Numerical mode-match(NMM) method is an efficient technique for numerical stimulation of electrical logs.But the existing methods are complicated and puzzled because of derivation of reflection and transmission matrices.A new type of NMM,analytic radically and numeric vertically,is optimized for numerical stimulation of induction logs in inhomogeneous stratified media.It induces potential formula between the adjacent layers recurring to the continuity of electric-field intensity as well as magnetic induction density,and brings forward a transition matrix on boundary of two layers rather than previous method about reflection and transmission matrixes in analytical section.The theory has concise physical meaning and is easy for programming.In given models,the new method proved to be highly precise and effective compared with finite element method(FEM) and previous NMM method.The results agree well with those of the previous method.Furthermore,the theory about NMM is suitable for other electrical logs and is also profound to precision forward and inversion of resistivity logs.


The fall of 2022 finds the old continent in a highly problematic economic and political context. The effects of the covid pandemic have not yet been overcome, but new problems generated by an armed conflict in Europe and a harsh climate context have been added. European political leaders are stuck on topics related to saving resources and the economic survival of their own countries. The economic and social measures suggested by the political class under the pressure of the approaching winter risk generate effects on the population's health with more devastating long-term results than the covid pandemic. Reducing electricity consumption at any cost, reducing water consumption, and adjusting the thermal comfort parameters in dwellings on a large scale can affect the population's health and lead to subsequent costs that are difficult to estimate. This paper tries to analyze this context and identify a method for evaluating the effects on indoor environmental quality.


OBJECTIVES
Medication adherence is increasingly being considered as a measure for performance-based reimbursement contracts in healthcare systems. However, the association between health outcomes and adherence at the plan level is unknown.

STUDY DESIGN
Retrospective analysis of medical and pharmacy claims from a large private sector claims database from 2000 to 2009.

METHODS
We compared plan-level measures of medication adherence and health outcomes for patients with diabetes and congestive heart failure (CHF). Plan performance was based on average rates of disease complications. Medication adherence was calculated as the percent of patients having 80% of days covered for medications treating diabetes or CHF. Both adherence and outcomes were adjusted for patient differences using multivariate regression. Plans were stratified into low, moderate, and high adherence, based on adherence in the bottom quartile, middle 2 quartiles, and top quartile, respectively.

RESULTS
Average adherence varied significantly across plans. Plans with low adherence to diabetes medications had adjusted rates of uncontrolled diabetes admissions of 13.2 per 1000 patients, compared with 11.2 in moderate adherence plans and 8.3 in high adherence plans (P < .001). The adjusted rate of CHF-related hospitalization was 15.3% in low adherence plans, compared with 12.4% in moderate adherence plans and 12.2% in high adherence plans (P < .001). These patterns were consistent across different types of complications for both diabetes and CHF.

CONCLUSIONS
Private health plans vary considerably in average adherence to medications treating chronic diseases. Plans with higher average adherence had lower rates of disease complications, suggesting that medication adherence measures are potentially useful tools for improving the performance of health plans.


This article explores the textual connections between two narratives: Ibn ufayl's (581/1185–6) Risālat ayy ibn Yaqān and a brief history of religions present in two works – the General Estoria and the Stenario – produced in the Castilian court of king Alfonso X (1221–1284). Both literary narratives deal with the intersection of philosophy and metaphysics. First, Alfonso X's cultural renaissance is contextualized. Under Arabic influence, Alfonso's collaborators created a cultural synthesis that was denounced by his son Sancho in the 1290s. Second, we compare Ibn ufayl's and Alfonso X's narratives. Ibn ufayl's model was probably adapted to justify a cultural programme that blended Christianity and Pagan inheritance. Unfortunately, there is no physical evidence to prove that Alfonso's circle was familiar with Ibn ufayl's work. Nevertheless, the analysis of a common genre – following A.W. Hughes's theory – allows us to contend that Alfonso X reproduced this type of text within a Christian context.


Dear Editor Medical educators are continually in pursuit of ways to develop critical thinking, problem solving, clinical reasoning and other cognitive skills that will serve learners well as future physicians. While most educators have some understanding of pedagogy and the fundamentals of effective instruction, very few are aware of the learner's cognitive processes. Perry's Theory of Cognitive Development[1,2] is one of the most widely recognized theories for understanding adult learners' cognitive development. I challenge readers to consider how this theory might aid the instruction of medical students and residents. Perry's schema consists of nine 'positions'. These refer to one's intellectual position, or vantage point, for viewing the world. As learners navigate intellectual positions, they do so along a continuum from a passive receiver of facts to an active agent capable of complex thinking in a contextually relativistic world. Along this intellectual journey students advance positions largely in sequential order. but certain factors can advance or reverse these positions. Some theorists now view Perry's theory from four major positions: dualism, multiplicity, relativism, and commitment to relativism[2–4]: (i) Dualism; Learners hold a naïve epistemology where they believe the world consists of facts and correct answers. Authority figures (professors, doctors) offer all the answers. For dualistic thinkers, education is about accessing these authority figures and absorbing facts. Learning consists of taking, memorizing notes and regurgitating these for assessments. (ii) Multiplicity, Learners take a position where knowledge is a matter of opinion. Authority figures are perceived simply as people with opinions, all equally valid. Learners view personal feelings as the criteria through which the quality of their work should be evaluated. They feel frustrated when educators criticize their ideas or tasks. (iii) Relativism; Learners learn to evaluate information and distinguish between levels of evidence and support. They recognise that what one 'knows' is based on their perspective, assumptions, values, and other contextual factors. Educators become resources to help them learn the conventions of their discipline. (iv) Commitment to relativism; Learners recognize they must continue to use relativistic thinking to make sense of the world. This involves committing to integrating information about academic pursuits with various aspects of their personal lives.


This report analyzes the Democratic Party of Japan's (DPJ) policy platform and reviews the implications for U.S. strategic and economic interests now that the party and its coalition allies are set to take control of the Japanese government in the wake of the August 30 parliamentary elections.


Aggressive acute leukemias in children, adolescents, and adults arise due to a chromosomal translocation and subsequent fusion that occurs at chromosome 11q23 to the mixed‐linage leukemia‐1 (MLL1) gene. MLL‐rearranged leukemias comprise 10% of all human leukemias, and comparatively, have poor therapeutic outcomes compared to non‐MLL hematologic malignancies. MLL1 encodes the large, interchangeable catalytic subunit of the SET/MLL histone methyltransferase complex. Under normal physiologic conditions, it regulates a tightly controlled mechanism and specific pattern of Histone 3, Lysine 4 methylation (H3K4me). In contrast, when the SET/MLL complex is activated through fusion partners with MLL1, it causes epigenetic dysregulation promoting tumorigenic pathways such as oncogenic MYC expression. MYC dysregulation is one of the most common features across solid and hematologic malignancies. Historically, MYC has been difficult to target therapeutically due to its intrinsically disordered structure and conserved binding interfaces. Due to recent success in targeting MYC through global epigenetic modulation, we propose that targeting the DPY30 subunit of the SET/MLL complex has the potential to combat both aberrant H3K4 histone methylation patterns and downstream oncogenic MYC and MYC target gene expression. Here, we designed a high throughput screen to identify small molecules that specifically inhibit the DPY30‐ASH2L protein interaction. Through biochemical and in vitro characterization, we have validated the on‐target affinity of multiple compounds, which significantly inhibit downstream H3K4me3 and MYC expression across multiple cell lines. Additionally, we have identified a compound that abolishes MLL‐rearranged leukemic cell proliferation in vitro and significantly decreased MLL tumor burden in vivo. Through these proof‐of‐concept studies, we have identified a first‐in‐class novel therapeutic target in MLL‐rearranged leukemias through inhibition of the DPY30‐ASH2L interaction of the histone SET/MLL complex.


From the bark and wood extracts of Trichadenia zeylanica Thw., six new triterpenoids, namely trichadenic acid A (3α-hydroxyfriedelan-26-oic acid), O-acetyltrichadenic acid A, O-acetyltrichadenic acid B (3β-acetoxyfriedelan-26-oic acid), trichadonic acid (3-oxofriedelan-26-oic acid), trichadenal (3β-hydroxyfriedelan-26-al), and O-acetyl-trichadenal have been isolated, correlated, and identified. The extracts also contained friedelan-3α-yl acetate and β-sitosterol.


has as yet explicitly spoken : His power to sympathize, acquired and guaranteed by His experience of temptation. He presents Christ to view as the Sympathetic One in golden words which may be regarded as an inscription on the breastplate of the High Priest of humanity.... It is noteworthy that the doctrine of Christ's sympathy is here stated in a defensive, apologetic manner, NN'e have not a High Priest who cannot be touched,' as if there were


This research is to find out the influence of using digital storytelling and motivation on speaking skill of eleventh-grade students of SMA Negeri 1 Simpang. Out of 66 students, 34 students were selected as sample. The data were taken form questionnaire and oral test. This test was analyzed by using  descriptive statistic, normality, homogeneity, pair sample t-test, independent sample t-test and two-way ANOVA. On tow way ANOVA result by SPSS 22, interaction's score was 0.006 smaller than level of significant score was 0.05. For the result got interaction effect of Digital Storytelling and Motivation on student's speaking ability. Based on data analysis, student's speaking skill taught using Digital Storytelling approach increased significantly. Digital Storytelling was effective to improve student's speaking skill in the experimental group.


