This paper pools the language of psychoanalysis with other disciplines to illuminate the very real and ephemeral experience of working with patients who experience states of nonbeing. Using the powerful imagery of Francesca Woodman's photographs, my patient and I enter the breach in her mind that trauma creates. Barthes, Benjamin, and art criticism enable me to relate to my patient's condition of trying to exist suspended between life and death.


Provided is a pulse drive-type field emission device. The pulse drive-type field emission device includes anode and cathode substrates that are spaced apart from and face each other, a cathode electrode formed on the cathode substrate, and a field emitter formed on the cathode electrode. The pulse drive-type field emission device further includes a metal mesh-type gate electrode having an opening through which electrons emitted from the field emitter pass and a power source which applies a compensated pulse wave power to the gate electrode or the cathode electrode to compensate for vibration of the gate electrode. Thus, noise from the metal mesh can be prevented without additional fabrication processes by modifying a waveform in pulse driving.


According to analysis of the current condition and the problems of electric construction project management, this paper discusses the necessity and feasibility of the "Agent-Construction System", presents out the project management mode that establish project management company hold by electric power group to agent construct the electric project, and adopt whole process management contain preparation, design, construction, adjustment and delivery.


The utility model relates to a hanging piece which is used for the manufacture of large sliding glass doors and windows, belonging to the hardware machine building. The purpose of the utility model is to provide the hanging piece of the sliding glass doors and windows; a driving method that rolling wheels are clamped and hung on both surfaces of the glass is used for the manufacture of the glass doors and windows. The utility model has the advantages of reasonable structure, easy processing and easy manufacture. The hanging piece clamps and hangs the glass with a stress, and can keep the strength of the class; the hanging piece can be arbitrarily connected with universal castors or double pulleys; the installation and the used are very convenient. The hanging piece comprises a front suspension hanging plate 1, a rear suspension hanging plate 2, decorative covers 41 and 42, etc. The hanging piece is characterized in that calabash-shaped salient plates 20 and 21 are arranged between the front suspension hanging plate 1 and the rear suspension hanging plate 2; a groove 22 and an arc-shaped groove 23 are arranged at the upper part of the calabash-shaped salient plate 20; the periphery of the arc-shaped groove 23 is provided with three long filament holes 24, 25 and 26. A dummy club 27, an arc-shaped groove hole 28 and an arc-shaped groove 29 are arranged at the upper part of the calabash-shaped salient plate 21; the periphery of the arc-shaped groove is provided with three sinker holes 30, 31 and 32; the rear plane of the rear suspension hanging plate is provided with a groove 33 and an arc-shaped groove 34; the salient plate 20 is connected with a guarding piece 35.


Axial Piston Pumps(APPs) have been widely used in industrial and mobile applications. To improve the operation performance, it is important to reduce pressure pulsations and noise level of APPs. The present paper, by analyzing the actual operating conditions in engineering point of view, proposes an iteration method of finding the reference operating conditions for designing valve plates in APPs with the overall best noise reduction performance within the entire pump operating range. The paper comes to conclusions that the noise level should be evaluated in a statistic way instead of at a working point. The best reference operating condition for valve plates design in APPs is not the rated condition, it can be found by an iteration method which will calculate a noise level index called the average pressure difference.


There is good agreement between the length of the lead–lead double bond calculated for H2Pb=PbH2 and that present in the tetraaryldiplumbene 1 (R=2,4,6-iPr3C6H2), which has now been synthesized and structurally characterized. Furthermore, the calculated and experimentally observed trans bent angles Θ are similar. Thus, compounds with homonuclear double bonds between all elements of Group 14 are now known.


Correction factors for evaluating maximum mesh-voltages associated with combined grid-multiple rods ground electrodes in two-layer soils are calculated for a wide set of ground electrodes to expand the application of available uniform soil expressions to nonuniform soil cases. Square and rectangular grids are examined reinforced by rods of fixed length distributed along the grid perimeter only and along the grid perimeter and grid diagonals. Results of the calculations of 2200 cases generated by varying electrodes and soil parameters are displayed as graphs appropriate for practical application. Approximate analytical expressions for correction factors are also derived matching reasonably well with the calculated data. These expressions offer an insight in the most effective ground electrodes parameters which might serve in the design process.


4: Lifting Vision, Building Responsibility, Living the Charism and Raising Performance 5: The Miniaturization of Human Identity: The Challenges to Learn and Lead Amidst Diversity 6: Conquering Challenges: Leading Christian Schools in Australia 7: Reforming Faith-Based Schools through Peace Education 8: Loneliness, Solitude and Dialogue for Leaders in Faith-Based Schools 9: Education toward Peace Leadership of Jewish and Muslim School Students in Israel 10: Faith-Based Schools and Religious Socialization Conclusion


All the known Permian material from the Great Basin and adjacent areas is considered. Representatives of Properrinites, Crimites, and Daraelites are described from the Wolfcampian of Nevada. From the Leonardian are recorded Perrinites, Popanoceras?, and Pseudogastrioceras in Arizona; Pseudogastrioceras in Utah; also Perrinites and Spirolegoceras, n. gen., in Idaho. An account of a new species of Stacheoceras from the Middle or Upper Permian of northern California is included. N THE region of the Great Basin, Late Paleozoic strata are extensively devel- oped anc well exposed. However, the only widespread ammonoid assemblage that they have yielded is Upper Mississippian in age, Pennsylvanian forms are entirely unknown, and Permian specimens are rare. During the present study an effort has been made to locate and investigate every reported occurrence of Permian ammonoids in the states west of the Rockies. Results


The Advanced Namespace Tools are a collection of Plan 9 software designed for the following goals: 1. Reliability, Resiliency, Recoverability make grids of Plan 9 machines tolerant to hardware and software failures. 2. Flexibility and Configurability make it easy to change what role a system is playing in a grid, to add in new systems, and retire old ones, without disrupting the user environment. 3. Multiplexing namespaces on one machine the standard Plan 9 installer sets up a Plan 9 environment with a namespace organized to appear similar to a traditional unix userland, and all software on the machine operates within this namespace. This is convention, not necessity, and the Plan 9 kernel can run multiple user environments with radically different namespaces on the same machine. One notable application of this is running both 9front userland and standard Bell Labs userland on the same box at the same time, one available viacpu and one via the terminal's physical display and i/o. 4. Ad-hoc namespaces built from multiple machines The converse of the previous goal is the ability to easily create an environment built from diverse and distinct services on different machines. This is part of standard Plan 9 concepts but the existing tools and scripts don't provide many commands for en masse namespace operations to apply numerous mounts and binds to a group of processes quickly. 5. Data sharing and persistence Multiple machines should be able to work easily with the same data, even dynamic, flowing data. Being able to study and replicate past data flows is useful. 6. Adminstration It should be easy for the user to administer all the machines used to create the workspace. Administration should be contained away from the main user environment, but constantly and easily accessible. 7. Automatic backup/replication and recovery. Redundant usable copies of data should be made automatically, and entering an earlier or alternate environment should be nondistruptive and fast.


The promary purpose of this study was to estimate relative abilities of each korean professional baketball team including opposing team or athletics thought appling hierachical nonlinear model. For performing this investigation, competition results for 2011-2012 season KBL were collected from KBL website. Bradley-Terry Model was used relative ability parameters in basketball teams and these was is estimated by linear model with explanatory variables such as competitive factors. Results follow as: 1. Relative abilities appeared to Dong-Bu>KGC>KT =MOVIS>Electronic land>Dong- Yang>SK>Samsung. 2. KGC, Dong-Bu, KCC, KT, MOVIS, Electronic land was shown significant difference in comparing the lowest team, Samsung. 3. In abilities predicted by explanatory variables, just 2point effected to relative abilities significantly.


The curvature of unsymmetrical [0/90] laminates moulded from AS4/8552 uni-directional tape has been measured. A linear thermoelastic approach has been applied to predict the related residual stress state before demoulding, giving an estimate of the stress induced by polymerisation strain. The results from the linear approach are confirmed by a viscoelastic finite element model including the cure conversion and related change in viscosity. It is concluded that the curvature measurement of unsymmetrical laminates is an accurate method for the prediction of the transverse residual stress, making it suitable as a benchmark for complex stress modelling.


The structural characteristics of aluminum alloy cover was analyzed,and the design of pouring system and die-casting die structure were introduced. In order to fill mold steadily,enhance a availability ratio of aluminum alloy and facilitate manufacturing the die easily,the design of branch runner system was adopted,and it can satisfy the design requirement of mold very well.After the trial in actual production,it is proved that the die is convenient to operate,safe and reliable,and the casting quality can meet the requirements.


The use of new methods for element-by-element diagnostics of the brake system increases the probability of detecting malfunctions, helps to identify faulty elements in the nodes of the brake system in advance, which helps to reduce accidents on the roads of the country. The development of a method for in-depth diagnosis of the master brake cylinder is an urgent task. Earlier, as part of the development of a new method for diagnosing the main brake cylinder of a hydraulic brake system, a set of diagnostic parameters was determined by the dynamic parameters of the resistance force to pressing the brake pedal. The need to introduce the method for practical use at road transport enterprises set the authors the task of determining the maximum permissible values of diagnostic parameters based on the comparison results, with which a conclusion will be made about the technical condition of the object with subsequent diagnosis. The aim of the work is to determine the maximum allowable values of diagnostic parameters, and to develop an algorithm for making a diagnosis. The maximum permissible values of the diagnostic parameters of the main brake cylinder were determined on the basis of a statistical method. The main provisions of the method are that a one-time sample of N values of the diagnostic parameter was considered for representatives of the set of diagnostic objects (both serviceable and faulty). At the same time, it was assumed that the values corresponding to the serviceable state would obey a different pattern than the values corresponding to the faulty one. Having singled out the distribution function f(S) of the parameter values for the healthy state of the object from the total population, the range of acceptable values of the diagnostic parameter in operation can be limited by some limiting dispersion relative to the nominal (reference) value of the parameter. For the braking system affecting traffic safety, the restriction was applied with 85% probability. The values were found for the entire range of diagnostic parameters. In the course of the study, the maximum permissible values of diagnostic parameters were determined. A diagnostic matrix of the main brake cylinder has been built. An algorithm for making a diagnosis has been developed. The scientific novelty lies in the difference in their implementation in the range of service braking, which makes it possible to maximize the informative possibility of each of the diagnostic parameters.


