Eucommia ulmoides oluv leaves,sugar and milk were fermented by yeast,acetic and lactic acid bacteria.The optimal technical parameters were determined by single factor and orthogonal experiments.The result showed that the optimal parameters were: the ratio of yeast Y I,acetic bacteria A II and lactobacillus L II was 2:3:2,inoculum was 140 ml/l,milk was 60 ml/l,and sucrose was 100 ml/l.Furthermore,the optimal fermentation conditions were: the powder of Eucommia ulmoides oluv 100 g/l,CaCO3 6 g/l,temperature 28℃~30℃,and fermentation time 2 d.Leach liquor,obtained from the fermentation,had good taste and unique flavor,with increased content of chlorogenic acid.


Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally. HCC may indicate intrahepatic multiple occurrence and intrahepatic metastases. Extrahepatic metastasis of HCC takes place in about 30-50% of patients, and it is determined by HCC stages. The location of extrahepatic metastasis of HCC is mainly the lung. Extrahepatic metastases to various unusual sites from HCC have been informed of several case reports. Metastatic malignancy of tongue is very rare, only one case of oropharyngeal tongue base, and we could not find any previous paper about HCC in dorsal surface of oral tongue in English literature. The author reports on a case of an extrahepatic metastasis from HCC in the oral tongue.


Two architectures for modulo 2 n +1 adders are introduced in this paper. The first one is built around a sparse carry computation unit that computes only some of the carries of the modulo 2 n +1 addition. This sparse approach is enabled by the introduction of the inverted circular idem potency property of the parallel-prefix carry operator and its regularity and area efficiency are further enhanced by the introduction of a new prefix operator. The resulting diminished-1 adders can be implemented in smaller area and consume less power compared to all earlier proposals, while maintaining a high operation speed. The second architecture unifies the design of modulo 2 n ±1 adders. It is shown that modulo 2 n +1 adders can be easily derived by straightforward modifications of modulo 2 n-1 adders with minor hardware overhead.


Turbidity currents are gravity currents in which the difference of density or weight difference between two fluids is because of suspended sediments. Considering sedimentation of turbidity currents in dams' reservoirs, hydrodynamic recognition of these currents will have great effect on increasing useful life of dams. So identifying hydrodynamic and characteristics of turbidity currents is very important in different fields. Using FLOW-3D and Fluent software velocity in the body of turbidity current has been modeled and compared to each other in this paper. The obtained results of numerical models of velocity profile in the body in inner regions (between bed toll maximum velocity) and in outer region (between the maximum velocities until the velocity gets almost zero) have relatively good compliance. Keywords-Turbidity Currents, Hydrodynamic, Velocity Profile, FLOW-3D, Fluent


This paper aims to offer a contextualized and multi-stakeholder perspective for creating a learning organization (LO) 2.0.,Based on a systematic review of the critiques of LO in the past three decades, this paper suggests some possible directions for the development of next-generation of LO (e.g. LO 2.0).,It is suggested that LO 2.0 should adopt a contextualized perspective by considering the social, organizational, cultural and industrial contexts to enhance the success of LO implementation and help fine-tune the universal LO model. Accordingly, LO 2.0 should adopt a multi-stakeholder perspective by incorporating multiple stakeholders during the process of design and implementation under the rationales of counteracting managerial dominance of low-power marginalized employees and mitigating the impacts of increased competition and technology advancement.,This paper provides some practical advice to business practitioners regarding how the practices of LO 2.0 can be adopted.,The study adds to the existing LO literature by further supporting and developing a contextualized and multi-stakeholder perspective to create the next generation of LO.


New ADCP courantologic measurements from some stations located in the northern part of the Wallis island lagoon, confirm the global circulation pattern described previously and provide details of circulations. Respective influences of parameters affecting the circulation (winds, tides and waves), are specified. Observations show the dominant outflow of the waters of the north-eastern part of the lagoon toward northwestern lagoon and the existence of a two layers circulation: a highly mobile surface layer with fast currents, influenced by oceanic swells inflows and winds with a weak influence of tides, a bottom layer with slower currents, but a stronger influence of tide and control of the bottom morphology. Thickness of the surface layer increases with the severity of meterologic conditions.


Thirty years old, a crisis took hold of British farming when it was discovered that bovine spongiform encephalopathy (BSE) in cows could leap the species barrier from cows to humans. Mark Greener examines the nature of vCJD and whether any cure is in prospect.


Biofouling is the accumulation of unwanted material on surfaces submerged or semi submerged over an extended period. This study investigates the antifouling performance of a new bioinspired topography design. A shark riblets inspired topography was designed with Solidworks and CFD simulations were antifouling performance. The study focuses on the fluid flow velocity, the wall shear stress and the appearance of vortices are to be noted to determine the possible locations biofouling would most probably occur. The inlet mass flow rate is 0.01 kgs -1 and a no-slip boundary condition was applied to the walls of the fluid domain. Simulations indicate that Velocity around the topography averaged at 7.213 x 10 -3 ms -1 . However, vortices were observed between the gaps. High wall shear stress is observed at the peak of each topography. In contrast, wall shear stress is significantly low at the bed of the topography. This suggests the potential location for the accumulation of biofouling. Results show that bioinspired antifouling topography can be improved by reducing the frequency of gaps between features. Linear surfaces on the topography should also be minimized. This increases the avenues of flow for the fluid, thus potentially increasing shear stresses with surrounding fluid leading to better antifouling performance.


The VPNG Country Conference was held on 22 February at the West Gippsland Arts Centre in Warragul with speakers organised by Todd Griffiths, NUM of the operating suite at the West Gippsland Health Group in conjunction with VPNG. The conference provided a great opportunity to catch up with some old friends and make some new acquaintances.


An experimental study on the strut load carrying capacity of steel tubes is described that investigates the influence of the residual stresses set up during the tubemaking process. The test results are compared with current column-strength curves from AS1250-1981, SSRC and ECCS codes of practice.


Studies on society and the environment interface are often based on simple questionnaires that do not allow for an in-depth analysis. Research conducted with geo-questionnaires is an increasingly common method. However, even if data collected via a geo-questionnaire are available, the shared databases provide limited information due to personal data protection. In the article, we present open databases that overcome those limitations. They are the result of the iTre-es project concerning public opinion on the benefits provided by trees and shrubs in four different research areas. The databases provide information on the location of trees that are valuable to the residents, the distances from the respondents' residence place, their attitude toward tree removal, socio-demographic variables, attachment to the place of life, and environmental attitudes. The presentation of all these aspects was possible thanks to the appropriate aggregation of the results. A method to anonymize the respondents is presented. We discuss the collected data and their possible areas of application.


This work is part of a project aiming at helping craftsmen to design and characterize their musical instruments. Starting from a given wind instrument shape, our objective consists in choosing the most relevant physical model able to predict the acoustical input impedance of this musical instrument once constructed. The modeling of bells in brass instruments is still problematic as the limits of plane wave approximation are known but no method is proven to give accurate results. The aim of the present paper is to compare the results given by di erent methods with measurements. Four di erent bells with known geometries are used in this study. These bells input impedances are calculated with a Boundary Element Method and with Transmission-Matrix Methods loaded with various radiation impedance models and based on axial or curvilinear abscissa. Surprisingly, a simple 1D wave propagation approximation based on curvilinear abscissa coupled with the radiation impedance of a pulsating portion of sphere gives results very close to the measurement. PACS no. 43.75.Fg, 43.20.Mv


OBJECTIVE: Economic studies increasingly guide health care resource allocation decisions. Because rigorous adherence to accepted definitions and research techniques is critical to ensure accuracy, we evaluated the terminology and methods of otolaryngology economic analyses. STUDY DESIGN: A total of 71 articles published from 1990 to 1999 in 6 peer-reviewed otolaryngology journals with terms such as "cost-effective" in their title or representing economic analyses were reviewed for terminology and use of established methodology guidelines. RESULTS: Over half (35 of 66) of terms such as "cost-effective" were used incorrectly, and 60% of articles (39 of 64) confused "charge" and "cost" data. Eleven percent (7 of 64) of papers specified the perspective of their analysis. About half (17 of 30) reported a summary measure such as a cost-effectiveness ratio. Only one third (23 of 63) performed sensitivity analyses. CONCLUSION: Adherence to accepted definitions and research methods is inconsistent, although we did note moderate improvements in making the distinction between costs and charges, defining of study perspective, and performing sensitivity analysis. SIGNIFICANCE: Greater attention to both terminology and methodology can enhance the quality of economic analyses and ultimately improve certain resource allocation decisions.


FIELD: physics. SUBSTANCE: method involves alternate generation of repeating images for the left eye and repeating images for the right eye; switching off the backlight device for a period of time, during which the left eye and right eye images are mixed, and switching on the backlight device for a period of time, during which only one of the left eye and right eye images is displayed; and controlling the shutter for the left eye and the shutter for the right eye in the 3D glasses for a period of time, during which the backlight device is on. EFFECT: eliminating crosstalk in stereoscopic liquid crystal device using liquid crystal 3D glasses. 42 cl, 20 dwg


It is shown that in the low-temperature plasma devices with pulsed external current circuits such as thermal emission converters and plasma diodes, the only forces inducing plasma flows are due to the temperature stresses on ions. These flows are similar to the plasma "residual" rotations in tokamaks. However, they are connected with the perpendicular viscosity dependence of the ion heat fluxes, contrary to tokamaks where the parallel viscosity plays the main role. Dust contamination of these devices can induce the temperature-gradient driven flows of ions, which also entrain neutrals in a multi-component partially ionized plasma.