Objective:To investigate the therapeutic effect and safety of magnesium sulfate and salvia miltiorrhiza injection on neonatal asphyxia(NA) with myocardial injury.Methods:Twenty-four myocardial injury newborns were randomized into two groups,with 12 cases each.The control group was given Fructose-1, 6-diphosphate(FDP) 250mg·kg~(-1)intravenously for 7 days.The treatment group was given magnesium sulfate(200mg·kg~(-1)intravenously within 30 minutes),followed by maintenance infusion(10mg·kg~(-1)hourly) for 5 days and salvia miltiorrhiza injection(1ml·kg~(-1)) for 7 days.All the cases were finished basing on supportive and symptomatic therapy.The cardiac troponin I(cTnI),creatin kinase__MB(CKMB),creatin kinase(CK) were recorded before and after the treatment for comparison.Results:(1) The cTnI in the treatment and control groups before treatment was respectively 1.83±2.01 ng· m~(-1)and 1.78±1.86 ng· ml~(-1).There was significant difference between the treatment group(0.06±0.02ng·ml~(-1)) and the control group(0.15±0.11ng·ml~(-1)) after treatment.(P0.05).(2) The CK-MB in the treatment and control groups before treatment was respectively 69.3±30.2IU·L~(-1)and 61.7±38.5 IU·L~(-1)(P0.05),and respectively 31.3±12.5 IU·L~(-1)and 43.2±16.8 IU·L~(-1)(P0.05) after treatment,both with marked decrease compared with those before treatment(P0.05).(3) The CK in the treatment and control groups before treatment was respectively 968.3±580.2IU·L~(-1)and 897.5±502.7 IU·L~(-1)(P0.05),and respectively 210.4±178.3 IU·L~(-1)and 357.3±190.2 IU·L~(-1)(P0.05) after treatment.Both had marked difference before and after the treatment(P0.05).Conclusion:The combined therapy of magnesium sulfate and salvia miltiorrhiza injection has definite therapeutic effect on myocardial injury in NA without any obvious adverse reaction.


The invention concerns a method for controlling a parallel hybrid motor vehicle comprising a transmission (12) permanently coupled with an electric engine (18) and a heat engine (14) via a clutch (16), said transmission providing an engine torque to the wheels (20), and comprising an electronic module (30), which, depending on the position of an accelerator (34), controls the heat engine (14), the electric engine (18) and the clutch (16). The invention is characterised in that starting from an initial condition wherein the heat engine (14) is running and the clutch (16) disengaged, the electronic module (30) uses a low speed booster mode, in particular for starting, whereby the heat (14) and electric (18) engines supply at least during a first phase thermal (CMT) and electric (CME) torque respectively according to a distribution ( alpha ) managed by a predefined control law, and whereby the clutch (16) is controlled to be engaged.


The application of coherent change detection has enabled the synthetic aperture radar community to identify manmade changes in repeat-pass imagery not detectable in magnitude only images. In a similar manner, CCD may allow synthetic aperture sonar community to identify man-made changes on the seafloor. We propose a coherent change detection scheme using canonical correlation analysis to determine the linear dependence between the canonical coordinates of the input channels, which are represented by baseline and repeat survey pass of the synthetic aperture sonar. We demonstrate the versatility of this method with application to a synthetic aperture sonar imagery data set with identical trajectory and modest scene change.


Dynamic strength characteristics of frozen silty clay was studied using triaxial cycle tests with the constant stress amplitude under confining pressures varying between 0.3 MPa and 16.0 MPa,at temperatures of-4℃ and-6℃ and a frequency of 2 Hz.It was shown that the dynamic strength depended not only on the number of vibrations and confining pressures,but also on loss of energy resulted from cyclic loading.According to the relationship among the dynamic strength,loss of energy and variation of temperature in specimens,an approximate formula was obtained,indicating that the loss of dynamic strength was influenced by confining pressures and the loss of energy.Thus,one of the key factors controlling the dynamic strength was the raised temperature resulted from the accumulative energy under cyclic loading.


The concept of document modification and the general classification of the modification types are discussed. A method of document protection is proposed based on the use of multi-dimensional numerical linear block error-correcting codes.


The earthquake, which has been occurred on 6 April 2009, has been a catastrophic event for both the city and the University of L'Aquila [1]. Nevertheless, the disaster have to be trans‐ formed in a tremendous opportunity to revitalize the area, with important benefit for the national and international scientific community to experience the effectiveness of new systems and technologies, and consequently to base, on these results, new developments in several different fields.


Dear Editor, Epidermal nevus syndrome (ENS) is a heterogeneous congenital disorder characterized by the presence of epidermal nevi associated with systemic involvement. Keratinocytic epidermal nevus (KEN) syndrome and sebaceous nevus (SN) syndrome are included in ENS which share the same postzygotic HRAS and KRAS gene mutations that are relevant for cell proliferation. A HRAS mutation can induce nevus marginatus, a combined nevus of KEN and SN, and this suggests an identical genetic background of KEN and SN. Here, we report a case of ENS exhibiting both KEN and SN characteristics caused by a novel postzygotic KRAS mutation. A 3-year-old Japanese girl presented with multiple nevoid lesions along Blaschko lines on the left side of her body that she had had since birth. The skin lesions, which were light red at the neonatal stage (Fig. 1a), had transformed into two distinct types: yellowish plaques suggesting SN on the sebaceous gland-rich craniofacial area, and brownish verrucous lesions suggesting KEN on the trunk and extremities (Fig. 1b). Histological evaluation showed papillomatosis and acanthosis with overlying laminated hyperkeratosis (Fig. 1c,d).


quantum enigma physics encounters consciousness is available in our digital library an online access to it is set as public so you can get it instantly. Our books collection hosts in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Merely said, the quantum enigma physics encounters consciousness is universally compatible with any devices to read.


Letter passing on an excerpt from a personal letter that gives the opinion that 5000 plus loyal Nisei currently in the U.S. Army will be turned into "highly trained fifth columnists" due to the actions in the Army against their parents and family and their being discharged.


Let me begin my commentary on Julian Thomas' provocative and stimulating project by invoking, as anthropologists seem to do from time to time, the figure of Sherlock Holmes. Holmes, as we know, classified types of persons, livelihoods, mentalities and criminalities by, among other things, the varieties of dirt on their shoes, the characteristic calluses and grooves on their hands, the imprints they made upon different utensils, the kinds of tobacco, food scraps, and bits of clothing they left behind as traces of their presence. Holmes made a living out of deducing the motivational and moral contours of a human personality from such material indices. He knew the physical components of his environment – the different soils and plants of London, which stores purveyed which implements and goods characteristically utilised by criminals – and he catalogued the sartorial and other visible indices which marked inhabitants of different districts, and socioeconomic and ethnic categories. We also learned that he was not unfamiliar with the Who's Who of London society of his time, not to mention the London constabulary and the organisation of various other professions whose activities related to his interest in crime solving.


Phosphate (P) removal from aqueous solutions were studied by a new mineral adsorbent, tungsten (VI) oxide (WO 3 ) nanoparticles (NPs), which has not been the subject of much research in the field of removing P con - taminants from agricultural wastewater. In this paper, P was removed from aqueous solutions by a new mineral adsorbent, WO 3 NPs and it was compared with magnetite (iron IV) oxide (Fe 3 O 4 ) nanoparticles (NPs) under the same ambient operating conditions i.e

http://www.jeeng.net/pdf-158563-85501?filename=Effect of Magnetite Oxide.pdf


The study was conducted on Lumbricus terrestris (earthworm) in order to determine the level of vehicle derived lead contamination on living. Lumbricus terrestris specimens were analysed for their lead content by using Hitachi (180-70) Polarized Atomic Absorption Spectrophotometer. Lead salts were searched in tissues according to the Rhodizonate Method for Lead Salts. Lead concentrations of the specimens taken from traffic dense areas were higher than the specimens taken from parks.


Concerns have been raised that the transplants performed in the local context at the time of procedures reported in this article [1] may have involved organs/tissues procured from prisoners [2]. The Ethics Statement of [1], declares, "None of the transplant donors were from a vulnerable population and all donors gave their consent freely." However, the authors did not provide ethics approval documentation or consent forms when requested by the journal to support their claims, confirm that the study had institutional ethics approval, and clarify whether organs had been procured from prisoners. Details as to the donor sources and methods of obtaining informed consent from donors were not reported in [1], and the authors did not respond to the journal's queries to clarify these issues or the cause(s) of donor death. International ethics standards call for transparency in organ donor and transplantation programs and clear informed consent procedures including considerations to ensure that donors are not subject to coercion. In addition, the authors did not provide the primary data underlying their article and as such, did not comply with the PLOS Data Availability Policy. Owing to the lack of documentation to demonstrate this study had prospective ethical approval, insufficient reporting, unresolved concerns around the source of transplanted organs and whether they included organs from prisoners, and in compliance with international ethical standards for organ/tissue donation and transplantation, the PLOS ONE Editors retract this article. The authors did not respond to the retraction decision.


Cellulose nanofibrils (CNF) is a renewable material with unique strength properties. A difficulty in CNF production is that CNF suspensions contain large amounts of water. If CNF suspension volume ...


This paper outlines the present state of technical analysis and describes the various mechanisms associated with current practices. In particular, the relative strength analysis approach is identified as a useful tool for investment appraisal. Empirical research on specific technical theories is called for, especially into the relative price behaviour patterns of industrial stocks. Overall, there is seen to be some merit in a proper application of technical theories allied to accurate forecasting of company earnings and dividends.


In my article, Borders: From Community to Nation in Late Medieval Castile, I argue that the development of concepts of sovereignty, national frontiers and a "national" space in late medieval and early modern Castile was linked, among other theoretical and political developments, to the emergence of territorial boundaries and the ordering of physical space at the level of local communities in the late twelfth and early thirteenth centuries. National boundaries, the idea of the realm as a spatial concept, could not have been articulated or imagined without a previous grounding in local experiences. Thus, the main portions of the article explore the transition from definitions of property as seignorial jurisdiction and rents to a spatial ordering of the land in villages throughout northern Castile. Three types of evidence are examined: 1) sources which describe the limiting of geographical space by the use of artificial landmarks ( mojones ); 2) those documents which describe the consolidation of property into contiguous estates; 3) transactions of land which show an increased preoccupation with rights of "entry and exit".