In the family described the father has a bilateral type I Duane syndrome. His son has a bilateral type III Duane syndrome. He showed no globe retraction and narrowing of palpebral fissures, but synkinetic jaw movements on intended lateral gaze.


Constructing small cities and towns in Gansu Province needs to seek the joint between the small-city construction and the rural economic development, to encourage labor-intensive rural enterprises, especially those agro-industries which supply the rural area and agriculture industry with inputs and consumption of local agriculture byproducts, and the rural area third industries which serve the agriculture industry with technology expansion, finance and insurance, etc. So that we can accelerate the non-agriculture process in rural area and increase the income of peasants, as a result, to prepare well for the transformation of traditional agriculture. Constructing small-city in Gansu province can be pushed forward in three aspects as follows: ladder-push stra- tegy, "characteristic industry prospering city" strategy and "point-axis" strategy.


Advances in microprocessors have focused interest on the development of simple aeroacoustic target‐location systems consisting of a small, few‐element sensor array followed by FFT analysis, which provide the acoustic bearing θ(t) and the apparent target frequency f(t) as functions of time. This paper discusses factors which may limit the practical applications of such systems: (i) Signal‐to‐noise effects lead to bearing fluctuations δθ(rms) ≈ [(1 − ρ)N/S]1/2/kd, where ρ = the noise correlation between the two detectors and d = their separation. (2) Subsonic target motion leads to a bearing bias of δθ ∼ M relative to line of sight. For a constant‐velocity trajectory, δθ = Arctan (f/fθ); an exact expression involving only measured quantities and their first derivatives. Expressions for other target/trajectory parameters involve higher derivatives as well. (3) Multipath/multitarget signals which overlap in frequency lead to bias errors when analyzed as a single target. For example, two such signals analyze...


This reseach was conducted on the project construction of abrasion beach located in the village of Biluhu middle district biluhu. Data collection was performed by questionnaires. The results of the survey questionnaire collected the 30 responpondents, then the data is analyzed with statistical analysis. Based on the test reliability coefficient obtained Cronbach Alpha of 0,637, thus it can be concluded that this variable realibe. The results of this study conducted with the test statistics and performed the ranking over the factors that cause the termination of the employment contract.based on the ranking, there are 8 (eight) factorsthat cause the occurrence of the termination of the emplyment contract that the employment relationship that is not harmonious with the owner, the method of implementation, shortage of labor, delays the star of the work, materials delivered are not in accordance, the working relationship that is not harmonious with the supervision consultant, the shortage of funds in the implementation of and mistake to interpret the image.


We propose an automatic segmentation method of renal parenchyma in abdominal MR images based on cascaded deep neural networks with image and shape patches. First, intensity and spacing normalization is performed in the whole MR image. Second, kidney is localized with the ensemble of 2D segmentation networks based on attention U-Net on the axial, coronal, sagittal plane. Third, signal intensity correction between each data is performed in the localized area, and renal parenchyma is segmented with the ensemble of two 3D segmentation networks based on UNet++ with image and shape patches. The average F1-score of renal parenchyma was 91.43% at left kidney, 89.30% at right kidney in F1-score, respectively.


A weighted least squares (WLS)estimator ispresented for timedifference ofarrival (TDOA) localization ofanemitter using multiple TDOAmeasurements collected bymoving receivers. A comprehensive biasanalysis forthis estimate is provided. Basedontheoutcomes ofthebiasanalysis, abias compensation algorithm isdeveloped toreduce thesevere WLS estimation bias. Theproposed algorithm utilizes anestimate oftheinstantaneous biasderived fromtheWLS estimate itself. Thesignificant bias reduction capability oftheproposed biascompensation algorithm isillustrated withsimulation examples involving geolocation ofapulse radar byunmanned aerial vehicles (UAVs).


The invention relates to a music data obtaining method, an earphone, a loudspeaker box, and a music player. The method comprises: an identification code is read from a memory card; the identification code is sent to a mobile terminal and thus the mobile terminal sends the identification code to a server, and the server feeds back music data stored by the corresponding identification code to the mobile terminal; a music signal that is converted from the music data obtained from the server by the mobile terminal is received; and the music signal is outputted. According to the invention, the user only needs to keep the memory card and can obtain the music data stored into the corresponding memory card identification code of the server when inserting the memory card into the earphone, loudspeaker box, or music player, thereby substantially improving convenience of music data obtaining by the user; and thus the user can enjoy music at any time at any place.


Background Neurological complications of vertebral osteomyelitis (VO) can be serious. In a previous work,1 we showed that they occur in up to 40% of the patients. Bed rest and spine immobilisation by bracing is prescribed to decrease pain but also to prevent those complications. There is currently no consensus about the best immobilisation protocol to follow in VO. French guidelines recommend bracing for all patients whereas recently published American recommendations did not even mention spine immobilisation. Objectives To describe the type and duration of prescription of spine immobilisation during VO. Methods A prospective multicenter study was performed in 7 French centres. All patients with VO were followed prospectively: neurological complications, imaging findings, type and duration of immobilisation were reported. We present here the data of our study after 3 months of follow-up. Results To date, 79 patients completed 3 months follow-up. Medium age was 67±15 years old with 66% of males. Median duration of symptoms before diagnosis was 27 days, IQR.11–40 37 patients (47%) had staphylococcal infection. 35% of the patients had an abnormal neurological exam at baseline: 18 patients (23%) had minor neurological signs (sensory loss, radiculopathy or pyramidal syndrom), and 10 (12%) had major neurological signs (motor deficit or cauda equine syndrom). During hospital stay, 5 patient developed major neurological signs (median 5 days after diagnosis) and 7 minor neurological signs (median 6 days after diagnosis). Half of the patients with abnormal neurological exam at baseline had functional sequelae at 3 months. On MRI, 17% of patients had epidural phlegmon, 20% had anterior effacement of subarachnoidal space, and 16% had involvement of cervical spine. All these MRI signs were significantly associated with major neurological complications (p=0.004, p=0.004 and p=0.002, respectively). Median duration of bed rest was 9 days (IQR 7–18). Overall, only 60% of patients have been immobilised by bracing (90% of rigid bracing). Median duration of prescription was 8 weeks, IQR.6–12 Patients who did not receive spine immobilisation had all a lumbar involvement, a normal neurological examination at baseline. None of them developed secondary neurological complications. They were no significant difference in age (72±16 versus 65±15 years old), sex or duration of the symptoms between patients who have been immobilised or not. Conclusions Neurological complications occurred in 35% of our patients as published in previous VO cohort. Interestingly, 40% of our patients were not treated with bracing. They all had lumbar involvement and normal initial neurological examination. None of them developed secondary neurological complications. Bed rest without bracing might be the best therapeutic option for these patients, preventing the morbidity associated with bracing. Reference [1] Bart, et al. Is There an Association Between Magnetic Resonance Imaging and Neurological Signs in Patients With Vertebral Osteomyelitis? A Retrospective Observational Study on 121 Patients. Medicine2016. Disclosure of Interest None declared


Choroidal melanoma is a primary malignant intraocular tumor with unfavorable vital prognosis. Factors predisposing to invasion of choroidal melanoma into the optic nerve include its juxtapapillary localization, the large tumor size, its diffuse growth, the presence of necrosis in the tumor, increased intraocular pressure and the epithelioid cell type of the tumor. The authors describe the clinical case of a 31-year-old patient with a primary diagnosis of an optic nerve neoplasm. Peripapillary edema and indistinct optic disc margins were found by ophthalmoscopy. There was a slightly protruding gray-slate lesion with indistinct boundaries near the optic nerve disc. The retina was edematous with multiple merging hemorrhages. The data obtained by echography (the focus protruding both inside the eye and along the optic nerve trunk), color Doppler mapping (single own vessels in the projection of the orbital part of the mass) and computed tomography allowed for the suspicion of the primary choroidal melanoma. To clarify the nature of the process, a trans-conjunctival orbitotomy with a revision of the orbit and the optic nerve was performed. The expansion of the proximal part of the optic nerve with partial breakthrough of the optic nerve shells was revealed intraoperatively. The patient underwent enucleation with morphological and molecular genetic verification of the primary choroidal melanoma with invasion of the optic nerve. The data obtained (absence of chromosome 3 monosomy, deletion of the short arm of chromosome 1, methylation of promoter regions of the RASSF1A gene, mutations in the 4 and 5 exons of the GNAQ gene, CT genotype of the polymorphic marker C3435T of the ABCB1 gene) indicate a relatively favorable vital prognosis, despite the extrascleral growth of the tumor and its mixed cell type. The patient underwent a course of anti-relapse proton irradiation of the orbit with a total dose of 58.8 Gy at 80–90% isodose. Currently, 7 years after the treatment, the patient continues to be followed up by ophthalmologists and oncologists, without any signs of local recurrence and distant metastases. This clinical example demonstrates the possibility of extraocular extension of a small intraocular choroidal melanoma simulating an optic nerve tumor, and confirms the need for a thorough clinical and instrumental examination for a correct diagnosis and adequate management of the patient.


