Based on the unprecedented clinical efficacy of PD-1/PD-L1 pathway checkpoint inhibitors (CPI), non-redundant immune checkpoints like TIM-3, LAG-3, TIGIT or BTLA are currently being targeted, by combinatorial approaches using monospecific or bispecific antibodies. Up-regulation of TIM-3 has been described as an adaptive CPI resistance mechanism, and internal prevalence data on archival samples of CPI-naive and -experienced patients showed co-expression of PD-1 and TIM-3 in various tumor types, consistent with literature reports. Here, we describe RG7769 (PD1-TIM3), a novel avidity driven heterodimeric PD-1/TIM-3 1+1 bispecific CrossMabVH-VL intentionally designed as high affinity PD-1 (KD 250 pM, 37°C) and low affinity TIM-3 (KD 130 nM, 37°C) Fab-moieties to specifically target PD-1+ and PD-1+ TIM-3+ T cells through avidity gain, while bypassing PD-1- TIM3+ myeloid and NK cells. In contrast to IgG4-based PD-1 antibodies and conventional IgG1-based TIM-3 Fc-effector function competent antibodies, RG7769 harbors a PG LALA containing heterodimeric KiH IgG1 Fc-region rendering the BsAb refractory to drug shaving by FcgR-expressing macrophages in the TME, while retaining IgG-pharmacokinetics. RG7769 binds to PD-1 with higher affinity than pembrolizumab and nivolumab. X-ray crystallography demonstrated that the humanized PD-1 binding Fab recognizes a unique glycosylated epitope on PD-1, and potently blocks the PD-1/PD-L1 and PD-1/PD-L2 interactions in both biochemical and reporter cell line assays. The humanized TIM-3 binding arm was identified for maximal functional activity using mixed lymphocyte reaction (MLR) assays. Compared with bivalent TIM-3 antibodies, RG7769 shows reduced binding to TIM-3+ myeloid and NK cells, but binds preferentially to dysfunctional T cells expressing PD-1 or both PD-1 and TIM-3, like tumor infiltrating lymphocytes (TILs) in the tumor microenvironment. By virtue of its monovalency, RG7769 induced low antibody internalization on activated T cells when compared with bivalent TIM-3 antibodies, overcoming a major cellular sink for TIM-3 antibodies. In functional assays, RG7769 showed increased IFN-γ secretion by in vitro generated tumor-specific T-cells, increased ex vivo tumor-specific effector functions of T cells from PBMCs of melanoma patients, and enhanced the anti-tumor-activity of TILs from melanoma patients when compared to the monospecific parental PD-1 antibody. Finally, RG7769 showed superior efficacy in controlling s.c. MC38 tumor growth in huPD-1/huTIM-3 transgenic C57/BL6 mice compared to the parental PD-1 antibody. In summary, these preclinical data support the use of RG7769 as a monotherapy and as combination partner for the treatment of patients with solid/hematological tumors. A phase I study is currently ongoing in patients with advanced metastatic solid tumors (NCT03708328). Citation Format: Laura Laura Codarri Deak, Stefan Seeber, Mario Perro, Patrick Weber, Laura Lauener, Standford Chen, Sonja Offner, Stefan Dengl, Friederike Hesse, Adrian Zwick, Marco Boettger, Alexander Bujotzek, Jorg Benz, Guy Georges, Georg Fertig, Valeria Lifke, Jens Fischer, Stephane Leclair, Victor Levitsky, Marta Canamero, Juha Lindner, Sara Colombetti, Stefanie Bendels, Christophe Boetsch, Matthias Fueth, Merlind Muecke, Henry Kao, Pablo Umana, Christian Klein. RG7769 (PD1-TIM3), a novel heterodimeric avidity-driven T cell specific PD-1/TIM-3 bispecific antibody lacking Fc-mediated effector functions for dual checkpoint inhibition to reactivate dysfunctional T cells [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2270.


Copyright © 2018 by Journal of Korean Academy of Oral Health This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives: The present study aimed at investigating the potential of using 18b-glycyrrhetinic acid against the cariogenic characteristics of Streptococcus mutans UA159. Methods: The effects of 18b-glycyrrhetinic acid on biofilm formation and acid production were evaluated; the latter are indicators of cariogenicity of S. mutans. Biofilm architecture was also analyzed by scanning electron microscopy (SEM), and changes in gene expression related to biofilm formation were studied by quantitative RT-PCR. Results: Treatment with 18b-glycyrrhetinic acid at a concentration of 20 mg/ml inhibited biofilm formation by 95% in the absence of sucrose and 60% in its presence, reduced acid production by 88.8%, and significantly suppressed the gene expression of comDE, gbpB, gtfC and vicR, which are thought to be involved in the virulence of S. mutans. Conclusions: These results suggest that 18b-glycyrrhetinic acid could be used as a complementary or alternative agent for preventing dental caries by interfering with the virulence properties of S. mutans without affecting the viability of the bacterial population.


My purpose in The Limits of Integrative Bargaining was to bring a measure of clarity and discipline to the then-current discussion of integrative bargaining. Specifically, I sought to:
 1. clarify the meanings of value creation and integrative bargaining so that the terms could be better put to use in the study, teaching, and practice of negotiations;...


Introduction: Abnormal uterine bleeding is a broad term that describes irregularities in the menstrual cycle involving frequency, regularity, duration, and flow volume outside pregnancy. The symptoms of Asrigdara, which are expatiated in Ayurveda, are closely similar to that of abnormal uterine bleeding. The approach mode through oral treatment acts as aamapachaka, vatapitta shamaka, agnivardhak, stambhaka, and soolahara. So Ashokarishta, Chandraprabha vati, Avipatikara churna, and Sukumara ghrita were selected to manage the Asrigdara. Method: This is a single case study of a 38-year-old female patient who came with the complaint of increased duration of periods of more than ten days with heavy bleeding and the reduced interval between periods from 2 months. In this case study, palliative management was done with oral Ayurvedic formulations. The main aim of the treatment was to minimize cyclic blood loss with regularization of the cycle and to improve the patient's general condition. Result: There was a reduction in bleeding and duration of menstrual flow without clots, and the patient remained entirely asymptomatic on observation during follow-ups.


We investigate regular central structures in multiply connected, anti\char21{}de Sitter spacetimes with spherical, planar and hyperbolic geometries. We obtain an exact solution for the pressure in terms of the radius when the density is constant. We find that, apart from the usual simply connected spherically symmetric star with a well-behaved metric at $r=0,$ the only solutions with non-singular pressure and density have a wormhole topology. However these wormhole solutions must be composed of matter which violates the weak energy condition. Admitting this type of matter, we obtain a structure which is maintained via a balance between its cohesive tension and its repulsive negative matter density. If the tension is insufficiently large, this structure can collapse to a black hole of negative mass.


Manuscript received: 03.05.17; Revision accepted: 08.08.17 We describe the evolution of subinternal limiting membrane (ILM) hemorrhage associated with anemic retinopathy on fundus autofluorescence (FAF) and spectral domain optical coherence tomography (OCT). A 27-year-old male with megaloblastic anemia complained of defective vision in the right eye (RE). Fundus examination revealed multiple Roth spots bilaterally suggestive of anemic retinopathy. Preretinal hemorrhage was seen over the fovea and temporally in the RE which appeared hypoautofluorescent on FAF and as hyperreflective echoes beneath an elevated ILM on OCT. Hemorrhages resolved following treatment with blood transfusion, folate, and Vitamin B12 supplements. Sub-ILM hemorrhage transformed into a yellow spot at macula which was hyperautofluorescent on FAF and hyperreflective on OCT and then resolved leaving a small sub-ILM hyporeflective cavity. Recent sub-ILM hemorrhage is hypoautofluorescent as fresh blood has no autofluorescence while altered blood is hyperautofluorescent due to bilirubin in the degraded heme which is an endogenous fluorophore.


It is considered that land deformation caused by open-cut mining influences wind shift around the quarry. The authors made a statistical study on the influence of topography on the wind speeds at 8 meteorological stations in Iwate Prefecture. It was recognized that the wind speeds at meteorological stations in the mountainous district were affected by the surrounding topography in sprig and fall. It was investigated the correlation between the mean wind speeds and the deviations of inclination. It was concluded that the topography within 1km-radius affected the wind speeds. It was obtained the next quantitative formulae between the mean wind speeds (Vs, Vf: m/s) and the deviations of inclination in the same directions (Ki).Vs=-6.15Ki+3.03 (in sprig)Vf=-5.16Ki+2.59 (in fall)The deviations of inclination Ki are defined as follows.Ki=tan αi-16Σj=1tan αj/16 (i=1, 2, ......, 16)Where tan αi=ΔHi/LiHere, ΔHi is the difference between the altitude of the base point and the highest point within 1km-radius.Li is the distance from the base point to the highest point.It became possible to predict the change of mean wind speed around the quarry by the use of these formulae. As a case study was conducted at the quarry that made a plan to be mined-out the whole mountain. As a result, it was predicted that wind system around the quarry would change widely with land deformation caused by open-cut mining.


This paper draws on preliminary data from an ongoing project implemented by TASO Uganda and Population Council, which aims to contribute to promotion of the sexual and reproductive health (SRH) rights of young people aged 10-19 years perinatally infected with HIV. The key argument in this paper is that HIV/AIDS programming in Uganda and elsewhere in Africa will need to acknowledge that the population of young people perinatally infected with HIV is growing and to specifically target them. HIV/AIDS programming will also address the sexuality dreams and desires of young people perinatally infected with HIV by providing them with information and practical support to understand their sexuality as they grow. This information is critical to guide them to negotiate vital aspects of their sexuality, enjoy positive lifestyles, and avoid undesired consequences such as unwanted pregnancies, infection of others and self re-infection. Effective sexuality counseling should also be provided so that young people living with HIV can make informed choices and be able to balance responsibility with sexuality desires.


Conflict and collaboration are two forms of the relationship between universities and communities. This article makes an in-depth study on the conflicts and collaborations between American universities and communities. The research focuses on the following aspects:housing,traffic and parking,environment and public education. In the last part,the article reflects the reasons rationally,which will provide some useful suggestions for the relationship between Chinese universities and communities.