Objective To develop a rapid algorithm in the calculaton of machine monitor units for irregular fields shaped by multileaf collimator (MLC). Methods On considering that the fields' edges are stepwise and the leaves' coordinates can be printed out by a treatment planning system or outlined by a MLC shaper, their area and perimeter can be directly calculated from leaves' coordinates. Then the equivalent field size can be calculated with methods based on the area/perimeter ratio. Finally, the monitor units can be determined from a well-known formula. Results As examples, the total brain-spinal cord field, which was delivered with nominal SSD technique, and head-neck field, which was delivered with SAD technique, were calculated. Conclusions This algorithm is suitable to the situation when the reference point of target dose is located at the central part of a field and has not been blocked. It is quicker and simpler as compared with the other methods such as Clarkson integration.


Fluvial processes of mountain river in the Southeast Tibet have been severely modified by debrisflow dams. However,most of the researches on the debris-flow dammed lake focus on the ancient dammed lake associated with the research on the long-time scale climate change. Researches on the detail fluvial process of debris-flow dammed lake from the short-time scale perspective are insufficient. In this study,we detailed the methodology to extract the sedimentation rate,and the effect of the debris-flow dammed lake on the bed structure is calculated.


We studied double-ionization of H2 and D2 by intense femtosecond laser pulses of different wavelengths (500, 600, 800, 1300, 2000 nm) and peak intensities. The kinetic energy release (KER) spectra measured in the Coulomb explosion of the molecules were used to identify the various mechanisms responsible for the dissociation and ionization of H2/D2 in the laser fields. In addition to fragments from well known bond softening and enhanced ionization channels, high energy protons/deuterons of KER around 11 eV were for the first time observed when using short wavelengths (500 and 600 nm) at highpeak intensities. This channel exhibited wavelength dependence, with KER decreasing for longer wavelengths. This observation implies that a multiphotonionization process is actively operating at short internuclear distances and must be accounted for to correctly understand the strong-field ionization of H2/D2 by short laser pulses. 2 3 4 5 6 7 8 9 10 11 12 13 14 15 0 50


In recent years, a host of companies have tried to bridge the technology gap between home automation systems. This collective effort has led to the development of technologies that have triggered the beginning of device interoperability. A seamless ecosystem is being created that aims to improve comfort for dwellers, improve efficiency of homes, and, as an additional result, will create a massive market for home automation devices. Our research revealed that the home automation market has been growing at an enormous pace and additional integration of technologies would continue to stimulate demand even more, further diminishing costs and thereby reducing the exclusivity of the market by bringing them to the masses. © 2016 Wiley Periodicals, Inc.


In a given population, there is considerable variation between individuals with regard to response to as well as toxicity of different drugs. The term "Pharmacogenetics" has largely been used in relation to genes determining drug metabolism, while "Pharmacogenomics" is a broader based term that encompasses all genes in a genome that may determine drug response. In oncology, efficacy and safety of many chemotherapeutic drugs show substantial individual and/or population variability. It can be explained, to a great extent, by gene polymorphism encoding drug-metabolizing enzymes, drug transporters, and drug targets which influence the pharmacokinetics and pharmacodynamics and affect clinical outcomes. Single nucleotide polymorphisms (SNPs) are the most studied genetic variants at present due to ease, accuracy, and reduced the cost of processing as well as due to public availability of online resources for SNPs. Candidate genes for a therapeutic and adverse response can be divided into three categories: Pharmacokinetic, receptor/target, and disease-modifying. Many anticancer drugs are evaluated for their variation in response according to germline variations. This information can be easily incorporated in day-to-day practice to improve efficacy and/or safety of these drugs. In the future, advances gained from pharmacogenetics research will provide information to guide doctors in advising just enough of the right medicine to a person – The practice of "personalized medicine."


While the capsaicin receptor TRPV1 channel is a polymodal nociceptor for heat, capsaicin, and proton, the channel's responses to each of these stimuli are profoundly regulated by membrane potential, damping or even prohibiting its response at negative voltages and amplifying its response at positive voltages. Though voltage sensitivity plays an important role is shaping pain responses, how voltage regulates TRPV1 activation remains unknown. Here we showed that the voltage sensitivity of TRPV1 does not originate from the S4 segment like classic voltage-gated ion channels; instead, outer pore acidic residues directly partake in voltage-sensitive activation, with their negative charges collectively constituting the observed gating charges. Voltage-sensitive outer pore movement is titratable by extracellular pH and is allosterically coupled to channel activation, likely by influencing the upper gate in the ion selectivity filter. Elucidating this unorthodox voltage-gating process provides a mechanistic foundation for understanding polymodal gating and opens the door to novel approaches regulating channel activity for pain managements.


A method is presented for constructing nonlinear unequal error protection codes. The method uses linear codes as building blocks, thus allowing simple decoding. Comparisons between some two level UEP codes constructed with this method and the direct sum of codes show that these examples perform better than the direct sum of linear codes.<<ETX>>


Interpolation filters are widely used in many communication and multimedia applications. Polynomial interpolation computes the coefficients of the polynomial according to the input information to obtain the interpolated value. Recently, FIR interpolation method using supplementary filters was proposed to improve the performances of polynomial interpolation methods. In this paper, we propose a weighted interpolation method using supplementary filter to further increase the performances of the interpolation filters. Examples and simulation results show that the proposed approach exhibits improved performances compared with the original supplementary filter-based interpolation method.


The overall aim of eumusc.net was to improve musculoskeletal health through evidence-based policy recommendations for the implementation of a Community strategy and by highlighting good practice so that it could be replicated across Europe. It is 3 years since work began on the eumusc.net project and in a month after Eular Congress the project will be completed. Over the 3 years since it began eumusc has produced the first European agreed patient focused Standards of care for RA and OA and tools to ensure their application with equity across Europe. Other important outcomes are advocacy tools to assess and monitor the improvement of health services for people with RA and OA across Europe. In addition, eumusc has agreed on indicators to ensure that health providers are meeting the needs of people with RA and OA and delivering care to the agreed standard, and has studied the barriers and facilitators to achieving these standards to enable the effective and equitable prevention and management of these conditions in the Member States. Disclosure of Interest None Declared


As readers of this journal know full well, the just war tradition has long been a cornerstone of ethical reflection upon the use of military force. Its longevity as a locus for thinking about right and wrong in war is both its strength and weakness. Strength because its heritage has given it weight in a wide range of communities and made it the foundation for the laws of war; weakness because it has become somewhat formulaic, with policy makers turning it into a checklist that can justify uses of military force by referring to vaguely similar precedents or drawing upon obscure thinkers as support for various policies. The world, however, does not fit so well into a checklist. As a result, the real benefit of the tradition is that it provides a starting point for moral reflection upon the use of violence and warfare. As with any good casuistic moral framework which is how I would describe the tradition just war provides principles that cannot be applied mechanically but that need to orient actors and thinkers in their reflections. This can be frustrating to students (and analytic philosophers) who want a just war theory that provides logical answers about what is right and wrong. The tradition can give us that, but only after the hard work of starting with the principles and reasoning through particular situations in order to arrive at measured assessments of the moral status of the use of military force. The Price of Peace, an edited volume that arose from a symposium sponsored by the Church of England and the Catholic Bishop's Conference of England and Wales, provides exactly this kind of approach. The symposium, held in March 2005, was largely a response to the 2003 war in Iraq, along with the issues that have arisen from the 'war on terror' launched since the attacks of September 11, 2001. As a result of this origin, the book includes reflections on the role of just war thinking in the Christian churches; something that is too often left out of scholarly treatments of ethics and warfare. Contributors range from public intellectuals engaged in religious and ethical debate like Jean Bethke Elshtain and George Weigel to theorists of international relations and military affairs such as Gwyin Prins and Mary Kaldor to those engaged in policy advocacy and planning. This range of contributors, crossing disciplinary and professional boundaries, results in an


This paper presents the research about command speech acts in Nawal El-Shadawi's novel Woman at Point Zero. The main reason of the research is to investigate the utterances are important elements in this research because each character expresses different meaning. This research focuses on two main problems: (1) In what context are command speech acts uttered in the Woman at Point Zero's novel? (2) What are the effects of these command speech acts on the hearer in the Woman at Point Zero's novel? The theory used to analyze the data are speech acts from Yule (1996) and Austin (1962), command theory are from Kauffman (2012), and effect theory are from Leech (1993). This research uses qualitative approach by Kothari (2004) for analyzing the data taken from the novel, namely identifying, classifying the data that support the research questions, interpreting the data particularly of speech act based on pragmatics theory. The researcher has found a lot of commanding in Woman at Point Zero's Novel. The totals of commanding speech acts are 17. Overall, the result of this analysis is related to the relation of the utterance with the meaning that wants to convey through that utterance.


Traumatic obturator hip dislocation is rare. It accounts for 6 to 10 % of traumatic hip dislocations. It occurs in the context of violent trauma to a hip in a favourable position. Classically, dislocation occurs when the impact is brought to the anteriomedial part of the knee while the hip is in flexion and the limb in abduction and external rotation. The diagnosis is evoked before a hip deformation in flexion abduction external rotation. Confirmation is made by imaging. We report the case of an unhelmeted motorcycle passenger who allegedly fell from his motorcycle and landed on the anteriomedial side of the knee. The pelvic X-ray showed an obturator dislocation of the left hip. Under general anaesthesia, the dislocation was reduced by performing hip flexion associated with axial traction and then internal rotation adduction. The limb was immobilized in a knee brace for 21 days, bearing allowed after 60 days. At 36 months follow-up, the functional and radiological results are satisfactory.


