned by using the highest value of each disease, so that is the result of disease diagnosis in shallots. This study uses as many as 35 data as testing and from these data obtained an accuracy value of 85.71%


(51) Int. Cl." ..................................................... C11D 17/00 (52) U.S. Cl. .............................................................. 510/424 (57) ABSTRACT A new general purpose foaming agent having application as drilling fluid foaming agents or as any foaming agent needed an a wide variety of applications is disclosed, where the agent includes at least one anionic Surfactant, at least one cationic Surfactant, and mixtures thereof and one or more Zwitterionic compounds. A method for using the foaming agent in capillary coiled tubing application is also disclosed. The foaming agents can also include additive to augment the properties of the foaming agent for a given application.


A plastic window assembly for use in a motor vehicle has a plastic panel and a motor. The motor is coupled to a gear and is operable to drive the gear to move the plastic panel in a first panel direction and in a second panel direction. In one variation, the plastic panel has portions forming at least one gear track to define a gear path. In another variation, the window assembly has a frame, and the frame has portions defining a track. The track has a central section and a terminal section, the central and terminal sections intersecting and being non-collinear. In another variation, the plastic window assembly has a flexible strip. A first end of the flexible strip is connected to the gear and a second end of the flexible strip is connected to the plastic panel.


To further study the effects of glucocorticoids and thyroid hormones in fetal lung, we cultured human lung (16-22wk) for 4-8d as explants in serum-free Waymouth's medium with 95% air/5% CO2. Effects of dexamethasone (Dex, 10 nM) and T3 (2 nM) on phosphatidylcholine (PC) synthesis varied with precursor (Table).The additive hormonal effect occurred over a range of choline concentrations, did not alter the distribution of label among acid-soluble precursors, and correlated with tissue saturated PC content. Dex, but not T3, altered the distribution of precursor among phospholipids; compared to controls, glycerol incorporated more into PG (13.5 vs 4.9%) and less into PI (13.1 vs 18.9%), and acetate incorporated more into PC (81.5 vs 73.1%) and less into sphingomyelin (2.1 vs 6.3%). By electron microscopy, epithelial cells of treated explants showed less glycogen, many mo amellar bodies, and proliferation of microvilli. We conclude that low concentrations of glucocorticoids and thyroid hormone stimulate surfactant production in fetal lung in the absence of serum or other hormones. The two hormones appear to act at different biochemical sites to produce a synergistic response.


Fractures play a significant role in the transmissibility of the Hanifa reservoir at Abqaiq Field. The Hanifa is a Type 2 fractured reservoir characterized by a finely-crystalline carbonate matrix which contains most of the reservoir storage porosity, and a stylolitic fracture system which provides essential permeability. Comparisons of over 5000 fractures identified from core and borehole image data with open-hole log data showed that porosity is negatively correlated with fracture density and mechanical rock strength. From these relationships, it was possible to utilize additional wells where porosity log data was available to calculate fracture densities. These wells were used to generate matrix porosity and permeability as well as fracture density attributes in a 12-sequence, 29-layer geocellular model. The effect of structural curvature on fracture intensity in the reservoir was estimated by mapping the derivative of structural dip. Incorporation of structural curvature explained variations in well test behavior not predicted by initial estimates of fracture density from porosity alone. Resultant fracture permeabilities compared favorably with well-test derived productivity indices. Three-dimensional visualization of model attributes showed that a monotonous and low ( 50 md) permeabilities of the fracture system.more » Reliability of the geocellular model to predict fracture densities and associated permeabilities has been confirmed by subsequent drilling of high cost horizontal wells, and is being used in reservoir engineering and development drilling planning efforts.« less


This is a collection of fourteen previously unpublished papers on the fit between semantic externalism and claims about self-knowledge. Philosophers of mind as well as epistemologists, especially those interested in the transmission of warrant, will find this collection worthwhile. Exactly how worthwhile depends on what aspects of the topic one is interested in. To help potential readers make their own determination, I will discuss the first five papers in some detail then I will briefly catalogue the remaining papers. This is appropriate since the first five papers are all nicely focused on a single issue, while the other nine papers address an assortment of issues. take up an issue stemming from McKinsey's seminal 1991 Analysis paper, " Anti-Individualism and Privileged Access. " There, McKinsey offered a reductio against the conjunction of two claims. (1) I can know a priori the content of what I am thinking. (2) Externalism about thought contents is, as a matter of logical necessity, true. (1) has it that without investigating the external world by the usual empirical means, I can know, for example, that I am thinking that water is wet. A


Objective To study early diagnosis of Alport′s syndrome (AS) in the patients with thin basement membrane nephropathy(TBMN) by detecting the distribution of α chains of Ⅳ collagen in the epidermal basement membrane (EBM) and the glomerular basement membrane (GBM). Methods Twenty-one patients,diagnosed as TBMN that all had the family history,detected the distribution α chains of Ⅳ collagen in EBM and GBM by indirect immunofluorescence. Results α 1 α 5(+) in EBM was continuous, α 1 α 3 α 5(+) in GBM was continuous in 18 cases. One of the other 3 cases was a boy with typeⅡnephropathy, α 1(+) in EBM was continuous , α 5(-) in EBM;α 1 (+) in GBM was continuous, α 3 α 5(+) in GBM was discontinuous.Other 2 cases were girls with isolated hematuria ,α 1(+) in EBM was continuous,α 5(+) was discontinuaus; α 1(+) in GBM was continuous, α 3 α 5(+) in GBM was discontinuous. Three cases were diagnosed as AS (14.29 %). Conclusion To detect α 1,α 3,α 5 chains of EBM and GBM in patients with TBMN can early diagnose AS.