If a coastal State claims a continental shelf beyond 200 nautical miles (nm) that intrudes into the 200-nm limit of another State, the problem arises as to whether there is a hierarchical relationship between natural prolongation and distance, the two criteria of entitlement to the continental shelf provided by Article 76 of the UN Convention on the Law of the Sea. A positive answer would mean that the continental shelf beyond 200 nm cannot encroach upon the 200-nm limit, otherwise there would be an area of overlapping entitlements which calls for maritime delimitation. This article attempts to analyse this problem from the perspectives of Article 76, relevant judicial cases, State practice, and the relationship between the regimes of the continental shelf and the Exclusive Economic Zone. It is submitted that the law is not conclusive, though a majority of coastal States tend to adopt a self-constraint approach. In addition, this problem brings further challenges to the law of maritime delimitation.


Instrumental time series are often affected by inhomogeneities which can mask or amplify climate change signals. Various procedures for the detection and adjustment of breaks exist for monthly and annual time series. Homogenization methods on a daily basis are scarce and often disregard uncertainties accompanying the break adjustment. We present a complete homogenization procedure for daily extreme temperature series based on the break detection method PRODIGE and SPLIDHOM for break correction. Both parts of the homogenization rely on the existence of highly correlated reference stations. After the statistical comparison with neighbouring stations, detected breaks are verified and further localized by metadata. Uncertainties of the break adjustments are estimated by altering reference stations and by applying a bootstrapping technique providing an objective indication about the reliability of the homogenization.


Keratoconjunctivitis in sheep causes severe ocular irritation thereby reducing the production performance thus causing economic loss to the farmers. Bacterial cause of keratoconjunctivitis in sheep may be due to Listeria monocytogenes, Moraxella ovis, Mycoplasma conjunctivae, etc. An investigation carried out at Tirupathur, Sivagangai district, Tamil Nadu, India revealed keratoconjunctivitis in sheep (population 100 animals). Isolation and identification of eye swabs from ailing animals (n = 5) showed that the bacteria was Moraxella sp. Polymerase chain reaction (PCR) of the isolate was positive for Moraxella sp. Antimicrobial sensitivity testing of the isolate showed that it was sensitive to all antibiotics used in the study. This study reports the presence of Moraxella sp. infection in sheep warranting further studies to know the exact status of this organism so as to prevent keratoconjunctivitis in sheep.


in summer 1938, planned forced emigration and deportation, while the Gestapo controlled the Jewish community, punished individual Jews, issued anti-Jewish regulations, and organized the looting of assets in Vienna (365). For the mass deportations of Austrian Jews to the occupied East, the authors emphasize that Eichmann's Central Office acted in close cooperation with the Vienna Gestapo. The Gestapo arrested many escaped Jews and non-Jewish Austrians who helped them. They also organized the expropriation of Jewish belongings by creating unique offices for this purpose. In March 1945, Karl Ebner reported to Himmler assets of one billion Reichsmarks for the Nazi State (201). Challenging previous scholarly assumptions about Nazi society, the authors emphasize that the Vienna Gestapo did not depend on denunciations for their fight against "enemies," except for public protest and so-called radio and economic crimes during the war. Illustrated by short case studies, the authors describe Gestapo actions against Catholicism in Austria, including the seizure of property and writings; the persecution of Freemasons; and the even harsher crackdown on Jehovah's Witnesses. With the help of a huge system of turncoat informants from the resistance milieu, often produced by centrally legalized torture, the Gestapo dismantled resistance groups of all political colors. The repression of communist resistance could be called their greatest success, according to the authors. In 1943/44, after most organized resistance was squashed, 77 percent of all Gestapo arrests targeted foreign forced laborers and Soviet POWs, whose resistance is still under-researched. As in Germany, Austrian perpetrators rarely received severe punishments after the war. Although many went to trial, they often got away with short sentences—not for their actual crimes but for being illegal Nazi Party members before the annexation. When the Gestapo head Huber claimed that he had helped Jews, the allies released him with a small fine and one year of probation. Supposedly, he had executed his tasks "as fairly and reasonable as possible" and was not a supporter of Nazi ideology (106). Some officers received more severe prison sentences but were released early. Overall, the book provides an overview of the establishment, activities, and aftermath of this largest regional Gestapo office, and it contains a useful bibliography. Unfortunately, excessive subtitles and the repetition of facts hinder the flow of the text. Comparisons with available German Gestapo studies, for example on Düsseldorf, could have helped this work, which often provides more description than analysis. There are some mistakes, such as the suggestion that the Reich Security Main Office existed during the time of the annexation, though it was founded only in September 1939 (63). At times, available literature on Austria could have prevented errors, such as the assertion that since summer 1939 Jews were recruited for minimal paid forced labor (184); the program was born in Vienna and introduced in the fall of 1938. Finally, it should be mentioned that Eichmann's Central Office and the Gestapo were not solely responsible for anti-Jewish policy in Austria: there were various actors initiating discriminatory policies including municipalities, the Nazi Party, and Austrian ministries.


Findings of a study that examined the nature of moral and ethical conflict and accommodation within the schools are presented in this paper, which introduces the conceptual framework of a larger empirical study in progress. The study attempted to: (1) describe the ethical conflict and moral dilemmas faced by teachers and principals; and (2) investigate individuals' actions and beliefs to determine whether an awareness of personal value issues exists. Interviews were conducted with a total of 30 respondents: 5 elementary and 5 secondary principals, and 10 elementary and 10 secondary teachers. Findings indicate that for teachers, professional, collegial loyalty was a dominant measure of moral/ethical action. A conclusion is that individual moral codes often conflict with the entrenched ethical dimensions of the school culture and that conflicts and implicitly valuational resolutions can be expected. (75 references) (LMI) ************It*************************************A******************IOS * Reproductions supplied by EDRS are the best that can be made * * from the original document. *


Administration aims for effective guarantee of administration caused by the modern administration which has an increase in quantity of administrative...


Complement activation is associated with a variety of inflammatory conditions including atherosclerosis, but the mechanism of complement activation in these settings is poorly understood. Endothelial cells (EC) play an important role in vascular pathology and express a variety of complement receptors, including gC1qR/p33, recognizing the globular domain of the complement component C1q. In preliminary studies, purified recombinant gC1qR/p33 was found to support C1q-dependent C4 activation in vitro, comprising 19.5% ± 8.3% (mean ± S.D., n=5) of that produced by aggregated IgG. In contrast, a truncated form of gC1qR/p33, lacking the C1q binding domain, failed to support C4 activation. Additional studies were performed with immortalized bone marrow microvascular EC to investigate classical complement pathway activation and deposition. EC were exposed to anticoagulated (0.32 % sodium citrate) human plasma, diluted (1/10) in 0.01 M HEPES buffered modified Tyrode's solution, pH 7.5, containing 2 mM Mg Cl2 and 1 mM CaCl2, for 60 min, 37°C. A solid phase ELISA approach was used to detect EC-associated C1q and C4 activation (C4d). Statistically significant deposition of C4d (0.72 ± 0.3. OD units (ODU), n=4)(p=0.04) and C1q (0.57 ± 0.19. ODU, n=4) (p=0.002) was observed on EC that had been immobilized on poly-L-lysine coated microtiter wells. Consistent with classical complement pathway activation, C4d deposition remained at baseline (0.23 ± 0.13, ODU, n=4) in the presence of 10 mM EDTA, but C1q deposition was unaffected. Moreover, no significant C1q or C4d deposition occurred when endothelial cells were exposed to C1q depleted serum. Similar studies were performed using EC grown to confluence on Type I collagen to examine the effect of shear stress (12 dynes/cm2 for 1 hour in a cone-and-plate shearing device), simulating flow conditions in coronary arteries, on classical complement pathway activation and deposition. Compared to static conditions, shear stress resulted in an approximately 50% increase in C1q and C4d deposition on EC. This was accompanied by an approximately 2-fold increase in EC binding of a monoclonal antibody, 60.11, recognizing the N-terminal C1q binding domain of gC1qR/p33. Taken together, these data present evidence for a potential paradigm shift, illustrating immune complex independent classical complement pathway activation by gC1qR/p33, and deposition of activated classical complement components on EC. The generation and deposition of active complement components on EC is likely to contribute directly to vascular inflammation and atherosclerotic changes.


In the years 1955–56, when it had already become evident that the star of the Stalinist Rákosi-Gerö clique was on the wane in Hungary, Ho Te-ch'ing was the Chinese Ambassador in Budapest. It soon became apparent that he was quietly establishing connexions with the opposition. Not only did he have free access to the highest Party circles and maintained regular contact with the Foreign Ministry (as could be expected of a Party and state representative) but the Chinese Embassy sponsored an extensive intelligence apparatus and was generally regarded as the best informed foreign post in the Hungarian capital. The Cultural Attaché, who spoke Hungarian fluently, maintained contact with Hungarian intellectuals. At the same time, correspondents of the New China News Agency and the Chinese exchange students in Budapest reported to the Ambassador on the activities of the revolutionary Petöfi Circle and the universities. The Ambassador himself travelled widely in the country, becoming acquainted with the local Party secretaries, councilmen and other leaders in the towns and villages. He was also prominent in the social life of the Hungarian capital; his two cooks and staff providing a lavish Oriental touch. While the Soviet Embassy invited Hungarian Stakhanovists (elite workers) to its receptions, Ho was more interested in entertaining leading writers, artists, economists and newspapermen, even those who were not outspoken supporters of the regime.


An adaptive beamforming algorithm based on undesired disturbance cancellation and steering vector constraint is proposed to solve the problem of beamforming performance degradation caused by formation distortion and array model mismatch during passive sonar operation. This algorithm reconstructs interference-plus-noise covariance matrix (INCM), which is closer to the real value through the uncertainty set constraint of the steering vector, discusses the composition and estimation method of the undesired disturbance of Capon power spectrum, and gives the basic implementation flow of the covariance matrix reconstruction algorithm. The robustness of the algorithm is verified by simulation results.