Objective: To determine seasonal variation in the occurrence of stroke and its subtypes (ischemic stroke and hemorrhagic stroke) during summer and winter and to observe the frequency of common risk factors for stroke. Methodology: The present descriptive study was conducted in the Depart -ment of Medicine, MTI Lady Reading Hospital Peshawar, Khyber Pakhtunkhwa, Pakistan, over a period of one year from 1st January 2014 to 31st December 2014. A total of 321 patients of any age and either gender were included. The diagnosis was established based on history, clinical examination and supple-mented by CT scan of brain. Results: In winter 58.56% of patients and in summer 41.48% of patients were presented. Ischemic stroke was present in 66.04% patients while hemorrhagic stroke in 33.95% patients. Males had more strokes as compared to females (60.75% Vs. 39.25%). In males highest number of strokes was found in 60-69 age groups whereas in females it was in 50-59 age groups. In winter the strokes increased in all age groups comparative to summer. Hypertension (34.26%) was the highest risk factor for stroke. Conclusion: Stroke showed seasonal variation. Winter season was associated with increased frequency of stroke and its subtype of hemorrhagic stroke. There was variation of gender, season and stroke types in different age groups. Hypertension was found to be the highest risk factor.


In this paper, we revisit the question of the banks' ability to shift corporate income taxes to customers by increasing their net interest margins. We estimate tax incidence for 1,411 European commercial banks over the period 1992-2008. Unlike earlier studies which suffer from endogeneity problems or misspecification of the tax burden, we do not find any significant relationship between implicit taxes and interest margins. Our result is in line with the theory because income tax does not affect the profit maximization function and, consequently, should not be passed on.


The work is devoted to the investigation of the mechanisms forming a structure of a light field under interaction of electromagnetic radiation with the suspension of the biological particles. The basic asymptotic formulas are reduced. The effects of influence of the inner structure of the particles on the light-scattering pattern in a comparison with those of homogeneous particles are shown. The sphere with radially inhomogeneous profile of refractive index, coated sphere and coated sphere with refractive index with inhomogeneous profile of the outer layer were used as the models for description of light-scattering of the spherical biological particles with different inner structure.


Digital radiography incresingly is being applied in the fabrication industry. Compared to film- based radiography, digitally radiographed images can be acquired with less time and fewer exposures. However, noises can simply occur on the digital image resulting in a low-quality result. Due to this and the system's complexity, parameters' sensitivity, and environmental effects, the results can be difficult to interpret, even for a radiographer. Therefore, the need of an application tool to improve and evaluate the image is becoming urgent. In this research, a user-friendly tool for image processing and image quality measurement was developed. The resulting tool contains important components needed by radiograph inspectors in analyzing defects and recording the results. This tool was written by using image processing and the graphical user interface development environment and compiler (GUIDE) toolbox available in Matrix Laboratory (MATLAB) R2008a. In image processing methods, contrast adjustment, and noise removal, edge detection was applied. In image quality measurement methods, mean square error (MSE), peak signal-to-noise ratio (PSNR), modulation transfer function (MTF), normalized signal-to-noise ratio (SNR norm ), sensitivity and unsharpness were used to measure the image quality. The graphical user interface (GUI) wass then compiled to build a Windows, stand-alone application that enables this tool to be executed independently without the installation of MATLAB.


An experimental study of the effects of salinity on the mud-dwelling amphipod, Corophium volutator (Pallas), indicates that, if supplied with mud, it will survive the salinity range of 2.50 %0, and without mud the range 7.5-47–5 %0. Moulting occurred in salinities of 2.6–46 %0, but most frequently in the range 5–20 %0. Growth occurred at a maximum rate in 15.4 %0, and only slightly slower at 4.4 and 30.6 %0; but below 4.4 %0 the growth rate was progressively reduced. Freezing point studies show C, volutator to be a hyperosmotic regulator, having a tissue tolerance range of 13–50 %0. The importance of a supply of mud, and the significance of hyperosmotic regulation are briefly discussed. INTRODUCTION The amphipod Corophium volutator (Pallas) is an inhabitant of littoral muds, the populations often reaching high densities. It has been most commonly reported from shores of estuaries, although Zenkevitch (1963) has stated that it may also occur in muds submerged to a depth of 10 m. Segerstråle (1959) has summarized the data available on the occurrence and distribution of C. volutator. Since that date, work has been done on substrate selection (Meadows 1964a–c), on burrowing behaviour (Meadows & Reid, 1966) and on rhythmical swimming activity under tidal control (Morgan, 1965). Many authors (Nicol, 1935; Thamdrup, 1935; Beanland, 1940; Spooner & Moore, 1940; Rees, 1940; Goodhart, 1941; Stopford, 1951; Rullier, 1959; Gee, 1961) have described the substrate in which C. volutator occurs. They have agreed that C. volutator is found in mud or muddy sand, containing approximately 37 % silt or clay.


This research paper reports the employers' evaluation on UNISEL's Faculty of Business (FOB) students' performance during Industrial Training. Data was taken from FOB students of 4 bachelor degree programs who attended industrial training for 2 semesters in 2015. Employers from their respective work place were asked to rate the performance of students under the category of interpersonal skills, soft skills and knowledge and technical skills. They were also being evaluated on whether there will be any employment opportunities exist in the workplace for the students to embark their career. The main objective of this research is to focus on the factors influencing FOB's students' performances during industrial training. Apart from assessing the factors influencing the students' performances, the study also recognizes whether the respondents' background is a contributing factor to the students' performance during industrial training. The research also identifies the level of performance for the students during their training as well as looking into whether it correlates with the students' employment opportunities. This research may also be used as a platform to close any gaps that exists in the faculty's course learning outcomes as the employers' requirement on industrial training students are able to be perceived. This will enable the management to use the information obtained to improve on the current standards of teaching which will eventually and hopefully lead to students' employability in the job arena.


The growing practice of preprinting (that is, publicly sharing manuscripts via online servers prior to the completion of journal-organized peer review) is accelerating the dissemination of scholarly research in many fields. While multiple factors contribute to researchers' comfort levels with the practice, journal policies influence many authors' decision to submit a preprint (Figure 1). Fortunately, many journals are now changing their policies to allow or even encourage preprint posting, but navigating journal websites to find this information can be difficult and time-consuming. The SHERPA/ RoMEO database provides a fantastic way for authors to rapidly check whether a particular journal allows preprint archiving. However, policies themselves are often much more complex than their representation in SHERPA/ RoMEO, including clauses about versions of the manuscript that may be posted, acceptable servers, licenses that can be applied to preprints, and what media coverage is acceptable. In the following sections, we provide a sampling of the variation among journals (emphasis ours).


Objective To compare the effects of different doses of scopolamine on behavior,learning and memory function in mice and determine the appropriate dose of scopolamine for inducing memory impairment of mice model.Methods The total of 48 kunming mice were randomly divided into 4 groups(control group and three model groups,each containing 12 mice) were given with scopolamine by intraperitoneal injection at the doses of 2,3 and 5 mg·kg-1,and the same volume of saline,respectively.Learning and memory ability were investigated by avoidance reaction and the content and vitality of Ach,AChE and ChAT were determined by a spectrophotometric method.Results ① The latency period of scopolamine at 3 mg·kg-1 dose and 5 mg·kg-1 dose was significantly reduced(P0.05);②The vitality and content of AChE,ChAT and Ach in the brain of these mice were remarkably affected.Conclusion ①The degree of damage of scopolamine to the behavior and memory of mice is increased with the dose;learning and memory behaviors in mice were significantly injury by 3 mg·kg-1 dose and 5 mg·kg-1 of mice;② Scopolamine can significantly impact acetylcholine synthesis and metabolism in the cerebral cortex and hippocampus of mice at the doses of 3 mg·kg-1 and 5 mg·kg-1;③The appropriate dose of scopolamine on the behavior and memory function injury of mice is 3 mg·kg-1.


Strong spontaneous polarization and piezoelectric effects in hexagonal gallium nitride (h-GaN) seriously limit the efficiency of h-GaN-based devices. To overcome this issue, a pyramidal-shaped four V-grooved silicon (4PVG-Si) patterned substrate is introduced for transforming h-GaN into cubic GaN (c-GaN) at the nanoscale. The purpose of using 4PVG-Si instead of simple V-grooved Si (VG-Si) is to improve the crystal quality with the maximum cubic volume of GaN. The growth of c-GaN was verified by high-resolution x-ray diffraction and cathodoluminescence, whereas high-resolution transmission electron microscopy (HRTEM) was further used to analyze the excessive and smooth c-GaN growth. The HRTEM images revealed that optimizing the growth of an aluminum nitride layer with 10–15 nm thicknesses promotes the maximum c-GaN volume. However, exceeding this thickness tended to the reduction in c-GaN volume, resulting in the development of big voids with abnormal tip-shaped growth. In the presence of big voids and abnormal tip-shaped growth, the hexagonal growth closed very late, and the cubic volume of c-GaN is reduced. To further promote the cubic phase of GaN, the growth conditions of GaN were also optimized. Our results proved that the design of 4PVG-Si and optimized growth conditions promote the maximum cubic volume of GaN.


In recent years, the increasing burden on doctors due to the shortage of doctors has become a problem in the medical site, and CNN-based methods that can realize highly accurate diagnosis by image recognition are attracting attention as a method to automate diagnosis to ease the burden on doctors. However, in the medical site, it is required to provide explanations to patients, and CNN-based methods have not been introduced to the site because it is difficult to explain the results. Therefore, we proposed a method using Attention-Guided CycleGAN as a method to analyze the differences in regions and patterns recognized by CNN for the explanation of diagnosis using CNN, and evaluated the validity of analysis from the results of the transformation, the similarity of regions of focus, and the effectiveness of transformation for diagnosis using CNN. The results show that Attention-Guided CycleGAN may be effective for the analysis of CNN, because the transformation results are in line with symptoms between cardiomegaly and asymptomatic patients, and be also effective for diagnosis by CNN.


In order to set up the innovation ability and synthesize ability of solving problem, aim at the talented person of the troops college trains target and teaching characteristics, combinative my school actual circumstance, the aspects of automatically controlling theories course designing, teaching mode, experimenting link and graduating design has been courageous study and practice. The educating for innovation ability has been run through each link in the automatic control principle course teaching and become a complete training system and adapts to the need for the creative ability profession talented person for the new century and obtained the certain result.