Low‐pressure pulsed DC N2‐H2 plasmas with admixtures of CH4 were investigated in a comparative study in two different types of reactors, (i) a cylindrical industrial scale active screen plasma nitriding (ASPN) reactor and (ii) a laboratory scale plasma nitriding monitoring reactor (PLANIMOR) with a linear electrode configuration. Applying infrared laser absorption spectroscopy (IRLAS) the evolution of the molecular concentrations of four stable molecules, CH4, HCN, NH3, and C2H2 has been monitored. The degree of dissociation of the carbon containing precursor, CH4, varied between 80 and 95%. The concentrations of the molecular reaction products have been found in a range of 1011 to 1016 molecules cm–3. By analyzing the development of the molecular concentrations at changes of the screen plasma power, the gas mixture and the admixture of CH4, a similar behavior of the monitored species depending on the varied parameters has been found in both reactors with NH3 and HCN as the main products of plasma conversion. The fragmentation efficiency of methane has been determined, decreasing from 2.4 to 0.8 × 1015 molecules J–1 with the increasing power of the screen plasmas in both reactors. With the help of optical emission spectroscopy (OES) the rotational temperature of the N+2 ions in the plasma could be determined, being in a range of 650…920 K where the rotational temperature of the screen plasma in the ASPN reactor is approximately 100 K higher than that in PLANIMOR. Also with power the ionic component of nitrogen molecules, i.e. the intensity of the N+2 ‐(0‐0) band of the first negative system, which has been used as the reference parameter for comparing both reactors, increases strongly in relation to the intensity of the neutral component, represented by the N2‐(0‐0) band of the second positive system. In addition, steel samples have been treated in both the ASPN reactor and PLANIMOR leading to comparable nitriding results. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)


With the rapid development of national economy in China,the power consumption structure of East China Power Grid has changed correspondingly.Since DSM measures were widely and deeply applied to East China Power Grid in recent years,great changes have taken place to some sorts of social power consumption structures.The data of different sorts of power consumption structures are analyzed,and the characteristics of these sorts of power consumption structures are explained,providing reference for future DSM and load forecasting of the Grid.


Background:A high dose of opioids associated with a low dose of propofol has become a popular anesthetic technique. However, the influence of opioids on the electroencephalographic phenomenon related to induction of anesthesia and, thereby, on the quantitative parameters used in the depth-of-anesthesia estimation is not well known. Methods:Twenty-seven patients were divided into three groups to receive saline, low-dose remifentanil (7.5 μg · kg−1 · h−1) or high-dose remifentanil (30 μg · kg−1 · h−1) during induction of anesthesia with propofol (30 mg · kg−1 · h−1). Electroencephalogram was recorded from Fz electrode, and its time-frequency properties in the patient groups were analyzed from the induction of anesthesia to the occurrence of burst suppression pattern. The group differences in 14 quantitative spectral parameters used in the depth-of-anesthesia estimation were examined as well. Results:The time-frequency properties of electroencephalogram were different between groups. The high-frequency (greater than 14 Hz) activity during light anesthesia was decreased in remifentanil groups; whereas, increased activity in extended alpha band (7–14 Hz) and decreased activity in delta band (0.5–4 Hz) was observed during deep anesthesia. This resulted in statistically significant changes in all 14 quantitative parameters. Conclusions:The effect of remifentanil on the spectrum and quantitative parameters of electroencephalogram is significant and strongly dependent on the level of anesthesia. Coadministration of opioids therefore challenges the reliability of the spectral properties of electroencephalogram in the depth-of-anesthesia estimation by using a frontal montage. Furthermore, the finding has implications for design of opioid coadministration studies.


Criminal violence in Latin American cities is increasing. Meanwhile, with urbanization, greater numbers of people are moving to cities and into the crossfire. What self-protection strategies do residents adopt to keep safe in violent cities? Drawing on qualitative data from Medellín, Colombia, and Monterrey, Mexico, we document the strategies residents use to stay safe. We synthesize insights from studies of civil war, criminal governance, and urban violence to construct an analytical framework to systematically catalog and name these strategies. We posit that the type of violence residents face—indiscriminate or targeted—influences the strategies they pursue. Responding to either the indiscriminate or targeted form, residents employ survival strategies to avoid, withstand, or confront violence. Our research underscores the centrality of agency for residents' "staying power" amid urban violence.


This bachelor work deals with possible characteristics and options to create an internet commerce. The main content of the bachelor work is to analyse charakteristics of an internet commerce created with a developmental tool called Zoner INSHOP4 by Zoner Software, s. r. o. The next part of the work is comparative analysis with other tested products which are available on our market.


The distribution of computational tasks across a diverse set of geographically distributed heterogeneous resources is a critical issue in the realisation of true computational grids. Conventionally, workload allocation algorithms are divided into static and dynamic approaches. Whilst dynamic approaches frequently outperform static schemes, they usually require the collection and processing of detailed system information at frequent intervals - a task that can be both time consuming and unreliable in the real-world. This paper introduces a novel workload allocation algorithm for optimally distributing the workload produced by the arrival of batches of jobs. Results show that, for the arrival of batches of jobs, this workload allocation algorithm outperforms other commonly used algorithms in the static case. A hybrid scheduling approach (using this workload allocation algorithm), where information about the speed of computational resources is inferred from previously completed jobs, is then introduced and the efficiency of this approach demonstrated using a real world computational grid. These results are compared to the same workload allocation algorithm used in the static case and it can be seen that this hybrid approach comprehensively outperforms the static approach.


Persistent exposure of rats to 6‐propyl‐2‐thiouracil (PTU) from birth resulted in decreases in plasma thyroid hormone (TH) levels and hepatic expression of catalase and CCAAT enhancer binding protein β (C/EBP‐β). Catalase promoter region (–185 to +52) that contains binding sites for C/EBP‐β showed an augmentation in the methylation level along with a change in methylation pattern of CpG islands in response to PTU treatment. PTU withdrawal on 30 days of birth restored TH levels and C/EBP‐β to control rats in adulthood. Although catalase expression was restored to some extent in adult rats in response to PTU withdrawal, a permanent change in its promoter CpG methylation pattern was recorded. The results suggest that downregulation of adult hepatic catalase gene in response to persistent neonatal PTU exposure may not solely be attributed to thyroid‐disrupting properties of PTU. It is possible that besides thyroid‐disrupting behavior, PTU may impair expression of hepatic catalase by altering methylation pattern of its promoter.


In the two previous papers, we introduced a new method for measuring attenuation in reflection seismic data (Raji and Rietbrock, 2013), and a new algorithm for Q-compensation process to correct the undesirable effects of attenuation in seismograms (Raji and Rietbrock, 2012). We tested the methods with synthetic data examples, and where possible, compared our results with those achieved by other published methods. In this paper, we demonstrate the appropriateness of the Q measuring algorithm and the Q compensation scheme to field dataset, using a set of 3D data recorded in the Gullfaks field, Norway. The robust features of the Q measuring algorithm include the use of spectral shape factor and variable window length. The shape factor allows the user to represent the real seismic wavelet with several shapes without altering the mathematical formula, while variable window length reduced interference during spectral computation. The average interval 1/ calculated from 500 measurements at each of the four time-depth intervals are 0.0196, 0.0573, 0.0389, and 0.0220, for intervals AB, BC, CD, and DE, respectively. Variation in the attenuation structure of the survey area is described with 2D attenuation profiles. Attenuation compensation in field seismograms is also attempted. inverse filters are designed for the various earth layers approximated from the seismic traces, using the interval average 1/ . The inverse filtering scheme is applied to the traces one after the other using Matlab programs specifically designed for the study. The compensated data shows higher quality in terms of amplitude size, frequency content and image resolution, compared to the original field data. (


Earthworm cellosolve is prepared up through such technological steps as a particular strain of earthworm going through washing, mixing, breaking and extraction with distilled water, collecting extracted liquid by centrifugal method, the dialysis, ultrafilter, chemical dewatering and sterilization of extracted liquid to obtain concentrated liquid, and freeze drying to gain coarse cellosolve product whose activity is up to 8500 sq.mm/mg. It can be directly used in drugs.


: The selection of data warehousing solutions has become crucial for organizations looking for effective data management amid a time when businesses are rapidly transforming and data is growing exponentially. This paper thoroughly compares and contrasts the traditional on - premises data warehousing approach and the dynamic environment of cloud - based data warehousing. It carefully analyses each technique, shedding light on important factors like scalability, cost - effectiveness, adaptability, and data security. Moreover, this paper goes beyond the present - day landscape and examines the future scope of cloud - based data warehousing, taking into consideration emerging trends and technologies that are reshaping the data management environment. The scope of cloud - based data warehousing is also examined in this article, going beyond the current environment, and taking into account new trends and technological advancements that are changing the data management environment. Decision - makers will benefit greatly from this research's detailed grasp of the benefits and drawbacks of both paradigms as they attempt to successfully navigate the evolving data warehousing landscape.


Purpose: The present study explored the influence mechanism of the organic part of moral quality by validating if moral knowledge mediates the relation between moral awareness and moral behavior. Design: The present study used randomly stratified sampling method to sample 1,140 Chinese sports practitioners in southwest China and administrated the self-composed sports practitioner moral quality (SPMQ) questionnaire to the subjects for data collection. In addition, the present study applied regression analysis and structural equation modeling (SEM) techniques to explore the relationships among moral awareness, moral knowledge, and moral behavior. Findings: The present study showed two major findings. First, the SPMQ questionnaire showed good internal consistency since the overall Cronbach's α coefficient is 0.85 and the corresponding values of three sub-dimension were over 0.60. Also, it showed that the instrument had good construct validity because all factor loadings were higher than 0.70, all average extracted variances were higher than 0.60, and all composite reliability coefficients were higher than 0.80. Second, the results showed that moral knowledge played intermediate role between moral awareness and moral behavior in the relationships among moral awareness, moral knowledge, and moral behavior. Practical implications: The study is one of the very few research that discuss the mechanism of moral quality from the perspective of the mediation, especially explore the potential mediation effect of moral knowledge in conjunction with the relevant theories and practices.


This study reviews the performance of the temporary support systems used at four completed embedded retaining wall schemes. Soil berms were employed at three of these schemes and, at the other scheme, soil berms were used in conjunction with raked steel temporary props. The measured wall movements in each case are compared with those calculated by back-analysis using a finite element model. The effectiveness of the construction method is assessed from the numerical analyses by comparing predicted movements using soil berms (and raked props where appropriate) with those predicted if the alternative method of using horizontal propping near the top of the wall had been used. (A)


It is common practice to construct a pier-cap beam integrally with a box girder bridge. Any loading which causes flexure in the cap beam also causes twisting of the box girder. The torsion in the box girder tends to reduce the bending moments in the pier-cap and the piers. The objective herein is to present an analytic procedure which accounts rationally for this interaction and is easily applied in design.