Interrogation of suspects in the investigation stage, though an important means to collect evidences, is restricted by protection of human rights. While choosing the methods of interrogation, we have to avoid the conflict between human rights protection and truth finding. The legitimacy of interrogation lies in a suspects' voluntary confession. However, an entirely voluntary confession does not necessarily mean that the interrogation is legitimate. In consideration of both the protection of human rights and the efficiency of criminal investigation, we must ensure that no one is self-incriminated while urging suspects to admit the truth. Furthermore, interrogation methods that might slightly infringe voluntary confessions might be permitted.


Mutations in the X‐linked MECP2 gene cause Rett syndrome, a neurodevelopmental disorder that exclusively affects girls. Females with the MECP2 mutations exhibit a broad spectrum of clinical presentations ranging from classical Rett syndrome to asymptomatic carriers, which can be explained by differences in X chromosome inactivation (XCI). Here, we report a family with a girl with Rett syndrome in whom a novel missense mutation in the MECP2 gene was transmitted through the maternal germ line. The carrier mother was asymptomatic and presented non‐random XCI in the peripheral blood cells, which resulted in the X chromosome harboring the mutant allele that was predominantly active. Thus, the presence of non‐random XCI in the peripheral blood cells did not provide an explanation for the normal phenotype of the carrier mother. This result suggests that mechanisms other than XCI may contribute to the phenotypic heterogeneity associated with MECP2 mutations.


Interest in minimal-incision total knee arthroplasty (TKA) has increased in recent years. The advantages of minimally invasive techniques (MIS) used for TKA are faster functional recovery, shorter hospital stay and better early knee range of motion. It is known that the long-term outcome after TKA is related to component position and ligament balance. The smaller incision in MIS might be associated with increased risk of malalignment of components due to limited visualisation. Malalignment of implants in TKA has been associated with implant failure and poor long-term functional results. There is a lack of evidence in the literature that MIS can achieve the same results as the standard TKR approach in terms of component alignment precision. Seventy patients scheduled for a primary TKA were prospectively evaluated postoperatively with coronal and sagittal radiographic long limb films. Mini-midvastus approach was used for all TKA. There were no complications and the radiographic evaluation found no implant o...


The theme for this article is dynamic and innovative research environments and the factors that characterise them. The focus is on the relationship between the organisation and management of research, research processes and environmental conditions on the one hand, and research quality and outcomes on the other. The article takes as a point of departure the results of an empirical study of 15 university and other public-sector research environments in Denmark. It identifies the features that characterise the framework of research, research processes, the working and social milieu of research environments and their influence on research in a smaller European country from a research-policy perspective. Innovative research environments could serve as references for research agents attempting to promote innovation and further develop a dynamic science base. Copyright , Beech Tree Publishing.


rather stilted, limited and disjointed, but it is followed by a further surprise in the form of a chapter on the social and cultural setting for conservation in Arabia. It is crucial to comprehend the Islamic perspective, for 'the role of the foreign conservationist in Arabia is essentially that of a short-term guest, contributing experience from elsewhere towards a uniquely Arabian and Muslim enterprise.' Maybe more Western conservationists should attempt to understand fully the local cultural norms before implanting their ideas elsewhere in the world.


Thermal energy storage for space cooling is a load management technology that achieves load shifting by creating and storing cooling capacity during off-peak hours in anticipation of peak period loading. The charge and discharge process in a cool energy storage system is typically a 24-hour cycle. In this paper, an optimal controller for this process is designed that minimizes the operating costs of the storage facility. A 24-hour load-forecast model is developed to achieve dynamic system response to the variations in the ambient weather conditions. Hourly building cooling loads are predicted over the 24-hour horizon to schedule adequate charging of storage to meet peak-period loads. The degradation of performance of the optimal control algorithm attributable to the lack of perfect foresight of weather conditions and associated building loads is analyzed via a case study. A safety margin is also calculated and presented to compensate for same. >


In order to explore the spectral energy distribution of various objects in a multidimensional parameter space, the multiwavelenghth data of quasars, BL Lacs, active galaxies, stars and normal galaxies are obtained by positional cross-identification, which are from optical(USNO A-2), X-ray(ROSAT), infrared(2MASS) bands. Different classes of X-ray emitters populate distinct regions of a multidimensional parameter space. In this paper, an automatic classification technique called Support Vector Machines(SVMs) is put forward to classify them using 7 parameters and 10 parameters. Finally the results show SVMs is an effective method to separate AGNs from stars and normal galaxies with data from optical, X-ray bands and with data from optical, X-ray, infrared bands. Furthermore, we conclude that to classify objects is influenced not only by the method, but also by the chosen wavelengths. Moreover it is evident that the more wavelengths we choose, the higher the accuracy is.


One of characteristic features of a volleyball game is playing consecutive sets and deciding the current score according to the results of particular sets. In this way we can examine volleyball game in many stages, but the results of a game are fixed in the third, fourth or fifth stage. Each set creates a temporary state, which occurs with definite probability. It is immediately dependent on accepted foundations of probability of winning a set in every game stage. In the research we analysed a simplified model. For the needs of this model we draw a tree figure, which describes states of passing sets in a volleyball game. We described also a theoretical model and illustrated its helpfulness for interpretation of the results of female I-league from the starting season 1998/1999 for the team Augusto Kalisz, the winner of principle season.


Collection of Mysteries;written by Niu Sengru,is well-known as the representative of the legendary work collections in Tang Dynasty. Compared with former works,either mysterious novels in the Six Dynasties,or the individual and collective works of legend in early Tang Dynasty,the author made a meticulous exploration in art,shaped his own literary style and thus achieved a high accomplishment which was mainly indicated as following:the writer was more aware of being creative and reinforced the portrayal of the character's personality in the plot;he was good at constructing the mood of a poetic sense of beauty;the stories were narrated in the way of stimulating dialogues between roles and dividing the arrangement of ideas;the work had also reflected his aesthetic pursuit of focusing on the history.


In 15 patients with atrial fibrillation under digitalis treatment a pseudonormalisation of the ST-T downward arch was observed. This phenomenon takes place after a short and definite interval following the preceding QRS complex and may be considered as a supernormal repolarisation phenomenon.


When designing a reinforced concrete column, most codes of practice specify that second order effects must be taken into account when the column slenderness exceeds a lower limit, usually associated to a certain loss of column carrying capacity. Such lower slenderness limits depend on the strength, stiffness, boundary conditions, and forces acting on the column. In this paper, simplified analytical expressions are presented for the lower slenderness limit of symmetrically reinforced rectangular columns. The limits, associ- ated with a chosen (5 and 10%) loss of bearing capacity compared to nonslender columns, are derived based on general mechanics of concrete structures. The proposed formulae take into account the most important parameters governing the behavior of slender concrete columns, such as axial load, first order end eccentricities, ratio between permanent and total load, creep coefficient, amount and distri- bution of the reinforcement, and also different loading paths. Similar limits can readily be derived for section shapes other than the rectangular shape considered here. The results of the proposed formulae fit very well with those obtained by a nonlinear and time dependent analysis model previously developed and checked.


For Finding Financial Performance and analysis of PACCS to Review the present status of PACCS of Salem District inTamilnaduState, Find out the Financial Performance and Analysis of PACCS for the period of 10 years from 2005-06 to 2014-15 as per the available Audit Accounts. The suggestion appropriate measures to improve the profit and service of PACCS based on the Findings of the present study.  The present paper attempts to explore the relationship between PACCS selected study for Financial performance and analysis.  The PACCS are placed under three categories viz. viable, potentially viable, and unviable.


This paper introduces the designing and realizing method of an applied evaluating system for architectural bidding and bid invitation,especially the realization of technical evaluation based on network technology.The system breaks through traditional public bid-inviting model and realizes computer management in the process of bid invitation.Through the use of such a system,all the evaluating experts can grade at real time,and the system can count at the same time.In this way,the impartiality and reliability of statistics can be ensured.Therefore,the system can be well regarded as the perfect combination of bidding concepts and network technology.


Dogs produce fewer sperm than other species. Furthermore, for French Bulldogs, anatomical peculiarities, low libido, and increased sensitivity to stress could cause further reductions in sperm count. The objective was to compare effects of semen collection at 24- versus 48-h intervals on semen quality of French Bulldogs. Five purebred French Bulldogs, 19 to 48 months old, were subjected to 5 semen collections (24 h apart). After a 30-day rest, collections were repeated, but the interval between collections was 48 h. Semen was collected (all 3 fractions) by digital manipulation without female stimuli. Volume was measured in a 20-mL syringe. Sperm concentration was determined with a Neubauer counting chamber. Motility and vigor were evaluated with a coverslipped drop of semen on a slide (preheated to 37°C). Motility was expressed as a percentage of motile sperm, and vigor was classified on a scale of 1 to 5. Morphology was evaluated by the panoptic method; 100 cells were counted and results expressed as the percentage of normal or defective cells. Effects of collection interval were analysed using PROC MIXED of SAS (animal as subject and collection as a repeated measure), with collections 2 to 5 compared with collection 1 (using the DIFF option). For collection every 24 h, the third, fourth, and fifth sperm collections were lower than the first collection for volume (10.4 ± 1.1, 8.3 ± 1.1, 5.6 ± 1.1, 3.5 ± 1.1, 2.4 ± 1.1 mL), concentration (437 ± 24, 448 ± 24, 370 ± 24, 322 ± 27, 258 ± 31 ×106 sperm mL–1), vigor (4.6 ± 0.2, 4.2 ± 0.2, 3.6 ± 0.2, 3.7 ± 0.2, 3 ± 0.2), and morphologically normal sperm (82 ± 2.2, 83 ± 2.2, 72 ± 2.2, 68 ± 2.5, 66 ± 2.9%). However, when the interval was increased to 48 h, only the fourth and fifth collections were lower (P < 0.05) than the first for volume (11.8 ± 1.1, 10.2 ± 1.1, 8.8 ± 1.1, 6.6 ± 1.1, 2.5 ± 1.1 mL), concentration (447 ± 24, 410 ± 24, 407 ± 24, 322 ± 24, 241 ± 31 ×106 sperm mL–1), vigor (5 ± 0.2, 4.8 ± 0.2, 4.4 ± 0.2, 4.2 ± 0.2, 4 ± 0.2), and sperm with normal morphology (92 ± 2.2, 90 ± 2.2, 87 ± 2.2, 80 ± 2.2, 81 ± 2.9%). Motility decreased (P < 0.05) following the fourth collection at 24-h intervals and decreased (P < 0.05) after the third collection at 48-h intervals. With a 24-h interval, 4 dogs had <60% motility lower at the fifth collection, whereas only 2 dogs had motility <60% on the fifth collection at 48-h intervals. In conclusion, semen collected at 48-h intervals was of better quality than semen collected at 24-h intervals.


