Anaplastic lymphoma kinase ( ALK ) rearrangements were first identified as an oncogenic driver in non-small cell lung cancers (NSCLC) in 2007, specifically the gene re-arrangement between ALK and echinoderm microtubule-associated protein like 4 ( EML4 ) (1).


Shearography has been shown to be a powerful tool for on- site non-destructive evaluation applications, especially in aircraft component inspections. However, current commercially available portable shearography systems are qualitative, low signal to noise ratio, and low flaw detection sensitivity. In this paper, we will introduce a real-time, high-resolution, portable, phase-stepping shearography system developed at the Applied Research Lab of The Pennsylvania State University. The system can fit into a wheeled cart and run at a speed of 1-2 inspections/sec for a 7 inch X 5 inch field of view. It provides full quantitative analysis ability and substantially improves flaw detection sensitivity. The applicability and portability of the system to on-site field NDE applications have been tested by a successful field demonstration conducted at a naval air station.


With the fast development of social economy,the highway construction expands to environment sensitive areas such as protected areas.Thereby it has great impacts on biodiversity conservation in protected areas.The paper mainly analyses the problems of highway construction related to protected areas,and brings forward six strategies which can coordinate the conflicts between protected areas and road construction.The strategies consist of regulation improvemeat,strengthening EIA,leading public participation,establishing the system of environmental impact post assessment and ecological compensation system,and enhancing personnel qualities.


AIM: To investigate the inhibitory effects of elemene on B-cell lymphoma cell line Raji in vitro and in vivo. METHODS: Raji cells were incubated with indicated concentrations of elemene.The growth of Raji cells were observed by CCK-8 colorimetric assay,apoptosis rates were detected by flow cytometry using Annexin V-FITC/PI staining,analysis of nuclear morphology were observed with DAPI staining,cell cycles were analyzed by PI staining.And its in vivo anti-tumor effect on transplanted Raji cells in SCID mice was detected as well.RESULTS:Raji cells viability in presence of elemene decreased markedly in a dose and time dependent manner.The apoptosis could be induced by elemene and its level increased following the augmentation of the drug concentration.The characteristic apoptosis nuclei were observed in DAPI staining after elemene treatment.A concentration dependent increase of cells in G0/G1 phase,a decrease in S phase and G2/M phase were detected.Elemene had a great ability to inhibit the growth of Raji cells in SCID mice.CONCLUSION: Elemene can significantly inhibit the growth of Raji cells,its function is performed by inducing apoptosis and arresting cell cycles in G0/G1 phase.


Starting in 2010, one of the most important policies for the introduction of Digital Technologies in schools, in modalities 1 to 1, has been implemented in Argentina: The "Programa Conectar Igualdad" (PCI, for its acronym in Spanish). This program proposed two complementary goals: one related to digital inclusion, which far exceeds school's ambit, and another one related to the improvement of education inside the school. The PCI consists not only of giving a netbook to students and teachers from every statal secondary school around the country — the more visible aspect of the program-, but also in the creation and availability of training courses for teachers, the appeareance of new actors — such as a technical referent of each school-, software and teaching contents for the educational community. This text presents a part of results of an investigation which analyzed in 2015 Argentina's secondary schools benefited of the PCI-on the basis of which the author wrote her doctoral thesis-, based on quantitative techniques of analysis of primary sources. A survey was applied to a representative and federal sample of 30 secondary schools throughout the national territory. In total, 3183 students and 342 teachers were surveyed. Here we focus on two central aspects of subjective dimension of school: frequency, type and space of usage of computers and netbooks, and skills with computers, according to students and teachers. We start from the assumption that these elements are heterogeneous depending on their socio-demographic and socio-economic characteristics.


Objective To observe the changes of animal activity scores and intercellular spaces of esophageal epithelial cells after esophageal balloon distention in rabbits,and to explore the possibility to prepare animal model of esophageal visceral sensitivity.Methods Twenty healthy New Zealand rabbits were randomly divided into three groups:group A(n=8),experimental group,inserting ERCP tubes with balloon(0.9 cm) into lower esophagus for fourteen days;group B(n=6),control group inserting the same ERCP tubes with no balloon into the lower esophagus for fourteen days;group C(n=6),control group with no insertion.The esophageal visceral senses were assessed by animal activity scores.Changes of intercellular spaces were measured by transmission electron microscopy.Results The animal activity scores of group A were significantly higher than those of groups B and C(P0.05).Compared with groups B and C,the diameters of esophageal epithelial intercellular spaces had no significant differences in group A.Conclusion Esophageal hypersensitivity may be induced by esophageal distention.


We attempt to determine the best order and search algorithm to store n comparable data items in an array, A, of length n so we can, for any query value, x, quickly find the smallest value in A that is greater than or equal to x. In particular, we consider the important case where there are many such queries to the same array, A, which resides entirely in RAM. In addition to the obvious sorted order/binary search combination we consider the Eytzinger breadth-first-search (BFS) layout normally used for heaps, an implicit B-tree layout that generalizes the Eytzinger layout, and the van Emde Boas layout commonly used in the cache-oblivious algorithms literature. After extensive testing and tuning on a wide variety of modern hardware, we arrive at the conclusion that, for small values of n, sorted order, combined with a good implementation of binary search, is best. For larger values of n, we arrive at the surprising conclusion that the Eytzinger layout is usually the fastest. The latter conclusion is unexpected and goes counter to earlier experimental work by Brodal, Fagerberg, and Jacob (SODA 2003), who concluded that both the B-tree and van Emde Boas layouts were faster than the Eytzinger layout for large values of n. Our fastest C++ implementations, when compiled, use conditional moves to avoid branch mispredictions and prefetching to reduce cache latency.


In this paper a wireless infrared motion tracking system created in the Fraunhofer Institute for Media Communication is described. The system is able to track stylus and head of a user simultaneously and in real time. Infrared beacons are used to allow the system to operate together with projectors without their influence. The principles of the calibration process, distortion correction and reconstruction are described. The characteristics of the tracking system are given with regard to the hardware configuration needed.


The finite element analysis of unstiffened steel plate shear walls (SPSWs) has been implemented to date with only limited success. Because of local instabilities and snap-through buckling of infill plates, commonly used solution techniques fail to converge to the equilibrium path as cyclic buckling takes place in the plate. Lack of convergence is a major problem in finite element analysis of these systems especially when geometric nonlinearities are included in the model [1, 2].


The paper applies battery energy storage system (BESS) to enhance transient stability response of an island micro-grid with high renewable energy penetration. At first, the grid data including the network topology, the system load profile, wind generators (WGs), photovoltaic generation (PVG) and the operation strategy with unit commitment of the diesel generators are collected. Then the mathematical models of the governor and exciter of the diesel generators is confirmed and derived. Also, the relationship between the wind speed and the WG power output, and the solar irradiance and the PVG power output are derived in detail. After that, transient stability analysis is investigated for various contingency scenarios such as tripping of wind generators or ramping change of PVG power output. To enhance the system reliability, the battery energy storage system (BESS) is applied to improve the system frequency response to prevent the execution of load shedding.


Buddhist communication styles for new generation in present-day Thailand were an interdisciplinary study which concentrated on quantitative research. The study was conducted by survey research using 440 self-administered questionnaires as a tool to collect data. In-depth interview and focus group discussion which were qualitative research methods were also used to acquire supported data in order to make the research become more complete. The three objectives of this study were 1) To analyze media exposure behavior of new generations 2) To study Buddhist communication styles for new generations in present-day Thailand 3) To present policy suggestion resulting in guideline to establish appropriate Buddhist communication styles for a new generation in Thailand. The statistics used in the study were percentage, mean, independent t-test, f-test (One-Way Analysis of Variance), and Pearson's Product Moment Correlation Coefficient.The findings regarding Buddhist media-exposure behavior of the new generations showed that mobile phone was the most often used electronic device to communicate through online social media using wireless network connection. The frequency of Buddhist media exposure among most of the subjects was low with mostly once every two weeks. The Buddhist media exposure was unintentionally. The period of time for Buddhist media exposure via online social media was frequently during 18.01-21.00. Buddhist media exposure mostly occurred on Sunday. Most of the subjects took less than 30 minutes at a time for Buddhist media exposure via online social media. Buddhist media exposure through online social media mostly happened at their residence. Communication services/programs through online social media which were mostly used for Buddhist media exposure were Facebook, Youtube, and Instagram respectively. Regarding companions during Buddhist media exposure, the subjects were often alone.The overview of Buddhist communication to a new generations showed that Facebook should be used as an online communication channel and presented with videos using communication through website in form of One-to-Many asynchronous communication. The content needed was Buddhist information which basically used informal language for communication.Besides, the results of this study pointed that the subjects paid attention to Buddhist information according to the individual person they attached to. The presentation format had to be interesting and suitable for the target group. Arrangement of difficult content should be simplified. Religious issues should be carefully selected to meet the needs and ways of life. Online communication could be achieved through working as a group.The findings from this study also indicated some policy suggestions resulting in guideline to create appropriate Buddhist communication styles for new generations in present-day Thailand which was divided into 2 phases. The first phase was short-term or urgent that included 1. To promote online media to disseminate religious information of monks, Buddhist agencies and organizations which were already recognized 2. To increase the frequency and amount of Buddhist communication 3.To use online media communication that could reach the target group by adopting the results of this research as communication guideline and 4. To study the pattern of Buddhist communication model from Phra Maha Wuttichai Vajiramedhi and Phra Maha Sompong Talaputto.The second phase to create an appropriate pattern of Buddhist communication was long-term which included; 1. To compliment Buddhist personnel and organizations promoting their value and making them widely recognized; 2. To develop the human resources by providing them with technological knowledge; 3. To promote knowledge of integrated communication and increase proactive public relations via integrated online communication; 4. To produce new Buddhist communicators to the society; 5. The online media access gap between urban and rural youth should be reduced; 6. To continually cultivate Buddhist information to Thai youth since they were young; 7. To encourage previous generation to express solid interest in Buddhism in order to create good role modelHypothesis testing showed that the subjects with different ages and education would have different media exposure behavior. Ages, education, and different regions were factors affecting satisfaction toward pattern of Buddhist communication via online social media. Ages, education, and different regions had influence on desire for Buddhist communication styles via online social media.Cost, duration, and frequency of online media communication were key factors relating to satisfaction toward pattern of Buddhist communication styles via online media that currently obtained. Cost, duration, and frequency of media communication were key factors relevant to desire for pattern of Buddhist communication via online social media.


