Given the issue of balanced socio-economic development of the entire territory of the Kaliningrad region, an important task is to improve the quality of life in small towns in the region, as they serve as supporting elements for the regional settlement frame. Attracting federal and extrabudgetary funds could be seen as an effective tool in the context of a local budget deficit. To date, improving the quality of urban spaces has been possible due to participation in the all-Russian competition for the best projects for creating a comfortable urban environment, which has been held since 2018. Having accumulated competencies in working on competitive project applications, and participating in numerous cross-border cooperation programs, Kaliningrad group actively and very effectively join in this competition, which has already changed the quality of the urban environment. Many small towns of the Kaliningrad region are on the list of federal leaders among the places with the most comfortable urban environment. This circumstance directly improves the possibilities of such cities in attracting investors, maintaining high-quality labor resources and the possibility of expanding their own regional socio-economic specialization.


p-Nitrophenol (PNP) is an important pesticide intermediate, which is also a water pollutant that is extremely harmful to personal health. It can be converted to p-aminophenol (PAP) through selective catalytic...


—Multi-echelon transaction is a common situation in the supply chain nowadays. This research is to formulate a three-echelon integrated inventory model under defective products, reworking and credit period consideration. In order to deal with the uncertainty of demand in real life, we consider fuzzy demand in the integrated model by using fuzzy theory. An algorithm and numerical analysis are used to observe the effect of fuzzy demand to the inventory policy and total profit.


Poly(methyl methacrylate) (PMMA) and three kinds of crosslinked PMMA were synthesized by bulk polymerization.Capacitivetype humidity sensors were prepared with PMMA and crosslinked PMMAs films respectively.The electrical capacitance of the sensors changed linearly with the relative humidity over the range of 10%90% RH.The crosslinked PMMA has positive temperature coefficient.When compared with the cellulose acetate butyrate(CAB) sensor,however,the temperature dependence of PMMA is less.Crosslinked PMMA sensor is resistant to organic vapour.After exposure to saturated acetone vapour for 30min,the electrical capacitance of the sensor changed ca 1% at 90% RH after three measurement cycles.Under various severe conditions,e.g.hightemperature,highhumidity,oil vapour ect.,the sensor showed about 2% RH drift after the tests.


Context. Pulmonary hypertension is a common clinical problem encountered in day-to-day practice. Drug therapy forms the backbone of management and appropriate drug selection is based upon the underlying causes. The options available are widening with availability of newer therapeutic agents and thus it becomes necessary to be updated with the recent developments. Objective. To review the existing data regarding the efficacy, tolerability and superiority of current drug options for pulmonary hypertension on the basis of the existing data and to provide an approach to manage a patient with pulmonary hypertension. Data Sources. A thorough search of the MICROMEDEX database, updated version of June 2004 was performed. The search also included the Iowa Drug Information System (IDIS), updated version of September 2003 search for relevant trials. Additional trials from MEDSCAPE were also included. A manual search of journals was also performed for indigenous studies done on the related area. Study Selection and Data Extraction. Search terms included pulmonary hypertension, newer drugs for pulmonary hypertension, secondary pulmonary hypertension and specific drug category. Studies were selected if efficacy, tolerability and superiority were reported as major outcome measures. The preference was given for the studies, which compared the superiority of drug(s) with that of other ones either with in, or different categories. Data Synthesis. Five categories of drugs were located with the exception of the miscellaneous ones. Each category had its own merits and demerits. Only prostaglandin analogs are available in the oral form and offers patient friendliness. There were no large randomized trials comparing the effects of these agents in large patient population. There were no placebo-controlled trials prior to 1999. There are few studies evaluating the long-term efficacy of the drugs mentioned so far and their effects on survival. However, these drugs appear promising. Conclusions. The current options for the drug therapy of pulmonary hypertension are increasing and the newer drugs show promising effects in the management of pulmonary hypertension.


Abstract Throughout the past decade, scoured bridges in Taiwan have frequently collapsed as a result of heavy rainfall during typhoon seasons. To mitigate the bridge damage caused by scouring, an improved warning system is required. Three fundamental parameters including the water level, the flow velocity, and the scouring depth (SD) are significant for the structural safety of a scoured bridge. Nowadays, these parameters can be successfully detected by advanced monitoring instruments and serve as a database for a damage assessment system to carry out the function of early warning. Therefore, this article aims at developing the damage assessment system for scoured bridges as the core of a warning system. We have proposed an analytical process as an assessment system. Through finite element analysis with respect to water level and flow velocity, the critical scouring depth with a specific degree of safety factor for a bridge foundation can be determined by choosing among different failure modes. Accordingly, the relationships between various possible sets of water levels, flow velocities and critical SD are established to present the surfaces of structural safety corresponding to different levels of safety factor. The surfaces obtained can then be applied to the warning system. Based on the proposed assessment process, the collapse of the Shuang-Yuan Bridge caused by Typhoon Morakot in 2009 is discussed in detail. The consequence of bridge collapse is reasonably explained by the analytical surfaces of structural safety based on the reported parameters at the bridge site. In addition, the Dia-Jia-Hsi Bridge, which has implemented advanced monitoring instruments serves as the second case study. The surfaces of structural safety obtained have been used in conjunction with real-time observations of sensitive parameters to display the situation of structural safety at any time. The results obtained in this article benefit bridge engineers, giving a safety-management platform to speed up the decision making process during an emergency.


: Educational system in Republic of India has been bone to the Indian society. The condition out of doors activity has been stopped by the parent's thanks to the study pressure on them. Physical activity has been reduced and also the students ar still looking forward to love and affectionateness of there folks. The positive and downside of the academic system and that they points of the scholars. The support of examination is positive or not position of associate examination of every individual person.


Looking at fan fiction writing as a personally meaningful activity, this paper covers the preliminary stage in developing a model to look at this creative activity based on extant document experience literature and models. Initial data analysis points to the importance of the social context in which the activity takes place, highlighting the role that social ties in the form of fellow readers play in the process. Exploratory in nature and coming as a byproduct of data analysis, it is hoped this will aid conceptual development in information and document experience, while adding to studies that look at personally meaningful information activities.


Cloud computing has become a recent trend in the software industry due to its advantages like flexibility, efficiency, manageability and many others. Though many advantages are there in the cloud, it has its own security concerns. In the proposed scheme the following security concerns in the cloud are to be addressed access control, data privacy and also identity privacy. Most of the research work concentrates mainly on data confidentiality and access control whereas less attention is paid to identity privacy. So hereby we propose a decentralised scheme with fine-grained access control to the data stored in the cloud. Data confidentiality is achieved with CP-Attribute Based Encryption Scheme and for Identity Privacy and Access Control a decentralised scheme has been proposed which ensures higher rates of security and user identity privacy.


Couple models are a standout amongst the most encouraging ideas towards prevalent power transformation efficiencies of natural sun based cells. An exact assurance of the power transformation productivity requires rectification of the otherworldly confuse and in this manner depends on precise outer quantum effectiveness (EQE) spectra. Because of the arrangement association of 2 sub cells in the pair design, the EQE of the couple sun powered cell repeats the EQE of one sub cell if a fitting inclination light is picked to specifically enlighten and henceforth forward predisposition the other sub cell. The subsequent inner voltage drop is then repaid by applying an outside voltage to the pair sunlight based cell. In this work, we use impedance spectroscopy to precisely foresee the base predisposition light force and the outer voltage to empower exact EQE estimations on both sub cells. We embody this method on natural couple sun oriented cells involving frightfully integral safeguards and recommend an all-inclusive convention for future estimations of the EQE


In this note we present a brief history of SEIO, the Spanish Society of Statistics and Operations Research. We also explain its functional structure and other relevant features of its current life.

Keywords:

SEIO;
history;
conferences;
journals;
statistics;
operations research


Since the banking industry relies so heavily on strong customer-staff interactions, measuring employee job satisfaction has become a critical problem. To achieve benefits for both individuals and organizations, it is crucial to foster and ensure employee job satisfaction. The main objective of this study is to determine the influencing factors of employees' job satisfaction in commercial banks in Bangladesh. This study focused on some significant factors such as employee empowerment, job security, management support, and attractive compensation in an organization. In terms of research purpose, non-probability convenience sampling has been used, and the study is quantitative in nature. For data collection purposes, an online survey questionnaire was prepared based on previously published articles. The targeted population was the bank employees of commercial banks in Bangladesh where the final sample size was n = 200. For analyzing the collected data, SPSS 26.0 version has been used to test the study model and the proposed hypotheses. This study also shows that employee empowerment, job security, management support, and attractive compensation have positive and significant effects on employees' job satisfaction at the workplace. Finally, this study has offered some extraordinary directions and implications for future research on commercial bank authorities in Bangladesh.


The paper presents the data of veterinary-sanitary assessment of the Lena sturgeon grown using the nutrient feed additive Akwa-Biot-Norm. It has been revealed that organoleptic characteristics of fish samples correspond to the benign products. The chemical composition of the muscle tissue of the experimental and control groups of fish was almost the same. The cadmium level in both fish groups was 0.007 mg/kg; the mercury level was 0.00019 mg/kg and 0.00018 mg/kg in the control and in the experimental group respectively, which does not exceed the maximum permissible concentrations. Microbiological studies of Lena sturgeon meat have shown that the number of mesophilic aerobic and facultative anaerobic microorganisms (NMAFAnM) in fish samples does not exceed the safety requirements and nutritional value of food products. Coliform bacteria (BGKP), Staphylococcus, Salmonella, and Listeria monocytogenes were not isolated from all selected samples (control and experimental). The results of the veterinary-sanitary assessment of the Lena sturgeon grown with the use of the nutrient feed additive Akwa-Biot-Norm indicate that the fish meets the requirements of the technical regulations of the Eurasian Economic Union "On the safety of fish and fish products" (EEU TR 040/2016) and is safe for the consumer.