The article discusses the method of improving the quality of computer-aided design of machine-building products based on the introduction of the concept of 3D drawing. A comparative analysis of the application of a 3D drawing and the use of a standard flat drawing for the manufacture of machine-building profile products on modern CNC machines is given. The 3D drawings of the products are developed in the SolidWorks software environment. Based on the analysis, it is concluded that the use of 3D drawings in compliance with their correct representation in computer-aided design systems will reduce the time for the manufacture of relevant parts.


Lymphoedema is a much under-publicised condition, yet it affects many people. Janice Bianchi and Marie Todd outline the implications of the condition and examine the treatment options of a typical case study.


Taking application of deep bed stirring method in one soft soil foundation work as example the factors influencing the standard strength of cement-soil are analyzed;at the same time corresponding construction technology and matters for attention are introduced. Practice shows the application of this method in reinforcement muddy acid soil acquired anticipated strength.


Chapter 1 Preface Chapter 2 Athens and Jerusalem: The Legacy of Leo Strauss Chapter 3 Strauss, Reason, and Revelation: Unraveling the Essential Question Chapter 4 A Word Fitly Spoken: The Interpretation of Maimonides and the Legacy of Leo Strauss Chapter 5 Maimonides' Conception of Philosophy Chapter 6 Leo Strauss and Jewish Modernity Chapter 7 Leo Strauss and the Fourth Wave of Modernity Chapter 8 Athens and Jerusalem or Jerusalem and Athens? Chapter 9 Philosophy and the Possibility of Revelation: A Theological Response to the Challenge of Leo Strauss Chapter 10 Afterword


The character of the domain structures in Ba1-xSrxTiO3(x=0.7,0.4,0.1) ceramics prepared by the solid-state reaction was investigated by piezoresponse force microscope(PFM) and transmission electron microscope(TEM).The PFM results indicate that the domains are induced in paraelectric phase Ba0.6Sr0.4TiO3 under 10V dc voltage applied between the tip and the bottom electrode.However,no domain appears in paraelectric phase Ba0.3Sr0.7TiO3 under the same external voltage.The polarization reversal occurs in Ba0.9Sr0.1TiO3 after application of 12V and-12V dc bias voltage.Furthermore,the TEM images show that no domain is found in Ba0.6Sr0.4TiO3,while the herringbone domain structure is found in Ba0.9Sr0.1TiO3.The mechanism of nonlinear dielectric properties of paraelectric phase Ba1-xSrxTiO3 ceramic is also discussed.


The use of marginal backfills in GSE (geosynthetic stabilized earth) walls has not been recommended by different standards specifications. Restrictions are motivated by the poor hydraulic conductivity of fine soils that are capable of developing of water pressures. However, the use of granular materials can expend the cost of the construction. As a result, local soils, granular or not, have been increasingly used. Unsaturated conditions of fine soils may result in convenient performance even using extensible reinforcements. This paper evaluates the performance of a full scale model of a nonwoven geotextile reinforced wall constructed with fine grained soil backfill. The unsaturated condition was maintained and matric suctions, displacements and reinforcement strains were monitored during the test. Results have shown that the unsaturated condition of the backfill allowed maximum reinforcement peak strain of 0.4 %. For the case of a wrap faced wall on a firm foundation the performance and good agreement between measured strains and factors of safety from limit equilibrium analyses have shown the maintenance of unsaturated conditions as an economical alternative to the use of high quality fill.


The uncertainties in a physical system can be modeled and analyzed by using probability theory or possibility theory, depending on the amount of information available. In probability theory, the uncertain variables are modeled using Probability Density Functions (PDF) and then propagated through the system to obtain its reliability. In the absence of sufficient data to model a PDF, possibility theory, in which variables are represented using fuzzy membership functions, can be used to propagate uncertainty. But when dealing with a combination of both probability distributions and fuzzy membership functions, the computational cost involved in estimating the membership function of reliability increases exponentially because one reliability analysis, which is a computationally expensive procedure, is performed at each possibility level to obtain the bounds on the reliability of the structure. To improve the computational efficiency, a technique that uses response surface models and transformations of possibility functions is presented in this paper. The efficiency and accuracy of the proposed methodology is demonstrated using numerical examples. I. Introduction The uncertainties present in the design process need to be quantified and propagated to obtain the reliability of a structural system. Based on the information available, these uncertainties might be quantified as random or nonrandom variables. When there is enough data about a particular quantity, a probability distribution can be assigned, and this random uncertainty can be propagated using existing probabilistic methods. In situations where sufficient information is not available for defining a probability distribution, fuzzy theory can be used to represent the available data in an analytical form. Using fuzzy theory, these variables can be represented by membership functions based on their possibility of occurrence or level of confidence. Once the input variables are defined as possibility functions, the possibility of the response can be estimated. But in most problems, information might be available to represent some variables with a probability distribution and some with a membership function. Therefore, this paper focuses on dealing with problems for which some uncertainties can be quantified using fuzzy membership functions while some are random in nature. In probability theory, the failure probability of a structure is obtained by solving the multidimensional integral dX


The invention relates to a loading and / or vent valve for a liquid tank of a motor vehicle, with a valve housing (10) having at least one fluidically connectable to an ambient environment opening (11) and at least one fluidically connectable to the liquid tank tank opening (12), and with at least arranged a movable between a first end position and a second end position in the valve housing (10) float (13) is provided which is arranged in the first end position and in at least one between the end positions interlayer said environment opening (11) and the tank opening (12) fluidly to connect and disconnect in the second end position said environment opening (11) and the tank port (12) fluidically from one another, wherein the float (13) is provided in the first end position to a flow cross section between the ambient opening (11) and to set the tank opening (12) in the Comparison is a flow cross-section in at least one intermediate layer made smaller.


This article discusses and analyzes a new measure designed specifically to track employee alignment and its drivers, named "EcQ® - The Strategic Alignment Monitor". How can managers identify whether employees support the company's strategic issues? The EcQ provides companies with a tool capable of measuring this alignment and reveals weaknesses and strengths in its drivers.


Osteo-arthritis is such a common disease that we are apt to take it for granted that we know all about it, and so fail to expend on the individual case that careful thought and unbiased consideration which the Hippocratic tradition demands of us. This state of affairs is made all the worse in view of the fact that osteo-arthritis is usually included under the general heading of rheumatic diseases, a curious medley when we consider that it is made to include such diverse entities as gout and rheumatoid arthritis, osteo-arthritis, and acute rheumatism. The result of this confusion of diseases whose aetiology and pathology are entirely different is that when a method of treatment is advanced which may be applicable to one of them, it is apt to be indiscriminately applied to all. Even in these days of comparative enlightenment we sometimes see salicylates given as a routine for osteoarthritis and vaccines for gout. It seems, therefore, that it may be worth while to consider certain aspects of osteo-arthritis about which I have found that confusion has arisen both in my own mind and in that of others. Definition


Background: To look into the incidence of lymphatic spread in Soft Tissue Sarcomas (STS) of the extremities and its relevance to the patient's prognosis. Patients & Methods: Retrospective review of 96 patients over a period of 5 years from 1999 to 2004 with a minimum follow up of 8 months. Complete data of every patient was reviewed with particular emphasis on lymph node and distant metastasis. All the patients were seen by one consultant and the histology reports were given by one Pathologist. 2 consultant radiologists were also involved in giving reports. Results: There were 39 males and 57 females with an average age of 51 years. The average duration of swelling at presentation was 6 months. There was a strong family history of cancer in first degree relatives in 23 patients (24%). Liposarcoma was the commonest tumour (22) followed by Leiomyosarcoma (19), Fibro sarcoma (14), Synovial Sarcoma (12), Rhabdomyosarcoma (10), Histiocytoma (9) and other rare sarcomas. The Trojani grade of the tumours was Grade 1 = 36, Grade 2 = 39 & Grade 3 = 21. No metastasis (mets) were found during pre op. screening in 71 patients (74%) while 11 (12%) had lung mets, 9 (10 %) had lymph node involvement and 5 had liver involvement (4 %). 4 had multiple organ involvement on presentation. All except 6 patients had either wide local or radical excision of the tumour. The average interval between presentation and definitive treatment was 28 days. 9 of the patients with lymph node mets underwent nodal clearance during primary surgery. 2 turned out to be reactive hyperplasia while 7 proved to be malignant. 22 of the 71 patients (31 %) with no mets pre op. developed mets during follow up at an average duration of 11 months (11 to lungs, 8 to regional lymph nodes, 2 to liver and one to bone. 4 patients had multiple mets) In addition to this, there was local recurrence in 12 patients of whom 9 had incomplete excision during primary surgery. Of the total 15 patients who had proven lymph node mets, 5 came from Rhabdomyosarcoma, 4 from Leiomyosarcoma, 3 each from Lipo & Synovial sarcoma. The average life span in patients with lymph node involvement was 13 months in total when compared to 31 months for others. As on 31-3-2005, 39 were dead and the rest were alive. The average life span of the patients who died from the time of confirmed diagnosis was 23 months. The average life span for Rhabdomyosarcoma was 8 months, Histiocytoma was 12 months, Liposarcoma was 19 months, Leiomyosarcoma was 28 months and Synovial sarcoma was 36 months. Patients with Trojani grade 3 STS died at an average of 9 months when compared to 38 months for grade 1. Discussion: There is a 16% spread to regional lymph nodes. It appears that lymph node involvement is indicative of micrometastatic disease elsewhere. Excision of the lymph nodes during primary surgery did not improve the life expectancy. Conclusion: Lymph node involvement is a poor prognostic sign While removal of clinically suspicious lymph nodes is reasonable, there appears to be little justification for treating clinically uninvolved draining regional lymph nodes Therapeutic lymph node dissection might be indicated as part of the palliative management The presence of regional lymph node metastasis at any time should be interpreted as an expression of systemic tumour spread and treated palliatively only.