Cognitive Radio Networks allow unlicensed users to opportunistically access the licensed spectrum without causing disruptive interference to the primary users (PUs). One of the main challenges in CRNs is the ability to detect PU transmissions. Recent works have suggested the use of secondary user (SU) cooperation over individual sensing to improve sensing accuracy. In this paper, we consider a CRN consisting of a single PU and multiple SUs to study the problem of maximizing the total expected system throughput. We propose a Bayesian decision rule based algorithm to solve the problem optimally with a constant time complexity. To prioritize PU transmissions, we re-formulate the throughput maximization problem by adding a constraint on the PU throughput. The constrained optimization problem is shown to be strongly NP-hard and solved via a greedy algorithm with pseudo-polynomial time complexity that achieves strictly greater than 1/2 of the optimal solution. We also investigate the case for which a constraint is put on the sensing time overhead, which limits the number of SUs that can participate in cooperative sensing. We reveal that the system throughput is monotonic over the number of SUs chosen for sensing. We illustrate the efficacy of the performance of our algorithms via a numerical investigation.


The present invention, the following components of the cyclodextrin inclusion compound of a novel 5,10- methylene-tetrahydro-folic acid, i) (6R) -, (6S) - or (6R, S) -5,10- methylene-tetrahydro-folic acid, or (6R) -, (6S) - or (6R, S) -5,10- methylene-tetra hydrochloride salt of folic acid and, iia) -, - or -Cyclodextrin, or -, - or -Cyclodextrin derivative, or iib) -, - or -Cyclodextrin or mixture -, - or A mixture of a cyclodextrin derivative, or -, - or -Cyclodextrin and -, - or - to provide a stable water-soluble composition comprising a mixture of cyclodextrin derivatives. Inclusion compound of the present invention because the stability is extremely good use in pharmaceutical applications. The present invention also provides a use for the manufacture of a manufacturing method thereof, and the drug of the material.


Abstract We construct "self-stabilizing" processes . These are random processes which when "localized," that is scaled around t to a fine limit, have the distribution of an -stable process, where α is some given function on . Thus the stability index at t depends on the value of the process at t. Here, we address the case where . We first construct deterministic functions which satisfy a kind of autoregressive property involving sums over a plane point set Π. Taking Π to be a Poisson point process then defines a random pure jump process, which we show has the desired localized distributions.


CLINICAL neuroendocrinology, encompassing as it does the problems in man of normal and deranged central nervous system control of endocrine function as well as the effects of hormones on the brain, has a long and impressive history dating back at least to the original report of Alfred Frohlich in i90i. Such disorders have always attracted considerable attention not only because of their intrinsic medical interest but also for the promise they hold of providing insights into the mysteries of growth, maturation, and even behavior. It is probably no exaggeration, however, to say that neuroendocrinology has fallen somewhat short of its promise, at least in clinical application. There is need to inquire why this is true and how it may be remedied. There are certain general difficulties inherent in developing any field that straddles several more traditional disciplines, in this case


The fading wire-tap channel is investigated, where the source-to-destination channel and the source-to-wire-tapper channel are corrupted by multiplicative fading gain coefficients in addition to additive Gaussian noise terms. The channel state information is assumed to be known at both the transmitter and the receiver. The parallel wire-tap channel with independent subchannels is first studied, which serves as an information-theoretic model for the fading wire-tap channel. The secrecy capacity of the parallel wire-tap channel is established. This result is then specialized to give the secrecy capacity of the fading wire-tap channel, which is achieved with the source node dynamically changing the power allocation according to the channel state realization. An optimal source power allocation is obtained to achieve the secrecy capacity.


ABSTRACT This article deals with two aspects of relocation of custodian parents and their children. The first part addresses the formulation and interpretation of the best interests test by South African courts in relocation cases. It examines the factors which courts take into account, their interpretation and the weight afforded to them, focusing particularly upon the consequences for custodian parents. The aim of this analysis is to determine whether there is any consistent principle or policy which animates and directs jurisprudence in this area. The second part of the article isolates the various constitutional rights and interests which should be taken into account in relocation cases, focusing particularly on ways to reconcile the interests of parents with the best interests of children. It is suggested that a policy should be adopted and legislation amended to reflect the connections between the interests of children and those of their parents. The policy should favour relocation, unless it is clear that this would be contrary to the interests of children.


Abstract : A crucial question in the evaluation of the importance of arctic resources to the countries concerned, including the United States, is the feasibility of economic transportation of the resource to non-arctic markets. In view of the above factors this survey of arctic resources is mainly confined to the resources of the arctic regions, or collection points which are in the Arctic and must operate under arctic conditions. It appears that major interest lies in the field of energy fuels. This situation results mainly from the anticipated heavy future demands of industrial society. The interest in the Arctic is whetted in turn by indications that the arctic region is, in fact, rich in precisely those resources. The resource survey, therefore, emphasizes energy fuels of the region, which means mainly its oil and gas resources.


Ion irradiation plays an important role to tailor the microcrystalline structure and the corresponding magnetic anisotropy by high local energy deposition and defect accumulation. In the present work, we have investigated the effects of nuclear energy loss and electronic energy loss on the phase transformation and magnetic anisotropy of thin polycrystalline Co films. As-deposited film shows polycrystalline behavior with twofold uniaxial magnetic anisotropy, characteristic to hcp-Co film. 320 keV Au ions induce phase transformation from hcp to fcc. Similar phase transformation have been observed in the case of film irradiated by 120 MeV Au ions. Rate of phase transformation is discussed in terms of electronic and nuclear energy losses and the corresponding changes in the magnetic anisotropic behavior are discussed in the light of uniaxial and fourfold magnetic anisotropy.


Hybrid simulation is a powerful test method for evaluating the seismic performance of structural systems.Thismethod makes it feasible that only critical components of structure be tested experimentally while the rest of the structure is numerically modelled. This paper presents a newly proposed integration algorithm for seismic hybrid simulation which is aimed to extend the capabilities of hybrid simulation to a wide range of systems where existing methods encounter some limitations. In the proposed methodwhich is termed Variable Time Step (VTS) integration method, an implicit scheme is employed for hybrid simulation by eliminating the iterative phase on experimental element, the phase which is necessary in regular implicit applications.In order to study the effectiveness of the VTS method, a series of numerical investigations are conducted, in them the restoring force of the column is assumed to be achieved experimentally. The results show the successfulness of VTS method in obtaining accurate, stable and converged responses.Also in a comparative approach, the improved accuracy of VTS method over commonly used integration methods isdemonstrated utilizing two error indicators.


Thioctic-(13-biotinoylamido-4,7,10-trioaxatridecaneamine)amide were synthesized by thioctic acid,diamine with ether linkage and biotin.The molecular structures of the intermediates and the target compounds were confirmed by 1HNMR,GC-MS and FT-IR.All kinds of biotinylated molecules can be synthesized by change the side of biotin.Thus applications and kinds of the material of biotin-avidin/streptavidin/neutravidin assembled systems were increased.This assembled systems have many applications in the fields.


High power-density motors and generators and reliable high power solid state motor speed controls make electric drives an attractive contender for naval propulsion systems. This paper presents several modeling techniques and scaling relationships to assist others in estimating the volumes and weights of propulsion generators and motors, solid state power conditioners, electrical switchgear, and associated electrical propulsion system components as functions of propeller shaft power. These modeling and scaling relationships are applied to a specific watercooled conceptual design propulsion plant to demonstrate the scaling method and to present the sizes and weights of "state-of-the-art" components for propulsion systems in the 22 to 52 megawatt (30,000 to 70,000 horsepower) per propeller shaft range. Although the conceptual design discussed reflects watercooled technology, the provided relationships can be used for any given machine or machinery system configuration as long baseline data is available. For the purposes of this paper, some aircooled data is presented and the results compared to a specific watercooled Advanced Integrated Electric Propulsion Plant (AIEPP) design which was presented at ASNE DAY 1982 and published in the April 1982 issue of the Naval Engineers Journal. This paper permits application of the previously published AIEPP technology to a wide range of shaft horsepowers and propulsion plant configurations and thus serves as a major extension of the basic concepts set forth in the April 1982 paper for advanced alternating current electric drive machinery.


Chronic limb ischemia is a progressive and life threatening disease which in turn effects on quality of life. Up to date several studies have been conducted to timely identify and manage of the disease. Timely identification, diagnosis and treatment of this pathological condition will play crucial role to reduce burden in healthcare associated with this disorder. In this article latest data are shown on chronic limb ischemia, its pathophysiology, and treatment and prevention measurements together with general information on this disorder. Furthermore, latest clinical trials and studies are summarized in order in depth understand the exact mechanisms of the disease.


The voltage range of integrated oscillators will be excess than desired due to process and temperature variations, which will lead to phase-noise. In this paper a dual-mode LC-tank based VCO with active core reconfiguration is designed to allow two distinct modes of operation, with different oscillation frequencies which reduces phase noise with tuning ranges of 28% .The design is implemented in a 180nm CMOS technology and simulated using Advanced Design System tool, with measured tuning ranges of 56.9 GHz to 65.4 GHz, and 64.6 GHz to 75.3 GHz in the two modes respectively. This design ensures the overlapping of two oscillation mode frequency spans to reduce each frequency span phase noise problem. This design is very useful and recommended for radar applications.
Index Terms --- Dual-mode oscillator; phase noise; tuning range; varactor; VCO


Ariela Gross offers a thorough summary of points made in the two articles in this Forum, and integrates the articles well. As she notes, taken together, they provide an examination of the "other white" litigation strategy employed by Mexican American civil rights lawyers.


Objective: Children with ADHD have been widely reported to overestimate their abilities in social and academic domains, but a similar overestimation of physical abilities has not been examined. Method: Twenty-four elementary school-age boys with ADHD and fifteen boys without ADHD were compared on their ability to accurately estimate their ability to complete four lab-based physical tasks, varying on three levels of difficulty: (a) within their ability, (b) 8% beyond their ability, and (c) 13% beyond their ability. Results: Children with ADHD were significantly more likely than controls to overestimate their physical ability at difficult levels of the task. Conclusion: Implications of these results for preventing risky behaviors in children with ADHD are discussed.