Copper(II) carboxylates and their complexes especially with nitrogen donor ligands have already been widely studied but copper(II) carboxylates containing long alkyl chains are rarely reported. Long chain copper complexes are more soluble in less polar organic solvents and thus it may be expected that such systems will be more effective as selective, molecular homogenous catalysts. We hereby report the synthesis of a new copper(II) caprylate or octanoate of formula [Cu2(μ-O2CC7H15)4(4-CNpy)2] (4-CNpy = 4cyanopyridine) and characterize by single crystal X-ray diffraction. From crystal structure analyses, the compound is found to be dimer with the familiar paddle-wheel or lantern geometry. In the structure, each copper(II) atom has distorted square pyramidal geometry and are bridged by the carboxylate anions. Substituted pyridine ligands occupy the apical positions through the pyridyl nitrogen atom.


Abstract The paper shows that persons who have passed matriculation differ from the rest of the population in marital status and the number of live births. Marriage frequency among male students is higher, and that among female students lower, than that for the urban population of the same age. The proportion of childless marriages is smaller among male students than among the rest of the population. The trend of fertility has been different for students as compared with other males of the same age. Fertility among students (of 1910 and 1920) has risen and among the rest of the population of the same age it has fallen. The most striking difference between the students and the rest of the population is to be found in the fact that for the students there is a positive and for the rest of the (urban) population a negative correlation between income and number of children. Finally, the data suggest that among Swedish students there may be a slight positive correlation between intelligence and number of children.


Psoriasis, particularly when moderate to severe, is associated with an increased risk of incident chronic kidney disease (CKD)1, although specific renal diseases observed in psoriasis patients remain poorly defined. Of special interest is IgA nephropathy (IgAN), which presents with episodic macroscopic hematuria and can lead to CKD and end-stage kidney disease.

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P ERHAPS THE LEAST CONSPICUOUS ACTOR in the Southeast Asia crisis has been the Southeast Asia Treaty Organization (SEATO). Yet, the Southeast Asia Collective Defense Treaty, including its Protocol, extending over South Vietnam, Laos, and Cambodia, is relevant to actual events as they have unfolded since the treaty was signed in Manila in September I954. This article argues that SEATO is a failure, that it has failed to match action with the treaty concept and intentions (of providing for security in Southeast Asia through a regional alliance). The article explores the more important aspects of the external and internal dynamics of SEATO and seeks to support its assertion that the Treaty was conceptually, and in actuality, irrelevant to Southeast Asian situations. This article is oriented toward military and defense issues which were the raison d'tre for SEATO. It is recognized, however, that by separating itself from the overall fabric of political, social, cultural and religious issues in Southeast Asia, the article fails to present an overall picture and is as limited as was SEATO. It certainly does not attempt to provide general solutions to the region's current difficulties but is rather a critique of past performances, a critique which may, however, be of significance when the shooting stops in Vietnam and when practical and continuing political measures once more become necessary to provide security and stability in the region. It is not difficult to support the contention that strategically, SEATO had an inbuilt impotence. Construction of almost any simple but hypothetical strategic model for Southeast Asia illustrates this point.' In I954, wittingly or unwittingly, the United States, supported by its SEATO Allies, drew a Cold War frontier in Southeast Asia. This frontier stretched along the demarcation line in Vietnam and, generally, along the borders of Laos to Burma. Strategically three things may be done with a frontier-a power can advance from it, can retreat from it, or hold it. It was the basic role of SEATO to hold this Cold War frontier; it was defined in the Treaty by the words "to prevent, or to counter by appropriate means, any attempt ..... to subvert freedom or to destroy sovereignty or territorial integrity."


The intramolecular cyclization in hyperbranching polycondensation reactions of the type AB2/Bf was investigated both theoretically and experimentally. Hyperbranched aliphatic polyesters prepared from 2,2-bis(hydroxymethyl)propionic acid (BisMPA) and 1,1,1-tris(hydroxymethyl)propane (TMP) as B3 core molecule as well as commercially available samples with ethoxylated pentaerythrol as B4 core (Perstorp, Boltorn®) have been investigated with a combination of methods (NMR, vapor pressure osmometry (VPO), size exclusion chromatography (SEC), MALDI-TOF-MS) with respect to the formation of intramolecular cycles during polymerization. Absolute molecular weights were determined for the first time and found to be in the range of 632 (G2) to 1046 g/mol (G5) and 827 (PG2) to 1974 g/mol (PG5) for the commercial samples, respectively, i. e. considerably lower than reported previously. Theoretical considerations as well as experimental data clearly demonstrate cyclization to be an important reaction regardless of the presence of a core. The fraction if cyclized molecules was found to increase with molecular weights from 32% to 48%, limiting molecular weights drastically. In summary, previously reported results could not be confirmed. Incremental addition of the BisMPA monomer to the TMP-core did not permit to control molecular weights and the term "pseudogeneration" is inappropriate for the low molecular weight materials formed.


Purified sarcoplasmic reticulum vesicles from normal and dystrophic chicken skeletal muscle have been isolated by a procedure employing pressure disruption of a microsomal suspension. The dystrophic sarcoplasmic reticulum (SR) exhibited reduced Ca+ + transport and phosphoenzyme formation, but the Ca + + ‐ATPase activity was normal. Normal and dystrophic SR showed similar lipid profiles, except for a significant increase in free fatty acids in the dystrophic SR. Investigations involving the interaction of oleic acid with normal SR showed fatty acids can induce conditions similar to those found in dystrophic SR.


Introduction:Street family rehabilitation is a major problem in Nairobi County as the numbers keep rising despite rehabilitation efforts. The current study was to assess the factors affecting the effectiveness of street families' rehabilitation programs in Nairobi City County Kenya. Attachment theory was employed in the study. Methodology:The concurrent triangulation study design was employed. A sample of 135 respondents was selected through simple random sampling and data collected through questionnaires. Descriptive statistics was used to analyse data and presented in tables. Findings:The study revealed that poverty (28.2%) was the greatest demographic factor affecting the effectiveness of street family rehabilitation programs. Results also revealed that the main resource available for rehabilitating street families the County is personnel (36.4%) and funding (13.6%) were the main needed resource for rehabilitation and that resource availability (52.7%)negatively affected street family rehabilitation. Finally, financial mobilization at (37.3%) by rehabilitation personnel was the main technical expertise need for effective street family rehabilitation which further affects the effectiveness of street family rehabilitation programs in Nairobi City County. The study therefore concludes that demographic factors, resource availability as well as technical expertise negatively affect the effectiveness of street families' rehabilitation programs in Nairobi City County Kenya.


Consumers lacking extensive credit histories, having poor credit records, having inadequate income, or having high debt-to-income ratios may not qualify for loans under traditional underwriting standards. Consequently, alternative lenders have stepped in offering financing opportunities quickly and conveniently. The problem for consumers presents itself when the credit comes at a very high cost.The sub-prime financial services run the range from high dollar loans such as for housing to very small, short-terms loans such as what one may receive at a payday loan establishment.This chapter reviews five types of these financial transactions in what has become the fringe banking industry. These transactions are: pawn loans, auto title loans, rent-to-own loans, payday loans, and refund anticipation loans. All are expensive and allow the lenders to avoid consumer credit laws and disclosure statutes that can protect the debtor.


Objectives: The aim of this work was to assess the additive value of thyroid scan and uptake in the early diagnosis of interferon-α (IFN-α) induced thyroid dysfunction. Methods: Eighty HCVpositive Egyptian patients (30 males and 50 females, mean age 41.7±10.8 years) who received specific treatment in the form of IFN-α plus oral ribavirin. Patients with any thyroid disorder were excluded. Initial and 12 weeks after starting IFN-α treatment, all patients were subjected to 99mTc pertechnetate thyroid scan and uptake, free tetraiodothyronin (FT4), free triiodothyronin (FT3) and thyroid stimulating hormone (TSH), serum antithyroid autoantibodies including antithyroglobulin (TG-Ab), antiperoxidase (TPO-Ab) and anti-TSH (TSH-Ab). Neck US was done when indicated. Results: Seven patients (8.8%) developed hyperthyroidism (with elevated FT4, FT3 and suppressed TSH; mean 99mTc uptake = 10.5±5.15 vs 2.1±0.8% at base-line). Sixteen patients (20%) developed thyrotoxic phase of thyroiditis (with elevated FT4, FT3 and suppressed TSH; mean 99mTc uptake = 0.2±0.1 vs 1.0±0.6% at base-line). Significant elevation of TG-Ab and TSH-Ab was present in toxic patients compared with base-line. While, significant elevation of TG-Ab and TPO-Ab was present in thyroiditis patients compared with baseline. In toxic patients, 4/7 patients had clinical symptoms of thyrotoxicosis and US revealed hypervascularity in 3/7 patients while in thyroiditis patients, 8/16 Egyptian J. Nucl. Med., Vol. 14, No. 1, June 2017 63 patients had symptoms of transient thyrotoxicosis and US revealed features of destructive pattern in 5/16 patients. Conclusions: Thyroid dysfunction may occur as early as 3 months of starting IFNα therapy in a significant number of HCV patients. Thyroid uptake and scan could differentiate between Graves' disease and transient thyrotoxic phase of thyroiditis allowing for accurate management and can be added as a part of routine investigation together with thyroid hormonal profile and anti-thyroid autoantibodies especially if other investigations are not diagnostic.


A novel mechanical flux-adjusting permanent magnet linear eddy current brake with high performance and its nonlinear analytical model are proposed. The innovative point lies in attaching an additional mechanical magnetic adjuster directly above the interior permanent magnet bar, which can achieve flexible adjustment of the air-gap flux and improve the generation capacity of the braking force and its regulation range. Considering the importance of the analytic model in practical design, the average air-gap flux density and eddy current density are estimated based on the equivalent magnetic circuit method and Ampere's law, where the critical flux-weakening effect and leakage flux effect are calculated quantitatively. Then a practical theoretical model of braking force is derived based on the energy conversion and verified by the 3D finite-element method. Through analysis of the magnitude and regulation range of the braking force in a given range of speed, the advantages of the device and the electromagnetic force model are proved separately. Moreover, design suggestions for selecting the key geometrical parameters are further given, which offer useful information for pre-design and optimization.