This paper takes a novel approach to the problem of characterising electrical ageing in solid dielectrics through ex-situ experiments that seek to reproduce the chemistry of electrical treeing in bulk. Plaque specimens of a range of polymers, including polyethylene, polystyrene, polyether ether ketone and silicone rubber, were subjected to surface ageing via corona discharge in air or in a closed cell where the atmosphere can be controlled and adjusted. The residual products on both the sample surface and the high voltage electrode were characterised by Raman microprobe spectroscopy and the resulting fingerprints were compared with those previously identified within electrical trees. Analysis of the electrodes aged in air and nitrogen revealed varying evidence of sp2 hybridized carbon, and fluorescence, both of which are products previously associated with the processes involved in electrical treeing. The significance of the results is discussed with respect to electrical treeing.


WHEN SHEAR AND MOMENT ARE KNOWN, THE CORRECT NUMBER OF BOLTS NEEDED IN A WEB SPLICE CAN BE QUICKLY CALCULATED. THE CURVES SHOWN HERE ARE FOR BOTH AASHO SPECIFICATIONS AND AMERICAN INSTITUTE OF STEEL CONSTRUCTION SPECIFICATIONS.


3.3. Other Heterogeneous Catalysts 2428 3.3.1. Chromium-Containing Molecular Sieves 2428 3.3.2. Supported Gold 2428 3.3.3. Supported Multi-Metals 2429 3.3.4. Supported Iron Oxide 2429 3.3.5. Polyoxometalate 2429 3.4. Enzyme Catalysis 2431 3.5. Photocatalytic Oxidations 2431 4. Aerobic Oxidation of Phenols 2432 4.1. Cobalt Complex Catalysts 2432 4.2. Enzyme Catalysis 2434 5. Oxidation of Alkenes 2434 5.1. Metal Complex Catalysts 2434 5.1.1. Molybdenum-Based Catalysts 2434 5.1.2. Vanadiumand Titanium-Based Catalysts 2436 5.1.3. Palladium(II) Chloride 2436 5.1.4. Iron-Based Catalysts 2438 5.1.5. Manganese-Based Catalysts 2440 5.2. Supported Metal Catalysts 2440 5.2.1. Catalytically Active Wall of a Stainless-Steel Reactor 2440


Abstract Rainbow smelt Osmerus mordax introduced into the Great Lakes watershed (Crystal Lake, Michigan) in about 1912, began colonizing the Great Lakes in the 1920s. The species now is found throughout much of the Great Lakes watershed of Ontario and in the Mississippi–Missouri drainage as a result of inadvertent or intentional introductions. Gill-net and trawling surveys in 1989 and 1990 of 79 lakes (92 separate times or sites) in the Winnipeg River system of the Hudson Bay drainage in northwestern Ontario, southeastern Manitoba, and northeastern Minnesota revealed or confirmed the presence of rainbow smelt in 19 lakes and extended the species' known range in the Rainy, English, and Wabigoon river systems. Rainbow smelt also were discovered in Lake Winnipeg late in 1990 and in Lake of the Woods in early 1991. Elsewhere, the establishment of rainbow smelt in new water bodies often has been associated with changes in native fish populations. The potential now exists for further spread of rainbow smelt in ...


The stakeholder co-operatives formed around the town of Mondragon in the Basque region of Spain have been outstandingly successful on a number of measures in comparison with other forms of firms. The control architecture within and between Mondragon firms contains a number of innovations and lessons for developing the theory and practice of corporate governance. This paper outlines the 38 year evolution of Mondragon structures.

The control and incentive architecture of Mondragon firms was custom designed according to the nature of both their activities and their principal stakeholders. The resulting unique control arrangements and outstanding performance supports the hypothesis that the structure of governance is a determinant of sustainable competitive advantages. The evolution of Mondragon firms also illustrates the need to consider corporate architecture as a variable at any one time or over time. The Mondragon experience illustrates how the social research approach of 'action science' can be used to create competitive enterprises. The paper recommends this approach for developing the theory and practice of corporate governance.


Types of Molecular Energy:(i) The transition energy (Et) due to the translational motion of the molecule. (ii) The electronic energy (Ee) since the electrons associated with each atom (or) bond are in continuous motion. (iii) The vibrational energy (Ev) due to the periodic displacement of its atom from their equilibrium position. (iv) The rotational energy (Er) by virtue of bodily rotation about its atom centre of gravity. I Born and Oppenheimer, the various form of energies of a molecule are independent of each other.


The utility model discloses a turbine rotor energy-saving engine which is a cylindrical machine body. A rotating shaft is arranged in the center of the cylindrical machine body, a rotor is arranged on the shaft, the rotor is sleeved with a cylinder shell, an air pressing fan is arranged at one end of the rotating shaft, the rotor is divided into an upper cylinder rotor, a middle cylinder rotor and a lower cylinder rotor, the corresponding machine body shell is divided into an upper cylinder, a middle cylinder and a lower cylinder, the upper cylinder rotor is a star-shaped equal-arc cam, three sets of piston air cylinders and three sets of high-pressure oil pumps of the body shell of the upper cylinder are correspondingly and longitudinally equal in distance and are compressed to carry out reciprocating motion, three protruding pistons in the middle section of the rotor are matched with the inner wall of the cylindrical middle cylinder to be in sealing rotation, the protruding pistons and the shaft are identical in direction and equal in arc length, radial sealing grooves are formed in the inner wall of the middle cylinder in an equal-arc mode, groove sealing pieces divide the body of the middle cylinder into three sets of independent cylinder bodies, each set of cylinder body is provided with an ignition chamber to be communicated with the middle cylinder and is provided with a sparking plug and an oil nozzle, two auxiliary cylinders are arranged on the inner layer of the wall of the middle cylinder to be communicated with the middle cylinder, new energy fuel is combusted in one auxiliary cylinder, cooling water absorbs heat and is gasified in the other auxiliary cylinder and returns to the middle cylinder, and the excess pressure of discharged waste gas is reused by the lower cylinder rotor to carry out circulating acting to improve heat efficiency. The turbine rotor energy-saving engine is simple in structure and small in size, saves energy and is environmentally friendly.


Uranium concentrations and oxidation states were determined on 45 samples from the Campanian Zefa phosphorite field in southern Israel. Optically anisotropic bone fragments have the lowest uranium concentration of all apatitic grains in the rock (80-150 ppm). Replaced isotropic bones are richer in U (120-260 ppm), as are isotropic ovulites (140-300 ppm). Nonapatitic grains and calcitic matrix and cement are U poor (usually less than 5 ppm). The ratio between U concentration in isotropic and anisotropic components in any rock is nearly constant around 1.6. The U/P/sub 2/O/sub 5/ ratio in a sample depends on the uranium concentration in all grains rather than on the abundance of various grain types. U(IV)/U varies in the range of 15 to 54 percent of the total U. The ratio of U(IV)/U for the Zefa deposit falls in the field of onland phosphorites. The dispersion of the U/P/sub 2/O/sub 5/ ratio among samples within each columnar section of the Zefa field is similar to the dispersion of the average U/P/sub 2/O/sub 5/ ratios among the six columnar sections and is not different from the dispersion of that ratio between different phosphate deposits in Israel. The above results are compatible with accepted models of phosphoritemore » formation, according to which organic matter serves both as a phosphorus-contributing and uranium-concentrating phase.« less


This chapter discusses how the 5-year survival rates for the most common cancers in the United States improved by nearly 20% since the 1970s. While promising overall, low survival rates persist for pancreatic, liver, lung, esophageal, brain, and many other cancers. Meanwhile, 5-year survival for uterine and cervical cancers worsened. Pancreatic cancer has the lowest 5-year survival rate at 8.2%. In contrast, prostate cancer had the greatest 5-year survival increase from 67.8% to 98.6%, most likely reflecting a substantial uptick in prostate cancer screening and early detection. Five-year survival with leukemia also improved significantly, from 34.2% to 60.6%, likely resulting from improved treatments. As such, in both detection and treatment, the United States is making progress. For the millions of Americans who face a cancer diagnosis, this is cause for hope.


Objective To explore the environmental and behavioral factors related to childhood obesity,and provide scientific evidence for developing preventive strategy. Methods 9 356 children aged 4~16 years old were selected from Guangzhou,Shanghai,Jinan and Haerbin with multi stage cluster random sampling method and investigated with questionnaires.Their body weight and height were measured following standard procedure. Results The average prevalence of obesity was 11.9% in four cities.Obesity was more prevalent in boys than in girls;Obesity prevalence was higher in Northeast,urban and high income families.The more frequent the children skipped breakfast and consumed fast food,the higher the obesity prevalence was.The longer the children watched television,the higher the obesity prevalence was. Conclusion Prevalence of obesity among children in urban China has reached the epidemic level.Domicile region,socioeconomic status,eating practice,television viewing time and behavioral factors affected the obesity prevalence


Facing the austerity situation of the 9th sports game, showed requires of the ideological and political work on the basis of the effect in the last year.


Inquiry-based education has long been used to teach science-based and technical subjects. However, problems often arise during the process of implementing this educational concept into school practice. One cause of this problem may be a lack of development of substantial competences: educational theory does not yet provide a generally valid competence framework, except in a few limited studies. This problem causes difficulties during teachers' initial and life-long education and is the primary motivation for our research. Based on our results, we created a competence model for identifying the key competences for realizing inquiry-based education may be concluded. In the first phase, published research conclusions connected to the competences of teachers of science-based and technical subjects—accentuating inquiry-based education—were analysed. Accordingly, we conducted research that helped both to establish the importance of individual competences and (subsequently) to create the competence model. The Q-methodology was used for the purpose of obtaining data, and statistical methods (e.g., Cronbach's alpha, split half, chi squared and Spearman's correlation coefficient) were used for the purpose of evaluating that data. The research took place in the Olomouc region of the Czech Republic, with 54 expert teachers (from basic schools) participating.