With students having experienced dramatic changes to their lives and perhaps personally experiencing serious illness and death within their immediate or extended families due to the COVID-19 pandemic, schools may have to examine how to broadly implement the use of trauma-informed care in schools. This article examines why experiences related to the pandemic are considered traumas and what supportive practices have been identified in the research that educators can use to help students.


EZH2(enhancer of zeste homolog 2)attached to the family of polycomb group(PcG) proteins is the catalytic subunit of polycomb repressive complex 2(PRC2),and can methylate lysine-27 of histone H3 to induce the silence of some related genes.Most of these targeted genes play significant roles in inhibiting the tumors and regulating the differentiation of stem cells,and the silence of these genes will contribute to oncogenesis and pluripotency defects of stem cells.EZH2-mediated silencing machanism is believed to be closely interrelated to DNMTs and HDACs.The present review summarized the progression of EZH2 in embryonic stem cells,cancer reseach and clinical application perspective.


The Australian state of Victoria has a record of proactive and determined legislative action addressing road safety. Its processes and deliberations concerning the introduction of road safety laws serve as a noteworthy case study of political rationality and public policy development. Victoria has taken a unique and pioneering approach to traffic regulation. Using the seatbelt and handheld phone laws as examples, this article examines the political dynamics involved in, and the forms of political reasoning underpinning, the road safety policy decisions taken by Victorian governments. I argue that the different approaches taken by governments are partly due to the interaction of the political imperatives of state institutions imposing regulations for the public good and the protection of individual liberties.


Monitoring of populations of adult corn rootworms (Diabrotica virgifera and D. barberi) in Ontario (CA), and surveys of insecticide use against rootworms, showed that populations declined in the last 10 years and that the proportion of the maize area treated with rootworm insecticide has fallen to <7%. This proportion was directly correlated with the percentage of cropping with continuous maize. The area of insecticide-treated maize could be further reduced by educating livestock producers about the merits of crop rotation and the possibilities of alternative high-energy crops, such as winter barley. Populations of rootworm adults and area of continuous maize are currently so low in Ontario that there is a good probability of success for an adult monitoring and insurance programme to replace the use of corn rootworm insecticides. In Germany (where D. virgifera is now absent but may potentially be introduced from the outbreak in the lower Danube basin), the four Federal Lander of Niedersachsen, Nordrhein-Westfalen, Bayern and Baden-Wurttemberg maintain a high frequency of continuous maize. If areas with more than 50% of arable land with maize are considered to be at high risk of rootworm infestation, about 348 000 ha of maize fall into this category. This is a third of the maize production area of the above-mentioned Federal Lander and more than a fifth of the entire maize production area of Germany in 1995. On the basis of long-term experience of insecticide use in Ontario, there is a potential for treatment of up to 111 000 ha with rootworm insecticide (terbufos) annually in Germany, at an added insecticide cost of 13 million EUR per annum. Without crop rotation or treatment, rootworm infestations could cost German maize producers 25 million EUR in crop losses each year. The experience in Ontario suggests that Germany should follow a strategy of changing crop rotation away from continuous maize, so as to reduce the potential for establishment of D. virgifera, the potential for economic loss and the potential for increased reliance on insecticides.


A structural element for a motor vehicle comprises a front of the front of a motor vehicle, of the type comprising: - a metal cross member (4) and elongated hollow closed cross section; - two uprights of plastics material (6), each upright (6) continued and the second molding on the metal cross-member (4) and each upright (6) being, in each cross section of the metal beam (4), entirely situated on the outside contour of the metal beam (4), characterized in that each upright (6) comprises at least two sleeves (24) surrounding the metallic cross (4), the sleeves (24) of each upright (6) are separated longitudinally, and the ratio of the axial length (l) of each sleeve of an upright (6) to the longitudinal distance (e, e1) between the sleeves (24) of the upright (6) is less than 1.


Genomic instability is a recognized hallmark of cancer. Germline mutations in critical DNA-repair and DNA-damage response genes, including BRCA1and BRCA2, predispose to cancer development, but also create vulnerabilities that can be exploited for cancer therapy. The successful development of PARP inhibitors for cancers with BRCA1/2 mutations and a deficiency in homologous recombination DNA repair has provided proof of concept. Inhibition of kinases that promote transcription of DNA repair genes might provide targets that enhance the activity of PARP-inhibitors. One novel candidate, salt-inducible kinase 2 (SIK2), is overexpressed in approximately 30% of high grade serous ovarian cancers. Inhibition of SIK2 induces tetraploidy, triggers apoptotic cell death, prevents metastasis, reduces AKT/survivin signaling and decreases phosphorylation of class-IIa histone deacetylases (HDACs) enhancing inhibition of gene expression. In contrast to other HDACs, class-IIa HDACs function as signal-responsive transcriptional corepressors for the myocyte enhancer factor-2 (MEF2) family of transcription factors. MEF2s play important roles in regulating growth factor responses, neuronal survival, T-cell apoptosis and, importantly, B-cell DNA double strand break (DSB) repair. Here we ask whether inhibition of SIK2 can enhance HDAC class-IIa inhibition of MEF activity, decrease DNA repair and enhance sensitivity to the PARP inhibitor Olaparib in ovarian cancer cells. Treatment with SIK2 inhibitors (ARN3236 or ARN3261) enhanced sensitivity to Olaparib in each of 8 ovarian cancer cell lines without BRCA1/2 mutations (OC316, OVCAR8, IGROV1, A2780, HCC5030, HCC5032, SKOv3 and OVCAR5) and significantly reduced the IC50 of Olaparib in two PARP inhibitor-resistant ovarian cancer cell lines (A2780CP-R and UWB1-289-10R). Synergistic cytotoxicity, judged with a Chou-Talaylay combination index (CI), was observed in all 8 cell lines. Treatment with a SIK2 inhibitor decreased the phosphorylation of class-IIa HDAC4/5/7, abolished class-IIa HDAC4/5/7-associated transcriptional activity of MEF2 and decreased MEF2 binding to regulatory regions with high-chromatin accessibility in DNA repair genes, resulting in repression of critical gene expression in DNA repair pathways. DNA damage, judged by rH2AX expression was enhanced by SIK2 inhibition. These observations not only provide new insights into the transcriptional regulation of DNA repair gene expression, but also have important implications for enhancing sensitivity of high grade serous ovarian cancers to PARP inhibition, with or without BRCA1 or BRCA2 germline mutations. Citation Format: Zhen Lu, Wequn Mao, Lan Pang, Janice M. Santiago-O9Farrill, Haling Yang, Ahmed Ahmed, Hariprasad Vankayalapati, Robert C. Bast. SIK2 inhibitors regulate DNA repair pathway and sensitize ovarian cancer to PARP1 inhibitors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 324.


From the Publisher:

Presents many computer-based problems that can be done in conjunction with a course in DSP theory.

Projects relate to practical systems and implementations so the reader can learn and understand how DSP is applied.

Includes projects and exercises, which make full use of the power of MATLAB v5 to explore conceptual, analytical, and computational issues in digital signal processing.
Many projects provide hints to introduce pitfalls, limitations and tricks for getting the most out of MATLAB v5.
Discusses both the power and limitations of MATLAB v5 functions and regularly explores the issue of using built-in functions versus developing code to solve problems.
Exercises consistently reinforce important problem solving behaviors, such as verifying results, experimenting with parameters as a means of building understanding and intuition, exploring the realism of formulations, comparing theoretical and numerical or measured results, and developing predictions and then comparing them to actual results.


The 31 Indonesian members of the genus Saprosites REDTENBACHER are revised, including four species described as new: Saprosites mahavus n. sp. from Sulawesi, S. matangi n. sp. and S. penrisseni n. sp. from Borneo, and S. pahangensis n. sp. from Malay Peninsula. Lectotypes and paralectotypes are here designated for four species: Saprosites coelebicus PAULIAN, S. fruhstorferi PAULIAN, S. implicatus SCHMIDT and S. verecundus SCHMIDT. Seven new specific synonyms are proposed: Saprosites coelebicus PAULIAN (= S. jacobsoni PAULIAN, syn. n.), S. implicatus SCHMIDT (= S. sumatranus PETROVITZ syn. n.), S. japonicus WATERHOUSE (= S. imperfuscus SCHMIDT syn. n. and S. coomani PAULIAN syn. n.), S. mjoebergi GILLET (= S. fruhstorferi PAULIAN syn. n.), S. narae LEWIS (= S. tonkinensis BALTHASAR syn. n.), S. verecundus SCHMIDT (= S. malaisei PAULIAN syn. n.). A general diagnosis of the genus is associated with a key for identification based on principal morphological characters of 31 species. Habitus and male genitalia of several species are illustrated.


IDS systems surge as telecommunication technology advances as do attacks on different networks, given that information has become a substantial asset in organizations and businesses, anyone connected to the Internet network is exposed to having their data collected for malicious purposes without an adequate protection system or tool, generally the information safeguard is limited to the use of antivirus and firewall although these help, they will not always be defending since some attacks and virus are out of their reach, and it is there where to select, implement and configure an IDS to contribute to the protection of information becomes necessary for those who want to add a plus to their network.
The present titulation work is oriented to the implementation and configuration of a open source tool for the detection of intruders in a Wi-Fi network. A Literature Systematic Review was carried out using the methodology of Barbara A. Kitchenham, getting relevant data such as advantages, disadvantages, characteristics and common attacks detected by an IDS, concluding that the most common attacks in a WIFI network are: network scan, denial of service (DoS) and man in the middle (MiTM).
A virtual testing environment was elaborated in which the design of the network (Wlan), hardware and software was established, where the tool was implemented and configured, making use of monitoring by signature detection and activating the use of an additional defense such as Suricata-update, a recently integrated option in order to optimize the process of downloading and updating the rules with which the IDS worked.
The IDS engine was subjected to three attacks using kali linux operating system tools (Nmap, Metasploit and Ettercap), thus checking the functioning of the intrusion detection system by identifying the alerts issued by each threat in the network.