Based on an exact mathematic model, a measurement method regarding core thermal power of nuclear power pressurized water reactor and it's error analysis were presented in this paper. The comparison results between KME system and SAPEC system for verification demonstrate that this method can be used for thermal power measurement.


The purpose of this research is to improve the discipline of new students of
VIIA class at Junior High School Number Four Lubuklinggau through applying
teacher modeling. The specific purposes of this research are: (1) to improve
the discipline of new students through applying teacher modeling in precise
time discipline ; (2) to improve the discipline of new students through applying
teacher modeling in neat dressed discipline ; (3) to improve the discipline of
new students through applying teacher modeling in learning orderly discipline
; (4) to improve the discipline of new students through applying teacher
modeling in doing assignment. The method used is action research. The
subject of this research are the students of VIIA class at Junior High School
Number Four Lubuklinggau. Researcher collaborator are teacher and the
parents of VIIA class students. Data collecting technique used are: (1)
observation ; (2) interview ; (3) documentation. Data analysis technique used
are percentage and average score. The result of this research are: (1) the
discipline of new students can be improved through applying teacher
modeling in precise time discipline ; (2) the discipline of new students can be
improved through applying teacher modeling in neat dressed discipline ; (3)
the discipline of new students can be improved through applying teacher
modeling in learning orderly discipline ; (4) the discipline of new students can
be improved through applying teacher modeling in doing assignment. The
conclussion is induceed by special conclussion suits to based on result and
research discussion as follows: (1) the discipline of new students can be
improved through applying teacher modeling in precise time discipline ; (2)
the discipline of new students can be improved through applying teacher
modeling in neat dressed discipline ; (3) the discipline of new students can be
improved through applying teacher modeling in learning orderly discipline ; (4)
the discipline of new students can be improved through applying teacher
modeling in doing assignment.


The relationship between the unipositional vector magnetocardiogram (VMCG) and the Frank vector electrocardiogram (VECG) was studied with a stepwise multiple regression analysis in 200 normal subjects and in 144 patients with myocardial infarction (MI). The calculated squared multiple correlation coefficient showed that at most 45% of the variation in the normal VMCG could be explained by the VECG. In MI group the predicting value of the VECG was smaller.


A parametric description of static output feedback stabililizing controllers for diffusion systems with Markovian switching is presented. This description is expressed in terms of coupled linear matrix equations and non-convex quadratic matrix inequalities which depend on parameter matrices similar to weight matrices in LQR theory. A convexifying approximation technique is proposed to obtain the LMI-based algorithms for computing of the gain matrix. These are non-iterative and used computationally efficient SDP solvers.The results are then applied to simultaneous stabilization of a set of diffusion systems, robust stabilization and stochastic passification problems. Finally, a numerical example is provided to demonstrate the applicability and effectiveness of the proposed method.


The application of information-oriented management on the medical cost of bank-medical card in the outpatient medical treatment process is introduced,and its advantages and problems in the application are analyzed.Some countermeasures are introduced to improve the effectiveness of conducting information-oriented management on the medical cost of bank-medical card.


Cottonseed (Gossypium herbaceum), bitter leaf (Vernonia) amydalina), cashew leaf (Anacardium occidentale), Piper nigrum (black pepper) and scent leaf (Ocimumgratissimum) are major ingredients used in preparation of the local soups namely; 'koroowu soup', 'black soup', 'cashew leaf soup' and 'ewe luje soup' consumed in certain parts of Nigeria. The ingredients for the soups were sorted according to the local preparations, separately blended into a paste and were either cooked or uncooked. The pastes were subjected to physicochemical (proximate, pH, total titratable acidity, mineral, phytochemical, antioxidant) and antimicrobial assays. The results showed that the cooked and uncooked pastes from these soups had pH ranged from 4.38-5.89, total titratable acidity (TTA) (0.05%-0.37%), moisture (9.30%-24.75%) and ash content (3.41%-7.17%). However, it was observed that the soup pastes were high in protein (10.39%-12.64%), fibre (13.82%-20.48%) and fat (21.11%-34.47%). The mineral content of the soups revealed that calcium ranged from 1.24ppm8.74 ppm, zinc (1.3 ppm-1.65 ppm), potassium (4.04 ppm-20.94 ppm) and sodium content (14.27 ppm-67.00 ppm). The phytochemical composition of the pastes showed that saponin (4.59mg/g-62.91 mg/g) was the highest, followed by phytate (15.24 mg/g-61.39 mg/g), alkaloid (0mg/g-27.84 mg/g), tannin (2.39 mg/g-6.57 mg/g), oxalate (0.72 mg/g-2.12 mg/g). The soup samples were found to exhibit free radical scavenging property (DPPH) of 30.0%-100%, 2,2'-azino-bis(3-methylbenzothiazoline-6-sulphonic acid) (ABTS) scavenging ability (70.0-100%), and ferric reducing power (2.73 mg/g-20 mg/g). However, the aqueous extract from the soup pastes could not inhibit the growth of microorganism tested. Further studies should be carried out to identify the bioactive compounds responsible for the antioxidant activities recorded from the soup pastes.


In order to solve the data matching problem between sports camera and lidar, a joint calibration optimization method of sports camera and lidar based on Levenberg-Marquard (LM) algorithm is designed. First, the calibration board is placed in the common field of view of the lidar and the sports camera, and the laser point cloud and image data of the calibration object at different positions are colected by changing the position of the calibration board. Then the fisheye distortion correction function is caled through OpenCV to correct the image distortion, and obtain multiple sets of pixel coordinates of the corner points of the calibration plate image. At the same time, point cloud filtering and point cloud registration are performed on the laser point cloud, and the laser point cloud is segmented by a combination of manual and automatic methods, and then the point cloud center iterative algorithm is used to solve the calibration board point cloud center coordinates and The point cloud coordinates of each corner point. Finaly, through multiple sets of point cloud coordinates representing the corner points of the calibration board and the corresponding image pixel coordinates, the direct linear transformation method (DLT) is used to calculate the initial value of the joint calibration between the two sensors, and the difference between the point cloud reprojection coordinates and the image pixel coordinates is constructed. The least squares function of, the function is optimized by the LM algorithm that introduces the damping factor, and the optimized joint calibration result is solved. Experiments show that the joint calibration result reduces the reprojection error by 35% compared with the initial value. The joint calibration result is used to achieve laser point cloud and image fusion based on the principle of colinear ch in aX iv :2 02 21 0. 00 20 1v 1 ChinaXiv合作期刊 22050000164010 10李红帅.fbd


The invention discloses a file scanning method and device. According to the file scanning method and device, a current storage space layer to be scanned is scanned to obtain a file stored in the current storage space layer to be scanned, then the path of the file stored in the current storage space layer to be scanned is calculated and analyzed to obtain the information of the file stored in the current storage space layer to be scanned, whether a file folder is stored in the current storage space layer to be scanned is judged, if the judged result is yes, the file folder serves as the current storage space layer to be scanned, the steps are executed again until no file folder is stored in the current storage space layer to be scanned, and the operation of file scanning is finished. Through the file scanning method, the scanning of the file, the calculation of the path of the file and the analysis of the information of the file are all carried out layer by layer, file canning of the next layer and the calculation of the path of the file and the analysis of the information of the file of the last layer can be carried out simultaneously, and therefore scanning time is shortened, and scanning efficiency is improved.


Food allergy (FA) has a significant impact on patients and families 'quality of life (1) and, considering that traveling is particularly anxiety provoking for children (2), many parents prefer to minimize the risk induced by such activities by avoiding them altogether (3).

This article is protected by copyright. All rights reserved.


The authors propose an efficient amelioration of the concept of large bandwidth aperture-coupled microstrip antennas by coupling a CPW line-fed slot to a microstrip antenna. The CPW fed aperture-coupled microstrip antenna investigated has a large bandwidth with high gain and low crosspolarisation levels, is compact with only one substrate, and may be easily connected to both passive and active components. A numerical model has been developed and the theoretical results are in good agreement with the experiments.


Many real-world networks are interconnected with each other. In this paper, we study the traffic dynamics in interconnected complex networks under an intentional attack. We find that with the shortest time delay routing strategy, the traffic dynamics can show the stable state, periodic, quasi-periodic and chaotic oscillations, when the capacity redundancy parameter changes. Moreover, compared with isolated complex networks, oscillations always take place in interconnected networks more easily. Thirdly, in interconnected networks, oscillations are affected strongly by the coupling probability and coupling preference.


SIR: I read, with great interest, in the May–June 2004 issue of the Journal, the recent study by Kagansky and colleagues that reported a low incidence of delirium in patients over age 75 with a hip fracture. 1 This team reported a cumulative incidence of delirium of 11.4%. Delirium was diagnosed using the Confusion Assessment Method (CAM) and the Delirium Rating Scale (DRS). The study evaluated patients for delirium at admission, 1 week after surgery, and 1 month after surgery. The study also excluded patients with severe dementia, severe hearing loss, and severe visual impairment. These are well established risk factors for delirium. The study does not describe the type of analgesia used or give any description of any intervention program to reduce delirium. Other studies have screened at daily intervals postoperatively, using the CAM, and have found a total delirium rate of 40%. 2,3 A study using DSM-IV criteria diagnosed delirium in 24.3% of hip fracture patients and 11.7% of elective hip replacement patients. 4 The prevalence of delirium during hospitalization has been found by some investigators to be highest from Days 2 to 5 postoperatively. 3 Another recent study found that 29.7% of patients developed delirium before surgery, but that a further 18.8% developed delirium postoperatively. This study, interestingly, found differences between the two groups in the types of risk factors for delirium. This finding suggests that different preventive strategies may be needed for these two groups. 5 I believe that the reported lower incidence of delirium in this study can be explained by the exclusion criteria used and the absence of any evaluation for postoperative delirium until 1 week after surgery. I believe that these methodological factors make it very difficult to draw any firm conclusions about a lower risk of delirium in patients with hip fractures in the over-75 age-group.