Introduction: The utility of ultrasound scans for thoracic conditions is nowadays demonstrated. It has a series of advantages over other imaging techniques, which include the absence of ionising radiation, the possibility of bedside exploration without moving the patient, real-time assessment and equipment accessibility. These advantages make it the study of choice for guiding minimally-invasive procedures in several thoracic conditions, thus achieving the management of outpatients, avoiding hospitalizations or conventional surgical interventions, and therefore minimizing health system costs. Objective: Highlight the role of ultrasound scans and of minimally-invasive methods for the various thoracic conditions. Design: Retrospective, observational, descriptive study. Material and method: Bibliographic review and assessment of patients treated in Thoracic Surgery Service. Results: Between January 2011 and March 2012, 19 ultrasoundguided thoracic minimally-invasive procedures were carried out. Four cases were for percutaneous catheter placement due to partitioned pleural collections, five cases of diagnostic thoracentesis in minimal effusions, four cases of biopsy with Abrams needle or Tru-Cut; and in six cases, fine-needle and core-needle surgical punctures carried out due to peripheral mediastinal and lung tumors. All patients were operated on in the operating room, with local anesthesia, and cardiologic monitoring. No procedural complications were registered. Conclusions: Ultrasound-guided interventions are a valuable tool


The LE-X is a new cryogenic booster engine with high performance, high reliability and low cost, being designed for the next-generation Japanese launch vehicle. Following an early- stage feasibility study, detailed studies focusing on front-loading design approaches were conducted in 2006 and 2007. An optimum engine system was determined and potential risks were mitigated by various element tests. These activities will lead to the realization of the first booster engine in the world with expander cycle.


Myofibrils are long intracellular cables specific to muscles, composed mainly of actin and myosin filaments. The actin and myosin filaments are organized into repeated units called sarcomeres, which form the myofibril cables. Muscle contraction is achieved by the simultaneous shortening of sarcomeres and for a highly coordinated contraction to occur all sarcomeres should have the same size. Muscles have evolved a variety of ways to ensure sarcomere homogeneity, one example being the controlled oligomerization of Zasp proteins that sets the diameter of the myofibril. To understand how Zasp proteins effect myofibril growth, we looked for Zasp-binding proteins at the Z-disc. We found that the E1 subunit of the oxoglutarate dehydrogenase complex is recruited to the Z-disc by Zasp52 and is required to sustain myofibril growth. By making specific mutants, we show that its enzymatic activity is important for myofibril growth, and that the other two subunits of the complex are also required for myofibril formation. Using super resolution microscopy, we revealed the overall organization of the complex at the Z-disc. Then, using metabolomic analysis, we uncovered an amino acid balance defect affecting protein synthesis, that we also confirmed by genetic tools. In summary, we show that Zasp controls the local amino acid pool responsible for myofibril growth by recruiting the OGDH complex to the Z-disc.


The pure ultrafine silver powders were prepared by a apparatus with high-vacuum,two-torches DC arc plasma,which is self-designed and manufactured for continuous nano-scale metal powders preparation.Effects of parameters on output and granularity distribution were studied by orthogonal test.The chemical composition,morphology,crystal structure and the granularity distribution were characterized by X-ray diffraction(XRD),transmission electron microscopy(TEM) and selected area electron diffraction(SAED) and Simple PCI software.The results show that the ultrafine silver powders are pure without pollution and polygonal crystals;the average size is in the range from 38 to 220 nm;the maximum output is increased by 17 times compared with that of similar reaseach;The current and gas pressure are the significant factors to affect output and granularity distribution respectively.


The constant and significant increase of computer power at low cost and many recent major technological
advances in program properties verification techniques show that designers and developers can now efficiently
and practically use proving techniques either at model or source code level.
Those new V&V techniques convey major benefits to industrial sectors where software quality is at stake including
early detection of errors (at specification, design and coding levels), and proof of absence of errors. Those
techniques strengthen software application development process and minimize the likelihood of errors found
either late or released in the field.
The paper describes several advanced techniques for statically verifying dynamic properties of programs
including logical, functional, run-time errors, how those techniques fit within current development processes and
how they may be used for monitoring software quality over time. The paper primarily applies to the development
of embedded applications and demonstrates how the combined usage of techniques such as model-checking and
abstract interpretation effectively handles industrial problems today.


1. GENERAL INTRODUCTION 1 Prologue: Forgotten transmission 1 1.1. Malaria epidemiology: a global problem 2 1.2. Control failure 1.3. Unravelling malaria evolutionary ecology 5 1.3.1. A complex life history 5 1.3.2. An undetected pest 8 1.3.3. Hidden diversity 9 1.3.4. The ecology of mixed infections: competition has its hay-day 10 1.3.5. The missing link: transmission 12 1.4. A note on rodent malaria as a model system 14 1.5. Experimental Aims 16 2. REVERSE TRANSCRIPTION PCR (RT-PCR) FOR THE DETECTION AND QUANTIFICATION OF TRANSMISSION STAGE MALARIA PARASITES 17 2.1. Abstract 17 2.2. Introduction 18 2.3. Materials and Methods 19 2.3.1. P. chabaudi infections 19 2.3.2. DNA extraction 20 2.3.3. RNA extraction 20 2.3.4. PCR and RT-PCR 21 2.3.5. Detection limits of PCR and RT-PCR 23 2.3.6. qRT-PCR 23 2.3.7. Validation of qRT-PCR 24 2.4. Results 26 2.4.1. Detection of P. chabaudi infection and gametocytes 26 2.4.2. Persistence of P. chabaudi asexuals and gametocytes from longevity experiments 28 2.4.3. qRT-PCR 32 2.5. Discussion 34 3. TRANSMISSION IN CHRONIC MALARIA INFECTIONS 37 3.1. Abstract 37 3.2. Introduction 38 3.3. Methods 40 3.3.1. Parasite, host and vector 40 3.3.2. Assessment of in-host and transmission dynamics 40 3.3.3. Statistical analysis 43 3.4. Results 43 3.4.1. Dynamics from all mice harbouring acute or chronic infections 44 3.4.2. Dynamics from mice infectious to vectors 47 3.5. Discussion 50 4. TRANSM1ISSON IINVESTMENT OF MALARIIA PARASflIES FN RESPONSE TO INHOST COMPETITION 54 4.1. Abstract 54 4.2. Introduction 55 4.3. Methods 57 4.3.1. Parasites and hosts 57 4.3.2. Monitoring infection dynamics 58 4.3.3. Statistical analysis 61 4.4. Results 62 4.4.1. Disease severity 62 4.4.2. In-host asexual and sexual densities 62 4.4.3. Transmission investment in relation to total parasite production 66 4.5. Discussion 70 5. COMPETITIVE FACIUTATION OF DRUG R1ESIISTANCE IN MXEI1) CLONE MALARIA INFECTIONS 72 5.1. Abstract 72 5.2. Introduction 73 5.3. Methods 75 5.3.1. Parasites and hosts 75 5.3.2. Drug treatment 76 5.3.3. Monitoring infection dynamics 78 5.3.4. Statistical analysis and trait definition 78 5.4. Results 79 5.4.1. Virulence 79 220.127.116.11. Experiment I 79 126.96.36.199. Experiment II 80 5.4.2. Parasite growth dynamics 83 22.214.171.124. Experiment I 83 126.96.36.199. Experiment II 86 5.4.3. Transmission investment 92 184.108.40.206. Sensitive clone 92 18.104.22.168. Resistant clone 92 5.5. Discussion 94 GENERAL DISCUSSION 98 6.1. Should we care about gametocytes? 98 6.2. What about mosquitoes? 100 6.3. Is qRT-PCR a good method? 101 6.4. Impact of findings on human malaria epidemiology 103 6.5. A few burning questions 106 6.6. Concluding remarks 108


In this study EN-AC 43200 Aluminum alloy was subjected to secondary or interrupted aging following a T6 heat treatment. The 43200 alloy is a used widely in automotive industry for lowering weights of vehicles by substituting with ferrous alloys. This study covers the substitution of an automotive company's part. 4320 Al alloy was melted under Argon atmosphere with an induction furnace, and cast into graphite molds. The samples were homogenized at 500 oC for 96 hours. Solutionizing treatment also done at 500 oC for 14 hours, following water quenching, T6 treatment was done at 250 oC for 2 hours ended with a water quench. Secondary aging trials were done at 100, 150 and 200 oC for 2, 4, 6 and 8 hours for each temperature range respectively. Tensile tests and microhardness tests were applied to for cast, T6 condition, and secondary aged samples. The samples were polished and observed for microstructure under optical microscope. Maximum strength value of 370 MPa, and hardness 113 Hv was obtained from samples aged secondarily at 150 oC for 6 hours.


Abstract : A heat flux measurement system comprising a laser diode, a single mode optical fibre interferometer and passive optical fibre components has been constructed. The system has been designed for use in transient flow wind tunnels and has a resolution of 1 kWm/sq meter, a dynamic range of 20 MW m/sq meter and bandwidth > 100 kHz. Heat flux measurements have been made with the system on the endwall of a cascade of stator blades. Optical fibre, Heat flux.


Background and purpose: Scorpion sting is one of the major health problems of undeveloped countries, which causes severe complications and so metimes death. This study aimed to assessment Knowledge of scorpion sting patients who admitted to Ahvaz Razi Hospital, Iran, about pre-hospital care. Materials and Methods: This is a descriptive study, which its participants were sampled by a pilot method, and the sample size was estimated equ al to 100 based on the formula. For this study, the tools for collecting the data were a que stionnaire of demographic data, including nine questions and a researcher-made questionnaire relat ed to the knowledge level of the patients about pre-hospital cares consisting of 12 questions . After collecting, the data were entered them into SPSS software. Then, the data were analyzed us ing the descriptive statistics including frequency and analytic statistic chi-square . Results: The data of the present study showed that the highe st rate of scorpion-sting had been in women. In addition, most stings occurred inside the home and in the city. The most cases (80%) did not have knowledge about first aids to the inju red person also about the use of tourniquet most cases (70%) have low knowledge. Conclusion: Considering the low knowledge of the injured peopl e about the pre-hospital actions, it seems necessary for the society to be e ducated adequately about this issue to prevent the adverse outcomes such as amputation of an organ because the incorrect use of tourniquet, death of the injured person due to lack of knowledg e about first aids. [Rokhafroz D, *Sayadi N, Rahmani H. Knowledge of Scorpion Sting Patients who Admitted to Ahvaz Razi Hospital, Iran, about Pre-hospital Care . Iran J Health Sci 2015; 3(4): 47-51] http://jhs.mazums.ac.ir


Nowadays, the transportation industry is heavily-incessant research and development on a train with a magnetic drive which is also called maglev trains. Magnet has two poles, the North (N) and South (S). We know that North and South poles always attract, while similar poles (North or South to North with the South) always repel. This train has a rail (track) that are different train tracks we already know all this. On both sides of the maglev railway tracks have walls that are equipped with a coil-coil wire. By the principle of electromagnetic induction, coil-coil wire can be a magnet. So the basic principle of this maglev train is to take advantage of the magnetic lifting force on the rails so that lifted slightly upward, then the thrust generated by the induction motor. This train can move forward because of the interaction between the magnets on the wall with the magnets on the train, and is capable of driving trains at speeds up to 650 km / h (404 mph), which is much faster than regular trains.