Because the harmonic disturbance characteristic which makes voltage drop and the deterioration of instantaneous power quality in electrical power system overheats the NGR and the customer capacitor and malfunctions the OCGR and AMR, it is necessary for electric power company to take active measures to reduce this disturbance. International Electrotechnical Commission(IEC) 61000-3-2 specifies limits for harmonic current emissions generated by low voltage(LV) electrical equipment whose input current 16(A) per phase. Analysis shows that limits for Class A equipment in IEC are calculated using the reference impedance of LV system and maximum permissible voltage and limits for other Classes are also calculated based on limits for Class A. Therefore we have calculated four(4) internal limits for LV electrical equipment using the korea reference impedance and maximum permissible voltage in this paper.


Method of information integration based on ontology is put forward,to explode different type multi-information integration among war field space. On the base of plant information and survival information,it is first time to put forward to make use of ontology to describe information integration about different type multi-information. This is an interesting method to research farther integration command and control system.


Author(s): Jootar, Jittra | Abstract: This dissertation focuses on the effect of noisy channel estimates on the performance of finite-depth convolutionally coded system with different types of transmit diversity algorithms. Three transmit diversity algorithms analyzed are no transmit diversity, the Alamouti space-time code and the closed-loop transmit diversity. The dissertation begins with the derivation of the theoretical pairwise error probability of a finite-depth convolutionally coded system without transmit diversity assuming that channel estimates are calculated by an FIR filter from noisy channel estimates. With the assumptions that an FIR filter is used as the channel estimator and the interleaving depth is finite, the estimation-diversity tradeoff resulting from the effects of the Doppler spread on the system performance via the channel estimation accuracy and the channel diversity can be investigated. In addition, this section also verifies that, in the limit when the channel estimates are perfect, the result presented in this dissertation is the same as the well-known result derived from a different mathematical approach. To verify the analysis, the analytical results are compared with results from Monte Carlo simulation and the comparison shows that the analytical results match well with the simulation results. The dissertation continues with the analysis of the Alamouti space-time code with and without convolutional codes in time-varying fading channels also assuming that channel estimates are noisy. Two types of receivers are investigated for the conventional Alamouti space-time code without convolutional codes, namely, the linear-combining space-time decoder (LC-STD) and the maximum-likelihood space-time decoder (ML-STD). Two types of receivers are investigated for the concatenated system, namely, the LC-STD with the ML convolutional decoder and the joint Alamouti and convolutional ML decoder. The results have shown that the LC-STD is more sensitive to the Doppler spread than the ML-STD. However, since the ML- STD is very sensitive to the channel estimation error, the gains provided by the decoder in fast fading channels will be offset unless an optimized channel estimator is employed. Performance comparisons between the Alamouti systems and the SISO systems indicate that, when the system environment is not ideal, the SISO systems may outperform the Alamouti systems. A comparison between the analytical results and the simulation results shows that the analysis can predict the simulation results accurately. Finally, the closed-loop transmit diversity analyses are presented. The closed-form expressions for the uncoded bit error probability of closed-loop transmit diversity algorithms with two transmit antennas and noisy channel estimates in time- varying Rayleigh fading channels are derived. Two closed- loop transmit diversity algorithms considered are the phase-amplitude closed-loop transmit diversity (PA-CLTD), where the transmit antennas may transmit with different signal energy, and the phase-only closed-loop transmit diversity (PO-CLTD), where the transmit antennas must transmit with the same signal energy. The results have shown that PA-CLTD performs slightly better than PO-CLTD although PA-CLTD requires significantly more feedback information. Moreover, a comparison between PA-CLTD, the Alamouti space-time code and the SISO system indicates that PA-CLTD outperforms the other two systems when the Doppler spread is small and the pilot SNR is large. In addition to the uncoded bit error probability, this dissertation also derives the pairwise error probability when finite-depth interleaved convolutional codes are used with the closed-loop transmit diversity algorithms with two transmit antennas and noisy channel estimates in time- varying Rayleigh fading channels are derived. Two closed- loop transmit diversity algorithms considered are the phase-amplitude closed-loop transmit diversity (PA-CLTD), where the transmit antennas may transmit with different signal energy, and the phase-only closed-loop transmit diversity (PO-CLTD), where the transmit antennas must transmit with the same signal energy. The results have shown that PA-CLTD performs slightly better than PO-CLTD although PA-CLTD requires significantly more feedback information. Moreover, a comparison between PA-CLTD, the Alamouti space-time code and the SISO system indicates that PA-CLTD outperforms the other two systems when the Doppler spread is small and the pilot SNR is large. In addition to the uncoded bit error probability, this dissertation also derives the pairwise error probability when finite-depth interleaved convolutional codes are used with the closed-loop transmit diversity algorithms. The analytical results show that, when the Doppler spread is large, the performance of the closed-loop transmit diversity may degrade significantly. Finally, the analytical results are compared with results from Monte Carlo simulation and the comparison shows that the analytical results match well with the simulation results. This work was done at UCSD's California Institute for Telecommunications and Information Technology (CalIT2), under the Core Grant No. 02-10109 sponsored by Ericsson and the U.S. Army Research Office under the Multi University Initiative (MURI) grant No. W911NF-04-1-0224


There are two qualitatively different types of solution to the Josephson barrier equations. The first type corresponds to vortex lines in the barriers. For small damping, a rather complete picture of vortex line motion can be obtained including inertial and dissipative effects. The second type of solution corresponds to plasma oscillations. The stability of the solutions is investigated and results are obtained for the collective modes of the vortex lines and the propagation of plasma oscillations in a magnetic field.


The article pays attention of middle school teachers to the role of school physics and mathematics courses in qualitative education of future physicians. The purpose of this article is illustration of basic knowledge importance of the mathematics and physics disciplines for the natural sciences studying, in special, of medical and biological physics by students of medicine and dentistry faculties, biological physics and physical methods of analysis, higher mathematics and statistics by students in pharmacy, industrial pharmacy in pharmacy faculty and to specify the scope of these disciplines knowledge practical application. For studying of physics and mathematics importance for obtaining a medical education are used the following methods: theoretical – analysis of scientific publications on this issue; studying the order of the Ministry of Education and Science regarding to the conditions for admission to study at higher education establishment of Ukraine in 2019; practical analysis of background knowledge control results of first-year students in physics and mathematics. The conducted research revealed the presence of a big number of students with a low basic level of knowledge in physics and mathematics that complicates the understanding and assimilation of their courses at the medical university. The importance of knowledge in physics and mathematics for the practical medicine is shown. It is emphasized that the medicine achievements are linked to the scientific achievements of physics and techniques development. Thus, the motivation for successful mastering of physics and mathematics is formed for the students who choose medical education.


Lectin concept defines a class of proteins or glycoproteins with agglutinating properties on other cells that can reversibly bind carbohydrates without altering their structure. The aim of the present study was to investigate the influence of geographical area of production on lectin of banana. The lectin content, after isolation and purification was evaluated by hemagglutination tests. It was observed that the haemagglutinating activity is different between bananas from different sources.The results suggest that these laboratory determinations can identify the source of origin of the bananas. Introduction Lectins are ubiquitous, their isolation is possible from almost any living organisms, including plants, alga, fungus, microorganisms such as bacteria, viruses, invertebrates and vertebrates (Sharon and Lis, 2007). Lectins exihibit a wide range of biological roles, including mediation of cellular and molecular recognition, resulting in immunomodulation, hormone-like, antitumor, antiviral or metabolic activities (Varki et al., 1999).


This paper presents the dynamic performance enhancement of a wind farm connected to an IEEE-39 bus New England test system using doubly-fed induction machine (DFIM)-based flywheel energy storage system (FESS). The variable wind speed causes fluctuations in the output power of the wind farms. The use of FESS smoothes the power of the wind farm and improves the dynamic response of the system during fluctuating wind speeds. A DFIM-based FESS is proposed in this study which works on an effective control technique. The cascaded black-box optimization technique based proportional-integral (PI) control strategy is implemented on the FESS. The PI controllers are used to control the insulated gate bipolar transistor (IGBT) based rotor side converter (RSC) and the grid side converter (GSC) of the DFIM. The PI controller In-depth modeling and control strategy of the system under study is presented. The effectiveness of the proposed system is tested under real-time wind speed data. The validity of the system is verified by the simulation results which are carried out using PSCAD/EMTDC.


Neurofibromatosis type 1 (NF1) is a relatively common genetic disease that is associated with a variety of neurologic complications. In addition to irregularities such as the formation of neurofibromas and neurofibrosarcomas, NF1 patients also suffer increased incidence of chronic pain ([Creange et


The worldwide contamination of food and feed with mycotoxins is a significant problem. Aflatoxins are major mycotoxins of agro-economic importance produced by some Aspergillus species. Aflatoxigenic Aspergillus species were isolated from insect larvae damaged maize stalks and characterized. The fungi were isolated from the stems, ears and silks of the plant. Aflatoxin production by the isolates was determined using the ammonium hydroxide method as well as the ultra violet fluorescence method. The Lepidopteran species feeding on the crop was identified as Busseola fusca. The Aspergillus species isolated were identified as Aspergillus flavus and Aspergillus parasiticus. This was done using macroand microscopic features. A total of 35 isolates were obtained of which only 17 were aflatoxigenic. From the aflatoxigenic species 88% were A. parasiticus whilst 12% were A. flavus. Insects were however negative for aflatoxigenic fungi implying that these insects do not act as direct vectors of aflatoxigenic fungi, but however predispose the crop to fungal infection by damaging the physical barrier.