Abstract : Despite dire predictions from the federal government, academia, and private research institutions about the threat posed by nuclear and radiological terrorism, the federal government has yet to develop an overarching organizational framework to collectively plan and prepare for the horrendous consequences of such an attack. In addition, the federal government has yet to develop even a modest program to provide technical planning and preparedness assistance to those local officials charged with coordinating the response to nuclear or radiological terrorism the local emergency manager. In order to reduce the loss of life, social panic, and the direct and indirect economic loss caused by a nuclear or radiological terror attack, the federal government should pursue the creation of a suite of strategic national and regional organizational innovations designed explicitly to prepare our nation's emergency management community and other first responders for their critical roles during a large-scale radiological response. First amongst these innovations should be the promulgation of a new Homeland Security Presidential Directive establishing a Domestic Nuclear Preparedness Office. Such organizational improvements, coupled with an aggressive field-level technical assistance planning, training, and exercise outreach campaign, will enable the United States to build a sophisticated and coordinated nuclear and radiological terrorism preparedness and response system.


Summary. - A survey of the Agariceae in Brasil and adjacent countries between the Tropic of Capricorne and the North of South America, including the Lesser Antilles, brings to an end the series of Agarici Austroamericani. Are signalized 92 taxa some of which are fully described from local collections. Agaricus meijeri (p. 368) is a new species. A general index (p. 379) recapitulates all the taxa treated in the series (over 200 names). Ce travail clot la serie des Agarici Austroamericani. II concerne specialement les especes reconnues entre le tropique du Capricorne (mais aussi la partie du Bresil situee au sud de ce parallele) et le nord de l'Amerique du Sud y compris les Petites Antilles. Il comporte en outre des complements sur les contributions precedentes et un index general.


I came across Louis Helbig's images on the web one Sunday morning, about two years ago. Sitting at my kitchen table, I called him up to express my admiration for the photographic work. Like Peter Gzowski's old CBC Morningside radio show, he picked up the phone in his kitchen and we talked for a couple of hours, swapping perspectives on the political, cultural, and environmental issues swirling around the tar/oil sand developments. We hit it off, exchanging ideas about the beauty of industrial landscapes and the loss they also represented. We exchanged hope that his photographs might provoke a broader critical conversation about what was happening in northern Alberta.

This interview took place in late 2011. Louis and his photographs had been discovered. We talked about the public reaction to his images of the tar sands, and we chatted about the direction his new work was taking.
I hope that you share my delight with the sharp perspectives of this creative aerial photographer, who is passionate about nature, and questions the heavy footprint we are leaving on the Canadian landscape. Louis read over the Aurora transcript and selected some of his photographic images to illustrate his thoughts and responses to our questions.


Conventional ventilation methods often supply fresh air to the room with a steady supply flow rate, which might induce stagnant recirculation cells and stagnation zones that are characterized by high concentrations of contaminants. This paper presents computational fluid dynamics (CFD) simulations of isothermal mixing ventilation with a transient supply flow rate in a generic room. The time-periodic supply flow rate is described by a sine function with different amplitudes. It is shown that time-periodic forcing triggers the stagnant recirculation cells to continuously shift throughout the room, thereby reducing average (passive gaseous) concentration levels in the occupied zone volume compared to the steady supply of fresh air. The concentrations are lower when larger amplitudes are applied. The analysis indicates a reduction in contaminant concentration by up to 24% and an increase of the contaminant removal effectiveness by 24% for time-periodic supply conditions compared to steady supply, which offers new perspectives on healthy and sustainable ventilation for, among others, residential buildings, office rooms, ship cabins, train cabins and cars.


791 Background: Breast cancer has a significant capacity to metastisizemetastasize to bone. Bisphosphonates are the standard treatment for hypocalcaemia of malignancy (HCM), which is a common complication of bone metastasis. The combination of bisphosphonates with standard anticancer drugs like paclitaxel or tamoxifen results in a synergistic apoptotic effect greater than that produced by either single agent alone.

METHODS
Potential antitumour effects in vitro of two bisphosphonates: Ib and Zol (each at 30 μM) combined with different anticancer drug combinations: cyclophosphamide/metotrexate/5-fluorouracil (CMF), epirubicin/cyclophosphamide (EC), epirubicin/paclitaxel (ET), and epirubicin/ docetaxel (EDoc) have been investigated using ATP-CVA. 20 cases of female primary, invasive breast cancers have been assessed. Percentages of total growth inhibition (TGI) were calculated according to the formula: 1-(TDC-MI)/(MO-MI) x 100 = %TGI. AUC values were calculated using the trapezoidal rule. Chemosensitivity was defined as AUC of more than 18000. Statistical significance was assumed if p was < 0.05 Results: Ib and Zol alone have shown inhibitory effect on breast cancer tumour cells in vitro. BTGI effect for those two drugs amounted to 22 and 25%, respectively. Inhibitory effects were clearly visible for all four combinations of anticancer drugs together with both bisphosphonates. In all cases, the differences between measured TGI values for drugs' combinations alone in comparison to drugs with IB or Zol were statistically significant. Addition of Zol to CMF or ET revealed higher median of TGI than EC or ET plus Ib. In the lowest dose of anticancer drug concentration (6.25%), enhancing effects of Zol and Ib on TGI were clearly visible in all combinations. Addition of Zol enhanced the chemotoxic action of CMF and ET better then Ib (p= 0.03) Conclusions: Combinations of anticancer drugs with Zol seem to be more effective in respect to tumour growth inhibition than combinations with Ib, at least in case of CMF or ET in the lowest dose concentrations of those antitumour drugs. No significant financial relationships to disclose.


a CI, confidence interval; OR, odds ratio. anism had been induced. Given the rapidity with which resistance to HIV-1 appears to have been lost after brief interruptions of sex work by the Nairobi cohort [7], initial protection against infection was most likely stochastic. A similar phenomenon may apply to cohorts of HPV-negative and HHV-8–negative women with multiple sex partners. But, perhaps, as a result of the good fortunes of the women in the Nairobi cohort who did not become infected, we will be able to learn something applicable to the development of vaccines against certain sexually transmitted diseases.


It was aimed to analyze the characteristic the soil cover and plant height of six irrigated grasses under different nitrogen and annual seasons. The experiment was conducted in a split plot design, tends a factorial design 4 x 6 (nitrogen and grasses) in the plots and season (autumn/winter and spring/summer) in the split-plots, in a completely randomized block, with four repetitions. The nitrogen's was of 100, 300, 500 and 700 kg ha ano and the grasses were: Xaraes, Mombaca, Tanzania, Pioneiro, Marandu and Estrela. The height was measured from the soil to the extremities of the leaves and the soil cover of the esteemed visually by three observers. The results showed that occurred effect the grasses, nitrogen and annual seasons in the two appraised characteristics. The grasses that provided larger soil cover to the Estrela followed by Marandu. Pioneiro and Marandu presented larger and smaller plant height, respectively. The spring/summer season provided larger plant height, even so it didn't influence the soil cover. In the autumn/winter season, the nitrogen provided increase and reduction in the soil cover of the Pioneiro and Tanzania, respectively. The nitrogen just provided increase in the Pioneiro's height.


The most effective method for relieving stress on foam encapsulated solder joints caused by thermal cycling is using silicone sleeving over component lead wires. The use of 128 kg/m/sup 3/ (8 lbs/ft/sup 3/) polyurethane foam rather than 320 kg/m/sup 3/ (20 lbs/ft/sup 3/) foam was advantageous only when the component leads were not sleeved. Special lead configurations were no better than a standard 90 degree bend. None of the other methods used or devices tested was better than silicone sleeving.


The sulfur vulcanization of polyisoprene accelerated by 2-bisbenzothiazole-2,2′-disulfide (MBTS) was investigated. Rubber compounds were heated in a DSC and removed at various temperatures along the DSC thermal curve. The rubber vulcanizate was analyzed for crosslink density and for residual reactants and extractable reaction products. MBTS reacts readily with sulfur, and the polysulfidic accelerator complexes react with the rubber chain to form pendent groups. Crosslinking results from hydrogen abstraction, by the benzothiazole pendent group, from a neighboring chain. 2-Mercaptobenzothiazole, a product of crosslinking, also acts as an accelerator in the later stages of the reaction. MBTS has been shown not to react with ZnO and the higher crosslink densities obtained when ZnO is present are attributed to ZnO aiding the abstraction of the benzothiazole pendent group to give zinc mercaptobenzothiazole. A mechanism for the MBTS acceleration of sulfur vulcanization is proposed. © 1996 John Wiley & Sons, Inc.


Software reliability has been regarded as one of the most important quality attributes for software intensive systems, especially in defense domain. As most of weapon systems complicated functionalities and controls are implemented by software which is embedded in hardware systems, it became more critical to assure high reliability for software itself. However, many software development organizations in Korea defense domain have had problems in performing reliability engineered processes for developing mission-critical and/or safety-critical weapon systems. In this paper, we propose an effective framework with which software organizations can identify and select metrics associated software reliability, analyze the collected data, appraise software reliability, and develop software reliability prediction/estimation model based on the result of data analyses.