In this final attempt to give an idea of the design and modeling of the maglev train. In the design and modeling is closely related to the magnetic field, electromagnetic induction from the coil.


Place attachment is a common expression used by individuals to identify with natural settings. Although resource meanings are hard for some people to describe, intangible values can play an important role in site visitation. The purpose of this study was to measure the effect of interpretation on place attachment; a relationship that has been speculated, but not tested. A questionnaire was administered to nearly 200 visitors who attended a wild cave tour at a state park in mid-Missouri. Results indicated that the naturalist-led program was successful, but the place attachment scores were similar before and after the tour. However, visitors who attended cave tours frequently scored higher on place attachment than first-timers. Results of this study are discussed in relation to cognitive map theory.


Using the International Best Track Archive for Climate Stewardship (IBTrACS) dataset, this study assessed the surface wind fields from high spatial resolution Synthetic Aperture Radar (SAR) observations, the fifth generation ECMWF reanalysis for the global climate and weather (ERA5) data and the Tropical Cyclone Winds and Inflow Angle Asymmetry (TCIAA) wind model. The results showed that SAR data are sufficient to reveal the surface wind field near a TC center and can accurately describe TC intensity and size under severe TC conditions. Then, a new, improved statistical wind structure model was set up using ERA5 data alone based on the assessment. In addition, the warm sea surface (SST > 26.5 °C) produced stronger TC wind fields and heavier precipitation. When the SST was higher (lower), the heavy rainfall was located on the left (right) side of the TC track and the strong positive correlation between wind speed and precipitation increased as the SST decreased.


Abstract : In 1992, Aircraft Research and Development Unit (ARDU), RAAF, experienced two misfires with Rocket Motors, 3 in., No. 1, Mk 4, during a series of firings at Woomera. These motors were sampled from a batch manufactured in 1957, and subsequent to the misfires this batch was withdrawn from use. An alternate batch of motors manufactured in 1966 was available to ARDU. Tests were conducted on a number of these motors to advise on their suitability for use, and as a result, a further five years life was assigned with a recommendation to retest after that period. Rocket motors, Ballistic testing, Igniters, Static firing tests, Thrust


ABSTRACT: In this study, the possibility of measuring rock surface roughness by means of opensource photogrammetric methods was investigated. With simple commercially available digital cameras, samples of varying roughness were measured. As a reference, the samples were also measured with a high-resolution white light strip scanner and additionally manually with a contour gauge. By comparing the digital datasets it became clear that the open-source structure-from-motion (SFM) algorithms were able to capture the overall topography but with clearly less accuracy than the white light scanner. This had a marked influence on the determined roughness parameter JRC (joint roughness coefficient). For smooth surfaces the JRC was higher than the reference value, for rough surfaces it was lower. In general, with the introduced method it was possible to reproduce the surface of the rocks but care has to be exercised when roughness parameters are to be deduced from the datasets.


SUMMARY In the eastern part of Nebraska, schools received a state grant to build a two-way audio-video network for the purpose of improving student skills in technology. A few network teachers were trained and earned Microsoft Office User Specialist (MOUS) and Windows NT certification. These skilled instructors then trained others and developed a team approach to offer computer networking and Microsoft Office courses to students in 8-11 small districts in the region. At the conclusion of the Office courses, a randomly selected group of students took the MOUS exams with favorable results. The distance system's management team has given careful consideration to the complex management issues and appropriate incentives for teachers which has resulted in high performance that may not otherwise have been possible.


AbstractI presented the Kenneth L. Lee lecture at the 2016 Queen Mary Seminar, ASCE Los Angeles Geo-Institute Chapter, and publish it herein. The topic was lateral spread problems I have encountere...


Introduction: Psoriasis is a chronic, relapsing, cutaneous disease affecting about 2-3% of the world's population and presents as erythematous, indurated, scaly plaques over the skin with involvement of nails and joints in some cases. Although psoriasis is not a life threatening disease, but the quality of life is severely affected and there is still no curative treatment. Many patients also have associated stress, depression and anxiety related problems. Aim of the study: To study the role of stress, anxiety and depression in development of psoriasis, to study the histopathological changes in psoriatic skin biopsies and serum serotonin levels in psoriasis. Materials and Methods: A total of 27 cases of biopsy diagnosed psoriasis cases and 27 controls were studied for clinical presentation, microscopic findings, for stress, depression and anxiety indices. The serum serotonin levels of psoriasis cases were compared with age and gender matched non-psoriatic healthy control individuals. Results: The patient age ranged from 17 to 55 years and there was a male predominance with male to female ratio of 3.5:1. Psoriasis was more common in the fourth and fifth decades. Psoriasis vulgaris was the most common clinical presentation. Consistent biopsy findings in most of the cases were presence of parakeratosis, dilated capillaries, elongated rete ridges with blunted edges, hypogranulosis and regular acanthosis. All three indices showed mean value signifying a Moderate degree of perceived stress, depression and anxiety in psoriasis group. The difference between serum serotonin levels in the patient group and control group was highly significant. Conclusion: Psoriasis is a chronic skin disorder affecting young to middle people and is more common in males. Psoriasis vulgaris was the most common clinical presentation. Consistent biopsy findings in most of the cases were presence of parakeratosis, dilated capillaries, elongated rete ridges with blunted edges, hypogranulosis and regular acanthosis. These patients are more likely to have mild to moderate degree of perceived stress, depression and anxiety. Many patients with psoriasis have elevated serum serotonin and are also likely to have depression. Prescription of serum serotonin reuptake inhibitors (SSRIs) has to be done cautiously in these patients.


An immersion lithographic apparatus provides an immer sion liquid including photosensitive material(s) configured to form a patterned film on the surface of a substrate on exposure to a radiation beam. Irradiation through the immer sion liquid onto a Substrate leads to deposition of a film on the substrate. Film formation occurs only in the photoirra diated region, so that the film formed has a pattern corre sponding to the pattern of the radiation. Patent Application Publication Sep. 20, 2007 Sheet 1 of 3 US 2007/0216883 A1 Patent Application Publication Sep. 20, 2007 Sheet 2 of 3 US 2007/0216883 A1


A convenient and efficient iron‐catalyzed nucleophilic addition of simple alkenes to isochroman acetals has been established for the synthesis of 1‐alkenyl isochromans. In the presence of 5–20 mol % iron(III) p‐toluenesulfonate, the alkenyl functionalized isochromans were prepared in moderate to excellent yields. This transformation provides a novel methodology for the synthesis of 1‐alkenyl isochromans from simple alkenes and isochroman acetals.


If the phase error at each pixel in a complex-valued MRI image is known the noise in the image can be reduced resulting in improved detection of medically significant details. However, given a complex-valued MRI image, estimating the phase error at each pixel is a difficult problem. Several approaches have previously been suggested including non-linear least squares fitting and smoothing filters. We propose a new scheme based on iteratively applying a series of non-linear filters, each used to modify the estimate into greater agreement with one piece of knowledge about the problem, until the output converges to a stable estimate. We compare our results with other phase estimation and MRI denoising schemes using synthetic data.


A third order elliptic log-domain filter, fabricated in 0.35 /spl mu/m CMOS technology, is presented. Lateral bipolar transistors inherent to standard CMOS processes and strongly-inverted MOSFET transistors have been used in this work to map traditional bipolar circuitry into CMOS technology. Experimental measurements demonstrate, that bandwidths of up to 10 MHz and dynamic ranges on the order of 40 dB can be achieved using these devices, and that both poles and zeros can be accurately placed using the described design techniques. Log-domain filters based on lateral PNP devices hold the potential of operating at higher frequencies than log-domain filters designed using subthreshold-MOS devices.


This paper mainly studies the condition of Cs3(HSO4)2(H2PO4) was made by using extraction solution.The crystal structure was characterized through XRD and IR.The conductivity was measured through Electrochemical system.The results shows good crystal can be grown when SO42-:PO43-=0.7:0.3,its conductivity is 2.52×10-3S/cm.


The large-scale city infrastructure project generally has the characteristics of the large investment, the complex relationship, the tight time arrangement and the high- quality standard.How to carry out the organization and the coordination of a project and realize the project targets of the investment, schedule and quality, is the important lesson of the modern construction project. The purpose of this study is to summarize the experience and lesson in management of construction project of the Shanghai Wai Gao Qiao Harbor, to investigate the general regulation and method of large-scale city infrastructure project and to offer available reference for organization and management of the related construction project.


Objective. We analyzed a hygienic state of various water supply source s and its impact on the formation of stomatologic pathology in the population of Zakarpattia. Materials and methods. The following methods for water survey: epidemiological, instrumental, and laboratory, sanitary-chemical and mathematicalstatistical processing of study results were used in the study. Results: a problem of the formation of stomatologic pathology was considered, a role of the objects for water supply of the population of the Zakarpattia was determined. Conclusions: We determined the impact of natural -and anthropogenic factor on the functioning of water ecosystems, it poses an ecological hazard not only for their development, but also for the existence of the man. We demonstrated the presence of direct correlative links between the state of water supply objects and stomatologic morbidity among the locals. "Content of iron in the water" r=0,30 (p


The results presented are compatible with the hypothesis that Lewis (Le, le) and secretor (Se, se) are two independent loci which interact in the phenotype (Ceppellini, 1955a, b). The special feature of the Fulani and Habe is that the phenotype frequencies of non‐secretor and Le – are different from those which have been observed in other populations, and yet the independence of Lewis and secretor has again been demonstrated. Family studies in the Habe appear to be in good agreement with the hypothesis that Le – is recessive.