When observed by the MODIS sensor, the mean radiative power of boreal forest fires in Siberia, compared with fires in North America, appears significantly lower. Here we explore possible reasons for this difference and we find that it is not a result of orbital parameters, detector effects or cross track illumination differences, but the effect appears to be due to a physical difference between the forests. The result agrees with independent modeling work assessing the plant functional types in each region, and their life cycle adaptation with respect to fire. We go on to analyse the variation of fire radiative power with latitude and time with respect to the fire diurnal cycle. Finally, we examine the relationship between fire radiative power and burnt area and demonstrate the development of "delayed" fire scars in Siberia, as a consequence of post-fire dieback after lower intensity fires.


Objective To establish the 280 nm quantitative HPLC fingerprints of Salviae miltiorrhizae Radix Et Rhizoma and determine its antioxidant activity,between which the bivariate correlation analysis was performed.Methods The fingerprints of Salviae miltiorrhizae Radix Et Rhizoma were established by HPLC method and evaluated by the systematically quantified fingerprint method(SQFM).Meanwhile the cleaning ratio(CLR) of hydroxyl free radical were also determined and the bivariate correlation analysis was employed to investigate the conjunction between each fingerprint and the CLR calculated by SPSS 16.0 software.Results S9 was the most antioxidant activity within the 10 batches of samples,and the correlation analysis showed that 18 fingerprint peaks(2,3,9,10,11,14,16,18,19,21,23,24,29,31,32,34,35,and 43) were positively correlated with the anti-oxidation activity significantly among the 44 common chromatographic peaks in the 280 nm HPLC fingerprints.Conclusion The antioxidant profile relationship between the HPLC fingerprint peaks and the CLR has been established,which may serve as a reference for screening the antioxidant active ingredients to better control the quality of Salviae miltiorrhizae Radix Et Rhizoma.


The purpose of this paper is to explore the influence of ICT on construction supply chain management (CSCM). Furthermore, this research proposes a model for ICT that can be used to test and improve CSCM within the Nigerian construction industry. The relationship between ICT and CSCM was highlighted in an integrated model. Structural equation modelling (SEM) was used to validate the hypothesised relationship by evaluating the responses of practitioners working in construction project management related firms using a sample of 214 respondents. The findings of this study show a link between ICT and CSCM on five (5) of the constructs on targeted construction firms engaged in supply chain (SC)-related construction activities in Port-Harcourt, Rivers State, Nigeria. This research is supported by the Technology Organisation and Environment (TOE) Model as a key theory of technology adoption. With an average R2 value, the SEM model is 76%, which is commendable (high). The current study offers an empirical and theoretical explanation of various aspects of ICT and CSCM, particularly in the Nigerian construction industry. As a result, this study adds to the body of knowledge by providing crucial insight into the influence of ICT on CSCM throughout the entire construction supply chain. The knowledge gained will aid industry stakeholders and the government in developing policies that will increase ICT adoption in current practice.


The authors have been carrying out research and development of a laminated polarizer (LAMIPOL) as a polarizer suitable of integration. In this paper, with a view to obtain a high-performance LAMIPOL over a broad, shorter wavelength region (0.6 μm < λ < 1 μm), a LAMIPOL with an ultrathin germanium thin film (20 to 80 A) was designed and fabricated. As a result, high performance as designed was realized in the wavelength region of 0.6 μm < λ < 1 μm. However, as the Ge laminated layer is made even thinner (such as 20 A or 30 A), the computed and measured values for the attenuation constant αTM for the TM wave do not agree and the cause was studied.

First, from the experimental results for various Ge thin films, it was found that the nature of the boundary layer does not depend on the lamination thickness of the Ge layer. Further, the model with a boundary layer having a uniform relative permittivity (step approximation) and the model with continuously varying permittivity (linear approximation) were considered. With the latter, it was possible to compute accurately the characteristics of the LAMIPOL for the TM wave if the Ge laminated layer thickness is more than 30 A.


A X-band electronically scanned active phased array antenna has been developed for an airborne SAR/MTI radar, with an European team from France, Germany, Italy, Netherlands and Spain. RF simulations and re-use or adaptation of available elements have made it possible to design and develop in a reduced time frame the different constitutive parts of the antenna assembly. In the integration process, the radiating unit has undergone a calibration process in a near field test range. Radiation patterns for the various modes, in the frequency band and within the angular field-of-view have been obtained through near-field to far-field transform, and the antenna assembly radiated power (EIRP) and quality factor (G/T) has been evaluated with a near-field procedures.


Based on the basic theory of deep hole surveying and the engineering practices,this paper generalized the typical abnormal deep hole displacement monitoring curve from large amount of engineering examples about deep hole displacement monitoring on slope,and further analyzed the causes of the abnormals and the corrective measures. In relation to the key steps affecting the monitoring result,including hole arrangement,drilling,acquisition and processing of the monitoring data,definite control requirements were proposed to ensure the accuracy and reliability of the monitoring.


This work focuses on the way Italian informants of different ages (4, 7, and 10 year old children and adults) build discourse cohesion and thematic coherence with respect to two different narrative tasks. The data was collected using the video clip The Finite Story (Dimroth, 2006) and a sequence of 30 pictures composing a story (created by C. Dimroth as well). The characteristic of these two tasks is to involve a non prototypical flux of information since the episodes to retell force speakers to continually contrast entities, time spans and positive or negative polarities, besides of course maintaining or reintroducing the reference to some of the preceding referential domains. These tasks should force speakers to employ anaphoric means such as additive particles, temporal adverbs, polarity markings and prosodic strategies etc. This work will essentially explore three subjects: a. the cognitive processes guiding Italian children's narrations
at the different ages considered here, and consequently the different comprehension they have of the tasks proposed; b. the linguistic means children use to make the text cohesive; c. the influence of the typological specificities of Italian language on points (a) and (b). The results will be compared, as far as the available studies make it possible, to the ones relative to children of the same age learning German, Polish and French.


The effect of interlayer distance of nanoclay on mechanical properties, cure characteristics, and swelling resistance of natural rubber (NR) in varying clay proportion were studied. X-ray diffraction results of nanocomposite with 10 phr of nanoclay showed the formation of an intercalated structure. The rate of vulcanization and maximum torque value of the nanocomposite are higher than the gum compound. Nanocomposites with clay having higher interlayer distance shows superior mechanical properties. Mechanical properties gradually increase with increase in clay loading up to 10 phr. A 50% increase in tensile strength and about 150% increase in modulus at 300% elongation were observed for the nanocomposite with 10 phr clay loading. Better barrier properties offered by the nanocomposites due to the presence of tortous path was confirmed by the Nielson's model.


Introduction: Brachytherapy, especially using manually after loaded Iridium-192 and Cobalt-60, can be applied as a sole treatment, as a treatment complementary to surgery, and as a local boost in combination with EBRT. The use of HDR brachytherapy catheters incorporated in removable dental molds allows repeated, highly reproducible, fractionated outpatient brachytherapy of superficial tumors without requiring repeated catheter insertion into the tumor. One of the important use of molds is controlling hyper dose sleeves. Some suitable sites for mould therapy include the scalp, lip, buccal mucosa and hard palate. In this study, we are going to dosimetry this lips mould with TLD-100 and comparing with Plexiglass exclusive phantom results.
Materials and Methods: This study has done for an early stage lip squamous cell carcinoma with mold and an exclusive lips phantom that were definitively done with using HDR brachytherapy. A customized mold was fabricated for a patient with lips superficial tumor and TLD-100 were located in the surface of mold and phantom, in which 3-4 after loading catheters were placed for passing the Iridium and Cobalt sources.

Results: The results show that we have difference about 2 percent between dose calculation for mold and phantom for Iridium and about 1.5 percent for Cobalt.
Conclusion: HDR brachytherapy using the mold technique as definitive treatment or for boosting the dose after radiotherapy, is a safe and excellent method for selected early and superficial lip cancers.


We show that the $n$-point correlation function for the fractional parts of a random linear form in $m$ variables has a limit distribution with power-like tail. The existence of the limit distribution follows from the mixing property of flows on ${\rm SL}(m+1,{\Bbb R})/{\rm SL}(m+1,{\Bbb Z})$. Moreover, we prove similar limit theorems (i) for the probability to find the fractional part of a random linear form close to zero and (ii) also for related trigonometric sums. For large $m$, all of the above limit distributions approach the classical distributions for independent uniformly distributed random variables.


Designing an effective criterion for selecting the best rule is a major problem in the process of implementing Fuzzy Learning Classifier (FLC) systems. Conventionally confidence and support or combined measures of these are used as criteria for fuzzy rule evaluation. In this paper new entities namely precision and recall from the field of Information Retrieval (IR) systems is adapted as alternative criteria for fuzzy rule evaluation. Several different combinations of precision and recall are redesigned to produce a metric measure. These newly introduced criteria are utilized as a rule selection mechanism in the method of Iterative Rule Learning (IRL) of FLC. In several experiments, three standard datasets are used to compare and contrast the novel IR based criteria with other previously developed measures. Experimental results illustrate the effectiveness of the proposed techniques in terms of classification performance and computational efficiency.


If the industry-transferred universities want to get rid of the plight of external environment and their own development,they must deal with the relationships between keeping industry characteristics and blending into local economical and social development.By analyzing the practice of Wuhan Textile University,this article finds that the change of source-getting methods affects the universities' behaviors and the universities can realize its endurable development if they are able to establish their characteristic developing strategies according to the changing environments.