In the present investigation an apparatus for underwater explosive compaction of Al composites is developed. To evaluate the performance of the apparatus, underwater shock pressure was measured using manganin‐gauge and the pressure was also estimated through numerical simulation. The measured pressure showed good agreement with the simulated one. The applied pressure can be controlled easily by varying the height of water column in the apparatus. Since the impacting explosive pressure is not very high (5–15 GPa), the possibility of synthesizing various defect‐free aluminum based composites is explored. The dynamic characteristics of the shock consolidation apparatus is corroborated by the high strength defect‐free compacts.


The article considers the modern direction of management decision-making - ensuring economic security. The current situation has radically changed the managers' approach to this issue, and on the basis of developed scientific and informational sources, we outline the shift of the discussion from the discussion of the feasibility of ensuring economic security to specific decisions on its provision. The main purpose of this research is to consider economic security at various institutional levels, to determine the main factors of its formation and to study the impact on this process of innovative development. It has been established that economic security is the key to long-term development and security, and therefore its support and formation is an urgent task for research. It is considered at different levels of management: state, regional and enterprise level. The main signs of economic security of the enterprise are determined: economic Innovations in the system of strategic management of the security of the national economy in conditions of risks and uncertainties of globalization essence of the economic security of the region was studied and it was stated that it is not possible to standardize the approach to the formation of the economic security of the regions, because each of them is unique and requires an individual approach in view of the geographical location, specialization, resource potential and economic opportunities. The comparison of the main elements of the economic security in the country and regions is presented in the following areas: economic independence/autonomy, sustainability and stability of the national economy, the ability for self-development and progress. The essence of innovative activity is considered, taking into account the approved definitions in the regulatory and legislative acts of Ukraine. It was determined that it is impossible to activate innovative development without studying the foreign experience of innovative activity, namely the analysis of models of innovative development of the economy of the leading countries in the world, and based on the study of this direction, tools for activating innovative development in foreign countries were systematized. Prospects for further scientific research, in particular, innovative development as the basis of the formation of economic security, and the mutual influence on the formation of economic security of three levels: the state, regions, business structures requires further research, were identified.
Keywords: innovative development, economic security, business structures, regions, state administration, competitiveness.


In mine auxiliary shaft,the people in waiting room do not know the hoist state. So proposes one state control system,that is installed the speech display in the waiting room exit,which can real-time display the auxiliary shaft hoist state. The voice hint and subtitles scroll remind the waiting people to line. This system applies well in site and guarantee the safe hoist of auxiliary shaft.


Marriage and family common factors are used to understand the curative elements in marriage and family therapy (MFT) models of treatment. Sprenkle, Davis, and Blow identified four common factors of well-established MFT treatment models. This article deconstructs Imago relationship therapy (IRT), a widely used model of couples therapy, for the purpose of determining whether IRT utilizes the four curative common factors of MFT in its theory and practice. The analysis indicates that IRT does utilize the four broad common factors of MFT shared by other well-established models of MFT in addition to its narrow model factors that make it unique.


Potential of secondary metabolism (production, persistence and effectiveness) of an organism has diversity that is commonly caused by genetic or environmental factors. The diversity of secondary metabolites potential can be occur because of differences in population, life cycle, time of cultivation, soil, climate, and geographic condition. In the process of cultivation, to obtain effective secondary metabolite compounds, it must be supported by appropriate habitat. The aim of this study was to determine the content of phenolic compounds in Pluchea indica from some altitude habitats. This study was a descriptive research. P.indica leaves samples was obtained from Bangkalan for lowland (28.3-31,72 m asl), Dlundung - Trawas for middle-altitude land (727-937 m asl), and in Coban Talun – Batu for highland (1303-1322 m asl). Simplicia of P.indica leaves was macerated and extracted by dissolving in methanol, ethyl acetate, distilled water, and n–butanol. Total polyphenol (gallic acid/GAE) contents was determined using UV - VIS spectrophotometer. Result of the study showed that content of phenolic compounds (gallic acid) on P. indica in Bangkalan/lowland (0.441 mg/g) was higher than P. indica growing in Trawas/middle-altitude land (0.364 mg/g) and in Batu/highland (0.303 mg/g). Phenolic compound characteristic was mostly semi-polar which was indicated by the largest total phenol in ethyl acetate fraction (0.412mg/g bk).


Traffic engineering and QoS guarantee mechanism of MPLS(Multiprotcol Label Switching) Network structure were analysed.With TCP and UDP designed as Service Model under IPV6 network on Linux Operating System,the simulation for No-MPLS network and MPLS network was performed by NS2 platform.And Qos performance of MPLS network was analysed with the metric of throughput,end-to-end delay,jitter,packet drop rate and so on.The experiments prove that the performance of network can be further optimized by using MPLS-TE technology in IP network.


Wade Brown, The God-Inspired Language of the Book of Mormon: Structuring and Commentary. Clackamas, OR: Rainbow Press, 1988. x + 988 pp. $19.95. Reviewed by· Donald W. Parry Wade Brown, Institute instructor and doctoral candidate at the University of Idaho, has endeavored in this work to format the entire text of the Book of Mormon into various parallelistic and poetic structures. Brown's chief aim is to show that all parts of this sacred book (including the testimony of the three and eight witnesses) consist of Hebrew poetry. His claim is that "over 6,000 identifiable examples of parallel or poetic structures which are common to ancient Hebrew writings" (p. v) exist in the Book of Mormon. Additionally, to assist the reader in understanding poetic verse, the author has included a commentary, which consists of a brief "Note of Explanation" found in the preface, and a series of explanatory and demonstrative footnotes. However, Brown's comments make up only a small portion of the book. The 988-page book consists primarily of scriptural text. In order to prove his supposition that the entire Book of Mormon is composed of parallelisms and poetry, Brown has arranged and systematized the printed text of the Book of Mormon into a series of intricate indentations. The author explains that "in this volume the parallels will be visually demonstrated by indentation. When lines begin at the same point across the page it is proposed that there is some way in which those lines correspond to each other" (p. 1). For example, 1 Nephi 13:26 is arranged in a chiastic pattern as


This project investigates the effect of microcapsule size on the mechanical properties of a self-healing polymer composite. Three different sets of tensile bars were made from an epoxy with each set containing a different size microcapsule at a fixed concentration. Uniaxial tensile tests were performed to determine Young's modulus and ultimate tensile strength. It was found that Young's modulus decreased as microcapsule size increased. No correlation was found between ultimate tensile strength and the microcapsule sizes tested.