Acinetobacter spp. has been increasingly reported as important nosocomial pathogen worldwide. Among the species of this genus, A. baumannii has excelled like an important opportunistic pathogen, responsible for infections related to health assistance (IRHA). In Brazil, this microorganism is a cause for concern because of their high prevalence in hospitals and multi-resistance to antimicrobials. According to the latest report of the National Health Surveillance Agency (Anvisa), in 2013, A. baumannii was ranked as the fourth most prevalent pathogen among intensive care unit's patients (ICU). In this study, our objectives were to confirm the clinical identification of 92 isolates that were collected from two public hospitals in Rio de Janeiro, during a period of one year, for this, we used biochemical and molecular methods. In addition, we characterized phenotypically and molecularly antimicrobials resistance to determine the genetic diversity and to assess virulence factors of these isolates. Sequence analysis of the rpoB gene was performed to confirm the identification of all clinical isolates as A. baumannii. Furthermore, in 93.5% (n=86) of isolates was checked multidrug resistance (MDR) profile. Among the MDR isolates, 93% (n=80) were resistant to cabapenemas (imipenem and meropenem) and 80.2% (n=69) were resistant to polymyxin B, for this antimicrobial, the isolates exhibited Minimum Inhibitory Concentration (MIC) values between 4 - 64 g/mL. By PCR, we verified that all the isolates had blaOXA-51 gene and the insertion sequence gene ISAba1, 93.5% (n=86) had the blaOXA-23 gene and there was no detection of blaOXA-24 genes, blaOXA-58, and blaOXA-143. Among the 12 isolates sensitive to imipenem, 51.6% (n=5) had the blaOXA-51 gene, blaOXA-23 and ISAba1. Through the analysis of genetic polymorphism of these isolates by PFGE, we noted the presence of 22 clones (A to U), two prevalent clones, A (30.4%, n=28) and B (18.5%, n=17), that were present in two hospitals studied. The ability of the 92 isolates to form biofilm was also evaluated, in this study, we observed biofilm production by 79.3% (n=73) of isolates. One isolate representative of each clone prevalent (A and B) and four sporadic clones (C, D, E and F) isolates, were selected to evaluate the degree of association, by optical microscopy, to A-549 and HEp-2 cells. In general, when we compared this association, we observed a higher association with HEp-2 cells. After we realized the counting of colony forming units test (CFU), we suggest that the isolates of A. baumannii are able to adhere but not invade HEp-2 cells. Finally, when we assessed the cell viability by enzymatic reduction reaction of metiltetrazolio salt (MTT), we notes consistent results with the results observed by optical microscope. This study may assist the monitoring of resistance, knowledge of the molecular epidemiology and understanding of the A. baumannii pathogenicity. From these results, we can implement control measures to protect and promote the health of the population.


Based on the field monitoring data of ice-induced vibration,the necessity of dynamic evaluation for ice-resistant jacket platforms is discussed,and the dynamic failure mode under dynamic ice force are analysed.It is brought forward that the dynamic failure mode mainly includes acceleration failure mode and fatigue failure mode.Moreover,the method of computing ice force spectrum for vertical structures is introduced.As an application example,the finite-element model of Jz9-3GCP platform is built with ansys structure software and the structural characteristics is analysed.At the same time,dynamic safety assessments for the structure are carried on.The method will be helpful to the design and safety assessment of ice-resistant jacket platforms.


This Non-Destructive Evaluation of Power transformer by monitoring various parameters, to predict its in-service behavior, is very much necessary for an operating engineer to avoid catastrophic failures and costly outages. Majority of the power transformers are filled with fluid that acts as a dielectric media, an insulator and as a heat transfer agent. During the service, there is usually a slow degradation of the mineral oil and the solid insulating materials, leading to the generation of certain gases, that gets dissolved in the oil. However, when there is a fault, these gases are generated at a faster rate. Dissolved Gas Analysis (DGA) is an important tool for transformer fault diagnosis. It is observed that the results of DGA doesn't have a perceivable change over a short period. For less population of data availability grey modeling is used. To apply probability theory, statistics, and fuzzy systems, there is a requirement for a large number of data, then only conclusion or some inference can be drawn. The advantage of using the grey system theory is that, it gives a fair accuracy in predicting the volume of the gases, expected to be generated after some time period, using a small sample of data. In this paper we have done a comparative study on the predicted results obtained by different model of Grey theory mainly whitened model, connotation model and modified grey model. It is found that the error generated from the prediction by all the three models are within the limit of 15% which is acceptable. Additionally, by studying the behavior of the gases and by applying linear regression we have established a correlation between the key gases. This helps us to detect the abnormality of the condition and diagnose the type of fault . Key-Words: Dissolve gas analysis, Grey model, Modified grey model, Regression theory, Correlation,Fault diagnosis.


This thesis is a very interesting exploration of the novel Oliver Twist, which has as its focus Dickens's portrayal of the London underworld. The thesis is sensitive in its analysis of the book and very well written. It also uses a number of interesting sources, in particular the novelist George Gissing's penetrating study. The author first outlines the reality of underworld life in the 1830s and then discusses a controversial aspect of the book, namely the anti-Semitic portrayal of the character Fagin. She then turns to an examination of the main characters of the novel, as 'characters of the underworld'. Her conclusion points out that Dickens used the novel to both illustrate social wrongs, specifically the Poor Law Amendment, and also to make moral points, e.g. through the virtuous character of Oliver as an example to the poor, and that the novel also shows the opinions of Dickens, some of which reflect the anti-Semitism of the times. The final paragraph of the conclusion draws attention to the limitations of the novel – the prevalence of coincidence and the flatness of many of the characters – whilst claiming that Oliver Twist provides one of the most vivid portrayals of the London underworld.


The photogalvanic behaviour of iron-thionine and iron-methylene blue systems in the presence of surfactants has been studied. The data indicate that the surfactant micelles can be utilized for the storage of light energy.


A team of UK geologists from Durham and Oxford universities has discovered one of the world's largest helium gas fields using a new exploration technique.


objective To study diffusion weighted magnetic resonance imaging(DWI)and perfusion weighted magnetic resonance imaging(PWI)features of primary intracranial lymphoma.Method The DWI features were retrospectively analyzed in 10 cases of primary intracranial lymphoma proved by operation and pathology,while PWI features of 9 cases were retrospectively studied.The comparison with 21 cases of high grade(Ⅲ,Ⅳ) astrocytomas were performed in combination with their histopathological characteristics.Results The lesions of primary intracranial lymphoma usually showed high signal on DWI,and the apparent diffusion coefficient(ADC)value of primary intracranial lymphoma was(79.73±10.21)×10-5mm2/s,and the comparison with a group of high grade astrocytomas showed a statistical significance in the ADC value(99.81 ±19.57)×10-5 mm2/s(P=0.002).PWI features showed that the maximum rCBV ratio of primary intracranial lymphoma in tumor parenchyma was 1.71±0.59,while that of high grade astrocytomas was 5.17±1.73.The primary intracranial lymphoma had a tendency to have low perfusion compared with high grades astrocytomas(P=0.001).Conclusions DWI and PWI can be useful in distinguishing primary intracranial lymphoma from high grades astrocytomas.Combining with the conventional MRI appearance with DWI and PWI features can improve MRI diagnostic accuracy of primary intracranial lymphoma.

Key words:
Brain neoplasms; Lymphoma; Magnetic resonance imaging; Diffusion-weighted magnetic resonance imaging; Perfusion-weighted magnetic resonance imaging


Prsent studies on industrial manipulator control either completely neglect structural flexibility or only consider manipulator link flexibility. Ignoring joint flexibility may cause significant errors in gross motion control if the joint elastic effect is predominant. A control scheme that can effectively compensate for the motion disturbances due to simultaneous existence of link and joint flexibility is presented. The manipulator dynamics is first formulated by a superposition of two models. An assumed modes of vibration is proposed to model the flexible links and a linear torsional spring to model the elastic joint. Then, a non-linear feedback rate servo control system is developed that compensates for the gross motion bias introduced by both joint elasticity and link flexibility. Motion simulation results show that the proposed modelling technique can effectively describe the dynamic behaviour of a flexible-link, elastic-joint robot. They also verify that the proposed controller is robust in that it c...


Thermal issues are usually the limits for the performance of industrial products.In this paper,a temperature calibration procedure has been analyzed for a thermal controller that is developed in ABB Corporate Research.For the convenience of thermal sense and control,the developed thermal controller integrates the sensor conditioning and actuator driving together.The Netduino based architecture enables the thermal controller to be flexibly programmable,remotely accessible via Ethernet,and easily implementable with plug-and-play feature.In particular,a temperature sensor calibration procedure with both hardware setup and software processing has been presented.Temperature sensing control experiments are reported and analyzed to show the calibrated thermal controller are reliable with sufficient accuracy.


Have you familiarized yourself with the ASCPT 2015–2020 Strategic Plan, which was officially unveiled at the 2015 Annual Meeting? The new Strategic Plan, entitled, "ASCPT: Transforming Translation" is now available on the www.ascpt. org website and we encourage all of our members to take a look and see what the Society will work to achieve over the next 5 years. With this plan, ASCPT sees continued opportunity to leverage our strategic positioning as the leading multidisciplinary professional organization in clinical pharmacology, translational medicine and therapeutics. Efforts are already under way to achieve the goals of the new plan, so take a look today!


Cosmic inflation driven by the vacuum energy associated with the $D$ term of a supersymmetric Abelian gauge group and a possible existence of long-range force mediated by an ultralight gauge boson ${Z}^{\ensuremath{'}}$ are two extreme examples of models based on extra $U(1)$ symmetries. Large vacuum energy sets the scale of inflation while the scales of long-range forces induced by anomaly free extra gauged $U(1)$ symmetries are constrained by neutrino oscillations, binary pulsar timings, and invisible neutrino decay. There exists a difference of about 40 orders of magnitude between the scales of these two. Also, gauge couplings associated with the long-range forces are very small compared to the standard model couplings and the one required for inflation. We propose a framework based on clockwork mechanism in which these vastly different scales and associated new physics can coexist without invoking any arbitrarily small or large parameter in the fundamental theory. A chain of $U(1)$ is introduced with characteristic nearest-neighbor interactions. A large $D$ term introduced at one end governs the dynamics of inflation. ${Z}^{\ensuremath{'}}$ is localized on the other end of the chain, and it can be massless or can get naturally suppressed mass. The standard model fields can be charged under one of the intermediate $U(1)\mathrm{s}$ in the chain to give rise to their small effective coupling ${g}^{\ensuremath{'}}$ with ${Z}^{\ensuremath{'}}$. Constraints on ${g}^{\ensuremath{'}}$ and ${M}_{{Z}^{\ensuremath{'}}}$ are discussed in the context of the long-range forces of type ${L}_{\ensuremath{\mu}}\ensuremath{-}{L}_{\ensuremath{\tau}}$, ${L}_{e}\ensuremath{-}{L}_{\ensuremath{\mu}}$, and $B\ensuremath{-}L$. These, along with the inflation observables, are used to constraint the parameters of the underlying clockwork model.