There is much uncertainty regarding the present and future state of Himalayan glaciers, which supply meltwater for river systems vital to more than 1.4 billion people living throughout Asia. Previous assessments of regional glacier mass balance in the Himalayas using various remote sensing and field-based methods give inconsistent results. In this study, declassified Hexagon stereo imagery is processed to generate a digital elevation model (DEM) in the Bhutan Himalayas. Results indicate that the Hexagon imagery database represents a largely untapped resource for understanding decadal scale patterns of mass balance in the region. Future research will utilize the imagery and DEMs to quantify changes in volume and extent of glaciers in the Bhutan Himalayas by comparing the historical imagery to more recent data and calculating changes in ice volume over an approximately 40 year period.


The feasibility of conversion of soy molasses, a low value by-product of soy protein production, to lactic acid by fermentation with Lactobacillus salivarius was investigated. The basic environmental parameters affecting growth and lactic acid production were determined. Lactic acid production in soy molasses was optimal at pW 5.6 and 42 o C. Addition of 0.5% yeast extract to soy molasses reduced fermentation time from 36 to 10 hr and increased lactic acid production by 30%


How to select and optimize the evaluation indicators from many characteristic information to characterize the internal insulation condition of GIS equipment, and establish a scientific technical and economic evaluation model of insulation condition is a huge challenge needs to be addressed urgently. Motived by this purpose, this study simulates the deterioration process of four typical insulation defects in GIS to obtain the information of UHF, ultrasound, and SF6 decomposition components excited by different degradation stages of each insulating defect simultaneously. Moreover, the operating environment conditions, running time, overhaul times, and the residual value of equipment are taken into account. Using the improved minimum-redundancy-maximum-relevance (mRMR) criterion and genetic algorithm, a comprehensive evaluation index system including the 23 evaluation indicators in three categories is established, which covers the PD hazard, SF6 insulation performance, equipment running time and environment, and residual value. The research lays a foundation for the later construction and application of multi-source information fusion evaluation model of GIS equipment insulation condition considering economic value.


This study examines the effects of robot-based learning on learners' creativity. When compiling all previous creativity analyses, robot-based classes were found to increase creativity in an effective way, and all the sub-elements of creativity (fluency, originality, openness, and susceptibility) scored significantly higher in post-verification than pre-verification. Furthermore, while there were no clear differences between gender, tests for creativity according to grade level demonstrated a clear increase in the results of higher grades (5th and 6th grade). From these results, the following conclusions could be drawn. First, in elementary school, robot-based classes increased learners' creativity effectively, regardless of gender. Second, in order for robot-based classes to contribute to increasing students' creativity, a systematic class strategy to effectively utilize the robot medium according to students' level is required.


Automatic cloud detection and classification utilizing satellite cloud imagery have different meteorological applications, for instance, weather forecasting and climate monitoring. Satellite perception is vulnerable to noises, as conventional cloud classification strategies are sensitive to noises and exceptions; it is durable for traditional cloud classification techniques to accomplish solid outcomes. To manage these issues, a satellite cloud classification strategy utilizing Optimal Radial Basis Neural Network (ORB-NN) based machine learning classifier is utilized. This proposed technique includes three primary stages preprocessing, feature extraction (wavelet and texture) and classifier.Here RB kernel optimization process optimizes inspired optimization model i.e. Geneticbased Harmony Search (GHSO) optimization are used to enhance classification performance of cloud images. In the testing process,the input cloud imagesare classifiedas low level, medium level and High level with most extreme accuracy contrasted with existing papers. The performance of the outlined ORB-NN classifier is assessed and which gives the general accuracy of 97.37 % with 95.66% for Low-Level Clouds, 98.77% for Middle-level Clouds and 93.33% for High-Level Clouds compared to different classifiers.


This paper investigates the potential advantages of packet-based transport by providing a quantitative economic comparison between a model packet transport network (PTN) and a model circuit switched transport network (CTN). The paper addresses three economic metrics, CapEx, transport capacity efficiency, and OpEx. Quantitative measures are developed for the first two metrics. OpEx is considered on a more general basis, however a relevant publicly available metro Ethernet forum (MEF) quantitative study is summarized. The results of the economic comparison validate the theoretical advantages of packet-based transport for two different customer service demand scenarios: 1) all data 2) 25 % TDM and 75% data. For the all data demand scenario the PTN provides a 48% CapEx equipment cost advantage over the CTN. The PTN requires 70% less transport bandwidth than the CTN to transport the same set of service demands. This transport capacity efficiency advantage can be leveraged to route additional customer demands. For the 25 % TDM / 75 % data demand scenario, the CapEx cost advantage of the PTN over the CTN is reduced to 25 %, and the transport capacity gain is reduced to 57%.


PURPOSE: A system for resourcing waste generated gas based on a hydrate technology is provided to increase the recycling efficiency of energy and reduce the generation of greenhouse gas by recycling waste gas generated from anaerobic digestion facilities or landfills of small and medium sizes. CONSTITUTION: A methane gas mixture is extracted from waste generated gas(S100). Impurities contained in the methane gas mixture is eliminated in a pre-treating process(S200). The pre-treated methane gas mixture is concentrated(S300). The concentrated methane gas mixture is hydrated, and impurities are eliminated from the mixture in order to form and refine methane gas hydrate slurry(S400). The refined methane gas hydrate slurry is shaped, and the intensity of the shaped slurry is maintained(S500). A ice film is formed on the outer surface of the shaped methane gas hydrate to maximize the self preserving effect of the hydrate(S600). The ice film formed methane gas hydrate is stored at low temperatures(S700).


Taking the Mekong River basin as the study area,this paper analyzed and estimated the changes of agricultural drought on a monthly scale in terms of the typical index of soil water content in the root layer.The regional climate model(RegCM3) under the A1B scenario is used in the simulation of soil water content and other surface variables.Based on the theory of surface energy balance,it systematically analyzed the relationship and variation between the main factors of agricultural drought(such as precipitation,evaporation,surface temperature and soil water content of root layer) and atmosphere circulation,surface energy fluxes(such as sensible flux,latent heat flux,surface net flux) simulated by RegCM3.Through land surface water and energy fluxes balance,this paper identified preliminarily the occurrence mechanism of agriculture drought in the Mekong River basin.The estimation indicated that the surface temperature would increase obviously,but the soil moisture could decrease remarkably in late spring(June) and autumn(October).During the latter two periods,the study area is likely to experience a reduction in precipitation and an intensification of evapotranspiration,which could lead to the occurrence of agricultural drought in the study area especially in the non-irrigated agricultural regions.


This study examines whether the analysts' opinions or their conclusions are distinctive and indicative to the market, based on the published articles written by the analysts on the annual reports of the listed companies. The opinions are qualitative judgment of the analysts. The evidence indicates that the analysts have certain capability in the security analysis. But no strong evidence are found to support that they have quite specific ideas. The analysts would do their good or bad judgment with different information concerned and different methods used, and they would tend to use the methods more flexible and the information more explicit when they do the bad judgment. No apparent differences in information concerned and methods used in the analysis for the different industries, and failed/normal firms are found. The opinions of the analysts are quite dependent on the auditors' opinions and the present performance of the analyzed firms. However, the study indicates that the qualitative judgment of the analysts is valuable for prediction on the future performance of the listed companies.


The article provides an analysis of scientific and technical publications (articles and patents) on the components of multifunctional additives for gasoline, their chemistry and development companies. According to the detergent component, for the first time, based on the analysis of these documents, an integral assessment of the effectiveness of active substances on various elements of the fuel system is given. The article summarizes the current requirements for the content of detergent additives in gasoline of the leading manufacturers, provides standards and currently used methods for evaluating the effectiveness of detergent components. The issues of the market of multifunctional additives are considered by summarizing the marketing statements of the leading Russian and world oil companies, which allows us to draw conclusions about the principal component composition of additives used in commercial branded gasoline. The cost and quantitative assessment of the market of multifunctional additives and branded gasoline is given. The relevance of the topic and this review is high because it given the almost complete absence of gasoline with domestic multifunctional additives on the Russian market. The review will be useful both for specialists involved in the development and testing of multifunctional additives and branded gasoline, and for employees of oil companies (regional sales departments) responsible for promoting new branded fuels to the market.


An apparatus and method for treating BFG and LDG by-product gas generated during blast furnace operation or converter operation are provided. The blast furnace and converter by-product gas treatment device as an example of the configuration, the first line provided for the holder processing of the BFG between the blast furnace and the BFG holder; and the second provided for the treatment of the LDG holder between the converter and the LDG holder line; And a first connection line provided between the blast furnace and the LDG holder for LDG holder processing of the BFG and a second connection line provided for the BFG holder processing of the LDG between the BFG holder and the second line. It can be configured to include; BFG and LDG holder combined line. According to the present invention, it is possible to prevent gas processing delays or processing interruptions in advance, and in particular, to enable recovery of previously inevitably treated defense gases, and ultimately, renewable energy through by-product gas (waste gas). It is to provide an improved effect to enable the acquisition.


In practice, IOT (Internet of things) gateways are often used between sensor networks and the Internet to provide advanced services such as device monitoring and control. Sensor networks are connected to the Internet via these gateways based on various transmission protocols. In particular, the main features of IOT gateways are reliability, high real-time, security and so on. This paper proposes a heterogeneous IOT gateway based on dynamic priority scheduling algorithm. This gateway realizes data conversion and transformation between the Internet and sensor networks as well as several kinds of communication protocol: RS485, Bluetooth, CAN, Zigbee and GSM. To ensure the data security and reliability for IOT gateway, some higher-level protocols are designed and implemented on the gateway. A dynamic priority scheduling algorithm of a real-time system is also used in the gateway to address the problem of data concurrency and improve real-time performance by efficiently scheduling tasks. Simulation results reveal that the gateway realizes the data transmission between sensor networks and the Internet using specific higher-level protocols and response within a very short delay, achieving the goal of addressing the problem of data concurrency.