A previously healthy 11-year-old boy complained of 3 days of discomfort in the left lumbar region, left buttock, and posterior thigh. He had had an upper respiratory infection forthe previous 2 weeks and had been fallen on by another player, without apparent injury, during a hockey game on the day pain began. The next day, his parents noted he was limping. Physical examination revealed a hyperlordotic lumbar spine with paraspinal muscle spasm and limitation of movement. A small dermal sinus was present in the natal cleft. Straight leg raising was limited to about 45#{176} bilaterally by back and buttock pain. There was mild motor weakness in the left leg for knee flexion and ankle dorsiflexion. Plantar flexion and hip extension were even weaker and the extensor hallucis longus could not overcome gravity. The left ankle jerk was slightly but consistently diminished. There were no sensory findings. Anal sphincter tone was normal and a normal anal reflex was present bilaterally. Lumbar myelography revealed no abnormality. Epidural yenography (fig. 1) demonstrated a collection of irregular, bizarre vessels projecting to the left of the theca at the L5 level. This was interpreted as a venous vascular malformation. The epidural venogram was otherwise normal. A laminectomy was carried out from L4 through 51 . The dermal sinus was excised to the level of the sacral hiatus. A large blue mass of blood vessels lay extradurally, on the left, between the axilla of the L5 nerve root and the shoulder of the 51 nerve root. The vessels continued distally around the L5 nerve root sleeve in circumferential fashion. An attempt to excise a portion of this mass of blood vessels between hemostatic clips was unsuccessful because of the confinement of space and copious bleeding. A sinusoidal vessel in continuity with this collection of vessels ran down into the L5 vertebral body. The abnormal blood vessels were excised with the aid of the bipolar cautery and the sinus opening into the vertebral body was occluded with bone wax. Further bone removal was carried out at both foraminal levels and both root sleeves were inspected to ensure that there was no residual compression. Postoperatively, there was a steady regression of the patient's signs and symptoms. Motor power had returned to virtually normal in all muscle groups 20 months after surgery and there were no other neurologic abnormalities. Epidural venography has been used increasingly to complement and, in some cases, to obviate myelography, particularly in the assessment of L5-S1 disc disease where a large space frequently exists between the backs of the vertebral bodies and the anterior limit of the spinal subarachnoid space. Venography is also more sensitive than myelography in cases of posterolateral disc herniations in the presence of a narrow transverse diameter of the subarachnoid space. Our case had an epidural vascular malformation producing a mass effect on the L5 and Si nerve roots, clinically simulating


Comparison of SP2 and SP3 generations of soybean cultivar Shennong 8 with the check was carried out in the field for the effect of space mutation on leaf morphology and physiology.The results showed that space mutation enlongated the petiole length at different canopy layers(upper layer 4.27%,middle layer 2.83%,low layer 2.73% over check),narrowed the leaf angle,increased the leaf greenness,leaf photosynthesis rate,and decreased the transpiration rate.For example,in SP2 generation,leaf photosynthesis rates were 17.53-23.70μmolCO2·m-2·s-1 at blooming stage,15.50-23.00μmolCO2·m-2·s-1 at podding stage,24.30-31.50μmolCO2·m-2·s-1 at seed filling stage.The transpiration rates were 4.48-7.45 mmolH2O·m-2·s-1 at blooming stage,4.62-8.48 mmolH2O·m-2·s-1 at podding stage,5.31-8.05mmolH2O·m-2·s-1 at seed filling stage.


The iron-making process of high-phosphorus iron ore by oxygen top-blown smelting reduction was studied, the effects of slag basicity, molar ratio of carbon to oxygen, smelting temperature, oxygen blowing time (oxygen purity at 99%) and oxygen flow rate on phosphorus distribution in the process were investigated. The results showed that the phosphorus in the molten iron decreased with the increase of temperature. However, excessive temperature led to rephosphorization phenomenon. Dephosphorization rate was enhanced as rising of slag basicity, oxygen-enriched rate and time of oxygen application within a certain range. However, the dephosphorization rate declined with rising of molar ratio of carbon to oxygen. The optimum conditions were: 1550℃, molar ratio of carbon to oxygen 1.0, slag basicity 1.1, oxygen purging time 10 min, and oxygen flow rate of 250L/h. Under these conditions, the phosphorus content in the molten iron was 0.068%, and the dephosphorization rate up to 92%. The resulting pig iron could be used in steel-making.


The invention discloses an accurate measurement and calculation method for parameters of a power transmission line. In the method, the parameters of the power transmission line are accurately calculated according to short-circuit impedance ZS and open-circuit impedance ZO of the power transmission line. The method comprises the following steps of: measuring the short-circuit impedance ZS and the open-circuit impedance ZO of the power transmission line with length of D; acculate calculating characteristic impedance zc and propagation coefficient gamma of the power transmission line according to a calculation formula provided by the invention; further, calculating impedance z and admittance y under the condition of unit length of the line through the formulas of z=zc gamma and y=gamma/zc; and accurately calculating impedance Z' and admittance Y' of an equivalent pi circuit of the power transmission line according to the calculation formula provided by the invention. By adopting the measurement and calculation method provided by the invention, the accuracy for the parameters of the power transmission line can be greatly improved, manpower and material resources are saved, tide current of a power system is stably analyzed; protection setting is performed; and fault positioning is more accurate.