Changes in production practices, as from conventional tillage to minimum tillage, might affect allelopathic interactions between different crops residues below the Cuban productions systems. Field experiments were conducted on typical Red Ferralitic soil in the Agricultural Enterprise April 19, of municipality Quivicán, Mayabeque province, Cuba, during two years. The objective was: to evaluate the influence of minimum tillage systems and the allelopathic effects on the common beans (Phaseolus vulgaris, L) productions cv Tomeguín 93-N. The residues were sweet potatoes (Ipomoea batata, L) cv CEMSA 78354, corn (Zea mays, L) cv. Francisco, sunflowers (Helianthus annus, L) cv CubaSol and commom beans (Phaseolus vulgaris, L) cv Tomeguín 93-N. These residues were incorporated into the soil a ration to 0,3 kg m2. The treatments study objects were the result of the four vegetables residues incorporated and the control the treatments were arranged and the random block with four replicas. The observations and determinations were: survival of the plants (reduction percentage), yield (t ha-1), and analyze of cost and crops common beans utility. The results indicated the negative influence of minimum tillage systems in the survival of the plants and yield of common beans (Phaseolus vulgaris, L) cv Tomeguin 93N as consequence the allelopathic effects of such residues.


As one of the leading figures in nineteenth century school music in Victoria and more widely in Australia, Samuel McBurney contributed significantly to the promotion of Tonic Sol-fa as a music teaching method as well as to supporting the role of music as a subject in the school curriculum. However his role also extended to that of composer of vocal and choral works for both adults and children. Although largely conforming to the established genre of choral writing of his time, McBurney's compositional output nevertheless represents a variety of styles ranging from lieder to school and popular songs, and from children's cantatas to celebratory and patriotic anthems. This paper considers a representative sample of McBurney's compositional output in the light of both its musical and extra-musical content. It is argued that his compositions represent several important themes that emerged in Australian colonial society during the latter part of the nineteenth century. His music contributed not only to the moral and aesthetic development of school children but also supported the growing tide of nationalism (which resulted in Federation in 1901) in adult choral music making. Moreover, particularly in relation to his school cantatas, McBurney continued the tradition established by earlier school music composers in Australia - such as James Fisher in New South Wales - by providing a repertoire of choral music for use in schools which, to the present day with the current vogue for school musical productions, continues to be a source of enjoyment, celebration and 'healthful recreation' for young people.


DURING THE TWENTY-FIVE YEARS before Confederation religious tensions were conspicuous in Canadian politics. Long-standing differences between the French and English races, and between Protestants and Roman Catholics, were aired on the hustings, in the legislature, and in the press. George Brown, who had been personally involved in public affairs in this period, looked back upon it in 1871 as a period in which "religious sects were arrayed against each other, clergymen dragged as combatants into the political arena, religion brought into contempt."1 The Protestant minority in Canada East and the Roman Catholic minority in Canada West were exhibiting symptoms of hypersensitivity concerning the possible perils of domination by a majority hostile to their interests. The French Roman Catholic majority in Canada East and the British Protestant majority in Canada West were frequently aligned against one another. In an editorial in March 1858, the Canadian Presbyter lamented that for some time past the two provinces had been involved in an unhappy rivalry. After mentioning some of the issues on which the people of the two provinces were divided the writer went on to say that the basic issue dividing them was the difference in religion:


When material properties depend much on positions in a material or it is difficult to make test specimens from a material or component, an instrumented indentation test described in ISO 14577-1, 14577-2 or KS B 0950 can be used to measure material properties and damage. In this study, first of all, the principals of the instrumented indentation test, KS B 0950 are introduced and yield strengths, tensile strengths and work hardening exponents of base materials, heat affected zones and weld materials are measured. In addition, the influence of post-weld heat treatment on the material properties is investigated. Finally the fatigue life of butt welded specimens are evaluated by the local strain approach. To calculate local strains and stresses, elasto-plastic finite element analysis is conducted using the measured properties.


Many second order mechanical systems have components subjected to viscous friction. The prediction of dynamic characteristics of such systems involves inclusion of a force term due to friction. When the velocity of sliding is high and constant, the standard models of fluid film lubrication can be employed for this purpose. However, when the sliding velocity is low, and also variable, such standard models cannot be employed. In such situations the behaviour of the mechanical system becomes uncertain due to presence of friction. For a particular system one has to identify a particular model, which gives the best analytical results, as compared to practical observations. In the present work the dynamics of a hydraulic actuator is obtained by simulation by the Lugre friction. The mechanical system used for such simulation is a one-degree-of-freedom second order system. This study is useful in understanding the relative discrepancies, which may arise due to use of different friction models. One can compare the experimental data for a particular application with these results, in order to determine which particular model is in best agreement with the experimental results.


The invention relates to an apparatus for producing corrugated honeycomb cardboard (1) with a block supplying means (16) for feeding blocks (2) of corrugated board along a transport direction (8), a cutting device (11) for cutting strips (12) of a block (2) of corrugated cardboard, a gluing device (14) for applying glue to at least one side of the strip (12), a corrugated strip turning device (15) for changing the spatial orientation of the strips (12) and a joining device (82, 84) for adhesively bonding together the strip (12) to form corrugated honeycomb cardboard (1).


Efficient energy storage is very important nowadays due to the extensive development of renewable energy options with fluctuating outputs. Available energy storage technologies have distinct charge and discharge efficiency depending on the technology involved. In this paper, we present a generalized optimization model for cost minimization in combined energy production and storage facilities. The model can incorporate any combination of dynamic supply, storage, and energy-intensive product demand.


This paper empirically analyzes the percentage of independent directors in board of directors and effects of the incentive mechanism on enterprise efficiency by Stochastic Frontier Approach model. Result show that,the percentage of independent directors in board of directors has no evidently and positively effect on the enterprise efficiency raising; subsidies for independent directors work as a positive factor to boost the enterprise efficiency. Therefore,rasing subsidies for independent directors is beneficial to a stable development of enterprise in a long run.


Summary form only given. The Helicity Injection Tokamak (HIT) has been upgraded to the "HIT-II" configuration. HIT-II extends coaxial helicity injection (CHI) to time scales longer than the wall resistive diffusion time. Previous results on HIT include production and sustainment of up to 250 kA of toroidal plasma current by CHI, without a transformer. HIT-II has approximately the same shape as HIT; major radius R=0.3 m, minor radius a=0.2 m with an co-axis toroidal field of up to 0.67 T. The 1 cm copper shell of HIT is replaced in HIT-II by a 6 mm stainless steel shell. Equilibrium fields are provided by 28 feedback controlled poloidal fields coils. These coils also provide programmable control of the magnetic flux boundary conditions for CHI current drive and are capable of 100 mWb of transformer flux swing. HIT-II has a graphite inner electrode and uses boronization and helium discharge cleaning for wall conditioning.


The results from a raising seedlings experiment of Keteleeria davidiana show that its germinating rate,planting percent and seedling quality are improved by accelerating germination,drilling seed and shading properly and the germinating rate,average height and diameter of yearling are up to 48.2%,10.1cm and 0.35cm respectively.


Spar technology has been applied to the deep-sea oil and gas exploitation for several years.From the first generation of classic spar,the spar platform has developed into the second generation of truss spar and the latest cell spar.Owing to its favorable adaptability to wide range of water depth and benign motion performances,spar has aroused quite a lot of interests from oil companies,universities and research institutes.In the present paper,a new cell-truss spar concept,put forward by the State Key Laboratory of Ocean Engineering(SKLOE)at Shanghai Jiao Tong University,is studied both numerically and experimentally.The numerical simulation was conducted by means of nonlinear time-domain fully coupled analysis,and its results were compared to the experimental data.Whereafter,detailed analysis was carried out to obtain the global performances of the new spar concept.Proposals for the improvement of numerical calculation and experimental technique were tabled meanwhile.


The Hood Museum of Art at Dartmouth College, one of the oldest and largest college museums in the country, is comprised of more than 65,000 objects from around the world made in a wide range of types, styles, origins, and media, with some regional collections being almost encyclopedic. In more recent years, the Hood has begun to expand its collecting interests to include not just ancient and historical works created in "traditional" African cultural contexts, but also works by contemporary artists living in and away from Africa. This new direction poses significant challenges to the larger conceptual and practical framework not only of the Hood Museum of Art, but also broader museum practices in general. This essay will focus on the Hood's activities over the past five years in questioning its own collection and exhibition practices. Providing individual case studies of experimental strategies and practices recently used at the Hood, this essay will reveal the slippery slope upon which museums stand today in redefining their ideologies and practices in an ever-diversifying and "globalized" art world.


Ferritic stainless steel having an excellent oxidation resistance, excellent high temperature strength, and excellent moldability is produced by using the addition of Ti and low A1 content to room temperature formability derived from cast equiaxed grain structure. The call rumbyum (niobium), and copper is added to the high-temperature strength. The silicon and manganese are added to the oxidation resistance. The ferritic stainless steel provides better oxidation resistance than the ferritic stainless steel of 18Cr-2Mo and 15Cr-Cb-Ti-Si-Mn. In addition, the ferritic stainless steel is prepared generally cheaper than 18Cr-2Mo.