The utility model discloses a road lamp heat abstractor, which comprises an outer casing, an aluminum-based PCB plate and an illuminating element which is welded on the aluminum-based PCB plate, wherein a plurality of radiators are arranged in the outer casing, the upper portions of axial lateral ends of the radiators are provided with inversed grooves, and the lower portions are provided with clamping channels, and the lower portions of another axial lateral ends are provided with raised clamping poles, the adjacent radiators are clamped and embedded in the clamping channels through the raised clamping poles and radiating fins are clamped and embedded in the reversed grooves to be connected together. Compared with the prior art, the utility model adopts a plurality of radiators which are the same and are connected together in a camping and embedding way, the upper surfaces of thermal conducting substrates on the radiators are radiating fins, the lower surfaces are clung to the aluminum-based PCB plate to absorb heat which is produced by the LED which emits light, and the heat is transferred to the radiating fins through the thermal conducting substrates. The designs of the radiators of the utility model are unique, the conception is novel, the combing mode between the same radiators is not only simple and compact, but also the combing mode largely reduces production cost.


the Index of Care: A Web based Application Supporting Archaeological Research into Health-related Care. International Journal of Paleopathology, 6: 5–9. doi: https://doi.org/10.1016/j.ijpp. 2014.01.003 Tilley, L. & Oxenham, M.F. 2011. Survival Against the Odds: Modeling the Social Implications of Care Provision to Seriously Disabled Individuals. International Journal of Paleopathology, 1: 35–42. doi: https://doi.org/10.1016/j.ijpp. 2011.02.003


The model of harmonic ascillator was built, which atoms in crystal of inert gas interact with each other. According to quantum theory, it calculated interactive energy, and discussed its characters. Finally, the conclusion is gotten that atoms′ interaction is added by the gravity of R -6 of two oscillators′ distance (R) and repulsion of R -12.


Articular chondrocytes in vivo are exposed to a changing osmotic environment under both physiological (static load) and pathological (osteoarthritis) conditions. Such changes to matrix hydration could alter cell volume in situ and influence matrix metabolism. However the ability of chondrocytes to regulate their volume in the face of osmotic perturbations have not been studied in detail. We have investigated the regulatory volume decrease (RVD) capacity of bovine articular chondrocytes within, and isolated from the matrix, before and following acute hypotonic challenge. Cell volumes were determined by visualising fluorescently‐labelled chondrocytes using confocal laser scanning microscopy (CLSM) at 21°C. Chondrocytes in situ were grouped into superficial (SZ), mid (MZ), and deep zones (DZ). When exposed to 180mOsm or 250mOsm hypotonic challenge, cells in situ swelled rapidly (within ∼90 sec). Chondrocytes then exhibited rapid RVD (t1/2 ∼ 8 min), with cells from all zones returning to ∼3% of their initial volume after 20 min. There was no significant difference in the rates of RVD between chondrocytes in the three zones. Similarly, no difference in the rate of RVD was observed for an osmotic shock from 280 to 250 or 180mOsm. Chondrocytes isolated from the matrix into medium of 380mOsm and then exposed to 280mOsm showed an identical RVD response to that of in situ cells. The RVD response of in situ cells was inhibited by REV 5901. The results suggested that the signalling pathways involved in RVD remained intact after chondrocyte isolation from cartilage and thus it was likely that there was no role for cell‐matrix interactions in mediating RVD. © 2001 Wiley‐Liss, Inc.


A workshop was convened to assist DOE's Technology Assessment Division in evaluating the need to prepare additional environmental- and social-impact assessments of different energy-conservation measures. Attendees participated in a decision-making exercise designed to rank 19 different energy-conservation measures according to their overall potential for achieving important national goals and their ease of implementation. The participants felt that the most-important ranking criteria dealt with questions concerning feasibility (economic, political/institutional, social, and technical) and economic efficiency. Other criteria, such as environmental quality and occupational health and safety received lower weights; possibly because of the widespread belief that most of the conservation measures presented would be environmentally beneficial. In the participants' view, the most-promising and feasible conservation measures include new-building-performance standards, retrofit of existing housing stock, new-appliance-performance standards and increased use of smaller cars. In contrast, conservation options which ranked rather low, such as diesel engines, coal-fired aluminum remelt furnaces, and cupola furnace modifications were expected to have some harmful environmental and health impacts. Most of these impacts are expected to be highly localized and of lesser national concern. Disagreement exists as to the efficacy of funding those projects deemed highly desirable and feasible versus those which are expected to have the greatermore » environmental and social impacts. These differences must be taken into account in the research priorities that are eventually established. While environmental and social impacts of alternative energy-conservation measures may prove to be either harmful or beneficial, neither side should be ignored by the policy maker.« less


In 1953, S. Okamoto et al found that epsilone aminocaproic acid(l) (EACA) was an effective agent for inhibiting disorders of fibrinolytic activity in vitro and in vivo. Since then a number of studies were carried out either experimental ly or clinically. For the clinical need the exertion of discovering a far more potent inhibitor had been continued by the same authors, and in consequence in 1961 aminomethyl cyclohexane carboxylic acid (AMCHA) was found.(2) Methods of EACA assay were already published by Sjoerdsma and Hanson,l3' McNicol et al (4) and Mori et al.(5) But their methods were not so sensitive that they could not investigate the relation of EACA concentration to its anti fibrinolytic action. Assay technique of AMCHA has not yet been established. In this paper we report a method of quantitative analysis of EACA and AMCHA from the blood and tissues using column chromatography .


The paper introduces the B/S network structure of the web applying system and the basic middleware technique to realize web database system, and then develops the web-based database application using Java technique.


Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the pathologic accumulation of beta amyloid (Aβ), Tau and α‐synuclein (α‐syn). The role of α‐synuclein has been extensively studied in Parkinson's disease, but less so in AD. Recent studies have shown that α‐syn may also play a role in AD and its downregulation could be protective against the toxic effects of Aβ accumulation. First, we hypothesized that selectively knocking down α‐syn improves the neuropathological, biochemical, and cognitive findings in AD. Second, we tested whether α‐syn ablation could enhance AD treatments with donepezil (pro‐cholinergic) and memantine (glutamate antagonist), which are currently ineffective at slowing progression of disease.


The presentation of lymphatic tuberculosis in the pelvic area is relatively uncommon which makes diagnosis even more difficult especially in the context of cancer patients This case report demonstrate a patient with previous diagnosis of adenocarcinoma of the colon pT pN PMX who underwent rectosigmoidectomy A few months after the patient complained of weight loss and loss of appetite which led investigation of recurrence or metastasis In order to clarify the changes in clinical patient a CT Positron Emission has been requested which showed brightness of images in the pelvic region indicative of lymph node metastasis A pelvic lymphadenectomy was conducted showing a fibrofatty tissue exhibiting steatonecrosis fibrosis and mild inflammation foci with no atypical cells in the sample The tuberculin skin test was used with a strong result mm x mm confirming the diagnosis the patient was then treated with the RIPE scheme RIF INH PZA ethambutol resulting in improvement of the symptoms The differential diagnosis of abdominal lymphadenopathy in a patient after tumor resection involves examining the colon PET scans to assess the avidity of body tissues to capture positrons However it is known that PET scans and conventional CT scan detect changes resulting from malignancies such as lymphomas and tumor recurrences is able to show lymphadenopathy arising from lymphatic tuberculosis due to the presence of inflammatory cells In conclusion it should be considered that patients treated or follow diagnosed with cancer are more likely to tuberculosis than the normal population and therefore positive results of PET scans should be interpreted with caution in the differentiation of benign and malignant lesions especially in regions with high prevalence of tuberculosis and must be confirmed by pathological examination before the start of definitive treatment


The invention discloses a preposed measuring device for dynamically testing road illumination one-site. The preposed measuring device for dynamically testing road illumination one-site comprises a detecting system and a control system; the detecting system is movably arranged at the front end of an engineering inspection car; and the control system is arranged inside the engineering inspection car; the detecting system comprises a measuring rod and an illuminometer having a probe; the tail end of the measuring rod is connected with the front end of the engineering inspection car; the illuminometer is located on the front end of the measuring rod; an included angle between a connection line and the horizontal line is ranged from 0 degree to 29 degrees, wherein the connection line is between the probe of the illuminometer and the front top portion of the engineering inspection car; the height from the top of the probe of the illuminometer to the ground is less than or equal to 200 mm; the control system is connected with the illuminometer; the control system controls actions of the illuminometer, analyzes and processes data detected by the illuminometer. Thereby, dynamically testing road illumination on-site is more simple, convenient, objective, and precise.


This study investigated the application of pulse‐amplitude‐modulated (PAM) fluorometry as a rapid assessment of benthic macroalgal physiological status. Maximum quantum efficiency (Fv/Fm), dark–light induction curves, and rapid fluorescence light‐response curves (RLC) were measured on the filamentous macroalgal Cladophora sp. from Lake Ontario on 5 d at 16 sites spanning a gradient of light and nutrient supply. For Cladophora sp. growing in situ, light limitation was assessed by comparing average daily irradiance with the light utilization efficiency parameter (α) derived from RLCs. In this study, there was a nonlinear relationship between Fv/Fm and the degree of P limitation in macroalgae. However, only light‐saturated Cladophora sp. showed a significant positive linear relationship between Fv/Fm and P nutrient status. The absence of this relationship among light‐limited algae indicates that their photosynthetic rate would be stimulated by increased water clarity, and not by increased P supply. PAM fluorescence measures were successfully able to identify light‐saturated macroalgae and, among these, assess the degree to which they were nutrient limited. These results enable us to test hypotheses arising from numeric models predicting the impact of changes in light penetration and nutrient supply on benthic primary production.


As a special form of China's higher education, the state-owned community-run secondary-level college has displayed its vigor. The article conducts some analysis and investigation of the necessity of its appearance, the superiority of its existence and exploration of its development in terms of the relation between social economic development and higher education.


Physiological-ecological characteristics of mixture grassland of cultivated perennial grasses were studied in apline area of Qinghai-Tibetan plateau, Jingqianghe area of Tianzhu county. The results indicated that the ≥0 ℃ accumulated temperature and average daily temperature of 0~20 cm soil on the mixture grassland could be promoted 40.6 ℃~246.7 ℃ and 0.3 ℃~1.7 ℃ respectively, during growing season when compared with single grassland. The peak increment of highest ≥0 ℃ accumulated temperature and average daily temperature of surface soil on the mixture grassland occured in June, and that of 5 cm, 10 cm, 15 cm and 20 cm soil on the mixture grassland occurred in May. Solar conversion efficiency (SCE) of the mixture grassland was higher than that of corresponding single grassland (P0.05). The SCE of 4 grass species communities was higher than that of 2 and 3 grass species communities (P0.05),and the SCE of 3 grass species communities was not statistically different from that of 3 grass species communities (P0.05). Photosynthesis rate (Pr) and water utilization efficiency (WUE) of leaves were highly related to the grass species, not related to the sowing patterns, mixture or single.