Adsorption is most commonly applied process for the removal of pollutants such as dyes and heavy metals ions from wastewater. The present work talks about preparing graphenic material attached sand grains called graphene sand composite (GSC) by using ordinary sugar as a carbon source. Physical morphology and chemical composition of GSC was examined by using (FTIR, SEM, EDAX and XRD). Efficiency of GSC in the adsorption of organic dyes from water was investigated using reactive green dye with different parameters such as (ph, temperature, contact time and dose). Adsorption isotherm was also studied and the results showed that the maximum adsorption capacity of dye is 28.98 mg/g. This fast, low-cost process can be used to manufacture commercial filters to treat contaminated water using appropriate engineering designs.


The present invention is to provide a method of manufacturing a microneedle array using an X- ray process, the present invention includes the steps of making the X- ray mask to form the absorption body of the microneedle array structure on a silicon substrate; Step to produce the microneedle array PMMA mold by vertically inclined light exposure and exposure X- ray over PMMA by using the X- ray mask; Step of making a flexible PDMS mold having a shape opposite to pour the PDMS mold onto the PMMA; To form a desired thickness of the polymer filled with the gel form over the PDMS mold; Etching a hole in the form of a desired shape by irradiating UV to the polymer; It characterized in that it comprises a; the PDMS mold were removed to complete the steps of the microneedle arrays of the polymer material. Such microneedle array according to the present invention is an apparatus for extracting blood from the skin using a polymer material, or the drug injection.


Objective To explore the effect of MPT64 antigen from Mycobacterium tuberculosis on RAW264.7 macrophages and the related mechanism.Methods MPT64 was purified after expression in E.coli and verified by Western blotting analysis.The RAW264.7 differentiation was induced by phorbol myristate acetate(PMA) and the resultant cells were divided into three groups according to different treatments:negative control,purified protein derivative of BCG(BCG-PPD) and BCG-PPD+MPT64 treatment groups.After 16 h incubation,flow cytometry was used to examine apoptosis of macrophages, and the levels of TNF-αand IL-10 in the supernatants were determined by ELISA.Results BCG-PPD treatment induced apoptosis of RAW264.7 macrophages,and compared with BCG-PPD group,the apoptotic level of macrophages was significantly lower in BCG-PPD+MPT64 group(P0.05).We also found that the supernatant TNFαlevel in the BCG-PPD group was significantly higher than that in negative group(P0.01) and the IL-10 levels were not significantly defferent between the two groups.Compared with BCG-PPD group,the IL-10 level was significantly increased in BCG-PPD+MPT64 group(P0.01) and the TNF-αlevels were not significantly different between the two groups.Conclusion MPT64 may act as a virulence factor and can inhibit the apoptosis of macrophages induced by BCG-PPD,which is probably through increasing IL-10 level.


One of the most surprising results obtained with the Spitzer space telescope was the discovery of powerful mid‐IR H2 line emission from a significant number of sources that are in active phases of galaxy evolution, in which star formation seems strongly suppressed. The underlying physics may be a key ingredient to describe the buildup of baryonic mass in galaxies and their evolution. We present here two multiwavelength studies of an interacting galaxy system, Stephan's Quintet, and an AGN host radio galaxy, 3C326, which suggest that the H2 line emission heralds the dissipation of kinetic energy in a multiphase medium. The results provide new insight on the energetics of galaxy formation.


The conception of Non-Keplerian orbit was described and its applications were discussed.Firstly,as a direction the Keplerian Law was given which in fact as a very creative summarization of the observation results of planets,and it can describe the kinematical principle of planet motion.Then,the concept of Non-Keplerian orbit is given,which is the inevitable result of artificial satellite controllability.In succession,the typical problems of non-Keplerian orbit are described,including kinematical problem of spacecraft in single center gravitation field(viz.two-body problem) and in muilt-center gravitation field(viz.multi-body problem).The spiral climbing orbit and suspension orbit are studied as specific case.Finally,the applications of non-Keplerian orbit were put forward,including problem of kinetic energy interception,satellite formation and reconfiguration,optimal maneuvering of system integrated configuration.


This paper was presented at the Symposium on Aspects of the Chemistry Pharmacology and Clinical Use of a New Progestagen-Norgestrel (Wy-3707) at the Royal College of Physicians February 1968. Beginning in 1964 under the auspices of the Council for the Investigation of Fertility Control norgestrel (18 methyl norethisterone) a new totally synthetic potent steroid was tested 1) in preliminary studies of 6 different combined oral contraceptive preparations in which the dose of DL norgestrel varied from .1 to 3.0 mg and that of ethinyl estradiol remained constant at .05 mg and 2) in detailed trials of similar combinations containing 1.0 mg and .5 mg of DL norgestrel (Ovran). Preliminary studies indicate that the 3.0-mg and 2.0-mg tablets contained an unnecessarily high dose of norgestrel and that cycle control was unsatisfactory with .25- and .1-mg tablets. 139 women completed 1993 cycles on the 1.0-mg tablet and 173 women 2315 cycles on Ovran. Cycle control was excellent. Incidence of side effects was similar with both drug levels and with other oral contraceptives but headache occurred more often with the 1.0-mg than with the .5-mg tablet. Endometrial biopsies showed strongly progestagenic effect of both combinations but with .5 mg of norgestrel there was more evidence of an estrogenic effect. In the vagina a cytologically normal smear was produced by the 1.0-mg tablet and a fairly marked estrogenic one by .5 mg. Reasons for cessation of therapy are given. A greater proportion of withdrawals took place during the first 12 cycles irrespective of reason. 10 of 13 women discontinuing therapy for desired pregnancy conceived within 12 months of stopping oral contraceptive use. Both 1.0-mg and .5-mg DL norgestrel combined with .05 mg of ethinyl oestradiol have been approved for use in clinics of the British Family Planning Association.


Accurate fuel supply is a key factor that influences the performance of high-power natural gas engines. The premixed and single-point natural gas supply system is the most commonly used method to ensure a large fuel supply but one of its shortcomings is the inaccuracy of the fuel supply. A new type of natural gas injection device with fungiform configuration and electronically controlled actuator was developed to achieve high efficiency and stable operation in high-power natural gas engines. Firstly, a computational fluid dynamics (CFD) model of the injection device was created. Based on this model, the key structure parameters that have a significant influence on the outlet flow were confirmed. A particle swarm optimization (PSO) model was developed to identify the optimal outflow structure. Then, a flow function for precise flow supply control was constructed based on a response surface model, according to the flow rates of the device under different control parameters. Finally, a flow-characteristic test bench and a high-power engine prototype were developed to verify the simulation and optimization results. The results indicate that the optimized outflow structure shows low pressure loss and a large flow rate, improving injection efficiency by 10.37% and mass flow by 11.78% under 0.4 Mpa pressure difference. More importantly, the cycle fuel supply could be controlled accurately for each cylinder owing to the developed flow function. Consequently, compared with the original engine using a single-point natural gas supply system, the cylinder performance imbalance was improved by 37.47%.


The present study describes a gastroretentive floating controlled drug delivery system containing torsemide in the form of microsphere prepared by ionic gelation technique and evaluated for its processing parameters. Nine formulations containing retardant material such as sodium alginate and HPMC K15, foam forming agent sodium bicarbonate were prepared loaded with torsemide. Solid, discrete and reproducible free flowing microspheres were obtained. The microspheres had almost smooth surface with free flowing and good packing properties. The micromeretic study indicated that the obtained angle of repose, % compressibility index values were lie with in the limit.The prepared microspheres were characterized for their entrapment efficiency, particle size, floating ability, in-vitro release behavior, scanning electron microscopy (SEM) and differential scanning calorimeter (DSC).The in-vitro dissolution studies were carried out in the USP dissolution Apparatus-2 in 0.1N HCl at 50 rpm at 37±0.5 °C. Microspheres remain buoyant over a period of 8hrs in the release medium and the amount of sodium bicarbonate was found to be significant for remaining buoyant. It was found that the torsemide floating microspheres can be successfully prepared having high entrapment efficiency and prolonged released behavior with a substantial floating ability.


This study was done with the aim to identify the specific ergonomic risk factors in the workplace affecting the both male and female workers while doing raw brick making activities and to analyze the pain/discomfort related to it. Twenty male and twenty female workers from the raw brick making unit were randomly selected and a detailed ergonomic risk factors were analyzed with the help of NIOSH Ergonomic Hazard Identification checklist. The questions were based on the primary job responsibility of the workers. Data revealed that nearly 8 percent males and 10 percent females were in 'usually' category, 25 percent males and 28 percent females in 'sometimes' and approximately 18 percent male and 13 percent females who never performed the task were kept in the category 'never'. It was found that all the male and female workers usually require exerting force with their hands and used the hand tools to do the task. About 8 percent males and 5 percent females were usually, 15 percent male and only 10 percent female were sometimes and 28 percent males and 35 percent female were never stood continuously for a period of more than 30 minutes. On the whole all the male and female respondents were lifting or lowering the objects between floor and waist height or shoulder height and most of the workers were becoming exposed to the vibration while performing the task and they were carrying the weight more than 50 lb. The study indicates that the majority of the activities are in the high risk category and demands immediate ergonomic intervention in the form of tool, workstation and process design.