Much of the research on buildings and the environment is of a technical-economic nature. But so far, this has not led to any great changes in practice. This article brings organising into the research agenda: Does organising matter for the environmental performance of buildings? If so, how? This question is investigated by a comparative analysis based on an empirical approach. Two housing management practices and their buildings' energy and water performances are analysed relative to each other. It is possible to trace energy and water consumption levels to characteristic management styles (e.g., metaphors of 'caring' and 'emergency-driven'). The analysis shows that organising concepts, more specifically, characteristic management styles, matter for the environment. Copyright © 2009 Inderscience Enterprises Ltd.


We have observed multiple optical Bloch waves in a semiconductor photonic lattice. This photonic lattice comprises epitaxial quarter‐wave periodic layers surrounding a periodic quantum‐well region. After growth, the layers are structured laterally into periodic square unit cells by reactive‐ion‐beam etching. When photoexcited, the lattice emits a complex angular distribution of photons that reflects its periodic structure. Scattered light is distributed according to the Laue conditions in analogy with x‐ray diffraction from a bulk crystal. Optical Bloch waves photostimulated in the lattice are analogous to electron Bloch waves in an atomic lattice. These optical Bloch waves exhibit long‐range translational symmetry and local symmetry due to the shape of the unit cell. Interestingly, the far‐field pattern of stimulated emission gives a direct mapping of the allowed Bloch wave vectors in the Brillouin zone. The mapping exhibits a wave‐vector gap at the Bragg condition and may be associated with a photonic e...


Objectives: To explore the effect of peer-support scene health education on self-management among elderly patients with diabetes. Methods: Totally 120 elderly patients with diabetes were randomly divided into the control group and the study group with 60 patients in each group, Both groups received the peer-support education provided by the hospital. The control group received peer support oral presentation health education, while the study group received peer support scene interactive health education. We compared the education effect between the two groups after completing six modules of health education. Results: The skill mastery in study group were better than those in control group, including the self-injection skill by insulin pen, blood glucose self-test skill, recognition and treatment of hypoglycemia, and diabetic food exchange method(P0.05).The diabetes general knowledge mastery between the two groups has no statistically significant. The satisfaction of teaching methods and contents in study group was higher than that in control group(P0.005). Conclusions: Peer-support scene health education have iconicity, participation and interest for elderly patients with diabetes which could increase their initiatives to take part in the health education and improve their self-management skills.


This article shows a lower cost realization of a compute cluster using Debian distribution such as PelicanHPC. We will explain parameterization and network configuration for master and compute slave nodes. Performance testing will take place using flops.f file given by MPI. The results will be compared between differents clusters. We will explain quickly how the temperature is controlled by a microcontroller unit.


The influence of evaporation temperatures on the electronic structures of molybdenum oxide (MoOx) films and the electrical properties of organic light emitting diodes were investigated. MoOx films evaporated at a high temperature and a high deposition rate are close to a stoichiometric phase, but become less effective when they are used as a hole injection layer. However, when MoOx is evaporated at a lower temperature and a slower rate, there are large amounts of defect-related states present in the forbidden gap, which make the films behave like a high work function conductor and an effective hole injection layer.


Background:
 Hypertensive disorders of pregnancy (HDPs) are a group of conditions that contribute to maternal morbidity and mortality, disproportionately affecting minority and low-income individuals. Complications from these HDPs may result in poor outcomes for mother and child during pregnancy or post-pregnancy. Disparities in HDPs may be associated with concentrated racial and income inequality in an individual's activity space, such that the social exposure of places is not only formed by residence but also by daily mobility of the population at large. A novel aspect of women's residential neighborhood environment can be explored by measuring daytime population mixing. Mobile phone data can be used to estimate social mixing during the daytime for income and racial/ethnic groups by describing the undercurrents of population mobility in neighborhoods.

 Objective:
 To estimate the association of daytime racial and income segregation with HDPs among women who gave birth from 2018 to 2019 in metro Atlanta.

 Methods:
 Data for women who gave birth in Metro Atlanta in 2018 and 2019 were abstracted from vital statistics records to determine HDP diagnosis and maternal residence by census tract. HDPs were grouped into pre-pregnancy hypertension, gestational hypertension, and eclampsia. Mobile phone location data from CUEBIQ were used to estimate median household income density in each census tract and racial/ethnic density, as a function of where devices moved between the hours of 7am and 10pm. Racial and economic composition of the device was assigned by the user's estimated home census tract. The Index of Concentration at Extremes (ICE) was calculated as the mixing of mobile devices in each census tract, by race and income. Tracts were categorized as concentrated disadvantage for an ICE score less than -0.3 and concentrated privileged for an ICE score greater than 0.3. Logistic regression models were used to estimate odds of HDPs in census tracts with micro-segregation and income inequality during the daytime, compared to not at extremes.

 Results:
 There were 122,482 births included in the maternal cohort, and 8.1% of births occurred among women with a diagnosed HDP. Black women had a higher rate of HDPs compared to White women (9.7% versus 6.9%). Census tracts with higher daytime micro-segregation were associated with higher odds of HDPs compared to tracts not in the extremes (OR = 1.42; 95% CI= 1.35, 1.49). Census tracts with higher daytime income inequality were also associated with higher odds of HDPs (1.26;1.20, 1.33).

 Conclusions:
 The odds of maternal HDPs were higher among women in census tracts with greater racial daytime segregation and more income disparity, compared to tracts that were not identified as extremes. Describing and distinguishing social epidemiologic patterns for HDPs by population mobility may provide a better understanding of the social context of who is most at risk.


Based on the achievements concerning the formation of granitoids in the East Kunlun orogenic belt, Qinling orogenic belt, Xingmeng orogenic belt, Altay orogenic belt, Yanshan orogenic belt and South China peraluminous granitoids, this paper has dealt with the formation of key orogenic zone granitoids in mainland China and the continental crust growth and reached some preliminary conclusions: the input of the asthenosphere (mantle convection)thermal materials to the mainland made up the foundation of the growth and reworking of the earth's crust. The formation, evolution and reworking of the continental crust mainly underwent magmatism, whose formation, migration and positioning made up the basic process of continental crust growth. Mantle-derived basaltic magma underplating on the bottom of the continental crust and intraplating within the crust constituted the basic form of the input of the asthenosphere to the mainland. Delamination of mafic orogenic belt in the lower crust was the key mechanism, which made the continental crust composition chemically intermediate (andesite and diorite, or trachyte andesite and monzonitic rock). The contraction extrusion tectonism thickened the continental crust to ≥50 km, which was the necessary prerequisite for inducing delamination of the mafic lower crust. The igneous tectonic assemblage and its time series seem to be the key to identifying the separation of the continental crust from the mantle asthenosphere until the eventual formation


Two new alkaloids, evellerine (V) and 7-O-demethylevolitrine (IIb), together with the known furoquinoline alkaloid skimmianine, have been isolated from Evodia elleryana F. Muell. (family Rutaoeae).


The axial piston pump is a key component of the industrial hydraulic system, and the failure of pump can result in costly downtime. Efficient fault detection is very important for improving reliability and performance of axial piston pumps. Most existing diagnosis methods only use one kind of the discharge pressure, vibration, or acoustic signal. However, the hydraulic pump is a typical mechanism–hydraulics coupling system, all of the pressure, vibration, and acoustic signals contain useful information. Therefore, a novel multi-sensor fault detection strategy is developed to realize more effective diagnosis of axial piston pump. The presence of periodical impulses in these signals usually indicates the occurrence of faults in pump. Unfortunately, in the working condition, detecting the faults is a difficult job because they are rather weak and often interfered by heavy noise. Therefore, noise suppression is one of the most important procedures to detect the faults. In this article, a new denoising method based on the Walsh transform is proposed, and the innovation is that we use the median absolute deviation to estimate the noise threshold adaptively. Numerical simulations and experimental multi-sensor data collected from normal and faulty pumps are used to illustrate the feasibility of the proposed approach.


Various methods for the preparation of unsaturated 2-diphenyl-methyl-piperidines have been studied. The position of the double bond in the piperidine ring has been the object of special investigation.


The empirical mode decomposition (EMD) method is used to process the observed wave data, constant values are added respectively at the balanced positions of both data ends to restrain the end effects, and the wave data are then decomposed into ten intrinsic mode functions (IMFs) and a residual trend term. Hilbert transform is made for each of ten IMFs to obtain Hilbert spectrum of wave. It is shown from the analysis results that the distributing trend of IMFs in Hilbert spectrum is consistent with the varying trend of spectral lines in Fourier spectrum, and the central frequency of the first IMF corresponds to the spectral peak frequency of Fourier spectrum. Therefore, it is suggested that the EMD method is a good method for demeaning the nonlinear and nonstationary process data, and the demeaning process and the data detrending are unified.


The editors are publishing this note to alert readers to concerns about [this article][1] ([1][2]). In Figs. 5, 6, and 7, tissue images were used to provide evidence for the presence of tumors. Examination by the editors and original reviewers determined that the images are either of insufficient


The cancellation of the October 26 meeting of the European Union's council of finance ministers, or Ecofin, has further eroded confidence in its ability to solve the burgeoning sovereign debt crisis in the eurozone. A viable strategy is needed now—and as Stuart Holland illustrates, two viable strategies are even better than one.


: Understanding the natural history and ecology of endangered species is critical for developing effective, evidence-based conservation and management plans. The mottled dusky-wing Erynnis martialis is a skipper butterfly inhabiting oak savanna, oak woodlands, alvars, and tallgrass prairie habitats containing their host plants, Ceanothus spp. Listed as endangered in Canada, few populations persist in Ontario and Manitoba, but there are no formal estimates of population size or what influences spatial variation in adult density, and we have limited knowledge of phenology. To address these knowledge gaps, we conducted spatially explicit mark−re-sighting over multiple years at 2 of the largest known populations in Ontario (specific locations withheld). Population sizes at Site A were estimated to be 1159 individuals (confidence limit [CL] = 845−1598) in 2021 and at Site B, 626 individuals (CL = 466−851) in 2020 and 2227 individuals (CL = 1110−4463) in 2021. Most (81%) re-sightings occurred within 5 d of marking, suggesting that adults likely live less than 1 wk. High densities of adults were generally associated with high Ceanothus spp. abundance and open canopy, but relationships varied by site and year. Peak flight across sites and years ranged from 5−13 June. We recommend that existing and prospective habitat managers prevent succession with brush-cutting and/or prescribed burns, specifically in areas of abundant Cean-othus spp. This work provides valuable information for future management and recovery efforts, including planned translocations to both historically occupied and newly restored sites.