A system has been developed for trucking gas production from marginal or isolated wells which have insufficient reserves to justify construction of a pipeline connection. System operation, equipment requirements, and pertinent cost factors that determine whether truck transport can be used to economically produce a well are discussed.


Background: Nonalcoholic fatty liver disease (NAFLD) is emerging one of the major causes of chronic liver damage that includes a wide spectrum of liver injury ranging from steatosis to steatohepatitis evolving to fibrosis.
Aim: This study was designed to evaluate the possible effect of EUG on NAFLD induced by high fat cholesterol diet.
Methods:Rats were fed either normal rat chow diet (control) or high fat cholesterol diet and both received olive oil (10 mg/kg) for eight weeks to induce NAFLD model. Eugenol (10 mg/kg) was administrated to rats by oral intubation 3 times weekly for 8 weeks.
Results:Our results showed that EUG significantly ameliorated the histopathological lesions induced by HFCD. Furthermore, HFCD induced a significant elevation in liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)). This was significantly attenuated by EUG co-treatment.
Conclusion:These findings indicate that EUG possess es  a marked role in modulation of NAFLD.


The film provides a basic introduction to types of woman seafarers already familiar to maritime historians the cross-dressing women who went to sea, female pirates, captain's wives and stewardesses. The film makers correctly point out that women's maritime careers were segregated into service jobs on passenger liners shortly after the first passenger liner crossed the Atlantic in 1838. Even today, most women on large passenger liners work in catering departments, though career progress has become much better, and the film introduces a chief steward who, a hundred years ago, could have never been a woman, at least not on a passenger liner. Nevertheless, while the film manages through interviews with contemporary seafarers to cover the most difficult issues that face woman seafarers, historians will find that the film offers only thin coverage on the history of seafaring women, despite the fact that many contemporary issues for women at sea have historic roots. Most interviewees claim that men onboard ships have demanded that women hide their femininity. Women are expected or forced to be masculine in order to survive. If they do not, they suffer sexual harassment and hostility. The interviewees expose severe sexual stalking and verbal abuse. One of the interviewees observes that sexual harassment is in fact based on fear because men are afraid of women and aim to control them through harassment. As one of the women claims, seafaring is not a job for weak women or for weak men. This DVD is political and thought-provoking. It has a clear agenda: to show that sexual harassment and occupational segregation, as well as gender discrimination, are still very much a reality in seafaring. These women have to deal with prejudiced working communities in isolated spaces and therefore have to prove themselves much more than men. Despite the fact that women have always been at sea, the segregation remains rigid. Most women still work in jobs which do not have much authority, at least not over men. Despite the shortage of women in top-level maritime jobs, the film concentrates on them, perhaps in order to empower women. Shipping Out shows that contemporary seafaring has very few jobs that require extreme physical strength and that therefore most jobs are perfectly suitable for women.


HOUGH Yeats wrote "In memory of Major Robert Gregory" at a time when he was fully absorbed in the complicated theories later to make A vision, the elegy is simple and exoteric, traditional, yet entirely modern. So instantly palpable a poem seems to demand no exegesis; but the process by which it came into being and the elements united in it are extremely complex. In this poem Yeats first used the tower of Ballylee as a personal symbol. In it also he developed his concept of the possible fusion of the artist and the man of action into a unity of being. Here, too,>Yeats concentrated much of his thinking and feeling about the arts, especially painting and poetry, and remarkably synthesized the views of two nineteenth-century English painters he had long admired. None of Yeats's poems succeeds better than this elegy in putting the personal into a static form, a process which he compared to "the metaphysical antinomy of the individual and the infinite, the many and the one."2 When Major Robert Gregory was killed leading his air squadron on January 23, 1918, Yeats was moved to write at once of the son of his old and dear friend. His note of appreciation was printed in the Observer, February 17, 1918, and reprinted in America in the Little review in November of the same year. This almost unknown tribute, later to be concentrated into the praise of Gregory in the last six stanzas of the elegy, shows Yeats in his frequent habit of writing first in prose and then transmuting his concept into poetry. The opening of the eulogy cites Gregory's many gifts, "painter, classical scholar, scholar in painting and in modern literature, boxer, horseman, airman"-a variety so great that, Yeats said, "his very accomplishment hid from many his genius." To Yeats, Gregory was "a great painter in the immaturity of his youth," a genius the poet had first recognized in the young man's designs of costumes and scenery for the Abbey Theatre, "decorations which, obtaining their effect from the fewest possible lines and colours, had always the grave distinction of his own imagination." Gregory's paintings long perplexed Yeats by what seemed neglect of detail. "But," he wrote, "in a few years I came to care for his paintings of the Clare coast, with his cloud shadows upon blue-grey stony hills, . . more than for any contemporary landscape painting." This admiration for Gregory's painting persisted, and in Yeats's home in his last years space was made between the books in his study for one of Gregory's landscapes. The climax of the tribute to the painter's art follows:


The present invention relates to volatile material-containing composition is a constant release profile, which carrier, preferably comprises at least one polymer of polyethylene glycol is less than, greater than at least two components and a hydrophobic volatiles index is 1.0 3.0. Volatile material, the carrier, a polymer, a hydrophobic composition, release profile


Due to the random and complex geometrical shapes, most of the work on open-cell solid foams are experimental, and only a limited number of numerical studies are available in the literature. In the present contribution a sharp Immersed Boundary Method (IBM) is developed to fully resolve the random structure of the solid foam on a non-body fitted Cartesian computational grid. 3D image data from a Micro-CT (computed tomography) scan of an actual foam geometry is converted into unstructured triangular elements (surface mesh) and incorporated as immersed surface in the present sharp interface method. The novel feature of the fluid–solid coupling technique is the direct (i.e. implicit) incorporation of the no-slip boundary condition (with a second-order method) on the surface of the particles at the level of the discrete momentum equations. The use of a Cartesian grid for flow makes this method robust and computationally friendly. At the same time it avoids the tedious volumetric mesh generation process for very complex shapes. After presenting some verification cases, we perform simulation results for flow through a section of a typical random foam structure generated from a CT-scan technique. The Reynolds number is varied from creeping flow to Re ~ 40. Finally, a pressure drop correlation is proposed for this particular foam sample.


The paper discusses the aspects of claiming by tax authorities in the framework of criminal proceedings. Legal regulations of current Russian legislation are studied. The law-enforcement practice is analyzed, therein: the practice of tax and law enforcement agencies, courts of arbitration and courts of General jurisdiction. It is noted that Russian legislation provides a tax authority with the right to participate in criminal proceedings as a civil claimant. It is also noted that this right is primarily intended to eliminate damage caused to budget system, through commencement of civil action (complaint). Damage caused by crime to the state should primarily be compensated within the criminal procedure. The author presents some practical materials from which it follows that there is no uniform approach to the question of resolving the lawsuit within the criminal procedure. The outlined circumstances actualize questions regarding compensation of budget system damage within the criminal process.


The International Conference on the Voyn-ich Manuscript, which took place 30 November and 1 December 2022, was the first peer-reviewed conference that was dedicated entirely to the Voynich MS. The only similar event took place ten years earlier at Villa Mondragone, Fras-cati, Italy, with invited presentations but without published proceedings (Schmeh, 2013). This paper summarises the event, its preparation and organisation, with a summary of the papers that were presented and potential avenues for further research.


The present invention provides an aqueous cosmetic, aqueous cosmetic comprising the: (A) containing a ceramide and as an oil phase is dispersed in the aqueous phase particles containing ceramides, (B) fatty acids and fatty acid salts of at least one fatty acid component, and (C) contains IOB of 2.2 or more and the total content in the composition is less than 3 mass%, 20 mass% of the first polyol and IOB of 2.0 or less and the total in the composition 0 or the content of the polyol component is 3 mass% or less of the second polyol, and the total content of the surfactant in the composition is 0 or 1 mass% or less, of the total mass of the ceramide in the compositions not less than 3.0 times the mass of said total fatty acid composition.


The derivation of quality control data from patient laboratory values presupposes, first, that the distribution of those values is stable over long periods of time; second, that it is possible to estimate accurately the mean of the entire population from a small sample of that population. That the first presupposition is true for erythrocyte indices has been shown elsewhere. The second presupposition is examined in this paper. Six estimators were tried in turn on two data batches, each consisting of 480 patients from two university hospitals. An estimator which smoothed the data (decreased the effect of oudying values) and at the same time showed the characteristics of a moving average was found sufficiently effective to serve as the major basis for quality control of an automated whole blood analyzer.


This study investigates the maximum heat flux and its corresponding superheat temperature for a straight pin fin in a boiling FC-72. Investigations are carried out numerically under atmospheric pressure by solving a three dimensional heat conduction equation in steady state. The finite element method (FEM) is used to investigate this phenomenon. The numerical results are in good agreement with available experimental results. One-dimensional analysis of boiling on a straight pin fin had been carried out. Therefore, comparison is made between the one and three-dimensional analysis results. The effect of length and diameter on the maximum heat flux (MHF) and the operational stability are also investigated.


Liquefaction of saturated loose sands during an earthquake has been a great concern for practicing earthquake engineer because of its damaging effects. Current liquefaction mitigation techniques used in practice are expensive. A new innovative mitigation technique which is cost effective was proposed by Yegian et al. [1] called "Induced Partial Saturation" (IPS). This method involves in generating gas bubbles within the pores of fully-saturated sand and transformed it to partially-saturated sand. This paper described the development of a dynamic impact cone to assess the effect of this IPS treatment on saturated loose sand specimens. This dynamic impact cone consists of a cone, rod, ruggedized pressure transducer, string pot, and DAQ. The cone which has pressure transducer incorporated at its tip was driven into fully and partially (treated) saturated sand specimens prepared in the laboratory. The excess pore pressures and penetrations depth per impact of the two specimens were compared. The tests results such as the excess pore pressure and the penetration indicate that the impact penetration on the fully-saturated specimens liquefied sand, but could not liquefy the partially-saturated sand. Therefore the concept and development of this dynamic impact cone has promising future applications.