My adventure in the world of epilepsy started during my MSc, where I met Dr David Carmichael at University College London. I picked him as my supervisor because he is the expert in the combination of electroencephalography (EEG) and magnetic resonance imaging (MRI). At that time, I was interested in becoming familiar with how these techniques could be used simultaneously. At the same time as learning about two neuroscience techniques, I also learnt about one of the main applications: epilepsy. Seeing how unpredictable seizures are, and the impact that epilepsy has on small children at Great Ormond Street Hospital in London, made me determined to be part of a community that can help understanding this condition. I was puzzled that epilepsy could be such an old condition and yet we still do not understand it completely. I wanted to help! So, I got a studentship for my PhD via the Biomedical Research Centre at King's College London, where I met Professor Mark Richardson. Given my amazing collaboration with Dr Carmichael, I decided to create a joint force between King's College London and University College London to develop ideas for future research in epilepsy.


Abstract Disclosure: E.M. Pinto: None. E. Lalli: None. G. Wu: None. R. Ribeiro: None. G. Zambetti: None. Pediatric adrenocortical tumor (ACT) is an uncommon malignancy frequently associated with Li-Fraumeni syndrome, a familial cancer predisposition disorder caused by germline mutations in the tumor suppressor TP53. ACT is also associated with other genetic constitutional disorders, such as Beckwith-Wiedemann syndrome (BWS) which results from the deregulation of a gene cluster on chromosome 11p15. We report here the identification of three pediatric patients with ACT and additional tumors, two of which received a clinical diagnosis of BWS. Family histories of these two probands include multiple unsuccessful pregnancies. All patients have wild-type TP53 sequence and no evidence for germline chromosome 11p15 alterations. Molecular analyses by whole genome sequencing revealed genome-wide copy neutral loss of heterozygosity (cnLOH) in all tumors. Microsatellite STR and MS-MLPA confirmed genome-wide cnLOH with the selective loss of all maternal chromosomes and duplication of paternal chromosomes in each tumor. Analysis of skin fibroblasts showed mosaic paternal uniparental disomy with partial LOH for all chromosomes, while no LOH was detected in blood DNA. The most prominent clinical feature of genome-wide cnLOH is an unbalanced monoallelic and parent-of-origin specific expression of imprinted genes known as multilocus imprinting disorder (MID). MID has been associated with maternal-effect variants that alter the maintenance of methylation at germline-derived differentially methylated regions (DMRs) in early embryogenesis. In addition, causative trans-acting factors in imprinting disorders, including the subcortical maternal complex (SCMC), have the potential to affect multiple DMRs across the genome, resulting in a multilocus imprinting disorder. Our study identifies three pediatric patients who developed ACT and other tumors that have undergone genome wide cnLOH that specifically selected against all maternal chromosomes. None of three patients presented with germline alterations in TP53 or 11p15, typical of pediatric ACT. WGS data revealed a germline mutation (p.M573T) in the histone methyltransferase NSD1 in the mother of patient #2. NSD1 mutations are reportedly associated with recurrent miscarriages, tissue overgrowth and increased cancer risk. Alterations in other epigenetic regulators, such as SETD1B (p.R226C), a component of a histone methyltransferase complex and TNRC18 (p.P454L), that enables chromatin binding activity were observed in both mother and child in each family. Further analysis of maternal-effect variants associated with abnormal pregnancies and MID will be important for understanding the mechanisms underlying genome-wide cnLOH. Our results support the molecular testing of multiple loci in atypical clinical presentations of patients with pediatric ACT. Presentation: Saturday, June 17, 2023


This book reports the proceedings of a May 1976 conference entitled "Implications of Basic Speech and Language Research for the School and Clinic," the sixth conference in the Communicating by Language series, sponsored by the Growth and Development Branch of the National Institute of Child Health and Human Development. Although the National Institutes of Health are traditionally associated with fundamental research, there has been growing public pressure for improvement in the communication of relevant laboratory research to the teacher and clinician. This conference brought together some of the country's foremost researchers and clinicians in an effort to examine both the present state of research in speech and language and how communication of that research to those concerned with its practical application might be improved.The book proceeds from the more "physical" problems of speech perception and production to the more cognitive problems of language meaning and memory. A summary of current knowledge about each topic is presented by a basic researcher, followed by a discussion from the clinician's point of view. The topics include all aspects of language processing in both adults and children, including physiological and acoustic aspects of the speech signal, perceptual processing and memory for speech and language, and processing syntactic and semantic information in sentence comprehension and lexical memory. A final paper reflects on selected themes of the conference and summarizes what the participants learned about the relation of basic research to areas of application.


The main purpose of this paper is to express a general formulation for the theoretical analysis of longitudinal elastic wave propagation through a general and in particular the T and十 junctions. The bar joint is modeled as a rigid block. The bars are assumed to be all of the same thickness but may differ in width and may be of different materials. Elementary theory is applied to investigate the propagation of longitudinal wave. The present study indicates that for a T junction there would be no transmission of the longitudinal elastic wave. For a 十junction there would be no transmission of the longitudinal elastic wave into the perpendicular branches but the transmission into the horizontal bar was happened.


The beam combiner of an astronomical long-baseline interferometer combines the two beams of starlight to form white-light fringes. We describe beam combiner in the SIM PlanetQuest Spectral Calibration Development Unit (SCDU). In addition to forming white light fringes, the beam combiner provides other functions such as separating the light for guiding, fringe tracking, and science measurement. It is designed to function over the optical bandpass 450-950 nm. Coating design is critical to beam combiner as residual dispersion and mismatches affect the ability to accurately measure the position of stars of varying spectral types.


The present invention relates to a vehicle restraint system to deploy from the storage position to the arresting position (8, 8 '). The expansion may be inflated with a gas pressure source, holding volume for restraining the occupant to move 'subjecting, at least one support structure (1,11,11 (13, 13)', 12, 12 ' ) is carried out by. Retention volume (13, 13 ') is surrounded by at least one retaining structure. An object of the present invention, as restraint system is adapted to the respective load state is to improve the restraint system, by sending gas to a support structure (1,11,11 ', 12, 12'), the flexible support structure for surrounding the holding volume (7, 7 ') so that can be lifted.