Recent studies have demonstrated that the combination of x-ray tomography during triaxial tests ("in-situ" tests) and 3Dvolumetric Digital Image Correlation (3D-DIC) can provide important insight into the mechanical behaviour and deformation processes of granular materials such as sand. The application of these tools to investigate the mechanisms of failure in rocks is also of obvious interest. However, the relevant applied confining pressures for triaxial testing on rocks are higher than those on sands and therefore stronger pressure containment vessels, i.e., made of thick metal walls, are required. This makes in-situ x-ray imaging of rock deformation during triaxial tests a challenge. One possible solution to overcome this problem is to use neutrons, which should better penetrate the metal-walls of the pressure vessels. In this perspective, this work assesses the capability of neutron tomography with 3D-DIC to measure deformation fields in rock samples. Results from preand post-deformation neutron tomography of a Bentheim sandstone sample deformed ex-situ at 40 MPa show that clear images of the internal structure can be achieved and utilised for 3D-DIC analysis to reveal the details of the 3D strain field. From these results the character of the localised deformation in the study sample can thus be described. Furthermore, comparison with analyses based on equivalent x-ray tomography imaging of the same sample confirms the effectiveness of the method in relation to the more established x-ray based approach. c © 2015 The Authors. Published by Elsevier B.V. Selection and peer-review under responsibility of Paul Scherrer Institut.


KNOCA is a European network that aims to provide resources and inspire those who commission, design, advocate and scrutinise climate assemblies to ensure the highest standards of practice. The network hosts events and produces a range of practical resources, alongside other knowledge development activities. We welcome individuals and organisations with experience or interest in either commissioning, running or analysing these processes and their outputs in Europe. Please reach out to us at email@example.com to share, discuss and inform best practice and new developments in climate assembly design, delivery and analysis.


2-(9-Anthryl)-2-hydroxy acetic acid enantiomers were for the first time separated by capillary electrophoresis using hydroxypropyl-β-cyclodextrin as chiral selector. The effects of the type and the concentration of β-eyclodextrins, the background electrolyte and its pH on resolution were investigated. A good separation of 2-(9-Anthryl)-2-hydroxyacetic acid was achieved by using 20 mmol/L Tris-H3PO4 (pH 6.0) containing 15 mmol/L hydroxypropyl-β-cyclodextrin. The baseline separation of 2-(9-anthiyl)-2-hydroxyacetic acid enantiomers was achieved with a resolution factor of 1.58.


In 1905 we published a short paper,' qualitative in character, with the purpose of demonstrating from simple laboratory measurements the existence of a linear force, apart from the volume expansion, exerted by growing crystals. We sought to show (i) that when a crystal, fed with appropriate saturated solution, grows in an open crack between walls with which it comes into contact on both sides, pressure is exerted to separate the walls, notwithstanding unrestricted opportunity for growth in other directions; (2) that the linear force thus exerted is of the order of magnitude of the breaking strength of the crystal and therefore a geologic force of considerable magnitude and importance. The crucial experiment offered in support of this conclusion was prepared in an ordinary crystallizing dish upon the bottom of which was cemented a block of plate glass having a plane upper surface. A well-formed crystal of alum was laid upon this plane surface, and upon it a second plane glass plate carrying a weight. A saturated solution of alum was poured into the crystallizing dish in sufficient quantity to cover the crystal, and then left to evaporate quietly under conditions reasonably free from temperature change and from


pages to do it. Obviously, Rogerson is able to present the reader with considerably more wealth of detail when he s u m m a r i z e s t he ma jo r works of nineteenth-century biblical scholars than can Kraus. Rogerson deals with two questions: "How did the critical method arise in Germany in the 19th century, and how was it reception into England affected by the theological and philosophical climate prevalent in 19th century England" (p. ix). Appropriately, Part One is entit led "Germany 1800-60"; Part Two: "England 1800-80"; and Part Three: "England from 1880 and Germany from 1860: The Streams Converge." The nineteenth-century scholar who "achieved the breakthrough which entailed that Old Testament studies could never again be the same" (p. 272) was Wilhelm Martin Leberecht de Wette (1780-1849). That de Wette is the hero of the book is obvious from the fact that his is the only photograph appearing in the book. De Wette's two-volume Beitrage zur Einleitung in das Alte Testament (Halle, 1806-1807) was his most significant contribution toward inaugurating a new era in critical Old Testament research. In those two volumes de Wette offers the first work of Old Tes tament scholarship "to use the critical method in order to present a view of the history that is radically at variance with the view implied in the Old Testament itself (p. 29). Rogerson then traces a line from de Wette to Wel lhausen , specifically to Wellhausen's 1878 publication of his History of Israel, better known by its 1883 title: Prolegomena to the History of Israel. After carefully retracing the steps of all those German Protestant scholars who followed de Wette and offering well-documented statements, Rogerson presents de Wette's own adherents (though de Wette founded no school); Wilhelm Gesenius (1786-1842), who wrote the still unsurpassed Hebrew Grammar; Carl Peter Wilhelm Gramberg (1797-1830), the author of a twelve-hundred page Critical History who is not even mentioned by Kraus; and Johann Friedrich Ludwig George (1811-1873), whose book The Older Jewish Festivals (1835) is so insightful that Rogerson asks, "Why did it take over 49 years for the step from George to Wellhausen to be taken?" (p. 68). For the answer to that question (and others you may not have thought of asking) buy the book, both for its erudition and for its juicy quotations. One Englishman, for example, dissenting from the critical method, described Eichhorn, the founder of Old Testament In t roduct ion as "a man of splendid talents and prodigious acquirements, but awfully imbued with infidelity" (p. 165). Or how about the Englishman who faulted Michaelis's Commentaries on the Laws of Moses because they were not "free from the licentiousness of conjecture" (p. 184).


A sensitivity matrix is defined as a measure of trajectory deviations to small parameter variations of both open and closed loop controlled nonlinear parabolic and first-order hyperbolic systems. In general the parameters may enter through the system equations or the boundary conditions and may be time or spatially dependent. The introduction of a positive measure of the sensitivity, the norm of the sensitivity matrix, into the performance index is shown to be effective in limiting the trajectory deviations due to the parameter variations. The open and closed loop control of a double pipe heat exchanger is analyzed with the open loop problem solved by an approximate procedure. The sensitivity reformulation is successful in reducing trajectory sensitivity, however at the cost of decreased overall performance.


Timor is the largest of the Lesser Sunda Islands, which comprise the south-eastern part of the Indonesian Archipelago (Audley-Charles 1968). It is a non-volcanic island situated in the Outer Banda Arc which lies between the Sahul Shelf of Australia and the Sunda Shelf of South-east Asia (White et al. 2006). Timor-Leste (East Timor) occupies the eastern half of the island of Timor, encompassing an area of 14 875 km2 (White et al. 2006). This note focuses on the easternmost part of Timor-Leste, east of the town of Lospalos, including the newly created Nino Konis Santana National Park, Timor-Leste's first national park. For a description of the climate, geology and geomorphology of the area, see White et al. (2006).


We have previously described two types of immunoregulatory interactions between T cell subsets; in one an Ly‐1; I‐J+ inducer cell makes a soluble product (Ly‐1 T suppressor inducer factor, TsiF) that is also I‐J+ and which activates the effector cells of a suppressor circuit. Under normal circumstances the Ly‐1 TsiF activity is restricted by Igh‐V‐linked genetic polymorphisms. However, we now find the genotype of the inducer cell does not control this restriction. The inducer cell acquires a new Igh‐V‐linked self repertoire if it ("adaptively") differentiates in an appropriate F1 radiation chimera or in an F1 thymus graft in a homozygous nude mouse. Conversely, cells from F1 mice cannot acquire this "dual" self repertoire if the host in which they differentiate does not express the relevant selecting structure(s).


The proposed Temporal Experiment for Storms and Tropical Systems (TEMPEST) satellite mission addresses key science needs related to cloud and precipitation processes using a constellation of five CubeSats with identical five-frequency millimeter-wave radiometers spaced 5-10 minutes apart in orbit. This CubeSat constellation will directly observe the time evolution of clouds to study the conditions that control the transition of clouds to precipitation. The TEMPEST millimeter-wave radiometers will penetrate into the cloud to directly observe changes as the cloud begins to precipitate or ice accumulates inside the storm. TEMPEST provides observations at five millimeter-wave frequencies from 90 to 183 GHz using a single compact instrument that is well suited for a 6U CubeSat architecture and fits well within the NASA CubeSat Launch Initiative capabilities.


Almost half of the care homes inspected by the Care Commission in Scotland failed to meet national standards on food and nutrition.


An acquisition of pseudo-noise(PN) sequences using double adaptive threshold decision was presented for DSSS system in this paper. And, its performance based on double dwell acquisition was analyzed. It has better performance than CFAR and can be used in various mobile communications environment, which has been proved by theoretical analysis and computer simulations.


The purpose of this thesis was to study the view of six teachers, working in three different field areas, on ethics questions and ethics teaching in schools, from a global perspective. My second ai ...


Yellow fever (YF) is a mosquito-borne flaviviral hemorrhagic fever (VHF) that causes severe hepatitis, renal failure, bleeding, and quick terminal events such as shock and multi-organ failure. There are currently no particular anti-viral medications for the management of the YF virus (YFV). Despite the availability of a commercial YFV vaccination, there are roughly 30,000 fatalities globally each year, with instances rising over the previous 20 years. After being translocated into the endoplasmic reticulum lumen, glycosylated NS1 resides as a membrane-associated dimer, where it is required for viral genome replication. The secreted hexamer NS1 has a role in immune evasion and pathogenesis and has been discovered as a possible diagnostic marker for the early identification of viral infections.