Lactobacillus acidophilus is one of the major microorganisms which are famous for their effects on cholesterol. In this study, we have investigated the effect of L. acidophilus ATCC 1643 on removing the milk cholesterol and additionally, we have immobilized L. acidophilus ATCC1643 cells in sodium-alginate and observed its effect on milk cholesterol removing. Also, we have researched about the effect of some factors including: bacteria cells number (both free and immobilized cells) and immobilized cells bead size on cholesterol removing rate and ultimately the extracted results were compared together. The results indicated that free cells could reduce cholesterol to lower than 0.5mg/100ml milk. Also, smaller bead size resulted higher cholesterol reduction. Increasing the number of immobilized cells showed significant effect on cholesterol removal to about 86%. Also, reusability of the beads showed that immobilized cells are active in cholesterol processing for three times.


Minister of Local Government and Labour Gunnar BergeMinistry of local government and labourGroundbreaking Ceremony - Scandinavian Casting CenterStatement in Lista 3th septemberDear Mr. Witt, honored guests, ladies and
gentlemen.It is a great pleasure...


With the rapid development of IC manufacturing industry, wire bonding, as a traditional interconnection method, continues to develop towards high density, high speed and high reliability. The loop profile significantly influences the reliability of wire bonding, and it is necessary to study the wire bond looping process. The loop profile of the bonding wire is determined by the tension and material property of bonding wire as well as the trace and structure of capillary, in which the capillary trace has a major impact on the wire bond loop profile. At present, in the production practice of semiconductor industry, the settings of capillary motion parameters are mainly based on engineering experience. The influence of capillary trace on the loop profile is still unclear, which induces the loop profile is difficult to control. In this study, the influence of capillary trace on the looping process was investigated by finite element method on the software ANSYS LS-DYNA. The simulation results show that the lower the loop height is, the closer the horizontal position of highest point is to the first bonding point, the larger is the von Mise stress of the first bonding point. Loop height can be increased by rising kink height, reducing flat length, and the span of the highest point. The curvature of loop can be increased by increasing the height of the capillary motion and conversion, while overlarge conversion angle deteriorates the reliability of the loop. When the horizontal position of the highest point of the loop is located between the first bonding point and the center of the loop, the loop profile has ideal tensile strength and stability. Therefore, using a suitable capillary trace to generate a well-structured loop is beneficial to improve the reliability of electronic packaging.


It has been 2 years since the National Center for Advancing Translational Sciences (NCATS) announced its intent to test a new strategy for establishing collaborations between pharmaceutical companies and academic partners to repurpose company agents (new molecular entities and biologics) that were phase 2a–ready, but had not been approved by the Food and Drug Administration (FDA) for licensure. The new strategy would use template agreements to allow an academic institution and pharmaceutical company to quickly reach an agreement about the terms of the collaboration. In May 2012, NCATS posted template collaborative research agreements and template confidential disclosure agreements for use by collaborating academic institutions and the pilot program's first three pharmaceutical company partners, AstraZeneca, Eli Lilly and Company, and Pfizer. At the same time, NCATS published a request for information to get feedback on the template agreements. The initial response from academic institutions on the template agreements was not one of overwhelming enthusiasm. Although collaborations between academic institutions and pharmaceutical companies have been going on for years, the willingness of academic institutions to use template agreements that the NIH had drafted with pharmaceutical companies remained to be seen.

A little more than a month later, five more companies—AbbVie (formerly Abbott); Bristol-Myers Squibb Company; GlaxoSmithKline; Janssen Research & Development, LLC; and Sanofi—had joined the effort, and NCATS made a limited amount of company-provided information about each agent, along with the funding opportunity announcements (FOAs), publicly available on its website. The objective at that stage was to provide sufficient information about each agent to enable researchers to decide whether any of the agents might be a candidate therapeutic for their disease of interest based on a high-level view of the safety profile, duration of previous trials, and the original indication for which the agent had been developed. The scope of the pilot limited investigators to using the agents in their original formulation and with short periods of support (2–3 years) to complete phase 1b and 2a clinical trials. Modification of the agents was not an option.

With only a 2-month lead time between release of the agent information and the preapplication deadline, investigators from institutions across the country submitted almost 160 preapplications for a wide array of diseases. NCATS used external experts familiar with the mechanisms of action, the diseases, and drug development to evaluate the ideas proposed for new uses of the agents in the preapplications. Only after evaluation and NIH selection of the top preapplications and those of high program priority did investigators have their first direct contact with the companies to discuss their ideas and get more information on the agents. And it was the first time that the companies got a glimpse of the ideas from prospective academic partners for their agents.

At that point, the confidential disclosure agreements were executed and data shared in both directions so that the two parties could decide whether an application requesting funding for the academic research team should be submitted to the NIH. To be accepted for review and funding consideration, an application had to contain a letter of support from the pharmaceutical company stating that the agent and associated data needed for filing an investigational new drug application would be provided if the NIH made an award. To provide such a letter, companies presumably needed to have a collaborative research agreement in place. The template agreements served their intended purpose. Applications complete with letters of support from the companies were submitted and reviewed; 6 months after applications were submitted, NIH issued awards.

Unlike many of its sister institutes and centers, NCATS does not focus on a disease or organ system, which puts the center in the advantageous position of being able to support a wide range of projects with the strongest links between indications with unmet medical needs and the agents' mechanisms of action. As a result, the supported pilot projects cover a broad swath of medicine: Alzheimer's disease, alcohol dependence, nicotine dependence, schizophrenia, calcific aortic valve stenosis, peripheral artery disease, and two rare diseases—lymphangioleiomyomatosis (LAM) and Duchenne muscular dystrophy.

The rationale behind crowdsourcing (publicly advertising these well-developed pharmaceutical assets) to repurpose investigational drugs was to tap a much broader community of scientists for new therapeutic use ideas for these industry-held agents. By definition, NCATS expected that the proposed new therapeutic uses would differ from the indications originally investigated by the pharmaceutical company. What wasn't expected was the extent to which this occurred. Examination of the nearly 160 preapplications showed that 15 of the 16 compounds that received 5 or more applications had at least 3 diverse indications proposed. We see this diversity reflected among our awards. The Alzheimer's disease study and the LAM study are both investigating an AstraZeneca Src tyrosine kinase inhibitor originally developed for cancer treatment.1–4 Although this kind of complete shift in therapeutic indication is somewhat expected and is the very premise of repurposing, the extent to which this occurred—at least three different ideas in addition to the original indication(s) investigated by the pharmaceutical company—was rather remarkable and speaks to the power of using a crowdsourcing strategy for repurposing.

It will be a few years before we know what the success rate is of phase 2a clinical trials established using this strategy, but enthusiasm in the academic community and in the pharmaceutical industry is high. Harnessing that enthusiasm, in May 2014, NCATS issued a new set of FOAs for the New Therapeutic Uses program. This time, several NIH institutes and the FDA Office of Orphan Product Development joined the effort. Also new this round is an FOA for pediatric indications. Based on the experiences in the pilot, NIH institutes and the pharmaceutical companies recognized that with an additional year of support, investigators could conduct FDA-required juvenile toxicity studies. As a result, 12 agents have been listed for pediatric indication consideration. As in the pilot, NCATS required each pharmaceutical company to offer at least three agents to participate in the program. Holding the bar even higher, NCATS also required that new agents be listed; agents could not have been listed for the pilot. The only exception was that agents from the pilot could be posted for pediatric indications because those indications were not encouraged in the pilot.

With some agents in this round targeting completely new mechanisms of action, we expect to see fresh ideas from the research community and anticipate diverse hypotheses for the agents as was seen in the pilot. Awards from this new round of the program will be made in summer 2015, and we will soon begin seeing preclinical study results from the projects awarded in the pilot.


Wireless Sensor Network (WSN) applications have become more and more attractive with the miniaturization of circuits and the large variety of sensors. The different application domains, especially critical fields of WSN use, make the reliability of data acquisition and communication a hot research field that must be tackled efficiently. Indeed, the quality of largely used, cheap-cost wireless sensors and their scarce energy supply support these reliability challenges that lead to data loss or corruption. For solving this problem, the conception of a reliability mechanism that detects these shortcomings and recovers to them becomes necessary. In this article, we present a survey on existing reliability protocols conceived especially for WSNs due to their special features. The deep classification and discussion in this study allow for understanding the pros and cons of state-of-the-art works in order to enhance the existing schemes and fill the gaps. We have classified the works according to the required level of reliability, the manner to identify the origins of the lack of reliability, and the control to recover this lack of reliability. Across the discussion along this study, we deduce that the cross-layer design between MAC, routing, and transport layers presents a good concept to efficiently overcome the different reliability holes.


This issue presents topics on the advances in fiber-optic sensor technology, fiber-optic gyroscope, fiber-optic position and pressure sensors, fiber-optic magnetic and temperature sensors, and generic fiber-optic sensors. Papers included are on a novel analog phase tracker for interferometric fiber-optic sensor applications, recent development status of fiber-optic sensors in China, the magnetic-field sensitivity of depolarized fiber-optic gyros, a depolarized fiber-optic gyro for future tactical applications, fiber-optic position transducers for aircraft controls, and a metal embedded optical-fiber pressure sensor. Attention is also given to a fiber-optic magnetic field sensor using spectral modulation encoding, a bare-fiber temperature sensor, an interferometric fiber-optic accelerometer, improvement of specular reflection pyrometer, a theoretical analysis of two-mode elliptical-core optical fiber sensors, and a fiber probe for ring pattern.


e13548 Background: Lipegfilgrastim is a once-per-cycle fixed-dose glycoPEGylated granulocyte-colony stimulating factor (G-CSF) under development for the prevention of severe neutropenia in cancer patients receiving chemotherapy (CTx). PEGylation of a molecule extends its half-life in the body, requiring less frequent dosing and allowing for administration of G-CSF once per CTx cycle, making treatment potentially less expensive and enhancing patient compliance and safety. Briefly, traditional PEGylation methods use chemical conjugation through reactive groups on amino acids, which may reduce protein activity and result in non-uniform chemical and pharmaceutical properties. Here, we describe a highly site-specific GlycoPEGylation technology for site-directed PEGylation and summarize preclinical findings compared with pegfilgrastim (Neulasta). Methods: Glycosylation sequon scanning was used to identify the glycoPEGylation site with least impact on protein activity. E. coli-expressed G-CSF was selectively gly...