Florentine martyr. Maxime, although shut up in a convent, lived many years, long enough to leave us a body of writings that are primary for the study and understanding of the period when all the windows of Russia were wide open to Europe. Then, at die end of the sixteenth century, the extinction of die dynasty of Rurik and the advent of "troubled times" brought the "iron curtain" down once more on the second act of Russian history. With Romanoff's advent in 1613 and throughout the reign of Peter die Great, Russia was enabled to reopen her windows to Europe. These windows remained wide open for three centuries, down to 1917, when the iron curtain was lowered again for the third time.—ALEXANDER OLEROFF


Infno is an algorithmic generator of electronic dance music (EDM) and synth pop fully implemented in Super-Collider 3, the latest generative music work in a line of `Infinite Length Pieces. The program attempts to model the production of electropop and dance music styles with a closer union of parts than typical in many previous algorithmic composition systems. Voices, including a percussion section, bass, chord and lead lines, are not independently created; the parts, generated in any order, are influenced by underlying harmonic ideas, rhythmic templates and already generated lines. In particular, dynamic programming is used to select melodic lines under cost constraints of register, harmonic template, existing voices and voice leading heuristics.


EXPERIMENTAL work during the past fifteen years has shown that phenomena similar to those elicited by stimulation of sympathetic and parasympathetic nerves can be obtained by appropriate stimulation of a region of the brain forming the lateral walls and floor of the third ventricle. This region is known as the hypothalamus.


This study examines the process of lateralization of syllable final / r / in Puerto Rican Spanish. In addition to analyzing the process in oral speech, this study takes into consideration written registers as well. The results show that the process of lateralization goes beyond oral registers among Puerto Rican Spanish. However, the manifestation of the lateral variant does not only occur as a result of neutralization or confusion between 'r' and 'I.' There seems to be a ludic function and evident intentionality in the use of lateral variant, that in some ways shows a mark of identity among Puerto Rican speakers. The study incorporates written samples from several individuals as well as examples from Facebook.


A radiation Source assembly and transducer incorporating Same are Suitable for use in measuring spectral absorption properties of a Substance to be analyzed, Such as a gas. The radiation Source assembly has an optical axis. A measuring radiation Source provides radiation in the direction of the axis and a reference radiation Source provides radiation in the direction of the axis. An optical diffuser is spaced from the radiation Sources along the axis. Radiation from the measuring radiation Source and radiation from the reference radiation Source are applied to the diffuser and the diffuser forms an exiting radiation beam for the assembly from the radiation of the measuring radiation Source and reference radiation Source. The exiting radiation beam extends along the axis. In at least a portion of a cross-section of the exiting radiation beam taken perpendicular to the axis, the configu ration of the distribution of the radiation from each of the Sources as Seen by a detector in generally the Same So that the operation of the radiation Source assembly resembles that of a single-path photometer. The transducer further includes the detector for receiving the exiting radiation beam after it has passed through the Substance. The assembly and transducer may also include optical collecting and concen trating devices for directing radiation to the detector.


A system is called reactive, if its role is to maintain an ongoing interaction with its environment. A reactive system changes its actions, outputs and status in response to the input it receives from outside. Reactive systems are used in performing several crucial tasks, where the input that is given to them is vast and, most importantly, unpredictable. In this paper, we propose the specification and verification of reactive systems. The approaches to specification and verification of reactive systems which are different from computational systems are discussed. We have presented the Kripke structure or fair transition system and temporal logic that are most well known techniques for specifying system their properties. Verification can be done through model checking or deductive verification technique depending on the type of reactive system.


The present invention relates, wherein the warning area for a vehicle parking at the exit, in particular pulled out backward parking (5) Method transverse transport (7) of the motor vehicle at least beware trailing side of the corner portion having potential for detecting lateral region remote traffic sensors (8, 9) and the proximity of an area sensor for detecting the vehicle surroundings near side, and wherein, when the at least one detection sensor to a remote region of the transverse transport when, a warning is generated, the method comprising the following steps: observation of the vehicle when the parking space near the exit side of the surrounding environment; the results detected by the measuring region the proximity sensor is a remote region of the transverse field of view having a free traffic; and If one or both regions remote sensors do not have freedom of transverse field of view of traffic, generating a prompt (17) at the driver.


. We answer a question of Semmes: A Jordan curve r admitting a quasiconformal reflexion, which is "conformal" near T in a sense given pre-cisely by a Carleson measure condition, is necessarily rectifiable.


The invention discloses a method and system for carrying out information issue adjustment according to information resource hot spots. The method includes the steps that data of quantity of demand of different information platforms for information resources are monitored and recorded, the data of quantity of demand of all the information platforms are quantized, and service demand factor information of all the information platforms is generated; publishing amount data of different types of information resources are acquired from issuing servers of the information resources, service demand factor information hot spots, corresponding to the information resources, of the information platforms are quantized, hot spot factor information of various types of information resources is generated, hot spot factors of the information resources are divided according to the areas to which the information platforms belong, and area hot spot factor information of the corresponding areas is generated; sampling fitting processing is performed, area hot spot reference data of the corresponding areas are obtained, and the issuing amount of the information resources on the information platforms in the areas is adjusted. The method and system solve the problem that because accurate quantized data are lacking in analysis and prediction of fluctuation characteristics of the information resources in different areas, the information issuing is difficult to adjust.


Verbatim queries submitted to search engines often do not sufficiently describe the user's search intent. Pseudo-relevance feedback (PRF) techniques, which modify a query'srepresentation using the top-ranked documents, have been shown to overcome such inadequacies and improve retrieval effectiveness for both lexical methods (e.g., BM25) and dense methods (e.g., ANCE, ColBERT). For instance, the recent ColBERT-PRF approach heuristically chooses new embeddings to add to the query representation using the inverse document frequency (IDF) of the underlying tokens. However, this heuristic potentially ignores the valuable context encoded by the embeddings. In this work, we present a contrastive solution that learns to select the most useful embeddings for expansion. More specifically, a deep language model-based contrastive weighting model, called CWPRF, is trained to learn to discriminate between relevant and non-relevant documents for semantic search. Our experimental results show that our contrastive weighting model can aid to select useful expansion embeddings and outperform various baselines. In particular, CWPRF can improve nDCG@10 by upto to 4.1% compared to an existing PRF approach for ColBERT while maintaining its efficiency.