Substantial evidence has indicated that cAMP-dependent protein kinase (protein kinase A orPKA) plays a critical role in maintaining meiotic prophase arrest in vertebrate oocytes.However, PKA activity dynamic and its physiological substrate profile remain poorly defined.We have recently developed a novel PKA substrate construct which we employ to monitor PKAactivity in live oocytes. In the current study, we have employed biochemical and imaginganalyses of single cells to determine PKA activity dynamics during oocyte maturation and toinvestigate the consequence of re-activation of PKA during oocyte maturation. Wedemonstrated here that progesterone caused a rapid and permanent inhibition of PKA during theentire maturation process. However, artificial reactivation of endogenous PKA had differentialconsequences, depending on the timing of PKA reactivation. Reactivation of endogenous PKAat any time prior to GVBD inhibited progesterone-induced GVBD. PKA reactivation at GVBD,or thereafter, did not interfere with meiosis I to meiosis II transition, nor did it interfere withmetaphase II arrest. These results demonstrate for the first time a PKA-restricted phase and aPKA-permissive phase during oocyte maturation.


The co-existence of different traffic with quality of service (QoS) requirements limits the scalability of queuing and scheduling strategies. Two basic single stage queuing strategies implemented in routers are Output Queuing (OQ) and Input Queuing (IQ). OQ offers optimal throughput and guarantees QoS but it is not scalable. Even though IQ is simple and has been identified as the most scalable, the optimum throughput achievable is 58.6% due to Head of Line (HoL) blocking. Virtual Output Queuing (VOQ), a proffered solution to HoL blocking can achieve 100% throughput with an effective scheduling algorithm. Most of the existing schedulers for VOQ are deterministic algorithms which either guarantee QoS or do not. However, the deterministic algorithms that guarantee QoS have high time complexity. This paper proposes a probabilistic scheduling algorithm known as Iterative Probabilistic Scheduling (IPS) for the VOQ. The queuing architecture presented is a multi-stage queuing and scheduling (MQAS) in which VOQ is implemented at the input port and OQ at the output port of the router.


I THANK you for the honour you have conferred on me, at the end of nearly a quarter of a century, in electing me once again as your President. It is one I greatly appreciate, and more especially as it affords me an opportunity of showing how the surgical instinct I took as my text before is as essential as ever to make a good surgeon. It has become the fashion in recent years to belittle the work of those pioneers who laid the foundations on which modern surgical reputations have been built. The main object of my address now will be to indicate as briefly as I can the materials on which those foundations were laid; and it occurred to me I could not take a better text than the life-work of one of the most famous surgeons in this country a century ago-that of Astley Paston Cooper. I can in my own experience look back for more than half that period; and, while I recognize with admiration the enormous advances which have been made, I feel that we ought not to lose sight of the magnificent work of those to whom we are so deeply indebted. When I was


Creating innovative, participatory and collaborative, interactive spaces that invite, engage and include urban youth is a challenge, particularly in the setting of research and participatory culture projects. Youth is involved in their ways and activities of own making. It is often challenging for researchers to get them involved in cultural or civic activities that are part of research projects. On the other hand, access to youth cultures and subcultures can be difficult for researchers. Thus, in this workshop, we would like to discuss research approaches and methods of engaging youth in civic and participatory culture projects. Aiming towards a methodology to guide research in this area, the workshop explores diverse methods that are presently used in conjunction with participatory models and forms of cultural and civic engagement and new technologies of participation. Of particular interest are temporality (duration of engagement), outcomes (short and long-term, for researchers and youth) and the roles of digital means to scaffold participation, co-creation, or artifacts resulting from such participatory activities.


In this paper, we investigate the prime spectrum of an integral domain R with a finite number of spectral semistar operations. This will be done by seeking for a possible link between the cardinality of the set SpSS(R) of all spectral semistar operations on R and its Krull dimension. In particular, we prove that if |SpSS(R)|=n+dimR, then 2|Max(R)|≤ n+1. This leads us to give a complete description for the spectrum of a domain R such that |SpSS(R)|=n+dimR for 1 ≤ n ≤ 5.


The structure of polymeric microemulsions, viz. toluene/water/PS-PEO graft copolymer/2-propanol, has been studied by 1H-NMR spectroscopy. Results show that at low water contents, the copolymer adopts a rather diffuse micellar structure in which the rotational mobility of the ethylene oxide units is little affected by the ternary solvent mixture. Above a critical water concentration (ca. 4%), a restriction in mobility of the ethylene oxide chains is observed which has been related to the formation of an inverse micellar structure with water solubilized within the particles. The study of the chemical shifts and linewidths of water protons indicates that initially most of the water is hydrogen bonded to the hydrophilic part of the copolymer, then is present in its free form in water aggregates. These results confirm previous data obtained by dialysis equilibrium experiments.


The environmental risk associated with genetically modified organisms (GMO) implies that new approaches to risk assessment, risk management and risk communication are needed. In this paper we discuss the role of the precautionary principle in policy responses to GMO risk. We first discuss application of the criteria in the European Environment Agency report "Late lessons from early warnings: The precautionary principle 1896–2000" to environmental GMO risk, with focus on crop plants. Moreover, we discuss Bayesian analysis in the context of improving the informational basis for decision‐making under uncertainty. Finally, environmental uncertainties are intertwined with economic uncertainties. Providing incentives for improved risk assessment, risk management and risk communication is crucial for enhancing environmental and social responsibility and thereby facilitate implementation of precautionary approaches. We discuss environmental and social screening of companies as an example of how such incentives can be provided.


Recently the Modified Fermat Number Transform (MFNT) was extended to a Quadratic MFNT (QMFNT) by combining Right Circular Convolution (RCC) and Left Circular Convolution (LCC) to produce a quadratic representation of the convolution output. This paper investigates nesting of two distinct quadratic number representations, the first associated with quadratic coding of complex input sequences, and the second associated with QMFNT block processing. Quadratic coding of complex sequences combined with QMFNT block processing eliminates cross-products in the complex multiplication. Finally, a generalized form of the QMFNT (GMFNT) is introduced and then extended into two dimensions.


The Fast Fourier Transform (FFT) is still a widely-used tool for analyzing and measuring both stationary and transient signals in power system harmonics. However, the misapplications of FFT can lead to incorrect results caused by some problems such as aliasing effect, spectral leakage and picket-fence effect. A strategy of iterative Group-harmonic Energy Distribution Minimizing (GEDM) algorithm is developed for system-wide harmonic/inter-harmonic evaluation in power systems. The proposed algorithm can restore the dispersing spectral leakage energy caused by the FFT, and regain its harmonic/inter-harmonic magnitude and respective frequency. Every iteration loop for harmonic/interharmonic evaluation can guarantee to be convergent. Consequently, not only high-precision in integer harmonic measurement can be retained, but also the inter-harmonics can be identified accurately, particularly under system frequency drift. The numerical example is presented to verify the proposed algorithm in term of robust, fast and precise performance.


In order to improve the accuracy of fast reactor physical analysis, two libraries with 1968-group neutron and 21-group photon were generated based on ENDF/B-VIII.0 and ENDF/B-VII.1 data by using NJOY2016. A code, named TXMAT2.0, was developed to process the two libraries to generate ultrafine group neutron and photon cross sections and Kinetic Energy Release in Material (KERMA) factors. To perform the verification of the two libraries, ICSBEP benchmarks for critical verification, and the sample 1D benchmark were selected. Several results were in good agreement with reference data. For the RBEC-M benchmark, the power distribution based on the ultrafine group library was good.


: Background and Aim: The most common form of primary liver cancer in adults is hepatocellular carcinoma (HCC), and it is the most common cause of death in people with cirrhosis. The mammalian Sir2 family or sirtuins is formed of a cluster of highly conserved proteins triggering nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase activity which target histone and non-histone substrates including enzymes, transcription regulators, tumor suppressors, cell signaling proteins and DNA repair proteins. Seven human sirtuins have been identified and named SIRT1-7. SIRT1 has been regarded as a tumor promoter due to its increased expression in some types of cancers and its role in the inactivation of proteins involved in tumor suppression and DNA damage repair. We aimed to estimate the level of SIRT-1 in the blood of HBV, HCV, and HCC patients, to investigate the possible role of SIRT-1 in the pathogenesis of HCC and to determine the role of SIRT-1 as a tumor marker or pomoter compared to other markers like α-feto protein. Subjects and Methods: This study was performed in Internal Medicine department Beni-Suef Hospital. Our study included 160 individuals; divided into four groups; group A (healthy control), group B (HBV patients), group C (HCV patients) and group D (HCC patients). The serum level of SIRT-1 was assessed and compared in all groups and correlate its level as a tumor marker with the other marker α-fetoprotein. Results: There was significant increase in SIRT-1 levels in HBV, HCV and HCC group as compared to chronic noncancerous viral liver parenchyma diseases, so it may be included in pathogenesis of HCC. SIRT-1 may have matchable specificity and sensitivity as AFP in HCC patients.