The main aim of this study is to analyze the small molecule as a potent drug candidate against the target NS1 protein.

In this study, Computational approaches, including High throughput virtual screening, Molecular docking, and dynamics simulation, were carried out against the target NS1 protein using three different chemical libraries Enamine, Asinex, and NCI. The selected lead compounds were validated through HOMO-LUMO analysis, ADME prediction, and Toxicity parameters to analyze the biological and pharmacological properties of the lead small molecules.

In this study, computational approaches, including high throughput virtual screening, molecular docking, and dynamics simulation, were carried out against the target NS1 protein by using three different chemical libraries: Enamine, Asinex, and NCI. The selected lead compounds were validated through HOMO-LUMO analysis, ADME prediction, and Toxicity parameters to analyze the biological and pharmacological properties of the lead small molecules.

From the result, it was concluded that the leads possessed the highest docking scores, interacting with the binding residues, and were stable in the simulation period.

From the results, it was concluded that the leads possessed the highest docking scores, interacted with the binding residues, and were stable in the simulation period.

Overall findings revealed that the lead three small molecules could act as the potential drug candidate for the target NS1 protein to inhibit the diseasing efficacy of Yellow fever.

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We consider two inverse problems for the multi-channel two-dimensional Schr\"odinger equation at fixed positive energy, i.e. the equation $-\Delta \psi + V(x)\psi = E \psi$ at fixed positive $E$, where $V$ is a matrix-valued potential. The first is the Gel'fand inverse problem on a bounded domain $D$ at fixed energy and the second is the inverse fixed-energy scattering problem on the whole plane $\R^2$. We present in this paper two algorithms which give efficient approximate solutions to these problems: in particular, in both cases we show that the potential $V$ is reconstructed with Lipschitz stability by these algorithms up to $O(E^{-(m-2)/2})$ in the uniform norm as $E \to +\infty$, under the assumptions that $V$ is $m$-times differentiable in $L^1$, for $m \geq 3$, and has sufficient boundary decay.


Gaucher Disease (GD) is an autosomal recessive metabolic disorder due to glucocerebrosidase deficit. There are three main clinical phenotypes: type I (GD1: non-neuronopathic form), characterized by a visceral involvement that can mimic a hematologic disease; type II (GD2: acute neuropathic form) and type III (GD3) characterized by a slower and progressive neurological involvement. Hematologists have often involved in diagnosis and management of the GD1 patients. Increasing data and our experience show that patients with GD1 may present manifestations of Parkinson's disease or Parkinsonism symptoms (tremor, bradykinesia and rigidity), frequently combined with cognitive impairment and behavioral alterations.
 The aim of this study is to deeply investigate the neurological and neuropsychiatric aspects in GD1 patients in order to identify clinical and subclinical neurological manifestations, including cognitive impairment and behavioral alterations in this category of patients.
 This observational, monocentric, and prospective study is planned to enroll 22 GD patients (19 GD1 patients and 3 GD3 patients with or without active neurological signs) aged >12 years. Neurological assessments include: clinical evaluation including Severity Scoring Tool Unified Parkinson's Disease Rating scale and Epworth Sleepiness scale, psycho-diagnostic tests and psychiatric evaluation using cognitive test battery and two psychiatric (BPRS) and psychological (CBA 2.0) questionnaires, Somatosensory and Motors Evoked Potentials, Electroencephalography (EEG) and magnetic resonance (MR) 3Tesla, at baseline, after 12 months and 24 months. Preliminary results concerning the baseline evaluation of first cohort of patients are here reported.
 Since June 2019, 11 patients (10 GD1 and 1 symptomatic GD3) have been enrolled. Neurological impairment according to the major features (Gaucher severity score tool) was found in 4/11 patients: signs of Parkinson disease in 1 GD1 patient, motoneuron disease in 1 GD3 patients, abnormalities in ocular motility and psycho-cognitive disturbances in 2 GD1 patients. Minor features of a neurological impairment was found as follows: bradykinesia in 5 GD1 patients, excessive daytime sleepiness in 5 GD1 patients, and saccadic slowness in 1 GD1 patient. EEG revealed focal or diffuse slow waves in 6 patien patients (5 GD1 and 1 GD3). Cognitive and psychological evaluations revealed the presence of significant psychiatric symptoms such as depression, anxiety, and physical concerns. Six patients (5 GD1and 1 GD3) surprisingly had sensorineural hearing loss. Auditory Brainstem Response revealed abnormal disyncrony-like morphology and central speech processing in noise in 3 GD1 and in 4 (3 GD1 and 1 GD3) patients, respectively. Ophthalmological evaluation highlighted a normal visus and intraocular pressure in all patients. Moderate alterations of the fundus were present in 2 patients (1 GD1 and 1 GD3) and superficial corneal dystrophies in 3 (2 GD1 and 1 GD3) patients. An increased latency and moderate reduction in the amplitudes of optic nerve function were found in all tested patients. The retinal responses to the Electroretinogram exam were of excellent quality in all but one GD1 patient, who showed slightly reduced responses. The spectral domain-optical coherence tomography (SD-OCT) examination showed posterior pole alterations in 3 patients (2 GD1 and 1 GD3) and borderline nerve fiber layers of the optic nerve (RNFL) in 3 (2 GD1 and 1 GD3) cases.
 Our clinical study represents quite an innovative one, since neurological investigations are focused on GD2 and GD3 phenotypes. Neurological involvement with different phenotypical aspects were also found in GD1 patients. Sensorineural hearing loss and central alteration of auditory processing were present in higher incidence compared to the unaffected population. Psychological data din't show significant cognitive impairments, but pointed out some psychiatric aspects, such as anxiety, depression and somatic concerns.
 MR 3Tesla can be an important tool to better understand these data. Evaluation of the remaining cohort of patients and longer follow-up could confirm that neurological involvement is not exclusive of the type 3 GD.

 No relevant conflicts of interest to declare.


Purpose
The light detection and ranging sensor has been widely deployed in the area of simultaneous localization and mapping (SLAM) for its remarkable accuracy, but obvious drift phenomenon and large accumulated error are inevitable when using SLAM. The purpose of this study is to alleviate the accumulated error and drift phenomenon in the process of mapping.

Design/methodology/approach
A novel light detection and ranging SLAM system is introduced based on Normal Distributions Transform and dynamic Scan Context with switch. The pose-graph optimization is used as back-end optimization module. The loop closure detection is only operated in the scenario, while the path satisfies conditions of loop-closed.

Findings
The proposed algorithm exhibits competitiveness compared with current approaches in terms of the accumulated error and drift distance. Further, supplementary to the place recognition process that is usually performed for loop detection, the authors introduce a novel dynamic constraint that takes into account the change in the direction of the robot throughout the total path trajectory between corresponding frames, which contributes to avoiding potential misidentifications and improving the efficiency.

Originality/value
The proposed system is based on Normal Distributions Transform and dynamic Scan Context with switch. The pose-graph optimization is used as back-end optimization module. The loop closure detection is only operated in the scenario, while the path satisfies condition of loop-closed.


In this article, the current state of multicultural vocational research on family of origin issues are evaluated and assessed based on Whiston and Keller's review. Previous calls to researchers are highlighted and suggestions are provided for future vocational researchers engaging in multicultural studies.


Think tank is bridging gap among academic and policy making communities, states and civil society to serve in the public interest as independent voices that translate applied and basic research into a language, form that is understandable, reliable, and accessible for policy makers and the public. Hence, Nepal is officially far from it. Although, practices in Nepal is very limited as well as narrow ideas, thinking, and approaches to sake prosperities of divergent Nepali societies and cultures. Government investment is very poor in these works. However, newly opened universities, private institutions and NGOs are work like as hybrid, are engaged in educational research activities. Over the last 10-15 years, governments, and civil society have come to rely on it, and this trend will continue to input better future of Nepal. DOI: http://dx.doi.org/10.3126/av.v4i0.12351 Academic Voices Vol.4 2014: 17-20


The author of the article for the first time refers to a little-known period in the biography of the writer-humorist A.T. Averchenko, who visited the Don in 1918-1919th. Cooperating with the local newspaper "Priazov Region", Averchenko created a multi-genre "Rostov text", which now numbers 26 publications and served as the material for the study. The biographical context allows to recreate publications in the magazines "New Satyricon", "Theatrical Courier", "The Don Wave", the writer's archive, memoirs of his contemporaries, etc. The relevance of the topic of the article is due to both the need for a scientific study of the biography of the emigrant writer and the tasks of literary local history, in particular, the possible perpetuation of Averchenko´s name in Rostov-on-Don (for example, with the memorial plaque on the building of the former editorial office of "Priazov Region"). Having indicated the characteristic feature of Averchenko's creative path – touring activities – the author of the article sets the dates of his concerts in Rostov-on-Don in 1912, 1914, 1918, names the addresses (Asmolovsky theater, cafe "Empire", theater "Grotesque", etc.) and contacts in the civil and military spheres of the city. For the first time Averchenko's way from Petrograd to the south in 1918 is reconstructed in details, the reasons of his departure from the capital are in many ways illuminated in a new way, littleknown data about his wife, opera singer E.F. Petrenko are introduced into scientific circulation. The reviews of the Averchenko´s Rostov concerts of humor are analyzed. Particular attention is paid to the civic self-determination of the writer, who for the first time found himself in the epicenter of the White Movement on the Don and supported it. Averchenko's further social activities in Crimea are largely characterized as a logical continuation of the Rostov period, which together explains the reasons of his emigration.


Considered as the last great frontier of cardiac electrophysiology, atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice. The mechanisms behind this disease are not completely understood, and a precise analysis of the atrial activity (AA) signal is necessary to a better understanding. The block term decomposition (BTD) has been recently proposed as a useful tool for noninvasive AA extraction in electrocardiogram (ECG) signals. However, this tensor factorization technique was assessed only in short fixed segments of an AF ECG. To bridge this gap, the present work evaluates for the first time the temporal (intra-patient) stability of BTD by considering consecutive segments through a whole AF ECG recording. Experimental results show the consistency of BTD as an AA extraction tool, being capable of outperforming two well-known matrix-based methods and presenting a stable performance over time.