A mathematical model on the preparation process of polysilicic acid (PS) was established to joint the bench-scale study with industrialization.Poly-silicic-ferric (PSF) coagulant was prepared using PS as semi-manufactured goods.PS was prepared using water glass and H2SO4 solution,and mathematical modeling concerning the relationship between gelation time (t) and such factors as pH value,initial w (SiO2) and temperature was presented.The influence of pH value on the species of PS with certain polymerization degree was explored.PSF coagulant was prepared using PS,FeSO4·7H2O and NaClO3 by co-polymerization.Both coagulation performance in treating lower temperature and lower turbidity water by PSF and characteristics of PSF were investigated compared with those of polyferric sulfate (PFS) and poly ferric aluminum (PFA).Results show that some PS is depolymerized after decreasing pH value when PS reaches a certain degree of polymerization,but the species after depolymerization differs from that at the same original pH value.PSF has higher coagulation efficiency than PFS and PFA.The mathematical modeling on the preparation of PS is the basic condition for preparing high quality PSF in industrial scale.The particular characteristics of PSF are just the essential reason for its superior coagulation performance.In the coagulation mechanism of treating low temperature and low turbidity water by PSF,charge-neutralization/destabilization is the precondition and the bridging is the necessary condition.


The prediction of the influence of reservoir impoundment on water quality and phytoplankton community is the basis of ecological compensation or restoration. The aim of the current study was to predict the effects of reservoir impoundment on phytoplankton and shoreline vegetation communities using the space-time substitution method. The Huangjinxia Reservoir under construction on the Han River was selected as the research object. The space-time substitution method indicated that the average values of the total phosphorus (TP) and ammonia (NH4 þ-N) increased from 0.049 and 0.279 mg L 1 to 0.139 and 1.132 mg L , respectively, after reservoir impoundment. The percentage of diatom biomass exceeded 95% before the reservoir impoundment. However, it was gradually decreased to 75% after the reservoir impoundment. Meanwhile, the biomass of Chlorophyta, Cryptophyta and Pyrrophyta increased significantly, accounting for 32, 20 and 13% of the total biomass, respectively, after reservoir impoundment. Cynodon dactylon (65.3%), Polygonum hydropiper (51.7%) and Aster subulatus (50.3%) were the dominant shoreline vegetation before the reservoir impoundment, whereas after the reservoir impoundment, the dominant species shifted to Alternanthera philoxeroides (62.3%), Lobelia chinensis (55.7%) and C. dactylon (53.9%). Our results suggested that the percentage of bloom-forming phytoplankton would gradually increase after the reservoir impoundment. In addition, A. philoxeroides, C. dactylon and L. chinensis would be the plants suitable for living in the shoreline of reservoirs in this area.


The impact of foreign direct investment (FDI) on host country market concentration has been a controversial issue, both at the theoretical and the empirical levels. Most existing empirical studies point to a positive relationship, enhancing the negative effects of FDI on competition conditions, but there are also studies that support the argument that FDI reinforces competition. In this paper we analyze the impact of FDI on market concentration considering the Portuguese manufacturing industries in the period 2006-2009. Using panel data estimation we found a significant negative impact of FDI on industry concentration, which is in line with the results of other studies for developed countries, and gives support to arguments that FDI has positive effects on domestic firms, eventually through positive externalities.


The spread of misinformation has become a major concern to our society, and social media is one of its main culprits. Evidently, health misinformation related to vaccinations has slowed down global efforts to fight the COVID-19 pandemic. Studies have shown that fake news spreads substantially faster than real news on social media networks. One way to limit this fast dissemination is by assessing information sources in a semi-automatic way. To this end, we aim to identify users who are prone to spread fake news in Arabic Twitter. Such users play an important role in spreading misinformation and identifying them has the potential to control the spread. We construct an Arabic dataset on Twitter users, which consists of 1,546 users, of which 541 are prone to spread fake news (based on our definition). We use features extracted from users' recent tweets, e.g., linguistic, statistical, and profile features, to predict whether they are prone to spread fake news or not. To tackle the classification task, multiple learning models are employed and evaluated. Empirical results reveal promising detection performance, where an F1 score of 0.73 was achieved by the logistic regression model. Moreover, when tested on a benchmark English dataset, our approach has outperformed the current state-of-the-art for this task.


This paper discusses the impacts of urban expansion driven by real estate interests on the shape of the city. The rapid growth of urban sprawl in Brazilian cities, associated with the transformation of rural land into urban land, is a result of the power held by market agents (construction companies and contractors) over the urbanization process. In this context, we bring the example of Planaltina, a city located on the northern border of Brasilia and whose history is firmly intertwined with that of the federal capital. Founded in 1964, the city has been growing rapidly with legal and illegal settlements. We seek to understand the relationship between supply and demand for urbanized land in Planaltina, as well as the consequences of this way of expansion for the city in morphological terms. For that, an exploratory research was carried out, based on aerial images, urban projects and existing settlements, which allowed the comparison between the current situation and a projection of the future shape of the city. In addition, the Space Syntax Theory was applied in the elaboration of axial maps of the path networks observed at different times, aiming to reveal the existing connections, evaluating their permanence or finitude. The research uncovered the wide disparity between supply (large) and demand (small) for urban lots, as well as an urban fabric that, although fairly regular, is also excessively fragmented, as a result of the growth logic that has the main objective in profit, leaving the quality of space to the background.