Capacity Scaling Laws of Information Dissemination Modalities in Wireless Ad Hoc Networks Zheng Wang † , Hamid R. Sadjadpour † , J.J. Garcia-Luna-Aceves ‡ Department of Electrical Engineering † and Computer Engineering ‡ University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA Palo Alto Research Center (PARC), 3333 Coyote Hill Road, Palo Alto, CA 94304, USA Email: { wzgold, hamid, jj } @soe.ucsc.edu Abstract—We present capacity scaling laws for random wire- less ad hoc networks under (n, m, k)-cast formulation, where n, m, and k denote the number of nodes in the network, the number of destinations for each communication group, and the actual number of communication group members that receive information (i. e., k ≤ m ≤ n), respectively and when nodes are endowed with multi-packet transmission (MPT) or multi-packet reception (MPR) i capabilities. We show that Θ (T (n) m/k), Θ (1/k), and Θ T 2 (n) bits per second constitute a tight bound for the throughput capacity of random wireless i ad hoc networks under the protocol model when m = ¢ O T −2 (n) , Ω(k) = T (n) = O(m), and k = Ω T (n) , respectively. This result applies to both MPR and MPT, where T (n) denotes the transceiver range, which depends on the complexity of ´ the ³p log n/n to nodes. For the minimum transceiver range of Θ guarantee network connectivity, a gain of Θ(log n) for (n, m, k)-casting is attained with either MPT or MPR compared to the capacity attained when transmitters and receivers can encode and decode at most one transmission at a time (i.e., point-to- point communication). I. I NTRODUCTION Gupta and Kumar [1] studied the capacity of wireless ad hoc networks for the case of multi-pair unicasts in which the nodes are able to encode and decode at most one packet at a time. This work has motivated a large body of work over the past few years, which we summarize in Section II. One important area of the resulting research has focused on the study of different approaches to "embrace interference" in order to increase the capacity of wireless ad hoc networks. Embracing interference consists of increasing the concurrency with which the channel is accessed. We denote by multi- packet reception (MPR) [2] the ability of a receiver node to decode correctly multiple packets transmitted concurrently from different nodes, and by multi-packet transmission (MPT) the ability of a transmitter node to transmit concurrently multiple packets to different nodes. In practice, MPR and MPT can be achieved with a variety of techniques. For example, MPR can be implemented by allowing a node to decode multiple concurrent packets using multiuser detection (MUD); MPR or MPT capabilities can be implemented utilizing direc- tional antennas [3] or multiple input multiple output (MIMO) techniques. A complementary approach to embracing interference con- sists of increasing the amount of information sent per trans- mission. Network coding (NC) [4] was introduced and shown to achieve the optimal capacity for single-source multicast in directed graphs corresponding to wired networks in which nodes are connected by point-to-point links. Since then, many attempts have been made to apply NC to wireless ad hoc networks, and recent work [5]–[8] has shown promising results on the application of NC in wireless ad hoc networks subject to multicast traffic. Interestingly, a careful review of these con- tributions reveals that analog network coding [5] and physical- layer network coding [6] implicitly require the integration of NC with a form of MPR, in that receivers must be allowed to decode successfully concurrent transmissions from multiple senders by taking advantage of the modulation scheme used at the physical layer (e.g., MSK modulation in ANC [5]). Similarly, [7]–[9] the other recent NC schemes discussed for wireless networks assume the integration of NC with MPR and MPT. The work reported in this paper is motivated by two aspects of the prior work to date. First, while it is clear from recent work on NC that it is necessary to decouple the performance gains due to NC (i.e., combining multiple packets into a single transmission) from those resulting from MPR or MPT (i.e., allowing multiple transmissions to be received or sent at the same time). Second, no results have been reported on the order capacity of networks with MPR subject to broadcast, multicast or anycast traffic. Section III presents the first contribution of this paper, which is a modeling framework for the computation of the throughput capacity of random wireless ad hoc networks with MPT or MPR subject to any type of information dissemination modality. Sections IV and V present the upper and lower bound results on the capacity of ad hoc networks with MPR or MPT under different forms of information dissemination. In particular, we show that the per source-destination (n, m, k)- cast throughput capacity C m,k (n) of a wireless random ad hoc network with MPT or √ MPR is tight bounded (upper and ¢ lower bounds) by Θ (T (n) m/k), Θ (1/k) and Θ T 2 (n) w.h.p. 1 1 An event occurs with high probability (w.h.p.) if its probability tends to one as n goes to infinity. Θ, Ω and O are the standard order bounds.


Abstract : The possibility exists that a labor union within the military services of the United States could become a reality with the advent of an all- volunteer armed force. The actual probability of such an event being indeterminant at this time, the situation should be closely studied to determine the advantages and disadvantages of military unionization are presented along with the possible limitations on a military union should it become a reality. Two military unions operating with some degree of success in West Germany and Norway, respectively, are analyzed. Limitations common to both the Norwegian and West German unions are discussed to determine their possible applicability to the armed forces of the United States.


After a certain time, a calibration of ADS40 is essential, including determination of the coordinate assigned to each pixel in focal plate and IMU misalignment, so-named calibration file. There are two ways of calibration: laboratory calibration and test field calibration. The test field calibration leads to greater precision than the other one, because it is performed under realistic working conditions. In recent years, many papers focused on estimating the performance of the calibration file and the influence of self-calibration. Nevertheless, the goal of this paper was to generate a sufficient calibration file based on test field calibration. In this paper, mathematic models involved with calibration were introduced, and a calibration workflow was developed, consisting of estimation, calibration and verification. All the experiment data was provided by Wuhan University, including calibration blocks acquired over Songshan Testsite in August 2009, while the certification of calibration file of ADS40 was provided in February 01,2007, and the coordinates of all the ground control points (GCPs) with an accuracy of 1cm. Based on the original calibration file, aerial triangulation was performed. Self-calibration improved accuracy of data processing obviously, which indicated the necessity of calibration. Then a new calibration file was generated, which was different from the original one. With two sets of data in different flight height, a comparison of performance between the original calibration file and the new one was made, which proved the latter one to be sufficient and reliable.


Objective: To establish a better method based on chromatography (HPLE and TLC) to detect oxysophocarpin: a related residual compound in kurarinone capsules.Methods: The related compound in kurarinone capsules was determined by HPLC and TLC. HPLC condition: using a column packed with ZORBAX NH 2 and acetonitrile-alcohol-phosphoric acid solution(pH=2.0)80:8:12 as mobile phase, 220nm as datection wavelength; flow rate: 1.2ml/min.TLC condition: silicongel G plate as the stationary phase, the chloroform-methanol-strong ammonia solution(50:6:3) as the mobile phase. Results: The detection limit was 1.0ng in HPLC. The lowest detectable amount was 0.4μg by TLC. Conclusion: The HPLC method is sensitive, accurate and can be used for the determination of related residual compound oxysophocarpine in kurarinone capsules.


The Radiation and Nuclear Countermeasures Program within the National Institute of Allergy and Infectious Diseases (NIAID), is tasked with the mandate of identifying biodosimetry tests to assess exposure and medical countermeasures (MCMs) to mitigate/treat injuries to individuals exposed to significant doses of ionizing radiation from a radiological/nuclear incident, hosted. To fulfill this mandate, the Radiation and Nuclear Countermeasures Program (RNCP), hosted a workshop in 2018 workshop entitled "Policies and Regulatory Pathways to U.S. FDA licensure: Radiation Countermeasures and Biodosimetry Devices." The purpose of the meeting was to facilitate the advancement of MCMs and biodosimetry devices by assessing the research devices and animal models used in preclinical studies; government policies on reproducibility, rigor and robustness; regulatory considerations for MCMs and biodosimetry devices; and lessons learned from sponsors of early stage MCM or biodosimetry devices. Meeting presentations were followed by a NIAID-led, open discussion among academic investigators, industry researchers and U.S. government representatives.


A display device is disclosed. A display device according to an embodiment of the present specification includes a display unit configured to display visual information, a camera unit configured to capture an image in front of the display device, a sensor unit configured to sense user input applied to the display device, and a control unit configured to control the display device, wherein the control unit detects at least one user from the captured image, maintains display of the visual information and processes received user input when the detected user includes a predetermined master user, the control unit detects at least one user from the captured image, maintains display of the visual information and does not process the received user input when the detected user does not include the predetermined master user, and the control unit deactivates the display unit when no user is detected in the captured image.


We study the ground-state properties and nonequilibrium dynamics of hard-core bosons confined in one-dimensional lattices in the presence of an additional periodic potential (superlattice) and a harmonic trap. The dynamics is analyzed after a sudden switch-on or switch-off of the superlattice potential, which can bring the system into insulating or superfluid phases, respectively. A collapse and revival of the zero-momentum peak can be seen in the first case. We study in detail the relaxation of these integrable systems towards equilibrium. We show how after relaxation time averages of physical observables, like the momentum distribution function, can be predicted by means of a generalization of the Gibbs distribution.


He didn't send the book he wanted with the last letter as he was hoping to find the other book he wanted and then he could then send them altogether. Letters between Andrew Inglis Clark, Tasmania and Joseph G. Witton, Melbourne, 13 Sept 1882 - 9 Dec 1885 regarding his work as a law clerk in Melbourne, his friends, especially Walter Gill, religion, the Unitarian Church, George Walters, Mrs Webster, visit of Moncure Conway in 1883, family, health, Miss Witton's estate in England, books, chess and the foundation of the Chess Club 1883-4, visit to Ballarat, U.S. Independence Day 1883.
C4/C334


The idea of cultivating students' competence of thinking in English has been widely accepted among middle schools and elementary schools as a measure of English teaching reform.This idea is based on a false inference drawn from the notions of cultivating students' minds in the New English Curriculums and the related documents.Thinking is prior to language,and it selects automatically a language for expression.Thus to cultivate students' competence of thinking in English is infeasible.The difficulties of English Learning aroused by different ways of thinking between English speakers and Chinese speakers may be overcome by raising culture awareness among students.The reflections on cultivating students' competence of thinking in English are vital to English teaching reform,as this notion has already been part of teachers' conception on English teaching reform.


We present mid-IR interferometric observations of 6 type 1 AGNs at multiple baseline lengths of 27--130m, reaching high angular resolutions up to lambda/B~0.02 arcseconds. For two of the targets, we have simultaneous near-IR interferometric measurements as well. The multiple baseline data directly probe the radial distribution of the material on sub-pc scales. Within our sample, which is small but spans over ~2.5 orders of magnitudes in the UV/optical luminosity L of the central engine, the radial distribution clearly and systematically changes with luminosity. First, we show that the brightness distribution at a given mid-IR wavelength seems to be rather well described by a power law, which makes a simple Gaussian or ring size estimation quite inadequate. Here we instead use a half-light radius R_1/2 as a representative size. We then find that the higher luminosity objects become more compact in normalized half-light radii R_1/2 /R_in in the mid-IR, where R_in is the dust sublimation radius empirically given by the L^1/2 fit of the near-IR reverberation radii. This means that, contrary to previous studies, the physical mid-IR emission size (e.g. in pc) is not proportional to L^1/2, but increases with L much more slowly, or in fact, nearly constant at 13 micron. Combining the size information with the total flux specta, we infer that the radial surface density distribution of the heated dust grains changes from a steep ~r^-1 structure in high luminosity objects to a shallower ~r^0 structure in those of lower luminosity. The inward dust temperature distribution does not seem to smoothly reach the sublimation temperature -- on the innermost scale of ~R_in, a relatively low temperature core seems to co-exist with a slightly distinct brightness concentration emitting roughly at the sublimation temperature.