Nowadays the cloud system receives requests from a wide horizon of users. In order to execute a large number of modern resource-intensive, latency-sensitive applications with deadline requests from the users, the cloud systems are equipped with powerful machines, and the machines run for a significant amount of time. This leads to an increase in the probability of failures of these machines. Hence, the reliability of the cloud system is to be duly considered while designing a scheduling strategy for executing resource-intensive, latency-sensitive applications on it. This paper proposes an efficient scheduling strategy for executing real-time applications (scientific applications) maintaining the reliability constraints of both the cloud system and applications and the deadline constraints of these applications. The proposed policy assigns recoveries for an optimal number of tasks of the application while scheduling them on the cloud considering the reliability constraints of both the cloud system and the application. The experimental evaluation proves that the proposed policy outperforms the state-of-the-art policy both for the synthetic task set and scientific workflows.


In the long-distance operation of the high-temperature superconducting (HTS) magnetic levitation (maglev) systems, the dynamic characteristics of the vehicle are closely related to its security and stationarity, which require in-depth research to ensure its safe operation. Thus, we investigated the dynamic characteristics of the HTS maglev and assessed its safety and stationarity when running on a ring test line. In the experiments, the important parameters related to safety are lateral displacement (LD) and levitation height (LH). Results show that an appropriate low field-cooling height (FCH) is beneficial for its safe operation, and the maximum LD (MLD) should be considered in vehicle designs. Moreover, in other experiments, we tested the vibration acceleration of the HTS maglev vehicle using acceleration sensors and assessed its stationarity according to the Chinese National Standard GB5599-85, which is specifically published to assess the stationarity and security of railway vehicles by the China Ministry of Railways. The stationarity of the HTS maglev vehicle running on the ring test line is of good grade. When the secondary suspension and appropriate measures of vibration reduction are considered, the stationarity will be greatly improved.


Efficacy of several large-scale flow parameters as transition onset markers are evaluated using direct numerical simulation (DNS) of boundary layer bypass transition. Preliminary results identify parameters (k2D/ν) and u′/U∞ to be a potentially reliable transition onset marker, and their critical values show less than 15% variation in the range of Re and turbulence intensity (TI). These parameters can be implemented into general-purpose physics-based Reynolds-averaged Navier–Stokes (RANS) models for engineering applications.


Free amino acids and fatty acids of seven Basidiomycetes belonging to the families Hygrophoraceae and Russulaceae were determined. Pro, Glu, Ser and Val are the main free amino acids. Linoleic, oleic and palmitic acids are essentially the only fatty acids.


Six new metal–organic coordination polymers (CPs) [Ni(L)(2,5-TDC)(H2O)]n(1), [Ni(L)(1,3-BDC)(H2O)]n (2), [Ni(L)(1,4-BDC)(H2O)]n (3), [Mn(L)(2,5-TDC)(H2O)]n (4), [Mn(L)(2,6-PYDC)(H2O)]n (5) and [Mn(L)(1,4-NDC)]n (6) were achieved by reactions of the corresponding metal salt with mixed organic ligands (L = 3,6-bis(benzimidazol-1-yl)pyridazine, 2,5-H2TDC = thiophene-2,5-dicarboxylic acid, 1,3-H2BDC = isophthalic acid, 1,4-H2BDC = terephthalic acid, 2,6-H2PYDC = pyridine-2,6-dicarboxylic acid, 1,4-H2NDC = naphthalene-1,4-dicarboxylic acid) under solvothermal condition. CPs 1–6 were characterized by single-crystal X-ray diffraction, IR, TG, XRD and elemental analyses. Their structures range from the intricate 3D CPs 1, 3, 4 and 6 to the 2D coordination polymer 2 and the infinite 1D chain 5. The CPs 1–4 and 6 underlying networks were classified from the topological viewpoint, disclosing the distinct sql (in 1), pcu (in 3 and 6), new topology (in 2), and dia (in 4) topological nets. Moreover, analysis of thermal stability shows that they had good thermal stability. Finally, magnetic properties of CPs 1–6 have been studied, the results showed that complex 2 had ferromagnetic coupling and complexes 1, 3–6 were antiferromagnetic.


A three-dimensional numerical model has been developed to simulate a proton exchange membrane fuel cell. The governing equations were discretised and solved using a finite-volume technique and the numerical results were verified by empirical test results. In the numerical procedure, the species, temperature and protonic conductivity distribution in various voltages were modelled with great accuracy. The results have shown that by lowering the cell voltage, the maximum temperature at the cathode catalyst–membrane interface will increase. The effects of semi-circular and semi-elliptical gas channel cross-sections on cell performance were studied and compared with base model results. This showed that the elliptical model generates more current density at the same voltage. On the other hand, oxygen distribution is more uniform in geometries in which the value of cathode overpotential has a direct link with oxygen magnitude. Cathode overpotential is also sensitive to shoulder width and oxygen distribution; so ...


In this paper, we give a sequence of identities defining the product pseudovariety J 1 * H generated by all semidirect products of the form M * N with M ∈ J 1 and N ∈ H (here J 1 is the pseudovariety of semilattice monoids and H is a locally finite pseudovariety of groups). A sequence of sets of identities ultimately defining J 1 * G p results (here G p is the pseudovariety of p-groups).


Now a day, the natural preservatives are such an important system into the industrial products that guarantee trust in costumers. The present project has as a purpose to elaborate sausage (salami) of quality with natural additives such essential oil (rosemary and lemon) that have vitamins and increase the body strength. Also with this research, people are going to take advantage of natural additives with two types of oil which was made as the next way: washing and disinfected of the equipment, reception of feedstock, cut up, weight up. It was evaluated by students of the agroindustry career through surveys in order to know the main characteristics of the product as taste, texture, color and checking that the best treatment was the 6% of lemon essential oil. The results of the physical - chemistry analysis of the best treatment were 10,30% ash, 21%50 humidity, 36.60%fat, 35.50% protein,0,329% dietary fiber, total carbohydrates 0%. The cost of the production of salami is 9.60 dollars per each pound of salami and the essential oil extraction of each 10ml bottle $11.10.


The article deals with the National Programme for the Development of Education, stipulated by the Czech government and called White Book. It concentrates on the process of how this document was devised and elaborated, leading to analysing the main strategic lines of the Czech education policy: the implementation of lifelong learning for all; adaptation of educational and study programmes to the needs of life in the knowledge society; monitoring and evaluation of the quality and effectiveness of education; support for the internal transformation and openness of educational institutions; transformation of the role and professional perspectives of the educational and academic staffs; transition from centralised administration to responsible participation in decision-making.


1. Kanto Plain is thickly covered by the Quaternary volcanic ashes supplied from the volcanic chain running from the north to the west of the region, and offers one of the type areas in the tephrochronologiocal study in Japan as well as the type areas of the Japanese marine Pleistocene. Most of the Quaternary volcanic ashes distributed in the Kanto region are composed of the weathered ashes in the Pleistocene epoch, and have long been called "the Kanto Loam" by many authors. A discovery of stone implements from the Kanto Loam at Iwajuku in 1949 stimulated a close investigation of Loam, and knowledges about Kanto Loam have remarkably advanced for these ten years in such fields as stratigraphy, geomorphology, archeology under the co-operation of many investigators. 2. Kanto Loam formation is generally thick on higher terraces and thin on lower ones. Therefore, we can establish the stratigraphic division of the formation to terrace topography. In South Kanto, the Loam member which conformably covers the Tachikawa terrace gravel is named Tachikawa Loam, and what merges downward into the constituents of the Musashino terrace is named Musashino Loam. What conformably lies on the marine Shimosueyoshi formation (upper Pleistocene) is Shimosueyoshi Loam, and the lowest division of Kanto Loam is Tama Loam which is defined as the loam which ~ covers the Eyabugaura formation (middle Pleistocene) or its correlatives on the Tama terraces. 3. Tachikawa Loam member, the uppermost of the Kanto Loam formation, is brilliant brown in color, 3 to 4 meters thick in Tokyo, and is mainly composed of weathered scoriae. Distribution of the loam is very wide, covering the present -l andsurface. Two dark colored bands made up of buried soil which are recognized in the middle part of the loam can be pursued extensively as key beds. Tachikawa Loam can be divided into the upper and lower submembers at


Method for segmentation of 3D structures in CT and MR are provided. This method is based on the 3D ray propagation by mean movement analysis using the smoothness constraint. Ray propagation can be used to guide the development surface from good computational efficiency and shape priors is incorporated for robust convergence. The method includes the following steps: receiving a 3D image data (302); to visualize on the 3D image data display device (304); the 3D image by placing the seed in the structure selecting one of the structure to the data (306); to ensure that one surface to initialize the plurality of radiation from the seed is formed (308); determining the respective speed function of the radiation (310 , 312); that to develop the surface by propagating radiation the plurality of based on the respective speed function of the radiation (316); a plurality of radiation to converge on the boundary of the structure (318); and when all of the plurality of radiation is converged on the boundary of the structure, to the segmentation of the structure (320)


The research of Chinese criminal policy is relatively simultaneous with the process of reform and opening.The research has made great achievements and the characteristics and problems are also outstanding.Summarizing the Chinese characteristics of the research of criminal policy and analyzing its forming reasons have a significant meaning in flourishing the research of Chinese criminal policy,guiding the practice of criminal policy scientifically and effectively promoting the construction of a socialist country ruled by law.