Objective To investigate the correlation between sperm DNA integrity and semen parameters,to explore the value of DNA integrity detection in evaluation of male fertility. Methods Routine semen analysis of 206 male sterile patients were examined,and sperm DNA integrity were detected by sperm chromatin dispersion( SCD) to calculate DNA fragmentation index( DFI). The relationship between DFI and sperm concentration,motility,and morphology were analyzed. Results Significant differences were found in abstinence duration,rate of sperm motility,D grade sperm,head defect,neck defect and sperm survival rate among the three groups classified as DFI≤10%,10% DFI≤30% and DFI 30%. The correlative analysis showed DFI was positive correlation to D grade sperm,head defect,neck defect,sperm deformity index( SDI) and teratozoospermia index( TZI),while negative correlation to rate of sperm motility,normal morphology,sperm density and sperm survival rate. Conclusion Sperm DNA damage might lead to abnormal sperm morphology and decrease of motility. The routine semen analysis combine with detection of sperm DNA integrity may improve the assessment of male fertility.


Objective To Determination the content of phenols in samples of Magnoliae Cortex,which are originated in Shennongjia and Enshi of Hubei province,and to compare with the other commodities of different areas.Methods The HPLC method was performed on Agilent HC-C18(4.6×250mm×5μm),with a wavelength of 294nm and methanol-water(78:22) as the mobile phase.Results The comparisons on the contents were as follows: Enshi trunk bark 19.103%Enshi branch bark 4.744% shennongjia trunk bark 3.666%Guangdong sample 3.107% Guangzhou sample 2.929%Hubei Tianji sample 2.485%Beijing sample 1.707% shennongjia branch bark 1.500% Senzhen sample 0.826% Hubei Derentang sample 0.040% Hongkong sample 0.016%Conclusion The Manoliae Cortex of Hubei Enshi has the best quality,followed by Shennongjia sample,Guangdong sample,Hubei Tianji sample and Guangzhou sample.Above a few varieties can meet the requirements of Pharmacopoeia(≥2%),the other 5 samples are below the standard of Pharmacopoeia.


Poly(dimethylsiloxane)s (PDMS) of different crosslinking degrees were synthesized by varying the ratio of B(crosslinker)/A(vinyl-type PDMS) in the mixture to be crosslinked, and by varying the crosslinking temperature. The swelling degrees of the polymer in pure water, pure ester (ethyl acetate) and their mixture decrease when the B/A component ratio or the crosslinking temperature increases. The ester component is selectively sorbed from its mixture with water (the sorption extent is two orders of magnitude higher for the ester than for water). The sorption selectivity increases with the B/A component ratio and the crosslinking temperature. We attributed these changes in properties to a change in the degree of crosslinking in the network, which increases with the B/A component ratio or the crosslinking temperature. The ester sorption in PDMS from the water–ester mixture (ternary system) can be correctly described by the Flory model for the pseudo-binary mixture (ester–PDMS). The value of the Flory interaction parameter increases with the B/A component ratio. The water sorption from water–ester mixtures cannot be described using the same approach.


Abstract This paper fast proposes a novel lossless data-hiding method, in which the magnitudes of gray level differences in pixel pairs are slightly increased so that the region of differences with small magnitudes can be used to carry the hidden message. Overflow is avoided by prohibiting modifications to certain pixel pairs, and a small number of labels marking these exceptions are also embedded for perfect recovery of the host. Since this method avoids embedding any compressed data of location map or original data, the payload-distortion performance is very high. The lossless data-hiding method is then applied to implement a reversible visible watermarking scheme. After semi-transparently embedding a binary watermark image, some additional data about the mark and the host image are also inserted in the lossless manner. When the visible watermark is extracted from the marked version, the original host image can be completely restored without any error.


Interaction of electromagnetic fields with elastic bodies is the subject of many theoretical investigations in mechanics of continua for the last decades. Some variants of direct and inverse problems have been studied leading into the determination of some characteristics of a medium. It is very interesting to study this phenomenon due to the possibility of applying this theory to geophysical prospecting and study of earthquake sources. It is well known that when an electrical-conducting elastic body oscillates in an electromagnetic field, variations of the electrical and magnetic fields are observed as a result of this motion. Similar processes are also observed when seismic waves propagate in the Earth's crust. Variations of the seismic and electromagnetic fields arising in this case are called electromagnetoelastic waves . Our work is dedicated to investigation of such interaction. The model considered here is based on a simple variant of combination of the Lamé and Maxwell equations. We form the basic equations for the description of some variant of this coupling and consider mathematical and numerical models of this process.


Abstract 3926

Introduction. Chronic lymphocytic leukemia (CLL) patients will have significant variation in signs and symptoms at initial presentation and across lines of therapy, with concomitant effect on patient health-related quality of life (HRQOL). HRQOL and other patient-reported outcomes, together with clinical outcomes, provide a more complete perspective on the burden of disease and facilitate a broader view of the impact of treatment regimens. This analysis evaluates whether the HRQOL of patients with CLL in the United States (US) varies at the time the patients are about to embark on various lines of therapy, and offers a baseline report from which subsequent longitudinal analysis post-treatment will be possible.

Methods. Clinical and HRQOL data were collected in Connect®CLL, a prospective observational registry initiated in March 2010 involving centers in the US. Physicians provided data on the demographics and clinical characteristics of patients receiving therapy. HRQOL was self-reported by patients at enrollment using the Brief Fatigue Inventory (BFI, a symptom assessment tool), the EQ-5D (a non-disease-specific HRQOL instrument), and the Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu, a leukemia-specific HRQOL instrument). We characterized patients who had initial (First Line), second (Second Line) or subsequent (Higher Line) treatment regimens prior to initiation of regimens. Reported mean overall and/or domain-specific BFI, EQ-5D and FACT-Leu scores were analyzed by line of therapy. Statistical significance of score differences among sub-cohorts was ascertained by ANOVA using SAS 9.1.

Results. Evaluable data were reported on 1005 patients, enrolled from 161 centers (93% community, 7% academic). Patients were predominantly male (62%) and white (89%) with mean age at 69 (standard deviation [SD] 11) years. HRQOL scores by line of therapy are presented:

| HRQOL Scores | First line (n=633) | Second line (n=197) | Higher line (n=175) | P-value |
|:-----------------------------:| ------------------ | ------------------- | ------------------- | ------------ |
| BFI Mean (SD) | | | | |
|     Global | 4.1 (2.4) | 4.3 (2.4) | 4.2 (2.4) | 0.0423[*][1] |
|     Severity | 4.9 (2.7) | 5.1 (2.8) | 4.9 (2.5) | 0.0181[*][1] |
|     Interference | 3.7 (2.5) | 3.9 (2.5) | 3.9 (2.6) | 0.1007 |
| EQ-5D, mean (SD) | | | | |
|     Index overall | 0.87 (0.14) | 0.84 (0.15) | 0.83 (0.15) | 0.0195[*][1] |
|     VAS overall | 73.8 (19.6) | 70.7 (19.9) | 69.8 (18.5) | 0.0232[*][1] |
|     Mobility domain | 1.2 (0.4) | 1.3 (0.5) | 1.3 (0.5) | 0.0091[*][1] |
|     Self Care domain | 1.0 (0.2) | 1.1 (0.3) | 1.1 (0.2) | 0.1453 |
|     Usual Activities domain | 1.4 (0.5) | 1.5 (0.6) | 1.4 (0.6) | 0.1280 |
|     Pain/Discomfort domain | 1.4 (0.5) | 1.5 (0.6) | 1.5 (0.5) | 0.0049[*][1] |
|     Anxiety/Depression domain | 1.3 (0.5) | 1.3 (0.5) | 1.4 (0.5) | 0.7132 |
| FACT-LEU Mean(SD) | | | | |
|     Physical | 22.9 (4.4) | 22.2 (4.9) | 22.0 (5.3) | 0.0129[*][1] |
|     Social/Family | 23.8 (4.8) | 23.6 (5.1) | 22.6 (5.8) | 0.0819 |
|     Emotional | 19.2 (3.7) | 19.5 (3.6) | 18.7 (3.9) | 0.1820 |
|     Functional | 19.9 (5.9) | 19.5 (6.0) | 19.1 (6.6) | 0.4145 |
|     Leukemia subscale | 50.2 (9.6) | 48.9 (10.9) | 47.3 (11.1) | 0.0023[*][1] |
|     FACT-G Total | 85.8 (13.9) | 84.6 (14.1) | 82.5 (15.9) | 0.0372[*][1] |
|     FACT-LEU Total | 136.3 (21.7) | 133.4 (22.7) | 129.8 (25.1) | 0.0039[*][1] |

* P-value from ANOVA among three groups.

* [↵][2]* Statistically significant at 0.05.

The total FACT-Leu and FACT-G results, and the total EQ-5D Index and Visual Analogue Scale (VAS) results, consistently suggest that patients initiating first line therapy have somewhat better HRQOL compared with those initiating subsequent lines of therapy. FACT-Leu total scores of patients initiating first line therapy were associated with better physical and leukemia-specific considerations, and the EQ-5D total score was associated with better mobility and pain/discomfort.

Conclusions. Initial results from the Connect® CLL Registry indicate that HRQOL prior to treatment is better among patients initiating first line therapy compared to patients initiating later lines of treatment. Future analyses should be conducted to determine what clinical or other factors may be associated with the HRQOL deterioration in patients initiating subsequent lines of therapy, so as to inform clinician decision making. Also, subsequent longitudinal analyses should be undertaken to determine how HRQOL might be affected by the different lines of therapy and the specific treatment regimens, as well as by their initial HRQOL and other patient factors.