The purpose of this study was to determine the effect of iron sand on the K-300 concrete compressive strength. Iron sand added with a variation of 2-4% using cube-shaped specimens with dimensions of 15 × 15 × 15 cm as many as 27 samples consisting of 3 variations, each with 9 samples, concrete quality tested at 3, 7, and 28 days. The results showed the compressive strength of normal concrete characteristics at 3 days of age was 238.76 Kg / cm2, 7 days was 270.64 Kg / cm2, and 28 days was 370.16 Kg / cm2, the addition of iron sand was 2% at 3 days amounting to 192.33 Kg / cm2 with an effect of -6.11%, 7 days amounting to 262.14 Kg / cm2with an effect of -3.87%, 28 days at 314.77 Kg / cm2 with an influence of -11.8%, addition of iron sand 3% at 3 days at 207.88 Kg / cm2 with an effect of -14.65 %, 7 days amounting to 262.28 Kg / cm2 with an effect of -4.94%, 28 days at 296.64 Kg / cm2 with influenceat -16.8%, the addition of 4% iron sand at 3 days at 178.06 Kg / cm2 with an effect of -14.97%, 7 days at 236.13 Kg / cm2 with an effect of -10.3% 28 days at 264.58 Kg / cm2 with an effect of -26.2%. based on the results of the study it can be concluded that the more iron sand we use, the more there is a decrease in the concrete compressive strength


55 56 57 Anaplastic spheno-orbital meningioma: rapid growth after extensive exenteration 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 Spheno-orbital meningiomas (SOMs) arise from the sphenoid bone and extend into the orbit. These tumours account for approximately 2% of all orbital lesions. Presenting symptoms typically include proptosis, diplopia, or optic neuropathy. Most SOMs are CNS World Health Organization (WHO) grade 1 lesions. These are generally considered benign and slow growing. A small proportion of SOMs consists of CNS WHO grade 2 lesions, whereas CNS WHO grade 3 SOMs are very rarely described. These are often called malignant meningiomas. Here we present a CNS WHO grade 3 anaplastic SOM with rhabdoid, sarcomatoid, and epitheloid features that was debulked by means of exenteration. An 87-year-old male was referred for diplopia and anaesthesia along the left maxillary (V2) nerve. Past medical history included hypertension and benign prostatic hyperplasia. There was no personal history of cancer. Magnetic resonance imaging (MRI) revealed a leftsided sphenoid bone meningioma (Fig. 1A, B). The patient was deemed ineligible for neurosurgical intervention. Thus he was treated with external-beam radiation and hyperbaric oxygen therapy. Despite 2 rounds of treatment, left visual function deteriorated from 20/50 to no light perception by 5 months after initial presentation. He had progressive pain and proptosis, resulting in 6 mm of axial asymmetry. The right eye and orbit remained unaffected. Repeat MRI revealed expansion of the intraorbital soft tissue component of the tumour while the bony component remained stable (Fig. 1C, D). An incisional biopsy of the tumour was performed. Histopathology was significant for a pleomorphic tumour with increased mitotic activity and areas of necrosis. The sample was not diagnostic, however. Given continued expansion of the tumour (Fig. 1E, F) causing intractable pain, a left orbital exenteration was performed (Fig. 2). Histopathologic analysis of the exenterated tissue showed a pleomorphic tumour. Approximately 25% of the tumour cells showed rhabdoid features including vesicular nuclei, variably prominent nucleoli, eccentrically placed eosinophilic cytoplasm, and globular paranuclear inclusions. In other parts, the tumour appeared cohesive, and some tumour cells showed epithelioid features or eccentric eosinophilic cytoplasm without paranuclear inclusions. Anaplastic foci contained 22 mitotic figures per 10 high-power fields (defined as 0.16 mm each; Fig. 1C). Immunohistochemical analysis of the specimen showed positivity for SSTR2A (somatostatin receptor 2A), usually strongly positive in meningiomas, and AE1/AE3, a pan-cytokeratin stain that can be focally positive in meningiomas (Fig. 1D, F). A few tumour cells stained positive for epithelial membrane antigen (Fig. 1E). The tumour had lost expression of H3K27me3 (Fig. 1G). Nuclear expression of BAP1 and INI1 was retained, indicating the wild type of these genes. Based on histopathologic criteria, the final diagnosis was a CNS WHO grade 3 anaplastic SOM with rhabdoid, sarcomatoid, and epithelioid features. Postoperatively, the patient was placed on daily oral steroids for pain control and inflammation. There was rapid new tumour growth along his infraorbital rim, and he died 3 months later. We describe a case of a anaplastic SOM, CNS WHO grade 3, with rhabdoid, sarcomatoid, and epithelioid features as well as loss of H3K27me3 expression. The initial diagnosis of meningioma was inferred by the radiographic features on MRI. However, the diagnosis cannot be confirmed without pathologic specimens. Meningiomas show a broad spectrum of histopathologic subtypes. The histochemical markers most often used in the diagnosis of meningiomas are SSTR2A and epithelial membrane antigen. The monoclonal antibody for SSTR2A is especially helpful in establishing the diagnosis of meningioma when there is poor cellular differentiation. SSTR2A is highly sensitivity and specific for meningiomas; nearly all meningiomas express this marker. WHO grading of CNS tumours has traditionally been based exclusively on histologic features. A WHO grade 3 meningioma is defined by 20 or more mitotic figures in 10 consecutive high-power fields, wherein a high-power field measures 0.16 mm. Frank anaplastic features such as sarcomatous, carcinomatous, or melanomatous appearance also qualify as a WHO grade 3 lesion. But WHO grading of CNS tumours is no longer restricted to histologic grading. Molecular markers provide powerful prognostic and diagnostic information. The presence of a telomerase reverse transcriptase (TERT) gene promoter mutation and (or) a homozygous deletion of the CDKN2A or B gene also constitutes a tumour that is a WHO grade 3 meningioma. This case was consistent with an anaplastic meningioma, WHO grade 3, given the high mitotic rate ( 20 per high-power field) and the presence of carcinomatous and sarcomatous features. Thus no further molecular testing was performed for tumour grading. Historically, rhabdoid and papillary morphology qualified a CNS meningioma as WHO grade 3. However, up to 50% of meningiomas with rhabdoid features lack aggressive histologic features. Therefore, while papillary and rhabdoid features often are seen in combination with aggressive features, grading of these tumours is not done based on rhabdoid or papillary architecture alone. Meningiomas with rhabdoid morphology often harbour breast cancer 1 (BRCA1)-associated protein (BAP1) inactivation. BAP1-negative meningiomas have reduced time to recurrence compared with those that retain BAP1 function. Further, a subset of


This study simulates the conditions in which Botrytis may appear in a modified atmosphere packed horticulture product, such as strawberry, so as to elaborate a predictive model that could allow us to estimate the shelf-life of a contaminated food product in such atmosphere conditions (0 to 40% CO 2 ). The estimated shelf-lives obtained at 18 °C were 92, 164, and 236 h in storage atmospheres of 0, 10, and 20% CO 2 , respectively, very close to observed values; no growth was observed above 30% CO 2 . The elaborated predictive model allows us to: (a) control development of this fungi if the food product is maintained in an atmosphere containing more than 20% CO 2 and (b) predict the time taken for potential colonies to become visible (3 mm dia) and, thus, cause immediate rejection by consumers.


The aim of the study is to develop and validate a simple, precise and rapid high performance thin layer chromatographic (HPTLC) method for Cefpodoxime Proxetil and Ofloxacin in bulk and combined tablet dosage form. Chromatographic separation was accomplished by using precoated silica gel 60F 254 TLC plate (20cm x10cm) with 250μm thickness with mobile phase Chloroform in ratio methanol (9:1 v/v). Detection was performed at isobestic point 255 nm for both drugs. The retesion factor of Cefpodoxime Proxetil and Ofloxacin were found to be 0.63 and 0.25, respectively. The reliability of the method was assessed by evaluation of linearity range (500-3000 ng/spot for both Cefpodoxime proxetil and ofloxacin respectively. Accuracy (99.56 % for Cefpodoxime Proxetil and 99.33% for Ofloxacin), and specificity, in compliance with ICH guidelines.


Greenhouse gas is one of the important causes of global warming,but the source is not clear. As animals play a key role in ecosystem,the study of animals' role in greenhouse gas emission will help to further identify animals' impact on both natural material cycle and global climate change.Recently studies have revealed that animals contribute to the emission of greenhouse gas CO2,N2O,and CH4as well.


Electro-magnetic force on the in-vessel components and vacuum vessel due to the induced eddy current and halo current during plasma disruptions and vertical displacement events (VDE) imposes various constraints on the design of ITER. Careful design consideration has been given to perform a robust design against electro-magnetic force in ITER. In this paper, we present several representative cases of disruptions and VDEs calculated by the DINA code, which solves plasma transport and 2D free boundary plasma equilibrium simultaneously with circuit equations for the vacuum vessel and PF coils [1]. The cases include (i) Major disruption (thermal quench at the nominal location), (ii) and (iii) Upward and downward VDE with fast current quench. An Example of plasma evolution for the Major disruption case is shown in the figure. In the calculations of these representative cases with the DINA code, plasma characteristics such as time-averaged current quench rate under various discharge conditions, R (cm) Z(cm)


This paper presents expressions and computational graphs to determine the optimal tuning and damping parameters for a linear system with two degrees of freedem. The maFss m1 is connected to an immovable foundation through a spring k1 and a dashpot c1. An impressed harmonic force acts on the mass m2. Either of the masses (named main mass) should be isolated from the vibration originating from the impressed force ; whereas, the other mass functions as a dynamic absorber. The optimization criterion is minimizing the maximum displacement of the main mass. The optimal design parameters can be formulated when c1=0. If c1≠0, optimization is carried out using numerical analysis, such as the Newton-Laphson method. The optimal conditions obtained theoretically are summarized in graphs, and tested on a vibratory model. The experiment makes is clear that the theory is very useful for the isolation of actual mechanical vibrations.