The vegetation and wild life in Saint Catherine area is subjected to great disturbance through the unmanaged human activities. In the present study we had used seed ecology in order to contribute in designing a sound long term conservation plan for the two threatened endemic studied medicinal species; Plantagosinaica, and two other Plantago species; P. ovataand P. lagopus at three levels; (a) studying the germination response at different conditions and pretreatments on wetted substrate (b) the effect of moisture content percentage on the germination during different storage periods and (C) the effect of burying on seed longevity and viability. For the threePlantago species there was a great variation in the behavior of seed germination among them, we observed that sulphoric acid (H2SO4) was the only treatment that enhanced germination in the three species at least at one of the temperature treatments. The moisture isotherm of P. ovataand P. sinaicarevealed a positive correlation with germination and negative one with storage period, one can say that Plantagosinaica and Plantagoovata seeds are orthodox as it prefers low moisture and there was a negative correlation between germination and moisture content with a significant correlation coefficient (r = 0.622 and P= 0.006).The depth of buried seeds seem to be protective to an extent as the highest germination percentages after one year (80 and 91%) were that at 2 cm depth in the loamy and clay soil respectively.As a general conclusion, the present study clarified that the behavior of the three species along environmental gradients is similar to a great extent in storage behavior, but it differs in the germination behavior, as well as in the strategies in struggling for existence.


The present study was performed on a total of 104 recently dead chickens from Gharbia Governorate that inspected for Enterobacteriaceae from internal organs after clinical and postmortem examination. The results revealed that 95 samples were positive, Escherichia coli (53), where Salmonella.spp. (31) , Citrobacter freundii (14), Enterobacter cloacae (6), Klebsiella oxytoca (5) , Proteus vulgaris (4) , Acinetobacter lowoffii , Edwardsiella tarda respectively, and Enterobacter gergoviae , Enterobacter pantoe (2) respectively . Amikacin and gentamicin were the highest efficiency antimicrobial agents used in vitro with variation in sensitivity to others except Proteus vulgaris was resist to all . Seven E.coli isolates were serotyped and identified as O 1 , O 6 , O 125 and O 146 . PCR results for E.coli showed that tsp E4c2 and yja A pathotypic genes( at 152 bp and 211 bp) were detected in all, but only O 125 and O 146 have chu A gene ( at 279 bp). While hly A (at 450 bp) was detected in O 6 , eae A (at 248bp) and stx 1(at 614 bp) gene was detected in 1 strain of (O 125 ), iss gene (at 323 bp) was detected in another isolate of O 125 and stx 2 (at 779 bp) was absent in all. All that indicate that E. coli strains isolated were extra-intestinal pathogenic strains. PCR results for 5studied K. oxytoca strains showed that all of them leak iro N ,but all have peh X gene.


This thesis investigates the electron-phonon interactions in fabricated Semiconductor Devices i.e. Schottky Diodes, Quantum Well (QW) embedded p-i-n photodiodes, two dimensional electron gas (2DEG) and two-dimensional hole gas (2DHG) structures all on (311) GaAs substrates. Fast electrical measurements were performed on Schottky diodes fabricated on the (311B) GaAs surface. Optical excitation generates a compressive strain pulse in an Al film which is at the opposite side of the GaAs substrate. Two coherent acoustic phonon modes were generated in the (311B) GaAs substrate: quasi-longitudinal phonons (QLA) and quasi-transverse phonons (QTA). These two modes were detected successfully using the Schottky diode, the dependence of QLA and QTA signals on different applied bias, pump powers and temperatures were investigated.

The dependence of signals on bias reveals that the temporal position of the signals for QLA and QTA moves slightly earlier times with increasing reverse bias because the width of the depletion layer increases with increasing negative bias. The first peak arrival time for QLA phonons in the measured signal moves to earlier times with increasing pump power. This was caused by the nonlinear acoustic properties of the GaAs substrate. Conversely, QTA phonons arrival time was not dependent on pump power which indicates the elastic nonlinear effects are not crucial for QTA signals. Investigation of the temperature dependence reveals that the arrival time changes to later times with increasing temperature because of the decreasing sound velocity with increasing temperature.

The polarity of the experimental signals was compared to the simulated signals of electron-phonon coupling interactions concludes the predominant role of piezoelectric phonon-electric transformation mechanism over deformation potential. Detailed theoretical calculations show the dominance of the piezoelectric mechanism up to frequencies of 70GHz and 250GHz for longitudinal and transverse phonons respectively.

Low dimensional structures i.e. Quantum well embedded p-i-n photodiode detector (QW-p-i-n), two-dimensional electron gas (2DEG) and two-dimensional hole gas (2DHG), fabricated on the (311) GaAs surface, were also investigated as detectors for longitudinal and transverse acoustic signals. The first experimental evidence of high frequency tail in transverse signal is observed using GaAs based QW-p-i-n detector. The longitudinal signal confirms the existence of the GHz oscillations, with the most significant occurring 170 GHz, while in transverse acoustic signal we observed a high frequency tail from 300 ps to 800 ps. Fast Fourier transforms (FFT) analysis of this tail shows the existence of high frequency phonons up to 200 GHz. Photocurrent pump-probe measurements was also performed with three different Al film thicknesses (20nm, 30nm and 100nm). Experiments performed with 20nm film thickness clearly shows a weak signal at 250 GHz in the amplitude spectrum which is not observed for 30 nm and 100 nm aluminium films. This observation indicates that the thinner aluminium films can generate higher frequency phonons. The longitudinal and transverse signals were also detected by the 2DHG; for QLA predominantly the peak is negative while for QTA it is positive in contrast to the 2DEG experiments due to the reason that in 2DEG experiments the origin of the signal is due to the decrease in carrier density but for 2DHG the signal is due to the increase in carrier density.

This thesis studies the interaction of subterahertz acoustic phonons with charge carriers with the aim of developing high speed acoustoelectric detectors for subterahertz compressional and shear acoustic waves, and it has been shown that the Schottky diodes are successful in this application.


Conversation serves an effective way of character depiction,which is a central task of novel writing.It can reveal important information about the character,for example,its personality,background and psychological state,making the character more vivid and true to life,and thus it deserves special attention in the translation process.Comparing three Chinese versions of Pride and Prejudice,this article tries to demonstrate the importance of conversation in character rendering,and propose things to consider in conversation translation.


Objective: The purpose of this study is to compare the effects of Dong-si acupuncture therapy and General acupuncture therapy for the patients with acute ankle sprain. Methods : This study has been carried out for 60 cases of ankle sprain patients who have visited Dong-Seo Oriental medical Hospital from May 1, 2002 to September 30, 2002. We have treated 30 cases of them by Dong-si acupuncture therapy and the other 30 cases by General acupuncture therapy. And we have compared those two group. Results : 1. There was no significant difference at the treatment period and the number of treatment times in comparing two groups. 2. The number of treatment times for good effect is that : Dong-si took 1.57±0.85 times and General acupuncture therapy took 2.15±0.96 times. And we have found that the effect of Dong-si acupuncture therapy is faster than the other.


In this paper, effects of heat transfer on the blood flow through a stenosed, inclined non-tapered porous artery subject to the action of external magnetic field is investigated. Viscosity is assumed as variable viscosity with variable Hematocrit throughout the region of the artery. Governing equations have been modeled by taking blood as incompressible magnetohydrodynamic (MHD) Newtonian fluid. The energy equation is formulated by taking an extra factor of the heat source in its equation. The nonlinear momentum equations are simplified under the assumption of mild stenosis. Homotopy perturbation method (HPM) is used to solve nonlinear equations of velocity and temperature profiles. Effects of porosity parameter (Z), applied magnetic field parameter (M), variable hematocrit parameter(Hr), Brinkman number (Br), heat source parameter (Q) and the Grashof number (Gr) on velocity and temperature profiles are discussed graphically.


The cryogenic performance of a 200 GHz SiGe HBT technology is presented for the first time. Measurements of the current-voltage, small-signal ac, and broadband noise characteristics of a 200 GHz SiGe HBT was made at 85K, 150K, 200K and 300K. At 85K, these SiGe HBTs maintain excellent dc ideality, with a peak current gain of 3800, a peak cut-off frequency of 250 GHz, and a minimum noise figure of approximately 0.30 dB at a frequency of 14 GHz, and in all cases represent improvements over their corresponding 300K values. These results suggest that aggressively-scaled SiGe HBT technology is well-suited for emerging cryogenic applications requiring extreme levels of transistor performance.


Religiosity is typically related to positive outcomes following distress, yet it remains unclear how religiosity may alter responses when one's religious identity itself is challenged. The present investigation examined the role of appraisal-coping processes in the relations between religious orientations, emotions, and action intentions following identity threat. Study 1 (N 63) assessed associations with religious orientations (intrinsic and extrinsic) following a threat targeting one's religion. Although both orientations evoked a broad array of responses, those related to an intrinsic orientation were stronger and included more negative reactions (e.g., sadness, confrontation). Study 2 (N 59) evaluated the impact of a nonreligious identity threat, which elicited only adaptive responses (i.e., problemfocused coping, support seeking) that were associated with an intrinsic orientation. Appraisal-coping processes mediated relations between religiosity and responses to an identity threat in both studies but were most evident following religious threat. Taken together, these findings suggest that whereas an extrinsic religious orientation may function as a social identity in response to religious threats, the positive effects of an intrinsic religious orientation appear to be undermined by threats targeting the social group and belief system therein.