Disclosures: Kay: Celgene: Research Funding. Flowers: Celgene: Consultancy; Prescription Solutions: Consultancy; Seattle Genetics: Consultancy; Millennium: Research Funding, Unpaid consultancy, Unpaid consultancy Other; Genentech: Unpaid consultancy, Unpaid consultancy Other; Gilead: Research Funding; Spectrum: Research Funding; Janssen lymphoma research foundation: Membership on an entity's Board of Directors or advisory committees. Weiss: Celgene: Consultancy. Lamanna: Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding. Flinn: Celgene: Research Funding. Grinblatt: Celgene: Honoraria, Speakers Bureau. Kipps: Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding. Kozloff: Celgene: Consultancy. Lerner: Celgene Connect: Membership on an entity's Board of Directors or advisory committees. Sharman: Celgene: Consultancy; Pharmacyclics: Honoraria; Calistoga: Honoraria; Portola pharmaceuticals: Consultancy. Khan: Celgene Corporation: Employment, Equity Ownership. Street: Celgene: Employment, Equity Ownership. Swern: Celgene: Employment. Sullivan: Celgene: Employment. Pashos: Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding.

 [1]: #fn-2
 [2]: #xref-fn-2-1


An improved bounded real criterion is derived by employing a descriptor system approach. When used in robust performance analysis of systems with convex polytopic type uncertainty, it can reduce conservatism inherent in the classical quadratic method by providing a parameter-dependent Lyapunov function. Compared with the existing similar results, our approach shows some favorable features in computation. Two numerical examples are included to illustrate the effectiveness of the proposed representations.


In this case scenario, the reader has the the opportunity to diagnose the patient described in the title, on the basis of the history, examination results, laboratory evaluations, and neurophysiologic and imaging findings. The diagnosis and a discussion of the case are presented on pages 195-197.


Patulin is a mycotoxin specially produced by Aspergillus clavatus and can contaminate several beans, like peanuts, soy beans and papper, especially the damage one with nephrotoxic as well as hepatoxic effects. This experimental study was conducted in order to know the effect of patulin in different doses towards the mice hepatocyte structural and untrastructural damage by using male and tree months age of BALB-C mice (Mus musculus). They were devided into 4 groups which were orally administered with patulin in three different doses. Those were 1mg/kg BW, 1,75mg/kg BW, and 2,5mg/kg BW respectively. Structural damage of hepatocytes on centrilobular, midzonal, and peripheral zones ware observed and examined histopathologically and the ultra structural damage ware examined using Transmission Electron Microscope (TEM). Results of this study showed that: 1) there was an effect of patulin to mice hepatocyte structure damaged as well as ultra structure damaged; 2) there was a difference effect of some dose of patulin on the value of mice hepatocyte structure damage. The level of mice hepatocyte structure damage was riced as well as the increase of patulin doses; 3) dose-3 (2,5mg/kg BW) is the highest dose which cause the highest structural mice hepatocyte damage; 4) there was different effect of patulin to mice hepatocyte structure damage on the three zones of hepar lobulus; 5) the perifer zone was the highest damaged area of the three hepar lobulus zones.


A study of parasitic monogenea of three exotic fish species Pangasius hypophthalmus, Cyprinus carpio and Hypophthalmichtys molitrLt from different waterbodies of Mymensingh, Bangladesh, were made. Five species of monogenetic trematodes belonging to 4 different genera Dactvlogyrus, Silurodiscoides, Bffitrcohaptor and GyrodClc~vlus were collected and identified. They are Silurodiscoides siamensis from Pangasius hypophthalmus, B{fitrcohaptor indiclts form Pangasius hypophthalmus, Dac~vlogyrus minutes from Cyprinlfs carpio, Dactylogyrus hypophthalmichthys from Hypophtha/michthys mo/itrix and Gyrodactylus sp. from Cyprinus CQfpio. These parasites are recorded from the gills. The descriptions of these species with their taxonomic characters have been made.


This research was to analyze essential oils from the species of plants from the Rutaceae family using expression method. Yield of essential oil from Citrus nobilis was 1.44%,
1.29% from Citrus limon and 1.64% from Citrus microcarpa. The compounds were analyzed by a combination of gas chromatography and mass-spectrometry techniques (GC-MS). There were 12, 10 and 11 compounds respectively present in Citrus nobilis, Citrus limon and Citrus microcarpa. D-limonene was the major compound in all samples which were 80.42% in Citrus nobilis oil, 65.62% in Citrus limon oil, and 52.56% in Citrus microcarpa oil


This paper deals with the nature or the ontological status of social entities. Traditional critiques to Durkheimian sociology, for instance, raise the question about the reification of the social. The autonomy of social realities and their irreducibility to psychical and physical realities is the focus of my discussion. If human beings were suppressed, social realities would cease to exist, but this doesn't imply that social events depend solely upon psychic variables. I try to argue for the thesis of the autonomy of the social and its downward determination upon the behavior of human individuals. In order to do this I introduce the notions of linguistic space and cultural space, which are in themselves abstract realities and enable us to analyze the social origin of our concepts and values. I argue that cultural objects are real perspectively, i.e. they exist just from the human point of view, but they are objective realities nonetheless, since they aren't eliminable, or reducible, and in addition they have normative power over the behavior of individuals.


This article discusses the use of the Many-Facets Rasch Model, via the FACETS computer program (Linacre, 2006a), to scale job/practice analysis survey data as well as to combine multiple rating scales into single composite weights representing the tasks' relative importance. Results from the Many-Facets Rasch Model are compared with those calculated from the Rasch Rating Scale Model (RRSM) (Spray & Huang, 2000) using two examples of actual job analysis data from diverse professions. In addition, this article proposes a solution for establishing the origin of the percentage scale when transferring the task importance weights from a logit unit into percentage weights. Although the resulting test specifications from the two compared methods are not radically different, a case is made that the use of the Many-Facets Rasch Model with a zero point based on the frequency rating scale provides a more justifiable basis for combining multiple rating scales and transforming task survey data. In addition, this study found that the Many-Facets Rasch Rating Model can better accommodate missing data than the RRSM method in situations in which respondents only rate subsets of the multiple scales and not all of the scales for the tasks being surveyed.


In cold and humid climates, warming temperatures will result in longer growing seasons, leading to land cover changes that could have long‐term impacts on groundwater recharge (GWR), in addition to the direct impacts of climate change. The objective of this study was therefore to investigate whether land cover (LC) changes need to be considered when simulating long‐term regional‐scale potential GWR in cold and humid climates by (1) quantifying how LC changes impact simulated GWR and (2) quantifying the combined impacts of LC and climate changes on the future GWR changes. Using the region of southern Quebec (Canada) as a case study and a water budget model, this work proposes an innovative coupling of land cover change scenarios and specific future climate conditions to simulate spatially distributed transient GWR over the 1951–2100 period. The results showed that including LC changes in long‐term GWR simulations produced statistically significant increases in GWR compared to using a constant LC through time (average of +13 mm). Massive afforestation taking place on agricultural lands simulated for one of the scenario chains (RCP4.5) increased GWR by reducing runoff during the snow‐dominated period (average − 17 mm). The results also showed that GWR was more sensitive to climate change for scenarios that included intense land cover changes. Additionally, the spatial distribution of the LC changes influenced their simulated impacts on GWR. Considering that the methodology was computationally feasible and entirely transferrable to the new CMIP6 ensemble, LC changes should be considered systematically in long‐term groundwater resources simulations.


The design of noise barrier should be combined with the design of acoustics,structure and landscape. As people improve their environmental requirements,they not only pay attention on the noise reduction effect but also on the landscape of noise barrier. The design of the noise barrier landscape will be raised to be equally with the design of acoustics and structure,and will be taken as and important part of the whole design of noise barrier,therefore the design of the noise barrier landscape will be the future development trend of the noise barrier design. This essay gives analysis on the current status of railway noise barrier,and some considerations on the design of railway noise barrier landscape from four aspects of the landscape design principle,exterior design,choices of the materials and color.


Background: Ethnic differences in being overweight and obesity were studied among 18 year old males in Sweden. Methods. This nationwide study was based on a record linkage between the Medical Birth Register, the Register of Military Induction Examinations and the Register of the Total Population. For 140,766 (87.8%) of the 160,247 males information was available on body mass index (BMI) and on their mothers' nationality. Results. After adjustment for education and geographical region the odds ratio for being overweight was found to be higher among 18 year old sons of immigrants from Finland (1.38 and 95% Cl: 1.26–1.52) than among sons of Swedish mothers. Similarly, the odds ratio for being overweight was higher among the sons of immigrants from former Eastern Europe (1.68 and 96% Cl: 1.46–1.94) than among sons of Swedish mothers. Conclusions: The risks of being overweight and obesity were increased among the sons of immigrants from Finland and former Eastern Europe compared to sons of Swedish mothers.


With the deepening construction of campus information, more and more application systems run in campus network. These systems need more servers, more room and more power, which make the operational maintenance cost increase and efficiency decline continually. This paper analyzes some problems about construction of campus data center based infrastructure and propose a solution using virtualization technology in centralized management of hardware, data, and application service.


The biofouling of surfaces submerged in the marine environment includes primary colonization of the substrate by microorganisms including bacteria, microalgae, and microscopic reproductive propagules of macroorganisms such as algal zoospores. The present study reports the evaluation of the inhibitory potential of biofilms and extracellular products (EP) of the indigenous bacterium Alteromonas sp strain Ni1-LEM on the settlement of marine biofouling such as: (i) eight marine benthic diatoms and (ii) zoospores of the alga Ulva lactuca , as well as the germination of these zoospores and was compared with reference strains with proven antifouling properties, Halomonas marina (ATCC 25374) and Pseudoalteromonas tunicata . Highest antifouling activity was found for the indigenous strain. In attempts to better define the chemical nature of the antifouling substance in the EP of the Alteromonas sp strain Ni1-LEM, the culture filtrates were tested for activity after heat treatment, enzymatic treatments, dialysis through semipermeable membranes, and separation into polar (aqueous) and non-polar (organic) fractions. The results suggested that the antifouling substance in the culture filtrates to be protein or peptide in nature, thermostable, hydrophilic, and equal to or greater than 3500 daltons in molecular size. Antifouling substances from bacteria may lead to the development of novel antifouling agents in the future.