A regional hydrogeological study conducted by the Geological Survey of Canada acquired 35 line-km of 12-fold seismic reflection profiles on or adjacent to the Oak Ridges moraine, north of Toronto, Ontario, Canada. The three-dimensional geometry provided by these data aids in understanding the erosional and depositional processes that occurred beneath the Laurentide ice sheet during the late stages of glaciation. The seismic sections indicate large infilled channels in the subsurface which are interpreted as tunnel channels eroded by large, subglacial meltwater discharges. Two seismic profiles from different areas of the moraine show channel-cutting events of different ages and different types of infilling.


Objective To prospectively observe the effect of cystathionine βsynthase(CBS) T833C gene on the recurrence of ischemic vascular disease(cerebral infarction,TIA,myocardial infarction,other vascular embolism) in young and adult cerebral infarction.Methods The plasma total homocystine levels and CBS T833C genetypes of 152 young and adult cerebral infarction and 84 normal objects were respectively measured by high performance liquid chromatography methods and PCR-ARMS technologies,then we observed the recurrence of ischemic vascular disease within a 5-years follow-up period.Results The difference of recurrent cerebral infarction in CBS T833C C/C homozygous mutant,C/T heterozygous mutant and T/T wild type in patient group within follow-up period,the rate of recurrence was C/C genetype(35.00%) higher by turns than C/T(22.00%) and T/T(13.41%) genetype.The tendency was C/C genetype higher than C/T and T/T genetypes,C/T higher than T/T genetypes in different genetypes follow-up TIA,myocardial infarction and other vascular embolism.There was statistical significance of total ischemic vascular disease events in following up different genetypes(P 0.01),the rate of recurrence respectively were C/C genetype(60.00%),C/T genetype(40.00%) and T/T genetype(23.17%).By forward stepwise logistic analysis,we found that the increased tHcy level was a independent risk factor of recurrent ischemic vascular disease(OR = 1.110;95% CI:0.989 ~ 1.245,P 0.05),but CBS T833C gene mutation was not in the regression model.Conclusions The plasma tHcy level increase was a independent risk factor of recurrence ischemic vascular disease in young and adult cerebral infarction,CBS T833C gene mutation caused tHcy level rise and was probably susceptibility gene of recurrent ischemic vascular disease.


We present lessons learned from the construction of a telepresence platform for distance education. The platform main component is a full computer-assisted collaborative work tool for synchronous distance instruction that combines teleconferencing with a networked virtual environment. Our aim with the platform is to bring education to places with limited access to schools and colleges. In this paper we report results and lessons learned during the development and use of the platform in a simulated distance education setting for three actual courses taught at Eafit University.


Normal red blood cells, when transfused to patients with thalassemia, have been shown to have a normal life span (1-4). It has also been demonstrated that transfused erythrocytes from donors with thalassemia major rapidly disappear from the circulation of normal recipients (2, 4). This evidence supports the contention that the hemolytic component of the anemia in thalassemia is due to an intracorpuscular defect, as is the case in congenital spherocytic anemia (5) and in sickle cell anemia (6). We have had the opportunity to observe repeatedly approximately 20 children with thalassemia major during the past five years. All of these subjects have required blood transfusions to alleviate such recurring symptoms as listlessness, irritability, anorexia, fatigue, palpitations, weakness or dizziness. It was evident after review of the transfusion records that many of these children were receiving 500 cc. supplements of blood, or the equivalent in packed erythrocytes, at very short intervals, i.e., every ten days or every 25 days. Since (a) prior to transfusion, hemoglobin and hematocrit levels in any one patient were fairly constant (and definitely not rising over a period of several years), and since (b) there was no external loss of blood, it seemed logical to assume that the transfused blood was not surviving the expected


Objective:To explore the therapeutic effect of different methods for treating suprascapular nerve entrapment syndrome.Methods:Forty-one patients included 32 male and 9 female with the average age of 48 years ranging from 32 to 74 years;29 right,12 left;The course of disease from 2 months to 2.5 years,mean 9 months.Thirty patients were treated with local blocking;13 with small knife solution (included 7 failures with local blocking);8 with operative solution (included 3 failures with small knife).Patients of local blocking were injected with 1% Lidocaine and Triamcinodone Acetonide 40 mg once a week,2 to 4 times continuously.Patients of small knife were amputated in the superior or inferior transvers ligament of scapula,supraspinous and inferaspinous fossa were released.In operation of local anesthesia with direct vision,superior or inferior transverse ligament of scapula was amputated and suprascapular nerve was released.Results:All patients were followed up for from 3 months to 1 year.According to the therapeutic effective standard,in local blocking group,the result were cured in 2 cases,effective in 16,failure in 12;in small knife group,cured in 5,effective in 5,failure in 3;in operation group,cured in 6,effective in 2,no failure.Conclusion:Patients of short disease course and slight symptoms can select acceptable local blockade.It is necessary for patients with severe symptoms and medicine failure to use small knife releasing or operation releasing in direct vision,especially for those with myoatrophy.


Pulsed photoacoustic measurements have been carried out in liquid CS, using 532 nm radiation from A frequency doubled Nd:YAG laser. Variation of signal amplitude with laser fiuence clearly indicates the role of multiphoton processes in the generation of photoacoustic effect. It is also shown that four photon induced dissociation and live photon induced ioniZAtion are likely processes in CS, and 532 run radiation.


In this letter, we propose a dual-photodiode differential reshaping circuit that supports a wide bit rate range. The circuit, which offers a differential receiving function, can cancel out the influence of the leaked optical power and reshape input data within 1 bit regardless of the bit rate.


For $S \subseteq \mathbb{Z}^+$ and $k$ and $r$ fixed positive integers, denote by $f(S,k;r)$ the least positive integer $n$ (if it exists) such that within every $r$-coloring of $\{1,2,\dots,n\}$ there must be a monochromatic sequence $\{x_{1},x_{2},\dots,x_{k}\}$ with $x_{i}-x_{i-1} \in S$ for $2 \leq i \leq k$. We consider the existence of $f(S,k;r)$ for various choices of $S$, as well as upper and lower bounds on this function. In particular, we show that this function exists for all $k$ if $S$ is an odd translate of the set of primes and $r=2$.


We have studied the phosphorylation of the Bcl-2 family of proteins by different mitogen-activated protein (MAP) kinases. Purified Bcl-2 was found to be phosphorylated by the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) p54-SAPKβ, and this is specific insofar as the extracellular signal-regulated kinase 1 (ERK1) and p38/RK/CSBP (p38) catalyzed only weak modification. Bcl-2 undergoes similar phosphorylation in COS-7 when coexpressed together with p54-SAPKβ and the constitutive Rac1 mutant G12V. This is seen by both 32PO4labeling and the appearance of five discrete Bcl-2 bands with reduced gel mobility. As anticipated, both intracellular p54-SAPKβ activation and Bcl-2 phosphorylation are blocked by co-transfection with the MAP kinase specific phosphatase MKP3/PYST1. MAP kinase specificity is also seen in COS-7 cells as Bcl-2 undergoes only weak phosphorylation when co-expressed with enzymatically activated ERK1 or p38. Four critical residues undergoing phosphorylation in COS-7 cells were identified by expression of the quadruple Bcl-2 point mutant T56A,S70A,T74A,S87A. Sequencing phosphopeptides derived from tryptic digests of Bcl-2 indicates that purified GST-p54-SAPKβ phosphorylates identical sitesin vitro. This is the first report of Bcl-2 phosphorylation by the JNK/SAPK class of MAP kinases and could indicate a key modification allowing control of Bcl-2 function by cell surface receptors, Rho family GTPases, and/or cellular stresses.


Consideration is given to the analysis of the large-sample second-order properties of multiple signal classification (MUSIC) and subspace rotation (SUR) methods, such as ESPRIT, for sinusoidal frequency estimation. Explicit expressions for the covariance elements of the estimation errors associated with either method are derived. These expressions of covariances are then used to analyze and compare the statistical performances of the MUSIC and SUR estimation (SURE) methods. Both MUSIC and SURE are based on the eigendecomposition of a sample data covariance matrix. The expressions for the estimation error variances derived are used to study the dependence of MUSIC and SURE performances on the dimension of the data covariance matrix used. >


The epitaxial silicon growth temperature has been reduced to as low as 250 °C by optimizing the ion bombardment condition in low‐energy bias sputtering process. Independent and precise control of ion bombardment energy and ion flux density incident on a growing film surface is most essential to realize very low temperature epitaxy. It has been experimentally shown that the deficit in energy for epitaxial growth by reducing the substrate temperature is able to be compensated for by increasing the total energy dose on a film surface by low‐energy ion bombardment. Increase in the impact energy of individual ions, however, results in the formation of high‐density defects in the film. Therefore, the right direction to enhance the total energy deposition by ion bombardment is to increase the ion flux density while keeping the ion impact energy at an optimum value. As a result of such optimization, epitaxial growth of silicon has become possible at a temperature as low as 250 °C. The etch pit density in this low...


Aiming at clapper relay in the form of movable spring riveting with armature,the mechanical virtual prototype model of clapper relay was built by virtual prototype technology.By orthogonal experimental design method,the influence of the bending angle of movable spring to reaction force characteristics was analyzed to determine the key angles for normally closed contact force,final reaction force and revolution axis force.The validity of the model was verified by comparing with measuring results.This work can provide guidance in the process of reaction force system design and manufacture for this kind of relay.


Numerical calculations on the Jaynes-Cummings model in a cavity of arbitrary Q at finite temperature, using the master equation approach, are discussed. Effects due to mismatch of the atomic transition frequency and cavity mode frequency are included. Results relate to recent experiments on /sup 85/Rb Rydberg atoms. >


The Authors reflect on the relations between Italy and Brazil considering the study of Italian emigration, the preservation and protection of its linguistic and cultural traditions.