THE CURRICULUMS OF THE FIRST CHEMISTRY COURSES AT UNIVERSITY OF COIMBRA AND BRAZILIAN UNIVERSITIES. The study of History of Education is very important to teacher education because it allows reflections and greater criticality about their own teaching practice and professional condition. The purpose of this research was to identify similarities between the curriculum of Chemistry courses of University of Coimbra (UC), National School of Chemistry (ENQ) and School of Engineering of Porto Alegre (EEPA) at the beginning of the 20th century seeking to identify possible influences of UC in the structuring and curriculum of the first Brazilian higher education Chemistry courses. The results showed more similarities regarding the structure between UC and ENQ, while there were greater correspondences in the curricular activities between UC and EEPA. Finally, it was not possible to identify confluences in the curriculums of the courses over the decades since there was a divergence between the models of organization of the higher education in the countries under study.


Equipment to enjoy a 3D image, such as a movie theater, television and so on have been developed many. So 3D video are widely known as a familiar image of technology now. The display representing the 3D image are there such as eyewear, naked-eye, the HMD-type, etc. They has been used for different applications and location. But have not been widely studied for the transparent 3D display. If transparent large 3D display is realized, it is useful to display 3D image overlaid on real scene in some applications such as road sign, shop window, screen in the conference room etc. As a previous study, to produce a transparent 3D display by using a special transparent screen and number of projectors is proposed. However, for smooth motion parallax, many projectors are required. In this paper, we propose a display that has transparency and large display area by time multiplexing projection image in time-division from one or small number of projectors to active screen. The active screen is composed of a number of vertically-long small rotate mirrors. It is possible to realize the stereoscopic viewing by changing the image of the projector in synchronism with the scanning of the beam.3D vision can be realized by light is scanned. Also, the display has transparency, because it is possible to see through the display when the mirror becomes perpendicular to the viewer. We confirmed the validity of the proposed method by using simulation.


Enhanced efficiency of heavy-duty truck powertrains with constraints imposed on noise, vibration, and harshness requires novel solutions for torsion vibrations attenuation. In the paper, the weight-vibration Pareto optimization problem for a novel vibration absorber, a triple mass flywheel, for application in heavy-duty truck powertrains is considered. Global sensitivity analysis and Pareto optimization method are used to design a novel vibration absorber. The optimization method attempts to minimize oscillations of the torque at the transmission input shaft as well as to minimize total mass inertia of the absorber. It is shown that there exists a Pareto front between the measure of the attenuation of oscillations of the torque and the total mass inertia of a triple mass flywheel. The optimized design parameters for the absorber are obtained that provide the best attenuation of oscillations of the torque at the transmission input shaft for different mean values of the engine driving torque. The analysis shows real evidence of the feasibility of the application of this concept of vibration absorbers in heavy-duty truck powertrains. It is also shown that optimized design parameters of a triple mass flywheel put this concept in a superior position in comparison with a dual mass flywheel.


We say that a unital C*-algrebra A has the approximate positive factorization property (APFP) if every element of A is a norm limit of products of positive elements of A. (There is also a definition for the nonunital case.) T. Quinn has recently shown that a unital AF algebra has the APFP if and only if it has no finite dimensional quotients. This paper is a more systematic investigation of C*-algebras with the APFP. We prove various properties of such algebras. For example: They have connected invertible group, trivial K_1, and stable rank 1. In the unital case, the K_0 group separates the tracial states. The APFP passes to matrix algebras. and if I is an ideal in A such that I and A/I have the APFP, then so does A. We also give some new examples of C*-algebras with the APFP, including type II_1 factors and infinite-dimensional simple unital direct limits with slow dimension growth, real rank zero, and trivial K_1 group. An infinite- dimensional simple unital direct limit with slow dimension growth and with the APFP must have real rank zero, but we also give examples of unital algebras with the APFP which do not have real rank zero.
Our analysis also leads to the introduction of a new concept of rank for a C*-algebra that may be of interest in the future.


Two balances, one for measurement of ferromagnetic magnetization, the other for paramagnetic susceptibility measurements, are described. Designs are based on Sucksmith's ring balance but the ring and optical lever system of the latter has been replaced by a strain gauge bridge which allows the force on the magnetic specimens to be determined via potentiometer readings. The modified balances are very robust, insensitive to vibration and, if desired, suitable for direct recording. Relative accuracies to 0.3% and 0.5% are obtained respectively for the ferromagnetic and paramagnetic systems.


Providing an apparatus for manufacturing a toroidal coil which can be mechanically wound windings. A first clamp 3 for securing the remainder 45B of the winding 45, is fixed to the vicinity of the other end of the winding is passed through the annular core 46, a movable clamp 27 for rotating the other end of the winding, an annular core including fixed, the core clamp mechanism 30 moves in the horizontal direction, a second clamp 20 for fixing the other end of the winding when the other end of the winding projecting from the movable clamp passes through the annular core is inverted and to rotate the other end of the winding in the movable clamp, by separating close or rotary clamp or second clamp an annular core, winding the windings on the annular core.


diagnosis of acute appendicitis. When he was first seen at our hospital, the right lower quadrant pain was already relieved and there were no findings suggestive of perforation. We thus selected conservative therapy with antibiotics and he was admitted to our hospital. However, on the 2 nd hospital day, he had recurred and aggravated right lower quadrant pain, so that emergency laparoscopic operation was performed. The surgical findings included an appendix which changed in color to dark violet, absence of perforation, and no pus adhesions to the surroundings. It was confirmed that severe ischemic change had been caused by torsion of the appendix at the root. We thus reduced the torsion and performed appendectomy. Since we successfully conducted appendectomy before appendiceal perforation due to the torsion, his postoperative course was uneventful and he was dis-charged from our hospital on the 4 th postoperative day. We report a case of torsion of the vermiform appendix in which laparoscopic operation for diagnosis and treatment was useful, with some bibliographic comments.