Residual stresses, existed in engineering structures, could significantly influence the mechanical properties of structures. Accurate and non-destructive evaluation of the non-equibiaxial residual stresses in these structures is of great value for predicting their mechanical performance. In this work, investigating the mechanical behaviors of instrumented spherical indentation on stressed samples revealed that non-equibiaxial residual stresses could shift the load-depth curve upwards or downwards and cause the residual indentation imprint to be an elliptical one. Through theoretical, experimental, and finite element (FE) analyses, two characteristic indentation parameters, i.e., the relative change in loading curvature and the asymmetry factor of the residual indentation imprint, were found to have optimal sensitivity to residual stresses at a depth of 0.01R (R is the radius of spherical indenter). With the aid of dimensional analysis and FE simulations, non-equibiaxial residual stresses were quantitatively correlated with these two characteristic indentation parameters. The spherical indentation method was then proposed to evaluate non-equibiaxial residual stress based on these two correlations. Applications were illustrated on metallic samples (AA 7075-T6 and AA 2014-T6) with various introduced stresses. Both the numerical and experimental verifications demonstrated that the proposed method could evaluate non-equibiaxial surface residual stresses with reasonable accuracy.


Abstract : From May 1974 through June 1975, the approach region to runway 28R at Heathrow International Airport was equipped with aircraft wake vortex tracking equipment. The vortices from approximately 13,000 aircraft were monitored along with the attendant meteorological conditions. The joint US/UK project represents a major step in learning how vortices move and die in the terminal environment. Volume II describes the entire project from the workings and locations of the equipment to the analysis of the data.


Medical bone adhesives have been used in the field of bone repair because of the convenient operation,ensuring the integrity of the adhesive parts,and avoiding the stress shielding effect caused by mechanical fixation.The review briefly describes the performances of several bone adhesives which have wide applications,particularly introduces their bonding behaviors.Besides,it prospects the future of the medical bone adhesives.


In practice, the thesis introduced the function, implementation method and key technology of no paper testing system, which is based on windows NT local area network and used in windows95 environment.


The disabled working population is agemg creating a need for transitional programs in supported employment. Limited research in this area makes it difficult to design programs which adequately address their needs which affects the quality of service provision. A review of Scopus, CINAHL, MEDLINE; Psyclnfo and ISI Web of Science databases was conducted. Outcomes of interest were studies looking specifically at perceptions of disabled workers in supported employment making the transition to retirement. Due to the dearth of information on this topic studies focusing on non-disabled populations or disabilities though injury or illness were included. Major findings suggest when workers perceive their input into retirement transitions as limited it can affect their health and well-being in retirement. Understanding the disabled workers' perceived change form worker role to retiree will assist in establishing more effective bridging programs during this transitional stage. Occupational therapists can play an impmiant role in enabling the disabled workforce to age in place and enjoy active and fulfilling lives during their retiree years. Naomi Goods Supervisor: Associate Professor Jeannine Millsteed Co-Supervisor: Dr. Sonya Girdler August 2009 Retirement Transitions 3


The study adopts van Leeuwen's social semiotics theory. The study reveals that the advertisers deploy semiotic resources which suit the symbolic context of appealing to the dreams and anxiety of the admission seekers. It also demonstrates how general features of advertising language are harnessed creatively with digital resources to achieve rhetorical effect.


Nearly fi ft y years ago, on October 7, 1969, the German Democratic Republic (GDR) celebrated it twentieth anniversary. Art exhibitions in every "Bezirkshauptstadt" (district capital), political demonstrations, concerts, and festivals in the capital of Berlin were intended to generate an optimistic atmosphere. While the state Socialist Unity Party (SED) looked back at twenty years of existence, the perspective into the future was described in the brightest colors: "The GDR — that is the modern, Socialist German state that owns the future."2 Tirelessly, the leadership of the SED under Walter Ulbricht promoted the idea that the transformation of the Socialist system towards Communism would be achieved under its rule. In this deterministic conception, science played a key role: With the help of science, the future could be forecasted accurately and with certainty.3 An important part of the larger frame of the festivities around the twentieth anniversary, now mostly forgotten, was the grand opening of a campus for computer training and education in Wuhlheide, in the eastern outskirts of Berlin. Here, in the middle of the woods, plans were made for the utopia of a highly developed, technologically advanced, and modern Socialism within an architectural and artistic environment.4


A copolymer of low molecular weight epoxy-terminated polydimethylsiloxane( E-PDMS) and toughing modified phenolic resin was synthesized by E-PDMS, phenol and formaldehyde. The structure,mechanical properties and thermal stability of the copolymer before and after modification were examined by FT-IR,electronic universal testing machine and TG-DTA thermal analyzer. The effects of four different relative molecular mass of E-PDMS on the mechanical properties of the modified phenolic resin were studied.The results showed that the impact strength and tensile strength of copolymer was better than those of PF. The temperature of E-PDMS( 950 g / mol) modified phenolic resin 20% weight loss,the peak temperature and residual coke yield at 800 ℃ of the modified resin were 448 ℃,572. 9 ℃,and 55. 6% respectively. Small molecular weight of E-PDMS was beneficial to modification of PF.


THINKING ABOUT MARKETS. In the Game. For What It's Worth. Taking Care of Business. Take My Risk, Please. The Beating Heart. The Shape of Things to Come. The Original Sin. TOWARD THE DYNAMIC OPTION SELECTION SYSTEM. But Not the Obligation. Choose Your Weapons. So Many Positions, So Little Time. Do the Right Thing. Index.


In Android, communications between apps and system services are supported by a transaction-based Inter-Process Communication (IPC) mechanism. Binder, as the cornerstone of this IPC mechanism, separates two communicating parties as client and server. As with any client-server model, the server should not make any assumption on the validity (sanity) of client-side transaction. To our surprise, we find this principle has frequently been overlooked in the implementation of Android system services. In this paper, we demonstrate the prevalence and severity of this vulnerability surface and try to answer why developers keep making this seemingly simple mistake. Specifically, we design and implement BinderCracker, an automatic testing framework that supports parameter-aware fuzzing and has identified more than 100 vulnerabilities in six major versions of Android, including the latest version Android 6.0, Marshmallow. Some of the vulnerabilities have severe security implications, causing privileged code execution or permanent Denial-of-Service (DoS). We analyzed the root causes of these vulnerabilities to find that most of them exist because system service developers only considered exploitations via public APIs. We thus highlight the deficiency of testing only on client-side public APIs and argue for the necessity of testing and protection on the Binder interface - the actual security boundary. Specifically, we discuss the effectiveness and practicality of potential countermeasures, such as precautionary testing and runtime diagnostic.


Jackson type direct theorems are considered in variable exponent Lebesgue spaces Lp(x) with exponent p(x) satisfying 1≤esinfx∈0,2π]p(x), esssup∈[0,2π]p(x)<∞, and the Dini–Lipschitz condition. Jackson type direct inequalities of trigonometric approximation are obtained for the modulus of smoothness based on one sided Steklov averages Zvf(⋅):=1v∫v0f(⋅+t)dt in these spaces. We give the main properties of the modulus of smoothness Ωr(f,v)p(⋅):=∥(I−Zv)rf∥p(⋅)(∈N)in Lp(x), where I is the identity operator. An equivalence of the modulus of smoothness and Peetre's K-functional is established.


This Masters Research Project (MRP) explores the elements and benefits of the Co-Creation design approach and focuses on engagement of non-designers by designers during the physical space design process. The project's objective, beyond research, is to enhance the design process of physical space with a co-creative approach to participation by non-designers, mainly clients and end users. To that end, the researcher adapted and tested several of the most successful Co-Creation tools and methods from other design fields for optimal inclusion of non-designers by designers. Based on an extensive literature review and expert interviews, the researcher designed and conducted a co-creative workshop for professional designers. Data was gathered on the designers' understanding of and feelings about the design process, and on their experience with the co-creative techniques utilized.
Data analysis and synthesis led to many anticipated outcomes and to unexpected concerns centered on the value and trust of, and empathy with, the designer during a co-creative process with non-designers. This MRP offers the physical space design field data about and guidelines for productive, iterative Co-Creation of the design process. Perhaps a great value is in identifying the dearth of information regarding the designers' needs during Co-Creation. "Recommendations & Next Steps" poses a series of new questions for researchers interested in studying the designers' perspective further.
The MRP moves into solution-finding for professionals via the appended Guide to Effective Co-Creation of Physical Spaces, a step-by-step, stand-alone users' guide for designers to facilitate productive co-creation of physical space design projects.


We study the mechanism of instability in transition edge sensor (TES) bolometers used for ground based observations of the Cosmic Microwave Background (CMB) at 270GHz. The instability limits the range of useful operating resistances of the TES down to ≈50% of R_n, and due to variations in detector properties and optical loading within a column of multiplexed detectors, limits the effective on sky yield. Using measurements of the electrical impedance of the detectors, we show the instability is due to the increased bolometer leg G for higher-frequency detection inducing decoupling of the palladium-gold heat capacity from the thermistor. We demonstrate experimentally that the limiting thermal resistance is due to the small cross sectional area of the silicon nitride bolometer island, and so is easily fixed by layering palladium-gold over an oxide protected TES. The resulting detectors can be biased down to a resistance ≈10% of R_n.


The invention discloses a nano-composite anti-ultraviolet organic coating finishing agent and a preparation method thereof. The organic coating finishing agent comprises 20.0-30.0 parts of a polyether methylsiloxane-co-benzophenone derivative methylsiloxane-co-dimethyl siloxane copolymer, 5.0-15.0 parts of hydroxyl polyether terminated polyethylene terephthalate, 4.5-10.0 parts of water dispersible phenyl modified silicon/titanium sol, 2.0-3.0 parts of a water-soluble silane coupling agent, 10.0-20.0 parts of a waterborne polyurethane binder, 0.3-0.5 parts of a dispersing agent, 0.5-3.0 parts of a thickening agent, 0.1-0.5 parts of an antifoaming agent, 0.1-0.3 parts of an organic tin emulsion catalyst and 12.0-31.0 parts of H2O. The prepared nano-composite anti-ultraviolet organic coating finishing agent is applied to surfaces of polyester and the like through blade coating, then drying and setting are performed, and cloth samples can have a good anti-ultraviolet effect and touch smooth and elastic.