Cell-Free Massive MIMO is a distributed Massive MIMO network, consisting of many low-cost, low-energy access points (APs) connected to a Central Control Unit (CCU) via a backhaul network. The number of AP antennas far surpasses the number of users. In CFmM, the network is not divided into cells, and all APs cover all users. Although distributing the APs enhances network coverage and efficiency, it significantly increases the backhaul network load which is a drawback for future networks and the emerging C-RAN with limited backhaul capacity. In this paper, we propose centralized and distributed sub carrier-based zero-forcing (ZF) precoding solutions and compute the downlink rate for the proposed systems. The centralized solution resolves the need for using multiple antennas per AP whereas, the distributed version is a suitable candidate to reduce the backhaul load.


I never thought hewould survive.Mike, a formermajor-leaguebaseball umpire, lay dying in the intensive care unit following a heart transplant for end-stage heart disease. While initially stable, he had developed multiple problemswith both transplant rejection and sepsis. Intubated and on a ventilator, he was surrounded by a forest of IV polls that poured various vasoactive compounds into him in a desperate attempt to save his life. As days went by, his condition continued to worsen and hope for his recovery faded. Eventually, it seemed as if all hopewas lost and the family was called in to say goodbye. His wife and 7-year-old granddaughter entered the room. Mike's daughter had died of breast cancer the previous year, and he and his wife had taken in her child to raise as their own. At this point, Mike's blood pressure and oxygen levels were dangerously low and his heart rate was significantly elevated. Mike's wife sat distraught in a chair next to his bed, saying little and looking helpless. However, his granddaughter went directly to his bedside and proceeded to wrap her tiny hands around Mike's. "Grandpa," she said, "don't leave me, don't leave me Grandpa, I need you." With that she began to cry. But at that moment something remarkable began to happen. Mike's blood pressure and oxygen levels began to rise and his heart rate lowered. I stood watching in astonishment. The whole time she was touching him his blood pressure and heart rate became stable. The moment she let go of him Mike's blood pressure and heart rate would slowly drift back to their former critical levels. Intrigued by the effect that the child's touch had onMike, I asked if his wife and granddaughter could return the next day. They did, and when the child touched him Mike's blood pressure, oxygen levels, and heart rate would improve only to worsen after she left. I asked Mike's wife if she could bring the child to the intensive care unit each day for as long as possible. She agreed. The nursing director of the intensive care unit initially objected to having a child in Mike's room each day, but changed her mind when she saw the effect the child had on his vital signs. "It's a miracle," she muttered under her breath and quickly left the room. Thereafter, day by day, little by little, in what was an astonishing recovery from the very brink of death, Mike slowly improved. Eventually, his breathing tube was removed and he could once again speak and move. He hugged his granddaughter tightly and in a voice as soft as a whisper said, "I knew you were there, Mary, I knew it was you." I watched in astonishment and cried. Gradually, Mike improved enough to be sent to a rehabilitation center and ultimately home, always with his granddaughter by his side gently holding his hand, a testament to the tremendous power of touch. He has thrived ever since. In a world where direct connections between people are becoming increasingly rare, and are in danger of becoming lost altogether, we've forgotten the significant healing power of human touch. Numerous studies have demonstrated that humans are born with an inherent ability to perceive and interpret the touch of another. Touch appears to be an inherent part of what makes us human, and in its absence we decline, particularly when confronted by illness. In the late 1800s and early 1900s, sick infants were admitted to the hospital and placed into the then newly developed devices called "incubators." Once placed inside, the child was effectively cut off from the outside world and kept in a "clean" and germ-free environment. Contact with all people (even the child'smother) was discouraged and kept to an absolute minimum so as to lessen the infant's exposure to infection, thereby enhancing their health and ensuring their recovery. Yet, the exact opposite effect occurred; the children literally wasted way, with markedly diminished physical growth, along with retarded language andmotor skills development. All too often these childrenwould decline into a slowandpainful death.Only years laterwas it discovered that the cause of their dramatic decline in health was the lack of physical contact between the infants and their parents and caregivers. Years later, the collapse of communism in Eastern Europe revealed the appalling condition of many orphanages and residential nurseries there. Children in these facilities were given an absolute minimum of physical contact throughout their lives. Again, the resultswere a significant disruption in language, social, and neuromuscular development that would often persist into adult life. Death rates of children in these facilities were notoriously high. In stark contrast, the dramatic healing power of touch was demonstrated in Worcester, Massachusetts, in 1995. There a pair of twin girls was delivered 12 weeks prematurely, with each weighing only 2 pounds. While initially stable, at 3 weeks of age one of the pair began to markedly decline. The one infant struggled to breathe with her blood pressure and oxygen levels plummeting, while her heart rate soared. Acting on a hunch, the nurse caring for the frail child placed the stronger and more stable of the two twins together in the incubator with the weaker one. After a few moments, the stronger twin reached out her arm and placed it over her struggling sister. Within moments the weaker one's blood pressure, heart rate, body temperature, and oxygen levels all began to stabilize. A photographer in the hospital that day snapped a picture of the infants' embrace. The photo, now famously referred to as "the Rescuing Hug," appeared in both Life and Reader's Digestmagazines to great public acclaim. The twins' story highlighted the remarkable healing power of human touch and demonstrated to the medical profession the potential therapeutic benefits of physical contact. I think of that now as I enter one of the physical examination rooms in my clinic. Mike and his granddaughter sit patiently waiting there for


This paper describes the results of a study on new configurations for the windshield and the canopy of the M346, a new military trainer aircraft with two staggered seats, currently in phase of construction at Aermacchi (Venegono Superiore, Italy). The study carried out demonstrated that forward rotation allows a reduction of the weight of the structure, improves the visual field of the pilots and moreover, allows a greater accessibility to the panel instrumentation. Obviously, all the related aspects have been considered in the development of the study, such as the opening/closure, latching/unlatching and locking systems of the canopy, the tightness for pressurisation, tightness for water and dust also when the aircraft is parked, the resistance to bird impact, the forces due to wind when the canopy is opened on the ground and, in the case of emergency, the systems to break the transparent material and to eject the pilots.


passive attitude of the mystical, eastern traditions, and the 'reciprocity' of North American native religion but none of this is made very clear. Perhaps the most valuable of the essays is Santmire's 'Reflections on the Alleged Ecological Bankruptcy of Western Theology': those who found his earlier Brother Earth somewhat difficult and puzzling will find this essay refreshingly clear. Newbery's contribution, 'Ethics for Environment: Native American Insights,' is also of interest, although it seems somehow incomplete and fragmentary and lacks illustrations crucial to the text and documentation crucial to the argument. In addition to the five major addresses, the volume reprints selections from the ensuing discussions (probably a mistake


In this work, we report nonresonant surface-enhanced hyper-Raman (SEHRS) spectra of the amino acids tryptophan, histidine, phenylalanine, and tyrosine using silver nanoparticles. The spectra are obtained at an excitation wavelength of 1064 nm and compared to the corresponding surface-enhanced Raman scattering (SERS) spectra measured at 532 nm excitation. The majority of the bands in the SEHRS spectra are assigned. Important hallmarks of the spectra include strongly diminished or absent bands from the ring breathing modes. SEHRS and SERS spectra obtained from histidine and tyrosine indicate changes at slightly varied amino acid concentration. Small changes in the SEHRS spectra were more pronounced than variation in the corresponding SERS data, supporting the high sensitivity of the SEHRS spectra with respect to structural changes due to small variations in surface environment. The possibility to measure nonresonant SEHRS spectra of amino acids in solution and the complementary information obtained from the...


To solve the problem of low positioning precision of mobile robot in conventional manual test with low test efficiency,and pose measurement based on high-precision pose measurement tools show deficiency in a low degree of automation, which fails to be directly used to evaluate test results. This paper proposes a position precision based on high precision position measuring tool automation testing methods, which can not only solve the low conventional manual test precision, and when the positioning accuracy is required to reach a higher standard, the error caused by manual measurement makes the measurement result fails to be used as the evaluation benchmark.In addition, it can automatically collect pose points in the process of repeated autonomous movement of mobile robots, and then automatically analyze the pose error when reaching a specific position point every time. It is suitable for repeated testing in industrial scenes for a long time, and achieves the purpose of improving test efficiency and productivity.


Non–small cell lung carcinoma represents the most common form of lung cancer, which itself is the cancer responsible for most deaths annually worldwide. In the advances toward personalized medicine in cancer care, the liquid biopsy is the most recent leap forward allowing treatment based upon driver mutations harbored within a patient. Cell free DNA (cfDNA) is shed from cells within the body, and the tumor cells are no different. This circulating tumor DNA can be sampled and tested for therapeutic and diagnostically actionable genes and gene mutations. Because of the relatively uncommon nature of these circulating tumor DNA, the available tests are designed to have very high sensitivity, with the tradeoff of a more modest specificity. The data supporting the major commercially available liquid biopsies are reviewed and summarized. The most common use of the liquid biopsy is to test for actionable mutations, but other uses include monitoring for disease progression and testing for resistance mutations in patients undergoing treatment.


Abstract This paper describes the Ploeger Model of enhanced maternal and child health (EMCHN) nursing practice that has been operationalised since 1997.These EMCHNs work with families whose infants and children are exposed to violence. Family violence is complex and many layered. It presents a situation of fear and unpredictability that is difficult to identify and manage. If this situation continues during the child rearing years the effect on the health and wellbeing of infants and children may range from death to life long disabilities. Maternal, siblings and families' health and wellbeing can also be impacted upon for life.The need for enhanced skills for identifying and supporting vulnerable families and safeguarding children at risk has been highlighted by the Department of Health (2004). The Ploeger Model provides an example of early identification and intervention using both secondary and tertiary prevention strategies to identify and make referrals within a multidisciplinary, collaborative partnership, and a process of mutual clinical supervision. Another feature of the model is 'assertive outreach', which assists with early engagement with the family focusing on social support. Each of these helps achieve positive outcomes for children and their families. CSuch front line professionals must have the knowledge, skills, time and management support to work eff ectively with these families.