This study is aiming to separate highway entrance ramps from impact zones which are considered the characteristics and real traffic situations in each lane and section. The results of this study can be applied to Lane Control System and control the traffic flow for highway more efficiently. Based on earlier studies which analyzed impact zones in entrance-ramp junction using the standard deviation of speed, this study divides more segmentalized impact zones according to the degree of turbulences. As a result of this study, about 800m of intervals, from 500m of upper flow (1,2,3 lane) to 300m of lower flow(2, 3 lane), shows similar traffic characteristics influenced by entrance ramp directly.


Machine learning (ML) techniques have been used around the world to solve different problems. In this work, we applied ML techniques to estimate lightning distance for return strokes (RS) in negative cloud-to-ground (-CG) flashes. The approach uses E-field records from a single-station system. A lightning electric field waveform dataset containing more than 1500 waveforms of negative RS recorded at LOG, Florida, US was used to train and validate the ML classifiers. The dataset was split into day time and night time records. For day-time records, the quadratic Support Vector Machine (SVM) classifier was the one with the best accuracy (80%) and for night-time, the best one was the linear SVM with an accuracy of 88%. The ML classifiers were applied to estimate lightning distance in thunderstorms in the Amazon region of Brazil, and the results were compared against GOES-16 images and STARNET lightning location data. The main application of such methodology is for regions with no lightning location systems or no communication links to obtain lightning location data.


The formation of vein patterns in leaves has captivated biologists, mathematicians, and philosophers. In leaf development, files of vein-forming procambial cells emerge from within a seemingly homogeneous subepidermal tissue through the selection of anatomically inconspicuous preprocambial cells. Although the molecular details underlying the orderly formation of veins in the leaf remain elusive, gradually restricted transport paths of the plant signaling molecule auxin have long been implicated in defining sites of vein differentiation. Several recent advances converge to more precisely define the role of auxin flow at successive stages of vascular development. The picture that emerges is that of vein formation as a self-organizing, reiterative, auxin-transport-dependent process.


Welcome to issue 19 of Research Notes, our quarterly publication reporting on matters relating to research, test development and validation within Cambridge ESOL. The theme of this issue is the development and validation of new assessment products and the opportunities for collaboration these bring. We report on products under development which take Cambridge ESOL for the first time into primary, secondary, tertiary and higher education sectors in the UK with multilingual tests within the Asset Languages project; into the Adult ESOL curriculum with Skills for Life tests, as well as reporting on the development of the Teaching Knowledge Test, which will assess teachers' professional knowledge about the teaching of English to speakers of other languages in a worldwide context. This issue also focuses on developing frameworks for describing and introduce Asset Languages, an assessment system being developed by UCLES to implement the Languages Ladder, a voluntary recognition system in the UK which seeks to give people credit for their language skills across 26 languages. Next, Mick Ashton and Hanan Khalifa outline the Teaching Knowledge Test (TKT), an award for teachers of English at any stage in their career which was developed in response to stakeholder needs. Tony Green then reports on an impact study which is tracking the career paths of people who have taken our Certificate in English Language Teaching for Adults (CELTA). James Simpson describes a collaborative project with researchers at Leeds and London Universities which is developing an instrument for assessing speaking of adult ESOL learners in the UK. This project has informed the development of our ESOL Skills for Life awards which will be available from April 2005. Continuing the theme of collaborative activities, Lynda Taylor outlines how Cambridge ESOL has forged closer links with other departments in the University of Cambridge which is followed by a review of former head of the University's Research Centre for English and Applied Linguistics Gillian Brown's recent staff seminar on applied linguistics and second language listening. The final two articles deal with frameworks and comparability issues between language tests. Neil Jones describes how tests for 26 different languages are being related to the Languages Ladder framework, focusing on how objectively marked components (reading and listening) can be linked to it. Turning to writing, Roger Hawkey and Stuart Shaw draw implications from developing a common descriptive scale for assessing writing to comparing Main Suite, IELTS and BEC writing scripts and …


Treatment methods for concrete road surface cracks, angle of rupture and so on with modified epoxy resin pouring craft are discussed in this paper. And the characteristic and pouring construction craft of modified epoxy resin are introduced. In addition to it, pouring effect is also analyzed.


We study the ``lepton-specific'' two Higgs doublet model, in which one doublet ${\ensuremath{\Phi}}_{\ensuremath{\ell}}$ gives mass to charged leptons and the other ${\ensuremath{\Phi}}_{q}$ gives mass to both up- and down-type quarks. We examine the existing experimental constraints on the charged Higgs boson mass and the parameter $\mathrm{tan}\ensuremath{\beta}\ensuremath{\equiv}⟨{\ensuremath{\Phi}}_{q}^{0}⟩/⟨{\ensuremath{\Phi}}_{\ensuremath{\ell}}^{0}⟩$. The most stringent constraints come from LEP-II direct searches and lepton flavor universality in $\ensuremath{\tau}$ decays. The former yields ${M}_{{H}^{\ifmmode\pm\else\textpm\fi{}}}\ensuremath{\ge}92.0\text{ }\text{ }\mathrm{GeV}$; the latter yields two allowed regions $0.61\mathrm{tan}\ensuremath{\beta}\text{ }\text{ }\mathrm{GeV}\ensuremath{\le}{M}_{{H}^{\ifmmode\pm\else\textpm\fi{}}}\ensuremath{\le}0.73\mathrm{tan}\ensuremath{\beta}\text{ }\text{ }\mathrm{GeV}$ or ${M}_{{H}^{\ifmmode\pm\else\textpm\fi{}}}\ensuremath{\ge}1.4\mathrm{tan}\ensuremath{\beta}\text{ }\text{ }\mathrm{GeV}$, and excludes parameter regions beyond the LEP-II bound for $\mathrm{tan}\ensuremath{\beta}\ensuremath{\gtrsim}65$. We present the charged Higgs decay branching fractions and discuss prospects for charged Higgs discovery at the LHC in this model.