UNDER natural conditions, nearly all major forest types of the Northern Rocky Mountain region are dependent on fire for their existence. Ponderosa pine, white pine, lodgepole pine, larch, and Douglas-fir are all seral types, largely perpetuated by wildfire. The role played by fire in regeneration of these forests is principally that of opening up the forest and creating a mineral soil seedbed. Where these forests are protected from wildfire, but are opened up by timber harvesting, controlled fire is a convenient way of obtaining a mineral soil seedbed. Another reason for controlled burning is to reduce the wildfire hazard created by logging residue. One of the most efficient methods for harvesting mature or over-


Drug toxicity can be evaluated during the prehospital period by an algorithm that classifies simple mechanisms of toxicity of vari-ous drugs with the cholinergic and adrenergic systems. The study involved three hundred patients who had been poi- soned by neurotransmitter acting drugs. Data were gathered on clinical condition, hemodynamics (cardiac output [CO], blood pressure [BP], peripheral resistance [TPR]), and ECG picture. Patients were categorized as either one of two groups. The first group had tachycardia, constricted pupils, and dry skin (chronopositive group). The second group had bradycardia, con- stricted pupils, and moist skin ( chrononegative group). The first group presented with: 1) an anticholinergic syn- drome (caused by atropine sulfate, HI blockers, N-central block-ers), that included delirium, increased cardiac sounds, sinus tachycardia, slightly increased CO and BP, and almost normal TPR; 2) an adrenergic syndrome (amphetamines, theophylline, ephedrine, L-dopa, etc) with psychosis, flapping first heart sound, systolic murmur, high CO, high BP, and low peripheral resistance (and increased frequency of arrhythmias); or 3) an alpha blockade syndrome (phenothiazines, TCA, etc.) with a delirium-soporific condition, split heart sounds, frequent His bundle blockade, low CO and BP, and low TPR. The second group was represented by: 1) cholinergic syn- drome (opiates, cardiac glycosides, reserpine, etc.) with weakness of the first cardiac tone, bradycardia, low CO, BP, PTR; 2) alpha- 2-adrenergic syndrome (clonidine, verapamil, alpha-metha-dopa), with diminished heart sounds, low CO, BP and PTR, more expressive than the previous group, or 3) Experimental studies in 50 dogs with different models of acute pancreatitis revealed strict dependency between the rapidity of peritoneal exudation, average time of hemorrhagic necrotic foci formation, and mortality (Spierman correlation ranks + 0.855 0.924). The study concluded that the severity of acute peri- tonitis (AP) influences the incidence of necrotic foci formation and can be quantitatively evaluated by means of coefficient of peritoneal exudation (CPE). small, and permitted modeling of the data. The model for the median frequency estimated VF ischemia times to within +1.3 minutes.To demonstrate the feasibility of this technology in humans the VF signal was recorded in humans who had a cardiac arrest during Holter monitoring. The FFT analysis of these signals demonstrated that although there are quantitative differences in the ECG signal during VF compared with swine, there are quali-tative similarities. Specific frequency parameters demonstrate a dynamic and repeatable pattern with respect to time during VF in humans. A for predicting 1990;20:787-791.] Several recent studies have defined die minimal myocardial and cerebral blood flow requirements during ventricular fibrillation cardiac arrest. These studies demonstrate that the minimal myocardial blood flow required to meet the metabolic demands of the fibrillating myocardium is approximately 50 ml/min/lOOg (one-third of the coronary flow required during normal sinus rhythm flow). The cerebral blood flow requirements approxi- mate 10 ml/min/lOOg (20-25% of normal sinus rhythm flow) during cardiac arrest. In animal models of out-of-hospital cardiac arrest in which the ischemia time prior to cardiopulmonary resuscitation (CPR) is 10 minutes, myocardial and cerebral blood flow, as measured with radio-labelled microspheres, is less than 5 ml/min/lOOg to the myocardium, and less that 3 ml/min/lOOg to the cerebral cortex. These studies demonstrate (0.02 mg/Kg) of epinephrine in out-of-hospital cardiac arrest, a multi-center, clinical trial was conducted. This study will examine the effectiveness of these epinephrine regimens on hospital discharge rates and neurolog- ic outcome in refractory ventricular fibrillation, asystole, and electrical-mechanical dissociation. car-diotocographic monitoring is recommended for appropriate patient care. The burn literature on pregnant patients suggest that complications correlate with the extent of body surface burned. Avoidance of maternal hypoxia, shock, and sepsis is critical because all are associated with increased fetal mortality. To reverse sinus rhythm in paroxysmal supraventricular tachycar- dia (PST), mobile cardiac care units (MCCU) have used intravenous (IV) administration of verapamil or adenosine-triphos- phate (ATP). A one-year experience was analyzed to compare the effectiveness and safety of these two drugs. Verapamil (5-25mg IV) was administered in 63 cases of PST (60 patients); ATP (10-40mg rV) was administered in 49 cases (45 patients). The dif- ference between these two groups in age, sex, previous history of PST, duration of paroxysm, and pre-treatment of heart rate, blood pressure was not significant (NS, p>.05). Verapamil termi-nated PST in 58 (92.1%) cases, or in 55 (91.7%) patients; ATP was effective in 44 (89.8%) cases, or in 40 (88.9%) patients (NS). Hemodynamically significant heart blocks took place in two cases (3.2%) after verapamil, and in one case (2.0%) after ATP administration (NS). No other complications were registered. Three cases of PST recidivism within the first 30 minutes after sinus rhythm reversion occurred in the ATP group, in patients who got verapamil not a single case of re-paroxysm was described (p<.05), It is concluded that IV ATP in PST is neither more dangerous nor less effective than verapamil, which traditionally is used in prehospital conditions. Analysis of thermometric curve of the total volume of expired air one to obtain the following indices: Maximal temperature of expiratory gas (T-Max); Mean quantity of expiratory gas temperature (T-Mean); Quantity of heat in the unit of time (QT). Results: The quantity T-Max corresponds to the temperature of pulmonary arterial blood, which in turn is prognostic for the outcome of traumatic shock. The quantities T-Mean and QT correspond to functional lung area, these indices may serve as criteria for severity of lung injury. The combination of thermometric indices cor- relates inversely with the magnitude of cardiac output. Conclu-sion: TEA may be useful in clinical monitoring in trauma shock patients. Experience of 245 extracorporeal pig spleen joining (EPSJ) to patients with pyo-septic and tumor diseases established that this procedure has a high treatment effectiveness. In order to define the possible EPSJ mechanisms, the influence on blood ex vivo and in vivo was investigated. It has been demonstrated that the level of middle molecular mass substance (MMS), free hemoglobin concentration (FHb), and osmolarity essentially were increased in blood after its transfusion through the pig spleen. These changes provide evidence of the functions of pig spleens. Simultaneously, EPSJ decreased the number of circulating im- mune complexes (CIC), granulocyte, and thrombocyte quantity, and myoglobin level. Filtration pressure was decreased. This demonstrated the adsorption level of EPSJ. The resorption effect of EPSJ consisted of a decreased of MMS, FHb, fibrinogen, CIC, and urea levels. Fractional composi-tion of blood proteins was normalized and the concentration of superoxide substances was decreased. There also was an influence of EPSJ on the immune system: one hour after the proce- dure was finished, granulocyte and thrombolcyte quantity was restored and the new leucocyte pool was distinguished from the initial one by a normal level of chemotactic and bactericidal activity. In 18-20 hours, there occurred an increase of T-active and T-1,5 lymphocytes and decrease of T-zero lymphocytes. Thus, the effect of EPSJ is multifactorial and connected with toxic metabolites elimination, with CIC and corpuscular particles adsorption simultaneously with stimulation of the immune system. Reinfarction complicates approximately 10% of the cases of acute myocardial infarction (AMI) and significandy worsens its prognosis. Systemic thrombolytic therapy (STT) is known to increase the risk of reinfarction. Intravenous (IV) laser radiation of the circulating blood has been reported to improve myo- cardial metabolism, decrease the incidence of arrhythmias, and to possess a moderate hypocoagulation effect in AMI. In the pre- sent study, the effect of IV laser radiation (V=632.8nm, total dose=1.0 J/kg/course of treatment) on the risk of reinfarction, has been studied in 102 patients with AMI. Three identical groups of patients were determined based on age, sex, and site and size of the infarction: 1) 35 patients with AMI and STT (streptodebase, APSAC, and streptokinase); 2) 34 patients with AMI, STT, IV laser radiation; and 3) 33 patients with AMI, but without both STT and IV laser radiation. Retrospective analysis of clinical, ECG, and laboratory data showed that 2-3 weeks after SMI reinfarction developed: in the first group in the patients treated with APSAC,—in 24.5±5.7%; in tion, panels as: MI pretreatment of the animals purified antidigoxin antibody in a five-fold reduction of the incidence of ventricular arrhythmias. However, in these experi- ments, acute coronary ligation alone did not cause the changes in the activity of myocardial Na,K-ATPase and Na/K-pump. At the same time, pretreatment of coronary ligated animals with 1 mg/Kg propranolol led to occurrence of effects resembling some of the symptoms of acute digitalis overdose, significant inhibition of myocardial Na,K/pump, and pronounced increase of plasma potassium concentration. Administration of antidigoxin antibody to propranolol-pretreated rats exposed to coronary ligation in parallel to anti-arrhythmic effect prevented both inhibition of myocardial Na/K pump and development of hyper- kalemia. These results provide further evidence that elevated plasma concentrations of EDLF contribute to genesis of the early ventricular arrhythmia in MI. The fact that acute blockade of adrenoceptors unmasked the effects of EDLF points out the importance of


This article has the general objective to verify the accessibility of academics with a disability or reduced mobility in a teaching center of a Federal Public University of Santa Catarina. To meet this goal, there are this specific objectives: Check for people with disabilities or reduced mobility; Verify the sustainability of accessibility with a disabled and propose a summary management plan - 5W2H for the deficit issues. The 5W2H is an objective management tool and consists of seven questions to answer to the deficit issues. It is noteworthy that can be used for decision making about issues found after the calculation of sustainability. The methodology of the aims is considered descriptive and exploratory. With regard to the technical procedures this is a case study. The approach to the problem is characterized as qualitative. In the end it was concluded that the overall sustainability of the accessibility obtained the 48.8% rate, considered "regular", "only serves legislation". Thus, it is understood that people according to the law in Brazil have the right to study and all institutions need to provide access and use of environments for people with disabilities or reduced mobility. As a process of continuous improvement the 5W2H suggests as one of the actions: increasing the number of restrooms for accessibility within what the law provides. The study covers analysis of the ten dimensions for evaluation of courses by INEP.