Episcleritis is an acute unilateral or bilateral inflammation of the episclera and can be of two types: diffuse (more common: 70%) and nodular (30%).[1] While the data regarding its epidemiology is sparse, an incidence of 41/100,000 and prevalence of 52.6/100,000 population are reported in northern California, with middle‐aged females being the most commonly affected.[2] The pathophysiology is related to the inflammation of the episcleral vascular network, causing an increase in vascular permeability and vasodilation.[1] The etiology of episcleritis is mostly idiopathic. In 26%–36% of cases, associated systemic disorders are present, such as rheumatoid arthritis, ankylosing spondylitis, leukemia, lymphomas, temporal arteritis, and syphilis.[1] This case report is intended to emphasize the rare association between nodular episcleritis and Takayasu's arteritis (TA) in adults, which has not been reported in the literature to date.


Objective To investigate the serum lipid relation between men and women of differen t age and compare serum lipid in different decades with reference data.Methods Analysis of serum lipid from 599norm al persons and count the data.Result Regardless of men and women,TC and TG would rise with the increasing of age(TC:rm =0.70,rf =0.86,TG:rm =0.89,rf =0.96).HDL -c is of small variation with age;TC of 20-50y men higher than wom-en.after 50y women' s is higher,men' s TG is higher than women in same decad es .HDL -c of women is generally higher than men.Except 40-49y men before 50y,TC?TG of both men and women are smaller th an upper limit data ,the difference could be available in statistics(P 0.01).HDL -c is generally higher than upper limit data(P 0.01).Conclusion The relation of serumlipid between a ge and sex is considerable important ,and the reference data could be changeable in different decades of age and sex .


Surface texturing has become an increasingly prevalent approach to improve the tribological properties of materials. The present work aims to study a novel texturing technology. A copper coating with a porous surface structure was directly prepared on stainless steel using a copper sulfate solution bath via high-speed jet electrodeposition. A fine, uniform honeycomb structure with micron sized pores can be achieved using a pulsed current. The duty cycle, current density and current frequency of the pulsed current have a notable influence on the microstructure of the deposited surface. Decreasing the duty cycle and increasing the current density can help to achieve a homogeneous and fine porous surface. The mechanism for depositing a porous surface was discussed according to the roles of the current parameters in the formation of the coating microstructure.


Logistics has drawn much attention from enterprises and scholars because it is a major source of company profit.Although logistics outsourcing has become an important strategy for companies to lower costs and achieve competitive advantages,the problem of ordering newsvendor products creates demand uncertainty and causes challenges in business management.If a company outsources its order management of newsvendor products to the third party logistics(3PL),the risk brought by uncertainty demand would be shared between the firm and 3PL.When outsourcing order management,the firm outsources part of operational risks to 3PL.Furthermore,3PL is not only the agent of a company's logistic activities but also a sharer of risks.Such kind of cooperation will definitely change the performance of participators.To analyze these changes,we develop the profit models for the situation that 3PL manages orders for the retailer.We analyze the impact of risk changes and the proportion of loss allocation on the profit of the retailer and 3PL.The results show that risk has a negative role in increasing the total profit while the proportion of loss allocation's impact on the total profit is uncertain.When the proportion of loss allocation is too low,3PL could not play the risk-sharing role.But when the proportion is too high,the optimal order quantity will decrease heavily and both of the retailer and its 3PL will lose money.Thus,only when the proportion of loss allocation changes in a proper range,the interests of cooperation can be achieved.Comparing with the profit of the company and 3PL when the retailer manages its order decision,we find that there is a problem that 3PL may not be compensated for the risk it shares if the commission which the retailer pays to 3PL is very little.Therefore,the commission has a role to adjust the profit of each other so that every participator will be compensated for sharing the risk.Although their profit is affected by the proportion of loss allocation and the amount of commission,the optimal order quantity and sales price increase when 3PL manages order decision.Thus,if the proportion of loss allocation and the amount of commission change in a certain range,3PL-managed order will bring both of the retailer and its 3PL more profit.The greater the risk,the more benefit the retailer and 3PL will gain when they cooperate with each other.


In a context of an increasing part of the intermittent renewable sources of energy in the electrical power systems, the HPP have a major role to play in providing reserves because of their flexibility. Concerning the frequency control, the structure and parameter settings of turbine governing systems need to be adapted to the new requirements of the NCs; this can be possible with the help of recent developments in the digital control systems and numerical simulation techniques.


The common bean is a culture with a short vegetative cycle, highly susceptible to weed interference. The objective of this work was to evaluate the efficacy of herbicides applied in pre emergence for Digitaria sanguinalis control in "Carioca" bean crop, as well as to determine their selectivity to the crop. The treatments evaluated were: S-metolachlor (960; 1,440 and 1,920 g ha-1), alachlor (1,440; 1,920 and 2,400 g ha-1), and two untreated checks without herbicide application (with and without hoeing control). Visual evaluations of control for D. sanguinalis and injury to the common bean plants were conducted at 20 and 40 days after emergence (DAE). At all the evaluated rates, the herbicides were efficient in D. sanguinalis control. At 40 DAE, injury to the common bean was observed in the plots sprayed with S-metolachlor at the highest rates, but without deleterious effect on the crop grain yield. Despite being efficient in D. sanguinalis management, alachlor caused phytotoxicity to the "Carioca" common bean, reducing crop yield up to 47%.


The contamination level with ochratoxin A, aflatoxin and zearalenone was tested in 5 samples of corn flour from five samples different trade marks. Two of those samples showed contamination with ochratoxin A between 1,25-2,5 μl/g flour, contamination with aflatoxin and zearalenone was not detected.


The disclosure relates to a preview image display method and device. The preview image display method is realized by steps: determining whether a human face exists in images acquired by a camera in a first duration, amplifying the human face in the images acquired by the camera in a second duration, displaying the amplified human face as a preview image to be displayed through a display screen, and when receiving a shooting command, shooting the images acquired by the camera according to the shooting command. In the method, a human face image is displayed after amplified, so that a user can see own face details clearly even when using a selfie stick to take photos.


The invention relates to the field of polymer chemistry and relates to sulfonated polyaryl compounds, can be used, such as in ion exchange membranes in fuel cells, and a process for their preparation and their use. Object of the present invention is resistant to hydrolysis and thermally stable to provide sulfonated polyaryl with a defined degree of sulfonation and location from which the membrane materials can be produced with an improved resistance to hydrolysis. The object is achieved by sulphonated polyaryl compounds according to at least one of the general formula (I) - (IV)


Introduction: Historical Biography and Rival African Nationalisms Imagining the Nation: Methodism, History and Politics in Nkumbula's Early Years 'The Father of Zambian Politics' between Padmore and Maala The Explosion of Contradictions Nkumbula, UNIP and the Roots of Authoritarianism in Nationalist Zambia Resisting UNIP: Liberal Democracy and Ethnic Politics in Zambia's First Republic 'The Last Battle I Will Ever Fight': Nkumbula and the Drive towards the One-Party State Epilogue: Nkumbula's Last Initiatives and Legacy


A technology to replace the traditional blood sampling method for glucose monitoring has been sought for a long time. It is now possible to measure the blood glucose change rate continuously for more than 24 hours using a minimally invasive method that does not involve blood collection. Furthermore, various technology development efforts are being made for innovative diabetes management through intermittent or continuous blood glucose monitoring in a non-invasive manner. In this paper, we present an overview of diabetes and the need for continuous blood glucose measurement techniques., and then introduce various non-invasive blood glucose measurement techniques currently being studied. In addition, through research and analysis of the recent commercialization development status of minimally invasive, non-invasive, and wearable continuous blood glucose measurement technologies, we examine global development trends of future technologies.


With the intensification of livestock breeding and the growing demand for meat in the population, producers in order to increase the productivity of farm animals widely apply various feed additives: amino acids, minerals, enzymes, hormones, tranquilizers, antibacterial substances, antioxidants, flavors, dyes, etc. Hormonal supplements or growth promoters used in feeding farm animals, leads to a violation of metabolic processes in the body of animals and poultry, while there are changes in the structure and chemical composition of the biological value of meat. The consumption of such products by a person affects metabolic processes of the organism, hormonal background, endocrine system, breaking the work of the organism as a whole. The purpose of the work was to conduct a search to determine the presence of zeranol, a growth stimulator for ruminants in beef, which arrives at the slaughter shops of the Ternopil and Lviv regions. The determination of zeranol in meat was carried out using a test system for the enzyme immunoassay of RIDASCRIN® Zeranol (manufactured by Ar-Biopharm / R-Biopharm, Darmstadt, Germany). It was found that on average 36% of the samples of beef carcasses entering for processing contained a stimulant for the growth of the mass of ruminant synthetic stimulant-anabolic zeranol, that is below the detection limit of zeranol 0.062 μg/kg. Detected samples, in which the content of zeranol was lower than the limit of this method, indicates that, according to the sensitivity of this method, these tests were attributed to negative ones, that is, zeranol is absent. Two companies with the highest levels of zeranol were also found: it is a beef of MP "Plai", and PE "Fedoriv". Consequently, it is recommended that monitoring, sampling and selection of beef meat at meat processing plants be carried out in order to establish safety indicators, in particular, the content of zeranol. Planned monitoring will monitor and analyze the situation with regard to zeranol in Ukraine. The problem of food safety and the assessment of potential risks of meat is extremely complicated and requires the introduction of requirements for the control of this synthetic drug in the normative legal acts of Ukraine. It is also proposed to conduct research on the development of methods for reducing the quantitative content of zeranol in beefmeat during its refrigeration.


Regularizing images under a guidance signal has been used in various tasks in computer vision and computational photography, particularly for noise reduction and joint upsampling. The aim is to transfer fine structures of guidance signals to input images, restoring noisy or altered structures. One of main drawbacks in such a data-dependent framework is that it does not handle differences in structure between guidance and input images. We address this problem by jointly leveraging structural information of guidance and input images. Image filtering is formulated as a nonconvex optimization problem, which is solved by the majorization-minimization algorithm. The proposed algorithm converges quickly while guaranteeing a local minimum. It effectively controls image structures at different scales and can handle a variety of types of data from different sensors. We demonstrate the flexibility and effectiveness of our model in several applications including depth super-resolution, scale-space filtering, texture removal, flash/non-flash denoising, and RGB/NIR denoising.