Abstract Nickel crystal chemistry was systematically studied in various phyllosilicates, mainly the natural phases selected from the 'garnierites' of the supergene ore deposits of New Caledonia. Minerals which do not usually occur in New Caledonian parageneses were synthesised, as they could represent intermediate phases of genetic importance. In the kerolite-pimelite series, a linear relationship occurred between the ratio I (13,20)/I (02,11) of the hk bands and Ni-content. Diffuse reflectance spectra were used to derive the crystal chemical parameters of Ni. These confirmed its divalent character and its occupation of octahedral sites; the resulting structural distortion was slight and could not be detected in some minerals. There was no optical evidence for Ni atoms in 4-fold coordination. The two main parameters which showed significant variations among the studied phases were site distortion and crystal field stabilization energy (CFSE). Site distortion was at a maximum in trioctahedral smectites and sepiolite. CFSE depended on the mineralogy, crystallinity and chemical composition (Al-content) of the phase. Finally, clay minerals are classified according to the increasing stability of Ni in the octahedral sheet, which has been tentatively related to the geochemical distribution of this element. Secondary minerals are usually enriched vs. primary ones and among them are nepouite and kerolite which exhibit a high CFSE in contrast to sepiolite.


The purpose of this study was to compare the effectiveness of CPAP therapy and traditional therapy on hypernasality in dysarthric speakers. The 18 subjects were dysarthric speakers with hypernasality. CPAP therapy and traditional therapy group were divided into 18 subjects, each group was randomly a...


In this paper we consider the properties of group divisible designs and triangular designs which belong to linked block designs. These designs have minimum number of experiments among the same average efficiency factor Optimal complete diallel cross designs are constructed by these designs. A list is prepared of all linked block designs in the class of group divisible designs and triangular designs enumerated by Clatworthy(1773).


Global economy was significantly affected by the global financial crisis and especially the budget balance of all countries. Sovereign debts cause the lack of stability and the shift of monetary policy. This paper is about the recent evolutions in euro zone and its perspectives. The Euro break –up scenario should give unexpected consequences. Under the current structure and with the current membership, the Euro does not work. Either the current structure will have to change, or the current membership will have to change. On the other hand, the Euro break –up means economic and political costs which are not agree at the moment. The cost of a weak country leaving the Euro is significant. Consequences include sovereign default, corporate default, collapse of the banking system and collapse of international trade. The risk case, of break-up, is considerably more costly and close to zero probability. Countries cannot be expelled, but sovereign states could choose to secede. So, the perspectives of Euro Zone are fiscal confederation and fiscal discipline, not break-up.


Division and growth of chloroplasts was studied during leaf development of Xanthium pensylvanicum at various stages of development represented by the leaf plastochron index.Between leaf plastochron indices -1.00 and 2.56 chloroplast division was observed with little enlargement. Between 2.50 and 5.00 chloroplasts enlarged in diameter with an average rate of 0.21 µm per day. At leaf plastochron index 5.00 chloroplasts attained their mature size of 6.12 µm. No chloroplast division was found after leaf plastochron index 2.50. A change in shape of plastids from spherical proplastids to discoidal accompanied their growth during stages 2.50 and 5.00.


This project investigates the development of automated tools for video monitoring using multiple cameras in support of security applications. The project has both experimental and theoretical components. In Year 4, we designed two novel methods to improve the performance of wide area video surveillance applications by using scene features. First, we evaluated the drift in intrinsic and extrinsic parameters for typical pan-tilt-zoom (PTZ) cameras, which stems from accumulated mechanical and random errors after many hours of operation. When the PTZ camera is out of calibration, we show how the pose and internal parameters can be dynamically corrected by matching the scene features in the current image with a pre-computed feature library. Experimental results show that the proposed method can keep a PTZ camera calibrated, even over long surveillance sequences. Second, we introduced a classifier to identify scene feature points, which can be used to improve robustness in tracking foreground objects and detect jitter in surveillance videos sequences. We show that the classifier produces improved performance on the problem of detecting counterflow in real surveillance video. We have also developed new approaches for anomaly detection based on characterization of anomalies using local spatio-temporal signatures that occur over a small window of time or space.


Sometimes vibro-acoustic engineers encounter puzzling and, at first glance, paradoxical problems. A paradox used to be defined as a result or statement that sounds contradictory or absurd but may in fact be true. In science, most paradoxes come from the inability to interpret the differences between the observed and theoretically (or intuitively) expected data. Such anomalies can be solved with a new theory or breakthrough experiment, which may not be easy but moves people forward in theory and practice (the genius, paradox's friend). Fortunately, apparent anomalies in vibroacoustics have been sooner or later resolved. Let's describe some apparent paradoxes in airborne sound transmission. Abnormally low sound insulation of multiple partitions with no sound absorption in air gaps. By analogy to thermal insulation, some engineers believe that good sound insulation afforded by double or triple partitions is enhanced mainly by the number of air gaps. Such a mistake may result in misleading conclusions – the more air gaps, the higher the direct sound transmission loss of a partition. However even at high frequencies (where the mass-spring-mass resonances can be neglected), this opinion proved wrong for the ideal partition consisting of N similar infinite panels separated by equal air gaps:


An output distribution system extracts user-specific information from job data that is generated in response to an output request, obtains terminal-specific information that identifies a terminal that is associated with a user specified by user-specific information, and transmits drawing data of the job data to an output destination determined based on the identified terminal.


SUMMARY
Pollen analysis has been carried out on surface moss polsters from oak woodland and moorland communities in West Yorkshire, and the results have been compared with the composition of the surrounding vegetation. In general, the pollen specta reflected the adjacent plant communities well, but certain marked anomalies have been observed. The deposition of Alnus and Corylus pollen in particular appeared to be erratic, and certain of the non-arboreal pollen types such as Rumex, the Rubiaceae and the spores, had a markedly peaked distribution. Vaccinium, an important member of the woodland and moorland plant communities, was scarcely represented in the surface samples.

The distribution of arboreal pollen at increasing distances from the woodland edge has been examined by analysing polsters collected along three transect lines. A very rapid decline in arboreal pollen within 100 m of the woodland edge was observed in each case.

The application of these results to the ecological interpretation of pollen diagrams is considered.


It is shown that every a-additive a-finite invariant measure on an abelian group has a proper a-additive invariant extension. We consider a-finite countably additive measures which vanish on points and are nonidentically zero. Throughout this paper the word "measure" will mean a measure enjoying all the above properties. A measure m defined on a a-algebra S of subsets of X is called invariant with respect to a group G of bijections of X if for any T E G and A E S the image T*(A) is an element of S and m(T*(A)) = m(A). A measure m defined on a cr-algebra of subsets of a group G is called invariant if it is invariant with respect to left translations. Sierpin'ski (quoted in Szpilrajn [7]) asked whether there exists in Euclidean ndimensional space En a maximal extension of the Lebesgue measure invariant with respect to the group of isometries of El. Hulanicki [2] proved that if (XI is less than the first real-valued measurable cardinal, IGI < IXI, and m is a measure on X invariant with respect to G and vanishing on sets of cardinality < IXj, then there exists a proper extension of m invariant with respect to G. Thus he solved Sierpinski's problem under additional set theoretic assumptions. Harazigvili [1] gave a negative answer to this question for n = 1 without any extra hypotheses. He also proved that there is no maximal measure invariant with respect to translations on any Euclidean space. In other words the group of translations of En does not carry maximal invariant measures. Our theorem is a generalisation of the above result. THEOREM. Every invariant measure on an abelian group (G, +) has a proper invariant extension. PROOF. We start with the following lemma, essentially due to Szpilrajn [7]. The easy proof is left to the reader. LEMMA. Let m be an invariant measure on G. If there exists a set E c G such that: 1. E is not a set of m measure zero. 2. For every sequence {gn: n E w} of elements of G, there exists a sequence {ho: a < w, } of elements of G such that for distinct a, /, m ([hc+ U (gn+ E) n h + U (gn + E)j) 0 t mnm w ar etnswon then the measure m has a proper invariant extensgion. Received by the editors November 1, 1982. 1980 Mathematics Subect Clasifsfiion. Primary 28C10, 43A05. Keu words and vhrases. Invariant measure. abelian group. (@)1984 American Mathematical Society 0002-9939/84 $1.00 + $.25 per page


Based on the technical statistics and comparative analysis by watching the recorded performances of the Chinese Men's volleyball team and the other seven teams in Men's Qualification Tournament for the 2004 Athens Olympic Games, the paper finds out the superiority and deficiency of the Chinese men's volleyball team leading to its success and failure. Accordingly the paper puts forward some corresponding suggestions and solutions to future training and improvement of the Chinese men's volleyball team.


The streak tube imaging lidar (STIL) system is a new 3D imaging technology that can obtain a complete frame image of the target with only one laser pulse and it has many advantages such as high frame rate, big field of view and so on over the scanning-mechanism system. The principle of the experiment will be introduced firstly and the pre-process of the data will be simply discussed, such as correction of image distortion, the noise filter and image enhancement, data segmentation and so on. All the methods to the above data pre-process are specially adopted for the STIL system. The range of the target, the time of the photoelectron flight and the range of the target image on the phosphor screen have a linear relationship and it will be proved; according this, a mathematical model to reconstruct the 3D image is put forward and the algorithm to calculate the relative range of the target is confirmed. Based on the model and the algorithm, a program in the VC++ and matlab environment to analyze the lidar data, reconstruct and display the 3D image of the target is compiled. The result verifies the model and the algorithm effective.


The influence of the synthesis parameters on the mean characteristics of single-wall carbon nanotubes in soot produced by the laser vaporization of graphite has been analyzed using optical absorption spectroscopy. The abundance and mean diameter of the nanotubes were found to be most influenced by the furnace temperature and the cobalt/nickel catalyst mixing ratio. Via an analysis of the fine structure in the optical spectra, the existence of preferred nanotube diameters has been established and their related fractional abundance could be determined. The results are consistent with nanotubes located mainly around the armchair axis.


Multi-Inputs-Multi-Outputs (MIMO) systems are recognized mainly in industrial applications with both input and state couplings, and uncertainties. The essential principle to deal with such difficulties is to eliminate the input couplings, then estimate the remaining issues in real-time, followed by an elimination process from the input channels. These difficulties are resolved in this research paper, where a decentralized control scheme is suggested using an Improved Active Disturbance Rejection Control (IADRC) configuration. A theoretical analysis using a state-space eigenvalue test followed by numerical simulations on a general uncertain nonlinear highly coupled MIMO system validated the effectiveness of the proposed control scheme in controlling such MIMO systems. Time-domain comparisons with the Conventional Active Disturbance Rejection Control (CADRC)-based decentralizing control scheme are also included.


Background: Two large clinical trials have shown the benefit of aromatase inhibitors in healthy women to reduce the risk of developing breast cancer (MAP.3 and IBIS-II). Here, we report blinded 10-year median follow-up efficacy data for the IBIS-II trial, which compared anastrozole to placebo in women at increased risk of developing breast cancer. Material and Methods: 3864 postmenopausal women at increased risk of developing breast cancer were recruited into a double-blind trial of anastrozole (N=1920) versus matching placebo (N=1944) for 5 years. The primary objective of this study was to determine the efficacy of anastrozole in preventing breast cancer (both invasive and ductal carcinoma in situ (DCIS)), overall and particularly for the post 5-year time period. Secondary endpoints included prevention of oestrogen receptor positive breast cancer, breast cancer mortality, non-breast cancer deaths, other cancers, cardiovascular disease, fractures, and musculoskeletal events. Results: After a median follow-up of 10.9 years (IQR 8.8-13.0), a total of 241 breast cancers have been reported (HR=0.50 (0.38-0.65), P Conclusion: This updated analysis of the IBIS-II trial confirms the significant reduction in breast cancer occurrence with anastrozole in the post-treatment follow-up period. These results indicate a long-term preventive benefit with anastrozole for ER-positive breast cancer in postmenopausal women. Citation Format: Jack Cuzick, Ivana Sestak, John Forbes, Mitchell Dowsett, Simon Cawthorn, Robert Mansell, Sibylle Loibl, Bernardo Bonanni, Anthony Howell, IBIS-II investigators. Ten year results of the international breast cancer intervention study II [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr GS4-04.


The complexity necessary for robotics software systems to dynamically respond to or handle a variety of evolving scenarios translates into serious development costs and engineering challenges. Dynamic variability is one new strategy for supporting the dynamic behavior of robotics control systems.


Abstract Background As part of its End TB strategy, the WHO has identified the need for non-sputum-based diagnostics that meet target product profiles (TPP) of 90% sensitivity and 70% specificity for diagnosis of Active TB (ATB) and 75% sensitivity and specificity for predicting progression from Latent TB (LTB) to ATB. The successful translation of a 3-gene blood-based signature, identified using diverse datasets, into a prototype point-of-care diagnostic, that meets the WHO TPPs, has demonstrated the power of integrating large amounts of heterogeneous data to identify generalizable disease signatures. We hypothesized that integration of more diverse datasets, comprising patients with ATB or other inflammatory lung diseases, would identify novel, robust signatures, for diagnosing ATB and predicting progression from LTB to ATB, that meet the WHO TPPs. Methods Using multi-cohort analyses, we integrated and analyzed data from 3,615 peripheral blood samples, in 49 publicly available transcriptomic datasets (discovery cohorts), from healthy controls and patients with LTB, ATB, and other diseases (COPD, viral infections, sarcoidosis, etc.). We used data from (1) 3,836 blood samples in 28 retrospective datasets and (2) 360 prospectively collected blood samples, from a household contact study in Moldova, as validation cohorts. Results Using the discovery cohorts we identified a 9-gene signature for diagnosing ATB patients from healthy controls, or individuals with LTB or other diseases. The signature achieved 90% sensitivity and 82% specificity in retrospective validation (Figure 1A) and 90% sensitivity and 69% specificity in the prospective cohort from Moldova (Figure 1B). In a longitudinal cohort of adolescents, the 9-gene signature predicted progression from LTB to ATB up to 1 year prior to sputum conversion with 76% sensitivity and 83% specificity (Figure 1C). Finally, the signature predicted prolonged lung inflammation post-treatment in the Catalysis Treatment Response Cohort (Figure 1D). 9-gene TB signature validates in independent retrospective and prospective cohorts. (A) ROC curves for comparing ATB vs. all other samples (All), or individually comparing ATB vs. Healthy, LTBI or Other Disease (OD) samples in independent retrospective validation and (B) a prospective Moldova cohort. (C) ROC curves comparing progressor and non-progressor samples collected at different time points in the Adolescent Cohort Study (ACS), for the 9-gene signature in solid lines and a previous 3-gene signature in dashed lines, (D) Distribution of the 9-gene score at different time points post-treatment in the Catalysis Treatment Response Cohort Study, for individuals with persistent lung inflammation at 24 weeks compared with those who had clear lungs at 24 weeks. Conclusion Overall, the 9-gene signature meets the WHO TPPs required for the End TB strategy. Disclosures Purvesh Khatri, PhD, Cepheid, Inc.: Advisor/Consultant|Inflammatix, Inc.: Advisor/Consultant|Inflammatix, Inc.: Inflammatix is in negotiations to license the 9-gene signature discussed here.|Inflammatix, Inc.: Stocks/Bonds.


Dams are important structures having many functions such as water supply, flood control, hydroelectric power and recreation. Although dam break failures are very rare events, dams can fail with little warning and the damage at the downstream of the dam due to the flood wave can be catastrophic. During a dam failure, immense volume of water is mobilized at very high speed in a very short time. The momentum of the flood wave can turn to a very destructive impact force in residential areas. Therefore, from risk point of view, understanding the consequences of a possible dam failure is critically important. This study deals with the methodology utilized for predicting the flood wave occurring after the dam break and analyses the propagation of the flood wave downstream of the dam. The methodology used in this study includes creation of bathymetric, DEM and land use maps; routing of the flood wave along the valley using a 1D model; and two dimensional numerical modeling of the propagation and spreading of flood wave for various dam breaching scenarios in two different urban areas. Such a methodology is a vital tool for decision-making process since it takes into account the spatial heterogeneity of the basin parameters to predict flood wave propagation downstream of the dam. Proposed methodology is applied to two dams; Porsuk Dam located in Eskişehir and Alibey Dam located in Istanbul, Turkey. Both dams are selected based on the fact that they have dense residential areas downstream and such a failure would be disastrous in both cases. Model simulations based on three different dam breaching scenarios showed that maximum flow depth can reach to 5 m at the border of the residential areas both in Eskişehir and in Istanbul with a maximum flow velocity of 5 m/s and flood waves having 0.3 m height reach to the boundary of the residential area within one to two hours. Flooded area in Eskişehir was estimated as 127 km, whereas in Istanbul this area was 8.4 km in total.


Quinacrine, the main antimalarial drug during World War II, has had a chequered history that included the successful repurposing as an intrapleural sclerosant for the treatment of malignant pleural effusions, a non-surgical method of female sterilisation, and the use as an immunomodulatory drug in lupus erythematosus. While no longer used for these former indications, quinacrine (re)emerged as an indispensable second-line drug for the treatment of nitroimidazole-refractory Giardia duodenalis infections, and thus depicts an indispensable "orphan drug".


Abstract The mixed-type rotation model around the a- and the c-axes for the molecular rotation of the NO2 radicals in Sodium nitrite is discussed. There found an intermediate state during the a-axis rotation that can explain some experimental results. The mechanism of polarization reversal can be explained by this model, and the transition temperature is estimated as 341 K by using Ising model.


In this article I compare the uses of texts designated 'mystical' in two traditions: the academic study of religions and the heavy metal music genre of drone metal. Rather than attempting to define mysticism, I review the ways in which quotations of texts have been employed in academic studies on mysticism, noting that many scholarly works devoted to understanding and categorising previous mystical texts have later been designated mystical themselves. Then, taking as a case study a recent album by drone metal group Om, I examine the related ways of reusing religious texts, sounds, symbols and practices in drone metal music, culture and discourse. I compare and contrast the uses of such texts, sounds, symbols and themes in both traditions, and the implications of their differing epistemological and cultural status. Setting up and then undermining a division between two kinds of textual reference in citation and recitation, I suggest that 'mysticism' in drone metal and in mystical scholarship is constituted through both uses. In a final example, I show how a webpage of listener comments attached to an online clip of Om's music displays a range of these 'mystical' textual practices.


Shadows in very high-resolution multispectral remote sensing images hinder many applications, such as change detection, target recognition, and image classification. Though a wide variety of significant research has explored shadow detection, shadow pixels are still more or less omitted and are wrongly confused with vegetation pixels in some cases. In this study, to further manage the problems of shadow omission and vegetation misclassification, a mixed property-based shadow index is developed for detecting shadows in very high-resolution multispectral remote sensing images based on the difference of the hue component and the intensity component between shadows and nonshadows, and the difference of the reflectivity of the red band and the near infrared band between shadows and vegetation cover in nonshadows. Then, the final shadow mask is achieved, with an optimal threshold automatically obtained from the index image histogram. To validate the effectiveness of our approach for shadow detection, three test images are selected from the multispectral WorldView-3 images of Rio de Janeiro, Brazil, and are tested with our method. When compared with other investigated standard shadow detection methods, the resulting images produced by our method deliver a higher average overall accuracy (95.02%) and a better visual sense. The highly accurate data show the efficacy and stability of the proposed approach in appropriately detecting shadows and correctly classifying shadow pixels against the vegetation pixels for very high-resolution multispectral remote sensing images.


KEY POINTS
A 52-year-old man in a long-term, same-gender sexual relationship presented with agitation, confusion and problems speaking for about two weeks. On assessment, his vital signs were normal, but he was agitated and had global aphasia. No other focal deficits were identified on a screening